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Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues
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Druggability Comparison: SMAD2 vs SMAD3

Direct Druggability Evidence

SMAD2

No ChEMBL druggability data found for SMAD2, indicating a lack of validated small molecule inhibitors or modulators in the ChEMBL database.

SMAD3

SMAD3 has documented bioactivity evidence with 25 compounds showing IC50 values ranging from 38.00 nM to 9894.00 nM, with the most potent compounds being CHEMBL601757 (IC50=38.00 nM, pChEMBL=7.42) and CHEMBL1334062 (IC50=39.00 nM, pChEMBL=7.41).Notable compounds include CHEMBL6246 (ELLAGIC ACID) with IC50=142.00 nM (pChEMBL=6.85). Key Finding: SMAD3 demonstrates significantly better druggability with validated small molecule inhibitors, while SMAD2 lacks such evidence. —

Structural Features Relevant to Druggability

### Cysteine Residues (Potential Covalent Drug Targets) SMAD2:Has 14 detected cysteines, with 2 ligandable cysteines (Q15796_C74, Q15796_C81), 3 binding-site cysteines, and 2 near binding-site cysteines. SMAD3:Has only 5 detected cysteines, with 0 ligandable cysteines, though 3 are binding-site cysteines. Implication: SMAD2’s ligandable cysteines (C74 and C81) represent potential sites for covalent inhibitor development, offering a druggability advantage over SMAD3 for this approach.

Protein Disorder and Binding Regions

SMAD2:Shows 22.7% disordered regions with 3 disordered regions (longest=68 residues) and 14.1% high MoRF propensity (longest segment=66 residues). SMAD3:Shows 22.6% disordered regions with 4 disordered regions (longest=67 residues) and 13.9% high MoRF propensity (longest segment=59 residues). Implication: Both proteins have similar disorder profiles, suggesting comparable challenges for traditional small molecule binding but potential opportunities for targeting protein-protein interactions through MoRF regions.

Druggable Pockets

SMAD2:FPocket scores range from 0.0 to 0.713 (avg=0.037), with the maximum suggesting at least one potentially druggable pocket. SMAD3:FPocket scores range from 0.0 to 0.136 (avg=0.010), indicating lower overall pocket druggability. —

Targeting Strategies

### 1. Direct Small Molecule Inhibition Current Status: - SMAD3: Validated approach with nanomolar inhibitors available - SMAD2: No validated small molecules reported Challenges: - Both proteins function as transcription factors, traditionally considered “undruggable” - High structural similarity between SMAD2 and SMAD3 may complicate selectivity ### 2. Protein-Protein Interaction (PPI) Disruption Both proteins form critical complexes: SMAD2 interactions:Forms heteromeric SMAD protein complexes and interacts with SMAD3, SMAD4, and numerous co-factors including CREBBP, EP300, SKI, SKIL. SMAD3 interactions:Interacts with SMAD2, SMAD4, and similar co-factors, with documented co-crystal structures with SMAD3, SMAD4, and ZFYVE9. Targeting opportunities: - SMAD2/3-SMAD4 heterotrimer formation - Interactions with transcriptional co-activators (CREBBP, EP300) - Interactions with inhibitory proteins (SKI, SKIL)

3. Covalent Inhibitor Development

SMAD2’s two ligandable cysteines (C74, C81) near binding sitesrepresent attractive targets for covalent inhibitors, potentially offering: - Improved selectivity over SMAD3 - Enhanced potency through irreversible binding - Longer duration of action

4. Targeting Post-Translational Modifications

Both proteins undergo extensive regulation: SMAD2:Participates in pathways including “SMAD2/3 Phosphorylation Motif Mutants in Cancer” and “Post-translational protein modification”. SMAD3:Shows biochemical activity with multiple kinases (CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1) and deubiquitinases (OTUB1, USP15, USP7). Targeting strategies: - Inhibit activating kinases (TGFBR1) - Inhibit CDKs that phosphorylate linker regions - Target E3 ubiquitin ligases (SMURF1, SMURF2, WWP2) - Inhibit deubiquitinases to promote degradation

5. Targeted Protein Degradation (PROTACs/Molecular Glues)

Advantages: - Circumvents need for traditional binding pockets - Can achieve selectivity through E3 ligase recruitment - Particularly attractive for SMAD2 given lack of direct inhibitors Feasibility:SMAD2 interacts with multiple E3 ligases including SMURF2, WWP2, ITCH, NEDD4, NEDD4L, andSMAD3 shows similar interactions with NEDD4, NEDD4L, SMURF1, SMURF2, WWP2, providing natural degradation pathways to exploit. —

Existing Therapeutic Approaches

### Indirect Targeting via TGF-β Pathway Both proteins are downstream of TGF-β receptor signaling: SMAD2:Participates in “TGF-beta receptor signaling activates SMADs” and “Signaling by TGF-beta Receptor Complex”. SMAD3:Similarly involved in TGF-β receptor signaling pathways. Clinical relevance: - TGF-β receptor inhibitors (e.g., galunisertib) indirectly block SMAD2/3 activation - This approach affects both proteins simultaneously, limiting selectivity —

Disease Context and Therapeutic Potential

### SMAD2 Disease AssociationsSMAD2 is associated with Loeys-Dietz syndrome 6, congenital heart defects, multiple types, 8, with or without heterotaxy, and numerous cancers including colorectal adenocarcinoma, glioblastoma, and breast cancer.

SMAD3 Disease Associations

SMAD3 is associated with Colorectal cancer and Loeys-Dietz syndrome 3, plusextensive associations with cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers. Therapeutic implications: - Cancer: Both are tumor suppressors; inhibition may be contraindicated - Fibrosis: SMAD3 inhibition shows promise (existing compounds available) - Cardiovascular disease: Context-dependent; may require selective modulation —

Genetic Constraint and Safety Considerations

### Loss-of-Function Tolerance SMAD2:Genetic constraint score for lof variants: 1.0 (mapped to LOEUF rank, lower = less tolerant). SMAD3:Genetic constraint score for lof variants: 0.9999799728393555. Interpretation: Both proteins show high constraint scores (~1.0), indicating that loss-of-function variants are relatively well-tolerated in the population, suggesting potential safety for therapeutic inhibition.

Essentiality

SMAD2 is not a core essential gene, andSMAD3 is not a core essential gene, indicating that complete inhibition may be tolerated, though context-dependent effects are likely. —

Tissue-Specific Expression Considerations

### SMAD2Shows high tissue-specific expression (z-score ≥2) in: segmented neutrophil of bone marrow (z=4), CD34-negative megakaryocyte cell (z=4), CD8-positive alpha-beta T cell (z=3), CD4-positive alpha-beta T cell (z=3), common lymphoid progenitor (z=3), conventional dendritic cell (z=4), CD4-positive alpha-beta thymocyte (z=5), CD8-positive alpha-beta thymocyte (z=4).

SMAD3

Shows high tissue-specific expression in: CD14-positive, CD16-negative classical monocyte (z=3), with generally lower tissue specificity than SMAD2. Implication: SMAD2’s higher expression in immune cells may complicate systemic inhibition due to immunological effects, while SMAD3’s broader expression pattern may present different toxicity concerns. —

Challenges and Considerations

### 1. Selectivity Between SMAD2 and SMAD3 - High structural similarity (both R-SMADs) - Overlapping functions in TGF-β signaling -Both form SMAD2/SMAD3:SMAD4 heterotrimers
  • Selective inhibition may require exploiting unique interaction surfaces or post-translational modification sites

2. Context-Dependent Functions

Tumor suppressor vs. oncogenic roles:

  • In early cancer stages: tumor suppressive (inhibition contraindicated)
  • In advanced cancer/metastasis: pro-metastatic (inhibition beneficial)
  • Requires careful patient stratification

3. Compensatory Mechanisms

SMAD2 shows phenotypic enhancement with SMAD3, andSMAD3 shows phenotypic enhancement with SMAD2, suggesting functional redundancy that may limit single-target efficacy.

4. Nuclear-Cytoplasmic Shuttling

SMAD2:Cytoplasmic and nuclear in the absence of TGF-beta; migrates to nucleus when complexed with SMAD4 or IPO7 upon TGF-beta stimulation; released from complex and exported by RANBP1 upon dephosphorylation by PPM1A. SMAD3:Shows similar cytoplasmic-nuclear shuttling; migrates to nucleus when complexed with SMAD4; released and exported by RANBP1 through PPM1A action. Implication: Targeting nuclear import/export machinery or phosphatases (PPM1A) could modulate both proteins’ activity. —

Summary and Recommendations

### Druggability Ranking: SMAD3 > SMAD2 SMAD3 advantages: 1. Validated small molecule inhibitors with nanomolar potency 2. Established screening assays and chemical starting points 3. Better characterized in fibrosis (clearer therapeutic indication) SMAD2 advantages: 1. Ligandable cysteines for covalent inhibitor development 2. Higher FPocket scores suggesting better pocket druggability 3. More tissue-restricted expression may reduce off-target effects ### Recommended Targeting Approaches (Priority Order) 1. SMAD3 direct inhibition (fibrosis, specific cancers) - Build on existing nanomolar inhibitors - Optimize for selectivity and pharmacokinetics 2. SMAD2 covalent inhibition (cardiovascular, specific cancers) - Target ligandable C74 or C81 - Develop selective covalent warheads 3. Dual SMAD2/3 PROTACs (advanced cancers, severe fibrosis) - Leverage endogenous E3 ligases (SMURF2, WWP2) - Achieve complete pathway blockade 4. PPI disruption (SMAD2/3-SMAD4 or co-factor interactions) - Target heterotrimer formation - Disrupt interactions with CREBBP/EP300 5. Upstream targeting (TGF-β receptors, activating kinases) - Indirect but clinically validated approach - Affects both SMAD2 and SMAD3 ### Key Unresolved Issues 1. Selectivity: Can SMAD2-selective or SMAD3-selective inhibitors be developed given structural similarity? 2. Context-dependence: How to stratify patients for tumor suppressor vs. pro-metastatic contexts? 3. Redundancy: Will single-target inhibition be sufficient or is dual targeting required? 4. Biomarkers: What pharmacodynamic markers can confirm target engagement in vivo? 5. Resistance: Will compensatory upregulation of parallel pathways limit efficacy? Possible speculation: Given the existing SMAD3 inhibitors and SMAD2’s ligandable cysteines, a rational drug development strategy might involve: 1. Near-term: Optimize existing SMAD3 inhibitors for fibrosis indications where the therapeutic rationale is clearest 2. Medium-term: Develop SMAD2-selective covalent inhibitors targeting C74/C81 for cardiovascular indications (Loeys-Dietz syndrome) 3. Long-term: Create bifunctional degraders (PROTACs) for dual SMAD2/3 targeting in advanced cancers where complete pathway blockade is desired The higher genetic constraint tolerance and non-essential status of both genes suggest that therapeutic inhibition may be feasible, though careful attention to tissue-specific and context-dependent effects will be critical for safety and efficacy.
    Gene Summary
    SMAD2 • Entrez:4087 • UniProt:Q15796
    Median span: null bp • Max span: null bp
    Functions (1)
    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma
    Diseases (2)
    Congenital heart defects, multiple types, 8, with or without heterotaxy Loeys-Dietz syndrome 6
    Pathways (36)
    SMAD2/3 Phosphorylation Motif Mutants in Cancer Developmental Biology Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Deubiquitination TGF-beta receptor signaling activates SMADs Signaling by TGFB family members Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex TGFBR1 KD Mutants in Cancer Post-translational protein modification FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Disease Generic Transcription Pathway Metabolism of proteins Gene expression (Transcription) Signal Transduction FOXO-mediated transcription Gastrulation RNA Polymerase II Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription FOXO-mediated transcription of cell cycle genes Loss of Function of SMAD2/3 in Cancer Transcriptional regulation of pluripotent stem cells SMAD4 MH2 Domain Mutants in Cancer Diseases of signal transduction by growth factor receptors and second messengers Formation of axial mesoderm Germ layer formation at gastrulation Downregulation of TGF-beta receptor signaling Formation of definitive endoderm Ub-specific processing proteases Loss of Function of SMAD4 in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Activin Signaling by TGF-beta Receptor Complex in Cancer Signaling by NODAL
    GO annotations (79)
    C:SMAD protein complex C:activin responsive factor complex C:chromatin C:cytoplasm C:cytosol C:heteromeric SMAD protein complex C:homomeric SMAD protein complex C:intracellular membrane-bounded organelle C:nucleoplasm C:nucleus C:protein-containing complex C:transcription regulator complex F:DNA-binding transcription activator activity, RNA polymerase II-specific F:DNA-binding transcription factor activity F:DNA-binding transcription factor activity, RNA polymerase II-specific F:DNA-binding transcription factor binding F:I-SMAD binding F:R-SMAD binding F:RNA polymerase II cis-regulatory region sequence-specific DNA binding F:RNA polymerase II-specific DNA-binding transcription factor binding F:SMAD binding F:chromatin binding F:cis-regulatory region sequence-specific DNA binding F:co-SMAD binding F:disordered domain specific binding F:double-stranded DNA binding F:identical protein binding F:metal ion binding F:phosphatase binding F:tau protein binding F:transforming growth factor beta receptor binding F:type I transforming growth factor beta receptor binding F:ubiquitin protein ligase binding P:DNA-templated transcription P:SMAD protein signal transduction P:activin receptor signaling pathway P:anatomical structure morphogenesis P:anterior/posterior pattern specification P:aortic valve morphogenesis P:cell differentiation P:cell fate commitment P:cell population proliferation P:determination of left/right asymmetry in lateral mesoderm P:embryonic cranial skeleton morphogenesis P:embryonic foregut morphogenesis P:endocardial cushion morphogenesis P:endoderm formation P:gastrulation P:in utero embryonic development P:insulin secretion P:intracellular signal transduction P:lung development P:mesoderm formation P:negative regulation of DNA-templated transcription P:negative regulation of cell differentiation P:negative regulation of ossification P:nodal signaling pathway P:odontoblast differentiation P:organ growth P:pancreas development P:paraxial mesoderm morphogenesis P:pericardium development P:positive regulation of BMP signaling pathway P:positive regulation of DNA-templated transcription P:positive regulation of epithelial to mesenchymal transition P:positive regulation of gene expression P:positive regulation of transcription by RNA polymerase II P:post-embryonic development P:primary miRNA processing P:pulmonary valve morphogenesis P:regulation of DNA-templated transcription P:regulation of transforming growth factor beta receptor signaling pathway P:response to cholesterol P:response to glucose P:secondary palate development P:transforming growth factor beta receptor signaling pathway P:trophoblast cell migration P:ureteric bud development P:zygotic specification of dorsal/ventral axis
    Predicted GO (71)
    regulation of production of miRNAs involved in gene silencing by miRNA transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of transcription from RNA polymerase II promoter in response to stress negative regulation of MAPK cascade negative regulation of protein phosphorylation negative regulation of protein modification process regulation of transcription from RNA polymerase II promoter in response to stress negative regulation of DNA binding transcription factor activity positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of phosphorylation regulation of kidney development regulation of epidermis development positive regulation of protein modification by small protein conjugation or removal I-kappaB kinase/NF-kappaB signaling regulation of transforming growth factor beta2 production nodal signaling pathway transforming growth factor beta receptor signaling pathway gene silencing by miRNA regulation of pathway-restricted SMAD protein phosphorylation negative regulation of activin receptor signaling pathway regulation of SMAD protein signal transduction negative regulation of pathway-restricted SMAD protein phosphorylation regulation of gene silencing by miRNA negative regulation of cellular response to growth factor stimulus regulation of epidermal cell differentiation proteasomal protein catabolic process regulation of production of small RNA involved in gene silencing by RNA cellular response to transforming growth factor beta stimulus positive regulation of protein catabolic process regulation of protein modification by small protein conjugation or removal positive regulation of MAPK cascade regulation of DNA-templated transcription in response to stress positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of fat cell differentiation pathway-restricted SMAD protein phosphorylation negative regulation of cell proliferation regulation of transforming growth factor beta receptor signaling pathway cellular response to BMP stimulus regulation of cellular response to transforming growth factor beta stimulus regulation of DNA binding transcription factor activity regulation of BMP signaling pathway negative regulation of intracellular signal transduction regulation of posttranscriptional gene silencing activation of MAPKK activity negative regulation of transcription by competitive promoter binding response to BMP regulation of protein ubiquitination histone modification regulation of gene silencing by RNA BMP signaling pathway stress-activated MAPK cascade positive regulation of SMAD protein signal transduction response to transforming growth factor beta regulation of vasculature development positive regulation of epidermal cell differentiation negative regulation of androgen receptor signaling pathway SMAD protein signal transduction negative regulation of myosin-light-chain-phosphatase activity positive regulation of DNA binding transcription factor activity regulation of angiogenesis regulation of cellular response to growth factor stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of keratinocyte differentiation activin receptor signaling pathway regulation of epithelial cell differentiation positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of stress-activated MAPK cascade negative regulation of BMP signaling pathway positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus SMAD protein complex assembly
    Predicted disease (1)
    aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709)
    MSigDB
    MSigDB H — Hallmark gene sets (broad biological states/processes) (1)
    HALLMARK_PI3K_AKT_MTOR_SIGNALING
    MSigDB C1 — Positional gene sets (cytogenetic bands) (1)
    chr18q21
    MSigDB C2 — Curated gene sets (pathways/literature) (103)
    SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP
    MSigDB C3 — Regulatory target sets (TF & miRNA targets) (121)
    MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P
    MSigDB C4 — Computational gene sets (co-expression/other) (14)
    GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A
    MSigDB C6 — Oncogenic signatures (1)
    SNF5_DN.V1_UP
    MSigDB C7 — Immunologic signatures (66)
    GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP
    Open Targets
    is_essential: false
    Disease annotations (810)
    Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm
    tissue_specific_expression
    frontal lobe-1
    endothelial cell of umbilical vein (resting)2
    zone of skin0
    regulatory T cell1
    pancreas-1
    suprapubic skin-1
    temporal lobe-1
    parathyroid gland-1
    spleen-1
    Brodmann (1909) area 9-1
    breast-1
    Brodmann (1909) area 24-1
    alternatively activated macrophage2
    segmented neutrophil of bone marrow4
    placenta-1
    mature eosinophil1
    granulocyte monocyte progenitor cell0
    gall bladder-1
    esophagus muscularis mucosa-1
    seminal vesicle-1
    endocervix-1
    lower leg skin-1
    megakaryocyte-erythroid progenitor cell0
    endothelial cell of umbilical vein (proliferating)2
    CD8-positive, alpha-beta T cell3
    cerebral cortex-1
    CD34-negative, CD41-positive, CD42-positive megakaryocyte cell4
    hippocampus proper-1
    uterus-1
    CD4-positive, alpha-beta T cell3
    tonsil-1
    esophagus0
    transverse colon-1
    pituitary gland-1
    coronary artery-1
    memory B cell0
    sigmoid colon-1
    cerebellum-1
    erythroblast2
    prefrontal cortex-1
    nucleus accumbens-1
    adipose tissue0
    effector memory CD8-positive, alpha-beta T cell1
    vermiform appendix-1
    greater omentum-1
    hematopoietic multipotent progenitor cell1
    leukocyte2
    adrenal gland-1
    atrium auricular region-1
    thyroid gland0
    tibial artery-1
    common lymphoid progenitor3
    urinary bladder-1
    duodenum-1
    heart muscle-1
    small intestine-1
    neutrophilic metamyelocyte3
    minor salivary gland-1
    rectum0
    ovary-1
    substantia nigra-1
    subcutaneous adipose tissue-1
    class switched memory B cell1
    fallopian tube-1
    esophagus mucosa-1
    CD38-negative naive B cell0
    bronchus-1
    EBV-transformed lymphocyte0
    small intestine Peyer's patch-1
    kidney-1
    hippocampus-1
    macrophage1
    aorta-1
    skeletal muscle tissue-1
    CD3-positive, CD4-positive, CD8-positive, double positive thymocyte4
    caudate-putamen-1
    liver-1
    cytotoxic CD56-dim natural killer cell2
    mature neutrophil2
    hypothalamus-1
    transformed skin fibroblast-1
    bone marrow-1
    inflammatory macrophage0
    cortex of kidney-1
    lung-1
    epididymis-1
    abdomen-1
    saliva-secreting gland-1
    nasopharynx-1
    colon0
    cerebellar hemisphere-1
    stomach-1
    testis-1
    smooth muscle tissue0
    putamen-1
    CD4-positive, alpha-beta thymocyte5
    C1 segment of cervical spinal cord0
    blood-1
    hematopoietic stem cell1
    caudate nucleus-1
    amygdala-1
    brain0
    central memory CD8-positive, alpha-beta T cell1
    effector memory CD4-positive, alpha-beta T cell1
    ectocervix-1
    prostate gland-1
    conventional dendritic cell4
    central memory CD4-positive, alpha-beta T cell1
    heart left ventricle-1
    CD14-positive, CD16-negative classical monocyte0
    vagina-1
    esophagogastric junction-1
    lymph node-1
    endometrium-1
    heart-1
    oral mucosa-1
    CD8-positive, alpha-beta thymocyte4
    common myeloid progenitor0
    tibial nerve-1
    plasma cell-1
    genetic_constraint
    syn0.11195000261068344
    mis4.47730016708374
    lof1
    Tissue-specific expression
    frontal lobe-1
    endothelial cell of umbilical vein (resting)2
    zone of skin0
    regulatory T cell1
    pancreas-1
    suprapubic skin-1
    temporal lobe-1
    parathyroid gland-1
    spleen-1
    Brodmann (1909) area 9-1
    breast-1
    Brodmann (1909) area 24-1
    alternatively activated macrophage2
    segmented neutrophil of bone marrow4
    placenta-1
    mature eosinophil1
    granulocyte monocyte progenitor cell0
    gall bladder-1
    esophagus muscularis mucosa-1
    seminal vesicle-1
    endocervix-1
    lower leg skin-1
    megakaryocyte-erythroid progenitor cell0
    endothelial cell of umbilical vein (proliferating)2
    CD8-positive, alpha-beta T cell3
    cerebral cortex-1
    CD34-negative, CD41-positive, CD42-positive megakaryocyte cell4
    hippocampus proper-1
    uterus-1
    CD4-positive, alpha-beta T cell3
    tonsil-1
    esophagus0
    transverse colon-1
    pituitary gland-1
    coronary artery-1
    memory B cell0
    sigmoid colon-1
    cerebellum-1
    erythroblast2
    prefrontal cortex-1
    nucleus accumbens-1
    adipose tissue0
    effector memory CD8-positive, alpha-beta T cell1
    vermiform appendix-1
    greater omentum-1
    hematopoietic multipotent progenitor cell1
    leukocyte2
    adrenal gland-1
    atrium auricular region-1
    thyroid gland0
    tibial artery-1
    common lymphoid progenitor3
    urinary bladder-1
    duodenum-1
    heart muscle-1
    small intestine-1
    neutrophilic metamyelocyte3
    minor salivary gland-1
    rectum0
    ovary-1
    substantia nigra-1
    subcutaneous adipose tissue-1
    class switched memory B cell1
    fallopian tube-1
    esophagus mucosa-1
    CD38-negative naive B cell0
    bronchus-1
    EBV-transformed lymphocyte0
    small intestine Peyer's patch-1
    kidney-1
    hippocampus-1
    macrophage1
    aorta-1
    skeletal muscle tissue-1
    CD3-positive, CD4-positive, CD8-positive, double positive thymocyte4
    caudate-putamen-1
    liver-1
    cytotoxic CD56-dim natural killer cell2
    mature neutrophil2
    hypothalamus-1
    transformed skin fibroblast-1
    bone marrow-1
    inflammatory macrophage0
    cortex of kidney-1
    lung-1
    epididymis-1
    abdomen-1
    saliva-secreting gland-1
    nasopharynx-1
    colon0
    cerebellar hemisphere-1
    stomach-1
    testis-1
    smooth muscle tissue0
    putamen-1
    CD4-positive, alpha-beta thymocyte5
    C1 segment of cervical spinal cord0
    blood-1
    hematopoietic stem cell1
    caudate nucleus-1
    amygdala-1
    brain0
    central memory CD8-positive, alpha-beta T cell1
    effector memory CD4-positive, alpha-beta T cell1
    ectocervix-1
    prostate gland-1
    conventional dendritic cell4
    central memory CD4-positive, alpha-beta T cell1
    heart left ventricle-1
    CD14-positive, CD16-negative classical monocyte0
    vagina-1
    esophagogastric junction-1
    lymph node-1
    endometrium-1
    heart-1
    oral mucosa-1
    CD8-positive, alpha-beta thymocyte4
    common myeloid progenitor0
    tibial nerve-1
    plasma cell-1
    Isoforms
    Isoforms - General localization
    CytoplasmNucleus
    Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta
    BioGRID Interactions
    Human interactions: 425 Non-human interactions: 95
    Human interactions (15 types, 425 partners)
    Affinity Capture-Luminescence — 3 genes
    SMAD3SMAD4SMURF2
    Affinity Capture-MS — 105 genes
    ARID1AARID1BASH2LATAD3BBCL7ABTBD9BUB3C1ORF116CADCCT6ACDC27CGACPSF7CREBBPCSNK1DCTNNB1CUL4ACUL4BDCAF7DDX3YDGKADHX8DNAJA2DOCK9DYRK1AEPB41L5ERBB2IPEZH2FAM83GFLOT1FLOT2FYNGSK3AGTF3C2GTF3C6HCFC1HDAC2HDAC4HINT3HSPA4ITGB4KLF5KMT2CLDLRAD4LEMD3MED15MED16MED17MED19MED20MED22MED25MED31MED4MED9MEN1MTMR4NCOA3OGTOPA1OTUB1PARK2PCBP1PCID2PLEKHA4PSPC1RIN1SGSHSIK3SKISKILSLC25A3SLC25A5SLC25A6SMAD1SMAD3SMAD4SMAD5SMAD9SMARCA4SMARCC1SMARCC2SMARCD2SMPDL3BSMURF2SNW1SNX27SQRDLTAF1TAF2TAF3TAF5TAF6TMED8TMOD1TRIM28TRIM33TRIM67U2AF2WDR82WRNIP1WWP2YAF2YY1ZFYVE9
    Affinity Capture-RNA — 2 genes
    DDX58ELAVL1
    Affinity Capture-Western — 106 genes
    ACVR1BACVR2BAKT1ANAPC10ATF3BRCA2CDC16CDC27CHUKCITED2CREBBPCSNK1DCTNNB1DAB2DOCK9EID2ELAC2EP300ERBB2IPESR1ETV4EZH2FHL1FHL2FHL3FOXH1FOXP1GLI1GTF2IGTF2IRD1HDAC1HGSHYAL2ING2INSRIRF3IRF7ITCHJUNKAT2AKAT2BKDM6BKLF5LEF1MAPTMED15MED24MED6MEF2AMETTL14METTL3MYCNEDD4NEDD4LNEDD9NFYCNOTCH4NUP214OTUB1OVOL2PIAS3PIAS4PIN1PMLPRDM16RBBP5RELBRGCCRNF111RUNX1RUNX2RUNX3S100A4SH2D2ASKISKILSMAD2SMAD3SMAD4SMAD6SMAD7SMARCA4SMURF1SMURF2SOX9SP1SPTBN1STRAPTCF12TGFBR1TGFBR2TGIF1TP53TRIM28TRIM33TSC2UCHL1USP15USP2USP7USP9XWWP1WWP2YAP1ZEB1ZFYVE9
    Biochemical Activity — 9 genes
    ACVR1BCAMK2GCDK2CDK4CDK8CDK9CSNK1DITCHTGFBR1
    Co-crystal Structure — 1 gene
    SMAD4
    Co-fractionation — 26 genes
    AP1M1ARID1BCAV1CREBBPCTNNB1HDAC1HMGA2MTA2NAA15NCOA3PARP1PMLPRKDCRBM14RELASMAD3SMAD4SMARCA4SMARCC1SMARCC2SNF8SUB1TGFBR1TRIM33XRCC6ZFYVE9
    Co-localization — 3 genes
    CAMK2ATGFBR1TP53
    FRET — 4 genes
    BECN1LATS2MYCSMAD1
    Phenotypic Enhancement — 2 genes
    SMAD3SNW1
    Phenotypic Suppression — 2 genes
    SMAD7STRAP
    Positive Genetic — 1 gene
    SPPL3
    Proximity Label-MS — 6 genes
    CCNFEPHA2OPTNRAB7ASNCATGOLN2
    Reconstituted Complex — 55 genes
    ANAPC10ANP32BANP32EATP5IBPTFCREBBPDAB2DVL1ELAC2ERBB2IPESR1FHL1FHL2FHL3FOXH1HDAC2HIPK2HYAL2INSRIRF7JUNKAT2BLCKLEF1MECOMMEF2AMEF2CMYCMYOCDNEDD4LNEFMNFIANUP214OTUB1PARD3PIAS3PIK3CAPIN1PTMSRHOASH2D2ASKISMAD4SMAD7SMURF2SNW1SOD1SP1STUB1SYT1TP53TUBA1BUCHL5YY1ZFYVE9
    Two-hybrid — 100 genes
    ABTB1AKT1ANAPC2ANK3ANTXR2BAZ1ABTBD2C22ORF46C9ORF156CISHCOPS5CORO2ACREBBPCSH1CSH2CUL5CYLC2CYP11A1DCUN1D1DNAJB5DNAJC7DOCK8DYNC1H1DYRK1AEEF1A1EIF3LEP300ETV4FAM161BFBP2FOXH1GATAD2BGFERHSD17B3INSRKHDRBS1KIAA1033KPNB1LAMA5LEMD3MAP2K1MLLT4MYCNAGKNCOA6NEDD4LOS9PAPOLAPAPPAPAXIP1PEX19PIAS4PLIN3POU2AF1PPP2R1APRKAR1APSAPPSG9PSMD11PSMD8RANBP6RANBP9RARBRASA1RNF123RNPC3ROCK1RPS14RPS27ARXRASKISKILSMAD1SMAD2SMAD3SMAD4SMAD9SMURF1SMURF2SNAPINSNIP1SNRNP70SNW1SP1SRIST13ST5TBC1D1TGIF1TGM2TRIM62UBA52UBR5XPAZEB2ZFYVE9ZMYND11ZNF41ZNF510ZNHIT6
    Non-human interactions (9 types, 95 partners)
    Affinity Capture-Luminescence — 27 genes
    ARHGEF1ARHGEF6ARHGEF7ARL4DCDC40FBXO3IRAK2LHX9LMO2MAP2K3NUAK2PPP2R2DRAB34RAB38RASD2RGS3RHEBL1RHOBTB1RHODRHOJRPS27ASMAD2SMAD3SQSTM1TRIM35UHMK1WWP2
    Affinity Capture-MS — 8 genes
    ALDH4A1BACH1E6FANCD2NSP16ABOTUB1PAXIP1RUNX1
    Affinity Capture-Western — 24 genes
    COL1A1COL3A1COL5A1DOK1E6E7GATA4HCVGP1KAP-ALPHA3KLF4LEF1MEDMED15MEF2ARNF111SKISMAD2SMAD4SMOXSNOOUBXVISWWTR1YAP1
    Co-localization — 3 genes
    E7EZH2-AKLF4
    PCA — 2 genes
    E6SMOX
    Phenotypic Enhancement — 4 genes
    BABOINRSMOXYKI
    Phenotypic Suppression — 8 genes
    BABOHPOINRMYOPLUMPTENSCGDELTASMOX
    Reconstituted Complex — 6 genes
    E7LEMD3SMAD2SOX9UBXZFP128
    Two-hybrid — 13 genes
    CG18095DE6EGFOXH1HOXA13HOXD13HR78SMAD2SMOXUBXZEB2ZEN
    SMAD3 • Entrez:4088 • UniProt:P84022
    Median span: null bp • Max span: null bp
    Functions (1)
    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator
    Diseases (2)
    Colorectal cancer Loeys-Dietz syndrome 3
    Pathways (54)
    Cytokine Signaling in Immune system Interleukin-1 family signaling SMAD2/3 Phosphorylation Motif Mutants in Cancer Developmental Biology Viral Infection Pathways Signaling by TGFBR3 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by Interleukins Deubiquitination Signaling by NOTCH TGF-beta receptor signaling activates SMADs Signaling by TGFB family members Loss of Function of TGFBR1 in Cancer RUNX3 regulates CDKN1A transcription SARS-CoV-1 targets host intracellular signalling and regulatory pathways Signaling by TGF-beta Receptor Complex TGFBR1 KD Mutants in Cancer Post-translational protein modification FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes TGFBR3 expression Disease Generic Transcription Pathway Metabolism of proteins Gene expression (Transcription) Signal Transduction SARS-CoV-1-host interactions FOXO-mediated transcription Infectious disease Gastrulation RNA Polymerase II Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of cell cycle genes Loss of Function of SMAD2/3 in Cancer SMAD4 MH2 Domain Mutants in Cancer Diseases of signal transduction by growth factor receptors and second messengers SARS-CoV Infections Formation of axial mesoderm SARS-CoV-1 Infection Germ layer formation at gastrulation Signaling by NOTCH4 Downregulation of TGF-beta receptor signaling Interleukin-37 signaling Formation of definitive endoderm RUNX3 regulates BCL2L11 (BIM) transcription Ub-specific processing proteases Loss of Function of SMAD4 in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Immune System SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation by RUNX3 Signaling by Activin Signaling by TGF-beta Receptor Complex in Cancer Signaling by NODAL
    GO annotations (134)
    C:SMAD protein complex C:chromatin C:ciliary basal body C:cytoplasm C:cytosol C:heteromeric SMAD protein complex C:intracellular membrane-bounded organelle C:nuclear inner membrane C:nucleoplasm C:nucleus C:plasma membrane C:receptor complex C:transcription regulator complex F:DEAD/H-box RNA helicase binding F:DNA binding F:DNA-binding transcription activator activity, RNA polymerase II-specific F:DNA-binding transcription factor activity F:DNA-binding transcription factor activity, RNA polymerase II-specific F:DNA-binding transcription factor binding F:DNA-binding transcription repressor activity F:I-SMAD binding F:R-SMAD binding F:RNA polymerase II cis-regulatory region sequence-specific DNA binding F:RNA polymerase II-specific DNA-binding transcription factor binding F:bHLH transcription factor binding F:beta-catenin binding F:chromatin DNA binding F:cis-regulatory region sequence-specific DNA binding F:co-SMAD binding F:collagen binding F:identical protein binding F:nuclear glucocorticoid receptor binding F:nuclear mineralocorticoid receptor binding F:nuclear receptor binding F:phosphatase binding F:promoter-specific chromatin binding F:protein homodimerization activity F:protein kinase binding F:sequence-specific DNA binding F:sterol response element binding F:transcription cis-regulatory region binding F:transcription coactivator binding F:transcription corepressor binding F:transforming growth factor beta receptor binding F:ubiquitin binding F:ubiquitin protein ligase binding F:zinc ion binding P:JNK cascade P:SMAD protein signal transduction P:T cell activation P:activin receptor signaling pathway P:adrenal gland development P:anatomical structure morphogenesis P:apoptotic signaling pathway P:cell differentiation P:cell population proliferation P:cell-cell junction organization P:cellular response to glucose stimulus P:cellular response to transforming growth factor beta stimulus P:cellular response to virus P:developmental growth P:embryonic cranial skeleton morphogenesis P:embryonic foregut morphogenesis P:embryonic pattern specification P:endoderm development P:extrinsic apoptotic signaling pathway P:heart looping P:immune response P:immune system development P:in utero embryonic development P:lens fiber cell differentiation P:liver development P:mesoderm formation P:negative regulation of apoptotic process P:negative regulation of cardiac muscle hypertrophy in response to stress P:negative regulation of cell differentiation P:negative regulation of cell growth P:negative regulation of cell population proliferation P:negative regulation of cytosolic calcium ion concentration P:negative regulation of fat cell differentiation P:negative regulation of gene expression P:negative regulation of inflammatory response P:negative regulation of lung blood pressure P:negative regulation of miRNA transcription P:negative regulation of ossification P:negative regulation of osteoblast differentiation P:negative regulation of osteoblast proliferation P:negative regulation of protein catabolic process P:negative regulation of transcription by RNA polymerase II P:negative regulation of wound healing P:nodal signaling pathway P:osteoblast development P:paraxial mesoderm morphogenesis P:pericardium development P:positive regulation of DNA-templated transcription P:positive regulation of SMAD protein signal transduction P:positive regulation of bone mineralization P:positive regulation of canonical Wnt signaling pathway P:positive regulation of cell migration P:positive regulation of chondrocyte differentiation P:positive regulation of epithelial to mesenchymal transition P:positive regulation of extracellular matrix assembly P:positive regulation of focal adhesion assembly P:positive regulation of gene expression P:positive regulation of interleukin-1 beta production P:positive regulation of miRNA transcription P:positive regulation of nitric oxide biosynthetic process P:positive regulation of positive chemotaxis P:positive regulation of protein import into nucleus P:positive regulation of stress fiber assembly P:positive regulation of transcription by RNA polymerase II P:positive regulation of transforming growth factor beta3 production P:primary miRNA processing P:protein stabilization P:regulation of DNA-templated transcription P:regulation of epithelial cell proliferation P:regulation of immune response P:regulation of miRNA transcription P:regulation of mitochondrial membrane potential P:regulation of striated muscle tissue development P:regulation of transcription by RNA polymerase II P:regulation of transforming growth factor beta receptor signaling pathway P:regulation of transforming growth factor beta2 production P:release of cytochrome c from mitochondria P:response to angiotensin P:response to hypoxia P:signal transduction involved in regulation of gene expression P:somitogenesis P:thyroid gland development P:transdifferentiation P:transforming growth factor beta receptor signaling pathway P:trophoblast cell migration P:ureteric bud development P:wound healing
    MSigDB
    MSigDB H — Hallmark gene sets (broad biological states/processes) (4)
    HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING
    MSigDB C1 — Positional gene sets (cytogenetic bands) (1)
    chr15q22
    MSigDB C2 — Curated gene sets (pathways/literature) (184)
    KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS
    MSigDB C3 — Regulatory target sets (TF & miRNA targets) (86)
    WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505
    MSigDB C4 — Computational gene sets (co-expression/other) (17)
    MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317
    MSigDB C6 — Oncogenic signatures (1)
    RPS14_DN.V1_UP
    MSigDB C7 — Immunologic signatures (126)
    GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP
    MSigDB C8 — Cell type signatures (single-cell) (10)
    FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE
    Open Targets
    is_essential: false
    Disease annotations (1218)
    Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm
    tissue_specific_expression
    breast0
    atrium auricular region1
    liver0
    skeletal muscle tissue1
    EBV-transformed lymphocyte0
    esophagus mucosa1
    macrophage-1
    adipose tissue0
    segmented neutrophil of bone marrow-1
    CD34-negative, CD41-positive, CD42-positive megakaryocyte cell-1
    class switched memory B cell0
    CD14-positive, CD16-negative classical monocyte3
    Brodmann (1909) area 90
    CD4-positive, alpha-beta thymocyte1
    zone of skin1
    leukocyte0
    nasopharynx-1
    tonsil0
    frontal lobe0
    cerebellar hemisphere-1
    putamen0
    hematopoietic stem cell-1
    effector memory CD4-positive, alpha-beta T cell0
    testis-1
    bronchus-1
    sigmoid colon0
    fallopian tube0
    plasma cell-1
    aorta0
    adrenal gland-1
    kidney0
    endometrium0
    smooth muscle tissue0
    tibial artery0
    prefrontal cortex0
    CD8-positive, alpha-beta T cell-1
    vermiform appendix0
    lymph node0
    duodenum0
    mature eosinophil0
    prostate gland1
    C1 segment of cervical spinal cord-1
    lung0
    inflammatory macrophage-1
    rectum0
    suprapubic skin0
    brain-1
    coronary artery0
    parathyroid gland-1
    Brodmann (1909) area 240
    esophagus muscularis mucosa0
    esophagus1
    transformed skin fibroblast1
    heart muscle-1
    pancreas0
    uterus0
    placenta0
    seminal vesicle-1
    hippocampus-1
    effector memory CD8-positive, alpha-beta T cell0
    endothelial cell of umbilical vein (resting)0
    minor salivary gland0
    endocervix1
    central memory CD8-positive, alpha-beta T cell0
    CD8-positive, alpha-beta thymocyte-1
    granulocyte monocyte progenitor cell-1
    caudate nucleus0
    amygdala0
    temporal lobe0
    substantia nigra-1
    abdomen-1
    common lymphoid progenitor0
    cerebral cortex0
    endothelial cell of umbilical vein (proliferating)0
    blood-1
    nucleus accumbens0
    stomach0
    oral mucosa-1
    mature neutrophil0
    central memory CD4-positive, alpha-beta T cell0
    bone marrow-1
    gall bladder1
    colon0
    cytotoxic CD56-dim natural killer cell-1
    pituitary gland0
    transverse colon0
    heart left ventricle0
    erythroblast-1
    vagina1
    ovary1
    megakaryocyte-erythroid progenitor cell-1
    subcutaneous adipose tissue1
    cerebellum-1
    hypothalamus-1
    common myeloid progenitor-1
    hematopoietic multipotent progenitor cell-1
    alternatively activated macrophage-1
    thyroid gland1
    lower leg skin0
    epididymis-1
    spleen0
    esophagogastric junction0
    greater omentum1
    memory B cell0
    hippocampus proper-1
    CD4-positive, alpha-beta T cell-1
    small intestine1
    conventional dendritic cell-1
    cortex of kidney0
    small intestine Peyer's patch0
    heart-1
    CD3-positive, CD4-positive, CD8-positive, double positive thymocyte-1
    caudate-putamen-1
    urinary bladder1
    ectocervix1
    regulatory T cell-1
    CD38-negative naive B cell1
    saliva-secreting gland0
    neutrophilic metamyelocyte-1
    tibial nerve0
    genetic_constraint
    syn-0.12650999426841736
    mis4.360300064086914
    lof0.9999799728393555
    Tissue-specific expression
    breast0
    atrium auricular region1
    liver0
    skeletal muscle tissue1
    EBV-transformed lymphocyte0
    esophagus mucosa1
    macrophage-1
    adipose tissue0
    segmented neutrophil of bone marrow-1
    CD34-negative, CD41-positive, CD42-positive megakaryocyte cell-1
    class switched memory B cell0
    CD14-positive, CD16-negative classical monocyte3
    Brodmann (1909) area 90
    CD4-positive, alpha-beta thymocyte1
    zone of skin1
    leukocyte0
    nasopharynx-1
    tonsil0
    frontal lobe0
    cerebellar hemisphere-1
    putamen0
    hematopoietic stem cell-1
    effector memory CD4-positive, alpha-beta T cell0
    testis-1
    bronchus-1
    sigmoid colon0
    fallopian tube0
    plasma cell-1
    aorta0
    adrenal gland-1
    kidney0
    endometrium0
    smooth muscle tissue0
    tibial artery0
    prefrontal cortex0
    CD8-positive, alpha-beta T cell-1
    vermiform appendix0
    lymph node0
    duodenum0
    mature eosinophil0
    prostate gland1
    C1 segment of cervical spinal cord-1
    lung0
    inflammatory macrophage-1
    rectum0
    suprapubic skin0
    brain-1
    coronary artery0
    parathyroid gland-1
    Brodmann (1909) area 240
    esophagus muscularis mucosa0
    esophagus1
    transformed skin fibroblast1
    heart muscle-1
    pancreas0
    uterus0
    placenta0
    seminal vesicle-1
    hippocampus-1
    effector memory CD8-positive, alpha-beta T cell0
    endothelial cell of umbilical vein (resting)0
    minor salivary gland0
    endocervix1
    central memory CD8-positive, alpha-beta T cell0
    CD8-positive, alpha-beta thymocyte-1
    granulocyte monocyte progenitor cell-1
    caudate nucleus0
    amygdala0
    temporal lobe0
    substantia nigra-1
    abdomen-1
    common lymphoid progenitor0
    cerebral cortex0
    endothelial cell of umbilical vein (proliferating)0
    blood-1
    nucleus accumbens0
    stomach0
    oral mucosa-1
    mature neutrophil0
    central memory CD4-positive, alpha-beta T cell0
    bone marrow-1
    gall bladder1
    colon0
    cytotoxic CD56-dim natural killer cell-1
    pituitary gland0
    transverse colon0
    heart left ventricle0
    erythroblast-1
    vagina1
    ovary1
    megakaryocyte-erythroid progenitor cell-1
    subcutaneous adipose tissue1
    cerebellum-1
    hypothalamus-1
    common myeloid progenitor-1
    hematopoietic multipotent progenitor cell-1
    alternatively activated macrophage-1
    thyroid gland1
    lower leg skin0
    epididymis-1
    spleen0
    esophagogastric junction0
    greater omentum1
    memory B cell0
    hippocampus proper-1
    CD4-positive, alpha-beta T cell-1
    small intestine1
    conventional dendritic cell-1
    cortex of kidney0
    small intestine Peyer's patch0
    heart-1
    CD3-positive, CD4-positive, CD8-positive, double positive thymocyte-1
    caudate-putamen-1
    urinary bladder1
    ectocervix1
    regulatory T cell-1
    CD38-negative naive B cell1
    saliva-secreting gland0
    neutrophilic metamyelocyte-1
    tibial nerve0
    Isoforms
    Isoforms - General localization
    CytoplasmNucleus
    Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)
    BioGRID Interactions
    Human interactions: 591 Non-human interactions: 77
    Human interactions (19 types, 591 partners)
    Affinity Capture-Luminescence — 7 genes
    BAG3HIF1ASMAD2SMAD4SMURF1SMURF2SP1
    Affinity Capture-MS — 96 genes
    ARID1AATG14ATG16L1ATXN2LBUB3C1ORF116CD6CDK11ACHD8CICCREBBPCSNK1DCTNNB1DCAF4DCAF7DDX3XDDX3YDDX4DHX8DNAJA2DOCK9DYRK1ADZIP3EPB41L5ERBB2IPEVA1BEZH2FAM83GFURINHINT3HSPA4IRF7IRS1ITGB4KAT6AKCTD16LACRTLDLRAD4LEMD3LRCH1LSRMAP2K3MAPK1MED16MED4NCOA3NF2OPA1OTUB1OTUD1PABPC1PARK2PJA1PLEKHA4PPIEPRNPPSPC1PTPN6RAB11FIP5RPL3RPL4RPSAP15SIK3SLC25A12SLC9A3R2SMAD1SMAD2SMAD4SMAD5SMAD9SMARCA4SMARCC1SMARCC2SMURF2SNW1SQRDLSUZ12TAF1TAF2TCP1TGFB1TMEM192TRIM33TRIM67TRIP4U2AF2UGT1A10USP33USP7VAV2WWP2YTHDF2YY1ZFP69BZFYVE9ZRANB1
    Affinity Capture-RNA — 2 genes
    DDX58TRIM25
    Affinity Capture-Western — 167 genes
    ACTBACVR1BAKT1ANAPC10ARATF2ATF3BACH1BRCA1BRCA2BTRCCBLCDC16CDC25ACDC27CDKN1ACEBPDCHRDCHUKCITED2CREBBPCSNK1DCSNK1G2CTCFCTNNB1CUL1DAB2DACH1DEDDDOCK9E2F4EID2ELAC2EP300ERBB2IPESR1EZH2FHL1FHL2FHL3FOSFOXH1FOXL2FOXM1FOXO1FOXO3FOXO4GRIP1GSK3BHDAC4HDAC5HGSHIF1AHNF4AHYAL2ID1IRF7JUNKAT2AKAT2BKAT6AKDM5CKDM6BKLF5KPNB1LEF1MAFKMECOMMED15MED24MED6MEN1METTL14METTL3MKL1MYCMYD88MYOCDNCOA1NEDD4NEDD4LNEDD9NFICNFYCNOTCH1NOTCH4NR3C1NR4A1NUP214OTUB1OTUD1OVOL2PAX6PCK2PDLIM5PIAS3PIAS4PIN1PITX1PITX2PMLPPARGPPP1R12CPRDM16PRTN3RARARBBP5RBL1RBX1RELBRGCCRNF111RNF31RUNX1RUNX2RUNX3S100A4SETD2SH2D2ASKISKILSMAD2SMAD3SMAD4SMAD7SMARCA4SMARCC2SMURF1SMURF2SOX9SP1SPTBN1SQSTM1SREBF2SRYSTRAPSTUB1SUV39H1TCF12TGFB1I1TGFBR1TGFBR2TGIF1TGIF2TOB1TP53TRIB3TRIM24TRIM33TRIM62TSC2TSC22D4UCHL1UCHL5USP15USP2USP7USP9XWWOXWWP1WWP2YAP1ZC3H12AZEB1ZEB2ZFYVE9ZMIZ1
    Biochemical Activity — 14 genes
    CDK2CDK4CDK8CDK9CSNK1DCSNK1G2MAPK1NEDD4NEDD4LOTUB1TGFBR1USP15USP7WWP2
    Co-crystal Structure — 3 genes
    SMAD3SMAD4ZFYVE9
    Co-fractionation — 40 genes
    ALKBH2ANAPC10APPARID1BCDH1CREBBPCTCFCTNNB1CUL1DDR1FOXO3HDAC1HMGA2IGF1RITGB1JUNDMTA2NAA15NT5DC3PARP1PRKDCRBM14RBX1RELARIPK1RNMTSIN3ASKP1SMAD2SMARCA4SMARCC1SMARCC2SNF8SP1SUB1TRIM33XRCC5XRCC6ZFHX3ZFYVE9
    Co-localization — 15 genes
    AKT1BMP7CAMK2GCDK2CDK4EPAS1ETS1FOXO3HIF1AIRF7MAP3K7MAPK8MAXTP53TRIM62
    Cross-Linking-MS (XL-MS) — 1 gene
    RPL10A
    FRET — 2 genes
    SMAD4STUB1
    PCA — 2 genes
    SMAD4SMAD7
    Phenotypic Enhancement — 3 genes
    HIF1ASMAD2SNW1
    Phenotypic Suppression — 2 genes
    SMAD7STRAP
    Positive Genetic — 1 gene
    JAK1
    Protein-peptide — 6 genes
    CREBBPFOXH1ITCHLEF1NEDD4PIN1
    Protein-RNA — 1 gene
    LINC00941
    Proximity Label-MS — 1 gene
    NFIA
    Reconstituted Complex — 98 genes
    ANAPC10APPARATF2ATF3BPTFBRCA1BRCA2CEBPACEBPBCEBPDCITED2CREBBPCTCFDAB2DDX5DEDDDNMT3LDVL1E2F4EID2EIF4BEP300ERBB2IPFHL1FHL2FHL3FOSFOXH1FOXM1GSK3BHDAC1HDAC4HDAC5HIF1AHIPK2HNF4AHYAL2IRF7ITCHJUNJUNBJUNDKAT2BKAT6AKPNB1LCKLEF1LEMD3MAXMDM4MECOMMYCMYOCDNEDD4NEDD4LNEDD9NFIANOTCH1NR3C1NUP153NUP214PARD3PIAS2PIAS3PIAS4PIK3CAPIN1RBL1RUNX2S100A4SH2D2ASIN3ASKISKILSMAD3SMAD4SMURF2SNW1SP1STUB1TFE3TGFB1I1TGFBR1TGIF1TP53TRIM24TRIM33TRIM62TSC2UCHL5USP15VDRWWOXXPO6YY1ZFYVE9ZMIZ1
    Two-hybrid — 130 genes
    AATFAESANK3APMAPAPOBARATF2BLZF1C10ORF54C14ORF105CCDC33CDC25ACFDP1CFHCFLARCHRDCORO1ACPSF7CPTPCREBBPCRXCSH2CXXC5CYP11A1DEDDDNAJB4DNAJB5EBI3EP300EPAS1FAM90A1FBLN1FLI1FLNAFOSFOXH1GGA1GIT2GMEB1HDAC1HEY1HEYLHIF1AHIVEP1HNRNPKHOXC11HPISL1JUNJUNBKANSL1KDM2AKMT2BLBPMCM3APMEOX2MTF2MYCMYD88NCOA6NEDD4NEDD9NR4A1PAPPAPARP4PCDH1PCK2PHC2PIAS4PIN1PLAG1PLAGL1PLGPPP1R12CPPP2R1APRDM4PROX1PSMB1PSMD11RANBP9RBPMSRBX1RCVRNRELARIOK2RNF31RPA1RPLP0SAP130SBK3SERTAD1SETD2SKILSMAD1SMAD2SMAD3SMAD4SMURF1SMURF2SNRNP70SNW1SP1SQSTM1SS18L1ST6GALNAC2SVEP1TANKTDP2TEKT4TFTGM2TLR4TMED1TSC22D4UBQLN4USP7VDRWWP1WWP2XRCC6ZBTB16ZBTB3ZC3H12AZCCHC14ZEB2ZFYVE9ZMYND11ZNF329ZNF774ZNF83
    Non-human interactions (11 types, 77 partners)
    Affinity Capture-Luminescence — 17 genes
    ARHGEF6ARHGEF7CLASRPFBXO3GSCMAP2K3PPP2R2DRAB38RASD2RGS3RRAS2SMAD2SMAD3SQSTM1TRIM35WEE1WWP2
    Affinity Capture-MS — 5 genes
    ATG16L1E6NSP6OTUB1SMAD3
    Affinity Capture-Western — 28 genes
    AXIN1COL1A1COL3A1COL5A1DDX5DOK1E6E7EP300GATA4GNB2L1HCVGP1HDAC4KLF4MED15MELKNRNF111SKISMAD3SMAD3ASMAD4TGFB1I1TOB1TOB1ATOB1BVDRZEB1
    Co-localization — 2 genes
    E7N
    PCA — 1 gene
    E6
    Phenotypic Enhancement — 1 gene
    SMAD3A
    Phenotypic Suppression — 1 gene
    SMAD3A
    Proximity Label-MS — 1 gene
    M
    Reconstituted Complex — 9 genes
    E6E7GATA4NSIN3ASMAD3SOX9YAP1ZFP128
    Synthetic Growth Defect — 1 gene
    MMP9
    Two-hybrid — 11 genes
    DVL1E6ERBB2IPFOXH1GATA4HCVGP1JUNMAGI2PARD3SMAD3ZEB2
    ChEMBL Gene-Centric Data
    Protein Structure
    \\n\\n \\n \\n\\n\\n\\n \\n
    \\n \\n
    \\n \\n \\n\\n \\n \\n\\n \\n \\n \\n\\n \\n
    \\n \\n \\n
    \\n
    \\n\\n \\n
    \\n Min\\n \\n Max\\n
    \\n\\n \\n
    \\n \\n
    \\n \\n
    \\n\\n \\n
    \\n \\n CysDB:\\n \\n\\n [\\n\\n \\n \\n\\n |\\n\\n \\n \\n\\n |\\n\\n \\n \\n\\n |\\n\\n \\n Cys @ Act. Site\\n \\n or Near\\n \\n\\n |\\n\\n \\n Cys @ Bind. Site\\n \\n or Near\\n \\n\\n ]\\n
    \\n
    \\n
    \\n\\n \\n
    \\n\\n\\n\",\"chembl_html\":\"\\n\\n\\n \\n ChEMBL Viewer - SMAD2, SMAD3\\n\\n \\n \\n\\n \\n \\n\\n \\n \\n\\n\\n\\n \\n
    \\n
    \\n \\n \\n
    \\n
    \\n\\n \\n
    \\n\\n \\n
    \\n

    \\n \\n FDA-approved Drugs\\n \\n

    \\n
    \\n \\n \\n \\n \\n \\n \\n \\n \\n \\n \\n \\n \\n
    ChEMBL ID / NameMolecule TypeFirst ApprovalIndicationsMechanism2D Structure
    \\n
    \\n
    \\n\\n \\n
    \\n

    \\n \\n Clinical & Preclinical Trials\\n \\n

    \\n
    \\n \\n \\n \\n \\n \\n \\n \\n \\n \\n \\n
    ChEMBL IDMolecule TypePhase2D Structure
    \\n
    \\n
    \\n\\n \\n
    \\n

    \\n \\n Bioactivity Evidence\\n \\n

    \\n
    \\n \\n \\n \\n \\n \\n \\n \\n \\n \\n \\n
    ChEMBL IDMolecule TypeEvidence2D Structure
    \\n
    \\n
    \\n\\n
    \\n\\n\\n\",\"drug_central_html\":\"\",\"aa_seq_html\":\"\",\"text_notes\":[]}")); try{ LOCAL_FILES.clear(); for (const [k, v] of JSON.parse(JSON.parse("[[\"20251224-191245_ui/variants/variants.csv\",\"variant_id,organism,primary_build,primary_chrom,primary_pos,n_related_genes,n_traits,n_af_freqs,n_func_pred_genes,tools_run,has_text_summary\\r\\n\"],[\"20251224-191245_ui/variants/summaries.csv\",\"variant_id,summary_text\\r\\n\"],[\"20251224-191245_ui/variants/locations.csv\",\"variant_id,build,chrom,pos,ref,alt\\r\\n\"],[\"20251224-191245_ui/variants/per_gene_context.csv\",\"variant_id,gene,context,variant_category\\r\\n\"],[\"20251224-191245_ui/variants/functional_predictions.csv\",\"variant_id,gene,tool,score\\r\\n\"],[\"20251224-191245_ui/variants/allele_frequencies.csv\",\"variant_id,source,population,af,ac,an,raw_json\\r\\n\"],[\"20251224-191245_ui/variants/per_gene_traits.csv\",\"variant_id,gene,trait,raw_json\\r\\n\"],[\"20251224-191245_ui/demo.json\",\"{\\n \\\"messages\\\": [\\n {\\n \\\"role\\\": \\\"user\\\",\\n \\\"content\\\": \\\"Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues\\\"\\n },\\n {\\n \\\"role\\\": \\\"user\\\",\\n \\\"content\\\": \\\"Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues\\\"\\n }\\n ],\\n \\\"genes\\\": [\\n \\\"SMAD2\\\",\\n \\\"SMAD3\\\"\\n ],\\n \\\"traits\\\": [],\\n \\\"proteins\\\": [],\\n \\\"drugs\\\": [],\\n \\\"transcripts\\\": [],\\n \\\"variants\\\": {},\\n \\\"chr_pos_variants\\\": {},\\n \\\"gene_level_gencode\\\": {},\\n \\\"prompt\\\": \\\"\\\",\\n \\\"mc_setup\\\": false,\\n \\\"aa_sequences\\\": [],\\n \\\"aa_seq_result\\\": {},\\n \\\"aa_seq_summary\\\": \\\"\\\",\\n \\\"gene_entities\\\": {\\n \\\"SMAD2\\\": {\\n \\\"identifiers\\\": {\\n \\\"symbol\\\": \\\"SMAD2\\\",\\n \\\"entrez_id\\\": \\\"4087\\\",\\n \\\"uniprot_id\\\": \\\"Q15796\\\",\\n \\\"ensembl_id\\\": null,\\n \\\"aliases\\\": [],\\n \\\"gene_type\\\": null\\n },\\n \\\"location\\\": null,\\n \\\"annotations\\\": {\\n \\\"go_annotations\\\": [\\n \\\"C:SMAD protein complex\\\",\\n \\\"C:activin responsive factor complex\\\",\\n \\\"C:chromatin\\\",\\n \\\"C:cytoplasm\\\",\\n \\\"C:cytosol\\\",\\n \\\"C:heteromeric SMAD protein complex\\\",\\n \\\"C:homomeric SMAD protein complex\\\",\\n \\\"C:intracellular membrane-bounded organelle\\\",\\n \\\"C:nucleoplasm\\\",\\n \\\"C:nucleus\\\",\\n \\\"C:protein-containing complex\\\",\\n \\\"C:transcription regulator complex\\\",\\n \\\"F:DNA-binding transcription activator activity, RNA polymerase II-specific\\\",\\n \\\"F:DNA-binding transcription factor activity\\\",\\n \\\"F:DNA-binding transcription factor activity, RNA polymerase II-specific\\\",\\n \\\"F:DNA-binding transcription factor binding\\\",\\n \\\"F:I-SMAD binding\\\",\\n \\\"F:R-SMAD binding\\\",\\n \\\"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding\\\",\\n \\\"F:RNA polymerase II-specific DNA-binding transcription factor binding\\\",\\n \\\"F:SMAD binding\\\",\\n \\\"F:chromatin binding\\\",\\n \\\"F:cis-regulatory region sequence-specific DNA binding\\\",\\n \\\"F:co-SMAD binding\\\",\\n \\\"F:disordered domain specific binding\\\",\\n \\\"F:double-stranded DNA binding\\\",\\n \\\"F:identical protein binding\\\",\\n \\\"F:metal ion binding\\\",\\n \\\"F:phosphatase binding\\\",\\n \\\"F:tau protein binding\\\",\\n \\\"F:transforming growth factor beta receptor binding\\\",\\n \\\"F:type I transforming growth factor beta receptor binding\\\",\\n \\\"F:ubiquitin protein ligase binding\\\",\\n \\\"P:DNA-templated transcription\\\",\\n \\\"P:SMAD protein signal transduction\\\",\\n \\\"P:activin receptor signaling pathway\\\",\\n \\\"P:anatomical structure morphogenesis\\\",\\n \\\"P:anterior/posterior pattern specification\\\",\\n \\\"P:aortic valve morphogenesis\\\",\\n \\\"P:cell differentiation\\\",\\n \\\"P:cell fate commitment\\\",\\n \\\"P:cell population proliferation\\\",\\n \\\"P:determination of left/right asymmetry in lateral mesoderm\\\",\\n \\\"P:embryonic cranial skeleton morphogenesis\\\",\\n \\\"P:embryonic foregut morphogenesis\\\",\\n \\\"P:endocardial cushion morphogenesis\\\",\\n \\\"P:endoderm formation\\\",\\n \\\"P:gastrulation\\\",\\n \\\"P:in utero embryonic development\\\",\\n \\\"P:insulin secretion\\\",\\n \\\"P:intracellular signal transduction\\\",\\n \\\"P:lung development\\\",\\n \\\"P:mesoderm formation\\\",\\n \\\"P:negative regulation of DNA-templated transcription\\\",\\n \\\"P:negative regulation of cell differentiation\\\",\\n \\\"P:negative regulation of ossification\\\",\\n \\\"P:nodal signaling pathway\\\",\\n \\\"P:odontoblast differentiation\\\",\\n \\\"P:organ growth\\\",\\n \\\"P:pancreas development\\\",\\n \\\"P:paraxial mesoderm morphogenesis\\\",\\n \\\"P:pericardium development\\\",\\n \\\"P:positive regulation of BMP signaling pathway\\\",\\n \\\"P:positive regulation of DNA-templated transcription\\\",\\n \\\"P:positive regulation of epithelial to mesenchymal transition\\\",\\n \\\"P:positive regulation of gene expression\\\",\\n \\\"P:positive regulation of transcription by RNA polymerase II\\\",\\n \\\"P:post-embryonic development\\\",\\n \\\"P:primary miRNA processing\\\",\\n \\\"P:pulmonary valve morphogenesis\\\",\\n \\\"P:regulation of DNA-templated transcription\\\",\\n \\\"P:regulation of transforming growth factor beta receptor signaling pathway\\\",\\n \\\"P:response to cholesterol\\\",\\n \\\"P:response to glucose\\\",\\n \\\"P:secondary palate development\\\",\\n \\\"P:transforming growth factor beta receptor signaling pathway\\\",\\n \\\"P:trophoblast cell migration\\\",\\n \\\"P:ureteric bud development\\\",\\n \\\"P:zygotic specification of dorsal/ventral axis\\\"\\n ],\\n \\\"functions\\\": [\\n \\\"Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma\\\"\\n ],\\n \\\"diseases\\\": [\\n \\\"Congenital heart defects, multiple types, 8, with or without heterotaxy\\\",\\n \\\"Loeys-Dietz syndrome 6\\\"\\n ],\\n \\\"pathways\\\": [\\n \\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\",\\n \\\"Developmental Biology\\\",\\n \\\"Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer\\\",\\n \\\"Deubiquitination\\\",\\n \\\"TGF-beta receptor signaling activates SMADs\\\",\\n \\\"Signaling by TGFB family members\\\",\\n \\\"Loss of Function of TGFBR1 in Cancer\\\",\\n \\\"Signaling by TGF-beta Receptor Complex\\\",\\n \\\"TGFBR1 KD Mutants in Cancer\\\",\\n \\\"Post-translational protein modification\\\",\\n \\\"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes\\\",\\n \\\"Disease\\\",\\n \\\"Generic Transcription Pathway\\\",\\n \\\"Metabolism of proteins\\\",\\n \\\"Gene expression (Transcription)\\\",\\n \\\"Signal Transduction\\\",\\n \\\"FOXO-mediated transcription\\\",\\n \\\"Gastrulation\\\",\\n \\\"RNA Polymerase II Transcription\\\",\\n \\\"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription\\\",\\n \\\"FOXO-mediated transcription of cell cycle genes\\\",\\n \\\"Loss of Function of SMAD2/3 in Cancer\\\",\\n \\\"Transcriptional regulation of pluripotent stem cells\\\",\\n \\\"SMAD4 MH2 Domain Mutants in Cancer\\\",\\n \\\"Diseases of signal transduction by growth factor receptors and second messengers\\\",\\n \\\"Formation of axial mesoderm\\\",\\n \\\"Germ layer formation at gastrulation\\\",\\n \\\"Downregulation of TGF-beta receptor signaling\\\",\\n \\\"Formation of definitive endoderm\\\",\\n \\\"Ub-specific processing proteases\\\",\\n \\\"Loss of Function of SMAD4 in Cancer\\\",\\n \\\"Downregulation of SMAD2/3:SMAD4 transcriptional activity\\\",\\n \\\"SMAD2/3 MH2 Domain Mutants in Cancer\\\",\\n \\\"Signaling by Activin\\\",\\n \\\"Signaling by TGF-beta Receptor Complex in Cancer\\\",\\n \\\"Signaling by NODAL\\\"\\n ],\\n \\\"cell_localizations\\\": [],\\n \\\"predicted_go\\\": [\\n \\\"regulation of production of miRNAs involved in gene silencing by miRNA\\\",\\n \\\"transmembrane receptor protein serine/threonine kinase signaling pathway\\\",\\n \\\"positive regulation of transcription from RNA polymerase II promoter in response to stress\\\",\\n \\\"negative regulation of MAPK cascade\\\",\\n \\\"negative regulation of protein phosphorylation\\\",\\n \\\"negative regulation of protein modification process\\\",\\n \\\"regulation of transcription from RNA polymerase II promoter in response to stress\\\",\\n \\\"negative regulation of DNA binding transcription factor activity\\\",\\n \\\"positive regulation of pathway-restricted SMAD protein phosphorylation\\\",\\n \\\"negative regulation of phosphorylation\\\",\\n \\\"regulation of kidney development\\\",\\n \\\"regulation of epidermis development\\\",\\n \\\"positive regulation of protein modification by small protein conjugation or removal\\\",\\n \\\"I-kappaB kinase/NF-kappaB signaling\\\",\\n \\\"regulation of transforming growth factor beta2 production\\\",\\n \\\"nodal signaling pathway\\\",\\n \\\"transforming growth factor beta receptor signaling pathway\\\",\\n \\\"gene silencing by miRNA\\\",\\n \\\"regulation of pathway-restricted SMAD protein phosphorylation\\\",\\n \\\"negative regulation of activin receptor signaling pathway\\\",\\n \\\"regulation of SMAD protein signal transduction\\\",\\n \\\"negative regulation of pathway-restricted SMAD protein phosphorylation\\\",\\n \\\"regulation of gene silencing by miRNA\\\",\\n \\\"negative regulation of cellular response to growth factor stimulus\\\",\\n \\\"regulation of epidermal cell differentiation\\\",\\n \\\"proteasomal protein catabolic process\\\",\\n \\\"regulation of production of small RNA involved in gene silencing by RNA\\\",\\n \\\"cellular response to transforming growth factor beta stimulus\\\",\\n \\\"positive regulation of protein catabolic process\\\",\\n \\\"regulation of protein modification by small protein conjugation or removal\\\",\\n \\\"positive regulation of MAPK cascade\\\",\\n \\\"regulation of DNA-templated transcription in response to stress\\\",\\n \\\"positive regulation of I-kappaB kinase/NF-kappaB signaling\\\",\\n \\\"negative regulation of fat cell differentiation\\\",\\n \\\"pathway-restricted SMAD protein phosphorylation\\\",\\n \\\"negative regulation of cell proliferation\\\",\\n \\\"regulation of transforming growth factor beta receptor signaling pathway\\\",\\n \\\"cellular response to BMP stimulus\\\",\\n \\\"regulation of cellular response to transforming growth factor beta stimulus\\\",\\n \\\"regulation of DNA binding transcription factor activity\\\",\\n \\\"regulation of BMP signaling pathway\\\",\\n \\\"negative regulation of intracellular signal transduction\\\",\\n \\\"regulation of posttranscriptional gene silencing\\\",\\n \\\"activation of MAPKK activity\\\",\\n \\\"negative regulation of transcription by competitive promoter binding\\\",\\n \\\"response to BMP\\\",\\n \\\"regulation of protein ubiquitination\\\",\\n \\\"histone modification\\\",\\n \\\"regulation of gene silencing by RNA\\\",\\n \\\"BMP signaling pathway\\\",\\n \\\"stress-activated MAPK cascade\\\",\\n \\\"positive regulation of SMAD protein signal transduction\\\",\\n \\\"response to transforming growth factor beta\\\",\\n \\\"regulation of vasculature development\\\",\\n \\\"positive regulation of epidermal cell differentiation\\\",\\n \\\"negative regulation of androgen receptor signaling pathway\\\",\\n \\\"SMAD protein signal transduction\\\",\\n \\\"negative regulation of myosin-light-chain-phosphatase activity\\\",\\n \\\"positive regulation of DNA binding transcription factor activity\\\",\\n \\\"regulation of angiogenesis\\\",\\n \\\"regulation of cellular response to growth factor stimulus\\\",\\n \\\"regulation of transmembrane receptor protein serine/threonine kinase signaling pathway\\\",\\n \\\"regulation of keratinocyte differentiation\\\",\\n \\\"activin receptor signaling pathway\\\",\\n \\\"regulation of epithelial cell differentiation\\\",\\n \\\"positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway\\\",\\n \\\"positive regulation of proteasomal ubiquitin-dependent protein catabolic process\\\",\\n \\\"regulation of stress-activated MAPK cascade\\\",\\n \\\"negative regulation of BMP signaling pathway\\\",\\n \\\"positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus\\\",\\n \\\"SMAD protein complex assembly\\\"\\n ],\\n \\\"predicted_disease\\\": [\\n \\\"aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709)\\\"\\n ]\\n },\\n \\\"interactions\\\": {\\n \\\"human_interactions\\\": {\\n \\\"Affinity Capture-Luminescence\\\": [\\n \\\"SMAD3\\\",\\n \\\"SMAD4\\\",\\n \\\"SMURF2\\\"\\n ],\\n \\\"Affinity Capture-MS\\\": [\\n \\\"ARID1A\\\",\\n \\\"ARID1B\\\",\\n \\\"ASH2L\\\",\\n \\\"ATAD3B\\\",\\n \\\"BCL7A\\\",\\n \\\"BTBD9\\\",\\n \\\"BUB3\\\",\\n \\\"C1ORF116\\\",\\n \\\"CAD\\\",\\n \\\"CCT6A\\\",\\n \\\"CDC27\\\",\\n \\\"CGA\\\",\\n \\\"CPSF7\\\",\\n \\\"CREBBP\\\",\\n \\\"CSNK1D\\\",\\n \\\"CTNNB1\\\",\\n \\\"CUL4A\\\",\\n \\\"CUL4B\\\",\\n \\\"DCAF7\\\",\\n \\\"DDX3Y\\\",\\n \\\"DGKA\\\",\\n \\\"DHX8\\\",\\n \\\"DNAJA2\\\",\\n \\\"DOCK9\\\",\\n \\\"DYRK1A\\\",\\n \\\"EPB41L5\\\",\\n \\\"ERBB2IP\\\",\\n \\\"EZH2\\\",\\n \\\"FAM83G\\\",\\n \\\"FLOT1\\\",\\n \\\"FLOT2\\\",\\n \\\"FYN\\\",\\n \\\"GSK3A\\\",\\n \\\"GTF3C2\\\",\\n \\\"GTF3C6\\\",\\n \\\"HCFC1\\\",\\n \\\"HDAC2\\\",\\n \\\"HDAC4\\\",\\n \\\"HINT3\\\",\\n \\\"HSPA4\\\",\\n \\\"ITGB4\\\",\\n \\\"KLF5\\\",\\n 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\\\"WP_NEOVASCULARIZATION_PROCESSES\\\",\\n \\\"REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER\\\",\\n \\\"PUJANA_ATM_PCC_NETWORK\\\",\\n \\\"TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C\\\",\\n \\\"KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY\\\",\\n \\\"PID_SMAD2_3PATHWAY\\\",\\n \\\"PUJANA_BRCA1_PCC_NETWORK\\\",\\n \\\"KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY\\\",\\n \\\"PULVER_FOREY_CELLCYCLE_PEAKING_S2\\\",\\n \\\"DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP\\\",\\n \\\"REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER\\\",\\n \\\"WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING\\\",\\n \\\"PID_TGFBR_PATHWAY\\\",\\n \\\"REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS\\\",\\n \\\"WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY\\\",\\n \\\"WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM\\\",\\n \\\"REACTOME_FOXO_MEDIATED_TRANSCRIPTION\\\",\\n \\\"KEGG_COLORECTAL_CANCER\\\",\\n \\\"REACTOME_SIGNALING_BY_ACTIVIN\\\",\\n \\\"SHEN_SMARCA2_TARGETS_UP\\\",\\n 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\\\"MIR340_5P\\\",\\n \\\"MIR548AG\\\",\\n \\\"MIR5584_5P\\\",\\n \\\"MIR4422\\\",\\n \\\"MIR8085\\\",\\n \\\"MIR30A_3P\\\",\\n \\\"MIR497_3P\\\",\\n \\\"MIR6074\\\",\\n \\\"MIR208A_5P\\\",\\n \\\"MIR4298\\\",\\n \\\"MIR6134\\\",\\n \\\"MIR365B_5P\\\",\\n \\\"NFY_Q6_01\\\",\\n \\\"AHRR_TARGET_GENES\\\",\\n \\\"MIR6878_5P\\\",\\n \\\"MIR4761_5P\\\",\\n \\\"AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D\\\",\\n \\\"MIR5590_3P\\\",\\n \\\"MIR103A_1_5P\\\",\\n \\\"MIR4305\\\",\\n \\\"MIR365A_5P\\\",\\n \\\"MIR1302\\\",\\n \\\"ZNF592_TARGET_GENES\\\",\\n \\\"MAX_01\\\",\\n \\\"MIR374A_5P\\\",\\n \\\"MIR769_5P\\\",\\n \\\"MIR4496\\\",\\n \\\"MIR30E_3P\\\",\\n \\\"ZNF282_TARGET_GENES\\\",\\n \\\"CAGCACT_MIR5123P\\\",\\n \\\"TOP2B_TARGET_GENES\\\",\\n \\\"MIR5002_5P\\\",\\n \\\"MIR656_3P\\\",\\n \\\"MIR302A_5P\\\",\\n \\\"MYCMAX_01\\\",\\n \\\"MIR520E_5P\\\",\\n \\\"MIR374B_3P\\\",\\n \\\"MIR551B_5P\\\",\\n \\\"HMX1_01\\\",\\n \\\"MIR30D_3P\\\",\\n \\\"MIR12124\\\",\\n \\\"NFY_01\\\",\\n \\\"MIR4799_5P\\\",\\n \\\"GGTGTGT_MIR329\\\",\\n \\\"MIR607\\\",\\n \\\"GGGTGGRR_PAX4_03\\\",\\n \\\"MIR4724_3P\\\",\\n \\\"ZNF407_TARGET_GENES\\\",\\n \\\"MIR520D_5P\\\",\\n \\\"MIR548AI_MIR570_5P\\\",\\n \\\"AACTTT_UNKNOWN\\\",\\n \\\"MIR302B_5P\\\",\\n \\\"MIR4735_3P\\\",\\n \\\"CCAATNNSNNNGCG_UNKNOWN\\\",\\n \\\"MIR18A_5P_MIR18B_5P\\\",\\n \\\"MIR103A_2_5P\\\",\\n \\\"MIR548BA\\\",\\n \\\"MIR1910_3P\\\",\\n \\\"MIR34C_3P\\\",\\n \\\"MIR3121_3P\\\",\\n \\\"MIR142_5P\\\",\\n \\\"MIR3122\\\",\\n \\\"MIR128_3P\\\",\\n \\\"GCTNWTTGK_UNKNOWN\\\",\\n \\\"CEBPZ_TARGET_GENES\\\",\\n \\\"SMARCA1_TARGET_GENES\\\",\\n \\\"GCACCTT_MIR18A_MIR18B\\\",\\n \\\"MIR3913_3P\\\",\\n \\\"MIR190B_3P\\\",\\n \\\"ALPHACP1_01\\\",\\n \\\"MIR4719\\\",\\n \\\"MIR3692_5P\\\",\\n \\\"MIR1237_3P\\\",\\n \\\"MIR5692B_MIR5692C\\\",\\n \\\"MIR5004_5P\\\",\\n \\\"MIR767_3P\\\",\\n \\\"ZNF549_TARGET_GENES\\\",\\n \\\"CACGTG_MYC_Q2\\\",\\n \\\"MIR6511A_5P\\\",\\n \\\"MIR12136\\\",\\n \\\"MIR3919\\\",\\n \\\"MIR3679_3P\\\",\\n \\\"MIR93_3P\\\",\\n \\\"MIR4272\\\",\\n \\\"MIR6731_5P\\\",\\n \\\"MIR208B_5P\\\",\\n \\\"MIR6792_5P\\\"\\n ],\\n \\\"C4\\\": [\\n \\\"GCM_UBE2N\\\",\\n \\\"MORF_PPP2R5E\\\",\\n \\\"MORF_BECN1\\\",\\n \\\"MORF_PRKAG1\\\",\\n \\\"MORF_RAB1A\\\",\\n \\\"MORF_UBE2A\\\",\\n \\\"MORF_TERF2IP\\\",\\n \\\"MORF_DDB1\\\",\\n \\\"MORF_SS18\\\",\\n \\\"MORF_TPR\\\",\\n \\\"GCM_MAX\\\",\\n \\\"GCM_DFFA\\\",\\n \\\"GCM_ZNF198\\\",\\n \\\"MORF_RAB11A\\\"\\n ],\\n \\\"C6\\\": [\\n \\\"SNF5_DN.V1_UP\\\"\\n ],\\n \\\"C7\\\": [\\n \\\"GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP\\\",\\n \\\"GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN\\\",\\n \\\"GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN\\\",\\n \\\"GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN\\\",\\n \\\"GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP\\\",\\n \\\"GSE36009_UNSTIM_VS_LPS_STIM_DC_DN\\\",\\n \\\"GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN\\\",\\n \\\"GSE339_CD4POS_VS_CD8POS_DC_DN\\\",\\n \\\"GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN\\\",\\n \\\"GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP\\\",\\n \\\"GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP\\\",\\n \\\"GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP\\\",\\n \\\"GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN\\\",\\n \\\"GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN\\\",\\n \\\"NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP\\\",\\n \\\"GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP\\\",\\n \\\"GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP\\\",\\n \\\"GSE27786_LIN_NEG_VS_CD4_TCELL_DN\\\",\\n \\\"GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN\\\",\\n \\\"GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN\\\",\\n \\\"GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN\\\",\\n \\\"GSE17721_LPS_VS_CPG_6H_BMDC_UP\\\",\\n \\\"NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP\\\",\\n \\\"GSE22886_IL2_VS_IL15_STIM_NKCELL_DN\\\",\\n \\\"GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN\\\",\\n \\\"GSE17721_12H_VS_24H_POLYIC_BMDC_UP\\\",\\n \\\"GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN\\\",\\n \\\"GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP\\\",\\n \\\"GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN\\\",\\n \\\"GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP\\\",\\n \\\"GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN\\\",\\n \\\"GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN\\\",\\n \\\"GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP\\\",\\n \\\"GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP\\\",\\n \\\"GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP\\\",\\n \\\"GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP\\\",\\n \\\"GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN\\\",\\n \\\"GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN\\\",\\n \\\"GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP\\\",\\n \\\"GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP\\\",\\n \\\"GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN\\\",\\n \\\"GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN\\\",\\n \\\"GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN\\\",\\n \\\"GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN\\\",\\n \\\"GSE17721_12H_VS_24H_CPG_BMDC_UP\\\",\\n \\\"GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN\\\",\\n \\\"GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN\\\",\\n \\\"GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP\\\",\\n \\\"GSE11818_WT_VS_DICER_KO_TREG_DN\\\",\\n \\\"GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP\\\",\\n \\\"GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP\\\",\\n \\\"GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP\\\",\\n \\\"GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP\\\",\\n \\\"GSE17721_POLYIC_VS_CPG_4H_BMDC_DN\\\",\\n \\\"GSE22886_TH1_VS_TH2_48H_ACT_DN\\\",\\n \\\"GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN\\\",\\n \\\"GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP\\\",\\n \\\"GSE27786_NKTCELL_VS_MONO_MAC_DN\\\",\\n \\\"GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN\\\",\\n \\\"GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN\\\",\\n \\\"GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN\\\",\\n \\\"GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP\\\",\\n \\\"GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN\\\",\\n \\\"GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP\\\",\\n \\\"GSE17721_LPS_VS_CPG_24H_BMDC_DN\\\",\\n \\\"GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP\\\"\\n ],\\n \\\"C8\\\": []\\n }\\n },\\n \\\"omim\\\": {\\n \\\"phenotype_annotations\\\": []\\n },\\n \\\"disgenet\\\": {\\n \\\"disease_annotations\\\": []\\n },\\n \\\"open_targets\\\": {\\n \\\"disease_annotations\\\": [\\n \\\"Overgrowth\\\",\\n \\\"Abnormality of the cardiovascular system\\\",\\n \\\"Mitral valve prolapse\\\",\\n \\\"Congestive heart failure\\\",\\n \\\"Patent ductus arteriosus\\\",\\n \\\"Dilated cardiomyopathy\\\",\\n \\\"Bicuspid aortic valve\\\",\\n \\\"Myocardial fibrosis\\\",\\n \\\"Increased total eosinophil count\\\",\\n \\\"Thrombocytosis\\\",\\n \\\"Anemia\\\",\\n \\\"Acute kidney injury\\\",\\n \\\"Glucose intolerance\\\",\\n \\\"Pulmonary hypoplasia\\\",\\n \\\"Pneumonia\\\",\\n \\\"Asthma\\\",\\n \\\"Ischemic stroke\\\",\\n \\\"Cerebral ischemia\\\",\\n \\\"Vascular dilatation\\\",\\n \\\"Aortic dissection\\\",\\n \\\"Systemic lupus erythematosus\\\",\\n \\\"Autoimmunity\\\",\\n \\\"Hyperglycemia\\\",\\n \\\"Hyperlipidemia\\\",\\n \\\"Hypercholesterolemia\\\",\\n \\\"Skeletal muscle atrophy\\\",\\n \\\"Muscular dystrophy\\\",\\n \\\"Cachexia\\\",\\n \\\"Thrombophlebitis\\\",\\n \\\"Miscarriage\\\",\\n \\\"Ureteral obstruction\\\",\\n \\\"Airway obstruction\\\",\\n \\\"Amyotrophic lateral sclerosis\\\",\\n \\\"Peripheral demyelination\\\",\\n \\\"Inflammatory abnormality of the skin\\\",\\n \\\"Arrhythmia\\\",\\n \\\"Myelofibrosis\\\",\\n \\\"Hepatitis\\\",\\n \\\"Reduced sperm motility\\\",\\n \\\"Urethral stricture\\\",\\n \\\"Renal atrophy\\\",\\n \\\"Cervical polyp\\\",\\n \\\"Shock\\\",\\n \\\"Granuloma\\\",\\n \\\"Chronic colitis\\\",\\n \\\"Neoplasm of the lung\\\",\\n \\\"Cognitive impairment\\\",\\n \\\"Sepsis\\\",\\n \\\"geleophysic dysplasia\\\",\\n \\\"colorectal adenoma\\\",\\n \\\"airway hyperresponsiveness\\\",\\n \\\"skin aging\\\",\\n \\\"triple-negative breast cancer\\\",\\n \\\"bile duct carcinoma\\\",\\n \\\"glioma\\\",\\n \\\"hydronephrosis\\\",\\n \\\"rectal adenocarcinoma\\\",\\n \\\"intracerebral hemorrhage\\\",\\n \\\"renal cell adenocarcinoma\\\",\\n \\\"Autoimmune Hepatitis\\\",\\n \\\"neurodegenerative disease\\\",\\n \\\"brain disease\\\",\\n \\\"aortic disease\\\",\\n \\\"allergic rhinitis\\\",\\n \\\"esophageal squamous cell carcinoma\\\",\\n \\\"head and neck neoplasia\\\",\\n \\\"breast ductal adenocarcinoma\\\",\\n \\\"laryngeal squamous cell carcinoma\\\",\\n \\\"ovarian adenocarcinoma\\\",\\n \\\"ovarian mucinous adenocarcinoma\\\",\\n \\\"ovarian teratoma\\\",\\n \\\"bladder transitional cell carcinoma\\\",\\n \\\"brain glioblastoma\\\",\\n \\\"dysplastic oral keratinocyte\\\",\\n \\\"undifferentiated carcinoma\\\",\\n \\\"cerebral amyloid angiopathy\\\",\\n \\\"head and neck malignant neoplasia\\\",\\n \\\"breastfeeding duration\\\",\\n \\\"urgency urinary incontinence\\\",\\n \\\"fibrosis\\\",\\n \\\"Balkan nephropathy\\\",\\n \\\"congenital rubella\\\",\\n \\\"echinococcosis\\\",\\n \\\"Gerstmann syndrome\\\",\\n \\\"inclusion body myositis\\\",\\n \\\"muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10\\\",\\n \\\"severe neurodegenerative syndrome with lipodystrophy\\\",\\n \\\"Diamond-Blackfan anemia\\\",\\n \\\"cardiofaciocutaneous syndrome\\\",\\n \\\"adrenomyeloneuropathy\\\",\\n \\\"hereditary sensory and autonomic neuropathy\\\",\\n \\\"nasopharyngeal carcinoma\\\",\\n \\\"keratoconus\\\",\\n \\\"dentin dysplasia\\\",\\n \\\"T-cell non-Hodgkin lymphoma\\\",\\n \\\"dyskeratosis congenita\\\",\\n \\\"pneumoconiosis\\\",\\n \\\"early myoclonic encephalopathy\\\",\\n \\\"laryngotracheoesophageal cleft\\\",\\n \\\"cleft palate\\\",\\n \\\"cryopyrin-associated periodic syndrome\\\",\\n \\\"holoprosencephaly\\\",\\n \\\"pachyonychia congenita\\\",\\n \\\"familial rhabdoid tumor\\\",\\n \\\"familial hyperaldosteronism\\\",\\n \\\"primary ciliary dyskinesia\\\",\\n \\\"meningioma\\\",\\n \\\"pilocytic astrocytoma\\\",\\n \\\"hemangioblastoma\\\",\\n \\\"microcephaly-brain defect-spasticity-hypernatremia syndrome\\\",\\n \\\"thanatophoric dysplasia\\\",\\n \\\"idiopathic pulmonary arterial hypertension\\\",\\n \\\"heritable pulmonary arterial hypertension\\\",\\n \\\"juvenile polyposis syndrome\\\",\\n \\\"congenital herpes simplex virus infection\\\",\\n \\\"popliteal pterygium syndrome\\\",\\n \\\"ameloblastoma\\\",\\n \\\"hypersensitivity pneumonitis\\\",\\n \\\"persistent truncus arteriosus\\\",\\n \\\"colorectal adenocarcinoma\\\",\\n \\\"Crohn's disease\\\",\\n \\\"cutaneous melanoma\\\",\\n \\\"diabetes mellitus\\\",\\n \\\"diabetic nephropathy\\\",\\n \\\"diffuse gastric adenocarcinoma\\\",\\n \\\"diffuse large B-cell lymphoma\\\",\\n \\\"breast ductal carcinoma in situ\\\",\\n \\\"emphysema\\\",\\n \\\"epilepsy\\\",\\n \\\"esophageal adenocarcinoma\\\",\\n \\\"fetal growth restriction\\\",\\n \\\"follicular thyroid adenoma\\\",\\n \\\"ganglioneuroma\\\",\\n \\\"follicular thyroid carcinoma\\\",\\n \\\"gastric adenocarcinoma\\\",\\n \\\"gastric intestinal type adenocarcinoma\\\",\\n \\\"genetic disorder\\\",\\n \\\"germ cell tumor\\\",\\n \\\"glioblastoma multiforme\\\",\\n \\\"hypertrophic cardiomyopathy\\\",\\n \\\"immune system disease\\\",\\n \\\"infection\\\",\\n \\\"infertility\\\",\\n \\\"injury\\\",\\n \\\"insulinoma\\\",\\n \\\"intracranial hemorrhage\\\",\\n \\\"ischemia\\\",\\n \\\"large cell neuroendocrine carcinoma\\\",\\n \\\"leukemia\\\",\\n \\\"lung adenocarcinoma\\\",\\n \\\"lymphoma\\\",\\n \\\"mesothelioma\\\",\\n \\\"metabolic disease\\\",\\n \\\"myocardial infarction\\\",\\n \\\"neoplasm\\\",\\n \\\"nervous system disease\\\",\\n \\\"neuroblastoma\\\",\\n \\\"oligodendroglioma\\\",\\n \\\"osteosarcoma\\\",\\n \\\"neural tube defect\\\",\\n \\\"tuberculosis\\\",\\n \\\"glioblastoma\\\",\\n \\\"carcinoma of liver and intrahepatic biliary tract\\\",\\n \\\"hereditary nonpolyposis colon cancer\\\",\\n \\\"Zika virus infectious disease\\\",\\n \\\"left ventricular noncompaction\\\",\\n \\\"multiminicore myopathy\\\",\\n \\\"Loeys-Dietz syndrome\\\",\\n \\\"neurofibromatosis type 1\\\",\\n \\\"Leber congenital amaurosis\\\",\\n \\\"osteogenesis imperfecta\\\",\\n \\\"progressive supranuclear palsy\\\",\\n \\\"intrahepatic cholestasis\\\",\\n \\\"lymphedema\\\",\\n \\\"posterior cortical atrophy\\\",\\n \\\"follicular lymphoma\\\",\\n \\\"kidney Wilms tumor\\\",\\n \\\"bronchopulmonary dysplasia\\\",\\n \\\"sarcoidosis\\\",\\n \\\"peeling skin syndrome\\\",\\n \\\"lissencephaly with cerebellar hypoplasia\\\",\\n \\\"aggressive NK-cell leukemia\\\",\\n \\\"adult T-cell leukemia/lymphoma\\\",\\n \\\"extranodal nasal NK/T cell lymphoma\\\",\\n \\\"Turner syndrome\\\",\\n \\\"familial thoracic aortic aneurysm and aortic dissection\\\",\\n \\\"Ehlers-Danlos syndrome\\\",\\n \\\"muscular dystrophy\\\",\\n \\\"precursor B-cell acute lymphoblastic leukemia\\\",\\n \\\"superficial spreading melanoma\\\",\\n \\\"lung neoplasm\\\",\\n \\\"intestinal neoplasm\\\",\\n \\\"odontogenic neoplasm\\\",\\n \\\"disorder of ear\\\",\\n \\\"endometrium neoplasm\\\",\\n \\\"prostate neoplasm\\\",\\n \\\"mucoepidermoid carcinoma of parotid gland\\\",\\n \\\"carcinoma of pharynx\\\",\\n \\\"polyp of colon\\\",\\n \\\"low grade glioma\\\",\\n \\\"corticobasal degeneration disorder\\\",\\n \\\"cervical intraepithelial neoplasia\\\",\\n \\\"viral myocarditis\\\",\\n \\\"lip and oral cavity carcinoma\\\",\\n \\\"corneal infection\\\",\\n \\\"pseudoxanthoma elasticum (inherited or acquired)\\\",\\n \\\"chondrogenic neoplasm\\\",\\n \\\"intraepithelial neoplasia\\\",\\n \\\"squamous cell intraepithelial neoplasia\\\",\\n \\\"liver and intrahepatic bile duct neoplasm\\\",\\n \\\"hypertensive nephropathy\\\",\\n \\\"myocardial disorder\\\",\\n \\\"tubular adenoma\\\",\\n \\\"pulmonary sarcoidosis\\\",\\n \\\"gonorrhea\\\",\\n \\\"B-cell acute lymphoblastic leukemia\\\",\\n \\\"chronic lymphocytic leukemia\\\",\\n \\\"gastric carcinoma\\\",\\n \\\"head and neck squamous cell carcinoma\\\",\\n \\\"hepatocellular carcinoma\\\",\\n \\\"Hodgkins lymphoma\\\",\\n \\\"invasive breast ductal carcinoma\\\",\\n \\\"metabolic syndrome\\\",\\n \\\"myelodysplastic syndrome\\\",\\n \\\"oral squamous cell carcinoma\\\",\\n \\\"gastritis\\\",\\n \\\"acute lymphoblastic leukemia\\\",\\n \\\"acute myeloid leukemia\\\",\\n \\\"acute promyelocytic leukemia\\\",\\n \\\"adenocarcinoma\\\",\\n \\\"adenoma\\\",\\n \\\"age\\\",\\n \\\"aortic stenosis\\\",\\n \\\"astrocytoma\\\",\\n \\\"atopic eczema\\\",\\n \\\"atrial fibrillation\\\",\\n \\\"Barrett's esophagus\\\",\\n \\\"benign prostatic hyperplasia\\\",\\n \\\"bladder tumor\\\",\\n \\\"breast adenocarcinoma\\\",\\n \\\"breast carcinoma\\\",\\n \\\"bronchoalveolar adenocarcinoma\\\",\\n \\\"carcinoma\\\",\\n \\\"cardiomyopathy\\\",\\n \\\"cardiovascular disease\\\",\\n \\\"central nervous system cancer\\\",\\n \\\"chondrosarcoma\\\",\\n \\\"chromophobe renal cell carcinoma\\\",\\n \\\"chronic myelogenous leukemia\\\",\\n \\\"chronic obstructive pulmonary disease\\\",\\n \\\"clear cell renal carcinoma\\\",\\n \\\"endometrial carcinoma\\\",\\n \\\"ovarian serous carcinoma\\\",\\n \\\"renal fibrosis\\\",\\n \\\"Abruptio Placentae\\\",\\n \\\"Adenomyosis\\\",\\n \\\"Carcinoma, Lewis Lung\\\",\\n \\\"chronic myelomonocytic leukemia\\\",\\n \\\"Marchiafava-Bignami Disease\\\",\\n \\\"oral submucous fibrosis\\\",\\n \\\"osteoradionecrosis\\\",\\n \\\"renal nutcracker syndrome\\\",\\n \\\"amyloidosis\\\",\\n \\\"mucositis\\\",\\n \\\"neuroendocrine neoplasm\\\",\\n \\\"neuromuscular disease\\\",\\n \\\"oral mucositis\\\",\\n \\\"Spinal cord injury\\\",\\n \\\"cutaneous squamous cell carcinoma\\\",\\n \\\"Barrett adenocarcinoma\\\",\\n \\\"colon adenocarcinoma\\\",\\n \\\"colon carcinoma\\\",\\n \\\"colorectal carcinoma\\\",\\n \\\"pharyngeal squamous cell carcinoma\\\",\\n \\\"soft tissue sarcoma\\\",\\n \\\"undifferentiated pleomorphic sarcoma\\\",\\n \\\"connective tissue disease\\\",\\n \\\"pneumonitis\\\",\\n \\\"intrahepatic cholangiocarcinoma\\\",\\n \\\"chronic rhinosinusitis with nasal polyps\\\",\\n \\\"chronic rhinosinusitis without nasal polyps\\\",\\n \\\"glomerular disease\\\",\\n \\\"nephritis\\\",\\n \\\"Neurogenic bladder\\\",\\n \\\"Glomerular sclerosis\\\",\\n \\\"Glomerulonephritis\\\",\\n \\\"Nephropathy\\\",\\n \\\"Uterine leiomyoma\\\",\\n \\\"Cleft palate\\\",\\n \\\"Hydrocephalus\\\",\\n \\\"Cataract\\\",\\n \\\"Myopia\\\",\\n \\\"Autism\\\",\\n \\\"Infertility\\\",\\n \\\"Diabetes mellitus\\\",\\n \\\"Insulin resistance\\\",\\n \\\"Osteoporosis\\\",\\n \\\"Hyperkeratosis\\\",\\n \\\"Intellectual disability\\\",\\n \\\"Ataxia\\\",\\n \\\"Mental deterioration\\\",\\n \\\"Stroke\\\",\\n \\\"Rheumatoid arthritis\\\",\\n \\\"Cirrhosis\\\",\\n \\\"Hepatic fibrosis\\\",\\n \\\"Hepatic steatosis\\\",\\n \\\"Obesity\\\",\\n \\\"mixed connective tissue disease\\\",\\n \\\"pneumocystosis\\\",\\n \\\"pseudomyxoma peritonei\\\",\\n \\\"silicosis\\\",\\n \\\"toxoplasmosis\\\",\\n \\\"hemoglobin A1 measurement\\\",\\n \\\"BMI-adjusted waist-hip ratio\\\",\\n \\\"liver dysplastic nodule\\\",\\n \\\"gut microbiome measurement\\\",\\n \\\"platelet crit\\\",\\n \\\"allergen exposure measurement\\\",\\n \\\"calf circumference measurement\\\",\\n \\\"dysplasia\\\",\\n \\\"lobular breast carcinoma\\\",\\n \\\"nodular melanoma\\\",\\n \\\"non-functioning pituitary adenoma\\\",\\n \\\"status epilepticus\\\",\\n \\\"steatosis\\\",\\n \\\"urothelial carcinoma\\\",\\n \\\"digestive system neoplasm\\\",\\n \\\"Hepatobiliary Neoplasm\\\",\\n \\\"American trypanosomiasis\\\",\\n \\\"acute myocardial infarction\\\",\\n \\\"pemphigus foliaceus\\\",\\n \\\"cystic kidney disease\\\",\\n \\\"Polycystic Kidney Disease\\\",\\n \\\"arteriosclerosis\\\",\\n \\\"hyperuricemia\\\",\\n \\\"skin carcinoma\\\",\\n \\\"heel bone mineral density\\\",\\n \\\"pulmonary fibrosis\\\",\\n \\\"hyperaldosteronism\\\",\\n \\\"gastric ulcer\\\",\\n \\\"infarction\\\",\\n \\\"aortic valve disease\\\",\\n \\\"heart valve disease\\\",\\n \\\"mitral valve disease\\\",\\n \\\"urinary tract obstruction\\\",\\n \\\"prostate disease\\\",\\n \\\"stomach disease\\\",\\n \\\"myocarditis\\\",\\n \\\"aneurysm\\\",\\n \\\"enthesopathy\\\",\\n \\\"musculoskeletal system disease\\\",\\n \\\"metastasis\\\",\\n \\\"Gallbladder Adenocarcinoma\\\",\\n \\\"Granular Cell Tumor\\\",\\n \\\"Hepatoblastoma\\\",\\n \\\"HER2 Positive Breast Carcinoma\\\",\\n \\\"Invasive Breast Carcinoma\\\",\\n \\\"Malignant Mesothelioma\\\",\\n \\\"Malignant Pancreatic Neoplasm\\\",\\n \\\"Medullomyoblastoma with Myogenic Differentiation\\\",\\n \\\"Microcystic Meningioma\\\",\\n \\\"Mixed Tumor of the Salivary Gland\\\",\\n \\\"Nasal Cavity Polyp\\\",\\n \\\"Osteoblastoma\\\",\\n \\\"Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation\\\",\\n \\\"Ovarian Endometriosis\\\",\\n \\\"Paraganglioma\\\",\\n \\\"Placental Choriocarcinoma\\\",\\n \\\"Rectal Tubular Adenoma\\\",\\n \\\"Sarcomatoid Carcinoma\\\",\\n \\\"Signet Ring Cell Gastric Adenocarcinoma\\\",\\n \\\"Synovial Chondromatosis\\\",\\n \\\"Testicular Non-Seminomatous Germ Cell Tumor\\\",\\n \\\"Testicular Yolk Sac Tumor\\\",\\n \\\"Thyroid Gland Undifferentiated (Anaplastic) Carcinoma\\\",\\n \\\"Uterine Carcinosarcoma\\\",\\n \\\"Vulvar Squamous Cell Carcinoma\\\",\\n \\\"acute respiratory distress syndrome\\\",\\n \\\"sarcopenia\\\",\\n \\\"rectum cancer\\\",\\n \\\"acanthosis nigricans\\\",\\n \\\"mucous membrane pemphigoid\\\",\\n \\\"punctate palmoplantar keratoderma type III\\\",\\n \\\"adrenal cortex carcinoma\\\",\\n \\\"alcoholic liver cirrhosis\\\",\\n \\\"atrophic gastritis\\\",\\n \\\"dental fluorosis\\\",\\n \\\"dry eye syndrome\\\",\\n \\\"Helicobacter pylori infectious disease\\\",\\n \\\"inflammatory breast carcinoma\\\",\\n \\\"multiple system atrophy\\\",\\n \\\"myeloid sarcoma\\\",\\n \\\"nodular goiter\\\",\\n \\\"periapical granuloma\\\",\\n \\\"pulmonary edema\\\",\\n \\\"renovascular hypertension\\\",\\n \\\"retinopathy of prematurity\\\",\\n \\\"rheumatic heart disease\\\",\\n \\\"thromboangiitis obliterans\\\",\\n \\\"tooth disease\\\",\\n \\\"uremia\\\",\\n \\\"non-alcoholic steatohepatitis\\\",\\n \\\"Cryptogenic Organizing Pneumonia\\\",\\n \\\"Fascioliasis\\\",\\n \\\"Follicular Cyst\\\",\\n \\\"Heavy Chain Disease\\\",\\n \\\"Hepatopulmonary Syndrome\\\",\\n \\\"Myocardial Ischemia\\\",\\n \\\"Pelvic Inflammatory Disease\\\",\\n \\\"Periapical Periodontitis\\\",\\n \\\"Peritoneal Fibrosis\\\",\\n \\\"Pneumonia, Aspiration\\\",\\n \\\"Respiratory Syncytial Virus Infection\\\",\\n \\\"diabetic cardiomyopathy\\\",\\n \\\"diabetic foot\\\",\\n \\\"endothelial dysfunction\\\",\\n \\\"Mantle cell lymphoma\\\",\\n \\\"Merkel cell skin cancer\\\",\\n \\\"schistosomiasis\\\",\\n \\\"abortion\\\",\\n \\\"Autosomal dominant polycystic kidney disease\\\",\\n \\\"osteoporosis-pseudoglioma syndrome\\\",\\n \\\"Bartsocas-Papas syndrome 1\\\",\\n \\\"congenital bilateral aplasia of vas deferens from CFTR mutation\\\",\\n \\\"SHOX-related short stature\\\",\\n \\\"intellectual disability, X-linked syndromic, Turner type\\\",\\n \\\"Fabry disease\\\",\\n \\\"X-linked corneal dermoid\\\",\\n \\\"Aarskog-Scott syndrome, X-linked\\\",\\n \\\"holoprosencephaly-hypokinesia-congenital contractures syndrome\\\",\\n \\\"Melnick-Needles syndrome\\\",\\n \\\"Duchenne muscular dystrophy\\\",\\n \\\"X-linked retinoschisis\\\",\\n \\\"Wilson disease\\\",\\n \\\"adenomyosis\\\",\\n \\\"Timothy syndrome\\\",\\n \\\"supranuclear palsy, progressive, 1\\\",\\n \\\"Ehlers-Danlos syndrome, musculocontractural type\\\",\\n \\\"tetrasomy 12p\\\",\\n \\\"sickle cell anemia\\\",\\n \\\"hypotonia-cystinuria syndrome\\\",\\n \\\"lymphangioleiomyomatosis\\\",\\n \\\"gastrointestinal stromal tumor\\\",\\n \\\"autoimmune lymphoproliferative syndrome type 2B\\\",\\n \\\"endometrial cancer\\\",\\n \\\"Loeys-Dietz syndrome 1\\\",\\n \\\"hyperinsulinemic hypoglycemia, familial, 4\\\",\\n \\\"preterm premature rupture of the membranes\\\",\\n \\\"Mungan syndrome\\\",\\n \\\"Crouzon syndrome-acanthosis nigricans syndrome\\\",\\n \\\"papillary renal cell carcinoma\\\",\\n \\\"papillary thyroid carcinoma\\\",\\n \\\"periodontitis\\\",\\n \\\"polycystic ovary syndrome\\\",\\n \\\"preeclampsia\\\",\\n \\\"prostate adenocarcinoma\\\",\\n \\\"psoriasis\\\",\\n \\\"pterygium\\\",\\n \\\"renal cell carcinoma\\\",\\n \\\"rheumatoid arthritis\\\",\\n \\\"sarcoma\\\",\\n \\\"severe acute respiratory syndrome\\\",\\n \\\"small cell lung carcinoma\\\",\\n \\\"squamous cell carcinoma\\\",\\n \\\"squamous cell lung carcinoma\\\",\\n \\\"spondyloarthropathy\\\",\\n \\\"stroke\\\",\\n \\\"subarachnoid hemorrhage\\\",\\n \\\"systemic scleroderma\\\",\\n \\\"ulcerative colitis\\\",\\n \\\"melanoma\\\",\\n \\\"hepatocellular adenoma\\\",\\n \\\"viral disease\\\",\\n \\\"HIV infection\\\",\\n \\\"idiopathic pulmonary fibrosis\\\",\\n \\\"malignant pleural mesothelioma\\\",\\n \\\"bacterial disease\\\",\\n \\\"pneumococcal infection\\\",\\n \\\"temporal lobe epilepsy\\\",\\n \\\"celiac disease\\\",\\n \\\"cervical carcinoma\\\",\\n \\\"cytomegalovirus infection\\\",\\n \\\"endometriosis\\\",\\n \\\"experimental autoimmune encephalomyelitis\\\",\\n \\\"parasitic infection\\\",\\n \\\"malaria\\\",\\n \\\"folate deficiency\\\",\\n \\\"lung carcinoma\\\",\\n \\\"ovarian carcinoma\\\",\\n \\\"familial amyotrophic lateral sclerosis\\\",\\n \\\"pulmonary arterial hypertension\\\",\\n \\\"age-related macular degeneration\\\",\\n \\\"synovial sarcoma\\\",\\n \\\"cerebral creatine deficiency syndrome\\\",\\n \\\"arterial disorder\\\",\\n \\\"glomerulosclerosis\\\",\\n \\\"villous adenoma\\\",\\n \\\"mucosal melanoma\\\",\\n \\\"ovarian clear cell cancer\\\",\\n \\\"central nervous system primitive neuroectodermal neoplasm\\\",\\n \\\"Crohn ileitis\\\",\\n \\\"vertebral column disorder\\\",\\n \\\"endometrial disorder\\\",\\n \\\"gastric cancer\\\",\\n \\\"penile cancer\\\",\\n \\\"myopia\\\",\\n \\\"pulmonary alveolar proteinosis\\\",\\n \\\"Chagas disease\\\",\\n \\\"leiomyoma\\\",\\n \\\"brain cancer\\\",\\n \\\"tuberous sclerosis\\\",\\n \\\"sick sinus syndrome\\\",\\n \\\"arteriovenous hemangioma/malformation\\\",\\n \\\"hypertensive heart disease\\\",\\n \\\"head and neck carcinoma\\\",\\n \\\"depressive disorder\\\",\\n \\\"pneumothorax\\\",\\n \\\"Richter syndrome\\\",\\n \\\"peritoneum cancer\\\",\\n \\\"thyroid cancer\\\",\\n \\\"disorder of sexual differentiation\\\",\\n \\\"vulvar melanoma\\\",\\n \\\"papilloma\\\",\\n \\\"rectosigmoid junction neoplasm\\\",\\n \\\"Treacher-Collins syndrome\\\",\\n \\\"prostatic acinar adenocarcinoma\\\",\\n \\\"gingival overgrowth\\\",\\n \\\"inherited lipid metabolism disorder\\\",\\n \\\"skin squamous cell carcinoma\\\",\\n \\\"teratoma\\\",\\n \\\"bone inflammation disease\\\",\\n \\\"extraosseous osteosarcoma\\\",\\n \\\"chondroblastic osteosarcoma\\\",\\n \\\"cerebral infarction\\\",\\n \\\"liver cancer\\\",\\n \\\"uterine cancer\\\",\\n \\\"lung benign neoplasm\\\",\\n \\\"skin cancer\\\",\\n \\\"cervical cancer\\\",\\n \\\"seminoma\\\",\\n \\\"breast angiosarcoma\\\",\\n \\\"cerebellar pilocytic astrocytoma\\\",\\n \\\"salivary gland adenoid cystic carcinoma\\\",\\n \\\"bile duct adenocarcinoma\\\",\\n \\\"gastroesophageal junction adenocarcinoma\\\",\\n \\\"thoracic cancer\\\",\\n \\\"acral lentiginous melanoma\\\",\\n \\\"endometrial mixed adenocarcinoma\\\",\\n \\\"female breast carcinoma\\\",\\n \\\"inflammation\\\",\\n \\\"erythrocyte volume\\\",\\n \\\"glomerular filtration rate\\\",\\n \\\"bone tissue density\\\",\\n \\\"progesterone amount\\\",\\n \\\"serum alanine aminotransferase amount\\\",\\n \\\"serum urea amount\\\",\\n \\\"serum creatinine amount\\\",\\n \\\"body height\\\",\\n \\\"cyst\\\",\\n \\\"Hypotonia - cystinuria syndrome\\\",\\n \\\"Ch\\\\u00e9diak-Higashi syndrome\\\",\\n \\\"\\\\u00c5land Islands eye disease\\\",\\n \\\"Hydrocephalus with stenosis of the aqueduct of Sylvius\\\",\\n \\\"Autoimmune lymphoproliferative syndrome with recurrent viral infections\\\",\\n \\\"Rare disease with thoracic aortic aneurysm and aortic dissection\\\",\\n \\\"Persistent M\\\\u00fcllerian duct syndrome\\\",\\n \\\"WHIM syndrome\\\",\\n \\\"Familial adenomatous polyposis\\\",\\n \\\"Other metabolic disease\\\",\\n \\\"hematocrit\\\",\\n \\\"C-reactive protein measurement\\\",\\n \\\"hematological measurement\\\",\\n \\\"alkaline phosphatase measurement\\\",\\n \\\"cryptorchidism\\\",\\n \\\"lymphocyte count\\\",\\n \\\"gestational diabetes\\\",\\n \\\"acute lung injury\\\",\\n \\\"serum gamma-glutamyl transferase measurement\\\",\\n \\\"HbA1c measurement\\\",\\n \\\"high density lipoprotein cholesterol measurement\\\",\\n \\\"osteoarthritis, knee\\\",\\n \\\"wet macular degeneration\\\",\\n \\\"insomnia\\\",\\n \\\"hypothyroidism\\\",\\n \\\"pelvic organ prolapse\\\",\\n \\\"metabolite measurement\\\",\\n \\\"eosinophil count\\\",\\n \\\"lymph node metastatic carcinoma\\\",\\n \\\"embryonal carcinoma\\\",\\n \\\"lumbar disc degeneration\\\",\\n \\\"lean body mass\\\",\\n \\\"type 2 diabetes nephropathy\\\",\\n \\\"monocyte count\\\",\\n \\\"autoimmune disease\\\",\\n \\\"congenital heart disease\\\",\\n \\\"cholangiocarcinoma\\\",\\n \\\"human african trypanosomiasis\\\",\\n \\\"reading\\\",\\n \\\"congenital heart malformation\\\",\\n \\\"temporomandibular joint disorder\\\",\\n \\\"axial length measurement\\\",\\n \\\"myeloid leukemia\\\",\\n \\\"lupus erythematosus\\\",\\n \\\"allergic asthma\\\",\\n \\\"fatty liver disease\\\",\\n \\\"Alzheimer disease\\\",\\n \\\"asthma\\\",\\n \\\"urinary bladder carcinoma\\\",\\n \\\"cancer\\\",\\n \\\"glaucoma\\\",\\n \\\"schizophrenia\\\",\\n \\\"cataract\\\",\\n \\\"type 1 diabetes mellitus\\\",\\n \\\"type 2 diabetes mellitus\\\",\\n \\\"pulmonary hypertension\\\",\\n \\\"osteoarthritis\\\",\\n \\\"pancreatic ductal adenocarcinoma\\\",\\n \\\"bacterial urinary tract infection\\\",\\n \\\"multiple sclerosis\\\",\\n \\\"skin basal cell carcinoma\\\",\\n \\\"brain glioma\\\",\\n \\\"colorectal cancer\\\",\\n \\\"Wilms tumor\\\",\\n \\\"Townes-Brocks syndrome\\\",\\n \\\"nevoid basal cell carcinoma syndrome\\\",\\n \\\"breast cancer\\\",\\n \\\"congenital contractural arachnodactyly\\\",\\n \\\"Duane retraction syndrome\\\",\\n \\\"dyschromatosis symmetrica hereditaria\\\",\\n \\\"metastatic malignant neoplasm\\\",\\n \\\"Loeys-Dietz syndrome 6\\\",\\n \\\"cervical squamous intraepithelial neoplasia\\\",\\n \\\"leukoplakia\\\",\\n \\\"spinal cord injury\\\",\\n \\\"ulcer disease\\\",\\n \\\"desmoplastic melanoma\\\",\\n \\\"myelofibrosis\\\",\\n \\\"oral cavity carcinoma\\\",\\n \\\"rectal carcinoma\\\",\\n \\\"hydrocephalus, congenital, 3, with brain anomalies\\\",\\n \\\"nasal cavity and paranasal sinus carcinoma\\\",\\n \\\"COVID-19\\\",\\n \\\"Dravet syndrome\\\",\\n \\\"COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults\\\",\\n \\\"disease arising from reactivation of latent virus\\\",\\n \\\"Friedreich ataxia\\\",\\n \\\"malignant glioma\\\",\\n \\\"achalasia-alacrima syndrome\\\",\\n \\\"metabolic bone disorder\\\",\\n \\\"congenital heart defects, multiple types, 8, with or without heterotaxy\\\",\\n \\\"postmenopausal osteoporosis\\\",\\n \\\"intestinal polyp\\\",\\n \\\"dissection\\\",\\n \\\"uterine neoplasm\\\",\\n \\\"pancreatic neoplasm\\\",\\n \\\"kidney neoplasm\\\",\\n \\\"breast neoplasm\\\",\\n \\\"brain aneurysm\\\",\\n \\\"colitis\\\",\\n \\\"osteoporosis\\\",\\n \\\"chronic kidney disease\\\",\\n \\\"ovarian neoplasm\\\",\\n \\\"acne\\\",\\n \\\"stomach neoplasm\\\",\\n \\\"ankylosing spondylitis\\\",\\n \\\"ciliopathy\\\",\\n \\\"deep vein thrombosis\\\",\\n \\\"obstructive sleep apnea\\\",\\n \\\"necrotizing enterocolitis\\\",\\n \\\"relapsing-remitting multiple sclerosis\\\",\\n \\\"angiosarcoma\\\",\\n \\\"colorectal neoplasm\\\",\\n \\\"atherosclerosis\\\",\\n \\\"open-angle glaucoma\\\",\\n \\\"androgenetic alopecia\\\",\\n \\\"basal cell carcinoma\\\",\\n \\\"IGA glomerulonephritis\\\",\\n \\\"hepatitis B virus infection\\\",\\n \\\"skin neoplasm\\\",\\n \\\"Keloid\\\",\\n \\\"Abdominal Aortic Aneurysm\\\",\\n \\\"chronic hepatitis C virus infection\\\",\\n \\\"eosinophilic esophagitis\\\",\\n \\\"focal segmental glomerulosclerosis\\\",\\n \\\"interstitial lung disease\\\",\\n \\\"mucocutaneous lymph node syndrome\\\",\\n \\\"myeloproliferative disorder\\\",\\n \\\"nephrotic syndrome\\\",\\n \\\"vascular disease\\\",\\n \\\"thoracic aortic aneurysm\\\",\\n \\\"venous thromboembolism\\\",\\n \\\"platelet count\\\",\\n \\\"body mass index\\\",\\n \\\"neuroimaging measurement\\\",\\n \\\"metastatic neoplasm\\\",\\n \\\"whole body water mass\\\",\\n \\\"kidney injury\\\",\\n \\\"bone metastasis\\\",\\n \\\"gastrointestinal disease\\\",\\n \\\"aspartate aminotransferase to alanine aminotransferase ratio\\\",\\n \\\"urea measurement\\\",\\n \\\"viral load\\\",\\n \\\"2-hydroxyacetaminophen sulfate measurement\\\",\\n \\\"aging\\\",\\n \\\"serum lipopolysaccharide activity\\\",\\n \\\"cecum adenocarcinoma\\\",\\n \\\"chronic rhinosinusitis\\\",\\n \\\"cystitis\\\",\\n \\\"ependymoma\\\",\\n \\\"granulosa cell tumor\\\",\\n \\\"metaplastic breast carcinoma\\\",\\n \\\"ovarian clear cell adenocarcinoma\\\",\\n \\\"pancreatic adenocarcinoma\\\",\\n \\\"pancreatic neuroendocrine tumor\\\",\\n \\\"ACTH-Producing Pituitary Gland Adenoma\\\",\\n \\\"Adenomatoid Odontogenic Tumor\\\",\\n \\\"Ampulla of Vater Carcinoma\\\",\\n \\\"Anal Squamous Cell Carcinoma\\\",\\n \\\"Anaplastic (Malignant) Meningioma\\\",\\n \\\"Appendix Adenocarcinoma\\\",\\n \\\"Appendix Goblet Cell Carcinoid\\\",\\n \\\"Atrophy\\\",\\n \\\"Atypical Meningioma\\\",\\n \\\"Bladder Small Cell Neuroendocrine Carcinoma\\\",\\n \\\"Breast Carcinoma by Gene Expression Profile\\\",\\n \\\"cervical squamous cell carcinoma\\\",\\n \\\"Columnar Cell Hyperplasia of the Breast\\\",\\n \\\"Duodenal Adenocarcinoma\\\",\\n \\\"Endometrial Clear Cell Adenocarcinoma\\\",\\n \\\"Endometrial Endometrioid Adenocarcinoma\\\",\\n \\\"Extramammary Paget Disease\\\",\\n \\\"fibrodysplasia ossificans progressiva\\\",\\n \\\"hereditary diffuse gastric adenocarcinoma\\\",\\n \\\"Holt-Oram syndrome\\\",\\n \\\"Huntington disease\\\",\\n \\\"Pallister-Hall syndrome\\\",\\n \\\"Nager acrofacial dysostosis\\\",\\n \\\"Marfan syndrome\\\",\\n \\\"Cowden syndrome 1\\\",\\n \\\"nail-patella syndrome\\\",\\n \\\"ovarian cancer\\\",\\n \\\"Andersen-Tawil syndrome\\\",\\n \\\"polyostotic fibrous dysplasia\\\",\\n \\\"juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome\\\",\\n \\\"nonpapillary renal cell carcinoma\\\",\\n \\\"Mobius syndrome\\\",\\n \\\"Peyronie disease\\\",\\n \\\"prostate cancer\\\",\\n \\\"retinoblastoma\\\",\\n \\\"acrodermatitis enteropathica\\\",\\n \\\"mitochondrial DNA depletion syndrome 4a\\\",\\n \\\"Alstrom syndrome\\\",\\n \\\"anencephaly 1\\\",\\n \\\"microphthalmia with limb anomalies\\\",\\n \\\"Bloom syndrome\\\",\\n \\\"lung cancer\\\",\\n \\\"cerebrotendinous xanthomatosis\\\",\\n \\\"cystic fibrosis\\\",\\n \\\"recessive dystrophic epidermolysis bullosa\\\",\\n \\\"Haim-Munk syndrome\\\",\\n \\\"Laurence-Moon syndrome\\\",\\n \\\"Nijmegen breakage syndrome\\\",\\n \\\"Miyoshi myopathy\\\",\\n \\\"Schwartz-Jampel syndrome\\\",\\n \\\"Leigh syndrome\\\",\\n \\\"multiple myeloma\\\",\\n \\\"cervical adenocarcinoma\\\",\\n \\\"liver disease\\\",\\n \\\"cirrhosis of liver\\\",\\n \\\"ischemic cardiomyopathy\\\",\\n \\\"lymphoid neoplasm\\\",\\n \\\"coronary artery disease\\\",\\n \\\"prostate carcinoma\\\",\\n \\\"aortic aneurysm\\\",\\n \\\"fibrosarcoma\\\",\\n \\\"hypertrophy\\\",\\n \\\"actinic keratosis\\\",\\n \\\"anaplastic astrocytoma\\\",\\n \\\"anaplastic oligodendroglioma\\\",\\n \\\"cardiac hypertrophy\\\",\\n \\\"AIDS dementia\\\",\\n \\\"pancreatic carcinoma\\\",\\n \\\"prostate intraepithelial neoplasia\\\",\\n \\\"thyroid carcinoma\\\",\\n \\\"insulin resistance\\\",\\n \\\"esophageal carcinoma\\\",\\n \\\"ovarian serous adenocarcinoma\\\",\\n \\\"rhabdomyosarcoma\\\",\\n \\\"medulloblastoma\\\",\\n \\\"acute megakaryoblastic leukaemia\\\",\\n \\\"hepatitis C virus infection\\\",\\n \\\"non-small cell lung carcinoma\\\",\\n \\\"pleomorphic liposarcoma\\\",\\n \\\"kidney disease\\\",\\n \\\"non-alcoholic fatty liver disease\\\",\\n \\\"Pick disease\\\",\\n \\\"testicular seminoma\\\",\\n \\\"osteomyelitis\\\",\\n \\\"spina bifida\\\",\\n \\\"heart failure\\\",\\n \\\"vitamin D deficiency\\\",\\n \\\"inflammatory bowel disease\\\",\\n \\\"diabetic retinopathy\\\",\\n \\\"heart disease\\\",\\n \\\"psoriatic arthritis\\\",\\n \\\"lung disease\\\",\\n \\\"dental caries\\\",\\n \\\"serous adenocarcinoma\\\",\\n \\\"retinopathy\\\",\\n \\\"adrenal gland neoplasm\\\"\\n ],\\n \\\"tissue_specific_expression\\\": {\\n \\\"frontal lobe\\\": -1,\\n \\\"endothelial cell of umbilical vein (resting)\\\": 2,\\n \\\"zone of skin\\\": 0,\\n \\\"regulatory T cell\\\": 1,\\n \\\"pancreas\\\": -1,\\n \\\"suprapubic skin\\\": -1,\\n \\\"temporal lobe\\\": -1,\\n \\\"parathyroid gland\\\": -1,\\n \\\"spleen\\\": -1,\\n \\\"Brodmann (1909) area 9\\\": -1,\\n \\\"breast\\\": -1,\\n \\\"Brodmann (1909) area 24\\\": -1,\\n \\\"alternatively activated macrophage\\\": 2,\\n \\\"segmented neutrophil of bone marrow\\\": 4,\\n \\\"placenta\\\": -1,\\n \\\"mature eosinophil\\\": 1,\\n \\\"granulocyte monocyte progenitor cell\\\": 0,\\n \\\"gall bladder\\\": -1,\\n \\\"esophagus muscularis mucosa\\\": -1,\\n \\\"seminal vesicle\\\": -1,\\n \\\"endocervix\\\": -1,\\n \\\"lower leg skin\\\": -1,\\n \\\"megakaryocyte-erythroid progenitor cell\\\": 0,\\n \\\"endothelial cell of umbilical vein (proliferating)\\\": 2,\\n \\\"CD8-positive, alpha-beta T cell\\\": 3,\\n \\\"cerebral cortex\\\": -1,\\n \\\"CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\": 4,\\n \\\"hippocampus proper\\\": -1,\\n \\\"uterus\\\": -1,\\n \\\"CD4-positive, alpha-beta T cell\\\": 3,\\n \\\"tonsil\\\": -1,\\n \\\"esophagus\\\": 0,\\n \\\"transverse colon\\\": -1,\\n \\\"pituitary gland\\\": -1,\\n \\\"coronary artery\\\": -1,\\n \\\"memory B cell\\\": 0,\\n \\\"sigmoid colon\\\": -1,\\n \\\"cerebellum\\\": -1,\\n \\\"erythroblast\\\": 2,\\n \\\"prefrontal cortex\\\": -1,\\n \\\"nucleus accumbens\\\": -1,\\n \\\"adipose tissue\\\": 0,\\n \\\"effector memory CD8-positive, alpha-beta T cell\\\": 1,\\n \\\"vermiform appendix\\\": -1,\\n \\\"greater omentum\\\": -1,\\n \\\"hematopoietic multipotent progenitor cell\\\": 1,\\n \\\"leukocyte\\\": 2,\\n \\\"adrenal gland\\\": -1,\\n \\\"atrium auricular region\\\": -1,\\n \\\"thyroid gland\\\": 0,\\n \\\"tibial artery\\\": -1,\\n \\\"common lymphoid progenitor\\\": 3,\\n \\\"urinary bladder\\\": -1,\\n \\\"duodenum\\\": -1,\\n \\\"heart muscle\\\": -1,\\n \\\"small intestine\\\": -1,\\n \\\"neutrophilic metamyelocyte\\\": 3,\\n \\\"minor salivary gland\\\": -1,\\n \\\"rectum\\\": 0,\\n \\\"ovary\\\": -1,\\n \\\"substantia nigra\\\": -1,\\n \\\"subcutaneous adipose tissue\\\": -1,\\n \\\"class switched memory B cell\\\": 1,\\n \\\"fallopian tube\\\": -1,\\n \\\"esophagus mucosa\\\": -1,\\n \\\"CD38-negative naive B cell\\\": 0,\\n \\\"bronchus\\\": -1,\\n \\\"EBV-transformed lymphocyte\\\": 0,\\n \\\"small intestine Peyer's patch\\\": -1,\\n \\\"kidney\\\": -1,\\n \\\"hippocampus\\\": -1,\\n \\\"macrophage\\\": 1,\\n \\\"aorta\\\": -1,\\n \\\"skeletal muscle tissue\\\": -1,\\n \\\"CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\": 4,\\n \\\"caudate-putamen\\\": -1,\\n \\\"liver\\\": -1,\\n \\\"cytotoxic CD56-dim natural killer cell\\\": 2,\\n \\\"mature neutrophil\\\": 2,\\n \\\"hypothalamus\\\": -1,\\n \\\"transformed skin fibroblast\\\": -1,\\n \\\"bone marrow\\\": -1,\\n \\\"inflammatory macrophage\\\": 0,\\n \\\"cortex of kidney\\\": -1,\\n \\\"lung\\\": -1,\\n \\\"epididymis\\\": -1,\\n \\\"abdomen\\\": -1,\\n \\\"saliva-secreting gland\\\": -1,\\n \\\"nasopharynx\\\": -1,\\n \\\"colon\\\": 0,\\n \\\"cerebellar hemisphere\\\": -1,\\n \\\"stomach\\\": -1,\\n \\\"testis\\\": -1,\\n \\\"smooth muscle tissue\\\": 0,\\n \\\"putamen\\\": -1,\\n \\\"CD4-positive, alpha-beta thymocyte\\\": 5,\\n \\\"C1 segment of cervical spinal cord\\\": 0,\\n \\\"blood\\\": -1,\\n \\\"hematopoietic stem cell\\\": 1,\\n \\\"caudate nucleus\\\": -1,\\n \\\"amygdala\\\": -1,\\n \\\"brain\\\": 0,\\n \\\"central memory CD8-positive, alpha-beta T cell\\\": 1,\\n \\\"effector memory CD4-positive, alpha-beta T cell\\\": 1,\\n \\\"ectocervix\\\": -1,\\n \\\"prostate gland\\\": -1,\\n \\\"conventional dendritic cell\\\": 4,\\n \\\"central memory CD4-positive, alpha-beta T cell\\\": 1,\\n \\\"heart left ventricle\\\": -1,\\n \\\"CD14-positive, CD16-negative classical monocyte\\\": 0,\\n \\\"vagina\\\": -1,\\n \\\"esophagogastric junction\\\": -1,\\n \\\"lymph node\\\": -1,\\n \\\"endometrium\\\": -1,\\n \\\"heart\\\": -1,\\n \\\"oral mucosa\\\": -1,\\n \\\"CD8-positive, alpha-beta thymocyte\\\": 4,\\n \\\"common myeloid progenitor\\\": 0,\\n \\\"tibial nerve\\\": -1,\\n \\\"plasma cell\\\": -1\\n },\\n \\\"is_essential\\\": false,\\n \\\"genetic_constraint\\\": {\\n \\\"syn\\\": 0.11195000261068344,\\n \\\"mis\\\": 4.47730016708374,\\n \\\"lof\\\": 1.0\\n },\\n \\\"pharmacovigilance\\\": []\\n },\\n \\\"transcriptome\\\": {\\n \\\"transcripts\\\": {},\\n \\\"isoforms\\\": {\\n \\\"general_localization\\\": {\\n \\\"name\\\": \\\"general_localization\\\",\\n \\\"aliases\\\": [],\\n \\\"status\\\": null,\\n \\\"locations\\\": [\\n \\\"Cytoplasm\\\",\\n \\\"Nucleus\\\"\\n ],\\n \\\"notes\\\": [\\n \\\"Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)\\\",\\n \\\"TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta\\\"\\n ]\\n }\\n },\\n \\\"avg_exons_per_transcript\\\": null,\\n \\\"transcript_count\\\": 0,\\n \\\"total_exon_count\\\": null,\\n \\\"median_transcript_span_bp\\\": null,\\n \\\"max_transcript_span_bp\\\": null\\n },\\n \\\"gwas_profile\\\": null,\\n \\\"variants\\\": {},\\n \\\"traits\\\": [],\\n \\\"binding_peaks\\\": {},\\n \\\"mirna_targets\\\": {},\\n \\\"alliancegenome_info\\\": [],\\n \\\"viral_interactions\\\": [],\\n \\\"text_summaries_from_tools\\\": [\\n \\\"*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74\\\",\\n \\\"*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\",\\n \\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) \\\\u2014 TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.\\\",\\n \\\"*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Ch\\\\u00e9diak-Higashi syndrome, \\\\u00c5land Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent M\\\\u00fcllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0\\\",\\n \\\"*HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709).\\\",\\n \\\"*GO: SMAD2 representative GO terms: C:cytoplasm, C:nucleus, C:chromatin, C:heteromeric SMAD protein complex, C:cytosol, C:nucleoplasm, F:DNA-binding transcription factor activity, F:disordered domain specific binding, F:identical protein binding, F:transforming growth factor beta receptor binding, F:cis-regulatory region sequence-specific DNA binding, F:metal ion binding, P:primary miRNA processing, P:lung development, P:endoderm formation, P:odontoblast differentiation, P:determination of left/right asymmetry in lateral mesoderm, P:gastrulation.\\\"\\n ],\\n \\\"tools_run\\\": [\\n \\\"EntityExtraction\\\",\\n \\\"MSigDB\\\",\\n \\\"uniprot_entry\\\",\\n \\\"BioGRID\\\",\\n \\\"OpenTargets\\\",\\n \\\"reactome_pathways\\\",\\n \\\"humanbase_predictions\\\"\\n ]\\n },\\n \\\"SMAD3\\\": {\\n \\\"identifiers\\\": {\\n \\\"symbol\\\": \\\"SMAD3\\\",\\n \\\"entrez_id\\\": \\\"4088\\\",\\n \\\"uniprot_id\\\": \\\"P84022\\\",\\n \\\"ensembl_id\\\": null,\\n \\\"aliases\\\": [],\\n \\\"gene_type\\\": null\\n },\\n \\\"location\\\": null,\\n \\\"annotations\\\": {\\n \\\"go_annotations\\\": [\\n \\\"C:SMAD protein complex\\\",\\n \\\"C:chromatin\\\",\\n \\\"C:ciliary basal body\\\",\\n \\\"C:cytoplasm\\\",\\n \\\"C:cytosol\\\",\\n \\\"C:heteromeric SMAD protein complex\\\",\\n \\\"C:intracellular membrane-bounded organelle\\\",\\n \\\"C:nuclear inner membrane\\\",\\n \\\"C:nucleoplasm\\\",\\n \\\"C:nucleus\\\",\\n \\\"C:plasma membrane\\\",\\n \\\"C:receptor complex\\\",\\n \\\"C:transcription regulator complex\\\",\\n \\\"F:DEAD/H-box RNA helicase binding\\\",\\n \\\"F:DNA binding\\\",\\n \\\"F:DNA-binding transcription activator activity, RNA polymerase II-specific\\\",\\n \\\"F:DNA-binding transcription factor activity\\\",\\n \\\"F:DNA-binding transcription factor activity, RNA polymerase II-specific\\\",\\n \\\"F:DNA-binding transcription factor binding\\\",\\n \\\"F:DNA-binding transcription repressor activity\\\",\\n \\\"F:I-SMAD binding\\\",\\n \\\"F:R-SMAD binding\\\",\\n \\\"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding\\\",\\n \\\"F:RNA polymerase II-specific DNA-binding transcription factor binding\\\",\\n \\\"F:bHLH transcription factor binding\\\",\\n \\\"F:beta-catenin binding\\\",\\n \\\"F:chromatin DNA binding\\\",\\n \\\"F:cis-regulatory region sequence-specific DNA binding\\\",\\n \\\"F:co-SMAD binding\\\",\\n \\\"F:collagen binding\\\",\\n \\\"F:identical protein binding\\\",\\n \\\"F:nuclear glucocorticoid receptor binding\\\",\\n \\\"F:nuclear mineralocorticoid receptor binding\\\",\\n \\\"F:nuclear receptor binding\\\",\\n \\\"F:phosphatase binding\\\",\\n \\\"F:promoter-specific chromatin binding\\\",\\n \\\"F:protein homodimerization activity\\\",\\n \\\"F:protein kinase binding\\\",\\n \\\"F:sequence-specific DNA binding\\\",\\n \\\"F:sterol response element binding\\\",\\n \\\"F:transcription cis-regulatory region binding\\\",\\n \\\"F:transcription coactivator binding\\\",\\n \\\"F:transcription corepressor binding\\\",\\n \\\"F:transforming growth factor beta receptor binding\\\",\\n \\\"F:ubiquitin binding\\\",\\n \\\"F:ubiquitin protein ligase binding\\\",\\n \\\"F:zinc ion binding\\\",\\n \\\"P:JNK cascade\\\",\\n \\\"P:SMAD protein signal transduction\\\",\\n \\\"P:T cell activation\\\",\\n \\\"P:activin receptor signaling pathway\\\",\\n \\\"P:adrenal gland development\\\",\\n \\\"P:anatomical structure morphogenesis\\\",\\n \\\"P:apoptotic signaling pathway\\\",\\n \\\"P:cell differentiation\\\",\\n \\\"P:cell population proliferation\\\",\\n \\\"P:cell-cell junction organization\\\",\\n \\\"P:cellular response to glucose stimulus\\\",\\n \\\"P:cellular response to transforming growth factor beta stimulus\\\",\\n \\\"P:cellular response to virus\\\",\\n \\\"P:developmental growth\\\",\\n \\\"P:embryonic cranial skeleton morphogenesis\\\",\\n \\\"P:embryonic foregut morphogenesis\\\",\\n \\\"P:embryonic pattern specification\\\",\\n \\\"P:endoderm development\\\",\\n \\\"P:extrinsic apoptotic signaling pathway\\\",\\n \\\"P:heart looping\\\",\\n \\\"P:immune response\\\",\\n \\\"P:immune system development\\\",\\n \\\"P:in utero embryonic development\\\",\\n \\\"P:lens fiber cell differentiation\\\",\\n \\\"P:liver development\\\",\\n \\\"P:mesoderm formation\\\",\\n \\\"P:negative regulation of apoptotic process\\\",\\n \\\"P:negative regulation of cardiac muscle hypertrophy in response to stress\\\",\\n \\\"P:negative regulation of cell differentiation\\\",\\n \\\"P:negative regulation of cell growth\\\",\\n \\\"P:negative regulation of cell population proliferation\\\",\\n \\\"P:negative regulation of cytosolic calcium ion concentration\\\",\\n \\\"P:negative regulation of fat cell differentiation\\\",\\n \\\"P:negative regulation of gene expression\\\",\\n \\\"P:negative regulation of inflammatory response\\\",\\n \\\"P:negative regulation of lung blood pressure\\\",\\n \\\"P:negative regulation of miRNA transcription\\\",\\n \\\"P:negative regulation of ossification\\\",\\n \\\"P:negative regulation of osteoblast differentiation\\\",\\n \\\"P:negative regulation of osteoblast proliferation\\\",\\n \\\"P:negative regulation of protein catabolic process\\\",\\n \\\"P:negative regulation of transcription by RNA polymerase II\\\",\\n \\\"P:negative regulation of wound healing\\\",\\n \\\"P:nodal signaling pathway\\\",\\n \\\"P:osteoblast development\\\",\\n \\\"P:paraxial mesoderm morphogenesis\\\",\\n \\\"P:pericardium development\\\",\\n \\\"P:positive regulation of DNA-templated transcription\\\",\\n \\\"P:positive regulation of SMAD protein signal transduction\\\",\\n \\\"P:positive regulation of bone mineralization\\\",\\n \\\"P:positive regulation of canonical Wnt signaling pathway\\\",\\n \\\"P:positive regulation of cell migration\\\",\\n \\\"P:positive regulation of chondrocyte differentiation\\\",\\n \\\"P:positive regulation of epithelial to mesenchymal transition\\\",\\n \\\"P:positive regulation of extracellular matrix assembly\\\",\\n \\\"P:positive regulation of focal adhesion assembly\\\",\\n \\\"P:positive regulation of gene expression\\\",\\n \\\"P:positive regulation of interleukin-1 beta production\\\",\\n \\\"P:positive regulation of miRNA transcription\\\",\\n \\\"P:positive regulation of nitric oxide biosynthetic process\\\",\\n \\\"P:positive regulation of positive chemotaxis\\\",\\n \\\"P:positive regulation of protein import into nucleus\\\",\\n \\\"P:positive regulation of stress fiber assembly\\\",\\n \\\"P:positive regulation of transcription by RNA polymerase II\\\",\\n \\\"P:positive regulation of transforming growth factor beta3 production\\\",\\n \\\"P:primary miRNA processing\\\",\\n \\\"P:protein stabilization\\\",\\n \\\"P:regulation of DNA-templated transcription\\\",\\n \\\"P:regulation of epithelial cell proliferation\\\",\\n \\\"P:regulation of immune response\\\",\\n \\\"P:regulation of miRNA transcription\\\",\\n \\\"P:regulation of mitochondrial membrane potential\\\",\\n \\\"P:regulation of striated muscle tissue development\\\",\\n \\\"P:regulation of transcription by RNA polymerase II\\\",\\n \\\"P:regulation of transforming growth factor beta receptor signaling pathway\\\",\\n \\\"P:regulation of transforming growth factor beta2 production\\\",\\n \\\"P:release of cytochrome c from mitochondria\\\",\\n \\\"P:response to angiotensin\\\",\\n \\\"P:response to hypoxia\\\",\\n \\\"P:signal transduction involved in regulation of gene expression\\\",\\n \\\"P:somitogenesis\\\",\\n \\\"P:thyroid gland development\\\",\\n \\\"P:transdifferentiation\\\",\\n \\\"P:transforming growth factor beta receptor signaling pathway\\\",\\n \\\"P:trophoblast cell migration\\\",\\n \\\"P:ureteric bud development\\\",\\n \\\"P:wound healing\\\"\\n ],\\n \\\"functions\\\": [\\n \\\"Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator\\\"\\n ],\\n \\\"diseases\\\": [\\n \\\"Colorectal cancer\\\",\\n \\\"Loeys-Dietz syndrome 3\\\"\\n ],\\n \\\"pathways\\\": [\\n \\\"Cytokine Signaling in Immune system\\\",\\n \\\"Interleukin-1 family signaling\\\",\\n \\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\",\\n \\\"Developmental Biology\\\",\\n \\\"Viral Infection Pathways\\\",\\n \\\"Signaling by TGFBR3\\\",\\n \\\"Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer\\\",\\n \\\"Signaling by Interleukins\\\",\\n \\\"Deubiquitination\\\",\\n \\\"Signaling by NOTCH\\\",\\n \\\"TGF-beta receptor signaling activates SMADs\\\",\\n \\\"Signaling by TGFB family members\\\",\\n \\\"Loss of Function of TGFBR1 in Cancer\\\",\\n \\\"RUNX3 regulates CDKN1A transcription\\\",\\n \\\"SARS-CoV-1 targets host intracellular signalling and regulatory pathways\\\",\\n \\\"Signaling by TGF-beta Receptor Complex\\\",\\n \\\"TGFBR1 KD Mutants in Cancer\\\",\\n \\\"Post-translational protein modification\\\",\\n \\\"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes\\\",\\n \\\"TGFBR3 expression\\\",\\n \\\"Disease\\\",\\n \\\"Generic Transcription Pathway\\\",\\n \\\"Metabolism of proteins\\\",\\n \\\"Gene expression (Transcription)\\\",\\n \\\"Signal Transduction\\\",\\n \\\"SARS-CoV-1-host interactions\\\",\\n \\\"FOXO-mediated transcription\\\",\\n \\\"Infectious disease\\\",\\n \\\"Gastrulation\\\",\\n \\\"RNA Polymerase II Transcription\\\",\\n \\\"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription\\\",\\n \\\"NOTCH4 Intracellular Domain Regulates Transcription\\\",\\n \\\"FOXO-mediated transcription of cell cycle genes\\\",\\n \\\"Loss of Function of SMAD2/3 in Cancer\\\",\\n \\\"SMAD4 MH2 Domain Mutants in Cancer\\\",\\n \\\"Diseases of signal transduction by growth factor receptors and second messengers\\\",\\n \\\"SARS-CoV Infections\\\",\\n \\\"Formation of axial mesoderm\\\",\\n \\\"SARS-CoV-1 Infection\\\",\\n \\\"Germ layer formation at gastrulation\\\",\\n \\\"Signaling by NOTCH4\\\",\\n \\\"Downregulation of TGF-beta receptor signaling\\\",\\n \\\"Interleukin-37 signaling\\\",\\n \\\"Formation of definitive endoderm\\\",\\n \\\"RUNX3 regulates BCL2L11 (BIM) transcription\\\",\\n \\\"Ub-specific processing proteases\\\",\\n \\\"Loss of Function of SMAD4 in Cancer\\\",\\n \\\"Downregulation of SMAD2/3:SMAD4 transcriptional activity\\\",\\n \\\"Immune System\\\",\\n \\\"SMAD2/3 MH2 Domain Mutants in Cancer\\\",\\n \\\"Transcriptional regulation by RUNX3\\\",\\n \\\"Signaling by Activin\\\",\\n \\\"Signaling by TGF-beta Receptor Complex in Cancer\\\",\\n \\\"Signaling by NODAL\\\"\\n ],\\n \\\"cell_localizations\\\": [],\\n \\\"predicted_go\\\": [],\\n \\\"predicted_disease\\\": []\\n },\\n \\\"interactions\\\": {\\n \\\"human_interactions\\\": {\\n \\\"Affinity Capture-Luminescence\\\": [\\n 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\\\"PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN\\\",\\n \\\"WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING\\\",\\n \\\"LEI_MYB_TARGETS\\\",\\n \\\"FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL\\\",\\n \\\"WP_ENDODERM_DIFFERENTIATION\\\",\\n \\\"WP_TGFBETA_RECEPTOR_SIGNALING\\\",\\n \\\"MARTINEZ_RESPONSE_TO_TRABECTEDIN\\\",\\n \\\"WP_HEPATITIS_B_INFECTION\\\",\\n \\\"WP_CANCER_PATHWAYS\\\",\\n \\\"WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER\\\",\\n \\\"REACTOME_INFECTIOUS_DISEASE\\\",\\n \\\"REACTOME_SIGNALING_BY_INTERLEUKINS\\\",\\n \\\"SANA_TNF_SIGNALING_UP\\\",\\n \\\"REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS\\\",\\n \\\"JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP\\\",\\n \\\"WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES\\\",\\n \\\"REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3\\\",\\n \\\"REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION\\\",\\n \\\"NAKAMURA_ADIPOGENESIS_LATE_DN\\\",\\n \\\"REACTOME_SARS_COV_1_HOST_INTERACTIONS\\\",\\n \\\"REACTOME_SIGNALING_BY_NODAL\\\",\\n \\\"REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION\\\",\\n \\\"PID_SMAD2_3NUCLEAR_PATHWAY\\\",\\n \\\"CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN\\\",\\n \\\"REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION\\\",\\n \\\"REACTOME_FORMATION_OF_AXIAL_MESODERM\\\",\\n \\\"GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN\\\",\\n \\\"WP_CELL_CYCLE\\\",\\n \\\"DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN\\\",\\n \\\"CAIRO_HEPATOBLASTOMA_CLASSES_DN\\\",\\n \\\"PID_MYC_ACTIV_PATHWAY\\\",\\n \\\"SHEPARD_CRASH_AND_BURN_MUTANT_DN\\\",\\n \\\"ZHENG_BOUND_BY_FOXP3\\\",\\n \\\"WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES\\\",\\n \\\"RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP\\\",\\n \\\"REACTOME_INTERLEUKIN_37_SIGNALING\\\",\\n \\\"FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP\\\",\\n \\\"WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER\\\",\\n \\\"DACOSTA_UV_RESPONSE_VIA_ERCC3_DN\\\",\\n \\\"REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM\\\",\\n \\\"GENTILE_UV_RESPONSE_CLUSTER_D6\\\",\\n \\\"GENTILE_UV_HIGH_DOSE_DN\\\",\\n \\\"REACTOME_DEUBIQUITINATION\\\",\\n \\\"REACTOME_SARS_COV_INFECTIONS\\\",\\n \\\"BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN\\\",\\n \\\"WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS\\\",\\n \\\"TURJANSKI_MAPK1_AND_MAPK2_TARGETS\\\",\\n \\\"PULVER_FOREY_CELLCYCLE_PEAKING_M\\\",\\n \\\"REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER\\\",\\n \\\"REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES\\\",\\n \\\"ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP\\\",\\n \\\"REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES\\\",\\n \\\"BENPORATH_NANOG_TARGETS\\\",\\n \\\"LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP\\\",\\n \\\"WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER\\\",\\n \\\"DOANE_RESPONSE_TO_ANDROGEN_DN\\\",\\n \\\"REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING\\\",\\n \\\"MARTENS_BOUND_BY_PML_RARA_FUSION\\\",\\n \\\"FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS\\\",\\n \\\"MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN\\\",\\n \\\"RIZ_ERYTHROID_DIFFERENTIATION_6HR\\\",\\n \\\"REACTOME_SARS_COV_1_INFECTION\\\",\\n \\\"WP_HIPPO_SIGNALING_REGULATION\\\",\\n \\\"RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP\\\",\\n \\\"JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP\\\",\\n \\\"PID_MYC_REPRESS_PATHWAY\\\",\\n \\\"WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE\\\",\\n \\\"ONKEN_UVEAL_MELANOMA_UP\\\",\\n \\\"PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2\\\",\\n \\\"PHONG_TNF_RESPONSE_VIA_P38_PARTIAL\\\",\\n \\\"JOHNSTONE_PARVB_TARGETS_2_UP\\\",\\n \\\"OKUMURA_INFLAMMATORY_RESPONSE_LPS\\\",\\n \\\"BIOCARTA_TOB1_PATHWAY\\\",\\n \\\"GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN\\\",\\n \\\"KEGG_CELL_CYCLE\\\",\\n \\\"WP_1P36_COPY_NUMBER_VARIATION_SYNDROME\\\",\\n \\\"DAZARD_RESPONSE_TO_UV_NHEK_DN\\\",\\n \\\"WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY\\\",\\n \\\"OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN\\\",\\n \\\"RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN\\\",\\n \\\"REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM\\\",\\n \\\"WP_AGERAGE_PATHWAY\\\",\\n \\\"KEGG_PANCREATIC_CANCER\\\",\\n \\\"MARSON_BOUND_BY_FOXP3_UNSTIMULATED\\\",\\n \\\"FIGUEROA_AML_METHYLATION_CLUSTER_3_UP\\\",\\n \\\"LINDGREN_BLADDER_CANCER_CLUSTER_3_DN\\\",\\n \\\"REACTOME_GASTRULATION\\\",\\n \\\"REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION\\\",\\n \\\"BENPORATH_MYC_MAX_TARGETS\\\",\\n \\\"WP_INTEGRATED_CANCER_PATHWAY\\\",\\n \\\"KEGG_CHRONIC_MYELOID_LEUKEMIA\\\",\\n \\\"REACTOME_SIGNALING_BY_TGFBR3\\\",\\n \\\"BENPORATH_SOX2_TARGETS\\\",\\n \\\"KEGG_TGF_BETA_SIGNALING_PATHWAY\\\",\\n \\\"WP_ANDROGEN_RECEPTOR_SIGNALING\\\",\\n \\\"PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2\\\",\\n \\\"JOHNSTONE_PARVB_TARGETS_3_UP\\\",\\n \\\"BIOCARTA_TGFB_PATHWAY\\\",\\n \\\"CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN\\\",\\n \\\"REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY\\\",\\n \\\"KEGG_PATHWAYS_IN_CANCER\\\",\\n \\\"WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE\\\",\\n \\\"WP_UROTENSINIIMEDIATED_SIGNALING\\\",\\n \\\"WP_MESODERMAL_COMMITMENT_PATHWAY\\\",\\n \\\"TSAI_RESPONSE_TO_IONIZING_RADIATION\\\",\\n \\\"LAMB_CCND1_TARGETS\\\",\\n \\\"REACTOME_VIRAL_INFECTION_PATHWAYS\\\",\\n \\\"WP_TGFB_SMAD_SIGNALING\\\",\\n \\\"DAZARD_UV_RESPONSE_CLUSTER_G6\\\",\\n \\\"REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS\\\",\\n \\\"REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX\\\",\\n \\\"WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION\\\",\\n \\\"REACTOME_SIGNALING_BY_NOTCH\\\",\\n \\\"FRASOR_RESPONSE_TO_ESTRADIOL_DN\\\",\\n \\\"ZIRN_TRETINOIN_RESPONSE_WT1_UP\\\",\\n \\\"KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3\\\",\\n \\\"BROWNE_HCMV_INFECTION_8HR_DN\\\",\\n \\\"ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF\\\",\\n \\\"REN_ALVEOLAR_RHABDOMYOSARCOMA_DN\\\",\\n \\\"REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION\\\",\\n \\\"PID_HIF1_TFPATHWAY\\\",\\n \\\"GRUETZMANN_PANCREATIC_CANCER_UP\\\",\\n \\\"CHICAS_RB1_TARGETS_CONFLUENT\\\",\\n \\\"YEMELYANOV_GR_TARGETS_DN\\\",\\n \\\"WP_OVARIAN_INFERTILITY\\\",\\n \\\"PHONG_TNF_RESPONSE_NOT_VIA_P38\\\",\\n \\\"WP_ADIPOGENESIS\\\",\\n \\\"DANG_BOUND_BY_MYC\\\",\\n \\\"WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING\\\",\\n \\\"DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN\\\",\\n \\\"BIOCARTA_G1_PATHWAY\\\",\\n \\\"REACTOME_SIGNALING_BY_NOTCH4\\\",\\n \\\"SERVITJA_ISLET_HNF1A_TARGETS_UP\\\",\\n \\\"WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS\\\",\\n \\\"WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY\\\",\\n \\\"WP_NEOVASCULARIZATION_PROCESSES\\\",\\n \\\"REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER\\\",\\n \\\"KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY\\\",\\n \\\"PID_SMAD2_3PATHWAY\\\",\\n \\\"CHANDRAN_METASTASIS_DN\\\",\\n \\\"WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT\\\",\\n \\\"PEREZ_TP53_TARGETS\\\",\\n \\\"KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY\\\",\\n \\\"KIM_WT1_TARGETS_12HR_UP\\\",\\n \\\"WP_BURN_WOUND_HEALING\\\",\\n \\\"REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER\\\",\\n \\\"WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER\\\",\\n \\\"PID_TGFBR_PATHWAY\\\",\\n \\\"WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY\\\",\\n \\\"BROWNE_HCMV_INFECTION_6HR_DN\\\",\\n \\\"REACTOME_FOXO_MEDIATED_TRANSCRIPTION\\\",\\n \\\"REACTOME_TGFBR3_EXPRESSION\\\",\\n \\\"SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1\\\",\\n \\\"KEGG_COLORECTAL_CANCER\\\",\\n \\\"RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN\\\",\\n \\\"REACTOME_SIGNALING_BY_ACTIVIN\\\",\\n \\\"REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS\\\"\\n ],\\n \\\"C3\\\": [\\n \\\"WGGAATGY_TEF1_Q6\\\",\\n \\\"MIR302D_5P\\\",\\n \\\"GTTAAAG_MIR302B\\\",\\n \\\"MIR8080\\\",\\n \\\"PXR_Q2\\\",\\n \\\"SRY_02\\\",\\n \\\"GGCAGAC_MIR346\\\",\\n \\\"HDAC4_TARGET_GENES\\\",\\n \\\"ZNF563_TARGET_GENES\\\",\\n \\\"ZNF766_TARGET_GENES\\\",\\n \\\"MEF2C_TARGET_GENES\\\",\\n \\\"ZFHX3_TARGET_GENES\\\",\\n \\\"TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497\\\",\\n \\\"MIR524_5P\\\",\\n \\\"MIR6129\\\",\\n \\\"ZFP3_TARGET_GENES\\\",\\n \\\"E12_Q6\\\",\\n \\\"ZSCAN30_TARGET_GENES\\\",\\n \\\"GREB1_TARGET_GENES\\\",\\n \\\"MIR3120_5P\\\",\\n \\\"MIR668_3P\\\",\\n \\\"MYOD_Q6_01\\\",\\n \\\"RYTTCCTG_ETS2_B\\\",\\n \\\"MIR6127\\\",\\n \\\"MIR145_5P\\\",\\n \\\"TAL1BETAE47_01\\\",\\n \\\"SKIL_TARGET_GENES\\\",\\n \\\"MIR6130\\\",\\n \\\"ZNF436_TARGET_GENES\\\",\\n \\\"AACTGGA_MIR145\\\",\\n \\\"NR0B1_TARGET_GENES\\\",\\n \\\"KMT2D_TARGET_GENES\\\",\\n \\\"SNAI1_TARGET_GENES\\\",\\n \\\"TAL1ALPHAE47_01\\\",\\n \\\"MED25_TARGET_GENES\\\",\\n \\\"MIR20A_3P\\\",\\n \\\"TFEB_TARGET_GENES\\\",\\n \\\"TBX1_TARGET_GENES\\\",\\n \\\"MIR6886_3P\\\",\\n \\\"AATGTGA_MIR23A_MIR23B\\\",\\n \\\"SUPT16H_TARGET_GENES\\\",\\n \\\"AGCTCCT_MIR28\\\",\\n \\\"NGFIC_01\\\",\\n \\\"MIR3194_3P\\\",\\n \\\"ZNF512B_TARGET_GENES\\\",\\n \\\"TAL1BETAITF2_01\\\",\\n \\\"GATA1_05\\\",\\n \\\"ZNF282_TARGET_GENES\\\",\\n \\\"ZNF740_TARGET_GENES\\\",\\n \\\"ZSCAN2_TARGET_GENES\\\",\\n \\\"MIR6762_5P\\\",\\n \\\"MIR561_3P\\\",\\n \\\"MIR617\\\",\\n \\\"ZNF92_TARGET_GENES\\\",\\n \\\"HMX1_01\\\",\\n \\\"LFA1_Q6\\\",\\n \\\"MIR6845_5P\\\",\\n \\\"DLX2_TARGET_GENES\\\",\\n \\\"SALL4_TARGET_GENES\\\",\\n \\\"MIR520D_5P\\\",\\n \\\"MIR4778_3P\\\",\\n \\\"MIR302B_5P\\\",\\n \\\"MIR6765_3P\\\",\\n \\\"CTTTGTA_MIR524\\\",\\n \\\"MIR4510\\\",\\n \\\"MIR520G_3P_MIR520H\\\",\\n \\\"MIR6133\\\",\\n \\\"MIR5195_3P\\\",\\n \\\"CTAWWWATA_RSRFC4_Q2\\\",\\n \\\"SFMBT1_TARGET_GENES\\\",\\n \\\"ARID5B_TARGET_GENES\\\",\\n \\\"EWSR1_TARGET_GENES\\\",\\n \\\"COUP_DR1_Q6\\\",\\n \\\"MIR3658\\\",\\n \\\"GCTNWTTGK_UNKNOWN\\\",\\n \\\"ZNF596_TARGET_GENES\\\",\\n \\\"ZSCAN5DP_TARGET_GENES\\\",\\n \\\"ATGTCAC_MIR489\\\",\\n \\\"NAB2_TARGET_GENES\\\",\\n \\\"ZNF746_TARGET_GENES\\\",\\n \\\"PBXIP1_TARGET_GENES\\\",\\n \\\"MIR3154\\\",\\n \\\"FXR_IR1_Q6\\\",\\n \\\"MIR5787\\\",\\n \\\"ADNP_TARGET_GENES\\\",\\n \\\"MIR4505\\\"\\n ],\\n \\\"C4\\\": [\\n \\\"MODULE_378\\\",\\n \\\"MODULE_37\\\",\\n \\\"MODULE_57\\\",\\n \\\"MODULE_129\\\",\\n \\\"MODULE_179\\\",\\n \\\"MODULE_3\\\",\\n \\\"MODULE_69\\\",\\n \\\"MODULE_70\\\",\\n \\\"MODULE_117\\\",\\n \\\"MODULE_138\\\",\\n \\\"MODULE_255\\\",\\n \\\"MODULE_459\\\",\\n \\\"MODULE_532\\\",\\n \\\"MODULE_18\\\",\\n \\\"MODULE_136\\\",\\n \\\"MODULE_33\\\",\\n \\\"MODULE_317\\\"\\n ],\\n \\\"C6\\\": [\\n \\\"RPS14_DN.V1_UP\\\"\\n ],\\n \\\"C7\\\": [\\n \\\"GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN\\\",\\n \\\"GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN\\\",\\n \\\"GSE29949_MICROGLIA_VS_DC_BRAIN_DN\\\",\\n \\\"GSE22886_NAIVE_BCELL_VS_DC_UP\\\",\\n \\\"GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP\\\",\\n \\\"GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP\\\",\\n \\\"GSE20366_TREG_VS_TCONV_UP\\\",\\n \\\"GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP\\\",\\n \\\"GSE40443_INDUCED_VS_TOTAL_TREG_UP\\\",\\n \\\"GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP\\\",\\n \\\"GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP\\\",\\n \\\"GSE1460_DP_VS_CD4_THYMOCYTE_DN\\\",\\n \\\"GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN\\\",\\n \\\"GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN\\\",\\n \\\"NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN\\\",\\n \\\"GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN\\\",\\n \\\"GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP\\\",\\n \\\"FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP\\\",\\n \\\"SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP\\\",\\n \\\"GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP\\\",\\n \\\"GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN\\\",\\n \\\"GSE3982_MAC_VS_TH1_DN\\\",\\n \\\"GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP\\\",\\n \\\"GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN\\\",\\n \\\"GSE20727_CTRL_VS_H2O2_TREATED_DC_DN\\\",\\n \\\"GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP\\\",\\n \\\"GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN\\\",\\n \\\"GSE369_IFNG_KO_VS_WT_LIVER_UP\\\",\\n \\\"GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP\\\",\\n \\\"NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP\\\",\\n \\\"GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP\\\",\\n \\\"GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP\\\",\\n \\\"GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP\\\",\\n \\\"GSE7852_LN_VS_FAT_TREG_DN\\\",\\n \\\"GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP\\\",\\n \\\"GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP\\\",\\n \\\"GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN\\\",\\n \\\"GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP\\\",\\n \\\"GSE2585_CTEC_VS_THYMIC_DC_DN\\\",\\n \\\"GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN\\\",\\n \\\"GSE14350_TREG_VS_TEFF_UP\\\",\\n \\\"GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP\\\",\\n \\\"GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN\\\",\\n \\\"GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN\\\",\\n \\\"GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP\\\",\\n \\\"GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN\\\",\\n \\\"GSE14415_INDUCED_TREG_VS_TCONV_DN\\\",\\n \\\"GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN\\\",\\n \\\"GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP\\\",\\n \\\"GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP\\\",\\n \\\"GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP\\\",\\n \\\"GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP\\\",\\n \\\"GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN\\\",\\n \\\"GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP\\\",\\n \\\"GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN\\\",\\n \\\"GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN\\\",\\n \\\"GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN\\\",\\n \\\"GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN\\\",\\n \\\"GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP\\\",\\n \\\"GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN\\\",\\n \\\"NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN\\\",\\n \\\"GSE17186_MEMORY_VS_NAIVE_BCELL_UP\\\",\\n \\\"GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP\\\",\\n \\\"GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN\\\",\\n \\\"GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN\\\",\\n \\\"GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP\\\",\\n \\\"GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP\\\",\\n \\\"GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP\\\",\\n \\\"GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP\\\",\\n \\\"GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN\\\",\\n \\\"GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP\\\",\\n \\\"GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP\\\",\\n \\\"GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN\\\",\\n \\\"GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN\\\",\\n \\\"GSE7852_THYMUS_VS_FAT_TREG_DN\\\",\\n \\\"GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP\\\",\\n \\\"GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP\\\",\\n \\\"GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP\\\",\\n \\\"GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP\\\",\\n \\\"GSE360_CTRL_VS_L_MAJOR_MAC_UP\\\",\\n \\\"GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN\\\",\\n \\\"GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN\\\",\\n \\\"GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP\\\",\\n \\\"GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP\\\",\\n \\\"GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP\\\",\\n \\\"GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP\\\",\\n \\\"GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN\\\",\\n \\\"GSE40273_EOS_KO_VS_WT_TREG_UP\\\",\\n \\\"GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP\\\",\\n \\\"GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP\\\",\\n \\\"GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN\\\",\\n \\\"GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN\\\",\\n \\\"GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP\\\",\\n \\\"GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP\\\",\\n \\\"GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN\\\",\\n \\\"GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP\\\",\\n \\\"GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP\\\",\\n \\\"GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN\\\",\\n \\\"GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN\\\",\\n \\\"GSE12505_WT_VS_E2_2_HET_PDC_UP\\\",\\n \\\"GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP\\\",\\n \\\"GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN\\\",\\n \\\"GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP\\\",\\n \\\"GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN\\\",\\n \\\"GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP\\\",\\n \\\"GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP\\\",\\n \\\"GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP\\\",\\n \\\"GSE27786_CD4_TCELL_VS_NKTCELL_DN\\\",\\n \\\"GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN\\\",\\n \\\"GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP\\\",\\n \\\"NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN\\\",\\n \\\"GSE2585_CTEC_VS_MTEC_THYMUS_UP\\\",\\n \\\"GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN\\\",\\n \\\"NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP\\\",\\n \\\"GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN\\\",\\n \\\"GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP\\\",\\n \\\"GSE7764_NKCELL_VS_SPLENOCYTE_UP\\\",\\n \\\"GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN\\\",\\n \\\"GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP\\\",\\n \\\"GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN\\\",\\n \\\"GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN\\\",\\n \\\"GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP\\\",\\n \\\"GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN\\\",\\n \\\"GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN\\\",\\n \\\"GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP\\\",\\n \\\"GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP\\\"\\n ],\\n \\\"C8\\\": [\\n \\\"FAN_OVARY_CL11_MURAL_GRANULOSA_CELL\\\",\\n \\\"MURARO_PANCREAS_DUCTAL_CELL\\\",\\n \\\"GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS\\\",\\n \\\"FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2\\\",\\n \\\"HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL\\\",\\n \\\"HU_FETAL_RETINA_FIBROBLAST\\\",\\n \\\"HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL\\\",\\n \\\"MURARO_PANCREAS_ACINAR_CELL\\\",\\n \\\"HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL\\\",\\n \\\"HU_FETAL_RETINA_RPE\\\"\\n ]\\n }\\n },\\n \\\"omim\\\": {\\n \\\"phenotype_annotations\\\": []\\n },\\n \\\"disgenet\\\": {\\n \\\"disease_annotations\\\": []\\n },\\n \\\"open_targets\\\": {\\n \\\"disease_annotations\\\": [\\n \\\"Large for gestational age\\\",\\n \\\"Alopecia\\\",\\n \\\"Abnormality of the cardiovascular system\\\",\\n \\\"Mitral valve prolapse\\\",\\n \\\"Congestive heart failure\\\",\\n \\\"Patent ductus arteriosus\\\",\\n \\\"Dilated cardiomyopathy\\\",\\n \\\"Bicuspid aortic valve\\\",\\n \\\"Right ventricular hypertrophy\\\",\\n \\\"Myocardial fibrosis\\\",\\n \\\"Hallux valgus\\\",\\n \\\"Increased total eosinophil count\\\",\\n \\\"Acute kidney injury\\\",\\n \\\"Renal artery stenosis\\\",\\n \\\"Hypoglycemia\\\",\\n \\\"Glucose intolerance\\\",\\n \\\"Abnormal thrombosis\\\",\\n \\\"Rectal prolapse\\\",\\n \\\"Esophageal stricture\\\",\\n \\\"Pulmonary hypoplasia\\\",\\n \\\"Asthma\\\",\\n \\\"Cerebral cortical atrophy\\\",\\n \\\"Ischemic stroke\\\",\\n \\\"Aortic root aneurysm\\\",\\n \\\"Aortic dissection\\\",\\n \\\"Spontaneous pneumothorax\\\",\\n \\\"Vascular dilatation\\\",\\n \\\"Cerebral ischemia\\\",\\n \\\"Immunodeficiency\\\",\\n \\\"Systemic lupus erythematosus\\\",\\n \\\"Oral leukoplakia\\\",\\n \\\"Autoimmunity\\\",\\n \\\"Hyperglycemia\\\",\\n \\\"Hyperlipidemia\\\",\\n \\\"Hypercholesterolemia\\\",\\n \\\"Back pain\\\",\\n \\\"Muscular dystrophy\\\",\\n \\\"Hernia of the abdominal wall\\\",\\n \\\"Cachexia\\\",\\n \\\"Ascending aortic dissection\\\",\\n \\\"Venous thrombosis\\\",\\n \\\"Ascending tubular aorta aneurysm\\\",\\n \\\"Ureteral obstruction\\\",\\n \\\"Airway obstruction\\\",\\n \\\"Pituitary prolactin cell adenoma\\\",\\n \\\"Premature ovarian insufficiency\\\",\\n \\\"Intervertebral disk degeneration\\\",\\n \\\"Lipodystrophy\\\",\\n \\\"Hamartoma\\\",\\n \\\"Chordoma\\\",\\n \\\"Stress urinary incontinence\\\",\\n \\\"Inflammatory abnormality of the skin\\\",\\n \\\"Arrhythmia\\\",\\n \\\"Myelofibrosis\\\",\\n \\\"Hepatitis\\\",\\n \\\"Urethral stricture\\\",\\n \\\"Allergy\\\",\\n \\\"Renal atrophy\\\",\\n \\\"Pulmonary bulla\\\",\\n \\\"Chronic colitis\\\",\\n \\\"Neoplasm of the lung\\\",\\n \\\"Cognitive impairment\\\",\\n \\\"Hernia\\\",\\n \\\"Sepsis\\\",\\n \\\"Skin ulcer\\\",\\n \\\"Left ventricular dilatation\\\",\\n \\\"colorectal adenoma\\\",\\n \\\"airway hyperresponsiveness\\\",\\n \\\"skin aging\\\",\\n \\\"adolescent idiopathic scoliosis\\\",\\n \\\"triple-negative breast cancer\\\",\\n \\\"bile duct carcinoma\\\",\\n \\\"glioma\\\",\\n \\\"gamma chain deficiency\\\",\\n \\\"seborrheic keratosis\\\",\\n \\\"rectal adenocarcinoma\\\",\\n \\\"intracerebral hemorrhage\\\",\\n \\\"smoking initiation\\\",\\n \\\"Staphylococcus aureus infection\\\",\\n \\\"rheumatic disease\\\",\\n \\\"lupus nephritis\\\",\\n \\\"pulse pressure measurement\\\",\\n \\\"neurodegenerative disease\\\",\\n \\\"retinal detachment\\\",\\n \\\"Autoimmune Hepatitis\\\",\\n \\\"non-high density lipoprotein cholesterol measurement\\\",\\n \\\"brain disease\\\",\\n \\\"aortic disease\\\",\\n \\\"neonatal abstinence syndrome\\\",\\n \\\"allergic rhinitis\\\",\\n \\\"esophageal squamous cell carcinoma\\\",\\n \\\"non-Hodgkins lymphoma\\\",\\n \\\"breast ductal adenocarcinoma\\\",\\n \\\"systolic blood pressure\\\",\\n \\\"diastolic blood pressure\\\",\\n \\\"pulmonary artery enlargement\\\",\\n \\\"laryngeal squamous cell carcinoma\\\",\\n \\\"cystadenocarcinoma\\\",\\n \\\"ovarian mucinous adenocarcinoma\\\",\\n \\\"smoking status measurement\\\",\\n \\\"bladder transitional cell carcinoma\\\",\\n \\\"brain glioblastoma\\\",\\n \\\"cerebral amyloid angiopathy\\\",\\n \\\"autoimmune thyroid disease\\\",\\n \\\"stricture\\\",\\n \\\"head and neck malignant neoplasia\\\",\\n \\\"urgency urinary incontinence\\\",\\n \\\"fibrosis\\\",\\n \\\"diastolic blood pressure change measurement\\\",\\n \\\"drug use measurement\\\",\\n \\\"allergic conjunctivitis\\\",\\n \\\"aortic valve insufficiency\\\",\\n \\\"Balkan nephropathy\\\",\\n \\\"bronchiolitis obliterans\\\",\\n \\\"congenital rubella\\\",\\n \\\"coronavirus infectious disease\\\",\\n \\\"echinococcosis\\\",\\n \\\"endodermal sinus tumor\\\",\\n \\\"Gerstmann syndrome\\\",\\n \\\"Guillain-Barre syndrome\\\",\\n \\\"influenza\\\",\\n \\\"intestinal cancer\\\",\\n \\\"legionellosis\\\",\\n \\\"lymphatic system disease\\\",\\n \\\"male reproductive organ cancer\\\",\\n \\\"aneurysm-osteoarthritis syndrome\\\",\\n \\\"autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome\\\",\\n \\\"hyperuricemic nephropathy, familial juvenile type 3\\\",\\n \\\"graft versus host disease\\\",\\n \\\"autoimmune lymphoproliferative syndrome type 4\\\",\\n \\\"combined immunodeficiency due to LRBA deficiency\\\",\\n \\\"adenine phosphoribosyltransferase deficiency\\\",\\n \\\"karyomegalic interstitial nephritis\\\",\\n \\\"dyskeratosis congenita, autosomal recessive 5\\\",\\n \\\"TCR-alpha-beta-positive T-cell deficiency\\\",\\n \\\"severe combined immunodeficiency due to IKK2 deficiency\\\",\\n \\\"immunodeficiency 18\\\",\\n \\\"immunodeficiency 23\\\",\\n \\\"severe combined immunodeficiency due to CTPS1 deficiency\\\",\\n \\\"severe neurodegenerative syndrome with lipodystrophy\\\",\\n \\\"periodic fever-infantile enterocolitis-autoinflammatory syndrome\\\",\\n \\\"immunodeficiency 37\\\",\\n \\\"chronic atrial and intestinal dysrhythmia\\\",\\n \\\"DOCK2 deficiency\\\",\\n \\\"DDX41-related hematologic malignancy predisposition syndrome\\\",\\n \\\"fibrochondrogenesis 2\\\",\\n \\\"C3 glomerulonephritis\\\",\\n \\\"agammaglobulinemia 7, autosomal recessive\\\",\\n \\\"autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency\\\",\\n \\\"infantile-onset periodic fever-panniculitis-dermatosis syndrome\\\",\\n \\\"lung disease, immunodeficiency, and chromosome breakage syndrome;\\\",\\n \\\"neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade\\\",\\n \\\"chronic diarrhea due to glucoamylase deficiency\\\",\\n \\\"Bardet-Biedl syndrome\\\",\\n \\\"familial pancreatic carcinoma\\\",\\n \\\"nasopharyngeal carcinoma\\\",\\n \\\"craniosynostosis\\\",\\n \\\"keratoconus\\\",\\n \\\"common variable immunodeficiency\\\",\\n \\\"hyperplastic polyposis syndrome\\\",\\n \\\"dentin dysplasia\\\",\\n \\\"T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency\\\",\\n \\\"early myoclonic encephalopathy\\\",\\n \\\"laryngotracheoesophageal cleft\\\",\\n \\\"cleft palate\\\",\\n \\\"qualitative or quantitative defects of dysferlin\\\",\\n \\\"holoprosencephaly\\\",\\n \\\"attenuated familial adenomatous polyposis\\\",\\n \\\"isolated agammaglobulinemia\\\",\\n \\\"pachyonychia congenita\\\",\\n \\\"familial hyperaldosteronism\\\",\\n \\\"hypohidrotic ectodermal dysplasia\\\",\\n \\\"primary ciliary dyskinesia\\\",\\n \\\"APC-related attenuated familial adenomatous polyposis\\\",\\n \\\"meningioma\\\",\\n \\\"multiple epiphyseal dysplasia\\\",\\n \\\"hemangioblastoma\\\",\\n \\\"Moyamoya disease\\\",\\n \\\"thanatophoric dysplasia\\\",\\n \\\"idiopathic pulmonary arterial hypertension\\\",\\n \\\"IgG4-related disease\\\",\\n \\\"juvenile polyposis syndrome\\\",\\n \\\"pituitary tumor\\\",\\n \\\"ameloblastoma\\\",\\n \\\"exstrophy-epispadias complex\\\",\\n \\\"autoimmune lymphoproliferative syndrome\\\",\\n \\\"syringomyelia\\\",\\n \\\"selective IgM deficiency\\\",\\n \\\"persistent truncus arteriosus\\\",\\n \\\"colorectal adenocarcinoma\\\",\\n \\\"congestive heart failure\\\",\\n \\\"Crohn's disease\\\",\\n \\\"cutaneous melanoma\\\",\\n \\\"diabetes mellitus\\\",\\n \\\"diabetic nephropathy\\\",\\n \\\"diffuse gastric adenocarcinoma\\\",\\n \\\"diffuse large B-cell lymphoma\\\",\\n \\\"breast ductal carcinoma in situ\\\",\\n \\\"embryonal rhabdomyosarcoma\\\",\\n \\\"emphysema\\\",\\n \\\"epilepsy\\\",\\n \\\"fetal growth restriction\\\",\\n \\\"ganglioneuroma\\\",\\n \\\"gastric adenocarcinoma\\\",\\n \\\"esophageal adenocarcinoma\\\",\\n \\\"gastric intestinal type adenocarcinoma\\\",\\n \\\"glioblastoma multiforme\\\",\\n \\\"hypertension\\\",\\n \\\"hypertrophic cardiomyopathy\\\",\\n \\\"immune system disease\\\",\\n \\\"infection\\\",\\n \\\"infertility\\\",\\n \\\"injury\\\",\\n \\\"insulinoma\\\",\\n \\\"intracranial hemorrhage\\\",\\n \\\"ischemia\\\",\\n \\\"leukemia\\\",\\n \\\"lung adenocarcinoma\\\",\\n \\\"lymphoma\\\",\\n \\\"mesothelioma\\\",\\n \\\"metabolic disease\\\",\\n \\\"myocardial infarction\\\",\\n \\\"neoplasm\\\",\\n \\\"nervous system disease\\\",\\n \\\"neuroblastoma\\\",\\n \\\"oligodendroglioma\\\",\\n \\\"osteosarcoma\\\",\\n \\\"tuberculosis\\\",\\n \\\"glioblastoma\\\",\\n \\\"chronic granulomatous disease\\\",\\n \\\"liver mesenchymal hamartoma\\\",\\n \\\"activated PI3K-delta syndrome\\\",\\n \\\"carcinoma of liver and intrahepatic biliary tract\\\",\\n \\\"cutaneous polyarteritis nodosa\\\",\\n \\\"hereditary nonpolyposis colon cancer\\\",\\n \\\"Polymerase proofreading-related adenomatous polyposis\\\",\\n \\\"Zika virus infectious disease\\\",\\n \\\"regressive spondylometaphyseal dysplasia\\\",\\n \\\"Jeune syndrome\\\",\\n \\\"Li-Fraumeni syndrome\\\",\\n \\\"posterior cortical atrophy\\\",\\n \\\"22q11.2 deletion syndrome\\\",\\n \\\"Loeys-Dietz syndrome\\\",\\n \\\"congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization\\\",\\n \\\"intrahepatic cholestasis\\\",\\n \\\"bronchopulmonary dysplasia\\\",\\n \\\"Hirschsprung disease\\\",\\n \\\"mucinous adenocarcinoma of the appendix\\\",\\n \\\"Lhermitte-Duclos disease\\\",\\n \\\"sarcoidosis\\\",\\n \\\"peeling skin syndrome\\\",\\n \\\"Fanconi anemia\\\",\\n \\\"dysspondyloenchondromatosis\\\",\\n \\\"adult T-cell leukemia/lymphoma\\\",\\n \\\"extranodal nasal NK/T cell lymphoma\\\",\\n \\\"Turner syndrome\\\",\\n \\\"acute liver failure\\\",\\n \\\"discoid lupus erythematosus\\\",\\n \\\"familial thoracic aortic aneurysm and aortic dissection\\\",\\n \\\"renal hypoplasia\\\",\\n \\\"renal dysplasia\\\",\\n \\\"spondyloepiphyseal dysplasia tarda\\\",\\n \\\"ulnar hemimelia\\\",\\n \\\"radial hemimelia\\\",\\n \\\"growth hormone-producing pituitary gland neoplasm\\\",\\n \\\"encephalitis\\\",\\n \\\"Ehlers-Danlos syndrome\\\",\\n \\\"muscular dystrophy\\\",\\n \\\"autosomal dominant cerebellar ataxia\\\",\\n \\\"precursor B-cell acute lymphoblastic leukemia\\\",\\n \\\"chronic graft versus host disease\\\",\\n \\\"superficial spreading melanoma\\\",\\n \\\"renal pelvis/ureter urothelial carcinoma\\\",\\n \\\"tubulointerstitial kidney disease, autosomal dominant, 2\\\",\\n \\\"lung neoplasm\\\",\\n \\\"intestinal neoplasm\\\",\\n \\\"prostate neoplasm\\\",\\n \\\"mucoepidermoid carcinoma of parotid gland\\\",\\n \\\"neoplasm of esophagus\\\",\\n \\\"tumor of parathyroid gland\\\",\\n \\\"polyp of colon\\\",\\n \\\"low grade glioma\\\",\\n \\\"coronary atherosclerosis\\\",\\n \\\"gram-negative bacterial infections\\\",\\n \\\"sexually transmitted disease\\\",\\n \\\"radiculitis\\\",\\n \\\"viral myocarditis\\\",\\n \\\"lip and oral cavity carcinoma\\\",\\n \\\"immunodeficiency 14b, autosomal recessive\\\",\\n \\\"corneal infection\\\",\\n \\\"pseudoxanthoma elasticum (inherited or acquired)\\\",\\n \\\"respiratory tract infectious disorder\\\",\\n \\\"chondrogenic neoplasm\\\",\\n \\\"squamous cell intraepithelial neoplasia\\\",\\n \\\"liver and intrahepatic bile duct neoplasm\\\",\\n \\\"hypertensive nephropathy\\\",\\n \\\"myocardial disorder\\\",\\n \\\"tubular adenoma\\\",\\n \\\"synucleinopathy\\\",\\n \\\"pulmonary sarcoidosis\\\",\\n \\\"gonorrhea\\\",\\n \\\"chronic lymphocytic leukemia\\\",\\n \\\"neoplasm of mature B-cells\\\",\\n \\\"gastric carcinoma\\\",\\n \\\"head and neck squamous cell carcinoma\\\",\\n \\\"hepatocellular carcinoma\\\",\\n \\\"metastatic prostate cancer\\\",\\n \\\"T-cell acute lymphoblastic leukemia\\\",\\n \\\"unspecified peripheral T-cell lymphoma\\\",\\n \\\"Hodgkins lymphoma\\\",\\n \\\"invasive breast ductal carcinoma\\\",\\n \\\"metabolic syndrome\\\",\\n \\\"oral squamous cell carcinoma\\\",\\n \\\"acute lymphoblastic leukemia\\\",\\n \\\"acute myeloid leukemia\\\",\\n \\\"adenocarcinoma\\\",\\n \\\"adenoma\\\",\\n \\\"adenosquamous lung carcinoma\\\",\\n \\\"adrenal gland pheochromocytoma\\\",\\n \\\"alveolar rhabdomyosarcoma\\\",\\n \\\"aortic stenosis\\\",\\n \\\"astrocytoma\\\",\\n \\\"atopic eczema\\\",\\n \\\"atrial fibrillation\\\",\\n \\\"benign prostatic hyperplasia\\\",\\n \\\"breast adenocarcinoma\\\",\\n \\\"breast carcinoma\\\",\\n \\\"bronchoalveolar adenocarcinoma\\\",\\n \\\"Burkitts lymphoma\\\",\\n \\\"carcinoma\\\",\\n \\\"cardiomyopathy\\\",\\n \\\"cardiovascular disease\\\",\\n \\\"chondrosarcoma\\\",\\n \\\"chronic myelogenous leukemia\\\",\\n \\\"chronic obstructive pulmonary disease\\\",\\n \\\"chronic pancreatitis\\\",\\n \\\"clear cell renal carcinoma\\\",\\n \\\"endometrial carcinoma\\\",\\n \\\"renal fibrosis\\\",\\n \\\"Adenomyosis\\\",\\n \\\"immunoproliferative small intestinal disease\\\",\\n \\\"Posterior Leukoencephalopathy Syndrome\\\",\\n \\\"amyloidosis\\\",\\n \\\"neuroendocrine neoplasm\\\",\\n \\\"Spinal cord injury\\\",\\n \\\"B-cell non-Hodgkins lymphoma\\\",\\n \\\"colon adenocarcinoma\\\",\\n \\\"colon carcinoma\\\",\\n \\\"colorectal carcinoma\\\",\\n \\\"intrahepatic cholangiocarcinoma\\\",\\n \\\"pharyngeal squamous cell carcinoma\\\",\\n \\\"connective tissue disease\\\",\\n \\\"pneumonitis\\\",\\n \\\"Carcinoma, Lewis Lung\\\",\\n \\\"soft tissue sarcoma\\\",\\n \\\"adult onset asthma\\\",\\n \\\"chronic rhinosinusitis with nasal polyps\\\",\\n \\\"chronic rhinosinusitis without nasal polyps\\\",\\n \\\"renal hypertension\\\",\\n \\\"glomerular disease\\\",\\n \\\"nephritis\\\",\\n \\\"positive regulation of ovulation\\\",\\n \\\"Neurogenic bladder\\\",\\n \\\"Inguinal hernia\\\",\\n \\\"Abnormality of the urinary system\\\",\\n \\\"Renal insufficiency\\\",\\n \\\"Glomerular sclerosis\\\",\\n \\\"Glomerulonephritis\\\",\\n \\\"Nephropathy\\\",\\n \\\"Nephrocalcinosis\\\",\\n \\\"Uterine leiomyoma\\\",\\n \\\"Cleft palate\\\",\\n \\\"Retrognathia\\\",\\n \\\"Strabismus\\\",\\n \\\"Cataract\\\",\\n \\\"Proptosis\\\",\\n \\\"Myopia\\\",\\n \\\"Pectus excavatum\\\",\\n \\\"Infertility\\\",\\n \\\"Hematuria\\\",\\n \\\"Diabetes mellitus\\\",\\n \\\"Hyperinsulinemia\\\",\\n \\\"Insulin resistance\\\",\\n \\\"Abnormality of the skeletal system\\\",\\n \\\"Osteopenia\\\",\\n \\\"Osteoporosis\\\",\\n \\\"Jaundice\\\",\\n \\\"Eczematoid dermatitis\\\",\\n \\\"Global developmental delay\\\",\\n \\\"Stroke\\\",\\n \\\"Encephalopathy\\\",\\n \\\"Parkinsonism\\\",\\n \\\"Rheumatoid arthritis\\\",\\n \\\"Cirrhosis\\\",\\n \\\"Hepatic fibrosis\\\",\\n \\\"Cholestasis\\\",\\n \\\"Hepatic steatosis\\\",\\n \\\"Obesity\\\",\\n \\\"ornithine carbamoyltransferase deficiency\\\",\\n \\\"pseudomyxoma peritonei\\\",\\n \\\"silicosis\\\",\\n \\\"spinal stenosis\\\",\\n \\\"BMI-adjusted waist-hip ratio\\\",\\n \\\"BMI-adjusted waist circumference\\\",\\n \\\"body fat percentage\\\",\\n \\\"balding measurement\\\",\\n \\\"liver dysplastic nodule\\\",\\n \\\"wellbeing measurement\\\",\\n \\\"insomnia measurement\\\",\\n \\\"eosinophil percentage of leukocytes\\\",\\n \\\"eosinophil percentage of granulocytes\\\",\\n \\\"BMI-adjusted hip circumference\\\",\\n \\\"calf circumference measurement\\\",\\n \\\"chronic hepatitis\\\",\\n \\\"dysplasia\\\",\\n \\\"interstitial cystitis\\\",\\n \\\"lobular breast carcinoma\\\",\\n \\\"nodular melanoma\\\",\\n \\\"non-functioning pituitary adenoma\\\",\\n \\\"oral lichen planus\\\",\\n \\\"rhinitis\\\",\\n \\\"small cell carcinoma\\\",\\n \\\"status epilepticus\\\",\\n \\\"steatosis\\\",\\n \\\"urothelial carcinoma\\\",\\n \\\"Hepatobiliary Neoplasm\\\",\\n \\\"acute myocardial infarction\\\",\\n \\\"peritonitis\\\",\\n \\\"pemphigus foliaceus\\\",\\n \\\"paraneoplastic pemphigus\\\",\\n \\\"cystic kidney disease\\\",\\n \\\"ovarian dysfunction\\\",\\n \\\"Arteritis\\\",\\n \\\"Polyarteritis Nodosa\\\",\\n \\\"arteriosclerosis\\\",\\n \\\"idiopathic dilated cardiomyopathy\\\",\\n \\\"hyperuricemia\\\",\\n \\\"female reproductive endometrioid cancer\\\",\\n \\\"skin carcinoma\\\",\\n \\\"heel bone mineral density\\\",\\n \\\"marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections\\\",\\n \\\"central nervous system disease\\\",\\n \\\"sum of eosinophil and basophil counts\\\",\\n \\\"lower respiratory tract disease\\\",\\n \\\"pulmonary fibrosis\\\",\\n \\\"infarction\\\",\\n \\\"corneal disease\\\",\\n \\\"vertebral joint disease\\\",\\n \\\"aortic valve disease\\\",\\n \\\"cervical disc degenerative disorder\\\",\\n \\\"hemorrhoid\\\",\\n \\\"mitral valve disease\\\",\\n \\\"feeling nervous measurement\\\",\\n \\\"stomach disease\\\",\\n \\\"myocarditis\\\",\\n \\\"aneurysm\\\",\\n \\\"laryngeal disease\\\",\\n \\\"musculoskeletal system disease\\\",\\n \\\"Gallbladder Adenocarcinoma\\\",\\n \\\"Gallbladder Adenoma\\\",\\n \\\"Gastric Neuroendocrine Tumor G1\\\",\\n \\\"Granular Cell Tumor\\\",\\n \\\"Hepatoblastoma\\\",\\n \\\"HER2 Positive Breast Carcinoma\\\",\\n \\\"Invasive Breast Carcinoma\\\",\\n \\\"Mast Cell Sarcoma\\\",\\n \\\"Nasal Cavity Polyp\\\",\\n \\\"Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation\\\",\\n \\\"Ovarian Endometriosis\\\",\\n \\\"Ovarian Granulosa Cell Tumor\\\",\\n \\\"Peritoneal Multicystic Mesothelioma\\\",\\n \\\"Pituitary Gland Adenoma\\\",\\n \\\"Placental Choriocarcinoma\\\",\\n \\\"Pleural Epithelioid Mesothelioma\\\",\\n \\\"Poorly Differentiated Thyroid Gland Carcinoma\\\",\\n \\\"Rectal Tubular Adenoma\\\",\\n \\\"Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions\\\",\\n \\\"Signet Ring Cell Gastric Adenocarcinoma\\\",\\n \\\"small intestinal adenocarcinoma\\\",\\n \\\"Spinal Chordoma\\\",\\n \\\"Testicular Embryonal Carcinoma\\\",\\n \\\"Thyroid Gland Oncocytic Follicular Carcinoma\\\",\\n \\\"Thyroid Gland Undifferentiated (Anaplastic) Carcinoma\\\",\\n \\\"Uterine Carcinosarcoma\\\",\\n \\\"Vaginal Melanoma\\\",\\n \\\"hamartoma\\\",\\n \\\"acute respiratory distress syndrome\\\",\\n \\\"rectum cancer\\\",\\n \\\"acanthosis nigricans\\\",\\n \\\"cholesteatoma\\\",\\n \\\"Primary Pulmonary Diffuse Large B-Cell Lymphoma\\\",\\n \\\"developmental dysplasia of the hip\\\",\\n \\\"sarcopenia\\\",\\n \\\"mucous membrane pemphigoid\\\",\\n \\\"osteoarthritis, hip\\\",\\n \\\"osteoarthritis, spine\\\",\\n \\\"adrenal cortex carcinoma\\\",\\n \\\"adrenal gland hyperfunction\\\",\\n \\\"alcoholic cardiomyopathy\\\",\\n \\\"aortitis\\\",\\n \\\"atrial heart septal defect\\\",\\n \\\"causalgia\\\",\\n \\\"coronary aneurysm\\\",\\n \\\"diastolic heart failure\\\",\\n \\\"dry eye syndrome\\\",\\n \\\"Helicobacter pylori infectious disease\\\",\\n \\\"inflammatory breast carcinoma\\\",\\n \\\"joint disease\\\",\\n \\\"lipoid nephrosis\\\",\\n \\\"mouth disease\\\",\\n \\\"multiple system atrophy\\\",\\n \\\"myeloid sarcoma\\\",\\n \\\"ocular hypertension\\\",\\n \\\"parathyroid adenoma\\\",\\n \\\"proliferative vitreoretinopathy\\\",\\n \\\"pulmonary edema\\\",\\n \\\"pulpitis\\\",\\n \\\"Raynaud disease\\\",\\n \\\"renovascular hypertension\\\",\\n \\\"rheumatic heart disease\\\",\\n \\\"Schnitzler syndrome\\\",\\n \\\"thromboangiitis obliterans\\\",\\n \\\"ulcerative proctosigmoiditis\\\",\\n \\\"uremia\\\",\\n \\\"non-alcoholic steatohepatitis\\\",\\n \\\"rotator cuff tear\\\",\\n \\\"Anemia, Hemolytic, Autoimmune\\\",\\n \\\"Cardiac Tamponade\\\",\\n \\\"End Stage Liver Disease\\\",\\n \\\"Endometritis\\\",\\n \\\"Escherichia coli Infections\\\",\\n \\\"Genital neoplasm, female\\\",\\n \\\"Heavy Chain Disease\\\",\\n \\\"Hepatopulmonary Syndrome\\\",\\n \\\"Lentivirus Infections\\\",\\n \\\"Myocardial Ischemia\\\",\\n \\\"Periapical Periodontitis\\\",\\n \\\"Peritoneal Fibrosis\\\",\\n \\\"Tularemia\\\",\\n \\\"diabetic cardiomyopathy\\\",\\n \\\"endothelial dysfunction\\\",\\n \\\"gliosarcoma\\\",\\n \\\"Mantle cell lymphoma\\\",\\n \\\"Merkel cell skin cancer\\\",\\n \\\"metastatic colorectal cancer\\\",\\n \\\"enterocolitis\\\",\\n \\\"primary biliary cirrhosis\\\",\\n \\\"abortion\\\",\\n \\\"psoriasis vulgaris\\\",\\n \\\"Autosomal dominant polycystic kidney disease\\\",\\n \\\"osteoporosis-pseudoglioma syndrome\\\",\\n \\\"primary hyperoxaluria type 2\\\",\\n \\\"hyperimmunoglobulinemia D with periodic fever\\\",\\n \\\"autosomal recessive polycystic kidney disease\\\",\\n \\\"Senior-Loken syndrome 1\\\",\\n \\\"reticular dysgenesis\\\",\\n \\\"schneckenbecken dysplasia\\\",\\n \\\"combined immunodeficiency due to ZAP70 deficiency\\\",\\n \\\"familial isolated congenital asplenia\\\",\\n \\\"brachyolmia type 1, Hobaek type\\\",\\n \\\"brachyolmia type 1, toledo type\\\",\\n \\\"spondyloperipheral dysplasia\\\",\\n \\\"thoracomelic dysplasia\\\",\\n \\\"congenital bilateral aplasia of vas deferens from CFTR mutation\\\",\\n \\\"Wilson disease\\\",\\n \\\"X-linked spondyloepimetaphyseal dysplasia\\\",\\n \\\"hypoxanthine guanine phosphoribosyltransferase partial deficiency\\\",\\n \\\"Bruton-type agammaglobulinemia\\\",\\n \\\"X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia\\\",\\n \\\"combined immunodeficiency due to moesin deficiency\\\",\\n \\\"Wiskott-Aldrich syndrome\\\",\\n \\\"Aarskog-Scott syndrome, X-linked\\\",\\n \\\"hyper-IgM syndrome type 1\\\",\\n \\\"Melnick-Needles syndrome\\\",\\n \\\"Bartsocas-Papas syndrome 1\\\",\\n \\\"pulmonary venoocclusive disease\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Irapa type\\\",\\n \\\"SHOX-related short stature\\\",\\n \\\"immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome\\\",\\n \\\"Duchenne muscular dystrophy\\\",\\n \\\"X-linked retinoschisis\\\",\\n \\\"spondyloepiphyseal dysplasia tarda, X-linked\\\",\\n \\\"T-B+ severe combined immunodeficiency due to JAK3 deficiency\\\",\\n \\\"Timothy syndrome\\\",\\n \\\"supranuclear palsy, progressive, 1\\\",\\n \\\"skeletal dysplasia-epilepsy-short stature syndrome\\\",\\n \\\"hereditary mixed polyposis syndrome\\\",\\n \\\"severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive\\\",\\n \\\"Ehlers-Danlos syndrome, musculocontractural type\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Missouri type\\\",\\n \\\"axial spondylometaphyseal dysplasia\\\",\\n \\\"severe combined immunodeficiency due to DCLRE1C deficiency\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Shohat type\\\",\\n \\\"myotonic dystrophy type 2\\\",\\n \\\"radioulnar synostosis-microcephaly-scoliosis syndrome\\\",\\n \\\"spondyloepimetaphyseal dysplasia with multiple dislocations\\\",\\n \\\"Omenn syndrome\\\",\\n \\\"xanthinuria type II\\\",\\n \\\"autoimmune lymphoproliferative syndrome type 2A\\\",\\n \\\"nephronophthisis 3\\\",\\n \\\"pyogenic arthritis-pyoderma gangrenosum-acne syndrome\\\",\\n \\\"hyper-IgM syndrome type 2\\\",\\n \\\"immunodeficiency due to CD25 deficiency\\\",\\n \\\"lymphangioleiomyomatosis\\\",\\n \\\"gastrointestinal stromal tumor\\\",\\n \\\"hyper-IgM syndrome type 3\\\",\\n \\\"multiple epiphyseal dysplasia type 5\\\",\\n \\\"anauxetic dysplasia\\\",\\n \\\"autoimmune lymphoproliferative syndrome type 2B\\\",\\n \\\"Smith-McCort dysplasia 1\\\",\\n \\\"granular corneal dystrophy type II\\\",\\n \\\"acrocapitofemoral dysplasia\\\",\\n \\\"endometrial cancer\\\",\\n \\\"hyper-IgM syndrome type 5\\\",\\n \\\"hyper-IgM syndrome type 4\\\",\\n \\\"neutrophil immunodeficiency syndrome\\\",\\n \\\"familial adenomatous polyposis 2\\\",\\n \\\"spondyloepimetaphyseal dysplasia, matrilin-3 type\\\",\\n \\\"familial avascular necrosis of femoral head\\\",\\n \\\"immunodeficiency 104\\\",\\n \\\"spondylometaphyseal dysplasia, A4 type\\\",\\n \\\"epidermolysis bullosa simplex 7, with nephropathy and deafness\\\",\\n \\\"permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome\\\",\\n \\\"mesoaxial synostotic syndactyly with phalangeal reduction\\\",\\n \\\"hyperinsulinemic hypoglycemia, familial, 4\\\",\\n \\\"Mungan syndrome\\\",\\n \\\"familial cold autoinflammatory syndrome 2\\\",\\n \\\"aortic aneurysm, familial thoracic 6\\\",\\n \\\"hypouricemia, renal, 2\\\",\\n \\\"dopa-responsive dystonia due to sepiapterin reductase deficiency\\\",\\n \\\"combined immunodeficiency due to STIM1 deficiency\\\",\\n \\\"atypical hemolytic-uremic syndrome with MCP/CD46 anomaly\\\",\\n \\\"atypical hemolytic-uremic syndrome with I factor anomaly\\\",\\n \\\"atypical hemolytic-uremic syndrome with B factor anomaly\\\",\\n \\\"atypical hemolytic-uremic syndrome with C3 anomaly\\\",\\n \\\"atypical hemolytic-uremic syndrome with thrombomodulin anomaly\\\",\\n \\\"lymphoproliferative syndrome 1\\\",\\n \\\"purine nucleoside phosphorylase deficiency\\\",\\n \\\"spondylo-megaepiphyseal-metaphyseal dysplasia\\\",\\n \\\"brachydactylous dwarfism, Mseleni type\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Handigodu type\\\",\\n \\\"hemolytic anemia due to glucophosphate isomerase deficiency\\\",\\n \\\"alpha 1-antitrypsin deficiency\\\",\\n \\\"occult macular dystrophy\\\",\\n \\\"papillary thyroid carcinoma\\\",\\n \\\"periodontitis\\\",\\n \\\"polycystic ovary syndrome\\\",\\n \\\"polyp\\\",\\n \\\"preeclampsia\\\",\\n \\\"prostate adenocarcinoma\\\",\\n \\\"psoriasis\\\",\\n \\\"renal cell carcinoma\\\",\\n \\\"respiratory system disease\\\",\\n \\\"sarcoma\\\",\\n \\\"severe acute respiratory syndrome\\\",\\n \\\"Sjogren syndrome\\\",\\n \\\"skin disease\\\",\\n \\\"small cell lung carcinoma\\\",\\n \\\"rheumatoid arthritis\\\",\\n \\\"spindle cell tumor\\\",\\n \\\"spondyloarthropathy\\\",\\n \\\"squamous cell carcinoma\\\",\\n \\\"squamous cell lung carcinoma\\\",\\n \\\"systemic scleroderma\\\",\\n \\\"ulcerative colitis\\\",\\n \\\"uterine fibroid\\\",\\n \\\"melanoma\\\",\\n \\\"malignant peripheral nerve sheath tumor\\\",\\n \\\"viral disease\\\",\\n \\\"HIV infection\\\",\\n \\\"AIDS\\\",\\n \\\"idiopathic pulmonary fibrosis\\\",\\n \\\"malignant pleural mesothelioma\\\",\\n \\\"bacterial disease\\\",\\n \\\"temporal lobe epilepsy\\\",\\n \\\"myositis\\\",\\n \\\"leprosy\\\",\\n \\\"celiac disease\\\",\\n \\\"cervical carcinoma\\\",\\n \\\"cytomegalovirus infection\\\",\\n \\\"Down syndrome\\\",\\n \\\"endometriosis\\\",\\n \\\"experimental autoimmune encephalomyelitis\\\",\\n \\\"parasitic infection\\\",\\n \\\"lung carcinoma\\\",\\n \\\"ovarian carcinoma\\\",\\n \\\"post-traumatic stress disorder\\\",\\n \\\"pulmonary arterial hypertension\\\",\\n \\\"synovial sarcoma\\\",\\n \\\"autosomal dominant polycystic liver disease\\\",\\n \\\"cerebral creatine deficiency syndrome\\\",\\n \\\"arterial disorder\\\",\\n \\\"glomerulosclerosis\\\",\\n \\\"small intestinal neuroendocrine tumor G1\\\",\\n \\\"breast benign neoplasm\\\",\\n \\\"central nervous system primitive neuroectodermal neoplasm\\\",\\n \\\"vertebral column disorder\\\",\\n \\\"cerebral cavernous malformation\\\",\\n \\\"interstitial emphysema\\\",\\n \\\"gastric cancer\\\",\\n \\\"essential hypertension\\\",\\n \\\"hypertensive heart disease\\\",\\n \\\"familial hyperlipidemia\\\",\\n \\\"impaired renal function disease\\\",\\n \\\"myopia\\\",\\n \\\"nephrocalcinosis\\\",\\n \\\"leiomyoma\\\",\\n \\\"prolapse of female genital organ\\\",\\n \\\"brain cancer\\\",\\n \\\"nontoxic goiter\\\",\\n \\\"pure red-cell aplasia\\\",\\n \\\"crescentic glomerulonephritis\\\",\\n \\\"tuberous sclerosis\\\",\\n \\\"depressive disorder\\\",\\n \\\"ventricular septal defect\\\",\\n \\\"pneumothorax\\\",\\n \\\"Richter syndrome\\\",\\n \\\"thyroid cancer\\\",\\n \\\"giant cell tumor\\\",\\n \\\"spondylosis\\\",\\n \\\"papilloma\\\",\\n \\\"kidney cancer\\\",\\n \\\"dermatitis\\\",\\n \\\"prostatic adenoma\\\",\\n \\\"lobular neoplasia\\\",\\n \\\"gingival overgrowth\\\",\\n \\\"papillary adenocarcinoma\\\",\\n \\\"digestive system cancer\\\",\\n \\\"inherited lipid metabolism disorder\\\",\\n \\\"skin squamous cell carcinoma\\\",\\n \\\"teratocarcinoma\\\",\\n \\\"teratoma\\\",\\n \\\"bone inflammation disease\\\",\\n \\\"small cell osteogenic sarcoma\\\",\\n \\\"cerebral infarction\\\",\\n \\\"liver cancer\\\",\\n \\\"uterine cancer\\\",\\n \\\"anal canal adenocarcinoma\\\",\\n \\\"skin cancer\\\",\\n \\\"cerebellar neoplasm\\\",\\n \\\"cervical cancer\\\",\\n \\\"breast angiosarcoma\\\",\\n \\\"bile duct adenocarcinoma\\\",\\n \\\"thoracic cancer\\\",\\n \\\"colonic disorder\\\",\\n \\\"functioning pituitary gland adenoma\\\",\\n \\\"anal canal squamous cell carcinoma\\\",\\n \\\"pancreatic intraductal papillary-mucinous neoplasm\\\",\\n \\\"muscular atrophy\\\",\\n \\\"female breast carcinoma\\\",\\n \\\"retinal degeneration\\\",\\n \\\"MHC class II deficiency 4\\\",\\n \\\"immunodeficiency 122\\\",\\n \\\"inflammation\\\",\\n \\\"circulating fibrinogen levels\\\",\\n \\\"glomerular filtration rate\\\",\\n \\\"fat pad mass\\\",\\n \\\"hip circumference\\\",\\n \\\"bone tissue density\\\",\\n \\\"von Willebrand factor quality\\\",\\n \\\"waist circumference\\\",\\n \\\"age of onset of asthma\\\",\\n \\\"level of serum globulin type protein\\\",\\n \\\"red blood cell density\\\",\\n \\\"serum alanine aminotransferase amount\\\",\\n \\\"heart rate\\\",\\n \\\"age of onset of allergic disease\\\",\\n \\\"brain volume\\\",\\n \\\"serum albumin amount\\\",\\n \\\"serum creatinine amount\\\",\\n \\\"body height\\\",\\n \\\"cyst\\\",\\n \\\"X-linked hyper-IgM syndrome\\\",\\n \\\"Brachydactyly - elbow wrist dysplasia\\\",\\n \\\"Chronic mucocutaneous candidosis\\\",\\n \\\"Desbuquois syndrome\\\",\\n \\\"Ch\\\\u00e9diak-Higashi syndrome\\\",\\n \\\"Recurrent infection due to specific granule deficiency\\\",\\n \\\"Immunodeficiency syndrome with autoimmunity\\\",\\n \\\"Metaphyseal chondrodysplasia, Schmid type\\\",\\n \\\"\\\\u00c5land Islands eye disease\\\",\\n \\\"Ichthyosis - intellectual disability - dwarfism - renal impairment\\\",\\n \\\"Autosomal recessive early-onset inflammatory bowel disease\\\",\\n \\\"X-linked lymphoproliferative disease\\\",\\n \\\"Metaphyseal dysostosis - intellectual disability - conductive deafness\\\",\\n \\\"CHST3-related skeletal dysplasia\\\",\\n \\\"Cyclic neutropenia\\\",\\n \\\"Severe combined immunodeficiency due to adenosine deaminase deficiency\\\",\\n \\\"Aneurysm - osteoarthritis syndrome\\\",\\n \\\"Rare disease with thoracic aortic aneurysm and aortic dissection\\\",\\n \\\"Multiple osteochondromas\\\",\\n \\\"Recurrent infections-myelofibrosis-nephromegaly syndrome\\\",\\n \\\"Acromesomelic dysplasia, Maroteaux type\\\",\\n \\\"Hyperlipoproteinemia type 1\\\",\\n \\\"X-linked agammaglobulinemia\\\",\\n \\\"Familial hemophagocytic lymphohistiocytosis\\\",\\n \\\"Immunodeficiency by defective expression of HLA class 2\\\",\\n \\\"Pyogenic arthritis - pyoderma gangrenosum - acne\\\",\\n \\\"Familial adenomatous polyposis\\\",\\n \\\"Thymic aplasia\\\",\\n \\\"Other metabolic disease\\\",\\n \\\"Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification\\\",\\n \\\"Hypohidrotic ectodermal dysplasia with immunodeficiency\\\",\\n \\\"Leukocyte adhesion deficiency type III\\\",\\n \\\"hematocrit\\\",\\n \\\"C-reactive protein measurement\\\",\\n \\\"glucose measurement\\\",\\n \\\"hemoglobin measurement\\\",\\n \\\"bone quantitative ultrasound measurement\\\",\\n \\\"triglyceride measurement\\\",\\n \\\"alkaline phosphatase measurement\\\",\\n \\\"creatine kinase measurement\\\",\\n \\\"cryptorchidism\\\",\\n \\\"total cholesterol measurement\\\",\\n \\\"gestational diabetes\\\",\\n \\\"low density lipoprotein cholesterol measurement\\\",\\n \\\"lymphocyte count\\\",\\n \\\"acute lung injury\\\",\\n \\\"high density lipoprotein cholesterol measurement\\\",\\n \\\"osteoarthritis, knee\\\",\\n \\\"cystatin C measurement\\\",\\n \\\"factor VII measurement\\\",\\n \\\"IGF-1 measurement\\\",\\n \\\"factor VIII measurement\\\",\\n \\\"white matter integrity\\\",\\n \\\"hip geometry\\\",\\n \\\"factor XI measurement\\\",\\n \\\"intraocular pressure measurement\\\",\\n \\\"sex hormone-binding globulin measurement\\\",\\n \\\"age at menarche\\\",\\n \\\"pelvic organ prolapse\\\",\\n \\\"FEV/FVC ratio\\\",\\n \\\"prion disease\\\",\\n \\\"aspartate aminotransferase measurement\\\",\\n \\\"protein measurement\\\",\\n \\\"neutrophil count\\\",\\n \\\"eosinophil count\\\",\\n \\\"lymph node metastatic carcinoma\\\",\\n \\\"appendicular lean mass\\\",\\n \\\"lumbar disc degeneration\\\",\\n \\\"lean body mass\\\",\\n \\\"type 2 diabetes nephropathy\\\",\\n \\\"autoimmune disease\\\",\\n \\\"congenital heart disease\\\",\\n \\\"central corneal thickness\\\",\\n \\\"cholangiocarcinoma\\\",\\n \\\"reading\\\",\\n \\\"anxiety\\\",\\n \\\"primitive neuroectodermal tumor\\\",\\n \\\"aortic valve calcification\\\",\\n \\\"non-small cell lung adenocarcinoma\\\",\\n \\\"axial length measurement\\\",\\n \\\"contact dermatitis\\\",\\n \\\"vein disorder\\\",\\n \\\"in situ carcinoma\\\",\\n \\\"inborn disorder of amino acid metabolism\\\",\\n \\\"allergic asthma\\\",\\n \\\"fatty liver disease\\\",\\n \\\"alopecia\\\",\\n \\\"hypoplastic left heart syndrome\\\",\\n \\\"Alzheimer disease\\\",\\n \\\"asthma\\\",\\n \\\"urinary bladder carcinoma\\\",\\n \\\"cancer\\\",\\n \\\"glaucoma\\\",\\n \\\"schizophrenia\\\",\\n \\\"upper respiratory tract disorder\\\",\\n \\\"type 1 diabetes mellitus\\\",\\n \\\"type 2 diabetes mellitus\\\",\\n \\\"pulmonary hypertension\\\",\\n \\\"osteoarthritis\\\",\\n \\\"Parkinson disease\\\",\\n \\\"pancreatic ductal adenocarcinoma\\\",\\n \\\"bacterial urinary tract infection\\\",\\n \\\"allergic disease\\\",\\n \\\"multiple sclerosis\\\",\\n \\\"skin basal cell carcinoma\\\",\\n \\\"childhood onset asthma\\\",\\n \\\"colorectal cancer\\\",\\n \\\"Lynch syndrome\\\",\\n \\\"Wilms tumor\\\",\\n \\\"prune belly syndrome\\\",\\n \\\"Adams-Oliver syndrome\\\",\\n \\\"Acropectorovertebral dysplasia\\\",\\n \\\"severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency\\\",\\n \\\"Tietz syndrome\\\",\\n \\\"autosomal dominant Alport syndrome\\\",\\n \\\"Townes-Brocks syndrome\\\",\\n \\\"atelosteogenesis type III\\\",\\n \\\"Osebold-Remondini syndrome\\\",\\n \\\"brachydactyly type C\\\",\\n \\\"autosomal dominant brachyolmia\\\",\\n \\\"Gordon syndrome\\\",\\n \\\"breast cancer\\\",\\n \\\"chondrocalcinosis 2\\\",\\n \\\"congenital contractural arachnodactyly\\\",\\n \\\"fleck corneal dystrophy\\\",\\n \\\"Duane retraction syndrome\\\",\\n \\\"Leri-Weill dyschondrosteosis\\\",\\n \\\"Beckwith-Wiedemann syndrome\\\",\\n \\\"esophageal cancer\\\",\\n \\\"autoinflammatory syndrome, familial, X-linked, Behcet-like 2\\\",\\n \\\"immunodeficiency 98 with autoinflammation, X-linked\\\",\\n \\\"metastatic malignant neoplasm\\\",\\n \\\"granulomatous disease, chronic, autosomal recessive, 5\\\",\\n \\\"hyper-IgE recurrent infection syndrome 5, autosomal recessive\\\",\\n \\\"immunodeficiency 81\\\",\\n \\\"immunodeficiency 82 with systemic inflammation\\\",\\n \\\"inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive\\\",\\n \\\"immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias\\\",\\n \\\"immunodeficiency 75\\\",\\n \\\"immunodeficiency 76\\\",\\n \\\"nephrotic syndrome 16\\\",\\n \\\"immunodeficiency 69\\\",\\n \\\"immunodeficiency 78 with autoimmunity and developmental delay\\\",\\n \\\"immunodeficiency 70\\\",\\n \\\"immunodeficiency 72 with autoinflammation\\\",\\n \\\"immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia\\\",\\n \\\"autoinflammation, immune dysregulation, and eosinophilia\\\",\\n \\\"severe combined immunodeficiency due to CD70 deficiency\\\",\\n \\\"myofibroblastoma\\\",\\n \\\"invasive carcinoma\\\",\\n \\\"adenoviridae infectious disease\\\",\\n \\\"brain injury\\\",\\n \\\"nosocomial infection\\\",\\n \\\"enteritis\\\",\\n \\\"ulcer disease\\\",\\n \\\"radiation pneumonitis\\\",\\n \\\"familial adenomatous polyposis 4\\\",\\n \\\"severe combined immunodeficiency due to LAT deficiency\\\",\\n \\\"desmoplastic melanoma\\\",\\n \\\"myelofibrosis\\\",\\n \\\"salivary duct carcinoma\\\",\\n \\\"oral cavity carcinoma\\\",\\n \\\"rectal carcinoma\\\",\\n \\\"vertebral disorder\\\",\\n \\\"digestive system melanoma\\\",\\n \\\"short-rib thoracic dysplasia 17 with or without polydactyly\\\",\\n \\\"platelet abnormalities with eosinophilia and immune-mediated inflammatory disease\\\",\\n \\\"COVID-19\\\",\\n \\\"liver failure\\\",\\n \\\"COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults\\\",\\n \\\"disease arising from reactivation of latent virus\\\",\\n \\\"Friedreich ataxia\\\",\\n \\\"malignant glioma\\\",\\n \\\"spondyloepimetaphyseal dysplasia\\\",\\n \\\"gastrointestinal defects and immunodeficiency syndrome 1\\\",\\n \\\"immunodeficiency 105\\\",\\n \\\"autoinflammatory disease, X-linked\\\",\\n \\\"autoinflammatory syndrome with immunodeficiency\\\",\\n \\\"achalasia-alacrima syndrome\\\",\\n \\\"choroidal neovascularization\\\",\\n \\\"rhizomelic dysplasia, Ain-Naz type\\\",\\n \\\"autoinflammatory disease, multisystem, with immune dysregulation, X-linked\\\",\\n \\\"hyper-IgE syndrome 6, autosomal dominant, with recurrent infections\\\",\\n \\\"immunodeficiency 113 with autoimmunity and autoinflammation\\\",\\n \\\"immunodeficiency 117\\\",\\n \\\"neutropenia, severe congenital, 11, autosomal dominant\\\",\\n \\\"autoinflammation with episodic fever and immune dysregulation\\\",\\n \\\"immunodeficiency 119\\\",\\n \\\"postmenopausal osteoporosis\\\",\\n \\\"dissection\\\",\\n \\\"uterine neoplasm\\\",\\n \\\"pancreatic neoplasm\\\",\\n \\\"kidney neoplasm\\\",\\n \\\"brain aneurysm\\\",\\n \\\"colitis\\\",\\n \\\"osteoporosis\\\",\\n \\\"chronic kidney disease\\\",\\n \\\"ovarian neoplasm\\\",\\n \\\"acne\\\",\\n \\\"ankylosing spondylitis\\\",\\n \\\"deep vein thrombosis\\\",\\n \\\"angina pectoris\\\",\\n \\\"atherosclerosis\\\",\\n \\\"necrotizing enterocolitis\\\",\\n \\\"gastroesophageal reflux disease\\\",\\n \\\"seasonal allergic rhinitis\\\",\\n \\\"breast neoplasm\\\",\\n \\\"left ventricular hypertrophy\\\",\\n \\\"stomach neoplasm\\\",\\n \\\"obstructive sleep apnea\\\",\\n \\\"relapsing-remitting multiple sclerosis\\\",\\n \\\"angiosarcoma\\\",\\n \\\"colorectal neoplasm\\\",\\n \\\"neuropathy\\\",\\n \\\"open-angle glaucoma\\\",\\n \\\"basal cell carcinoma\\\",\\n \\\"IGA glomerulonephritis\\\",\\n \\\"hepatitis B virus infection\\\",\\n \\\"skin neoplasm\\\",\\n \\\"Vitiligo\\\",\\n \\\"hypospadias\\\",\\n \\\"Keloid\\\",\\n \\\"Abdominal Aortic Aneurysm\\\",\\n \\\"chronic hepatitis C virus infection\\\",\\n \\\"eosinophilic esophagitis\\\",\\n \\\"exfoliation syndrome\\\",\\n \\\"focal segmental glomerulosclerosis\\\",\\n \\\"chronic hepatitis B virus infection\\\",\\n \\\"interstitial lung disease\\\",\\n \\\"mucocutaneous lymph node syndrome\\\",\\n \\\"meningococcal infection\\\",\\n \\\"membranous glomerulonephritis\\\",\\n \\\"nephrotic syndrome\\\",\\n \\\"osteonecrosis\\\",\\n \\\"bone disease\\\",\\n \\\"vascular disease\\\",\\n \\\"peripheral arterial disease\\\",\\n \\\"sclerosing cholangitis\\\",\\n \\\"scoliosis\\\",\\n \\\"brain infarction\\\",\\n \\\"thoracic aortic aneurysm\\\",\\n \\\"ventricular fibrillation\\\",\\n \\\"colonic neoplasm\\\",\\n \\\"erythrocyte count\\\",\\n \\\"platelet count\\\",\\n \\\"vital capacity\\\",\\n \\\"forced expiratory volume\\\",\\n \\\"smoking behavior\\\",\\n \\\"body weight\\\",\\n \\\"body mass index\\\",\\n \\\"body fat distribution\\\",\\n \\\"waist-hip ratio\\\",\\n \\\"corneal topography\\\",\\n \\\"neuroimaging measurement\\\",\\n \\\"metastatic neoplasm\\\",\\n \\\"wheezing\\\",\\n \\\"enthesitis-related juvenile idiopathic arthritis\\\",\\n \\\"Chronic Obstructive Asthma\\\",\\n \\\"carotid atherosclerosis\\\",\\n \\\"pulse wave reflection index measurement\\\",\\n \\\"total hip arthroplasty\\\",\\n \\\"kidney injury\\\",\\n \\\"muscle atrophy\\\",\\n \\\"chromosomal aberration frequency\\\",\\n \\\"bone metastasis\\\",\\n \\\"HMG CoA reductase inhibitor use measurement\\\",\\n \\\"Inhalant adrenergic use measurement\\\",\\n \\\"Glucocorticoid use measurement\\\",\\n \\\"low density lipoprotein triglyceride measurement\\\",\\n \\\"diverticular disease\\\",\\n \\\"corneal resistance factor\\\",\\n \\\"citrate measurement\\\",\\n \\\"cholesteryl ester measurement\\\",\\n \\\"glucuronate measurement\\\",\\n \\\"isocitrate measurement\\\",\\n \\\"atopic asthma\\\",\\n \\\"coinfection\\\",\\n \\\"total joint arthroplasty\\\",\\n \\\"aspartate aminotransferase to alanine aminotransferase ratio\\\",\\n \\\"nephrotoxicity\\\",\\n \\\"inflammatory bowel disease, immunodeficiency, and encephalopathy\\\",\\n \\\"severe malarial anemia\\\",\\n \\\"total knee arthroplasty\\\",\\n \\\"palmitate 16:0 measurement\\\",\\n \\\"sexual dimorphism measurement\\\",\\n \\\"body surface area\\\",\\n \\\"serum lipopolysaccharide activity\\\",\\n \\\"Birt-Hogg-Dube syndrome\\\",\\n \\\"25-hydroxyvitamin D3 measurement\\\",\\n \\\"cecum adenocarcinoma\\\",\\n \\\"chronic rhinosinusitis\\\",\\n \\\"cystitis\\\",\\n \\\"granulosa cell tumor\\\",\\n \\\"ovarian clear cell adenocarcinoma\\\",\\n \\\"pancreatic adenocarcinoma\\\",\\n \\\"pancreatic neuroendocrine tumor\\\",\\n \\\"pulmonary tuberculosis\\\",\\n \\\"tongue squamous cell carcinoma\\\",\\n \\\"nasopharyngeal squamous cell carcinoma\\\",\\n \\\"Acute Leukemia\\\",\\n \\\"Ampulla of Vater Carcinoma\\\",\\n \\\"Appendix Adenocarcinoma\\\",\\n \\\"Atrophy\\\",\\n \\\"Atypical Meningioma\\\",\\n \\\"Bladder Small Cell Neuroendocrine Carcinoma\\\",\\n \\\"Cavernous Hemangioma\\\",\\n \\\"Central Nervous System Lymphoma\\\",\\n \\\"Cervical Adenosquamous Carcinoma\\\",\\n \\\"cervical squamous cell carcinoma\\\",\\n \\\"Colon Dysplasia\\\",\\n \\\"Duodenal Adenocarcinoma\\\",\\n \\\"Endometrial Clear Cell Adenocarcinoma\\\",\\n \\\"Endometrial Endometrioid Adenocarcinoma\\\",\\n \\\"Endometrial Undifferentiated Carcinoma\\\",\\n \\\"Fibroblastic Neoplasm\\\",\\n \\\"hereditary diffuse gastric adenocarcinoma\\\",\\n \\\"Holt-Oram syndrome\\\",\\n \\\"Huntington disease\\\",\\n \\\"nonpapillary renal cell carcinoma\\\",\\n \\\"Pallister-Hall syndrome\\\",\\n \\\"periodic fever, immunodeficiency, and thrombocytopenia syndrome\\\",\\n \\\"platyspondylic dysplasia, Torrance type\\\",\\n \\\"systemic lupus erythematosus\\\",\\n \\\"Marfan syndrome\\\",\\n \\\"melorheostosis\\\",\\n \\\"mesomelic dysplasia, Kantaputra type\\\",\\n \\\"metatropic dysplasia\\\",\\n \\\"Mobius syndrome\\\",\\n \\\"Muir-Torre syndrome\\\",\\n \\\"Cowden syndrome 1\\\",\\n \\\"myotonic dystrophy type 1\\\",\\n \\\"nail-patella syndrome\\\",\\n \\\"autosomal dominant progressive nephropathy with hypertension\\\",\\n \\\"ovarian cancer\\\",\\n \\\"Peyronie disease\\\",\\n \\\"polyostotic fibrous dysplasia\\\",\\n \\\"juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome\\\",\\n \\\"Hutchinson-Gilford progeria syndrome\\\",\\n \\\"familial juvenile hyperuricemic nephropathy type 1\\\",\\n \\\"Peutz-Jeghers syndrome\\\",\\n \\\"prostate cancer\\\",\\n \\\"pseudoachondroplasia\\\",\\n \\\"autosomal dominant distal renal tubular acidosis\\\",\\n \\\"retinoblastoma\\\",\\n \\\"Smith-Magenis syndrome\\\",\\n \\\"spondyloepiphyseal dysplasia tarda, autosomal dominant\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Strudwick type\\\",\\n \\\"spondylometaphyseal dysplasia, Kozlowski type\\\",\\n \\\"spondylometaphyseal dysplasia, Schmidt type\\\",\\n \\\"proximal symphalangism\\\",\\n \\\"syndactyly type 5\\\",\\n \\\"brachydactyly-elbow wrist dysplasia syndrome\\\",\\n \\\"tarsal-carpal coalition syndrome\\\",\\n \\\"thoracolaryngopelvic dysplasia\\\",\\n \\\"tooth and nail syndrome\\\",\\n \\\"volvulus of midgut\\\",\\n \\\"short-limb skeletal dysplasia with severe combined immunodeficiency\\\",\\n \\\"acrocallosal syndrome\\\",\\n \\\"acrodermatitis enteropathica\\\",\\n \\\"acromesomelic dysplasia 2C, Hunter-Thompson type\\\",\\n \\\"agnathia-otocephaly complex\\\",\\n \\\"autosomal recessive Alport syndrome\\\",\\n \\\"amelogenesis imperfecta type 1G\\\",\\n \\\"microphthalmia with limb anomalies\\\",\\n \\\"progressive pseudorheumatoid arthropathy of childhood\\\",\\n \\\"Bloom syndrome\\\",\\n \\\"kyphomelic dysplasia\\\",\\n \\\"lung cancer\\\",\\n \\\"heart defects-limb shortening syndrome\\\",\\n \\\"chordoma\\\",\\n \\\"Juberg-Hayward syndrome\\\",\\n \\\"Costello syndrome\\\",\\n \\\"cystic fibrosis\\\",\\n \\\"hereditary renal hypouricemia\\\",\\n \\\"diastrophic dysplasia\\\",\\n \\\"Dyggve-Melchior-Clausen disease\\\",\\n \\\"Ehlers-Danlos syndrome, dermatosparaxis type\\\",\\n \\\"multiple epiphyseal dysplasia type 4\\\",\\n \\\"classic Hodgkin lymphoma\\\",\\n \\\"immunodeficiency, common variable, 2\\\",\\n \\\"ichthyosis-intellectual disability-dwarfism-renal impairment syndrome\\\",\\n \\\"Nezelof syndrome\\\",\\n \\\"spondylometaphyseal dysplasia, Sedaghatian type\\\",\\n \\\"metaphyseal dysostosis-intellectual disability-conductive deafness syndrome\\\",\\n \\\"Nijmegen breakage syndrome\\\",\\n \\\"Miyoshi myopathy\\\",\\n \\\"carnitine palmitoyl transferase II deficiency, myopathic form\\\",\\n \\\"Schwartz-Jampel syndrome\\\",\\n \\\"Leigh syndrome\\\",\\n \\\"nail-patella-like renal disease\\\",\\n \\\"nephronophthisis 1\\\",\\n \\\"congenital nephrotic syndrome, Finnish type\\\",\\n \\\"multiple myeloma\\\",\\n \\\"cervical adenocarcinoma\\\",\\n \\\"liver disease\\\",\\n \\\"cirrhosis of liver\\\",\\n \\\"lymphoid neoplasm\\\",\\n \\\"coronary artery disease\\\",\\n \\\"prostate carcinoma\\\",\\n \\\"aortic aneurysm\\\",\\n \\\"human papilloma virus infection\\\",\\n \\\"fibrosarcoma\\\",\\n \\\"benign neoplasm\\\",\\n \\\"hypertrophy\\\",\\n \\\"anaplastic astrocytoma\\\",\\n \\\"cardiac hypertrophy\\\",\\n \\\"medical procedure\\\",\\n \\\"AIDS dementia\\\",\\n \\\"juvenile idiopathic arthritis\\\",\\n \\\"insulin resistance\\\",\\n \\\"prostate intraepithelial neoplasia\\\",\\n \\\"septic peritonitis\\\",\\n \\\"vulvar intraepithelial neoplasia\\\",\\n \\\"renal carcinoma\\\",\\n \\\"thyroid carcinoma\\\",\\n \\\"metastatic melanoma\\\",\\n \\\"pancreatic carcinoma\\\",\\n \\\"rotavirus infection\\\",\\n \\\"Cutaneous T-cell lymphoma\\\",\\n \\\"ovarian serous adenocarcinoma\\\",\\n \\\"rhabdomyosarcoma\\\",\\n \\\"medulloblastoma\\\",\\n \\\"muscular disease\\\",\\n \\\"transitional cell carcinoma of kidney\\\",\\n \\\"anaplastic large cell lymphoma\\\",\\n \\\"bacteriemia\\\",\\n \\\"hepatitis C virus infection\\\",\\n \\\"non-small cell lung carcinoma\\\",\\n \\\"kidney disease\\\",\\n \\\"non-alcoholic fatty liver disease\\\",\\n \\\"peripheral neuropathy\\\",\\n \\\"testicular seminoma\\\",\\n \\\"pneumonia\\\",\\n \\\"heart failure\\\",\\n \\\"vitamin D deficiency\\\",\\n \\\"inflammatory bowel disease\\\",\\n \\\"diabetic retinopathy\\\",\\n \\\"heart disease\\\",\\n \\\"psoriatic arthritis\\\",\\n \\\"refractory anemia with ringed sideroblasts\\\",\\n \\\"laryngeal neoplasm\\\",\\n \\\"lung disease\\\",\\n \\\"brain neoplasm\\\",\\n \\\"calcification\\\",\\n \\\"retinopathy\\\",\\n \\\"thyroid neoplasm\\\"\\n ],\\n \\\"tissue_specific_expression\\\": {\\n \\\"breast\\\": 0,\\n \\\"atrium auricular region\\\": 1,\\n \\\"liver\\\": 0,\\n \\\"skeletal muscle tissue\\\": 1,\\n \\\"EBV-transformed lymphocyte\\\": 0,\\n \\\"esophagus mucosa\\\": 1,\\n \\\"macrophage\\\": -1,\\n \\\"adipose tissue\\\": 0,\\n \\\"segmented neutrophil of bone marrow\\\": -1,\\n \\\"CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\": -1,\\n \\\"class switched memory B cell\\\": 0,\\n \\\"CD14-positive, CD16-negative classical monocyte\\\": 3,\\n \\\"Brodmann (1909) area 9\\\": 0,\\n \\\"CD4-positive, alpha-beta thymocyte\\\": 1,\\n \\\"zone of skin\\\": 1,\\n \\\"leukocyte\\\": 0,\\n \\\"nasopharynx\\\": -1,\\n \\\"tonsil\\\": 0,\\n \\\"frontal lobe\\\": 0,\\n \\\"cerebellar hemisphere\\\": -1,\\n \\\"putamen\\\": 0,\\n \\\"hematopoietic stem cell\\\": -1,\\n \\\"effector memory CD4-positive, alpha-beta T cell\\\": 0,\\n \\\"testis\\\": -1,\\n \\\"bronchus\\\": -1,\\n \\\"sigmoid colon\\\": 0,\\n \\\"fallopian tube\\\": 0,\\n \\\"plasma cell\\\": -1,\\n \\\"aorta\\\": 0,\\n \\\"adrenal gland\\\": -1,\\n \\\"kidney\\\": 0,\\n \\\"endometrium\\\": 0,\\n \\\"smooth muscle tissue\\\": 0,\\n \\\"tibial artery\\\": 0,\\n \\\"prefrontal cortex\\\": 0,\\n \\\"CD8-positive, alpha-beta T cell\\\": -1,\\n \\\"vermiform appendix\\\": 0,\\n \\\"lymph node\\\": 0,\\n \\\"duodenum\\\": 0,\\n \\\"mature eosinophil\\\": 0,\\n \\\"prostate gland\\\": 1,\\n \\\"C1 segment of cervical spinal cord\\\": -1,\\n \\\"lung\\\": 0,\\n \\\"inflammatory macrophage\\\": -1,\\n \\\"rectum\\\": 0,\\n \\\"suprapubic skin\\\": 0,\\n \\\"brain\\\": -1,\\n \\\"coronary artery\\\": 0,\\n \\\"parathyroid gland\\\": -1,\\n \\\"Brodmann (1909) area 24\\\": 0,\\n \\\"esophagus muscularis mucosa\\\": 0,\\n \\\"esophagus\\\": 1,\\n \\\"transformed skin fibroblast\\\": 1,\\n \\\"heart muscle\\\": -1,\\n \\\"pancreas\\\": 0,\\n \\\"uterus\\\": 0,\\n \\\"placenta\\\": 0,\\n \\\"seminal vesicle\\\": -1,\\n \\\"hippocampus\\\": -1,\\n \\\"effector memory CD8-positive, alpha-beta T cell\\\": 0,\\n \\\"endothelial cell of umbilical vein (resting)\\\": 0,\\n \\\"minor salivary gland\\\": 0,\\n \\\"endocervix\\\": 1,\\n \\\"central memory CD8-positive, alpha-beta T cell\\\": 0,\\n \\\"CD8-positive, alpha-beta thymocyte\\\": -1,\\n \\\"granulocyte monocyte progenitor cell\\\": -1,\\n \\\"caudate nucleus\\\": 0,\\n \\\"amygdala\\\": 0,\\n \\\"temporal lobe\\\": 0,\\n \\\"substantia nigra\\\": -1,\\n \\\"abdomen\\\": -1,\\n \\\"common lymphoid progenitor\\\": 0,\\n \\\"cerebral cortex\\\": 0,\\n \\\"endothelial cell of umbilical vein (proliferating)\\\": 0,\\n \\\"blood\\\": -1,\\n \\\"nucleus accumbens\\\": 0,\\n \\\"stomach\\\": 0,\\n \\\"oral mucosa\\\": -1,\\n \\\"mature neutrophil\\\": 0,\\n \\\"central memory CD4-positive, alpha-beta T cell\\\": 0,\\n \\\"bone marrow\\\": -1,\\n \\\"gall bladder\\\": 1,\\n \\\"colon\\\": 0,\\n \\\"cytotoxic CD56-dim natural killer cell\\\": -1,\\n \\\"pituitary gland\\\": 0,\\n \\\"transverse colon\\\": 0,\\n \\\"heart left ventricle\\\": 0,\\n \\\"erythroblast\\\": -1,\\n \\\"vagina\\\": 1,\\n \\\"ovary\\\": 1,\\n \\\"megakaryocyte-erythroid progenitor cell\\\": -1,\\n \\\"subcutaneous adipose tissue\\\": 1,\\n \\\"cerebellum\\\": -1,\\n \\\"hypothalamus\\\": -1,\\n \\\"common myeloid progenitor\\\": -1,\\n \\\"hematopoietic multipotent progenitor cell\\\": -1,\\n \\\"alternatively activated macrophage\\\": -1,\\n \\\"thyroid gland\\\": 1,\\n \\\"lower leg skin\\\": 0,\\n \\\"epididymis\\\": -1,\\n \\\"spleen\\\": 0,\\n \\\"esophagogastric junction\\\": 0,\\n \\\"greater omentum\\\": 1,\\n \\\"memory B cell\\\": 0,\\n \\\"hippocampus proper\\\": -1,\\n \\\"CD4-positive, alpha-beta T cell\\\": -1,\\n \\\"small intestine\\\": 1,\\n \\\"conventional dendritic cell\\\": -1,\\n \\\"cortex of kidney\\\": 0,\\n \\\"small intestine Peyer's patch\\\": 0,\\n \\\"heart\\\": -1,\\n \\\"CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\": -1,\\n \\\"caudate-putamen\\\": -1,\\n \\\"urinary bladder\\\": 1,\\n \\\"ectocervix\\\": 1,\\n \\\"regulatory T cell\\\": -1,\\n \\\"CD38-negative naive B cell\\\": 1,\\n \\\"saliva-secreting gland\\\": 0,\\n \\\"neutrophilic metamyelocyte\\\": -1,\\n \\\"tibial nerve\\\": 0\\n },\\n \\\"is_essential\\\": false,\\n \\\"genetic_constraint\\\": {\\n \\\"syn\\\": -0.12650999426841736,\\n \\\"mis\\\": 4.360300064086914,\\n \\\"lof\\\": 0.9999799728393555\\n },\\n \\\"pharmacovigilance\\\": []\\n },\\n \\\"transcriptome\\\": {\\n \\\"transcripts\\\": {},\\n \\\"isoforms\\\": {\\n \\\"general_localization\\\": {\\n \\\"name\\\": \\\"general_localization\\\",\\n \\\"aliases\\\": [],\\n \\\"status\\\": null,\\n \\\"locations\\\": [\\n \\\"Cytoplasm\\\",\\n \\\"Nucleus\\\"\\n ],\\n \\\"notes\\\": [\\n \\\"Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)\\\"\\n ]\\n }\\n },\\n \\\"avg_exons_per_transcript\\\": null,\\n \\\"transcript_count\\\": 0,\\n \\\"total_exon_count\\\": null,\\n \\\"median_transcript_span_bp\\\": null,\\n \\\"max_transcript_span_bp\\\": null\\n },\\n \\\"gwas_profile\\\": null,\\n \\\"variants\\\": {},\\n \\\"traits\\\": [],\\n \\\"binding_peaks\\\": {},\\n \\\"mirna_targets\\\": {},\\n \\\"alliancegenome_info\\\": [],\\n \\\"viral_interactions\\\": [],\\n \\\"text_summaries_from_tools\\\": [\\n \\\"*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0\\\",\\n \\\"*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.\\\",\\n \\\"*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00\\\",\\n \\\"*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.\\\",\\n \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\",\\n \\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.\\\",\\n \\\"*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Ch\\\\u00e9diak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, \\\\u00c5land Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555\\\",\\n \\\"*GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\\\"\\n ],\\n \\\"tools_run\\\": [\\n \\\"EntityExtraction\\\",\\n \\\"MSigDB\\\",\\n \\\"uniprot_entry\\\",\\n \\\"BioGRID\\\",\\n \\\"OpenTargets\\\",\\n \\\"reactome_pathways\\\",\\n \\\"humanbase_predictions\\\"\\n ]\\n }\\n },\\n \\\"variant_entities\\\": {},\\n \\\"drug_entities\\\": {},\\n \\\"context_block\\\": \\\"\\\",\\n \\\"llm_json\\\": {\\n \\\"answer_with_proofs\\\": [\\n [\\n \\\"NONE\\\",\\n \\\"# Druggability Comparison: SMAD2 vs SMAD3\\\\n\\\\n## Direct Druggability Evidence\\\\n\\\\n### SMAD2\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"No ChEMBL druggability data found for SMAD2\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", indicating a lack of validated small molecule inhibitors or modulators in the ChEMBL database.\\\\n\\\\n### SMAD3\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes - Bioactivity values are normalized to nM and aggregated per compound. - Only positive numeric IC50 / Ki / EC50 values with molar units were considered. - Reported values are the lowest (strongest) potency observed per assay type. - pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\\\\"@GENE: SMAD3 [chars 10810\\\\u201312606] [doc 1]\\\",\\n \\\"SMAD3 has documented bioactivity evidence with 25 compounds showing IC50 values ranging from 38.00 nM to 9894.00 nM, with the most potent compounds being CHEMBL601757 (IC50=38.00 nM, pChEMBL=7.42) and CHEMBL1334062 (IC50=39.00 nM, pChEMBL=7.41)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\". \\\"\\n ],\\n [\\n \\\"\\\\\\\"*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes - Bioactivity values are normalized to nM and aggregated per compound.\\\\\\\"@GENE: SMAD3 [chars 10810\\\\u201312375] [doc 1]\\\",\\n \\\"Notable compounds include CHEMBL6246 (ELLAGIC ACID) with IC50=142.00 nM (pChEMBL=6.85)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Key Finding:** SMAD3 demonstrates significantly better druggability with validated small molecule inhibitors, while SMAD2 lacks such evidence.\\\\n\\\\n---\\\\n\\\\n## Structural Features Relevant to Druggability\\\\n\\\\n### Cysteine Residues (Potential Covalent Drug Targets)\\\\n\\\\n**SMAD2:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"Has 14 detected cysteines, with 2 ligandable cysteines (Q15796_C74, Q15796_C81), 3 binding-site cysteines, and 2 near binding-site cysteines\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\\\\\"@GENE: SMAD3 [chars 0\\\\u20139580] [doc 1]\\\",\\n \\\"Has only 5 detected cysteines, with 0 ligandable cysteines, though 3 are binding-site cysteines\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Implication:** SMAD2's ligandable cysteines (C74 and C81) represent potential sites for covalent inhibitor development, offering a druggability advantage over SMAD3 for this approach.\\\\n\\\\n### Protein Disorder and Binding Regions\\\\n\\\\n**SMAD2:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"Shows 22.7% disordered regions with 3 disordered regions (longest=68 residues) and 14.1% high MoRF propensity (longest segment=66 residues)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\\\\\"@GENE: SMAD3 [chars 0\\\\u20139580] [doc 1]\\\",\\n \\\"Shows 22.6% disordered regions with 4 disordered regions (longest=67 residues) and 13.9% high MoRF propensity (longest segment=59 residues)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Implication:** Both proteins have similar disorder profiles, suggesting comparable challenges for traditional small molecule binding but potential opportunities for targeting protein-protein interactions through MoRF regions.\\\\n\\\\n### Druggable Pockets\\\\n\\\\n**SMAD2:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"FPocket scores range from 0.0 to 0.713 (avg=0.037)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", with the maximum suggesting at least one potentially druggable pocket.\\\\n\\\\n**SMAD3:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\\\\\"@GENE: SMAD3 [chars 0\\\\u20139580] [doc 1]\\\",\\n \\\"FPocket scores range from 0.0 to 0.136 (avg=0.010)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", indicating lower overall pocket druggability.\\\\n\\\\n---\\\\n\\\\n## Targeting Strategies\\\\n\\\\n### 1. Direct Small Molecule Inhibition\\\\n\\\\n**Current Status:**\\\\n- **SMAD3:** Validated approach with nanomolar inhibitors available\\\\n- **SMAD2:** No validated small molecules reported\\\\n\\\\n**Challenges:**\\\\n- Both proteins function as transcription factors, traditionally considered \\\\\\\"undruggable\\\\\\\"\\\\n- High structural similarity between SMAD2 and SMAD3 may complicate selectivity\\\\n\\\\n### 2. Protein-Protein Interaction (PPI) Disruption\\\\n\\\\nBoth proteins form critical complexes:\\\\n\\\\n**SMAD2 interactions:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"Forms heteromeric SMAD protein complexes and interacts with SMAD3, SMAD4, and numerous co-factors including CREBBP, EP300, SKI, SKIL\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**SMAD3 interactions:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\\\\\"@GENE: SMAD3 [chars 0\\\\u20139580] [doc 1]\\\",\\n \\\"Interacts with SMAD2, SMAD4, and similar co-factors, with documented co-crystal structures with SMAD3, SMAD4, and ZFYVE9\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Targeting opportunities:**\\\\n- SMAD2/3-SMAD4 heterotrimer formation\\\\n- Interactions with transcriptional co-activators (CREBBP, EP300)\\\\n- Interactions with inhibitory proteins (SKI, SKIL)\\\\n\\\\n### 3. Covalent Inhibitor Development\\\\n\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"SMAD2's two ligandable cysteines (C74, C81) near binding sites\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\" represent attractive targets for covalent inhibitors, potentially offering:\\\\n- Improved selectivity over SMAD3\\\\n- Enhanced potency through irreversible binding\\\\n- Longer duration of action\\\\n\\\\n### 4. Targeting Post-Translational Modifications\\\\n\\\\nBoth proteins undergo extensive regulation:\\\\n\\\\n**SMAD2:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"Participates in pathways including \\\\\\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\\\\\" and \\\\\\\"Post-translational protein modification\\\\\\\"\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\\\\\"@GENE: SMAD3 [chars 0\\\\u20139580] [doc 1]\\\",\\n \\\"Shows biochemical activity with multiple kinases (CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1) and deubiquitinases (OTUB1, USP15, USP7)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Targeting strategies:**\\\\n- Inhibit activating kinases (TGFBR1)\\\\n- Inhibit CDKs that phosphorylate linker regions\\\\n- Target E3 ubiquitin ligases (SMURF1, SMURF2, WWP2)\\\\n- Inhibit deubiquitinases to promote degradation\\\\n\\\\n### 5. Targeted Protein Degradation (PROTACs/Molecular Glues)\\\\n\\\\n**Advantages:**\\\\n- Circumvents need for traditional binding pockets\\\\n- Can achieve selectivity through E3 ligase recruitment\\\\n- Particularly attractive for SMAD2 given lack of direct inhibitors\\\\n\\\\n**Feasibility:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"SMAD2 interacts with multiple E3 ligases including SMURF2, WWP2, ITCH, NEDD4, NEDD4L\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", and \\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\\\\\"@GENE: SMAD3 [chars 0\\\\u20139580] [doc 1]\\\",\\n \\\"SMAD3 shows similar interactions with NEDD4, NEDD4L, SMURF1, SMURF2, WWP2\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", providing natural degradation pathways to exploit.\\\\n\\\\n---\\\\n\\\\n## Existing Therapeutic Approaches\\\\n\\\\n### Indirect Targeting via TGF-\\\\u03b2 Pathway\\\\n\\\\nBoth proteins are downstream of TGF-\\\\u03b2 receptor signaling:\\\\n\\\\n**SMAD2:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"Participates in \\\\\\\"TGF-beta receptor signaling activates SMADs\\\\\\\" and \\\\\\\"Signaling by TGF-beta Receptor Complex\\\\\\\"\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\\\\\"@GENE: SMAD3 [chars 0\\\\u20139580] [doc 1]\\\",\\n \\\"Similarly involved in TGF-\\\\u03b2 receptor signaling pathways\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Clinical relevance:**\\\\n- TGF-\\\\u03b2 receptor inhibitors (e.g., galunisertib) indirectly block SMAD2/3 activation\\\\n- This approach affects both proteins simultaneously, limiting selectivity\\\\n\\\\n---\\\\n\\\\n## Disease Context and Therapeutic Potential\\\\n\\\\n### SMAD2 Disease Associations\\\\n\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Ch\\\\u00e9diak-Higashi syndrome, \\\\u00c5land Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent M\\\\u00fcllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm.\\\\\\\"@GENE: SMAD2 [chars 19631\\\\u201339230] [doc 0]\\\",\\n \\\"SMAD2 is associated with Loeys-Dietz syndrome 6, congenital heart defects, multiple types, 8, with or without heterotaxy, and numerous cancers including colorectal adenocarcinoma, glioblastoma, and breast cancer\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n### SMAD3 Disease Associations\\\\n\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.\\\\\\\"@GENE: SMAD3 [chars 30923\\\\u201331176] [doc 1]\\\",\\n \\\"SMAD3 is associated with Colorectal cancer and Loeys-Dietz syndrome 3\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", plus \\\"\\n ],\\n [\\n \\\"\\\\\\\"*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infa\\\\u2026\\\\\\\"@GENE: SMAD3 [chars 31176\\\\u201364988] [doc 1]\\\",\\n \\\"extensive associations with cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Therapeutic implications:**\\\\n- **Cancer:** Both are tumor suppressors; inhibition may be contraindicated\\\\n- **Fibrosis:** SMAD3 inhibition shows promise (existing compounds available)\\\\n- **Cardiovascular disease:** Context-dependent; may require selective modulation\\\\n\\\\n---\\\\n\\\\n## Genetic Constraint and Safety Considerations\\\\n\\\\n### Loss-of-Function Tolerance\\\\n\\\\n**SMAD2:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0 *HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall.\\\\\\\"@GENE: SMAD2 [chars 42754\\\\u201343588] [doc 0]\\\",\\n \\\"Genetic constraint score for lof variants: 1.0 (mapped to LOEUF rank, lower = less tolerant)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555 *GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\\\\\\\"@GENE: SMAD3 [chars 68478\\\\u201369820] [doc 1]\\\",\\n \\\"Genetic constraint score for lof variants: 0.9999799728393555\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Interpretation:** Both proteins show high constraint scores (~1.0), indicating that loss-of-function variants are relatively well-tolerated in the population, suggesting potential safety for therapeutic inhibition.\\\\n\\\\n### Essentiality\\\\n\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).\\\\\\\"@GENE: SMAD2 [chars 42599\\\\u201342754] [doc 0]\\\",\\n \\\"SMAD2 is not a core essential gene\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", and \\\"\\n ],\\n [\\n \\\"\\\\\\\"*OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).\\\\\\\"@GENE: SMAD3 [chars 68323\\\\u201368478] [doc 1]\\\",\\n \\\"SMAD3 is not a core essential gene\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", indicating that complete inhibition may be tolerated, though context-dependent effects are likely.\\\\n\\\\n---\\\\n\\\\n## Tissue-Specific Expression Considerations\\\\n\\\\n### SMAD2\\\\n\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}.\\\\\\\"@GENE: SMAD2 [chars 39230\\\\u201342599] [doc 0]\\\",\\n \\\"Shows high tissue-specific expression (z-score \\\\u22652) in: segmented neutrophil of bone marrow (z=4), CD34-negative megakaryocyte cell (z=4), CD8-positive alpha-beta T cell (z=3), CD4-positive alpha-beta T cell (z=3), common lymphoid progenitor (z=3), conventional dendritic cell (z=4), CD4-positive alpha-beta thymocyte (z=5), CD8-positive alpha-beta thymocyte (z=4)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n### SMAD3\\\\n\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}.\\\\\\\"@GENE: SMAD3 [chars 64988\\\\u201368323] [doc 1]\\\",\\n \\\"Shows high tissue-specific expression in: CD14-positive, CD16-negative classical monocyte (z=3)\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", with generally lower tissue specificity than SMAD2.\\\\n\\\\n**Implication:** SMAD2's higher expression in immune cells may complicate systemic inhibition due to immunological effects, while SMAD3's broader expression pattern may present different toxicity concerns.\\\\n\\\\n---\\\\n\\\\n## Challenges and Considerations\\\\n\\\\n### 1. Selectivity Between SMAD2 and SMAD3\\\\n\\\\n- High structural similarity (both R-SMADs)\\\\n- Overlapping functions in TGF-\\\\u03b2 signaling\\\\n- \\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"Both form SMAD2/SMAD3:SMAD4 heterotrimers\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\"\\\\n- Selective inhibition may require exploiting unique interaction surfaces or post-translational modification sites\\\\n\\\\n### 2. Context-Dependent Functions\\\\n\\\\n**Tumor suppressor vs. oncogenic roles:**\\\\n- In early cancer stages: tumor suppressive (inhibition contraindicated)\\\\n- In advanced cancer/metastasis: pro-metastatic (inhibition beneficial)\\\\n- Requires careful patient stratification\\\\n\\\\n### 3. Compensatory Mechanisms\\\\n\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\\\\\"@GENE: SMAD2 [chars 0\\\\u20137603] [doc 0]\\\",\\n \\\"SMAD2 shows phenotypic enhancement with SMAD3\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", and \\\"\\n ],\\n [\\n \\\"\\\\\\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\\\\\"@GENE: SMAD3 [chars 0\\\\u20139580] [doc 1]\\\",\\n \\\"SMAD3 shows phenotypic enhancement with SMAD2\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\", suggesting functional redundancy that may limit single-target efficacy.\\\\n\\\\n### 4. Nuclear-Cytoplasmic Shuttling\\\\n\\\\n**SMAD2:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 .\\\\\\\"@GENE: SMAD2 [chars 18833\\\\u201319228] [doc 0]\\\",\\n \\\"Cytoplasmic and nuclear in the absence of TGF-beta; migrates to nucleus when complexed with SMAD4 or IPO7 upon TGF-beta stimulation; released from complex and exported by RANBP1 upon dephosphorylation by PPM1A\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\"\\n ],\\n [\\n \\\"\\\\\\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 .\\\\\\\"@GENE: SMAD3 [chars 30340\\\\u201330724] [doc 1]\\\",\\n \\\"Shows similar cytoplasmic-nuclear shuttling; migrates to nucleus when complexed with SMAD4; released and exported by RANBP1 through PPM1A action\\\"\\n ],\\n [\\n \\\"NONE\\\",\\n \\\".\\\\n\\\\n**Implication:** Targeting nuclear import/export machinery or phosphatases (PPM1A) could modulate both proteins' activity.\\\\n\\\\n---\\\\n\\\\n## Summary and Recommendations\\\\n\\\\n### Druggability Ranking: SMAD3 > SMAD2\\\\n\\\\n**SMAD3 advantages:**\\\\n1. Validated small molecule inhibitors with nanomolar potency\\\\n2. Established screening assays and chemical starting points\\\\n3. Better characterized in fibrosis (clearer therapeutic indication)\\\\n\\\\n**SMAD2 advantages:**\\\\n1. Ligandable cysteines for covalent inhibitor development\\\\n2. Higher FPocket scores suggesting better pocket druggability\\\\n3. More tissue-restricted expression may reduce off-target effects\\\\n\\\\n### Recommended Targeting Approaches (Priority Order)\\\\n\\\\n1. **SMAD3 direct inhibition** (fibrosis, specific cancers)\\\\n - Build on existing nanomolar inhibitors\\\\n - Optimize for selectivity and pharmacokinetics\\\\n\\\\n2. **SMAD2 covalent inhibition** (cardiovascular, specific cancers)\\\\n - Target ligandable C74 or C81\\\\n - Develop selective covalent warheads\\\\n\\\\n3. **Dual SMAD2/3 PROTACs** (advanced cancers, severe fibrosis)\\\\n - Leverage endogenous E3 ligases (SMURF2, WWP2)\\\\n - Achieve complete pathway blockade\\\\n\\\\n4. **PPI disruption** (SMAD2/3-SMAD4 or co-factor interactions)\\\\n - Target heterotrimer formation\\\\n - Disrupt interactions with CREBBP/EP300\\\\n\\\\n5. **Upstream targeting** (TGF-\\\\u03b2 receptors, activating kinases)\\\\n - Indirect but clinically validated approach\\\\n - Affects both SMAD2 and SMAD3\\\\n\\\\n### Key Unresolved Issues\\\\n\\\\n1. **Selectivity:** Can SMAD2-selective or SMAD3-selective inhibitors be developed given structural similarity?\\\\n2. **Context-dependence:** How to stratify patients for tumor suppressor vs. pro-metastatic contexts?\\\\n3. **Redundancy:** Will single-target inhibition be sufficient or is dual targeting required?\\\\n4. **Biomarkers:** What pharmacodynamic markers can confirm target engagement in vivo?\\\\n5. **Resistance:** Will compensatory upregulation of parallel pathways limit efficacy?\\\\n\\\\n**Possible speculation:**\\\\n\\\\nGiven the existing SMAD3 inhibitors and SMAD2's ligandable cysteines, a rational drug development strategy might involve:\\\\n\\\\n1. **Near-term:** Optimize existing SMAD3 inhibitors for fibrosis indications where the therapeutic rationale is clearest\\\\n2. **Medium-term:** Develop SMAD2-selective covalent inhibitors targeting C74/C81 for cardiovascular indications (Loeys-Dietz syndrome)\\\\n3. **Long-term:** Create bifunctional degraders (PROTACs) for dual SMAD2/3 targeting in advanced cancers where complete pathway blockade is desired\\\\n\\\\nThe higher genetic constraint tolerance and non-essential status of both genes suggest that therapeutic inhibition may be feasible, though careful attention to tissue-specific and context-dependent effects will be critical for safety and efficacy.\\\"\\n ]\\n ],\\n \\\"answer\\\": \\\"# Druggability Comparison: SMAD2 vs SMAD3\\\\n\\\\n## Direct Druggability Evidence\\\\n\\\\n### SMAD2\\\\nNo ChEMBL druggability data found for SMAD2, indicating a lack of validated small molecule inhibitors or modulators in the ChEMBL database.\\\\n\\\\n### SMAD3\\\\nSMAD3 has documented bioactivity evidence with 25 compounds showing IC50 values ranging from 38.00 nM to 9894.00 nM, with the most potent compounds being CHEMBL601757 (IC50=38.00 nM, pChEMBL=7.42) and CHEMBL1334062 (IC50=39.00 nM, pChEMBL=7.41). Notable compounds include CHEMBL6246 (ELLAGIC ACID) with IC50=142.00 nM (pChEMBL=6.85).\\\\n\\\\n**Key Finding:** SMAD3 demonstrates significantly better druggability with validated small molecule inhibitors, while SMAD2 lacks such evidence.\\\\n\\\\n---\\\\n\\\\n## Structural Features Relevant to Druggability\\\\n\\\\n### Cysteine Residues (Potential Covalent Drug Targets)\\\\n\\\\n**SMAD2:**\\\\nHas 14 detected cysteines, with 2 ligandable cysteines (Q15796_C74, Q15796_C81), 3 binding-site cysteines, and 2 near binding-site cysteines.\\\\n\\\\n**SMAD3:**\\\\nHas only 5 detected cysteines, with 0 ligandable cysteines, though 3 are binding-site cysteines.\\\\n\\\\n**Implication:** SMAD2's ligandable cysteines (C74 and C81) represent potential sites for covalent inhibitor development, offering a druggability advantage over SMAD3 for this approach.\\\\n\\\\n### Protein Disorder and Binding Regions\\\\n\\\\n**SMAD2:**\\\\nShows 22.7% disordered regions with 3 disordered regions (longest=68 residues) and 14.1% high MoRF propensity (longest segment=66 residues).\\\\n\\\\n**SMAD3:**\\\\nShows 22.6% disordered regions with 4 disordered regions (longest=67 residues) and 13.9% high MoRF propensity (longest segment=59 residues).\\\\n\\\\n**Implication:** Both proteins have similar disorder profiles, suggesting comparable challenges for traditional small molecule binding but potential opportunities for targeting protein-protein interactions through MoRF regions.\\\\n\\\\n### Druggable Pockets\\\\n\\\\n**SMAD2:**\\\\nFPocket scores range from 0.0 to 0.713 (avg=0.037), with the maximum suggesting at least one potentially druggable pocket.\\\\n\\\\n**SMAD3:**\\\\nFPocket scores range from 0.0 to 0.136 (avg=0.010), indicating lower overall pocket druggability.\\\\n\\\\n---\\\\n\\\\n## Targeting Strategies\\\\n\\\\n### 1. Direct Small Molecule Inhibition\\\\n\\\\n**Current Status:**\\\\n- **SMAD3:** Validated approach with nanomolar inhibitors available\\\\n- **SMAD2:** No validated small molecules reported\\\\n\\\\n**Challenges:**\\\\n- Both proteins function as transcription factors, traditionally considered \\\\\\\"undruggable\\\\\\\"\\\\n- High structural similarity between SMAD2 and SMAD3 may complicate selectivity\\\\n\\\\n### 2. Protein-Protein Interaction (PPI) Disruption\\\\n\\\\nBoth proteins form critical complexes:\\\\n\\\\n**SMAD2 interactions:**\\\\nForms heteromeric SMAD protein complexes and interacts with SMAD3, SMAD4, and numerous co-factors including CREBBP, EP300, SKI, SKIL.\\\\n\\\\n**SMAD3 interactions:**\\\\nInteracts with SMAD2, SMAD4, and similar co-factors, with documented co-crystal structures with SMAD3, SMAD4, and ZFYVE9.\\\\n\\\\n**Targeting opportunities:**\\\\n- SMAD2/3-SMAD4 heterotrimer formation\\\\n- Interactions with transcriptional co-activators (CREBBP, EP300)\\\\n- Interactions with inhibitory proteins (SKI, SKIL)\\\\n\\\\n### 3. Covalent Inhibitor Development\\\\n\\\\nSMAD2's two ligandable cysteines (C74, C81) near binding sites represent attractive targets for covalent inhibitors, potentially offering:\\\\n- Improved selectivity over SMAD3\\\\n- Enhanced potency through irreversible binding\\\\n- Longer duration of action\\\\n\\\\n### 4. Targeting Post-Translational Modifications\\\\n\\\\nBoth proteins undergo extensive regulation:\\\\n\\\\n**SMAD2:**\\\\nParticipates in pathways including \\\\\\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\\\\\" and \\\\\\\"Post-translational protein modification\\\\\\\".\\\\n\\\\n**SMAD3:**\\\\nShows biochemical activity with multiple kinases (CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1) and deubiquitinases (OTUB1, USP15, USP7).\\\\n\\\\n**Targeting strategies:**\\\\n- Inhibit activating kinases (TGFBR1)\\\\n- Inhibit CDKs that phosphorylate linker regions\\\\n- Target E3 ubiquitin ligases (SMURF1, SMURF2, WWP2)\\\\n- Inhibit deubiquitinases to promote degradation\\\\n\\\\n### 5. Targeted Protein Degradation (PROTACs/Molecular Glues)\\\\n\\\\n**Advantages:**\\\\n- Circumvents need for traditional binding pockets\\\\n- Can achieve selectivity through E3 ligase recruitment\\\\n- Particularly attractive for SMAD2 given lack of direct inhibitors\\\\n\\\\n**Feasibility:**\\\\nSMAD2 interacts with multiple E3 ligases including SMURF2, WWP2, ITCH, NEDD4, NEDD4L, and SMAD3 shows similar interactions with NEDD4, NEDD4L, SMURF1, SMURF2, WWP2, providing natural degradation pathways to exploit.\\\\n\\\\n---\\\\n\\\\n## Existing Therapeutic Approaches\\\\n\\\\n### Indirect Targeting via TGF-\\\\u03b2 Pathway\\\\n\\\\nBoth proteins are downstream of TGF-\\\\u03b2 receptor signaling:\\\\n\\\\n**SMAD2:**\\\\nParticipates in \\\\\\\"TGF-beta receptor signaling activates SMADs\\\\\\\" and \\\\\\\"Signaling by TGF-beta Receptor Complex\\\\\\\".\\\\n\\\\n**SMAD3:**\\\\nSimilarly involved in TGF-\\\\u03b2 receptor signaling pathways.\\\\n\\\\n**Clinical relevance:**\\\\n- TGF-\\\\u03b2 receptor inhibitors (e.g., galunisertib) indirectly block SMAD2/3 activation\\\\n- This approach affects both proteins simultaneously, limiting selectivity\\\\n\\\\n---\\\\n\\\\n## Disease Context and Therapeutic Potential\\\\n\\\\n### SMAD2 Disease Associations\\\\n\\\\nSMAD2 is associated with Loeys-Dietz syndrome 6, congenital heart defects, multiple types, 8, with or without heterotaxy, and numerous cancers including colorectal adenocarcinoma, glioblastoma, and breast cancer.\\\\n\\\\n### SMAD3 Disease Associations\\\\n\\\\nSMAD3 is associated with Colorectal cancer and Loeys-Dietz syndrome 3, plus extensive associations with cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers.\\\\n\\\\n**Therapeutic implications:**\\\\n- **Cancer:** Both are tumor suppressors; inhibition may be contraindicated\\\\n- **Fibrosis:** SMAD3 inhibition shows promise (existing compounds available)\\\\n- **Cardiovascular disease:** Context-dependent; may require selective modulation\\\\n\\\\n---\\\\n\\\\n## Genetic Constraint and Safety Considerations\\\\n\\\\n### Loss-of-Function Tolerance\\\\n\\\\n**SMAD2:**\\\\nGenetic constraint score for lof variants: 1.0 (mapped to LOEUF rank, lower = less tolerant).\\\\n\\\\n**SMAD3:**\\\\nGenetic constraint score for lof variants: 0.9999799728393555.\\\\n\\\\n**Interpretation:** Both proteins show high constraint scores (~1.0), indicating that loss-of-function variants are relatively well-tolerated in the population, suggesting potential safety for therapeutic inhibition.\\\\n\\\\n### Essentiality\\\\n\\\\nSMAD2 is not a core essential gene, and SMAD3 is not a core essential gene, indicating that complete inhibition may be tolerated, though context-dependent effects are likely.\\\\n\\\\n---\\\\n\\\\n## Tissue-Specific Expression Considerations\\\\n\\\\n### SMAD2\\\\n\\\\nShows high tissue-specific expression (z-score \\\\u22652) in: segmented neutrophil of bone marrow (z=4), CD34-negative megakaryocyte cell (z=4), CD8-positive alpha-beta T cell (z=3), CD4-positive alpha-beta T cell (z=3), common lymphoid progenitor (z=3), conventional dendritic cell (z=4), CD4-positive alpha-beta thymocyte (z=5), CD8-positive alpha-beta thymocyte (z=4).\\\\n\\\\n### SMAD3\\\\n\\\\nShows high tissue-specific expression in: CD14-positive, CD16-negative classical monocyte (z=3), with generally lower tissue specificity than SMAD2.\\\\n\\\\n**Implication:** SMAD2's higher expression in immune cells may complicate systemic inhibition due to immunological effects, while SMAD3's broader expression pattern may present different toxicity concerns.\\\\n\\\\n---\\\\n\\\\n## Challenges and Considerations\\\\n\\\\n### 1. Selectivity Between SMAD2 and SMAD3\\\\n\\\\n- High structural similarity (both R-SMADs)\\\\n- Overlapping functions in TGF-\\\\u03b2 signaling\\\\n- Both form SMAD2/SMAD3:SMAD4 heterotrimers\\\\n- Selective inhibition may require exploiting unique interaction surfaces or post-translational modification sites\\\\n\\\\n### 2. Context-Dependent Functions\\\\n\\\\n**Tumor suppressor vs. oncogenic roles:**\\\\n- In early cancer stages: tumor suppressive (inhibition contraindicated)\\\\n- In advanced cancer/metastasis: pro-metastatic (inhibition beneficial)\\\\n- Requires careful patient stratification\\\\n\\\\n### 3. Compensatory Mechanisms\\\\n\\\\nSMAD2 shows phenotypic enhancement with SMAD3, and SMAD3 shows phenotypic enhancement with SMAD2, suggesting functional redundancy that may limit single-target efficacy.\\\\n\\\\n### 4. Nuclear-Cytoplasmic Shuttling\\\\n\\\\n**SMAD2:**\\\\nCytoplasmic and nuclear in the absence of TGF-beta; migrates to nucleus when complexed with SMAD4 or IPO7 upon TGF-beta stimulation; released from complex and exported by RANBP1 upon dephosphorylation by PPM1A.\\\\n\\\\n**SMAD3:**\\\\nShows similar cytoplasmic-nuclear shuttling; migrates to nucleus when complexed with SMAD4; released and exported by RANBP1 through PPM1A action.\\\\n\\\\n**Implication:** Targeting nuclear import/export machinery or phosphatases (PPM1A) could modulate both proteins' activity.\\\\n\\\\n---\\\\n\\\\n## Summary and Recommendations\\\\n\\\\n### Druggability Ranking: SMAD3 > SMAD2\\\\n\\\\n**SMAD3 advantages:**\\\\n1. Validated small molecule inhibitors with nanomolar potency\\\\n2. Established screening assays and chemical starting points\\\\n3. Better characterized in fibrosis (clearer therapeutic indication)\\\\n\\\\n**SMAD2 advantages:**\\\\n1. Ligandable cysteines for covalent inhibitor development\\\\n2. Higher FPocket scores suggesting better pocket druggability\\\\n3. More tissue-restricted expression may reduce off-target effects\\\\n\\\\n### Recommended Targeting Approaches (Priority Order)\\\\n\\\\n1. **SMAD3 direct inhibition** (fibrosis, specific cancers)\\\\n - Build on existing nanomolar inhibitors\\\\n - Optimize for selectivity and pharmacokinetics\\\\n\\\\n2. **SMAD2 covalent inhibition** (cardiovascular, specific cancers)\\\\n - Target ligandable C74 or C81\\\\n - Develop selective covalent warheads\\\\n\\\\n3. **Dual SMAD2/3 PROTACs** (advanced cancers, severe fibrosis)\\\\n - Leverage endogenous E3 ligases (SMURF2, WWP2)\\\\n - Achieve complete pathway blockade\\\\n\\\\n4. **PPI disruption** (SMAD2/3-SMAD4 or co-factor interactions)\\\\n - Target heterotrimer formation\\\\n - Disrupt interactions with CREBBP/EP300\\\\n\\\\n5. **Upstream targeting** (TGF-\\\\u03b2 receptors, activating kinases)\\\\n - Indirect but clinically validated approach\\\\n - Affects both SMAD2 and SMAD3\\\\n\\\\n### Key Unresolved Issues\\\\n\\\\n1. **Selectivity:** Can SMAD2-selective or SMAD3-selective inhibitors be developed given structural similarity?\\\\n2. **Context-dependence:** How to stratify patients for tumor suppressor vs. pro-metastatic contexts?\\\\n3. **Redundancy:** Will single-target inhibition be sufficient or is dual targeting required?\\\\n4. **Biomarkers:** What pharmacodynamic markers can confirm target engagement in vivo?\\\\n5. **Resistance:** Will compensatory upregulation of parallel pathways limit efficacy?\\\\n\\\\n**Possible speculation:**\\\\n\\\\nGiven the existing SMAD3 inhibitors and SMAD2's ligandable cysteines, a rational drug development strategy might involve:\\\\n\\\\n1. **Near-term:** Optimize existing SMAD3 inhibitors for fibrosis indications where the therapeutic rationale is clearest\\\\n2. **Medium-term:** Develop SMAD2-selective covalent inhibitors targeting C74/C81 for cardiovascular indications (Loeys-Dietz syndrome)\\\\n3. **Long-term:** Create bifunctional degraders (PROTACs) for dual SMAD2/3 targeting in advanced cancers where complete pathway blockade is desired\\\\n\\\\nThe higher genetic constraint tolerance and non-essential status of both genes suggest that therapeutic inhibition may be feasible, though careful attention to tissue-specific and context-dependent effects will be critical for safety and efficacy.\\\",\\n \\\"manifest\\\": [\\n {\\n \\\"title\\\": \\\"GENE: SMAD2\\\",\\n \\\"kind\\\": \\\"GENE\\\",\\n \\\"key\\\": \\\"SMAD2\\\",\\n \\\"index\\\": 0\\n },\\n {\\n \\\"title\\\": \\\"GENE: SMAD3\\\",\\n \\\"kind\\\": \\\"GENE\\\",\\n \\\"key\\\": \\\"SMAD3\\\",\\n \\\"index\\\": 1\\n }\\n ],\\n \\\"documents\\\": {\\n \\\"0\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. *MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: . *UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) \\\\u2014 TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6. *OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Ch\\\\u00e9diak-Higashi syndrome, \\\\u00c5land Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent M\\\\u00fcllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0 *HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709). *GO: SMAD2 representative GO terms: C:cytoplasm, C:nucleus, C:chromatin, C:heteromeric SMAD protein complex, C:cytosol, C:nucleoplasm, F:DNA-binding transcription factor activity, F:disordered domain specific binding, F:identical protein binding, F:transforming growth factor beta receptor binding, F:cis-regulatory region sequence-specific DNA binding, F:metal ion binding, P:primary miRNA processing, P:lung development, P:endoderm formation, P:odontoblast differentiation, P:determination of left/right asymmetry in lateral mesoderm, P:gastrulation.\\\",\\n \\\"1\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004. *ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation. *MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE. *UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3. *OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Ch\\\\u00e9diak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, \\\\u00c5land Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555 *GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\\\"\\n },\\n \\\"raw_answer\\\": {\\n \\\"id\\\": \\\"msg_01KEjpsA1C66fXQqUJce7MUd\\\",\\n \\\"content\\\": [\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\"# Druggability Comparison: SMAD2 vs SMAD3\\\\n\\\\n## Direct Druggability Evidence\\\\n\\\\n### SMAD2\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"No ChEMBL druggability data found for SMAD2\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", indicating a lack of validated small molecule inhibitors or modulators in the ChEMBL database.\\\\n\\\\n### SMAD3\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n\\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 12606,\\n \\\"start_char_index\\\": 10810,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD3 has documented bioactivity evidence with 25 compounds showing IC50 values ranging from 38.00 nM to 9894.00 nM, with the most potent compounds being CHEMBL601757 (IC50=38.00 nM, pChEMBL=7.42) and CHEMBL1334062 (IC50=39.00 nM, pChEMBL=7.41)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\". \\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n\\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 12375,\\n \\\"start_char_index\\\": 10810,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Notable compounds include CHEMBL6246 (ELLAGIC ACID) with IC50=142.00 nM (pChEMBL=6.85)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Key Finding:** SMAD3 demonstrates significantly better druggability with validated small molecule inhibitors, while SMAD2 lacks such evidence.\\\\n\\\\n---\\\\n\\\\n## Structural Features Relevant to Druggability\\\\n\\\\n### Cysteine Residues (Potential Covalent Drug Targets)\\\\n\\\\n**SMAD2:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Has 14 detected cysteines, with 2 ligandable cysteines (Q15796_C74, Q15796_C81), 3 binding-site cysteines, and 2 near binding-site cysteines\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 9580,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Has only 5 detected cysteines, with 0 ligandable cysteines, though 3 are binding-site cysteines\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Implication:** SMAD2's ligandable cysteines (C74 and C81) represent potential sites for covalent inhibitor development, offering a druggability advantage over SMAD3 for this approach.\\\\n\\\\n### Protein Disorder and Binding Regions\\\\n\\\\n**SMAD2:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Shows 22.7% disordered regions with 3 disordered regions (longest=68 residues) and 14.1% high MoRF propensity (longest segment=66 residues)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 9580,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Shows 22.6% disordered regions with 4 disordered regions (longest=67 residues) and 13.9% high MoRF propensity (longest segment=59 residues)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Implication:** Both proteins have similar disorder profiles, suggesting comparable challenges for traditional small molecule binding but potential opportunities for targeting protein-protein interactions through MoRF regions.\\\\n\\\\n### Druggable Pockets\\\\n\\\\n**SMAD2:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"FPocket scores range from 0.0 to 0.713 (avg=0.037)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", with the maximum suggesting at least one potentially druggable pocket.\\\\n\\\\n**SMAD3:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 9580,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"FPocket scores range from 0.0 to 0.136 (avg=0.010)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", indicating lower overall pocket druggability.\\\\n\\\\n---\\\\n\\\\n## Targeting Strategies\\\\n\\\\n### 1. Direct Small Molecule Inhibition\\\\n\\\\n**Current Status:**\\\\n- **SMAD3:** Validated approach with nanomolar inhibitors available\\\\n- **SMAD2:** No validated small molecules reported\\\\n\\\\n**Challenges:**\\\\n- Both proteins function as transcription factors, traditionally considered \\\\\\\"undruggable\\\\\\\"\\\\n- High structural similarity between SMAD2 and SMAD3 may complicate selectivity\\\\n\\\\n### 2. Protein-Protein Interaction (PPI) Disruption\\\\n\\\\nBoth proteins form critical complexes:\\\\n\\\\n**SMAD2 interactions:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Forms heteromeric SMAD protein complexes and interacts with SMAD3, SMAD4, and numerous co-factors including CREBBP, EP300, SKI, SKIL\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3 interactions:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 9580,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Interacts with SMAD2, SMAD4, and similar co-factors, with documented co-crystal structures with SMAD3, SMAD4, and ZFYVE9\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Targeting opportunities:**\\\\n- SMAD2/3-SMAD4 heterotrimer formation\\\\n- Interactions with transcriptional co-activators (CREBBP, EP300)\\\\n- Interactions with inhibitory proteins (SKI, SKIL)\\\\n\\\\n### 3. Covalent Inhibitor Development\\\\n\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD2's two ligandable cysteines (C74, C81) near binding sites\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\" represent attractive targets for covalent inhibitors, potentially offering:\\\\n- Improved selectivity over SMAD3\\\\n- Enhanced potency through irreversible binding\\\\n- Longer duration of action\\\\n\\\\n### 4. Targeting Post-Translational Modifications\\\\n\\\\nBoth proteins undergo extensive regulation:\\\\n\\\\n**SMAD2:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Participates in pathways including \\\\\\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\\\\\" and \\\\\\\"Post-translational protein modification\\\\\\\"\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 9580,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Shows biochemical activity with multiple kinases (CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1) and deubiquitinases (OTUB1, USP15, USP7)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Targeting strategies:**\\\\n- Inhibit activating kinases (TGFBR1)\\\\n- Inhibit CDKs that phosphorylate linker regions\\\\n- Target E3 ubiquitin ligases (SMURF1, SMURF2, WWP2)\\\\n- Inhibit deubiquitinases to promote degradation\\\\n\\\\n### 5. Targeted Protein Degradation (PROTACs/Molecular Glues)\\\\n\\\\n**Advantages:**\\\\n- Circumvents need for traditional binding pockets\\\\n- Can achieve selectivity through E3 ligase recruitment\\\\n- Particularly attractive for SMAD2 given lack of direct inhibitors\\\\n\\\\n**Feasibility:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD2 interacts with multiple E3 ligases including SMURF2, WWP2, ITCH, NEDD4, NEDD4L\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", and \\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 9580,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD3 shows similar interactions with NEDD4, NEDD4L, SMURF1, SMURF2, WWP2\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", providing natural degradation pathways to exploit.\\\\n\\\\n---\\\\n\\\\n## Existing Therapeutic Approaches\\\\n\\\\n### Indirect Targeting via TGF-\\\\u03b2 Pathway\\\\n\\\\nBoth proteins are downstream of TGF-\\\\u03b2 receptor signaling:\\\\n\\\\n**SMAD2:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Participates in \\\\\\\"TGF-beta receptor signaling activates SMADs\\\\\\\" and \\\\\\\"Signaling by TGF-beta Receptor Complex\\\\\\\"\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 9580,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Similarly involved in TGF-\\\\u03b2 receptor signaling pathways\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Clinical relevance:**\\\\n- TGF-\\\\u03b2 receptor inhibitors (e.g., galunisertib) indirectly block SMAD2/3 activation\\\\n- This approach affects both proteins simultaneously, limiting selectivity\\\\n\\\\n---\\\\n\\\\n## Disease Context and Therapeutic Potential\\\\n\\\\n### SMAD2 Disease Associations\\\\n\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Ch\\\\u00e9diak-Higashi syndrome, \\\\u00c5land Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent M\\\\u00fcllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 39230,\\n \\\"start_char_index\\\": 19631,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD2 is associated with Loeys-Dietz syndrome 6, congenital heart defects, multiple types, 8, with or without heterotaxy, and numerous cancers including colorectal adenocarcinoma, glioblastoma, and breast cancer\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n### SMAD3 Disease Associations\\\\n\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 31176,\\n \\\"start_char_index\\\": 30923,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD3 is associated with Colorectal cancer and Loeys-Dietz syndrome 3\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", plus \\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Ch\\\\u00e9diak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, \\\\u00c5land Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 64988,\\n \\\"start_char_index\\\": 31176,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"extensive associations with cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Therapeutic implications:**\\\\n- **Cancer:** Both are tumor suppressors; inhibition may be contraindicated\\\\n- **Fibrosis:** SMAD3 inhibition shows promise (existing compounds available)\\\\n- **Cardiovascular disease:** Context-dependent; may require selective modulation\\\\n\\\\n---\\\\n\\\\n## Genetic Constraint and Safety Considerations\\\\n\\\\n### Loss-of-Function Tolerance\\\\n\\\\n**SMAD2:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0 *HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 43588,\\n \\\"start_char_index\\\": 42754,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Genetic constraint score for lof variants: 1.0 (mapped to LOEUF rank, lower = less tolerant)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555 *GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 69820,\\n \\\"start_char_index\\\": 68478,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Genetic constraint score for lof variants: 0.9999799728393555\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Interpretation:** Both proteins show high constraint scores (~1.0), indicating that loss-of-function variants are relatively well-tolerated in the population, suggesting potential safety for therapeutic inhibition.\\\\n\\\\n### Essentiality\\\\n\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 42754,\\n \\\"start_char_index\\\": 42599,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD2 is not a core essential gene\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", and \\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 68478,\\n \\\"start_char_index\\\": 68323,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD3 is not a core essential gene\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", indicating that complete inhibition may be tolerated, though context-dependent effects are likely.\\\\n\\\\n---\\\\n\\\\n## Tissue-Specific Expression Considerations\\\\n\\\\n### SMAD2\\\\n\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 42599,\\n \\\"start_char_index\\\": 39230,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Shows high tissue-specific expression (z-score \\\\u22652) in: segmented neutrophil of bone marrow (z=4), CD34-negative megakaryocyte cell (z=4), CD8-positive alpha-beta T cell (z=3), CD4-positive alpha-beta T cell (z=3), common lymphoid progenitor (z=3), conventional dendritic cell (z=4), CD4-positive alpha-beta thymocyte (z=5), CD8-positive alpha-beta thymocyte (z=4)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n### SMAD3\\\\n\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 68323,\\n \\\"start_char_index\\\": 64988,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Shows high tissue-specific expression in: CD14-positive, CD16-negative classical monocyte (z=3)\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", with generally lower tissue specificity than SMAD2.\\\\n\\\\n**Implication:** SMAD2's higher expression in immune cells may complicate systemic inhibition due to immunological effects, while SMAD3's broader expression pattern may present different toxicity concerns.\\\\n\\\\n---\\\\n\\\\n## Challenges and Considerations\\\\n\\\\n### 1. Selectivity Between SMAD2 and SMAD3\\\\n\\\\n- High structural similarity (both R-SMADs)\\\\n- Overlapping functions in TGF-\\\\u03b2 signaling\\\\n- \\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Both form SMAD2/SMAD3:SMAD4 heterotrimers\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\"\\\\n- Selective inhibition may require exploiting unique interaction surfaces or post-translational modification sites\\\\n\\\\n### 2. Context-Dependent Functions\\\\n\\\\n**Tumor suppressor vs. oncogenic roles:**\\\\n- In early cancer stages: tumor suppressive (inhibition contraindicated)\\\\n- In advanced cancer/metastasis: pro-metastatic (inhibition beneficial)\\\\n- Requires careful patient stratification\\\\n\\\\n### 3. Compensatory Mechanisms\\\\n\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 7603,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD2 shows phenotypic enhancement with SMAD3\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", and \\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 9580,\\n \\\"start_char_index\\\": 0,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"SMAD3 shows phenotypic enhancement with SMAD2\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\", suggesting functional redundancy that may limit single-target efficacy.\\\\n\\\\n### 4. Nuclear-Cytoplasmic Shuttling\\\\n\\\\n**SMAD2:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . \\\",\\n \\\"document_index\\\": 0,\\n \\\"document_title\\\": \\\"GENE: SMAD2\\\",\\n \\\"end_char_index\\\": 19228,\\n \\\"start_char_index\\\": 18833,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Cytoplasmic and nuclear in the absence of TGF-beta; migrates to nucleus when complexed with SMAD4 or IPO7 upon TGF-beta stimulation; released from complex and exported by RANBP1 upon dephosphorylation by PPM1A\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\\n\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": [\\n {\\n \\\"cited_text\\\": \\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . \\\",\\n \\\"document_index\\\": 1,\\n \\\"document_title\\\": \\\"GENE: SMAD3\\\",\\n \\\"end_char_index\\\": 30724,\\n \\\"start_char_index\\\": 30340,\\n \\\"type\\\": \\\"char_location\\\"\\n }\\n ],\\n \\\"text\\\": \\\"Shows similar cytoplasmic-nuclear shuttling; migrates to nucleus when complexed with SMAD4; released and exported by RANBP1 through PPM1A action\\\",\\n \\\"type\\\": \\\"text\\\"\\n },\\n {\\n \\\"citations\\\": null,\\n \\\"text\\\": \\\".\\\\n\\\\n**Implication:** Targeting nuclear import/export machinery or phosphatases (PPM1A) could modulate both proteins' activity.\\\\n\\\\n---\\\\n\\\\n## Summary and Recommendations\\\\n\\\\n### Druggability Ranking: SMAD3 > SMAD2\\\\n\\\\n**SMAD3 advantages:**\\\\n1. Validated small molecule inhibitors with nanomolar potency\\\\n2. Established screening assays and chemical starting points\\\\n3. Better characterized in fibrosis (clearer therapeutic indication)\\\\n\\\\n**SMAD2 advantages:**\\\\n1. Ligandable cysteines for covalent inhibitor development\\\\n2. Higher FPocket scores suggesting better pocket druggability\\\\n3. More tissue-restricted expression may reduce off-target effects\\\\n\\\\n### Recommended Targeting Approaches (Priority Order)\\\\n\\\\n1. **SMAD3 direct inhibition** (fibrosis, specific cancers)\\\\n - Build on existing nanomolar inhibitors\\\\n - Optimize for selectivity and pharmacokinetics\\\\n\\\\n2. **SMAD2 covalent inhibition** (cardiovascular, specific cancers)\\\\n - Target ligandable C74 or C81\\\\n - Develop selective covalent warheads\\\\n\\\\n3. **Dual SMAD2/3 PROTACs** (advanced cancers, severe fibrosis)\\\\n - Leverage endogenous E3 ligases (SMURF2, WWP2)\\\\n - Achieve complete pathway blockade\\\\n\\\\n4. **PPI disruption** (SMAD2/3-SMAD4 or co-factor interactions)\\\\n - Target heterotrimer formation\\\\n - Disrupt interactions with CREBBP/EP300\\\\n\\\\n5. **Upstream targeting** (TGF-\\\\u03b2 receptors, activating kinases)\\\\n - Indirect but clinically validated approach\\\\n - Affects both SMAD2 and SMAD3\\\\n\\\\n### Key Unresolved Issues\\\\n\\\\n1. **Selectivity:** Can SMAD2-selective or SMAD3-selective inhibitors be developed given structural similarity?\\\\n2. **Context-dependence:** How to stratify patients for tumor suppressor vs. pro-metastatic contexts?\\\\n3. **Redundancy:** Will single-target inhibition be sufficient or is dual targeting required?\\\\n4. **Biomarkers:** What pharmacodynamic markers can confirm target engagement in vivo?\\\\n5. **Resistance:** Will compensatory upregulation of parallel pathways limit efficacy?\\\\n\\\\n**Possible speculation:**\\\\n\\\\nGiven the existing SMAD3 inhibitors and SMAD2's ligandable cysteines, a rational drug development strategy might involve:\\\\n\\\\n1. **Near-term:** Optimize existing SMAD3 inhibitors for fibrosis indications where the therapeutic rationale is clearest\\\\n2. **Medium-term:** Develop SMAD2-selective covalent inhibitors targeting C74/C81 for cardiovascular indications (Loeys-Dietz syndrome)\\\\n3. **Long-term:** Create bifunctional degraders (PROTACs) for dual SMAD2/3 targeting in advanced cancers where complete pathway blockade is desired\\\\n\\\\nThe higher genetic constraint tolerance and non-essential status of both genes suggest that therapeutic inhibition may be feasible, though careful attention to tissue-specific and context-dependent effects will be critical for safety and efficacy.\\\",\\n \\\"type\\\": \\\"text\\\"\\n }\\n ],\\n \\\"model\\\": \\\"claude-sonnet-4-5-20250929\\\",\\n \\\"role\\\": \\\"assistant\\\",\\n \\\"stop_reason\\\": \\\"end_turn\\\",\\n \\\"stop_sequence\\\": null,\\n \\\"type\\\": \\\"message\\\",\\n \\\"usage\\\": {\\n \\\"cache_creation_input_tokens\\\": 0,\\n \\\"cache_read_input_tokens\\\": 0,\\n \\\"input_tokens\\\": 47531,\\n \\\"output_tokens\\\": 3916,\\n \\\"server_tool_use\\\": null,\\n \\\"service_tier\\\": \\\"standard\\\",\\n \\\"cache_creation\\\": {\\n \\\"ephemeral_5m_input_tokens\\\": 0,\\n \\\"ephemeral_1h_input_tokens\\\": 0\\n }\\n }\\n },\\n \\\"model_used\\\": \\\"claude-sonnet-4-5-20250929\\\"\\n },\\n \\\"verification\\\": {\\n \\\"verdict\\\": \\\"pass\\\",\\n \\\"statements\\\": [\\n {\\n \\\"text\\\": \\\"# Druggability Comparison: SMAD2 vs SMAD3\\\\n\\\\n## Direct Druggability Evidence\\\\n\\\\n### SMAD2\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header and does not make a factual claim requiring proof.\\\"\\n },\\n {\\n \\\"text\\\": \\\"No ChEMBL druggability data found for SMAD2\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof explicitly states 'No ChEMBL druggability data found' for SMAD2.\\\"\\n },\\n {\\n \\\"text\\\": \\\", indicating a lack of validated small molecule inhibitors or modulators in the ChEMBL database.\\\\n\\\\n### SMAD3\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a transitional statement connecting the lack of SMAD2 data to the discussion of SMAD3.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD3 has documented bioactivity evidence with 25 compounds showing IC50 values ranging from 38.00 nM to 9894.00 nM, with the most potent compounds being CHEMBL601757 (IC50=38.00 nM, pChEMBL=7.42) and CHEMBL1334062 (IC50=39.00 nM, pChEMBL=7.41)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes - Bioactivity values are normalized to nM and aggregated per compound. - Only positive numeric IC50 / Ki / EC50 values with molar units were considered. - Reported values are the lowest (strongest) potency observed per assay type. - pChEMBL is -log10(molar potency): higher values = stronger activity.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 10810,\\n 12606\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The IC50 range (38.00 nM to 9894.00 nM) and the two most potent compounds (CHEMBL601757 and CHEMBL1334062) are correctly cited. However, the statement says 'most potent compounds' and lists only two, while the proof shows 25 compounds. The statement is accurate but could be more precise about the number of compounds or the selection criteria for 'most potent.'\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a transitional punctuation mark.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Notable compounds include CHEMBL6246 (ELLAGIC ACID) with IC50=142.00 nM (pChEMBL=6.85)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes - Bioactivity values are normalized to nM and aggregated per compound.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 10810,\\n 12375\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof confirms CHEMBL6246 (ELLAGIC ACID) has IC50=142.00 nM and pChEMBL=6.85. However, the statement labels it as 'notable' without clear justification from the proof. It is the third most potent compound in the list, but the statement does not explain why it is singled out as 'notable' beyond being in the list.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Key Finding:** SMAD3 demonstrates significantly better druggability with validated small molecule inhibitors, while SMAD2 lacks such evidence.\\\\n\\\\n---\\\\n\\\\n## Structural Features Relevant to Druggability\\\\n\\\\n### Cysteine Residues (Potential Covalent Drug Targets)\\\\n\\\\n**SMAD2:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a transitional statement summarizing the key finding.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Has 14 detected cysteines, with 2 ligandable cysteines (Q15796_C74, Q15796_C81), 3 binding-site cysteines, and 2 near binding-site cysteines\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'detected=14, hyperreactive=0, ligandable=2' and lists 'Ligandable: Q15796_C74, Q15796_C81' and 'Near binding-site cysteines: Q15796_C70 C74, Q15796_C81 C74'. The claim about 2 ligandable cysteines, 3 binding-site cysteines, and 2 near binding-site cysteines is supported, though the proof format is complex.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Has only 5 detected cysteines, with 0 ligandable cysteines, though 3 are binding-site cysteines\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 0,\\n 9580\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0'. The claim about 5 detected cysteines, 0 ligandable cysteines, and 3 binding-site cysteines is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Implication:** SMAD2's ligandable cysteines (C74 and C81) represent potential sites for covalent inhibitor development, offering a druggability advantage over SMAD3 for this approach.\\\\n\\\\n### Protein Disorder and Binding Regions\\\\n\\\\n**SMAD2:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is an interpretive statement drawing a conclusion from the cysteine data. The implication is reasonable given the presence of ligandable cysteines in SMAD2 and their absence in SMAD3.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Shows 22.7% disordered regions with 3 disordered regions (longest=68 residues) and 14.1% high MoRF propensity (longest segment=66 residues)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'pct_disordered=22.698072805139187, num_regions=3, longest_region=68' and 'pct_high=14.132762312633833, longest_segment=66' for SMAD2. The percentages and region counts match the statement.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Shows 22.6% disordered regions with 4 disordered regions (longest=67 residues) and 13.9% high MoRF propensity (longest segment=59 residues)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 0,\\n 9580\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'pct_disordered=22.58823529411765, num_regions=4, longest_region=67' and 'pct_high=13.882352941176471, longest_segment=59' for SMAD3. The percentages and region counts match the statement.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Implication:** Both proteins have similar disorder profiles, suggesting comparable challenges for traditional small molecule binding but potential opportunities for targeting protein-protein interactions through MoRF regions.\\\\n\\\\n### Druggable Pockets\\\\n\\\\n**SMAD2:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is an interpretive statement drawing a conclusion from the disorder data. The implication is reasonable given the similar disorder profiles.\\\"\\n },\\n {\\n \\\"text\\\": \\\"FPocket scores range from 0.0 to 0.713 (avg=0.037)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'FPocket: min=0.0, max=0.713, avg=0.03704122055674514' for SMAD2. The range and average match the statement.\\\"\\n },\\n {\\n \\\"text\\\": \\\", with the maximum suggesting at least one potentially druggable pocket.\\\\n\\\\n**SMAD3:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is an interpretive statement suggesting that the maximum FPocket score indicates at least one potentially druggable pocket, which is a reasonable inference.\\\"\\n },\\n {\\n \\\"text\\\": \\\"FPocket scores range from 0.0 to 0.136 (avg=0.010)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 0,\\n 9580\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'FPocket: min=0.0, max=0.136, avg=0.009874901960784294' for SMAD3. The range and average match the statement.\\\"\\n },\\n {\\n \\\"text\\\": \\\", indicating lower overall pocket druggability.\\\\n\\\\n---\\\\n\\\\n## Targeting Strategies\\\\n\\\\n### 1. Direct Small Molecule Inhibition\\\\n\\\\n**Current Status:**\\\\n- **SMAD3:** Validated approach with nanomolar inhibitors available\\\\n- **SMAD2:** No validated small molecules reported\\\\n\\\\n**Challenges:**\\\\n- Both proteins function as transcription factors, traditionally considered \\\\\\\"undruggable\\\\\\\"\\\\n- High structural similarity between SMAD2 and SMAD3 may complicate selectivity\\\\n\\\\n### 2. Protein-Protein Interaction (PPI) Disruption\\\\n\\\\nBoth proteins form critical complexes:\\\\n\\\\n**SMAD2 interactions:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header and summary statement. The interpretation that SMAD3 has 'lower overall pocket druggability' is supported by the lower FPocket scores compared to SMAD2.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Forms heteromeric SMAD protein complexes and interacts with SMAD3, SMAD4, and numerous co-factors including CREBBP, EP300, SKI, SKIL\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists extensive interactions for SMAD2, including SMAD3, SMAD4, CREBBP, SKI, and SKIL. However, the proof is a very long list and does not explicitly highlight these as 'numerous co-factors.' The statement is generally correct but could be more precise about the number or significance of the co-factors.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3 interactions:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Interacts with SMAD2, SMAD4, and similar co-factors, with documented co-crystal structures with SMAD3, SMAD4, and ZFYVE9\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 0,\\n 9580\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists interactions for SMAD3, including SMAD2, SMAD4, and mentions 'Co-crystal Structure: SMAD3, SMAD4, ZFYVE9'. The statement is correct but the proof does not emphasize the co-crystal structures as prominently as the statement suggests. The claim about 'documented co-crystal structures' is supported but could be clearer.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Targeting opportunities:**\\\\n- SMAD2/3-SMAD4 heterotrimer formation\\\\n- Interactions with transcriptional co-activators (CREBBP, EP300)\\\\n- Interactions with inhibitory proteins (SKI, SKIL)\\\\n\\\\n### 3. Covalent Inhibitor Development\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header and summary statement. The targeting opportunities listed are reasonable inferences from the interaction data.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD2's two ligandable cysteines (C74, C81) near binding sites\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'Ligandable: Q15796_C74, Q15796_C81' and 'Near binding-site cysteines: Q15796_C70 C74, Q15796_C81 C74'. The claim about two ligandable cysteines near binding sites is supported, though the proof format is complex.\\\"\\n },\\n {\\n \\\"text\\\": \\\"represent attractive targets for covalent inhibitors, potentially offering:\\\\n- Improved selectivity over SMAD3\\\\n- Enhanced potency through irreversible binding\\\\n- Longer duration of action\\\\n\\\\n### 4. Targeting Post-Translational Modifications\\\\n\\\\nBoth proteins undergo extensive regulation:\\\\n\\\\n**SMAD2:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is an interpretive statement drawing conclusions from the cysteine data. The implications are reasonable given the presence of ligandable cysteines.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Participates in pathways including \\\\\\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\\\\\" and \\\\\\\"Post-translational protein modification\\\\\\\"\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists 'SMAD2/3 Phosphorylation Motif Mutants in Cancer' and 'Post-translational protein modification' in the pathways for SMAD2. The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Shows biochemical activity with multiple kinases (CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1) and deubiquitinases (OTUB1, USP15, USP7)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 0,\\n 9580\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists 'Biochemical Activity: CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2' for SMAD3. The statement correctly identifies the kinases and deubiquitinases.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Targeting strategies:**\\\\n- Inhibit activating kinases (TGFBR1)\\\\n- Inhibit CDKs that phosphorylate linker regions\\\\n- Target E3 ubiquitin ligases (SMURF1, SMURF2, WWP2)\\\\n- Inhibit deubiquitinases to promote degradation\\\\n\\\\n### 5. Targeted Protein Degradation (PROTACs/Molecular Glues)\\\\n\\\\n**Advantages:**\\\\n- Circumvents need for traditional binding pockets\\\\n- Can achieve selectivity through E3 ligase recruitment\\\\n- Particularly attractive for SMAD2 given lack of direct inhibitors\\\\n\\\\n**Feasibility:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header and summary statement. The targeting strategies listed are reasonable inferences from the biochemical activity data.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD2 interacts with multiple E3 ligases including SMURF2, WWP2, ITCH, NEDD4, NEDD4L\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists extensive interactions for SMAD2, including 'Affinity Capture-Luminescence: SMAD3, SMAD4, SMURF2' and 'Affinity Capture-Western: ... ITCH, ... NEDD4, NEDD4L, ... WWP2, ...'. The statement is correct but the proof is a very long list and the specific E3 ligases are present but not highlighted. The claim about 'multiple E3 ligases' is supported but could be more precise.\\\"\\n },\\n {\\n \\\"text\\\": \\\", and\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a transitional word.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD3 shows similar interactions with NEDD4, NEDD4L, SMURF1, SMURF2, WWP2\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 0,\\n 9580\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists extensive interactions for SMAD3, including 'Affinity Capture-Luminescence: ... SMURF1, SMURF2, ...' and 'Affinity Capture-Western: ... NEDD4, NEDD4L, ... SMURF1, SMURF2, ... WWP2, ...'. The statement is correct but the proof is a very long list and the specific E3 ligases are present but not highlighted. The claim about 'similar interactions' is supported but could be more precise.\\\"\\n },\\n {\\n \\\"text\\\": \\\", providing natural degradation pathways to exploit.\\\\n\\\\n---\\\\n\\\\n## Existing Therapeutic Approaches\\\\n\\\\n### Indirect Targeting via TGF-\\\\u03b2 Pathway\\\\n\\\\nBoth proteins are downstream of TGF-\\\\u03b2 receptor signaling:\\\\n\\\\n**SMAD2:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header and summary statement. The conclusion about 'natural degradation pathways to exploit' is a reasonable inference from the E3 ligase interaction data.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Participates in \\\\\\\"TGF-beta receptor signaling activates SMADs\\\\\\\" and \\\\\\\"Signaling by TGF-beta Receptor Complex\\\\\\\"\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists 'TGF-beta receptor signaling activates SMADs' and 'Signaling by TGF-beta Receptor Complex' in the pathways for SMAD2. The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Similarly involved in TGF-\\\\u03b2 receptor signaling pathways\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 0,\\n 9580\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists 'TGF-beta receptor signaling activates SMADs' and 'Signaling by TGF-beta Receptor Complex' in the pathways for SMAD3. The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Clinical relevance:**\\\\n- TGF-\\\\u03b2 receptor inhibitors (e.g., galunisertib) indirectly block SMAD2/3 activation\\\\n- This approach affects both proteins simultaneously, limiting selectivity\\\\n\\\\n---\\\\n\\\\n## Disease Context and Therapeutic Potential\\\\n\\\\n### SMAD2 Disease Associations\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header and summary statement. The clinical relevance of TGF-\\\\u03b2 receptor inhibitors is a reasonable inference from the pathway data, though the specific example of galunisertib is not directly supported by the proofs.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD2 is associated with Loeys-Dietz syndrome 6, congenital heart defects, multiple types, 8, with or without heterotaxy, and numerous cancers including colorectal adenocarcinoma, glioblastoma, and breast cancer\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Ch\\\\u00e9diak-Higashi syndrome, \\\\u00c5land Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent M\\\\u00fcllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19\\\\u2013associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 19631,\\n 39230\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists extensive disease associations for SMAD2, including 'Loeys-Dietz syndrome 6', 'congenital heart defects, multiple types, 8, with or without heterotaxy', 'colorectal adenocarcinoma', 'glioblastoma', and 'breast cancer'. However, the proof is a very long list and the specific diseases mentioned are present but not emphasized. The statement is correct but could be more precise about the number or significance of the associations.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n### SMAD3 Disease Associations\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD3 is associated with Colorectal cancer and Loeys-Dietz syndrome 3\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 30923,\\n 31176\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3' for SMAD3. The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\", plus\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a transitional word.\\\"\\n },\\n {\\n \\\"text\\\": \\\"extensive associations with cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infa\\\\u2026\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 31176,\\n 64988\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists extensive disease associations for SMAD3, including cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers. However, the proof is a very long list and the statement's claim about 'extensive associations' is supported but could be more specific about the number or significance of the associations.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Therapeutic implications:**\\\\n- **Cancer:** Both are tumor suppressors; inhibition may be contraindicated\\\\n- **Fibrosis:** SMAD3 inhibition shows promise (existing compounds available)\\\\n- **Cardiovascular disease:** Context-dependent; may require selective modulation\\\\n\\\\n---\\\\n\\\\n## Genetic Constraint and Safety Considerations\\\\n\\\\n### Loss-of-Function Tolerance\\\\n\\\\n**SMAD2:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header and summary statement. The therapeutic implications are reasonable inferences from the disease association data.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Genetic constraint score for lof variants: 1.0 (mapped to LOEUF rank, lower = less tolerant)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0 *HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 42754,\\n 43588\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'Genetic constraint score for lof variants ... in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0'. The score is correct, but the interpretation '(lower = less tolerant)' is added by the statement and not explicitly in the proof. The statement is correct but could clarify that the interpretation is based on the LOEUF rank mapping.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Genetic constraint score for lof variants: 0.9999799728393555\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555 *GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 68478,\\n 69820\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'Genetic constraint score for lof variants ... in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555'. The score is correct, but the interpretation is added by the statement and not explicitly in the proof. The statement is correct but could clarify that the interpretation is based on the LOEUF rank mapping.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Interpretation:** Both proteins show high constraint scores (~1.0), indicating that loss-of-function variants are relatively well-tolerated in the population, suggesting potential safety for therapeutic inhibition.\\\\n\\\\n### Essentiality\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is an interpretive statement drawing conclusions from the genetic constraint data. The interpretation that high constraint scores (~1.0) indicate that loss-of-function variants are relatively well-tolerated is reasonable, though the proof does not explicitly state this interpretation.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD2 is not a core essential gene\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 42599,\\n 42754\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).' The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\", and\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a transitional word.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD3 is not a core essential gene\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 68323,\\n 68478\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).' The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\", indicating that complete inhibition may be tolerated, though context-dependent effects are likely.\\\\n\\\\n---\\\\n\\\\n## Tissue-Specific Expression Considerations\\\\n\\\\n### SMAD2\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is an interpretive statement drawing conclusions from the essentiality data. The interpretation is reasonable given the non-essential status of both genes.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Shows high tissue-specific expression (z-score \\\\u22652) in: segmented neutrophil of bone marrow (z=4), CD34-negative megakaryocyte cell (z=4), CD8-positive alpha-beta T cell (z=3), CD4-positive alpha-beta T cell (z=3), common lymphoid progenitor (z=3), conventional dendritic cell (z=4), CD4-positive alpha-beta thymocyte (z=5), CD8-positive alpha-beta thymocyte (z=4)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 39230,\\n 42599\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof provides a dictionary of tissue-specific expression z-scores for SMAD2. The statement lists specific tissues with z-scores \\\\u22652, which are present in the proof (e.g., 'segmented neutrophil of bone marrow': 4, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, etc.). However, the proof is a large dictionary and the specific tissues mentioned are present but not highlighted. The statement is correct but could be more precise about the selection criteria or the number of tissues.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n### SMAD3\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Shows high tissue-specific expression in: CD14-positive, CD16-negative classical monocyte (z=3)\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 64988,\\n 68323\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"partial\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof provides a dictionary of tissue-specific expression z-scores for SMAD3. The statement lists 'CD14-positive, CD16-negative classical monocyte (z=3)', which is present in the proof. However, the proof is a large dictionary and only one tissue is mentioned in the statement, while the proof shows multiple tissues with varying z-scores. The statement is correct but could be more comprehensive.\\\"\\n },\\n {\\n \\\"text\\\": \\\", with generally lower tissue specificity than SMAD2.\\\\n\\\\n**Implication:** SMAD2's higher expression in immune cells may complicate systemic inhibition due to immunological effects, while SMAD3's broader expression pattern may present different toxicity concerns.\\\\n\\\\n---\\\\n\\\\n## Challenges and Considerations\\\\n\\\\n### 1. Selectivity Between SMAD2 and SMAD3\\\\n\\\\n- High structural similarity (both R-SMADs)\\\\n- Overlapping functions in TGF-\\\\u03b2 signaling\\\\n-\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is an interpretive statement drawing conclusions from the tissue-specific expression data. The interpretation that SMAD3 has 'generally lower tissue specificity than SMAD2' is reasonable given the data.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Both form SMAD2/SMAD3:SMAD4 heterotrimers\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists 'Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer' and 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription' in the pathways for SMAD2. The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\"- Selective inhibition may require exploiting unique interaction surfaces or post-translational modification sites\\\\n\\\\n### 2. Context-Dependent Functions\\\\n\\\\n**Tumor suppressor vs. oncogenic roles:**\\\\n- In early cancer stages: tumor suppressive (inhibition contraindicated)\\\\n- In advanced cancer/metastasis: pro-metastatic (inhibition beneficial)\\\\n- Requires careful patient stratification\\\\n\\\\n### 3. Compensatory Mechanisms\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a summary statement listing challenges. The challenges are reasonable inferences from the data, though some are not directly supported by the proofs (e.g., the need for 'exploiting unique interaction surfaces').\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD2 shows phenotypic enhancement with SMAD3\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 0,\\n 7603\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists 'Phenotypic Enhancement: SMAD3, SNW1' for SMAD2. The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\", and\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a transitional word.\\\"\\n },\\n {\\n \\\"text\\\": \\\"SMAD3 shows phenotypic enhancement with SMAD2\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 0,\\n 9580\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof lists 'Phenotypic Enhancement: HIF1A, SMAD2, SNW1' for SMAD3. The statement is correct.\\\"\\n },\\n {\\n \\\"text\\\": \\\", suggesting functional redundancy that may limit single-target efficacy.\\\\n\\\\n### 4. Nuclear-Cytoplasmic Shuttling\\\\n\\\\n**SMAD2:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is an interpretive statement drawing conclusions from the phenotypic enhancement data. The interpretation about 'functional redundancy' is reasonable given the mutual enhancement.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Cytoplasmic and nuclear in the absence of TGF-beta; migrates to nucleus when complexed with SMAD4 or IPO7 upon TGF-beta stimulation; released from complex and exported by RANBP1 upon dephosphorylation by PPM1A\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 .\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 0,\\n \\\"char_range\\\": [\\n 18833,\\n 19228\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.' The statement is correct, though the proof is dense.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**SMAD3:**\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a section header.\\\"\\n },\\n {\\n \\\"text\\\": \\\"Shows similar cytoplasmic-nuclear shuttling; migrates to nucleus when complexed with SMAD4; released and exported by RANBP1 through PPM1A action\\\",\\n \\\"proofs\\\": [\\n {\\n \\\"cited_text\\\": \\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus \\\\u2014 Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 .\\\",\\n \\\"title\\\": null,\\n \\\"document_index\\\": 1,\\n \\\"char_range\\\": [\\n 30340,\\n 30724\\n ]\\n }\\n ],\\n \\\"verdict\\\": \\\"supported\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"The proof states 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.' The statement is correct, though the proof is dense.\\\"\\n },\\n {\\n \\\"text\\\": \\\".\\\\n\\\\n**Implication:** Targeting nuclear import/export machinery or phosphatases (PPM1A) could modulate both proteins' activity.\\\\n\\\\n---\\\\n\\\\n## Summary and Recommendations\\\\n\\\\n### Druggability Ranking: SMAD3 > SMAD2\\\\n\\\\n**SMAD3 advantages:**\\\\n1. Validated small molecule inhibitors with nanomolar potency\\\\n2. Established screening assays and chemical starting points\\\\n3. Better characterized in fibrosis (clearer therapeutic indication)\\\\n\\\\n**SMAD2 advantages:**\\\\n1. Ligandable cysteines for covalent inhibitor development\\\\n2. Higher FPocket scores suggesting better pocket druggability\\\\n3. More tissue-restricted expression may reduce off-target effects\\\\n\\\\n### Recommended Targeting Approaches (Priority Order)\\\\n\\\\n1. **SMAD3 direct inhibition** (fibrosis, specific cancers)\\\\n - Build on existing nanomolar inhibitors\\\\n - Optimize for selectivity and pharmacokinetics\\\\n\\\\n2. **SMAD2 covalent inhibition** (cardiovascular, specific cancers)\\\\n - Target ligandable C74 or C81\\\\n - Develop selective covalent warheads\\\\n\\\\n3. **Dual SMAD2/3 PROTACs** (advanced cancers, severe fibrosis)\\\\n - Leverage endogenous E3 ligases (SMURF2, WWP2)\\\\n - Achieve complete pathway blockade\\\\n\\\\n4. **PPI disruption** (SMAD2/3-SMAD4 or co-factor interactions)\\\\n - Target heterotrimer formation\\\\n - Disrupt interactions with CREBBP/EP300\\\\n\\\\n5. **Upstream targeting** (TGF-\\\\u03b2 receptors, activating kinases)\\\\n - Indirect but clinically validated approach\\\\n - Affects both SMAD2 and SMAD3\\\\n\\\\n### Key Unresolved Issues\\\\n\\\\n1. **Selectivity:** Can SMAD2-selective or SMAD3-selective inhibitors be developed given structural similarity?\\\\n2. **Context-dependence:** How to stratify patients for tumor suppressor vs. pro-metastatic contexts?\\\\n3. **Redundancy:** Will single-target inhibition be sufficient or is dual targeting required?\\\\n4. **Biomarkers:** What pharmacodynamic markers can confirm target engagement in vivo?\\\\n5. **Resistance:** Will compensatory upregulation of parallel pathways limit efficacy?\\\\n\\\\n**Possible speculation:**\\\\n\\\\nGiven the existing SMAD3 inhibitors and SMAD2's ligandable cysteines, a rational drug development strategy might involve:\\\\n\\\\n1. **Near-term:** Optimize existing SMAD3 inhibitors for fibrosis indications where the therapeutic rationale is clearest\\\\n2. **Medium-term:** Develop SMAD2-selective covalent inhibitors targeting C74/C81 for cardiovascular indications (Loeys-Dietz syndrome)\\\\n3. **Long-term:** Create bifunctional degraders (PROTACs) for dual SMAD2/3 targeting in advanced cancers where complete pathway blockade is desired\\\\n\\\\nThe higher genetic constraint tolerance and non-essential status of both genes suggest that therapeutic inhibition may be feasible, though careful attention to tissue-specific and context-dependent effects will be critical for safety and efficacy.\\\",\\n \\\"proofs\\\": [],\\n \\\"verdict\\\": \\\"speculation-ok\\\",\\n \\\"reasons\\\": [],\\n \\\"is_speculation\\\": false,\\n \\\"llm_feedback\\\": \\\"This is a speculative section, appropriately labeled with 'Possible speculation:' at the end. The recommendations are generally grounded in the cited evidence (e.g., existing SMAD3 inhibitors, SMAD2's ligandable cysteines, genetic constraint tolerance). However, some recommendations (e.g., specific drug development timelines, PROTAC strategies) extend beyond what the proofs explicitly support. The speculation is cautious and clearly marked, so it is acceptable, but users should verify these recommendations independently.\\\"\\n }\\n ],\\n \\\"summary\\\": {\\n \\\"supported\\\": 52,\\n \\\"partial\\\": 12,\\n \\\"unsupported\\\": 0\\n },\\n \\\"evidence\\\": {\\n \\\"overall\\\": {\\n \\\"support_quality\\\": \\\"medium\\\",\\n \\\"summary\\\": \\\"The answer provides a comprehensive comparison of SMAD2 and SMAD3 druggability, drawing on structural features, bioactivity data, protein interactions, and disease associations. Most core factual claims are supported by the provided proofs. However, several statements are labeled 'partial' or 'unsupported' due to minor exaggerations, missing details, or claims that extend slightly beyond what the proofs explicitly state. The speculative section at the end is appropriately labeled and generally grounded in the evidence, though some recommendations lack direct proof support.\\\",\\n \\\"concerns\\\": [\\n \\\"Statement 3: The IC50 range endpoint (9894.00 nM) is correct, but the claim about 'most potent compounds' lists only two examples when the proof shows 25 compounds; the statement could be more precise.\\\",\\n \\\"Statement 5: The claim about 'notable compounds' singles out ellagic acid without clear justification for why it is 'notable' beyond being in the list.\\\",\\n \\\"Statement 7: The claim about 'near binding-site cysteines' is supported, but the proof snippet is complex and the specific detail about C70 and C81 being 'near' C74 is present but could be clearer.\\\",\\n \\\"Statement 9: The claim about SMAD3 having '0 ligandable cysteines' is correct, but the statement could acknowledge that 3 binding-site cysteines are present.\\\",\\n \\\"Statement 19: The claim about SMAD2 interactions is generally supported, but the proof is a large list and the specific co-factors mentioned (CREBBP, EP300, SKI, SKIL) are present but not highlighted as 'numerous' in a quantified way.\\\",\\n \\\"Statement 21: The claim about SMAD3 interactions and 'documented co-crystal structures' is supported, but the proof does not emphasize the co-crystal structures as prominently as the statement suggests.\\\",\\n \\\"Statement 23: The claim about 'ligandable cysteines near binding sites' is supported, but the proof is dense and the specific proximity claim is implicit.\\\",\\n \\\"Statement 29: The claim about SMAD2 interacting with 'multiple E3 ligases' is supported, but the proof is a large interaction list and the specific ligases are present but not highlighted.\\\",\\n \\\"Statement 31: Similar to statement 29, the claim about SMAD3 interactions is supported but the proof is a large list.\\\",\\n \\\"Statement 37: The disease associations for SMAD2 are supported, but the proof is a very long list and the specific diseases mentioned are present but not emphasized.\\\",\\n \\\"Statement 39: The disease associations for SMAD3 are supported, but the proof is brief and does not list all the diseases mentioned in statement 41.\\\",\\n \\\"Statement 41: The claim about 'extensive associations' is supported by the proof, but the proof is a very long list and the statement could be more specific.\\\",\\n \\\"Statement 43: The genetic constraint score is correct, but the interpretation '(lower = less tolerant)' is added by the statement and not explicitly in the proof.\\\",\\n \\\"Statement 45: Similar to statement 43, the score is correct but the interpretation is added.\\\",\\n \\\"Statement 51: The tissue-specific expression claim is supported, but the proof is a large dictionary and the specific tissues mentioned are present but not highlighted.\\\",\\n \\\"Statement 53: The tissue-specific expression claim is supported, but the proof is a large dictionary and only one tissue is mentioned.\\\",\\n \\\"Statement 61: The claim about SMAD2 localization is supported, but the proof is dense and the specific details about PPM1A and RANBP1 are present but not emphasized.\\\",\\n \\\"Statement 63: Similar to statement 61, the claim is supported but the proof is dense.\\\",\\n \\\"The speculative section (statement 64) is appropriately labeled but some recommendations lack direct proof support and are based on synthesis of the evidence.\\\"\\n ],\\n \\\"suggestions\\\": [\\n \\\"For statements with large proof lists (e.g., interactions, disease associations), consider summarizing the proof or highlighting the specific entities mentioned in the statement.\\\",\\n \\\"For statements about 'notable' or 'most potent' compounds, provide clearer justification or quantification.\\\",\\n \\\"For statements about genetic constraint scores, clarify the interpretation of the scores in the proof or statement.\\\",\\n \\\"For speculative recommendations, ensure they are clearly grounded in the cited evidence and avoid overreach.\\\",\\n \\\"Consider breaking down complex statements into smaller, more verifiable claims.\\\"\\n ]\\n },\\n \\\"per_statement\\\": {\\n \\\"0\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header and does not make a factual claim requiring proof.\\\"\\n },\\n \\\"1\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof explicitly states 'No ChEMBL druggability data found' for SMAD2.\\\"\\n },\\n \\\"2\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a transitional statement connecting the lack of SMAD2 data to the discussion of SMAD3.\\\"\\n },\\n \\\"3\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The IC50 range (38.00 nM to 9894.00 nM) and the two most potent compounds (CHEMBL601757 and CHEMBL1334062) are correctly cited. However, the statement says 'most potent compounds' and lists only two, while the proof shows 25 compounds. The statement is accurate but could be more precise about the number of compounds or the selection criteria for 'most potent.'\\\"\\n },\\n \\\"4\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a transitional punctuation mark.\\\"\\n },\\n \\\"5\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof confirms CHEMBL6246 (ELLAGIC ACID) has IC50=142.00 nM and pChEMBL=6.85. However, the statement labels it as 'notable' without clear justification from the proof. It is the third most potent compound in the list, but the statement does not explain why it is singled out as 'notable' beyond being in the list.\\\"\\n },\\n \\\"6\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a transitional statement summarizing the key finding.\\\"\\n },\\n \\\"7\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'detected=14, hyperreactive=0, ligandable=2' and lists 'Ligandable: Q15796_C74, Q15796_C81' and 'Near binding-site cysteines: Q15796_C70 C74, Q15796_C81 C74'. The claim about 2 ligandable cysteines, 3 binding-site cysteines, and 2 near binding-site cysteines is supported, though the proof format is complex.\\\"\\n },\\n \\\"8\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"9\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0'. The claim about 5 detected cysteines, 0 ligandable cysteines, and 3 binding-site cysteines is correct.\\\"\\n },\\n \\\"10\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is an interpretive statement drawing a conclusion from the cysteine data. The implication is reasonable given the presence of ligandable cysteines in SMAD2 and their absence in SMAD3.\\\"\\n },\\n \\\"11\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'pct_disordered=22.698072805139187, num_regions=3, longest_region=68' and 'pct_high=14.132762312633833, longest_segment=66' for SMAD2. The percentages and region counts match the statement.\\\"\\n },\\n \\\"12\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"13\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'pct_disordered=22.58823529411765, num_regions=4, longest_region=67' and 'pct_high=13.882352941176471, longest_segment=59' for SMAD3. The percentages and region counts match the statement.\\\"\\n },\\n \\\"14\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is an interpretive statement drawing a conclusion from the disorder data. The implication is reasonable given the similar disorder profiles.\\\"\\n },\\n \\\"15\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'FPocket: min=0.0, max=0.713, avg=0.03704122055674514' for SMAD2. The range and average match the statement.\\\"\\n },\\n \\\"16\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is an interpretive statement suggesting that the maximum FPocket score indicates at least one potentially druggable pocket, which is a reasonable inference.\\\"\\n },\\n \\\"17\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'FPocket: min=0.0, max=0.136, avg=0.009874901960784294' for SMAD3. The range and average match the statement.\\\"\\n },\\n \\\"18\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header and summary statement. The interpretation that SMAD3 has 'lower overall pocket druggability' is supported by the lower FPocket scores compared to SMAD2.\\\"\\n },\\n \\\"19\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof lists extensive interactions for SMAD2, including SMAD3, SMAD4, CREBBP, SKI, and SKIL. However, the proof is a very long list and does not explicitly highlight these as 'numerous co-factors.' The statement is generally correct but could be more precise about the number or significance of the co-factors.\\\"\\n },\\n \\\"20\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"21\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof lists interactions for SMAD3, including SMAD2, SMAD4, and mentions 'Co-crystal Structure: SMAD3, SMAD4, ZFYVE9'. The statement is correct but the proof does not emphasize the co-crystal structures as prominently as the statement suggests. The claim about 'documented co-crystal structures' is supported but could be clearer.\\\"\\n },\\n \\\"22\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header and summary statement. The targeting opportunities listed are reasonable inferences from the interaction data.\\\"\\n },\\n \\\"23\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'Ligandable: Q15796_C74, Q15796_C81' and 'Near binding-site cysteines: Q15796_C70 C74, Q15796_C81 C74'. The claim about two ligandable cysteines near binding sites is supported, though the proof format is complex.\\\"\\n },\\n \\\"24\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is an interpretive statement drawing conclusions from the cysteine data. The implications are reasonable given the presence of ligandable cysteines.\\\"\\n },\\n \\\"25\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof lists 'SMAD2/3 Phosphorylation Motif Mutants in Cancer' and 'Post-translational protein modification' in the pathways for SMAD2. The statement is correct.\\\"\\n },\\n \\\"26\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"27\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof lists 'Biochemical Activity: CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2' for SMAD3. The statement correctly identifies the kinases and deubiquitinases.\\\"\\n },\\n \\\"28\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header and summary statement. The targeting strategies listed are reasonable inferences from the biochemical activity data.\\\"\\n },\\n \\\"29\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof lists extensive interactions for SMAD2, including 'Affinity Capture-Luminescence: SMAD3, SMAD4, SMURF2' and 'Affinity Capture-Western: ... ITCH, ... NEDD4, NEDD4L, ... WWP2, ...'. The statement is correct but the proof is a very long list and the specific E3 ligases are present but not highlighted. The claim about 'multiple E3 ligases' is supported but could be more precise.\\\"\\n },\\n \\\"30\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a transitional word.\\\"\\n },\\n \\\"31\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof lists extensive interactions for SMAD3, including 'Affinity Capture-Luminescence: ... SMURF1, SMURF2, ...' and 'Affinity Capture-Western: ... NEDD4, NEDD4L, ... SMURF1, SMURF2, ... WWP2, ...'. The statement is correct but the proof is a very long list and the specific E3 ligases are present but not highlighted. The claim about 'similar interactions' is supported but could be more precise.\\\"\\n },\\n \\\"32\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header and summary statement. The conclusion about 'natural degradation pathways to exploit' is a reasonable inference from the E3 ligase interaction data.\\\"\\n },\\n \\\"33\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof lists 'TGF-beta receptor signaling activates SMADs' and 'Signaling by TGF-beta Receptor Complex' in the pathways for SMAD2. The statement is correct.\\\"\\n },\\n \\\"34\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"35\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof lists 'TGF-beta receptor signaling activates SMADs' and 'Signaling by TGF-beta Receptor Complex' in the pathways for SMAD3. The statement is correct.\\\"\\n },\\n \\\"36\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header and summary statement. The clinical relevance of TGF-\\\\u03b2 receptor inhibitors is a reasonable inference from the pathway data, though the specific example of galunisertib is not directly supported by the proofs.\\\"\\n },\\n \\\"37\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof lists extensive disease associations for SMAD2, including 'Loeys-Dietz syndrome 6', 'congenital heart defects, multiple types, 8, with or without heterotaxy', 'colorectal adenocarcinoma', 'glioblastoma', and 'breast cancer'. However, the proof is a very long list and the specific diseases mentioned are present but not emphasized. The statement is correct but could be more precise about the number or significance of the associations.\\\"\\n },\\n \\\"38\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"39\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3' for SMAD3. The statement is correct.\\\"\\n },\\n \\\"40\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a transitional word.\\\"\\n },\\n \\\"41\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof lists extensive disease associations for SMAD3, including cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers. However, the proof is a very long list and the statement's claim about 'extensive associations' is supported but could be more specific about the number or significance of the associations.\\\"\\n },\\n \\\"42\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header and summary statement. The therapeutic implications are reasonable inferences from the disease association data.\\\"\\n },\\n \\\"43\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof states 'Genetic constraint score for lof variants ... in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0'. The score is correct, but the interpretation '(lower = less tolerant)' is added by the statement and not explicitly in the proof. The statement is correct but could clarify that the interpretation is based on the LOEUF rank mapping.\\\"\\n },\\n \\\"44\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"45\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof states 'Genetic constraint score for lof variants ... in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555'. The score is correct, but the interpretation is added by the statement and not explicitly in the proof. The statement is correct but could clarify that the interpretation is based on the LOEUF rank mapping.\\\"\\n },\\n \\\"46\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is an interpretive statement drawing conclusions from the genetic constraint data. The interpretation that high constraint scores (~1.0) indicate that loss-of-function variants are relatively well-tolerated is reasonable, though the proof does not explicitly state this interpretation.\\\"\\n },\\n \\\"47\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).' The statement is correct.\\\"\\n },\\n \\\"48\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a transitional word.\\\"\\n },\\n \\\"49\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).' The statement is correct.\\\"\\n },\\n \\\"50\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is an interpretive statement drawing conclusions from the essentiality data. The interpretation is reasonable given the non-essential status of both genes.\\\"\\n },\\n \\\"51\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof provides a dictionary of tissue-specific expression z-scores for SMAD2. The statement lists specific tissues with z-scores \\\\u22652, which are present in the proof (e.g., 'segmented neutrophil of bone marrow': 4, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, etc.). However, the proof is a large dictionary and the specific tissues mentioned are present but not highlighted. The statement is correct but could be more precise about the selection criteria or the number of tissues.\\\"\\n },\\n \\\"52\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"53\\\": {\\n \\\"label\\\": \\\"partial\\\",\\n \\\"feedback\\\": \\\"The proof provides a dictionary of tissue-specific expression z-scores for SMAD3. The statement lists 'CD14-positive, CD16-negative classical monocyte (z=3)', which is present in the proof. However, the proof is a large dictionary and only one tissue is mentioned in the statement, while the proof shows multiple tissues with varying z-scores. The statement is correct but could be more comprehensive.\\\"\\n },\\n \\\"54\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is an interpretive statement drawing conclusions from the tissue-specific expression data. The interpretation that SMAD3 has 'generally lower tissue specificity than SMAD2' is reasonable given the data.\\\"\\n },\\n \\\"55\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof lists 'Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer' and 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription' in the pathways for SMAD2. The statement is correct.\\\"\\n },\\n \\\"56\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a summary statement listing challenges. The challenges are reasonable inferences from the data, though some are not directly supported by the proofs (e.g., the need for 'exploiting unique interaction surfaces').\\\"\\n },\\n \\\"57\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof lists 'Phenotypic Enhancement: SMAD3, SNW1' for SMAD2. The statement is correct.\\\"\\n },\\n \\\"58\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a transitional word.\\\"\\n },\\n \\\"59\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof lists 'Phenotypic Enhancement: HIF1A, SMAD2, SNW1' for SMAD3. The statement is correct.\\\"\\n },\\n \\\"60\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is an interpretive statement drawing conclusions from the phenotypic enhancement data. The interpretation about 'functional redundancy' is reasonable given the mutual enhancement.\\\"\\n },\\n \\\"61\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.' The statement is correct, though the proof is dense.\\\"\\n },\\n \\\"62\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"This is a section header.\\\"\\n },\\n \\\"63\\\": {\\n \\\"label\\\": \\\"supported\\\",\\n \\\"feedback\\\": \\\"The proof states 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.' The statement is correct, though the proof is dense.\\\"\\n },\\n \\\"64\\\": {\\n \\\"label\\\": \\\"speculation-ok\\\",\\n \\\"feedback\\\": \\\"This is a speculative section, appropriately labeled with 'Possible speculation:' at the end. The recommendations are generally grounded in the cited evidence (e.g., existing SMAD3 inhibitors, SMAD2's ligandable cysteines, genetic constraint tolerance). However, some recommendations (e.g., specific drug development timelines, PROTAC strategies) extend beyond what the proofs explicitly support. The speculation is cautious and clearly marked, so it is acceptable, but users should verify these recommendations independently.\\\"\\n }\\n }\\n },\\n \\\"retry_feedback\\\": {\\n \\\"summary\\\": \\\"The answer provides a comprehensive comparison of SMAD2 and SMAD3 druggability, drawing on structural features, bioactivity data, protein interactions, and disease associations. Most core factual claims are supported by the provided proofs. However, several statements are labeled 'partial' or 'unsupported' due to minor exaggerations, missing details, or claims that extend slightly beyond what the proofs explicitly state. The speculative section at the end is appropriately labeled and generally grounded in the evidence, though some recommendations lack direct proof support.\\\",\\n \\\"concerns\\\": [\\n \\\"Statement 3: The IC50 range endpoint (9894.00 nM) is correct, but the claim about 'most potent compounds' lists only two examples when the proof shows 25 compounds; the statement could be more precise.\\\",\\n \\\"Statement 5: The claim about 'notable compounds' singles out ellagic acid without clear justification for why it is 'notable' beyond being in the list.\\\",\\n \\\"Statement 7: The claim about 'near binding-site cysteines' is supported, but the proof snippet is complex and the specific detail about C70 and C81 being 'near' C74 is present but could be clearer.\\\",\\n \\\"Statement 9: The claim about SMAD3 having '0 ligandable cysteines' is correct, but the statement could acknowledge that 3 binding-site cysteines are present.\\\",\\n \\\"Statement 19: The claim about SMAD2 interactions is generally supported, but the proof is a large list and the specific co-factors mentioned (CREBBP, EP300, SKI, SKIL) are present but not highlighted as 'numerous' in a quantified way.\\\",\\n \\\"Statement 21: The claim about SMAD3 interactions and 'documented co-crystal structures' is supported, but the proof does not emphasize the co-crystal structures as prominently as the statement suggests.\\\",\\n \\\"Statement 23: The claim about 'ligandable cysteines near binding sites' is supported, but the proof is dense and the specific proximity claim is implicit.\\\",\\n \\\"Statement 29: The claim about SMAD2 interacting with 'multiple E3 ligases' is supported, but the proof is a large interaction list and the specific ligases are present but not highlighted.\\\",\\n \\\"Statement 31: Similar to statement 29, the claim about SMAD3 interactions is supported but the proof is a large list.\\\",\\n \\\"Statement 37: The disease associations for SMAD2 are supported, but the proof is a very long list and the specific diseases mentioned are present but not emphasized.\\\",\\n \\\"Statement 39: The disease associations for SMAD3 are supported, but the proof is brief and does not list all the diseases mentioned in statement 41.\\\",\\n \\\"Statement 41: The claim about 'extensive associations' is supported by the proof, but the proof is a very long list and the statement could be more specific.\\\",\\n \\\"Statement 43: The genetic constraint score is correct, but the interpretation '(lower = less tolerant)' is added by the statement and not explicitly in the proof.\\\",\\n \\\"Statement 45: Similar to statement 43, the score is correct but the interpretation is added.\\\",\\n \\\"Statement 51: The tissue-specific expression claim is supported, but the proof is a large dictionary and the specific tissues mentioned are present but not highlighted.\\\",\\n \\\"Statement 53: The tissue-specific expression claim is supported, but the proof is a large dictionary and only one tissue is mentioned.\\\",\\n \\\"Statement 61: The claim about SMAD2 localization is supported, but the proof is dense and the specific details about PPM1A and RANBP1 are present but not emphasized.\\\",\\n \\\"Statement 63: Similar to statement 61, the claim is supported but the proof is dense.\\\",\\n \\\"The speculative section (statement 64) is appropriately labeled but some recommendations lack direct proof support and are based on synthesis of the evidence.\\\"\\n ],\\n \\\"suggestions\\\": [\\n \\\"For statements with large proof lists (e.g., interactions, disease associations), consider summarizing the proof or highlighting the specific entities mentioned in the statement.\\\",\\n \\\"For statements about 'notable' or 'most potent' compounds, provide clearer justification or quantification.\\\",\\n \\\"For statements about genetic constraint scores, clarify the interpretation of the scores in the proof or statement.\\\",\\n \\\"For speculative recommendations, ensure they are clearly grounded in the cited evidence and avoid overreach.\\\",\\n \\\"Consider breaking down complex statements into smaller, more verifiable claims.\\\"\\n ]\\n },\\n \\\"answer\\\": \\\"# Druggability Comparison: SMAD2 vs SMAD3\\\\n\\\\n## Direct Druggability Evidence\\\\n\\\\n### SMAD2\\\\nNo ChEMBL druggability data found for SMAD2, indicating a lack of validated small molecule inhibitors or modulators in the ChEMBL database.\\\\n\\\\n### SMAD3\\\\nSMAD3 has documented bioactivity evidence with 25 compounds showing IC50 values ranging from 38.00 nM to 9894.00 nM, with the most potent compounds being CHEMBL601757 (IC50=38.00 nM, pChEMBL=7.42) and CHEMBL1334062 (IC50=39.00 nM, pChEMBL=7.41). Notable compounds include CHEMBL6246 (ELLAGIC ACID) with IC50=142.00 nM (pChEMBL=6.85).\\\\n\\\\n**Key Finding:** SMAD3 demonstrates significantly better druggability with validated small molecule inhibitors, while SMAD2 lacks such evidence.\\\\n\\\\n---\\\\n\\\\n## Structural Features Relevant to Druggability\\\\n\\\\n### Cysteine Residues (Potential Covalent Drug Targets)\\\\n\\\\n**SMAD2:**\\\\nHas 14 detected cysteines, with 2 ligandable cysteines (Q15796_C74, Q15796_C81), 3 binding-site cysteines, and 2 near binding-site cysteines.\\\\n\\\\n**SMAD3:**\\\\nHas only 5 detected cysteines, with 0 ligandable cysteines, though 3 are binding-site cysteines.\\\\n\\\\n**Implication:** SMAD2's ligandable cysteines (C74 and C81) represent potential sites for covalent inhibitor development, offering a druggability advantage over SMAD3 for this approach.\\\\n\\\\n### Protein Disorder and Binding Regions\\\\n\\\\n**SMAD2:**\\\\nShows 22.7% disordered regions with 3 disordered regions (longest=68 residues) and 14.1% high MoRF propensity (longest segment=66 residues).\\\\n\\\\n**SMAD3:**\\\\nShows 22.6% disordered regions with 4 disordered regions (longest=67 residues) and 13.9% high MoRF propensity (longest segment=59 residues).\\\\n\\\\n**Implication:** Both proteins have similar disorder profiles, suggesting comparable challenges for traditional small molecule binding but potential opportunities for targeting protein-protein interactions through MoRF regions.\\\\n\\\\n### Druggable Pockets\\\\n\\\\n**SMAD2:**\\\\nFPocket scores range from 0.0 to 0.713 (avg=0.037), with the maximum suggesting at least one potentially druggable pocket.\\\\n\\\\n**SMAD3:**\\\\nFPocket scores range from 0.0 to 0.136 (avg=0.010), indicating lower overall pocket druggability.\\\\n\\\\n---\\\\n\\\\n## Targeting Strategies\\\\n\\\\n### 1. Direct Small Molecule Inhibition\\\\n\\\\n**Current Status:**\\\\n- **SMAD3:** Validated approach with nanomolar inhibitors available\\\\n- **SMAD2:** No validated small molecules reported\\\\n\\\\n**Challenges:**\\\\n- Both proteins function as transcription factors, traditionally considered \\\\\\\"undruggable\\\\\\\"\\\\n- High structural similarity between SMAD2 and SMAD3 may complicate selectivity\\\\n\\\\n### 2. Protein-Protein Interaction (PPI) Disruption\\\\n\\\\nBoth proteins form critical complexes:\\\\n\\\\n**SMAD2 interactions:**\\\\nForms heteromeric SMAD protein complexes and interacts with SMAD3, SMAD4, and numerous co-factors including CREBBP, EP300, SKI, SKIL.\\\\n\\\\n**SMAD3 interactions:**\\\\nInteracts with SMAD2, SMAD4, and similar co-factors, with documented co-crystal structures with SMAD3, SMAD4, and ZFYVE9.\\\\n\\\\n**Targeting opportunities:**\\\\n- SMAD2/3-SMAD4 heterotrimer formation\\\\n- Interactions with transcriptional co-activators (CREBBP, EP300)\\\\n- Interactions with inhibitory proteins (SKI, SKIL)\\\\n\\\\n### 3. Covalent Inhibitor Development\\\\n\\\\nSMAD2's two ligandable cysteines (C74, C81) near binding sites represent attractive targets for covalent inhibitors, potentially offering:\\\\n- Improved selectivity over SMAD3\\\\n- Enhanced potency through irreversible binding\\\\n- Longer duration of action\\\\n\\\\n### 4. Targeting Post-Translational Modifications\\\\n\\\\nBoth proteins undergo extensive regulation:\\\\n\\\\n**SMAD2:**\\\\nParticipates in pathways including \\\\\\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\\\\\" and \\\\\\\"Post-translational protein modification\\\\\\\".\\\\n\\\\n**SMAD3:**\\\\nShows biochemical activity with multiple kinases (CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1) and deubiquitinases (OTUB1, USP15, USP7).\\\\n\\\\n**Targeting strategies:**\\\\n- Inhibit activating kinases (TGFBR1)\\\\n- Inhibit CDKs that phosphorylate linker regions\\\\n- Target E3 ubiquitin ligases (SMURF1, SMURF2, WWP2)\\\\n- Inhibit deubiquitinases to promote degradation\\\\n\\\\n### 5. Targeted Protein Degradation (PROTACs/Molecular Glues)\\\\n\\\\n**Advantages:**\\\\n- Circumvents need for traditional binding pockets\\\\n- Can achieve selectivity through E3 ligase recruitment\\\\n- Particularly attractive for SMAD2 given lack of direct inhibitors\\\\n\\\\n**Feasibility:**\\\\nSMAD2 interacts with multiple E3 ligases including SMURF2, WWP2, ITCH, NEDD4, NEDD4L, and SMAD3 shows similar interactions with NEDD4, NEDD4L, SMURF1, SMURF2, WWP2, providing natural degradation pathways to exploit.\\\\n\\\\n---\\\\n\\\\n## Existing Therapeutic Approaches\\\\n\\\\n### Indirect Targeting via TGF-\\\\u03b2 Pathway\\\\n\\\\nBoth proteins are downstream of TGF-\\\\u03b2 receptor signaling:\\\\n\\\\n**SMAD2:**\\\\nParticipates in \\\\\\\"TGF-beta receptor signaling activates SMADs\\\\\\\" and \\\\\\\"Signaling by TGF-beta Receptor Complex\\\\\\\".\\\\n\\\\n**SMAD3:**\\\\nSimilarly involved in TGF-\\\\u03b2 receptor signaling pathways.\\\\n\\\\n**Clinical relevance:**\\\\n- TGF-\\\\u03b2 receptor inhibitors (e.g., galunisertib) indirectly block SMAD2/3 activation\\\\n- This approach affects both proteins simultaneously, limiting selectivity\\\\n\\\\n---\\\\n\\\\n## Disease Context and Therapeutic Potential\\\\n\\\\n### SMAD2 Disease Associations\\\\n\\\\nSMAD2 is associated with Loeys-Dietz syndrome 6, congenital heart defects, multiple types, 8, with or without heterotaxy, and numerous cancers including colorectal adenocarcinoma, glioblastoma, and breast cancer.\\\\n\\\\n### SMAD3 Disease Associations\\\\n\\\\nSMAD3 is associated with Colorectal cancer and Loeys-Dietz syndrome 3, plus extensive associations with cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers.\\\\n\\\\n**Therapeutic implications:**\\\\n- **Cancer:** Both are tumor suppressors; inhibition may be contraindicated\\\\n- **Fibrosis:** SMAD3 inhibition shows promise (existing compounds available)\\\\n- **Cardiovascular disease:** Context-dependent; may require selective modulation\\\\n\\\\n---\\\\n\\\\n## Genetic Constraint and Safety Considerations\\\\n\\\\n### Loss-of-Function Tolerance\\\\n\\\\n**SMAD2:**\\\\nGenetic constraint score for lof variants: 1.0 (mapped to LOEUF rank, lower = less tolerant).\\\\n\\\\n**SMAD3:**\\\\nGenetic constraint score for lof variants: 0.9999799728393555.\\\\n\\\\n**Interpretation:** Both proteins show high constraint scores (~1.0), indicating that loss-of-function variants are relatively well-tolerated in the population, suggesting potential safety for therapeutic inhibition.\\\\n\\\\n### Essentiality\\\\n\\\\nSMAD2 is not a core essential gene, and SMAD3 is not a core essential gene, indicating that complete inhibition may be tolerated, though context-dependent effects are likely.\\\\n\\\\n---\\\\n\\\\n## Tissue-Specific Expression Considerations\\\\n\\\\n### SMAD2\\\\n\\\\nShows high tissue-specific expression (z-score \\\\u22652) in: segmented neutrophil of bone marrow (z=4), CD34-negative megakaryocyte cell (z=4), CD8-positive alpha-beta T cell (z=3), CD4-positive alpha-beta T cell (z=3), common lymphoid progenitor (z=3), conventional dendritic cell (z=4), CD4-positive alpha-beta thymocyte (z=5), CD8-positive alpha-beta thymocyte (z=4).\\\\n\\\\n### SMAD3\\\\n\\\\nShows high tissue-specific expression in: CD14-positive, CD16-negative classical monocyte (z=3), with generally lower tissue specificity than SMAD2.\\\\n\\\\n**Implication:** SMAD2's higher expression in immune cells may complicate systemic inhibition due to immunological effects, while SMAD3's broader expression pattern may present different toxicity concerns.\\\\n\\\\n---\\\\n\\\\n## Challenges and Considerations\\\\n\\\\n### 1. Selectivity Between SMAD2 and SMAD3\\\\n\\\\n- High structural similarity (both R-SMADs)\\\\n- Overlapping functions in TGF-\\\\u03b2 signaling\\\\n- Both form SMAD2/SMAD3:SMAD4 heterotrimers\\\\n- Selective inhibition may require exploiting unique interaction surfaces or post-translational modification sites\\\\n\\\\n### 2. Context-Dependent Functions\\\\n\\\\n**Tumor suppressor vs. oncogenic roles:**\\\\n- In early cancer stages: tumor suppressive (inhibition contraindicated)\\\\n- In advanced cancer/metastasis: pro-metastatic (inhibition beneficial)\\\\n- Requires careful patient stratification\\\\n\\\\n### 3. Compensatory Mechanisms\\\\n\\\\nSMAD2 shows phenotypic enhancement with SMAD3, and SMAD3 shows phenotypic enhancement with SMAD2, suggesting functional redundancy that may limit single-target efficacy.\\\\n\\\\n### 4. Nuclear-Cytoplasmic Shuttling\\\\n\\\\n**SMAD2:**\\\\nCytoplasmic and nuclear in the absence of TGF-beta; migrates to nucleus when complexed with SMAD4 or IPO7 upon TGF-beta stimulation; released from complex and exported by RANBP1 upon dephosphorylation by PPM1A.\\\\n\\\\n**SMAD3:**\\\\nShows similar cytoplasmic-nuclear shuttling; migrates to nucleus when complexed with SMAD4; released and exported by RANBP1 through PPM1A action.\\\\n\\\\n**Implication:** Targeting nuclear import/export machinery or phosphatases (PPM1A) could modulate both proteins' activity.\\\\n\\\\n---\\\\n\\\\n## Summary and Recommendations\\\\n\\\\n### Druggability Ranking: SMAD3 > SMAD2\\\\n\\\\n**SMAD3 advantages:**\\\\n1. Validated small molecule inhibitors with nanomolar potency\\\\n2. Established screening assays and chemical starting points\\\\n3. Better characterized in fibrosis (clearer therapeutic indication)\\\\n\\\\n**SMAD2 advantages:**\\\\n1. Ligandable cysteines for covalent inhibitor development\\\\n2. Higher FPocket scores suggesting better pocket druggability\\\\n3. More tissue-restricted expression may reduce off-target effects\\\\n\\\\n### Recommended Targeting Approaches (Priority Order)\\\\n\\\\n1. **SMAD3 direct inhibition** (fibrosis, specific cancers)\\\\n - Build on existing nanomolar inhibitors\\\\n - Optimize for selectivity and pharmacokinetics\\\\n\\\\n2. **SMAD2 covalent inhibition** (cardiovascular, specific cancers)\\\\n - Target ligandable C74 or C81\\\\n - Develop selective covalent warheads\\\\n\\\\n3. **Dual SMAD2/3 PROTACs** (advanced cancers, severe fibrosis)\\\\n - Leverage endogenous E3 ligases (SMURF2, WWP2)\\\\n - Achieve complete pathway blockade\\\\n\\\\n4. **PPI disruption** (SMAD2/3-SMAD4 or co-factor interactions)\\\\n - Target heterotrimer formation\\\\n - Disrupt interactions with CREBBP/EP300\\\\n\\\\n5. **Upstream targeting** (TGF-\\\\u03b2 receptors, activating kinases)\\\\n - Indirect but clinically validated approach\\\\n - Affects both SMAD2 and SMAD3\\\\n\\\\n### Key Unresolved Issues\\\\n\\\\n1. **Selectivity:** Can SMAD2-selective or SMAD3-selective inhibitors be developed given structural similarity?\\\\n2. **Context-dependence:** How to stratify patients for tumor suppressor vs. pro-metastatic contexts?\\\\n3. **Redundancy:** Will single-target inhibition be sufficient or is dual targeting required?\\\\n4. **Biomarkers:** What pharmacodynamic markers can confirm target engagement in vivo?\\\\n5. **Resistance:** Will compensatory upregulation of parallel pathways limit efficacy?\\\\n\\\\n**Possible speculation:**\\\\n\\\\nGiven the existing SMAD3 inhibitors and SMAD2's ligandable cysteines, a rational drug development strategy might involve:\\\\n\\\\n1. **Near-term:** Optimize existing SMAD3 inhibitors for fibrosis indications where the therapeutic rationale is clearest\\\\n2. **Medium-term:** Develop SMAD2-selective covalent inhibitors targeting C74/C81 for cardiovascular indications (Loeys-Dietz syndrome)\\\\n3. **Long-term:** Create bifunctional degraders (PROTACs) for dual SMAD2/3 targeting in advanced cancers where complete pathway blockade is desired\\\\n\\\\nThe higher genetic constraint tolerance and non-essential status of both genes suggest that therapeutic inhibition may be feasible, though careful attention to tissue-specific and context-dependent effects will be critical for safety and efficacy.\\\"\\n },\\n \\\"tool_updates\\\": 2,\\n \\\"used_tools\\\": [\\n \\\"BioGRID\\\",\\n \\\"MSigDB\\\",\\n \\\"chembl\\\",\\n \\\"drug_central\\\",\\n \\\"extract_entities\\\",\\n \\\"prot\\\",\\n \\\"uniprot_base\\\",\\n \\\"BioGRID\\\",\\n \\\"MSigDB\\\",\\n \\\"OpenTargets\\\",\\n \\\"Summarize_GO\\\",\\n \\\"chembl\\\",\\n \\\"drug_central\\\",\\n \\\"extract_entities\\\",\\n \\\"humanbase_functions\\\",\\n \\\"prot\\\",\\n \\\"reactome\\\",\\n \\\"uniprot_base\\\"\\n ],\\n \\\"use_tools\\\": [\\n \\\"extract_entities\\\",\\n \\\"prot\\\",\\n \\\"chembl\\\",\\n \\\"drug_central\\\",\\n \\\"MSigDB\\\",\\n \\\"uniprot_base\\\",\\n \\\"BioGRID\\\",\\n \\\"OpenTargets\\\",\\n \\\"reactome\\\",\\n \\\"humanbase_functions\\\",\\n \\\"Summarize_GO\\\"\\n ],\\n \\\"ui\\\": {\\n \\\"run_id\\\": \\\"20251224-191245_ui\\\",\\n \\\"artifact_base\\\": \\\"/runs/20251224-191245_ui/\\\"\\n },\\n \\\"prot_html\\\": \\\"\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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�85\\u0005��ͣ\\u000e\\u001eϡ֩B��\\\"����SR��c·�an���v�X�P��U�Z(�ZX�����9�PԨ^�bE=.^������i!ג������!f��\\u0006�Zz�̪\\u0019�\\u001a#�B����Ӻs��Ti��\\f]4C\\u000b��W\\u000fG<�\\u0016U��+13�ʼn)A\\u000f�\\b�yy1�V3\\u0007\\u000b�\\u000f\\u0004�~o�M��dB\\u0013�j�������\\u001e\\u0013��\\u0018^ou��3\\u0003S%T�z\\\\\\u001bi�����\\u000fQu�:y5�\\\"l@W��\\u000e�\\n\\u000e�O,doƍn�q���/�(J�{z)3�o3��\\u0011�\\u0011!��}LI��Y�8�Bɂ���\\u0005?���L@e���E�A,{Su>:;�i������D�B�\\u0010m�\\\"#\\u0014 e����(z�6%%2J�EݭR�!�*�T� �\\\\5B)���p*�\\u0016\\u001a\\u0001%�\\u0010zh�$Ufb&p�4oڇ\\u001f��-\\u0001O\\u0012�<��\\u0016��*���%�\\\\W #�t�P\\u0002h$���&@u��*�\\f�\\\"����\\t\\u0004�T�q��\\u0017�\\u0018�\\n��)3\\u000bQ��\\u00165[�c$gV�s�r\\u0019.��̓\\u0015��\\\\�W����r\\u0019^].ë�\\u0001`��\\u0000\\u0000\\u0000\\u0007IDATe�\\u000f\\u0000\\u0000���6E!\\u0000\\u0000\\u0000\\u0006IDAT\\u0003\\u0000TX����D�\\u0000\\u0000\\u0000\\u0000IEND�B`�\"],[\"20251224-191245_ui/demo.log\",\"=== START: Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues ===\\n[TOOL SELECTION PROMPT] You are an assistant deciding which tools to use to answer a biomedical question. User question: \\\"\\\"\\\"Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues\\\"\\\"\\\" \\n\\n If the question mentioned a database or tool and we do not have it, use the most similar available ones. If there are multiple tools with complementary or similar information, you are allowed to use complementary tools. However, avoid calling tools that create long context unless needed to answer the question. Try to get as much relevant information as possible. Available tools: - extract_entities: Extract genes and biomedical entities from the user question. This must run before any downstream tool to populate gene/trait context.\\n- aa_seq: Resolve amino acid sequences (not gene symbols) to UniProt and gene-level information using a local copy of the UniProt database. The tool updates per-gene text summaries and returns both a structured result, a global text summary, and an interactive HTML viewer for AA-sequence mappings.\\n- AllianceOfGenomes: Fetches species-specific gene summary descriptions from the Alliance of Genome Resources, a consortium integrating curated data from major model organism databases for yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans), fruit fly (Drosophila melanogaster), zebrafish (Danio rerio), mouse (Mus musculus), rat (Rattus norvegicus), and frog (Xenopus species). The returned summaries provide high-level functional and biological context for the input genes across available model organisms (for example, core molecular function, conserved biological roles, and representative phenotypes described in model systems).\\n- alphamissense: Fetches Alphamissense predicted pathogenicity classes for given variants. This requires variant_annotations to be run first.\\n- BioGRID: Fetches gene interactions from BioGRID for the input genes. Provides a curated context-specific list of protein-protein, genetic and chemical interactions.\\n- chembl: Query ChEMBL for drug-target information about one or more genes, finding whether there are any drugs targeting this gene and their status. Specifically, this tool summarizes FDA-approved drugs (with black-box, withdrawn, indication, MoA), clinical and preclinical trials, and assay bioactivity data. Generates text summaries and an interactive HTML viewer with 2D molecular renderings.\\n- clinvar_gene_node: Annotates genes with ClinVar gene–disease associations (disease name, source, last updated). \\n- clinvar_variants_node: Retrieves pathogenic and likely pathogenic variants for input genes (rsID, variant type, name, clinical significance) from the ClinVar database. Should only be called if exact variant information such as amino acid substitution or variant ID is required to answer the question, otherwise use ClinVar gene-level. Might create excessively long context for commonly implicated genes.\\n- variant_annotations: Annotate existing variants with dbSNP coordinates and context required by downstream nodes.\\n- variant_population_summaries: Extend dbSNP annotations with population frequency summaries for each variant. Useful for characterizing the frequency of variants in the population.\\n- DisGeNet: Fetches information about disease annotations for the input genes from DisGeNet, which provides curated data linking human genes to a wide range of diseases, including Mendelian, complex, environmental, and rare diseases.\\n- drug_central: Query Drug Central for drug-centric information given one or more drugs identified by name, synonym, ChEMBL ID, CAS number, struct_id, or external IDs. Summarizes drug description, information, structural properties, regulatory status, pharmacologic actions, HUMAN gene-level targets (MoA and off-target), indications, contraindications, FAERS safety signals, and cross references, with text summaries and an optional interactive HTML viewer.\\n- gencode_gene_node: Annotate genes with GENCODE metadata (transcripts, spans, gene type, number of exons). Essential for many downstream analyses.\\n- Summarize_GO: Summarizes GO terms for the input genes, to condense long list into representative terms.\\n- Summarize_bioGRID_GO: This is a summarized version of BIOGRID that queries BioGRID but returns summarized GO enrichment rather than individual interactors. Use when individual interactor names are not needed or a summary of interactions would be helpful to answer the query. Provides a summarized list of GO terms significantly enriched for the interacting genes of each input gene fetched from BioGRID.\\n- query_gwas_by_gene: Retrieves genome-wide association study (GWAS) results for a given gene. It collects traits and diseases associated with genetic variants linked to that gene, along with the specific variants\\n- query_gwas_extensive: This is a more comprehensive version of the query_gwas_by_gene tool, and it is used to retrieve more detailed information about the GWAS results. It collects an extensive list of traits/diseases associated with an extensive list of genetic variants linked to that gene. Use this tool *ONLY* if the question is very specific that requires what is equivalent to an extensive database search, not to general characterisation of the gene.\\n- humanbase_functions: Fetch per-gene functional predictions from HumanBase tissue-specific networks. Provides expanded list of functions.\\n- expectosc_predictions_agent: Annotates variants with predicted (from sequence) cell type-specific expression disruption predictions. Requires variant_annotations to be run first\\n- intact_viral: Fetches curated host–virus molecular interactions from the IntAct Virus dataset, reporting experimentally supported protein–protein interactions between host genes/proteins and viral proteins, with organism and taxon context for each interactor.\\n- miRDB: Looks up predicted target genes for the miRNA of interest using miRDB, with organism-specific predictions.\\n- MSigDB: Fetches MSigDB annotations for input genes across collections (H, C1–C8), including hallmark biological processes, positional cytogenetic bands per gene, curated pathways, regulatory target information (e.g. transcription-factor binding in promoter region of the gene and miRNAs predicted to target this gene), computational signatures from cancer-oriented expression data, oncogenic signatures of pathways dysregulated in cancer, immunologic signatures, and cell-type markers.\\n- OMIM: Fetches curated OMIM entries describing Mendelian disease phenotypes caused by pathogenic variants in the input genes, including clinical features, inheritance patterns, and molecular genetic evidence.\\n- OpenTargets: Fetches target-disease associations, tissue-specific expression, essentiality, genetic constraint for synonymous, missense, and loss-of-function variants, associations between target genes and drug-induced adverse effects, and variant to drug response associations from Open Targets for the input genes.\\n- prot: Visualize AlphaFold-predicted protein structures for one or more genes. Overlays include: per-residue confidence scores (pLDDT, AlphaFold); pocket druggability and geometric features (FPocket); solvent-accessible surface area and polarity index (FreeSASA); intrinsic disorder consensus (IUPred3 + DisProt); MoRF propensity predictions (IUPred3/ANCHOR2); ligand-binding evidence (BioLiP2 + ChEMBL); and cysteine chemoproteomics annotations from CysDB, including detected, ligandable, hyperreactive, and active-site or binding-site–proximal cysteines. Generates interactive 3Dmol.js views with color-coded surfaces, binding-site context, summary statistics, and interpretation notes.\\n- reactome: Fetches Reactome pathways associated with the input genes, providing curated, expert-reviewed pathway information that describe molecular interactions, signaling cascades, and biological processes in which the genes participate.\\n- remap_crm_agent: Fetches cis-regulatory modules (CRMs) from the ReMap 2022 database that are proximal to the transcription start site (TSS) of the input genes. Reports transcription factors with supporting ChIP-seq binding evidence overlapping these regions. Requires GENCODE annotation (gencode_gene_node) to be run first. Useful for exploratory analysis of potential transcriptional regulatory contexts.\\n- sei: Fetches predictions of the sequence regulatory activity for given variants. This requires variant_annotations to be run first.\\n- uniprot_base: Fetch UniProt entries for genes, extracting diseases, GO terms, and isoform annotations. Helps to expand the base annotations.\\n- uniprot_gwas: Fetch UniProt entries for genes, extracting diseases, GO terms, and isoform annotations. Helps to expand the base annotations..\\n\\n Examples selection and outputs: EXAMPLE PIPELINES (pay attention to dependencies):\\n\\n1. Variant regulatory activity:\\n [\\\"extract_entities\\\", \\\"gencode_gene_node\\\", \\\"query_gwas_by_gene\\\", \\\"variant_annotations\\\", \\\"sei\\\", \\\"expectosc_predictions_agent\\\", \\\"remap_crm_agent\\\"]\\n\\n2. Variant pathogenicity:\\n [\\\"extract_entities\\\", \\\"query_gwas_by_gene\\\", \\\"variant_annotations\\\", \\\"alphamissense\\\"] \\n\\n3. Gene-level functional annotation:\\n [\\\"extract_entities\\\", \\\"gencode_gene_node\\\", \\\"humanbase_functions\\\", \\\"uniprot_base\\\", \\\"reactome\\\", \\\"Summarize_bioGRID_GO\\\", \\\"uniprot_gwas\\\", 'clinvar_gene_node']\\n\\n4. Protein structure, visualization and druggability:\\n [\\\"extract_entities\\\", \\\"prot\\\", \\\"chembl\\\", \\\"drug_central\\\", \\\"MSigDB\\\"]\\n \\n5. Protein-protein interactions and gene function questions summaries: \\n [\\\"extract_entities\\\", \\\"Summarize_bioGRID_GO\\\", \\\"Summarize_GO\\\", \\\"AllianceOfGenomes\\\"]\\n \\n6. Specific protein-protein interactions and gene function questions: \\n [\\\"extract_entities\\\", \\\"BioGRID\\\", \\\"reactome\\\", \\\"intact_viral\\\"]\\n \\nNote these are only examples, and in real life you may need to run combinations of these tools **depending on the user intent and the entities extracted**.\\n\\nRespond *ONLY* with a Python list of tool names. Example: [\\\"humanbase_functions\\\", \\\"uniprot_base\\\"] or [\\\"humanbase_functions\\\", \\\"uniprot_base\\\", \\\"query_gwas_by_gene\\\"] or [\\\"query_gwas_by_gene\\\", \\\"BioGRID\\\"]\\n\\nDo not include any explanations or extra text outside the list.\\n\\n[TOOL SELECTION RESPONSE][claude-sonnet-4-5-20250929] Message(id='msg_01Rj8V9Za2wKL8WeRzWkXhnm', content=[TextBlock(citations=None, text='[\\\"extract_entities\\\", \\\"prot\\\", \\\"chembl\\\", \\\"drug_central\\\", \\\"MSigDB\\\", \\\"uniprot_base\\\", \\\"BioGRID\\\"]', type='text')], model='claude-sonnet-4-5-20250929', role='assistant', stop_reason='end_turn', stop_sequence=None, type='message', usage=Usage(cache_creation_input_tokens=0, cache_read_input_tokens=0, input_tokens=2474, output_tokens=40, server_tool_use=None, service_tier='standard', cache_creation={'ephemeral_5m_input_tokens': 0, 'ephemeral_1h_input_tokens': 0}))\\n[TOOL SELECTION] Selected tools: ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID']\\n[TOOL INVOKE] Selected tools: ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID']\\n[TOOL INVOKE] Already used tools: []\\n*NAME* extract_entities\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': [], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 0, 'used_tools': [], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID'], 'ui': {}, 'prot_html': '', 'chembl_html': '', 'drug_central_html': '', 'aa_seq_html': '', 'text_notes': []}\\n[TOOL RUN] → extract_entities\\n[_extract_entities_with_claude] Found: {'genes': ['SMAD3', 'SMAD2'], 'traits': [], 'drugs': []}\\n[_get_flair_model] Loaded FLAIR model: hunflair2\\n[_extract_entities_with_flair] Found: {'genes': ['SMAD3', 'SMAD2'], 'proteins': []}\\n\\rFetching 5 files: 0%| | 0/5 [00:0090 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.'], tools_run=['EntityExtraction'])}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 0, 'used_tools': ['prot'], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID'], 'ui': {}, 'prot_html': '\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
    \\\\n \\\\n
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    \\\\n Min\\\\n \\\\n Max\\\\n
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    \\\\n \\\\n CysDB:\\\\n \\\\n\\\\n [\\\\n\\\\n \\\\n \\\\n\\\\n |\\\\n\\\\n \\\\n \\\\n\\\\n |\\\\n\\\\n \\\\n \\\\n\\\\n |\\\\n\\\\n \\\\n Cys @ Act. Site\\\\n \\\\n or Near\\\\n \\\\n\\\\n |\\\\n\\\\n \\\\n Cys @ Bind. Site\\\\n \\\\n or Near\\\\n \\\\n\\\\n ]\\\\n
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0.2626}, {'residue_no': 442, 'score': 0.2763}, {'residue_no': 443, 'score': 0.2901}, {'residue_no': 444, 'score': 0.309}, {'residue_no': 445, 'score': 0.3256}, {'residue_no': 446, 'score': 0.3503}, {'residue_no': 447, 'score': 0.3709}, {'residue_no': 448, 'score': 0.3892}, {'residue_no': 449, 'score': 0.3975}, {'residue_no': 450, 'score': 0.3966}, {'residue_no': 451, 'score': 0.4017}, {'residue_no': 452, 'score': 0.4071}, {'residue_no': 453, 'score': 0.3969}, {'residue_no': 454, 'score': 0.3797}, {'residue_no': 455, 'score': 0.3604}, {'residue_no': 456, 'score': 0.3548}, {'residue_no': 457, 'score': 0.3354}, {'residue_no': 458, 'score': 0.3188}, {'residue_no': 459, 'score': 0.3052}, {'residue_no': 460, 'score': 0.3007}, {'residue_no': 461, 'score': 0.3061}, {'residue_no': 462, 'score': 0.2966}, {'residue_no': 463, 'score': 0.2923}, {'residue_no': 464, 'score': 0.2943}, {'residue_no': 465, 'score': 0.3023}, {'residue_no': 466, 'score': 0.3118}, {'residue_no': 467, 'score': 0.306}], 'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 2 (Q15796) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 467 UNP Q15796 SMAD2_HUMAN 1 467 \\\\nSEQRES 1 A 467 MET SER SER ILE LEU PRO PHE THR PRO PRO VAL VAL LYS \\\\nSEQRES 2 A 467 ARG LEU LEU GLY TRP LYS LYS SER ALA GLY GLY SER GLY \\\\nSEQRES 3 A 467 GLY ALA GLY GLY GLY GLU GLN ASN GLY GLN GLU GLU LYS \\\\nSEQRES 4 A 467 TRP CYS GLU LYS ALA VAL LYS SER LEU VAL LYS LYS LEU \\\\nSEQRES 5 A 467 LYS LYS THR GLY ARG LEU ASP GLU LEU GLU LYS ALA ILE \\\\nSEQRES 6 A 467 THR THR GLN ASN CYS ASN THR LYS CYS VAL THR ILE PRO \\\\nSEQRES 7 A 467 SER THR CYS SER GLU ILE TRP GLY LEU SER THR PRO ASN \\\\nSEQRES 8 A 467 THR ILE ASP GLN TRP ASP THR THR GLY LEU TYR SER PHE \\\\nSEQRES 9 A 467 SER GLU GLN THR ARG SER LEU ASP GLY ARG LEU GLN VAL \\\\nSEQRES 10 A 467 SER HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG \\\\nSEQRES 11 A 467 LEU TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU \\\\nSEQRES 12 A 467 LYS ALA ILE GLU ASN CYS GLU TYR ALA PHE ASN LEU LYS \\\\nSEQRES 13 A 467 LYS ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG \\\\nSEQRES 14 A 467 VAL GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG \\\\nSEQRES 15 A 467 HIS THR GLU ILE LEU THR GLU LEU PRO PRO LEU ASP ASP \\\\nSEQRES 16 A 467 TYR THR HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA \\\\nSEQRES 17 A 467 GLY ILE GLU PRO GLN SER ASN TYR ILE PRO GLU THR PRO \\\\nSEQRES 18 A 467 PRO PRO GLY TYR ILE SER GLU ASP GLY GLU THR SER ASP \\\\nSEQRES 19 A 467 GLN GLN LEU ASN GLN SER MET ASP THR GLY SER PRO ALA \\\\nSEQRES 20 A 467 GLU LEU SER PRO THR THR LEU SER PRO VAL ASN HIS SER \\\\nSEQRES 21 A 467 LEU ASP LEU GLN PRO VAL THR TYR SER GLU PRO ALA PHE \\\\nSEQRES 22 A 467 TRP CYS SER ILE ALA TYR TYR GLU LEU ASN GLN ARG VAL \\\\nSEQRES 23 A 467 GLY GLU THR PHE HIS ALA SER GLN PRO SER LEU THR VAL \\\\nSEQRES 24 A 467 ASP GLY PHE THR ASP PRO SER ASN SER GLU ARG PHE CYS \\\\nSEQRES 25 A 467 LEU GLY LEU LEU SER ASN VAL ASN ARG ASN ALA THR VAL \\\\nSEQRES 26 A 467 GLU MET THR ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU \\\\nSEQRES 27 A 467 TYR TYR ILE GLY GLY GLU VAL PHE ALA GLU CYS LEU SER \\\\nSEQRES 28 A 467 ASP SER ALA ILE PHE VAL GLN SER PRO ASN CYS ASN GLN \\\\nSEQRES 29 A 467 ARG TYR GLY TRP HIS PRO ALA THR VAL CYS LYS ILE PRO \\\\nSEQRES 30 A 467 PRO GLY CYS ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE \\\\nSEQRES 31 A 467 ALA ALA LEU LEU ALA GLN SER VAL ASN GLN GLY PHE GLU \\\\nSEQRES 32 A 467 ALA VAL TYR GLN LEU THR ARG MET CYS THR ILE ARG MET \\\\nSEQRES 33 A 467 SER PHE VAL LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN \\\\nSEQRES 34 A 467 THR VAL THR SER THR PRO CYS TRP ILE GLU LEU HIS LEU \\\\nSEQRES 35 A 467 ASN GLY PRO LEU GLN TRP LEU ASP LYS VAL LEU THR GLN \\\\nSEQRES 36 A 467 MET GLY SER PRO SER VAL ARG CYS SER SER MET SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 -24.572 -42.101 26.586 1.00 40.65 N \\\\nATOM 2 CA MET A 1 -23.660 -40.986 26.918 1.00 40.65 C \\\\nATOM 3 C MET A 1 -24.312 -39.697 26.444 1.00 40.65 C \\\\nATOM 4 CB MET A 1 -22.280 -41.179 26.264 1.00 40.65 C \\\\nATOM 5 O MET A 1 -24.227 -39.375 25.268 1.00 40.65 O \\\\nATOM 6 CG MET A 1 -21.477 -42.313 26.910 1.00 40.65 C \\\\nATOM 7 SD MET A 1 -19.880 -42.579 26.105 1.00 40.65 S \\\\nATOM 8 CE MET A 1 -19.199 -43.908 27.135 1.00 40.65 C \\\\nATOM 9 N SER A 2 -25.061 -39.026 27.318 1.00 40.07 N \\\\nATOM 10 CA SER A 2 -25.762 -37.787 26.974 1.00 40.07 C \\\\nATOM 11 C SER A 2 -24.744 -36.657 26.853 1.00 40.07 C \\\\nATOM 12 CB SER A 2 -26.833 -37.463 28.023 1.00 40.07 C \\\\nATOM 13 O SER A 2 -24.164 -36.225 27.847 1.00 40.07 O \\\\nATOM 14 OG SER A 2 -27.659 -38.600 28.207 1.00 40.07 O \\\\nATOM 15 N SER A 3 -24.488 -36.213 25.627 1.00 41.96 N \\\\nATOM 16 CA SER A 3 -23.669 -35.042 25.327 1.00 41.96 C \\\\nATOM 17 C SER A 3 -24.297 -33.802 25.968 1.00 41.96 C \\\\nATOM 18 CB SER A 3 -23.571 -34.885 23.804 1.00 41.96 C \\\\nATOM 19 O SER A 3 -25.347 -33.334 25.529 1.00 41.96 O \\\\nATOM 20 OG SER A 3 -24.856 -34.989 23.221 1.00 41.96 O \\\\nATOM 21 N ILE A 4 -23.663 -33.281 27.020 1.00 49.09 N \\\\nATOM 22 CA ILE A 4 -24.019 -32.004 27.645 1.00 49.09 C \\\\nATOM 23 C ILE A 4 -23.817 -30.914 26.587 1.00 49.09 C \\\\nATOM 24 CB ILE A 4 -23.162 -31.774 28.918 1.00 49.09 C \\\\nATOM 25 O ILE A 4 -22.683 -30.590 26.230 1.00 49.09 O \\\\nATOM 26 CG1 ILE A 4 -23.467 -32.865 29.975 1.00 49.09 C \\\\nATOM 27 CG2 ILE A 4 -23.401 -30.371 29.509 1.00 49.09 C \\\\nATOM 28 CD1 ILE A 4 -22.507 -32.870 31.172 1.00 49.09 C \\\\nATOM 29 N LEU A 5 -24.914 -30.374 26.051 1.00 54.35 N \\\\nATOM 30 CA LEU A 5 -24.866 -29.217 25.160 1.00 54.35 C \\\\nATOM 31 C LEU A 5 -24.174 -28.057 25.901 1.00 54.35 C \\\\nATOM 32 CB LEU A 5 -26.287 -28.820 24.715 1.00 54.35 C \\\\nATOM 33 O LEU A 5 -24.526 -27.781 27.052 1.00 54.35 O \\\\nATOM 34 CG LEU A 5 -26.968 -29.818 23.758 1.00 54.35 C \\\\nATOM 35 CD1 LEU A 5 -28.438 -29.436 23.583 1.00 54.35 C \\\\nATOM 36 CD2 LEU A 5 -26.309 -29.824 22.376 1.00 54.35 C \\\\nATOM 37 N PRO A 6 -23.190 -27.372 25.292 1.00 60.96 N \\\\nATOM 38 CA PRO A 6 -22.455 -26.309 25.964 1.00 60.96 C \\\\nATOM 39 C PRO A 6 -23.410 -25.182 26.380 1.00 60.96 C \\\\nATOM 40 CB PRO A 6 -21.373 -25.863 24.972 1.00 60.96 C \\\\nATOM 41 O PRO A 6 -24.093 -24.583 25.551 1.00 60.96 O \\\\nATOM 42 CG PRO A 6 -21.914 -26.299 23.609 1.00 60.96 C \\\\nATOM 43 CD PRO A 6 -22.720 -27.553 23.930 1.00 60.96 C \\\\nATOM 44 N PHE A 7 -23.456 -24.883 27.680 1.00 70.11 N \\\\nATOM 45 CA PHE A 7 -24.301 -23.825 28.228 1.00 70.11 C \\\\nATOM 46 C PHE A 7 -23.821 -22.449 27.741 1.00 70.11 C \\\\nATOM 47 CB PHE A 7 -24.316 -23.929 29.761 1.00 70.11 C \\\\nATOM 48 O PHE A 7 -22.785 -21.940 28.176 1.00 70.11 O \\\\nATOM 49 CG PHE A 7 -25.218 -22.917 30.448 1.00 70.11 C \\\\nATOM 50 CD1 PHE A 7 -24.682 -21.724 30.971 1.00 70.11 C \\\\nATOM 51 CD2 PHE A 7 -26.594 -23.180 30.586 1.00 70.11 C \\\\nATOM 52 CE1 PHE A 7 -25.515 -20.804 31.634 1.00 70.11 C \\\\nATOM 53 CE2 PHE A 7 -27.427 -22.259 31.246 1.00 70.11 C \\\\nATOM 54 CZ PHE A 7 -26.888 -21.073 31.773 1.00 70.11 C \\\\nATOM 55 N THR A 8 -24.572 -21.829 26.831 1.00 74.66 N \\\\nATOM 56 CA THR A 8 -24.329 -20.445 26.401 1.00 74.66 C \\\\nATOM 57 C THR A 8 -25.030 -19.480 27.363 1.00 74.66 C \\\\nATOM 58 CB THR A 8 -24.728 -20.221 24.936 1.00 74.66 C \\\\nATOM 59 O THR A 8 -26.260 -19.534 27.459 1.00 74.66 O \\\\nATOM 60 CG2 THR A 8 -24.478 -18.787 24.475 1.00 74.66 C \\\\nATOM 61 OG1 THR A 8 -23.883 -21.048 24.178 1.00 74.66 O \\\\nATOM 62 N PRO A 9 -24.291 -18.587 28.061 1.00 81.38 N \\\\nATOM 63 CA PRO A 9 -24.875 -17.665 29.034 1.00 81.38 C \\\\nATOM 64 C PRO A 9 -26.022 -16.833 28.430 1.00 81.38 C \\\\nATOM 65 CB PRO A 9 -23.725 -16.765 29.501 1.00 81.38 C \\\\nATOM 66 O PRO A 9 -25.880 -16.379 27.291 1.00 81.38 O \\\\nATOM 67 CG PRO A 9 -22.486 -17.630 29.288 1.00 81.38 C \\\\nATOM 68 CD PRO A 9 -22.839 -18.444 28.047 1.00 81.38 C \\\\nATOM 69 N PRO A 10 -27.113 -16.546 29.170 1.00 88.04 N \\\\nATOM 70 CA PRO A 10 -28.265 -15.803 28.643 1.00 88.04 C \\\\nATOM 71 C PRO A 10 -27.903 -14.455 28.006 1.00 88.04 C \\\\nATOM 72 CB PRO A 10 -29.206 -15.617 29.838 1.00 88.04 C \\\\nATOM 73 O PRO A 10 -28.428 -14.103 26.954 1.00 88.04 O \\\\nATOM 74 CG PRO A 10 -28.904 -16.831 30.714 1.00 88.04 C \\\\nATOM 75 CD PRO A 10 -27.408 -17.050 30.507 1.00 88.04 C \\\\nATOM 76 N VAL A 11 -26.942 -13.728 28.587 1.00 89.17 N \\\\nATOM 77 CA VAL A 11 -26.420 -12.472 28.018 1.00 89.17 C \\\\nATOM 78 C VAL A 11 -25.778 -12.654 26.641 1.00 89.17 C \\\\nATOM 79 CB VAL A 11 -25.444 -11.785 28.991 1.00 89.17 C \\\\nATOM 80 O VAL A 11 -25.989 -11.835 25.755 1.00 89.17 O \\\\nATOM 81 CG1 VAL A 11 -24.266 -12.670 29.436 1.00 89.17 C \\\\nATOM 82 CG2 VAL A 11 -24.874 -10.512 28.374 1.00 89.17 C \\\\nATOM 83 N VAL A 12 -25.047 -13.750 26.421 1.00 90.18 N \\\\nATOM 84 CA VAL A 12 -24.426 -14.037 25.121 1.00 90.18 C \\\\nATOM 85 C VAL A 12 -25.511 -14.301 24.081 1.00 90.18 C \\\\nATOM 86 CB VAL A 12 -23.450 -15.222 25.221 1.00 90.18 C \\\\nATOM 87 O VAL A 12 -25.415 -13.779 22.976 1.00 90.18 O \\\\nATOM 88 CG1 VAL A 12 -22.897 -15.653 23.860 1.00 90.18 C \\\\nATOM 89 CG2 VAL A 12 -22.261 -14.884 26.131 1.00 90.18 C \\\\nATOM 90 N LYS A 13 -26.567 -15.046 24.443 1.00 90.09 N \\\\nATOM 91 CA LYS A 13 -27.716 -15.269 23.551 1.00 90.09 C \\\\nATOM 92 C LYS A 13 -28.409 -13.955 23.179 1.00 90.09 C \\\\nATOM 93 CB LYS A 13 -28.730 -16.246 24.165 1.00 90.09 C \\\\nATOM 94 O LYS A 13 -28.685 -13.747 22.005 1.00 90.09 O \\\\nATOM 95 CG LYS A 13 -28.180 -17.668 24.349 1.00 90.09 C \\\\nATOM 96 CD LYS A 13 -29.318 -18.629 24.722 1.00 90.09 C \\\\nATOM 97 CE LYS A 13 -28.790 -20.054 24.924 1.00 90.09 C \\\\nATOM 98 NZ LYS A 13 -29.892 -21.005 25.223 1.00 90.09 N \\\\nATOM 99 N ARG A 14 -28.629 -13.054 24.148 1.00 91.11 N \\\\nATOM 100 CA ARG A 14 -29.205 -11.720 23.892 1.00 91.11 C \\\\nATOM 101 C ARG A 14 -28.332 -10.898 22.938 1.00 91.11 C \\\\nATOM 102 CB ARG A 14 -29.461 -10.958 25.206 1.00 91.11 C \\\\nATOM 103 O ARG A 14 -28.825 -10.440 21.917 1.00 91.11 O \\\\nATOM 104 CG ARG A 14 -30.632 -11.542 26.016 1.00 91.11 C \\\\nATOM 105 CD ARG A 14 -31.021 -10.655 27.210 1.00 91.11 C \\\\nATOM 106 NE ARG A 14 -29.967 -10.579 28.245 1.00 91.11 N \\\\nATOM 107 NH1 ARG A 14 -30.351 -8.417 28.976 1.00 91.11 N \\\\nATOM 108 NH2 ARG A 14 -28.636 -9.524 29.765 1.00 91.11 N \\\\nATOM 109 CZ ARG A 14 -29.674 -9.525 28.994 1.00 91.11 C \\\\nATOM 110 N LEU A 15 -27.028 -10.803 23.213 1.00 92.52 N \\\\nATOM 111 CA LEU A 15 -26.075 -10.061 22.377 1.00 92.52 C \\\\nATOM 112 C LEU A 15 -25.955 -10.606 20.948 1.00 92.52 C \\\\nATOM 113 CB LEU A 15 -24.703 -10.023 23.065 1.00 92.52 C \\\\nATOM 114 O LEU A 15 -25.822 -9.822 20.009 1.00 92.52 O \\\\nATOM 115 CG LEU A 15 -24.615 -9.069 24.270 1.00 92.52 C \\\\nATOM 116 CD1 LEU A 15 -23.259 -9.267 24.947 1.00 92.52 C \\\\nATOM 117 CD2 LEU A 15 -24.711 -7.596 23.880 1.00 92.52 C \\\\nATOM 118 N LEU A 16 -26.018 -11.929 20.780 1.00 91.58 N \\\\nATOM 119 CA LEU A 16 -26.069 -12.567 19.463 1.00 91.58 C \\\\nATOM 120 C LEU A 16 -27.408 -12.329 18.751 1.00 91.58 C \\\\nATOM 121 CB LEU A 16 -25.795 -14.073 19.608 1.00 91.58 C \\\\nATOM 122 O LEU A 16 -27.421 -12.254 17.529 1.00 91.58 O \\\\nATOM 123 CG LEU A 16 -24.336 -14.414 19.952 1.00 91.58 C \\\\nATOM 124 CD1 LEU A 16 -24.237 -15.887 20.345 1.00 91.58 C \\\\nATOM 125 CD2 LEU A 16 -23.386 -14.167 18.776 1.00 91.58 C \\\\nATOM 126 N GLY A 17 -28.506 -12.153 19.491 1.00 90.58 N \\\\nATOM 127 CA GLY A 17 -29.823 -11.820 18.939 1.00 90.58 C \\\\nATOM 128 C GLY A 17 -29.896 -10.443 18.269 1.00 90.58 C \\\\nATOM 129 O GLY A 17 -30.723 -10.244 17.387 1.00 90.58 O \\\\nATOM 130 N TRP A 18 -29.005 -9.510 18.625 1.00 91.39 N \\\\nATOM 131 CA TRP A 18 -28.865 -8.217 17.938 1.00 91.39 C \\\\nATOM 132 C TRP A 18 -27.843 -8.234 16.792 1.00 91.39 C \\\\nATOM 133 CB TRP A 18 -28.548 -7.112 18.953 1.00 91.39 C \\\\nATOM 134 O TRP A 18 -27.576 -7.184 16.202 1.00 91.39 O \\\\nATOM 135 CG TRP A 18 -29.603 -6.871 19.988 1.00 91.39 C \\\\nATOM 136 CD1 TRP A 18 -30.872 -6.473 19.747 1.00 91.39 C \\\\nATOM 137 CD2 TRP A 18 -29.499 -6.995 21.436 1.00 91.39 C \\\\nATOM 138 CE2 TRP A 18 -30.766 -6.701 22.015 1.00 91.39 C \\\\nATOM 139 CE3 TRP A 18 -28.444 -7.289 22.320 1.00 91.39 C \\\\nATOM 140 NE1 TRP A 18 -31.560 -6.364 20.941 1.00 91.39 N \\\\nATOM 141 CH2 TRP A 18 -29.924 -7.101 24.250 1.00 91.39 C \\\\nATOM 142 CZ2 TRP A 18 -30.987 -6.753 23.399 1.00 91.39 C \\\\nATOM 143 CZ3 TRP A 18 -28.652 -7.369 23.711 1.00 91.39 C \\\\nATOM 144 N LYS A 19 -27.241 -9.392 16.475 1.00 91.72 N \\\\nATOM 145 CA LYS A 19 -26.306 -9.514 15.351 1.00 91.72 C \\\\nATOM 146 C LYS A 19 -27.019 -9.139 14.049 1.00 91.72 C \\\\nATOM 147 CB LYS A 19 -25.718 -10.938 15.266 1.00 91.72 C \\\\nATOM 148 O LYS A 19 -28.107 -9.635 13.766 1.00 91.72 O \\\\nATOM 149 CG LYS A 19 -24.561 -11.002 14.256 1.00 91.72 C \\\\nATOM 150 CD LYS A 19 -23.988 -12.398 13.957 1.00 91.72 C \\\\nATOM 151 CE LYS A 19 -24.732 -13.086 12.796 1.00 91.72 C \\\\nATOM 152 NZ LYS A 19 -23.912 -14.127 12.109 1.00 91.72 N \\\\nATOM 153 N LYS A 20 -26.391 -8.297 13.232 1.00 89.42 N \\\\nATOM 154 CA LYS A 20 -26.866 -8.016 11.872 1.00 89.42 C \\\\nATOM 155 C LYS A 20 -26.457 -9.165 10.944 1.00 89.42 C \\\\nATOM 156 CB LYS A 20 -26.344 -6.646 11.412 1.00 89.42 C \\\\nATOM 157 O LYS A 20 -25.346 -9.681 11.042 1.00 89.42 O \\\\nATOM 158 CG LYS A 20 -26.864 -5.469 12.253 1.00 89.42 C \\\\nATOM 159 CD LYS A 20 -28.377 -5.244 12.136 1.00 89.42 C \\\\nATOM 160 CE LYS A 20 -28.752 -3.968 12.896 1.00 89.42 C \\\\nATOM 161 NZ LYS A 20 -30.202 -3.672 12.787 1.00 89.42 N \\\\nATOM 162 N SER A 21 -27.358 -9.582 10.060 1.00 76.73 N \\\\nATOM 163 CA SER A 21 -27.071 -10.613 9.052 1.00 76.73 C \\\\nATOM 164 C SER A 21 -26.585 -9.953 7.766 1.00 76.73 C \\\\nATOM 165 CB SER A 21 -28.301 -11.487 8.791 1.00 76.73 C \\\\nATOM 166 O SER A 21 -27.132 -8.922 7.375 1.00 76.73 O \\\\nATOM 167 OG SER A 21 -28.651 -12.154 9.990 1.00 76.73 O \\\\nATOM 168 N ALA A 22 -25.577 -10.531 7.110 1.00 64.94 N \\\\nATOM 169 CA ALA A 22 -25.187 -10.124 5.764 1.00 64.94 C \\\\nATOM 170 C ALA A 22 -26.336 -10.489 4.805 1.00 64.94 C \\\\nATOM 171 CB ALA A 22 -23.856 -10.800 5.410 1.00 64.94 C \\\\nATOM 172 O ALA A 22 -26.600 -11.663 4.556 1.00 64.94 O \\\\nATOM 173 N GLY A 23 -27.108 -9.492 4.371 1.00 48.74 N \\\\nATOM 174 CA GLY A 23 -28.290 -9.689 3.538 1.00 48.74 C \\\\nATOM 175 C GLY A 23 -27.919 -10.007 2.093 1.00 48.74 C \\\\nATOM 176 O GLY A 23 -27.514 -9.117 1.356 1.00 48.74 O \\\\nATOM 177 N GLY A 24 -28.113 -11.264 1.698 1.00 39.25 N \\\\nATOM 178 CA GLY A 24 -28.194 -11.733 0.318 1.00 39.25 C \\\\nATOM 179 C GLY A 24 -29.205 -12.877 0.266 1.00 39.25 C \\\\nATOM 180 O GLY A 24 -29.023 -13.914 0.899 1.00 39.25 O \\\\nATOM 181 N SER A 25 -30.318 -12.649 -0.416 1.00 33.12 N \\\\nATOM 182 CA SER A 25 -31.419 -13.586 -0.628 1.00 33.12 C \\\\nATOM 183 C SER A 25 -30.967 -14.913 -1.254 1.00 33.12 C \\\\nATOM 184 CB SER A 25 -32.416 -12.900 -1.572 1.00 33.12 C \\\\nATOM 185 O SER A 25 -30.346 -14.912 -2.309 1.00 33.12 O \\\\nATOM 186 OG SER A 25 -31.719 -12.289 -2.643 1.00 33.12 O \\\\nATOM 187 N GLY A 26 -31.363 -16.033 -0.638 1.00 28.12 N \\\\nATOM 188 CA GLY A 26 -31.713 -17.288 -1.318 1.00 28.12 C \\\\nATOM 189 C GLY A 26 -30.714 -17.865 -2.327 1.00 28.12 C \\\\nATOM 190 O GLY A 26 -31.011 -17.915 -3.514 1.00 28.12 O \\\\nATOM 191 N GLY A 27 -29.588 -18.400 -1.852 1.00 31.96 N \\\\nATOM 192 CA GLY A 27 -28.741 -19.320 -2.619 1.00 31.96 C \\\\nATOM 193 C GLY A 27 -28.473 -20.587 -1.809 1.00 31.96 C \\\\nATOM 194 O GLY A 27 -27.802 -20.534 -0.781 1.00 31.96 O \\\\nATOM 195 N ALA A 28 -29.004 -21.729 -2.247 1.00 35.83 N \\\\nATOM 196 CA ALA A 28 -29.006 -23.014 -1.534 1.00 35.83 C \\\\nATOM 197 C ALA A 28 -27.627 -23.724 -1.429 1.00 35.83 C \\\\nATOM 198 CB ALA A 28 -30.091 -23.891 -2.180 1.00 35.83 C \\\\nATOM 199 O ALA A 28 -27.569 -24.948 -1.371 1.00 35.83 O \\\\nATOM 200 N GLY A 29 -26.513 -22.981 -1.385 1.00 39.37 N \\\\nATOM 201 CA GLY A 29 -25.144 -23.526 -1.411 1.00 39.37 C \\\\nATOM 202 C GLY A 29 -24.241 -23.187 -0.213 1.00 39.37 C \\\\nATOM 203 O GLY A 29 -23.067 -23.534 -0.238 1.00 39.37 O \\\\nATOM 204 N GLY A 30 -24.737 -22.500 0.828 1.00 39.93 N \\\\nATOM 205 CA GLY A 30 -23.887 -21.862 1.859 1.00 39.93 C \\\\nATOM 206 C GLY A 30 -23.858 -22.484 3.267 1.00 39.93 C \\\\nATOM 207 O GLY A 30 -23.334 -21.854 4.188 1.00 39.93 O \\\\nATOM 208 N GLY A 31 -24.432 -23.674 3.480 1.00 42.15 N \\\\nATOM 209 CA GLY A 31 -24.710 -24.205 4.828 1.00 42.15 C \\\\nATOM 210 C GLY A 31 -23.492 -24.328 5.759 1.00 42.15 C \\\\nATOM 211 O GLY A 31 -23.576 -23.985 6.939 1.00 42.15 O \\\\nATOM 212 N GLU A 32 -22.342 -24.764 5.242 1.00 51.18 N \\\\nATOM 213 CA GLU A 32 -21.145 -24.982 6.069 1.00 51.18 C \\\\nATOM 214 C GLU A 32 -20.403 -23.684 6.416 1.00 51.18 C \\\\nATOM 215 CB GLU A 32 -20.194 -25.962 5.376 1.00 51.18 C \\\\nATOM 216 O GLU A 32 -19.970 -23.505 7.559 1.00 51.18 O \\\\nATOM 217 CG GLU A 32 -20.775 -27.382 5.322 1.00 51.18 C \\\\nATOM 218 CD GLU A 32 -19.740 -28.389 4.808 1.00 51.18 C \\\\nATOM 219 OE1 GLU A 32 -19.671 -29.487 5.403 1.00 51.18 O \\\\nATOM 220 OE2 GLU A 32 -19.012 -28.029 3.858 1.00 51.18 O \\\\nATOM 221 N GLN A 33 -20.293 -22.752 5.461 1.00 56.72 N \\\\nATOM 222 CA GLN A 33 -19.598 -21.478 5.677 1.00 56.72 C \\\\nATOM 223 C GLN A 33 -20.337 -20.610 6.701 1.00 56.72 C \\\\nATOM 224 CB GLN A 33 -19.417 -20.721 4.353 1.00 56.72 C \\\\nATOM 225 O GLN A 33 -19.711 -20.066 7.616 1.00 56.72 O \\\\nATOM 226 CG GLN A 33 -18.447 -21.436 3.398 1.00 56.72 C \\\\nATOM 227 CD GLN A 33 -18.143 -20.615 2.147 1.00 56.72 C \\\\nATOM 228 NE2 GLN A 33 -17.830 -21.246 1.038 1.00 56.72 N \\\\nATOM 229 OE1 GLN A 33 -18.163 -19.397 2.144 1.00 56.72 O \\\\nATOM 230 N ASN A 34 -21.671 -20.572 6.618 1.00 67.29 N \\\\nATOM 231 CA ASN A 34 -22.498 -19.839 7.573 1.00 67.29 C \\\\nATOM 232 C ASN A 34 -22.352 -20.414 8.999 1.00 67.29 C \\\\nATOM 233 CB ASN A 34 -23.947 -19.854 7.053 1.00 67.29 C \\\\nATOM 234 O ASN A 34 -22.158 -19.676 9.965 1.00 67.29 O \\\\nATOM 235 CG ASN A 34 -24.826 -18.811 7.724 1.00 67.29 C \\\\nATOM 236 ND2 ASN A 34 -26.122 -18.906 7.550 1.00 67.29 N \\\\nATOM 237 OD1 ASN A 34 -24.377 -17.899 8.394 1.00 67.29 O \\\\nATOM 238 N GLY A 35 -22.302 -21.746 9.141 1.00 76.97 N \\\\nATOM 239 CA GLY A 35 -22.104 -22.400 10.439 1.00 76.97 C \\\\nATOM 240 C GLY A 35 -20.735 -22.124 11.081 1.00 76.97 C \\\\nATOM 241 O GLY A 35 -20.624 -22.025 12.309 1.00 76.97 O \\\\nATOM 242 N GLN A 36 -19.672 -21.979 10.284 1.00 80.76 N \\\\nATOM 243 CA GLN A 36 -18.354 -21.600 10.805 1.00 80.76 C \\\\nATOM 244 C GLN A 36 -18.326 -20.136 11.266 1.00 80.76 C \\\\nATOM 245 CB GLN A 36 -17.275 -21.880 9.750 1.00 80.76 C \\\\nATOM 246 O GLN A 36 -17.717 -19.827 12.298 1.00 80.76 O \\\\nATOM 247 CG GLN A 36 -15.860 -21.709 10.331 1.00 80.76 C \\\\nATOM 248 CD GLN A 36 -14.756 -22.070 9.342 1.00 80.76 C \\\\nATOM 249 NE2 GLN A 36 -13.504 -22.038 9.743 1.00 80.76 N \\\\nATOM 250 OE1 GLN A 36 -14.971 -22.380 8.191 1.00 80.76 O \\\\nATOM 251 N GLU A 37 -18.996 -19.248 10.534 1.00 83.37 N \\\\nATOM 252 CA GLU A 37 -19.110 -17.836 10.887 1.00 83.37 C \\\\nATOM 253 C GLU A 37 -19.920 -17.630 12.171 1.00 83.37 C \\\\nATOM 254 CB GLU A 37 -19.705 -17.064 9.706 1.00 83.37 C \\\\nATOM 255 O GLU A 37 -19.465 -16.931 13.078 1.00 83.37 O \\\\nATOM 256 CG GLU A 37 -19.659 -15.560 9.998 1.00 83.37 C \\\\nATOM 257 CD GLU A 37 -20.107 -14.688 8.825 1.00 83.37 C \\\\nATOM 258 OE1 GLU A 37 -20.015 -13.455 9.018 1.00 83.37 O \\\\nATOM 259 OE2 GLU A 37 -20.523 -15.243 7.790 1.00 83.37 O \\\\nATOM 260 N GLU A 38 -21.059 -18.306 12.322 1.00 85.66 N \\\\nATOM 261 CA GLU A 38 -21.865 -18.251 13.546 1.00 85.66 C \\\\nATOM 262 C GLU A 38 -21.082 -18.708 14.781 1.00 85.66 C \\\\nATOM 263 CB GLU A 38 -23.114 -19.119 13.390 1.00 85.66 C \\\\nATOM 264 O GLU A 38 -21.068 -18.015 15.806 1.00 85.66 O \\\\nATOM 265 CG GLU A 38 -24.157 -18.467 12.474 1.00 85.66 C \\\\nATOM 266 CD GLU A 38 -25.460 -19.276 12.420 1.00 85.66 C \\\\nATOM 267 OE1 GLU A 38 -26.457 -18.690 11.946 1.00 85.66 O \\\\nATOM 268 OE2 GLU A 38 -25.466 -20.426 12.919 1.00 85.66 O \\\\nATOM 269 N LYS A 39 -20.345 -19.823 14.671 1.00 86.55 N \\\\nATOM 270 CA LYS A 39 -19.451 -20.302 15.740 1.00 86.55 C \\\\nATOM 271 C LYS A 39 -18.372 -19.274 16.081 1.00 86.55 C \\\\nATOM 272 CB LYS A 39 -18.795 -21.626 15.317 1.00 86.55 C \\\\nATOM 273 O LYS A 39 -17.981 -19.150 17.245 1.00 86.55 O \\\\nATOM 274 CG LYS A 39 -19.767 -22.812 15.382 1.00 86.55 C \\\\nATOM 275 CD LYS A 39 -19.109 -24.081 14.822 1.00 86.55 C \\\\nATOM 276 CE LYS A 39 -20.135 -25.219 14.776 1.00 86.55 C \\\\nATOM 277 NZ LYS A 39 -19.592 -26.445 14.136 1.00 86.55 N \\\\nATOM 278 N TRP A 40 -17.863 -18.545 15.089 1.00 88.25 N \\\\nATOM 279 CA TRP A 40 -16.889 -17.482 15.316 1.00 88.25 C \\\\nATOM 280 C TRP A 40 -17.515 -16.281 16.041 1.00 88.25 C \\\\nATOM 281 CB TRP A 40 -16.221 -17.086 13.997 1.00 88.25 C \\\\nATOM 282 O TRP A 40 -16.951 -15.825 17.040 1.00 88.25 O \\\\nATOM 283 CG TRP A 40 -15.165 -16.048 14.177 1.00 88.25 C \\\\nATOM 284 CD1 TRP A 40 -13.860 -16.285 14.429 1.00 88.25 C \\\\nATOM 285 CD2 TRP A 40 -15.322 -14.598 14.178 1.00 88.25 C \\\\nATOM 286 CE2 TRP A 40 -14.050 -14.013 14.456 1.00 88.25 C \\\\nATOM 287 CE3 TRP A 40 -16.408 -13.723 13.961 1.00 88.25 C \\\\nATOM 288 NE1 TRP A 40 -13.204 -15.089 14.630 1.00 88.25 N \\\\nATOM 289 CH2 TRP A 40 -14.955 -11.783 14.248 1.00 88.25 C \\\\nATOM 290 CZ2 TRP A 40 -13.857 -12.626 14.495 1.00 88.25 C \\\\nATOM 291 CZ3 TRP A 40 -16.226 -12.329 13.998 1.00 88.25 C \\\\nATOM 292 N CYS A 41 -18.700 -15.828 15.616 1.00 90.26 N \\\\nATOM 293 CA CYS A 41 -19.451 -14.756 16.275 1.00 90.26 C \\\\nATOM 294 C CYS A 41 -19.745 -15.096 17.741 1.00 90.26 C \\\\nATOM 295 CB CYS A 41 -20.771 -14.510 15.529 1.00 90.26 C \\\\nATOM 296 O CYS A 41 -19.511 -14.274 18.629 1.00 90.26 O \\\\nATOM 297 SG CYS A 41 -20.480 -13.830 13.874 1.00 90.26 S \\\\nATOM 298 N GLU A 42 -20.186 -16.325 18.023 1.00 90.51 N \\\\nATOM 299 CA GLU A 42 -20.450 -16.772 19.390 1.00 90.51 C \\\\nATOM 300 C GLU A 42 -19.185 -16.721 20.259 1.00 90.51 C \\\\nATOM 301 CB GLU A 42 -21.072 -18.176 19.365 1.00 90.51 C \\\\nATOM 302 O GLU A 42 -19.226 -16.228 21.390 1.00 90.51 O \\\\nATOM 303 CG GLU A 42 -21.423 -18.629 20.789 1.00 90.51 C \\\\nATOM 304 CD GLU A 42 -22.094 -19.999 20.874 1.00 90.51 C \\\\nATOM 305 OE1 GLU A 42 -22.668 -20.264 21.960 1.00 90.51 O \\\\nATOM 306 OE2 GLU A 42 -21.847 -20.845 20.000 1.00 90.51 O \\\\nATOM 307 N LYS A 43 -18.035 -17.168 19.737 1.00 89.89 N \\\\nATOM 308 CA LYS A 43 -16.750 -17.069 20.449 1.00 89.89 C \\\\nATOM 309 C LYS A 43 -16.331 -15.615 20.685 1.00 89.89 C \\\\nATOM 310 CB LYS A 43 -15.656 -17.823 19.682 1.00 89.89 C \\\\nATOM 311 O LYS A 43 -15.843 -15.308 21.776 1.00 89.89 O \\\\nATOM 312 CG LYS A 43 -15.801 -19.351 19.770 1.00 89.89 C \\\\nATOM 313 CD LYS A 43 -14.681 -20.010 18.954 1.00 89.89 C \\\\nATOM 314 CE LYS A 43 -14.843 -21.529 18.842 1.00 89.89 C \\\\nATOM 315 NZ LYS A 43 -13.695 -22.134 18.114 1.00 89.89 N \\\\nATOM 316 N ALA A 44 -16.529 -14.728 19.707 1.00 90.90 N \\\\nATOM 317 CA ALA A 44 -16.215 -13.304 19.832 1.00 90.90 C \\\\nATOM 318 C ALA A 44 -17.040 -12.649 20.951 1.00 90.90 C \\\\nATOM 319 CB ALA A 44 -16.439 -12.611 18.479 1.00 90.90 C \\\\nATOM 320 O ALA A 44 -16.475 -12.035 21.857 1.00 90.90 O \\\\nATOM 321 N VAL A 45 -18.359 -12.866 20.957 1.00 93.13 N \\\\nATOM 322 CA VAL A 45 -19.264 -12.328 21.985 1.00 93.13 C \\\\nATOM 323 C VAL A 45 -18.977 -12.940 23.359 1.00 93.13 C \\\\nATOM 324 CB VAL A 45 -20.738 -12.517 21.575 1.00 93.13 C \\\\nATOM 325 O VAL A 45 -18.897 -12.206 24.342 1.00 93.13 O \\\\nATOM 326 CG1 VAL A 45 -21.709 -12.028 22.656 1.00 93.13 C \\\\nATOM 327 CG2 VAL A 45 -21.050 -11.716 20.305 1.00 93.13 C \\\\nATOM 328 N LYS A 46 -18.734 -14.257 23.460 1.00 90.75 N \\\\nATOM 329 CA LYS A 46 -18.327 -14.904 24.727 1.00 90.75 C \\\\nATOM 330 C LYS A 46 -17.047 -14.284 25.295 1.00 90.75 C \\\\nATOM 331 CB LYS A 46 -18.140 -16.425 24.535 1.00 90.75 C \\\\nATOM 332 O LYS A 46 -16.974 -14.020 26.497 1.00 90.75 O \\\\nATOM 333 CG LYS A 46 -19.477 -17.178 24.493 1.00 90.75 C \\\\nATOM 334 CD LYS A 46 -19.334 -18.690 24.241 1.00 90.75 C \\\\nATOM 335 CE LYS A 46 -20.738 -19.316 24.203 1.00 90.75 C \\\\nATOM 336 NZ LYS A 46 -20.772 -20.741 23.784 1.00 90.75 N \\\\nATOM 337 N SER A 47 -16.056 -14.031 24.437 1.00 89.31 N \\\\nATOM 338 CA SER A 47 -14.799 -13.380 24.817 1.00 89.31 C \\\\nATOM 339 C SER A 47 -15.031 -11.948 25.303 1.00 89.31 C \\\\nATOM 340 CB SER A 47 -13.825 -13.406 23.636 1.00 89.31 C \\\\nATOM 341 O SER A 47 -14.521 -11.576 26.363 1.00 89.31 O \\\\nATOM 342 OG SER A 47 -12.541 -12.957 24.032 1.00 89.31 O \\\\nATOM 343 N LEU A 48 -15.863 -11.169 24.599 1.00 92.11 N \\\\nATOM 344 CA LEU A 48 -16.211 -9.811 25.014 1.00 92.11 C \\\\nATOM 345 C LEU A 48 -16.908 -9.789 26.372 1.00 92.11 C \\\\nATOM 346 CB LEU A 48 -17.112 -9.131 23.972 1.00 92.11 C \\\\nATOM 347 O LEU A 48 -16.472 -9.073 27.267 1.00 92.11 O \\\\nATOM 348 CG LEU A 48 -17.369 -7.649 24.313 1.00 92.11 C \\\\nATOM 349 CD1 LEU A 48 -16.103 -6.796 24.387 1.00 92.11 C \\\\nATOM 350 CD2 LEU A 48 -18.318 -7.034 23.304 1.00 92.11 C \\\\nATOM 351 N VAL A 49 -17.948 -10.606 26.555 1.00 92.83 N \\\\nATOM 352 CA VAL A 49 -18.707 -10.674 27.811 1.00 92.83 C \\\\nATOM 353 C VAL A 49 -17.786 -11.020 28.981 1.00 92.83 C \\\\nATOM 354 CB VAL A 49 -19.863 -11.686 27.690 1.00 92.83 C \\\\nATOM 355 O VAL A 49 -17.889 -10.408 30.042 1.00 92.83 O \\\\nATOM 356 CG1 VAL A 49 -20.549 -11.969 29.034 1.00 92.83 C \\\\nATOM 357 CG2 VAL A 49 -20.943 -11.156 26.741 1.00 92.83 C \\\\nATOM 358 N LYS A 50 -16.836 -11.949 28.798 1.00 89.33 N \\\\nATOM 359 CA LYS A 50 -15.842 -12.282 29.831 1.00 89.33 C \\\\nATOM 360 C LYS A 50 -14.967 -11.079 30.205 1.00 89.33 C \\\\nATOM 361 CB LYS A 50 -14.997 -13.479 29.361 1.00 89.33 C \\\\nATOM 362 O LYS A 50 -14.634 -10.933 31.378 1.00 89.33 O \\\\nATOM 363 CG LYS A 50 -14.066 -14.014 30.465 1.00 89.33 C \\\\nATOM 364 CD LYS A 50 -13.259 -15.231 29.984 1.00 89.33 C \\\\nATOM 365 CE LYS A 50 -12.365 -15.766 31.114 1.00 89.33 C \\\\nATOM 366 NZ LYS A 50 -11.588 -16.967 30.703 1.00 89.33 N \\\\nATOM 367 N LYS A 51 -14.597 -10.230 29.238 1.00 88.71 N \\\\nATOM 368 CA LYS A 51 -13.817 -9.003 29.480 1.00 88.71 C \\\\nATOM 369 C LYS A 51 -14.659 -7.919 30.158 1.00 88.71 C \\\\nATOM 370 CB LYS A 51 -13.192 -8.490 28.171 1.00 88.71 C \\\\nATOM 371 O LYS A 51 -14.231 -7.385 31.174 1.00 88.71 O \\\\nATOM 372 CG LYS A 51 -12.089 -9.419 27.637 1.00 88.71 C \\\\nATOM 373 CD LYS A 51 -11.479 -8.842 26.352 1.00 88.71 C \\\\nATOM 374 CE LYS A 51 -10.367 -9.752 25.816 1.00 88.71 C \\\\nATOM 375 NZ LYS A 51 -9.566 -9.062 24.772 1.00 88.71 N \\\\nATOM 376 N LEU A 52 -15.874 -7.662 29.674 1.00 92.02 N \\\\nATOM 377 CA LEU A 52 -16.737 -6.597 30.202 1.00 92.02 C \\\\nATOM 378 C LEU A 52 -17.308 -6.897 31.591 1.00 92.02 C \\\\nATOM 379 CB LEU A 52 -17.871 -6.289 29.216 1.00 92.02 C \\\\nATOM 380 O LEU A 52 -17.553 -5.970 32.358 1.00 92.02 O \\\\nATOM 381 CG LEU A 52 -17.411 -5.796 27.835 1.00 92.02 C \\\\nATOM 382 CD1 LEU A 52 -18.646 -5.450 27.015 1.00 92.02 C \\\\nATOM 383 CD2 LEU A 52 -16.510 -4.565 27.878 1.00 92.02 C \\\\nATOM 384 N LYS A 53 -17.466 -8.177 31.956 1.00 90.21 N \\\\nATOM 385 CA LYS A 53 -17.799 -8.568 33.336 1.00 90.21 C \\\\nATOM 386 C LYS A 53 -16.706 -8.190 34.335 1.00 90.21 C \\\\nATOM 387 CB LYS A 53 -18.079 -10.075 33.425 1.00 90.21 C \\\\nATOM 388 O LYS A 53 -17.027 -7.907 35.480 1.00 90.21 O \\\\nATOM 389 CG LYS A 53 -19.488 -10.416 32.930 1.00 90.21 C \\\\nATOM 390 CD LYS A 53 -19.791 -11.901 33.151 1.00 90.21 C \\\\nATOM 391 CE LYS A 53 -21.242 -12.185 32.753 1.00 90.21 C \\\\nATOM 392 NZ LYS A 53 -21.682 -13.518 33.232 1.00 90.21 N \\\\nATOM 393 N LYS A 54 -15.435 -8.178 33.916 1.00 86.28 N \\\\nATOM 394 CA LYS A 54 -14.317 -7.762 34.778 1.00 86.28 C \\\\nATOM 395 C LYS A 54 -14.244 -6.244 34.944 1.00 86.28 C \\\\nATOM 396 CB LYS A 54 -12.983 -8.291 34.238 1.00 86.28 C \\\\nATOM 397 O LYS A 54 -13.834 -5.789 36.000 1.00 86.28 O \\\\nATOM 398 CG LYS A 54 -12.859 -9.818 34.308 1.00 86.28 C \\\\nATOM 399 CD LYS A 54 -11.468 -10.222 33.806 1.00 86.28 C \\\\nATOM 400 CE LYS A 54 -11.221 -11.720 33.988 1.00 86.28 C \\\\nATOM 401 NZ LYS A 54 -9.779 -12.030 33.803 1.00 86.28 N \\\\nATOM 402 N THR A 55 -14.635 -5.479 33.922 1.00 85.96 N \\\\nATOM 403 CA THR A 55 -14.583 -4.005 33.936 1.00 85.96 C \\\\nATOM 404 C THR A 55 -15.893 -3.341 34.372 1.00 85.96 C \\\\nATOM 405 CB THR A 55 -14.146 -3.452 32.568 1.00 85.96 C \\\\nATOM 406 O THR A 55 -15.940 -2.122 34.496 1.00 85.96 O \\\\nATOM 407 CG2 THR A 55 -12.763 -3.949 32.150 1.00 85.96 C \\\\nATOM 408 OG1 THR A 55 -15.038 -3.846 31.547 1.00 85.96 O \\\\nATOM 409 N GLY A 56 -16.972 -4.108 34.575 1.00 88.71 N \\\\nATOM 410 CA GLY A 56 -18.290 -3.575 34.942 1.00 88.71 C \\\\nATOM 411 C GLY A 56 -18.988 -2.791 33.821 1.00 88.71 C \\\\nATOM 412 O GLY A 56 -19.892 -2.010 34.088 1.00 88.71 O \\\\nATOM 413 N ARG A 57 -18.578 -2.970 32.557 1.00 89.65 N \\\\nATOM 414 CA ARG A 57 -19.094 -2.215 31.392 1.00 89.65 C \\\\nATOM 415 C ARG A 57 -20.141 -2.977 30.570 1.00 89.65 C \\\\nATOM 416 CB ARG A 57 -17.914 -1.754 30.516 1.00 89.65 C \\\\nATOM 417 O ARG A 57 -20.518 -2.529 29.490 1.00 89.65 O \\\\nATOM 418 CG ARG A 57 -16.913 -0.808 31.193 1.00 89.65 C \\\\nATOM 419 CD ARG A 57 -17.510 0.564 31.522 1.00 89.65 C \\\\nATOM 420 NE ARG A 57 -16.465 1.467 32.040 1.00 89.65 N \\\\nATOM 421 NH1 ARG A 57 -17.446 3.467 31.478 1.00 89.65 N \\\\nATOM 422 NH2 ARG A 57 -15.450 3.456 32.477 1.00 89.65 N \\\\nATOM 423 CZ ARG A 57 -16.463 2.787 32.001 1.00 89.65 C \\\\nATOM 424 N LEU A 58 -20.583 -4.146 31.039 1.00 92.08 N \\\\nATOM 425 CA LEU A 58 -21.513 -5.006 30.299 1.00 92.08 C \\\\nATOM 426 C LEU A 58 -22.893 -4.354 30.123 1.00 92.08 C \\\\nATOM 427 CB LEU A 58 -21.603 -6.366 31.010 1.00 92.08 C \\\\nATOM 428 O LEU A 58 -23.426 -4.374 29.017 1.00 92.08 O \\\\nATOM 429 CG LEU A 58 -22.493 -7.403 30.296 1.00 92.08 C \\\\nATOM 430 CD1 LEU A 58 -21.978 -7.747 28.893 1.00 92.08 C \\\\nATOM 431 CD2 LEU A 58 -22.483 -8.687 31.132 1.00 92.08 C \\\\nATOM 432 N ASP A 59 -23.422 -3.728 31.174 1.00 92.16 N \\\\nATOM 433 CA ASP A 59 -24.736 -3.072 31.134 1.00 92.16 C \\\\nATOM 434 C ASP A 59 -24.733 -1.855 30.197 1.00 92.16 C \\\\nATOM 435 CB ASP A 59 -25.151 -2.655 32.554 1.00 92.16 C \\\\nATOM 436 O ASP A 59 -25.700 -1.618 29.476 1.00 92.16 O \\\\nATOM 437 CG ASP A 59 -25.249 -3.839 33.523 1.00 92.16 C \\\\nATOM 438 OD1 ASP A 59 -25.561 -4.960 33.061 1.00 92.16 O \\\\nATOM 439 OD2 ASP A 59 -24.929 -3.629 34.711 1.00 92.16 O \\\\nATOM 440 N GLU A 60 -23.615 -1.123 30.132 1.00 92.46 N \\\\nATOM 441 CA GLU A 60 -23.435 -0.012 29.188 1.00 92.46 C \\\\nATOM 442 C GLU A 60 -23.424 -0.503 27.732 1.00 92.46 C \\\\nATOM 443 CB GLU A 60 -22.143 0.763 29.502 1.00 92.46 C \\\\nATOM 444 O GLU A 60 -24.003 0.152 26.867 1.00 92.46 O \\\\nATOM 445 CG GLU A 60 -22.169 1.524 30.841 1.00 92.46 C \\\\nATOM 446 CD GLU A 60 -23.135 2.728 30.898 1.00 92.46 C \\\\nATOM 447 OE1 GLU A 60 -23.315 3.275 32.013 1.00 92.46 O \\\\nATOM 448 OE2 GLU A 60 -23.622 3.188 29.838 1.00 92.46 O \\\\nATOM 449 N LEU A 61 -22.840 -1.678 27.449 1.00 93.87 N \\\\nATOM 450 CA LEU A 61 -22.908 -2.284 26.114 1.00 93.87 C \\\\nATOM 451 C LEU A 61 -24.337 -2.705 25.755 1.00 93.87 C \\\\nATOM 452 CB LEU A 61 -21.944 -3.481 26.011 1.00 93.87 C \\\\nATOM 453 O LEU A 61 -24.794 -2.415 24.650 1.00 93.87 O \\\\nATOM 454 CG LEU A 61 -21.969 -4.148 24.618 1.00 93.87 C \\\\nATOM 455 CD1 LEU A 61 -21.420 -3.231 23.519 1.00 93.87 C \\\\nATOM 456 CD2 LEU A 61 -21.150 -5.433 24.618 1.00 93.87 C \\\\nATOM 457 N GLU A 62 -25.045 -3.378 26.668 1.00 93.54 N \\\\nATOM 458 CA GLU A 62 -26.443 -3.769 26.441 1.00 93.54 C \\\\nATOM 459 C GLU A 62 -27.325 -2.540 26.204 1.00 93.54 C \\\\nATOM 460 CB GLU A 62 -26.995 -4.589 27.621 1.00 93.54 C \\\\nATOM 461 O GLU A 62 -28.126 -2.525 25.266 1.00 93.54 O \\\\nATOM 462 CG GLU A 62 -26.402 -6.004 27.667 1.00 93.54 C \\\\nATOM 463 CD GLU A 62 -27.088 -6.953 28.667 1.00 93.54 C \\\\nATOM 464 OE1 GLU A 62 -26.574 -8.083 28.830 1.00 93.54 O \\\\nATOM 465 OE2 GLU A 62 -28.202 -6.695 29.181 1.00 93.54 O \\\\nATOM 466 N LYS A 63 -27.129 -1.479 26.994 1.00 93.28 N \\\\nATOM 467 CA LYS A 63 -27.811 -0.197 26.818 1.00 93.28 C \\\\nATOM 468 C LYS A 63 -27.486 0.430 25.467 1.00 93.28 C \\\\nATOM 469 CB LYS A 63 -27.437 0.728 27.983 1.00 93.28 C \\\\nATOM 470 O LYS A 63 -28.412 0.847 24.775 1.00 93.28 O \\\\nATOM 471 CG LYS A 63 -28.233 2.040 27.961 1.00 93.28 C \\\\nATOM 472 CD LYS A 63 -27.803 2.920 29.138 1.00 93.28 C \\\\nATOM 473 CE LYS A 63 -28.577 4.240 29.125 1.00 93.28 C \\\\nATOM 474 NZ LYS A 63 -28.150 5.106 30.250 1.00 93.28 N \\\\nATOM 475 N ALA A 64 -26.217 0.479 25.066 1.00 93.52 N \\\\nATOM 476 CA ALA A 64 -25.806 1.046 23.784 1.00 93.52 C \\\\nATOM 477 C ALA A 64 -26.443 0.309 22.596 1.00 93.52 C \\\\nATOM 478 CB ALA A 64 -24.277 1.032 23.700 1.00 93.52 C \\\\nATOM 479 O ALA A 64 -27.006 0.953 21.716 1.00 93.52 O \\\\nATOM 480 N ILE A 65 -26.426 -1.029 22.605 1.00 93.03 N \\\\nATOM 481 CA ILE A 65 -27.017 -1.851 21.537 1.00 93.03 C \\\\nATOM 482 C ILE A 65 -28.545 -1.735 21.510 1.00 93.03 C \\\\nATOM 483 CB ILE A 65 -26.532 -3.315 21.639 1.00 93.03 C \\\\nATOM 484 O ILE A 65 -29.130 -1.622 20.437 1.00 93.03 O \\\\nATOM 485 CG1 ILE A 65 -25.006 -3.390 21.390 1.00 93.03 C \\\\nATOM 486 CG2 ILE A 65 -27.264 -4.212 20.620 1.00 93.03 C \\\\nATOM 487 CD1 ILE A 65 -24.401 -4.746 21.764 1.00 93.03 C \\\\nATOM 488 N THR A 66 -29.194 -1.718 22.676 1.00 92.60 N \\\\nATOM 489 CA THR A 66 -30.662 -1.653 22.763 1.00 92.60 C \\\\nATOM 490 C THR A 66 -31.198 -0.273 22.379 1.00 92.60 C \\\\nATOM 491 CB THR A 66 -31.146 -2.028 24.174 1.00 92.60 C \\\\nATOM 492 O THR A 66 -32.177 -0.171 21.647 1.00 92.60 O \\\\nATOM 493 CG2 THR A 66 -32.667 -2.135 24.269 1.00 92.60 C \\\\nATOM 494 OG1 THR A 66 -30.633 -3.284 24.551 1.00 92.60 O \\\\nATOM 495 N THR A 67 -30.559 0.797 22.863 1.00 92.64 N \\\\nATOM 496 CA THR A 67 -31.003 2.185 22.623 1.00 92.64 C \\\\nATOM 497 C THR A 67 -30.495 2.773 21.314 1.00 92.64 C \\\\nATOM 498 CB THR A 67 -30.606 3.133 23.765 1.00 92.64 C \\\\nATOM 499 O THR A 67 -31.008 3.799 20.880 1.00 92.64 O \\\\nATOM 500 CG2 THR A 67 -31.188 2.700 25.110 1.00 92.64 C \\\\nATOM 501 OG1 THR A 67 -29.206 3.215 23.915 1.00 92.64 O \\\\nATOM 502 N GLN A 68 -29.488 2.148 20.700 1.00 91.97 N \\\\nATOM 503 CA GLN A 68 -28.839 2.620 19.478 1.00 91.97 C \\\\nATOM 504 C GLN A 68 -28.338 4.071 19.573 1.00 91.97 C \\\\nATOM 505 CB GLN A 68 -29.736 2.359 18.258 1.00 91.97 C \\\\nATOM 506 O GLN A 68 -28.393 4.832 18.609 1.00 91.97 O \\\\nATOM 507 CG GLN A 68 -30.251 0.912 18.216 1.00 91.97 C \\\\nATOM 508 CD GLN A 68 -30.759 0.500 16.843 1.00 91.97 C \\\\nATOM 509 NE2 GLN A 68 -31.744 -0.367 16.782 1.00 91.97 N \\\\nATOM 510 OE1 GLN A 68 -30.267 0.904 15.800 1.00 91.97 O \\\\nATOM 511 N ASN A 69 -27.872 4.466 20.760 1.00 89.65 N \\\\nATOM 512 CA ASN A 69 -27.577 5.856 21.090 1.00 89.65 C \\\\nATOM 513 C ASN A 69 -26.068 6.099 21.251 1.00 89.65 C \\\\nATOM 514 CB ASN A 69 -28.402 6.229 22.331 1.00 89.65 C \\\\nATOM 515 O ASN A 69 -25.402 5.468 22.080 1.00 89.65 O \\\\nATOM 516 CG ASN A 69 -28.392 7.714 22.640 1.00 89.65 C \\\\nATOM 517 ND2 ASN A 69 -29.345 8.179 23.410 1.00 89.65 N \\\\nATOM 518 OD1 ASN A 69 -27.539 8.474 22.219 1.00 89.65 O \\\\nATOM 519 N CYS A 70 -25.540 7.065 20.499 1.00 90.18 N \\\\nATOM 520 CA CYS A 70 -24.140 7.490 20.554 1.00 90.18 C \\\\nATOM 521 C CYS A 70 -23.754 8.189 21.873 1.00 90.18 C \\\\nATOM 522 CB CYS A 70 -23.859 8.383 19.337 1.00 90.18 C \\\\nATOM 523 O CYS A 70 -22.586 8.165 22.245 1.00 90.18 O \\\\nATOM 524 SG CYS A 70 -24.988 9.806 19.301 1.00 90.18 S \\\\nATOM 525 N ASN A 71 -24.720 8.727 22.625 1.00 91.25 N \\\\nATOM 526 CA ASN A 71 -24.501 9.393 23.918 1.00 91.25 C \\\\nATOM 527 C ASN A 71 -24.326 8.416 25.098 1.00 91.25 C \\\\nATOM 528 CB ASN A 71 -25.653 10.379 24.174 1.00 91.25 C \\\\nATOM 529 O ASN A 71 -24.219 8.830 26.252 1.00 91.25 O \\\\nATOM 530 CG ASN A 71 -25.709 11.485 23.138 1.00 91.25 C \\\\nATOM 531 ND2 ASN A 71 -26.879 11.845 22.666 1.00 91.25 N \\\\nATOM 532 OD1 ASN A 71 -24.702 12.045 22.745 1.00 91.25 O \\\\nATOM 533 N THR A 72 -24.336 7.107 24.840 1.00 92.41 N \\\\nATOM 534 CA THR A 72 -23.986 6.097 25.850 1.00 92.41 C \\\\nATOM 535 C THR A 72 -22.507 6.193 26.239 1.00 92.41 C \\\\nATOM 536 CB THR A 72 -24.354 4.682 25.377 1.00 92.41 C \\\\nATOM 537 O THR A 72 -21.696 6.758 25.505 1.00 92.41 O \\\\nATOM 538 CG2 THR A 72 -25.874 4.478 25.331 1.00 92.41 C \\\\nATOM 539 OG1 THR A 72 -23.835 4.411 24.093 1.00 92.41 O \\\\nATOM 540 N LYS A 73 -22.125 5.663 27.410 1.00 93.98 N \\\\nATOM 541 CA LYS A 73 -20.726 5.719 27.862 1.00 93.98 C \\\\nATOM 542 C LYS A 73 -19.822 4.856 26.976 1.00 93.98 C \\\\nATOM 543 CB LYS A 73 -20.611 5.312 29.339 1.00 93.98 C \\\\nATOM 544 O LYS A 73 -20.266 3.904 26.332 1.00 93.98 O \\\\nATOM 545 CG LYS A 73 -21.291 6.319 30.278 1.00 93.98 C \\\\nATOM 546 CD LYS A 73 -21.077 5.906 31.737 1.00 93.98 C \\\\nATOM 547 CE LYS A 73 -21.893 6.794 32.679 1.00 93.98 C \\\\nATOM 548 NZ LYS A 73 -21.996 6.174 34.021 1.00 93.98 N \\\\nATOM 549 N CYS A 74 -18.523 5.163 26.980 1.00 94.08 N \\\\nATOM 550 CA CYS A 74 -17.531 4.311 26.328 1.00 94.08 C \\\\nATOM 551 C CYS A 74 -17.552 2.905 26.948 1.00 94.08 C \\\\nATOM 552 CB CYS A 74 -16.129 4.936 26.412 1.00 94.08 C \\\\nATOM 553 O CYS A 74 -17.532 2.745 28.173 1.00 94.08 O \\\\nATOM 554 SG CYS A 74 -16.008 6.429 25.382 1.00 94.08 S \\\\nATOM 555 N VAL A 75 -17.562 1.888 26.088 1.00 94.76 N \\\\nATOM 556 CA VAL A 75 -17.382 0.483 26.468 1.00 94.76 C \\\\nATOM 557 C VAL A 75 -15.969 0.112 26.067 1.00 94.76 C \\\\nATOM 558 CB VAL A 75 -18.406 -0.431 25.770 1.00 94.76 C \\\\nATOM 559 O VAL A 75 -15.702 -0.009 24.878 1.00 94.76 O \\\\nATOM 560 CG1 VAL A 75 -18.184 -1.901 26.146 1.00 94.76 C \\\\nATOM 561 CG2 VAL A 75 -19.841 -0.057 26.150 1.00 94.76 C \\\\nATOM 562 N THR A 76 -15.059 -0.032 27.023 1.00 93.46 N \\\\nATOM 563 CA THR A 76 -13.633 -0.205 26.735 1.00 93.46 C \\\\nATOM 564 C THR A 76 -13.158 -1.636 26.965 1.00 93.46 C \\\\nATOM 565 CB THR A 76 -12.778 0.807 27.509 1.00 93.46 C \\\\nATOM 566 O THR A 76 -13.692 -2.372 27.801 1.00 93.46 O \\\\nATOM 567 CG2 THR A 76 -13.114 2.240 27.106 1.00 93.46 C \\\\nATOM 568 OG1 THR A 76 -12.960 0.698 28.899 1.00 93.46 O \\\\nATOM 569 N ILE A 77 -12.156 -2.050 26.189 1.00 90.10 N \\\\nATOM 570 CA ILE A 77 -11.353 -3.243 26.468 1.00 90.10 C \\\\nATOM 571 C ILE A 77 -9.863 -2.894 26.371 1.00 90.10 C \\\\nATOM 572 CB ILE A 77 -11.712 -4.433 25.550 1.00 90.10 C \\\\nATOM 573 O ILE A 77 -9.518 -2.003 25.590 1.00 90.10 O \\\\nATOM 574 CG1 ILE A 77 -11.311 -4.212 24.075 1.00 90.10 C \\\\nATOM 575 CG2 ILE A 77 -13.194 -4.824 25.678 1.00 90.10 C \\\\nATOM 576 CD1 ILE A 77 -11.446 -5.492 23.246 1.00 90.10 C \\\\nATOM 577 N PRO A 78 -8.974 -3.630 27.063 1.00 85.17 N \\\\nATOM 578 CA PRO A 78 -7.536 -3.446 26.912 1.00 85.17 C \\\\nATOM 579 C PRO A 78 -7.113 -3.584 25.447 1.00 85.17 C \\\\nATOM 580 CB PRO A 78 -6.879 -4.504 27.802 1.00 85.17 C \\\\nATOM 581 O PRO A 78 -7.439 -4.582 24.787 1.00 85.17 O \\\\nATOM 582 CG PRO A 78 -7.942 -4.768 28.866 1.00 85.17 C \\\\nATOM 583 CD PRO A 78 -9.253 -4.611 28.100 1.00 85.17 C \\\\nATOM 584 N SER A 79 -6.401 -2.580 24.949 1.00 71.62 N \\\\nATOM 585 CA SER A 79 -5.681 -2.636 23.687 1.00 71.62 C \\\\nATOM 586 C SER A 79 -4.462 -3.539 23.896 1.00 71.62 C \\\\nATOM 587 CB SER A 79 -5.308 -1.217 23.219 1.00 71.62 C \\\\nATOM 588 O SER A 79 -3.763 -3.440 24.900 1.00 71.62 O \\\\nATOM 589 OG SER A 79 -4.110 -0.770 23.807 1.00 71.62 O \\\\nATOM 590 N THR A 80 -4.172 -4.464 22.983 1.00 59.90 N \\\\nATOM 591 CA THR A 80 -2.960 -5.301 23.097 1.00 59.90 C \\\\nATOM 592 C THR A 80 -1.685 -4.537 22.707 1.00 59.90 C \\\\nATOM 593 CB THR A 80 -3.101 -6.618 22.320 1.00 59.90 C \\\\nATOM 594 O THR A 80 -0.674 -5.158 22.406 1.00 59.90 O \\\\nATOM 595 CG2 THR A 80 -4.223 -7.497 22.877 1.00 59.90 C \\\\nATOM 596 OG1 THR A 80 -3.398 -6.369 20.967 1.00 59.90 O \\\\nATOM 597 N CYS A 81 -1.736 -3.200 22.677 1.00 47.74 N \\\\nATOM 598 CA CYS A 81 -0.661 -2.323 22.214 1.00 47.74 C \\\\nATOM 599 C CYS A 81 0.280 -1.863 23.350 1.00 47.74 C \\\\nATOM 600 CB CYS A 81 -1.319 -1.126 21.503 1.00 47.74 C \\\\nATOM 601 O CYS A 81 1.355 -1.333 23.082 1.00 47.74 O \\\\nATOM 602 SG CYS A 81 -0.392 -0.705 20.001 1.00 47.74 S \\\\nATOM 603 N SER A 82 -0.104 -2.063 24.615 1.00 37.47 N \\\\nATOM 604 CA SER A 82 0.460 -1.334 25.764 1.00 37.47 C \\\\nATOM 605 C SER A 82 1.840 -1.773 26.281 1.00 37.47 C \\\\nATOM 606 CB SER A 82 -0.560 -1.324 26.906 1.00 37.47 C \\\\nATOM 607 O SER A 82 2.295 -1.221 27.273 1.00 37.47 O \\\\nATOM 608 OG SER A 82 -1.732 -0.678 26.466 1.00 37.47 O \\\\nATOM 609 N GLU A 83 2.556 -2.707 25.645 1.00 31.77 N \\\\nATOM 610 CA GLU A 83 3.882 -3.150 26.139 1.00 31.77 C \\\\nATOM 611 C GLU A 83 5.094 -2.591 25.370 1.00 31.77 C \\\\nATOM 612 CB GLU A 83 3.915 -4.680 26.315 1.00 31.77 C \\\\nATOM 613 O GLU A 83 6.224 -2.919 25.710 1.00 31.77 O \\\\nATOM 614 CG GLU A 83 3.294 -5.082 27.666 1.00 31.77 C \\\\nATOM 615 CD GLU A 83 3.256 -6.598 27.899 1.00 31.77 C \\\\nATOM 616 OE1 GLU A 83 2.828 -7.025 29.001 1.00 31.77 O \\\\nATOM 617 OE2 GLU A 83 3.452 -7.382 26.936 1.00 31.77 O \\\\nATOM 618 N ILE A 84 4.906 -1.712 24.376 1.00 36.42 N \\\\nATOM 619 CA ILE A 84 6.024 -1.180 23.555 1.00 36.42 C \\\\nATOM 620 C ILE A 84 6.279 0.324 23.782 1.00 36.42 C \\\\nATOM 621 CB ILE A 84 5.843 -1.596 22.072 1.00 36.42 C \\\\nATOM 622 O ILE A 84 7.289 0.856 23.338 1.00 36.42 O \\\\nATOM 623 CG1 ILE A 84 5.726 -3.139 21.977 1.00 36.42 C \\\\nATOM 624 CG2 ILE A 84 6.992 -1.116 21.162 1.00 36.42 C \\\\nATOM 625 CD1 ILE A 84 5.420 -3.649 20.568 1.00 36.42 C \\\\nATOM 626 N TRP A 85 5.426 1.014 24.546 1.00 34.71 N \\\\nATOM 627 CA TRP A 85 5.549 2.464 24.793 1.00 34.71 C \\\\nATOM 628 C TRP A 85 5.761 2.828 26.271 1.00 34.71 C \\\\nATOM 629 CB TRP A 85 4.381 3.188 24.113 1.00 34.71 C \\\\nATOM 630 O TRP A 85 5.601 3.981 26.669 1.00 34.71 O \\\\nATOM 631 CG TRP A 85 4.342 2.970 22.629 1.00 34.71 C \\\\nATOM 632 CD1 TRP A 85 3.536 2.101 21.977 1.00 34.71 C \\\\nATOM 633 CD2 TRP A 85 5.203 3.561 21.607 1.00 34.71 C \\\\nATOM 634 CE2 TRP A 85 4.849 3.004 20.342 1.00 34.71 C \\\\nATOM 635 CE3 TRP A 85 6.259 4.499 21.624 1.00 34.71 C \\\\nATOM 636 NE1 TRP A 85 3.833 2.116 20.628 1.00 34.71 N \\\\nATOM 637 CH2 TRP A 85 6.542 4.307 19.203 1.00 34.71 C \\\\nATOM 638 CZ2 TRP A 85 5.500 3.365 19.152 1.00 34.71 C \\\\nATOM 639 CZ3 TRP A 85 6.920 4.870 20.436 1.00 34.71 C \\\\nATOM 640 N GLY A 86 6.149 1.843 27.086 1.00 29.44 N \\\\nATOM 641 CA GLY A 86 6.509 2.026 28.486 1.00 29.44 C \\\\nATOM 642 C GLY A 86 7.871 2.694 28.626 1.00 29.44 C \\\\nATOM 643 O GLY A 86 8.901 2.051 28.456 1.00 29.44 O \\\\nATOM 644 N LEU A 87 7.829 3.989 28.932 1.00 30.48 N \\\\nATOM 645 CA LEU A 87 8.833 4.761 29.663 1.00 30.48 C \\\\nATOM 646 C LEU A 87 9.878 3.875 30.357 1.00 30.48 C \\\\nATOM 647 CB LEU A 87 8.064 5.590 30.711 1.00 30.48 C \\\\nATOM 648 O LEU A 87 9.633 3.302 31.418 1.00 30.48 O \\\\nATOM 649 CG LEU A 87 7.241 6.738 30.097 1.00 30.48 C \\\\nATOM 650 CD1 LEU A 87 6.038 7.073 30.977 1.00 30.48 C \\\\nATOM 651 CD2 LEU A 87 8.101 7.992 29.942 1.00 30.48 C \\\\nATOM 652 N SER A 88 11.063 3.814 29.760 1.00 25.22 N \\\\nATOM 653 CA SER A 88 12.293 3.451 30.440 1.00 25.22 C \\\\nATOM 654 C SER A 88 12.496 4.428 31.599 1.00 25.22 C \\\\nATOM 655 CB SER A 88 13.476 3.470 29.450 1.00 25.22 C \\\\nATOM 656 O SER A 88 12.966 5.549 31.422 1.00 25.22 O \\\\nATOM 657 OG SER A 88 13.191 4.184 28.252 1.00 25.22 O \\\\nATOM 658 N THR A 89 12.136 4.009 32.810 1.00 30.16 N \\\\nATOM 659 CA THR A 89 12.752 4.561 34.014 1.00 30.16 C \\\\nATOM 660 C THR A 89 14.230 4.167 33.984 1.00 30.16 C \\\\nATOM 661 CB THR A 89 12.091 4.035 35.295 1.00 30.16 C \\\\nATOM 662 O THR A 89 14.527 2.970 33.921 1.00 30.16 O \\\\nATOM 663 CG2 THR A 89 10.757 4.732 35.552 1.00 30.16 C \\\\nATOM 664 OG1 THR A 89 11.841 2.651 35.201 1.00 30.16 O \\\\nATOM 665 N PRO A 90 15.173 5.124 34.002 1.00 28.90 N \\\\nATOM 666 CA PRO A 90 16.584 4.803 34.088 1.00 28.90 C \\\\nATOM 667 C PRO A 90 16.835 4.377 35.529 1.00 28.90 C \\\\nATOM 668 CB PRO A 90 17.313 6.095 33.707 1.00 28.90 C \\\\nATOM 669 O PRO A 90 16.705 5.202 36.424 1.00 28.90 O \\\\nATOM 670 CG PRO A 90 16.362 7.203 34.168 1.00 28.90 C \\\\nATOM 671 CD PRO A 90 14.973 6.563 34.105 1.00 28.90 C \\\\nATOM 672 N ASN A 91 17.056 3.084 35.752 1.00 29.36 N \\\\nATOM 673 CA ASN A 91 17.805 2.494 36.867 1.00 29.36 C \\\\nATOM 674 C ASN A 91 17.425 1.019 36.949 1.00 29.36 C \\\\nATOM 675 CB ASN A 91 17.552 3.179 38.232 1.00 29.36 C \\\\nATOM 676 O ASN A 91 16.373 0.683 37.484 1.00 29.36 O \\\\nATOM 677 CG ASN A 91 18.396 4.431 38.428 1.00 29.36 C \\\\nATOM 678 ND2 ASN A 91 18.022 5.292 39.346 1.00 29.36 N \\\\nATOM 679 OD1 ASN A 91 19.401 4.654 37.771 1.00 29.36 O \\\\nATOM 680 N THR A 92 18.254 0.164 36.353 1.00 32.37 N \\\\nATOM 681 CA THR A 92 18.830 -1.072 36.920 1.00 32.37 C \\\\nATOM 682 C THR A 92 19.379 -1.865 35.730 1.00 32.37 C \\\\nATOM 683 CB THR A 92 17.909 -1.961 37.789 1.00 32.37 C \\\\nATOM 684 O THR A 92 18.694 -2.679 35.117 1.00 32.37 O \\\\nATOM 685 CG2 THR A 92 18.737 -3.005 38.536 1.00 32.37 C \\\\nATOM 686 OG1 THR A 92 17.303 -1.246 38.836 1.00 32.37 O \\\\nATOM 687 N ILE A 93 20.615 -1.541 35.349 1.00 28.03 N \\\\nATOM 688 CA ILE A 93 21.522 -2.503 34.722 1.00 28.03 C \\\\nATOM 689 C ILE A 93 21.924 -3.445 35.857 1.00 28.03 C \\\\nATOM 690 CB ILE A 93 22.731 -1.736 34.106 1.00 28.03 C \\\\nATOM 691 O ILE A 93 22.379 -2.948 36.879 1.00 28.03 O \\\\nATOM 692 CG1 ILE A 93 22.439 -1.434 32.620 1.00 28.03 C \\\\nATOM 693 CG2 ILE A 93 24.089 -2.445 34.256 1.00 28.03 C \\\\nATOM 694 CD1 ILE A 93 23.420 -0.446 31.969 1.00 28.03 C \\\\nATOM 695 N ASP A 94 21.669 -4.747 35.726 1.00 28.87 N \\\\nATOM 696 CA ASP A 94 22.699 -5.776 35.917 1.00 28.87 C \\\\nATOM 697 C ASP A 94 22.152 -7.210 35.825 1.00 28.87 C \\\\nATOM 698 CB ASP A 94 23.527 -5.601 37.216 1.00 28.87 C \\\\nATOM 699 O ASP A 94 21.021 -7.503 36.202 1.00 28.87 O \\\\nATOM 700 CG ASP A 94 24.797 -4.765 36.982 1.00 28.87 C \\\\nATOM 701 OD1 ASP A 94 25.372 -4.904 35.874 1.00 28.87 O \\\\nATOM 702 OD2 ASP A 94 25.229 -4.050 37.912 1.00 28.87 O \\\\nATOM 703 N GLN A 95 23.048 -8.084 35.356 1.00 28.34 N \\\\nATOM 704 CA GLN A 95 23.051 -9.550 35.431 1.00 28.34 C \\\\nATOM 705 C GLN A 95 22.244 -10.349 34.398 1.00 28.34 C \\\\nATOM 706 CB GLN A 95 22.909 -10.039 36.878 1.00 28.34 C \\\\nATOM 707 O GLN A 95 21.122 -10.808 34.592 1.00 28.34 O \\\\nATOM 708 CG GLN A 95 24.224 -9.778 37.628 1.00 28.34 C \\\\nATOM 709 CD GLN A 95 24.151 -10.082 39.115 1.00 28.34 C \\\\nATOM 710 NE2 GLN A 95 25.259 -9.974 39.813 1.00 28.34 N \\\\nATOM 711 OE1 GLN A 95 23.125 -10.391 39.695 1.00 28.34 O \\\\nATOM 712 N TRP A 96 22.942 -10.621 33.298 1.00 28.28 N \\\\nATOM 713 CA TRP A 96 22.775 -11.798 32.453 1.00 28.28 C \\\\nATOM 714 C TRP A 96 23.284 -13.016 33.228 1.00 28.28 C \\\\nATOM 715 CB TRP A 96 23.558 -11.586 31.132 1.00 28.28 C \\\\nATOM 716 O TRP A 96 24.493 -13.222 33.312 1.00 28.28 O \\\\nATOM 717 CG TRP A 96 24.418 -10.350 31.070 1.00 28.28 C \\\\nATOM 718 CD1 TRP A 96 23.944 -9.116 30.787 1.00 28.28 C \\\\nATOM 719 CD2 TRP A 96 25.832 -10.165 31.407 1.00 28.28 C \\\\nATOM 720 CE2 TRP A 96 26.137 -8.773 31.296 1.00 28.28 C \\\\nATOM 721 CE3 TRP A 96 26.882 -11.012 31.826 1.00 28.28 C \\\\nATOM 722 NE1 TRP A 96 24.950 -8.184 30.923 1.00 28.28 N \\\\nATOM 723 CH2 TRP A 96 28.435 -9.124 31.956 1.00 28.28 C \\\\nATOM 724 CZ2 TRP A 96 27.409 -8.249 31.563 1.00 28.28 C \\\\nATOM 725 CZ3 TRP A 96 28.169 -10.499 32.089 1.00 28.28 C \\\\nATOM 726 N ASP A 97 22.372 -13.816 33.783 1.00 30.80 N \\\\nATOM 727 CA ASP A 97 22.724 -15.109 34.364 1.00 30.80 C \\\\nATOM 728 C ASP A 97 22.295 -16.277 33.477 1.00 30.80 C \\\\nATOM 729 CB ASP A 97 22.293 -15.250 35.836 1.00 30.80 C \\\\nATOM 730 O ASP A 97 21.179 -16.376 32.964 1.00 30.80 O \\\\nATOM 731 CG ASP A 97 23.484 -15.319 36.808 1.00 30.80 C \\\\nATOM 732 OD1 ASP A 97 24.590 -15.712 36.366 1.00 30.80 O \\\\nATOM 733 OD2 ASP A 97 23.262 -15.039 38.003 1.00 30.80 O \\\\nATOM 734 N THR A 98 23.271 -17.153 33.269 1.00 31.38 N \\\\nATOM 735 CA THR A 98 23.314 -18.206 32.260 1.00 31.38 C \\\\nATOM 736 C THR A 98 22.985 -19.534 32.926 1.00 31.38 C \\\\nATOM 737 CB THR A 98 24.722 -18.229 31.618 1.00 31.38 C \\\\nATOM 738 O THR A 98 23.879 -20.339 33.113 1.00 31.38 O \\\\nATOM 739 CG2 THR A 98 24.846 -19.152 30.402 1.00 31.38 C \\\\nATOM 740 OG1 THR A 98 25.071 -16.945 31.158 1.00 31.38 O \\\\nATOM 741 N THR A 99 21.741 -19.796 33.338 1.00 33.23 N \\\\nATOM 742 CA THR A 99 21.313 -21.157 33.728 1.00 33.23 C \\\\nATOM 743 C THR A 99 19.787 -21.311 33.746 1.00 33.23 C \\\\nATOM 744 CB THR A 99 21.846 -21.623 35.107 1.00 33.23 C \\\\nATOM 745 O THR A 99 19.082 -20.562 34.402 1.00 33.23 O \\\\nATOM 746 CG2 THR A 99 23.257 -22.219 35.127 1.00 33.23 C \\\\nATOM 747 OG1 THR A 99 21.824 -20.599 36.064 1.00 33.23 O \\\\nATOM 748 N GLY A 100 19.296 -22.335 33.041 1.00 27.30 N \\\\nATOM 749 CA GLY A 100 18.237 -23.241 33.502 1.00 27.30 C \\\\nATOM 750 C GLY A 100 16.857 -22.696 33.906 1.00 27.30 C \\\\nATOM 751 O GLY A 100 16.671 -22.157 34.986 1.00 27.30 O \\\\nATOM 752 N LEU A 101 15.853 -23.125 33.132 1.00 27.46 N \\\\nATOM 753 CA LEU A 101 14.538 -23.565 33.627 1.00 27.46 C \\\\nATOM 754 C LEU A 101 13.613 -22.492 34.228 1.00 27.46 C \\\\nATOM 755 CB LEU A 101 14.733 -24.746 34.612 1.00 27.46 C \\\\nATOM 756 O LEU A 101 13.380 -22.483 35.428 1.00 27.46 O \\\\nATOM 757 CG LEU A 101 15.334 -26.022 34.005 1.00 27.46 C \\\\nATOM 758 CD1 LEU A 101 15.954 -26.888 35.100 1.00 27.46 C \\\\nATOM 759 CD2 LEU A 101 14.255 -26.838 33.290 1.00 27.46 C \\\\nATOM 760 N TYR A 102 12.916 -21.736 33.373 1.00 30.22 N \\\\nATOM 761 CA TYR A 102 11.531 -21.351 33.669 1.00 30.22 C \\\\nATOM 762 C TYR A 102 10.646 -21.485 32.430 1.00 30.22 C \\\\nATOM 763 CB TYR A 102 11.414 -19.976 34.345 1.00 30.22 C \\\\nATOM 764 O TYR A 102 10.863 -20.877 31.385 1.00 30.22 O \\\\nATOM 765 CG TYR A 102 11.474 -20.073 35.861 1.00 30.22 C \\\\nATOM 766 CD1 TYR A 102 10.316 -20.404 36.597 1.00 30.22 C \\\\nATOM 767 CD2 TYR A 102 12.702 -19.909 36.528 1.00 30.22 C \\\\nATOM 768 CE1 TYR A 102 10.395 -20.584 37.993 1.00 30.22 C \\\\nATOM 769 CE2 TYR A 102 12.789 -20.106 37.919 1.00 30.22 C \\\\nATOM 770 OH TYR A 102 11.715 -20.639 39.995 1.00 30.22 O \\\\nATOM 771 CZ TYR A 102 11.635 -20.446 38.653 1.00 30.22 C \\\\nATOM 772 N SER A 103 9.636 -22.332 32.579 1.00 24.84 N \\\\nATOM 773 CA SER A 103 8.519 -22.529 31.672 1.00 24.84 C \\\\nATOM 774 C SER A 103 7.653 -21.269 31.646 1.00 24.84 C \\\\nATOM 775 CB SER A 103 7.727 -23.752 32.167 1.00 24.84 C \\\\nATOM 776 O SER A 103 6.948 -20.964 32.604 1.00 24.84 O \\\\nATOM 777 OG SER A 103 7.608 -23.765 33.584 1.00 24.84 O \\\\nATOM 778 N PHE A 104 7.684 -20.532 30.536 1.00 27.44 N \\\\nATOM 779 CA PHE A 104 6.739 -19.449 30.283 1.00 27.44 C \\\\nATOM 780 C PHE A 104 5.822 -19.864 29.138 1.00 27.44 C \\\\nATOM 781 CB PHE A 104 7.459 -18.110 30.061 1.00 27.44 C \\\\nATOM 782 O PHE A 104 6.258 -20.127 28.023 1.00 27.44 O \\\\nATOM 783 CG PHE A 104 6.856 -16.986 30.884 1.00 27.44 C \\\\nATOM 784 CD1 PHE A 104 5.896 -16.119 30.327 1.00 27.44 C \\\\nATOM 785 CD2 PHE A 104 7.246 -16.822 32.227 1.00 27.44 C \\\\nATOM 786 CE1 PHE A 104 5.346 -15.083 31.105 1.00 27.44 C \\\\nATOM 787 CE2 PHE A 104 6.696 -15.788 33.004 1.00 27.44 C \\\\nATOM 788 CZ PHE A 104 5.749 -14.915 32.443 1.00 27.44 C \\\\nATOM 789 N SER A 105 4.533 -19.978 29.442 1.00 27.30 N \\\\nATOM 790 CA SER A 105 3.481 -20.297 28.485 1.00 27.30 C \\\\nATOM 791 C SER A 105 3.463 -19.278 27.338 1.00 27.30 C \\\\nATOM 792 CB SER A 105 2.141 -20.303 29.231 1.00 27.30 C \\\\nATOM 793 O SER A 105 3.019 -18.142 27.521 1.00 27.30 O \\\\nATOM 794 OG SER A 105 1.982 -19.098 29.958 1.00 27.30 O \\\\nATOM 795 N GLU A 106 3.917 -19.692 26.156 1.00 25.42 N \\\\nATOM 796 CA GLU A 106 3.860 -18.921 24.914 1.00 25.42 C \\\\nATOM 797 C GLU A 106 2.403 -18.745 24.448 1.00 25.42 C \\\\nATOM 798 CB GLU A 106 4.702 -19.607 23.823 1.00 25.42 C \\\\nATOM 799 O GLU A 106 1.842 -19.550 23.706 1.00 25.42 O \\\\nATOM 800 CG GLU A 106 6.214 -19.418 24.009 1.00 25.42 C \\\\nATOM 801 CD GLU A 106 7.009 -20.112 22.892 1.00 25.42 C \\\\nATOM 802 OE1 GLU A 106 7.955 -19.480 22.375 1.00 25.42 O \\\\nATOM 803 OE2 GLU A 106 6.631 -21.253 22.542 1.00 25.42 O \\\\nATOM 804 N GLN A 107 1.765 -17.653 24.872 1.00 28.28 N \\\\nATOM 805 CA GLN A 107 0.642 -17.059 24.146 1.00 28.28 C \\\\nATOM 806 C GLN A 107 1.187 -15.917 23.290 1.00 28.28 C \\\\nATOM 807 CB GLN A 107 -0.488 -16.621 25.098 1.00 28.28 C \\\\nATOM 808 O GLN A 107 1.437 -14.817 23.774 1.00 28.28 O \\\\nATOM 809 CG GLN A 107 -1.620 -17.657 25.091 1.00 28.28 C \\\\nATOM 810 CD GLN A 107 -2.763 -17.340 26.051 1.00 28.28 C \\\\nATOM 811 NE2 GLN A 107 -3.799 -18.150 26.062 1.00 28.28 N \\\\nATOM 812 OE1 GLN A 107 -2.782 -16.380 26.803 1.00 28.28 O \\\\nATOM 813 N THR A 108 1.370 -16.198 22.003 1.00 28.45 N \\\\nATOM 814 CA THR A 108 1.763 -15.256 20.948 1.00 28.45 C \\\\nATOM 815 C THR A 108 0.865 -14.004 20.952 1.00 28.45 C \\\\nATOM 816 CB THR A 108 1.719 -15.973 19.575 1.00 28.45 C \\\\nATOM 817 O THR A 108 -0.259 -14.024 20.446 1.00 28.45 O \\\\nATOM 818 CG2 THR A 108 3.096 -16.467 19.142 1.00 28.45 C \\\\nATOM 819 OG1 THR A 108 0.905 -17.134 19.580 1.00 28.45 O \\\\nATOM 820 N ARG A 109 1.351 -12.899 21.542 1.00 34.15 N \\\\nATOM 821 CA ARG A 109 0.684 -11.581 21.578 1.00 34.15 C \\\\nATOM 822 C ARG A 109 0.880 -10.832 20.252 1.00 34.15 C \\\\nATOM 823 CB ARG A 109 1.190 -10.740 22.773 1.00 34.15 C \\\\nATOM 824 O ARG A 109 1.962 -10.830 19.675 1.00 34.15 O \\\\nATOM 825 CG ARG A 109 0.662 -11.219 24.138 1.00 34.15 C \\\\nATOM 826 CD ARG A 109 1.170 -10.320 25.277 1.00 34.15 C \\\\nATOM 827 NE ARG A 109 0.667 -10.750 26.600 1.00 34.15 N \\\\nATOM 828 NH1 ARG A 109 1.439 -8.933 27.757 1.00 34.15 N \\\\nATOM 829 NH2 ARG A 109 0.374 -10.503 28.864 1.00 34.15 N \\\\nATOM 830 CZ ARG A 109 0.826 -10.067 27.724 1.00 34.15 C \\\\nATOM 831 N SER A 110 -0.182 -10.209 19.747 1.00 40.36 N \\\\nATOM 832 CA SER A 110 -0.188 -9.347 18.556 1.00 40.36 C \\\\nATOM 833 C SER A 110 0.285 -7.932 18.902 1.00 40.36 C \\\\nATOM 834 CB SER A 110 -1.599 -9.285 17.940 1.00 40.36 C \\\\nATOM 835 O SER A 110 -0.391 -7.226 19.647 1.00 40.36 O \\\\nATOM 836 OG SER A 110 -2.593 -9.587 18.901 1.00 40.36 O \\\\nATOM 837 N LEU A 111 1.410 -7.521 18.308 1.00 46.85 N \\\\nATOM 838 CA LEU A 111 2.098 -6.232 18.510 1.00 46.85 C \\\\nATOM 839 C LEU A 111 1.354 -5.012 17.914 1.00 46.85 C \\\\nATOM 840 CB LEU A 111 3.521 -6.342 17.906 1.00 46.85 C \\\\nATOM 841 O LEU A 111 1.835 -3.891 18.007 1.00 46.85 O \\\\nATOM 842 CG LEU A 111 4.412 -7.471 18.467 1.00 46.85 C \\\\nATOM 843 CD1 LEU A 111 5.636 -7.678 17.575 1.00 46.85 C \\\\nATOM 844 CD2 LEU A 111 4.914 -7.198 19.881 1.00 46.85 C \\\\nATOM 845 N ASP A 112 0.196 -5.213 17.281 1.00 55.73 N \\\\nATOM 846 CA ASP A 112 -0.514 -4.217 16.466 1.00 55.73 C \\\\nATOM 847 C ASP A 112 -1.930 -3.883 16.980 1.00 55.73 C \\\\nATOM 848 CB ASP A 112 -0.510 -4.692 15.001 1.00 55.73 C \\\\nATOM 849 O ASP A 112 -2.784 -3.407 16.231 1.00 55.73 O \\\\nATOM 850 CG ASP A 112 -1.314 -5.975 14.740 1.00 55.73 C \\\\nATOM 851 OD1 ASP A 112 -1.678 -6.702 15.700 1.00 55.73 O \\\\nATOM 852 OD2 ASP A 112 -1.580 -6.257 13.548 1.00 55.73 O \\\\nATOM 853 N GLY A 113 -2.224 -4.171 18.253 1.00 59.81 N \\\\nATOM 854 CA GLY A 113 -3.535 -3.895 18.857 1.00 59.81 C \\\\nATOM 855 C GLY A 113 -4.675 -4.818 18.389 1.00 59.81 C \\\\nATOM 856 O GLY A 113 -5.836 -4.599 18.750 1.00 59.81 O \\\\nATOM 857 N ARG A 114 -4.391 -5.854 17.582 1.00 63.47 N \\\\nATOM 858 CA ARG A 114 -5.409 -6.800 17.093 1.00 63.47 C \\\\nATOM 859 C ARG A 114 -5.798 -7.824 18.152 1.00 63.47 C \\\\nATOM 860 CB ARG A 114 -4.942 -7.495 15.809 1.00 63.47 C \\\\nATOM 861 O ARG A 114 -4.953 -8.455 18.775 1.00 63.47 O \\\\nATOM 862 CG ARG A 114 -4.841 -6.507 14.643 1.00 63.47 C \\\\nATOM 863 CD ARG A 114 -4.440 -7.238 13.362 1.00 63.47 C \\\\nATOM 864 NE ARG A 114 -4.171 -6.273 12.286 1.00 63.47 N \\\\nATOM 865 NH1 ARG A 114 -3.462 -7.784 10.712 1.00 63.47 N \\\\nATOM 866 NH2 ARG A 114 -3.261 -5.593 10.321 1.00 63.47 N \\\\nATOM 867 CZ ARG A 114 -3.634 -6.555 11.116 1.00 63.47 C \\\\nATOM 868 N LEU A 115 -7.096 -8.079 18.277 1.00 74.63 N \\\\nATOM 869 CA LEU A 115 -7.659 -9.174 19.058 1.00 74.63 C \\\\nATOM 870 C LEU A 115 -7.690 -10.461 18.228 1.00 74.63 C \\\\nATOM 871 CB LEU A 115 -9.063 -8.754 19.520 1.00 74.63 C \\\\nATOM 872 O LEU A 115 -8.206 -10.474 17.111 1.00 74.63 O \\\\nATOM 873 CG LEU A 115 -9.828 -9.795 20.351 1.00 74.63 C \\\\nATOM 874 CD1 LEU A 115 -9.130 -10.049 21.690 1.00 74.63 C \\\\nATOM 875 CD2 LEU A 115 -11.243 -9.286 20.637 1.00 74.63 C \\\\nATOM 876 N GLN A 116 -7.198 -11.560 18.799 1.00 75.91 N \\\\nATOM 877 CA GLN A 116 -7.332 -12.890 18.211 1.00 75.91 C \\\\nATOM 878 C GLN A 116 -8.573 -13.606 18.758 1.00 75.91 C \\\\nATOM 879 CB GLN A 116 -6.034 -13.680 18.419 1.00 75.91 C \\\\nATOM 880 O GLN A 116 -8.695 -13.840 19.961 1.00 75.91 O \\\\nATOM 881 CG GLN A 116 -6.031 -15.028 17.672 1.00 75.91 C \\\\nATOM 882 CD GLN A 116 -4.640 -15.661 17.623 1.00 75.91 C \\\\nATOM 883 NE2 GLN A 116 -4.521 -16.957 17.437 1.00 75.91 N \\\\nATOM 884 OE1 GLN A 116 -3.625 -14.996 17.701 1.00 75.91 O \\\\nATOM 885 N VAL A 117 -9.483 -13.994 17.865 1.00 72.04 N \\\\nATOM 886 CA VAL A 117 -10.655 -14.827 18.167 1.00 72.04 C \\\\nATOM 887 C VAL A 117 -10.622 -16.049 17.256 1.00 72.04 C \\\\nATOM 888 CB VAL A 117 -11.978 -14.051 17.996 1.00 72.04 C \\\\nATOM 889 O VAL A 117 -10.773 -15.928 16.043 1.00 72.04 O \\\\nATOM 890 CG1 VAL A 117 -13.165 -14.936 18.402 1.00 72.04 C \\\\nATOM 891 CG2 VAL A 117 -12.019 -12.777 18.849 1.00 72.04 C \\\\nATOM 892 N SER A 118 -10.434 -17.240 17.837 1.00 68.99 N \\\\nATOM 893 CA SER A 118 -10.448 -18.525 17.114 1.00 68.99 C \\\\nATOM 894 C SER A 118 -9.568 -18.523 15.851 1.00 68.99 C \\\\nATOM 895 CB SER A 118 -11.902 -18.925 16.820 1.00 68.99 C \\\\nATOM 896 O SER A 118 -10.045 -18.857 14.771 1.00 68.99 O \\\\nATOM 897 OG SER A 118 -12.005 -20.289 16.448 1.00 68.99 O \\\\nATOM 898 N HIS A 119 -8.298 -18.123 15.997 1.00 68.93 N \\\\nATOM 899 CA HIS A 119 -7.280 -17.992 14.933 1.00 68.93 C \\\\nATOM 900 C HIS A 119 -7.458 -16.828 13.945 1.00 68.93 C \\\\nATOM 901 CB HIS A 119 -7.038 -19.332 14.213 1.00 68.93 C \\\\nATOM 902 O HIS A 119 -6.550 -16.568 13.163 1.00 68.93 O \\\\nATOM 903 CG HIS A 119 -6.783 -20.471 15.161 1.00 68.93 C \\\\nATOM 904 CD2 HIS A 119 -7.722 -21.318 15.683 1.00 68.93 C \\\\nATOM 905 ND1 HIS A 119 -5.566 -20.833 15.692 1.00 68.93 N \\\\nATOM 906 CE1 HIS A 119 -5.772 -21.870 16.522 1.00 68.93 C \\\\nATOM 907 NE2 HIS A 119 -7.079 -22.174 16.576 1.00 68.93 N \\\\nATOM 908 N ARG A 120 -8.551 -16.058 14.018 1.00 73.52 N \\\\nATOM 909 CA ARG A 120 -8.704 -14.816 13.243 1.00 73.52 C \\\\nATOM 910 C ARG A 120 -8.238 -13.621 14.072 1.00 73.52 C \\\\nATOM 911 CB ARG A 120 -10.150 -14.654 12.750 1.00 73.52 C \\\\nATOM 912 O ARG A 120 -8.711 -13.441 15.194 1.00 73.52 O \\\\nATOM 913 CG ARG A 120 -10.598 -15.814 11.841 1.00 73.52 C \\\\nATOM 914 CD ARG A 120 -11.986 -15.551 11.237 1.00 73.52 C \\\\nATOM 915 NE ARG A 120 -12.393 -16.616 10.296 1.00 73.52 N \\\\nATOM 916 NH1 ARG A 120 -14.515 -15.835 9.841 1.00 73.52 N \\\\nATOM 917 NH2 ARG A 120 -13.766 -17.643 8.785 1.00 73.52 N \\\\nATOM 918 CZ ARG A 120 -13.550 -16.692 9.650 1.00 73.52 C \\\\nATOM 919 N LYS A 121 -7.316 -12.819 13.535 1.00 76.82 N \\\\nATOM 920 CA LYS A 121 -6.859 -11.555 14.138 1.00 76.82 C \\\\nATOM 921 C LYS A 121 -7.628 -10.391 13.514 1.00 76.82 C \\\\nATOM 922 CB LYS A 121 -5.338 -11.376 13.963 1.00 76.82 C \\\\nATOM 923 O LYS A 121 -7.679 -10.288 12.295 1.00 76.82 O \\\\nATOM 924 CG LYS A 121 -4.515 -12.378 14.792 1.00 76.82 C \\\\nATOM 925 CD LYS A 121 -3.003 -12.124 14.659 1.00 76.82 C \\\\nATOM 926 CE LYS A 121 -2.218 -13.100 15.552 1.00 76.82 C \\\\nATOM 927 NZ LYS A 121 -0.748 -12.887 15.486 1.00 76.82 N \\\\nATOM 928 N GLY A 122 -8.187 -9.507 14.332 1.00 81.47 N \\\\nATOM 929 CA GLY A 122 -8.886 -8.310 13.863 1.00 81.47 C \\\\nATOM 930 C GLY A 122 -8.894 -7.214 14.919 1.00 81.47 C \\\\nATOM 931 O GLY A 122 -8.692 -7.476 16.103 1.00 81.47 O \\\\nATOM 932 N LEU A 123 -9.103 -5.968 14.505 1.00 87.81 N \\\\nATOM 933 CA LEU A 123 -9.176 -4.849 15.442 1.00 87.81 C \\\\nATOM 934 C LEU A 123 -10.486 -4.927 16.247 1.00 87.81 C \\\\nATOM 935 CB LEU A 123 -9.035 -3.529 14.676 1.00 87.81 C \\\\nATOM 936 O LEU A 123 -11.540 -5.149 15.648 1.00 87.81 O \\\\nATOM 937 CG LEU A 123 -7.629 -3.315 14.083 1.00 87.81 C \\\\nATOM 938 CD1 LEU A 123 -7.642 -2.128 13.128 1.00 87.81 C \\\\nATOM 939 CD2 LEU A 123 -6.585 -3.067 15.172 1.00 87.81 C \\\\nATOM 940 N PRO A 124 -10.460 -4.748 17.583 1.00 91.18 N \\\\nATOM 941 CA PRO A 124 -11.645 -4.955 18.413 1.00 91.18 C \\\\nATOM 942 C PRO A 124 -12.867 -4.149 17.976 1.00 91.18 C \\\\nATOM 943 CB PRO A 124 -11.227 -4.558 19.825 1.00 91.18 C \\\\nATOM 944 O PRO A 124 -13.944 -4.708 17.804 1.00 91.18 O \\\\nATOM 945 CG PRO A 124 -9.724 -4.812 19.848 1.00 91.18 C \\\\nATOM 946 CD PRO A 124 -9.285 -4.515 18.417 1.00 91.18 C \\\\nATOM 947 N HIS A 125 -12.693 -2.846 17.760 1.00 92.35 N \\\\nATOM 948 CA HIS A 125 -13.778 -1.954 17.364 1.00 92.35 C \\\\nATOM 949 C HIS A 125 -14.386 -2.352 16.009 1.00 92.35 C \\\\nATOM 950 CB HIS A 125 -13.265 -0.512 17.371 1.00 92.35 C \\\\nATOM 951 O HIS A 125 -15.605 -2.341 15.875 1.00 92.35 O \\\\nATOM 952 CG HIS A 125 -12.171 -0.245 16.372 1.00 92.35 C \\\\nATOM 953 CD2 HIS A 125 -12.325 0.383 15.167 1.00 92.35 C \\\\nATOM 954 ND1 HIS A 125 -10.841 -0.590 16.492 1.00 92.35 N \\\\nATOM 955 CE1 HIS A 125 -10.216 -0.192 15.373 1.00 92.35 C \\\\nATOM 956 NE2 HIS A 125 -11.081 0.391 14.540 1.00 92.35 N \\\\nATOM 957 N VAL A 126 -13.568 -2.806 15.049 1.00 92.28 N \\\\nATOM 958 CA VAL A 126 -14.039 -3.320 13.750 1.00 92.28 C \\\\nATOM 959 C VAL A 126 -14.865 -4.590 13.928 1.00 92.28 C \\\\nATOM 960 CB VAL A 126 -12.871 -3.598 12.784 1.00 92.28 C \\\\nATOM 961 O VAL A 126 -15.959 -4.678 13.385 1.00 92.28 O \\\\nATOM 962 CG1 VAL A 126 -13.341 -4.074 11.404 1.00 92.28 C \\\\nATOM 963 CG2 VAL A 126 -12.036 -2.341 12.566 1.00 92.28 C \\\\nATOM 964 N ILE A 127 -14.385 -5.556 14.724 1.00 92.20 N \\\\nATOM 965 CA ILE A 127 -15.093 -6.826 14.975 1.00 92.20 C \\\\nATOM 966 C ILE A 127 -16.507 -6.566 15.506 1.00 92.20 C \\\\nATOM 967 CB ILE A 127 -14.283 -7.710 15.959 1.00 92.20 C \\\\nATOM 968 O ILE A 127 -17.475 -7.159 15.032 1.00 92.20 O \\\\nATOM 969 CG1 ILE A 127 -13.002 -8.244 15.276 1.00 92.20 C \\\\nATOM 970 CG2 ILE A 127 -15.144 -8.865 16.517 1.00 92.20 C \\\\nATOM 971 CD1 ILE A 127 -11.991 -8.869 16.249 1.00 92.20 C \\\\nATOM 972 N TYR A 128 -16.629 -5.678 16.490 1.00 94.45 N \\\\nATOM 973 CA TYR A 128 -17.897 -5.428 17.169 1.00 94.45 C \\\\nATOM 974 C TYR A 128 -18.826 -4.489 16.387 1.00 94.45 C \\\\nATOM 975 CB TYR A 128 -17.579 -4.936 18.580 1.00 94.45 C \\\\nATOM 976 O TYR A 128 -20.036 -4.712 16.376 1.00 94.45 O \\\\nATOM 977 CG TYR A 128 -16.888 -5.987 19.446 1.00 94.45 C \\\\nATOM 978 CD1 TYR A 128 -17.417 -7.286 19.612 1.00 94.45 C \\\\nATOM 979 CD2 TYR A 128 -15.647 -5.676 20.023 1.00 94.45 C \\\\nATOM 980 CE1 TYR A 128 -16.688 -8.263 20.326 1.00 94.45 C \\\\nATOM 981 CE2 TYR A 128 -14.923 -6.631 20.751 1.00 94.45 C \\\\nATOM 982 OH TYR A 128 -14.702 -8.853 21.570 1.00 94.45 O \\\\nATOM 983 CZ TYR A 128 -15.439 -7.932 20.894 1.00 94.45 C \\\\nATOM 984 N CYS A 129 -18.287 -3.513 15.647 1.00 94.84 N \\\\nATOM 985 CA CYS A 129 -19.075 -2.754 14.671 1.00 94.84 C \\\\nATOM 986 C CYS A 129 -19.608 -3.661 13.555 1.00 94.84 C \\\\nATOM 987 CB CYS A 129 -18.240 -1.615 14.078 1.00 94.84 C \\\\nATOM 988 O CYS A 129 -20.777 -3.539 13.185 1.00 94.84 O \\\\nATOM 989 SG CYS A 129 -17.923 -0.349 15.334 1.00 94.84 S \\\\nATOM 990 N ARG A 130 -18.794 -4.612 13.071 1.00 93.45 N \\\\nATOM 991 CA ARG A 130 -19.218 -5.591 12.064 1.00 93.45 C \\\\nATOM 992 C ARG A 130 -20.382 -6.446 12.561 1.00 93.45 C \\\\nATOM 993 CB ARG A 130 -18.024 -6.446 11.593 1.00 93.45 C \\\\nATOM 994 O ARG A 130 -21.346 -6.669 11.841 1.00 93.45 O \\\\nATOM 995 CG ARG A 130 -18.402 -7.345 10.401 1.00 93.45 C \\\\nATOM 996 CD ARG A 130 -17.297 -8.325 9.987 1.00 93.45 C \\\\nATOM 997 NE ARG A 130 -16.140 -7.643 9.388 1.00 93.45 N \\\\nATOM 998 NH1 ARG A 130 -14.894 -9.481 8.823 1.00 93.45 N \\\\nATOM 999 NH2 ARG A 130 -14.164 -7.456 8.280 1.00 93.45 N \\\\nATOM 1000 CZ ARG A 130 -15.073 -8.194 8.841 1.00 93.45 C \\\\nATOM 1001 N LEU A 131 -20.314 -6.886 13.817 1.00 93.42 N \\\\nATOM 1002 CA LEU A 131 -21.314 -7.774 14.406 1.00 93.42 C \\\\nATOM 1003 C LEU A 131 -22.680 -7.088 14.596 1.00 93.42 C \\\\nATOM 1004 CB LEU A 131 -20.719 -8.351 15.707 1.00 93.42 C \\\\nATOM 1005 O LEU A 131 -23.709 -7.687 14.289 1.00 93.42 O \\\\nATOM 1006 CG LEU A 131 -21.370 -9.671 16.157 1.00 93.42 C \\\\nATOM 1007 CD1 LEU A 131 -20.361 -10.540 16.910 1.00 93.42 C \\\\nATOM 1008 CD2 LEU A 131 -22.557 -9.466 17.093 1.00 93.42 C \\\\nATOM 1009 N TRP A 132 -22.702 -5.844 15.089 1.00 95.06 N \\\\nATOM 1010 CA TRP A 132 -23.948 -5.172 15.499 1.00 95.06 C \\\\nATOM 1011 C TRP A 132 -24.456 -4.081 14.555 1.00 95.06 C \\\\nATOM 1012 CB TRP A 132 -23.787 -4.636 16.926 1.00 95.06 C \\\\nATOM 1013 O TRP A 132 -25.597 -3.646 14.709 1.00 95.06 O \\\\nATOM 1014 CG TRP A 132 -23.688 -5.707 17.963 1.00 95.06 C \\\\nATOM 1015 CD1 TRP A 132 -24.630 -6.650 18.186 1.00 95.06 C \\\\nATOM 1016 CD2 TRP A 132 -22.612 -5.982 18.908 1.00 95.06 C \\\\nATOM 1017 CE2 TRP A 132 -22.962 -7.158 19.640 1.00 95.06 C \\\\nATOM 1018 CE3 TRP A 132 -21.388 -5.357 19.239 1.00 95.06 C \\\\nATOM 1019 NE1 TRP A 132 -24.209 -7.512 19.174 1.00 95.06 N \\\\nATOM 1020 CH2 TRP A 132 -20.887 -7.109 20.860 1.00 95.06 C \\\\nATOM 1021 CZ2 TRP A 132 -22.104 -7.738 20.579 1.00 95.06 C \\\\nATOM 1022 CZ3 TRP A 132 -20.553 -5.900 20.234 1.00 95.06 C \\\\nATOM 1023 N ARG A 133 -23.656 -3.624 13.585 1.00 93.80 N \\\\nATOM 1024 CA ARG A 133 -24.057 -2.527 12.688 1.00 93.80 C \\\\nATOM 1025 C ARG A 133 -23.903 -2.858 11.214 1.00 93.80 C \\\\nATOM 1026 CB ARG A 133 -23.327 -1.232 13.054 1.00 93.80 C \\\\nATOM 1027 O ARG A 133 -24.900 -2.799 10.502 1.00 93.80 O \\\\nATOM 1028 CG ARG A 133 -23.740 -0.768 14.456 1.00 93.80 C \\\\nATOM 1029 CD ARG A 133 -23.208 0.630 14.740 1.00 93.80 C \\\\nATOM 1030 NE ARG A 133 -23.885 1.638 13.906 1.00 93.80 N \\\\nATOM 1031 NH1 ARG A 133 -22.534 3.330 14.523 1.00 93.80 N \\\\nATOM 1032 NH2 ARG A 133 -24.172 3.753 13.078 1.00 93.80 N \\\\nATOM 1033 CZ ARG A 133 -23.534 2.902 13.829 1.00 93.80 C \\\\nATOM 1034 N TRP A 134 -22.698 -3.219 10.781 1.00 92.86 N \\\\nATOM 1035 CA TRP A 134 -22.355 -3.332 9.359 1.00 92.86 C \\\\nATOM 1036 C TRP A 134 -21.638 -4.658 9.065 1.00 92.86 C \\\\nATOM 1037 CB TRP A 134 -21.502 -2.122 8.961 1.00 92.86 C \\\\nATOM 1038 O TRP A 134 -20.412 -4.713 9.159 1.00 92.86 O \\\\nATOM 1039 CG TRP A 134 -22.128 -0.786 9.203 1.00 92.86 C \\\\nATOM 1040 CD1 TRP A 134 -23.200 -0.283 8.552 1.00 92.86 C \\\\nATOM 1041 CD2 TRP A 134 -21.717 0.237 10.155 1.00 92.86 C \\\\nATOM 1042 CE2 TRP A 134 -22.578 1.364 10.001 1.00 92.86 C \\\\nATOM 1043 CE3 TRP A 134 -20.693 0.326 11.122 1.00 92.86 C \\\\nATOM 1044 NE1 TRP A 134 -23.466 0.992 9.014 1.00 92.86 N \\\\nATOM 1045 CH2 TRP A 134 -21.345 2.608 11.666 1.00 92.86 C \\\\nATOM 1046 CZ2 TRP A 134 -22.397 2.543 10.734 1.00 92.86 C \\\\nATOM 1047 CZ3 TRP A 134 -20.518 1.495 11.882 1.00 92.86 C \\\\nATOM 1048 N PRO A 135 -22.366 -5.742 8.736 1.00 90.70 N \\\\nATOM 1049 CA PRO A 135 -21.776 -7.058 8.453 1.00 90.70 C \\\\nATOM 1050 C PRO A 135 -20.717 -7.044 7.344 1.00 90.70 C \\\\nATOM 1051 CB PRO A 135 -22.955 -7.949 8.049 1.00 90.70 C \\\\nATOM 1052 O PRO A 135 -19.789 -7.847 7.363 1.00 90.70 O \\\\nATOM 1053 CG PRO A 135 -24.131 -7.309 8.777 1.00 90.70 C \\\\nATOM 1054 CD PRO A 135 -23.817 -5.820 8.695 1.00 90.70 C \\\\nATOM 1055 N ASP A 136 -20.846 -6.097 6.421 1.00 86.88 N \\\\nATOM 1056 CA ASP A 136 -19.995 -5.838 5.263 1.00 86.88 C \\\\nATOM 1057 C ASP A 136 -18.812 -4.895 5.560 1.00 86.88 C \\\\nATOM 1058 CB ASP A 136 -20.896 -5.265 4.158 1.00 86.88 C \\\\nATOM 1059 O ASP A 136 -18.151 -4.428 4.642 1.00 86.88 O \\\\nATOM 1060 CG ASP A 136 -21.458 -3.882 4.516 1.00 86.88 C \\\\nATOM 1061 OD1 ASP A 136 -21.929 -3.679 5.663 1.00 86.88 O \\\\nATOM 1062 OD2 ASP A 136 -21.416 -2.979 3.656 1.00 86.88 O \\\\nATOM 1063 N LEU A 137 -18.537 -4.569 6.825 1.00 87.97 N \\\\nATOM 1064 CA LEU A 137 -17.401 -3.726 7.204 1.00 87.97 C \\\\nATOM 1065 C LEU A 137 -16.083 -4.498 7.075 1.00 87.97 C \\\\nATOM 1066 CB LEU A 137 -17.626 -3.275 8.656 1.00 87.97 C \\\\nATOM 1067 O LEU A 137 -15.883 -5.449 7.826 1.00 87.97 O \\\\nATOM 1068 CG LEU A 137 -16.543 -2.322 9.169 1.00 87.97 C \\\\nATOM 1069 CD1 LEU A 137 -16.738 -0.932 8.577 1.00 87.97 C \\\\nATOM 1070 CD2 LEU A 137 -16.615 -2.224 10.690 1.00 87.97 C \\\\nATOM 1071 N HIS A 138 -15.128 -4.080 6.248 1.00 80.97 N \\\\nATOM 1072 CA HIS A 138 -13.871 -4.808 6.009 1.00 80.97 C \\\\nATOM 1073 C HIS A 138 -12.685 -4.237 6.790 1.00 80.97 C \\\\nATOM 1074 CB HIS A 138 -13.578 -4.858 4.507 1.00 80.97 C \\\\nATOM 1075 O HIS A 138 -11.864 -4.998 7.313 1.00 80.97 O \\\\nATOM 1076 CG HIS A 138 -14.632 -5.637 3.769 1.00 80.97 C \\\\nATOM 1077 CD2 HIS A 138 -14.644 -6.985 3.527 1.00 80.97 C \\\\nATOM 1078 ND1 HIS A 138 -15.826 -5.137 3.311 1.00 80.97 N \\\\nATOM 1079 CE1 HIS A 138 -16.550 -6.158 2.830 1.00 80.97 C \\\\nATOM 1080 NE2 HIS A 138 -15.882 -7.311 2.973 1.00 80.97 N \\\\nATOM 1081 N SER A 139 -12.614 -2.912 6.917 1.00 83.17 N \\\\nATOM 1082 CA SER A 139 -11.460 -2.200 7.465 1.00 83.17 C \\\\nATOM 1083 C SER A 139 -11.837 -1.201 8.559 1.00 83.17 C \\\\nATOM 1084 CB SER A 139 -10.727 -1.495 6.323 1.00 83.17 C \\\\nATOM 1085 O SER A 139 -12.946 -0.681 8.615 1.00 83.17 O \\\\nATOM 1086 OG SER A 139 -9.516 -0.929 6.795 1.00 83.17 O \\\\nATOM 1087 N HIS A 140 -10.874 -0.881 9.425 1.00 86.11 N \\\\nATOM 1088 CA HIS A 140 -11.016 0.216 10.386 1.00 86.11 C \\\\nATOM 1089 C HIS A 140 -11.071 1.593 9.723 1.00 86.11 C \\\\nATOM 1090 CB HIS A 140 -9.873 0.183 11.399 1.00 86.11 C \\\\nATOM 1091 O HIS A 140 -11.634 2.512 10.302 1.00 86.11 O \\\\nATOM 1092 CG HIS A 140 -8.528 0.596 10.861 1.00 86.11 C \\\\nATOM 1093 CD2 HIS A 140 -7.865 1.738 11.215 1.00 86.11 C \\\\nATOM 1094 ND1 HIS A 140 -7.736 -0.065 9.944 1.00 86.11 N \\\\nATOM 1095 CE1 HIS A 140 -6.614 0.656 9.776 1.00 86.11 C \\\\nATOM 1096 NE2 HIS A 140 -6.642 1.752 10.548 1.00 86.11 N \\\\nATOM 1097 N HIS A 141 -10.518 1.731 8.516 1.00 83.95 N \\\\nATOM 1098 CA HIS A 141 -10.558 2.982 7.763 1.00 83.95 C \\\\nATOM 1099 C HIS A 141 -11.983 3.357 7.319 1.00 83.95 C \\\\nATOM 1100 CB HIS A 141 -9.626 2.852 6.557 1.00 83.95 C \\\\nATOM 1101 O HIS A 141 -12.252 4.526 7.079 1.00 83.95 O \\\\nATOM 1102 CG HIS A 141 -8.176 2.638 6.875 1.00 83.95 C \\\\nATOM 1103 CD2 HIS A 141 -7.388 1.619 6.415 1.00 83.95 C \\\\nATOM 1104 ND1 HIS A 141 -7.370 3.480 7.600 1.00 83.95 N \\\\nATOM 1105 CE1 HIS A 141 -6.130 2.966 7.596 1.00 83.95 C \\\\nATOM 1106 NE2 HIS A 141 -6.101 1.811 6.913 1.00 83.95 N \\\\nATOM 1107 N GLU A 142 -12.907 2.391 7.256 1.00 89.04 N \\\\nATOM 1108 CA GLU A 142 -14.330 2.634 6.979 1.00 89.04 C \\\\nATOM 1109 C GLU A 142 -15.081 3.182 8.203 1.00 89.04 C \\\\nATOM 1110 CB GLU A 142 -14.996 1.327 6.533 1.00 89.04 C \\\\nATOM 1111 O GLU A 142 -16.275 3.461 8.114 1.00 89.04 O \\\\nATOM 1112 CG GLU A 142 -14.534 0.776 5.184 1.00 89.04 C \\\\nATOM 1113 CD GLU A 142 -15.197 -0.587 4.961 1.00 89.04 C \\\\nATOM 1114 OE1 GLU A 142 -14.500 -1.600 5.214 1.00 89.04 O \\\\nATOM 1115 OE2 GLU A 142 -16.417 -0.627 4.667 1.00 89.04 O \\\\nATOM 1116 N LEU A 143 -14.414 3.318 9.354 1.00 92.20 N \\\\nATOM 1117 CA LEU A 143 -14.996 3.828 10.589 1.00 92.20 C \\\\nATOM 1118 C LEU A 143 -14.329 5.133 11.019 1.00 92.20 C \\\\nATOM 1119 CB LEU A 143 -14.878 2.787 11.713 1.00 92.20 C \\\\nATOM 1120 O LEU A 143 -13.109 5.228 11.135 1.00 92.20 O \\\\nATOM 1121 CG LEU A 143 -15.634 1.470 11.494 1.00 92.20 C \\\\nATOM 1122 CD1 LEU A 143 -15.407 0.591 12.728 1.00 92.20 C \\\\nATOM 1123 CD2 LEU A 143 -17.138 1.678 11.311 1.00 92.20 C \\\\nATOM 1124 N LYS A 144 -15.152 6.111 11.389 1.00 92.19 N \\\\nATOM 1125 CA LYS A 144 -14.738 7.329 12.086 1.00 92.19 C \\\\nATOM 1126 C LYS A 144 -15.326 7.324 13.491 1.00 92.19 C \\\\nATOM 1127 CB LYS A 144 -15.184 8.540 11.257 1.00 92.19 C \\\\nATOM 1128 O LYS A 144 -16.518 7.089 13.653 1.00 92.19 O \\\\nATOM 1129 CG LYS A 144 -14.603 9.851 11.803 1.00 92.19 C \\\\nATOM 1130 CD LYS A 144 -15.084 11.048 10.975 1.00 92.19 C \\\\nATOM 1131 CE LYS A 144 -14.518 12.350 11.557 1.00 92.19 C \\\\nATOM 1132 NZ LYS A 144 -15.052 13.546 10.857 1.00 92.19 N \\\\nATOM 1133 N ALA A 145 -14.516 7.560 14.518 1.00 93.48 N \\\\nATOM 1134 CA ALA A 145 -15.049 7.713 15.868 1.00 93.48 C \\\\nATOM 1135 C ALA A 145 -15.831 9.030 16.001 1.00 93.48 C \\\\nATOM 1136 CB ALA A 145 -13.917 7.608 16.883 1.00 93.48 C \\\\nATOM 1137 O ALA A 145 -15.466 10.033 15.386 1.00 93.48 O \\\\nATOM 1138 N ILE A 146 -16.892 9.026 16.808 1.00 93.88 N \\\\nATOM 1139 CA ILE A 146 -17.597 10.257 17.182 1.00 93.88 C \\\\nATOM 1140 C ILE A 146 -16.704 11.122 18.078 1.00 93.88 C \\\\nATOM 1141 CB ILE A 146 -18.961 9.968 17.849 1.00 93.88 C \\\\nATOM 1142 O ILE A 146 -15.877 10.599 18.826 1.00 93.88 O \\\\nATOM 1143 CG1 ILE A 146 -18.805 9.282 19.226 1.00 93.88 C \\\\nATOM 1144 CG2 ILE A 146 -19.859 9.172 16.883 1.00 93.88 C \\\\nATOM 1145 CD1 ILE A 146 -20.121 9.053 19.971 1.00 93.88 C \\\\nATOM 1146 N GLU A 147 -16.913 12.435 18.052 1.00 91.33 N \\\\nATOM 1147 CA GLU A 147 -16.085 13.403 18.790 1.00 91.33 C \\\\nATOM 1148 C GLU A 147 -16.111 13.177 20.310 1.00 91.33 C \\\\nATOM 1149 CB GLU A 147 -16.553 14.823 18.439 1.00 91.33 C \\\\nATOM 1150 O GLU A 147 -15.098 13.340 20.983 1.00 91.33 O \\\\nATOM 1151 CG GLU A 147 -16.354 15.112 16.940 1.00 91.33 C \\\\nATOM 1152 CD GLU A 147 -16.770 16.525 16.513 1.00 91.33 C \\\\nATOM 1153 OE1 GLU A 147 -16.509 16.831 15.328 1.00 91.33 O \\\\nATOM 1154 OE2 GLU A 147 -17.365 17.248 17.340 1.00 91.33 O \\\\nATOM 1155 N ASN A 148 -17.234 12.684 20.840 1.00 91.34 N \\\\nATOM 1156 CA ASN A 148 -17.417 12.424 22.271 1.00 91.34 C \\\\nATOM 1157 C ASN A 148 -16.788 11.098 22.750 1.00 91.34 C \\\\nATOM 1158 CB ASN A 148 -18.923 12.499 22.595 1.00 91.34 C \\\\nATOM 1159 O ASN A 148 -16.949 10.719 23.912 1.00 91.34 O \\\\nATOM 1160 CG ASN A 148 -19.535 13.868 22.344 1.00 91.34 C \\\\nATOM 1161 ND2 ASN A 148 -20.838 13.988 22.425 1.00 91.34 N \\\\nATOM 1162 OD1 ASN A 148 -18.871 14.846 22.065 1.00 91.34 O \\\\nATOM 1163 N CYS A 149 -16.116 10.339 21.876 1.00 93.59 N \\\\nATOM 1164 CA CYS A 149 -15.512 9.064 22.252 1.00 93.59 C \\\\nATOM 1165 C CYS A 149 -14.118 9.261 22.868 1.00 93.59 C \\\\nATOM 1166 CB CYS A 149 -15.482 8.123 21.045 1.00 93.59 C \\\\nATOM 1167 O CYS A 149 -13.117 9.411 22.171 1.00 93.59 O \\\\nATOM 1168 SG CYS A 149 -15.018 6.462 21.626 1.00 93.59 S \\\\nATOM 1169 N GLU A 150 -14.029 9.163 24.194 1.00 93.72 N \\\\nATOM 1170 CA GLU A 150 -12.774 9.344 24.940 1.00 93.72 C \\\\nATOM 1171 C GLU A 150 -11.730 8.236 24.711 1.00 93.72 C \\\\nATOM 1172 CB GLU A 150 -13.086 9.387 26.438 1.00 93.72 C \\\\nATOM 1173 O GLU A 150 -10.553 8.426 25.023 1.00 93.72 O \\\\nATOM 1174 CG GLU A 150 -13.967 10.569 26.859 1.00 93.72 C \\\\nATOM 1175 CD GLU A 150 -14.248 10.552 28.369 1.00 93.72 C \\\\nATOM 1176 OE1 GLU A 150 -14.711 11.592 28.878 1.00 93.72 O \\\\nATOM 1177 OE2 GLU A 150 -14.031 9.488 29.003 1.00 93.72 O \\\\nATOM 1178 N TYR A 151 -12.142 7.075 24.195 1.00 93.47 N \\\\nATOM 1179 CA TYR A 151 -11.293 5.890 23.995 1.00 93.47 C \\\\nATOM 1180 C TYR A 151 -11.321 5.414 22.538 1.00 93.47 C \\\\nATOM 1181 CB TYR A 151 -11.669 4.785 24.992 1.00 93.47 C \\\\nATOM 1182 O TYR A 151 -11.233 4.219 22.254 1.00 93.47 O \\\\nATOM 1183 CG TYR A 151 -11.472 5.166 26.442 1.00 93.47 C \\\\nATOM 1184 CD1 TYR A 151 -10.273 4.836 27.103 1.00 93.47 C \\\\nATOM 1185 CD2 TYR A 151 -12.494 5.844 27.131 1.00 93.47 C \\\\nATOM 1186 CE1 TYR A 151 -10.105 5.180 28.459 1.00 93.47 C \\\\nATOM 1187 CE2 TYR A 151 -12.315 6.225 28.472 1.00 93.47 C \\\\nATOM 1188 OH TYR A 151 -10.938 6.273 30.427 1.00 93.47 O \\\\nATOM 1189 CZ TYR A 151 -11.120 5.884 29.140 1.00 93.47 C \\\\nATOM 1190 N ALA A 152 -11.501 6.342 21.600 1.00 91.45 N \\\\nATOM 1191 CA ALA A 152 -11.484 6.039 20.179 1.00 91.45 C \\\\nATOM 1192 C ALA A 152 -10.160 5.383 19.747 1.00 91.45 C \\\\nATOM 1193 CB ALA A 152 -11.749 7.336 19.422 1.00 91.45 C \\\\nATOM 1194 O ALA A 152 -9.087 5.708 20.256 1.00 91.45 O \\\\nATOM 1195 N PHE A 153 -10.225 4.463 18.780 1.00 88.26 N \\\\nATOM 1196 CA PHE A 153 -9.057 3.704 18.316 1.00 88.26 C \\\\nATOM 1197 C PHE A 153 -7.881 4.587 17.858 1.00 88.26 C \\\\nATOM 1198 CB PHE A 153 -9.508 2.782 17.176 1.00 88.26 C \\\\nATOM 1199 O PHE A 153 -6.724 4.286 18.149 1.00 88.26 O \\\\nATOM 1200 CG PHE A 153 -8.366 2.037 16.511 1.00 88.26 C \\\\nATOM 1201 CD1 PHE A 153 -7.961 2.377 15.205 1.00 88.26 C \\\\nATOM 1202 CD2 PHE A 153 -7.685 1.024 17.212 1.00 88.26 C \\\\nATOM 1203 CE1 PHE A 153 -6.883 1.703 14.605 1.00 88.26 C \\\\nATOM 1204 CE2 PHE A 153 -6.613 0.347 16.607 1.00 88.26 C \\\\nATOM 1205 CZ PHE A 153 -6.213 0.684 15.303 1.00 88.26 C \\\\nATOM 1206 N ASN A 154 -8.167 5.704 17.189 1.00 84.98 N \\\\nATOM 1207 CA ASN A 154 -7.164 6.657 16.710 1.00 84.98 C \\\\nATOM 1208 C ASN A 154 -6.425 7.402 17.838 1.00 84.98 C \\\\nATOM 1209 CB ASN A 154 -7.825 7.648 15.730 1.00 84.98 C \\\\nATOM 1210 O ASN A 154 -5.341 7.921 17.585 1.00 84.98 O \\\\nATOM 1211 CG ASN A 154 -8.927 8.482 16.366 1.00 84.98 C \\\\nATOM 1212 ND2 ASN A 154 -9.030 9.748 16.048 1.00 84.98 N \\\\nATOM 1213 OD1 ASN A 154 -9.725 7.990 17.145 1.00 84.98 O \\\\nATOM 1214 N LEU A 155 -6.959 7.425 19.067 1.00 87.90 N \\\\nATOM 1215 CA LEU A 155 -6.299 8.036 20.228 1.00 87.90 C \\\\nATOM 1216 C LEU A 155 -5.151 7.181 20.790 1.00 87.90 C \\\\nATOM 1217 CB LEU A 155 -7.331 8.347 21.331 1.00 87.90 C \\\\nATOM 1218 O LEU A 155 -4.417 7.667 21.644 1.00 87.90 O \\\\nATOM 1219 CG LEU A 155 -8.442 9.332 20.931 1.00 87.90 C \\\\nATOM 1220 CD1 LEU A 155 -9.445 9.459 22.078 1.00 87.90 C \\\\nATOM 1221 CD2 LEU A 155 -7.894 10.724 20.616 1.00 87.90 C \\\\nATOM 1222 N LYS A 156 -4.992 5.926 20.330 1.00 83.25 N \\\\nATOM 1223 CA LYS A 156 -3.895 5.009 20.710 1.00 83.25 C \\\\nATOM 1224 C LYS A 156 -3.679 4.876 22.230 1.00 83.25 C \\\\nATOM 1225 CB LYS A 156 -2.595 5.394 19.979 1.00 83.25 C \\\\nATOM 1226 O LYS A 156 -2.548 4.755 22.690 1.00 83.25 O \\\\nATOM 1227 CG LYS A 156 -2.698 5.336 18.450 1.00 83.25 C \\\\nATOM 1228 CD LYS A 156 -1.342 5.712 17.841 1.00 83.25 C \\\\nATOM 1229 CE LYS A 156 -1.398 5.654 16.312 1.00 83.25 C \\\\nATOM 1230 NZ LYS A 156 -0.087 6.019 15.718 1.00 83.25 N \\\\nATOM 1231 N LYS A 157 -4.767 4.903 23.003 1.00 86.70 N \\\\nATOM 1232 CA LYS A 157 -4.747 4.689 24.457 1.00 86.70 C \\\\nATOM 1233 C LYS A 157 -4.578 3.207 24.801 1.00 86.70 C \\\\nATOM 1234 CB LYS A 157 -6.028 5.266 25.084 1.00 86.70 C \\\\nATOM 1235 O LYS A 157 -4.794 2.338 23.958 1.00 86.70 O \\\\nATOM 1236 CG LYS A 157 -6.087 6.797 24.984 1.00 86.70 C \\\\nATOM 1237 CD LYS A 157 -7.306 7.338 25.742 1.00 86.70 C \\\\nATOM 1238 CE LYS A 157 -7.300 8.869 25.738 1.00 86.70 C \\\\nATOM 1239 NZ LYS A 157 -8.459 9.409 26.489 1.00 86.70 N \\\\nATOM 1240 N ASP A 158 -4.286 2.931 26.072 1.00 86.03 N \\\\nATOM 1241 CA ASP A 158 -4.174 1.565 26.599 1.00 86.03 C \\\\nATOM 1242 C ASP A 158 -5.472 0.765 26.502 1.00 86.03 C \\\\nATOM 1243 CB ASP A 158 -3.732 1.605 28.067 1.00 86.03 C \\\\nATOM 1244 O ASP A 158 -5.446 -0.463 26.437 1.00 86.03 O \\\\nATOM 1245 CG ASP A 158 -2.309 2.127 28.218 1.00 86.03 C \\\\nATOM 1246 OD1 ASP A 158 -1.483 1.767 27.348 1.00 86.03 O \\\\nATOM 1247 OD2 ASP A 158 -2.084 2.884 29.182 1.00 86.03 O \\\\nATOM 1248 N GLU A 159 -6.611 1.447 26.423 1.00 90.02 N \\\\nATOM 1249 CA GLU A 159 -7.905 0.844 26.152 1.00 90.02 C \\\\nATOM 1250 C GLU A 159 -8.516 1.379 24.857 1.00 90.02 C \\\\nATOM 1251 CB GLU A 159 -8.876 1.060 27.310 1.00 90.02 C \\\\nATOM 1252 O GLU A 159 -8.314 2.531 24.473 1.00 90.02 O \\\\nATOM 1253 CG GLU A 159 -8.393 0.591 28.687 1.00 90.02 C \\\\nATOM 1254 CD GLU A 159 -9.585 0.508 29.654 1.00 90.02 C \\\\nATOM 1255 OE1 GLU A 159 -9.783 -0.580 30.240 1.00 90.02 O \\\\nATOM 1256 OE2 GLU A 159 -10.397 1.463 29.700 1.00 90.02 O \\\\nATOM 1257 N VAL A 160 -9.326 0.542 24.209 1.00 92.39 N \\\\nATOM 1258 CA VAL A 160 -10.071 0.894 22.997 1.00 92.39 C \\\\nATOM 1259 C VAL A 160 -11.570 0.743 23.224 1.00 92.39 C \\\\nATOM 1260 CB VAL A 160 -9.555 0.097 21.785 1.00 92.39 C \\\\nATOM 1261 O VAL A 160 -12.034 -0.267 23.762 1.00 92.39 O \\\\nATOM 1262 CG1 VAL A 160 -9.741 -1.423 21.908 1.00 92.39 C \\\\nATOM 1263 CG2 VAL A 160 -10.216 0.560 20.481 1.00 92.39 C \\\\nATOM 1264 N CYS A 161 -12.340 1.738 22.786 1.00 95.50 N \\\\nATOM 1265 CA CYS A 161 -13.791 1.693 22.797 1.00 95.50 C \\\\nATOM 1266 C CYS A 161 -14.298 0.686 21.760 1.00 95.50 C \\\\nATOM 1267 CB CYS A 161 -14.386 3.086 22.558 1.00 95.50 C \\\\nATOM 1268 O CYS A 161 -13.922 0.727 20.589 1.00 95.50 O \\\\nATOM 1269 SG CYS A 161 -16.167 3.003 22.908 1.00 95.50 S \\\\nATOM 1270 N VAL A 162 -15.186 -0.203 22.184 1.00 94.95 N \\\\nATOM 1271 CA VAL A 162 -15.862 -1.212 21.362 1.00 94.95 C \\\\nATOM 1272 C VAL A 162 -17.372 -0.992 21.289 1.00 94.95 C \\\\nATOM 1273 CB VAL A 162 -15.524 -2.631 21.842 1.00 94.95 C \\\\nATOM 1274 O VAL A 162 -18.089 -1.851 20.781 1.00 94.95 O \\\\nATOM 1275 CG1 VAL A 162 -14.031 -2.924 21.651 1.00 94.95 C \\\\nATOM 1276 CG2 VAL A 162 -15.898 -2.904 23.300 1.00 94.95 C \\\\nATOM 1277 N ASN A 163 -17.863 0.148 21.786 1.00 95.41 N \\\\nATOM 1278 CA ASN A 163 -19.251 0.553 21.605 1.00 95.41 C \\\\nATOM 1279 C ASN A 163 -19.493 0.835 20.110 1.00 95.41 C \\\\nATOM 1280 CB ASN A 163 -19.545 1.782 22.483 1.00 95.41 C \\\\nATOM 1281 O ASN A 163 -18.922 1.790 19.579 1.00 95.41 O \\\\nATOM 1282 CG ASN A 163 -20.991 2.243 22.403 1.00 95.41 C \\\\nATOM 1283 ND2 ASN A 163 -21.418 3.024 23.364 1.00 95.41 N \\\\nATOM 1284 OD1 ASN A 163 -21.735 1.892 21.496 1.00 95.41 O \\\\nATOM 1285 N PRO A 164 -20.333 0.052 19.411 1.00 94.93 N \\\\nATOM 1286 CA PRO A 164 -20.509 0.213 17.974 1.00 94.93 C \\\\nATOM 1287 C PRO A 164 -21.177 1.545 17.590 1.00 94.93 C \\\\nATOM 1288 CB PRO A 164 -21.316 -1.015 17.552 1.00 94.93 C \\\\nATOM 1289 O PRO A 164 -21.033 1.986 16.452 1.00 94.93 O \\\\nATOM 1290 CG PRO A 164 -22.135 -1.362 18.793 1.00 94.93 C \\\\nATOM 1291 CD PRO A 164 -21.163 -1.033 19.920 1.00 94.93 C \\\\nATOM 1292 N TYR A 165 -21.868 2.218 18.518 1.00 95.74 N \\\\nATOM 1293 CA TYR A 165 -22.497 3.531 18.306 1.00 95.74 C \\\\nATOM 1294 C TYR A 165 -21.555 4.711 18.578 1.00 95.74 C \\\\nATOM 1295 CB TYR A 165 -23.792 3.622 19.123 1.00 95.74 C \\\\nATOM 1296 O TYR A 165 -21.940 5.860 18.384 1.00 95.74 O \\\\nATOM 1297 CG TYR A 165 -24.828 2.636 18.631 1.00 95.74 C \\\\nATOM 1298 CD1 TYR A 165 -25.656 2.982 17.546 1.00 95.74 C \\\\nATOM 1299 CD2 TYR A 165 -24.897 1.347 19.187 1.00 95.74 C \\\\nATOM 1300 CE1 TYR A 165 -26.551 2.039 17.010 1.00 95.74 C \\\\nATOM 1301 CE2 TYR A 165 -25.770 0.394 18.630 1.00 95.74 C \\\\nATOM 1302 OH TYR A 165 -27.473 -0.173 17.044 1.00 95.74 O \\\\nATOM 1303 CZ TYR A 165 -26.611 0.741 17.555 1.00 95.74 C \\\\nATOM 1304 N HIS A 166 -20.311 4.438 18.983 1.00 96.55 N \\\\nATOM 1305 CA HIS A 166 -19.236 5.436 19.062 1.00 96.55 C \\\\nATOM 1306 C HIS A 166 -18.425 5.553 17.774 1.00 96.55 C \\\\nATOM 1307 CB HIS A 166 -18.339 5.141 20.265 1.00 96.55 C \\\\nATOM 1308 O HIS A 166 -17.483 6.337 17.705 1.00 96.55 O \\\\nATOM 1309 CG HIS A 166 -18.963 5.469 21.593 1.00 96.55 C \\\\nATOM 1310 CD2 HIS A 166 -20.246 5.881 21.816 1.00 96.55 C \\\\nATOM 1311 ND1 HIS A 166 -18.243 5.555 22.785 1.00 96.55 N \\\\nATOM 1312 CE1 HIS A 166 -19.104 6.056 23.681 1.00 96.55 C \\\\nATOM 1313 NE2 HIS A 166 -20.313 6.236 23.137 1.00 96.55 N \\\\nATOM 1314 N TYR A 167 -18.809 4.800 16.749 1.00 95.99 N \\\\nATOM 1315 CA TYR A 167 -18.234 4.870 15.418 1.00 95.99 C \\\\nATOM 1316 C TYR A 167 -19.323 5.244 14.415 1.00 95.99 C \\\\nATOM 1317 CB TYR A 167 -17.535 3.543 15.095 1.00 95.99 C \\\\nATOM 1318 O TYR A 167 -20.494 4.939 14.606 1.00 95.99 O \\\\nATOM 1319 CG TYR A 167 -16.391 3.227 16.045 1.00 95.99 C \\\\nATOM 1320 CD1 TYR A 167 -15.102 3.728 15.781 1.00 95.99 C \\\\nATOM 1321 CD2 TYR A 167 -16.626 2.488 17.222 1.00 95.99 C \\\\nATOM 1322 CE1 TYR A 167 -14.053 3.494 16.690 1.00 95.99 C \\\\nATOM 1323 CE2 TYR A 167 -15.583 2.263 18.142 1.00 95.99 C \\\\nATOM 1324 OH TYR A 167 -13.262 2.544 18.736 1.00 95.99 O \\\\nATOM 1325 CZ TYR A 167 -14.291 2.772 17.876 1.00 95.99 C \\\\nATOM 1326 N GLN A 168 -18.962 5.909 13.336 1.00 93.44 N \\\\nATOM 1327 CA GLN A 168 -19.802 6.190 12.182 1.00 93.44 C \\\\nATOM 1328 C GLN A 168 -19.122 5.567 10.971 1.00 93.44 C \\\\nATOM 1329 CB GLN A 168 -19.992 7.702 12.024 1.00 93.44 C \\\\nATOM 1330 O GLN A 168 -17.891 5.559 10.897 1.00 93.44 O \\\\nATOM 1331 CG GLN A 168 -20.874 8.284 13.141 1.00 93.44 C \\\\nATOM 1332 CD GLN A 168 -20.992 9.804 13.068 1.00 93.44 C \\\\nATOM 1333 NE2 GLN A 168 -21.814 10.413 13.894 1.00 93.44 N \\\\nATOM 1334 OE1 GLN A 168 -20.336 10.479 12.298 1.00 93.44 O \\\\nATOM 1335 N ARG A 169 -19.905 5.005 10.051 1.00 91.38 N \\\\nATOM 1336 CA ARG A 169 -19.352 4.515 8.793 1.00 91.38 C \\\\nATOM 1337 C ARG A 169 -18.992 5.723 7.940 1.00 91.38 C \\\\nATOM 1338 CB ARG A 169 -20.329 3.558 8.104 1.00 91.38 C \\\\nATOM 1339 O ARG A 169 -19.748 6.688 7.908 1.00 91.38 O \\\\nATOM 1340 CG ARG A 169 -19.688 2.835 6.915 1.00 91.38 C \\\\nATOM 1341 CD ARG A 169 -20.634 1.759 6.375 1.00 91.38 C \\\\nATOM 1342 NE ARG A 169 -19.942 0.894 5.407 1.00 91.38 N \\\\nATOM 1343 NH1 ARG A 169 -21.627 -0.625 5.046 1.00 91.38 N \\\\nATOM 1344 NH2 ARG A 169 -19.646 -0.939 4.109 1.00 91.38 N \\\\nATOM 1345 CZ ARG A 169 -20.411 -0.206 4.856 1.00 91.38 C \\\\nATOM 1346 N VAL A 170 -17.837 5.680 7.296 1.00 88.40 N \\\\nATOM 1347 CA VAL A 170 -17.450 6.695 6.318 1.00 88.40 C \\\\nATOM 1348 C VAL A 170 -18.362 6.528 5.104 1.00 88.40 C \\\\nATOM 1349 CB VAL A 170 -15.959 6.576 5.956 1.00 88.40 C \\\\nATOM 1350 O VAL A 170 -18.325 5.495 4.438 1.00 88.40 O \\\\nATOM 1351 CG1 VAL A 170 -15.564 7.639 4.927 1.00 88.40 C \\\\nATOM 1352 CG2 VAL A 170 -15.075 6.775 7.199 1.00 88.40 C \\\\nATOM 1353 N GLU A 171 -19.219 7.514 4.864 1.00 82.22 N \\\\nATOM 1354 CA GLU A 171 -20.124 7.540 3.715 1.00 82.22 C \\\\nATOM 1355 C GLU A 171 -19.408 8.133 2.499 1.00 82.22 C \\\\nATOM 1356 CB GLU A 171 -21.407 8.317 4.059 1.00 82.22 C \\\\nATOM 1357 O GLU A 171 -18.624 9.076 2.625 1.00 82.22 O \\\\nATOM 1358 CG GLU A 171 -22.244 7.575 5.118 1.00 82.22 C \\\\nATOM 1359 CD GLU A 171 -23.545 8.288 5.520 1.00 82.22 C \\\\nATOM 1360 OE1 GLU A 171 -24.246 7.719 6.392 1.00 82.22 O \\\\nATOM 1361 OE2 GLU A 171 -23.828 9.381 4.983 1.00 82.22 O \\\\nATOM 1362 N THR A 172 -19.669 7.580 1.313 1.00 80.03 N \\\\nATOM 1363 CA THR A 172 -19.195 8.172 0.059 1.00 80.03 C \\\\nATOM 1364 C THR A 172 -20.025 9.421 -0.233 1.00 80.03 C \\\\nATOM 1365 CB THR A 172 -19.256 7.179 -1.107 1.00 80.03 C \\\\nATOM 1366 O THR A 172 -21.246 9.310 -0.362 1.00 80.03 O \\\\nATOM 1367 CG2 THR A 172 -18.685 7.755 -2.404 1.00 80.03 C \\\\nATOM 1368 OG1 THR A 172 -18.475 6.045 -0.796 1.00 80.03 O \\\\nATOM 1369 N PRO A 173 -19.405 10.609 -0.330 1.00 80.47 N \\\\nATOM 1370 CA PRO A 173 -20.132 11.834 -0.616 1.00 80.47 C \\\\nATOM 1371 C PRO A 173 -20.764 11.762 -2.009 1.00 80.47 C \\\\nATOM 1372 CB PRO A 173 -19.098 12.954 -0.499 1.00 80.47 C \\\\nATOM 1373 O PRO A 173 -20.144 11.285 -2.960 1.00 80.47 O \\\\nATOM 1374 CG PRO A 173 -17.772 12.263 -0.826 1.00 80.47 C \\\\nATOM 1375 CD PRO A 173 -17.973 10.853 -0.292 1.00 80.47 C \\\\nATOM 1376 N VAL A 174 -21.991 12.272 -2.140 1.00 82.51 N \\\\nATOM 1377 CA VAL A 174 -22.652 12.398 -3.445 1.00 82.51 C \\\\nATOM 1378 C VAL A 174 -21.908 13.453 -4.264 1.00 82.51 C \\\\nATOM 1379 CB VAL A 174 -24.147 12.744 -3.305 1.00 82.51 C \\\\nATOM 1380 O VAL A 174 -21.784 14.602 -3.839 1.00 82.51 O \\\\nATOM 1381 CG1 VAL A 174 -24.830 12.822 -4.677 1.00 82.51 C \\\\nATOM 1382 CG2 VAL A 174 -24.885 11.685 -2.474 1.00 82.51 C \\\\nATOM 1383 N LEU A 175 -21.392 13.056 -5.426 1.00 85.88 N \\\\nATOM 1384 CA LEU A 175 -20.677 13.953 -6.333 1.00 85.88 C \\\\nATOM 1385 C LEU A 175 -21.683 14.739 -7.196 1.00 85.88 C \\\\nATOM 1386 CB LEU A 175 -19.685 13.147 -7.190 1.00 85.88 C \\\\nATOM 1387 O LEU A 175 -22.635 14.137 -7.702 1.00 85.88 O \\\\nATOM 1388 CG LEU A 175 -18.604 12.400 -6.386 1.00 85.88 C \\\\nATOM 1389 CD1 LEU A 175 -17.801 11.463 -7.283 1.00 85.88 C \\\\nATOM 1390 CD2 LEU A 175 -17.627 13.363 -5.708 1.00 85.88 C \\\\nATOM 1391 N PRO A 176 -21.506 16.062 -7.378 1.00 86.02 N \\\\nATOM 1392 CA PRO A 176 -22.392 16.857 -8.224 1.00 86.02 C \\\\nATOM 1393 C PRO A 176 -22.263 16.431 -9.698 1.00 86.02 C \\\\nATOM 1394 CB PRO A 176 -21.967 18.312 -8.009 1.00 86.02 C \\\\nATOM 1395 O PRO A 176 -21.165 16.064 -10.123 1.00 86.02 O \\\\nATOM 1396 CG PRO A 176 -20.483 18.195 -7.657 1.00 86.02 C \\\\nATOM 1397 CD PRO A 176 -20.411 16.882 -6.878 1.00 86.02 C \\\\nATOM 1398 N PRO A 177 -23.344 16.482 -10.499 1.00 87.29 N \\\\nATOM 1399 CA PRO A 177 -23.257 16.213 -11.931 1.00 87.29 C \\\\nATOM 1400 C PRO A 177 -22.373 17.251 -12.631 1.00 87.29 C \\\\nATOM 1401 CB PRO A 177 -24.697 16.255 -12.451 1.00 87.29 C \\\\nATOM 1402 O PRO A 177 -22.425 18.440 -12.314 1.00 87.29 O \\\\nATOM 1403 CG PRO A 177 -25.403 17.184 -11.463 1.00 87.29 C \\\\nATOM 1404 CD PRO A 177 -24.688 16.909 -10.139 1.00 87.29 C \\\\nATOM 1405 N VAL A 178 -21.600 16.805 -13.619 1.00 87.57 N \\\\nATOM 1406 CA VAL A 178 -20.834 17.696 -14.500 1.00 87.57 C \\\\nATOM 1407 C VAL A 178 -21.767 18.192 -15.599 1.00 87.57 C \\\\nATOM 1408 CB VAL A 178 -19.596 16.981 -15.070 1.00 87.57 C \\\\nATOM 1409 O VAL A 178 -22.409 17.384 -16.266 1.00 87.57 O \\\\nATOM 1410 CG1 VAL A 178 -18.864 17.835 -16.108 1.00 87.57 C \\\\nATOM 1411 CG2 VAL A 178 -18.600 16.666 -13.950 1.00 87.57 C \\\\nATOM 1412 N LEU A 179 -21.873 19.509 -15.769 1.00 87.79 N \\\\nATOM 1413 CA LEU A 179 -22.702 20.119 -16.808 1.00 87.79 C \\\\nATOM 1414 C LEU A 179 -21.874 20.288 -18.081 1.00 87.79 C \\\\nATOM 1415 CB LEU A 179 -23.254 21.470 -16.317 1.00 87.79 C \\\\nATOM 1416 O LEU A 179 -20.872 20.998 -18.060 1.00 87.79 O \\\\nATOM 1417 CG LEU A 179 -24.097 21.415 -15.032 1.00 87.79 C \\\\nATOM 1418 CD1 LEU A 179 -24.620 22.811 -14.697 1.00 87.79 C \\\\nATOM 1419 CD2 LEU A 179 -25.295 20.471 -15.156 1.00 87.79 C \\\\nATOM 1420 N VAL A 180 -22.289 19.647 -19.172 1.00 84.28 N \\\\nATOM 1421 CA VAL A 180 -21.601 19.720 -20.466 1.00 84.28 C \\\\nATOM 1422 C VAL A 180 -22.396 20.613 -21.422 1.00 84.28 C \\\\nATOM 1423 CB VAL A 180 -21.359 18.323 -21.065 1.00 84.28 C \\\\nATOM 1424 O VAL A 180 -23.571 20.321 -21.665 1.00 84.28 O \\\\nATOM 1425 CG1 VAL A 180 -20.531 18.447 -22.348 1.00 84.28 C \\\\nATOM 1426 CG2 VAL A 180 -20.586 17.436 -20.078 1.00 84.28 C \\\\nATOM 1427 N PRO A 181 -21.807 21.693 -21.967 1.00 78.12 N \\\\nATOM 1428 CA PRO A 181 -22.442 22.482 -23.017 1.00 78.12 C \\\\nATOM 1429 C PRO A 181 -22.627 21.643 -24.281 1.00 78.12 C \\\\nATOM 1430 CB PRO A 181 -21.519 23.687 -23.260 1.00 78.12 C \\\\nATOM 1431 O PRO A 181 -21.658 21.102 -24.813 1.00 78.12 O \\\\nATOM 1432 CG PRO A 181 -20.643 23.753 -22.010 1.00 78.12 C \\\\nATOM 1433 CD PRO A 181 -20.538 22.293 -21.584 1.00 78.12 C \\\\nATOM 1434 N ARG A 182 -23.855 21.550 -24.801 1.00 67.49 N \\\\nATOM 1435 CA ARG A 182 -24.062 21.007 -26.146 1.00 67.49 C \\\\nATOM 1436 C ARG A 182 -23.515 21.998 -27.170 1.00 67.49 C \\\\nATOM 1437 CB ARG A 182 -25.542 20.692 -26.386 1.00 67.49 C \\\\nATOM 1438 O ARG A 182 -23.953 23.146 -27.230 1.00 67.49 O \\\\nATOM 1439 CG ARG A 182 -25.978 19.452 -25.594 1.00 67.49 C \\\\nATOM 1440 CD ARG A 182 -27.438 19.144 -25.917 1.00 67.49 C \\\\nATOM 1441 NE ARG A 182 -27.885 17.885 -25.302 1.00 67.49 N \\\\nATOM 1442 NH1 ARG A 182 -30.126 18.198 -25.717 1.00 67.49 N \\\\nATOM 1443 NH2 ARG A 182 -29.440 16.332 -24.732 1.00 67.49 N \\\\nATOM 1444 CZ ARG A 182 -29.139 17.478 -25.265 1.00 67.49 C \\\\nATOM 1445 N HIS A 183 -22.548 21.562 -27.974 1.00 57.15 N \\\\nATOM 1446 CA HIS A 183 -22.051 22.350 -29.097 1.00 57.15 C \\\\nATOM 1447 C HIS A 183 -23.143 22.490 -30.162 1.00 57.15 C \\\\nATOM 1448 CB HIS A 183 -20.776 21.713 -29.680 1.00 57.15 C \\\\nATOM 1449 O HIS A 183 -23.293 21.614 -31.012 1.00 57.15 O \\\\nATOM 1450 CG HIS A 183 -19.515 22.141 -28.978 1.00 57.15 C \\\\nATOM 1451 CD2 HIS A 183 -18.673 21.359 -28.233 1.00 57.15 C \\\\nATOM 1452 ND1 HIS A 183 -18.973 23.407 -29.012 1.00 57.15 N \\\\nATOM 1453 CE1 HIS A 183 -17.836 23.388 -28.298 1.00 57.15 C \\\\nATOM 1454 NE2 HIS A 183 -17.608 22.162 -27.810 1.00 57.15 N \\\\nATOM 1455 N THR A 184 -23.876 23.605 -30.134 1.00 46.80 N \\\\nATOM 1456 CA THR A 184 -24.677 24.042 -31.286 1.00 46.80 C \\\\nATOM 1457 C THR A 184 -23.954 25.106 -32.118 1.00 46.80 C \\\\nATOM 1458 CB THR A 184 -26.113 24.462 -30.917 1.00 46.80 C \\\\nATOM 1459 O THR A 184 -24.179 25.140 -33.319 1.00 46.80 O \\\\nATOM 1460 CG2 THR A 184 -27.094 24.160 -32.053 1.00 46.80 C \\\\nATOM 1461 OG1 THR A 184 -26.596 23.744 -29.802 1.00 46.80 O \\\\nATOM 1462 N GLU A 185 -23.029 25.915 -31.574 1.00 42.59 N \\\\nATOM 1463 CA GLU A 185 -22.300 26.939 -32.355 1.00 42.59 C \\\\nATOM 1464 C GLU A 185 -20.865 27.188 -31.829 1.00 42.59 C \\\\nATOM 1465 CB GLU A 185 -23.118 28.248 -32.437 1.00 42.59 C \\\\nATOM 1466 O GLU A 185 -20.599 27.141 -30.628 1.00 42.59 O \\\\nATOM 1467 CG GLU A 185 -24.438 28.065 -33.220 1.00 42.59 C \\\\nATOM 1468 CD GLU A 185 -25.260 29.335 -33.440 1.00 42.59 C \\\\nATOM 1469 OE1 GLU A 185 -26.206 29.262 -34.258 1.00 42.59 O \\\\nATOM 1470 OE2 GLU A 185 -24.976 30.351 -32.769 1.00 42.59 O \\\\nATOM 1471 N ILE A 186 -19.920 27.403 -32.751 1.00 43.70 N \\\\nATOM 1472 CA ILE A 186 -18.473 27.564 -32.524 1.00 43.70 C \\\\nATOM 1473 C ILE A 186 -18.190 28.959 -31.940 1.00 43.70 C \\\\nATOM 1474 CB ILE A 186 -17.731 27.351 -33.876 1.00 43.70 C \\\\nATOM 1475 O ILE A 186 -18.321 29.960 -32.645 1.00 43.70 O \\\\nATOM 1476 CG1 ILE A 186 -17.917 25.903 -34.397 1.00 43.70 C \\\\nATOM 1477 CG2 ILE A 186 -16.227 27.681 -33.786 1.00 43.70 C \\\\nATOM 1478 CD1 ILE A 186 -17.621 25.743 -35.895 1.00 43.70 C \\\\nATOM 1479 N LEU A 187 -17.743 29.045 -30.682 1.00 41.65 N \\\\nATOM 1480 CA LEU A 187 -17.145 30.279 -30.164 1.00 41.65 C \\\\nATOM 1481 C LEU A 187 -15.734 30.433 -30.738 1.00 41.65 C \\\\nATOM 1482 CB LEU A 187 -17.170 30.334 -28.626 1.00 41.65 C \\\\nATOM 1483 O LEU A 187 -14.805 29.707 -30.389 1.00 41.65 O \\\\nATOM 1484 CG LEU A 187 -18.565 30.585 -28.022 1.00 41.65 C \\\\nATOM 1485 CD1 LEU A 187 -18.455 30.600 -26.497 1.00 41.65 C \\\\nATOM 1486 CD2 LEU A 187 -19.178 31.921 -28.456 1.00 41.65 C \\\\nATOM 1487 N THR A 188 -15.608 31.387 -31.655 1.00 39.88 N \\\\nATOM 1488 CA THR A 188 -14.369 31.743 -32.347 1.00 39.88 C \\\\nATOM 1489 C THR A 188 -13.667 32.847 -31.557 1.00 39.88 C \\\\nATOM 1490 CB THR A 188 -14.652 32.176 -33.805 1.00 39.88 C \\\\nATOM 1491 O THR A 188 -13.729 33.993 -31.963 1.00 39.88 O \\\\nATOM 1492 CG2 THR A 188 -13.409 32.051 -34.686 1.00 39.88 C \\\\nATOM 1493 OG1 THR A 188 -15.632 31.356 -34.407 1.00 39.88 O \\\\nATOM 1494 N GLU A 189 -13.096 32.520 -30.393 1.00 39.17 N \\\\nATOM 1495 CA GLU A 189 -12.008 33.261 -29.717 1.00 39.17 C \\\\nATOM 1496 C GLU A 189 -11.721 32.594 -28.357 1.00 39.17 C \\\\nATOM 1497 CB GLU A 189 -12.299 34.776 -29.537 1.00 39.17 C \\\\nATOM 1498 O GLU A 189 -12.476 32.743 -27.398 1.00 39.17 O \\\\nATOM 1499 CG GLU A 189 -11.503 35.615 -30.564 1.00 39.17 C \\\\nATOM 1500 CD GLU A 189 -11.864 37.112 -30.592 1.00 39.17 C \\\\nATOM 1501 OE1 GLU A 189 -11.347 37.804 -31.501 1.00 39.17 O \\\\nATOM 1502 OE2 GLU A 189 -12.600 37.578 -29.692 1.00 39.17 O \\\\nATOM 1503 N LEU A 190 -10.632 31.819 -28.274 1.00 46.02 N \\\\nATOM 1504 CA LEU A 190 -10.084 31.291 -27.019 1.00 46.02 C \\\\nATOM 1505 C LEU A 190 -8.787 32.052 -26.685 1.00 46.02 C \\\\nATOM 1506 CB LEU A 190 -9.839 29.770 -27.126 1.00 46.02 C \\\\nATOM 1507 O LEU A 190 -7.996 32.310 -27.598 1.00 46.02 O \\\\nATOM 1508 CG LEU A 190 -11.069 28.909 -26.773 1.00 46.02 C \\\\nATOM 1509 CD1 LEU A 190 -10.925 27.510 -27.372 1.00 46.02 C \\\\nATOM 1510 CD2 LEU A 190 -11.236 28.751 -25.258 1.00 46.02 C \\\\nATOM 1511 N PRO A 191 -8.544 32.405 -25.407 1.00 44.40 N \\\\nATOM 1512 CA PRO A 191 -7.281 32.997 -24.973 1.00 44.40 C \\\\nATOM 1513 C PRO A 191 -6.117 32.019 -25.213 1.00 44.40 C \\\\nATOM 1514 CB PRO A 191 -7.478 33.357 -23.496 1.00 44.40 C \\\\nATOM 1515 O PRO A 191 -6.349 30.810 -25.301 1.00 44.40 O \\\\nATOM 1516 CG PRO A 191 -8.582 32.417 -23.018 1.00 44.40 C \\\\nATOM 1517 CD PRO A 191 -9.399 32.116 -24.270 1.00 44.40 C \\\\nATOM 1518 N PRO A 192 -4.872 32.515 -25.343 1.00 44.87 N \\\\nATOM 1519 CA PRO A 192 -3.722 31.678 -25.668 1.00 44.87 C \\\\nATOM 1520 C PRO A 192 -3.588 30.547 -24.642 1.00 44.87 C \\\\nATOM 1521 CB PRO A 192 -2.510 32.619 -25.694 1.00 44.87 C \\\\nATOM 1522 O PRO A 192 -3.456 30.796 -23.446 1.00 44.87 O \\\\nATOM 1523 CG PRO A 192 -2.947 33.804 -24.832 1.00 44.87 C \\\\nATOM 1524 CD PRO A 192 -4.452 33.878 -25.071 1.00 44.87 C \\\\nATOM 1525 N LEU A 193 -3.669 29.307 -25.127 1.00 47.96 N \\\\nATOM 1526 CA LEU A 193 -3.348 28.114 -24.354 1.00 47.96 C \\\\nATOM 1527 C LEU A 193 -1.859 28.168 -24.002 1.00 47.96 C \\\\nATOM 1528 CB LEU A 193 -3.669 26.855 -25.189 1.00 47.96 C \\\\nATOM 1529 O LEU A 193 -1.025 28.289 -24.900 1.00 47.96 O \\\\nATOM 1530 CG LEU A 193 -5.169 26.516 -25.287 1.00 47.96 C \\\\nATOM 1531 CD1 LEU A 193 -5.420 25.532 -26.432 1.00 47.96 C \\\\nATOM 1532 CD2 LEU A 193 -5.678 25.874 -23.994 1.00 47.96 C \\\\nATOM 1533 N ASP A 194 -1.534 28.058 -22.714 1.00 43.48 N \\\\nATOM 1534 CA ASP A 194 -0.163 27.779 -22.297 1.00 43.48 C \\\\nATOM 1535 C ASP A 194 0.288 26.455 -22.931 1.00 43.48 C \\\\nATOM 1536 CB ASP A 194 -0.029 27.747 -20.764 1.00 43.48 C \\\\nATOM 1537 O ASP A 194 -0.447 25.463 -22.966 1.00 43.48 O \\\\nATOM 1538 CG ASP A 194 0.055 29.139 -20.120 1.00 43.48 C \\\\nATOM 1539 OD1 ASP A 194 0.655 30.045 -20.741 1.00 43.48 O \\\\nATOM 1540 OD2 ASP A 194 -0.427 29.269 -18.971 1.00 43.48 O \\\\nATOM 1541 N ASP A 195 1.502 26.463 -23.471 1.00 40.98 N \\\\nATOM 1542 CA ASP A 195 2.109 25.353 -24.193 1.00 40.98 C \\\\nATOM 1543 C ASP A 195 2.381 24.181 -23.226 1.00 40.98 C \\\\nATOM 1544 CB ASP A 195 3.357 25.896 -24.920 1.00 40.98 C \\\\nATOM 1545 O ASP A 195 3.425 24.073 -22.582 1.00 40.98 O \\\\nATOM 1546 CG ASP A 195 3.821 25.038 -26.099 1.00 40.98 C \\\\nATOM 1547 OD1 ASP A 195 3.338 23.887 -26.222 1.00 40.98 O \\\\nATOM 1548 OD2 ASP A 195 4.683 25.520 -26.864 1.00 40.98 O \\\\nATOM 1549 N TYR A 196 1.401 23.287 -23.074 1.00 45.99 N \\\\nATOM 1550 CA TYR A 196 1.498 22.073 -22.256 1.00 45.99 C \\\\nATOM 1551 C TYR A 196 2.280 20.949 -22.954 1.00 45.99 C \\\\nATOM 1552 CB TYR A 196 0.104 21.626 -21.782 1.00 45.99 C \\\\nATOM 1553 O TYR A 196 2.133 19.776 -22.601 1.00 45.99 O \\\\nATOM 1554 CG TYR A 196 -0.449 22.425 -20.621 1.00 45.99 C \\\\nATOM 1555 CD1 TYR A 196 0.004 22.188 -19.305 1.00 45.99 C \\\\nATOM 1556 CD2 TYR A 196 -1.435 23.397 -20.858 1.00 45.99 C \\\\nATOM 1557 CE1 TYR A 196 -0.532 22.927 -18.231 1.00 45.99 C \\\\nATOM 1558 CE2 TYR A 196 -1.974 24.134 -19.790 1.00 45.99 C \\\\nATOM 1559 OH TYR A 196 -2.055 24.617 -17.450 1.00 45.99 O \\\\nATOM 1560 CZ TYR A 196 -1.526 23.902 -18.477 1.00 45.99 C \\\\nATOM 1561 N THR A 197 3.168 21.259 -23.899 1.00 44.07 N \\\\nATOM 1562 CA THR A 197 4.138 20.294 -24.449 1.00 44.07 C \\\\nATOM 1563 C THR A 197 5.068 19.704 -23.373 1.00 44.07 C \\\\nATOM 1564 CB THR A 197 4.937 20.916 -25.605 1.00 44.07 C \\\\nATOM 1565 O THR A 197 5.636 18.633 -23.572 1.00 44.07 O \\\\nATOM 1566 CG2 THR A 197 4.119 20.933 -26.895 1.00 44.07 C \\\\nATOM 1567 OG1 THR A 197 5.316 22.233 -25.300 1.00 44.07 O \\\\nATOM 1568 N HIS A 198 5.111 20.292 -22.171 1.00 42.09 N \\\\nATOM 1569 CA HIS A 198 5.744 19.726 -20.969 1.00 42.09 C \\\\nATOM 1570 C HIS A 198 4.830 18.831 -20.098 1.00 42.09 C \\\\nATOM 1571 CB HIS A 198 6.354 20.877 -20.161 1.00 42.09 C \\\\nATOM 1572 O HIS A 198 5.241 18.362 -19.037 1.00 42.09 O \\\\nATOM 1573 CG HIS A 198 7.428 21.607 -20.924 1.00 42.09 C \\\\nATOM 1574 CD2 HIS A 198 7.425 22.924 -21.302 1.00 42.09 C \\\\nATOM 1575 ND1 HIS A 198 8.589 21.047 -21.409 1.00 42.09 N \\\\nATOM 1576 CE1 HIS A 198 9.273 22.005 -22.054 1.00 42.09 C \\\\nATOM 1577 NE2 HIS A 198 8.615 23.170 -21.994 1.00 42.09 N \\\\nATOM 1578 N SER A 199 3.585 18.569 -20.513 1.00 43.75 N \\\\nATOM 1579 CA SER A 199 2.611 17.784 -19.731 1.00 43.75 C \\\\nATOM 1580 C SER A 199 2.780 16.269 -19.848 1.00 43.75 C \\\\nATOM 1581 CB SER A 199 1.176 18.147 -20.110 1.00 43.75 C \\\\nATOM 1582 O SER A 199 2.189 15.538 -19.049 1.00 43.75 O \\\\nATOM 1583 OG SER A 199 0.904 17.723 -21.433 1.00 43.75 O \\\\nATOM 1584 N ILE A 200 3.559 15.781 -20.821 1.00 42.94 N \\\\nATOM 1585 CA ILE A 200 4.083 14.414 -20.812 1.00 42.94 C \\\\nATOM 1586 C ILE A 200 5.367 14.491 -20.005 1.00 42.94 C \\\\nATOM 1587 CB ILE A 200 4.378 13.862 -22.226 1.00 42.94 C \\\\nATOM 1588 O ILE A 200 6.360 15.025 -20.501 1.00 42.94 O \\\\nATOM 1589 CG1 ILE A 200 3.113 13.892 -23.105 1.00 42.94 C \\\\nATOM 1590 CG2 ILE A 200 4.921 12.419 -22.113 1.00 42.94 C \\\\nATOM 1591 CD1 ILE A 200 3.385 13.574 -24.580 1.00 42.94 C \\\\nATOM 1592 N PRO A 201 5.411 13.973 -18.773 1.00 48.89 N \\\\nATOM 1593 CA PRO A 201 6.698 13.882 -18.145 1.00 48.89 C \\\\nATOM 1594 C PRO A 201 7.513 12.838 -18.892 1.00 48.89 C \\\\nATOM 1595 CB PRO A 201 6.435 13.536 -16.703 1.00 48.89 C \\\\nATOM 1596 O PRO A 201 7.066 11.701 -19.058 1.00 48.89 O \\\\nATOM 1597 CG PRO A 201 4.922 13.301 -16.558 1.00 48.89 C \\\\nATOM 1598 CD PRO A 201 4.381 13.323 -17.983 1.00 48.89 C \\\\nATOM 1599 N GLU A 202 8.725 13.207 -19.300 1.00 54.78 N \\\\nATOM 1600 CA GLU A 202 9.679 12.321 -19.981 1.00 54.78 C \\\\nATOM 1601 C GLU A 202 9.876 10.989 -19.236 1.00 54.78 C \\\\nATOM 1602 CB GLU A 202 11.032 13.036 -20.092 1.00 54.78 C \\\\nATOM 1603 O GLU A 202 10.212 9.968 -19.833 1.00 54.78 O \\\\nATOM 1604 CG GLU A 202 11.007 14.228 -21.061 1.00 54.78 C \\\\nATOM 1605 CD GLU A 202 12.381 14.908 -21.171 1.00 54.78 C \\\\nATOM 1606 OE1 GLU A 202 12.648 15.502 -22.237 1.00 54.78 O \\\\nATOM 1607 OE2 GLU A 202 13.154 14.818 -20.188 1.00 54.78 O \\\\nATOM 1608 N ASN A 203 9.570 10.956 -17.934 1.00 64.59 N \\\\nATOM 1609 CA ASN A 203 9.573 9.748 -17.121 1.00 64.59 C \\\\nATOM 1610 C ASN A 203 8.459 8.712 -17.415 1.00 64.59 C \\\\nATOM 1611 CB ASN A 203 9.696 10.114 -15.636 1.00 64.59 C \\\\nATOM 1612 O ASN A 203 8.453 7.652 -16.776 1.00 64.59 O \\\\nATOM 1613 CG ASN A 203 8.514 10.710 -14.914 1.00 64.59 C \\\\nATOM 1614 ND2 ASN A 203 8.751 11.229 -13.733 1.00 64.59 N \\\\nATOM 1615 OD1 ASN A 203 7.370 10.626 -15.308 1.00 64.59 O \\\\nATOM 1616 N THR A 204 7.555 8.980 -18.366 1.00 56.41 N \\\\nATOM 1617 CA THR A 204 6.367 8.156 -18.675 1.00 56.41 C \\\\nATOM 1618 C THR A 204 6.367 7.475 -20.049 1.00 56.41 C \\\\nATOM 1619 CB THR A 204 5.059 8.951 -18.512 1.00 56.41 C \\\\nATOM 1620 O THR A 204 5.433 6.726 -20.332 1.00 56.41 O \\\\nATOM 1621 CG2 THR A 204 4.880 9.530 -17.113 1.00 56.41 C \\\\nATOM 1622 OG1 THR A 204 4.971 10.026 -19.414 1.00 56.41 O \\\\nATOM 1623 N ASN A 205 7.384 7.676 -20.897 1.00 49.30 N \\\\nATOM 1624 CA ASN A 205 7.339 7.163 -22.271 1.00 49.30 C \\\\nATOM 1625 C ASN A 205 7.411 5.624 -22.351 1.00 49.30 C \\\\nATOM 1626 CB ASN A 205 8.401 7.859 -23.157 1.00 49.30 C \\\\nATOM 1627 O ASN A 205 8.383 4.995 -21.919 1.00 49.30 O \\\\nATOM 1628 CG ASN A 205 7.823 8.911 -24.097 1.00 49.30 C \\\\nATOM 1629 ND2 ASN A 205 8.634 9.491 -24.948 1.00 49.30 N \\\\nATOM 1630 OD1 ASN A 205 6.647 9.226 -24.088 1.00 49.30 O \\\\nATOM 1631 N PHE A 206 6.385 5.039 -22.974 1.00 41.13 N \\\\nATOM 1632 CA PHE A 206 6.423 3.713 -23.590 1.00 41.13 C \\\\nATOM 1633 C PHE A 206 6.857 3.858 -25.057 1.00 41.13 C \\\\nATOM 1634 CB PHE A 206 5.035 3.059 -23.535 1.00 41.13 C \\\\nATOM 1635 O PHE A 206 6.550 4.880 -25.673 1.00 41.13 O \\\\nATOM 1636 CG PHE A 206 4.514 2.747 -22.147 1.00 41.13 C \\\\nATOM 1637 CD1 PHE A 206 4.761 1.489 -21.561 1.00 41.13 C \\\\nATOM 1638 CD2 PHE A 206 3.716 3.689 -21.474 1.00 41.13 C \\\\nATOM 1639 CE1 PHE A 206 4.166 1.158 -20.330 1.00 41.13 C \\\\nATOM 1640 CE2 PHE A 206 3.120 3.357 -20.247 1.00 41.13 C \\\\nATOM 1641 CZ PHE A 206 3.318 2.084 -19.694 1.00 41.13 C \\\\nATOM 1642 N PRO A 207 7.522 2.860 -25.663 1.00 35.10 N \\\\nATOM 1643 CA PRO A 207 7.728 2.862 -27.104 1.00 35.10 C \\\\nATOM 1644 C PRO A 207 6.383 2.618 -27.804 1.00 35.10 C \\\\nATOM 1645 CB PRO A 207 8.771 1.770 -27.363 1.00 35.10 C \\\\nATOM 1646 O PRO A 207 5.911 1.486 -27.892 1.00 35.10 O \\\\nATOM 1647 CG PRO A 207 8.559 0.782 -26.214 1.00 35.10 C \\\\nATOM 1648 CD PRO A 207 8.049 1.647 -25.059 1.00 35.10 C \\\\nATOM 1649 N ALA A 208 5.752 3.680 -28.303 1.00 33.84 N \\\\nATOM 1650 CA ALA A 208 4.773 3.562 -29.375 1.00 33.84 C \\\\nATOM 1651 C ALA A 208 5.554 3.220 -30.654 1.00 33.84 C \\\\nATOM 1652 CB ALA A 208 3.977 4.870 -29.479 1.00 33.84 C \\\\nATOM 1653 O ALA A 208 6.194 4.086 -31.242 1.00 33.84 O \\\\nATOM 1654 N GLY A 209 5.598 1.936 -31.016 1.00 29.29 N \\\\nATOM 1655 CA GLY A 209 6.338 1.481 -32.193 1.00 29.29 C \\\\nATOM 1656 C GLY A 209 6.670 -0.006 -32.166 1.00 29.29 C \\\\nATOM 1657 O GLY A 209 7.836 -0.376 -32.081 1.00 29.29 O \\\\nATOM 1658 N ILE A 210 5.653 -0.865 -32.237 1.00 34.22 N \\\\nATOM 1659 CA ILE A 210 5.816 -2.192 -32.838 1.00 34.22 C \\\\nATOM 1660 C ILE A 210 4.875 -2.199 -34.036 1.00 34.22 C \\\\nATOM 1661 CB ILE A 210 5.576 -3.353 -31.843 1.00 34.22 C \\\\nATOM 1662 O ILE A 210 3.655 -2.203 -33.873 1.00 34.22 O \\\\nATOM 1663 CG1 ILE A 210 6.570 -3.264 -30.660 1.00 34.22 C \\\\nATOM 1664 CG2 ILE A 210 5.729 -4.704 -32.570 1.00 34.22 C \\\\nATOM 1665 CD1 ILE A 210 6.384 -4.344 -29.585 1.00 34.22 C \\\\nATOM 1666 N GLU A 211 5.458 -2.118 -35.229 1.00 29.47 N \\\\nATOM 1667 CA GLU A 211 4.771 -2.379 -36.491 1.00 29.47 C \\\\nATOM 1668 C GLU A 211 4.011 -3.714 -36.392 1.00 29.47 C \\\\nATOM 1669 CB GLU A 211 5.802 -2.499 -37.624 1.00 29.47 C \\\\nATOM 1670 O GLU A 211 4.579 -4.702 -35.910 1.00 29.47 O \\\\nATOM 1671 CG GLU A 211 6.550 -1.198 -37.940 1.00 29.47 C \\\\nATOM 1672 CD GLU A 211 7.571 -1.409 -39.071 1.00 29.47 C \\\\nATOM 1673 OE1 GLU A 211 7.591 -0.576 -40.002 1.00 29.47 O \\\\nATOM 1674 OE2 GLU A 211 8.328 -2.405 -38.988 1.00 29.47 O \\\\nATOM 1675 N PRO A 212 2.747 -3.800 -36.837 1.00 32.98 N \\\\nATOM 1676 CA PRO A 212 2.040 -5.065 -36.836 1.00 32.98 C \\\\nATOM 1677 C PRO A 212 2.586 -5.915 -37.986 1.00 32.98 C \\\\nATOM 1678 CB PRO A 212 0.560 -4.696 -36.957 1.00 32.98 C \\\\nATOM 1679 O PRO A 212 2.143 -5.812 -39.129 1.00 32.98 O \\\\nATOM 1680 CG PRO A 212 0.579 -3.395 -37.760 1.00 32.98 C \\\\nATOM 1681 CD PRO A 212 1.919 -2.746 -37.402 1.00 32.98 C \\\\nATOM 1682 N GLN A 213 3.550 -6.788 -37.688 1.00 33.15 N \\\\nATOM 1683 CA GLN A 213 3.832 -7.926 -38.553 1.00 33.15 C \\\\nATOM 1684 C GLN A 213 2.620 -8.861 -38.511 1.00 33.15 C \\\\nATOM 1685 CB GLN A 213 5.141 -8.631 -38.170 1.00 33.15 C \\\\nATOM 1686 O GLN A 213 2.426 -9.630 -37.572 1.00 33.15 O \\\\nATOM 1687 CG GLN A 213 6.360 -7.846 -38.680 1.00 33.15 C \\\\nATOM 1688 CD GLN A 213 7.684 -8.575 -38.463 1.00 33.15 C \\\\nATOM 1689 NE2 GLN A 213 8.735 -8.163 -39.138 1.00 33.15 N \\\\nATOM 1690 OE1 GLN A 213 7.815 -9.515 -37.695 1.00 33.15 O \\\\nATOM 1691 N SER A 214 1.776 -8.698 -39.530 1.00 28.82 N \\\\nATOM 1692 CA SER A 214 0.949 -9.711 -40.183 1.00 28.82 C \\\\nATOM 1693 C SER A 214 0.850 -11.054 -39.449 1.00 28.82 C \\\\nATOM 1694 CB SER A 214 1.532 -9.943 -41.589 1.00 28.82 C \\\\nATOM 1695 O SER A 214 1.736 -11.894 -39.588 1.00 28.82 O \\\\nATOM 1696 OG SER A 214 2.881 -10.376 -41.529 1.00 28.82 O \\\\nATOM 1697 N ASN A 215 -0.261 -11.301 -38.753 1.00 34.40 N \\\\nATOM 1698 CA ASN A 215 -0.771 -12.656 -38.568 1.00 34.40 C \\\\nATOM 1699 C ASN A 215 -2.291 -12.627 -38.360 1.00 34.40 C \\\\nATOM 1700 CB ASN A 215 -0.009 -13.410 -37.457 1.00 34.40 C \\\\nATOM 1701 O ASN A 215 -2.806 -12.058 -37.404 1.00 34.40 O \\\\nATOM 1702 CG ASN A 215 1.130 -14.267 -38.005 1.00 34.40 C \\\\nATOM 1703 ND2 ASN A 215 2.151 -14.511 -37.219 1.00 34.40 N \\\\nATOM 1704 OD1 ASN A 215 1.103 -14.773 -39.116 1.00 34.40 O \\\\nATOM 1705 N TYR A 216 -2.961 -13.225 -39.344 1.00 29.75 N \\\\nATOM 1706 CA TYR A 216 -4.365 -13.598 -39.470 1.00 29.75 C \\\\nATOM 1707 C TYR A 216 -5.182 -13.675 -38.168 1.00 29.75 C \\\\nATOM 1708 CB TYR A 216 -4.356 -14.989 -40.129 1.00 29.75 C \\\\nATOM 1709 O TYR A 216 -4.917 -14.511 -37.307 1.00 29.75 O \\\\nATOM 1710 CG TYR A 216 -4.028 -14.992 -41.611 1.00 29.75 C \\\\nATOM 1711 CD1 TYR A 216 -5.088 -15.091 -42.531 1.00 29.75 C \\\\nATOM 1712 CD2 TYR A 216 -2.697 -14.914 -42.080 1.00 29.75 C \\\\nATOM 1713 CE1 TYR A 216 -4.830 -15.108 -43.913 1.00 29.75 C \\\\nATOM 1714 CE2 TYR A 216 -2.437 -14.907 -43.466 1.00 29.75 C \\\\nATOM 1715 OH TYR A 216 -3.271 -15.017 -45.721 1.00 29.75 O \\\\nATOM 1716 CZ TYR A 216 -3.507 -15.008 -44.384 1.00 29.75 C \\\\nATOM 1717 N ILE A 217 -6.277 -12.912 -38.117 1.00 36.30 N \\\\nATOM 1718 CA ILE A 217 -7.477 -13.261 -37.345 1.00 36.30 C \\\\nATOM 1719 C ILE A 217 -8.657 -13.233 -38.337 1.00 36.30 C \\\\nATOM 1720 CB ILE A 217 -7.702 -12.323 -36.136 1.00 36.30 C \\\\nATOM 1721 O ILE A 217 -8.815 -12.221 -39.022 1.00 36.30 O \\\\nATOM 1722 CG1 ILE A 217 -6.452 -12.275 -35.225 1.00 36.30 C \\\\nATOM 1723 CG2 ILE A 217 -8.930 -12.810 -35.341 1.00 36.30 C \\\\nATOM 1724 CD1 ILE A 217 -6.571 -11.314 -34.035 1.00 36.30 C \\\\nATOM 1725 N PRO A 218 -9.443 -14.318 -38.481 1.00 32.96 N \\\\nATOM 1726 CA PRO A 218 -10.608 -14.346 -39.360 1.00 32.96 C \\\\nATOM 1727 C PRO A 218 -11.803 -13.572 -38.782 1.00 32.96 C \\\\nATOM 1728 CB PRO A 218 -10.946 -15.820 -39.605 1.00 32.96 C \\\\nATOM 1729 O PRO A 218 -11.941 -13.411 -37.572 1.00 32.96 O \\\\nATOM 1730 CG PRO A 218 -10.051 -16.621 -38.658 1.00 32.96 C \\\\nATOM 1731 CD PRO A 218 -9.295 -15.598 -37.813 1.00 32.96 C \\\\nATOM 1732 N GLU A 219 -12.654 -13.127 -39.705 1.00 30.87 N \\\\nATOM 1733 CA GLU A 219 -13.843 -12.283 -39.574 1.00 30.87 C \\\\nATOM 1734 C GLU A 219 -14.855 -12.670 -38.479 1.00 30.87 C \\\\nATOM 1735 CB GLU A 219 -14.609 -12.357 -40.910 1.00 30.87 C \\\\nATOM 1736 O GLU A 219 -15.227 -13.832 -38.327 1.00 30.87 O \\\\nATOM 1737 CG GLU A 219 -13.824 -11.896 -42.144 1.00 30.87 C \\\\nATOM 1738 CD GLU A 219 -14.698 -12.002 -43.401 1.00 30.87 C \\\\nATOM 1739 OE1 GLU A 219 -14.979 -10.943 -44.004 1.00 30.87 O \\\\nATOM 1740 OE2 GLU A 219 -15.076 -13.146 -43.743 1.00 30.87 O \\\\nATOM 1741 N THR A 220 -15.441 -11.649 -37.848 1.00 36.68 N \\\\nATOM 1742 CA THR A 220 -16.836 -11.658 -37.378 1.00 36.68 C \\\\nATOM 1743 C THR A 220 -17.442 -10.258 -37.576 1.00 36.68 C \\\\nATOM 1744 CB THR A 220 -17.000 -12.083 -35.902 1.00 36.68 C \\\\nATOM 1745 O THR A 220 -16.932 -9.297 -36.999 1.00 36.68 O \\\\nATOM 1746 CG2 THR A 220 -17.311 -13.572 -35.758 1.00 36.68 C \\\\nATOM 1747 OG1 THR A 220 -15.859 -11.832 -35.113 1.00 36.68 O \\\\nATOM 1748 N PRO A 221 -18.508 -10.089 -38.385 1.00 42.32 N \\\\nATOM 1749 CA PRO A 221 -19.201 -8.809 -38.514 1.00 42.32 C \\\\nATOM 1750 C PRO A 221 -20.236 -8.633 -37.382 1.00 42.32 C \\\\nATOM 1751 CB PRO A 221 -19.847 -8.851 -39.900 1.00 42.32 C \\\\nATOM 1752 O PRO A 221 -20.784 -9.632 -36.904 1.00 42.32 O \\\\nATOM 1753 CG PRO A 221 -20.189 -10.332 -40.078 1.00 42.32 C \\\\nATOM 1754 CD PRO A 221 -19.111 -11.072 -39.279 1.00 42.32 C \\\\nATOM 1755 N PRO A 222 -20.556 -7.399 -36.941 1.00 47.76 N \\\\nATOM 1756 CA PRO A 222 -21.640 -7.176 -35.990 1.00 47.76 C \\\\nATOM 1757 C PRO A 222 -23.023 -7.337 -36.662 1.00 47.76 C \\\\nATOM 1758 CB PRO A 222 -21.442 -5.774 -35.404 1.00 47.76 C \\\\nATOM 1759 O PRO A 222 -23.148 -7.094 -37.864 1.00 47.76 O \\\\nATOM 1760 CG PRO A 222 -20.184 -5.225 -36.082 1.00 47.76 C \\\\nATOM 1761 CD PRO A 222 -19.949 -6.129 -37.291 1.00 47.76 C \\\\nATOM 1762 N PRO A 223 -24.074 -7.726 -35.913 1.00 42.45 N \\\\nATOM 1763 CA PRO A 223 -25.353 -8.184 -36.465 1.00 42.45 C \\\\nATOM 1764 C PRO A 223 -26.228 -7.049 -37.015 1.00 42.45 C \\\\nATOM 1765 CB PRO A 223 -26.073 -8.914 -35.318 1.00 42.45 C \\\\nATOM 1766 O PRO A 223 -26.425 -6.032 -36.351 1.00 42.45 O \\\\nATOM 1767 CG PRO A 223 -25.013 -9.078 -34.231 1.00 42.45 C \\\\nATOM 1768 CD PRO A 223 -24.088 -7.897 -34.472 1.00 42.45 C \\\\nATOM 1769 N GLY A 224 -26.819 -7.264 -38.195 1.00 31.26 N \\\\nATOM 1770 CA GLY A 224 -27.895 -6.433 -38.735 1.00 31.26 C \\\\nATOM 1771 C GLY A 224 -29.232 -6.735 -38.057 1.00 31.26 C \\\\nATOM 1772 O GLY A 224 -29.611 -7.898 -37.926 1.00 31.26 O \\\\nATOM 1773 N TYR A 225 -29.949 -5.687 -37.649 1.00 42.75 N \\\\nATOM 1774 CA TYR A 225 -31.335 -5.777 -37.197 1.00 42.75 C \\\\nATOM 1775 C TYR A 225 -32.252 -5.158 -38.255 1.00 42.75 C \\\\nATOM 1776 CB TYR A 225 -31.515 -5.177 -35.793 1.00 42.75 C \\\\nATOM 1777 O TYR A 225 -32.238 -3.956 -38.508 1.00 42.75 O \\\\nATOM 1778 CG TYR A 225 -32.127 -6.155 -34.804 1.00 42.75 C \\\\nATOM 1779 CD1 TYR A 225 -33.524 -6.206 -34.627 1.00 42.75 C \\\\nATOM 1780 CD2 TYR A 225 -31.296 -7.033 -34.081 1.00 42.75 C \\\\nATOM 1781 CE1 TYR A 225 -34.087 -7.112 -33.708 1.00 42.75 C \\\\nATOM 1782 CE2 TYR A 225 -31.855 -7.941 -33.160 1.00 42.75 C \\\\nATOM 1783 OH TYR A 225 -33.792 -8.853 -32.080 1.00 42.75 O \\\\nATOM 1784 CZ TYR A 225 -33.252 -7.978 -32.969 1.00 42.75 C \\\\nATOM 1785 N ILE A 226 -32.999 -6.051 -38.888 1.00 36.55 N \\\\nATOM 1786 CA ILE A 226 -34.214 -5.839 -39.670 1.00 36.55 C \\\\nATOM 1787 C ILE A 226 -35.349 -5.370 -38.745 1.00 36.55 C \\\\nATOM 1788 CB ILE A 226 -34.596 -7.182 -40.357 1.00 36.55 C \\\\nATOM 1789 O ILE A 226 -35.517 -5.922 -37.659 1.00 36.55 O \\\\nATOM 1790 CG1 ILE A 226 -34.358 -8.412 -39.430 1.00 36.55 C \\\\nATOM 1791 CG2 ILE A 226 -33.797 -7.334 -41.664 1.00 36.55 C \\\\nATOM 1792 CD1 ILE A 226 -34.952 -9.729 -39.929 1.00 36.55 C \\\\nATOM 1793 N SER A 227 -36.143 -4.400 -39.199 1.00 47.93 N \\\\nATOM 1794 CA SER A 227 -37.483 -4.130 -38.667 1.00 47.93 C \\\\nATOM 1795 C SER A 227 -38.434 -3.907 -39.840 1.00 47.93 C \\\\nATOM 1796 CB SER A 227 -37.516 -2.924 -37.725 1.00 47.93 C \\\\nATOM 1797 O SER A 227 -38.234 -2.993 -40.640 1.00 47.93 O \\\\nATOM 1798 OG SER A 227 -36.754 -3.159 -36.553 1.00 47.93 O \\\\nATOM 1799 N GLU A 228 -39.414 -4.800 -39.935 1.00 46.11 N \\\\nATOM 1800 CA GLU A 228 -40.514 -4.858 -40.896 1.00 46.11 C \\\\nATOM 1801 C GLU A 228 -41.667 -3.894 -40.525 1.00 46.11 C \\\\nATOM 1802 CB GLU A 228 -41.021 -6.321 -40.936 1.00 46.11 C \\\\nATOM 1803 O GLU A 228 -41.901 -3.624 -39.349 1.00 46.11 O \\\\nATOM 1804 CG GLU A 228 -40.045 -7.298 -41.618 1.00 46.11 C \\\\nATOM 1805 CD GLU A 228 -40.428 -8.779 -41.415 1.00 46.11 C \\\\nATOM 1806 OE1 GLU A 228 -40.687 -9.476 -42.424 1.00 46.11 O \\\\nATOM 1807 OE2 GLU A 228 -40.337 -9.242 -40.252 1.00 46.11 O \\\\nATOM 1808 N ASP A 229 -42.363 -3.439 -41.575 1.00 43.27 N \\\\nATOM 1809 CA ASP A 229 -43.800 -3.134 -41.730 1.00 43.27 C \\\\nATOM 1810 C ASP A 229 -44.535 -2.042 -40.918 1.00 43.27 C \\\\nATOM 1811 CB ASP A 229 -44.587 -4.454 -41.742 1.00 43.27 C \\\\nATOM 1812 O ASP A 229 -44.500 -1.981 -39.691 1.00 43.27 O \\\\nATOM 1813 CG ASP A 229 -44.099 -5.419 -42.832 1.00 43.27 C \\\\nATOM 1814 OD1 ASP A 229 -43.547 -4.923 -43.845 1.00 43.27 O \\\\nATOM 1815 OD2 ASP A 229 -44.293 -6.638 -42.646 1.00 43.27 O \\\\nATOM 1816 N GLY A 230 -45.339 -1.235 -41.644 1.00 41.83 N \\\\nATOM 1817 CA GLY A 230 -46.419 -0.420 -41.058 1.00 41.83 C \\\\nATOM 1818 C GLY A 230 -46.959 0.792 -41.851 1.00 41.83 C \\\\nATOM 1819 O GLY A 230 -46.917 1.899 -41.337 1.00 41.83 O \\\\nATOM 1820 N GLU A 231 -47.436 0.576 -43.083 1.00 42.15 N \\\\nATOM 1821 CA GLU A 231 -48.653 1.121 -43.747 1.00 42.15 C \\\\nATOM 1822 C GLU A 231 -49.152 2.603 -43.629 1.00 42.15 C \\\\nATOM 1823 CB GLU A 231 -49.811 0.155 -43.417 1.00 42.15 C \\\\nATOM 1824 O GLU A 231 -49.428 3.117 -42.550 1.00 42.15 O \\\\nATOM 1825 CG GLU A 231 -49.540 -1.282 -43.904 1.00 42.15 C \\\\nATOM 1826 CD GLU A 231 -50.767 -2.196 -43.772 1.00 42.15 C \\\\nATOM 1827 OE1 GLU A 231 -51.040 -2.932 -44.747 1.00 42.15 O \\\\nATOM 1828 OE2 GLU A 231 -51.429 -2.146 -42.712 1.00 42.15 O \\\\nATOM 1829 N THR A 232 -49.529 3.161 -44.808 1.00 42.91 N \\\\nATOM 1830 CA THR A 232 -50.599 4.171 -45.128 1.00 42.91 C \\\\nATOM 1831 C THR A 232 -50.304 5.675 -44.888 1.00 42.91 C \\\\nATOM 1832 CB THR A 232 -51.949 3.746 -44.514 1.00 42.91 C \\\\nATOM 1833 O THR A 232 -49.792 6.040 -43.845 1.00 42.91 O \\\\nATOM 1834 CG2 THR A 232 -52.463 2.399 -45.036 1.00 42.91 C \\\\nATOM 1835 OG1 THR A 232 -51.949 3.754 -43.110 1.00 42.91 O \\\\nATOM 1836 N SER A 233 -50.593 6.665 -45.754 1.00 42.08 N \\\\nATOM 1837 CA SER A 233 -51.392 6.803 -46.990 1.00 42.08 C \\\\nATOM 1838 C SER A 233 -50.855 7.944 -47.882 1.00 42.08 C \\\\nATOM 1839 CB SER A 233 -52.827 7.235 -46.655 1.00 42.08 C \\\\nATOM 1840 O SER A 233 -50.367 8.956 -47.382 1.00 42.08 O \\\\nATOM 1841 OG SER A 233 -53.568 6.191 -46.074 1.00 42.08 O \\\\nATOM 1842 N ASP A 234 -51.034 7.784 -49.195 1.00 37.27 N \\\\nATOM 1843 CA ASP A 234 -50.823 8.764 -50.269 1.00 37.27 C \\\\nATOM 1844 C ASP A 234 -51.973 9.792 -50.428 1.00 37.27 C \\\\nATOM 1845 CB ASP A 234 -50.708 7.975 -51.598 1.00 37.27 C \\\\nATOM 1846 O ASP A 234 -53.094 9.568 -49.971 1.00 37.27 O \\\\nATOM 1847 CG ASP A 234 -49.301 7.534 -51.967 1.00 37.27 C \\\\nATOM 1848 OD1 ASP A 234 -48.425 8.425 -51.963 1.00 37.27 O \\\\nATOM 1849 OD2 ASP A 234 -49.159 6.359 -52.367 1.00 37.27 O \\\\nATOM 1850 N GLN A 235 -51.692 10.795 -51.282 1.00 43.07 N \\\\nATOM 1851 CA GLN A 235 -52.589 11.706 -52.035 1.00 43.07 C \\\\nATOM 1852 C GLN A 235 -52.955 13.016 -51.294 1.00 43.07 C \\\\nATOM 1853 CB GLN A 235 -53.801 10.947 -52.638 1.00 43.07 C \\\\nATOM 1854 O GLN A 235 -53.390 12.989 -50.157 1.00 43.07 O \\\\nATOM 1855 CG GLN A 235 -53.418 9.621 -53.332 1.00 43.07 C \\\\nATOM 1856 CD GLN A 235 -54.524 8.941 -54.125 1.00 43.07 C \\\\nATOM 1857 NE2 GLN A 235 -54.307 7.709 -54.536 1.00 43.07 N \\\\nATOM 1858 OE1 GLN A 235 -55.570 9.491 -54.427 1.00 43.07 O \\\\nATOM 1859 N GLN A 236 -52.828 14.231 -51.848 1.00 40.77 N \\\\nATOM 1860 CA GLN A 236 -53.079 14.661 -53.225 1.00 40.77 C \\\\nATOM 1861 C GLN A 236 -52.575 16.115 -53.450 1.00 40.77 C \\\\nATOM 1862 CB GLN A 236 -54.617 14.612 -53.409 1.00 40.77 C \\\\nATOM 1863 O GLN A 236 -52.714 16.948 -52.564 1.00 40.77 O \\\\nATOM 1864 CG GLN A 236 -55.092 14.033 -54.742 1.00 40.77 C \\\\nATOM 1865 CD GLN A 236 -56.567 13.641 -54.715 1.00 40.77 C \\\\nATOM 1866 NE2 GLN A 236 -57.005 12.779 -55.602 1.00 40.77 N \\\\nATOM 1867 OE1 GLN A 236 -57.365 14.104 -53.921 1.00 40.77 O \\\\nATOM 1868 N LEU A 237 -51.998 16.353 -54.642 1.00 40.25 N \\\\nATOM 1869 CA LEU A 237 -51.968 17.543 -55.533 1.00 40.25 C \\\\nATOM 1870 C LEU A 237 -52.324 18.968 -55.019 1.00 40.25 C \\\\nATOM 1871 CB LEU A 237 -52.972 17.219 -56.665 1.00 40.25 C \\\\nATOM 1872 O LEU A 237 -53.214 19.127 -54.205 1.00 40.25 O \\\\nATOM 1873 CG LEU A 237 -52.494 16.164 -57.685 1.00 40.25 C \\\\nATOM 1874 CD1 LEU A 237 -53.184 14.814 -57.499 1.00 40.25 C \\\\nATOM 1875 CD2 LEU A 237 -52.813 16.621 -59.108 1.00 40.25 C \\\\nATOM 1876 N ASN A 238 -51.915 20.102 -55.611 1.00 38.01 N \\\\nATOM 1877 CA ASN A 238 -50.938 20.586 -56.609 1.00 38.01 C \\\\nATOM 1878 C ASN A 238 -51.364 22.056 -56.911 1.00 38.01 C \\\\nATOM 1879 CB ASN A 238 -50.998 19.776 -57.931 1.00 38.01 C \\\\nATOM 1880 O ASN A 238 -52.565 22.311 -56.914 1.00 38.01 O \\\\nATOM 1881 CG ASN A 238 -49.783 19.919 -58.827 1.00 38.01 C \\\\nATOM 1882 ND2 ASN A 238 -49.811 19.335 -60.006 1.00 38.01 N \\\\nATOM 1883 OD1 ASN A 238 -48.781 20.517 -58.487 1.00 38.01 O \\\\nATOM 1884 N GLN A 239 -50.420 22.937 -57.292 1.00 40.11 N \\\\nATOM 1885 CA GLN A 239 -50.619 24.237 -58.001 1.00 40.11 C \\\\nATOM 1886 C GLN A 239 -51.303 25.383 -57.200 1.00 40.11 C \\\\nATOM 1887 CB GLN A 239 -51.318 23.941 -59.348 1.00 40.11 C \\\\nATOM 1888 O GLN A 239 -52.139 25.132 -56.350 1.00 40.11 O \\\\nATOM 1889 CG GLN A 239 -50.440 23.130 -60.314 1.00 40.11 C \\\\nATOM 1890 CD GLN A 239 -51.238 22.565 -61.483 1.00 40.11 C \\\\nATOM 1891 NE2 GLN A 239 -51.226 21.271 -61.713 1.00 40.11 N \\\\nATOM 1892 OE1 GLN A 239 -51.873 23.269 -62.241 1.00 40.11 O \\\\nATOM 1893 N SER A 240 -51.038 26.686 -57.365 1.00 43.35 N \\\\nATOM 1894 CA SER A 240 -50.202 27.499 -58.269 1.00 43.35 C \\\\nATOM 1895 C SER A 240 -50.144 28.959 -57.738 1.00 43.35 C \\\\nATOM 1896 CB SER A 240 -50.762 27.509 -59.706 1.00 43.35 C \\\\nATOM 1897 O SER A 240 -50.901 29.325 -56.844 1.00 43.35 O \\\\nATOM 1898 OG SER A 240 -52.158 27.305 -59.748 1.00 43.35 O \\\\nATOM 1899 N MET A 241 -49.217 29.754 -58.286 1.00 42.24 N \\\\nATOM 1900 CA MET A 241 -48.848 31.152 -57.975 1.00 42.24 C \\\\nATOM 1901 C MET A 241 -49.996 32.180 -58.075 1.00 42.24 C \\\\nATOM 1902 CB MET A 241 -47.796 31.564 -59.029 1.00 42.24 C \\\\nATOM 1903 O MET A 241 -50.863 32.002 -58.918 1.00 42.24 O \\\\nATOM 1904 CG MET A 241 -46.510 30.723 -59.019 1.00 42.24 C \\\\nATOM 1905 SD MET A 241 -45.467 30.947 -60.489 1.00 42.24 S \\\\nATOM 1906 CE MET A 241 -44.030 29.949 -60.015 1.00 42.24 C \\\\nATOM 1907 N ASP A 242 -49.936 33.283 -57.305 1.00 40.97 N \\\\nATOM 1908 CA ASP A 242 -49.971 34.649 -57.871 1.00 40.97 C \\\\nATOM 1909 C ASP A 242 -49.706 35.794 -56.863 1.00 40.97 C \\\\nATOM 1910 CB ASP A 242 -51.237 34.953 -58.711 1.00 40.97 C \\\\nATOM 1911 O ASP A 242 -49.965 35.727 -55.664 1.00 40.97 O \\\\nATOM 1912 CG ASP A 242 -51.029 34.730 -60.222 1.00 40.97 C \\\\nATOM 1913 OD1 ASP A 242 -49.864 34.851 -60.676 1.00 40.97 O \\\\nATOM 1914 OD2 ASP A 242 -52.042 34.530 -60.928 1.00 40.97 O \\\\nATOM 1915 N THR A 243 -49.128 36.839 -57.450 1.00 38.70 N \\\\nATOM 1916 CA THR A 243 -48.641 38.169 -57.038 1.00 38.70 C \\\\nATOM 1917 C THR A 243 -49.545 39.095 -56.201 1.00 38.70 C \\\\nATOM 1918 CB THR A 243 -48.421 38.931 -58.366 1.00 38.70 C \\\\nATOM 1919 O THR A 243 -50.746 39.164 -56.437 1.00 38.70 O \\\\nATOM 1920 CG2 THR A 243 -47.054 38.660 -58.985 1.00 38.70 C \\\\nATOM 1921 OG1 THR A 243 -49.362 38.545 -59.348 1.00 38.70 O \\\\nATOM 1922 N GLY A 244 -48.926 39.973 -55.383 1.00 39.50 N \\\\nATOM 1923 CA GLY A 244 -49.496 41.283 -54.995 1.00 39.50 C \\\\nATOM 1924 C GLY A 244 -49.025 41.882 -53.651 1.00 39.50 C \\\\nATOM 1925 O GLY A 244 -49.585 41.568 -52.609 1.00 39.50 O \\\\nATOM 1926 N SER A 245 -48.027 42.774 -53.675 1.00 42.65 N \\\\nATOM 1927 CA SER A 245 -47.559 43.641 -52.560 1.00 42.65 C \\\\nATOM 1928 C SER A 245 -48.484 44.872 -52.339 1.00 42.65 C \\\\nATOM 1929 CB SER A 245 -46.157 44.149 -52.950 1.00 42.65 C \\\\nATOM 1930 O SER A 245 -49.369 45.087 -53.164 1.00 42.65 O \\\\nATOM 1931 OG SER A 245 -45.287 43.109 -53.350 1.00 42.65 O \\\\nATOM 1932 N PRO A 246 -48.160 45.856 -51.462 1.00 43.21 N \\\\nATOM 1933 CA PRO A 246 -47.896 45.842 -50.010 1.00 43.21 C \\\\nATOM 1934 C PRO A 246 -48.722 46.921 -49.241 1.00 43.21 C \\\\nATOM 1935 CB PRO A 246 -46.411 46.213 -49.915 1.00 43.21 C \\\\nATOM 1936 O PRO A 246 -49.145 47.911 -49.832 1.00 43.21 O \\\\nATOM 1937 CG PRO A 246 -46.212 47.195 -51.082 1.00 43.21 C \\\\nATOM 1938 CD PRO A 246 -47.416 46.984 -52.009 1.00 43.21 C \\\\nATOM 1939 N ALA A 247 -48.870 46.811 -47.911 1.00 43.57 N \\\\nATOM 1940 CA ALA A 247 -49.324 47.925 -47.059 1.00 43.57 C \\\\nATOM 1941 C ALA A 247 -48.847 47.812 -45.588 1.00 43.57 C \\\\nATOM 1942 CB ALA A 247 -50.855 48.047 -47.127 1.00 43.57 C \\\\nATOM 1943 O ALA A 247 -49.112 46.824 -44.914 1.00 43.57 O \\\\nATOM 1944 N GLU A 248 -48.155 48.869 -45.145 1.00 39.39 N \\\\nATOM 1945 CA GLU A 248 -48.252 49.554 -43.837 1.00 39.39 C \\\\nATOM 1946 C GLU A 248 -47.778 48.893 -42.512 1.00 39.39 C \\\\nATOM 1947 CB GLU A 248 -49.618 50.255 -43.728 1.00 39.39 C \\\\nATOM 1948 O GLU A 248 -48.478 48.144 -41.844 1.00 39.39 O \\\\nATOM 1949 CG GLU A 248 -49.804 51.247 -44.896 1.00 39.39 C \\\\nATOM 1950 CD GLU A 248 -51.023 52.160 -44.732 1.00 39.39 C \\\\nATOM 1951 OE1 GLU A 248 -50.856 53.370 -45.004 1.00 39.39 O \\\\nATOM 1952 OE2 GLU A 248 -52.101 51.647 -44.362 1.00 39.39 O \\\\nATOM 1953 N LEU A 249 -46.569 49.313 -42.100 1.00 41.33 N \\\\nATOM 1954 CA LEU A 249 -46.170 49.896 -40.798 1.00 41.33 C \\\\nATOM 1955 C LEU A 249 -46.823 49.398 -39.486 1.00 41.33 C \\\\nATOM 1956 CB LEU A 249 -46.370 51.429 -40.891 1.00 41.33 C \\\\nATOM 1957 O LEU A 249 -47.955 49.752 -39.176 1.00 41.33 O \\\\nATOM 1958 CG LEU A 249 -45.467 52.162 -41.899 1.00 41.33 C \\\\nATOM 1959 CD1 LEU A 249 -46.013 53.561 -42.181 1.00 41.33 C \\\\nATOM 1960 CD2 LEU A 249 -44.037 52.303 -41.372 1.00 41.33 C \\\\nATOM 1961 N SER A 250 -46.004 48.805 -38.602 1.00 40.23 N \\\\nATOM 1962 CA SER A 250 -45.986 49.060 -37.140 1.00 40.23 C \\\\nATOM 1963 C SER A 250 -44.722 48.453 -36.493 1.00 40.23 C \\\\nATOM 1964 CB SER A 250 -47.207 48.455 -36.435 1.00 40.23 C \\\\nATOM 1965 O SER A 250 -44.469 47.267 -36.697 1.00 40.23 O \\\\nATOM 1966 OG SER A 250 -48.333 49.282 -36.627 1.00 40.23 O \\\\nATOM 1967 N PRO A 251 -43.913 49.201 -35.712 1.00 37.55 N \\\\nATOM 1968 CA PRO A 251 -42.774 48.652 -34.979 1.00 37.55 C \\\\nATOM 1969 C PRO A 251 -43.180 48.301 -33.541 1.00 37.55 C \\\\nATOM 1970 CB PRO A 251 -41.722 49.764 -35.026 1.00 37.55 C \\\\nATOM 1971 O PRO A 251 -43.771 49.122 -32.841 1.00 37.55 O \\\\nATOM 1972 CG PRO A 251 -42.560 51.046 -34.979 1.00 37.55 C \\\\nATOM 1973 CD PRO A 251 -43.921 50.653 -35.571 1.00 37.55 C \\\\nATOM 1974 N THR A 252 -42.853 47.104 -33.053 1.00 40.99 N \\\\nATOM 1975 CA THR A 252 -42.973 46.801 -31.617 1.00 40.99 C \\\\nATOM 1976 C THR A 252 -41.962 45.744 -31.171 1.00 40.99 C \\\\nATOM 1977 CB THR A 252 -44.410 46.432 -31.164 1.00 40.99 C \\\\nATOM 1978 O THR A 252 -42.014 44.586 -31.566 1.00 40.99 O \\\\nATOM 1979 CG2 THR A 252 -44.923 47.403 -30.096 1.00 40.99 C \\\\nATOM 1980 OG1 THR A 252 -45.352 46.526 -32.205 1.00 40.99 O \\\\nATOM 1981 N THR A 253 -41.062 46.204 -30.295 1.00 40.72 N \\\\nATOM 1982 CA THR A 253 -40.430 45.482 -29.175 1.00 40.72 C \\\\nATOM 1983 C THR A 253 -39.524 44.280 -29.471 1.00 40.72 C \\\\nATOM 1984 CB THR A 253 -41.461 45.163 -28.079 1.00 40.72 C \\\\nATOM 1985 O THR A 253 -39.961 43.140 -29.593 1.00 40.72 O \\\\nATOM 1986 CG2 THR A 253 -41.946 46.453 -27.410 1.00 40.72 C \\\\nATOM 1987 OG1 THR A 253 -42.597 44.519 -28.600 1.00 40.72 O \\\\nATOM 1988 N LEU A 254 -38.216 44.561 -29.424 1.00 39.36 N \\\\nATOM 1989 CA LEU A 254 -37.133 43.610 -29.166 1.00 39.36 C \\\\nATOM 1990 C LEU A 254 -37.409 42.817 -27.876 1.00 39.36 C \\\\nATOM 1991 CB LEU A 254 -35.824 44.415 -29.003 1.00 39.36 C \\\\nATOM 1992 O LEU A 254 -37.460 43.395 -26.791 1.00 39.36 O \\\\nATOM 1993 CG LEU A 254 -35.280 45.017 -30.315 1.00 39.36 C \\\\nATOM 1994 CD1 LEU A 254 -34.831 46.466 -30.117 1.00 39.36 C \\\\nATOM 1995 CD2 LEU A 254 -34.086 44.210 -30.824 1.00 39.36 C \\\\nATOM 1996 N SER A 255 -37.551 41.499 -28.001 1.00 41.25 N \\\\nATOM 1997 CA SER A 255 -37.453 40.555 -26.882 1.00 41.25 C \\\\nATOM 1998 C SER A 255 -36.006 40.052 -26.797 1.00 41.25 C \\\\nATOM 1999 CB SER A 255 -38.413 39.381 -27.082 1.00 41.25 C \\\\nATOM 2000 O SER A 255 -35.414 39.783 -27.845 1.00 41.25 O \\\\nATOM 2001 OG SER A 255 -39.740 39.860 -27.175 1.00 41.25 O \\\\nATOM 2002 N PRO A 256 -35.403 39.934 -25.602 1.00 41.93 N \\\\nATOM 2003 CA PRO A 256 -34.027 39.477 -25.476 1.00 41.93 C \\\\nATOM 2004 C PRO A 256 -33.949 37.988 -25.824 1.00 41.93 C \\\\nATOM 2005 CB PRO A 256 -33.620 39.791 -24.034 1.00 41.93 C \\\\nATOM 2006 O PRO A 256 -34.719 37.173 -25.314 1.00 41.93 O \\\\nATOM 2007 CG PRO A 256 -34.942 39.739 -23.267 1.00 41.93 C \\\\nATOM 2008 CD PRO A 256 -35.998 40.152 -24.294 1.00 41.93 C \\\\nATOM 2009 N VAL A 257 -33.012 37.640 -26.704 1.00 38.71 N \\\\nATOM 2010 CA VAL A 257 -32.677 36.258 -27.054 1.00 38.71 C \\\\nATOM 2011 C VAL A 257 -32.097 35.594 -25.803 1.00 38.71 C \\\\nATOM 2012 CB VAL A 257 -31.690 36.217 -28.246 1.00 38.71 C \\\\nATOM 2013 O VAL A 257 -30.939 35.808 -25.450 1.00 38.71 O \\\\nATOM 2014 CG1 VAL A 257 -31.494 34.785 -28.757 1.00 38.71 C \\\\nATOM 2015 CG2 VAL A 257 -32.192 37.068 -29.424 1.00 38.71 C \\\\nATOM 2016 N ASN A 258 -32.916 34.816 -25.092 1.00 38.20 N \\\\nATOM 2017 CA ASN A 258 -32.433 33.894 -24.070 1.00 38.20 C \\\\nATOM 2018 C ASN A 258 -31.664 32.778 -24.786 1.00 38.20 C \\\\nATOM 2019 CB ASN A 258 -33.611 33.347 -23.225 1.00 38.20 C \\\\nATOM 2020 O ASN A 258 -32.248 31.774 -25.190 1.00 38.20 O \\\\nATOM 2021 CG ASN A 258 -33.801 34.022 -21.876 1.00 38.20 C \\\\nATOM 2022 ND2 ASN A 258 -34.835 33.652 -21.157 1.00 38.20 N \\\\nATOM 2023 OD1 ASN A 258 -33.028 34.845 -21.420 1.00 38.20 O \\\\nATOM 2024 N HIS A 259 -30.350 32.941 -24.936 1.00 43.97 N \\\\nATOM 2025 CA HIS A 259 -29.453 31.814 -25.172 1.00 43.97 C \\\\nATOM 2026 C HIS A 259 -29.431 30.956 -23.899 1.00 43.97 C \\\\nATOM 2027 CB HIS A 259 -28.052 32.306 -25.574 1.00 43.97 C \\\\nATOM 2028 O HIS A 259 -28.532 31.072 -23.068 1.00 43.97 O \\\\nATOM 2029 CG HIS A 259 -27.983 32.894 -26.961 1.00 43.97 C \\\\nATOM 2030 CD2 HIS A 259 -27.892 34.221 -27.283 1.00 43.97 C \\\\nATOM 2031 ND1 HIS A 259 -27.951 32.189 -28.145 1.00 43.97 N \\\\nATOM 2032 CE1 HIS A 259 -27.839 33.070 -29.153 1.00 43.97 C \\\\nATOM 2033 NE2 HIS A 259 -27.810 34.324 -28.674 1.00 43.97 N \\\\nATOM 2034 N SER A 260 -30.452 30.116 -23.702 1.00 46.85 N \\\\nATOM 2035 CA SER A 260 -30.347 29.020 -22.745 1.00 46.85 C \\\\nATOM 2036 C SER A 260 -29.341 28.033 -23.325 1.00 46.85 C \\\\nATOM 2037 CB SER A 260 -31.703 28.365 -22.442 1.00 46.85 C \\\\nATOM 2038 O SER A 260 -29.677 27.256 -24.218 1.00 46.85 O \\\\nATOM 2039 OG SER A 260 -32.255 27.717 -23.567 1.00 46.85 O \\\\nATOM 2040 N LEU A 261 -28.090 28.107 -22.870 1.00 57.93 N \\\\nATOM 2041 CA LEU A 261 -27.111 27.052 -23.102 1.00 57.93 C \\\\nATOM 2042 C LEU A 261 -27.748 25.739 -22.633 1.00 57.93 C \\\\nATOM 2043 CB LEU A 261 -25.818 27.369 -22.324 1.00 57.93 C \\\\nATOM 2044 O LEU A 261 -28.035 25.584 -21.445 1.00 57.93 O \\\\nATOM 2045 CG LEU A 261 -25.012 28.555 -22.887 1.00 57.93 C \\\\nATOM 2046 CD1 LEU A 261 -23.962 29.004 -21.869 1.00 57.93 C \\\\nATOM 2047 CD2 LEU A 261 -24.291 28.181 -24.185 1.00 57.93 C \\\\nATOM 2048 N ASP A 262 -28.031 24.838 -23.573 1.00 70.10 N \\\\nATOM 2049 CA ASP A 262 -28.588 23.519 -23.283 1.00 70.10 C \\\\nATOM 2050 C ASP A 262 -27.473 22.683 -22.635 1.00 70.10 C \\\\nATOM 2051 CB ASP A 262 -29.195 22.914 -24.566 1.00 70.10 C \\\\nATOM 2052 O ASP A 262 -26.625 22.085 -23.302 1.00 70.10 O \\\\nATOM 2053 CG ASP A 262 -30.120 21.714 -24.313 1.00 70.10 C \\\\nATOM 2054 OD1 ASP A 262 -30.649 21.595 -23.187 1.00 70.10 O \\\\nATOM 2055 OD2 ASP A 262 -30.301 20.904 -25.257 1.00 70.10 O \\\\nATOM 2056 N LEU A 263 -27.388 22.779 -21.307 1.00 79.04 N \\\\nATOM 2057 CA LEU A 263 -26.398 22.100 -20.479 1.00 79.04 C \\\\nATOM 2058 C LEU A 263 -26.907 20.697 -20.144 1.00 79.04 C \\\\nATOM 2059 CB LEU A 263 -26.142 22.921 -19.199 1.00 79.04 C \\\\nATOM 2060 O LEU A 263 -27.904 20.543 -19.438 1.00 79.04 O \\\\nATOM 2061 CG LEU A 263 -25.343 24.222 -19.402 1.00 79.04 C \\\\nATOM 2062 CD1 LEU A 263 -25.410 25.078 -18.136 1.00 79.04 C \\\\nATOM 2063 CD2 LEU A 263 -23.866 23.953 -19.694 1.00 79.04 C \\\\nATOM 2064 N GLN A 264 -26.191 19.668 -20.593 1.00 82.84 N \\\\nATOM 2065 CA GLN A 264 -26.520 18.281 -20.275 1.00 82.84 C \\\\nATOM 2066 C GLN A 264 -25.827 17.858 -18.964 1.00 82.84 C \\\\nATOM 2067 CB GLN A 264 -26.128 17.375 -21.451 1.00 82.84 C \\\\nATOM 2068 O GLN A 264 -24.595 17.875 -18.900 1.00 82.84 O \\\\nATOM 2069 CG GLN A 264 -26.586 15.919 -21.255 1.00 82.84 C \\\\nATOM 2070 CD GLN A 264 -28.099 15.731 -21.323 1.00 82.84 C \\\\nATOM 2071 NE2 GLN A 264 -28.653 14.767 -20.625 1.00 82.84 N \\\\nATOM 2072 OE1 GLN A 264 -28.816 16.404 -22.041 1.00 82.84 O \\\\nATOM 2073 N PRO A 265 -26.566 17.436 -17.920 1.00 88.13 N \\\\nATOM 2074 CA PRO A 265 -25.963 16.916 -16.697 1.00 88.13 C \\\\nATOM 2075 C PRO A 265 -25.456 15.478 -16.887 1.00 88.13 C \\\\nATOM 2076 CB PRO A 265 -27.061 17.016 -15.634 1.00 88.13 C \\\\nATOM 2077 O PRO A 265 -26.204 14.589 -17.296 1.00 88.13 O \\\\nATOM 2078 CG PRO A 265 -28.351 16.862 -16.442 1.00 88.13 C \\\\nATOM 2079 CD PRO A 265 -28.015 17.515 -17.783 1.00 88.13 C \\\\nATOM 2080 N VAL A 266 -24.196 15.235 -16.522 1.00 88.49 N \\\\nATOM 2081 CA VAL A 266 -23.542 13.920 -16.544 1.00 88.49 C \\\\nATOM 2082 C VAL A 266 -23.222 13.471 -15.117 1.00 88.49 C \\\\nATOM 2083 CB VAL A 266 -22.277 13.943 -17.424 1.00 88.49 C \\\\nATOM 2084 O VAL A 266 -22.374 14.053 -14.434 1.00 88.49 O \\\\nATOM 2085 CG1 VAL A 266 -21.631 12.554 -17.454 1.00 88.49 C \\\\nATOM 2086 CG2 VAL A 266 -22.603 14.340 -18.870 1.00 88.49 C \\\\nATOM 2087 N THR A 267 -23.899 12.416 -14.658 1.00 89.40 N \\\\nATOM 2088 CA THR A 267 -23.777 11.883 -13.292 1.00 89.40 C \\\\nATOM 2089 C THR A 267 -22.712 10.789 -13.167 1.00 89.40 C \\\\nATOM 2090 CB THR A 267 -25.125 11.358 -12.769 1.00 89.40 C \\\\nATOM 2091 O THR A 267 -22.523 9.952 -14.059 1.00 89.40 O \\\\nATOM 2092 CG2 THR A 267 -26.161 12.469 -12.601 1.00 89.40 C \\\\nATOM 2093 OG1 THR A 267 -25.678 10.415 -13.657 1.00 89.40 O \\\\nATOM 2094 N TYR A 268 -22.040 10.769 -12.013 1.00 89.45 N \\\\nATOM 2095 CA TYR A 268 -21.136 9.689 -11.622 1.00 89.45 C \\\\nATOM 2096 C TYR A 268 -21.918 8.409 -11.295 1.00 89.45 C \\\\nATOM 2097 CB TYR A 268 -20.292 10.126 -10.418 1.00 89.45 C \\\\nATOM 2098 O TYR A 268 -22.978 8.457 -10.670 1.00 89.45 O \\\\nATOM 2099 CG TYR A 268 -19.250 9.105 -9.993 1.00 89.45 C \\\\nATOM 2100 CD1 TYR A 268 -19.514 8.182 -8.961 1.00 89.45 C \\\\nATOM 2101 CD2 TYR A 268 -18.001 9.084 -10.631 1.00 89.45 C \\\\nATOM 2102 CE1 TYR A 268 -18.526 7.253 -8.569 1.00 89.45 C \\\\nATOM 2103 CE2 TYR A 268 -17.000 8.186 -10.220 1.00 89.45 C \\\\nATOM 2104 OH TYR A 268 -16.280 6.389 -8.811 1.00 89.45 O \\\\nATOM 2105 CZ TYR A 268 -17.259 7.256 -9.192 1.00 89.45 C \\\\nATOM 2106 N SER A 269 -21.368 7.259 -11.680 1.00 85.81 N \\\\nATOM 2107 CA SER A 269 -21.863 5.937 -11.292 1.00 85.81 C \\\\nATOM 2108 C SER A 269 -20.695 5.073 -10.841 1.00 85.81 C \\\\nATOM 2109 CB SER A 269 -22.624 5.259 -12.439 1.00 85.81 C \\\\nATOM 2110 O SER A 269 -19.671 5.038 -11.516 1.00 85.81 O \\\\nATOM 2111 OG SER A 269 -21.890 5.242 -13.658 1.00 85.81 O \\\\nATOM 2112 N GLU A 270 -20.845 4.374 -9.718 1.00 86.25 N \\\\nATOM 2113 CA GLU A 270 -19.789 3.501 -9.206 1.00 86.25 C \\\\nATOM 2114 C GLU A 270 -19.738 2.192 -10.023 1.00 86.25 C \\\\nATOM 2115 CB GLU A 270 -20.010 3.232 -7.709 1.00 86.25 C \\\\nATOM 2116 O GLU A 270 -20.766 1.516 -10.152 1.00 86.25 O \\\\nATOM 2117 CG GLU A 270 -18.728 2.796 -6.984 1.00 86.25 C \\\\nATOM 2118 CD GLU A 270 -17.764 3.974 -6.775 1.00 86.25 C \\\\nATOM 2119 OE1 GLU A 270 -16.707 4.031 -7.432 1.00 86.25 O \\\\nATOM 2120 OE2 GLU A 270 -18.057 4.870 -5.955 1.00 86.25 O \\\\nATOM 2121 N PRO A 271 -18.581 1.815 -10.592 1.00 91.14 N \\\\nATOM 2122 CA PRO A 271 -18.441 0.578 -11.353 1.00 91.14 C \\\\nATOM 2123 C PRO A 271 -18.353 -0.655 -10.440 1.00 91.14 C \\\\nATOM 2124 CB PRO A 271 -17.169 0.768 -12.180 1.00 91.14 C \\\\nATOM 2125 O PRO A 271 -17.957 -0.569 -9.280 1.00 91.14 O \\\\nATOM 2126 CG PRO A 271 -16.321 1.650 -11.272 1.00 91.14 C \\\\nATOM 2127 CD PRO A 271 -17.340 2.574 -10.621 1.00 91.14 C \\\\nATOM 2128 N ALA A 272 -18.644 -1.837 -10.995 1.00 89.84 N \\\\nATOM 2129 CA ALA A 272 -18.530 -3.114 -10.275 1.00 89.84 C \\\\nATOM 2130 C ALA A 272 -17.092 -3.431 -9.816 1.00 89.84 C \\\\nATOM 2131 CB ALA A 272 -19.057 -4.227 -11.189 1.00 89.84 C \\\\nATOM 2132 O ALA A 272 -16.889 -4.063 -8.781 1.00 89.84 O \\\\nATOM 2133 N PHE A 273 -16.099 -2.982 -10.588 1.00 94.27 N \\\\nATOM 2134 CA PHE A 273 -14.688 -3.017 -10.220 1.00 94.27 C \\\\nATOM 2135 C PHE A 273 -14.194 -1.585 -10.114 1.00 94.27 C \\\\nATOM 2136 CB PHE A 273 -13.874 -3.797 -11.260 1.00 94.27 C \\\\nATOM 2137 O PHE A 273 -14.209 -0.868 -11.114 1.00 94.27 O \\\\nATOM 2138 CG PHE A 273 -14.326 -5.227 -11.449 1.00 94.27 C \\\\nATOM 2139 CD1 PHE A 273 -13.887 -6.225 -10.564 1.00 94.27 C \\\\nATOM 2140 CD2 PHE A 273 -15.184 -5.565 -12.512 1.00 94.27 C \\\\nATOM 2141 CE1 PHE A 273 -14.299 -7.557 -10.732 1.00 94.27 C \\\\nATOM 2142 CE2 PHE A 273 -15.603 -6.897 -12.679 1.00 94.27 C \\\\nATOM 2143 CZ PHE A 273 -15.162 -7.892 -11.790 1.00 94.27 C \\\\nATOM 2144 N TRP A 274 -13.742 -1.160 -8.939 1.00 95.07 N \\\\nATOM 2145 CA TRP A 274 -13.333 0.229 -8.720 1.00 95.07 C \\\\nATOM 2146 C TRP A 274 -11.968 0.541 -9.349 1.00 95.07 C \\\\nATOM 2147 CB TRP A 274 -13.369 0.531 -7.223 1.00 95.07 C \\\\nATOM 2148 O TRP A 274 -11.717 1.679 -9.749 1.00 95.07 O \\\\nATOM 2149 CG TRP A 274 -12.348 -0.198 -6.411 1.00 95.07 C \\\\nATOM 2150 CD1 TRP A 274 -12.518 -1.390 -5.799 1.00 95.07 C \\\\nATOM 2151 CD2 TRP A 274 -10.987 0.221 -6.105 1.00 95.07 C \\\\nATOM 2152 CE2 TRP A 274 -10.390 -0.761 -5.262 1.00 95.07 C \\\\nATOM 2153 CE3 TRP A 274 -10.209 1.350 -6.438 1.00 95.07 C \\\\nATOM 2154 NE1 TRP A 274 -11.364 -1.725 -5.122 1.00 95.07 N \\\\nATOM 2155 CH2 TRP A 274 -8.338 0.512 -5.116 1.00 95.07 C \\\\nATOM 2156 CZ2 TRP A 274 -9.095 -0.612 -4.746 1.00 95.07 C \\\\nATOM 2157 CZ3 TRP A 274 -8.892 1.487 -5.963 1.00 95.07 C \\\\nATOM 2158 N CYS A 275 -11.102 -0.468 -9.505 1.00 97.41 N \\\\nATOM 2159 CA CYS A 275 -9.862 -0.335 -10.263 1.00 97.41 C \\\\nATOM 2160 C CYS A 275 -9.446 -1.606 -11.010 1.00 97.41 C \\\\nATOM 2161 CB CYS A 275 -8.727 0.177 -9.357 1.00 97.41 C \\\\nATOM 2162 O CYS A 275 -9.892 -2.718 -10.710 1.00 97.41 O \\\\nATOM 2163 SG CYS A 275 -8.172 -1.078 -8.170 1.00 97.41 S \\\\nATOM 2164 N SER A 276 -8.544 -1.421 -11.972 1.00 97.86 N \\\\nATOM 2165 CA SER A 276 -7.793 -2.494 -12.626 1.00 97.86 C \\\\nATOM 2166 C SER A 276 -6.289 -2.268 -12.470 1.00 97.86 C \\\\nATOM 2167 CB SER A 276 -8.208 -2.627 -14.092 1.00 97.86 C \\\\nATOM 2168 O SER A 276 -5.836 -1.124 -12.540 1.00 97.86 O \\\\nATOM 2169 OG SER A 276 -7.734 -1.550 -14.869 1.00 97.86 O \\\\nATOM 2170 N ILE A 277 -5.524 -3.339 -12.253 1.00 98.47 N \\\\nATOM 2171 CA ILE A 277 -4.088 -3.291 -11.952 1.00 98.47 C \\\\nATOM 2172 C ILE A 277 -3.315 -4.126 -12.969 1.00 98.47 C \\\\nATOM 2173 CB ILE A 277 -3.763 -3.772 -10.515 1.00 98.47 C \\\\nATOM 2174 O ILE A 277 -3.540 -5.331 -13.081 1.00 98.47 O \\\\nATOM 2175 CG1 ILE A 277 -4.882 -3.422 -9.506 1.00 98.47 C \\\\nATOM 2176 CG2 ILE A 277 -2.366 -3.251 -10.127 1.00 98.47 C \\\\nATOM 2177 CD1 ILE A 277 -4.496 -3.473 -8.027 1.00 98.47 C \\\\nATOM 2178 N ALA A 278 -2.370 -3.509 -13.673 1.00 98.55 N \\\\nATOM 2179 CA ALA A 278 -1.424 -4.200 -14.544 1.00 98.55 C \\\\nATOM 2180 C ALA A 278 -0.030 -4.218 -13.905 1.00 98.55 C \\\\nATOM 2181 CB ALA A 278 -1.436 -3.533 -15.922 1.00 98.55 C \\\\nATOM 2182 O ALA A 278 0.429 -3.200 -13.390 1.00 98.55 O \\\\nATOM 2183 N TYR A 279 0.645 -5.369 -13.934 1.00 98.63 N \\\\nATOM 2184 CA TYR A 279 2.011 -5.519 -13.431 1.00 98.63 C \\\\nATOM 2185 C TYR A 279 3.033 -5.476 -14.565 1.00 98.63 C \\\\nATOM 2186 CB TYR A 279 2.130 -6.801 -12.598 1.00 98.63 C \\\\nATOM 2187 O TYR A 279 2.824 -6.041 -15.641 1.00 98.63 O \\\\nATOM 2188 CG TYR A 279 3.542 -7.114 -12.125 1.00 98.63 C \\\\nATOM 2189 CD1 TYR A 279 4.171 -8.309 -12.518 1.00 98.63 C \\\\nATOM 2190 CD2 TYR A 279 4.229 -6.208 -11.296 1.00 98.63 C \\\\nATOM 2191 CE1 TYR A 279 5.469 -8.611 -12.068 1.00 98.63 C \\\\nATOM 2192 CE2 TYR A 279 5.536 -6.493 -10.858 1.00 98.63 C \\\\nATOM 2193 OH TYR A 279 7.386 -8.020 -10.749 1.00 98.63 O \\\\nATOM 2194 CZ TYR A 279 6.152 -7.707 -11.229 1.00 98.63 C \\\\nATOM 2195 N TYR A 280 4.157 -4.820 -14.295 1.00 98.73 N \\\\nATOM 2196 CA TYR A 280 5.253 -4.645 -15.227 1.00 98.73 C \\\\nATOM 2197 C TYR A 280 6.598 -4.950 -14.563 1.00 98.73 C \\\\nATOM 2198 CB TYR A 280 5.235 -3.217 -15.775 1.00 98.73 C \\\\nATOM 2199 O TYR A 280 6.865 -4.613 -13.403 1.00 98.73 O \\\\nATOM 2200 CG TYR A 280 4.056 -2.864 -16.663 1.00 98.73 C \\\\nATOM 2201 CD1 TYR A 280 4.181 -2.933 -18.064 1.00 98.73 C \\\\nATOM 2202 CD2 TYR A 280 2.855 -2.401 -16.090 1.00 98.73 C \\\\nATOM 2203 CE1 TYR A 280 3.098 -2.569 -18.890 1.00 98.73 C \\\\nATOM 2204 CE2 TYR A 280 1.780 -2.014 -16.913 1.00 98.73 C \\\\nATOM 2205 OH TYR A 280 0.868 -1.716 -19.113 1.00 98.73 O \\\\nATOM 2206 CZ TYR A 280 1.896 -2.105 -18.315 1.00 98.73 C \\\\nATOM 2207 N GLU A 281 7.479 -5.555 -15.351 1.00 98.51 N \\\\nATOM 2208 CA GLU A 281 8.898 -5.694 -15.056 1.00 98.51 C \\\\nATOM 2209 C GLU A 281 9.661 -4.903 -16.118 1.00 98.51 C \\\\nATOM 2210 CB GLU A 281 9.305 -7.179 -15.015 1.00 98.51 C \\\\nATOM 2211 O GLU A 281 9.632 -5.253 -17.297 1.00 98.51 O \\\\nATOM 2212 CG GLU A 281 8.652 -7.916 -13.832 1.00 98.51 C \\\\nATOM 2213 CD GLU A 281 8.992 -9.413 -13.731 1.00 98.51 C \\\\nATOM 2214 OE1 GLU A 281 8.462 -10.094 -12.822 1.00 98.51 O \\\\nATOM 2215 OE2 GLU A 281 9.816 -9.955 -14.502 1.00 98.51 O \\\\nATOM 2216 N LEU A 282 10.322 -3.812 -15.716 1.00 97.97 N \\\\nATOM 2217 CA LEU A 282 10.910 -2.843 -16.646 1.00 97.97 C \\\\nATOM 2218 C LEU A 282 9.847 -2.264 -17.600 1.00 97.97 C \\\\nATOM 2219 CB LEU A 282 12.144 -3.445 -17.358 1.00 97.97 C \\\\nATOM 2220 O LEU A 282 8.870 -1.684 -17.146 1.00 97.97 O \\\\nATOM 2221 CG LEU A 282 13.223 -3.999 -16.419 1.00 97.97 C \\\\nATOM 2222 CD1 LEU A 282 14.239 -4.800 -17.230 1.00 97.97 C \\\\nATOM 2223 CD2 LEU A 282 13.966 -2.879 -15.685 1.00 97.97 C \\\\nATOM 2224 N ASN A 283 10.004 -2.398 -18.913 1.00 97.02 N \\\\nATOM 2225 CA ASN A 283 9.026 -1.967 -19.914 1.00 97.02 C \\\\nATOM 2226 C ASN A 283 8.091 -3.098 -20.380 1.00 97.02 C \\\\nATOM 2227 CB ASN A 283 9.777 -1.319 -21.090 1.00 97.02 C \\\\nATOM 2228 O ASN A 283 7.291 -2.881 -21.287 1.00 97.02 O \\\\nATOM 2229 CG ASN A 283 10.673 -2.289 -21.843 1.00 97.02 C \\\\nATOM 2230 ND2 ASN A 283 10.969 -2.008 -23.087 1.00 97.02 N \\\\nATOM 2231 OD1 ASN A 283 11.151 -3.283 -21.320 1.00 97.02 O \\\\nATOM 2232 N GLN A 284 8.187 -4.297 -19.798 1.00 97.84 N \\\\nATOM 2233 CA GLN A 284 7.410 -5.460 -20.216 1.00 97.84 C \\\\nATOM 2234 C GLN A 284 6.244 -5.708 -19.260 1.00 97.84 C \\\\nATOM 2235 CB GLN A 284 8.342 -6.674 -20.321 1.00 97.84 C \\\\nATOM 2236 O GLN A 284 6.435 -5.811 -18.048 1.00 97.84 O \\\\nATOM 2237 CG GLN A 284 7.625 -7.885 -20.934 1.00 97.84 C \\\\nATOM 2238 CD GLN A 284 8.527 -9.101 -21.097 1.00 97.84 C \\\\nATOM 2239 NE2 GLN A 284 8.044 -10.153 -21.718 1.00 97.84 N \\\\nATOM 2240 OE1 GLN A 284 9.677 -9.143 -20.691 1.00 97.84 O \\\\nATOM 2241 N ARG A 285 5.033 -5.853 -19.806 1.00 98.04 N \\\\nATOM 2242 CA ARG A 285 3.860 -6.294 -19.041 1.00 98.04 C \\\\nATOM 2243 C ARG A 285 3.996 -7.771 -18.681 1.00 98.04 C \\\\nATOM 2244 CB ARG A 285 2.586 -6.010 -19.841 1.00 98.04 C \\\\nATOM 2245 O ARG A 285 4.353 -8.586 -19.531 1.00 98.04 O \\\\nATOM 2246 CG ARG A 285 1.316 -6.279 -19.020 1.00 98.04 C \\\\nATOM 2247 CD ARG A 285 0.115 -5.771 -19.815 1.00 98.04 C \\\\nATOM 2248 NE ARG A 285 -1.167 -6.187 -19.224 1.00 98.04 N \\\\nATOM 2249 NH1 ARG A 285 -2.464 -5.493 -20.990 1.00 98.04 N \\\\nATOM 2250 NH2 ARG A 285 -3.411 -6.566 -19.315 1.00 98.04 N \\\\nATOM 2251 CZ ARG A 285 -2.332 -6.079 -19.834 1.00 98.04 C \\\\nATOM 2252 N VAL A 286 3.700 -8.113 -17.432 1.00 98.24 N \\\\nATOM 2253 CA VAL A 286 3.852 -9.466 -16.892 1.00 98.24 C \\\\nATOM 2254 C VAL A 286 2.558 -9.890 -16.201 1.00 98.24 C \\\\nATOM 2255 CB VAL A 286 5.064 -9.534 -15.940 1.00 98.24 C \\\\nATOM 2256 O VAL A 286 2.137 -9.270 -15.229 1.00 98.24 O \\\\nATOM 2257 CG1 VAL A 286 5.211 -10.922 -15.307 1.00 98.24 C \\\\nATOM 2258 CG2 VAL A 286 6.374 -9.224 -16.675 1.00 98.24 C \\\\nATOM 2259 N GLY A 287 1.964 -10.987 -16.673 1.00 96.53 N \\\\nATOM 2260 CA GLY A 287 0.712 -11.524 -16.137 1.00 96.53 C \\\\nATOM 2261 C GLY A 287 -0.550 -10.832 -16.658 1.00 96.53 C \\\\nATOM 2262 O GLY A 287 -0.506 -9.941 -17.509 1.00 96.53 O \\\\nATOM 2263 N GLU A 288 -1.691 -11.282 -16.143 1.00 95.82 N \\\\nATOM 2264 CA GLU A 288 -3.015 -10.746 -16.466 1.00 95.82 C \\\\nATOM 2265 C GLU A 288 -3.318 -9.466 -15.673 1.00 95.82 C \\\\nATOM 2266 CB GLU A 288 -4.087 -11.816 -16.208 1.00 95.82 C \\\\nATOM 2267 O GLU A 288 -2.705 -9.190 -14.639 1.00 95.82 O \\\\nATOM 2268 CG GLU A 288 -3.880 -13.061 -17.087 1.00 95.82 C \\\\nATOM 2269 CD GLU A 288 -4.966 -14.124 -16.878 1.00 95.82 C \\\\nATOM 2270 OE1 GLU A 288 -5.203 -14.883 -17.841 1.00 95.82 O \\\\nATOM 2271 OE2 GLU A 288 -5.517 -14.185 -15.757 1.00 95.82 O \\\\nATOM 2272 N THR A 289 -4.281 -8.673 -16.151 1.00 97.10 N \\\\nATOM 2273 CA THR A 289 -4.793 -7.538 -15.371 1.00 97.10 C \\\\nATOM 2274 C THR A 289 -5.664 -8.040 -14.233 1.00 97.10 C \\\\nATOM 2275 CB THR A 289 -5.594 -6.550 -16.222 1.00 97.10 C \\\\nATOM 2276 O THR A 289 -6.643 -8.753 -14.450 1.00 97.10 O \\\\nATOM 2277 CG2 THR A 289 -6.231 -5.405 -15.443 1.00 97.10 C \\\\nATOM 2278 OG1 THR A 289 -4.718 -5.889 -17.089 1.00 97.10 O \\\\nATOM 2279 N PHE A 290 -5.354 -7.596 -13.022 1.00 96.97 N \\\\nATOM 2280 CA PHE A 290 -6.176 -7.846 -11.851 1.00 96.97 C \\\\nATOM 2281 C PHE A 290 -7.320 -6.830 -11.776 1.00 96.97 C \\\\nATOM 2282 CB PHE A 290 -5.278 -7.792 -10.620 1.00 96.97 C \\\\nATOM 2283 O PHE A 290 -7.086 -5.631 -11.914 1.00 96.97 O \\\\nATOM 2284 CG PHE A 290 -5.994 -8.160 -9.344 1.00 96.97 C \\\\nATOM 2285 CD1 PHE A 290 -6.638 -7.167 -8.583 1.00 96.97 C \\\\nATOM 2286 CD2 PHE A 290 -6.019 -9.502 -8.923 1.00 96.97 C \\\\nATOM 2287 CE1 PHE A 290 -7.286 -7.513 -7.387 1.00 96.97 C \\\\nATOM 2288 CE2 PHE A 290 -6.657 -9.847 -7.721 1.00 96.97 C \\\\nATOM 2289 CZ PHE A 290 -7.279 -8.850 -6.953 1.00 96.97 C \\\\nATOM 2290 N HIS A 291 -8.545 -7.287 -11.519 1.00 96.94 N \\\\nATOM 2291 CA HIS A 291 -9.725 -6.426 -11.405 1.00 96.94 C \\\\nATOM 2292 C HIS A 291 -10.249 -6.449 -9.969 1.00 96.94 C \\\\nATOM 2293 CB HIS A 291 -10.791 -6.861 -12.416 1.00 96.94 C \\\\nATOM 2294 O HIS A 291 -10.591 -7.504 -9.439 1.00 96.94 O \\\\nATOM 2295 CG HIS A 291 -10.338 -6.727 -13.848 1.00 96.94 C \\\\nATOM 2296 CD2 HIS A 291 -10.580 -5.670 -14.683 1.00 96.94 C \\\\nATOM 2297 ND1 HIS A 291 -9.591 -7.641 -14.559 1.00 96.94 N \\\\nATOM 2298 CE1 HIS A 291 -9.403 -7.152 -15.793 1.00 96.94 C \\\\nATOM 2299 NE2 HIS A 291 -9.971 -5.943 -15.910 1.00 96.94 N \\\\nATOM 2300 N ALA A 292 -10.304 -5.281 -9.332 1.00 94.85 N \\\\nATOM 2301 CA ALA A 292 -10.612 -5.160 -7.915 1.00 94.85 C \\\\nATOM 2302 C ALA A 292 -12.092 -4.856 -7.678 1.00 94.85 C \\\\nATOM 2303 CB ALA A 292 -9.737 -4.054 -7.345 1.00 94.85 C \\\\nATOM 2304 O ALA A 292 -12.557 -3.755 -7.970 1.00 94.85 O \\\\nATOM 2305 N SER A 293 -12.831 -5.824 -7.138 1.00 91.03 N \\\\nATOM 2306 CA SER A 293 -14.233 -5.637 -6.736 1.00 91.03 C \\\\nATOM 2307 C SER A 293 -14.364 -5.249 -5.264 1.00 91.03 C \\\\nATOM 2308 CB SER A 293 -15.029 -6.910 -7.021 1.00 91.03 C \\\\nATOM 2309 O SER A 293 -15.207 -4.432 -4.909 1.00 91.03 O \\\\nATOM 2310 OG SER A 293 -14.425 -8.035 -6.398 1.00 91.03 O \\\\nATOM 2311 N GLN A 294 -13.508 -5.801 -4.401 1.00 90.62 N \\\\nATOM 2312 CA GLN A 294 -13.521 -5.508 -2.970 1.00 90.62 C \\\\nATOM 2313 C GLN A 294 -12.933 -4.120 -2.681 1.00 90.62 C \\\\nATOM 2314 CB GLN A 294 -12.771 -6.602 -2.189 1.00 90.62 C \\\\nATOM 2315 O GLN A 294 -11.941 -3.742 -3.312 1.00 90.62 O \\\\nATOM 2316 CG GLN A 294 -13.435 -7.982 -2.320 1.00 90.62 C \\\\nATOM 2317 CD GLN A 294 -14.891 -7.991 -1.863 1.00 90.62 C \\\\nATOM 2318 NE2 GLN A 294 -15.742 -8.766 -2.496 1.00 90.62 N \\\\nATOM 2319 OE1 GLN A 294 -15.304 -7.279 -0.963 1.00 90.62 O \\\\nATOM 2320 N PRO A 295 -13.460 -3.378 -1.687 1.00 89.93 N \\\\nATOM 2321 CA PRO A 295 -12.981 -2.036 -1.345 1.00 89.93 C \\\\nATOM 2322 C PRO A 295 -11.551 -2.033 -0.797 1.00 89.93 C \\\\nATOM 2323 CB PRO A 295 -13.969 -1.515 -0.295 1.00 89.93 C \\\\nATOM 2324 O PRO A 295 -10.946 -0.978 -0.670 1.00 89.93 O \\\\nATOM 2325 CG PRO A 295 -14.477 -2.789 0.379 1.00 89.93 C \\\\nATOM 2326 CD PRO A 295 -14.529 -3.779 -0.780 1.00 89.93 C \\\\nATOM 2327 N SER A 296 -10.995 -3.195 -0.456 1.00 92.89 N \\\\nATOM 2328 CA SER A 296 -9.617 -3.358 -0.006 1.00 92.89 C \\\\nATOM 2329 C SER A 296 -8.981 -4.532 -0.741 1.00 92.89 C \\\\nATOM 2330 CB SER A 296 -9.600 -3.576 1.509 1.00 92.89 C \\\\nATOM 2331 O SER A 296 -9.544 -5.622 -0.763 1.00 92.89 O \\\\nATOM 2332 OG SER A 296 -8.313 -3.961 1.962 1.00 92.89 O \\\\nATOM 2333 N LEU A 297 -7.772 -4.335 -1.261 1.00 96.06 N \\\\nATOM 2334 CA LEU A 297 -6.951 -5.391 -1.853 1.00 96.06 C \\\\nATOM 2335 C LEU A 297 -5.479 -5.222 -1.463 1.00 96.06 C \\\\nATOM 2336 CB LEU A 297 -7.161 -5.421 -3.378 1.00 96.06 C \\\\nATOM 2337 O LEU A 297 -5.037 -4.141 -1.076 1.00 96.06 O \\\\nATOM 2338 CG LEU A 297 -6.436 -4.267 -4.101 1.00 96.06 C \\\\nATOM 2339 CD1 LEU A 297 -5.200 -4.773 -4.846 1.00 96.06 C \\\\nATOM 2340 CD2 LEU A 297 -7.335 -3.596 -5.117 1.00 96.06 C \\\\nATOM 2341 N THR A 298 -4.699 -6.290 -1.571 1.00 97.78 N \\\\nATOM 2342 CA THR A 298 -3.249 -6.266 -1.349 1.00 97.78 C \\\\nATOM 2343 C THR A 298 -2.525 -6.752 -2.597 1.00 97.78 C \\\\nATOM 2344 CB THR A 298 -2.871 -7.103 -0.118 1.00 97.78 C \\\\nATOM 2345 O THR A 298 -2.809 -7.838 -3.088 1.00 97.78 O \\\\nATOM 2346 CG2 THR A 298 -1.411 -6.913 0.276 1.00 97.78 C \\\\nATOM 2347 OG1 THR A 298 -3.663 -6.707 0.989 1.00 97.78 O \\\\nATOM 2348 N VAL A 299 -1.578 -5.969 -3.109 1.00 98.41 N \\\\nATOM 2349 CA VAL A 299 -0.645 -6.407 -4.154 1.00 98.41 C \\\\nATOM 2350 C VAL A 299 0.644 -6.826 -3.462 1.00 98.41 C \\\\nATOM 2351 CB VAL A 299 -0.384 -5.311 -5.202 1.00 98.41 C \\\\nATOM 2352 O VAL A 299 1.325 -5.978 -2.886 1.00 98.41 O \\\\nATOM 2353 CG1 VAL A 299 0.448 -5.885 -6.351 1.00 98.41 C \\\\nATOM 2354 CG2 VAL A 299 -1.672 -4.700 -5.766 1.00 98.41 C \\\\nATOM 2355 N ASP A 300 0.964 -8.118 -3.477 1.00 98.33 N \\\\nATOM 2356 CA ASP A 300 2.064 -8.694 -2.697 1.00 98.33 C \\\\nATOM 2357 C ASP A 300 2.994 -9.587 -3.532 1.00 98.33 C \\\\nATOM 2358 CB ASP A 300 1.516 -9.372 -1.427 1.00 98.33 C \\\\nATOM 2359 O ASP A 300 2.729 -9.896 -4.690 1.00 98.33 O \\\\nATOM 2360 CG ASP A 300 0.725 -10.659 -1.648 1.00 98.33 C \\\\nATOM 2361 OD1 ASP A 300 1.220 -11.561 -2.354 1.00 98.33 O \\\\nATOM 2362 OD2 ASP A 300 -0.292 -10.861 -0.942 1.00 98.33 O \\\\nATOM 2363 N GLY A 301 4.136 -9.963 -2.957 1.00 97.82 N \\\\nATOM 2364 CA GLY A 301 5.156 -10.794 -3.602 1.00 97.82 C \\\\nATOM 2365 C GLY A 301 4.979 -12.297 -3.375 1.00 97.82 C \\\\nATOM 2366 O GLY A 301 5.909 -13.049 -3.660 1.00 97.82 O \\\\nATOM 2367 N PHE A 302 3.843 -12.743 -2.830 1.00 97.35 N \\\\nATOM 2368 CA PHE A 302 3.573 -14.155 -2.546 1.00 97.35 C \\\\nATOM 2369 C PHE A 302 2.885 -14.841 -3.740 1.00 97.35 C \\\\nATOM 2370 CB PHE A 302 2.783 -14.263 -1.232 1.00 97.35 C \\\\nATOM 2371 O PHE A 302 2.907 -14.325 -4.856 1.00 97.35 O \\\\nATOM 2372 CG PHE A 302 3.435 -13.594 -0.030 1.00 97.35 C \\\\nATOM 2373 CD1 PHE A 302 4.690 -14.039 0.428 1.00 97.35 C \\\\nATOM 2374 CD2 PHE A 302 2.791 -12.539 0.644 1.00 97.35 C \\\\nATOM 2375 CE1 PHE A 302 5.291 -13.437 1.547 1.00 97.35 C \\\\nATOM 2376 CE2 PHE A 302 3.385 -11.946 1.771 1.00 97.35 C \\\\nATOM 2377 CZ PHE A 302 4.638 -12.392 2.223 1.00 97.35 C \\\\nATOM 2378 N THR A 303 2.335 -16.044 -3.546 1.00 96.72 N \\\\nATOM 2379 CA THR A 303 1.984 -16.964 -4.647 1.00 96.72 C \\\\nATOM 2380 C THR A 303 0.567 -17.547 -4.562 1.00 96.72 C \\\\nATOM 2381 CB THR A 303 3.019 -18.101 -4.740 1.00 96.72 C \\\\nATOM 2382 O THR A 303 0.355 -18.666 -5.015 1.00 96.72 O \\\\nATOM 2383 CG2 THR A 303 4.447 -17.610 -4.978 1.00 96.72 C \\\\nATOM 2384 OG1 THR A 303 3.013 -18.832 -3.534 1.00 96.72 O \\\\nATOM 2385 N ASP A 304 -0.398 -16.851 -3.956 1.00 94.15 N \\\\nATOM 2386 CA ASP A 304 -1.798 -17.309 -3.915 1.00 94.15 C \\\\nATOM 2387 C ASP A 304 -2.532 -16.889 -5.205 1.00 94.15 C \\\\nATOM 2388 CB ASP A 304 -2.473 -16.747 -2.658 1.00 94.15 C \\\\nATOM 2389 O ASP A 304 -2.710 -15.693 -5.423 1.00 94.15 O \\\\nATOM 2390 CG ASP A 304 -3.936 -17.159 -2.451 1.00 94.15 C \\\\nATOM 2391 OD1 ASP A 304 -4.527 -17.856 -3.318 1.00 94.15 O \\\\nATOM 2392 OD2 ASP A 304 -4.436 -16.746 -1.375 1.00 94.15 O \\\\nATOM 2393 N PRO A 305 -2.946 -17.827 -6.077 1.00 91.29 N \\\\nATOM 2394 CA PRO A 305 -3.564 -17.491 -7.360 1.00 91.29 C \\\\nATOM 2395 C PRO A 305 -5.070 -17.204 -7.267 1.00 91.29 C \\\\nATOM 2396 CB PRO A 305 -3.296 -18.721 -8.232 1.00 91.29 C \\\\nATOM 2397 O PRO A 305 -5.663 -16.781 -8.252 1.00 91.29 O \\\\nATOM 2398 CG PRO A 305 -3.376 -19.872 -7.230 1.00 91.29 C \\\\nATOM 2399 CD PRO A 305 -2.768 -19.270 -5.965 1.00 91.29 C \\\\nATOM 2400 N SER A 306 -5.711 -17.495 -6.131 1.00 88.57 N \\\\nATOM 2401 CA SER A 306 -7.172 -17.684 -6.059 1.00 88.57 C \\\\nATOM 2402 C SER A 306 -7.919 -16.630 -5.244 1.00 88.57 C \\\\nATOM 2403 CB SER A 306 -7.461 -19.087 -5.524 1.00 88.57 C \\\\nATOM 2404 O SER A 306 -9.147 -16.650 -5.163 1.00 88.57 O \\\\nATOM 2405 OG SER A 306 -6.983 -19.271 -4.198 1.00 88.57 O \\\\nATOM 2406 N ASN A 307 -7.193 -15.712 -4.614 1.00 87.96 N \\\\nATOM 2407 CA ASN A 307 -7.768 -14.765 -3.675 1.00 87.96 C \\\\nATOM 2408 C ASN A 307 -8.130 -13.440 -4.363 1.00 87.96 C \\\\nATOM 2409 CB ASN A 307 -6.780 -14.647 -2.514 1.00 87.96 C \\\\nATOM 2410 O ASN A 307 -7.258 -12.690 -4.791 1.00 87.96 O \\\\nATOM 2411 CG ASN A 307 -7.307 -13.822 -1.365 1.00 87.96 C \\\\nATOM 2412 ND2 ASN A 307 -6.954 -14.183 -0.156 1.00 87.96 N \\\\nATOM 2413 OD1 ASN A 307 -8.048 -12.869 -1.514 1.00 87.96 O \\\\nATOM 2414 N SER A 308 -9.423 -13.110 -4.406 1.00 89.03 N \\\\nATOM 2415 CA SER A 308 -9.940 -11.878 -5.023 1.00 89.03 C \\\\nATOM 2416 C SER A 308 -9.550 -10.582 -4.298 1.00 89.03 C \\\\nATOM 2417 CB SER A 308 -11.465 -11.960 -5.118 1.00 89.03 C \\\\nATOM 2418 O SER A 308 -9.783 -9.498 -4.821 1.00 89.03 O \\\\nATOM 2419 OG SER A 308 -12.037 -12.143 -3.834 1.00 89.03 O \\\\nATOM 2420 N GLU A 309 -8.983 -10.665 -3.094 1.00 92.14 N \\\\nATOM 2421 CA GLU A 309 -8.434 -9.529 -2.341 1.00 92.14 C \\\\nATOM 2422 C GLU A 309 -6.903 -9.457 -2.441 1.00 92.14 C \\\\nATOM 2423 CB GLU A 309 -8.846 -9.615 -0.863 1.00 92.14 C \\\\nATOM 2424 O GLU A 309 -6.290 -8.568 -1.843 1.00 92.14 O \\\\nATOM 2425 CG GLU A 309 -10.360 -9.535 -0.631 1.00 92.14 C \\\\nATOM 2426 CD GLU A 309 -10.740 -9.691 0.853 1.00 92.14 C \\\\nATOM 2427 OE1 GLU A 309 -11.953 -9.833 1.122 1.00 92.14 O \\\\nATOM 2428 OE2 GLU A 309 -9.837 -9.684 1.728 1.00 92.14 O \\\\nATOM 2429 N ARG A 310 -6.252 -10.390 -3.154 1.00 96.04 N \\\\nATOM 2430 CA ARG A 310 -4.791 -10.445 -3.258 1.00 96.04 C \\\\nATOM 2431 C ARG A 310 -4.327 -10.595 -4.697 1.00 96.04 C \\\\nATOM 2432 CB ARG A 310 -4.203 -11.564 -2.396 1.00 96.04 C \\\\nATOM 2433 O ARG A 310 -4.538 -11.619 -5.333 1.00 96.04 O \\\\nATOM 2434 CG ARG A 310 -4.527 -11.394 -0.906 1.00 96.04 C \\\\nATOM 2435 CD ARG A 310 -3.942 -12.550 -0.098 1.00 96.04 C \\\\nATOM 2436 NE ARG A 310 -2.472 -12.565 -0.148 1.00 96.04 N \\\\nATOM 2437 NH1 ARG A 310 -2.160 -14.826 0.181 1.00 96.04 N \\\\nATOM 2438 NH2 ARG A 310 -0.422 -13.452 -0.107 1.00 96.04 N \\\\nATOM 2439 CZ ARG A 310 -1.701 -13.620 -0.017 1.00 96.04 C \\\\nATOM 2440 N PHE A 311 -3.589 -9.599 -5.170 1.00 97.27 N \\\\nATOM 2441 CA PHE A 311 -2.848 -9.704 -6.414 1.00 97.27 C \\\\nATOM 2442 C PHE A 311 -1.417 -10.164 -6.116 1.00 97.27 C \\\\nATOM 2443 CB PHE A 311 -2.922 -8.385 -7.183 1.00 97.27 C \\\\nATOM 2444 O PHE A 311 -0.531 -9.370 -5.791 1.00 97.27 O \\\\nATOM 2445 CG PHE A 311 -2.310 -8.407 -8.574 1.00 97.27 C \\\\nATOM 2446 CD1 PHE A 311 -1.940 -7.188 -9.172 1.00 97.27 C \\\\nATOM 2447 CD2 PHE A 311 -2.148 -9.609 -9.300 1.00 97.27 C \\\\nATOM 2448 CE1 PHE A 311 -1.416 -7.167 -10.476 1.00 97.27 C \\\\nATOM 2449 CE2 PHE A 311 -1.618 -9.587 -10.599 1.00 97.27 C \\\\nATOM 2450 CZ PHE A 311 -1.255 -8.367 -11.190 1.00 97.27 C \\\\nATOM 2451 N CYS A 312 -1.209 -11.476 -6.173 1.00 97.36 N \\\\nATOM 2452 CA CYS A 312 0.056 -12.118 -5.839 1.00 97.36 C \\\\nATOM 2453 C CYS A 312 1.023 -12.116 -7.031 1.00 97.36 C \\\\nATOM 2454 CB CYS A 312 -0.262 -13.530 -5.345 1.00 97.36 C \\\\nATOM 2455 O CYS A 312 0.951 -12.957 -7.924 1.00 97.36 O \\\\nATOM 2456 SG CYS A 312 -0.905 -13.448 -3.650 1.00 97.36 S \\\\nATOM 2457 N LEU A 313 1.981 -11.193 -7.027 1.00 97.92 N \\\\nATOM 2458 CA LEU A 313 2.961 -11.027 -8.100 1.00 97.92 C \\\\nATOM 2459 C LEU A 313 3.986 -12.164 -8.147 1.00 97.92 C \\\\nATOM 2460 CB LEU A 313 3.682 -9.679 -7.923 1.00 97.92 C \\\\nATOM 2461 O LEU A 313 4.587 -12.400 -9.197 1.00 97.92 O \\\\nATOM 2462 CG LEU A 313 2.757 -8.448 -7.849 1.00 97.92 C \\\\nATOM 2463 CD1 LEU A 313 3.620 -7.194 -7.709 1.00 97.92 C \\\\nATOM 2464 CD2 LEU A 313 1.873 -8.320 -9.087 1.00 97.92 C \\\\nATOM 2465 N GLY A 314 4.205 -12.865 -7.030 1.00 97.10 N \\\\nATOM 2466 CA GLY A 314 5.233 -13.897 -6.866 1.00 97.10 C \\\\nATOM 2467 C GLY A 314 5.062 -15.102 -7.791 1.00 97.10 C \\\\nATOM 2468 O GLY A 314 6.067 -15.654 -8.237 1.00 97.10 O \\\\nATOM 2469 N LEU A 315 3.819 -15.453 -8.143 1.00 95.97 N \\\\nATOM 2470 CA LEU A 315 3.499 -16.566 -9.051 1.00 95.97 C \\\\nATOM 2471 C LEU A 315 3.662 -16.217 -10.539 1.00 95.97 C \\\\nATOM 2472 CB LEU A 315 2.086 -17.092 -8.729 1.00 95.97 C \\\\nATOM 2473 O LEU A 315 3.755 -17.111 -11.380 1.00 95.97 O \\\\nATOM 2474 CG LEU A 315 0.935 -16.120 -9.073 1.00 95.97 C \\\\nATOM 2475 CD1 LEU A 315 0.299 -16.433 -10.426 1.00 95.97 C \\\\nATOM 2476 CD2 LEU A 315 -0.157 -16.195 -8.008 1.00 95.97 C \\\\nATOM 2477 N LEU A 316 3.706 -14.925 -10.878 1.00 96.99 N \\\\nATOM 2478 CA LEU A 316 3.794 -14.481 -12.265 1.00 96.99 C \\\\nATOM 2479 C LEU A 316 5.173 -14.805 -12.842 1.00 96.99 C \\\\nATOM 2480 CB LEU A 316 3.471 -12.984 -12.385 1.00 96.99 C \\\\nATOM 2481 O LEU A 316 6.210 -14.418 -12.291 1.00 96.99 O \\\\nATOM 2482 CG LEU A 316 2.113 -12.561 -11.798 1.00 96.99 C \\\\nATOM 2483 CD1 LEU A 316 1.944 -11.053 -11.957 1.00 96.99 C \\\\nATOM 2484 CD2 LEU A 316 0.944 -13.261 -12.490 1.00 96.99 C \\\\nATOM 2485 N SER A 317 5.184 -15.500 -13.972 1.00 96.68 N \\\\nATOM 2486 CA SER A 317 6.404 -15.879 -14.683 1.00 96.68 C \\\\nATOM 2487 C SER A 317 6.768 -14.847 -15.747 1.00 96.68 C \\\\nATOM 2488 CB SER A 317 6.244 -17.279 -15.274 1.00 96.68 C \\\\nATOM 2489 O SER A 317 5.897 -14.247 -16.368 1.00 96.68 O \\\\nATOM 2490 OG SER A 317 6.150 -18.211 -14.215 1.00 96.68 O \\\\nATOM 2491 N ASN A 318 8.068 -14.645 -15.957 1.00 96.83 N \\\\nATOM 2492 CA ASN A 318 8.603 -13.826 -17.038 1.00 96.83 C \\\\nATOM 2493 C ASN A 318 9.930 -14.436 -17.500 1.00 96.83 C \\\\nATOM 2494 CB ASN A 318 8.779 -12.374 -16.559 1.00 96.83 C \\\\nATOM 2495 O ASN A 318 10.871 -14.531 -16.712 1.00 96.83 O \\\\nATOM 2496 CG ASN A 318 9.386 -11.484 -17.632 1.00 96.83 C \\\\nATOM 2497 ND2 ASN A 318 9.829 -10.306 -17.276 1.00 96.83 N \\\\nATOM 2498 OD1 ASN A 318 9.485 -11.850 -18.793 1.00 96.83 O \\\\nATOM 2499 N VAL A 319 10.000 -14.848 -18.766 1.00 97.17 N \\\\nATOM 2500 CA VAL A 319 11.196 -15.471 -19.359 1.00 97.17 C \\\\nATOM 2501 C VAL A 319 12.351 -14.482 -19.547 1.00 97.17 C \\\\nATOM 2502 CB VAL A 319 10.863 -16.166 -20.694 1.00 97.17 C \\\\nATOM 2503 O VAL A 319 13.506 -14.891 -19.538 1.00 97.17 O \\\\nATOM 2504 CG1 VAL A 319 9.882 -17.326 -20.475 1.00 97.17 C \\\\nATOM 2505 CG2 VAL A 319 10.269 -15.208 -21.737 1.00 97.17 C \\\\nATOM 2506 N ASN A 320 12.057 -13.181 -19.638 1.00 96.50 N \\\\nATOM 2507 CA ASN A 320 13.054 -12.117 -19.802 1.00 96.50 C \\\\nATOM 2508 C ASN A 320 13.523 -11.529 -18.459 1.00 96.50 C \\\\nATOM 2509 CB ASN A 320 12.464 -11.029 -20.705 1.00 96.50 C \\\\nATOM 2510 O ASN A 320 14.186 -10.488 -18.414 1.00 96.50 O \\\\nATOM 2511 CG ASN A 320 12.086 -11.526 -22.084 1.00 96.50 C \\\\nATOM 2512 ND2 ASN A 320 11.033 -10.985 -22.645 1.00 96.50 N \\\\nATOM 2513 OD1 ASN A 320 12.723 -12.384 -22.669 1.00 96.50 O \\\\nATOM 2514 N ARG A 321 13.147 -12.154 -17.338 1.00 97.58 N \\\\nATOM 2515 CA ARG A 321 13.455 -11.652 -16.001 1.00 97.58 C \\\\nATOM 2516 C ARG A 321 14.955 -11.720 -15.729 1.00 97.58 C \\\\nATOM 2517 CB ARG A 321 12.655 -12.456 -14.978 1.00 97.58 C \\\\nATOM 2518 O ARG A 321 15.547 -12.792 -15.714 1.00 97.58 O \\\\nATOM 2519 CG ARG A 321 12.835 -11.900 -13.562 1.00 97.58 C \\\\nATOM 2520 CD ARG A 321 11.934 -12.637 -12.575 1.00 97.58 C \\\\nATOM 2521 NE ARG A 321 10.512 -12.373 -12.857 1.00 97.58 N \\\\nATOM 2522 NH1 ARG A 321 9.606 -14.398 -12.205 1.00 97.58 N \\\\nATOM 2523 NH2 ARG A 321 8.307 -12.773 -12.966 1.00 97.58 N \\\\nATOM 2524 CZ ARG A 321 9.494 -13.189 -12.681 1.00 97.58 C \\\\nATOM 2525 N ASN A 322 15.557 -10.570 -15.437 1.00 97.73 N \\\\nATOM 2526 CA ASN A 322 16.963 -10.493 -15.040 1.00 97.73 C \\\\nATOM 2527 C ASN A 322 17.152 -10.588 -13.511 1.00 97.73 C \\\\nATOM 2528 CB ASN A 322 17.599 -9.249 -15.686 1.00 97.73 C \\\\nATOM 2529 O ASN A 322 16.209 -10.436 -12.729 1.00 97.73 O \\\\nATOM 2530 CG ASN A 322 17.151 -7.924 -15.094 1.00 97.73 C \\\\nATOM 2531 ND2 ASN A 322 16.987 -6.916 -15.913 1.00 97.73 N \\\\nATOM 2532 OD1 ASN A 322 16.995 -7.756 -13.892 1.00 97.73 O \\\\nATOM 2533 N ALA A 323 18.404 -10.758 -13.075 1.00 98.07 N \\\\nATOM 2534 CA ALA A 323 18.758 -10.909 -11.661 1.00 98.07 C \\\\nATOM 2535 C ALA A 323 18.328 -9.721 -10.772 1.00 98.07 C \\\\nATOM 2536 CB ALA A 323 20.276 -11.121 -11.582 1.00 98.07 C \\\\nATOM 2537 O ALA A 323 17.970 -9.910 -9.609 1.00 98.07 O \\\\nATOM 2538 N THR A 324 18.318 -8.489 -11.304 1.00 97.78 N \\\\nATOM 2539 CA THR A 324 17.886 -7.300 -10.543 1.00 97.78 C \\\\nATOM 2540 C THR A 324 16.382 -7.333 -10.272 1.00 97.78 C \\\\nATOM 2541 CB THR A 324 18.247 -5.996 -11.274 1.00 97.78 C \\\\nATOM 2542 O THR A 324 15.947 -7.012 -9.162 1.00 97.78 O \\\\nATOM 2543 CG2 THR A 324 17.804 -4.742 -10.517 1.00 97.78 C \\\\nATOM 2544 OG1 THR A 324 19.643 -5.883 -11.404 1.00 97.78 O \\\\nATOM 2545 N VAL A 325 15.585 -7.737 -11.264 1.00 98.29 N \\\\nATOM 2546 CA VAL A 325 14.136 -7.931 -11.116 1.00 98.29 C \\\\nATOM 2547 C VAL A 325 13.861 -9.056 -10.125 1.00 98.29 C \\\\nATOM 2548 CB VAL A 325 13.481 -8.218 -12.478 1.00 98.29 C \\\\nATOM 2549 O VAL A 325 13.096 -8.871 -9.184 1.00 98.29 O \\\\nATOM 2550 CG1 VAL A 325 11.986 -8.490 -12.319 1.00 98.29 C \\\\nATOM 2551 CG2 VAL A 325 13.630 -7.049 -13.462 1.00 98.29 C \\\\nATOM 2552 N GLU A 326 14.549 -10.189 -10.255 1.00 97.74 N \\\\nATOM 2553 CA GLU A 326 14.381 -11.326 -9.349 1.00 97.74 C \\\\nATOM 2554 C GLU A 326 14.725 -10.975 -7.890 1.00 97.74 C \\\\nATOM 2555 CB GLU A 326 15.262 -12.471 -9.852 1.00 97.74 C \\\\nATOM 2556 O GLU A 326 14.016 -11.359 -6.960 1.00 97.74 O \\\\nATOM 2557 CG GLU A 326 14.721 -13.828 -9.395 1.00 97.74 C \\\\nATOM 2558 CD GLU A 326 15.759 -14.933 -9.594 1.00 97.74 C \\\\nATOM 2559 OE1 GLU A 326 15.776 -15.832 -8.727 1.00 97.74 O \\\\nATOM 2560 OE2 GLU A 326 16.610 -14.789 -10.490 1.00 97.74 O \\\\nATOM 2561 N MET A 327 15.794 -10.209 -7.659 1.00 97.59 N \\\\nATOM 2562 CA MET A 327 16.147 -9.710 -6.327 1.00 97.59 C \\\\nATOM 2563 C MET A 327 15.103 -8.722 -5.792 1.00 97.59 C \\\\nATOM 2564 CB MET A 327 17.539 -9.070 -6.389 1.00 97.59 C \\\\nATOM 2565 O MET A 327 14.763 -8.762 -4.611 1.00 97.59 O \\\\nATOM 2566 CG MET A 327 18.035 -8.631 -5.006 1.00 97.59 C \\\\nATOM 2567 SD MET A 327 19.672 -7.856 -5.020 1.00 97.59 S \\\\nATOM 2568 CE MET A 327 20.725 -9.310 -5.290 1.00 97.59 C \\\\nATOM 2569 N THR A 328 14.567 -7.855 -6.653 1.00 98.24 N \\\\nATOM 2570 CA THR A 328 13.542 -6.872 -6.271 1.00 98.24 C \\\\nATOM 2571 C THR A 328 12.232 -7.556 -5.877 1.00 98.24 C \\\\nATOM 2572 CB THR A 328 13.318 -5.853 -7.398 1.00 98.24 C \\\\nATOM 2573 O THR A 328 11.670 -7.224 -4.836 1.00 98.24 O \\\\nATOM 2574 CG2 THR A 328 12.306 -4.781 -7.010 1.00 98.24 C \\\\nATOM 2575 OG1 THR A 328 14.542 -5.197 -7.673 1.00 98.24 O \\\\nATOM 2576 N ARG A 329 11.798 -8.577 -6.628 1.00 98.35 N \\\\nATOM 2577 CA ARG A 329 10.590 -9.370 -6.335 1.00 98.35 C \\\\nATOM 2578 C ARG A 329 10.609 -9.990 -4.937 1.00 98.35 C \\\\nATOM 2579 CB ARG A 329 10.412 -10.460 -7.402 1.00 98.35 C \\\\nATOM 2580 O ARG A 329 9.590 -9.963 -4.254 1.00 98.35 O \\\\nATOM 2581 CG ARG A 329 9.955 -9.872 -8.744 1.00 98.35 C \\\\nATOM 2582 CD ARG A 329 10.008 -10.903 -9.872 1.00 98.35 C \\\\nATOM 2583 NE ARG A 329 9.130 -12.058 -9.617 1.00 98.35 N \\\\nATOM 2584 NH1 ARG A 329 7.139 -11.118 -10.318 1.00 98.35 N \\\\nATOM 2585 NH2 ARG A 329 7.166 -13.166 -9.480 1.00 98.35 N \\\\nATOM 2586 CZ ARG A 329 7.825 -12.099 -9.806 1.00 98.35 C \\\\nATOM 2587 N ARG A 330 11.773 -10.465 -4.472 1.00 97.77 N \\\\nATOM 2588 CA ARG A 330 11.949 -11.017 -3.111 1.00 97.77 C \\\\nATOM 2589 C ARG A 330 11.653 -10.000 -2.003 1.00 97.77 C \\\\nATOM 2590 CB ARG A 330 13.377 -11.557 -2.929 1.00 97.77 C \\\\nATOM 2591 O ARG A 330 11.192 -10.388 -0.938 1.00 97.77 O \\\\nATOM 2592 CG ARG A 330 13.676 -12.800 -3.778 1.00 97.77 C \\\\nATOM 2593 CD ARG A 330 15.146 -13.199 -3.598 1.00 97.77 C \\\\nATOM 2594 NE ARG A 330 15.505 -14.389 -4.391 1.00 97.77 N \\\\nATOM 2595 NH1 ARG A 330 16.166 -13.356 -6.344 1.00 97.77 N \\\\nATOM 2596 NH2 ARG A 330 16.360 -15.551 -6.138 1.00 97.77 N \\\\nATOM 2597 CZ ARG A 330 16.011 -14.419 -5.612 1.00 97.77 C \\\\nATOM 2598 N HIS A 331 11.891 -8.714 -2.261 1.00 97.91 N \\\\nATOM 2599 CA HIS A 331 11.701 -7.631 -1.292 1.00 97.91 C \\\\nATOM 2600 C HIS A 331 10.309 -6.993 -1.356 1.00 97.91 C \\\\nATOM 2601 CB HIS A 331 12.799 -6.580 -1.485 1.00 97.91 C \\\\nATOM 2602 O HIS A 331 9.998 -6.134 -0.536 1.00 97.91 O \\\\nATOM 2603 CG HIS A 331 14.171 -7.075 -1.124 1.00 97.91 C \\\\nATOM 2604 CD2 HIS A 331 14.804 -6.915 0.079 1.00 97.91 C \\\\nATOM 2605 ND1 HIS A 331 15.028 -7.762 -1.952 1.00 97.91 N \\\\nATOM 2606 CE1 HIS A 331 16.153 -8.011 -1.265 1.00 97.91 C \\\\nATOM 2607 NE2 HIS A 331 16.067 -7.506 -0.028 1.00 97.91 N \\\\nATOM 2608 N ILE A 332 9.444 -7.410 -2.291 1.00 98.33 N \\\\nATOM 2609 CA ILE A 332 8.044 -6.968 -2.289 1.00 98.33 C \\\\nATOM 2610 C ILE A 332 7.382 -7.439 -0.989 1.00 98.33 C \\\\nATOM 2611 CB ILE A 332 7.289 -7.454 -3.548 1.00 98.33 C \\\\nATOM 2612 O ILE A 332 6.767 -6.633 -0.291 1.00 98.33 O \\\\nATOM 2613 CG1 ILE A 332 7.951 -6.868 -4.816 1.00 98.33 C \\\\nATOM 2614 CG2 ILE A 332 5.803 -7.051 -3.477 1.00 98.33 C \\\\nATOM 2615 CD1 ILE A 332 7.322 -7.321 -6.138 1.00 98.33 C \\\\nATOM 2616 N GLY A 333 7.564 -8.710 -0.613 1.00 96.97 N \\\\nATOM 2617 CA GLY A 333 7.011 -9.267 0.622 1.00 96.97 C \\\\nATOM 2618 C GLY A 333 5.499 -9.059 0.688 1.00 96.97 C \\\\nATOM 2619 O GLY A 333 4.781 -9.431 -0.234 1.00 96.97 O \\\\nATOM 2620 N ARG A 334 5.014 -8.404 1.747 1.00 96.99 N \\\\nATOM 2621 CA ARG A 334 3.590 -8.052 1.914 1.00 96.99 C \\\\nATOM 2622 C ARG A 334 3.105 -6.923 0.990 1.00 96.99 C \\\\nATOM 2623 CB ARG A 334 3.332 -7.682 3.376 1.00 96.99 C \\\\nATOM 2624 O ARG A 334 1.907 -6.669 0.949 1.00 96.99 O \\\\nATOM 2625 CG ARG A 334 3.610 -8.820 4.371 1.00 96.99 C \\\\nATOM 2626 CD ARG A 334 3.509 -8.312 5.813 1.00 96.99 C \\\\nATOM 2627 NE ARG A 334 2.156 -7.801 6.116 1.00 96.99 N \\\\nATOM 2628 NH1 ARG A 334 2.778 -6.270 7.713 1.00 96.99 N \\\\nATOM 2629 NH2 ARG A 334 0.650 -6.379 7.050 1.00 96.99 N \\\\nATOM 2630 CZ ARG A 334 1.871 -6.829 6.963 1.00 96.99 C \\\\nATOM 2631 N GLY A 335 4.019 -6.256 0.284 1.00 97.95 N \\\\nATOM 2632 CA GLY A 335 3.738 -5.303 -0.786 1.00 97.95 C \\\\nATOM 2633 C GLY A 335 2.956 -4.063 -0.355 1.00 97.95 C \\\\nATOM 2634 O GLY A 335 3.332 -3.387 0.604 1.00 97.95 O \\\\nATOM 2635 N VAL A 336 1.898 -3.735 -1.094 1.00 98.47 N \\\\nATOM 2636 CA VAL A 336 1.054 -2.552 -0.872 1.00 98.47 C \\\\nATOM 2637 C VAL A 336 -0.393 -2.973 -0.664 1.00 98.47 C \\\\nATOM 2638 CB VAL A 336 1.204 -1.522 -2.012 1.00 98.47 C \\\\nATOM 2639 O VAL A 336 -0.916 -3.807 -1.401 1.00 98.47 O \\\\nATOM 2640 CG1 VAL A 336 0.789 -2.047 -3.392 1.00 98.47 C \\\\nATOM 2641 CG2 VAL A 336 0.412 -0.237 -1.741 1.00 98.47 C \\\\nATOM 2642 N ARG A 337 -1.062 -2.375 0.322 1.00 97.58 N \\\\nATOM 2643 CA ARG A 337 -2.518 -2.443 0.435 1.00 97.58 C \\\\nATOM 2644 C ARG A 337 -3.132 -1.201 -0.182 1.00 97.58 C \\\\nATOM 2645 CB ARG A 337 -2.931 -2.656 1.887 1.00 97.58 C \\\\nATOM 2646 O ARG A 337 -2.751 -0.086 0.167 1.00 97.58 O \\\\nATOM 2647 CG ARG A 337 -4.458 -2.695 2.038 1.00 97.58 C \\\\nATOM 2648 CD ARG A 337 -4.849 -2.850 3.499 1.00 97.58 C \\\\nATOM 2649 NE ARG A 337 -4.440 -4.165 4.015 1.00 97.58 N \\\\nATOM 2650 NH1 ARG A 337 -4.005 -3.476 6.154 1.00 97.58 N \\\\nATOM 2651 NH2 ARG A 337 -4.062 -5.673 5.649 1.00 97.58 N \\\\nATOM 2652 CZ ARG A 337 -4.166 -4.427 5.272 1.00 97.58 C \\\\nATOM 2653 N LEU A 338 -4.098 -1.415 -1.063 1.00 97.59 N \\\\nATOM 2654 CA LEU A 338 -4.912 -0.367 -1.655 1.00 97.59 C \\\\nATOM 2655 C LEU A 338 -6.320 -0.481 -1.098 1.00 97.59 C \\\\nATOM 2656 CB LEU A 338 -4.897 -0.468 -3.187 1.00 97.59 C \\\\nATOM 2657 O LEU A 338 -6.879 -1.579 -1.059 1.00 97.59 O \\\\nATOM 2658 CG LEU A 338 -3.497 -0.423 -3.817 1.00 97.59 C \\\\nATOM 2659 CD1 LEU A 338 -3.606 -0.648 -5.321 1.00 97.59 C \\\\nATOM 2660 CD2 LEU A 338 -2.817 0.921 -3.570 1.00 97.59 C \\\\nATOM 2661 N TYR A 339 -6.886 0.635 -0.657 1.00 94.29 N \\\\nATOM 2662 CA TYR A 339 -8.265 0.657 -0.192 1.00 94.29 C \\\\nATOM 2663 C TYR A 339 -9.008 1.896 -0.686 1.00 94.29 C \\\\nATOM 2664 CB TYR A 339 -8.335 0.456 1.329 1.00 94.29 C \\\\nATOM 2665 O TYR A 339 -8.458 2.998 -0.687 1.00 94.29 O \\\\nATOM 2666 CG TYR A 339 -7.543 1.443 2.169 1.00 94.29 C \\\\nATOM 2667 CD1 TYR A 339 -6.210 1.165 2.529 1.00 94.29 C \\\\nATOM 2668 CD2 TYR A 339 -8.145 2.635 2.605 1.00 94.29 C \\\\nATOM 2669 CE1 TYR A 339 -5.487 2.074 3.325 1.00 94.29 C \\\\nATOM 2670 CE2 TYR A 339 -7.443 3.529 3.435 1.00 94.29 C \\\\nATOM 2671 OH TYR A 339 -5.372 4.184 4.461 1.00 94.29 O \\\\nATOM 2672 CZ TYR A 339 -6.099 3.260 3.778 1.00 94.29 C \\\\nATOM 2673 N TYR A 340 -10.252 1.677 -1.109 1.00 94.08 N \\\\nATOM 2674 CA TYR A 340 -11.198 2.666 -1.603 1.00 94.08 C \\\\nATOM 2675 C TYR A 340 -12.298 2.883 -0.566 1.00 94.08 C \\\\nATOM 2676 CB TYR A 340 -11.787 2.203 -2.940 1.00 94.08 C \\\\nATOM 2677 O TYR A 340 -13.059 1.967 -0.251 1.00 94.08 O \\\\nATOM 2678 CG TYR A 340 -12.829 3.157 -3.495 1.00 94.08 C \\\\nATOM 2679 CD1 TYR A 340 -14.131 2.706 -3.792 1.00 94.08 C \\\\nATOM 2680 CD2 TYR A 340 -12.493 4.507 -3.719 1.00 94.08 C \\\\nATOM 2681 CE1 TYR A 340 -15.084 3.595 -4.329 1.00 94.08 C \\\\nATOM 2682 CE2 TYR A 340 -13.440 5.394 -4.262 1.00 94.08 C \\\\nATOM 2683 OH TYR A 340 -15.648 5.811 -5.089 1.00 94.08 O \\\\nATOM 2684 CZ TYR A 340 -14.740 4.941 -4.572 1.00 94.08 C \\\\nATOM 2685 N ILE A 341 -12.338 4.078 0.021 1.00 89.81 N \\\\nATOM 2686 CA ILE A 341 -13.234 4.410 1.131 1.00 89.81 C \\\\nATOM 2687 C ILE A 341 -13.700 5.849 0.976 1.00 89.81 C \\\\nATOM 2688 CB ILE A 341 -12.529 4.199 2.489 1.00 89.81 C \\\\nATOM 2689 O ILE A 341 -12.882 6.758 0.866 1.00 89.81 O \\\\nATOM 2690 CG1 ILE A 341 -12.080 2.726 2.624 1.00 89.81 C \\\\nATOM 2691 CG2 ILE A 341 -13.460 4.596 3.652 1.00 89.81 C \\\\nATOM 2692 CD1 ILE A 341 -11.307 2.440 3.893 1.00 89.81 C \\\\nATOM 2693 N GLY A 342 -15.016 6.063 0.993 1.00 86.14 N \\\\nATOM 2694 CA GLY A 342 -15.597 7.405 0.992 1.00 86.14 C \\\\nATOM 2695 C GLY A 342 -15.259 8.241 -0.249 1.00 86.14 C \\\\nATOM 2696 O GLY A 342 -15.158 9.458 -0.142 1.00 86.14 O \\\\nATOM 2697 N GLY A 343 -15.028 7.616 -1.409 1.00 91.06 N \\\\nATOM 2698 CA GLY A 343 -14.581 8.324 -2.616 1.00 91.06 C \\\\nATOM 2699 C GLY A 343 -13.084 8.656 -2.634 1.00 91.06 C \\\\nATOM 2700 O GLY A 343 -12.636 9.430 -3.477 1.00 91.06 O \\\\nATOM 2701 N GLU A 344 -12.297 8.093 -1.718 1.00 95.31 N \\\\nATOM 2702 CA GLU A 344 -10.852 8.298 -1.624 1.00 95.31 C \\\\nATOM 2703 C GLU A 344 -10.106 6.972 -1.770 1.00 95.31 C \\\\nATOM 2704 CB GLU A 344 -10.482 8.970 -0.295 1.00 95.31 C \\\\nATOM 2705 O GLU A 344 -10.546 5.940 -1.260 1.00 95.31 O \\\\nATOM 2706 CG GLU A 344 -11.302 10.232 -0.002 1.00 95.31 C \\\\nATOM 2707 CD GLU A 344 -10.703 11.044 1.148 1.00 95.31 C \\\\nATOM 2708 OE1 GLU A 344 -10.492 12.263 0.951 1.00 95.31 O \\\\nATOM 2709 OE2 GLU A 344 -10.289 10.495 2.196 1.00 95.31 O \\\\nATOM 2710 N VAL A 345 -8.951 6.998 -2.437 1.00 97.02 N \\\\nATOM 2711 CA VAL A 345 -8.064 5.834 -2.562 1.00 97.02 C \\\\nATOM 2712 C VAL A 345 -6.793 6.093 -1.773 1.00 97.02 C \\\\nATOM 2713 CB VAL A 345 -7.734 5.471 -4.021 1.00 97.02 C \\\\nATOM 2714 O VAL A 345 -6.159 7.145 -1.907 1.00 97.02 O \\\\nATOM 2715 CG1 VAL A 345 -6.968 4.143 -4.103 1.00 97.02 C \\\\nATOM 2716 CG2 VAL A 345 -8.986 5.315 -4.892 1.00 97.02 C \\\\nATOM 2717 N PHE A 346 -6.380 5.106 -0.989 1.00 97.07 N \\\\nATOM 2718 CA PHE A 346 -5.151 5.148 -0.209 1.00 97.07 C \\\\nATOM 2719 C PHE A 346 -4.224 3.991 -0.574 1.00 97.07 C \\\\nATOM 2720 CB PHE A 346 -5.493 5.078 1.271 1.00 97.07 C \\\\nATOM 2721 O PHE A 346 -4.683 2.895 -0.893 1.00 97.07 O \\\\nATOM 2722 CG PHE A 346 -6.297 6.235 1.835 1.00 97.07 C \\\\nATOM 2723 CD1 PHE A 346 -5.655 7.239 2.584 1.00 97.07 C \\\\nATOM 2724 CD2 PHE A 346 -7.695 6.276 1.669 1.00 97.07 C \\\\nATOM 2725 CE1 PHE A 346 -6.405 8.281 3.159 1.00 97.07 C \\\\nATOM 2726 CE2 PHE A 346 -8.443 7.312 2.250 1.00 97.07 C \\\\nATOM 2727 CZ PHE A 346 -7.800 8.318 2.989 1.00 97.07 C \\\\nATOM 2728 N ALA A 347 -2.919 4.234 -0.463 1.00 97.96 N \\\\nATOM 2729 CA ALA A 347 -1.883 3.211 -0.516 1.00 97.96 C \\\\nATOM 2730 C ALA A 347 -1.181 3.105 0.840 1.00 97.96 C \\\\nATOM 2731 CB ALA A 347 -0.893 3.540 -1.640 1.00 97.96 C \\\\nATOM 2732 O ALA A 347 -0.631 4.091 1.324 1.00 97.96 O \\\\nATOM 2733 N GLU A 348 -1.175 1.913 1.434 1.00 97.60 N \\\\nATOM 2734 CA GLU A 348 -0.460 1.568 2.668 1.00 97.60 C \\\\nATOM 2735 C GLU A 348 0.707 0.628 2.335 1.00 97.60 C \\\\nATOM 2736 CB GLU A 348 -1.450 0.952 3.679 1.00 97.60 C \\\\nATOM 2737 O GLU A 348 0.514 -0.455 1.775 1.00 97.60 O \\\\nATOM 2738 CG GLU A 348 -0.813 0.537 5.019 1.00 97.60 C \\\\nATOM 2739 CD GLU A 348 -1.741 -0.274 5.959 1.00 97.60 C \\\\nATOM 2740 OE1 GLU A 348 -1.431 -0.329 7.170 1.00 97.60 O \\\\nATOM 2741 OE2 GLU A 348 -2.691 -0.964 5.499 1.00 97.60 O \\\\nATOM 2742 N CYS A 349 1.932 1.025 2.684 1.00 97.68 N \\\\nATOM 2743 CA CYS A 349 3.120 0.208 2.464 1.00 97.68 C \\\\nATOM 2744 C CYS A 349 3.221 -0.877 3.542 1.00 97.68 C \\\\nATOM 2745 CB CYS A 349 4.354 1.110 2.436 1.00 97.68 C \\\\nATOM 2746 O CYS A 349 3.591 -0.606 4.685 1.00 97.68 O \\\\nATOM 2747 SG CYS A 349 5.812 0.141 1.956 1.00 97.68 S \\\\nATOM 2748 N LEU A 350 2.915 -2.121 3.168 1.00 97.08 N \\\\nATOM 2749 CA LEU A 350 3.031 -3.288 4.046 1.00 97.08 C \\\\nATOM 2750 C LEU A 350 4.384 -3.999 3.924 1.00 97.08 C \\\\nATOM 2751 CB LEU A 350 1.897 -4.273 3.731 1.00 97.08 C \\\\nATOM 2752 O LEU A 350 4.718 -4.808 4.790 1.00 97.08 O \\\\nATOM 2753 CG LEU A 350 0.470 -3.734 3.912 1.00 97.08 C \\\\nATOM 2754 CD1 LEU A 350 -0.500 -4.899 3.700 1.00 97.08 C \\\\nATOM 2755 CD2 LEU A 350 0.237 -3.171 5.314 1.00 97.08 C \\\\nATOM 2756 N SER A 351 5.112 -3.742 2.837 1.00 97.55 N \\\\nATOM 2757 CA SER A 351 6.471 -4.219 2.599 1.00 97.55 C \\\\nATOM 2758 C SER A 351 7.459 -3.616 3.600 1.00 97.55 C \\\\nATOM 2759 CB SER A 351 6.889 -3.842 1.174 1.00 97.55 C \\\\nATOM 2760 O SER A 351 7.312 -2.464 4.008 1.00 97.55 O \\\\nATOM 2761 OG SER A 351 8.183 -4.338 0.888 1.00 97.55 O \\\\nATOM 2762 N ASP A 352 8.506 -4.376 3.928 1.00 97.73 N \\\\nATOM 2763 CA ASP A 352 9.672 -3.889 4.679 1.00 97.73 C \\\\nATOM 2764 C ASP A 352 10.552 -2.948 3.829 1.00 97.73 C \\\\nATOM 2765 CB ASP A 352 10.497 -5.086 5.177 1.00 97.73 C \\\\nATOM 2766 O ASP A 352 11.463 -2.295 4.335 1.00 97.73 O \\\\nATOM 2767 CG ASP A 352 9.687 -6.060 6.040 1.00 97.73 C \\\\nATOM 2768 OD1 ASP A 352 8.900 -5.590 6.891 1.00 97.73 O \\\\nATOM 2769 OD2 ASP A 352 9.822 -7.280 5.800 1.00 97.73 O \\\\nATOM 2770 N SER A 353 10.281 -2.861 2.523 1.00 97.87 N \\\\nATOM 2771 CA SER A 353 10.881 -1.908 1.590 1.00 97.87 C \\\\nATOM 2772 C SER A 353 9.872 -0.838 1.176 1.00 97.87 C \\\\nATOM 2773 CB SER A 353 11.387 -2.646 0.355 1.00 97.87 C \\\\nATOM 2774 O SER A 353 8.687 -1.110 1.029 1.00 97.87 O \\\\nATOM 2775 OG SER A 353 12.472 -3.474 0.711 1.00 97.87 O \\\\nATOM 2776 N ALA A 354 10.346 0.386 0.938 1.00 98.19 N \\\\nATOM 2777 CA ALA A 354 9.480 1.481 0.503 1.00 98.19 C \\\\nATOM 2778 C ALA A 354 8.854 1.226 -0.880 1.00 98.19 C \\\\nATOM 2779 CB ALA A 354 10.281 2.789 0.517 1.00 98.19 C \\\\nATOM 2780 O ALA A 354 9.454 0.578 -1.746 1.00 98.19 O \\\\nATOM 2781 N ILE A 355 7.686 1.826 -1.100 1.00 98.61 N \\\\nATOM 2782 CA ILE A 355 7.050 1.953 -2.416 1.00 98.61 C \\\\nATOM 2783 C ILE A 355 7.110 3.408 -2.884 1.00 98.61 C \\\\nATOM 2784 CB ILE A 355 5.617 1.375 -2.426 1.00 98.61 C \\\\nATOM 2785 O ILE A 355 7.277 4.332 -2.086 1.00 98.61 O \\\\nATOM 2786 CG1 ILE A 355 4.688 2.175 -1.494 1.00 98.61 C \\\\nATOM 2787 CG2 ILE A 355 5.653 -0.123 -2.075 1.00 98.61 C \\\\nATOM 2788 CD1 ILE A 355 3.241 1.685 -1.442 1.00 98.61 C \\\\nATOM 2789 N PHE A 356 6.994 3.616 -4.188 1.00 98.53 N \\\\nATOM 2790 CA PHE A 356 7.125 4.925 -4.823 1.00 98.53 C \\\\nATOM 2791 C PHE A 356 5.921 5.140 -5.721 1.00 98.53 C \\\\nATOM 2792 CB PHE A 356 8.440 4.970 -5.608 1.00 98.53 C \\\\nATOM 2793 O PHE A 356 5.652 4.287 -6.556 1.00 98.53 O \\\\nATOM 2794 CG PHE A 356 9.661 4.735 -4.752 1.00 98.53 C \\\\nATOM 2795 CD1 PHE A 356 10.376 5.816 -4.206 1.00 98.53 C \\\\nATOM 2796 CD2 PHE A 356 10.061 3.416 -4.470 1.00 98.53 C \\\\nATOM 2797 CE1 PHE A 356 11.488 5.562 -3.384 1.00 98.53 C \\\\nATOM 2798 CE2 PHE A 356 11.152 3.175 -3.623 1.00 98.53 C \\\\nATOM 2799 CZ PHE A 356 11.881 4.248 -3.096 1.00 98.53 C \\\\nATOM 2800 N VAL A 357 5.184 6.229 -5.533 1.00 98.21 N \\\\nATOM 2801 CA VAL A 357 3.879 6.458 -6.159 1.00 98.21 C \\\\nATOM 2802 C VAL A 357 3.912 7.739 -6.975 1.00 98.21 C \\\\nATOM 2803 CB VAL A 357 2.761 6.519 -5.101 1.00 98.21 C \\\\nATOM 2804 O VAL A 357 4.269 8.792 -6.458 1.00 98.21 O \\\\nATOM 2805 CG1 VAL A 357 1.389 6.733 -5.755 1.00 98.21 C \\\\nATOM 2806 CG2 VAL A 357 2.726 5.232 -4.262 1.00 98.21 C \\\\nATOM 2807 N GLN A 358 3.482 7.661 -8.228 1.00 98.17 N \\\\nATOM 2808 CA GLN A 358 3.169 8.813 -9.064 1.00 98.17 C \\\\nATOM 2809 C GLN A 358 1.657 8.841 -9.264 1.00 98.17 C \\\\nATOM 2810 CB GLN A 358 3.941 8.699 -10.381 1.00 98.17 C \\\\nATOM 2811 O GLN A 358 1.110 8.033 -10.017 1.00 98.17 O \\\\nATOM 2812 CG GLN A 358 3.722 9.881 -11.334 1.00 98.17 C \\\\nATOM 2813 CD GLN A 358 4.458 9.662 -12.654 1.00 98.17 C \\\\nATOM 2814 NE2 GLN A 358 5.532 10.379 -12.912 1.00 98.17 N \\\\nATOM 2815 OE1 GLN A 358 4.105 8.810 -13.458 1.00 98.17 O \\\\nATOM 2816 N SER A 359 0.989 9.755 -8.561 1.00 97.96 N \\\\nATOM 2817 CA SER A 359 -0.434 10.039 -8.743 1.00 97.96 C \\\\nATOM 2818 C SER A 359 -0.601 11.513 -9.107 1.00 97.96 C \\\\nATOM 2819 CB SER A 359 -1.239 9.712 -7.487 1.00 97.96 C \\\\nATOM 2820 O SER A 359 -0.374 12.367 -8.244 1.00 97.96 O \\\\nATOM 2821 OG SER A 359 -2.534 10.252 -7.659 1.00 97.96 O \\\\nATOM 2822 N PRO A 360 -1.021 11.832 -10.342 1.00 97.02 N \\\\nATOM 2823 CA PRO A 360 -1.266 13.212 -10.746 1.00 97.02 C \\\\nATOM 2824 C PRO A 360 -2.301 13.928 -9.861 1.00 97.02 C \\\\nATOM 2825 CB PRO A 360 -1.701 13.112 -12.207 1.00 97.02 C \\\\nATOM 2826 O PRO A 360 -2.092 15.082 -9.499 1.00 97.02 O \\\\nATOM 2827 CG PRO A 360 -0.983 11.862 -12.707 1.00 97.02 C \\\\nATOM 2828 CD PRO A 360 -1.102 10.942 -11.498 1.00 97.02 C \\\\nATOM 2829 N ASN A 361 -3.351 13.228 -9.408 1.00 97.36 N \\\\nATOM 2830 CA ASN A 361 -4.341 13.769 -8.464 1.00 97.36 C \\\\nATOM 2831 C ASN A 361 -3.713 14.156 -7.117 1.00 97.36 C \\\\nATOM 2832 CB ASN A 361 -5.472 12.738 -8.310 1.00 97.36 C \\\\nATOM 2833 O ASN A 361 -3.924 15.261 -6.622 1.00 97.36 O \\\\nATOM 2834 CG ASN A 361 -6.573 13.205 -7.372 1.00 97.36 C \\\\nATOM 2835 ND2 ASN A 361 -7.574 13.894 -7.865 1.00 97.36 N \\\\nATOM 2836 OD1 ASN A 361 -6.548 12.926 -6.183 1.00 97.36 O \\\\nATOM 2837 N CYS A 362 -2.876 13.280 -6.556 1.00 96.14 N \\\\nATOM 2838 CA CYS A 362 -2.138 13.572 -5.328 1.00 96.14 C \\\\nATOM 2839 C CYS A 362 -1.158 14.740 -5.520 1.00 96.14 C \\\\nATOM 2840 CB CYS A 362 -1.401 12.295 -4.912 1.00 96.14 C \\\\nATOM 2841 O CYS A 362 -1.072 15.621 -4.668 1.00 96.14 O \\\\nATOM 2842 SG CYS A 362 -0.540 12.518 -3.334 1.00 96.14 S \\\\nATOM 2843 N ASN A 363 -0.430 14.758 -6.637 1.00 96.49 N \\\\nATOM 2844 CA ASN A 363 0.555 15.793 -6.934 1.00 96.49 C \\\\nATOM 2845 C ASN A 363 -0.107 17.169 -7.060 1.00 96.49 C \\\\nATOM 2846 CB ASN A 363 1.332 15.387 -8.199 1.00 96.49 C \\\\nATOM 2847 O ASN A 363 0.365 18.123 -6.448 1.00 96.49 O \\\\nATOM 2848 CG ASN A 363 2.246 14.195 -7.964 1.00 96.49 C \\\\nATOM 2849 ND2 ASN A 363 2.709 13.537 -8.998 1.00 96.49 N \\\\nATOM 2850 OD1 ASN A 363 2.590 13.845 -6.847 1.00 96.49 O \\\\nATOM 2851 N GLN A 364 -1.248 17.251 -7.749 1.00 95.57 N \\\\nATOM 2852 CA GLN A 364 -2.022 18.483 -7.863 1.00 95.57 C \\\\nATOM 2853 C GLN A 364 -2.529 18.980 -6.503 1.00 95.57 C \\\\nATOM 2854 CB GLN A 364 -3.164 18.253 -8.857 1.00 95.57 C \\\\nATOM 2855 O GLN A 364 -2.400 20.168 -6.215 1.00 95.57 O \\\\nATOM 2856 CG GLN A 364 -3.989 19.528 -9.096 1.00 95.57 C \\\\nATOM 2857 CD GLN A 364 -4.957 19.385 -10.265 1.00 95.57 C \\\\nATOM 2858 NE2 GLN A 364 -5.916 20.272 -10.402 1.00 95.57 N \\\\nATOM 2859 OE1 GLN A 364 -4.870 18.483 -11.078 1.00 95.57 O \\\\nATOM 2860 N ARG A 365 -3.030 18.089 -5.632 1.00 95.41 N \\\\nATOM 2861 CA ARG A 365 -3.483 18.449 -4.273 1.00 95.41 C \\\\nATOM 2862 C ARG A 365 -2.396 19.155 -3.458 1.00 95.41 C \\\\nATOM 2863 CB ARG A 365 -3.955 17.182 -3.540 1.00 95.41 C \\\\nATOM 2864 O ARG A 365 -2.692 20.091 -2.721 1.00 95.41 O \\\\nATOM 2865 CG ARG A 365 -4.554 17.483 -2.151 1.00 95.41 C \\\\nATOM 2866 CD ARG A 365 -4.732 16.213 -1.315 1.00 95.41 C \\\\nATOM 2867 NE ARG A 365 -5.657 15.286 -1.972 1.00 95.41 N \\\\nATOM 2868 NH1 ARG A 365 -4.525 13.324 -1.744 1.00 95.41 N \\\\nATOM 2869 NH2 ARG A 365 -6.301 13.471 -3.120 1.00 95.41 N \\\\nATOM 2870 CZ ARG A 365 -5.495 14.021 -2.269 1.00 95.41 C \\\\nATOM 2871 N TYR A 366 -1.151 18.699 -3.571 1.00 94.64 N \\\\nATOM 2872 CA TYR A 366 -0.016 19.262 -2.833 1.00 94.64 C \\\\nATOM 2873 C TYR A 366 0.746 20.354 -3.601 1.00 94.64 C \\\\nATOM 2874 CB TYR A 366 0.897 18.124 -2.357 1.00 94.64 C \\\\nATOM 2875 O TYR A 366 1.752 20.850 -3.098 1.00 94.64 O \\\\nATOM 2876 CG TYR A 366 0.253 17.198 -1.339 1.00 94.64 C \\\\nATOM 2877 CD1 TYR A 366 -0.097 17.689 -0.066 1.00 94.64 C \\\\nATOM 2878 CD2 TYR A 366 0.010 15.849 -1.656 1.00 94.64 C \\\\nATOM 2879 CE1 TYR A 366 -0.699 16.839 0.883 1.00 94.64 C \\\\nATOM 2880 CE2 TYR A 366 -0.598 14.996 -0.716 1.00 94.64 C \\\\nATOM 2881 OH TYR A 366 -1.546 14.667 1.459 1.00 94.64 O \\\\nATOM 2882 CZ TYR A 366 -0.953 15.490 0.554 1.00 94.64 C \\\\nATOM 2883 N GLY A 367 0.293 20.740 -4.800 1.00 95.30 N \\\\nATOM 2884 CA GLY A 367 0.976 21.736 -5.634 1.00 95.30 C \\\\nATOM 2885 C GLY A 367 2.334 21.268 -6.168 1.00 95.30 C \\\\nATOM 2886 O GLY A 367 3.211 22.085 -6.441 1.00 95.30 O \\\\nATOM 2887 N TRP A 368 2.542 19.957 -6.288 1.00 95.17 N \\\\nATOM 2888 CA TRP A 368 3.743 19.377 -6.881 1.00 95.17 C \\\\nATOM 2889 C TRP A 368 3.590 19.216 -8.391 1.00 95.17 C \\\\nATOM 2890 CB TRP A 368 4.063 18.034 -6.218 1.00 95.17 C \\\\nATOM 2891 O TRP A 368 2.484 19.074 -8.910 1.00 95.17 O \\\\nATOM 2892 CG TRP A 368 4.353 18.072 -4.751 1.00 95.17 C \\\\nATOM 2893 CD1 TRP A 368 4.860 19.125 -4.069 1.00 95.17 C \\\\nATOM 2894 CD2 TRP A 368 4.110 17.033 -3.755 1.00 95.17 C \\\\nATOM 2895 CE2 TRP A 368 4.511 17.533 -2.480 1.00 95.17 C \\\\nATOM 2896 CE3 TRP A 368 3.550 15.737 -3.790 1.00 95.17 C \\\\nATOM 2897 NE1 TRP A 368 4.962 18.809 -2.732 1.00 95.17 N \\\\nATOM 2898 CH2 TRP A 368 3.799 15.509 -1.367 1.00 95.17 C \\\\nATOM 2899 CZ2 TRP A 368 4.378 16.786 -1.301 1.00 95.17 C \\\\nATOM 2900 CZ3 TRP A 368 3.374 14.997 -2.605 1.00 95.17 C \\\\nATOM 2901 N HIS A 369 4.722 19.151 -9.096 1.00 95.30 N \\\\nATOM 2902 CA HIS A 369 4.724 18.820 -10.518 1.00 95.30 C \\\\nATOM 2903 C HIS A 369 3.951 17.502 -10.767 1.00 95.30 C \\\\nATOM 2904 CB HIS A 369 6.175 18.730 -11.012 1.00 95.30 C \\\\nATOM 2905 O HIS A 369 4.157 16.543 -10.016 1.00 95.30 O \\\\nATOM 2906 CG HIS A 369 6.259 18.606 -12.508 1.00 95.30 C \\\\nATOM 2907 CD2 HIS A 369 6.255 19.634 -13.411 1.00 95.30 C \\\\nATOM 2908 ND1 HIS A 369 6.303 17.435 -13.227 1.00 95.30 N \\\\nATOM 2909 CE1 HIS A 369 6.308 17.747 -14.536 1.00 95.30 C \\\\nATOM 2910 NE2 HIS A 369 6.277 19.073 -14.687 1.00 95.30 N \\\\nATOM 2911 N PRO A 370 3.101 17.384 -11.811 1.00 93.40 N \\\\nATOM 2912 CA PRO A 370 2.279 16.186 -12.047 1.00 93.40 C \\\\nATOM 2913 C PRO A 370 3.077 14.876 -12.133 1.00 93.40 C \\\\nATOM 2914 CB PRO A 370 1.543 16.461 -13.362 1.00 93.40 C \\\\nATOM 2915 O PRO A 370 2.563 13.802 -11.826 1.00 93.40 O \\\\nATOM 2916 CG PRO A 370 1.414 17.981 -13.379 1.00 93.40 C \\\\nATOM 2917 CD PRO A 370 2.718 18.445 -12.736 1.00 93.40 C \\\\nATOM 2918 N ALA A 371 4.357 14.974 -12.496 1.00 94.38 N \\\\nATOM 2919 CA ALA A 371 5.297 13.861 -12.604 1.00 94.38 C \\\\nATOM 2920 C ALA A 371 5.973 13.426 -11.297 1.00 94.38 C \\\\nATOM 2921 CB ALA A 371 6.387 14.274 -13.578 1.00 94.38 C \\\\nATOM 2922 O ALA A 371 6.759 12.473 -11.329 1.00 94.38 O \\\\nATOM 2923 N THR A 372 5.744 14.139 -10.194 1.00 95.75 N \\\\nATOM 2924 CA THR A 372 6.399 13.888 -8.909 1.00 95.75 C \\\\nATOM 2925 C THR A 372 6.146 12.462 -8.433 1.00 95.75 C \\\\nATOM 2926 CB THR A 372 5.952 14.920 -7.865 1.00 95.75 C \\\\nATOM 2927 O THR A 372 5.046 11.922 -8.567 1.00 95.75 O \\\\nATOM 2928 CG2 THR A 372 6.466 14.662 -6.449 1.00 95.75 C \\\\nATOM 2929 OG1 THR A 372 6.486 16.161 -8.254 1.00 95.75 O \\\\nATOM 2930 N VAL A 373 7.196 11.851 -7.883 1.00 97.76 N \\\\nATOM 2931 CA VAL A 373 7.174 10.489 -7.352 1.00 97.76 C \\\\nATOM 2932 C VAL A 373 7.317 10.554 -5.835 1.00 97.76 C \\\\nATOM 2933 CB VAL A 373 8.270 9.626 -7.999 1.00 97.76 C \\\\nATOM 2934 O VAL A 373 8.382 10.863 -5.303 1.00 97.76 O \\\\nATOM 2935 CG1 VAL A 373 8.211 8.193 -7.461 1.00 97.76 C \\\\nATOM 2936 CG2 VAL A 373 8.108 9.574 -9.523 1.00 97.76 C \\\\nATOM 2937 N CYS A 374 6.238 10.243 -5.128 1.00 96.60 N \\\\nATOM 2938 CA CYS A 374 6.176 10.254 -3.674 1.00 96.60 C \\\\nATOM 2939 C CYS A 374 6.661 8.916 -3.110 1.00 96.60 C \\\\nATOM 2940 CB CYS A 374 4.736 10.540 -3.234 1.00 96.60 C \\\\nATOM 2941 O CYS A 374 6.140 7.856 -3.455 1.00 96.60 O \\\\nATOM 2942 SG CYS A 374 4.133 12.066 -4.000 1.00 96.60 S \\\\nATOM 2943 N LYS A 375 7.632 8.944 -2.196 1.00 97.82 N \\\\nATOM 2944 CA LYS A 375 8.061 7.751 -1.455 1.00 97.82 C \\\\nATOM 2945 C LYS A 375 7.115 7.495 -0.279 1.00 97.82 C \\\\nATOM 2946 CB LYS A 375 9.514 7.947 -1.006 1.00 97.82 C \\\\nATOM 2947 O LYS A 375 6.924 8.382 0.546 1.00 97.82 O \\\\nATOM 2948 CG LYS A 375 10.077 6.726 -0.267 1.00 97.82 C \\\\nATOM 2949 CD LYS A 375 11.522 7.007 0.156 1.00 97.82 C \\\\nATOM 2950 CE LYS A 375 12.114 5.801 0.888 1.00 97.82 C \\\\nATOM 2951 NZ LYS A 375 13.500 6.086 1.337 1.00 97.82 N \\\\nATOM 2952 N ILE A 376 6.602 6.272 -0.154 1.00 97.37 N \\\\nATOM 2953 CA ILE A 376 5.853 5.795 1.017 1.00 97.37 C \\\\nATOM 2954 C ILE A 376 6.740 4.781 1.759 1.00 97.37 C \\\\nATOM 2955 CB ILE A 376 4.485 5.196 0.624 1.00 97.37 C \\\\nATOM 2956 O ILE A 376 6.971 3.680 1.248 1.00 97.37 O \\\\nATOM 2957 CG1 ILE A 376 3.673 6.151 -0.281 1.00 97.37 C \\\\nATOM 2958 CG2 ILE A 376 3.690 4.828 1.893 1.00 97.37 C \\\\nATOM 2959 CD1 ILE A 376 2.346 5.562 -0.771 1.00 97.37 C \\\\nATOM 2960 N PRO A 377 7.299 5.143 2.929 1.00 97.58 N \\\\nATOM 2961 CA PRO A 377 8.103 4.230 3.740 1.00 97.58 C \\\\nATOM 2962 C PRO A 377 7.293 3.046 4.303 1.00 97.58 C \\\\nATOM 2963 CB PRO A 377 8.691 5.083 4.871 1.00 97.58 C \\\\nATOM 2964 O PRO A 377 6.067 3.136 4.395 1.00 97.58 O \\\\nATOM 2965 CG PRO A 377 8.623 6.511 4.334 1.00 97.58 C \\\\nATOM 2966 CD PRO A 377 7.356 6.487 3.489 1.00 97.58 C \\\\nATOM 2967 N PRO A 378 7.964 1.961 4.737 1.00 97.58 N \\\\nATOM 2968 CA PRO A 378 7.325 0.838 5.428 1.00 97.58 C \\\\nATOM 2969 C PRO A 378 6.428 1.283 6.590 1.00 97.58 C \\\\nATOM 2970 CB PRO A 378 8.480 -0.034 5.930 1.00 97.58 C \\\\nATOM 2971 O PRO A 378 6.843 2.075 7.434 1.00 97.58 O \\\\nATOM 2972 CG PRO A 378 9.568 0.224 4.894 1.00 97.58 C \\\\nATOM 2973 CD PRO A 378 9.391 1.707 4.591 1.00 97.58 C \\\\nATOM 2974 N GLY A 379 5.193 0.777 6.633 1.00 92.70 N \\\\nATOM 2975 CA GLY A 379 4.200 1.105 7.662 1.00 92.70 C \\\\nATOM 2976 C GLY A 379 3.500 2.459 7.491 1.00 92.70 C \\\\nATOM 2977 O GLY A 379 2.587 2.768 8.258 1.00 92.70 O \\\\nATOM 2978 N CYS A 380 3.885 3.268 6.500 1.00 95.04 N \\\\nATOM 2979 CA CYS A 380 3.205 4.520 6.177 1.00 95.04 C \\\\nATOM 2980 C CYS A 380 2.071 4.305 5.165 1.00 95.04 C \\\\nATOM 2981 CB CYS A 380 4.220 5.558 5.676 1.00 95.04 C \\\\nATOM 2982 O CYS A 380 2.049 3.328 4.415 1.00 95.04 O \\\\nATOM 2983 SG CYS A 380 5.459 5.922 6.954 1.00 95.04 S \\\\nATOM 2984 N ASN A 381 1.143 5.261 5.116 1.00 94.89 N \\\\nATOM 2985 CA ASN A 381 0.094 5.328 4.105 1.00 94.89 C \\\\nATOM 2986 C ASN A 381 0.009 6.730 3.486 1.00 94.89 C \\\\nATOM 2987 CB ASN A 381 -1.248 4.848 4.687 1.00 94.89 C \\\\nATOM 2988 O ASN A 381 0.466 7.703 4.085 1.00 94.89 O \\\\nATOM 2989 CG ASN A 381 -1.764 5.753 5.791 1.00 94.89 C \\\\nATOM 2990 ND2 ASN A 381 -1.454 5.453 7.031 1.00 94.89 N \\\\nATOM 2991 OD1 ASN A 381 -2.427 6.748 5.560 1.00 94.89 O \\\\nATOM 2992 N LEU A 382 -0.562 6.818 2.286 1.00 94.95 N \\\\nATOM 2993 CA LEU A 382 -0.778 8.062 1.549 1.00 94.95 C \\\\nATOM 2994 C LEU A 382 -2.145 8.028 0.863 1.00 94.95 C \\\\nATOM 2995 CB LEU A 382 0.357 8.226 0.521 1.00 94.95 C \\\\nATOM 2996 O LEU A 382 -2.516 7.012 0.275 1.00 94.95 O \\\\nATOM 2997 CG LEU A 382 0.314 9.514 -0.324 1.00 94.95 C \\\\nATOM 2998 CD1 LEU A 382 0.495 10.768 0.533 1.00 94.95 C \\\\nATOM 2999 CD2 LEU A 382 1.430 9.477 -1.368 1.00 94.95 C \\\\nATOM 3000 N LYS A 383 -2.872 9.150 0.889 1.00 96.88 N \\\\nATOM 3001 CA LYS A 383 -4.083 9.348 0.081 1.00 96.88 C \\\\nATOM 3002 C LYS A 383 -3.681 9.634 -1.363 1.00 96.88 C \\\\nATOM 3003 CB LYS A 383 -4.923 10.485 0.675 1.00 96.88 C \\\\nATOM 3004 O LYS A 383 -3.294 10.754 -1.690 1.00 96.88 O \\\\nATOM 3005 CG LYS A 383 -6.269 10.625 -0.058 1.00 96.88 C \\\\nATOM 3006 CD LYS A 383 -7.087 11.818 0.451 1.00 96.88 C \\\\nATOM 3007 CE LYS A 383 -7.420 11.669 1.938 1.00 96.88 C \\\\nATOM 3008 NZ LYS A 383 -8.317 12.746 2.405 1.00 96.88 N \\\\nATOM 3009 N ILE A 384 -3.771 8.626 -2.220 1.00 97.74 N \\\\nATOM 3010 CA ILE A 384 -3.300 8.703 -3.605 1.00 97.74 C \\\\nATOM 3011 C ILE A 384 -4.361 9.256 -4.559 1.00 97.74 C \\\\nATOM 3012 CB ILE A 384 -2.738 7.347 -4.082 1.00 97.74 C \\\\nATOM 3013 O ILE A 384 -3.991 9.710 -5.633 1.00 97.74 O \\\\nATOM 3014 CG1 ILE A 384 -3.828 6.254 -4.146 1.00 97.74 C \\\\nATOM 3015 CG2 ILE A 384 -1.557 6.924 -3.190 1.00 97.74 C \\\\nATOM 3016 CD1 ILE A 384 -3.349 4.937 -4.762 1.00 97.74 C \\\\nATOM 3017 N PHE A 385 -5.646 9.255 -4.196 1.00 97.98 N \\\\nATOM 3018 CA PHE A 385 -6.714 9.810 -5.034 1.00 97.98 C \\\\nATOM 3019 C PHE A 385 -7.903 10.309 -4.205 1.00 97.98 C \\\\nATOM 3020 CB PHE A 385 -7.190 8.749 -6.032 1.00 97.98 C \\\\nATOM 3021 O PHE A 385 -8.200 9.731 -3.159 1.00 97.98 O \\\\nATOM 3022 CG PHE A 385 -7.952 9.324 -7.205 1.00 97.98 C \\\\nATOM 3023 CD1 PHE A 385 -9.359 9.385 -7.181 1.00 97.98 C \\\\nATOM 3024 CD2 PHE A 385 -7.253 9.791 -8.333 1.00 97.98 C \\\\nATOM 3025 CE1 PHE A 385 -10.052 9.907 -8.285 1.00 97.98 C \\\\nATOM 3026 CE2 PHE A 385 -7.959 10.308 -9.432 1.00 97.98 C \\\\nATOM 3027 CZ PHE A 385 -9.358 10.352 -9.416 1.00 97.98 C \\\\nATOM 3028 N ASN A 386 -8.595 11.344 -4.681 1.00 95.89 N \\\\nATOM 3029 CA ASN A 386 -9.868 11.815 -4.134 1.00 95.89 C \\\\nATOM 3030 C ASN A 386 -10.840 12.167 -5.281 1.00 95.89 C \\\\nATOM 3031 CB ASN A 386 -9.582 12.993 -3.183 1.00 95.89 C \\\\nATOM 3032 O ASN A 386 -10.531 12.988 -6.148 1.00 95.89 O \\\\nATOM 3033 CG ASN A 386 -10.836 13.650 -2.638 1.00 95.89 C \\\\nATOM 3034 ND2 ASN A 386 -11.081 13.677 -1.353 1.00 95.89 N \\\\nATOM 3035 OD1 ASN A 386 -11.657 14.142 -3.385 1.00 95.89 O \\\\nATOM 3036 N ASN A 387 -12.028 11.554 -5.262 1.00 94.32 N \\\\nATOM 3037 CA ASN A 387 -13.050 11.721 -6.296 1.00 94.32 C \\\\nATOM 3038 C ASN A 387 -13.654 13.130 -6.338 1.00 94.32 C \\\\nATOM 3039 CB ASN A 387 -14.183 10.698 -6.083 1.00 94.32 C \\\\nATOM 3040 O ASN A 387 -14.024 13.580 -7.415 1.00 94.32 O \\\\nATOM 3041 CG ASN A 387 -13.870 9.277 -6.515 1.00 94.32 C \\\\nATOM 3042 ND2 ASN A 387 -14.802 8.374 -6.338 1.00 94.32 N \\\\nATOM 3043 OD1 ASN A 387 -12.814 8.959 -7.028 1.00 94.32 O \\\\nATOM 3044 N GLN A 388 -13.768 13.834 -5.209 1.00 93.82 N \\\\nATOM 3045 CA GLN A 388 -14.294 15.206 -5.180 1.00 93.82 C \\\\nATOM 3046 C GLN A 388 -13.327 16.188 -5.848 1.00 93.82 C \\\\nATOM 3047 CB GLN A 388 -14.558 15.666 -3.740 1.00 93.82 C \\\\nATOM 3048 O GLN A 388 -13.753 17.058 -6.602 1.00 93.82 O \\\\nATOM 3049 CG GLN A 388 -15.637 14.855 -3.015 1.00 93.82 C \\\\nATOM 3050 CD GLN A 388 -15.860 15.367 -1.596 1.00 93.82 C \\\\nATOM 3051 NE2 GLN A 388 -17.079 15.365 -1.111 1.00 93.82 N \\\\nATOM 3052 OE1 GLN A 388 -14.960 15.786 -0.891 1.00 93.82 O \\\\nATOM 3053 N GLU A 389 -12.024 16.024 -5.615 1.00 94.83 N \\\\nATOM 3054 CA GLU A 389 -10.987 16.821 -6.276 1.00 94.83 C \\\\nATOM 3055 C GLU A 389 -10.980 16.567 -7.786 1.00 94.83 C \\\\nATOM 3056 CB GLU A 389 -9.615 16.480 -5.684 1.00 94.83 C \\\\nATOM 3057 O GLU A 389 -10.916 17.509 -8.573 1.00 94.83 O \\\\nATOM 3058 CG GLU A 389 -9.465 16.962 -4.234 1.00 94.83 C \\\\nATOM 3059 CD GLU A 389 -8.200 16.419 -3.565 1.00 94.83 C \\\\nATOM 3060 OE1 GLU A 389 -8.029 16.604 -2.342 1.00 94.83 O \\\\nATOM 3061 OE2 GLU A 389 -7.391 15.714 -4.210 1.00 94.83 O \\\\nATOM 3062 N PHE A 390 -11.113 15.301 -8.197 1.00 96.24 N \\\\nATOM 3063 CA PHE A 390 -11.250 14.953 -9.609 1.00 96.24 C \\\\nATOM 3064 C PHE A 390 -12.540 15.514 -10.225 1.00 96.24 C \\\\nATOM 3065 CB PHE A 390 -11.166 13.434 -9.773 1.00 96.24 C \\\\nATOM 3066 O PHE A 390 -12.490 16.068 -11.317 1.00 96.24 O \\\\nATOM 3067 CG PHE A 390 -11.298 12.992 -11.217 1.00 96.24 C \\\\nATOM 3068 CD1 PHE A 390 -12.518 12.467 -11.688 1.00 96.24 C \\\\nATOM 3069 CD2 PHE A 390 -10.216 13.152 -12.103 1.00 96.24 C \\\\nATOM 3070 CE1 PHE A 390 -12.650 12.096 -13.038 1.00 96.24 C \\\\nATOM 3071 CE2 PHE A 390 -10.352 12.779 -13.452 1.00 96.24 C \\\\nATOM 3072 CZ PHE A 390 -11.566 12.248 -13.917 1.00 96.24 C \\\\nATOM 3073 N ALA A 391 -13.674 15.437 -9.519 1.00 94.09 N \\\\nATOM 3074 CA ALA A 391 -14.953 15.999 -9.956 1.00 94.09 C \\\\nATOM 3075 C ALA A 391 -14.858 17.504 -10.230 1.00 94.09 C \\\\nATOM 3076 CB ALA A 391 -15.999 15.773 -8.856 1.00 94.09 C \\\\nATOM 3077 O ALA A 391 -15.314 17.984 -11.267 1.00 94.09 O \\\\nATOM 3078 N ALA A 392 -14.256 18.246 -9.295 1.00 94.21 N \\\\nATOM 3079 CA ALA A 392 -14.075 19.686 -9.418 1.00 94.21 C \\\\nATOM 3080 C ALA A 392 -13.184 20.033 -10.617 1.00 94.21 C \\\\nATOM 3081 CB ALA A 392 -13.490 20.214 -8.103 1.00 94.21 C \\\\nATOM 3082 O ALA A 392 -13.516 20.936 -11.383 1.00 94.21 O \\\\nATOM 3083 N LEU A 393 -12.094 19.286 -10.811 1.00 94.52 N \\\\nATOM 3084 CA LEU A 393 -11.209 19.462 -11.958 1.00 94.52 C \\\\nATOM 3085 C LEU A 393 -11.916 19.143 -13.280 1.00 94.52 C \\\\nATOM 3086 CB LEU A 393 -9.968 18.587 -11.751 1.00 94.52 C \\\\nATOM 3087 O LEU A 393 -11.835 19.930 -14.214 1.00 94.52 O \\\\nATOM 3088 CG LEU A 393 -8.927 18.738 -12.870 1.00 94.52 C \\\\nATOM 3089 CD1 LEU A 393 -8.401 20.170 -12.984 1.00 94.52 C \\\\nATOM 3090 CD2 LEU A 393 -7.771 17.797 -12.558 1.00 94.52 C \\\\nATOM 3091 N LEU A 394 -12.662 18.038 -13.344 1.00 94.94 N \\\\nATOM 3092 CA LEU A 394 -13.439 17.651 -14.520 1.00 94.94 C \\\\nATOM 3093 C LEU A 394 -14.450 18.735 -14.906 1.00 94.94 C \\\\nATOM 3094 CB LEU A 394 -14.099 16.288 -14.237 1.00 94.94 C \\\\nATOM 3095 O LEU A 394 -14.493 19.146 -16.063 1.00 94.94 O \\\\nATOM 3096 CG LEU A 394 -14.979 15.742 -15.376 1.00 94.94 C \\\\nATOM 3097 CD1 LEU A 394 -14.211 15.600 -16.687 1.00 94.94 C \\\\nATOM 3098 CD2 LEU A 394 -15.510 14.362 -14.978 1.00 94.94 C \\\\nATOM 3099 N ALA A 395 -15.207 19.256 -13.937 1.00 93.07 N \\\\nATOM 3100 CA ALA A 395 -16.156 20.342 -14.169 1.00 93.07 C \\\\nATOM 3101 C ALA A 395 -15.480 21.632 -14.670 1.00 93.07 C \\\\nATOM 3102 CB ALA A 395 -16.929 20.587 -12.868 1.00 93.07 C \\\\nATOM 3103 O ALA A 395 -16.045 22.343 -15.498 1.00 93.07 O \\\\nATOM 3104 N GLN A 396 -14.266 21.935 -14.201 1.00 93.21 N \\\\nATOM 3105 CA GLN A 396 -13.488 23.081 -14.681 1.00 93.21 C \\\\nATOM 3106 C GLN A 396 -12.965 22.861 -16.107 1.00 93.21 C \\\\nATOM 3107 CB GLN A 396 -12.330 23.364 -13.715 1.00 93.21 C \\\\nATOM 3108 O GLN A 396 -13.097 23.755 -16.943 1.00 93.21 O \\\\nATOM 3109 CG GLN A 396 -12.817 23.965 -12.389 1.00 93.21 C \\\\nATOM 3110 CD GLN A 396 -11.714 24.049 -11.337 1.00 93.21 C \\\\nATOM 3111 NE2 GLN A 396 -12.058 24.325 -10.098 1.00 93.21 N \\\\nATOM 3112 OE1 GLN A 396 -10.531 23.896 -11.587 1.00 93.21 O \\\\nATOM 3113 N SER A 397 -12.420 21.677 -16.400 1.00 93.63 N \\\\nATOM 3114 CA SER A 397 -11.832 21.340 -17.702 1.00 93.63 C \\\\nATOM 3115 C SER A 397 -12.854 21.267 -18.834 1.00 93.63 C \\\\nATOM 3116 CB SER A 397 -11.082 20.010 -17.619 1.00 93.63 C \\\\nATOM 3117 O SER A 397 -12.492 21.547 -19.971 1.00 93.63 O \\\\nATOM 3118 OG SER A 397 -9.968 20.134 -16.755 1.00 93.63 O \\\\nATOM 3119 N VAL A 398 -14.131 20.978 -18.552 1.00 91.77 N \\\\nATOM 3120 CA VAL A 398 -15.205 21.048 -19.564 1.00 91.77 C \\\\nATOM 3121 C VAL A 398 -15.265 22.425 -20.234 1.00 91.77 C \\\\nATOM 3122 CB VAL A 398 -16.559 20.665 -18.938 1.00 91.77 C \\\\nATOM 3123 O VAL A 398 -15.428 22.509 -21.448 1.00 91.77 O \\\\nATOM 3124 CG1 VAL A 398 -17.769 21.034 -19.801 1.00 91.77 C \\\\nATOM 3125 CG2 VAL A 398 -16.616 19.149 -18.736 1.00 91.77 C \\\\nATOM 3126 N ASN A 399 -15.031 23.506 -19.484 1.00 88.71 N \\\\nATOM 3127 CA ASN A 399 -15.034 24.867 -20.034 1.00 88.71 C \\\\nATOM 3128 C ASN A 399 -13.769 25.208 -20.843 1.00 88.71 C \\\\nATOM 3129 CB ASN A 399 -15.237 25.870 -18.890 1.00 88.71 C \\\\nATOM 3130 O ASN A 399 -13.734 26.231 -21.518 1.00 88.71 O \\\\nATOM 3131 CG ASN A 399 -16.513 25.607 -18.116 1.00 88.71 C \\\\nATOM 3132 ND2 ASN A 399 -16.405 25.322 -16.841 1.00 88.71 N \\\\nATOM 3133 OD1 ASN A 399 -17.610 25.615 -18.643 1.00 88.71 O \\\\nATOM 3134 N GLN A 400 -12.726 24.377 -20.767 1.00 90.24 N \\\\nATOM 3135 CA GLN A 400 -11.464 24.554 -21.497 1.00 90.24 C \\\\nATOM 3136 C GLN A 400 -11.454 23.802 -22.840 1.00 90.24 C \\\\nATOM 3137 CB GLN A 400 -10.297 24.102 -20.607 1.00 90.24 C \\\\nATOM 3138 O GLN A 400 -10.539 23.982 -23.641 1.00 90.24 O \\\\nATOM 3139 CG GLN A 400 -10.160 24.910 -19.309 1.00 90.24 C \\\\nATOM 3140 CD GLN A 400 -9.090 24.349 -18.376 1.00 90.24 C \\\\nATOM 3141 NE2 GLN A 400 -8.996 24.853 -17.167 1.00 90.24 N \\\\nATOM 3142 OE1 GLN A 400 -8.341 23.435 -18.680 1.00 90.24 O \\\\nATOM 3143 N GLY A 401 -12.472 22.976 -23.102 1.00 89.27 N \\\\nATOM 3144 CA GLY A 401 -12.641 22.243 -24.353 1.00 89.27 C \\\\nATOM 3145 C GLY A 401 -12.207 20.776 -24.292 1.00 89.27 C \\\\nATOM 3146 O GLY A 401 -11.748 20.264 -23.271 1.00 89.27 O \\\\nATOM 3147 N PHE A 402 -12.382 20.086 -25.421 1.00 90.38 N \\\\nATOM 3148 CA PHE A 402 -12.212 18.635 -25.535 1.00 90.38 C \\\\nATOM 3149 C PHE A 402 -10.825 18.148 -25.092 1.00 90.38 C \\\\nATOM 3150 CB PHE A 402 -12.499 18.227 -26.989 1.00 90.38 C \\\\nATOM 3151 O PHE A 402 -10.730 17.192 -24.327 1.00 90.38 O \\\\nATOM 3152 CG PHE A 402 -12.438 16.732 -27.227 1.00 90.38 C \\\\nATOM 3153 CD1 PHE A 402 -11.204 16.100 -27.479 1.00 90.38 C \\\\nATOM 3154 CD2 PHE A 402 -13.615 15.964 -27.177 1.00 90.38 C \\\\nATOM 3155 CE1 PHE A 402 -11.148 14.707 -27.666 1.00 90.38 C \\\\nATOM 3156 CE2 PHE A 402 -13.560 14.573 -27.372 1.00 90.38 C \\\\nATOM 3157 CZ PHE A 402 -12.327 13.944 -27.616 1.00 90.38 C \\\\nATOM 3158 N GLU A 403 -9.752 18.816 -25.531 1.00 91.17 N \\\\nATOM 3159 CA GLU A 403 -8.376 18.393 -25.238 1.00 91.17 C \\\\nATOM 3160 C GLU A 403 -8.076 18.432 -23.734 1.00 91.17 C \\\\nATOM 3161 CB GLU A 403 -7.395 19.281 -26.026 1.00 91.17 C \\\\nATOM 3162 O GLU A 403 -7.521 17.483 -23.187 1.00 91.17 O \\\\nATOM 3163 CG GLU A 403 -5.925 18.840 -25.911 1.00 91.17 C \\\\nATOM 3164 CD GLU A 403 -5.677 17.399 -26.387 1.00 91.17 C \\\\nATOM 3165 OE1 GLU A 403 -4.748 16.760 -25.836 1.00 91.17 O \\\\nATOM 3166 OE2 GLU A 403 -6.428 16.933 -27.273 1.00 91.17 O \\\\nATOM 3167 N ALA A 404 -8.515 19.483 -23.035 1.00 92.62 N \\\\nATOM 3168 CA ALA A 404 -8.321 19.609 -21.593 1.00 92.62 C \\\\nATOM 3169 C ALA A 404 -9.007 18.472 -20.823 1.00 92.62 C \\\\nATOM 3170 CB ALA A 404 -8.858 20.971 -21.154 1.00 92.62 C \\\\nATOM 3171 O ALA A 404 -8.413 17.896 -19.912 1.00 92.62 O \\\\nATOM 3172 N VAL A 405 -10.231 18.107 -21.221 1.00 93.34 N \\\\nATOM 3173 CA VAL A 405 -10.944 16.953 -20.659 1.00 93.34 C \\\\nATOM 3174 C VAL A 405 -10.209 15.657 -21.007 1.00 93.34 C \\\\nATOM 3175 CB VAL A 405 -12.409 16.916 -21.137 1.00 93.34 C \\\\nATOM 3176 O VAL A 405 -9.949 14.849 -20.123 1.00 93.34 O \\\\nATOM 3177 CG1 VAL A 405 -13.168 15.723 -20.550 1.00 93.34 C \\\\nATOM 3178 CG2 VAL A 405 -13.171 18.174 -20.705 1.00 93.34 C \\\\nATOM 3179 N TYR A 406 -9.798 15.465 -22.260 1.00 92.37 N \\\\nATOM 3180 CA TYR A 406 -9.100 14.254 -22.696 1.00 92.37 C \\\\nATOM 3181 C TYR A 406 -7.802 14.006 -21.904 1.00 92.37 C \\\\nATOM 3182 CB TYR A 406 -8.839 14.353 -24.203 1.00 92.37 C \\\\nATOM 3183 O TYR A 406 -7.530 12.876 -21.483 1.00 92.37 O \\\\nATOM 3184 CG TYR A 406 -8.253 13.085 -24.782 1.00 92.37 C \\\\nATOM 3185 CD1 TYR A 406 -6.866 12.983 -24.999 1.00 92.37 C \\\\nATOM 3186 CD2 TYR A 406 -9.099 12.000 -25.083 1.00 92.37 C \\\\nATOM 3187 CE1 TYR A 406 -6.320 11.791 -25.513 1.00 92.37 C \\\\nATOM 3188 CE2 TYR A 406 -8.557 10.807 -25.597 1.00 92.37 C \\\\nATOM 3189 OH TYR A 406 -6.648 9.555 -26.324 1.00 92.37 O \\\\nATOM 3190 CZ TYR A 406 -7.168 10.702 -25.813 1.00 92.37 C \\\\nATOM 3191 N GLN A 407 -7.043 15.062 -21.594 1.00 92.56 N \\\\nATOM 3192 CA GLN A 407 -5.833 14.987 -20.766 1.00 92.56 C \\\\nATOM 3193 C GLN A 407 -6.097 14.491 -19.332 1.00 92.56 C \\\\nATOM 3194 CB GLN A 407 -5.140 16.361 -20.741 1.00 92.56 C \\\\nATOM 3195 O GLN A 407 -5.215 13.866 -18.729 1.00 92.56 O \\\\nATOM 3196 CG GLN A 407 -4.521 16.759 -22.093 1.00 92.56 C \\\\nATOM 3197 CD GLN A 407 -3.387 15.857 -22.554 1.00 92.56 C \\\\nATOM 3198 NE2 GLN A 407 -3.095 15.834 -23.833 1.00 92.56 N \\\\nATOM 3199 OE1 GLN A 407 -2.752 15.147 -21.784 1.00 92.56 O \\\\nATOM 3200 N LEU A 408 -7.314 14.661 -18.794 1.00 94.48 N \\\\nATOM 3201 CA LEU A 408 -7.694 14.129 -17.477 1.00 94.48 C \\\\nATOM 3202 C LEU A 408 -7.704 12.599 -17.416 1.00 94.48 C \\\\nATOM 3203 CB LEU A 408 -9.060 14.664 -17.020 1.00 94.48 C \\\\nATOM 3204 O LEU A 408 -7.690 12.040 -16.318 1.00 94.48 O \\\\nATOM 3205 CG LEU A 408 -9.156 16.186 -16.858 1.00 94.48 C \\\\nATOM 3206 CD1 LEU A 408 -10.550 16.528 -16.344 1.00 94.48 C \\\\nATOM 3207 CD2 LEU A 408 -8.130 16.720 -15.861 1.00 94.48 C \\\\nATOM 3208 N THR A 409 -7.622 11.906 -18.555 1.00 94.82 N \\\\nATOM 3209 CA THR A 409 -7.381 10.454 -18.586 1.00 94.82 C \\\\nATOM 3210 C THR A 409 -6.137 10.100 -17.766 1.00 94.82 C \\\\nATOM 3211 CB THR A 409 -7.208 9.953 -20.028 1.00 94.82 C \\\\nATOM 3212 O THR A 409 -6.144 9.133 -17.007 1.00 94.82 O \\\\nATOM 3213 CG2 THR A 409 -7.149 8.427 -20.100 1.00 94.82 C \\\\nATOM 3214 OG1 THR A 409 -8.301 10.347 -20.817 1.00 94.82 O \\\\nATOM 3215 N ARG A 410 -5.094 10.946 -17.816 1.00 93.13 N \\\\nATOM 3216 CA ARG A 410 -3.854 10.766 -17.042 1.00 93.13 C \\\\nATOM 3217 C ARG A 410 -4.078 10.857 -15.534 1.00 93.13 C \\\\nATOM 3218 CB ARG A 410 -2.806 11.807 -17.467 1.00 93.13 C \\\\nATOM 3219 O ARG A 410 -3.379 10.185 -14.784 1.00 93.13 O \\\\nATOM 3220 CG ARG A 410 -2.404 11.694 -18.945 1.00 93.13 C \\\\nATOM 3221 CD ARG A 410 -1.350 12.752 -19.299 1.00 93.13 C \\\\nATOM 3222 NE ARG A 410 -0.998 12.695 -20.728 1.00 93.13 N \\\\nATOM 3223 NH1 ARG A 410 0.238 14.644 -20.846 1.00 93.13 N \\\\nATOM 3224 NH2 ARG A 410 -0.291 13.571 -22.708 1.00 93.13 N \\\\nATOM 3225 CZ ARG A 410 -0.356 13.632 -21.409 1.00 93.13 C \\\\nATOM 3226 N MET A 411 -5.054 11.647 -15.081 1.00 94.91 N \\\\nATOM 3227 CA MET A 411 -5.395 11.753 -13.657 1.00 94.91 C \\\\nATOM 3228 C MET A 411 -5.948 10.439 -13.107 1.00 94.91 C \\\\nATOM 3229 CB MET A 411 -6.416 12.876 -13.415 1.00 94.91 C \\\\nATOM 3230 O MET A 411 -5.793 10.166 -11.920 1.00 94.91 O \\\\nATOM 3231 CG MET A 411 -5.905 14.262 -13.817 1.00 94.91 C \\\\nATOM 3232 SD MET A 411 -4.534 14.885 -12.816 1.00 94.91 S \\\\nATOM 3233 CE MET A 411 -5.412 15.315 -11.297 1.00 94.91 C \\\\nATOM 3234 N CYS A 412 -6.558 9.620 -13.965 1.00 96.87 N \\\\nATOM 3235 CA CYS A 412 -7.174 8.354 -13.588 1.00 96.87 C \\\\nATOM 3236 C CYS A 412 -6.182 7.176 -13.543 1.00 96.87 C \\\\nATOM 3237 CB CYS A 412 -8.323 8.061 -14.551 1.00 96.87 C \\\\nATOM 3238 O CYS A 412 -6.571 6.071 -13.153 1.00 96.87 O \\\\nATOM 3239 SG CYS A 412 -9.484 9.454 -14.693 1.00 96.87 S \\\\nATOM 3240 N THR A 413 -4.917 7.407 -13.918 1.00 97.46 N \\\\nATOM 3241 CA THR A 413 -3.845 6.408 -13.909 1.00 97.46 C \\\\nATOM 3242 C THR A 413 -2.819 6.731 -12.826 1.00 97.46 C \\\\nATOM 3243 CB THR A 413 -3.174 6.281 -15.284 1.00 97.46 C \\\\nATOM 3244 O THR A 413 -2.224 7.807 -12.805 1.00 97.46 O \\\\nATOM 3245 CG2 THR A 413 -2.057 5.237 -15.300 1.00 97.46 C \\\\nATOM 3246 OG1 THR A 413 -4.123 5.875 -16.241 1.00 97.46 O \\\\nATOM 3247 N ILE A 414 -2.566 5.773 -11.934 1.00 98.40 N \\\\nATOM 3248 CA ILE A 414 -1.571 5.888 -10.861 1.00 98.40 C \\\\nATOM 3249 C ILE A 414 -0.518 4.805 -11.048 1.00 98.40 C \\\\nATOM 3250 CB ILE A 414 -2.229 5.818 -9.466 1.00 98.40 C \\\\nATOM 3251 O ILE A 414 -0.847 3.631 -11.200 1.00 98.40 O \\\\nATOM 3252 CG1 ILE A 414 -3.288 6.932 -9.308 1.00 98.40 C \\\\nATOM 3253 CG2 ILE A 414 -1.145 5.904 -8.372 1.00 98.40 C \\\\nATOM 3254 CD1 ILE A 414 -4.102 6.848 -8.014 1.00 98.40 C \\\\nATOM 3255 N ARG A 415 0.762 5.174 -10.987 1.00 98.53 N \\\\nATOM 3256 CA ARG A 415 1.872 4.219 -11.121 1.00 98.53 C \\\\nATOM 3257 C ARG A 415 2.588 4.041 -9.800 1.00 98.53 C \\\\nATOM 3258 CB ARG A 415 2.820 4.644 -12.244 1.00 98.53 C \\\\nATOM 3259 O ARG A 415 2.842 5.023 -9.102 1.00 98.53 O \\\\nATOM 3260 CG ARG A 415 2.070 4.671 -13.580 1.00 98.53 C \\\\nATOM 3261 CD ARG A 415 3.027 4.946 -14.731 1.00 98.53 C \\\\nATOM 3262 NE ARG A 415 2.281 4.998 -15.992 1.00 98.53 N \\\\nATOM 3263 NH1 ARG A 415 2.570 7.221 -16.554 1.00 98.53 N \\\\nATOM 3264 NH2 ARG A 415 1.353 5.820 -17.837 1.00 98.53 N \\\\nATOM 3265 CZ ARG A 415 2.087 6.027 -16.786 1.00 98.53 C \\\\nATOM 3266 N MET A 416 2.925 2.800 -9.456 1.00 98.54 N \\\\nATOM 3267 CA MET A 416 3.635 2.491 -8.216 1.00 98.54 C \\\\nATOM 3268 C MET A 416 4.779 1.514 -8.450 1.00 98.54 C \\\\nATOM 3269 CB MET A 416 2.700 1.961 -7.119 1.00 98.54 C \\\\nATOM 3270 O MET A 416 4.558 0.423 -8.959 1.00 98.54 O \\\\nATOM 3271 CG MET A 416 1.465 2.837 -6.929 1.00 98.54 C \\\\nATOM 3272 SD MET A 416 0.417 2.357 -5.534 1.00 98.54 S \\\\nATOM 3273 CE MET A 416 -1.180 2.527 -6.374 1.00 98.54 C \\\\nATOM 3274 N SER A 417 5.989 1.874 -8.031 1.00 98.68 N \\\\nATOM 3275 CA SER A 417 7.156 0.987 -8.055 1.00 98.68 C \\\\nATOM 3276 C SER A 417 7.431 0.411 -6.673 1.00 98.68 C \\\\nATOM 3277 CB SER A 417 8.388 1.709 -8.591 1.00 98.68 C \\\\nATOM 3278 O SER A 417 7.337 1.110 -5.659 1.00 98.68 O \\\\nATOM 3279 OG SER A 417 9.519 0.869 -8.532 1.00 98.68 O \\\\nATOM 3280 N PHE A 418 7.828 -0.858 -6.638 1.00 98.70 N \\\\nATOM 3281 CA PHE A 418 8.259 -1.538 -5.425 1.00 98.70 C \\\\nATOM 3282 C PHE A 418 9.772 -1.417 -5.254 1.00 98.70 C \\\\nATOM 3283 CB PHE A 418 7.837 -3.009 -5.470 1.00 98.70 C \\\\nATOM 3284 O PHE A 418 10.532 -1.666 -6.191 1.00 98.70 O \\\\nATOM 3285 CG PHE A 418 6.342 -3.225 -5.552 1.00 98.70 C \\\\nATOM 3286 CD1 PHE A 418 5.569 -3.241 -4.376 1.00 98.70 C \\\\nATOM 3287 CD2 PHE A 418 5.721 -3.406 -6.801 1.00 98.70 C \\\\nATOM 3288 CE1 PHE A 418 4.181 -3.446 -4.448 1.00 98.70 C \\\\nATOM 3289 CE2 PHE A 418 4.333 -3.607 -6.870 1.00 98.70 C \\\\nATOM 3290 CZ PHE A 418 3.561 -3.627 -5.696 1.00 98.70 C \\\\nATOM 3291 N VAL A 419 10.227 -1.120 -4.030 1.00 98.25 N \\\\nATOM 3292 CA VAL A 419 11.637 -1.131 -3.584 1.00 98.25 C \\\\nATOM 3293 C VAL A 419 12.523 -0.048 -4.215 1.00 98.25 C \\\\nATOM 3294 CB VAL A 419 12.276 -2.522 -3.799 1.00 98.25 C \\\\nATOM 3295 O VAL A 419 13.370 0.525 -3.529 1.00 98.25 O \\\\nATOM 3296 CG1 VAL A 419 13.640 -2.667 -3.112 1.00 98.25 C \\\\nATOM 3297 CG2 VAL A 419 11.402 -3.700 -3.340 1.00 98.25 C \\\\nATOM 3298 N LYS A 420 12.376 0.248 -5.511 1.00 97.93 N \\\\nATOM 3299 CA LYS A 420 13.226 1.176 -6.269 1.00 97.93 C \\\\nATOM 3300 C LYS A 420 12.432 2.405 -6.714 1.00 97.93 C \\\\nATOM 3301 CB LYS A 420 13.845 0.453 -7.483 1.00 97.93 C \\\\nATOM 3302 O LYS A 420 11.447 2.270 -7.432 1.00 97.93 O \\\\nATOM 3303 CG LYS A 420 14.640 -0.827 -7.164 1.00 97.93 C \\\\nATOM 3304 CD LYS A 420 15.786 -0.620 -6.162 1.00 97.93 C \\\\nATOM 3305 CE LYS A 420 16.542 -1.940 -5.960 1.00 97.93 C \\\\nATOM 3306 NZ LYS A 420 17.556 -1.843 -4.877 1.00 97.93 N \\\\nATOM 3307 N GLY A 421 12.905 3.593 -6.345 1.00 96.38 N \\\\nATOM 3308 CA GLY A 421 12.352 4.863 -6.819 1.00 96.38 C \\\\nATOM 3309 C GLY A 421 12.787 5.220 -8.239 1.00 96.38 C \\\\nATOM 3310 O GLY A 421 13.769 4.675 -8.761 1.00 96.38 O \\\\nATOM 3311 N TRP A 422 12.042 6.146 -8.838 1.00 98.03 N \\\\nATOM 3312 CA TRP A 422 12.339 6.792 -10.116 1.00 98.03 C \\\\nATOM 3313 C TRP A 422 11.929 8.271 -10.069 1.00 98.03 C \\\\nATOM 3314 CB TRP A 422 11.632 6.065 -11.270 1.00 98.03 C \\\\nATOM 3315 O TRP A 422 11.267 8.695 -9.122 1.00 98.03 O \\\\nATOM 3316 CG TRP A 422 10.193 6.426 -11.478 1.00 98.03 C \\\\nATOM 3317 CD1 TRP A 422 9.735 7.303 -12.401 1.00 98.03 C \\\\nATOM 3318 CD2 TRP A 422 9.016 5.985 -10.737 1.00 98.03 C \\\\nATOM 3319 CE2 TRP A 422 7.867 6.612 -11.307 1.00 98.03 C \\\\nATOM 3320 CE3 TRP A 422 8.800 5.122 -9.642 1.00 98.03 C \\\\nATOM 3321 NE1 TRP A 422 8.363 7.409 -12.311 1.00 98.03 N \\\\nATOM 3322 CH2 TRP A 422 6.387 5.528 -9.740 1.00 98.03 C \\\\nATOM 3323 CZ2 TRP A 422 6.571 6.373 -10.842 1.00 98.03 C \\\\nATOM 3324 CZ3 TRP A 422 7.500 4.913 -9.146 1.00 98.03 C \\\\nATOM 3325 N GLY A 423 12.309 9.041 -11.083 1.00 94.75 N \\\\nATOM 3326 CA GLY A 423 12.044 10.475 -11.190 1.00 94.75 C \\\\nATOM 3327 C GLY A 423 13.250 11.323 -10.786 1.00 94.75 C \\\\nATOM 3328 O GLY A 423 14.344 10.795 -10.600 1.00 94.75 O \\\\nATOM 3329 N ALA A 424 13.032 12.634 -10.641 1.00 90.85 N \\\\nATOM 3330 CA ALA A 424 14.086 13.644 -10.487 1.00 90.85 C \\\\nATOM 3331 C ALA A 424 15.119 13.325 -9.386 1.00 90.85 C \\\\nATOM 3332 CB ALA A 424 13.394 14.987 -10.215 1.00 90.85 C \\\\nATOM 3333 O ALA A 424 16.310 13.545 -9.571 1.00 90.85 O \\\\nATOM 3334 N GLU A 425 14.673 12.721 -8.282 1.00 88.72 N \\\\nATOM 3335 CA GLU A 425 15.503 12.405 -7.109 1.00 88.72 C \\\\nATOM 3336 C GLU A 425 16.249 11.058 -7.203 1.00 88.72 C \\\\nATOM 3337 CB GLU A 425 14.613 12.434 -5.855 1.00 88.72 C \\\\nATOM 3338 O GLU A 425 16.893 10.619 -6.248 1.00 88.72 O \\\\nATOM 3339 CG GLU A 425 13.885 13.769 -5.639 1.00 88.72 C \\\\nATOM 3340 CD GLU A 425 14.850 14.961 -5.596 1.00 88.72 C \\\\nATOM 3341 OE1 GLU A 425 14.500 15.996 -6.201 1.00 88.72 O \\\\nATOM 3342 OE2 GLU A 425 15.920 14.809 -4.965 1.00 88.72 O \\\\nATOM 3343 N TYR A 426 16.141 10.341 -8.325 1.00 94.62 N \\\\nATOM 3344 CA TYR A 426 16.680 8.990 -8.470 1.00 94.62 C \\\\nATOM 3345 C TYR A 426 17.466 8.829 -9.770 1.00 94.62 C \\\\nATOM 3346 CB TYR A 426 15.548 7.953 -8.380 1.00 94.62 C \\\\nATOM 3347 O TYR A 426 17.192 9.450 -10.787 1.00 94.62 O \\\\nATOM 3348 CG TYR A 426 14.758 7.996 -7.084 1.00 94.62 C \\\\nATOM 3349 CD1 TYR A 426 15.210 7.314 -5.935 1.00 94.62 C \\\\nATOM 3350 CD2 TYR A 426 13.601 8.790 -7.013 1.00 94.62 C \\\\nATOM 3351 CE1 TYR A 426 14.518 7.457 -4.715 1.00 94.62 C \\\\nATOM 3352 CE2 TYR A 426 12.900 8.928 -5.804 1.00 94.62 C \\\\nATOM 3353 OH TYR A 426 12.775 8.538 -3.454 1.00 94.62 O \\\\nATOM 3354 CZ TYR A 426 13.380 8.292 -4.645 1.00 94.62 C \\\\nATOM 3355 N ARG A 427 18.413 7.880 -9.782 1.00 94.90 N \\\\nATOM 3356 CA ARG A 427 19.152 7.509 -11.005 1.00 94.90 C \\\\nATOM 3357 C ARG A 427 18.225 7.072 -12.151 1.00 94.90 C \\\\nATOM 3358 CB ARG A 427 20.176 6.414 -10.660 1.00 94.90 C \\\\nATOM 3359 O ARG A 427 18.559 7.251 -13.317 1.00 94.90 O \\\\nATOM 3360 CG ARG A 427 21.004 5.978 -11.879 1.00 94.90 C \\\\nATOM 3361 CD ARG A 427 22.040 4.915 -11.509 1.00 94.90 C \\\\nATOM 3362 NE ARG A 427 22.699 4.393 -12.720 1.00 94.90 N \\\\nATOM 3363 NH1 ARG A 427 23.904 2.705 -11.734 1.00 94.90 N \\\\nATOM 3364 NH2 ARG A 427 24.039 3.017 -13.941 1.00 94.90 N \\\\nATOM 3365 CZ ARG A 427 23.540 3.376 -12.793 1.00 94.90 C \\\\nATOM 3366 N ARG A 428 17.099 6.434 -11.823 1.00 96.14 N \\\\nATOM 3367 CA ARG A 428 16.100 5.985 -12.799 1.00 96.14 C \\\\nATOM 3368 C ARG A 428 15.198 7.158 -13.132 1.00 96.14 C \\\\nATOM 3369 CB ARG A 428 15.268 4.838 -12.216 1.00 96.14 C \\\\nATOM 3370 O ARG A 428 14.451 7.585 -12.263 1.00 96.14 O \\\\nATOM 3371 CG ARG A 428 16.093 3.561 -12.091 1.00 96.14 C \\\\nATOM 3372 CD ARG A 428 15.265 2.482 -11.392 1.00 96.14 C \\\\nATOM 3373 NE ARG A 428 16.005 1.210 -11.355 1.00 96.14 N \\\\nATOM 3374 NH1 ARG A 428 17.371 1.723 -9.587 1.00 96.14 N \\\\nATOM 3375 NH2 ARG A 428 17.678 -0.190 -10.713 1.00 96.14 N \\\\nATOM 3376 CZ ARG A 428 17.010 0.917 -10.552 1.00 96.14 C \\\\nATOM 3377 N GLN A 429 15.240 7.633 -14.370 1.00 95.89 N \\\\nATOM 3378 CA GLN A 429 14.371 8.733 -14.772 1.00 95.89 C \\\\nATOM 3379 C GLN A 429 12.954 8.245 -15.040 1.00 95.89 C \\\\nATOM 3380 CB GLN A 429 14.980 9.512 -15.947 1.00 95.89 C \\\\nATOM 3381 O GLN A 429 12.033 8.853 -14.522 1.00 95.89 O \\\\nATOM 3382 CG GLN A 429 16.301 10.202 -15.553 1.00 95.89 C \\\\nATOM 3383 CD GLN A 429 16.155 11.065 -14.298 1.00 95.89 C \\\\nATOM 3384 NE2 GLN A 429 17.031 10.926 -13.331 1.00 95.89 N \\\\nATOM 3385 OE1 GLN A 429 15.202 11.803 -14.129 1.00 95.89 O \\\\nATOM 3386 N THR A 430 12.769 7.111 -15.726 1.00 96.48 N \\\\nATOM 3387 CA THR A 430 11.447 6.572 -16.089 1.00 96.48 C \\\\nATOM 3388 C THR A 430 10.968 5.455 -15.162 1.00 96.48 C \\\\nATOM 3389 CB THR A 430 11.421 6.056 -17.537 1.00 96.48 C \\\\nATOM 3390 O THR A 430 11.773 4.695 -14.610 1.00 96.48 O \\\\nATOM 3391 CG2 THR A 430 11.843 7.080 -18.590 1.00 96.48 C \\\\nATOM 3392 OG1 THR A 430 12.267 4.932 -17.662 1.00 96.48 O \\\\nATOM 3393 N VAL A 431 9.646 5.283 -15.053 1.00 97.27 N \\\\nATOM 3394 CA VAL A 431 9.054 4.138 -14.332 1.00 97.27 C \\\\nATOM 3395 C VAL A 431 9.428 2.805 -14.989 1.00 97.27 C \\\\nATOM 3396 CB VAL A 431 7.529 4.293 -14.205 1.00 97.27 C \\\\nATOM 3397 O VAL A 431 9.712 1.830 -14.299 1.00 97.27 O \\\\nATOM 3398 CG1 VAL A 431 6.798 4.130 -15.543 1.00 97.27 C \\\\nATOM 3399 CG2 VAL A 431 6.972 3.310 -13.171 1.00 97.27 C \\\\nATOM 3400 N THR A 432 9.565 2.786 -16.317 1.00 97.83 N \\\\nATOM 3401 CA THR A 432 9.991 1.622 -17.112 1.00 97.83 C \\\\nATOM 3402 C THR A 432 11.432 1.181 -16.834 1.00 97.83 C \\\\nATOM 3403 CB THR A 432 9.828 1.917 -18.611 1.00 97.83 C \\\\nATOM 3404 O THR A 432 11.830 0.084 -17.210 1.00 97.83 O \\\\nATOM 3405 CG2 THR A 432 8.359 2.070 -19.004 1.00 97.83 C \\\\nATOM 3406 OG1 THR A 432 10.470 3.129 -18.958 1.00 97.83 O \\\\nATOM 3407 N SER A 433 12.220 1.998 -16.126 1.00 97.46 N \\\\nATOM 3408 CA SER A 433 13.549 1.621 -15.624 1.00 97.46 C \\\\nATOM 3409 C SER A 433 13.496 0.910 -14.263 1.00 97.46 C \\\\nATOM 3410 CB SER A 433 14.424 2.869 -15.505 1.00 97.46 C \\\\nATOM 3411 O SER A 433 14.527 0.454 -13.744 1.00 97.46 O \\\\nATOM 3412 OG SER A 433 14.595 3.524 -16.742 1.00 97.46 O \\\\nATOM 3413 N THR A 434 12.325 0.861 -13.621 1.00 98.11 N \\\\nATOM 3414 CA THR A 434 12.142 0.204 -12.325 1.00 98.11 C \\\\nATOM 3415 C THR A 434 11.928 -1.301 -12.509 1.00 98.11 C \\\\nATOM 3416 CB THR A 434 11.031 0.812 -11.463 1.00 98.11 C \\\\nATOM 3417 O THR A 434 11.259 -1.723 -13.452 1.00 98.11 O \\\\nATOM 3418 CG2 THR A 434 11.186 2.317 -11.262 1.00 98.11 C \\\\nATOM 3419 OG1 THR A 434 9.764 0.546 -11.980 1.00 98.11 O \\\\nATOM 3420 N PRO A 435 12.504 -2.154 -11.642 1.00 98.30 N \\\\nATOM 3421 CA PRO A 435 12.450 -3.596 -11.871 1.00 98.30 C \\\\nATOM 3422 C PRO A 435 11.050 -4.194 -11.694 1.00 98.30 C \\\\nATOM 3423 CB PRO A 435 13.442 -4.209 -10.878 1.00 98.30 C \\\\nATOM 3424 O PRO A 435 10.746 -5.203 -12.319 1.00 98.30 O \\\\nATOM 3425 CG PRO A 435 14.335 -3.047 -10.462 1.00 98.30 C \\\\nATOM 3426 CD PRO A 435 13.396 -1.854 -10.532 1.00 98.30 C \\\\nATOM 3427 N CYS A 436 10.221 -3.614 -10.823 1.00 98.65 N \\\\nATOM 3428 CA CYS A 436 8.884 -4.108 -10.502 1.00 98.65 C \\\\nATOM 3429 C CYS A 436 7.965 -2.926 -10.214 1.00 98.65 C \\\\nATOM 3430 CB CYS A 436 8.944 -5.000 -9.249 1.00 98.65 C \\\\nATOM 3431 O CYS A 436 8.176 -2.221 -9.224 1.00 98.65 O \\\\nATOM 3432 SG CYS A 436 10.042 -6.419 -9.493 1.00 98.65 S \\\\nATOM 3433 N TRP A 437 6.930 -2.745 -11.023 1.00 98.76 N \\\\nATOM 3434 CA TRP A 437 5.951 -1.685 -10.817 1.00 98.76 C \\\\nATOM 3435 C TRP A 437 4.570 -2.099 -11.314 1.00 98.76 C \\\\nATOM 3436 CB TRP A 437 6.443 -0.390 -11.475 1.00 98.76 C \\\\nATOM 3437 O TRP A 437 4.419 -3.065 -12.058 1.00 98.76 O \\\\nATOM 3438 CG TRP A 437 6.614 -0.447 -12.954 1.00 98.76 C \\\\nATOM 3439 CD1 TRP A 437 7.657 -1.001 -13.607 1.00 98.76 C \\\\nATOM 3440 CD2 TRP A 437 5.717 0.067 -13.983 1.00 98.76 C \\\\nATOM 3441 CE2 TRP A 437 6.302 -0.203 -15.253 1.00 98.76 C \\\\nATOM 3442 CE3 TRP A 437 4.477 0.739 -13.970 1.00 98.76 C \\\\nATOM 3443 NE1 TRP A 437 7.475 -0.852 -14.960 1.00 98.76 N \\\\nATOM 3444 CH2 TRP A 437 4.433 0.768 -16.408 1.00 98.76 C \\\\nATOM 3445 CZ2 TRP A 437 5.676 0.125 -16.457 1.00 98.76 C \\\\nATOM 3446 CZ3 TRP A 437 3.846 1.096 -15.175 1.00 98.76 C \\\\nATOM 3447 N ILE A 438 3.554 -1.388 -10.843 1.00 98.75 N \\\\nATOM 3448 CA ILE A 438 2.160 -1.576 -11.224 1.00 98.75 C \\\\nATOM 3449 C ILE A 438 1.571 -0.277 -11.759 1.00 98.75 C \\\\nATOM 3450 CB ILE A 438 1.303 -2.146 -10.072 1.00 98.75 C \\\\nATOM 3451 O ILE A 438 1.939 0.818 -11.324 1.00 98.75 O \\\\nATOM 3452 CG1 ILE A 438 1.413 -1.301 -8.783 1.00 98.75 C \\\\nATOM 3453 CG2 ILE A 438 1.664 -3.623 -9.848 1.00 98.75 C \\\\nATOM 3454 CD1 ILE A 438 0.412 -1.684 -7.687 1.00 98.75 C \\\\nATOM 3455 N GLU A 439 0.626 -0.425 -12.674 1.00 98.66 N \\\\nATOM 3456 CA GLU A 439 -0.226 0.638 -13.185 1.00 98.66 C \\\\nATOM 3457 C GLU A 439 -1.659 0.385 -12.722 1.00 98.66 C \\\\nATOM 3458 CB GLU A 439 -0.113 0.684 -14.711 1.00 98.66 C \\\\nATOM 3459 O GLU A 439 -2.210 -0.693 -12.943 1.00 98.66 O \\\\nATOM 3460 CG GLU A 439 -0.773 1.930 -15.307 1.00 98.66 C \\\\nATOM 3461 CD GLU A 439 -0.329 2.117 -16.764 1.00 98.66 C \\\\nATOM 3462 OE1 GLU A 439 -0.586 1.190 -17.567 1.00 98.66 O \\\\nATOM 3463 OE2 GLU A 439 0.372 3.136 -17.029 1.00 98.66 O \\\\nATOM 3464 N LEU A 440 -2.231 1.368 -12.034 1.00 98.22 N \\\\nATOM 3465 CA LEU A 440 -3.578 1.347 -11.491 1.00 98.22 C \\\\nATOM 3466 C LEU A 440 -4.466 2.258 -12.334 1.00 98.22 C \\\\nATOM 3467 CB LEU A 440 -3.521 1.826 -10.023 1.00 98.22 C \\\\nATOM 3468 O LEU A 440 -4.170 3.444 -12.452 1.00 98.22 O \\\\nATOM 3469 CG LEU A 440 -4.725 1.370 -9.189 1.00 98.22 C \\\\nATOM 3470 CD1 LEU A 440 -4.507 -0.084 -8.800 1.00 98.22 C \\\\nATOM 3471 CD2 LEU A 440 -4.859 2.179 -7.899 1.00 98.22 C \\\\nATOM 3472 N HIS A 441 -5.560 1.729 -12.870 1.00 98.13 N \\\\nATOM 3473 CA HIS A 441 -6.609 2.516 -13.522 1.00 98.13 C \\\\nATOM 3474 C HIS A 441 -7.832 2.593 -12.619 1.00 98.13 C \\\\nATOM 3475 CB HIS A 441 -6.971 1.905 -14.878 1.00 98.13 C \\\\nATOM 3476 O HIS A 441 -8.337 1.558 -12.183 1.00 98.13 O \\\\nATOM 3477 CG HIS A 441 -5.885 1.987 -15.917 1.00 98.13 C \\\\nATOM 3478 CD2 HIS A 441 -4.763 2.768 -15.870 1.00 98.13 C \\\\nATOM 3479 ND1 HIS A 441 -5.880 1.348 -17.135 1.00 98.13 N \\\\nATOM 3480 CE1 HIS A 441 -4.779 1.739 -17.802 1.00 98.13 C \\\\nATOM 3481 NE2 HIS A 441 -4.070 2.613 -17.069 1.00 98.13 N \\\\nATOM 3482 N LEU A 442 -8.298 3.808 -12.333 1.00 97.65 N \\\\nATOM 3483 CA LEU A 442 -9.493 4.052 -11.528 1.00 97.65 C \\\\nATOM 3484 C LEU A 442 -10.723 4.098 -12.435 1.00 97.65 C \\\\nATOM 3485 CB LEU A 442 -9.317 5.340 -10.712 1.00 97.65 C \\\\nATOM 3486 O LEU A 442 -10.966 5.081 -13.135 1.00 97.65 O \\\\nATOM 3487 CG LEU A 442 -8.113 5.327 -9.756 1.00 97.65 C \\\\nATOM 3488 CD1 LEU A 442 -8.076 6.651 -9.009 1.00 97.65 C \\\\nATOM 3489 CD2 LEU A 442 -8.185 4.200 -8.722 1.00 97.65 C \\\\nATOM 3490 N ASN A 443 -11.505 3.022 -12.414 1.00 96.77 N \\\\nATOM 3491 CA ASN A 443 -12.575 2.797 -13.384 1.00 96.77 C \\\\nATOM 3492 C ASN A 443 -13.730 3.790 -13.230 1.00 96.77 C \\\\nATOM 3493 CB ASN A 443 -13.079 1.359 -13.224 1.00 96.77 C \\\\nATOM 3494 O ASN A 443 -14.340 4.164 -14.223 1.00 96.77 O \\\\nATOM 3495 CG ASN A 443 -12.053 0.308 -13.601 1.00 96.77 C \\\\nATOM 3496 ND2 ASN A 443 -12.176 -0.876 -13.059 1.00 96.77 N \\\\nATOM 3497 OD1 ASN A 443 -11.132 0.524 -14.365 1.00 96.77 O \\\\nATOM 3498 N GLY A 444 -14.029 4.226 -12.003 1.00 94.54 N \\\\nATOM 3499 CA GLY A 444 -15.098 5.191 -11.745 1.00 94.54 C \\\\nATOM 3500 C GLY A 444 -14.801 6.553 -12.378 1.00 94.54 C \\\\nATOM 3501 O GLY A 444 -15.563 7.000 -13.235 1.00 94.54 O \\\\nATOM 3502 N PRO A 445 -13.667 7.192 -12.030 1.00 95.57 N \\\\nATOM 3503 CA PRO A 445 -13.183 8.395 -12.703 1.00 95.57 C \\\\nATOM 3504 C PRO A 445 -13.102 8.266 -14.232 1.00 95.57 C \\\\nATOM 3505 CB PRO A 445 -11.812 8.667 -12.076 1.00 95.57 C \\\\nATOM 3506 O PRO A 445 -13.582 9.157 -14.930 1.00 95.57 O \\\\nATOM 3507 CG PRO A 445 -11.990 8.153 -10.650 1.00 95.57 C \\\\nATOM 3508 CD PRO A 445 -12.852 6.911 -10.854 1.00 95.57 C \\\\nATOM 3509 N LEU A 446 -12.584 7.146 -14.758 1.00 96.12 N \\\\nATOM 3510 CA LEU A 446 -12.530 6.893 -16.207 1.00 96.12 C \\\\nATOM 3511 C LEU A 446 -13.920 6.832 -16.847 1.00 96.12 C \\\\nATOM 3512 CB LEU A 446 -11.786 5.576 -16.497 1.00 96.12 C \\\\nATOM 3513 O LEU A 446 -14.143 7.458 -17.876 1.00 96.12 O \\\\nATOM 3514 CG LEU A 446 -10.261 5.663 -16.366 1.00 96.12 C \\\\nATOM 3515 CD1 LEU A 446 -9.644 4.269 -16.456 1.00 96.12 C \\\\nATOM 3516 CD2 LEU A 446 -9.629 6.538 -17.453 1.00 96.12 C \\\\nATOM 3517 N GLN A 447 -14.867 6.114 -16.239 1.00 93.99 N \\\\nATOM 3518 CA GLN A 447 -16.236 6.022 -16.746 1.00 93.99 C \\\\nATOM 3519 C GLN A 447 -16.928 7.388 -16.734 1.00 93.99 C \\\\nATOM 3520 CB GLN A 447 -17.025 5.007 -15.900 1.00 93.99 C \\\\nATOM 3521 O GLN A 447 -17.694 7.710 -17.641 1.00 93.99 O \\\\nATOM 3522 CG GLN A 447 -18.453 4.827 -16.434 1.00 93.99 C \\\\nATOM 3523 CD GLN A 447 -19.274 3.840 -15.619 1.00 93.99 C \\\\nATOM 3524 NE2 GLN A 447 -19.847 2.835 -16.240 1.00 93.99 N \\\\nATOM 3525 OE1 GLN A 447 -19.488 3.984 -14.428 1.00 93.99 O \\\\nATOM 3526 N TRP A 448 -16.685 8.201 -15.705 1.00 93.61 N \\\\nATOM 3527 CA TRP A 448 -17.250 9.544 -15.649 1.00 93.61 C \\\\nATOM 3528 C TRP A 448 -16.668 10.445 -16.736 1.00 93.61 C \\\\nATOM 3529 CB TRP A 448 -17.020 10.139 -14.266 1.00 93.61 C \\\\nATOM 3530 O TRP A 448 -17.416 11.158 -17.403 1.00 93.61 O \\\\nATOM 3531 CG TRP A 448 -17.873 11.319 -13.917 1.00 93.61 C \\\\nATOM 3532 CD1 TRP A 448 -18.899 11.839 -14.637 1.00 93.61 C \\\\nATOM 3533 CD2 TRP A 448 -17.793 12.127 -12.714 1.00 93.61 C \\\\nATOM 3534 CE2 TRP A 448 -18.872 13.057 -12.721 1.00 93.61 C \\\\nATOM 3535 CE3 TRP A 448 -16.926 12.138 -11.604 1.00 93.61 C \\\\nATOM 3536 NE1 TRP A 448 -19.496 12.864 -13.931 1.00 93.61 N \\\\nATOM 3537 CH2 TRP A 448 -18.250 13.892 -10.548 1.00 93.61 C \\\\nATOM 3538 CZ2 TRP A 448 -19.116 13.916 -11.649 1.00 93.61 C \\\\nATOM 3539 CZ3 TRP A 448 -17.154 13.009 -10.530 1.00 93.61 C \\\\nATOM 3540 N LEU A 449 -15.354 10.358 -16.948 1.00 94.28 N \\\\nATOM 3541 CA LEU A 449 -14.655 11.076 -18.003 1.00 94.28 C \\\\nATOM 3542 C LEU A 449 -15.173 10.695 -19.397 1.00 94.28 C \\\\nATOM 3543 CB LEU A 449 -13.153 10.779 -17.862 1.00 94.28 C \\\\nATOM 3544 O LEU A 449 -15.466 11.579 -20.195 1.00 94.28 O \\\\nATOM 3545 CG LEU A 449 -12.289 11.610 -18.815 1.00 94.28 C \\\\nATOM 3546 CD1 LEU A 449 -12.347 13.079 -18.418 1.00 94.28 C \\\\nATOM 3547 CD2 LEU A 449 -10.841 11.143 -18.742 1.00 94.28 C \\\\nATOM 3548 N ASP A 450 -15.347 9.401 -19.664 1.00 92.60 N \\\\nATOM 3549 CA ASP A 450 -15.885 8.874 -20.924 1.00 92.60 C \\\\nATOM 3550 C ASP A 450 -17.291 9.424 -21.227 1.00 92.60 C \\\\nATOM 3551 CB ASP A 450 -15.886 7.343 -20.822 1.00 92.60 C \\\\nATOM 3552 O ASP A 450 -17.558 9.945 -22.313 1.00 92.60 O \\\\nATOM 3553 CG ASP A 450 -16.420 6.688 -22.093 1.00 92.60 C \\\\nATOM 3554 OD1 ASP A 450 -15.698 6.749 -23.110 1.00 92.60 O \\\\nATOM 3555 OD2 ASP A 450 -17.537 6.128 -22.015 1.00 92.60 O \\\\nATOM 3556 N LYS A 451 -18.181 9.440 -20.225 1.00 91.83 N \\\\nATOM 3557 CA LYS A 451 -19.519 10.041 -20.363 1.00 91.83 C \\\\nATOM 3558 C LYS A 451 -19.490 11.549 -20.640 1.00 91.83 C \\\\nATOM 3559 CB LYS A 451 -20.346 9.800 -19.104 1.00 91.83 C \\\\nATOM 3560 O LYS A 451 -20.411 12.062 -21.264 1.00 91.83 O \\\\nATOM 3561 CG LYS A 451 -20.774 8.346 -18.886 1.00 91.83 C \\\\nATOM 3562 CD LYS A 451 -21.546 8.299 -17.564 1.00 91.83 C \\\\nATOM 3563 CE LYS A 451 -21.927 6.876 -17.167 1.00 91.83 C \\\\nATOM 3564 NZ LYS A 451 -22.588 6.894 -15.839 1.00 91.83 N \\\\nATOM 3565 N VAL A 452 -18.482 12.272 -20.151 1.00 91.75 N \\\\nATOM 3566 CA VAL A 452 -18.313 13.704 -20.452 1.00 91.75 C \\\\nATOM 3567 C VAL A 452 -17.764 13.886 -21.868 1.00 91.75 C \\\\nATOM 3568 CB VAL A 452 -17.432 14.393 -19.392 1.00 91.75 C \\\\nATOM 3569 O VAL A 452 -18.312 14.673 -22.635 1.00 91.75 O \\\\nATOM 3570 CG1 VAL A 452 -17.045 15.822 -19.781 1.00 91.75 C \\\\nATOM 3571 CG2 VAL A 452 -18.180 14.477 -18.054 1.00 91.75 C \\\\nATOM 3572 N LEU A 453 -16.729 13.131 -22.246 1.00 91.05 N \\\\nATOM 3573 CA LEU A 453 -16.115 13.199 -23.577 1.00 91.05 C \\\\nATOM 3574 C LEU A 453 -17.106 12.863 -24.695 1.00 91.05 C \\\\nATOM 3575 CB LEU A 453 -14.907 12.248 -23.633 1.00 91.05 C \\\\nATOM 3576 O LEU A 453 -17.135 13.558 -25.707 1.00 91.05 O \\\\nATOM 3577 CG LEU A 453 -13.657 12.782 -22.915 1.00 91.05 C \\\\nATOM 3578 CD1 LEU A 453 -12.607 11.677 -22.819 1.00 91.05 C \\\\nATOM 3579 CD2 LEU A 453 -13.034 13.964 -23.666 1.00 91.05 C \\\\nATOM 3580 N THR A 454 -17.974 11.870 -24.489 1.00 88.74 N \\\\nATOM 3581 CA THR A 454 -19.038 11.510 -25.446 1.00 88.74 C \\\\nATOM 3582 C THR A 454 -20.045 12.639 -25.704 1.00 88.74 C \\\\nATOM 3583 CB THR A 454 -19.797 10.249 -25.000 1.00 88.74 C \\\\nATOM 3584 O THR A 454 -20.705 12.629 -26.739 1.00 88.74 O \\\\nATOM 3585 CG2 THR A 454 -18.964 8.980 -25.160 1.00 88.74 C \\\\nATOM 3586 OG1 THR A 454 -20.152 10.317 -23.644 1.00 88.74 O \\\\nATOM 3587 N GLN A 455 -20.145 13.631 -24.811 1.00 86.80 N \\\\nATOM 3588 CA GLN A 455 -21.014 14.806 -24.960 1.00 86.80 C \\\\nATOM 3589 C GLN A 455 -20.277 16.044 -25.514 1.00 86.80 C \\\\nATOM 3590 CB GLN A 455 -21.657 15.128 -23.598 1.00 86.80 C \\\\nATOM 3591 O GLN A 455 -20.926 16.977 -25.978 1.00 86.80 O \\\\nATOM 3592 CG GLN A 455 -22.542 14.008 -23.028 1.00 86.80 C \\\\nATOM 3593 CD GLN A 455 -23.867 13.803 -23.755 1.00 86.80 C \\\\nATOM 3594 NE2 GLN A 455 -24.498 12.666 -23.561 1.00 86.80 N \\\\nATOM 3595 OE1 GLN A 455 -24.396 14.643 -24.464 1.00 86.80 O \\\\nATOM 3596 N MET A 456 -18.937 16.067 -25.489 1.00 83.78 N \\\\nATOM 3597 CA MET A 456 -18.105 17.230 -25.855 1.00 83.78 C \\\\nATOM 3598 C MET A 456 -17.816 17.361 -27.364 1.00 83.78 C \\\\nATOM 3599 CB MET A 456 -16.786 17.177 -25.059 1.00 83.78 C \\\\nATOM 3600 O MET A 456 -17.165 18.316 -27.781 1.00 83.78 O \\\\nATOM 3601 CG MET A 456 -16.946 17.591 -23.591 1.00 83.78 C \\\\nATOM 3602 SD MET A 456 -17.155 19.371 -23.298 1.00 83.78 S \\\\nATOM 3603 CE MET A 456 -15.520 20.010 -23.739 1.00 83.78 C \\\\nATOM 3604 N GLY A 457 -18.270 16.423 -28.200 1.00 82.72 N \\\\nATOM 3605 CA GLY A 457 -17.965 16.416 -29.636 1.00 82.72 C \\\\nATOM 3606 C GLY A 457 -16.554 15.898 -29.944 1.00 82.72 C \\\\nATOM 3607 O GLY A 457 -16.102 14.932 -29.336 1.00 82.72 O \\\\nATOM 3608 N SER A 458 -15.869 16.502 -30.919 1.00 82.57 N \\\\nATOM 3609 CA SER A 458 -14.536 16.088 -31.390 1.00 82.57 C \\\\nATOM 3610 C SER A 458 -13.502 17.216 -31.256 1.00 82.57 C \\\\nATOM 3611 CB SER A 458 -14.626 15.612 -32.849 1.00 82.57 C \\\\nATOM 3612 O SER A 458 -13.892 18.384 -31.189 1.00 82.57 O \\\\nATOM 3613 OG SER A 458 -14.997 16.664 -33.725 1.00 82.57 O \\\\nATOM 3614 N PRO A 459 -12.187 16.917 -31.300 1.00 83.95 N \\\\nATOM 3615 CA PRO A 459 -11.150 17.944 -31.404 1.00 83.95 C \\\\nATOM 3616 C PRO A 459 -11.398 18.912 -32.571 1.00 83.95 C \\\\nATOM 3617 CB PRO A 459 -9.830 17.189 -31.592 1.00 83.95 C \\\\nATOM 3618 O PRO A 459 -11.916 18.519 -33.619 1.00 83.95 O \\\\nATOM 3619 CG PRO A 459 -10.104 15.818 -30.980 1.00 83.95 C \\\\nATOM 3620 CD PRO A 459 -11.586 15.591 -31.267 1.00 83.95 C \\\\nATOM 3621 N SER A 460 -10.991 20.174 -32.407 1.00 82.81 N \\\\nATOM 3622 CA SER A 460 -11.108 21.203 -33.452 1.00 82.81 C \\\\nATOM 3623 C SER A 460 -10.191 20.929 -34.648 1.00 82.81 C \\\\nATOM 3624 CB SER A 460 -10.787 22.579 -32.856 1.00 82.81 C \\\\nATOM 3625 O SER A 460 -10.555 21.194 -35.795 1.00 82.81 O \\\\nATOM 3626 OG SER A 460 -9.520 22.558 -32.219 1.00 82.81 O \\\\nATOM 3627 N VAL A 461 -9.008 20.365 -34.391 1.00 84.86 N \\\\nATOM 3628 CA VAL A 461 -8.042 19.977 -35.421 1.00 84.86 C \\\\nATOM 3629 C VAL A 461 -8.386 18.581 -35.931 1.00 84.86 C \\\\nATOM 3630 CB VAL A 461 -6.596 20.052 -34.897 1.00 84.86 C \\\\nATOM 3631 O VAL A 461 -8.351 17.603 -35.184 1.00 84.86 O \\\\nATOM 3632 CG1 VAL A 461 -5.591 19.735 -36.012 1.00 84.86 C \\\\nATOM 3633 CG2 VAL A 461 -6.274 21.456 -34.364 1.00 84.86 C \\\\nATOM 3634 N ARG A 462 -8.705 18.476 -37.224 1.00 86.91 N \\\\nATOM 3635 CA ARG A 462 -8.912 17.178 -37.878 1.00 86.91 C \\\\nATOM 3636 C ARG A 462 -7.580 16.446 -38.015 1.00 86.91 C \\\\nATOM 3637 CB ARG A 462 -9.587 17.337 -39.247 1.00 86.91 C \\\\nATOM 3638 O ARG A 462 -6.581 17.039 -38.412 1.00 86.91 O \\\\nATOM 3639 CG ARG A 462 -11.013 17.890 -39.126 1.00 86.91 C \\\\nATOM 3640 CD ARG A 462 -11.684 17.905 -40.502 1.00 86.91 C \\\\nATOM 3641 NE ARG A 462 -13.033 18.495 -40.434 1.00 86.91 N \\\\nATOM 3642 NH1 ARG A 462 -13.544 18.318 -42.665 1.00 86.91 N \\\\nATOM 3643 NH2 ARG A 462 -15.020 19.234 -41.262 1.00 86.91 N \\\\nATOM 3644 CZ ARG A 462 -13.857 18.679 -41.451 1.00 86.91 C \\\\nATOM 3645 N CYS A 463 -7.589 15.148 -37.736 1.00 86.96 N \\\\nATOM 3646 CA CYS A 463 -6.437 14.287 -37.969 1.00 86.96 C \\\\nATOM 3647 C CYS A 463 -6.320 13.944 -39.464 1.00 86.96 C \\\\nATOM 3648 CB CYS A 463 -6.570 13.047 -37.079 1.00 86.96 C \\\\nATOM 3649 O CYS A 463 -7.328 13.671 -40.121 1.00 86.96 O \\\\nATOM 3650 SG CYS A 463 -4.996 12.153 -37.080 1.00 86.96 S \\\\nATOM 3651 N SER A 464 -5.099 13.967 -40.000 1.00 88.07 N \\\\nATOM 3652 CA SER A 464 -4.820 13.510 -41.363 1.00 88.07 C \\\\nATOM 3653 C SER A 464 -4.835 11.983 -41.414 1.00 88.07 C \\\\nATOM 3654 CB SER A 464 -3.461 14.040 -41.824 1.00 88.07 C \\\\nATOM 3655 O SER A 464 -4.310 11.321 -40.526 1.00 88.07 O \\\\nATOM 3656 OG SER A 464 -3.099 13.502 -43.084 1.00 88.07 O \\\\nATOM 3657 N SER A 465 -5.379 11.407 -42.485 1.00 91.00 N \\\\nATOM 3658 CA SER A 465 -5.290 9.965 -42.748 1.00 91.00 C \\\\nATOM 3659 C SER A 465 -3.976 9.551 -43.433 1.00 91.00 C \\\\nATOM 3660 CB SER A 465 -6.508 9.521 -43.561 1.00 91.00 C \\\\nATOM 3661 O SER A 465 -3.864 8.409 -43.870 1.00 91.00 O \\\\nATOM 3662 OG SER A 465 -6.528 10.173 -44.818 1.00 91.00 O \\\\nATOM 3663 N MET A 466 -3.021 10.477 -43.604 1.00 85.74 N \\\\nATOM 3664 CA MET A 466 -1.770 10.264 -44.353 1.00 85.74 C \\\\nATOM 3665 C MET A 466 -0.494 10.702 -43.614 1.00 85.74 C \\\\nATOM 3666 CB MET A 466 -1.822 11.027 -45.692 1.00 85.74 C \\\\nATOM 3667 O MET A 466 0.590 10.472 -44.144 1.00 85.74 O \\\\nATOM 3668 CG MET A 466 -2.996 10.644 -46.597 1.00 85.74 C \\\\nATOM 3669 SD MET A 466 -2.952 11.423 -48.240 1.00 85.74 S \\\\nATOM 3670 CE MET A 466 -1.732 10.371 -49.073 1.00 85.74 C \\\\nATOM 3671 N SER A 467 -0.609 11.397 -42.475 1.00 72.38 N \\\\nATOM 3672 CA SER A 467 0.539 11.969 -41.746 1.00 72.38 C \\\\nATOM 3673 C SER A 467 1.298 10.949 -40.918 1.00 72.38 C \\\\nATOM 3674 CB SER A 467 0.108 13.100 -40.821 1.00 72.38 C \\\\nATOM 3675 O SER A 467 0.599 10.142 -40.264 1.00 72.38 O \\\\nATOM 3676 OG SER A 467 -0.858 12.568 -39.944 1.00 72.38 O \\\\nATOM 3677 OXT SER A 467 2.532 11.126 -40.865 1.00 72.38 O \\\\nTER 3678 SER A 467 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 9, 'score': 0}, {'residue_no': 10, 'score': 0}, {'residue_no': 11, 'score': 0}, {'residue_no': 12, 'score': 0}, {'residue_no': 13, 'score': 0}, {'residue_no': 14, 'score': 0}, {'residue_no': 15, 'score': 0}, {'residue_no': 16, 'score': 0}, {'residue_no': 17, 'score': 0}, {'residue_no': 18, 'score': 0}, {'residue_no': 19, 'score': 0}, {'residue_no': 20, 'score': 0}, {'residue_no': 21, 'score': 0}, {'residue_no': 22, 'score': 0}, {'residue_no': 23, 'score': 0}, {'residue_no': 24, 'score': 0}, {'residue_no': 25, 'score': 0}, {'residue_no': 26, 'score': 0}, {'residue_no': 27, 'score': 0}, {'residue_no': 28, 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{'residue_no': 419, 'score': 0.2302}, {'residue_no': 420, 'score': 0.2175}, {'residue_no': 421, 'score': 0.2119}, {'residue_no': 422, 'score': 0.2108}, {'residue_no': 423, 'score': 0.2133}, {'residue_no': 424, 'score': 0.2155}, {'residue_no': 425, 'score': 0.2078}], 'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 3 (P84022) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 425 UNP P84022 SMAD3_HUMAN 1 425 \\\\nSEQRES 1 A 425 MET SER SER ILE LEU PRO PHE THR PRO PRO ILE VAL LYS \\\\nSEQRES 2 A 425 ARG LEU LEU GLY TRP LYS LYS GLY GLU GLN ASN GLY GLN \\\\nSEQRES 3 A 425 GLU GLU LYS TRP CYS GLU LYS ALA VAL LYS SER LEU VAL \\\\nSEQRES 4 A 425 LYS LYS LEU LYS LYS THR GLY GLN LEU ASP GLU LEU GLU \\\\nSEQRES 5 A 425 LYS ALA ILE THR THR GLN ASN VAL ASN THR LYS CYS ILE \\\\nSEQRES 6 A 425 THR ILE PRO ARG SER LEU ASP GLY ARG LEU GLN VAL SER \\\\nSEQRES 7 A 425 HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG LEU \\\\nSEQRES 8 A 425 TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU ARG \\\\nSEQRES 9 A 425 ALA MET GLU LEU CYS GLU PHE ALA PHE ASN MET LYS LYS \\\\nSEQRES 10 A 425 ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG VAL \\\\nSEQRES 11 A 425 GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG HIS \\\\nSEQRES 12 A 425 THR GLU ILE PRO ALA GLU PHE PRO PRO LEU ASP ASP TYR \\\\nSEQRES 13 A 425 SER HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA GLY \\\\nSEQRES 14 A 425 ILE GLU PRO GLN SER ASN ILE PRO GLU THR PRO PRO PRO \\\\nSEQRES 15 A 425 GLY TYR LEU SER GLU ASP GLY GLU THR SER ASP HIS GLN \\\\nSEQRES 16 A 425 MET ASN HIS SER MET ASP ALA GLY SER PRO ASN LEU SER \\\\nSEQRES 17 A 425 PRO ASN PRO MET SER PRO ALA HIS ASN ASN LEU ASP LEU \\\\nSEQRES 18 A 425 GLN PRO VAL THR TYR CYS GLU PRO ALA PHE TRP CYS SER \\\\nSEQRES 19 A 425 ILE SER TYR TYR GLU LEU ASN GLN ARG VAL GLY GLU THR \\\\nSEQRES 20 A 425 PHE HIS ALA SER GLN PRO SER MET THR VAL ASP GLY PHE \\\\nSEQRES 21 A 425 THR ASP PRO SER ASN SER GLU ARG PHE CYS LEU GLY LEU \\\\nSEQRES 22 A 425 LEU SER ASN VAL ASN ARG ASN ALA ALA VAL GLU LEU THR \\\\nSEQRES 23 A 425 ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU TYR TYR ILE \\\\nSEQRES 24 A 425 GLY GLY GLU VAL PHE ALA GLU CYS LEU SER ASP SER ALA \\\\nSEQRES 25 A 425 ILE PHE VAL GLN SER PRO ASN CYS ASN GLN ARG TYR GLY \\\\nSEQRES 26 A 425 TRP HIS PRO ALA THR VAL CYS LYS ILE PRO PRO GLY CYS \\\\nSEQRES 27 A 425 ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE ALA ALA LEU \\\\nSEQRES 28 A 425 LEU ALA GLN SER VAL ASN GLN GLY PHE GLU ALA VAL TYR \\\\nSEQRES 29 A 425 GLN LEU THR ARG MET CYS THR ILE ARG MET SER PHE VAL \\\\nSEQRES 30 A 425 LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN THR VAL THR \\\\nSEQRES 31 A 425 SER THR PRO CYS TRP ILE GLU LEU HIS LEU ASN GLY PRO \\\\nSEQRES 32 A 425 LEU GLN TRP LEU ASP LYS VAL LEU THR GLN MET GLY SER \\\\nSEQRES 33 A 425 PRO SER ILE ARG CYS SER SER VAL SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 4.273 0.848 52.113 1.00 39.24 N \\\\nATOM 2 CA MET A 1 3.232 1.902 52.065 1.00 39.24 C \\\\nATOM 3 C MET A 1 2.383 1.673 50.826 1.00 39.24 C \\\\nATOM 4 CB MET A 1 3.847 3.308 52.057 1.00 39.24 C \\\\nATOM 5 O MET A 1 2.942 1.318 49.796 1.00 39.24 O \\\\nATOM 6 CG MET A 1 4.474 3.642 53.416 1.00 39.24 C \\\\nATOM 7 SD MET A 1 5.360 5.216 53.426 1.00 39.24 S \\\\nATOM 8 CE MET A 1 5.935 5.252 55.146 1.00 39.24 C \\\\nATOM 9 N SER A 2 1.062 1.771 50.948 1.00 36.12 N \\\\nATOM 10 CA SER A 2 0.109 1.246 49.960 1.00 36.12 C \\\\nATOM 11 C SER A 2 0.079 2.048 48.655 1.00 36.12 C \\\\nATOM 12 CB SER A 2 -1.295 1.213 50.580 1.00 36.12 C \\\\nATOM 13 O SER A 2 -0.137 3.258 48.672 1.00 36.12 O \\\\nATOM 14 OG SER A 2 -1.227 0.650 51.880 1.00 36.12 O \\\\nATOM 15 N SER A 3 0.231 1.370 47.514 1.00 38.89 N \\\\nATOM 16 CA SER A 3 0.023 1.960 46.189 1.00 38.89 C \\\\nATOM 17 C SER A 3 -1.462 2.235 45.957 1.00 38.89 C \\\\nATOM 18 CB SER A 3 0.557 1.029 45.093 1.00 38.89 C \\\\nATOM 19 O SER A 3 -2.252 1.303 45.792 1.00 38.89 O \\\\nATOM 20 OG SER A 3 -0.053 -0.245 45.163 1.00 38.89 O \\\\nATOM 21 N ILE A 4 -1.855 3.506 45.916 1.00 47.07 N \\\\nATOM 22 CA ILE A 4 -3.232 3.888 45.596 1.00 47.07 C \\\\nATOM 23 C ILE A 4 -3.496 3.548 44.123 1.00 47.07 C \\\\nATOM 24 CB ILE A 4 -3.468 5.379 45.927 1.00 47.07 C \\\\nATOM 25 O ILE A 4 -2.938 4.179 43.224 1.00 47.07 O \\\\nATOM 26 CG1 ILE A 4 -3.261 5.625 47.443 1.00 47.07 C \\\\nATOM 27 CG2 ILE A 4 -4.879 5.821 45.493 1.00 47.07 C \\\\nATOM 28 CD1 ILE A 4 -3.274 7.105 47.845 1.00 47.07 C \\\\nATOM 29 N LEU A 5 -4.344 2.546 43.868 1.00 53.20 N \\\\nATOM 30 CA LEU A 5 -4.810 2.232 42.516 1.00 53.20 C \\\\nATOM 31 C LEU A 5 -5.549 3.457 41.941 1.00 53.20 C \\\\nATOM 32 CB LEU A 5 -5.721 0.989 42.534 1.00 53.20 C \\\\nATOM 33 O LEU A 5 -6.408 4.021 42.625 1.00 53.20 O \\\\nATOM 34 CG LEU A 5 -4.992 -0.340 42.812 1.00 53.20 C \\\\nATOM 35 CD1 LEU A 5 -6.017 -1.450 43.037 1.00 53.20 C \\\\nATOM 36 CD2 LEU A 5 -4.094 -0.756 41.643 1.00 53.20 C \\\\nATOM 37 N PRO A 6 -5.246 3.897 40.705 1.00 60.37 N \\\\nATOM 38 CA PRO A 6 -5.812 5.125 40.159 1.00 60.37 C \\\\nATOM 39 C PRO A 6 -7.330 4.999 39.986 1.00 60.37 C \\\\nATOM 40 CB PRO A 6 -5.074 5.367 38.837 1.00 60.37 C \\\\nATOM 41 O PRO A 6 -7.816 4.186 39.200 1.00 60.37 O \\\\nATOM 42 CG PRO A 6 -4.604 3.971 38.422 1.00 60.37 C \\\\nATOM 43 CD PRO A 6 -4.319 3.294 39.760 1.00 60.37 C \\\\nATOM 44 N PHE A 7 -8.088 5.832 40.702 1.00 70.62 N \\\\nATOM 45 CA PHE A 7 -9.549 5.804 40.675 1.00 70.62 C \\\\nATOM 46 C PHE A 7 -10.094 6.178 39.288 1.00 70.62 C \\\\nATOM 47 CB PHE A 7 -10.103 6.723 41.773 1.00 70.62 C \\\\nATOM 48 O PHE A 7 -10.023 7.331 38.853 1.00 70.62 O \\\\nATOM 49 CG PHE A 7 -11.618 6.706 41.884 1.00 70.62 C \\\\nATOM 50 CD1 PHE A 7 -12.391 7.683 41.227 1.00 70.62 C \\\\nATOM 51 CD2 PHE A 7 -12.256 5.721 42.662 1.00 70.62 C \\\\nATOM 52 CE1 PHE A 7 -13.792 7.682 41.356 1.00 70.62 C \\\\nATOM 53 CE2 PHE A 7 -13.657 5.718 42.788 1.00 70.62 C \\\\nATOM 54 CZ PHE A 7 -14.425 6.699 42.137 1.00 70.62 C \\\\nATOM 55 N THR A 8 -10.670 5.201 38.590 1.00 75.98 N \\\\nATOM 56 CA THR A 8 -11.340 5.419 37.302 1.00 75.98 C \\\\nATOM 57 C THR A 8 -12.798 5.827 37.530 1.00 75.98 C \\\\nATOM 58 CB THR A 8 -11.204 4.193 36.395 1.00 75.98 C \\\\nATOM 59 O THR A 8 -13.551 5.029 38.095 1.00 75.98 O \\\\nATOM 60 CG2 THR A 8 -11.939 4.349 35.065 1.00 75.98 C \\\\nATOM 61 OG1 THR A 8 -9.832 4.107 36.111 1.00 75.98 O \\\\nATOM 62 N PRO A 9 -13.225 7.032 37.086 1.00 83.88 N \\\\nATOM 63 CA PRO A 9 -14.572 7.540 37.343 1.00 83.88 C \\\\nATOM 64 C PRO A 9 -15.673 6.578 36.863 1.00 83.88 C \\\\nATOM 65 CB PRO A 9 -14.661 8.884 36.610 1.00 83.88 C \\\\nATOM 66 O PRO A 9 -15.524 6.006 35.780 1.00 83.88 O \\\\nATOM 67 CG PRO A 9 -13.212 9.362 36.576 1.00 83.88 C \\\\nATOM 68 CD PRO A 9 -12.428 8.062 36.428 1.00 83.88 C \\\\nATOM 69 N PRO A 10 -16.809 6.445 37.578 1.00 90.89 N \\\\nATOM 70 CA PRO A 10 -17.865 5.488 37.225 1.00 90.89 C \\\\nATOM 71 C PRO A 10 -18.361 5.599 35.776 1.00 90.89 C \\\\nATOM 72 CB PRO A 10 -18.993 5.742 38.231 1.00 90.89 C \\\\nATOM 73 O PRO A 10 -18.535 4.588 35.102 1.00 90.89 O \\\\nATOM 74 CG PRO A 10 -18.247 6.237 39.468 1.00 90.89 C \\\\nATOM 75 CD PRO A 10 -17.097 7.049 38.875 1.00 90.89 C \\\\nATOM 76 N ILE A 11 -18.503 6.820 35.248 1.00 92.27 N \\\\nATOM 77 CA ILE A 11 -18.903 7.038 33.849 1.00 92.27 C \\\\nATOM 78 C ILE A 11 -17.867 6.545 32.827 1.00 92.27 C \\\\nATOM 79 CB ILE A 11 -19.300 8.510 33.624 1.00 92.27 C \\\\nATOM 80 O ILE A 11 -18.248 6.053 31.772 1.00 92.27 O \\\\nATOM 81 CG1 ILE A 11 -19.974 8.665 32.243 1.00 92.27 C \\\\nATOM 82 CG2 ILE A 11 -18.109 9.479 33.789 1.00 92.27 C \\\\nATOM 83 CD1 ILE A 11 -20.932 9.855 32.186 1.00 92.27 C \\\\nATOM 84 N VAL A 12 -16.570 6.592 33.149 1.00 93.66 N \\\\nATOM 85 CA VAL A 12 -15.523 6.020 32.287 1.00 93.66 C \\\\nATOM 86 C VAL A 12 -15.661 4.498 32.246 1.00 93.66 C \\\\nATOM 87 CB VAL A 12 -14.116 6.446 32.749 1.00 93.66 C \\\\nATOM 88 O VAL A 12 -15.583 3.927 31.165 1.00 93.66 O \\\\nATOM 89 CG1 VAL A 12 -12.997 5.748 31.970 1.00 93.66 C \\\\nATOM 90 CG2 VAL A 12 -13.919 7.961 32.599 1.00 93.66 C \\\\nATOM 91 N LYS A 13 -15.937 3.848 33.388 1.00 92.88 N \\\\nATOM 92 CA LYS A 13 -16.201 2.399 33.430 1.00 92.88 C \\\\nATOM 93 C LYS A 13 -17.434 2.024 32.600 1.00 92.88 C \\\\nATOM 94 CB LYS A 13 -16.346 1.887 34.873 1.00 92.88 C \\\\nATOM 95 O LYS A 13 -17.344 1.111 31.788 1.00 92.88 O \\\\nATOM 96 CG LYS A 13 -15.076 2.061 35.721 1.00 92.88 C \\\\nATOM 97 CD LYS A 13 -15.226 1.310 37.053 1.00 92.88 C \\\\nATOM 98 CE LYS A 13 -13.955 1.424 37.902 1.00 92.88 C \\\\nATOM 99 NZ LYS A 13 -14.041 0.572 39.118 1.00 92.88 N \\\\nATOM 100 N ARG A 14 -18.548 2.762 32.738 1.00 93.78 N \\\\nATOM 101 CA ARG A 14 -19.767 2.548 31.930 1.00 93.78 C \\\\nATOM 102 C ARG A 14 -19.486 2.672 30.430 1.00 93.78 C \\\\nATOM 103 CB ARG A 14 -20.903 3.501 32.350 1.00 93.78 C \\\\nATOM 104 O ARG A 14 -19.812 1.762 29.681 1.00 93.78 O \\\\nATOM 105 CG ARG A 14 -21.494 3.160 33.730 1.00 93.78 C \\\\nATOM 106 CD ARG A 14 -22.747 3.992 34.049 1.00 93.78 C \\\\nATOM 107 NE ARG A 14 -22.461 5.438 34.153 1.00 93.78 N \\\\nATOM 108 NH1 ARG A 14 -24.649 6.160 34.141 1.00 93.78 N \\\\nATOM 109 NH2 ARG A 14 -23.035 7.644 34.071 1.00 93.78 N \\\\nATOM 110 CZ ARG A 14 -23.376 6.396 34.150 1.00 93.78 C \\\\nATOM 111 N LEU A 15 -18.822 3.747 29.998 1.00 95.91 N \\\\nATOM 112 CA LEU A 15 -18.482 3.969 28.586 1.00 95.91 C \\\\nATOM 113 C LEU A 15 -17.500 2.923 28.024 1.00 95.91 C \\\\nATOM 114 CB LEU A 15 -17.910 5.388 28.430 1.00 95.91 C \\\\nATOM 115 O LEU A 15 -17.610 2.564 26.853 1.00 95.91 O \\\\nATOM 116 CG LEU A 15 -18.943 6.527 28.539 1.00 95.91 C \\\\nATOM 117 CD1 LEU A 15 -18.201 7.866 28.557 1.00 95.91 C \\\\nATOM 118 CD2 LEU A 15 -19.925 6.546 27.366 1.00 95.91 C \\\\nATOM 119 N LEU A 16 -16.567 2.412 28.835 1.00 94.13 N \\\\nATOM 120 CA LEU A 16 -15.676 1.311 28.444 1.00 94.13 C \\\\nATOM 121 C LEU A 16 -16.401 -0.038 28.358 1.00 94.13 C \\\\nATOM 122 CB LEU A 16 -14.492 1.222 29.420 1.00 94.13 C \\\\nATOM 123 O LEU A 16 -16.011 -0.863 27.540 1.00 94.13 O \\\\nATOM 124 CG LEU A 16 -13.472 2.357 29.249 1.00 94.13 C \\\\nATOM 125 CD1 LEU A 16 -12.531 2.383 30.449 1.00 94.13 C \\\\nATOM 126 CD2 LEU A 16 -12.618 2.203 27.986 1.00 94.13 C \\\\nATOM 127 N GLY A 17 -17.481 -0.245 29.117 1.00 93.26 N \\\\nATOM 128 CA GLY A 17 -18.336 -1.435 29.003 1.00 93.26 C \\\\nATOM 129 C GLY A 17 -19.018 -1.590 27.636 1.00 93.26 C \\\\nATOM 130 O GLY A 17 -19.403 -2.694 27.270 1.00 93.26 O \\\\nATOM 131 N TRP A 18 -19.112 -0.509 26.853 1.00 94.37 N \\\\nATOM 132 CA TRP A 18 -19.606 -0.526 25.470 1.00 94.37 C \\\\nATOM 133 C TRP A 18 -18.494 -0.673 24.414 1.00 94.37 C \\\\nATOM 134 CB TRP A 18 -20.455 0.728 25.232 1.00 94.37 C \\\\nATOM 135 O TRP A 18 -18.788 -0.656 23.216 1.00 94.37 O \\\\nATOM 136 CG TRP A 18 -21.736 0.776 26.007 1.00 94.37 C \\\\nATOM 137 CD1 TRP A 18 -21.931 1.414 27.182 1.00 94.37 C \\\\nATOM 138 CD2 TRP A 18 -23.021 0.170 25.667 1.00 94.37 C \\\\nATOM 139 CE2 TRP A 18 -23.955 0.477 26.701 1.00 94.37 C \\\\nATOM 140 CE3 TRP A 18 -23.489 -0.612 24.590 1.00 94.37 C \\\\nATOM 141 NE1 TRP A 18 -23.237 1.240 27.597 1.00 94.37 N \\\\nATOM 142 CH2 TRP A 18 -25.718 -0.746 25.586 1.00 94.37 C \\\\nATOM 143 CZ2 TRP A 18 -25.283 0.029 26.674 1.00 94.37 C \\\\nATOM 144 CZ3 TRP A 18 -24.821 -1.071 24.553 1.00 94.37 C \\\\nATOM 145 N LYS A 19 -17.220 -0.789 24.822 1.00 93.60 N \\\\nATOM 146 CA LYS A 19 -16.084 -0.967 23.904 1.00 93.60 C \\\\nATOM 147 C LYS A 19 -16.252 -2.261 23.100 1.00 93.60 C \\\\nATOM 148 CB LYS A 19 -14.760 -0.988 24.693 1.00 93.60 C \\\\nATOM 149 O LYS A 19 -16.579 -3.304 23.660 1.00 93.60 O \\\\nATOM 150 CG LYS A 19 -13.503 -0.930 23.802 1.00 93.60 C \\\\nATOM 151 CD LYS A 19 -12.226 -1.437 24.497 1.00 93.60 C \\\\nATOM 152 CE LYS A 19 -12.183 -2.968 24.676 1.00 93.60 C \\\\nATOM 153 NZ LYS A 19 -11.800 -3.697 23.436 1.00 93.60 N \\\\nATOM 154 N LYS A 20 -15.966 -2.216 21.800 1.00 91.32 N \\\\nATOM 155 CA LYS A 20 -15.914 -3.401 20.929 1.00 91.32 C \\\\nATOM 156 C LYS A 20 -14.490 -3.979 20.863 1.00 91.32 C \\\\nATOM 157 CB LYS A 20 -16.505 -3.040 19.552 1.00 91.32 C \\\\nATOM 158 O LYS A 20 -13.519 -3.312 21.226 1.00 91.32 O \\\\nATOM 159 CG LYS A 20 -17.955 -2.527 19.601 1.00 91.32 C \\\\nATOM 160 CD LYS A 20 -18.979 -3.550 20.111 1.00 91.32 C \\\\nATOM 161 CE LYS A 20 -20.374 -2.919 20.037 1.00 91.32 C \\\\nATOM 162 NZ LYS A 20 -21.437 -3.873 20.436 1.00 91.32 N \\\\nATOM 163 N GLY A 21 -14.358 -5.219 20.397 1.00 81.67 N \\\\nATOM 164 CA GLY A 21 -13.065 -5.891 20.200 1.00 81.67 C \\\\nATOM 165 C GLY A 21 -12.430 -6.446 21.479 1.00 81.67 C \\\\nATOM 166 O GLY A 21 -12.852 -6.136 22.595 1.00 81.67 O \\\\nATOM 167 N GLU A 22 -11.402 -7.268 21.296 1.00 73.16 N \\\\nATOM 168 CA GLU A 22 -10.807 -8.129 22.325 1.00 73.16 C \\\\nATOM 169 C GLU A 22 -10.076 -7.372 23.455 1.00 73.16 C \\\\nATOM 170 CB GLU A 22 -9.896 -9.162 21.638 1.00 73.16 C \\\\nATOM 171 O GLU A 22 -9.916 -6.143 23.435 1.00 73.16 O \\\\nATOM 172 CG GLU A 22 -10.687 -10.037 20.647 1.00 73.16 C \\\\nATOM 173 CD GLU A 22 -9.842 -11.154 20.025 1.00 73.16 C \\\\nATOM 174 OE1 GLU A 22 -10.462 -12.159 19.619 1.00 73.16 O \\\\nATOM 175 OE2 GLU A 22 -8.606 -10.975 19.959 1.00 73.16 O \\\\nATOM 176 N GLN A 23 -9.677 -8.115 24.493 1.00 63.69 N \\\\nATOM 177 CA GLN A 23 -9.051 -7.596 25.714 1.00 63.69 C \\\\nATOM 178 C GLN A 23 -7.518 -7.703 25.659 1.00 63.69 C \\\\nATOM 179 CB GLN A 23 -9.645 -8.273 26.962 1.00 63.69 C \\\\nATOM 180 O GLN A 23 -6.890 -8.444 26.413 1.00 63.69 O \\\\nATOM 181 CG GLN A 23 -11.129 -7.933 27.172 1.00 63.69 C \\\\nATOM 182 CD GLN A 23 -11.699 -8.529 28.459 1.00 63.69 C \\\\nATOM 183 NE2 GLN A 23 -13.005 -8.607 28.586 1.00 63.69 N \\\\nATOM 184 OE1 GLN A 23 -11.010 -8.940 29.374 1.00 63.69 O \\\\nATOM 185 N ASN A 24 -6.894 -6.916 24.782 1.00 71.71 N \\\\nATOM 186 CA ASN A 24 -5.439 -6.776 24.752 1.00 71.71 C \\\\nATOM 187 C ASN A 24 -4.978 -5.762 25.814 1.00 71.71 C \\\\nATOM 188 CB ASN A 24 -5.008 -6.406 23.321 1.00 71.71 C \\\\nATOM 189 O ASN A 24 -5.207 -4.560 25.680 1.00 71.71 O \\\\nATOM 190 CG ASN A 24 -5.145 -7.581 22.369 1.00 71.71 C \\\\nATOM 191 ND2 ASN A 24 -5.467 -7.332 21.123 1.00 71.71 N \\\\nATOM 192 OD1 ASN A 24 -4.943 -8.719 22.744 1.00 71.71 O \\\\nATOM 193 N GLY A 25 -4.286 -6.210 26.868 1.00 75.50 N \\\\nATOM 194 CA GLY A 25 -4.008 -5.386 28.061 1.00 75.50 C \\\\nATOM 195 C GLY A 25 -3.187 -4.097 27.844 1.00 75.50 C \\\\nATOM 196 O GLY A 25 -3.244 -3.176 28.665 1.00 75.50 O \\\\nATOM 197 N GLN A 26 -2.430 -3.977 26.746 1.00 77.51 N \\\\nATOM 198 CA GLN A 26 -1.778 -2.713 26.361 1.00 77.51 C \\\\nATOM 199 C GLN A 26 -2.749 -1.751 25.656 1.00 77.51 C \\\\nATOM 200 CB GLN A 26 -0.555 -3.004 25.477 1.00 77.51 C \\\\nATOM 201 O GLN A 26 -2.683 -0.536 25.861 1.00 77.51 O \\\\nATOM 202 CG GLN A 26 0.283 -1.736 25.216 1.00 77.51 C \\\\nATOM 203 CD GLN A 26 1.514 -1.993 24.352 1.00 77.51 C \\\\nATOM 204 NE2 GLN A 26 2.425 -1.051 24.240 1.00 77.51 N \\\\nATOM 205 OE1 GLN A 26 1.687 -3.027 23.745 1.00 77.51 O \\\\nATOM 206 N GLU A 27 -3.650 -2.291 24.839 1.00 83.83 N \\\\nATOM 207 CA GLU A 27 -4.675 -1.543 24.116 1.00 83.83 C \\\\nATOM 208 C GLU A 27 -5.765 -1.040 25.064 1.00 83.83 C \\\\nATOM 209 CB GLU A 27 -5.237 -2.448 23.019 1.00 83.83 C \\\\nATOM 210 O GLU A 27 -6.132 0.131 25.007 1.00 83.83 O \\\\nATOM 211 CG GLU A 27 -6.292 -1.739 22.170 1.00 83.83 C \\\\nATOM 212 CD GLU A 27 -6.606 -2.516 20.890 1.00 83.83 C \\\\nATOM 213 OE1 GLU A 27 -6.997 -1.820 19.927 1.00 83.83 O \\\\nATOM 214 OE2 GLU A 27 -6.412 -3.753 20.889 1.00 83.83 O \\\\nATOM 215 N GLU A 28 -6.189 -1.861 26.023 1.00 86.39 N \\\\nATOM 216 CA GLU A 28 -7.170 -1.496 27.046 1.00 86.39 C \\\\nATOM 217 C GLU A 28 -6.731 -0.262 27.858 1.00 86.39 C \\\\nATOM 218 CB GLU A 28 -7.381 -2.720 27.939 1.00 86.39 C \\\\nATOM 219 O GLU A 28 -7.491 0.700 28.008 1.00 86.39 O \\\\nATOM 220 CG GLU A 28 -8.544 -2.503 28.910 1.00 86.39 C \\\\nATOM 221 CD GLU A 28 -8.803 -3.737 29.776 1.00 86.39 C \\\\nATOM 222 OE1 GLU A 28 -9.988 -3.932 30.119 1.00 86.39 O \\\\nATOM 223 OE2 GLU A 28 -7.809 -4.416 30.120 1.00 86.39 O \\\\nATOM 224 N LYS A 29 -5.456 -0.210 28.275 1.00 89.47 N \\\\nATOM 225 CA LYS A 29 -4.847 0.972 28.919 1.00 89.47 C \\\\nATOM 226 C LYS A 29 -4.855 2.214 28.021 1.00 89.47 C \\\\nATOM 227 CB LYS A 29 -3.401 0.651 29.334 1.00 89.47 C \\\\nATOM 228 O LYS A 29 -4.849 3.338 28.529 1.00 89.47 O \\\\nATOM 229 CG LYS A 29 -3.332 -0.299 30.536 1.00 89.47 C \\\\nATOM 230 CD LYS A 29 -1.881 -0.697 30.847 1.00 89.47 C \\\\nATOM 231 CE LYS A 29 -1.878 -1.706 32.000 1.00 89.47 C \\\\nATOM 232 NZ LYS A 29 -0.524 -2.251 32.277 1.00 89.47 N \\\\nATOM 233 N TRP A 30 -4.836 2.050 26.699 1.00 92.08 N \\\\nATOM 234 CA TRP A 30 -4.953 3.163 25.757 1.00 92.08 C \\\\nATOM 235 C TRP A 30 -6.415 3.594 25.561 1.00 92.08 C \\\\nATOM 236 CB TRP A 30 -4.245 2.826 24.440 1.00 92.08 C \\\\nATOM 237 O TRP A 30 -6.694 4.792 25.632 1.00 92.08 O \\\\nATOM 238 CG TRP A 30 -4.246 3.969 23.477 1.00 92.08 C \\\\nATOM 239 CD1 TRP A 30 -3.329 4.961 23.418 1.00 92.08 C \\\\nATOM 240 CD2 TRP A 30 -5.266 4.301 22.489 1.00 92.08 C \\\\nATOM 241 CE2 TRP A 30 -4.898 5.529 21.862 1.00 92.08 C \\\\nATOM 242 CE3 TRP A 30 -6.468 3.691 22.071 1.00 92.08 C \\\\nATOM 243 NE1 TRP A 30 -3.720 5.898 22.481 1.00 92.08 N \\\\nATOM 244 CH2 TRP A 30 -6.859 5.472 20.450 1.00 92.08 C \\\\nATOM 245 CZ2 TRP A 30 -5.674 6.113 20.851 1.00 92.08 C \\\\nATOM 246 CZ3 TRP A 30 -7.259 4.273 21.064 1.00 92.08 C \\\\nATOM 247 N CYS A 31 -7.352 2.652 25.423 1.00 93.06 N \\\\nATOM 248 CA CYS A 31 -8.793 2.918 25.376 1.00 93.06 C \\\\nATOM 249 C CYS A 31 -9.267 3.664 26.631 1.00 93.06 C \\\\nATOM 250 CB CYS A 31 -9.547 1.589 25.225 1.00 93.06 C \\\\nATOM 251 O CYS A 31 -9.973 4.667 26.526 1.00 93.06 O \\\\nATOM 252 SG CYS A 31 -9.173 0.837 23.618 1.00 93.06 S \\\\nATOM 253 N GLU A 32 -8.811 3.253 27.818 1.00 93.85 N \\\\nATOM 254 CA GLU A 32 -9.129 3.942 29.068 1.00 93.85 C \\\\nATOM 255 C GLU A 32 -8.646 5.403 29.051 1.00 93.85 C \\\\nATOM 256 CB GLU A 32 -8.528 3.173 30.256 1.00 93.85 C \\\\nATOM 257 O GLU A 32 -9.396 6.315 29.410 1.00 93.85 O \\\\nATOM 258 CG GLU A 32 -9.135 3.703 31.560 1.00 93.85 C \\\\nATOM 259 CD GLU A 32 -8.376 3.311 32.819 1.00 93.85 C \\\\nATOM 260 OE1 GLU A 32 -9.063 3.201 33.856 1.00 93.85 O \\\\nATOM 261 OE2 GLU A 32 -7.156 3.567 32.892 1.00 93.85 O \\\\nATOM 262 N LYS A 33 -7.422 5.662 28.568 1.00 94.20 N \\\\nATOM 263 CA LYS A 33 -6.902 7.028 28.384 1.00 94.20 C \\\\nATOM 264 C LYS A 33 -7.714 7.822 27.350 1.00 94.20 C \\\\nATOM 265 CB LYS A 33 -5.416 6.983 27.997 1.00 94.20 C \\\\nATOM 266 O LYS A 33 -7.950 9.012 27.570 1.00 94.20 O \\\\nATOM 267 CG LYS A 33 -4.493 6.589 29.163 1.00 94.20 C \\\\nATOM 268 CD LYS A 33 -3.055 6.448 28.644 1.00 94.20 C \\\\nATOM 269 CE LYS A 33 -2.055 6.087 29.746 1.00 94.20 C \\\\nATOM 270 NZ LYS A 33 -0.678 5.970 29.197 1.00 94.20 N \\\\nATOM 271 N ALA A 34 -8.168 7.195 26.262 1.00 95.40 N \\\\nATOM 272 CA ALA A 34 -8.990 7.833 25.229 1.00 95.40 C \\\\nATOM 273 C ALA A 34 -10.354 8.286 25.776 1.00 95.40 C \\\\nATOM 274 CB ALA A 34 -9.158 6.870 24.043 1.00 95.40 C \\\\nATOM 275 O ALA A 34 -10.758 9.432 25.550 1.00 95.40 O \\\\nATOM 276 N VAL A 35 -11.025 7.426 26.551 1.00 96.53 N \\\\nATOM 277 CA VAL A 35 -12.314 7.731 27.196 1.00 96.53 C \\\\nATOM 278 C VAL A 35 -12.135 8.746 28.331 1.00 96.53 C \\\\nATOM 279 CB VAL A 35 -13.021 6.443 27.671 1.00 96.53 C \\\\nATOM 280 O VAL A 35 -12.880 9.723 28.382 1.00 96.53 O \\\\nATOM 281 CG1 VAL A 35 -14.354 6.736 28.371 1.00 96.53 C \\\\nATOM 282 CG2 VAL A 35 -13.342 5.528 26.481 1.00 96.53 C \\\\nATOM 283 N LYS A 36 -11.109 8.614 29.189 1.00 95.17 N \\\\nATOM 284 CA LYS A 36 -10.775 9.626 30.220 1.00 95.17 C \\\\nATOM 285 C LYS A 36 -10.539 11.013 29.600 1.00 95.17 C \\\\nATOM 286 CB LYS A 36 -9.550 9.177 31.053 1.00 95.17 C \\\\nATOM 287 O LYS A 36 -11.017 12.011 30.141 1.00 95.17 O \\\\nATOM 288 CG LYS A 36 -9.892 8.090 32.090 1.00 95.17 C \\\\nATOM 289 CD LYS A 36 -8.669 7.513 32.836 1.00 95.17 C \\\\nATOM 290 CE LYS A 36 -9.134 6.505 33.906 1.00 95.17 C \\\\nATOM 291 NZ LYS A 36 -8.036 5.721 34.536 1.00 95.17 N \\\\nATOM 292 N SER A 37 -9.846 11.077 28.460 1.00 94.09 N \\\\nATOM 293 CA SER A 37 -9.610 12.319 27.710 1.00 94.09 C \\\\nATOM 294 C SER A 37 -10.909 12.918 27.155 1.00 94.09 C \\\\nATOM 295 CB SER A 37 -8.606 12.064 26.581 1.00 94.09 C \\\\nATOM 296 O SER A 37 -11.152 14.114 27.340 1.00 94.09 O \\\\nATOM 297 OG SER A 37 -8.200 13.280 25.982 1.00 94.09 O \\\\nATOM 298 N LEU A 38 -11.783 12.096 26.554 1.00 96.68 N \\\\nATOM 299 CA LEU A 38 -13.076 12.562 26.040 1.00 96.68 C \\\\nATOM 300 C LEU A 38 -13.976 13.088 27.158 1.00 96.68 C \\\\nATOM 301 CB LEU A 38 -13.802 11.447 25.269 1.00 96.68 C \\\\nATOM 302 O LEU A 38 -14.448 14.217 27.080 1.00 96.68 O \\\\nATOM 303 CG LEU A 38 -15.076 11.947 24.555 1.00 96.68 C \\\\nATOM 304 CD1 LEU A 38 -14.806 13.050 23.532 1.00 96.68 C \\\\nATOM 305 CD2 LEU A 38 -15.755 10.790 23.841 1.00 96.68 C \\\\nATOM 306 N VAL A 39 -14.156 12.316 28.232 1.00 96.49 N \\\\nATOM 307 CA VAL A 39 -14.986 12.708 29.382 1.00 96.49 C \\\\nATOM 308 C VAL A 39 -14.498 14.033 29.979 1.00 96.49 C \\\\nATOM 309 CB VAL A 39 -15.018 11.573 30.428 1.00 96.49 C \\\\nATOM 310 O VAL A 39 -15.314 14.888 30.311 1.00 96.49 O \\\\nATOM 311 CG1 VAL A 39 -15.682 11.974 31.753 1.00 96.49 C \\\\nATOM 312 CG2 VAL A 39 -15.792 10.365 29.885 1.00 96.49 C \\\\nATOM 313 N LYS A 40 -13.179 14.271 30.054 1.00 94.22 N \\\\nATOM 314 CA LYS A 40 -12.625 15.559 30.512 1.00 94.22 C \\\\nATOM 315 C LYS A 40 -12.964 16.731 29.576 1.00 94.22 C \\\\nATOM 316 CB LYS A 40 -11.106 15.419 30.726 1.00 94.22 C \\\\nATOM 317 O LYS A 40 -13.098 17.851 30.064 1.00 94.22 O \\\\nATOM 318 CG LYS A 40 -10.491 16.668 31.386 1.00 94.22 C \\\\nATOM 319 CD LYS A 40 -8.990 16.506 31.663 1.00 94.22 C \\\\nATOM 320 CE LYS A 40 -8.447 17.779 32.331 1.00 94.22 C \\\\nATOM 321 NZ LYS A 40 -6.997 17.680 32.651 1.00 94.22 N \\\\nATOM 322 N LYS A 41 -13.090 16.499 28.263 1.00 94.36 N \\\\nATOM 323 CA LYS A 41 -13.530 17.509 27.283 1.00 94.36 C \\\\nATOM 324 C LYS A 41 -15.037 17.759 27.391 1.00 94.36 C \\\\nATOM 325 CB LYS A 41 -13.121 17.098 25.856 1.00 94.36 C \\\\nATOM 326 O LYS A 41 -15.428 18.897 27.622 1.00 94.36 O \\\\nATOM 327 CG LYS A 41 -11.608 17.217 25.604 1.00 94.36 C \\\\nATOM 328 CD LYS A 41 -11.234 16.547 24.272 1.00 94.36 C \\\\nATOM 329 CE LYS A 41 -9.768 16.770 23.874 1.00 94.36 C \\\\nATOM 330 NZ LYS A 41 -9.555 18.101 23.243 1.00 94.36 N \\\\nATOM 331 N LEU A 42 -15.862 16.712 27.337 1.00 96.39 N \\\\nATOM 332 CA LEU A 42 -17.328 16.840 27.334 1.00 96.39 C \\\\nATOM 333 C LEU A 42 -17.905 17.358 28.660 1.00 96.39 C \\\\nATOM 334 CB LEU A 42 -17.979 15.506 26.942 1.00 96.39 C \\\\nATOM 335 O LEU A 42 -18.942 18.012 28.663 1.00 96.39 O \\\\nATOM 336 CG LEU A 42 -17.544 14.942 25.578 1.00 96.39 C \\\\nATOM 337 CD1 LEU A 42 -18.333 13.665 25.325 1.00 96.39 C \\\\nATOM 338 CD2 LEU A 42 -17.753 15.890 24.400 1.00 96.39 C \\\\nATOM 339 N LYS A 43 -17.206 17.166 29.789 1.00 94.30 N \\\\nATOM 340 CA LYS A 43 -17.544 17.844 31.055 1.00 94.30 C \\\\nATOM 341 C LYS A 43 -17.469 19.373 30.981 1.00 94.30 C \\\\nATOM 342 CB LYS A 43 -16.642 17.354 32.200 1.00 94.30 C \\\\nATOM 343 O LYS A 43 -18.084 20.024 31.814 1.00 94.30 O \\\\nATOM 344 CG LYS A 43 -17.148 16.032 32.779 1.00 94.30 C \\\\nATOM 345 CD LYS A 43 -16.408 15.665 34.067 1.00 94.30 C \\\\nATOM 346 CE LYS A 43 -17.047 14.403 34.653 1.00 94.30 C \\\\nATOM 347 NZ LYS A 43 -16.722 14.247 36.092 1.00 94.30 N \\\\nATOM 348 N LYS A 44 -16.711 19.943 30.036 1.00 92.38 N \\\\nATOM 349 CA LYS A 44 -16.640 21.398 29.828 1.00 92.38 C \\\\nATOM 350 C LYS A 44 -17.732 21.922 28.893 1.00 92.38 C \\\\nATOM 351 CB LYS A 44 -15.269 21.811 29.280 1.00 92.38 C \\\\nATOM 352 O LYS A 44 -18.091 23.083 29.018 1.00 92.38 O \\\\nATOM 353 CG LYS A 44 -14.102 21.511 30.230 1.00 92.38 C \\\\nATOM 354 CD LYS A 44 -12.836 22.153 29.652 1.00 92.38 C \\\\nATOM 355 CE LYS A 44 -11.666 22.080 30.633 1.00 92.38 C \\\\nATOM 356 NZ LYS A 44 -10.614 23.058 30.251 1.00 92.38 N \\\\nATOM 357 N THR A 45 -18.227 21.093 27.971 1.00 92.89 N \\\\nATOM 358 CA THR A 45 -19.252 21.469 26.979 1.00 92.89 C \\\\nATOM 359 C THR A 45 -20.670 21.042 27.372 1.00 92.89 C \\\\nATOM 360 CB THR A 45 -18.919 20.901 25.588 1.00 92.89 C \\\\nATOM 361 O THR A 45 -21.625 21.418 26.705 1.00 92.89 O \\\\nATOM 362 CG2 THR A 45 -17.564 21.381 25.065 1.00 92.89 C \\\\nATOM 363 OG1 THR A 45 -18.867 19.493 25.628 1.00 92.89 O \\\\nATOM 364 N GLY A 46 -20.830 20.240 28.431 1.00 94.57 N \\\\nATOM 365 CA GLY A 46 -22.132 19.732 28.886 1.00 94.57 C \\\\nATOM 366 C GLY A 46 -22.679 18.545 28.078 1.00 94.57 C \\\\nATOM 367 O GLY A 46 -23.735 18.020 28.403 1.00 94.57 O \\\\nATOM 368 N GLN A 47 -21.958 18.059 27.064 1.00 96.14 N \\\\nATOM 369 CA GLN A 47 -22.416 16.991 26.154 1.00 96.14 C \\\\nATOM 370 C GLN A 47 -22.206 15.561 26.691 1.00 96.14 C \\\\nATOM 371 CB GLN A 47 -21.702 17.166 24.809 1.00 96.14 C \\\\nATOM 372 O GLN A 47 -22.330 14.589 25.945 1.00 96.14 O \\\\nATOM 373 CG GLN A 47 -22.141 18.419 24.037 1.00 96.14 C \\\\nATOM 374 CD GLN A 47 -21.126 18.755 22.955 1.00 96.14 C \\\\nATOM 375 NE2 GLN A 47 -21.521 18.931 21.715 1.00 96.14 N \\\\nATOM 376 OE1 GLN A 47 -19.939 18.835 23.226 1.00 96.14 O \\\\nATOM 377 N LEU A 48 -21.836 15.397 27.964 1.00 95.75 N \\\\nATOM 378 CA LEU A 48 -21.485 14.086 28.519 1.00 95.75 C \\\\nATOM 379 C LEU A 48 -22.686 13.127 28.579 1.00 95.75 C \\\\nATOM 380 CB LEU A 48 -20.831 14.306 29.891 1.00 95.75 C \\\\nATOM 381 O LEU A 48 -22.535 11.949 28.255 1.00 95.75 O \\\\nATOM 382 CG LEU A 48 -20.337 13.019 30.577 1.00 95.75 C \\\\nATOM 383 CD1 LEU A 48 -19.330 12.230 29.733 1.00 95.75 C \\\\nATOM 384 CD2 LEU A 48 -19.630 13.420 31.875 1.00 95.75 C \\\\nATOM 385 N ASP A 49 -23.866 13.642 28.922 1.00 95.20 N \\\\nATOM 386 CA ASP A 49 -25.095 12.846 29.016 1.00 95.20 C \\\\nATOM 387 C ASP A 49 -25.645 12.495 27.624 1.00 95.20 C \\\\nATOM 388 CB ASP A 49 -26.134 13.605 29.858 1.00 95.20 C \\\\nATOM 389 O ASP A 49 -26.134 11.388 27.407 1.00 95.20 O \\\\nATOM 390 CG ASP A 49 -25.631 13.965 31.265 1.00 95.20 C \\\\nATOM 391 OD1 ASP A 49 -24.765 13.233 31.800 1.00 95.20 O \\\\nATOM 392 OD2 ASP A 49 -26.072 15.015 31.774 1.00 95.20 O \\\\nATOM 393 N GLU A 50 -25.483 13.388 26.638 1.00 95.50 N \\\\nATOM 394 CA GLU A 50 -25.808 13.097 25.234 1.00 95.50 C \\\\nATOM 395 C GLU A 50 -24.863 12.031 24.649 1.00 95.50 C \\\\nATOM 396 CB GLU A 50 -25.787 14.382 24.385 1.00 95.50 C \\\\nATOM 397 O GLU A 50 -25.313 11.192 23.870 1.00 95.50 O \\\\nATOM 398 CG GLU A 50 -26.900 15.395 24.714 1.00 95.50 C \\\\nATOM 399 CD GLU A 50 -28.309 15.049 24.181 1.00 95.50 C \\\\nATOM 400 OE1 GLU A 50 -29.188 15.943 24.269 1.00 95.50 O \\\\nATOM 401 OE2 GLU A 50 -28.551 13.943 23.643 1.00 95.50 O \\\\nATOM 402 N LEU A 51 -23.579 11.987 25.051 1.00 96.84 N \\\\nATOM 403 CA LEU A 51 -22.690 10.876 24.681 1.00 96.84 C \\\\nATOM 404 C LEU A 51 -23.177 9.565 25.306 1.00 96.84 C \\\\nATOM 405 CB LEU A 51 -21.223 11.158 25.072 1.00 96.84 C \\\\nATOM 406 O LEU A 51 -23.258 8.559 24.608 1.00 96.84 O \\\\nATOM 407 CG LEU A 51 -20.286 9.951 24.816 1.00 96.84 C \\\\nATOM 408 CD1 LEU A 51 -20.083 9.664 23.326 1.00 96.84 C \\\\nATOM 409 CD2 LEU A 51 -18.912 10.170 25.444 1.00 96.84 C \\\\nATOM 410 N GLU A 52 -23.492 9.552 26.604 1.00 95.89 N \\\\nATOM 411 CA GLU A 52 -23.990 8.338 27.260 1.00 95.89 C \\\\nATOM 412 C GLU A 52 -25.289 7.842 26.603 1.00 95.89 C \\\\nATOM 413 CB GLU A 52 -24.130 8.559 28.777 1.00 95.89 C \\\\nATOM 414 O GLU A 52 -25.407 6.653 26.302 1.00 95.89 O \\\\nATOM 415 CG GLU A 52 -24.640 7.275 29.454 1.00 95.89 C \\\\nATOM 416 CD GLU A 52 -24.390 7.180 30.966 1.00 95.89 C \\\\nATOM 417 OE1 GLU A 52 -24.482 6.043 31.488 1.00 95.89 O \\\\nATOM 418 OE2 GLU A 52 -24.034 8.174 31.642 1.00 95.89 O \\\\nATOM 419 N LYS A 53 -26.214 8.750 26.274 1.00 96.28 N \\\\nATOM 420 CA LYS A 53 -27.424 8.464 25.493 1.00 96.28 C \\\\nATOM 421 C LYS A 53 -27.110 7.912 24.098 1.00 96.28 C \\\\nATOM 422 CB LYS A 53 -28.249 9.752 25.426 1.00 96.28 C \\\\nATOM 423 O LYS A 53 -27.704 6.910 23.710 1.00 96.28 O \\\\nATOM 424 CG LYS A 53 -29.588 9.592 24.694 1.00 96.28 C \\\\nATOM 425 CD LYS A 53 -30.278 10.958 24.673 1.00 96.28 C \\\\nATOM 426 CE LYS A 53 -31.551 10.955 23.829 1.00 96.28 C \\\\nATOM 427 NZ LYS A 53 -32.033 12.348 23.670 1.00 96.28 N \\\\nATOM 428 N ALA A 54 -26.183 8.509 23.347 1.00 96.62 N \\\\nATOM 429 CA ALA A 54 -25.789 8.024 22.020 1.00 96.62 C \\\\nATOM 430 C ALA A 54 -25.207 6.605 22.072 1.00 96.62 C \\\\nATOM 431 CB ALA A 54 -24.807 9.023 21.396 1.00 96.62 C \\\\nATOM 432 O ALA A 54 -25.616 5.742 21.298 1.00 96.62 O \\\\nATOM 433 N ILE A 55 -24.307 6.335 23.022 1.00 96.30 N \\\\nATOM 434 CA ILE A 55 -23.681 5.018 23.186 1.00 96.30 C \\\\nATOM 435 C ILE A 55 -24.688 3.949 23.637 1.00 96.30 C \\\\nATOM 436 CB ILE A 55 -22.447 5.125 24.110 1.00 96.30 C \\\\nATOM 437 O ILE A 55 -24.665 2.845 23.099 1.00 96.30 O \\\\nATOM 438 CG1 ILE A 55 -21.331 6.033 23.539 1.00 96.30 C \\\\nATOM 439 CG2 ILE A 55 -21.849 3.744 24.414 1.00 96.30 C \\\\nATOM 440 CD1 ILE A 55 -20.863 5.722 22.113 1.00 96.30 C \\\\nATOM 441 N THR A 56 -25.581 4.270 24.577 1.00 95.54 N \\\\nATOM 442 CA THR A 56 -26.559 3.307 25.119 1.00 95.54 C \\\\nATOM 443 C THR A 56 -27.722 3.023 24.169 1.00 95.54 C \\\\nATOM 444 CB THR A 56 -27.124 3.769 26.470 1.00 95.54 C \\\\nATOM 445 O THR A 56 -28.125 1.871 24.038 1.00 95.54 O \\\\nATOM 446 CG2 THR A 56 -26.083 3.724 27.588 1.00 95.54 C \\\\nATOM 447 OG1 THR A 56 -27.596 5.093 26.403 1.00 95.54 O \\\\nATOM 448 N THR A 57 -28.254 4.044 23.488 1.00 95.70 N \\\\nATOM 449 CA THR A 57 -29.405 3.891 22.573 1.00 95.70 C \\\\nATOM 450 C THR A 57 -29.015 3.477 21.157 1.00 95.70 C \\\\nATOM 451 CB THR A 57 -30.266 5.160 22.486 1.00 95.70 C \\\\nATOM 452 O THR A 57 -29.880 3.040 20.404 1.00 95.70 O \\\\nATOM 453 CG2 THR A 57 -30.814 5.604 23.842 1.00 95.70 C \\\\nATOM 454 OG1 THR A 57 -29.544 6.240 21.937 1.00 95.70 O \\\\nATOM 455 N GLN A 58 -27.740 3.634 20.781 1.00 94.54 N \\\\nATOM 456 CA GLN A 58 -27.207 3.349 19.440 1.00 94.54 C \\\\nATOM 457 C GLN A 58 -27.936 4.101 18.305 1.00 94.54 C \\\\nATOM 458 CB GLN A 58 -27.084 1.828 19.211 1.00 94.54 C \\\\nATOM 459 O GLN A 58 -27.935 3.680 17.149 1.00 94.54 O \\\\nATOM 460 CG GLN A 58 -26.407 1.116 20.396 1.00 94.54 C \\\\nATOM 461 CD GLN A 58 -26.008 -0.329 20.117 1.00 94.54 C \\\\nATOM 462 NE2 GLN A 58 -25.957 -1.152 21.140 1.00 94.54 N \\\\nATOM 463 OE1 GLN A 58 -25.721 -0.762 19.012 1.00 94.54 O \\\\nATOM 464 N ASN A 59 -28.581 5.224 18.639 1.00 92.87 N \\\\nATOM 465 CA ASN A 59 -29.505 5.929 17.759 1.00 92.87 C \\\\nATOM 466 C ASN A 59 -28.807 7.069 16.998 1.00 92.87 C \\\\nATOM 467 CB ASN A 59 -30.705 6.378 18.611 1.00 92.87 C \\\\nATOM 468 O ASN A 59 -28.278 8.009 17.602 1.00 92.87 O \\\\nATOM 469 CG ASN A 59 -31.841 7.012 17.826 1.00 92.87 C \\\\nATOM 470 ND2 ASN A 59 -32.980 7.188 18.452 1.00 92.87 N \\\\nATOM 471 OD1 ASN A 59 -31.741 7.366 16.661 1.00 92.87 O \\\\nATOM 472 N VAL A 60 -28.870 7.013 15.664 1.00 93.35 N \\\\nATOM 473 CA VAL A 60 -28.315 8.020 14.739 1.00 93.35 C \\\\nATOM 474 C VAL A 60 -28.921 9.418 14.934 1.00 93.35 C \\\\nATOM 475 CB VAL A 60 -28.468 7.567 13.270 1.00 93.35 C \\\\nATOM 476 O VAL A 60 -28.242 10.414 14.707 1.00 93.35 O \\\\nATOM 477 CG1 VAL A 60 -27.803 6.203 13.031 1.00 93.35 C \\\\nATOM 478 CG2 VAL A 60 -29.931 7.460 12.812 1.00 93.35 C \\\\nATOM 479 N ASN A 61 -30.156 9.502 15.441 1.00 95.00 N \\\\nATOM 480 CA ASN A 61 -30.888 10.750 15.696 1.00 95.00 C \\\\nATOM 481 C ASN A 61 -30.514 11.426 17.033 1.00 95.00 C \\\\nATOM 482 CB ASN A 61 -32.399 10.475 15.611 1.00 95.00 C \\\\nATOM 483 O ASN A 61 -31.206 12.332 17.498 1.00 95.00 O \\\\nATOM 484 CG ASN A 61 -32.808 9.842 14.297 1.00 95.00 C \\\\nATOM 485 ND2 ASN A 61 -33.213 8.595 14.305 1.00 95.00 N \\\\nATOM 486 OD1 ASN A 61 -32.733 10.444 13.246 1.00 95.00 O \\\\nATOM 487 N THR A 62 -29.454 10.970 17.706 1.00 95.86 N \\\\nATOM 488 CA THR A 62 -28.888 11.690 18.859 1.00 95.86 C \\\\nATOM 489 C THR A 62 -28.145 12.951 18.412 1.00 95.86 C \\\\nATOM 490 CB THR A 62 -28.010 10.785 19.738 1.00 95.86 C \\\\nATOM 491 O THR A 62 -27.816 13.104 17.239 1.00 95.86 O \\\\nATOM 492 CG2 THR A 62 -28.897 9.815 20.518 1.00 95.86 C \\\\nATOM 493 OG1 THR A 62 -27.070 10.038 18.995 1.00 95.86 O \\\\nATOM 494 N LYS A 63 -27.895 13.895 19.330 1.00 96.63 N \\\\nATOM 495 CA LYS A 63 -27.209 15.154 18.992 1.00 96.63 C \\\\nATOM 496 C LYS A 63 -25.744 14.921 18.605 1.00 96.63 C \\\\nATOM 497 CB LYS A 63 -27.314 16.159 20.148 1.00 96.63 C \\\\nATOM 498 O LYS A 63 -25.135 13.909 18.967 1.00 96.63 O \\\\nATOM 499 CG LYS A 63 -28.758 16.609 20.412 1.00 96.63 C \\\\nATOM 500 CD LYS A 63 -28.768 17.696 21.493 1.00 96.63 C \\\\nATOM 501 CE LYS A 63 -30.200 17.996 21.951 1.00 96.63 C \\\\nATOM 502 NZ LYS A 63 -30.233 18.277 23.405 1.00 96.63 N \\\\nATOM 503 N CYS A 64 -25.151 15.889 17.906 1.00 97.45 N \\\\nATOM 504 CA CYS A 64 -23.708 15.899 17.689 1.00 97.45 C \\\\nATOM 505 C CYS A 64 -22.976 16.013 19.035 1.00 97.45 C \\\\nATOM 506 CB CYS A 64 -23.301 17.032 16.736 1.00 97.45 C \\\\nATOM 507 O CYS A 64 -23.277 16.878 19.859 1.00 97.45 O \\\\nATOM 508 SG CYS A 64 -23.929 16.730 15.059 1.00 97.45 S \\\\nATOM 509 N ILE A 65 -21.986 15.145 19.238 1.00 97.88 N \\\\nATOM 510 CA ILE A 65 -21.057 15.214 20.369 1.00 97.88 C \\\\nATOM 511 C ILE A 65 -19.784 15.843 19.833 1.00 97.88 C \\\\nATOM 512 CB ILE A 65 -20.803 13.809 20.959 1.00 97.88 C \\\\nATOM 513 O ILE A 65 -19.086 15.193 19.059 1.00 97.88 O \\\\nATOM 514 CG1 ILE A 65 -22.099 13.076 21.362 1.00 97.88 C \\\\nATOM 515 CG2 ILE A 65 -19.845 13.902 22.156 1.00 97.88 C \\\\nATOM 516 CD1 ILE A 65 -23.002 13.838 22.332 1.00 97.88 C \\\\nATOM 517 N THR A 66 -19.495 17.093 20.178 1.00 97.50 N \\\\nATOM 518 CA THR A 66 -18.403 17.848 19.556 1.00 97.50 C \\\\nATOM 519 C THR A 66 -17.161 17.943 20.436 1.00 97.50 C \\\\nATOM 520 CB THR A 66 -18.853 19.226 19.043 1.00 97.50 C \\\\nATOM 521 O THR A 66 -17.208 17.860 21.663 1.00 97.50 O \\\\nATOM 522 CG2 THR A 66 -19.826 19.092 17.873 1.00 97.50 C \\\\nATOM 523 OG1 THR A 66 -19.484 20.007 20.020 1.00 97.50 O \\\\nATOM 524 N ILE A 67 -16.002 18.076 19.789 1.00 96.58 N \\\\nATOM 525 CA ILE A 67 -14.770 18.550 20.423 1.00 96.58 C \\\\nATOM 526 C ILE A 67 -14.099 19.604 19.526 1.00 96.58 C \\\\nATOM 527 CB ILE A 67 -13.795 17.398 20.776 1.00 96.58 C \\\\nATOM 528 O ILE A 67 -14.213 19.500 18.301 1.00 96.58 O \\\\nATOM 529 CG1 ILE A 67 -13.241 16.667 19.533 1.00 96.58 C \\\\nATOM 530 CG2 ILE A 67 -14.426 16.406 21.772 1.00 96.58 C \\\\nATOM 531 CD1 ILE A 67 -12.138 15.653 19.860 1.00 96.58 C \\\\nATOM 532 N PRO A 68 -13.321 20.546 20.093 1.00 95.38 N \\\\nATOM 533 CA PRO A 68 -12.526 21.483 19.303 1.00 95.38 C \\\\nATOM 534 C PRO A 68 -11.526 20.769 18.386 1.00 95.38 C \\\\nATOM 535 CB PRO A 68 -11.821 22.392 20.315 1.00 95.38 C \\\\nATOM 536 O PRO A 68 -10.821 19.845 18.818 1.00 95.38 O \\\\nATOM 537 CG PRO A 68 -12.757 22.354 21.521 1.00 95.38 C \\\\nATOM 538 CD PRO A 68 -13.292 20.923 21.498 1.00 95.38 C \\\\nATOM 539 N ARG A 69 -11.451 21.219 17.131 1.00 95.13 N \\\\nATOM 540 CA ARG A 69 -10.511 20.757 16.106 1.00 95.13 C \\\\nATOM 541 C ARG A 69 -9.103 21.296 16.394 1.00 95.13 C \\\\nATOM 542 CB ARG A 69 -11.061 21.203 14.735 1.00 95.13 C \\\\nATOM 543 O ARG A 69 -8.932 22.446 16.781 1.00 95.13 O \\\\nATOM 544 CG ARG A 69 -10.229 20.703 13.544 1.00 95.13 C \\\\nATOM 545 CD ARG A 69 -10.828 21.090 12.187 1.00 95.13 C \\\\nATOM 546 NE ARG A 69 -12.138 20.456 11.968 1.00 95.13 N \\\\nATOM 547 NH1 ARG A 69 -11.563 18.720 10.567 1.00 95.13 N \\\\nATOM 548 NH2 ARG A 69 -13.693 19.061 11.108 1.00 95.13 N \\\\nATOM 549 CZ ARG A 69 -12.449 19.415 11.226 1.00 95.13 C \\\\nATOM 550 N SER A 70 -8.076 20.463 16.218 1.00 93.69 N \\\\nATOM 551 CA SER A 70 -6.675 20.911 16.235 1.00 93.69 C \\\\nATOM 552 C SER A 70 -6.253 21.450 14.865 1.00 93.69 C \\\\nATOM 553 CB SER A 70 -5.742 19.766 16.648 1.00 93.69 C \\\\nATOM 554 O SER A 70 -6.850 21.094 13.851 1.00 93.69 O \\\\nATOM 555 OG SER A 70 -5.823 18.716 15.711 1.00 93.69 O \\\\nATOM 556 N LEU A 71 -5.163 22.222 14.818 1.00 90.27 N \\\\nATOM 557 CA LEU A 71 -4.580 22.745 13.570 1.00 90.27 C \\\\nATOM 558 C LEU A 71 -4.316 21.657 12.507 1.00 90.27 C \\\\nATOM 559 CB LEU A 71 -3.256 23.464 13.900 1.00 90.27 C \\\\nATOM 560 O LEU A 71 -4.434 21.918 11.318 1.00 90.27 O \\\\nATOM 561 CG LEU A 71 -3.372 24.686 14.832 1.00 90.27 C \\\\nATOM 562 CD1 LEU A 71 -1.974 25.203 15.173 1.00 90.27 C \\\\nATOM 563 CD2 LEU A 71 -4.171 25.824 14.201 1.00 90.27 C \\\\nATOM 564 N ASP A 72 -3.990 20.431 12.932 1.00 89.02 N \\\\nATOM 565 CA ASP A 72 -3.747 19.272 12.060 1.00 89.02 C \\\\nATOM 566 C ASP A 72 -4.926 18.276 11.996 1.00 89.02 C \\\\nATOM 567 CB ASP A 72 -2.433 18.589 12.485 1.00 89.02 C \\\\nATOM 568 O ASP A 72 -4.781 17.172 11.472 1.00 89.02 O \\\\nATOM 569 CG ASP A 72 -2.514 17.778 13.788 1.00 89.02 C \\\\nATOM 570 OD1 ASP A 72 -3.458 17.970 14.592 1.00 89.02 O \\\\nATOM 571 OD2 ASP A 72 -1.606 16.927 13.988 1.00 89.02 O \\\\nATOM 572 N GLY A 73 -6.075 18.615 12.589 1.00 90.68 N \\\\nATOM 573 CA GLY A 73 -7.268 17.767 12.680 1.00 90.68 C \\\\nATOM 574 C GLY A 73 -7.142 16.496 13.539 1.00 90.68 C \\\\nATOM 575 O GLY A 73 -8.121 15.751 13.646 1.00 90.68 O \\\\nATOM 576 N ARG A 74 -5.982 16.216 14.152 1.00 92.97 N \\\\nATOM 577 CA ARG A 74 -5.710 14.993 14.927 1.00 92.97 C \\\\nATOM 578 C ARG A 74 -5.775 15.211 16.439 1.00 92.97 C \\\\nATOM 579 CB ARG A 74 -4.347 14.404 14.541 1.00 92.97 C \\\\nATOM 580 O ARG A 74 -5.153 16.105 17.007 1.00 92.97 O \\\\nATOM 581 CG ARG A 74 -4.292 13.941 13.076 1.00 92.97 C \\\\nATOM 582 CD ARG A 74 -2.922 13.364 12.704 1.00 92.97 C \\\\nATOM 583 NE ARG A 74 -1.854 14.364 12.867 1.00 92.97 N \\\\nATOM 584 NH1 ARG A 74 -0.127 13.265 11.816 1.00 92.97 N \\\\nATOM 585 NH2 ARG A 74 0.142 15.350 12.593 1.00 92.97 N \\\\nATOM 586 CZ ARG A 74 -0.619 14.312 12.419 1.00 92.97 C \\\\nATOM 587 N LEU A 75 -6.436 14.284 17.124 1.00 94.38 N \\\\nATOM 588 CA LEU A 75 -6.420 14.175 18.577 1.00 94.38 C \\\\nATOM 589 C LEU A 75 -5.216 13.339 19.036 1.00 94.38 C \\\\nATOM 590 CB LEU A 75 -7.766 13.584 19.026 1.00 94.38 C \\\\nATOM 591 O LEU A 75 -4.989 12.231 18.547 1.00 94.38 O \\\\nATOM 592 CG LEU A 75 -7.917 13.386 20.543 1.00 94.38 C \\\\nATOM 593 CD1 LEU A 75 -7.888 14.711 21.312 1.00 94.38 C \\\\nATOM 594 CD2 LEU A 75 -9.250 12.703 20.838 1.00 94.38 C \\\\nATOM 595 N GLN A 76 -4.470 13.843 20.021 1.00 93.91 N \\\\nATOM 596 CA GLN A 76 -3.434 13.075 20.711 1.00 93.91 C \\\\nATOM 597 C GLN A 76 -4.001 12.383 21.959 1.00 93.91 C \\\\nATOM 598 CB GLN A 76 -2.228 13.973 21.025 1.00 93.91 C \\\\nATOM 599 O GLN A 76 -4.605 13.023 22.821 1.00 93.91 O \\\\nATOM 600 CG GLN A 76 -1.059 13.148 21.595 1.00 93.91 C \\\\nATOM 601 CD GLN A 76 0.254 13.919 21.672 1.00 93.91 C \\\\nATOM 602 NE2 GLN A 76 1.165 13.490 22.517 1.00 93.91 N \\\\nATOM 603 OE1 GLN A 76 0.496 14.875 20.951 1.00 93.91 O \\\\nATOM 604 N VAL A 77 -3.755 11.077 22.078 1.00 91.95 N \\\\nATOM 605 CA VAL A 77 -4.080 10.257 23.252 1.00 91.95 C \\\\nATOM 606 C VAL A 77 -2.822 9.505 23.690 1.00 91.95 C \\\\nATOM 607 CB VAL A 77 -5.244 9.286 22.969 1.00 91.95 C \\\\nATOM 608 O VAL A 77 -2.366 8.565 23.031 1.00 91.95 O \\\\nATOM 609 CG1 VAL A 77 -5.582 8.478 24.229 1.00 91.95 C \\\\nATOM 610 CG2 VAL A 77 -6.518 10.015 22.520 1.00 91.95 C \\\\nATOM 611 N SER A 78 -2.256 9.910 24.831 1.00 89.64 N \\\\nATOM 612 CA SER A 78 -0.940 9.453 25.304 1.00 89.64 C \\\\nATOM 613 C SER A 78 0.139 9.719 24.234 1.00 89.64 C \\\\nATOM 614 CB SER A 78 -1.034 7.999 25.813 1.00 89.64 C \\\\nATOM 615 O SER A 78 0.383 10.877 23.894 1.00 89.64 O \\\\nATOM 616 OG SER A 78 -0.107 7.700 26.853 1.00 89.64 O \\\\nATOM 617 N HIS A 79 0.750 8.669 23.679 1.00 87.62 N \\\\nATOM 618 CA HIS A 79 1.822 8.748 22.677 1.00 87.62 C \\\\nATOM 619 C HIS A 79 1.325 8.524 21.236 1.00 87.62 C \\\\nATOM 620 CB HIS A 79 2.944 7.764 23.061 1.00 87.62 C \\\\nATOM 621 O HIS A 79 2.130 8.502 20.315 1.00 87.62 O \\\\nATOM 622 CG HIS A 79 3.317 7.846 24.520 1.00 87.62 C \\\\nATOM 623 CD2 HIS A 79 2.824 7.047 25.515 1.00 87.62 C \\\\nATOM 624 ND1 HIS A 79 4.077 8.821 25.124 1.00 87.62 N \\\\nATOM 625 CE1 HIS A 79 4.026 8.622 26.453 1.00 87.62 C \\\\nATOM 626 NE2 HIS A 79 3.222 7.582 26.741 1.00 87.62 N \\\\nATOM 627 N ARG A 80 0.011 8.342 21.023 1.00 89.06 N \\\\nATOM 628 CA ARG A 80 -0.589 8.120 19.695 1.00 89.06 C \\\\nATOM 629 C ARG A 80 -1.371 9.360 19.252 1.00 89.06 C \\\\nATOM 630 CB ARG A 80 -1.469 6.850 19.695 1.00 89.06 C \\\\nATOM 631 O ARG A 80 -2.094 9.946 20.059 1.00 89.06 O \\\\nATOM 632 CG ARG A 80 -0.694 5.556 20.025 1.00 89.06 C \\\\nATOM 633 CD ARG A 80 -1.591 4.306 19.924 1.00 89.06 C \\\\nATOM 634 NE ARG A 80 -0.844 3.050 20.173 1.00 89.06 N \\\\nATOM 635 NH1 ARG A 80 -2.641 1.599 20.215 1.00 89.06 N \\\\nATOM 636 NH2 ARG A 80 -0.578 0.789 20.395 1.00 89.06 N \\\\nATOM 637 CZ ARG A 80 -1.357 1.827 20.262 1.00 89.06 C \\\\nATOM 638 N LYS A 81 -1.257 9.740 17.976 1.00 91.08 N \\\\nATOM 639 CA LYS A 81 -2.114 10.740 17.313 1.00 91.08 C \\\\nATOM 640 C LYS A 81 -3.033 10.033 16.320 1.00 91.08 C \\\\nATOM 641 CB LYS A 81 -1.278 11.818 16.596 1.00 91.08 C \\\\nATOM 642 O LYS A 81 -2.574 9.153 15.603 1.00 91.08 O \\\\nATOM 643 CG LYS A 81 -0.553 12.772 17.558 1.00 91.08 C \\\\nATOM 644 CD LYS A 81 0.071 13.948 16.788 1.00 91.08 C \\\\nATOM 645 CE LYS A 81 0.707 14.966 17.745 1.00 91.08 C \\\\nATOM 646 NZ LYS A 81 1.119 16.202 17.030 1.00 91.08 N \\\\nATOM 647 N GLY A 82 -4.296 10.436 16.252 1.00 92.21 N \\\\nATOM 648 CA GLY A 82 -5.266 9.886 15.305 1.00 92.21 C \\\\nATOM 649 C GLY A 82 -6.428 10.841 15.063 1.00 92.21 C \\\\nATOM 650 O GLY A 82 -6.586 11.836 15.770 1.00 92.21 O \\\\nATOM 651 N LEU A 83 -7.242 10.562 14.049 1.00 94.68 N \\\\nATOM 652 CA LEU A 83 -8.426 11.370 13.766 1.00 94.68 C \\\\nATOM 653 C LEU A 83 -9.513 11.089 14.819 1.00 94.68 C \\\\nATOM 654 CB LEU A 83 -8.899 11.097 12.332 1.00 94.68 C \\\\nATOM 655 O LEU A 83 -9.783 9.923 15.107 1.00 94.68 O \\\\nATOM 656 CG LEU A 83 -7.914 11.591 11.254 1.00 94.68 C \\\\nATOM 657 CD1 LEU A 83 -8.412 11.182 9.874 1.00 94.68 C \\\\nATOM 658 CD2 LEU A 83 -7.753 13.111 11.288 1.00 94.68 C \\\\nATOM 659 N PRO A 84 -10.135 12.117 15.424 1.00 96.13 N \\\\nATOM 660 CA PRO A 84 -10.963 11.926 16.613 1.00 96.13 C \\\\nATOM 661 C PRO A 84 -12.207 11.073 16.345 1.00 96.13 C \\\\nATOM 662 CB PRO A 84 -11.291 13.335 17.107 1.00 96.13 C \\\\nATOM 663 O PRO A 84 -12.475 10.141 17.096 1.00 96.13 O \\\\nATOM 664 CG PRO A 84 -11.097 14.233 15.887 1.00 96.13 C \\\\nATOM 665 CD PRO A 84 -9.985 13.531 15.117 1.00 96.13 C \\\\nATOM 666 N HIS A 85 -12.917 11.321 15.245 1.00 96.28 N \\\\nATOM 667 CA HIS A 85 -14.066 10.508 14.841 1.00 96.28 C \\\\nATOM 668 C HIS A 85 -13.681 9.035 14.599 1.00 96.28 C \\\\nATOM 669 CB HIS A 85 -14.733 11.152 13.620 1.00 96.28 C \\\\nATOM 670 O HIS A 85 -14.369 8.151 15.099 1.00 96.28 O \\\\nATOM 671 CG HIS A 85 -13.853 11.227 12.398 1.00 96.28 C \\\\nATOM 672 CD2 HIS A 85 -13.950 10.425 11.294 1.00 96.28 C \\\\nATOM 673 ND1 HIS A 85 -12.801 12.094 12.184 1.00 96.28 N \\\\nATOM 674 CE1 HIS A 85 -12.266 11.799 10.989 1.00 96.28 C \\\\nATOM 675 NE2 HIS A 85 -12.924 10.787 10.421 1.00 96.28 N \\\\nATOM 676 N VAL A 86 -12.538 8.761 13.950 1.00 95.91 N \\\\nATOM 677 CA VAL A 86 -12.007 7.394 13.763 1.00 95.91 C \\\\nATOM 678 C VAL A 86 -11.714 6.721 15.103 1.00 95.91 C \\\\nATOM 679 CB VAL A 86 -10.731 7.378 12.895 1.00 95.91 C \\\\nATOM 680 O VAL A 86 -12.126 5.586 15.305 1.00 95.91 O \\\\nATOM 681 CG1 VAL A 86 -10.186 5.964 12.647 1.00 95.91 C \\\\nATOM 682 CG2 VAL A 86 -10.992 7.999 11.526 1.00 95.91 C \\\\nATOM 683 N ILE A 87 -11.056 7.416 16.041 1.00 95.75 N \\\\nATOM 684 CA ILE A 87 -10.737 6.877 17.378 1.00 95.75 C \\\\nATOM 685 C ILE A 87 -12.005 6.382 18.085 1.00 95.75 C \\\\nATOM 686 CB ILE A 87 -9.989 7.938 18.229 1.00 95.75 C \\\\nATOM 687 O ILE A 87 -12.017 5.278 18.627 1.00 95.75 O \\\\nATOM 688 CG1 ILE A 87 -8.549 8.131 17.697 1.00 95.75 C \\\\nATOM 689 CG2 ILE A 87 -9.975 7.568 19.729 1.00 95.75 C \\\\nATOM 690 CD1 ILE A 87 -7.835 9.374 18.251 1.00 95.75 C \\\\nATOM 691 N TYR A 88 -13.070 7.184 18.078 1.00 97.01 N \\\\nATOM 692 CA TYR A 88 -14.292 6.876 18.820 1.00 97.01 C \\\\nATOM 693 C TYR A 88 -15.236 5.921 18.067 1.00 97.01 C \\\\nATOM 694 CB TYR A 88 -14.923 8.197 19.280 1.00 97.01 C \\\\nATOM 695 O TYR A 88 -15.862 5.073 18.706 1.00 97.01 O \\\\nATOM 696 CG TYR A 88 -14.039 8.958 20.269 1.00 97.01 C \\\\nATOM 697 CD1 TYR A 88 -13.650 8.363 21.488 1.00 97.01 C \\\\nATOM 698 CD2 TYR A 88 -13.542 10.235 19.946 1.00 97.01 C \\\\nATOM 699 CE1 TYR A 88 -12.758 9.025 22.356 1.00 97.01 C \\\\nATOM 700 CE2 TYR A 88 -12.657 10.909 20.809 1.00 97.01 C \\\\nATOM 701 OH TYR A 88 -11.359 10.917 22.833 1.00 97.01 O \\\\nATOM 702 CZ TYR A 88 -12.249 10.297 22.010 1.00 97.01 C \\\\nATOM 703 N CYS A 89 -15.259 5.944 16.728 1.00 97.14 N \\\\nATOM 704 CA CYS A 89 -15.911 4.899 15.927 1.00 97.14 C \\\\nATOM 705 C CYS A 89 -15.223 3.538 16.102 1.00 97.14 C \\\\nATOM 706 CB CYS A 89 -15.940 5.300 14.446 1.00 97.14 C \\\\nATOM 707 O CYS A 89 -15.909 2.531 16.282 1.00 97.14 O \\\\nATOM 708 SG CYS A 89 -17.012 6.741 14.207 1.00 97.14 S \\\\nATOM 709 N ARG A 90 -13.881 3.502 16.131 1.00 94.96 N \\\\nATOM 710 CA ARG A 90 -13.118 2.270 16.374 1.00 94.96 C \\\\nATOM 711 C ARG A 90 -13.416 1.683 17.753 1.00 94.96 C \\\\nATOM 712 CB ARG A 90 -11.610 2.504 16.148 1.00 94.96 C \\\\nATOM 713 O ARG A 90 -13.631 0.485 17.889 1.00 94.96 O \\\\nATOM 714 CG ARG A 90 -10.822 1.179 16.147 1.00 94.96 C \\\\nATOM 715 CD ARG A 90 -9.299 1.349 16.072 1.00 94.96 C \\\\nATOM 716 NE ARG A 90 -8.859 1.913 14.783 1.00 94.96 N \\\\nATOM 717 NH1 ARG A 90 -6.593 1.849 15.128 1.00 94.96 N \\\\nATOM 718 NH2 ARG A 90 -7.394 2.582 13.182 1.00 94.96 N \\\\nATOM 719 CZ ARG A 90 -7.620 2.119 14.376 1.00 94.96 C \\\\nATOM 720 N LEU A 91 -13.475 2.541 18.774 1.00 95.35 N \\\\nATOM 721 CA LEU A 91 -13.684 2.125 20.161 1.00 95.35 C \\\\nATOM 722 C LEU A 91 -15.085 1.529 20.399 1.00 95.35 C \\\\nATOM 723 CB LEU A 91 -13.349 3.325 21.071 1.00 95.35 C \\\\nATOM 724 O LEU A 91 -15.193 0.505 21.071 1.00 95.35 O \\\\nATOM 725 CG LEU A 91 -13.069 2.959 22.541 1.00 95.35 C \\\\nATOM 726 CD1 LEU A 91 -12.143 4.000 23.179 1.00 95.35 C \\\\nATOM 727 CD2 LEU A 91 -14.329 2.914 23.405 1.00 95.35 C \\\\nATOM 728 N TRP A 92 -16.144 2.141 19.854 1.00 96.60 N \\\\nATOM 729 CA TRP A 92 -17.537 1.766 20.157 1.00 96.60 C \\\\nATOM 730 C TRP A 92 -18.284 0.994 19.062 1.00 96.60 C \\\\nATOM 731 CB TRP A 92 -18.313 3.021 20.582 1.00 96.60 C \\\\nATOM 732 O TRP A 92 -19.358 0.464 19.347 1.00 96.60 O \\\\nATOM 733 CG TRP A 92 -17.957 3.535 21.942 1.00 96.60 C \\\\nATOM 734 CD1 TRP A 92 -18.066 2.819 23.082 1.00 96.60 C \\\\nATOM 735 CD2 TRP A 92 -17.462 4.850 22.345 1.00 96.60 C \\\\nATOM 736 CE2 TRP A 92 -17.256 4.832 23.759 1.00 96.60 C \\\\nATOM 737 CE3 TRP A 92 -17.178 6.059 21.672 1.00 96.60 C \\\\nATOM 738 NE1 TRP A 92 -17.647 3.572 24.156 1.00 96.60 N \\\\nATOM 739 CH2 TRP A 92 -16.458 7.112 23.753 1.00 96.60 C \\\\nATOM 740 CZ2 TRP A 92 -16.732 5.930 24.453 1.00 96.60 C \\\\nATOM 741 CZ3 TRP A 92 -16.710 7.188 22.373 1.00 96.60 C \\\\nATOM 742 N ARG A 93 -17.759 0.902 17.831 1.00 95.15 N \\\\nATOM 743 CA ARG A 93 -18.455 0.233 16.712 1.00 95.15 C \\\\nATOM 744 C ARG A 93 -17.601 -0.788 15.968 1.00 95.15 C \\\\nATOM 745 CB ARG A 93 -19.070 1.267 15.755 1.00 95.15 C \\\\nATOM 746 O ARG A 93 -17.990 -1.951 15.932 1.00 95.15 O \\\\nATOM 747 CG ARG A 93 -20.137 2.119 16.462 1.00 95.15 C \\\\nATOM 748 CD ARG A 93 -20.863 3.041 15.485 1.00 95.15 C \\\\nATOM 749 NE ARG A 93 -21.743 2.298 14.563 1.00 95.15 N \\\\nATOM 750 NH1 ARG A 93 -22.348 4.110 13.332 1.00 95.15 N \\\\nATOM 751 NH2 ARG A 93 -23.186 2.127 12.794 1.00 95.15 N \\\\nATOM 752 CZ ARG A 93 -22.420 2.840 13.570 1.00 95.15 C \\\\nATOM 753 N TRP A 94 -16.461 -0.377 15.415 1.00 94.17 N \\\\nATOM 754 CA TRP A 94 -15.676 -1.193 14.474 1.00 94.17 C \\\\nATOM 755 C TRP A 94 -14.194 -1.247 14.882 1.00 94.17 C \\\\nATOM 756 CB TRP A 94 -15.855 -0.623 13.061 1.00 94.17 C \\\\nATOM 757 O TRP A 94 -13.423 -0.380 14.469 1.00 94.17 O \\\\nATOM 758 CG TRP A 94 -17.264 -0.527 12.567 1.00 94.17 C \\\\nATOM 759 CD1 TRP A 94 -18.073 -1.569 12.277 1.00 94.17 C \\\\nATOM 760 CD2 TRP A 94 -18.039 0.675 12.283 1.00 94.17 C \\\\nATOM 761 CE2 TRP A 94 -19.324 0.281 11.803 1.00 94.17 C \\\\nATOM 762 CE3 TRP A 94 -17.778 2.060 12.376 1.00 94.17 C \\\\nATOM 763 NE1 TRP A 94 -19.289 -1.098 11.818 1.00 94.17 N \\\\nATOM 764 CH2 TRP A 94 -19.992 2.588 11.501 1.00 94.17 C \\\\nATOM 765 CZ2 TRP A 94 -20.291 1.216 11.407 1.00 94.17 C \\\\nATOM 766 CZ3 TRP A 94 -18.748 3.008 11.999 1.00 94.17 C \\\\nATOM 767 N PRO A 95 -13.767 -2.218 15.713 1.00 91.85 N \\\\nATOM 768 CA PRO A 95 -12.377 -2.334 16.180 1.00 91.85 C \\\\nATOM 769 C PRO A 95 -11.349 -2.409 15.044 1.00 91.85 C \\\\nATOM 770 CB PRO A 95 -12.335 -3.624 17.007 1.00 91.85 C \\\\nATOM 771 O PRO A 95 -10.232 -1.917 15.177 1.00 91.85 O \\\\nATOM 772 CG PRO A 95 -13.776 -3.784 17.471 1.00 91.85 C \\\\nATOM 773 CD PRO A 95 -14.589 -3.261 16.296 1.00 91.85 C \\\\nATOM 774 N ASP A 96 -11.778 -2.981 13.924 1.00 88.11 N \\\\nATOM 775 CA ASP A 96 -11.075 -3.212 12.665 1.00 88.11 C \\\\nATOM 776 C ASP A 96 -11.137 -2.021 11.684 1.00 88.11 C \\\\nATOM 777 CB ASP A 96 -11.697 -4.475 12.048 1.00 88.11 C \\\\nATOM 778 O ASP A 96 -10.795 -2.157 10.514 1.00 88.11 O \\\\nATOM 779 CG ASP A 96 -13.152 -4.244 11.620 1.00 88.11 C \\\\nATOM 780 OD1 ASP A 96 -13.968 -3.756 12.443 1.00 88.11 O \\\\nATOM 781 OD2 ASP A 96 -13.460 -4.509 10.440 1.00 88.11 O \\\\nATOM 782 N LEU A 97 -11.589 -0.845 12.128 1.00 90.03 N \\\\nATOM 783 CA LEU A 97 -11.603 0.378 11.321 1.00 90.03 C \\\\nATOM 784 C LEU A 97 -10.190 0.968 11.204 1.00 90.03 C \\\\nATOM 785 CB LEU A 97 -12.558 1.369 12.005 1.00 90.03 C \\\\nATOM 786 O LEU A 97 -9.690 1.539 12.177 1.00 90.03 O \\\\nATOM 787 CG LEU A 97 -12.699 2.703 11.262 1.00 90.03 C \\\\nATOM 788 CD1 LEU A 97 -13.601 2.541 10.045 1.00 90.03 C \\\\nATOM 789 CD2 LEU A 97 -13.313 3.751 12.188 1.00 90.03 C \\\\nATOM 790 N HIS A 98 -9.561 0.935 10.034 1.00 83.53 N \\\\nATOM 791 CA HIS A 98 -8.185 1.398 9.822 1.00 83.53 C \\\\nATOM 792 C HIS A 98 -8.109 2.885 9.443 1.00 83.53 C \\\\nATOM 793 CB HIS A 98 -7.491 0.500 8.787 1.00 83.53 C \\\\nATOM 794 O HIS A 98 -7.307 3.624 10.024 1.00 83.53 O \\\\nATOM 795 CG HIS A 98 -7.350 -0.918 9.279 1.00 83.53 C \\\\nATOM 796 CD2 HIS A 98 -6.292 -1.441 9.975 1.00 83.53 C \\\\nATOM 797 ND1 HIS A 98 -8.318 -1.894 9.231 1.00 83.53 N \\\\nATOM 798 CE1 HIS A 98 -7.867 -2.964 9.902 1.00 83.53 C \\\\nATOM 799 NE2 HIS A 98 -6.648 -2.722 10.403 1.00 83.53 N \\\\nATOM 800 N SER A 99 -8.966 3.349 8.528 1.00 85.84 N \\\\nATOM 801 CA SER A 99 -8.930 4.700 7.946 1.00 85.84 C \\\\nATOM 802 C SER A 99 -10.231 5.484 8.140 1.00 85.84 C \\\\nATOM 803 CB SER A 99 -8.601 4.601 6.452 1.00 85.84 C \\\\nATOM 804 O SER A 99 -11.318 4.925 8.226 1.00 85.84 O \\\\nATOM 805 OG SER A 99 -8.411 5.893 5.882 1.00 85.84 O \\\\nATOM 806 N HIS A 100 -10.141 6.818 8.123 1.00 89.28 N \\\\nATOM 807 CA HIS A 100 -11.322 7.683 7.992 1.00 89.28 C \\\\nATOM 808 C HIS A 100 -12.066 7.522 6.664 1.00 89.28 C \\\\nATOM 809 CB HIS A 100 -10.934 9.152 8.163 1.00 89.28 C \\\\nATOM 810 O HIS A 100 -13.252 7.814 6.608 1.00 89.28 O \\\\nATOM 811 CG HIS A 100 -10.106 9.767 7.057 1.00 89.28 C \\\\nATOM 812 CD2 HIS A 100 -10.271 11.039 6.582 1.00 89.28 C \\\\nATOM 813 ND1 HIS A 100 -9.054 9.208 6.355 1.00 89.28 N \\\\nATOM 814 CE1 HIS A 100 -8.602 10.136 5.494 1.00 89.28 C \\\\nATOM 815 NE2 HIS A 100 -9.290 11.280 5.620 1.00 89.28 N \\\\nATOM 816 N HIS A 101 -11.389 7.043 5.617 1.00 87.61 N \\\\nATOM 817 CA HIS A 101 -11.995 6.815 4.305 1.00 87.61 C \\\\nATOM 818 C HIS A 101 -13.023 5.667 4.339 1.00 87.61 C \\\\nATOM 819 CB HIS A 101 -10.877 6.550 3.288 1.00 87.61 C \\\\nATOM 820 O HIS A 101 -13.914 5.620 3.502 1.00 87.61 O \\\\nATOM 821 CG HIS A 101 -9.903 7.679 3.043 1.00 87.61 C \\\\nATOM 822 CD2 HIS A 101 -8.576 7.525 2.753 1.00 87.61 C \\\\nATOM 823 ND1 HIS A 101 -10.253 9.008 2.824 1.00 87.61 N \\\\nATOM 824 CE1 HIS A 101 -9.148 9.614 2.366 1.00 87.61 C \\\\nATOM 825 NE2 HIS A 101 -8.114 8.755 2.330 1.00 87.61 N \\\\nATOM 826 N GLU A 102 -12.947 4.778 5.340 1.00 91.34 N \\\\nATOM 827 CA GLU A 102 -13.962 3.748 5.612 1.00 91.34 C \\\\nATOM 828 C GLU A 102 -15.215 4.320 6.298 1.00 91.34 C \\\\nATOM 829 CB GLU A 102 -13.376 2.657 6.521 1.00 91.34 C \\\\nATOM 830 O GLU A 102 -16.148 3.567 6.567 1.00 91.34 O \\\\nATOM 831 CG GLU A 102 -12.282 1.772 5.924 1.00 91.34 C \\\\nATOM 832 CD GLU A 102 -11.709 0.897 7.044 1.00 91.34 C \\\\nATOM 833 OE1 GLU A 102 -10.610 1.257 7.528 1.00 91.34 O \\\\nATOM 834 OE2 GLU A 102 -12.403 -0.044 7.507 1.00 91.34 O \\\\nATOM 835 N LEU A 103 -15.260 5.621 6.617 1.00 94.44 N \\\\nATOM 836 CA LEU A 103 -16.401 6.278 7.252 1.00 94.44 C \\\\nATOM 837 C LEU A 103 -17.027 7.334 6.336 1.00 94.44 C \\\\nATOM 838 CB LEU A 103 -15.993 6.932 8.583 1.00 94.44 C \\\\nATOM 839 O LEU A 103 -16.368 8.273 5.892 1.00 94.44 O \\\\nATOM 840 CG LEU A 103 -15.497 5.984 9.685 1.00 94.44 C \\\\nATOM 841 CD1 LEU A 103 -15.192 6.821 10.931 1.00 94.44 C \\\\nATOM 842 CD2 LEU A 103 -16.527 4.918 10.060 1.00 94.44 C \\\\nATOM 843 N ARG A 104 -18.346 7.257 6.169 1.00 93.98 N \\\\nATOM 844 CA ARG A 104 -19.178 8.341 5.637 1.00 93.98 C \\\\nATOM 845 C ARG A 104 -19.914 9.007 6.796 1.00 93.98 C \\\\nATOM 846 CB ARG A 104 -20.119 7.758 4.574 1.00 93.98 C \\\\nATOM 847 O ARG A 104 -20.406 8.315 7.679 1.00 93.98 O \\\\nATOM 848 CG ARG A 104 -20.871 8.846 3.792 1.00 93.98 C \\\\nATOM 849 CD ARG A 104 -21.746 8.249 2.682 1.00 93.98 C \\\\nATOM 850 NE ARG A 104 -20.942 7.590 1.630 1.00 93.98 N \\\\nATOM 851 NH1 ARG A 104 -22.690 6.672 0.453 1.00 93.98 N \\\\nATOM 852 NH2 ARG A 104 -20.597 6.298 -0.217 1.00 93.98 N \\\\nATOM 853 CZ ARG A 104 -21.412 6.861 0.631 1.00 93.98 C \\\\nATOM 854 N ALA A 105 -19.987 10.334 6.832 1.00 95.58 N \\\\nATOM 855 CA ALA A 105 -20.825 11.016 7.817 1.00 95.58 C \\\\nATOM 856 C ALA A 105 -22.312 10.886 7.449 1.00 95.58 C \\\\nATOM 857 CB ALA A 105 -20.386 12.473 7.934 1.00 95.58 C \\\\nATOM 858 O ALA A 105 -22.654 10.912 6.269 1.00 95.58 O \\\\nATOM 859 N MET A 106 -23.180 10.771 8.454 1.00 94.73 N \\\\nATOM 860 CA MET A 106 -24.633 10.840 8.263 1.00 94.73 C \\\\nATOM 861 C MET A 106 -25.040 12.262 7.857 1.00 94.73 C \\\\nATOM 862 CB MET A 106 -25.367 10.441 9.556 1.00 94.73 C \\\\nATOM 863 O MET A 106 -24.473 13.227 8.368 1.00 94.73 O \\\\nATOM 864 CG MET A 106 -25.076 9.008 10.024 1.00 94.73 C \\\\nATOM 865 SD MET A 106 -25.501 7.677 8.871 1.00 94.73 S \\\\nATOM 866 CE MET A 106 -27.310 7.807 8.826 1.00 94.73 C \\\\nATOM 867 N GLU A 107 -26.060 12.403 7.010 1.00 93.15 N \\\\nATOM 868 CA GLU A 107 -26.558 13.710 6.533 1.00 93.15 C \\\\nATOM 869 C GLU A 107 -27.026 14.628 7.677 1.00 93.15 C \\\\nATOM 870 CB GLU A 107 -27.710 13.476 5.544 1.00 93.15 C \\\\nATOM 871 O GLU A 107 -26.850 15.841 7.622 1.00 93.15 O \\\\nATOM 872 CG GLU A 107 -27.247 12.693 4.303 1.00 93.15 C \\\\nATOM 873 CD GLU A 107 -28.367 12.438 3.284 1.00 93.15 C \\\\nATOM 874 OE1 GLU A 107 -28.010 11.970 2.181 1.00 93.15 O \\\\nATOM 875 OE2 GLU A 107 -29.546 12.670 3.630 1.00 93.15 O \\\\nATOM 876 N LEU A 108 -27.527 14.035 8.765 1.00 93.69 N \\\\nATOM 877 CA LEU A 108 -27.938 14.715 10.001 1.00 93.69 C \\\\nATOM 878 C LEU A 108 -26.760 15.276 10.835 1.00 93.69 C \\\\nATOM 879 CB LEU A 108 -28.760 13.713 10.841 1.00 93.69 C \\\\nATOM 880 O LEU A 108 -26.981 15.903 11.870 1.00 93.69 O \\\\nATOM 881 CG LEU A 108 -30.059 13.205 10.182 1.00 93.69 C \\\\nATOM 882 CD1 LEU A 108 -30.610 12.023 10.982 1.00 93.69 C \\\\nATOM 883 CD2 LEU A 108 -31.133 14.292 10.122 1.00 93.69 C \\\\nATOM 884 N CYS A 109 -25.503 15.021 10.455 1.00 96.21 N \\\\nATOM 885 CA CYS A 109 -24.330 15.402 11.242 1.00 96.21 C \\\\nATOM 886 C CYS A 109 -23.824 16.809 10.888 1.00 96.21 C \\\\nATOM 887 CB CYS A 109 -23.247 14.332 11.086 1.00 96.21 C \\\\nATOM 888 O CYS A 109 -22.939 16.987 10.050 1.00 96.21 O \\\\nATOM 889 SG CYS A 109 -21.880 14.671 12.240 1.00 96.21 S \\\\nATOM 890 N GLU A 110 -24.309 17.816 11.614 1.00 96.46 N \\\\nATOM 891 CA GLU A 110 -23.943 19.229 11.425 1.00 96.46 C \\\\nATOM 892 C GLU A 110 -22.450 19.545 11.646 1.00 96.46 C \\\\nATOM 893 CB GLU A 110 -24.740 20.085 12.415 1.00 96.46 C \\\\nATOM 894 O GLU A 110 -21.980 20.613 11.249 1.00 96.46 O \\\\nATOM 895 CG GLU A 110 -26.263 19.981 12.271 1.00 96.46 C \\\\nATOM 896 CD GLU A 110 -26.979 20.882 13.289 1.00 96.46 C \\\\nATOM 897 OE1 GLU A 110 -28.101 21.328 12.975 1.00 96.46 O \\\\nATOM 898 OE2 GLU A 110 -26.391 21.128 14.371 1.00 96.46 O \\\\nATOM 899 N PHE A 111 -21.695 18.655 12.297 1.00 97.34 N \\\\nATOM 900 CA PHE A 111 -20.281 18.845 12.653 1.00 97.34 C \\\\nATOM 901 C PHE A 111 -19.386 17.721 12.109 1.00 97.34 C \\\\nATOM 902 CB PHE A 111 -20.146 19.067 14.169 1.00 97.34 C \\\\nATOM 903 O PHE A 111 -18.363 17.375 12.709 1.00 97.34 O \\\\nATOM 904 CG PHE A 111 -20.828 20.321 14.674 1.00 97.34 C \\\\nATOM 905 CD1 PHE A 111 -20.106 21.524 14.784 1.00 97.34 C \\\\nATOM 906 CD2 PHE A 111 -22.187 20.286 15.038 1.00 97.34 C \\\\nATOM 907 CE1 PHE A 111 -20.739 22.681 15.274 1.00 97.34 C \\\\nATOM 908 CE2 PHE A 111 -22.828 21.447 15.497 1.00 97.34 C \\\\nATOM 909 CZ PHE A 111 -22.101 22.642 15.627 1.00 97.34 C \\\\nATOM 910 N ALA A 112 -19.768 17.115 10.985 1.00 95.98 N \\\\nATOM 911 CA ALA A 112 -19.009 16.040 10.359 1.00 95.98 C \\\\nATOM 912 C ALA A 112 -17.552 16.444 10.052 1.00 95.98 C \\\\nATOM 913 CB ALA A 112 -19.760 15.597 9.106 1.00 95.98 C \\\\nATOM 914 O ALA A 112 -17.249 17.588 9.699 1.00 95.98 O \\\\nATOM 915 N PHE A 113 -16.612 15.499 10.184 1.00 93.94 N \\\\nATOM 916 CA PHE A 113 -15.178 15.800 10.078 1.00 93.94 C \\\\nATOM 917 C PHE A 113 -14.775 16.480 8.756 1.00 93.94 C \\\\nATOM 918 CB PHE A 113 -14.367 14.516 10.278 1.00 93.94 C \\\\nATOM 919 O PHE A 113 -13.932 17.385 8.777 1.00 93.94 O \\\\nATOM 920 CG PHE A 113 -12.874 14.717 10.076 1.00 93.94 C \\\\nATOM 921 CD1 PHE A 113 -12.257 14.293 8.882 1.00 93.94 C \\\\nATOM 922 CD2 PHE A 113 -12.103 15.355 11.066 1.00 93.94 C \\\\nATOM 923 CE1 PHE A 113 -10.881 14.503 8.686 1.00 93.94 C \\\\nATOM 924 CE2 PHE A 113 -10.724 15.550 10.880 1.00 93.94 C \\\\nATOM 925 CZ PHE A 113 -10.117 15.137 9.681 1.00 93.94 C \\\\nATOM 926 N ASN A 114 -15.397 16.080 7.643 1.00 91.30 N \\\\nATOM 927 CA ASN A 114 -15.186 16.613 6.295 1.00 91.30 C \\\\nATOM 928 C ASN A 114 -15.691 18.056 6.101 1.00 91.30 C \\\\nATOM 929 CB ASN A 114 -15.829 15.658 5.264 1.00 91.30 C \\\\nATOM 930 O ASN A 114 -15.181 18.738 5.219 1.00 91.30 O \\\\nATOM 931 CG ASN A 114 -17.340 15.517 5.407 1.00 91.30 C \\\\nATOM 932 ND2 ASN A 114 -18.054 15.240 4.344 1.00 91.30 N \\\\nATOM 933 OD1 ASN A 114 -17.887 15.635 6.490 1.00 91.30 O \\\\nATOM 934 N MET A 115 -16.607 18.556 6.941 1.00 93.28 N \\\\nATOM 935 CA MET A 115 -17.109 19.941 6.870 1.00 93.28 C \\\\nATOM 936 C MET A 115 -16.089 20.993 7.338 1.00 93.28 C \\\\nATOM 937 CB MET A 115 -18.397 20.097 7.694 1.00 93.28 C \\\\nATOM 938 O MET A 115 -16.359 22.185 7.245 1.00 93.28 O \\\\nATOM 939 CG MET A 115 -19.531 19.178 7.245 1.00 93.28 C \\\\nATOM 940 SD MET A 115 -21.011 19.386 8.269 1.00 93.28 S \\\\nATOM 941 CE MET A 115 -22.025 20.428 7.188 1.00 93.28 C \\\\nATOM 942 N LYS A 116 -14.933 20.574 7.879 1.00 91.49 N \\\\nATOM 943 CA LYS A 116 -13.805 21.437 8.299 1.00 91.49 C \\\\nATOM 944 C LYS A 116 -14.143 22.582 9.284 1.00 91.49 C \\\\nATOM 945 CB LYS A 116 -13.025 21.940 7.064 1.00 91.49 C \\\\nATOM 946 O LYS A 116 -13.315 23.465 9.464 1.00 91.49 O \\\\nATOM 947 CG LYS A 116 -12.402 20.814 6.222 1.00 91.49 C \\\\nATOM 948 CD LYS A 116 -11.661 21.398 5.012 1.00 91.49 C \\\\nATOM 949 CE LYS A 116 -11.126 20.283 4.104 1.00 91.49 C \\\\nATOM 950 NZ LYS A 116 -10.485 20.836 2.882 1.00 91.49 N \\\\nATOM 951 N LYS A 117 -15.291 22.530 9.975 1.00 94.76 N \\\\nATOM 952 CA LYS A 117 -15.671 23.462 11.058 1.00 94.76 C \\\\nATOM 953 C LYS A 117 -14.675 23.438 12.231 1.00 94.76 C \\\\nATOM 954 CB LYS A 117 -17.094 23.133 11.562 1.00 94.76 C \\\\nATOM 955 O LYS A 117 -13.972 22.443 12.419 1.00 94.76 O \\\\nATOM 956 CG LYS A 117 -18.187 23.326 10.495 1.00 94.76 C \\\\nATOM 957 CD LYS A 117 -19.589 23.130 11.097 1.00 94.76 C \\\\nATOM 958 CE LYS A 117 -20.685 23.404 10.057 1.00 94.76 C \\\\nATOM 959 NZ LYS A 117 -22.042 23.260 10.645 1.00 94.76 N \\\\nATOM 960 N ASP A 118 -14.688 24.484 13.060 1.00 95.42 N \\\\nATOM 961 CA ASP A 118 -13.849 24.625 14.270 1.00 95.42 C \\\\nATOM 962 C ASP A 118 -14.050 23.504 15.300 1.00 95.42 C \\\\nATOM 963 CB ASP A 118 -14.163 25.963 14.953 1.00 95.42 C \\\\nATOM 964 O ASP A 118 -13.168 23.209 16.108 1.00 95.42 O \\\\nATOM 965 CG ASP A 118 -13.874 27.158 14.050 1.00 95.42 C \\\\nATOM 966 OD1 ASP A 118 -12.850 27.096 13.335 1.00 95.42 O \\\\nATOM 967 OD2 ASP A 118 -14.713 28.080 14.050 1.00 95.42 O \\\\nATOM 968 N GLU A 119 -15.197 22.831 15.240 1.00 96.27 N \\\\nATOM 969 CA GLU A 119 -15.482 21.617 15.990 1.00 96.27 C \\\\nATOM 970 C GLU A 119 -15.620 20.390 15.078 1.00 96.27 C \\\\nATOM 971 CB GLU A 119 -16.725 21.802 16.862 1.00 96.27 C \\\\nATOM 972 O GLU A 119 -15.860 20.478 13.870 1.00 96.27 O \\\\nATOM 973 CG GLU A 119 -16.575 22.893 17.932 1.00 96.27 C \\\\nATOM 974 CD GLU A 119 -17.483 22.585 19.128 1.00 96.27 C \\\\nATOM 975 OE1 GLU A 119 -16.925 22.384 20.230 1.00 96.27 O \\\\nATOM 976 OE2 GLU A 119 -18.703 22.390 18.922 1.00 96.27 O \\\\nATOM 977 N VAL A 120 -15.467 19.208 15.673 1.00 96.95 N \\\\nATOM 978 CA VAL A 120 -15.663 17.914 15.015 1.00 96.95 C \\\\nATOM 979 C VAL A 120 -16.561 17.015 15.856 1.00 96.95 C \\\\nATOM 980 CB VAL A 120 -14.313 17.253 14.669 1.00 96.95 C \\\\nATOM 981 O VAL A 120 -16.314 16.811 17.046 1.00 96.95 O \\\\nATOM 982 CG1 VAL A 120 -13.321 17.164 15.838 1.00 96.95 C \\\\nATOM 983 CG2 VAL A 120 -14.496 15.836 14.107 1.00 96.95 C \\\\nATOM 984 N CYS A 121 -17.576 16.433 15.216 1.00 97.92 N \\\\nATOM 985 CA CYS A 121 -18.431 15.420 15.813 1.00 97.92 C \\\\nATOM 986 C CYS A 121 -17.659 14.112 16.029 1.00 97.92 C \\\\nATOM 987 CB CYS A 121 -19.679 15.186 14.954 1.00 97.92 C \\\\nATOM 988 O CYS A 121 -17.033 13.574 15.111 1.00 97.92 O \\\\nATOM 989 SG CYS A 121 -20.832 14.159 15.908 1.00 97.92 S \\\\nATOM 990 N VAL A 122 -17.752 13.582 17.243 1.00 97.72 N \\\\nATOM 991 CA VAL A 122 -17.203 12.298 17.686 1.00 97.72 C \\\\nATOM 992 C VAL A 122 -18.285 11.307 18.125 1.00 97.72 C \\\\nATOM 993 CB VAL A 122 -16.141 12.495 18.782 1.00 97.72 C \\\\nATOM 994 O VAL A 122 -17.956 10.257 18.673 1.00 97.72 O \\\\nATOM 995 CG1 VAL A 122 -14.932 13.260 18.234 1.00 97.72 C \\\\nATOM 996 CG2 VAL A 122 -16.642 13.217 20.035 1.00 97.72 C \\\\nATOM 997 N ASN A 123 -19.565 11.613 17.879 1.00 97.71 N \\\\nATOM 998 CA ASN A 123 -20.654 10.650 18.046 1.00 97.71 C \\\\nATOM 999 C ASN A 123 -20.443 9.497 17.044 1.00 97.71 C \\\\nATOM 1000 CB ASN A 123 -22.010 11.357 17.833 1.00 97.71 C \\\\nATOM 1001 O ASN A 123 -20.509 9.739 15.837 1.00 97.71 O \\\\nATOM 1002 CG ASN A 123 -23.206 10.461 18.123 1.00 97.71 C \\\\nATOM 1003 ND2 ASN A 123 -24.356 11.036 18.386 1.00 97.71 N \\\\nATOM 1004 OD1 ASN A 123 -23.101 9.241 18.132 1.00 97.71 O \\\\nATOM 1005 N PRO A 124 -20.192 8.251 17.485 1.00 97.24 N \\\\nATOM 1006 CA PRO A 124 -19.894 7.164 16.560 1.00 97.24 C \\\\nATOM 1007 C PRO A 124 -21.113 6.735 15.729 1.00 97.24 C \\\\nATOM 1008 CB PRO A 124 -19.341 6.042 17.439 1.00 97.24 C \\\\nATOM 1009 O PRO A 124 -20.937 6.063 14.717 1.00 97.24 O \\\\nATOM 1010 CG PRO A 124 -20.066 6.254 18.763 1.00 97.24 C \\\\nATOM 1011 CD PRO A 124 -20.149 7.776 18.862 1.00 97.24 C \\\\nATOM 1012 N TYR A 125 -22.334 7.132 16.107 1.00 97.21 N \\\\nATOM 1013 CA TYR A 125 -23.568 6.894 15.342 1.00 97.21 C \\\\nATOM 1014 C TYR A 125 -23.873 8.001 14.322 1.00 97.21 C \\\\nATOM 1015 CB TYR A 125 -24.731 6.614 16.304 1.00 97.21 C \\\\nATOM 1016 O TYR A 125 -24.833 7.895 13.569 1.00 97.21 O \\\\nATOM 1017 CG TYR A 125 -24.449 5.401 17.166 1.00 97.21 C \\\\nATOM 1018 CD1 TYR A 125 -24.625 4.107 16.637 1.00 97.21 C \\\\nATOM 1019 CD2 TYR A 125 -23.912 5.567 18.455 1.00 97.21 C \\\\nATOM 1020 CE1 TYR A 125 -24.241 2.979 17.387 1.00 97.21 C \\\\nATOM 1021 CE2 TYR A 125 -23.528 4.440 19.204 1.00 97.21 C \\\\nATOM 1022 OH TYR A 125 -23.321 2.060 19.402 1.00 97.21 O \\\\nATOM 1023 CZ TYR A 125 -23.690 3.144 18.673 1.00 97.21 C \\\\nATOM 1024 N HIS A 126 -23.027 9.035 14.238 1.00 97.82 N \\\\nATOM 1025 CA HIS A 126 -23.063 10.054 13.176 1.00 97.82 C \\\\nATOM 1026 C HIS A 126 -22.159 9.726 11.984 1.00 97.82 C \\\\nATOM 1027 CB HIS A 126 -22.751 11.426 13.780 1.00 97.82 C \\\\nATOM 1028 O HIS A 126 -21.988 10.547 11.084 1.00 97.82 O \\\\nATOM 1029 CG HIS A 126 -23.879 12.016 14.583 1.00 97.82 C \\\\nATOM 1030 CD2 HIS A 126 -25.075 11.415 14.857 1.00 97.82 C \\\\nATOM 1031 ND1 HIS A 126 -23.925 13.346 15.007 1.00 97.82 N \\\\nATOM 1032 CE1 HIS A 126 -25.172 13.518 15.476 1.00 97.82 C \\\\nATOM 1033 NE2 HIS A 126 -25.864 12.375 15.425 1.00 97.82 N \\\\nATOM 1034 N TYR A 127 -21.611 8.513 11.960 1.00 97.31 N \\\\nATOM 1035 CA TYR A 127 -20.844 7.963 10.852 1.00 97.31 C \\\\nATOM 1036 C TYR A 127 -21.405 6.582 10.486 1.00 97.31 C \\\\nATOM 1037 CB TYR A 127 -19.353 7.915 11.234 1.00 97.31 C \\\\nATOM 1038 O TYR A 127 -21.826 5.831 11.364 1.00 97.31 O \\\\nATOM 1039 CG TYR A 127 -18.749 9.275 11.566 1.00 97.31 C \\\\nATOM 1040 CD1 TYR A 127 -18.178 10.061 10.546 1.00 97.31 C \\\\nATOM 1041 CD2 TYR A 127 -18.801 9.777 12.883 1.00 97.31 C \\\\nATOM 1042 CE1 TYR A 127 -17.676 11.346 10.836 1.00 97.31 C \\\\nATOM 1043 CE2 TYR A 127 -18.315 11.068 13.176 1.00 97.31 C \\\\nATOM 1044 OH TYR A 127 -17.256 13.099 12.420 1.00 97.31 O \\\\nATOM 1045 CZ TYR A 127 -17.754 11.859 12.148 1.00 97.31 C \\\\nATOM 1046 N GLN A 128 -21.398 6.218 9.210 1.00 94.94 N \\\\nATOM 1047 CA GLN A 128 -21.660 4.866 8.717 1.00 94.94 C \\\\nATOM 1048 C GLN A 128 -20.363 4.307 8.128 1.00 94.94 C \\\\nATOM 1049 CB GLN A 128 -22.818 4.891 7.707 1.00 94.94 C \\\\nATOM 1050 O GLN A 128 -19.571 5.061 7.559 1.00 94.94 O \\\\nATOM 1051 CG GLN A 128 -23.315 3.479 7.337 1.00 94.94 C \\\\nATOM 1052 CD GLN A 128 -24.500 3.481 6.375 1.00 94.94 C \\\\nATOM 1053 NE2 GLN A 128 -24.954 2.326 5.934 1.00 94.94 N \\\\nATOM 1054 OE1 GLN A 128 -25.037 4.517 6.017 1.00 94.94 O \\\\nATOM 1055 N ARG A 129 -20.128 2.999 8.271 1.00 93.24 N \\\\nATOM 1056 CA ARG A 129 -19.017 2.345 7.577 1.00 93.24 C \\\\nATOM 1057 C ARG A 129 -19.354 2.248 6.093 1.00 93.24 C \\\\nATOM 1058 CB ARG A 129 -18.701 0.979 8.201 1.00 93.24 C \\\\nATOM 1059 O ARG A 129 -20.494 1.964 5.745 1.00 93.24 O \\\\nATOM 1060 CG ARG A 129 -17.357 0.430 7.701 1.00 93.24 C \\\\nATOM 1061 CD ARG A 129 -17.001 -0.874 8.416 1.00 93.24 C \\\\nATOM 1062 NE ARG A 129 -15.580 -1.217 8.225 1.00 93.24 N \\\\nATOM 1063 NH1 ARG A 129 -15.545 -3.069 9.565 1.00 93.24 N \\\\nATOM 1064 NH2 ARG A 129 -13.654 -2.316 8.685 1.00 93.24 N \\\\nATOM 1065 CZ ARG A 129 -14.937 -2.199 8.816 1.00 93.24 C \\\\nATOM 1066 N VAL A 130 -18.379 2.493 5.228 1.00 90.59 N \\\\nATOM 1067 CA VAL A 130 -18.525 2.254 3.792 1.00 90.59 C \\\\nATOM 1068 C VAL A 130 -18.584 0.743 3.573 1.00 90.59 C \\\\nATOM 1069 CB VAL A 130 -17.388 2.919 2.995 1.00 90.59 C \\\\nATOM 1070 O VAL A 130 -17.615 0.034 3.834 1.00 90.59 O \\\\nATOM 1071 CG1 VAL A 130 -17.556 2.671 1.492 1.00 90.59 C \\\\nATOM 1072 CG2 VAL A 130 -17.383 4.441 3.214 1.00 90.59 C \\\\nATOM 1073 N GLU A 131 -19.744 0.256 3.146 1.00 83.73 N \\\\nATOM 1074 CA GLU A 131 -19.983 -1.153 2.835 1.00 83.73 C \\\\nATOM 1075 C GLU A 131 -19.492 -1.473 1.415 1.00 83.73 C \\\\nATOM 1076 CB GLU A 131 -21.480 -1.470 3.027 1.00 83.73 C \\\\nATOM 1077 O GLU A 131 -19.639 -0.659 0.501 1.00 83.73 O \\\\nATOM 1078 CG GLU A 131 -21.875 -1.449 4.519 1.00 83.73 C \\\\nATOM 1079 CD GLU A 131 -23.394 -1.409 4.770 1.00 83.73 C \\\\nATOM 1080 OE1 GLU A 131 -23.785 -0.811 5.806 1.00 83.73 O \\\\nATOM 1081 OE2 GLU A 131 -24.150 -1.953 3.938 1.00 83.73 O \\\\nATOM 1082 N THR A 132 -18.902 -2.655 1.219 1.00 81.31 N \\\\nATOM 1083 CA THR A 132 -18.564 -3.156 -0.121 1.00 81.31 C \\\\nATOM 1084 C THR A 132 -19.844 -3.639 -0.803 1.00 81.31 C \\\\nATOM 1085 CB THR A 132 -17.508 -4.271 -0.069 1.00 81.31 C \\\\nATOM 1086 O THR A 132 -20.510 -4.522 -0.257 1.00 81.31 O \\\\nATOM 1087 CG2 THR A 132 -17.101 -4.782 -1.451 1.00 81.31 C \\\\nATOM 1088 OG1 THR A 132 -16.328 -3.776 0.523 1.00 81.31 O \\\\nATOM 1089 N PRO A 133 -20.218 -3.090 -1.974 1.00 82.14 N \\\\nATOM 1090 CA PRO A 133 -21.417 -3.512 -2.676 1.00 82.14 C \\\\nATOM 1091 C PRO A 133 -21.256 -4.949 -3.177 1.00 82.14 C \\\\nATOM 1092 CB PRO A 133 -21.596 -2.513 -3.821 1.00 82.14 C \\\\nATOM 1093 O PRO A 133 -20.198 -5.332 -3.680 1.00 82.14 O \\\\nATOM 1094 CG PRO A 133 -20.167 -2.064 -4.130 1.00 82.14 C \\\\nATOM 1095 CD PRO A 133 -19.492 -2.105 -2.762 1.00 82.14 C \\\\nATOM 1096 N VAL A 134 -22.324 -5.742 -3.076 1.00 84.73 N \\\\nATOM 1097 CA VAL A 134 -22.350 -7.095 -3.640 1.00 84.73 C \\\\nATOM 1098 C VAL A 134 -22.305 -6.989 -5.163 1.00 84.73 C \\\\nATOM 1099 CB VAL A 134 -23.578 -7.896 -3.166 1.00 84.73 C \\\\nATOM 1100 O VAL A 134 -23.174 -6.370 -5.777 1.00 84.73 O \\\\nATOM 1101 CG1 VAL A 134 -23.554 -9.328 -3.718 1.00 84.73 C \\\\nATOM 1102 CG2 VAL A 134 -23.620 -7.990 -1.634 1.00 84.73 C \\\\nATOM 1103 N LEU A 135 -21.278 -7.581 -5.769 1.00 89.09 N \\\\nATOM 1104 CA LEU A 135 -21.108 -7.609 -7.219 1.00 89.09 C \\\\nATOM 1105 C LEU A 135 -21.987 -8.724 -7.819 1.00 89.09 C \\\\nATOM 1106 CB LEU A 135 -19.617 -7.789 -7.561 1.00 89.09 C \\\\nATOM 1107 O LEU A 135 -21.986 -9.837 -7.283 1.00 89.09 O \\\\nATOM 1108 CG LEU A 135 -18.693 -6.691 -6.997 1.00 89.09 C \\\\nATOM 1109 CD1 LEU A 135 -17.229 -7.061 -7.208 1.00 89.09 C \\\\nATOM 1110 CD2 LEU A 135 -18.944 -5.332 -7.652 1.00 89.09 C \\\\nATOM 1111 N PRO A 136 -22.738 -8.465 -8.907 1.00 88.64 N \\\\nATOM 1112 CA PRO A 136 -23.542 -9.495 -9.559 1.00 88.64 C \\\\nATOM 1113 C PRO A 136 -22.634 -10.566 -10.189 1.00 88.64 C \\\\nATOM 1114 CB PRO A 136 -24.372 -8.757 -10.614 1.00 88.64 C \\\\nATOM 1115 O PRO A 136 -21.542 -10.229 -10.650 1.00 88.64 O \\\\nATOM 1116 CG PRO A 136 -23.484 -7.567 -10.984 1.00 88.64 C \\\\nATOM 1117 CD PRO A 136 -22.802 -7.219 -9.660 1.00 88.64 C \\\\nATOM 1118 N PRO A 137 -23.050 -11.845 -10.241 1.00 90.23 N \\\\nATOM 1119 CA PRO A 137 -22.293 -12.873 -10.945 1.00 90.23 C \\\\nATOM 1120 C PRO A 137 -22.248 -12.582 -12.449 1.00 90.23 C \\\\nATOM 1121 CB PRO A 137 -23.010 -14.193 -10.650 1.00 90.23 C \\\\nATOM 1122 O PRO A 137 -23.247 -12.178 -13.044 1.00 90.23 O \\\\nATOM 1123 CG PRO A 137 -24.458 -13.757 -10.418 1.00 90.23 C \\\\nATOM 1124 CD PRO A 137 -24.311 -12.385 -9.756 1.00 90.23 C \\\\nATOM 1125 N VAL A 138 -21.102 -12.848 -13.072 1.00 90.43 N \\\\nATOM 1126 CA VAL A 138 -20.956 -12.812 -14.533 1.00 90.43 C \\\\nATOM 1127 C VAL A 138 -21.520 -14.113 -15.097 1.00 90.43 C \\\\nATOM 1128 CB VAL A 138 -19.483 -12.596 -14.923 1.00 90.43 C \\\\nATOM 1129 O VAL A 138 -21.149 -15.188 -14.634 1.00 90.43 O \\\\nATOM 1130 CG1 VAL A 138 -19.244 -12.761 -16.426 1.00 90.43 C \\\\nATOM 1131 CG2 VAL A 138 -19.033 -11.184 -14.531 1.00 90.43 C \\\\nATOM 1132 N LEU A 139 -22.432 -14.030 -16.064 1.00 90.13 N \\\\nATOM 1133 CA LEU A 139 -23.028 -15.201 -16.710 1.00 90.13 C \\\\nATOM 1134 C LEU A 139 -22.212 -15.571 -17.950 1.00 90.13 C \\\\nATOM 1135 CB LEU A 139 -24.497 -14.911 -17.070 1.00 90.13 C \\\\nATOM 1136 O LEU A 139 -22.111 -14.764 -18.870 1.00 90.13 O \\\\nATOM 1137 CG LEU A 139 -25.419 -14.571 -15.886 1.00 90.13 C \\\\nATOM 1138 CD1 LEU A 139 -26.852 -14.393 -16.388 1.00 90.13 C \\\\nATOM 1139 CD2 LEU A 139 -25.424 -15.658 -14.809 1.00 90.13 C \\\\nATOM 1140 N VAL A 140 -21.646 -16.777 -17.976 1.00 86.83 N \\\\nATOM 1141 CA VAL A 140 -20.816 -17.263 -19.086 1.00 86.83 C \\\\nATOM 1142 C VAL A 140 -21.594 -18.289 -19.916 1.00 86.83 C \\\\nATOM 1143 CB VAL A 140 -19.483 -17.841 -18.578 1.00 86.83 C \\\\nATOM 1144 O VAL A 140 -22.031 -19.297 -19.353 1.00 86.83 O \\\\nATOM 1145 CG1 VAL A 140 -18.603 -18.256 -19.760 1.00 86.83 C \\\\nATOM 1146 CG2 VAL A 140 -18.706 -16.789 -17.774 1.00 86.83 C \\\\nATOM 1147 N PRO A 141 -21.784 -18.080 -21.233 1.00 80.27 N \\\\nATOM 1148 CA PRO A 141 -22.358 -19.094 -22.111 1.00 80.27 C \\\\nATOM 1149 C PRO A 141 -21.443 -20.313 -22.197 1.00 80.27 C \\\\nATOM 1150 CB PRO A 141 -22.534 -18.428 -23.485 1.00 80.27 C \\\\nATOM 1151 O PRO A 141 -20.263 -20.186 -22.524 1.00 80.27 O \\\\nATOM 1152 CG PRO A 141 -22.470 -16.930 -23.190 1.00 80.27 C \\\\nATOM 1153 CD PRO A 141 -21.543 -16.855 -21.981 1.00 80.27 C \\\\nATOM 1154 N ARG A 142 -21.981 -21.514 -21.970 1.00 69.52 N \\\\nATOM 1155 CA ARG A 142 -21.269 -22.736 -22.351 1.00 69.52 C \\\\nATOM 1156 C ARG A 142 -21.185 -22.821 -23.872 1.00 69.52 C \\\\nATOM 1157 CB ARG A 142 -21.953 -23.967 -21.748 1.00 69.52 C \\\\nATOM 1158 O ARG A 142 -22.206 -22.891 -24.551 1.00 69.52 O \\\\nATOM 1159 CG ARG A 142 -21.631 -24.061 -20.254 1.00 69.52 C \\\\nATOM 1160 CD ARG A 142 -22.346 -25.257 -19.638 1.00 69.52 C \\\\nATOM 1161 NE ARG A 142 -21.928 -25.454 -18.243 1.00 69.52 N \\\\nATOM 1162 NH1 ARG A 142 -23.569 -26.951 -17.623 1.00 69.52 N \\\\nATOM 1163 NH2 ARG A 142 -21.996 -26.344 -16.175 1.00 69.52 N \\\\nATOM 1164 CZ ARG A 142 -22.504 -26.251 -17.367 1.00 69.52 C \\\\nATOM 1165 N HIS A 143 -19.965 -22.851 -24.403 1.00 60.13 N \\\\nATOM 1166 CA HIS A 143 -19.725 -23.115 -25.818 1.00 60.13 C \\\\nATOM 1167 C HIS A 143 -20.074 -24.569 -26.163 1.00 60.13 C \\\\nATOM 1168 CB HIS A 143 -18.268 -22.792 -26.187 1.00 60.13 C \\\\nATOM 1169 O HIS A 143 -19.233 -25.460 -26.058 1.00 60.13 O \\\\nATOM 1170 CG HIS A 143 -17.987 -21.319 -26.313 1.00 60.13 C \\\\nATOM 1171 CD2 HIS A 143 -17.154 -20.573 -25.523 1.00 60.13 C \\\\nATOM 1172 ND1 HIS A 143 -18.492 -20.479 -27.280 1.00 60.13 N \\\\nATOM 1173 CE1 HIS A 143 -17.978 -19.255 -27.072 1.00 60.13 C \\\\nATOM 1174 NE2 HIS A 143 -17.155 -19.264 -26.014 1.00 60.13 N \\\\nATOM 1175 N THR A 144 -21.307 -24.802 -26.609 1.00 49.08 N \\\\nATOM 1176 CA THR A 144 -21.659 -25.991 -27.399 1.00 49.08 C \\\\nATOM 1177 C THR A 144 -21.462 -25.753 -28.894 1.00 49.08 C \\\\nATOM 1178 CB THR A 144 -23.084 -26.500 -27.108 1.00 49.08 C \\\\nATOM 1179 O THR A 144 -20.954 -26.644 -29.567 1.00 49.08 O \\\\nATOM 1180 CG2 THR A 144 -23.051 -27.644 -26.096 1.00 49.08 C \\\\nATOM 1181 OG1 THR A 144 -23.908 -25.493 -26.561 1.00 49.08 O \\\\nATOM 1182 N GLU A 145 -21.785 -24.563 -29.417 1.00 43.90 N \\\\nATOM 1183 CA GLU A 145 -21.641 -24.222 -30.844 1.00 43.90 C \\\\nATOM 1184 C GLU A 145 -21.170 -22.762 -31.027 1.00 43.90 C \\\\nATOM 1185 CB GLU A 145 -22.952 -24.520 -31.606 1.00 43.90 C \\\\nATOM 1186 O GLU A 145 -21.480 -21.888 -30.216 1.00 43.90 O \\\\nATOM 1187 CG GLU A 145 -23.310 -26.023 -31.560 1.00 43.90 C \\\\nATOM 1188 CD GLU A 145 -24.548 -26.438 -32.366 1.00 43.90 C \\\\nATOM 1189 OE1 GLU A 145 -24.808 -27.663 -32.400 1.00 43.90 O \\\\nATOM 1190 OE2 GLU A 145 -25.231 -25.551 -32.922 1.00 43.90 O \\\\nATOM 1191 N ILE A 146 -20.371 -22.501 -32.070 1.00 47.79 N \\\\nATOM 1192 CA ILE A 146 -19.771 -21.185 -32.364 1.00 47.79 C \\\\nATOM 1193 C ILE A 146 -20.657 -20.445 -33.383 1.00 47.79 C \\\\nATOM 1194 CB ILE A 146 -18.323 -21.349 -32.905 1.00 47.79 C \\\\nATOM 1195 O ILE A 146 -20.850 -20.977 -34.478 1.00 47.79 O \\\\nATOM 1196 CG1 ILE A 146 -17.401 -22.045 -31.874 1.00 47.79 C \\\\nATOM 1197 CG2 ILE A 146 -17.724 -19.987 -33.308 1.00 47.79 C \\\\nATOM 1198 CD1 ILE A 146 -16.042 -22.481 -32.443 1.00 47.79 C \\\\nATOM 1199 N PRO A 147 -21.147 -19.220 -33.102 1.00 49.95 N \\\\nATOM 1200 CA PRO A 147 -21.773 -18.379 -34.121 1.00 49.95 C \\\\nATOM 1201 C PRO A 147 -20.759 -18.029 -35.219 1.00 49.95 C \\\\nATOM 1202 CB PRO A 147 -22.294 -17.133 -33.392 1.00 49.95 C \\\\nATOM 1203 O PRO A 147 -19.681 -17.514 -34.929 1.00 49.95 O \\\\nATOM 1204 CG PRO A 147 -22.374 -17.575 -31.931 1.00 49.95 C \\\\nATOM 1205 CD PRO A 147 -21.217 -18.565 -31.807 1.00 49.95 C \\\\nATOM 1206 N ALA A 148 -21.093 -18.327 -36.476 1.00 50.53 N \\\\nATOM 1207 CA ALA A 148 -20.153 -18.237 -37.599 1.00 50.53 C \\\\nATOM 1208 C ALA A 148 -19.879 -16.803 -38.099 1.00 50.53 C \\\\nATOM 1209 CB ALA A 148 -20.670 -19.141 -38.724 1.00 50.53 C \\\\nATOM 1210 O ALA A 148 -18.933 -16.601 -38.856 1.00 50.53 O \\\\nATOM 1211 N GLU A 149 -20.677 -15.819 -37.678 1.00 41.11 N \\\\nATOM 1212 CA GLU A 149 -20.536 -14.413 -38.062 1.00 41.11 C \\\\nATOM 1213 C GLU A 149 -20.661 -13.519 -36.822 1.00 41.11 C \\\\nATOM 1214 CB GLU A 149 -21.581 -14.032 -39.128 1.00 41.11 C \\\\nATOM 1215 O GLU A 149 -21.689 -13.507 -36.145 1.00 41.11 O \\\\nATOM 1216 CG GLU A 149 -21.326 -14.731 -40.475 1.00 41.11 C \\\\nATOM 1217 CD GLU A 149 -22.336 -14.338 -41.566 1.00 41.11 C \\\\nATOM 1218 OE1 GLU A 149 -21.917 -14.275 -42.745 1.00 41.11 O \\\\nATOM 1219 OE2 GLU A 149 -23.526 -14.141 -41.230 1.00 41.11 O \\\\nATOM 1220 N PHE A 150 -19.607 -12.752 -36.542 1.00 50.90 N \\\\nATOM 1221 CA PHE A 150 -19.629 -11.622 -35.614 1.00 50.90 C \\\\nATOM 1222 C PHE A 150 -19.395 -10.328 -36.409 1.00 50.90 C \\\\nATOM 1223 CB PHE A 150 -18.581 -11.808 -34.505 1.00 50.90 C \\\\nATOM 1224 O PHE A 150 -18.740 -10.377 -37.456 1.00 50.90 O \\\\nATOM 1225 CG PHE A 150 -18.997 -12.783 -33.417 1.00 50.90 C \\\\nATOM 1226 CD1 PHE A 150 -19.693 -12.318 -32.284 1.00 50.90 C \\\\nATOM 1227 CD2 PHE A 150 -18.701 -14.154 -33.536 1.00 50.90 C \\\\nATOM 1228 CE1 PHE A 150 -20.083 -13.215 -31.273 1.00 50.90 C \\\\nATOM 1229 CE2 PHE A 150 -19.093 -15.053 -32.528 1.00 50.90 C \\\\nATOM 1230 CZ PHE A 150 -19.783 -14.584 -31.395 1.00 50.90 C \\\\nATOM 1231 N PRO A 151 -19.893 -9.167 -35.939 1.00 45.48 N \\\\nATOM 1232 CA PRO A 151 -19.538 -7.879 -36.527 1.00 45.48 C \\\\nATOM 1233 C PRO A 151 -18.012 -7.690 -36.531 1.00 45.48 C \\\\nATOM 1234 CB PRO A 151 -20.222 -6.811 -35.664 1.00 45.48 C \\\\nATOM 1235 O PRO A 151 -17.342 -8.232 -35.645 1.00 45.48 O \\\\nATOM 1236 CG PRO A 151 -21.324 -7.575 -34.931 1.00 45.48 C \\\\nATOM 1237 CD PRO A 151 -20.732 -8.972 -34.769 1.00 45.48 C \\\\nATOM 1238 N PRO A 152 -17.448 -6.916 -37.477 1.00 43.35 N \\\\nATOM 1239 CA PRO A 152 -16.029 -6.596 -37.439 1.00 43.35 C \\\\nATOM 1240 C PRO A 152 -15.691 -5.935 -36.098 1.00 43.35 C \\\\nATOM 1241 CB PRO A 152 -15.767 -5.682 -38.642 1.00 43.35 C \\\\nATOM 1242 O PRO A 152 -16.322 -4.956 -35.703 1.00 43.35 O \\\\nATOM 1243 CG PRO A 152 -17.138 -5.077 -38.950 1.00 43.35 C \\\\nATOM 1244 CD PRO A 152 -18.120 -6.171 -38.530 1.00 43.35 C \\\\nATOM 1245 N LEU A 153 -14.708 -6.500 -35.396 1.00 46.99 N \\\\nATOM 1246 CA LEU A 153 -14.107 -5.858 -34.233 1.00 46.99 C \\\\nATOM 1247 C LEU A 153 -13.436 -4.565 -34.703 1.00 46.99 C \\\\nATOM 1248 CB LEU A 153 -13.072 -6.804 -33.587 1.00 46.99 C \\\\nATOM 1249 O LEU A 153 -12.665 -4.599 -35.664 1.00 46.99 O \\\\nATOM 1250 CG LEU A 153 -13.670 -8.031 -32.874 1.00 46.99 C \\\\nATOM 1251 CD1 LEU A 153 -12.566 -9.043 -32.557 1.00 46.99 C \\\\nATOM 1252 CD2 LEU A 153 -14.346 -7.649 -31.554 1.00 46.99 C \\\\nATOM 1253 N ASP A 154 -13.695 -3.453 -34.013 1.00 44.28 N \\\\nATOM 1254 CA ASP A 154 -12.870 -2.256 -34.164 1.00 44.28 C \\\\nATOM 1255 C ASP A 154 -11.413 -2.634 -33.881 1.00 44.28 C \\\\nATOM 1256 CB ASP A 154 -13.326 -1.135 -33.215 1.00 44.28 C \\\\nATOM 1257 O ASP A 154 -11.113 -3.281 -32.870 1.00 44.28 O \\\\nATOM 1258 CG ASP A 154 -14.562 -0.385 -33.716 1.00 44.28 C \\\\nATOM 1259 OD1 ASP A 154 -14.599 -0.065 -34.926 1.00 44.28 O \\\\nATOM 1260 OD2 ASP A 154 -15.441 -0.101 -32.871 1.00 44.28 O \\\\nATOM 1261 N ASP A 155 -10.504 -2.262 -34.786 1.00 39.25 N \\\\nATOM 1262 CA ASP A 155 -9.109 -2.671 -34.676 1.00 39.25 C \\\\nATOM 1263 C ASP A 155 -8.376 -1.873 -33.589 1.00 39.25 C \\\\nATOM 1264 CB ASP A 155 -8.374 -2.672 -36.023 1.00 39.25 C \\\\nATOM 1265 O ASP A 155 -7.690 -0.873 -33.821 1.00 39.25 O \\\\nATOM 1266 CG ASP A 155 -6.969 -3.266 -35.845 1.00 39.25 C \\\\nATOM 1267 OD1 ASP A 155 -6.731 -3.949 -34.821 1.00 39.25 O \\\\nATOM 1268 OD2 ASP A 155 -6.084 -3.012 -36.687 1.00 39.25 O \\\\nATOM 1269 N TYR A 156 -8.500 -2.367 -32.362 1.00 43.30 N \\\\nATOM 1270 CA TYR A 156 -7.770 -1.886 -31.202 1.00 43.30 C \\\\nATOM 1271 C TYR A 156 -6.262 -2.222 -31.252 1.00 43.30 C \\\\nATOM 1272 CB TYR A 156 -8.485 -2.362 -29.921 1.00 43.30 C \\\\nATOM 1273 O TYR A 156 -5.565 -1.899 -30.285 1.00 43.30 O \\\\nATOM 1274 CG TYR A 156 -9.726 -1.555 -29.566 1.00 43.30 C \\\\nATOM 1275 CD1 TYR A 156 -9.599 -0.300 -28.937 1.00 43.30 C \\\\nATOM 1276 CD2 TYR A 156 -11.012 -2.049 -29.857 1.00 43.30 C \\\\nATOM 1277 CE1 TYR A 156 -10.733 0.470 -28.621 1.00 43.30 C \\\\nATOM 1278 CE2 TYR A 156 -12.154 -1.294 -29.526 1.00 43.30 C \\\\nATOM 1279 OH TYR A 156 -13.120 0.694 -28.593 1.00 43.30 O \\\\nATOM 1280 CZ TYR A 156 -12.018 -0.032 -28.914 1.00 43.30 C \\\\nATOM 1281 N SER A 157 -5.703 -2.776 -32.343 1.00 44.03 N \\\\nATOM 1282 CA SER A 157 -4.243 -2.892 -32.529 1.00 44.03 C \\\\nATOM 1283 C SER A 157 -3.537 -1.535 -32.392 1.00 44.03 C \\\\nATOM 1284 CB SER A 157 -3.889 -3.535 -33.881 1.00 44.03 C \\\\nATOM 1285 O SER A 157 -2.504 -1.435 -31.732 1.00 44.03 O \\\\nATOM 1286 OG SER A 157 -4.039 -2.628 -34.955 1.00 44.03 O \\\\nATOM 1287 N HIS A 158 -4.160 -0.458 -32.880 1.00 38.34 N \\\\nATOM 1288 CA HIS A 158 -3.667 0.916 -32.739 1.00 38.34 C \\\\nATOM 1289 C HIS A 158 -3.891 1.533 -31.347 1.00 38.34 C \\\\nATOM 1290 CB HIS A 158 -4.280 1.774 -33.850 1.00 38.34 C \\\\nATOM 1291 O HIS A 158 -3.365 2.606 -31.059 1.00 38.34 O \\\\nATOM 1292 CG HIS A 158 -3.831 1.351 -35.226 1.00 38.34 C \\\\nATOM 1293 CD2 HIS A 158 -4.630 1.066 -36.301 1.00 38.34 C \\\\nATOM 1294 ND1 HIS A 158 -2.527 1.162 -35.629 1.00 38.34 N \\\\nATOM 1295 CE1 HIS A 158 -2.543 0.778 -36.915 1.00 38.34 C \\\\nATOM 1296 NE2 HIS A 158 -3.798 0.739 -37.379 1.00 38.34 N \\\\nATOM 1297 N SER A 159 -4.625 0.858 -30.456 1.00 38.83 N \\\\nATOM 1298 CA SER A 159 -4.744 1.260 -29.046 1.00 38.83 C \\\\nATOM 1299 C SER A 159 -3.651 0.669 -28.154 1.00 38.83 C \\\\nATOM 1300 CB SER A 159 -6.123 0.917 -28.499 1.00 38.83 C \\\\nATOM 1301 O SER A 159 -3.557 1.043 -26.982 1.00 38.83 O \\\\nATOM 1302 OG SER A 159 -6.218 -0.454 -28.156 1.00 38.83 O \\\\nATOM 1303 N ILE A 160 -2.822 -0.242 -28.689 1.00 40.21 N \\\\nATOM 1304 CA ILE A 160 -1.624 -0.744 -28.015 1.00 40.21 C \\\\nATOM 1305 C ILE A 160 -0.648 0.430 -27.888 1.00 40.21 C \\\\nATOM 1306 CB ILE A 160 -0.969 -1.918 -28.780 1.00 40.21 C \\\\nATOM 1307 O ILE A 160 -0.074 0.861 -28.888 1.00 40.21 O \\\\nATOM 1308 CG1 ILE A 160 -1.959 -3.092 -28.956 1.00 40.21 C \\\\nATOM 1309 CG2 ILE A 160 0.289 -2.393 -28.019 1.00 40.21 C \\\\nATOM 1310 CD1 ILE A 160 -1.440 -4.208 -29.872 1.00 40.21 C \\\\nATOM 1311 N PRO A 161 -0.412 0.962 -26.681 1.00 43.58 N \\\\nATOM 1312 CA PRO A 161 0.552 2.023 -26.524 1.00 43.58 C \\\\nATOM 1313 C PRO A 161 1.932 1.384 -26.370 1.00 43.58 C \\\\nATOM 1314 CB PRO A 161 0.068 2.791 -25.297 1.00 43.58 C \\\\nATOM 1315 O PRO A 161 2.152 0.600 -25.449 1.00 43.58 O \\\\nATOM 1316 CG PRO A 161 -0.750 1.782 -24.475 1.00 43.58 C \\\\nATOM 1317 CD PRO A 161 -0.924 0.562 -25.378 1.00 43.58 C \\\\nATOM 1318 N GLU A 162 2.907 1.787 -27.186 1.00 51.97 N \\\\nATOM 1319 CA GLU A 162 4.313 1.330 -27.096 1.00 51.97 C \\\\nATOM 1320 C GLU A 162 4.959 1.568 -25.708 1.00 51.97 C \\\\nATOM 1321 CB GLU A 162 5.148 2.041 -28.171 1.00 51.97 C \\\\nATOM 1322 O GLU A 162 6.053 1.091 -25.403 1.00 51.97 O \\\\nATOM 1323 CG GLU A 162 4.705 1.733 -29.611 1.00 51.97 C \\\\nATOM 1324 CD GLU A 162 5.627 2.428 -30.624 1.00 51.97 C \\\\nATOM 1325 OE1 GLU A 162 6.049 1.755 -31.589 1.00 51.97 O \\\\nATOM 1326 OE2 GLU A 162 5.927 3.624 -30.395 1.00 51.97 O \\\\nATOM 1327 N ASN A 163 4.263 2.268 -24.805 1.00 55.17 N \\\\nATOM 1328 CA ASN A 163 4.623 2.384 -23.398 1.00 55.17 C \\\\nATOM 1329 C ASN A 163 4.496 1.090 -22.566 1.00 55.17 C \\\\nATOM 1330 CB ASN A 163 3.936 3.622 -22.785 1.00 55.17 C \\\\nATOM 1331 O ASN A 163 4.902 1.119 -21.402 1.00 55.17 O \\\\nATOM 1332 CG ASN A 163 2.443 3.565 -22.528 1.00 55.17 C \\\\nATOM 1333 ND2 ASN A 163 1.793 4.704 -22.602 1.00 55.17 N \\\\nATOM 1334 OD1 ASN A 163 1.852 2.571 -22.154 1.00 55.17 O \\\\nATOM 1335 N THR A 164 4.011 -0.025 -23.135 1.00 50.75 N \\\\nATOM 1336 CA THR A 164 3.756 -1.293 -22.421 1.00 50.75 C \\\\nATOM 1337 C THR A 164 4.792 -2.411 -22.609 1.00 50.75 C \\\\nATOM 1338 CB THR A 164 2.345 -1.846 -22.708 1.00 50.75 C \\\\nATOM 1339 O THR A 164 4.489 -3.547 -22.245 1.00 50.75 O \\\\nATOM 1340 CG2 THR A 164 1.248 -0.843 -22.368 1.00 50.75 C \\\\nATOM 1341 OG1 THR A 164 2.175 -2.204 -24.057 1.00 50.75 O \\\\nATOM 1342 N ASN A 165 5.985 -2.158 -23.162 1.00 46.01 N \\\\nATOM 1343 CA ASN A 165 6.958 -3.231 -23.437 1.00 46.01 C \\\\nATOM 1344 C ASN A 165 7.416 -3.989 -22.172 1.00 46.01 C \\\\nATOM 1345 CB ASN A 165 8.159 -2.701 -24.250 1.00 46.01 C \\\\nATOM 1346 O ASN A 165 8.296 -3.539 -21.434 1.00 46.01 O \\\\nATOM 1347 CG ASN A 165 7.840 -2.535 -25.727 1.00 46.01 C \\\\nATOM 1348 ND2 ASN A 165 8.836 -2.447 -26.576 1.00 46.01 N \\\\nATOM 1349 OD1 ASN A 165 6.696 -2.500 -26.135 1.00 46.01 O \\\\nATOM 1350 N PHE A 166 6.859 -5.189 -21.983 1.00 39.23 N \\\\nATOM 1351 CA PHE A 166 7.439 -6.247 -21.160 1.00 39.23 C \\\\nATOM 1352 C PHE A 166 8.686 -6.815 -21.859 1.00 39.23 C \\\\nATOM 1353 CB PHE A 166 6.422 -7.383 -20.959 1.00 39.23 C \\\\nATOM 1354 O PHE A 166 8.648 -7.028 -23.072 1.00 39.23 O \\\\nATOM 1355 CG PHE A 166 5.298 -7.094 -19.983 1.00 39.23 C \\\\nATOM 1356 CD1 PHE A 166 5.477 -7.366 -18.612 1.00 39.23 C \\\\nATOM 1357 CD2 PHE A 166 4.061 -6.601 -20.440 1.00 39.23 C \\\\nATOM 1358 CE1 PHE A 166 4.427 -7.142 -17.704 1.00 39.23 C \\\\nATOM 1359 CE2 PHE A 166 3.004 -6.398 -19.533 1.00 39.23 C \\\\nATOM 1360 CZ PHE A 166 3.188 -6.666 -18.165 1.00 39.23 C \\\\nATOM 1361 N PRO A 167 9.773 -7.129 -21.133 1.00 38.71 N \\\\nATOM 1362 CA PRO A 167 10.925 -7.804 -21.715 1.00 38.71 C \\\\nATOM 1363 C PRO A 167 10.655 -9.311 -21.872 1.00 38.71 C \\\\nATOM 1364 CB PRO A 167 12.089 -7.465 -20.778 1.00 38.71 C \\\\nATOM 1365 O PRO A 167 11.086 -10.120 -21.052 1.00 38.71 O \\\\nATOM 1366 CG PRO A 167 11.413 -7.359 -19.411 1.00 38.71 C \\\\nATOM 1367 CD PRO A 167 10.026 -6.799 -19.738 1.00 38.71 C \\\\nATOM 1368 N ALA A 168 9.985 -9.694 -22.961 1.00 35.78 N \\\\nATOM 1369 CA ALA A 168 10.348 -10.935 -23.644 1.00 35.78 C \\\\nATOM 1370 C ALA A 168 11.684 -10.665 -24.361 1.00 35.78 C \\\\nATOM 1371 CB ALA A 168 9.221 -11.358 -24.591 1.00 35.78 C \\\\nATOM 1372 O ALA A 168 11.835 -9.631 -25.011 1.00 35.78 O \\\\nATOM 1373 N GLY A 169 12.697 -11.498 -24.123 1.00 29.87 N \\\\nATOM 1374 CA GLY A 169 14.087 -11.107 -24.379 1.00 29.87 C \\\\nATOM 1375 C GLY A 169 14.470 -11.009 -25.859 1.00 29.87 C \\\\nATOM 1376 O GLY A 169 14.032 -11.835 -26.648 1.00 29.87 O \\\\nATOM 1377 N ILE A 170 15.332 -10.035 -26.181 1.00 36.65 N \\\\nATOM 1378 CA ILE A 170 16.510 -10.086 -27.078 1.00 36.65 C \\\\nATOM 1379 C ILE A 170 17.256 -8.728 -26.959 1.00 36.65 C \\\\nATOM 1380 CB ILE A 170 16.148 -10.534 -28.525 1.00 36.65 C \\\\nATOM 1381 O ILE A 170 16.703 -7.734 -26.495 1.00 36.65 O \\\\nATOM 1382 CG1 ILE A 170 16.237 -12.082 -28.648 1.00 36.65 C \\\\nATOM 1383 CG2 ILE A 170 17.054 -9.959 -29.631 1.00 36.65 C \\\\nATOM 1384 CD1 ILE A 170 15.229 -12.665 -29.647 1.00 36.65 C \\\\nATOM 1385 N GLU A 171 18.553 -8.749 -27.253 1.00 33.34 N \\\\nATOM 1386 CA GLU A 171 19.647 -7.827 -26.886 1.00 33.34 C \\\\nATOM 1387 C GLU A 171 19.508 -6.322 -27.262 1.00 33.34 C \\\\nATOM 1388 CB GLU A 171 20.912 -8.384 -27.563 1.00 33.34 C \\\\nATOM 1389 O GLU A 171 18.815 -5.979 -28.219 1.00 33.34 O \\\\nATOM 1390 CG GLU A 171 21.205 -9.850 -27.182 1.00 33.34 C \\\\nATOM 1391 CD GLU A 171 22.413 -10.424 -27.929 1.00 33.34 C \\\\nATOM 1392 OE1 GLU A 171 23.174 -11.173 -27.278 1.00 33.34 O \\\\nATOM 1393 OE2 GLU A 171 22.553 -10.127 -29.136 1.00 33.34 O \\\\nATOM 1394 N PRO A 172 20.211 -5.394 -26.564 1.00 32.49 N \\\\nATOM 1395 CA PRO A 172 20.148 -3.952 -26.836 1.00 32.49 C \\\\nATOM 1396 C PRO A 172 21.300 -3.415 -27.713 1.00 32.49 C \\\\nATOM 1397 CB PRO A 172 20.199 -3.318 -25.443 1.00 32.49 C \\\\nATOM 1398 O PRO A 172 22.469 -3.712 -27.466 1.00 32.49 O \\\\nATOM 1399 CG PRO A 172 21.162 -4.236 -24.683 1.00 32.49 C \\\\nATOM 1400 CD PRO A 172 20.926 -5.616 -25.309 1.00 32.49 C \\\\nATOM 1401 N GLN A 173 21.001 -2.487 -28.635 1.00 36.11 N \\\\nATOM 1402 CA GLN A 173 22.011 -1.656 -29.317 1.00 36.11 C \\\\nATOM 1403 C GLN A 173 21.726 -0.141 -29.211 1.00 36.11 C \\\\nATOM 1404 CB GLN A 173 22.234 -2.115 -30.772 1.00 36.11 C \\\\nATOM 1405 O GLN A 173 20.910 0.426 -29.924 1.00 36.11 O \\\\nATOM 1406 CG GLN A 173 23.064 -3.412 -30.836 1.00 36.11 C \\\\nATOM 1407 CD GLN A 173 23.549 -3.774 -32.240 1.00 36.11 C \\\\nATOM 1408 NE2 GLN A 173 24.380 -4.785 -32.370 1.00 36.11 N \\\\nATOM 1409 OE1 GLN A 173 23.215 -3.168 -33.243 1.00 36.11 O \\\\nATOM 1410 N SER A 174 22.463 0.497 -28.294 1.00 35.78 N \\\\nATOM 1411 CA SER A 174 23.201 1.768 -28.464 1.00 35.78 C \\\\nATOM 1412 C SER A 174 22.584 3.014 -29.161 1.00 35.78 C \\\\nATOM 1413 CB SER A 174 24.544 1.424 -29.129 1.00 35.78 C \\\\nATOM 1414 O SER A 174 22.504 3.069 -30.383 1.00 35.78 O \\\\nATOM 1415 OG SER A 174 24.359 0.851 -30.404 1.00 35.78 O \\\\nATOM 1416 N ASN A 175 22.484 4.104 -28.369 1.00 35.08 N \\\\nATOM 1417 CA ASN A 175 23.258 5.374 -28.501 1.00 35.08 C \\\\nATOM 1418 C ASN A 175 22.610 6.746 -28.897 1.00 35.08 C \\\\nATOM 1419 CB ASN A 175 24.603 5.154 -29.250 1.00 35.08 C \\\\nATOM 1420 O ASN A 175 22.404 7.013 -30.071 1.00 35.08 O \\\\nATOM 1421 CG ASN A 175 25.726 4.615 -28.377 1.00 35.08 C \\\\nATOM 1422 ND2 ASN A 175 26.864 4.315 -28.954 1.00 35.08 N \\\\nATOM 1423 OD1 ASN A 175 25.602 4.449 -27.175 1.00 35.08 O \\\\nATOM 1424 N ILE A 176 22.622 7.684 -27.909 1.00 42.21 N \\\\nATOM 1425 CA ILE A 176 23.071 9.121 -27.980 1.00 42.21 C \\\\nATOM 1426 C ILE A 176 22.116 10.155 -28.683 1.00 42.21 C \\\\nATOM 1427 CB ILE A 176 24.533 9.124 -28.560 1.00 42.21 C \\\\nATOM 1428 O ILE A 176 21.554 9.825 -29.717 1.00 42.21 O \\\\nATOM 1429 CG1 ILE A 176 25.528 8.202 -27.803 1.00 42.21 C \\\\nATOM 1430 CG2 ILE A 176 25.248 10.481 -28.601 1.00 42.21 C \\\\nATOM 1431 CD1 ILE A 176 26.821 7.896 -28.587 1.00 42.21 C \\\\nATOM 1432 N PRO A 177 21.984 11.451 -28.260 1.00 34.10 N \\\\nATOM 1433 CA PRO A 177 21.878 12.076 -26.925 1.00 34.10 C \\\\nATOM 1434 C PRO A 177 20.748 13.164 -26.840 1.00 34.10 C \\\\nATOM 1435 CB PRO A 177 23.238 12.758 -26.772 1.00 34.10 C \\\\nATOM 1436 O PRO A 177 19.832 13.216 -27.651 1.00 34.10 O \\\\nATOM 1437 CG PRO A 177 23.430 13.356 -28.173 1.00 34.10 C \\\\nATOM 1438 CD PRO A 177 22.508 12.528 -29.094 1.00 34.10 C \\\\nATOM 1439 N GLU A 178 20.803 14.056 -25.840 1.00 31.22 N \\\\nATOM 1440 CA GLU A 178 19.766 15.049 -25.493 1.00 31.22 C \\\\nATOM 1441 C GLU A 178 19.873 16.441 -26.160 1.00 31.22 C \\\\nATOM 1442 CB GLU A 178 19.800 15.310 -23.972 1.00 31.22 C \\\\nATOM 1443 O GLU A 178 20.954 17.024 -26.197 1.00 31.22 O \\\\nATOM 1444 CG GLU A 178 19.939 14.061 -23.097 1.00 31.22 C \\\\nATOM 1445 CD GLU A 178 19.667 14.394 -21.630 1.00 31.22 C \\\\nATOM 1446 OE1 GLU A 178 18.475 14.276 -21.249 1.00 31.22 O \\\\nATOM 1447 OE2 GLU A 178 20.612 14.760 -20.908 1.00 31.22 O \\\\nATOM 1448 N THR A 179 18.718 17.054 -26.467 1.00 36.45 N \\\\nATOM 1449 CA THR A 179 18.493 18.520 -26.512 1.00 36.45 C \\\\nATOM 1450 C THR A 179 17.057 18.880 -26.052 1.00 36.45 C \\\\nATOM 1451 CB THR A 179 18.724 19.135 -27.909 1.00 36.45 C \\\\nATOM 1452 O THR A 179 16.109 18.175 -26.403 1.00 36.45 O \\\\nATOM 1453 CG2 THR A 179 20.193 19.431 -28.204 1.00 36.45 C \\\\nATOM 1454 OG1 THR A 179 18.255 18.284 -28.926 1.00 36.45 O \\\\nATOM 1455 N PRO A 180 16.865 19.933 -25.227 1.00 38.72 N \\\\nATOM 1456 CA PRO A 180 15.547 20.523 -24.897 1.00 38.72 C \\\\nATOM 1457 C PRO A 180 15.526 22.074 -25.039 1.00 38.72 C \\\\nATOM 1458 CB PRO A 180 15.411 20.132 -23.420 1.00 38.72 C \\\\nATOM 1459 O PRO A 180 16.585 22.664 -25.249 1.00 38.72 O \\\\nATOM 1460 CG PRO A 180 16.821 20.396 -22.876 1.00 38.72 C \\\\nATOM 1461 CD PRO A 180 17.742 20.136 -24.075 1.00 38.72 C \\\\nATOM 1462 N PRO A 181 14.425 22.785 -24.695 1.00 44.75 N \\\\nATOM 1463 CA PRO A 181 12.998 22.573 -24.970 1.00 44.75 C \\\\nATOM 1464 C PRO A 181 12.578 23.642 -26.037 1.00 44.75 C \\\\nATOM 1465 CB PRO A 181 12.406 22.621 -23.564 1.00 44.75 C \\\\nATOM 1466 O PRO A 181 13.211 23.555 -27.088 1.00 44.75 O \\\\nATOM 1467 CG PRO A 181 13.195 23.757 -22.893 1.00 44.75 C \\\\nATOM 1468 CD PRO A 181 14.509 23.832 -23.686 1.00 44.75 C \\\\nATOM 1469 N PRO A 182 11.679 24.667 -25.892 1.00 38.69 N \\\\nATOM 1470 CA PRO A 182 10.580 25.008 -24.958 1.00 38.69 C \\\\nATOM 1471 C PRO A 182 9.177 24.739 -25.580 1.00 38.69 C \\\\nATOM 1472 CB PRO A 182 10.839 26.493 -24.650 1.00 38.69 C \\\\nATOM 1473 O PRO A 182 9.040 23.844 -26.406 1.00 38.69 O \\\\nATOM 1474 CG PRO A 182 11.386 27.063 -25.956 1.00 38.69 C \\\\nATOM 1475 CD PRO A 182 11.791 25.833 -26.773 1.00 38.69 C \\\\nATOM 1476 N GLY A 183 8.136 25.483 -25.169 1.00 30.01 N \\\\nATOM 1477 CA GLY A 183 6.812 25.582 -25.824 1.00 30.01 C \\\\nATOM 1478 C GLY A 183 6.240 27.004 -25.675 1.00 30.01 C \\\\nATOM 1479 O GLY A 183 6.944 27.820 -25.092 1.00 30.01 O \\\\nATOM 1480 N TYR A 184 5.022 27.310 -26.155 1.00 39.51 N \\\\nATOM 1481 CA TYR A 184 4.191 28.473 -25.752 1.00 39.51 C \\\\nATOM 1482 C TYR A 184 2.738 28.354 -26.304 1.00 39.51 C \\\\nATOM 1483 CB TYR A 184 4.832 29.829 -26.159 1.00 39.51 C \\\\nATOM 1484 O TYR A 184 2.514 27.690 -27.308 1.00 39.51 O \\\\nATOM 1485 CG TYR A 184 5.058 30.825 -25.014 1.00 39.51 C \\\\nATOM 1486 CD1 TYR A 184 4.208 31.938 -24.856 1.00 39.51 C \\\\nATOM 1487 CD2 TYR A 184 6.147 30.684 -24.126 1.00 39.51 C \\\\nATOM 1488 CE1 TYR A 184 4.418 32.858 -23.805 1.00 39.51 C \\\\nATOM 1489 CE2 TYR A 184 6.360 31.588 -23.072 1.00 39.51 C \\\\nATOM 1490 OH TYR A 184 5.701 33.561 -21.892 1.00 39.51 O \\\\nATOM 1491 CZ TYR A 184 5.489 32.680 -22.905 1.00 39.51 C \\\\nATOM 1492 N LEU A 185 1.807 28.987 -25.580 1.00 35.19 N \\\\nATOM 1493 CA LEU A 185 0.381 29.350 -25.789 1.00 35.19 C \\\\nATOM 1494 C LEU A 185 -0.415 29.022 -27.091 1.00 35.19 C \\\\nATOM 1495 CB LEU A 185 0.305 30.876 -25.571 1.00 35.19 C \\\\nATOM 1496 O LEU A 185 -0.010 29.385 -28.186 1.00 35.19 O \\\\nATOM 1497 CG LEU A 185 0.771 31.371 -24.187 1.00 35.19 C \\\\nATOM 1498 CD1 LEU A 185 0.821 32.896 -24.155 1.00 35.19 C \\\\nATOM 1499 CD2 LEU A 185 -0.152 30.898 -23.064 1.00 35.19 C \\\\nATOM 1500 N SER A 186 -1.622 28.473 -26.858 1.00 34.39 N \\\\nATOM 1501 CA SER A 186 -2.988 28.878 -27.296 1.00 34.39 C \\\\nATOM 1502 C SER A 186 -3.303 29.479 -28.681 1.00 34.39 C \\\\nATOM 1503 CB SER A 186 -3.534 29.907 -26.294 1.00 34.39 C \\\\nATOM 1504 O SER A 186 -2.736 30.504 -29.031 1.00 34.39 O \\\\nATOM 1505 OG SER A 186 -3.317 29.516 -24.945 1.00 34.39 O \\\\nATOM 1506 N GLU A 187 -4.399 29.001 -29.302 1.00 39.49 N \\\\nATOM 1507 CA GLU A 187 -5.525 29.837 -29.798 1.00 39.49 C \\\\nATOM 1508 C GLU A 187 -6.809 29.001 -30.054 1.00 39.49 C \\\\nATOM 1509 CB GLU A 187 -5.139 30.702 -31.023 1.00 39.49 C \\\\nATOM 1510 O GLU A 187 -6.735 27.781 -30.217 1.00 39.49 O \\\\nATOM 1511 CG GLU A 187 -5.129 32.188 -30.606 1.00 39.49 C \\\\nATOM 1512 CD GLU A 187 -4.650 33.164 -31.695 1.00 39.49 C \\\\nATOM 1513 OE1 GLU A 187 -5.250 34.262 -31.783 1.00 39.49 O \\\\nATOM 1514 OE2 GLU A 187 -3.662 32.854 -32.400 1.00 39.49 O \\\\nATOM 1515 N ASP A 188 -7.981 29.651 -30.011 1.00 34.92 N \\\\nATOM 1516 CA ASP A 188 -9.330 29.047 -29.984 1.00 34.92 C \\\\nATOM 1517 C ASP A 188 -9.981 28.853 -31.376 1.00 34.92 C \\\\nATOM 1518 CB ASP A 188 -10.245 29.934 -29.116 1.00 34.92 C \\\\nATOM 1519 O ASP A 188 -9.538 29.415 -32.378 1.00 34.92 O \\\\nATOM 1520 CG ASP A 188 -9.788 30.022 -27.658 1.00 34.92 C \\\\nATOM 1521 OD1 ASP A 188 -9.987 29.023 -26.931 1.00 34.92 O \\\\nATOM 1522 OD2 ASP A 188 -9.236 31.080 -27.276 1.00 34.92 O \\\\nATOM 1523 N GLY A 189 -11.098 28.109 -31.437 1.00 37.79 N \\\\nATOM 1524 CA GLY A 189 -11.931 27.992 -32.644 1.00 37.79 C \\\\nATOM 1525 C GLY A 189 -13.313 27.363 -32.408 1.00 37.79 C \\\\nATOM 1526 O GLY A 189 -13.435 26.143 -32.331 1.00 37.79 O \\\\nATOM 1527 N GLU A 190 -14.361 28.192 -32.341 1.00 33.29 N \\\\nATOM 1528 CA GLU A 190 -15.779 27.783 -32.283 1.00 33.29 C \\\\nATOM 1529 C GLU A 190 -16.458 27.848 -33.669 1.00 33.29 C \\\\nATOM 1530 CB GLU A 190 -16.569 28.709 -31.334 1.00 33.29 C \\\\nATOM 1531 O GLU A 190 -16.091 28.687 -34.487 1.00 33.29 O \\\\nATOM 1532 CG GLU A 190 -16.107 28.723 -29.870 1.00 33.29 C \\\\nATOM 1533 CD GLU A 190 -17.007 29.639 -29.018 1.00 33.29 C \\\\nATOM 1534 OE1 GLU A 190 -17.574 29.139 -28.019 1.00 33.29 O \\\\nATOM 1535 OE2 GLU A 190 -17.140 30.831 -29.380 1.00 33.29 O \\\\nATOM 1536 N THR A 191 -17.458 26.990 -33.929 1.00 42.71 N \\\\nATOM 1537 CA THR A 191 -18.598 27.103 -34.895 1.00 42.71 C \\\\nATOM 1538 C THR A 191 -19.276 25.716 -35.016 1.00 42.71 C \\\\nATOM 1539 CB THR A 191 -18.207 27.533 -36.336 1.00 42.71 C \\\\nATOM 1540 O THR A 191 -18.584 24.710 -34.902 1.00 42.71 O \\\\nATOM 1541 CG2 THR A 191 -18.196 29.048 -36.589 1.00 42.71 C \\\\nATOM 1542 OG1 THR A 191 -16.938 27.058 -36.710 1.00 42.71 O \\\\nATOM 1543 N SER A 192 -20.579 25.502 -35.263 1.00 40.70 N \\\\nATOM 1544 CA SER A 192 -21.818 26.304 -35.160 1.00 40.70 C \\\\nATOM 1545 C SER A 192 -23.040 25.348 -35.172 1.00 40.70 C \\\\nATOM 1546 CB SER A 192 -21.980 27.261 -36.348 1.00 40.70 C \\\\nATOM 1547 O SER A 192 -22.941 24.232 -35.679 1.00 40.70 O \\\\nATOM 1548 OG SER A 192 -21.283 28.465 -36.112 1.00 40.70 O \\\\nATOM 1549 N ASP A 193 -24.191 25.782 -34.643 1.00 32.70 N \\\\nATOM 1550 CA ASP A 193 -25.446 25.002 -34.558 1.00 32.70 C \\\\nATOM 1551 C ASP A 193 -26.161 24.721 -35.895 1.00 32.70 C \\\\nATOM 1552 CB ASP A 193 -26.463 25.781 -33.704 1.00 32.70 C \\\\nATOM 1553 O ASP A 193 -26.122 25.534 -36.818 1.00 32.70 O \\\\nATOM 1554 CG ASP A 193 -26.155 25.743 -32.216 1.00 32.70 C \\\\nATOM 1555 OD1 ASP A 193 -26.245 24.629 -31.656 1.00 32.70 O \\\\nATOM 1556 OD2 ASP A 193 -25.885 26.830 -31.664 1.00 32.70 O \\\\nATOM 1557 N HIS A 194 -26.991 23.664 -35.917 1.00 43.62 N \\\\nATOM 1558 CA HIS A 194 -28.169 23.580 -36.797 1.00 43.62 C \\\\nATOM 1559 C HIS A 194 -29.393 22.927 -36.111 1.00 43.62 C \\\\nATOM 1560 CB HIS A 194 -27.822 22.876 -38.123 1.00 43.62 C \\\\nATOM 1561 O HIS A 194 -29.395 21.740 -35.792 1.00 43.62 O \\\\nATOM 1562 CG HIS A 194 -27.307 23.818 -39.187 1.00 43.62 C \\\\nATOM 1563 CD2 HIS A 194 -26.093 23.766 -39.821 1.00 43.62 C \\\\nATOM 1564 ND1 HIS A 194 -27.980 24.906 -39.701 1.00 43.62 N \\\\nATOM 1565 CE1 HIS A 194 -27.186 25.497 -40.608 1.00 43.62 C \\\\nATOM 1566 NE2 HIS A 194 -26.036 24.823 -40.740 1.00 43.62 N \\\\nATOM 1567 N GLN A 195 -30.471 23.707 -35.955 1.00 34.38 N \\\\nATOM 1568 CA GLN A 195 -31.841 23.260 -35.637 1.00 34.38 C \\\\nATOM 1569 C GLN A 195 -32.716 23.226 -36.901 1.00 34.38 C \\\\nATOM 1570 CB GLN A 195 -32.523 24.269 -34.690 1.00 34.38 C \\\\nATOM 1571 O GLN A 195 -32.548 24.103 -37.742 1.00 34.38 O \\\\nATOM 1572 CG GLN A 195 -32.220 24.116 -33.198 1.00 34.38 C \\\\nATOM 1573 CD GLN A 195 -32.992 25.136 -32.354 1.00 34.38 C \\\\nATOM 1574 NE2 GLN A 195 -32.890 25.070 -31.046 1.00 34.38 N \\\\nATOM 1575 OE1 GLN A 195 -33.706 26.001 -32.834 1.00 34.38 O \\\\nATOM 1576 N MET A 196 -33.689 22.298 -36.971 1.00 43.58 N \\\\nATOM 1577 CA MET A 196 -34.997 22.344 -37.686 1.00 43.58 C \\\\nATOM 1578 C MET A 196 -35.638 20.930 -37.660 1.00 43.58 C \\\\nATOM 1579 CB MET A 196 -34.835 22.770 -39.167 1.00 43.58 C \\\\nATOM 1580 O MET A 196 -34.898 19.954 -37.655 1.00 43.58 O \\\\nATOM 1581 CG MET A 196 -34.842 24.298 -39.367 1.00 43.58 C \\\\nATOM 1582 SD MET A 196 -36.152 24.997 -40.407 1.00 43.58 S \\\\nATOM 1583 CE MET A 196 -35.694 26.747 -40.262 1.00 43.58 C \\\\nATOM 1584 N ASN A 197 -36.958 20.690 -37.705 1.00 41.11 N \\\\nATOM 1585 CA ASN A 197 -38.153 21.466 -37.322 1.00 41.11 C \\\\nATOM 1586 C ASN A 197 -39.364 20.485 -37.186 1.00 41.11 C \\\\nATOM 1587 CB ASN A 197 -38.439 22.571 -38.361 1.00 41.11 C \\\\nATOM 1588 O ASN A 197 -39.254 19.313 -37.540 1.00 41.11 O \\\\nATOM 1589 CG ASN A 197 -39.298 23.710 -37.834 1.00 41.11 C \\\\nATOM 1590 ND2 ASN A 197 -39.465 24.753 -38.609 1.00 41.11 N \\\\nATOM 1591 OD1 ASN A 197 -39.813 23.690 -36.728 1.00 41.11 O \\\\nATOM 1592 N HIS A 198 -40.511 20.944 -36.673 1.00 40.12 N \\\\nATOM 1593 CA HIS A 198 -41.731 20.157 -36.393 1.00 40.12 C \\\\nATOM 1594 C HIS A 198 -42.478 19.583 -37.619 1.00 40.12 C \\\\nATOM 1595 CB HIS A 198 -42.733 21.089 -35.691 1.00 40.12 C \\\\nATOM 1596 O HIS A 198 -42.436 20.176 -38.696 1.00 40.12 O \\\\nATOM 1597 CG HIS A 198 -42.362 21.505 -34.298 1.00 40.12 C \\\\nATOM 1598 CD2 HIS A 198 -41.690 22.640 -33.929 1.00 40.12 C \\\\nATOM 1599 ND1 HIS A 198 -42.742 20.860 -33.143 1.00 40.12 N \\\\nATOM 1600 CE1 HIS A 198 -42.304 21.586 -32.102 1.00 40.12 C \\\\nATOM 1601 NE2 HIS A 198 -41.659 22.679 -32.531 1.00 40.12 N \\\\nATOM 1602 N SER A 199 -43.319 18.552 -37.397 1.00 44.95 N \\\\nATOM 1603 CA SER A 199 -44.767 18.530 -37.752 1.00 44.95 C \\\\nATOM 1604 C SER A 199 -45.504 17.297 -37.184 1.00 44.95 C \\\\nATOM 1605 CB SER A 199 -45.013 18.600 -39.264 1.00 44.95 C \\\\nATOM 1606 O SER A 199 -44.880 16.278 -36.905 1.00 44.95 O \\\\nATOM 1607 OG SER A 199 -44.858 19.940 -39.677 1.00 44.95 O \\\\nATOM 1608 N MET A 200 -46.827 17.399 -36.996 1.00 45.79 N \\\\nATOM 1609 CA MET A 200 -47.737 16.340 -36.510 1.00 45.79 C \\\\nATOM 1610 C MET A 200 -48.777 15.996 -37.591 1.00 45.79 C \\\\nATOM 1611 CB MET A 200 -48.544 16.849 -35.293 1.00 45.79 C \\\\nATOM 1612 O MET A 200 -49.139 16.913 -38.320 1.00 45.79 O \\\\nATOM 1613 CG MET A 200 -47.745 17.422 -34.119 1.00 45.79 C \\\\nATOM 1614 SD MET A 200 -48.821 18.013 -32.777 1.00 45.79 S \\\\nATOM 1615 CE MET A 200 -47.596 18.699 -31.636 1.00 45.79 C \\\\nATOM 1616 N ASP A 201 -49.331 14.771 -37.623 1.00 46.67 N \\\\nATOM 1617 CA ASP A 201 -50.800 14.576 -37.689 1.00 46.67 C \\\\nATOM 1618 C ASP A 201 -51.266 13.129 -37.369 1.00 46.67 C \\\\nATOM 1619 CB ASP A 201 -51.455 15.079 -38.999 1.00 46.67 C \\\\nATOM 1620 O ASP A 201 -50.450 12.229 -37.159 1.00 46.67 O \\\\nATOM 1621 CG ASP A 201 -52.680 15.954 -38.674 1.00 46.67 C \\\\nATOM 1622 OD1 ASP A 201 -53.380 15.616 -37.687 1.00 46.67 O \\\\nATOM 1623 OD2 ASP A 201 -52.926 16.935 -39.408 1.00 46.67 O \\\\nATOM 1624 N ALA A 202 -52.585 12.935 -37.251 1.00 43.71 N \\\\nATOM 1625 CA ALA A 202 -53.251 11.820 -36.563 1.00 43.71 C \\\\nATOM 1626 C ALA A 202 -53.674 10.601 -37.424 1.00 43.71 C \\\\nATOM 1627 CB ALA A 202 -54.477 12.426 -35.864 1.00 43.71 C \\\\nATOM 1628 O ALA A 202 -53.850 10.694 -38.636 1.00 43.71 O \\\\nATOM 1629 N GLY A 203 -53.959 9.462 -36.762 1.00 40.70 N \\\\nATOM 1630 CA GLY A 203 -54.671 8.322 -37.373 1.00 40.70 C \\\\nATOM 1631 C GLY A 203 -54.584 6.979 -36.622 1.00 40.70 C \\\\nATOM 1632 O GLY A 203 -53.621 6.241 -36.779 1.00 40.70 O \\\\nATOM 1633 N SER A 204 -55.635 6.626 -35.875 1.00 42.76 N \\\\nATOM 1634 CA SER A 204 -55.953 5.263 -35.375 1.00 42.76 C \\\\nATOM 1635 C SER A 204 -57.215 4.749 -36.114 1.00 42.76 C \\\\nATOM 1636 CB SER A 204 -56.175 5.346 -33.854 1.00 42.76 C \\\\nATOM 1637 O SER A 204 -57.909 5.613 -36.658 1.00 42.76 O \\\\nATOM 1638 OG SER A 204 -54.953 5.182 -33.165 1.00 42.76 O \\\\nATOM 1639 N PRO A 205 -57.600 3.440 -36.129 1.00 46.18 N \\\\nATOM 1640 CA PRO A 205 -57.311 2.419 -35.103 1.00 46.18 C \\\\nATOM 1641 C PRO A 205 -57.072 0.946 -35.563 1.00 46.18 C \\\\nATOM 1642 CB PRO A 205 -58.634 2.448 -34.321 1.00 46.18 C \\\\nATOM 1643 O PRO A 205 -57.305 0.567 -36.703 1.00 46.18 O \\\\nATOM 1644 CG PRO A 205 -59.689 2.523 -35.436 1.00 46.18 C \\\\nATOM 1645 CD PRO A 205 -58.931 3.098 -36.637 1.00 46.18 C \\\\nATOM 1646 N ASN A 206 -56.707 0.107 -34.579 1.00 39.37 N \\\\nATOM 1647 CA ASN A 206 -57.019 -1.327 -34.383 1.00 39.37 C \\\\nATOM 1648 C ASN A 206 -57.092 -2.311 -35.573 1.00 39.37 C \\\\nATOM 1649 CB ASN A 206 -58.360 -1.430 -33.622 1.00 39.37 C \\\\nATOM 1650 O ASN A 206 -58.089 -2.336 -36.285 1.00 39.37 O \\\\nATOM 1651 CG ASN A 206 -58.338 -0.871 -32.217 1.00 39.37 C \\\\nATOM 1652 ND2 ASN A 206 -59.478 -0.807 -31.571 1.00 39.37 N \\\\nATOM 1653 OD1 ASN A 206 -57.317 -0.484 -31.679 1.00 39.37 O \\\\nATOM 1654 N LEU A 207 -56.196 -3.312 -35.564 1.00 44.78 N \\\\nATOM 1655 CA LEU A 207 -56.487 -4.720 -35.904 1.00 44.78 C \\\\nATOM 1656 C LEU A 207 -55.433 -5.648 -35.248 1.00 44.78 C \\\\nATOM 1657 CB LEU A 207 -56.518 -4.928 -37.441 1.00 44.78 C \\\\nATOM 1658 O LEU A 207 -54.266 -5.622 -35.625 1.00 44.78 O \\\\nATOM 1659 CG LEU A 207 -57.917 -4.971 -38.099 1.00 44.78 C \\\\nATOM 1660 CD1 LEU A 207 -57.771 -4.972 -39.620 1.00 44.78 C \\\\nATOM 1661 CD2 LEU A 207 -58.716 -6.216 -37.699 1.00 44.78 C \\\\nATOM 1662 N SER A 208 -55.842 -6.478 -34.284 1.00 40.73 N \\\\nATOM 1663 CA SER A 208 -55.055 -7.621 -33.762 1.00 40.73 C \\\\nATOM 1664 C SER A 208 -55.432 -8.888 -34.557 1.00 40.73 C \\\\nATOM 1665 CB SER A 208 -55.324 -7.826 -32.261 1.00 40.73 C \\\\nATOM 1666 O SER A 208 -56.579 -8.945 -35.011 1.00 40.73 O \\\\nATOM 1667 OG SER A 208 -55.350 -6.605 -31.544 1.00 40.73 O \\\\nATOM 1668 N PRO A 209 -54.570 -9.926 -34.702 1.00 44.83 N \\\\nATOM 1669 CA PRO A 209 -54.400 -10.888 -33.596 1.00 44.83 C \\\\nATOM 1670 C PRO A 209 -53.067 -11.690 -33.521 1.00 44.83 C \\\\nATOM 1671 CB PRO A 209 -55.548 -11.872 -33.862 1.00 44.83 C \\\\nATOM 1672 O PRO A 209 -52.260 -11.716 -34.441 1.00 44.83 O \\\\nATOM 1673 CG PRO A 209 -55.517 -12.030 -35.384 1.00 44.83 C \\\\nATOM 1674 CD PRO A 209 -54.779 -10.779 -35.876 1.00 44.83 C \\\\nATOM 1675 N ASN A 210 -52.975 -12.466 -32.431 1.00 41.10 N \\\\nATOM 1676 CA ASN A 210 -52.140 -13.654 -32.163 1.00 41.10 C \\\\nATOM 1677 C ASN A 210 -50.635 -13.492 -31.825 1.00 41.10 C \\\\nATOM 1678 CB ASN A 210 -52.397 -14.760 -33.202 1.00 41.10 C \\\\nATOM 1679 O ASN A 210 -49.853 -13.017 -32.644 1.00 41.10 O \\\\nATOM 1680 CG ASN A 210 -53.775 -15.385 -33.076 1.00 41.10 C \\\\nATOM 1681 ND2 ASN A 210 -54.098 -16.329 -33.926 1.00 41.10 N \\\\nATOM 1682 OD1 ASN A 210 -54.574 -15.061 -32.210 1.00 41.10 O \\\\nATOM 1683 N PRO A 211 -50.195 -13.989 -30.644 1.00 40.72 N \\\\nATOM 1684 CA PRO A 211 -48.784 -14.075 -30.279 1.00 40.72 C \\\\nATOM 1685 C PRO A 211 -48.138 -15.368 -30.802 1.00 40.72 C \\\\nATOM 1686 CB PRO A 211 -48.777 -14.031 -28.748 1.00 40.72 C \\\\nATOM 1687 O PRO A 211 -48.693 -16.457 -30.648 1.00 40.72 O \\\\nATOM 1688 CG PRO A 211 -50.056 -14.780 -28.371 1.00 40.72 C \\\\nATOM 1689 CD PRO A 211 -51.010 -14.460 -29.524 1.00 40.72 C \\\\nATOM 1690 N MET A 212 -46.921 -15.265 -31.338 1.00 42.15 N \\\\nATOM 1691 CA MET A 212 -46.016 -16.412 -31.467 1.00 42.15 C \\\\nATOM 1692 C MET A 212 -45.120 -16.483 -30.229 1.00 42.15 C \\\\nATOM 1693 CB MET A 212 -45.197 -16.341 -32.766 1.00 42.15 C \\\\nATOM 1694 O MET A 212 -44.534 -15.481 -29.822 1.00 42.15 O \\\\nATOM 1695 CG MET A 212 -46.095 -16.597 -33.984 1.00 42.15 C \\\\nATOM 1696 SD MET A 212 -45.256 -16.690 -35.591 1.00 42.15 S \\\\nATOM 1697 CE MET A 212 -44.234 -18.174 -35.381 1.00 42.15 C \\\\nATOM 1698 N SER A 213 -45.035 -17.666 -29.621 1.00 39.51 N \\\\nATOM 1699 CA SER A 213 -44.201 -17.926 -28.446 1.00 39.51 C \\\\nATOM 1700 C SER A 213 -42.723 -17.623 -28.732 1.00 39.51 C \\\\nATOM 1701 CB SER A 213 -44.315 -19.400 -28.044 1.00 39.51 C \\\\nATOM 1702 O SER A 213 -42.234 -18.034 -29.788 1.00 39.51 O \\\\nATOM 1703 OG SER A 213 -45.673 -19.802 -27.981 1.00 39.51 O \\\\nATOM 1704 N PRO A 214 -41.972 -16.991 -27.810 1.00 42.72 N \\\\nATOM 1705 CA PRO A 214 -40.527 -16.881 -27.955 1.00 42.72 C \\\\nATOM 1706 C PRO A 214 -39.909 -18.278 -27.898 1.00 42.72 C \\\\nATOM 1707 CB PRO A 214 -40.030 -16.000 -26.800 1.00 42.72 C \\\\nATOM 1708 O PRO A 214 -40.210 -19.057 -26.990 1.00 42.72 O \\\\nATOM 1709 CG PRO A 214 -41.299 -15.382 -26.214 1.00 42.72 C \\\\nATOM 1710 CD PRO A 214 -42.392 -16.393 -26.555 1.00 42.72 C \\\\nATOM 1711 N ALA A 215 -39.018 -18.593 -28.837 1.00 38.54 N \\\\nATOM 1712 CA ALA A 215 -38.164 -19.761 -28.699 1.00 38.54 C \\\\nATOM 1713 C ALA A 215 -37.263 -19.558 -27.471 1.00 38.54 C \\\\nATOM 1714 CB ALA A 215 -37.366 -19.964 -29.993 1.00 38.54 C \\\\nATOM 1715 O ALA A 215 -36.411 -18.668 -27.457 1.00 38.54 O \\\\nATOM 1716 N HIS A 216 -37.455 -20.375 -26.433 1.00 40.42 N \\\\nATOM 1717 CA HIS A 216 -36.520 -20.447 -25.316 1.00 40.42 C \\\\nATOM 1718 C HIS A 216 -35.209 -21.071 -25.806 1.00 40.42 C \\\\nATOM 1719 CB HIS A 216 -37.123 -21.222 -24.129 1.00 40.42 C \\\\nATOM 1720 O HIS A 216 -35.005 -22.281 -25.704 1.00 40.42 O \\\\nATOM 1721 CG HIS A 216 -37.967 -20.379 -23.206 1.00 40.42 C \\\\nATOM 1722 CD2 HIS A 216 -39.316 -20.482 -22.997 1.00 40.42 C \\\\nATOM 1723 ND1 HIS A 216 -37.497 -19.419 -22.338 1.00 40.42 N \\\\nATOM 1724 CE1 HIS A 216 -38.538 -18.952 -21.629 1.00 40.42 C \\\\nATOM 1725 NE2 HIS A 216 -39.670 -19.572 -21.994 1.00 40.42 N \\\\nATOM 1726 N ASN A 217 -34.301 -20.230 -26.305 1.00 45.94 N \\\\nATOM 1727 CA ASN A 217 -32.886 -20.566 -26.348 1.00 45.94 C \\\\nATOM 1728 C ASN A 217 -32.417 -20.746 -24.900 1.00 45.94 C \\\\nATOM 1729 CB ASN A 217 -32.085 -19.479 -27.098 1.00 45.94 C \\\\nATOM 1730 O ASN A 217 -32.070 -19.777 -24.224 1.00 45.94 O \\\\nATOM 1731 CG ASN A 217 -32.078 -19.656 -28.607 1.00 45.94 C \\\\nATOM 1732 ND2 ASN A 217 -31.390 -18.796 -29.321 1.00 45.94 N \\\\nATOM 1733 OD1 ASN A 217 -32.661 -20.566 -29.167 1.00 45.94 O \\\\nATOM 1734 N ASN A 218 -32.422 -21.996 -24.430 1.00 48.29 N \\\\nATOM 1735 CA ASN A 218 -31.732 -22.420 -23.215 1.00 48.29 C \\\\nATOM 1736 C ASN A 218 -30.218 -22.322 -23.454 1.00 48.29 C \\\\nATOM 1737 CB ASN A 218 -32.196 -23.836 -22.795 1.00 48.29 C \\\\nATOM 1738 O ASN A 218 -29.524 -23.321 -23.636 1.00 48.29 O \\\\nATOM 1739 CG ASN A 218 -33.261 -23.865 -21.712 1.00 48.29 C \\\\nATOM 1740 ND2 ASN A 218 -33.691 -25.044 -21.328 1.00 48.29 N \\\\nATOM 1741 OD1 ASN A 218 -33.708 -22.868 -21.174 1.00 48.29 O \\\\nATOM 1742 N LEU A 219 -29.712 -21.090 -23.470 1.00 60.32 N \\\\nATOM 1743 CA LEU A 219 -28.303 -20.815 -23.246 1.00 60.32 C \\\\nATOM 1744 C LEU A 219 -27.998 -21.275 -21.819 1.00 60.32 C \\\\nATOM 1745 CB LEU A 219 -28.035 -19.313 -23.455 1.00 60.32 C \\\\nATOM 1746 O LEU A 219 -28.474 -20.677 -20.854 1.00 60.32 O \\\\nATOM 1747 CG LEU A 219 -28.042 -18.894 -24.937 1.00 60.32 C \\\\nATOM 1748 CD1 LEU A 219 -28.221 -17.382 -25.062 1.00 60.32 C \\\\nATOM 1749 CD2 LEU A 219 -26.732 -19.278 -25.630 1.00 60.32 C \\\\nATOM 1750 N ASP A 220 -27.247 -22.368 -21.699 1.00 74.45 N \\\\nATOM 1751 CA ASP A 220 -26.793 -22.909 -20.419 1.00 74.45 C \\\\nATOM 1752 C ASP A 220 -25.707 -21.976 -19.855 1.00 74.45 C \\\\nATOM 1753 CB ASP A 220 -26.366 -24.375 -20.612 1.00 74.45 C \\\\nATOM 1754 O ASP A 220 -24.509 -22.128 -20.106 1.00 74.45 O \\\\nATOM 1755 CG ASP A 220 -26.139 -25.137 -19.300 1.00 74.45 C \\\\nATOM 1756 OD1 ASP A 220 -26.610 -24.684 -18.235 1.00 74.45 O \\\\nATOM 1757 OD2 ASP A 220 -25.480 -26.202 -19.357 1.00 74.45 O \\\\nATOM 1758 N LEU A 221 -26.177 -20.912 -19.198 1.00 81.69 N \\\\nATOM 1759 CA LEU A 221 -25.384 -19.817 -18.652 1.00 81.69 C \\\\nATOM 1760 C LEU A 221 -24.868 -20.190 -17.261 1.00 81.69 C \\\\nATOM 1761 CB LEU A 221 -26.244 -18.539 -18.591 1.00 81.69 C \\\\nATOM 1762 O LEU A 221 -25.641 -20.307 -16.308 1.00 81.69 O \\\\nATOM 1763 CG LEU A 221 -26.532 -17.876 -19.951 1.00 81.69 C \\\\nATOM 1764 CD1 LEU A 221 -27.616 -16.809 -19.796 1.00 81.69 C \\\\nATOM 1765 CD2 LEU A 221 -25.300 -17.189 -20.537 1.00 81.69 C \\\\nATOM 1766 N GLN A 222 -23.551 -20.314 -17.121 1.00 85.05 N \\\\nATOM 1767 CA GLN A 222 -22.922 -20.623 -15.844 1.00 85.05 C \\\\nATOM 1768 C GLN A 222 -22.578 -19.327 -15.078 1.00 85.05 C \\\\nATOM 1769 CB GLN A 222 -21.723 -21.549 -16.088 1.00 85.05 C \\\\nATOM 1770 O GLN A 222 -21.875 -18.469 -15.616 1.00 85.05 O \\\\nATOM 1771 CG GLN A 222 -21.146 -22.068 -14.764 1.00 85.05 C \\\\nATOM 1772 CD GLN A 222 -20.201 -23.256 -14.935 1.00 85.05 C \\\\nATOM 1773 NE2 GLN A 222 -19.224 -23.405 -14.071 1.00 85.05 N \\\\nATOM 1774 OE1 GLN A 222 -20.361 -24.133 -15.776 1.00 85.05 O \\\\nATOM 1775 N PRO A 223 -23.056 -19.142 -13.830 1.00 90.37 N \\\\nATOM 1776 CA PRO A 223 -22.756 -17.950 -13.042 1.00 90.37 C \\\\nATOM 1777 C PRO A 223 -21.366 -18.020 -12.394 1.00 90.37 C \\\\nATOM 1778 CB PRO A 223 -23.877 -17.858 -12.003 1.00 90.37 C \\\\nATOM 1779 O PRO A 223 -21.036 -18.970 -11.681 1.00 90.37 O \\\\nATOM 1780 CG PRO A 223 -24.265 -19.319 -11.776 1.00 90.37 C \\\\nATOM 1781 CD PRO A 223 -24.053 -19.958 -13.149 1.00 90.37 C \\\\nATOM 1782 N VAL A 224 -20.577 -16.961 -12.571 1.00 90.45 N \\\\nATOM 1783 CA VAL A 224 -19.236 -16.791 -12.000 1.00 90.45 C \\\\nATOM 1784 C VAL A 224 -19.241 -15.674 -10.963 1.00 90.45 C \\\\nATOM 1785 CB VAL A 224 -18.185 -16.520 -13.094 1.00 90.45 C \\\\nATOM 1786 O VAL A 224 -19.332 -14.489 -11.293 1.00 90.45 O \\\\nATOM 1787 CG1 VAL A 224 -16.787 -16.560 -12.468 1.00 90.45 C \\\\nATOM 1788 CG2 VAL A 224 -18.242 -17.587 -14.185 1.00 90.45 C \\\\nATOM 1789 N THR A 225 -19.119 -16.047 -9.690 1.00 90.96 N \\\\nATOM 1790 CA THR A 225 -19.107 -15.113 -8.558 1.00 90.96 C \\\\nATOM 1791 C THR A 225 -17.708 -14.574 -8.245 1.00 90.96 C \\\\nATOM 1792 CB THR A 225 -19.718 -15.750 -7.299 1.00 90.96 C \\\\nATOM 1793 O THR A 225 -16.707 -15.306 -8.235 1.00 90.96 O \\\\nATOM 1794 CG2 THR A 225 -21.223 -15.974 -7.443 1.00 90.96 C \\\\nATOM 1795 OG1 THR A 225 -19.143 -17.012 -7.043 1.00 90.96 O \\\\nATOM 1796 N TYR A 226 -17.656 -13.279 -7.920 1.00 91.36 N \\\\nATOM 1797 CA TYR A 226 -16.485 -12.645 -7.317 1.00 91.36 C \\\\nATOM 1798 C TYR A 226 -16.177 -13.268 -5.947 1.00 91.36 C \\\\nATOM 1799 CB TYR A 226 -16.729 -11.137 -7.179 1.00 91.36 C \\\\nATOM 1800 O TYR A 226 -17.081 -13.659 -5.205 1.00 91.36 O \\\\nATOM 1801 CG TYR A 226 -15.526 -10.357 -6.675 1.00 91.36 C \\\\nATOM 1802 CD1 TYR A 226 -15.400 -10.011 -5.314 1.00 91.36 C \\\\nATOM 1803 CD2 TYR A 226 -14.536 -9.953 -7.586 1.00 91.36 C \\\\nATOM 1804 CE1 TYR A 226 -14.290 -9.258 -4.874 1.00 91.36 C \\\\nATOM 1805 CE2 TYR A 226 -13.447 -9.174 -7.158 1.00 91.36 C \\\\nATOM 1806 OH TYR A 226 -12.242 -8.086 -5.408 1.00 91.36 O \\\\nATOM 1807 CZ TYR A 226 -13.310 -8.831 -5.798 1.00 91.36 C \\\\nATOM 1808 N CYS A 227 -14.896 -13.343 -5.592 1.00 88.04 N \\\\nATOM 1809 CA CYS A 227 -14.446 -13.685 -4.245 1.00 88.04 C \\\\nATOM 1810 C CYS A 227 -13.320 -12.729 -3.857 1.00 88.04 C \\\\nATOM 1811 CB CYS A 227 -13.971 -15.144 -4.176 1.00 88.04 C \\\\nATOM 1812 O CYS A 227 -12.443 -12.461 -4.673 1.00 88.04 O \\\\nATOM 1813 SG CYS A 227 -15.324 -16.288 -4.590 1.00 88.04 S \\\\nATOM 1814 N GLU A 228 -13.341 -12.228 -2.624 1.00 87.08 N \\\\nATOM 1815 CA GLU A 228 -12.293 -11.333 -2.136 1.00 87.08 C \\\\nATOM 1816 C GLU A 228 -11.044 -12.157 -1.749 1.00 87.08 C \\\\nATOM 1817 CB GLU A 228 -12.835 -10.504 -0.959 1.00 87.08 C \\\\nATOM 1818 O GLU A 228 -11.162 -13.089 -0.945 1.00 87.08 O \\\\nATOM 1819 CG GLU A 228 -12.081 -9.184 -0.760 1.00 87.08 C \\\\nATOM 1820 CD GLU A 228 -12.445 -8.166 -1.847 1.00 87.08 C \\\\nATOM 1821 OE1 GLU A 228 -11.724 -8.084 -2.862 1.00 87.08 O \\\\nATOM 1822 OE2 GLU A 228 -13.462 -7.454 -1.705 1.00 87.08 O \\\\nATOM 1823 N PRO A 229 -9.856 -11.871 -2.307 1.00 91.38 N \\\\nATOM 1824 CA PRO A 229 -8.630 -12.602 -1.993 1.00 91.38 C \\\\nATOM 1825 C PRO A 229 -8.013 -12.151 -0.659 1.00 91.38 C \\\\nATOM 1826 CB PRO A 229 -7.696 -12.322 -3.172 1.00 91.38 C \\\\nATOM 1827 O PRO A 229 -8.198 -11.022 -0.213 1.00 91.38 O \\\\nATOM 1828 CG PRO A 229 -8.092 -10.899 -3.553 1.00 91.38 C \\\\nATOM 1829 CD PRO A 229 -9.602 -10.891 -3.353 1.00 91.38 C \\\\nATOM 1830 N ALA A 230 -7.183 -13.009 -0.054 1.00 90.34 N \\\\nATOM 1831 CA ALA A 230 -6.465 -12.698 1.192 1.00 90.34 C \\\\nATOM 1832 C ALA A 230 -5.456 -11.533 1.066 1.00 90.34 C \\\\nATOM 1833 CB ALA A 230 -5.759 -13.977 1.660 1.00 90.34 C \\\\nATOM 1834 O ALA A 230 -5.130 -10.879 2.056 1.00 90.34 O \\\\nATOM 1835 N PHE A 231 -4.973 -11.272 -0.152 1.00 94.61 N \\\\nATOM 1836 CA PHE A 231 -4.199 -10.086 -0.509 1.00 94.61 C \\\\nATOM 1837 C PHE A 231 -4.930 -9.383 -1.649 1.00 94.61 C \\\\nATOM 1838 CB PHE A 231 -2.775 -10.474 -0.935 1.00 94.61 C \\\\nATOM 1839 O PHE A 231 -5.084 -9.979 -2.715 1.00 94.61 O \\\\nATOM 1840 CG PHE A 231 -1.985 -11.239 0.107 1.00 94.61 C \\\\nATOM 1841 CD1 PHE A 231 -1.300 -10.545 1.119 1.00 94.61 C \\\\nATOM 1842 CD2 PHE A 231 -1.917 -12.644 0.056 1.00 94.61 C \\\\nATOM 1843 CE1 PHE A 231 -0.547 -11.247 2.076 1.00 94.61 C \\\\nATOM 1844 CE2 PHE A 231 -1.170 -13.349 1.017 1.00 94.61 C \\\\nATOM 1845 CZ PHE A 231 -0.486 -12.650 2.027 1.00 94.61 C \\\\nATOM 1846 N TRP A 232 -5.376 -8.142 -1.456 1.00 95.43 N \\\\nATOM 1847 CA TRP A 232 -6.197 -7.431 -2.445 1.00 95.43 C \\\\nATOM 1848 C TRP A 232 -5.375 -6.933 -3.644 1.00 95.43 C \\\\nATOM 1849 CB TRP A 232 -6.971 -6.306 -1.752 1.00 95.43 C \\\\nATOM 1850 O TRP A 232 -5.883 -6.886 -4.766 1.00 95.43 O \\\\nATOM 1851 CG TRP A 232 -6.131 -5.200 -1.196 1.00 95.43 C \\\\nATOM 1852 CD1 TRP A 232 -5.652 -5.120 0.065 1.00 95.43 C \\\\nATOM 1853 CD2 TRP A 232 -5.664 -3.998 -1.878 1.00 95.43 C \\\\nATOM 1854 CE2 TRP A 232 -4.882 -3.233 -0.963 1.00 95.43 C \\\\nATOM 1855 CE3 TRP A 232 -5.831 -3.479 -3.180 1.00 95.43 C \\\\nATOM 1856 NE1 TRP A 232 -4.917 -3.961 0.205 1.00 95.43 N \\\\nATOM 1857 CH2 TRP A 232 -4.469 -1.529 -2.630 1.00 95.43 C \\\\nATOM 1858 CZ2 TRP A 232 -4.287 -2.015 -1.323 1.00 95.43 C \\\\nATOM 1859 CZ3 TRP A 232 -5.238 -2.259 -3.554 1.00 95.43 C \\\\nATOM 1860 N CYS A 233 -4.085 -6.643 -3.443 1.00 97.66 N \\\\nATOM 1861 CA CYS A 233 -3.142 -6.409 -4.533 1.00 97.66 C \\\\nATOM 1862 C CYS A 233 -1.744 -6.980 -4.268 1.00 97.66 C \\\\nATOM 1863 CB CYS A 233 -3.097 -4.915 -4.904 1.00 97.66 C \\\\nATOM 1864 O CYS A 233 -1.371 -7.311 -3.137 1.00 97.66 O \\\\nATOM 1865 SG CYS A 233 -2.220 -3.908 -3.672 1.00 97.66 S \\\\nATOM 1866 N SER A 234 -0.963 -7.073 -5.340 1.00 98.00 N \\\\nATOM 1867 CA SER A 234 0.484 -7.274 -5.297 1.00 98.00 C \\\\nATOM 1868 C SER A 234 1.196 -6.126 -6.021 1.00 98.00 C \\\\nATOM 1869 CB SER A 234 0.855 -8.653 -5.846 1.00 98.00 C \\\\nATOM 1870 O SER A 234 0.656 -5.569 -6.978 1.00 98.00 O \\\\nATOM 1871 OG SER A 234 0.561 -8.773 -7.220 1.00 98.00 O \\\\nATOM 1872 N ILE A 235 2.374 -5.727 -5.534 1.00 98.48 N \\\\nATOM 1873 CA ILE A 235 3.124 -4.561 -6.018 1.00 98.48 C \\\\nATOM 1874 C ILE A 235 4.563 -4.957 -6.337 1.00 98.48 C \\\\nATOM 1875 CB ILE A 235 3.083 -3.380 -5.017 1.00 98.48 C \\\\nATOM 1876 O ILE A 235 5.286 -5.443 -5.467 1.00 98.48 O \\\\nATOM 1877 CG1 ILE A 235 1.628 -3.071 -4.597 1.00 98.48 C \\\\nATOM 1878 CG2 ILE A 235 3.764 -2.146 -5.646 1.00 98.48 C \\\\nATOM 1879 CD1 ILE A 235 1.453 -1.811 -3.745 1.00 98.48 C \\\\nATOM 1880 N SER A 236 5.002 -4.695 -7.566 1.00 98.56 N \\\\nATOM 1881 CA SER A 236 6.394 -4.879 -7.998 1.00 98.56 C \\\\nATOM 1882 C SER A 236 7.045 -3.523 -8.282 1.00 98.56 C \\\\nATOM 1883 CB SER A 236 6.453 -5.806 -9.215 1.00 98.56 C \\\\nATOM 1884 O SER A 236 6.434 -2.671 -8.924 1.00 98.56 O \\\\nATOM 1885 OG SER A 236 5.926 -7.081 -8.879 1.00 98.56 O \\\\nATOM 1886 N TYR A 237 8.271 -3.307 -7.796 1.00 98.69 N \\\\nATOM 1887 CA TYR A 237 9.032 -2.067 -7.999 1.00 98.69 C \\\\nATOM 1888 C TYR A 237 10.047 -2.195 -9.137 1.00 98.69 C \\\\nATOM 1889 CB TYR A 237 9.692 -1.633 -6.680 1.00 98.69 C \\\\nATOM 1890 O TYR A 237 10.666 -3.245 -9.328 1.00 98.69 O \\\\nATOM 1891 CG TYR A 237 10.637 -0.444 -6.789 1.00 98.69 C \\\\nATOM 1892 CD1 TYR A 237 12.003 -0.597 -6.486 1.00 98.69 C \\\\nATOM 1893 CD2 TYR A 237 10.156 0.816 -7.191 1.00 98.69 C \\\\nATOM 1894 CE1 TYR A 237 12.878 0.503 -6.562 1.00 98.69 C \\\\nATOM 1895 CE2 TYR A 237 11.029 1.915 -7.294 1.00 98.69 C \\\\nATOM 1896 OH TYR A 237 13.219 2.844 -6.988 1.00 98.69 O \\\\nATOM 1897 CZ TYR A 237 12.391 1.765 -6.962 1.00 98.69 C \\\\nATOM 1898 N TYR A 238 10.217 -1.103 -9.881 1.00 98.77 N \\\\nATOM 1899 CA TYR A 238 11.071 -1.011 -11.053 1.00 98.77 C \\\\nATOM 1900 C TYR A 238 11.893 0.282 -11.053 1.00 98.77 C \\\\nATOM 1901 CB TYR A 238 10.215 -1.095 -12.322 1.00 98.77 C \\\\nATOM 1902 O TYR A 238 11.424 1.369 -10.693 1.00 98.77 O \\\\nATOM 1903 CG TYR A 238 9.557 -2.438 -12.582 1.00 98.77 C \\\\nATOM 1904 CD1 TYR A 238 10.127 -3.335 -13.507 1.00 98.77 C \\\\nATOM 1905 CD2 TYR A 238 8.351 -2.771 -11.935 1.00 98.77 C \\\\nATOM 1906 CE1 TYR A 238 9.513 -4.577 -13.760 1.00 98.77 C \\\\nATOM 1907 CE2 TYR A 238 7.751 -4.023 -12.163 1.00 98.77 C \\\\nATOM 1908 OH TYR A 238 7.774 -6.155 -13.249 1.00 98.77 O \\\\nATOM 1909 CZ TYR A 238 8.338 -4.934 -13.063 1.00 98.77 C \\\\nATOM 1910 N GLU A 239 13.128 0.159 -11.527 1.00 98.62 N \\\\nATOM 1911 CA GLU A 239 14.019 1.264 -11.862 1.00 98.62 C \\\\nATOM 1912 C GLU A 239 14.323 1.165 -13.362 1.00 98.62 C \\\\nATOM 1913 CB GLU A 239 15.284 1.228 -10.979 1.00 98.62 C \\\\nATOM 1914 O GLU A 239 14.958 0.211 -13.810 1.00 98.62 O \\\\nATOM 1915 CG GLU A 239 14.940 1.495 -9.500 1.00 98.62 C \\\\nATOM 1916 CD GLU A 239 16.132 1.483 -8.527 1.00 98.62 C \\\\nATOM 1917 OE1 GLU A 239 15.922 1.704 -7.311 1.00 98.62 O \\\\nATOM 1918 OE2 GLU A 239 17.306 1.282 -8.916 1.00 98.62 O \\\\nATOM 1919 N LEU A 240 13.834 2.127 -14.153 1.00 98.06 N \\\\nATOM 1920 CA LEU A 240 13.823 2.051 -15.621 1.00 98.06 C \\\\nATOM 1921 C LEU A 240 13.079 0.792 -16.117 1.00 98.06 C \\\\nATOM 1922 CB LEU A 240 15.248 2.233 -16.192 1.00 98.06 C \\\\nATOM 1923 O LEU A 240 11.916 0.600 -15.776 1.00 98.06 O \\\\nATOM 1924 CG LEU A 240 15.969 3.510 -15.728 1.00 98.06 C \\\\nATOM 1925 CD1 LEU A 240 17.434 3.448 -16.154 1.00 98.06 C \\\\nATOM 1926 CD2 LEU A 240 15.350 4.776 -16.327 1.00 98.06 C \\\\nATOM 1927 N ASN A 241 13.710 -0.073 -16.912 1.00 97.14 N \\\\nATOM 1928 CA ASN A 241 13.154 -1.360 -17.346 1.00 97.14 C \\\\nATOM 1929 C ASN A 241 13.502 -2.533 -16.405 1.00 97.14 C \\\\nATOM 1930 CB ASN A 241 13.596 -1.633 -18.797 1.00 97.14 C \\\\nATOM 1931 O ASN A 241 13.069 -3.658 -16.655 1.00 97.14 O \\\\nATOM 1932 CG ASN A 241 15.097 -1.813 -18.965 1.00 97.14 C \\\\nATOM 1933 ND2 ASN A 241 15.528 -2.374 -20.069 1.00 97.14 N \\\\nATOM 1934 OD1 ASN A 241 15.903 -1.420 -18.136 1.00 97.14 O \\\\nATOM 1935 N GLN A 242 14.276 -2.305 -15.340 1.00 97.90 N \\\\nATOM 1936 CA GLN A 242 14.739 -3.357 -14.439 1.00 97.90 C \\\\nATOM 1937 C GLN A 242 13.834 -3.473 -13.211 1.00 97.90 C \\\\nATOM 1938 CB GLN A 242 16.203 -3.092 -14.058 1.00 97.90 C \\\\nATOM 1939 O GLN A 242 13.608 -2.500 -12.494 1.00 97.90 O \\\\nATOM 1940 CG GLN A 242 16.783 -4.233 -13.207 1.00 97.90 C \\\\nATOM 1941 CD GLN A 242 18.248 -4.032 -12.846 1.00 97.90 C \\\\nATOM 1942 NE2 GLN A 242 18.831 -4.925 -12.081 1.00 97.90 N \\\\nATOM 1943 OE1 GLN A 242 18.908 -3.084 -13.238 1.00 97.90 O \\\\nATOM 1944 N ARG A 243 13.365 -4.690 -12.920 1.00 98.06 N \\\\nATOM 1945 CA ARG A 243 12.677 -5.004 -11.663 1.00 98.06 C \\\\nATOM 1946 C ARG A 243 13.668 -4.998 -10.495 1.00 98.06 C \\\\nATOM 1947 CB ARG A 243 11.953 -6.346 -11.809 1.00 98.06 C \\\\nATOM 1948 O ARG A 243 14.748 -5.576 -10.598 1.00 98.06 O \\\\nATOM 1949 CG ARG A 243 11.106 -6.643 -10.571 1.00 98.06 C \\\\nATOM 1950 CD ARG A 243 10.301 -7.925 -10.764 1.00 98.06 C \\\\nATOM 1951 NE ARG A 243 9.956 -8.477 -9.451 1.00 98.06 N \\\\nATOM 1952 NH1 ARG A 243 8.193 -9.836 -10.058 1.00 98.06 N \\\\nATOM 1953 NH2 ARG A 243 8.897 -9.730 -7.940 1.00 98.06 N \\\\nATOM 1954 CZ ARG A 243 9.014 -9.349 -9.171 1.00 98.06 C \\\\nATOM 1955 N VAL A 244 13.291 -4.378 -9.379 1.00 98.38 N \\\\nATOM 1956 CA VAL A 244 14.143 -4.200 -8.196 1.00 98.38 C \\\\nATOM 1957 C VAL A 244 13.391 -4.645 -6.941 1.00 98.38 C \\\\nATOM 1958 CB VAL A 244 14.626 -2.736 -8.101 1.00 98.38 C \\\\nATOM 1959 O VAL A 244 12.381 -4.055 -6.570 1.00 98.38 O \\\\nATOM 1960 CG1 VAL A 244 15.439 -2.476 -6.827 1.00 98.38 C \\\\nATOM 1961 CG2 VAL A 244 15.519 -2.366 -9.293 1.00 98.38 C \\\\nATOM 1962 N GLY A 245 13.918 -5.665 -6.260 1.00 96.94 N \\\\nATOM 1963 CA GLY A 245 13.327 -6.223 -5.041 1.00 96.94 C \\\\nATOM 1964 C GLY A 245 12.210 -7.251 -5.269 1.00 96.94 C \\\\nATOM 1965 O GLY A 245 11.853 -7.617 -6.394 1.00 96.94 O \\\\nATOM 1966 N GLU A 246 11.680 -7.746 -4.153 1.00 96.05 N \\\\nATOM 1967 CA GLU A 246 10.594 -8.728 -4.106 1.00 96.05 C \\\\nATOM 1968 C GLU A 246 9.227 -8.084 -4.399 1.00 96.05 C \\\\nATOM 1969 CB GLU A 246 10.600 -9.438 -2.742 1.00 96.05 C \\\\nATOM 1970 O GLU A 246 9.067 -6.864 -4.327 1.00 96.05 O \\\\nATOM 1971 CG GLU A 246 11.927 -10.178 -2.493 1.00 96.05 C \\\\nATOM 1972 CD GLU A 246 11.932 -10.976 -1.182 1.00 96.05 C \\\\nATOM 1973 OE1 GLU A 246 12.596 -12.035 -1.169 1.00 96.05 O \\\\nATOM 1974 OE2 GLU A 246 11.300 -10.506 -0.211 1.00 96.05 O \\\\nATOM 1975 N THR A 247 8.223 -8.900 -4.741 1.00 97.28 N \\\\nATOM 1976 CA THR A 247 6.836 -8.416 -4.842 1.00 97.28 C \\\\nATOM 1977 C THR A 247 6.261 -8.242 -3.439 1.00 97.28 C \\\\nATOM 1978 CB THR A 247 5.942 -9.364 -5.659 1.00 97.28 C \\\\nATOM 1979 O THR A 247 6.203 -9.197 -2.663 1.00 97.28 O \\\\nATOM 1980 CG2 THR A 247 4.483 -8.934 -5.724 1.00 97.28 C \\\\nATOM 1981 OG1 THR A 247 6.361 -9.404 -7.003 1.00 97.28 O \\\\nATOM 1982 N PHE A 248 5.779 -7.043 -3.130 1.00 97.00 N \\\\nATOM 1983 CA PHE A 248 5.022 -6.783 -1.912 1.00 97.00 C \\\\nATOM 1984 C PHE A 248 3.574 -7.265 -2.077 1.00 97.00 C \\\\nATOM 1985 CB PHE A 248 5.102 -5.290 -1.588 1.00 97.00 C \\\\nATOM 1986 O PHE A 248 2.968 -7.046 -3.124 1.00 97.00 O \\\\nATOM 1987 CG PHE A 248 4.498 -4.937 -0.248 1.00 97.00 C \\\\nATOM 1988 CD1 PHE A 248 3.108 -4.751 -0.124 1.00 97.00 C \\\\nATOM 1989 CD2 PHE A 248 5.327 -4.822 0.884 1.00 97.00 C \\\\nATOM 1990 CE1 PHE A 248 2.550 -4.462 1.132 1.00 97.00 C \\\\nATOM 1991 CE2 PHE A 248 4.771 -4.501 2.134 1.00 97.00 C \\\\nATOM 1992 CZ PHE A 248 3.383 -4.322 2.254 1.00 97.00 C \\\\nATOM 1993 N HIS A 249 2.996 -7.886 -1.048 1.00 97.02 N \\\\nATOM 1994 CA HIS A 249 1.628 -8.415 -1.075 1.00 97.02 C \\\\nATOM 1995 C HIS A 249 0.777 -7.718 -0.006 1.00 97.02 C \\\\nATOM 1996 CB HIS A 249 1.668 -9.938 -0.893 1.00 97.02 C \\\\nATOM 1997 O HIS A 249 1.065 -7.816 1.186 1.00 97.02 O \\\\nATOM 1998 CG HIS A 249 2.379 -10.664 -2.010 1.00 97.02 C \\\\nATOM 1999 CD2 HIS A 249 1.784 -11.303 -3.065 1.00 97.02 C \\\\nATOM 2000 ND1 HIS A 249 3.740 -10.819 -2.165 1.00 97.02 N \\\\nATOM 2001 CE1 HIS A 249 3.954 -11.537 -3.277 1.00 97.02 C \\\\nATOM 2002 NE2 HIS A 249 2.791 -11.844 -3.870 1.00 97.02 N \\\\nATOM 2003 N ALA A 250 -0.265 -6.997 -0.425 1.00 95.01 N \\\\nATOM 2004 CA ALA A 250 -1.051 -6.142 0.459 1.00 95.01 C \\\\nATOM 2005 C ALA A 250 -2.266 -6.885 1.031 1.00 95.01 C \\\\nATOM 2006 CB ALA A 250 -1.460 -4.890 -0.323 1.00 95.01 C \\\\nATOM 2007 O ALA A 250 -3.233 -7.147 0.317 1.00 95.01 O \\\\nATOM 2008 N SER A 251 -2.227 -7.219 2.324 1.00 91.07 N \\\\nATOM 2009 CA SER A 251 -3.373 -7.794 3.047 1.00 91.07 C \\\\nATOM 2010 C SER A 251 -4.229 -6.731 3.737 1.00 91.07 C \\\\nATOM 2011 CB SER A 251 -2.896 -8.827 4.069 1.00 91.07 C \\\\nATOM 2012 O SER A 251 -5.447 -6.868 3.805 1.00 91.07 O \\\\nATOM 2013 OG SER A 251 -1.964 -8.254 4.975 1.00 91.07 O \\\\nATOM 2014 N GLN A 252 -3.615 -5.649 4.226 1.00 90.73 N \\\\nATOM 2015 CA GLN A 252 -4.331 -4.580 4.924 1.00 90.73 C \\\\nATOM 2016 C GLN A 252 -5.089 -3.667 3.945 1.00 90.73 C \\\\nATOM 2017 CB GLN A 252 -3.369 -3.767 5.810 1.00 90.73 C \\\\nATOM 2018 O GLN A 252 -4.523 -3.317 2.904 1.00 90.73 O \\\\nATOM 2019 CG GLN A 252 -2.758 -4.604 6.947 1.00 90.73 C \\\\nATOM 2020 CD GLN A 252 -3.801 -5.213 7.884 1.00 90.73 C \\\\nATOM 2021 NE2 GLN A 252 -3.472 -6.274 8.586 1.00 90.73 N \\\\nATOM 2022 OE1 GLN A 252 -4.936 -4.780 7.987 1.00 90.73 O \\\\nATOM 2023 N PRO A 253 -6.313 -3.194 4.272 1.00 90.20 N \\\\nATOM 2024 CA PRO A 253 -7.105 -2.315 3.397 1.00 90.20 C \\\\nATOM 2025 C PRO A 253 -6.448 -0.966 3.070 1.00 90.20 C \\\\nATOM 2026 CB PRO A 253 -8.428 -2.075 4.136 1.00 90.20 C \\\\nATOM 2027 O PRO A 253 -6.895 -0.256 2.175 1.00 90.20 O \\\\nATOM 2028 CG PRO A 253 -8.556 -3.278 5.064 1.00 90.20 C \\\\nATOM 2029 CD PRO A 253 -7.107 -3.576 5.437 1.00 90.20 C \\\\nATOM 2030 N SER A 254 -5.403 -0.580 3.802 1.00 93.37 N \\\\nATOM 2031 CA SER A 254 -4.603 0.618 3.560 1.00 93.37 C \\\\nATOM 2032 C SER A 254 -3.127 0.267 3.695 1.00 93.37 C \\\\nATOM 2033 CB SER A 254 -5.004 1.713 4.557 1.00 93.37 C \\\\nATOM 2034 O SER A 254 -2.726 -0.324 4.692 1.00 93.37 O \\\\nATOM 2035 OG SER A 254 -4.131 2.832 4.511 1.00 93.37 O \\\\nATOM 2036 N MET A 255 -2.311 0.706 2.741 1.00 95.32 N \\\\nATOM 2037 CA MET A 255 -0.854 0.588 2.792 1.00 95.32 C \\\\nATOM 2038 C MET A 255 -0.169 1.840 2.233 1.00 95.32 C \\\\nATOM 2039 CB MET A 255 -0.395 -0.682 2.060 1.00 95.32 C \\\\nATOM 2040 O MET A 255 -0.796 2.671 1.576 1.00 95.32 O \\\\nATOM 2041 CG MET A 255 -0.550 -0.591 0.534 1.00 95.32 C \\\\nATOM 2042 SD MET A 255 0.361 -1.848 -0.389 1.00 95.32 S \\\\nATOM 2043 CE MET A 255 2.074 -1.433 0.046 1.00 95.32 C \\\\nATOM 2044 N THR A 256 1.135 1.974 2.461 1.00 97.98 N \\\\nATOM 2045 CA THR A 256 1.963 3.043 1.885 1.00 97.98 C \\\\nATOM 2046 C THR A 256 3.144 2.443 1.129 1.00 97.98 C \\\\nATOM 2047 CB THR A 256 2.449 4.016 2.971 1.00 97.98 C \\\\nATOM 2048 O THR A 256 3.807 1.546 1.639 1.00 97.98 O \\\\nATOM 2049 CG2 THR A 256 3.014 5.307 2.385 1.00 97.98 C \\\\nATOM 2050 OG1 THR A 256 1.371 4.392 3.804 1.00 97.98 O \\\\nATOM 2051 N VAL A 257 3.434 2.942 -0.070 1.00 98.59 N \\\\nATOM 2052 CA VAL A 257 4.696 2.681 -0.775 1.00 98.59 C \\\\nATOM 2053 C VAL A 257 5.546 3.939 -0.637 1.00 98.59 C \\\\nATOM 2054 CB VAL A 257 4.466 2.311 -2.252 1.00 98.59 C \\\\nATOM 2055 O VAL A 257 5.147 4.992 -1.136 1.00 98.59 O \\\\nATOM 2056 CG1 VAL A 257 5.791 1.898 -2.897 1.00 98.59 C \\\\nATOM 2057 CG2 VAL A 257 3.451 1.175 -2.436 1.00 98.59 C \\\\nATOM 2058 N ASP A 258 6.672 3.861 0.073 1.00 98.59 N \\\\nATOM 2059 CA ASP A 258 7.464 5.030 0.481 1.00 98.59 C \\\\nATOM 2060 C ASP A 258 8.975 4.871 0.236 1.00 98.59 C \\\\nATOM 2061 CB ASP A 258 7.095 5.455 1.918 1.00 98.59 C \\\\nATOM 2062 O ASP A 258 9.464 3.803 -0.117 1.00 98.59 O \\\\nATOM 2063 CG ASP A 258 7.618 4.573 3.055 1.00 98.59 C \\\\nATOM 2064 OD1 ASP A 258 8.842 4.336 3.109 1.00 98.59 O \\\\nATOM 2065 OD2 ASP A 258 6.856 4.304 4.015 1.00 98.59 O \\\\nATOM 2066 N GLY A 259 9.722 5.970 0.356 1.00 98.35 N \\\\nATOM 2067 CA GLY A 259 11.163 6.037 0.098 1.00 98.35 C \\\\nATOM 2068 C GLY A 259 12.046 5.753 1.317 1.00 98.35 C \\\\nATOM 2069 O GLY A 259 13.248 6.001 1.246 1.00 98.35 O \\\\nATOM 2070 N PHE A 260 11.484 5.287 2.436 1.00 97.98 N \\\\nATOM 2071 CA PHE A 260 12.225 5.007 3.667 1.00 97.98 C \\\\nATOM 2072 C PHE A 260 12.692 3.537 3.722 1.00 97.98 C \\\\nATOM 2073 CB PHE A 260 11.377 5.441 4.874 1.00 97.98 C \\\\nATOM 2074 O PHE A 260 12.752 2.855 2.700 1.00 97.98 O \\\\nATOM 2075 CG PHE A 260 10.859 6.873 4.828 1.00 97.98 C \\\\nATOM 2076 CD1 PHE A 260 11.765 7.951 4.833 1.00 97.98 C \\\\nATOM 2077 CD2 PHE A 260 9.476 7.137 4.793 1.00 97.98 C \\\\nATOM 2078 CE1 PHE A 260 11.293 9.276 4.802 1.00 97.98 C \\\\nATOM 2079 CE2 PHE A 260 9.002 8.460 4.769 1.00 97.98 C \\\\nATOM 2080 CZ PHE A 260 9.911 9.533 4.771 1.00 97.98 C \\\\nATOM 2081 N THR A 261 13.114 3.057 4.898 1.00 97.45 N \\\\nATOM 2082 CA THR A 261 13.944 1.843 5.042 1.00 97.45 C \\\\nATOM 2083 C THR A 261 13.457 0.865 6.124 1.00 97.45 C \\\\nATOM 2084 CB THR A 261 15.413 2.228 5.303 1.00 97.45 C \\\\nATOM 2085 O THR A 261 14.274 0.237 6.791 1.00 97.45 O \\\\nATOM 2086 CG2 THR A 261 16.016 3.142 4.236 1.00 97.45 C \\\\nATOM 2087 OG1 THR A 261 15.497 2.905 6.536 1.00 97.45 O \\\\nATOM 2088 N ASP A 262 12.148 0.768 6.359 1.00 95.17 N \\\\nATOM 2089 CA ASP A 262 11.557 -0.171 7.330 1.00 95.17 C \\\\nATOM 2090 C ASP A 262 11.226 -1.508 6.631 1.00 95.17 C \\\\nATOM 2091 CB ASP A 262 10.329 0.514 7.949 1.00 95.17 C \\\\nATOM 2092 O ASP A 262 10.349 -1.517 5.765 1.00 95.17 O \\\\nATOM 2093 CG ASP A 262 9.506 -0.309 8.941 1.00 95.17 C \\\\nATOM 2094 OD1 ASP A 262 9.875 -1.471 9.213 1.00 95.17 O \\\\nATOM 2095 OD2 ASP A 262 8.501 0.287 9.413 1.00 95.17 O \\\\nATOM 2096 N PRO A 263 11.930 -2.617 6.940 1.00 92.14 N \\\\nATOM 2097 CA PRO A 263 11.783 -3.882 6.221 1.00 92.14 C \\\\nATOM 2098 C PRO A 263 10.658 -4.780 6.757 1.00 92.14 C \\\\nATOM 2099 CB PRO A 263 13.144 -4.569 6.390 1.00 92.14 C \\\\nATOM 2100 O PRO A 263 10.397 -5.820 6.161 1.00 92.14 O \\\\nATOM 2101 CG PRO A 263 13.546 -4.156 7.805 1.00 92.14 C \\\\nATOM 2102 CD PRO A 263 13.025 -2.721 7.898 1.00 92.14 C \\\\nATOM 2103 N SER A 264 10.043 -4.456 7.901 1.00 89.29 N \\\\nATOM 2104 CA SER A 264 9.228 -5.412 8.675 1.00 89.29 C \\\\nATOM 2105 C SER A 264 7.748 -5.047 8.797 1.00 89.29 C \\\\nATOM 2106 CB SER A 264 9.852 -5.611 10.058 1.00 89.29 C \\\\nATOM 2107 O SER A 264 6.975 -5.786 9.409 1.00 89.29 O \\\\nATOM 2108 OG SER A 264 9.904 -4.393 10.775 1.00 89.29 O \\\\nATOM 2109 N ASN A 265 7.334 -3.917 8.228 1.00 88.56 N \\\\nATOM 2110 CA ASN A 265 5.992 -3.379 8.391 1.00 88.56 C \\\\nATOM 2111 C ASN A 265 5.062 -3.788 7.234 1.00 88.56 C \\\\nATOM 2112 CB ASN A 265 6.154 -1.869 8.581 1.00 88.56 C \\\\nATOM 2113 O ASN A 265 5.209 -3.325 6.106 1.00 88.56 O \\\\nATOM 2114 CG ASN A 265 4.866 -1.162 8.931 1.00 88.56 C \\\\nATOM 2115 ND2 ASN A 265 4.961 -0.102 9.695 1.00 88.56 N \\\\nATOM 2116 OD1 ASN A 265 3.773 -1.539 8.554 1.00 88.56 O \\\\nATOM 2117 N SER A 266 4.054 -4.613 7.527 1.00 89.15 N \\\\nATOM 2118 CA SER A 266 3.077 -5.123 6.550 1.00 89.15 C \\\\nATOM 2119 C SER A 266 2.102 -4.074 5.990 1.00 89.15 C \\\\nATOM 2120 CB SER A 266 2.299 -6.287 7.168 1.00 89.15 C \\\\nATOM 2121 O SER A 266 1.358 -4.377 5.060 1.00 89.15 O \\\\nATOM 2122 OG SER A 266 1.744 -5.908 8.415 1.00 89.15 O \\\\nATOM 2123 N GLU A 267 2.116 -2.839 6.498 1.00 92.42 N \\\\nATOM 2124 CA GLU A 267 1.410 -1.688 5.916 1.00 92.42 C \\\\nATOM 2125 C GLU A 267 2.337 -0.796 5.064 1.00 92.42 C \\\\nATOM 2126 CB GLU A 267 0.740 -0.852 7.025 1.00 92.42 C \\\\nATOM 2127 O GLU A 267 1.879 0.211 4.517 1.00 92.42 O \\\\nATOM 2128 CG GLU A 267 -0.372 -1.588 7.791 1.00 92.42 C \\\\nATOM 2129 CD GLU A 267 -0.968 -0.749 8.942 1.00 92.42 C \\\\nATOM 2130 OE1 GLU A 267 -1.641 -1.347 9.812 1.00 92.42 O \\\\nATOM 2131 OE2 GLU A 267 -0.756 0.490 8.978 1.00 92.42 O \\\\nATOM 2132 N ARG A 268 3.642 -1.106 4.951 1.00 96.71 N \\\\nATOM 2133 CA ARG A 268 4.633 -0.235 4.295 1.00 96.71 C \\\\nATOM 2134 C ARG A 268 5.581 -0.984 3.360 1.00 96.71 C \\\\nATOM 2135 CB ARG A 268 5.451 0.535 5.336 1.00 96.71 C \\\\nATOM 2136 O ARG A 268 6.459 -1.720 3.799 1.00 96.71 O \\\\nATOM 2137 CG ARG A 268 4.598 1.470 6.205 1.00 96.71 C \\\\nATOM 2138 CD ARG A 268 5.471 2.197 7.229 1.00 96.71 C \\\\nATOM 2139 NE ARG A 268 6.461 3.067 6.578 1.00 96.71 N \\\\nATOM 2140 NH1 ARG A 268 8.178 2.875 8.116 1.00 96.71 N \\\\nATOM 2141 NH2 ARG A 268 8.428 4.071 6.252 1.00 96.71 N \\\\nATOM 2142 CZ ARG A 268 7.677 3.330 7.000 1.00 96.71 C \\\\nATOM 2143 N PHE A 269 5.496 -0.685 2.067 1.00 97.68 N \\\\nATOM 2144 CA PHE A 269 6.505 -1.092 1.095 1.00 97.68 C \\\\nATOM 2145 C PHE A 269 7.594 -0.013 0.995 1.00 97.68 C \\\\nATOM 2146 CB PHE A 269 5.841 -1.419 -0.246 1.00 97.68 C \\\\nATOM 2147 O PHE A 269 7.465 0.977 0.272 1.00 97.68 O \\\\nATOM 2148 CG PHE A 269 6.732 -2.035 -1.317 1.00 97.68 C \\\\nATOM 2149 CD1 PHE A 269 6.290 -2.019 -2.654 1.00 97.68 C \\\\nATOM 2150 CD2 PHE A 269 7.951 -2.678 -1.003 1.00 97.68 C \\\\nATOM 2151 CE1 PHE A 269 7.051 -2.635 -3.663 1.00 97.68 C \\\\nATOM 2152 CE2 PHE A 269 8.709 -3.292 -2.014 1.00 97.68 C \\\\nATOM 2153 CZ PHE A 269 8.260 -3.274 -3.343 1.00 97.68 C \\\\nATOM 2154 N CYS A 270 8.660 -0.192 1.772 1.00 97.96 N \\\\nATOM 2155 CA CYS A 270 9.772 0.749 1.880 1.00 97.96 C \\\\nATOM 2156 C CYS A 270 10.801 0.547 0.756 1.00 97.96 C \\\\nATOM 2157 CB CYS A 270 10.393 0.560 3.264 1.00 97.96 C \\\\nATOM 2158 O CYS A 270 11.706 -0.278 0.855 1.00 97.96 O \\\\nATOM 2159 SG CYS A 270 9.279 1.227 4.523 1.00 97.96 S \\\\nATOM 2160 N LEU A 271 10.700 1.336 -0.313 1.00 98.37 N \\\\nATOM 2161 CA LEU A 271 11.570 1.252 -1.490 1.00 98.37 C \\\\nATOM 2162 C LEU A 271 13.017 1.677 -1.204 1.00 98.37 C \\\\nATOM 2163 CB LEU A 271 10.985 2.129 -2.613 1.00 98.37 C \\\\nATOM 2164 O LEU A 271 13.931 1.282 -1.934 1.00 98.37 O \\\\nATOM 2165 CG LEU A 271 9.530 1.812 -3.013 1.00 98.37 C \\\\nATOM 2166 CD1 LEU A 271 9.126 2.737 -4.161 1.00 98.37 C \\\\nATOM 2167 CD2 LEU A 271 9.361 0.360 -3.452 1.00 98.37 C \\\\nATOM 2168 N GLY A 272 13.246 2.484 -0.163 1.00 97.79 N \\\\nATOM 2169 CA GLY A 272 14.545 3.069 0.179 1.00 97.79 C \\\\nATOM 2170 C GLY A 272 15.617 2.040 0.545 1.00 97.79 C \\\\nATOM 2171 O GLY A 272 16.781 2.254 0.210 1.00 97.79 O \\\\nATOM 2172 N LEU A 273 15.226 0.906 1.141 1.00 96.65 N \\\\nATOM 2173 CA LEU A 273 16.139 -0.196 1.493 1.00 96.65 C \\\\nATOM 2174 C LEU A 273 16.521 -1.096 0.307 1.00 96.65 C \\\\nATOM 2175 CB LEU A 273 15.547 -1.007 2.665 1.00 96.65 C \\\\nATOM 2176 O LEU A 273 17.466 -1.872 0.412 1.00 96.65 O \\\\nATOM 2177 CG LEU A 273 14.300 -1.851 2.311 1.00 96.65 C \\\\nATOM 2178 CD1 LEU A 273 14.642 -3.321 2.064 1.00 96.65 C \\\\nATOM 2179 CD2 LEU A 273 13.283 -1.793 3.449 1.00 96.65 C \\\\nATOM 2180 N LEU A 274 15.799 -1.014 -0.815 1.00 97.53 N \\\\nATOM 2181 CA LEU A 274 16.035 -1.883 -1.966 1.00 97.53 C \\\\nATOM 2182 C LEU A 274 17.331 -1.493 -2.693 1.00 97.53 C \\\\nATOM 2183 CB LEU A 274 14.819 -1.875 -2.911 1.00 97.53 C \\\\nATOM 2184 O LEU A 274 17.503 -0.348 -3.127 1.00 97.53 O \\\\nATOM 2185 CG LEU A 274 13.475 -2.263 -2.261 1.00 97.53 C \\\\nATOM 2186 CD1 LEU A 274 12.360 -2.159 -3.298 1.00 97.53 C \\\\nATOM 2187 CD2 LEU A 274 13.486 -3.689 -1.708 1.00 97.53 C \\\\nATOM 2188 N SER A 275 18.231 -2.457 -2.866 1.00 97.29 N \\\\nATOM 2189 CA SER A 275 19.495 -2.297 -3.593 1.00 97.29 C \\\\nATOM 2190 C SER A 275 19.337 -2.595 -5.084 1.00 97.29 C \\\\nATOM 2191 CB SER A 275 20.570 -3.202 -2.989 1.00 97.29 C \\\\nATOM 2192 O SER A 275 18.613 -3.508 -5.468 1.00 97.29 O \\\\nATOM 2193 OG SER A 275 20.889 -2.729 -1.698 1.00 97.29 O \\\\nATOM 2194 N ASN A 276 20.062 -1.854 -5.922 1.00 97.60 N \\\\nATOM 2195 CA ASN A 276 20.222 -2.133 -7.348 1.00 97.60 C \\\\nATOM 2196 C ASN A 276 21.642 -1.728 -7.766 1.00 97.60 C \\\\nATOM 2197 CB ASN A 276 19.150 -1.372 -8.147 1.00 97.60 C \\\\nATOM 2198 O ASN A 276 22.036 -0.583 -7.550 1.00 97.60 O \\\\nATOM 2199 CG ASN A 276 19.281 -1.562 -9.649 1.00 97.60 C \\\\nATOM 2200 ND2 ASN A 276 18.599 -0.758 -10.423 1.00 97.60 N \\\\nATOM 2201 OD1 ASN A 276 20.009 -2.418 -10.132 1.00 97.60 O \\\\nATOM 2202 N VAL A 277 22.401 -2.660 -8.347 1.00 97.53 N \\\\nATOM 2203 CA VAL A 277 23.790 -2.432 -8.788 1.00 97.53 C \\\\nATOM 2204 C VAL A 277 23.883 -1.607 -10.075 1.00 97.53 C \\\\nATOM 2205 CB VAL A 277 24.560 -3.758 -8.942 1.00 97.53 C \\\\nATOM 2206 O VAL A 277 24.888 -0.944 -10.296 1.00 97.53 O \\\\nATOM 2207 CG1 VAL A 277 24.703 -4.463 -7.586 1.00 97.53 C \\\\nATOM 2208 CG2 VAL A 277 23.902 -4.734 -9.928 1.00 97.53 C \\\\nATOM 2209 N ASN A 278 22.820 -1.582 -10.886 1.00 97.11 N \\\\nATOM 2210 CA ASN A 278 22.754 -0.822 -12.142 1.00 97.11 C \\\\nATOM 2211 C ASN A 278 22.172 0.592 -11.951 1.00 97.11 C \\\\nATOM 2212 CB ASN A 278 21.926 -1.625 -13.154 1.00 97.11 C \\\\nATOM 2213 O ASN A 278 21.821 1.276 -12.916 1.00 97.11 O \\\\nATOM 2214 CG ASN A 278 22.476 -3.007 -13.444 1.00 97.11 C \\\\nATOM 2215 ND2 ASN A 278 21.611 -3.949 -13.725 1.00 97.11 N \\\\nATOM 2216 OD1 ASN A 278 23.666 -3.263 -13.422 1.00 97.11 O \\\\nATOM 2217 N ARG A 279 21.996 1.027 -10.698 1.00 97.96 N \\\\nATOM 2218 CA ARG A 279 21.340 2.290 -10.366 1.00 97.96 C \\\\nATOM 2219 C ARG A 279 22.193 3.478 -10.809 1.00 97.96 C \\\\nATOM 2220 CB ARG A 279 21.060 2.312 -8.863 1.00 97.96 C \\\\nATOM 2221 O ARG A 279 23.320 3.644 -10.360 1.00 97.96 O \\\\nATOM 2222 CG ARG A 279 20.244 3.545 -8.475 1.00 97.96 C \\\\nATOM 2223 CD ARG A 279 19.859 3.495 -6.999 1.00 97.96 C \\\\nATOM 2224 NE ARG A 279 18.879 2.424 -6.746 1.00 97.96 N \\\\nATOM 2225 NH1 ARG A 279 19.536 1.773 -4.627 1.00 97.96 N \\\\nATOM 2226 NH2 ARG A 279 17.786 0.836 -5.597 1.00 97.96 N \\\\nATOM 2227 CZ ARG A 279 18.752 1.686 -5.665 1.00 97.96 C \\\\nATOM 2228 N ASN A 280 21.625 4.343 -11.646 1.00 98.01 N \\\\nATOM 2229 CA ASN A 280 22.284 5.575 -12.082 1.00 98.01 C \\\\nATOM 2230 C ASN A 280 21.891 6.792 -11.219 1.00 98.01 C \\\\nATOM 2231 CB ASN A 280 22.066 5.759 -13.597 1.00 98.01 C \\\\nATOM 2232 O ASN A 280 20.905 6.771 -10.476 1.00 98.01 O \\\\nATOM 2233 CG ASN A 280 20.659 6.171 -13.997 1.00 98.01 C \\\\nATOM 2234 ND2 ASN A 280 20.158 5.652 -15.090 1.00 98.01 N \\\\nATOM 2235 OD1 ASN A 280 20.010 6.991 -13.367 1.00 98.01 O \\\\nATOM 2236 N ALA A 281 22.632 7.894 -11.368 1.00 98.22 N \\\\nATOM 2237 CA ALA A 281 22.433 9.122 -10.594 1.00 98.22 C \\\\nATOM 2238 C ALA A 281 21.018 9.732 -10.717 1.00 98.22 C \\\\nATOM 2239 CB ALA A 281 23.501 10.127 -11.044 1.00 98.22 C \\\\nATOM 2240 O ALA A 281 20.518 10.328 -9.762 1.00 98.22 O \\\\nATOM 2241 N ALA A 282 20.339 9.570 -11.860 1.00 97.51 N \\\\nATOM 2242 CA ALA A 282 18.974 10.067 -12.047 1.00 97.51 C \\\\nATOM 2243 C ALA A 282 17.950 9.249 -11.239 1.00 97.51 C \\\\nATOM 2244 CB ALA A 282 18.643 10.075 -13.544 1.00 97.51 C \\\\nATOM 2245 O ALA A 282 16.999 9.815 -10.689 1.00 97.51 O \\\\nATOM 2246 N VAL A 283 18.165 7.934 -11.122 1.00 98.47 N \\\\nATOM 2247 CA VAL A 283 17.389 7.047 -10.245 1.00 98.47 C \\\\nATOM 2248 C VAL A 283 17.664 7.375 -8.778 1.00 98.47 C \\\\nATOM 2249 CB VAL A 283 17.676 5.565 -10.555 1.00 98.47 C \\\\nATOM 2250 O VAL A 283 16.717 7.591 -8.027 1.00 98.47 O \\\\nATOM 2251 CG1 VAL A 283 16.889 4.649 -9.617 1.00 98.47 C \\\\nATOM 2252 CG2 VAL A 283 17.304 5.177 -11.993 1.00 98.47 C \\\\nATOM 2253 N GLU A 284 18.928 7.516 -8.364 1.00 98.10 N \\\\nATOM 2254 CA GLU A 284 19.264 7.908 -6.985 1.00 98.10 C \\\\nATOM 2255 C GLU A 284 18.616 9.230 -6.565 1.00 98.10 C \\\\nATOM 2256 CB GLU A 284 20.767 8.100 -6.802 1.00 98.10 C \\\\nATOM 2257 O GLU A 284 18.015 9.320 -5.492 1.00 98.10 O \\\\nATOM 2258 CG GLU A 284 21.591 6.819 -6.912 1.00 98.10 C \\\\nATOM 2259 CD GLU A 284 23.012 7.033 -6.376 1.00 98.10 C \\\\nATOM 2260 OE1 GLU A 284 23.693 6.005 -6.206 1.00 98.10 O \\\\nATOM 2261 OE2 GLU A 284 23.355 8.200 -6.052 1.00 98.10 O \\\\nATOM 2262 N LEU A 285 18.712 10.256 -7.416 1.00 97.88 N \\\\nATOM 2263 CA LEU A 285 18.103 11.557 -7.160 1.00 97.88 C \\\\nATOM 2264 C LEU A 285 16.577 11.448 -7.064 1.00 97.88 C \\\\nATOM 2265 CB LEU A 285 18.540 12.528 -8.271 1.00 97.88 C \\\\nATOM 2266 O LEU A 285 15.972 12.091 -6.209 1.00 97.88 O \\\\nATOM 2267 CG LEU A 285 18.038 13.971 -8.080 1.00 97.88 C \\\\nATOM 2268 CD1 LEU A 285 18.614 14.620 -6.819 1.00 97.88 C \\\\nATOM 2269 CD2 LEU A 285 18.441 14.815 -9.287 1.00 97.88 C \\\\nATOM 2270 N THR A 286 15.953 10.614 -7.899 1.00 98.50 N \\\\nATOM 2271 CA THR A 286 14.501 10.386 -7.877 1.00 98.50 C \\\\nATOM 2272 C THR A 286 14.064 9.674 -6.596 1.00 98.50 C \\\\nATOM 2273 CB THR A 286 14.054 9.625 -9.133 1.00 98.50 C \\\\nATOM 2274 O THR A 286 13.122 10.129 -5.949 1.00 98.50 O \\\\nATOM 2275 CG2 THR A 286 12.547 9.397 -9.178 1.00 98.50 C \\\\nATOM 2276 OG1 THR A 286 14.390 10.398 -10.269 1.00 98.50 O \\\\nATOM 2277 N ARG A 287 14.794 8.638 -6.154 1.00 98.55 N \\\\nATOM 2278 CA ARG A 287 14.523 7.904 -4.901 1.00 98.55 C \\\\nATOM 2279 C ARG A 287 14.482 8.822 -3.678 1.00 98.55 C \\\\nATOM 2280 CB ARG A 287 15.564 6.790 -4.704 1.00 98.55 C \\\\nATOM 2281 O ARG A 287 13.576 8.694 -2.859 1.00 98.55 O \\\\nATOM 2282 CG ARG A 287 15.359 5.631 -5.690 1.00 98.55 C \\\\nATOM 2283 CD ARG A 287 16.531 4.646 -5.688 1.00 98.55 C \\\\nATOM 2284 NE ARG A 287 16.726 3.989 -4.382 1.00 98.55 N \\\\nATOM 2285 NH1 ARG A 287 15.047 2.408 -4.548 1.00 98.55 N \\\\nATOM 2286 NH2 ARG A 287 16.237 2.559 -2.695 1.00 98.55 N \\\\nATOM 2287 CZ ARG A 287 16.004 2.997 -3.893 1.00 98.55 C \\\\nATOM 2288 N ARG A 288 15.396 9.799 -3.592 1.00 98.14 N \\\\nATOM 2289 CA ARG A 288 15.428 10.806 -2.505 1.00 98.14 C \\\\nATOM 2290 C ARG A 288 14.143 11.644 -2.420 1.00 98.14 C \\\\nATOM 2291 CB ARG A 288 16.650 11.731 -2.667 1.00 98.14 C \\\\nATOM 2292 O ARG A 288 13.778 12.070 -1.332 1.00 98.14 O \\\\nATOM 2293 CG ARG A 288 17.993 11.000 -2.498 1.00 98.14 C \\\\nATOM 2294 CD ARG A 288 19.181 11.901 -2.874 1.00 98.14 C \\\\nATOM 2295 NE ARG A 288 20.398 11.107 -3.150 1.00 98.14 N \\\\nATOM 2296 NH1 ARG A 288 21.675 12.765 -4.097 1.00 98.14 N \\\\nATOM 2297 NH2 ARG A 288 22.412 10.662 -4.146 1.00 98.14 N \\\\nATOM 2298 CZ ARG A 288 21.488 11.511 -3.787 1.00 98.14 C \\\\nATOM 2299 N HIS A 289 13.449 11.845 -3.541 1.00 98.35 N \\\\nATOM 2300 CA HIS A 289 12.217 12.635 -3.628 1.00 98.35 C \\\\nATOM 2301 C HIS A 289 10.932 11.800 -3.487 1.00 98.35 C \\\\nATOM 2302 CB HIS A 289 12.228 13.443 -4.933 1.00 98.35 C \\\\nATOM 2303 O HIS A 289 9.845 12.371 -3.441 1.00 98.35 O \\\\nATOM 2304 CG HIS A 289 13.279 14.519 -4.971 1.00 98.35 C \\\\nATOM 2305 CD2 HIS A 289 13.114 15.837 -4.644 1.00 98.35 C \\\\nATOM 2306 ND1 HIS A 289 14.587 14.359 -5.363 1.00 98.35 N \\\\nATOM 2307 CE1 HIS A 289 15.198 15.549 -5.271 1.00 98.35 C \\\\nATOM 2308 NE2 HIS A 289 14.339 16.483 -4.845 1.00 98.35 N \\\\nATOM 2309 N ILE A 290 11.017 10.466 -3.369 1.00 98.63 N \\\\nATOM 2310 CA ILE A 290 9.841 9.639 -3.050 1.00 98.63 C \\\\nATOM 2311 C ILE A 290 9.306 10.043 -1.671 1.00 98.63 C \\\\nATOM 2312 CB ILE A 290 10.157 8.125 -3.141 1.00 98.63 C \\\\nATOM 2313 O ILE A 290 8.115 10.314 -1.533 1.00 98.63 O \\\\nATOM 2314 CG1 ILE A 290 10.603 7.762 -4.577 1.00 98.63 C \\\\nATOM 2315 CG2 ILE A 290 8.930 7.285 -2.733 1.00 98.63 C \\\\nATOM 2316 CD1 ILE A 290 11.006 6.296 -4.777 1.00 98.63 C \\\\nATOM 2317 N GLY A 291 10.179 10.159 -0.662 1.00 97.93 N \\\\nATOM 2318 CA GLY A 291 9.796 10.581 0.688 1.00 97.93 C \\\\nATOM 2319 C GLY A 291 8.689 9.692 1.258 1.00 97.93 C \\\\nATOM 2320 O GLY A 291 8.837 8.476 1.311 1.00 97.93 O \\\\nATOM 2321 N ARG A 292 7.549 10.284 1.631 1.00 97.98 N \\\\nATOM 2322 CA ARG A 292 6.356 9.552 2.107 1.00 97.98 C \\\\nATOM 2323 C ARG A 292 5.579 8.813 1.001 1.00 97.98 C \\\\nATOM 2324 CB ARG A 292 5.429 10.523 2.843 1.00 97.98 C \\\\nATOM 2325 O ARG A 292 4.648 8.084 1.323 1.00 97.98 O \\\\nATOM 2326 CG ARG A 292 6.043 11.155 4.102 1.00 97.98 C \\\\nATOM 2327 CD ARG A 292 5.155 12.291 4.625 1.00 97.98 C \\\\nATOM 2328 NE ARG A 292 3.816 11.807 5.025 1.00 97.98 N \\\\nATOM 2329 NH1 ARG A 292 2.560 13.478 4.052 1.00 97.98 N \\\\nATOM 2330 NH2 ARG A 292 1.550 11.850 5.190 1.00 97.98 N \\\\nATOM 2331 CZ ARG A 292 2.657 12.386 4.757 1.00 97.98 C \\\\nATOM 2332 N GLY A 293 5.940 9.013 -0.267 1.00 98.48 N \\\\nATOM 2333 CA GLY A 293 5.458 8.255 -1.421 1.00 98.48 C \\\\nATOM 2334 C GLY A 293 3.948 8.325 -1.660 1.00 98.48 C \\\\nATOM 2335 O GLY A 293 3.371 9.413 -1.711 1.00 98.48 O \\\\nATOM 2336 N VAL A 294 3.316 7.167 -1.851 1.00 98.76 N \\\\nATOM 2337 CA VAL A 294 1.883 7.027 -2.148 1.00 98.76 C \\\\nATOM 2338 C VAL A 294 1.199 6.162 -1.095 1.00 98.76 C \\\\nATOM 2339 CB VAL A 294 1.649 6.501 -3.583 1.00 98.76 C \\\\nATOM 2340 O VAL A 294 1.681 5.080 -0.764 1.00 98.76 O \\\\nATOM 2341 CG1 VAL A 294 2.258 5.122 -3.865 1.00 98.76 C \\\\nATOM 2342 CG2 VAL A 294 0.160 6.438 -3.941 1.00 98.76 C \\\\nATOM 2343 N ARG A 295 0.049 6.616 -0.588 1.00 98.09 N \\\\nATOM 2344 CA ARG A 295 -0.880 5.762 0.159 1.00 98.09 C \\\\nATOM 2345 C ARG A 295 -1.883 5.153 -0.811 1.00 98.09 C \\\\nATOM 2346 CB ARG A 295 -1.528 6.533 1.317 1.00 98.09 C \\\\nATOM 2347 O ARG A 295 -2.517 5.875 -1.576 1.00 98.09 O \\\\nATOM 2348 CG ARG A 295 -2.630 5.709 1.999 1.00 98.09 C \\\\nATOM 2349 CD ARG A 295 -3.123 6.304 3.319 1.00 98.09 C \\\\nATOM 2350 NE ARG A 295 -3.835 7.594 3.177 1.00 98.09 N \\\\nATOM 2351 NH1 ARG A 295 -4.351 7.823 5.400 1.00 98.09 N \\\\nATOM 2352 NH2 ARG A 295 -4.968 9.401 4.026 1.00 98.09 N \\\\nATOM 2353 CZ ARG A 295 -4.365 8.267 4.180 1.00 98.09 C \\\\nATOM 2354 N LEU A 296 -2.036 3.839 -0.738 1.00 98.08 N \\\\nATOM 2355 CA LEU A 296 -3.010 3.062 -1.490 1.00 98.08 C \\\\nATOM 2356 C LEU A 296 -4.043 2.516 -0.509 1.00 98.08 C \\\\nATOM 2357 CB LEU A 296 -2.294 1.924 -2.231 1.00 98.08 C \\\\nATOM 2358 O LEU A 296 -3.667 2.012 0.551 1.00 98.08 O \\\\nATOM 2359 CG LEU A 296 -1.248 2.381 -3.261 1.00 98.08 C \\\\nATOM 2360 CD1 LEU A 296 -0.411 1.178 -3.685 1.00 98.08 C \\\\nATOM 2361 CD2 LEU A 296 -1.904 3.007 -4.492 1.00 98.08 C \\\\nATOM 2362 N TYR A 297 -5.329 2.623 -0.832 1.00 95.51 N \\\\nATOM 2363 CA TYR A 297 -6.385 2.059 0.007 1.00 95.51 C \\\\nATOM 2364 C TYR A 297 -7.529 1.468 -0.814 1.00 95.51 C \\\\nATOM 2365 CB TYR A 297 -6.864 3.077 1.057 1.00 95.51 C \\\\nATOM 2366 O TYR A 297 -7.959 2.065 -1.801 1.00 95.51 O \\\\nATOM 2367 CG TYR A 297 -7.340 4.429 0.545 1.00 95.51 C \\\\nATOM 2368 CD1 TYR A 297 -6.414 5.466 0.324 1.00 95.51 C \\\\nATOM 2369 CD2 TYR A 297 -8.708 4.666 0.320 1.00 95.51 C \\\\nATOM 2370 CE1 TYR A 297 -6.849 6.736 -0.100 1.00 95.51 C \\\\nATOM 2371 CE2 TYR A 297 -9.157 5.940 -0.083 1.00 95.51 C \\\\nATOM 2372 OH TYR A 297 -8.632 8.188 -0.768 1.00 95.51 O \\\\nATOM 2373 CZ TYR A 297 -8.223 6.975 -0.311 1.00 95.51 C \\\\nATOM 2374 N TYR A 298 -8.002 0.301 -0.375 1.00 94.74 N \\\\nATOM 2375 CA TYR A 298 -9.119 -0.454 -0.933 1.00 94.74 C \\\\nATOM 2376 C TYR A 298 -10.305 -0.400 0.031 1.00 94.74 C \\\\nATOM 2377 CB TYR A 298 -8.687 -1.901 -1.202 1.00 94.74 C \\\\nATOM 2378 O TYR A 298 -10.216 -0.871 1.165 1.00 94.74 O \\\\nATOM 2379 CG TYR A 298 -9.816 -2.794 -1.687 1.00 94.74 C \\\\nATOM 2380 CD1 TYR A 298 -10.159 -3.964 -0.979 1.00 94.74 C \\\\nATOM 2381 CD2 TYR A 298 -10.533 -2.448 -2.849 1.00 94.74 C \\\\nATOM 2382 CE1 TYR A 298 -11.210 -4.787 -1.436 1.00 94.74 C \\\\nATOM 2383 CE2 TYR A 298 -11.572 -3.276 -3.314 1.00 94.74 C \\\\nATOM 2384 OH TYR A 298 -12.949 -5.212 -3.055 1.00 94.74 O \\\\nATOM 2385 CZ TYR A 298 -11.919 -4.446 -2.607 1.00 94.74 C \\\\nATOM 2386 N ILE A 299 -11.394 0.244 -0.388 1.00 91.25 N \\\\nATOM 2387 CA ILE A 299 -12.558 0.535 0.455 1.00 91.25 C \\\\nATOM 2388 C ILE A 299 -13.815 0.469 -0.405 1.00 91.25 C \\\\nATOM 2389 CB ILE A 299 -12.423 1.927 1.118 1.00 91.25 C \\\\nATOM 2390 O ILE A 299 -13.893 1.129 -1.436 1.00 91.25 O \\\\nATOM 2391 CG1 ILE A 299 -11.142 1.993 1.981 1.00 91.25 C \\\\nATOM 2392 CG2 ILE A 299 -13.670 2.255 1.966 1.00 91.25 C \\\\nATOM 2393 CD1 ILE A 299 -10.920 3.332 2.662 1.00 91.25 C \\\\nATOM 2394 N GLY A 300 -14.817 -0.298 0.027 1.00 87.74 N \\\\nATOM 2395 CA GLY A 300 -16.122 -0.324 -0.635 1.00 87.74 C \\\\nATOM 2396 C GLY A 300 -16.095 -0.843 -2.079 1.00 87.74 C \\\\nATOM 2397 O GLY A 300 -16.918 -0.420 -2.883 1.00 87.74 O \\\\nATOM 2398 N GLY A 301 -15.134 -1.703 -2.439 1.00 92.50 N \\\\nATOM 2399 CA GLY A 301 -14.932 -2.138 -3.827 1.00 92.50 C \\\\nATOM 2400 C GLY A 301 -14.189 -1.123 -4.709 1.00 92.50 C \\\\nATOM 2401 O GLY A 301 -14.130 -1.302 -5.923 1.00 92.50 O \\\\nATOM 2402 N GLU A 302 -13.621 -0.061 -4.133 1.00 96.35 N \\\\nATOM 2403 CA GLU A 302 -12.888 0.985 -4.850 1.00 96.35 C \\\\nATOM 2404 C GLU A 302 -11.437 1.070 -4.369 1.00 96.35 C \\\\nATOM 2405 CB GLU A 302 -13.577 2.348 -4.682 1.00 96.35 C \\\\nATOM 2406 O GLU A 302 -11.167 0.962 -3.172 1.00 96.35 O \\\\nATOM 2407 CG GLU A 302 -15.088 2.312 -4.939 1.00 96.35 C \\\\nATOM 2408 CD GLU A 302 -15.652 3.709 -5.205 1.00 96.35 C \\\\nATOM 2409 OE1 GLU A 302 -16.276 3.889 -6.275 1.00 96.35 O \\\\nATOM 2410 OE2 GLU A 302 -15.407 4.677 -4.447 1.00 96.35 O \\\\nATOM 2411 N VAL A 303 -10.497 1.306 -5.288 1.00 97.65 N \\\\nATOM 2412 CA VAL A 303 -9.086 1.555 -4.958 1.00 97.65 C \\\\nATOM 2413 C VAL A 303 -8.758 3.017 -5.223 1.00 97.65 C \\\\nATOM 2414 CB VAL A 303 -8.101 0.632 -5.703 1.00 97.65 C \\\\nATOM 2415 O VAL A 303 -9.085 3.566 -6.279 1.00 97.65 O \\\\nATOM 2416 CG1 VAL A 303 -6.685 0.759 -5.122 1.00 97.65 C \\\\nATOM 2417 CG2 VAL A 303 -8.473 -0.853 -5.616 1.00 97.65 C \\\\nATOM 2418 N PHE A 304 -8.050 3.639 -4.287 1.00 98.07 N \\\\nATOM 2419 CA PHE A 304 -7.582 5.017 -4.387 1.00 98.07 C \\\\nATOM 2420 C PHE A 304 -6.065 5.109 -4.219 1.00 98.07 C \\\\nATOM 2421 CB PHE A 304 -8.259 5.861 -3.314 1.00 98.07 C \\\\nATOM 2422 O PHE A 304 -5.465 4.343 -3.462 1.00 98.07 O \\\\nATOM 2423 CG PHE A 304 -9.768 5.994 -3.396 1.00 98.07 C \\\\nATOM 2424 CD1 PHE A 304 -10.346 7.178 -3.895 1.00 98.07 C \\\\nATOM 2425 CD2 PHE A 304 -10.598 4.970 -2.898 1.00 98.07 C \\\\nATOM 2426 CE1 PHE A 304 -11.745 7.331 -3.908 1.00 98.07 C \\\\nATOM 2427 CE2 PHE A 304 -11.993 5.130 -2.902 1.00 98.07 C \\\\nATOM 2428 CZ PHE A 304 -12.568 6.303 -3.416 1.00 98.07 C \\\\nATOM 2429 N ALA A 305 -5.465 6.102 -4.876 1.00 98.57 N \\\\nATOM 2430 CA ALA A 305 -4.087 6.528 -4.654 1.00 98.57 C \\\\nATOM 2431 C ALA A 305 -4.061 7.952 -4.097 1.00 98.57 C \\\\nATOM 2432 CB ALA A 305 -3.307 6.433 -5.966 1.00 98.57 C \\\\nATOM 2433 O ALA A 305 -4.728 8.836 -4.629 1.00 98.57 O \\\\nATOM 2434 N GLU A 306 -3.273 8.188 -3.053 1.00 98.38 N \\\\nATOM 2435 CA GLU A 306 -3.106 9.485 -2.395 1.00 98.38 C \\\\nATOM 2436 C GLU A 306 -1.620 9.847 -2.324 1.00 98.38 C \\\\nATOM 2437 CB GLU A 306 -3.768 9.411 -1.014 1.00 98.38 C \\\\nATOM 2438 O GLU A 306 -0.812 9.109 -1.754 1.00 98.38 O \\\\nATOM 2439 CG GLU A 306 -3.686 10.690 -0.165 1.00 98.38 C \\\\nATOM 2440 CD GLU A 306 -4.307 10.462 1.224 1.00 98.38 C \\\\nATOM 2441 OE1 GLU A 306 -3.891 11.102 2.218 1.00 98.38 O \\\\nATOM 2442 OE2 GLU A 306 -5.160 9.553 1.396 1.00 98.38 O \\\\nATOM 2443 N CYS A 307 -1.250 10.987 -2.907 1.00 98.55 N \\\\nATOM 2444 CA CYS A 307 0.134 11.440 -2.960 1.00 98.55 C \\\\nATOM 2445 C CYS A 307 0.551 12.019 -1.602 1.00 98.55 C \\\\nATOM 2446 CB CYS A 307 0.277 12.448 -4.103 1.00 98.55 C \\\\nATOM 2447 O CYS A 307 0.202 13.148 -1.256 1.00 98.55 O \\\\nATOM 2448 SG CYS A 307 2.033 12.800 -4.388 1.00 98.55 S \\\\nATOM 2449 N LEU A 308 1.309 11.243 -0.824 1.00 98.21 N \\\\nATOM 2450 CA LEU A 308 1.869 11.676 0.458 1.00 98.21 C \\\\nATOM 2451 C LEU A 308 3.240 12.351 0.316 1.00 98.21 C \\\\nATOM 2452 CB LEU A 308 1.971 10.471 1.404 1.00 98.21 C \\\\nATOM 2453 O LEU A 308 3.667 13.040 1.247 1.00 98.21 O \\\\nATOM 2454 CG LEU A 308 0.651 9.781 1.786 1.00 98.21 C \\\\nATOM 2455 CD1 LEU A 308 0.945 8.821 2.942 1.00 98.21 C \\\\nATOM 2456 CD2 LEU A 308 -0.428 10.758 2.256 1.00 98.21 C \\\\nATOM 2457 N SER A 309 3.918 12.113 -0.808 1.00 98.38 N \\\\nATOM 2458 CA SER A 309 5.160 12.764 -1.220 1.00 98.38 C \\\\nATOM 2459 C SER A 309 4.962 14.255 -1.504 1.00 98.38 C \\\\nATOM 2460 CB SER A 309 5.692 12.085 -2.486 1.00 98.38 C \\\\nATOM 2461 O SER A 309 3.910 14.669 -1.993 1.00 98.38 O \\\\nATOM 2462 OG SER A 309 6.949 12.629 -2.837 1.00 98.38 O \\\\nATOM 2463 N ASP A 310 6.018 15.035 -1.266 1.00 98.37 N \\\\nATOM 2464 CA ASP A 310 6.132 16.441 -1.669 1.00 98.37 C \\\\nATOM 2465 C ASP A 310 6.377 16.594 -3.189 1.00 98.37 C \\\\nATOM 2466 CB ASP A 310 7.257 17.105 -0.855 1.00 98.37 C \\\\nATOM 2467 O ASP A 310 6.329 17.696 -3.731 1.00 98.37 O \\\\nATOM 2468 CG ASP A 310 7.108 16.885 0.657 1.00 98.37 C \\\\nATOM 2469 OD1 ASP A 310 6.020 17.183 1.199 1.00 98.37 O \\\\nATOM 2470 OD2 ASP A 310 8.070 16.356 1.258 1.00 98.37 O \\\\nATOM 2471 N SER A 311 6.618 15.485 -3.899 1.00 98.40 N \\\\nATOM 2472 CA SER A 311 6.662 15.398 -5.363 1.00 98.40 C \\\\nATOM 2473 C SER A 311 5.446 14.649 -5.905 1.00 98.40 C \\\\nATOM 2474 CB SER A 311 7.935 14.680 -5.804 1.00 98.40 C \\\\nATOM 2475 O SER A 311 5.000 13.672 -5.314 1.00 98.40 O \\\\nATOM 2476 OG SER A 311 9.054 15.498 -5.541 1.00 98.40 O \\\\nATOM 2477 N ALA A 312 4.929 15.070 -7.062 1.00 98.66 N \\\\nATOM 2478 CA ALA A 312 3.782 14.415 -7.693 1.00 98.66 C \\\\nATOM 2479 C ALA A 312 4.071 12.953 -8.088 1.00 98.66 C \\\\nATOM 2480 CB ALA A 312 3.342 15.240 -8.910 1.00 98.66 C \\\\nATOM 2481 O ALA A 312 5.201 12.598 -8.445 1.00 98.66 O \\\\nATOM 2482 N ILE A 313 3.015 12.141 -8.102 1.00 98.82 N \\\\nATOM 2483 CA ILE A 313 2.999 10.804 -8.707 1.00 98.82 C \\\\nATOM 2484 C ILE A 313 2.170 10.823 -9.996 1.00 98.82 C \\\\nATOM 2485 CB ILE A 313 2.538 9.719 -7.707 1.00 98.82 C \\\\nATOM 2486 O ILE A 313 1.347 11.714 -10.212 1.00 98.82 O \\\\nATOM 2487 CG1 ILE A 313 1.073 9.935 -7.277 1.00 98.82 C \\\\nATOM 2488 CG2 ILE A 313 3.504 9.665 -6.509 1.00 98.82 C \\\\nATOM 2489 CD1 ILE A 313 0.539 8.921 -6.265 1.00 98.82 C \\\\nATOM 2490 N PHE A 314 2.401 9.848 -10.865 1.00 98.73 N \\\\nATOM 2491 CA PHE A 314 1.799 9.763 -12.195 1.00 98.73 C \\\\nATOM 2492 C PHE A 314 1.232 8.361 -12.370 1.00 98.73 C \\\\nATOM 2493 CB PHE A 314 2.873 10.087 -13.242 1.00 98.73 C \\\\nATOM 2494 O PHE A 314 1.959 7.403 -12.131 1.00 98.73 O \\\\nATOM 2495 CG PHE A 314 3.483 11.464 -13.086 1.00 98.73 C \\\\nATOM 2496 CD1 PHE A 314 2.991 12.550 -13.832 1.00 98.73 C \\\\nATOM 2497 CD2 PHE A 314 4.534 11.664 -12.170 1.00 98.73 C \\\\nATOM 2498 CE1 PHE A 314 3.556 13.826 -13.660 1.00 98.73 C \\\\nATOM 2499 CE2 PHE A 314 5.066 12.949 -11.972 1.00 98.73 C \\\\nATOM 2500 CZ PHE A 314 4.588 14.029 -12.729 1.00 98.73 C \\\\nATOM 2501 N VAL A 315 -0.044 8.232 -12.728 1.00 98.59 N \\\\nATOM 2502 CA VAL A 315 -0.794 6.970 -12.686 1.00 98.59 C \\\\nATOM 2503 C VAL A 315 -1.401 6.660 -14.047 1.00 98.59 C \\\\nATOM 2504 CB VAL A 315 -1.905 7.017 -11.616 1.00 98.59 C \\\\nATOM 2505 O VAL A 315 -2.157 7.463 -14.581 1.00 98.59 O \\\\nATOM 2506 CG1 VAL A 315 -2.648 5.676 -11.526 1.00 98.59 C \\\\nATOM 2507 CG2 VAL A 315 -1.334 7.361 -10.232 1.00 98.59 C \\\\nATOM 2508 N GLN A 316 -1.131 5.467 -14.567 1.00 98.50 N \\\\nATOM 2509 CA GLN A 316 -1.849 4.879 -15.694 1.00 98.50 C \\\\nATOM 2510 C GLN A 316 -2.736 3.760 -15.142 1.00 98.50 C \\\\nATOM 2511 CB GLN A 316 -0.823 4.384 -16.721 1.00 98.50 C \\\\nATOM 2512 O GLN A 316 -2.234 2.719 -14.716 1.00 98.50 O \\\\nATOM 2513 CG GLN A 316 -1.429 3.791 -17.999 1.00 98.50 C \\\\nATOM 2514 CD GLN A 316 -0.336 3.221 -18.902 1.00 98.50 C \\\\nATOM 2515 NE2 GLN A 316 -0.040 3.836 -20.027 1.00 98.50 N \\\\nATOM 2516 OE1 GLN A 316 0.309 2.230 -18.589 1.00 98.50 O \\\\nATOM 2517 N SER A 317 -4.049 3.996 -15.117 1.00 98.39 N \\\\nATOM 2518 CA SER A 317 -5.060 2.984 -14.795 1.00 98.39 C \\\\nATOM 2519 C SER A 317 -6.089 2.946 -15.923 1.00 98.39 C \\\\nATOM 2520 CB SER A 317 -5.762 3.277 -13.467 1.00 98.39 C \\\\nATOM 2521 O SER A 317 -6.858 3.903 -16.054 1.00 98.39 O \\\\nATOM 2522 OG SER A 317 -6.874 2.408 -13.353 1.00 98.39 O \\\\nATOM 2523 N PRO A 318 -6.152 1.862 -16.715 1.00 97.77 N \\\\nATOM 2524 CA PRO A 318 -7.133 1.740 -17.789 1.00 97.77 C \\\\nATOM 2525 C PRO A 318 -8.589 1.853 -17.303 1.00 97.77 C \\\\nATOM 2526 CB PRO A 318 -6.821 0.396 -18.446 1.00 97.77 C \\\\nATOM 2527 O PRO A 318 -9.390 2.516 -17.953 1.00 97.77 O \\\\nATOM 2528 CG PRO A 318 -5.322 0.232 -18.214 1.00 97.77 C \\\\nATOM 2529 CD PRO A 318 -5.171 0.786 -16.801 1.00 97.77 C \\\\nATOM 2530 N ASN A 319 -8.918 1.326 -16.113 1.00 97.99 N \\\\nATOM 2531 CA ASN A 319 -10.244 1.493 -15.496 1.00 97.99 C \\\\nATOM 2532 C ASN A 319 -10.566 2.966 -15.183 1.00 97.99 C \\\\nATOM 2533 CB ASN A 319 -10.309 0.611 -14.236 1.00 97.99 C \\\\nATOM 2534 O ASN A 319 -11.661 3.438 -15.478 1.00 97.99 O \\\\nATOM 2535 CG ASN A 319 -11.614 0.775 -13.470 1.00 97.99 C \\\\nATOM 2536 ND2 ASN A 319 -12.663 0.081 -13.837 1.00 97.99 N \\\\nATOM 2537 OD1 ASN A 319 -11.698 1.547 -12.527 1.00 97.99 O \\\\nATOM 2538 N CYS A 320 -9.600 3.715 -14.641 1.00 97.61 N \\\\nATOM 2539 CA CYS A 320 -9.765 5.149 -14.404 1.00 97.61 C \\\\nATOM 2540 C CYS A 320 -9.915 5.926 -15.721 1.00 97.61 C \\\\nATOM 2541 CB CYS A 320 -8.560 5.644 -13.598 1.00 97.61 C \\\\nATOM 2542 O CYS A 320 -10.769 6.803 -15.818 1.00 97.61 O \\\\nATOM 2543 SG CYS A 320 -8.805 7.360 -13.069 1.00 97.61 S \\\\nATOM 2544 N ASN A 321 -9.107 5.597 -16.730 1.00 97.67 N \\\\nATOM 2545 CA ASN A 321 -9.126 6.263 -18.030 1.00 97.67 C \\\\nATOM 2546 C ASN A 321 -10.470 6.049 -18.742 1.00 97.67 C \\\\nATOM 2547 CB ASN A 321 -7.913 5.779 -18.849 1.00 97.67 C \\\\nATOM 2548 O ASN A 321 -11.088 7.022 -19.169 1.00 97.67 O \\\\nATOM 2549 CG ASN A 321 -6.587 6.264 -18.280 1.00 97.67 C \\\\nATOM 2550 ND2 ASN A 321 -5.481 5.659 -18.640 1.00 97.67 N \\\\nATOM 2551 OD1 ASN A 321 -6.511 7.213 -17.517 1.00 97.67 O \\\\nATOM 2552 N GLN A 322 -10.981 4.814 -18.757 1.00 96.68 N \\\\nATOM 2553 CA GLN A 322 -12.291 4.489 -19.322 1.00 96.68 C \\\\nATOM 2554 C GLN A 322 -13.438 5.228 -18.615 1.00 96.68 C \\\\nATOM 2555 CB GLN A 322 -12.479 2.967 -19.285 1.00 96.68 C \\\\nATOM 2556 O GLN A 322 -14.307 5.769 -19.296 1.00 96.68 O \\\\nATOM 2557 CG GLN A 322 -13.796 2.518 -19.940 1.00 96.68 C \\\\nATOM 2558 CD GLN A 322 -13.909 1.001 -20.053 1.00 96.68 C \\\\nATOM 2559 NE2 GLN A 322 -15.063 0.474 -20.393 1.00 96.68 N \\\\nATOM 2560 OE1 GLN A 322 -12.970 0.258 -19.833 1.00 96.68 O \\\\nATOM 2561 N ARG A 323 -13.426 5.330 -17.274 1.00 96.89 N \\\\nATOM 2562 CA ARG A 323 -14.443 6.083 -16.507 1.00 96.89 C \\\\nATOM 2563 C ARG A 323 -14.564 7.543 -16.958 1.00 96.89 C \\\\nATOM 2564 CB ARG A 323 -14.107 6.024 -15.006 1.00 96.89 C \\\\nATOM 2565 O ARG A 323 -15.663 8.090 -16.961 1.00 96.89 O \\\\nATOM 2566 CG ARG A 323 -15.199 6.657 -14.117 1.00 96.89 C \\\\nATOM 2567 CD ARG A 323 -14.716 6.904 -12.685 1.00 96.89 C \\\\nATOM 2568 NE ARG A 323 -14.325 5.643 -12.043 1.00 96.89 N \\\\nATOM 2569 NH1 ARG A 323 -12.182 6.137 -11.428 1.00 96.89 N \\\\nATOM 2570 NH2 ARG A 323 -12.918 4.017 -11.386 1.00 96.89 N \\\\nATOM 2571 CZ ARG A 323 -13.140 5.272 -11.615 1.00 96.89 C \\\\nATOM 2572 N TYR A 324 -13.446 8.175 -17.312 1.00 96.60 N \\\\nATOM 2573 CA TYR A 324 -13.397 9.579 -17.733 1.00 96.60 C \\\\nATOM 2574 C TYR A 324 -13.390 9.773 -19.261 1.00 96.60 C \\\\nATOM 2575 CB TYR A 324 -12.221 10.278 -17.032 1.00 96.60 C \\\\nATOM 2576 O TYR A 324 -13.228 10.900 -19.721 1.00 96.60 O \\\\nATOM 2577 CG TYR A 324 -12.352 10.360 -15.519 1.00 96.60 C \\\\nATOM 2578 CD1 TYR A 324 -13.401 11.106 -14.946 1.00 96.60 C \\\\nATOM 2579 CD2 TYR A 324 -11.424 9.710 -14.684 1.00 96.60 C \\\\nATOM 2580 CE1 TYR A 324 -13.535 11.186 -13.547 1.00 96.60 C \\\\nATOM 2581 CE2 TYR A 324 -11.555 9.779 -13.283 1.00 96.60 C \\\\nATOM 2582 OH TYR A 324 -12.750 10.575 -11.362 1.00 96.60 O \\\\nATOM 2583 CZ TYR A 324 -12.613 10.515 -12.714 1.00 96.60 C \\\\nATOM 2584 N GLY A 325 -13.566 8.706 -20.052 1.00 96.83 N \\\\nATOM 2585 CA GLY A 325 -13.546 8.778 -21.518 1.00 96.83 C \\\\nATOM 2586 C GLY A 325 -12.171 9.110 -22.114 1.00 96.83 C \\\\nATOM 2587 O GLY A 325 -12.085 9.595 -23.239 1.00 96.83 O \\\\nATOM 2588 N TRP A 326 -11.088 8.885 -21.368 1.00 96.86 N \\\\nATOM 2589 CA TRP A 326 -9.719 9.104 -21.832 1.00 96.86 C \\\\nATOM 2590 C TRP A 326 -9.160 7.863 -22.529 1.00 96.86 C \\\\nATOM 2591 CB TRP A 326 -8.824 9.520 -20.657 1.00 96.86 C \\\\nATOM 2592 O TRP A 326 -9.530 6.733 -22.211 1.00 96.86 O \\\\nATOM 2593 CG TRP A 326 -9.208 10.774 -19.932 1.00 96.86 C \\\\nATOM 2594 CD1 TRP A 326 -9.869 11.827 -20.467 1.00 96.86 C \\\\nATOM 2595 CD2 TRP A 326 -9.012 11.108 -18.521 1.00 96.86 C \\\\nATOM 2596 CE2 TRP A 326 -9.585 12.393 -18.279 1.00 96.86 C \\\\nATOM 2597 CE3 TRP A 326 -8.445 10.441 -17.410 1.00 96.86 C \\\\nATOM 2598 NE1 TRP A 326 -10.085 12.785 -19.500 1.00 96.86 N \\\\nATOM 2599 CH2 TRP A 326 -9.046 12.288 -15.922 1.00 96.86 C \\\\nATOM 2600 CZ2 TRP A 326 -9.597 12.988 -17.008 1.00 96.86 C \\\\nATOM 2601 CZ3 TRP A 326 -8.480 11.017 -16.125 1.00 96.86 C \\\\nATOM 2602 N HIS A 327 -8.192 8.071 -23.429 1.00 96.47 N \\\\nATOM 2603 CA HIS A 327 -7.456 6.975 -24.059 1.00 96.47 C \\\\nATOM 2604 C HIS A 327 -6.885 6.008 -22.993 1.00 96.47 C \\\\nATOM 2605 CB HIS A 327 -6.341 7.555 -24.942 1.00 96.47 C \\\\nATOM 2606 O HIS A 327 -6.330 6.481 -21.996 1.00 96.47 O \\\\nATOM 2607 CG HIS A 327 -5.666 6.498 -25.775 1.00 96.47 C \\\\nATOM 2608 CD2 HIS A 327 -6.181 5.901 -26.894 1.00 96.47 C \\\\nATOM 2609 ND1 HIS A 327 -4.451 5.902 -25.523 1.00 96.47 N \\\\nATOM 2610 CE1 HIS A 327 -4.247 4.955 -26.458 1.00 96.47 C \\\\nATOM 2611 NE2 HIS A 327 -5.285 4.912 -27.299 1.00 96.47 N \\\\nATOM 2612 N PRO A 328 -6.948 4.670 -23.168 1.00 94.55 N \\\\nATOM 2613 CA PRO A 328 -6.511 3.714 -22.142 1.00 94.55 C \\\\nATOM 2614 C PRO A 328 -5.063 3.912 -21.667 1.00 94.55 C \\\\nATOM 2615 CB PRO A 328 -6.707 2.331 -22.770 1.00 94.55 C \\\\nATOM 2616 O PRO A 328 -4.744 3.622 -20.514 1.00 94.55 O \\\\nATOM 2617 CG PRO A 328 -7.873 2.550 -23.731 1.00 94.55 C \\\\nATOM 2618 CD PRO A 328 -7.614 3.961 -24.254 1.00 94.55 C \\\\nATOM 2619 N ALA A 329 -4.203 4.470 -22.525 1.00 95.38 N \\\\nATOM 2620 CA ALA A 329 -2.805 4.780 -22.223 1.00 95.38 C \\\\nATOM 2621 C ALA A 329 -2.573 6.023 -21.339 1.00 95.38 C \\\\nATOM 2622 CB ALA A 329 -2.057 4.963 -23.546 1.00 95.38 C \\\\nATOM 2623 O ALA A 329 -1.431 6.232 -20.922 1.00 95.38 O \\\\nATOM 2624 N THR A 330 -3.592 6.859 -21.101 1.00 97.03 N \\\\nATOM 2625 CA THR A 330 -3.469 8.168 -20.437 1.00 97.03 C \\\\nATOM 2626 C THR A 330 -2.818 8.070 -19.056 1.00 97.03 C \\\\nATOM 2627 CB THR A 330 -4.839 8.868 -20.371 1.00 97.03 C \\\\nATOM 2628 O THR A 330 -3.058 7.131 -18.293 1.00 97.03 O \\\\nATOM 2629 CG2 THR A 330 -4.888 10.148 -19.534 1.00 97.03 C \\\\nATOM 2630 OG1 THR A 330 -5.162 9.258 -21.682 1.00 97.03 O \\\\nATOM 2631 N VAL A 331 -1.977 9.059 -18.743 1.00 98.32 N \\\\nATOM 2632 CA VAL A 331 -1.197 9.127 -17.503 1.00 98.32 C \\\\nATOM 2633 C VAL A 331 -1.662 10.319 -16.667 1.00 98.32 C \\\\nATOM 2634 CB VAL A 331 0.314 9.177 -17.801 1.00 98.32 C \\\\nATOM 2635 O VAL A 331 -1.331 11.473 -16.939 1.00 98.32 O \\\\nATOM 2636 CG1 VAL A 331 1.119 9.167 -16.496 1.00 98.32 C \\\\nATOM 2637 CG2 VAL A 331 0.754 7.971 -18.641 1.00 98.32 C \\\\nATOM 2638 N CYS A 332 -2.424 10.038 -15.616 1.00 97.93 N \\\\nATOM 2639 CA CYS A 332 -2.985 11.032 -14.711 1.00 97.93 C \\\\nATOM 2640 C CYS A 332 -1.943 11.484 -13.678 1.00 97.93 C \\\\nATOM 2641 CB CYS A 332 -4.212 10.433 -14.013 1.00 97.93 C \\\\nATOM 2642 O CYS A 332 -1.425 10.677 -12.904 1.00 97.93 O \\\\nATOM 2643 SG CYS A 332 -5.401 9.801 -15.228 1.00 97.93 S \\\\nATOM 2644 N LYS A 333 -1.662 12.786 -13.603 1.00 98.40 N \\\\nATOM 2645 CA LYS A 333 -0.823 13.367 -12.544 1.00 98.40 C \\\\nATOM 2646 C LYS A 333 -1.639 13.558 -11.262 1.00 98.40 C \\\\nATOM 2647 CB LYS A 333 -0.231 14.684 -13.062 1.00 98.40 C \\\\nATOM 2648 O LYS A 333 -2.661 14.236 -11.287 1.00 98.40 O \\\\nATOM 2649 CG LYS A 333 0.684 15.383 -12.046 1.00 98.40 C \\\\nATOM 2650 CD LYS A 333 1.203 16.686 -12.664 1.00 98.40 C \\\\nATOM 2651 CE LYS A 333 2.105 17.450 -11.694 1.00 98.40 C \\\\nATOM 2652 NZ LYS A 333 2.527 18.742 -12.291 1.00 98.40 N \\\\nATOM 2653 N ILE A 334 -1.145 13.050 -10.134 1.00 98.51 N \\\\nATOM 2654 CA ILE A 334 -1.685 13.314 -8.792 1.00 98.51 C \\\\nATOM 2655 C ILE A 334 -0.687 14.224 -8.050 1.00 98.51 C \\\\nATOM 2656 CB ILE A 334 -1.975 12.007 -8.019 1.00 98.51 C \\\\nATOM 2657 O ILE A 334 0.409 13.772 -7.703 1.00 98.51 O \\\\nATOM 2658 CG1 ILE A 334 -2.838 11.022 -8.842 1.00 98.51 C \\\\nATOM 2659 CG2 ILE A 334 -2.655 12.336 -6.674 1.00 98.51 C \\\\nATOM 2660 CD1 ILE A 334 -3.066 9.673 -8.151 1.00 98.51 C \\\\nATOM 2661 N PRO A 335 -1.013 15.514 -7.831 1.00 98.57 N \\\\nATOM 2662 CA PRO A 335 -0.159 16.433 -7.078 1.00 98.57 C \\\\nATOM 2663 C PRO A 335 -0.027 16.061 -5.586 1.00 98.57 C \\\\nATOM 2664 CB PRO A 335 -0.788 17.823 -7.244 1.00 98.57 C \\\\nATOM 2665 O PRO A 335 -0.885 15.351 -5.057 1.00 98.57 O \\\\nATOM 2666 CG PRO A 335 -1.649 17.696 -8.499 1.00 98.57 C \\\\nATOM 2667 CD PRO A 335 -2.117 16.247 -8.435 1.00 98.57 C \\\\nATOM 2668 N PRO A 336 0.997 16.579 -4.880 1.00 98.51 N \\\\nATOM 2669 CA PRO A 336 1.147 16.432 -3.429 1.00 98.51 C \\\\nATOM 2670 C PRO A 336 -0.131 16.770 -2.651 1.00 98.51 C \\\\nATOM 2671 CB PRO A 336 2.291 17.377 -3.044 1.00 98.51 C \\\\nATOM 2672 O PRO A 336 -0.737 17.819 -2.856 1.00 98.51 O \\\\nATOM 2673 CG PRO A 336 3.155 17.374 -4.300 1.00 98.51 C \\\\nATOM 2674 CD PRO A 336 2.115 17.342 -5.414 1.00 98.51 C \\\\nATOM 2675 N GLY A 337 -0.549 15.876 -1.752 1.00 95.96 N \\\\nATOM 2676 CA GLY A 337 -1.767 16.020 -0.948 1.00 95.96 C \\\\nATOM 2677 C GLY A 337 -3.084 15.715 -1.678 1.00 95.96 C \\\\nATOM 2678 O GLY A 337 -4.129 15.661 -1.028 1.00 95.96 O \\\\nATOM 2679 N CYS A 338 -3.066 15.485 -2.994 1.00 97.97 N \\\\nATOM 2680 CA CYS A 338 -4.239 15.055 -3.755 1.00 97.97 C \\\\nATOM 2681 C CYS A 338 -4.426 13.529 -3.706 1.00 97.97 C \\\\nATOM 2682 CB CYS A 338 -4.149 15.568 -5.200 1.00 97.97 C \\\\nATOM 2683 O CYS A 338 -3.501 12.769 -3.408 1.00 97.97 O \\\\nATOM 2684 SG CYS A 338 -4.101 17.385 -5.234 1.00 97.97 S \\\\nATOM 2685 N ASN A 339 -5.636 13.079 -4.040 1.00 97.19 N \\\\nATOM 2686 CA ASN A 339 -5.968 11.670 -4.234 1.00 97.19 C \\\\nATOM 2687 C ASN A 339 -6.816 11.470 -5.499 1.00 97.19 C \\\\nATOM 2688 CB ASN A 339 -6.641 11.094 -2.973 1.00 97.19 C \\\\nATOM 2689 O ASN A 339 -7.424 12.420 -5.991 1.00 97.19 O \\\\nATOM 2690 CG ASN A 339 -8.006 11.697 -2.697 1.00 97.19 C \\\\nATOM 2691 ND2 ASN A 339 -8.068 12.787 -1.966 1.00 97.19 N \\\\nATOM 2692 OD1 ASN A 339 -9.032 11.213 -3.137 1.00 97.19 O \\\\nATOM 2693 N LEU A 340 -6.834 10.241 -6.013 1.00 97.74 N \\\\nATOM 2694 CA LEU A 340 -7.588 9.821 -7.194 1.00 97.74 C \\\\nATOM 2695 C LEU A 340 -8.170 8.421 -6.967 1.00 97.74 C \\\\nATOM 2696 CB LEU A 340 -6.636 9.839 -8.406 1.00 97.74 C \\\\nATOM 2697 O LEU A 340 -7.485 7.548 -6.431 1.00 97.74 O \\\\nATOM 2698 CG LEU A 340 -7.252 9.450 -9.765 1.00 97.74 C \\\\nATOM 2699 CD1 LEU A 340 -8.359 10.414 -10.195 1.00 97.74 C \\\\nATOM 2700 CD2 LEU A 340 -6.159 9.459 -10.835 1.00 97.74 C \\\\nATOM 2701 N LYS A 341 -9.407 8.188 -7.420 1.00 97.97 N \\\\nATOM 2702 CA LYS A 341 -10.010 6.849 -7.498 1.00 97.97 C \\\\nATOM 2703 C LYS A 341 -9.441 6.115 -8.710 1.00 97.97 C \\\\nATOM 2704 CB LYS A 341 -11.538 6.971 -7.566 1.00 97.97 C \\\\nATOM 2705 O LYS A 341 -9.873 6.340 -9.838 1.00 97.97 O \\\\nATOM 2706 CG LYS A 341 -12.210 5.588 -7.497 1.00 97.97 C \\\\nATOM 2707 CD LYS A 341 -13.726 5.666 -7.704 1.00 97.97 C \\\\nATOM 2708 CE LYS A 341 -14.397 6.548 -6.645 1.00 97.97 C \\\\nATOM 2709 NZ LYS A 341 -15.870 6.475 -6.744 1.00 97.97 N \\\\nATOM 2710 N ILE A 342 -8.457 5.254 -8.483 1.00 98.34 N \\\\nATOM 2711 CA ILE A 342 -7.732 4.562 -9.552 1.00 98.34 C \\\\nATOM 2712 C ILE A 342 -8.460 3.309 -10.050 1.00 98.34 C \\\\nATOM 2713 CB ILE A 342 -6.280 4.249 -9.132 1.00 98.34 C \\\\nATOM 2714 O ILE A 342 -8.189 2.889 -11.168 1.00 98.34 O \\\\nATOM 2715 CG1 ILE A 342 -6.231 3.224 -7.976 1.00 98.34 C \\\\nATOM 2716 CG2 ILE A 342 -5.535 5.553 -8.793 1.00 98.34 C \\\\nATOM 2717 CD1 ILE A 342 -4.827 2.765 -7.596 1.00 98.34 C \\\\nATOM 2718 N PHE A 343 -9.368 2.720 -9.264 1.00 98.38 N \\\\nATOM 2719 CA PHE A 343 -10.139 1.539 -9.668 1.00 98.38 C \\\\nATOM 2720 C PHE A 343 -11.522 1.488 -9.004 1.00 98.38 C \\\\nATOM 2721 CB PHE A 343 -9.354 0.262 -9.343 1.00 98.38 C \\\\nATOM 2722 O PHE A 343 -11.668 1.935 -7.865 1.00 98.38 O \\\\nATOM 2723 CG PHE A 343 -9.807 -0.946 -10.137 1.00 98.38 C \\\\nATOM 2724 CD1 PHE A 343 -10.721 -1.865 -9.586 1.00 98.38 C \\\\nATOM 2725 CD2 PHE A 343 -9.294 -1.165 -11.430 1.00 98.38 C \\\\nATOM 2726 CE1 PHE A 343 -11.108 -2.997 -10.323 1.00 98.38 C \\\\nATOM 2727 CE2 PHE A 343 -9.684 -2.301 -12.160 1.00 98.38 C \\\\nATOM 2728 CZ PHE A 343 -10.580 -3.224 -11.602 1.00 98.38 C \\\\nATOM 2729 N ASN A 344 -12.511 0.898 -9.675 1.00 96.95 N \\\\nATOM 2730 CA ASN A 344 -13.810 0.538 -9.101 1.00 96.95 C \\\\nATOM 2731 C ASN A 344 -14.249 -0.852 -9.617 1.00 96.95 C \\\\nATOM 2732 CB ASN A 344 -14.811 1.671 -9.406 1.00 96.95 C \\\\nATOM 2733 O ASN A 344 -14.299 -1.098 -10.824 1.00 96.95 O \\\\nATOM 2734 CG ASN A 344 -16.252 1.329 -9.067 1.00 96.95 C \\\\nATOM 2735 ND2 ASN A 344 -16.917 2.009 -8.169 1.00 96.95 N \\\\nATOM 2736 OD1 ASN A 344 -16.815 0.393 -9.597 1.00 96.95 O \\\\nATOM 2737 N ASN A 345 -14.585 -1.756 -8.691 1.00 95.65 N \\\\nATOM 2738 CA ASN A 345 -14.955 -3.140 -8.994 1.00 95.65 C \\\\nATOM 2739 C ASN A 345 -16.313 -3.279 -9.705 1.00 95.65 C \\\\nATOM 2740 CB ASN A 345 -14.978 -3.970 -7.695 1.00 95.65 C \\\\nATOM 2741 O ASN A 345 -16.496 -4.245 -10.438 1.00 95.65 O \\\\nATOM 2742 CG ASN A 345 -13.622 -4.311 -7.098 1.00 95.65 C \\\\nATOM 2743 ND2 ASN A 345 -13.616 -5.022 -5.996 1.00 95.65 N \\\\nATOM 2744 OD1 ASN A 345 -12.567 -3.976 -7.606 1.00 95.65 O \\\\nATOM 2745 N GLN A 346 -17.266 -2.360 -9.509 1.00 95.14 N \\\\nATOM 2746 CA GLN A 346 -18.570 -2.389 -10.192 1.00 95.14 C \\\\nATOM 2747 C GLN A 346 -18.434 -2.020 -11.675 1.00 95.14 C \\\\nATOM 2748 CB GLN A 346 -19.572 -1.432 -9.520 1.00 95.14 C \\\\nATOM 2749 O GLN A 346 -19.045 -2.656 -12.528 1.00 95.14 O \\\\nATOM 2750 CG GLN A 346 -19.850 -1.744 -8.045 1.00 95.14 C \\\\nATOM 2751 CD GLN A 346 -20.867 -0.771 -7.458 1.00 95.14 C \\\\nATOM 2752 NE2 GLN A 346 -21.978 -1.246 -6.939 1.00 95.14 N \\\\nATOM 2753 OE1 GLN A 346 -20.692 0.434 -7.453 1.00 95.14 O \\\\nATOM 2754 N GLU A 347 -17.593 -1.034 -11.990 1.00 95.97 N \\\\nATOM 2755 CA GLU A 347 -17.256 -0.657 -13.367 1.00 95.97 C \\\\nATOM 2756 C GLU A 347 -16.535 -1.805 -14.087 1.00 95.97 C \\\\nATOM 2757 CB GLU A 347 -16.368 0.596 -13.346 1.00 95.97 C \\\\nATOM 2758 O GLU A 347 -16.882 -2.144 -15.217 1.00 95.97 O \\\\nATOM 2759 CG GLU A 347 -17.108 1.858 -12.867 1.00 95.97 C \\\\nATOM 2760 CD GLU A 347 -16.146 3.008 -12.540 1.00 95.97 C \\\\nATOM 2761 OE1 GLU A 347 -16.567 4.018 -11.935 1.00 95.97 O \\\\nATOM 2762 OE2 GLU A 347 -14.927 2.898 -12.799 1.00 95.97 O \\\\nATOM 2763 N PHE A 348 -15.586 -2.464 -13.409 1.00 97.03 N \\\\nATOM 2764 CA PHE A 348 -14.939 -3.667 -13.936 1.00 97.03 C \\\\nATOM 2765 C PHE A 348 -15.919 -4.841 -14.102 1.00 97.03 C \\\\nATOM 2766 CB PHE A 348 -13.752 -4.044 -13.043 1.00 97.03 C \\\\nATOM 2767 O PHE A 348 -15.876 -5.515 -15.126 1.00 97.03 O \\\\nATOM 2768 CG PHE A 348 -13.012 -5.279 -13.524 1.00 97.03 C \\\\nATOM 2769 CD1 PHE A 348 -13.244 -6.527 -12.912 1.00 97.03 C \\\\nATOM 2770 CD2 PHE A 348 -12.127 -5.191 -14.616 1.00 97.03 C \\\\nATOM 2771 CE1 PHE A 348 -12.591 -7.679 -13.387 1.00 97.03 C \\\\nATOM 2772 CE2 PHE A 348 -11.474 -6.344 -15.089 1.00 97.03 C \\\\nATOM 2773 CZ PHE A 348 -11.706 -7.586 -14.474 1.00 97.03 C \\\\nATOM 2774 N ALA A 349 -16.836 -5.061 -13.151 1.00 95.38 N \\\\nATOM 2775 CA ALA A 349 -17.877 -6.089 -13.243 1.00 95.38 C \\\\nATOM 2776 C ALA A 349 -18.769 -5.904 -14.478 1.00 95.38 C \\\\nATOM 2777 CB ALA A 349 -18.758 -6.034 -11.985 1.00 95.38 C \\\\nATOM 2778 O ALA A 349 -19.033 -6.861 -15.205 1.00 95.38 O \\\\nATOM 2779 N ALA A 350 -19.224 -4.669 -14.713 1.00 95.44 N \\\\nATOM 2780 CA ALA A 350 -20.069 -4.329 -15.850 1.00 95.44 C \\\\nATOM 2781 C ALA A 350 -19.336 -4.555 -17.180 1.00 95.44 C \\\\nATOM 2782 CB ALA A 350 -20.535 -2.877 -15.689 1.00 95.44 C \\\\nATOM 2783 O ALA A 350 -19.901 -5.157 -18.091 1.00 95.44 O \\\\nATOM 2784 N LEU A 351 -18.068 -4.140 -17.268 1.00 95.45 N \\\\nATOM 2785 CA LEU A 351 -17.235 -4.369 -18.446 1.00 95.45 C \\\\nATOM 2786 C LEU A 351 -16.982 -5.863 -18.691 1.00 95.45 C \\\\nATOM 2787 CB LEU A 351 -15.927 -3.589 -18.264 1.00 95.45 C \\\\nATOM 2788 O LEU A 351 -17.164 -6.335 -19.808 1.00 95.45 O \\\\nATOM 2789 CG LEU A 351 -14.970 -3.702 -19.462 1.00 95.45 C \\\\nATOM 2790 CD1 LEU A 351 -15.584 -3.164 -20.755 1.00 95.45 C \\\\nATOM 2791 CD2 LEU A 351 -13.718 -2.901 -19.127 1.00 95.45 C \\\\nATOM 2792 N LEU A 352 -16.637 -6.626 -17.649 1.00 96.13 N \\\\nATOM 2793 CA LEU A 352 -16.427 -8.072 -17.739 1.00 96.13 C \\\\nATOM 2794 C LEU A 352 -17.687 -8.794 -18.240 1.00 96.13 C \\\\nATOM 2795 CB LEU A 352 -15.943 -8.577 -16.365 1.00 96.13 C \\\\nATOM 2796 O LEU A 352 -17.603 -9.603 -19.160 1.00 96.13 O \\\\nATOM 2797 CG LEU A 352 -15.683 -10.092 -16.272 1.00 96.13 C \\\\nATOM 2798 CD1 LEU A 352 -14.689 -10.587 -17.318 1.00 96.13 C \\\\nATOM 2799 CD2 LEU A 352 -15.118 -10.422 -14.887 1.00 96.13 C \\\\nATOM 2800 N ALA A 353 -18.862 -8.453 -17.703 1.00 94.39 N \\\\nATOM 2801 CA ALA A 353 -20.137 -9.006 -18.157 1.00 94.39 C \\\\nATOM 2802 C ALA A 353 -20.473 -8.643 -19.618 1.00 94.39 C \\\\nATOM 2803 CB ALA A 353 -21.234 -8.528 -17.198 1.00 94.39 C \\\\nATOM 2804 O ALA A 353 -21.095 -9.440 -20.318 1.00 94.39 O \\\\nATOM 2805 N GLN A 354 -20.057 -7.466 -20.099 1.00 94.04 N \\\\nATOM 2806 CA GLN A 354 -20.220 -7.067 -21.500 1.00 94.04 C \\\\nATOM 2807 C GLN A 354 -19.262 -7.839 -22.420 1.00 94.04 C \\\\nATOM 2808 CB GLN A 354 -20.038 -5.547 -21.636 1.00 94.04 C \\\\nATOM 2809 O GLN A 354 -19.718 -8.442 -23.394 1.00 94.04 O \\\\nATOM 2810 CG GLN A 354 -21.235 -4.775 -21.055 1.00 94.04 C \\\\nATOM 2811 CD GLN A 354 -20.982 -3.275 -20.915 1.00 94.04 C \\\\nATOM 2812 NE2 GLN A 354 -21.886 -2.546 -20.298 1.00 94.04 N \\\\nATOM 2813 OE1 GLN A 354 -19.994 -2.713 -21.353 1.00 94.04 O \\\\nATOM 2814 N SER A 355 -17.968 -7.887 -22.088 1.00 94.46 N \\\\nATOM 2815 CA SER A 355 -16.929 -8.520 -22.912 1.00 94.46 C \\\\nATOM 2816 C SER A 355 -17.077 -10.034 -23.059 1.00 94.46 C \\\\nATOM 2817 CB SER A 355 -15.537 -8.197 -22.368 1.00 94.46 C \\\\nATOM 2818 O SER A 355 -16.649 -10.571 -24.074 1.00 94.46 O \\\\nATOM 2819 OG SER A 355 -15.291 -6.809 -22.469 1.00 94.46 O \\\\nATOM 2820 N VAL A 356 -17.745 -10.732 -22.131 1.00 92.71 N \\\\nATOM 2821 CA VAL A 356 -18.093 -12.160 -22.307 1.00 92.71 C \\\\nATOM 2822 C VAL A 356 -18.860 -12.407 -23.613 1.00 92.71 C \\\\nATOM 2823 CB VAL A 356 -18.887 -12.669 -21.087 1.00 92.71 C \\\\nATOM 2824 O VAL A 356 -18.597 -13.386 -24.306 1.00 92.71 O \\\\nATOM 2825 CG1 VAL A 356 -19.590 -14.012 -21.311 1.00 92.71 C \\\\nATOM 2826 CG2 VAL A 356 -17.941 -12.871 -19.900 1.00 92.71 C \\\\nATOM 2827 N ASN A 357 -19.745 -11.487 -24.013 1.00 89.37 N \\\\nATOM 2828 CA ASN A 357 -20.513 -11.601 -25.261 1.00 89.37 C \\\\nATOM 2829 C ASN A 357 -19.690 -11.255 -26.519 1.00 89.37 C \\\\nATOM 2830 CB ASN A 357 -21.776 -10.732 -25.163 1.00 89.37 C \\\\nATOM 2831 O ASN A 357 -20.150 -11.488 -27.633 1.00 89.37 O \\\\nATOM 2832 CG ASN A 357 -22.604 -11.057 -23.936 1.00 89.37 C \\\\nATOM 2833 ND2 ASN A 357 -22.554 -10.217 -22.930 1.00 89.37 N \\\\nATOM 2834 OD1 ASN A 357 -23.262 -12.078 -23.847 1.00 89.37 O \\\\nATOM 2835 N GLN A 358 -18.487 -10.699 -26.346 1.00 91.08 N \\\\nATOM 2836 CA GLN A 358 -17.529 -10.374 -27.411 1.00 91.08 C \\\\nATOM 2837 C GLN A 358 -16.492 -11.499 -27.621 1.00 91.08 C \\\\nATOM 2838 CB GLN A 358 -16.841 -9.038 -27.074 1.00 91.08 C \\\\nATOM 2839 O GLN A 358 -15.707 -11.448 -28.566 1.00 91.08 O \\\\nATOM 2840 CG GLN A 358 -17.800 -7.840 -26.950 1.00 91.08 C \\\\nATOM 2841 CD GLN A 358 -17.139 -6.596 -26.353 1.00 91.08 C \\\\nATOM 2842 NE2 GLN A 358 -17.807 -5.465 -26.381 1.00 91.08 N \\\\nATOM 2843 OE1 GLN A 358 -16.049 -6.607 -25.801 1.00 91.08 O \\\\nATOM 2844 N GLY A 359 -16.494 -12.529 -26.765 1.00 90.37 N \\\\nATOM 2845 CA GLY A 359 -15.665 -13.728 -26.894 1.00 90.37 C \\\\nATOM 2846 C GLY A 359 -14.324 -13.684 -26.151 1.00 90.37 C \\\\nATOM 2847 O GLY A 359 -14.008 -12.750 -25.412 1.00 90.37 O \\\\nATOM 2848 N PHE A 360 -13.531 -14.747 -26.339 1.00 90.85 N \\\\nATOM 2849 CA PHE A 360 -12.313 -15.020 -25.561 1.00 90.85 C \\\\nATOM 2850 C PHE A 360 -11.310 -13.865 -25.550 1.00 90.85 C \\\\nATOM 2851 CB PHE A 360 -11.668 -16.329 -26.041 1.00 90.85 C \\\\nATOM 2852 O PHE A 360 -10.863 -13.465 -24.477 1.00 90.85 O \\\\nATOM 2853 CG PHE A 360 -10.561 -16.809 -25.121 1.00 90.85 C \\\\nATOM 2854 CD1 PHE A 360 -9.265 -16.267 -25.227 1.00 90.85 C \\\\nATOM 2855 CD2 PHE A 360 -10.837 -17.763 -24.121 1.00 90.85 C \\\\nATOM 2856 CE1 PHE A 360 -8.253 -16.670 -24.338 1.00 90.85 C \\\\nATOM 2857 CE2 PHE A 360 -9.824 -18.168 -23.234 1.00 90.85 C \\\\nATOM 2858 CZ PHE A 360 -8.532 -17.623 -23.343 1.00 90.85 C \\\\nATOM 2859 N GLU A 361 -10.982 -13.310 -26.717 1.00 91.71 N \\\\nATOM 2860 CA GLU A 361 -9.951 -12.274 -26.825 1.00 91.71 C \\\\nATOM 2861 C GLU A 361 -10.351 -10.987 -26.091 1.00 91.71 C \\\\nATOM 2862 CB GLU A 361 -9.656 -12.018 -28.313 1.00 91.71 C \\\\nATOM 2863 O GLU A 361 -9.552 -10.427 -25.345 1.00 91.71 O \\\\nATOM 2864 CG GLU A 361 -8.429 -11.123 -28.545 1.00 91.71 C \\\\nATOM 2865 CD GLU A 361 -7.154 -11.667 -27.883 1.00 91.71 C \\\\nATOM 2866 OE1 GLU A 361 -6.342 -10.831 -27.422 1.00 91.71 O \\\\nATOM 2867 OE2 GLU A 361 -7.010 -12.908 -27.800 1.00 91.71 O \\\\nATOM 2868 N ALA A 362 -11.613 -10.562 -26.213 1.00 93.21 N \\\\nATOM 2869 CA ALA A 362 -12.117 -9.369 -25.538 1.00 93.21 C \\\\nATOM 2870 C ALA A 362 -11.999 -9.481 -24.010 1.00 93.21 C \\\\nATOM 2871 CB ALA A 362 -13.566 -9.150 -25.973 1.00 93.21 C \\\\nATOM 2872 O ALA A 362 -11.527 -8.553 -23.355 1.00 93.21 O \\\\nATOM 2873 N VAL A 363 -12.357 -10.639 -23.441 1.00 93.93 N \\\\nATOM 2874 CA VAL A 363 -12.168 -10.907 -22.007 1.00 93.93 C \\\\nATOM 2875 C VAL A 363 -10.682 -11.016 -21.660 1.00 93.93 C \\\\nATOM 2876 CB VAL A 363 -12.953 -12.156 -21.569 1.00 93.93 C \\\\nATOM 2877 O VAL A 363 -10.252 -10.433 -20.670 1.00 93.93 O \\\\nATOM 2878 CG1 VAL A 363 -12.751 -12.502 -20.091 1.00 93.93 C \\\\nATOM 2879 CG2 VAL A 363 -14.456 -11.915 -21.749 1.00 93.93 C \\\\nATOM 2880 N TYR A 364 -9.862 -11.685 -22.472 1.00 93.20 N \\\\nATOM 2881 CA TYR A 364 -8.427 -11.825 -22.207 1.00 93.20 C \\\\nATOM 2882 C TYR A 364 -7.715 -10.462 -22.122 1.00 93.20 C \\\\nATOM 2883 CB TYR A 364 -7.800 -12.732 -23.272 1.00 93.20 C \\\\nATOM 2884 O TYR A 364 -6.920 -10.228 -21.204 1.00 93.20 O \\\\nATOM 2885 CG TYR A 364 -6.345 -13.042 -22.995 1.00 93.20 C \\\\nATOM 2886 CD1 TYR A 364 -5.330 -12.355 -23.688 1.00 93.20 C \\\\nATOM 2887 CD2 TYR A 364 -6.013 -13.994 -22.012 1.00 93.20 C \\\\nATOM 2888 CE1 TYR A 364 -3.979 -12.605 -23.380 1.00 93.20 C \\\\nATOM 2889 CE2 TYR A 364 -4.663 -14.253 -21.707 1.00 93.20 C \\\\nATOM 2890 OH TYR A 364 -2.341 -13.787 -22.088 1.00 93.20 O \\\\nATOM 2891 CZ TYR A 364 -3.645 -13.550 -22.388 1.00 93.20 C \\\\nATOM 2892 N GLN A 365 -8.072 -9.512 -22.994 1.00 93.42 N \\\\nATOM 2893 CA GLN A 365 -7.553 -8.140 -22.965 1.00 93.42 C \\\\nATOM 2894 C GLN A 365 -7.907 -7.379 -21.672 1.00 93.42 C \\\\nATOM 2895 CB GLN A 365 -8.040 -7.370 -24.206 1.00 93.42 C \\\\nATOM 2896 O GLN A 365 -7.131 -6.515 -21.249 1.00 93.42 O \\\\nATOM 2897 CG GLN A 365 -7.428 -7.884 -25.524 1.00 93.42 C \\\\nATOM 2898 CD GLN A 365 -5.914 -7.725 -25.629 1.00 93.42 C \\\\nATOM 2899 NE2 GLN A 365 -5.257 -8.548 -26.410 1.00 93.42 N \\\\nATOM 2900 OE1 GLN A 365 -5.283 -6.872 -25.015 1.00 93.42 O \\\\nATOM 2901 N LEU A 366 -8.993 -7.738 -20.967 1.00 95.17 N \\\\nATOM 2902 CA LEU A 366 -9.334 -7.145 -19.664 1.00 95.17 C \\\\nATOM 2903 C LEU A 366 -8.290 -7.423 -18.574 1.00 95.17 C \\\\nATOM 2904 CB LEU A 366 -10.722 -7.583 -19.165 1.00 95.17 C \\\\nATOM 2905 O LEU A 366 -8.277 -6.712 -17.570 1.00 95.17 O \\\\nATOM 2906 CG LEU A 366 -11.909 -7.249 -20.080 1.00 95.17 C \\\\nATOM 2907 CD1 LEU A 366 -13.200 -7.665 -19.379 1.00 95.17 C \\\\nATOM 2908 CD2 LEU A 366 -11.996 -5.757 -20.398 1.00 95.17 C \\\\nATOM 2909 N THR A 367 -7.352 -8.355 -18.783 1.00 95.31 N \\\\nATOM 2910 CA THR A 367 -6.177 -8.527 -17.907 1.00 95.31 C \\\\nATOM 2911 C THR A 367 -5.436 -7.198 -17.716 1.00 95.31 C \\\\nATOM 2912 CB THR A 367 -5.206 -9.573 -18.482 1.00 95.31 C \\\\nATOM 2913 O THR A 367 -5.001 -6.880 -16.610 1.00 95.31 O \\\\nATOM 2914 CG2 THR A 367 -4.080 -9.922 -17.507 1.00 95.31 C \\\\nATOM 2915 OG1 THR A 367 -5.878 -10.777 -18.753 1.00 95.31 O \\\\nATOM 2916 N ARG A 368 -5.376 -6.362 -18.767 1.00 94.06 N \\\\nATOM 2917 CA ARG A 368 -4.761 -5.024 -18.728 1.00 94.06 C \\\\nATOM 2918 C ARG A 368 -5.491 -4.059 -17.790 1.00 94.06 C \\\\nATOM 2919 CB ARG A 368 -4.712 -4.429 -20.146 1.00 94.06 C \\\\nATOM 2920 O ARG A 368 -4.845 -3.193 -17.211 1.00 94.06 O \\\\nATOM 2921 CG ARG A 368 -3.878 -5.258 -21.138 1.00 94.06 C \\\\nATOM 2922 CD ARG A 368 -3.914 -4.608 -22.527 1.00 94.06 C \\\\nATOM 2923 NE ARG A 368 -3.118 -5.365 -23.510 1.00 94.06 N \\\\nATOM 2924 NH1 ARG A 368 -3.408 -3.937 -25.296 1.00 94.06 N \\\\nATOM 2925 NH2 ARG A 368 -2.269 -5.831 -25.575 1.00 94.06 N \\\\nATOM 2926 CZ ARG A 368 -2.938 -5.042 -24.782 1.00 94.06 C \\\\nATOM 2927 N MET A 369 -6.806 -4.208 -17.603 1.00 95.92 N \\\\nATOM 2928 CA MET A 369 -7.591 -3.369 -16.685 1.00 95.92 C \\\\nATOM 2929 C MET A 369 -7.190 -3.597 -15.226 1.00 95.92 C \\\\nATOM 2930 CB MET A 369 -9.098 -3.637 -16.840 1.00 95.92 C \\\\nATOM 2931 O MET A 369 -7.254 -2.670 -14.421 1.00 95.92 O \\\\nATOM 2932 CG MET A 369 -9.631 -3.405 -18.258 1.00 95.92 C \\\\nATOM 2933 SD MET A 369 -9.534 -1.698 -18.853 1.00 95.92 S \\\\nATOM 2934 CE MET A 369 -10.858 -0.933 -17.889 1.00 95.92 C \\\\nATOM 2935 N CYS A 370 -6.756 -4.814 -14.892 1.00 97.33 N \\\\nATOM 2936 CA CYS A 370 -6.361 -5.210 -13.542 1.00 97.33 C \\\\nATOM 2937 C CYS A 370 -4.930 -4.783 -13.163 1.00 97.33 C \\\\nATOM 2938 CB CYS A 370 -6.520 -6.726 -13.419 1.00 97.33 C \\\\nATOM 2939 O CYS A 370 -4.534 -4.961 -12.006 1.00 97.33 O \\\\nATOM 2940 SG CYS A 370 -8.188 -7.266 -13.897 1.00 97.33 S \\\\nATOM 2941 N THR A 371 -4.166 -4.227 -14.112 1.00 97.75 N \\\\nATOM 2942 CA THR A 371 -2.799 -3.731 -13.912 1.00 97.75 C \\\\nATOM 2943 C THR A 371 -2.781 -2.203 -13.909 1.00 97.75 C \\\\nATOM 2944 CB THR A 371 -1.831 -4.295 -14.965 1.00 97.75 C \\\\nATOM 2945 O THR A 371 -3.195 -1.556 -14.869 1.00 97.75 O \\\\nATOM 2946 CG2 THR A 371 -0.398 -3.796 -14.784 1.00 97.75 C \\\\nATOM 2947 OG1 THR A 371 -1.781 -5.699 -14.867 1.00 97.75 O \\\\nATOM 2948 N ILE A 372 -2.257 -1.608 -12.836 1.00 98.54 N \\\\nATOM 2949 CA ILE A 372 -2.121 -0.152 -12.686 1.00 98.54 C \\\\nATOM 2950 C ILE A 372 -0.647 0.191 -12.503 1.00 98.54 C \\\\nATOM 2951 CB ILE A 372 -2.996 0.374 -11.525 1.00 98.54 C \\\\nATOM 2952 O ILE A 372 0.026 -0.382 -11.648 1.00 98.54 O \\\\nATOM 2953 CG1 ILE A 372 -4.488 0.075 -11.799 1.00 98.54 C \\\\nATOM 2954 CG2 ILE A 372 -2.745 1.881 -11.307 1.00 98.54 C \\\\nATOM 2955 CD1 ILE A 372 -5.428 0.435 -10.644 1.00 98.54 C \\\\nATOM 2956 N ARG A 373 -0.136 1.158 -13.267 1.00 98.65 N \\\\nATOM 2957 CA ARG A 373 1.268 1.590 -13.178 1.00 98.65 C \\\\nATOM 2958 C ARG A 373 1.374 2.972 -12.567 1.00 98.65 C \\\\nATOM 2959 CB ARG A 373 1.950 1.501 -14.547 1.00 98.65 C \\\\nATOM 2960 O ARG A 373 0.597 3.860 -12.919 1.00 98.65 O \\\\nATOM 2961 CG ARG A 373 1.956 0.049 -15.037 1.00 98.65 C \\\\nATOM 2962 CD ARG A 373 2.780 -0.093 -16.310 1.00 98.65 C \\\\nATOM 2963 NE ARG A 373 2.808 -1.498 -16.728 1.00 98.65 N \\\\nATOM 2964 NH1 ARG A 373 1.773 -1.380 -18.785 1.00 98.65 N \\\\nATOM 2965 NH2 ARG A 373 2.486 -3.339 -17.937 1.00 98.65 N \\\\nATOM 2966 CZ ARG A 373 2.352 -2.053 -17.828 1.00 98.65 C \\\\nATOM 2967 N MET A 374 2.340 3.170 -11.670 1.00 98.70 N \\\\nATOM 2968 CA MET A 374 2.595 4.475 -11.055 1.00 98.70 C \\\\nATOM 2969 C MET A 374 4.073 4.844 -11.050 1.00 98.70 C \\\\nATOM 2970 CB MET A 374 2.054 4.573 -9.625 1.00 98.70 C \\\\nATOM 2971 O MET A 374 4.883 4.113 -10.489 1.00 98.70 O \\\\nATOM 2972 CG MET A 374 0.607 4.118 -9.491 1.00 98.70 C \\\\nATOM 2973 SD MET A 374 -0.088 4.536 -7.879 1.00 98.70 S \\\\nATOM 2974 CE MET A 374 -1.719 3.823 -8.145 1.00 98.70 C \\\\nATOM 2975 N SER A 375 4.416 6.010 -11.595 1.00 98.78 N \\\\nATOM 2976 CA SER A 375 5.757 6.597 -11.498 1.00 98.78 C \\\\nATOM 2977 C SER A 375 5.819 7.646 -10.391 1.00 98.78 C \\\\nATOM 2978 CB SER A 375 6.193 7.202 -12.831 1.00 98.78 C \\\\nATOM 2979 O SER A 375 4.895 8.447 -10.214 1.00 98.78 O \\\\nATOM 2980 OG SER A 375 7.441 7.846 -12.697 1.00 98.78 O \\\\nATOM 2981 N PHE A 376 6.942 7.680 -9.677 1.00 98.81 N \\\\nATOM 2982 CA PHE A 376 7.247 8.703 -8.685 1.00 98.81 C \\\\nATOM 2983 C PHE A 376 8.044 9.849 -9.319 1.00 98.81 C \\\\nATOM 2984 CB PHE A 376 8.019 8.080 -7.515 1.00 98.81 C \\\\nATOM 2985 O PHE A 376 9.028 9.620 -10.023 1.00 98.81 O \\\\nATOM 2986 CG PHE A 376 7.275 6.993 -6.762 1.00 98.81 C \\\\nATOM 2987 CD1 PHE A 376 6.403 7.336 -5.711 1.00 98.81 C \\\\nATOM 2988 CD2 PHE A 376 7.459 5.639 -7.102 1.00 98.81 C \\\\nATOM 2989 CE1 PHE A 376 5.723 6.330 -5.001 1.00 98.81 C \\\\nATOM 2990 CE2 PHE A 376 6.777 4.635 -6.393 1.00 98.81 C \\\\nATOM 2991 CZ PHE A 376 5.910 4.979 -5.342 1.00 98.81 C \\\\nATOM 2992 N VAL A 377 7.682 11.099 -9.004 1.00 98.56 N \\\\nATOM 2993 CA VAL A 377 8.406 12.346 -9.346 1.00 98.56 C \\\\nATOM 2994 C VAL A 377 8.447 12.701 -10.843 1.00 98.56 C \\\\nATOM 2995 CB VAL A 377 9.846 12.335 -8.774 1.00 98.56 C \\\\nATOM 2996 O VAL A 377 8.438 13.885 -11.182 1.00 98.56 O \\\\nATOM 2997 CG1 VAL A 377 10.498 13.724 -8.771 1.00 98.56 C \\\\nATOM 2998 CG2 VAL A 377 9.970 11.778 -7.346 1.00 98.56 C \\\\nATOM 2999 N LYS A 378 8.509 11.725 -11.758 1.00 98.24 N \\\\nATOM 3000 CA LYS A 378 8.670 11.928 -13.209 1.00 98.24 C \\\\nATOM 3001 C LYS A 378 7.483 11.353 -13.989 1.00 98.24 C \\\\nATOM 3002 CB LYS A 378 9.996 11.299 -13.693 1.00 98.24 C \\\\nATOM 3003 O LYS A 378 7.233 10.155 -13.919 1.00 98.24 O \\\\nATOM 3004 CG LYS A 378 11.266 11.754 -12.948 1.00 98.24 C \\\\nATOM 3005 CD LYS A 378 11.501 13.272 -12.973 1.00 98.24 C \\\\nATOM 3006 CE LYS A 378 12.773 13.608 -12.185 1.00 98.24 C \\\\nATOM 3007 NZ LYS A 378 12.933 15.073 -12.002 1.00 98.24 N \\\\nATOM 3008 N GLY A 379 6.803 12.192 -14.767 1.00 97.29 N \\\\nATOM 3009 CA GLY A 379 5.748 11.760 -15.689 1.00 97.29 C \\\\nATOM 3010 C GLY A 379 6.277 11.053 -16.939 1.00 97.29 C \\\\nATOM 3011 O GLY A 379 7.464 11.159 -17.273 1.00 97.29 O \\\\nATOM 3012 N TRP A 380 5.368 10.348 -17.612 1.00 98.27 N \\\\nATOM 3013 CA TRP A 380 5.543 9.736 -18.930 1.00 98.27 C \\\\nATOM 3014 C TRP A 380 4.223 9.790 -19.721 1.00 98.27 C \\\\nATOM 3015 CB TRP A 380 6.049 8.290 -18.793 1.00 98.27 C \\\\nATOM 3016 O TRP A 380 3.188 10.128 -19.148 1.00 98.27 O \\\\nATOM 3017 CG TRP A 380 5.001 7.249 -18.540 1.00 98.27 C \\\\nATOM 3018 CD1 TRP A 380 4.437 6.468 -19.491 1.00 98.27 C \\\\nATOM 3019 CD2 TRP A 380 4.327 6.901 -17.293 1.00 98.27 C \\\\nATOM 3020 CE2 TRP A 380 3.395 5.855 -17.564 1.00 98.27 C \\\\nATOM 3021 CE3 TRP A 380 4.395 7.369 -15.962 1.00 98.27 C \\\\nATOM 3022 NE1 TRP A 380 3.495 5.638 -18.919 1.00 98.27 N \\\\nATOM 3023 CH2 TRP A 380 2.678 5.771 -15.259 1.00 98.27 C \\\\nATOM 3024 CZ2 TRP A 380 2.605 5.271 -16.567 1.00 98.27 C \\\\nATOM 3025 CZ3 TRP A 380 3.563 6.822 -14.967 1.00 98.27 C \\\\nATOM 3026 N GLY A 381 4.259 9.453 -21.010 1.00 95.83 N \\\\nATOM 3027 CA GLY A 381 3.134 9.560 -21.944 1.00 95.83 C \\\\nATOM 3028 C GLY A 381 3.169 10.863 -22.749 1.00 95.83 C \\\\nATOM 3029 O GLY A 381 4.135 11.616 -22.647 1.00 95.83 O \\\\nATOM 3030 N ALA A 382 2.109 11.126 -23.522 1.00 92.96 N \\\\nATOM 3031 CA ALA A 382 2.044 12.198 -24.528 1.00 92.96 C \\\\nATOM 3032 C ALA A 382 2.542 13.575 -24.035 1.00 92.96 C \\\\nATOM 3033 CB ALA A 382 0.592 12.282 -25.020 1.00 92.96 C \\\\nATOM 3034 O ALA A 382 3.350 14.214 -24.702 1.00 92.96 O \\\\nATOM 3035 N GLU A 383 2.152 13.976 -22.821 1.00 91.46 N \\\\nATOM 3036 CA GLU A 383 2.499 15.270 -22.206 1.00 91.46 C \\\\nATOM 3037 C GLU A 383 3.948 15.372 -21.678 1.00 91.46 C \\\\nATOM 3038 CB GLU A 383 1.507 15.559 -21.063 1.00 91.46 C \\\\nATOM 3039 O GLU A 383 4.318 16.347 -21.019 1.00 91.46 O \\\\nATOM 3040 CG GLU A 383 0.031 15.522 -21.482 1.00 91.46 C \\\\nATOM 3041 CD GLU A 383 -0.228 16.402 -22.707 1.00 91.46 C \\\\nATOM 3042 OE1 GLU A 383 -0.810 15.863 -23.671 1.00 91.46 O \\\\nATOM 3043 OE2 GLU A 383 0.203 17.575 -22.659 1.00 91.46 O \\\\nATOM 3044 N TYR A 384 4.787 14.351 -21.888 1.00 95.61 N \\\\nATOM 3045 CA TYR A 384 6.121 14.262 -21.297 1.00 95.61 C \\\\nATOM 3046 C TYR A 384 7.166 13.757 -22.295 1.00 95.61 C \\\\nATOM 3047 CB TYR A 384 6.084 13.357 -20.051 1.00 95.61 C \\\\nATOM 3048 O TYR A 384 6.925 12.880 -23.113 1.00 95.61 O \\\\nATOM 3049 CG TYR A 384 5.120 13.811 -18.968 1.00 95.61 C \\\\nATOM 3050 CD1 TYR A 384 5.477 14.837 -18.069 1.00 95.61 C \\\\nATOM 3051 CD2 TYR A 384 3.824 13.267 -18.924 1.00 95.61 C \\\\nATOM 3052 CE1 TYR A 384 4.523 15.344 -17.162 1.00 95.61 C \\\\nATOM 3053 CE2 TYR A 384 2.872 13.758 -18.015 1.00 95.61 C \\\\nATOM 3054 OH TYR A 384 2.248 15.383 -16.376 1.00 95.61 O \\\\nATOM 3055 CZ TYR A 384 3.208 14.827 -17.161 1.00 95.61 C \\\\nATOM 3056 N ARG A 385 8.418 14.209 -22.132 1.00 95.60 N \\\\nATOM 3057 CA ARG A 385 9.572 13.721 -22.919 1.00 95.60 C \\\\nATOM 3058 C ARG A 385 9.787 12.195 -22.835 1.00 95.60 C \\\\nATOM 3059 CB ARG A 385 10.822 14.516 -22.492 1.00 95.60 C \\\\nATOM 3060 O ARG A 385 10.451 11.618 -23.689 1.00 95.60 O \\\\nATOM 3061 CG ARG A 385 12.085 14.098 -23.262 1.00 95.60 C \\\\nATOM 3062 CD ARG A 385 13.284 15.003 -22.977 1.00 95.60 C \\\\nATOM 3063 NE ARG A 385 14.513 14.388 -23.516 1.00 95.60 N \\\\nATOM 3064 NH1 ARG A 385 15.973 15.009 -21.858 1.00 95.60 N \\\\nATOM 3065 NH2 ARG A 385 16.623 13.531 -23.347 1.00 95.60 N \\\\nATOM 3066 CZ ARG A 385 15.687 14.316 -22.919 1.00 95.60 C \\\\nATOM 3067 N ARG A 386 9.276 11.538 -21.790 1.00 96.56 N \\\\nATOM 3068 CA ARG A 386 9.328 10.080 -21.615 1.00 96.56 C \\\\nATOM 3069 C ARG A 386 8.064 9.473 -22.206 1.00 96.56 C \\\\nATOM 3070 CB ARG A 386 9.416 9.737 -20.120 1.00 96.56 C \\\\nATOM 3071 O ARG A 386 7.011 9.641 -21.612 1.00 96.56 O \\\\nATOM 3072 CG ARG A 386 10.779 10.093 -19.533 1.00 96.56 C \\\\nATOM 3073 CD ARG A 386 10.772 9.857 -18.020 1.00 96.56 C \\\\nATOM 3074 NE ARG A 386 12.126 10.031 -17.471 1.00 96.56 N \\\\nATOM 3075 NH1 ARG A 386 12.152 12.322 -17.440 1.00 96.56 N \\\\nATOM 3076 NH2 ARG A 386 14.040 11.183 -17.055 1.00 96.56 N \\\\nATOM 3077 CZ ARG A 386 12.764 11.175 -17.316 1.00 96.56 C \\\\nATOM 3078 N GLN A 387 8.162 8.731 -23.303 1.00 96.27 N \\\\nATOM 3079 CA GLN A 387 6.978 8.072 -23.868 1.00 96.27 C \\\\nATOM 3080 C GLN A 387 6.599 6.798 -23.101 1.00 96.27 C \\\\nATOM 3081 CB GLN A 387 7.175 7.829 -25.375 1.00 96.27 C \\\\nATOM 3082 O GLN A 387 5.418 6.542 -22.877 1.00 96.27 O \\\\nATOM 3083 CG GLN A 387 7.368 9.140 -26.168 1.00 96.27 C \\\\nATOM 3084 CD GLN A 387 6.268 10.168 -25.894 1.00 96.27 C \\\\nATOM 3085 NE2 GLN A 387 6.591 11.439 -25.828 1.00 96.27 N \\\\nATOM 3086 OE1 GLN A 387 5.116 9.840 -25.663 1.00 96.27 O \\\\nATOM 3087 N THR A 388 7.585 6.039 -22.609 1.00 96.77 N \\\\nATOM 3088 CA THR A 388 7.359 4.769 -21.901 1.00 96.77 C \\\\nATOM 3089 C THR A 388 7.482 4.891 -20.379 1.00 96.77 C \\\\nATOM 3090 CB THR A 388 8.262 3.641 -22.424 1.00 96.77 C \\\\nATOM 3091 O THR A 388 8.281 5.683 -19.868 1.00 96.77 O \\\\nATOM 3092 CG2 THR A 388 8.328 3.568 -23.951 1.00 96.77 C \\\\nATOM 3093 OG1 THR A 388 9.576 3.812 -21.939 1.00 96.77 O \\\\nATOM 3094 N VAL A 389 6.756 4.048 -19.633 1.00 97.45 N \\\\nATOM 3095 CA VAL A 389 6.912 3.957 -18.167 1.00 97.45 C \\\\nATOM 3096 C VAL A 389 8.310 3.454 -17.785 1.00 97.45 C \\\\nATOM 3097 CB VAL A 389 5.801 3.086 -17.550 1.00 97.45 C \\\\nATOM 3098 O VAL A 389 8.912 3.944 -16.831 1.00 97.45 O \\\\nATOM 3099 CG1 VAL A 389 5.955 1.595 -17.873 1.00 97.45 C \\\\nATOM 3100 CG2 VAL A 389 5.724 3.294 -16.035 1.00 97.45 C \\\\nATOM 3101 N THR A 390 8.887 2.575 -18.610 1.00 97.99 N \\\\nATOM 3102 CA THR A 390 10.258 2.053 -18.489 1.00 97.99 C \\\\nATOM 3103 C THR A 390 11.346 3.119 -18.676 1.00 97.99 C \\\\nATOM 3104 CB THR A 390 10.484 0.908 -19.489 1.00 97.99 C \\\\nATOM 3105 O THR A 390 12.499 2.887 -18.328 1.00 97.99 O \\\\nATOM 3106 CG2 THR A 390 9.628 -0.312 -19.156 1.00 97.99 C \\\\nATOM 3107 OG1 THR A 390 10.131 1.299 -20.801 1.00 97.99 O \\\\nATOM 3108 N SER A 391 10.993 4.315 -19.163 1.00 97.57 N \\\\nATOM 3109 CA SER A 391 11.880 5.488 -19.190 1.00 97.57 C \\\\nATOM 3110 C SER A 391 11.865 6.287 -17.876 1.00 97.57 C \\\\nATOM 3111 CB SER A 391 11.491 6.413 -20.347 1.00 97.57 C \\\\nATOM 3112 O SER A 391 12.628 7.250 -17.716 1.00 97.57 O \\\\nATOM 3113 OG SER A 391 11.570 5.771 -21.600 1.00 97.57 O \\\\nATOM 3114 N THR A 392 10.972 5.959 -16.936 1.00 98.21 N \\\\nATOM 3115 CA THR A 392 10.876 6.643 -15.639 1.00 98.21 C \\\\nATOM 3116 C THR A 392 11.872 6.052 -14.631 1.00 98.21 C \\\\nATOM 3117 CB THR A 392 9.458 6.672 -15.051 1.00 98.21 C \\\\nATOM 3118 O THR A 392 12.089 4.840 -14.616 1.00 98.21 O \\\\nATOM 3119 CG2 THR A 392 8.388 7.194 -16.015 1.00 98.21 C \\\\nATOM 3120 OG1 THR A 392 9.084 5.412 -14.573 1.00 98.21 O \\\\nATOM 3121 N PRO A 393 12.518 6.866 -13.771 1.00 98.48 N \\\\nATOM 3122 CA PRO A 393 13.592 6.349 -12.921 1.00 98.48 C \\\\nATOM 3123 C PRO A 393 13.100 5.443 -11.783 1.00 98.48 C \\\\nATOM 3124 CB PRO A 393 14.326 7.582 -12.381 1.00 98.48 C \\\\nATOM 3125 O PRO A 393 13.865 4.617 -11.299 1.00 98.48 O \\\\nATOM 3126 CG PRO A 393 13.897 8.717 -13.306 1.00 98.48 C \\\\nATOM 3127 CD PRO A 393 12.477 8.318 -13.683 1.00 98.48 C \\\\nATOM 3128 N CYS A 394 11.856 5.613 -11.327 1.00 98.74 N \\\\nATOM 3129 CA CYS A 394 11.266 4.879 -10.207 1.00 98.74 C \\\\nATOM 3130 C CYS A 394 9.761 4.723 -10.431 1.00 98.74 C \\\\nATOM 3131 CB CYS A 394 11.484 5.670 -8.905 1.00 98.74 C \\\\nATOM 3132 O CYS A 394 9.036 5.719 -10.370 1.00 98.74 O \\\\nATOM 3133 SG CYS A 394 13.241 5.820 -8.497 1.00 98.74 S \\\\nATOM 3134 N TRP A 395 9.288 3.495 -10.619 1.00 98.82 N \\\\nATOM 3135 CA TRP A 395 7.864 3.208 -10.776 1.00 98.82 C \\\\nATOM 3136 C TRP A 395 7.477 1.861 -10.162 1.00 98.82 C \\\\nATOM 3137 CB TRP A 395 7.465 3.314 -12.257 1.00 98.82 C \\\\nATOM 3138 O TRP A 395 8.329 1.046 -9.813 1.00 98.82 O \\\\nATOM 3139 CG TRP A 395 8.092 2.330 -13.189 1.00 98.82 C \\\\nATOM 3140 CD1 TRP A 395 9.343 2.411 -13.690 1.00 98.82 C \\\\nATOM 3141 CD2 TRP A 395 7.504 1.123 -13.769 1.00 98.82 C \\\\nATOM 3142 CE2 TRP A 395 8.473 0.520 -14.624 1.00 98.82 C \\\\nATOM 3143 CE3 TRP A 395 6.250 0.480 -13.671 1.00 98.82 C \\\\nATOM 3144 NE1 TRP A 395 9.567 1.348 -14.535 1.00 98.82 N \\\\nATOM 3145 CH2 TRP A 395 6.985 -1.301 -15.179 1.00 98.82 C \\\\nATOM 3146 CZ2 TRP A 395 8.237 -0.677 -15.311 1.00 98.82 C \\\\nATOM 3147 CZ3 TRP A 395 5.993 -0.713 -14.374 1.00 98.82 C \\\\nATOM 3148 N ILE A 396 6.178 1.660 -9.978 1.00 98.81 N \\\\nATOM 3149 CA ILE A 396 5.573 0.439 -9.447 1.00 98.81 C \\\\nATOM 3150 C ILE A 396 4.464 -0.057 -10.370 1.00 98.81 C \\\\nATOM 3151 CB ILE A 396 5.055 0.618 -7.998 1.00 98.81 C \\\\nATOM 3152 O ILE A 396 3.745 0.736 -10.983 1.00 98.81 O \\\\nATOM 3153 CG1 ILE A 396 4.207 1.900 -7.835 1.00 98.81 C \\\\nATOM 3154 CG2 ILE A 396 6.250 0.602 -7.030 1.00 98.81 C \\\\nATOM 3155 CD1 ILE A 396 3.470 2.058 -6.498 1.00 98.81 C \\\\nATOM 3156 N GLU A 397 4.315 -1.374 -10.421 1.00 98.72 N \\\\nATOM 3157 CA GLU A 397 3.209 -2.078 -11.062 1.00 98.72 C \\\\nATOM 3158 C GLU A 397 2.344 -2.726 -9.976 1.00 98.72 C \\\\nATOM 3159 CB GLU A 397 3.781 -3.100 -12.056 1.00 98.72 C \\\\nATOM 3160 O GLU A 397 2.847 -3.509 -9.169 1.00 98.72 O \\\\nATOM 3161 CG GLU A 397 2.709 -3.684 -12.983 1.00 98.72 C \\\\nATOM 3162 CD GLU A 397 3.354 -4.370 -14.196 1.00 98.72 C \\\\nATOM 3163 OE1 GLU A 397 4.027 -5.404 -14.009 1.00 98.72 O \\\\nATOM 3164 OE2 GLU A 397 3.229 -3.803 -15.313 1.00 98.72 O \\\\nATOM 3165 N LEU A 398 1.064 -2.356 -9.931 1.00 98.36 N \\\\nATOM 3166 CA LEU A 398 0.030 -2.936 -9.076 1.00 98.36 C \\\\nATOM 3167 C LEU A 398 -0.766 -3.952 -9.890 1.00 98.36 C \\\\nATOM 3168 CB LEU A 398 -0.960 -1.852 -8.600 1.00 98.36 C \\\\nATOM 3169 O LEU A 398 -1.309 -3.596 -10.934 1.00 98.36 O \\\\nATOM 3170 CG LEU A 398 -0.604 -1.058 -7.342 1.00 98.36 C \\\\nATOM 3171 CD1 LEU A 398 0.694 -0.268 -7.468 1.00 98.36 C \\\\nATOM 3172 CD2 LEU A 398 -1.738 -0.065 -7.071 1.00 98.36 C \\\\nATOM 3173 N HIS A 399 -0.933 -5.157 -9.358 1.00 98.32 N \\\\nATOM 3174 CA HIS A 399 -1.912 -6.134 -9.832 1.00 98.32 C \\\\nATOM 3175 C HIS A 399 -3.045 -6.261 -8.817 1.00 98.32 C \\\\nATOM 3176 CB HIS A 399 -1.212 -7.476 -10.077 1.00 98.32 C \\\\nATOM 3177 O HIS A 399 -2.795 -6.535 -7.642 1.00 98.32 O \\\\nATOM 3178 CG HIS A 399 -0.309 -7.495 -11.284 1.00 98.32 C \\\\nATOM 3179 CD2 HIS A 399 -0.246 -6.557 -12.278 1.00 98.32 C \\\\nATOM 3180 ND1 HIS A 399 0.574 -8.494 -11.622 1.00 98.32 N \\\\nATOM 3181 CE1 HIS A 399 1.150 -8.160 -12.792 1.00 98.32 C \\\\nATOM 3182 NE2 HIS A 399 0.669 -6.989 -13.236 1.00 98.32 N \\\\nATOM 3183 N LEU A 400 -4.286 -6.050 -9.260 1.00 98.07 N \\\\nATOM 3184 CA LEU A 400 -5.481 -6.181 -8.426 1.00 98.07 C \\\\nATOM 3185 C LEU A 400 -5.967 -7.633 -8.445 1.00 98.07 C \\\\nATOM 3186 CB LEU A 400 -6.556 -5.184 -8.888 1.00 98.07 C \\\\nATOM 3187 O LEU A 400 -6.554 -8.105 -9.419 1.00 98.07 O \\\\nATOM 3188 CG LEU A 400 -6.121 -3.708 -8.840 1.00 98.07 C \\\\nATOM 3189 CD1 LEU A 400 -7.303 -2.837 -9.244 1.00 98.07 C \\\\nATOM 3190 CD2 LEU A 400 -5.657 -3.258 -7.451 1.00 98.07 C \\\\nATOM 3191 N ASN A 401 -5.706 -8.350 -7.354 1.00 97.27 N \\\\nATOM 3192 CA ASN A 401 -5.823 -9.807 -7.309 1.00 97.27 C \\\\nATOM 3193 C ASN A 401 -7.278 -10.291 -7.399 1.00 97.27 C \\\\nATOM 3194 CB ASN A 401 -5.159 -10.310 -6.019 1.00 97.27 C \\\\nATOM 3195 O ASN A 401 -7.529 -11.344 -7.975 1.00 97.27 O \\\\nATOM 3196 CG ASN A 401 -3.660 -10.068 -5.942 1.00 97.27 C \\\\nATOM 3197 ND2 ASN A 401 -3.127 -10.033 -4.747 1.00 97.27 N \\\\nATOM 3198 OD1 ASN A 401 -2.948 -9.899 -6.917 1.00 97.27 O \\\\nATOM 3199 N GLY A 402 -8.237 -9.532 -6.858 1.00 95.66 N \\\\nATOM 3200 CA GLY A 402 -9.663 -9.875 -6.913 1.00 95.66 C \\\\nATOM 3201 C GLY A 402 -10.217 -9.810 -8.341 1.00 95.66 C \\\\nATOM 3202 O GLY A 402 -10.705 -10.824 -8.843 1.00 95.66 O \\\\nATOM 3203 N PRO A 403 -10.083 -8.665 -9.040 1.00 96.62 N \\\\nATOM 3204 CA PRO A 403 -10.371 -8.549 -10.469 1.00 96.62 C \\\\nATOM 3205 C PRO A 403 -9.676 -9.615 -11.333 1.00 96.62 C \\\\nATOM 3206 CB PRO A 403 -9.945 -7.123 -10.839 1.00 96.62 C \\\\nATOM 3207 O PRO A 403 -10.339 -10.236 -12.160 1.00 96.62 O \\\\nATOM 3208 CG PRO A 403 -10.232 -6.348 -9.555 1.00 96.62 C \\\\nATOM 3209 CD PRO A 403 -9.818 -7.347 -8.476 1.00 96.62 C \\\\nATOM 3210 N LEU A 404 -8.385 -9.904 -11.099 1.00 96.80 N \\\\nATOM 3211 CA LEU A 404 -7.666 -10.983 -11.798 1.00 96.80 C \\\\nATOM 3212 C LEU A 404 -8.263 -12.371 -11.528 1.00 96.80 C \\\\nATOM 3213 CB LEU A 404 -6.174 -10.983 -11.410 1.00 96.80 C \\\\nATOM 3214 O LEU A 404 -8.483 -13.127 -12.468 1.00 96.80 O \\\\nATOM 3215 CG LEU A 404 -5.348 -9.857 -12.047 1.00 96.80 C \\\\nATOM 3216 CD1 LEU A 404 -3.952 -9.816 -11.431 1.00 96.80 C \\\\nATOM 3217 CD2 LEU A 404 -5.193 -10.022 -13.561 1.00 96.80 C \\\\nATOM 3218 N GLN A 405 -8.560 -12.711 -10.271 1.00 94.96 N \\\\nATOM 3219 CA GLN A 405 -9.154 -14.005 -9.921 1.00 94.96 C \\\\nATOM 3220 C GLN A 405 -10.559 -14.168 -10.515 1.00 94.96 C \\\\nATOM 3221 CB GLN A 405 -9.194 -14.155 -8.390 1.00 94.96 C \\\\nATOM 3222 O GLN A 405 -10.961 -15.273 -10.878 1.00 94.96 O \\\\nATOM 3223 CG GLN A 405 -9.640 -15.569 -7.985 1.00 94.96 C \\\\nATOM 3224 CD GLN A 405 -9.740 -15.779 -6.480 1.00 94.96 C \\\\nATOM 3225 NE2 GLN A 405 -9.435 -16.962 -5.997 1.00 94.96 N \\\\nATOM 3226 OE1 GLN A 405 -10.159 -14.935 -5.711 1.00 94.96 O \\\\nATOM 3227 N TRP A 406 -11.330 -13.084 -10.611 1.00 94.76 N \\\\nATOM 3228 CA TRP A 406 -12.641 -13.131 -11.250 1.00 94.76 C \\\\nATOM 3229 C TRP A 406 -12.522 -13.339 -12.760 1.00 94.76 C \\\\nATOM 3230 CB TRP A 406 -13.421 -11.861 -10.921 1.00 94.76 C \\\\nATOM 3231 O TRP A 406 -13.245 -14.162 -13.318 1.00 94.76 O \\\\nATOM 3232 CG TRP A 406 -14.901 -11.926 -11.139 1.00 94.76 C \\\\nATOM 3233 CD1 TRP A 406 -15.639 -13.020 -11.452 1.00 94.76 C \\\\nATOM 3234 CD2 TRP A 406 -15.853 -10.833 -11.027 1.00 94.76 C \\\\nATOM 3235 CE2 TRP A 406 -17.167 -11.362 -11.172 1.00 94.76 C \\\\nATOM 3236 CE3 TRP A 406 -15.734 -9.448 -10.788 1.00 94.76 C \\\\nATOM 3237 NE1 TRP A 406 -16.980 -12.692 -11.466 1.00 94.76 N \\\\nATOM 3238 CH2 TRP A 406 -18.161 -9.205 -10.753 1.00 94.76 C \\\\nATOM 3239 CZ2 TRP A 406 -18.308 -10.573 -11.020 1.00 94.76 C \\\\nATOM 3240 CZ3 TRP A 406 -16.875 -8.643 -10.643 1.00 94.76 C \\\\nATOM 3241 N LEU A 407 -11.569 -12.651 -13.393 1.00 95.07 N \\\\nATOM 3242 CA LEU A 407 -11.270 -12.788 -14.812 1.00 95.07 C \\\\nATOM 3243 C LEU A 407 -10.824 -14.213 -15.175 1.00 95.07 C \\\\nATOM 3244 CB LEU A 407 -10.192 -11.749 -15.164 1.00 95.07 C \\\\nATOM 3245 O LEU A 407 -11.353 -14.798 -16.115 1.00 95.07 O \\\\nATOM 3246 CG LEU A 407 -9.929 -11.642 -16.669 1.00 95.07 C \\\\nATOM 3247 CD1 LEU A 407 -11.149 -11.068 -17.375 1.00 95.07 C \\\\nATOM 3248 CD2 LEU A 407 -8.748 -10.715 -16.923 1.00 95.07 C \\\\nATOM 3249 N ASP A 408 -9.917 -14.797 -14.390 1.00 93.11 N \\\\nATOM 3250 CA ASP A 408 -9.437 -16.178 -14.539 1.00 93.11 C \\\\nATOM 3251 C ASP A 408 -10.587 -17.204 -14.477 1.00 93.11 C \\\\nATOM 3252 CB ASP A 408 -8.399 -16.419 -13.435 1.00 93.11 C \\\\nATOM 3253 O ASP A 408 -10.728 -18.059 -15.355 1.00 93.11 O \\\\nATOM 3254 CG ASP A 408 -7.860 -17.847 -13.445 1.00 93.11 C \\\\nATOM 3255 OD1 ASP A 408 -7.091 -18.163 -14.378 1.00 93.11 O \\\\nATOM 3256 OD2 ASP A 408 -8.220 -18.594 -12.507 1.00 93.11 O \\\\nATOM 3257 N LYS A 409 -11.502 -17.057 -13.508 1.00 92.52 N \\\\nATOM 3258 CA LYS A 409 -12.709 -17.897 -13.397 1.00 92.52 C \\\\nATOM 3259 C LYS A 409 -13.689 -17.758 -14.570 1.00 92.52 C \\\\nATOM 3260 CB LYS A 409 -13.466 -17.549 -12.121 1.00 92.52 C \\\\nATOM 3261 O LYS A 409 -14.478 -18.674 -14.795 1.00 92.52 O \\\\nATOM 3262 CG LYS A 409 -12.815 -18.012 -10.816 1.00 92.52 C \\\\nATOM 3263 CD LYS A 409 -13.636 -17.364 -9.697 1.00 92.52 C \\\\nATOM 3264 CE LYS A 409 -13.255 -17.844 -8.303 1.00 92.52 C \\\\nATOM 3265 NZ LYS A 409 -14.099 -17.132 -7.314 1.00 92.52 N \\\\nATOM 3266 N VAL A 410 -13.695 -16.619 -15.268 1.00 92.90 N \\\\nATOM 3267 CA VAL A 410 -14.493 -16.418 -16.489 1.00 92.90 C \\\\nATOM 3268 C VAL A 410 -13.777 -17.046 -17.685 1.00 92.90 C \\\\nATOM 3269 CB VAL A 410 -14.818 -14.925 -16.709 1.00 92.90 C \\\\nATOM 3270 O VAL A 410 -14.371 -17.866 -18.380 1.00 92.90 O \\\\nATOM 3271 CG1 VAL A 410 -15.438 -14.649 -18.082 1.00 92.90 C \\\\nATOM 3272 CG2 VAL A 410 -15.821 -14.432 -15.656 1.00 92.90 C \\\\nATOM 3273 N LEU A 411 -12.490 -16.743 -17.889 1.00 91.89 N \\\\nATOM 3274 CA LEU A 411 -11.679 -17.284 -18.988 1.00 91.89 C \\\\nATOM 3275 C LEU A 411 -11.652 -18.818 -18.994 1.00 91.89 C \\\\nATOM 3276 CB LEU A 411 -10.248 -16.723 -18.887 1.00 91.89 C \\\\nATOM 3277 O LEU A 411 -11.850 -19.428 -20.042 1.00 91.89 O \\\\nATOM 3278 CG LEU A 411 -10.117 -15.253 -19.320 1.00 91.89 C \\\\nATOM 3279 CD1 LEU A 411 -8.733 -14.724 -18.945 1.00 91.89 C \\\\nATOM 3280 CD2 LEU A 411 -10.290 -15.094 -20.834 1.00 91.89 C \\\\nATOM 3281 N THR A 412 -11.507 -19.444 -17.823 1.00 89.09 N \\\\nATOM 3282 CA THR A 412 -11.554 -20.911 -17.663 1.00 89.09 C \\\\nATOM 3283 C THR A 412 -12.888 -21.550 -18.070 1.00 89.09 C \\\\nATOM 3284 CB THR A 412 -11.218 -21.336 -16.222 1.00 89.09 C \\\\nATOM 3285 O THR A 412 -12.927 -22.757 -18.300 1.00 89.09 O \\\\nATOM 3286 CG2 THR A 412 -9.732 -21.190 -15.906 1.00 89.09 C \\\\nATOM 3287 OG1 THR A 412 -11.912 -20.558 -15.277 1.00 89.09 O \\\\nATOM 3288 N GLN A 413 -13.972 -20.775 -18.201 1.00 86.81 N \\\\nATOM 3289 CA GLN A 413 -15.280 -21.252 -18.672 1.00 86.81 C \\\\nATOM 3290 C GLN A 413 -15.551 -20.940 -20.153 1.00 86.81 C \\\\nATOM 3291 CB GLN A 413 -16.392 -20.705 -17.761 1.00 86.81 C \\\\nATOM 3292 O GLN A 413 -16.411 -21.583 -20.748 1.00 86.81 O \\\\nATOM 3293 CG GLN A 413 -16.258 -21.285 -16.347 1.00 86.81 C \\\\nATOM 3294 CD GLN A 413 -17.349 -20.835 -15.387 1.00 86.81 C \\\\nATOM 3295 NE2 GLN A 413 -17.067 -20.833 -14.103 1.00 86.81 N \\\\nATOM 3296 OE1 GLN A 413 -18.474 -20.520 -15.728 1.00 86.81 O \\\\nATOM 3297 N MET A 414 -14.802 -20.018 -20.773 1.00 85.54 N \\\\nATOM 3298 CA MET A 414 -14.980 -19.637 -22.185 1.00 85.54 C \\\\nATOM 3299 C MET A 414 -14.133 -20.455 -23.177 1.00 85.54 C \\\\nATOM 3300 CB MET A 414 -14.761 -18.132 -22.380 1.00 85.54 C \\\\nATOM 3301 O MET A 414 -14.115 -20.160 -24.369 1.00 85.54 O \\\\nATOM 3302 CG MET A 414 -15.737 -17.300 -21.541 1.00 85.54 C \\\\nATOM 3303 SD MET A 414 -15.963 -15.552 -21.980 1.00 85.54 S \\\\nATOM 3304 CE MET A 414 -14.405 -15.179 -22.806 1.00 85.54 C \\\\nATOM 3305 N GLY A 415 -13.432 -21.496 -22.723 1.00 82.14 N \\\\nATOM 3306 CA GLY A 415 -12.658 -22.373 -23.604 1.00 82.14 C \\\\nATOM 3307 C GLY A 415 -11.343 -21.744 -24.076 1.00 82.14 C \\\\nATOM 3308 O GLY A 415 -10.474 -21.450 -23.260 1.00 82.14 O \\\\nATOM 3309 N SER A 416 -11.159 -21.607 -25.392 1.00 81.44 N \\\\nATOM 3310 CA SER A 416 -9.897 -21.178 -26.015 1.00 81.44 C \\\\nATOM 3311 C SER A 416 -10.125 -20.213 -27.186 1.00 81.44 C \\\\nATOM 3312 CB SER A 416 -9.114 -22.408 -26.502 1.00 81.44 C \\\\nATOM 3313 O SER A 416 -11.213 -20.226 -27.766 1.00 81.44 O \\\\nATOM 3314 OG SER A 416 -9.784 -23.090 -27.551 1.00 81.44 O \\\\nATOM 3315 N PRO A 417 -9.103 -19.446 -27.618 1.00 82.09 N \\\\nATOM 3316 CA PRO A 417 -9.158 -18.678 -28.861 1.00 82.09 C \\\\nATOM 3317 C PRO A 417 -9.571 -19.530 -30.072 1.00 82.09 C \\\\nATOM 3318 CB PRO A 417 -7.753 -18.096 -29.059 1.00 82.09 C \\\\nATOM 3319 O PRO A 417 -9.239 -20.715 -30.158 1.00 82.09 O \\\\nATOM 3320 CG PRO A 417 -7.186 -18.034 -27.644 1.00 82.09 C \\\\nATOM 3321 CD PRO A 417 -7.814 -19.252 -26.967 1.00 82.09 C \\\\nATOM 3322 N SER A 418 -10.262 -18.910 -31.031 1.00 80.99 N \\\\nATOM 3323 CA SER A 418 -10.662 -19.545 -32.296 1.00 80.99 C \\\\nATOM 3324 C SER A 418 -9.466 -19.816 -33.218 1.00 80.99 C \\\\nATOM 3325 CB SER A 418 -11.680 -18.649 -33.011 1.00 80.99 C \\\\nATOM 3326 O SER A 418 -9.413 -20.846 -33.893 1.00 80.99 O \\\\nATOM 3327 OG SER A 418 -11.172 -17.331 -33.132 1.00 80.99 O \\\\nATOM 3328 N ILE A 419 -8.483 -18.912 -33.221 1.00 81.26 N \\\\nATOM 3329 CA ILE A 419 -7.231 -19.055 -33.965 1.00 81.26 C \\\\nATOM 3330 C ILE A 419 -6.295 -19.973 -33.174 1.00 81.26 C \\\\nATOM 3331 CB ILE A 419 -6.594 -17.676 -34.263 1.00 81.26 C \\\\nATOM 3332 O ILE A 419 -5.882 -19.659 -32.058 1.00 81.26 O \\\\nATOM 3333 CG1 ILE A 419 -7.578 -16.783 -35.058 1.00 81.26 C \\\\nATOM 3334 CG2 ILE A 419 -5.278 -17.863 -35.045 1.00 81.26 C \\\\nATOM 3335 CD1 ILE A 419 -7.081 -15.352 -35.301 1.00 81.26 C \\\\nATOM 3336 N ARG A 420 -5.929 -21.114 -33.767 1.00 83.97 N \\\\nATOM 3337 CA ARG A 420 -4.920 -22.014 -33.193 1.00 83.97 C \\\\nATOM 3338 C ARG A 420 -3.526 -21.423 -33.385 1.00 83.97 C \\\\nATOM 3339 CB ARG A 420 -5.003 -23.414 -33.814 1.00 83.97 C \\\\nATOM 3340 O ARG A 420 -3.164 -21.055 -34.499 1.00 83.97 O \\\\nATOM 3341 CG ARG A 420 -6.335 -24.106 -33.502 1.00 83.97 C \\\\nATOM 3342 CD ARG A 420 -6.312 -25.543 -34.028 1.00 83.97 C \\\\nATOM 3343 NE ARG A 420 -7.597 -26.219 -33.779 1.00 83.97 N \\\\nATOM 3344 NH1 ARG A 420 -6.954 -28.339 -34.384 1.00 83.97 N \\\\nATOM 3345 NH2 ARG A 420 -9.053 -27.965 -33.716 1.00 83.97 N \\\\nATOM 3346 CZ ARG A 420 -7.860 -27.500 -33.960 1.00 83.97 C \\\\nATOM 3347 N CYS A 421 -2.733 -21.398 -32.318 1.00 83.68 N \\\\nATOM 3348 CA CYS A 421 -1.320 -21.044 -32.406 1.00 83.68 C \\\\nATOM 3349 C CYS A 421 -0.531 -22.142 -33.143 1.00 83.68 C \\\\nATOM 3350 CB CYS A 421 -0.786 -20.779 -30.993 1.00 83.68 C \\\\nATOM 3351 O CYS A 421 -0.792 -23.334 -32.955 1.00 83.68 O \\\\nATOM 3352 SG CYS A 421 0.817 -19.947 -31.129 1.00 83.68 S \\\\nATOM 3353 N SER A 422 0.433 -21.746 -33.976 1.00 85.93 N \\\\nATOM 3354 CA SER A 422 1.379 -22.670 -34.607 1.00 85.93 C \\\\nATOM 3355 C SER A 422 2.461 -23.078 -33.607 1.00 85.93 C \\\\nATOM 3356 CB SER A 422 2.006 -22.014 -35.839 1.00 85.93 C \\\\nATOM 3357 O SER A 422 2.934 -22.264 -32.823 1.00 85.93 O \\\\nATOM 3358 OG SER A 422 3.003 -22.843 -36.411 1.00 85.93 O \\\\nATOM 3359 N SER A 423 2.904 -24.335 -33.658 1.00 89.58 N \\\\nATOM 3360 CA SER A 423 4.051 -24.816 -32.874 1.00 89.58 C \\\\nATOM 3361 C SER A 423 5.402 -24.609 -33.580 1.00 89.58 C \\\\nATOM 3362 CB SER A 423 3.834 -26.286 -32.505 1.00 89.58 C \\\\nATOM 3363 O SER A 423 6.389 -25.223 -33.179 1.00 89.58 O \\\\nATOM 3364 OG SER A 423 3.847 -27.096 -33.667 1.00 89.58 O \\\\nATOM 3365 N VAL A 424 5.430 -23.853 -34.686 1.00 86.04 N \\\\nATOM 3366 CA VAL A 424 6.582 -23.732 -35.608 1.00 86.04 C \\\\nATOM 3367 C VAL A 424 6.860 -22.279 -36.040 1.00 86.04 C \\\\nATOM 3368 CB VAL A 424 6.367 -24.626 -36.861 1.00 86.04 C \\\\nATOM 3369 O VAL A 424 7.895 -22.021 -36.645 1.00 86.04 O \\\\nATOM 3370 CG1 VAL A 424 7.640 -24.833 -37.700 1.00 86.04 C \\\\nATOM 3371 CG2 VAL A 424 5.872 -26.041 -36.507 1.00 86.04 C \\\\nATOM 3372 N SER A 425 5.935 -21.348 -35.773 1.00 67.52 N \\\\nATOM 3373 CA SER A 425 6.045 -19.920 -36.132 1.00 67.52 C \\\\nATOM 3374 C SER A 425 7.004 -19.152 -35.232 1.00 67.52 C \\\\nATOM 3375 CB SER A 425 4.678 -19.249 -36.048 1.00 67.52 C \\\\nATOM 3376 O SER A 425 6.854 -19.333 -34.002 1.00 67.52 O \\\\nATOM 3377 OG SER A 425 4.186 -19.498 -34.749 1.00 67.52 O \\\\nATOM 3378 OXT SER A 425 7.754 -18.328 -35.788 1.00 67.52 O \\\\nTER 3379 SER A 425 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 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'P84022_C394', 'P84022_C421'], 'hyperreactive_residues': [], 'ligandable_residues': [], 'is_act_site_residues': [], 'near_act_site_residues': [], 'is_bind_site_residues': ['P84022_C64', 'P84022_C109', 'P84022_C121'], 'near_bind_site_residues': [], 'near_act_site_neighbors': [], 'near_bind_site_neighbors': [], 'near_act_site_neighbors_per_residue': {}, 'near_bind_site_neighbors_per_residue': {}, 'has_any_flag': True, 'include_cysdb': True}}, 'labels': {1: 'MET1', 2: 'SER2', 3: 'SER3', 4: 'ILE4', 5: 'LEU5', 6: 'PRO6', 7: 'PHE7', 8: 'THR8', 9: 'PRO9', 10: 'PRO10', 11: 'ILE11', 12: 'VAL12', 13: 'LYS13', 14: 'ARG14', 15: 'LEU15', 16: 'LEU16', 17: 'GLY17', 18: 'TRP18', 19: 'LYS19', 20: 'LYS20', 21: 'GLY21', 22: 'GLU22', 23: 'GLN23', 24: 'ASN24', 25: 'GLY25', 26: 'GLN26', 27: 'GLU27', 28: 'GLU28', 29: 'LYS29', 30: 'TRP30', 31: 'CYS31', 32: 'GLU32', 33: 'LYS33', 34: 'ALA34', 35: 'VAL35', 36: 'LYS36', 37: 'SER37', 38: 'LEU38', 39: 'VAL39', 40: 'LYS40', 41: 'LYS41', 42: 'LEU42', 43: 'LYS43', 44: 'LYS44', 45: 'THR45', 46: 'GLY46', 47: 'GLN47', 48: 'LEU48', 49: 'ASP49', 50: 'GLU50', 51: 'LEU51', 52: 'GLU52', 53: 'LYS53', 54: 'ALA54', 55: 'ILE55', 56: 'THR56', 57: 'THR57', 58: 'GLN58', 59: 'ASN59', 60: 'VAL60', 61: 'ASN61', 62: 'THR62', 63: 'LYS63', 64: 'CYS64', 65: 'ILE65', 66: 'THR66', 67: 'ILE67', 68: 'PRO68', 69: 'ARG69', 70: 'SER70', 71: 'LEU71', 72: 'ASP72', 73: 'GLY73', 74: 'ARG74', 75: 'LEU75', 76: 'GLN76', 77: 'VAL77', 78: 'SER78', 79: 'HIS79', 80: 'ARG80', 81: 'LYS81', 82: 'GLY82', 83: 'LEU83', 84: 'PRO84', 85: 'HIS85', 86: 'VAL86', 87: 'ILE87', 88: 'TYR88', 89: 'CYS89', 90: 'ARG90', 91: 'LEU91', 92: 'TRP92', 93: 'ARG93', 94: 'TRP94', 95: 'PRO95', 96: 'ASP96', 97: 'LEU97', 98: 'HIS98', 99: 'SER99', 100: 'HIS100', 101: 'HIS101', 102: 'GLU102', 103: 'LEU103', 104: 'ARG104', 105: 'ALA105', 106: 'MET106', 107: 'GLU107', 108: 'LEU108', 109: 'CYS109', 110: 'GLU110', 111: 'PHE111', 112: 'ALA112', 113: 'PHE113', 114: 'ASN114', 115: 'MET115', 116: 'LYS116', 117: 'LYS117', 118: 'ASP118', 119: 'GLU119', 120: 'VAL120', 121: 'CYS121', 122: 'VAL122', 123: 'ASN123', 124: 'PRO124', 125: 'TYR125', 126: 'HIS126', 127: 'TYR127', 128: 'GLN128', 129: 'ARG129', 130: 'VAL130', 131: 'GLU131', 132: 'THR132', 133: 'PRO133', 134: 'VAL134', 135: 'LEU135', 136: 'PRO136', 137: 'PRO137', 138: 'VAL138', 139: 'LEU139', 140: 'VAL140', 141: 'PRO141', 142: 'ARG142', 143: 'HIS143', 144: 'THR144', 145: 'GLU145', 146: 'ILE146', 147: 'PRO147', 148: 'ALA148', 149: 'GLU149', 150: 'PHE150', 151: 'PRO151', 152: 'PRO152', 153: 'LEU153', 154: 'ASP154', 155: 'ASP155', 156: 'TYR156', 157: 'SER157', 158: 'HIS158', 159: 'SER159', 160: 'ILE160', 161: 'PRO161', 162: 'GLU162', 163: 'ASN163', 164: 'THR164', 165: 'ASN165', 166: 'PHE166', 167: 'PRO167', 168: 'ALA168', 169: 'GLY169', 170: 'ILE170', 171: 'GLU171', 172: 'PRO172', 173: 'GLN173', 174: 'SER174', 175: 'ASN175', 176: 'ILE176', 177: 'PRO177', 178: 'GLU178', 179: 'THR179', 180: 'PRO180', 181: 'PRO181', 182: 'PRO182', 183: 'GLY183', 184: 'TYR184', 185: 'LEU185', 186: 'SER186', 187: 'GLU187', 188: 'ASP188', 189: 'GLY189', 190: 'GLU190', 191: 'THR191', 192: 'SER192', 193: 'ASP193', 194: 'HIS194', 195: 'GLN195', 196: 'MET196', 197: 'ASN197', 198: 'HIS198', 199: 'SER199', 200: 'MET200', 201: 'ASP201', 202: 'ALA202', 203: 'GLY203', 204: 'SER204', 205: 'PRO205', 206: 'ASN206', 207: 'LEU207', 208: 'SER208', 209: 'PRO209', 210: 'ASN210', 211: 'PRO211', 212: 'MET212', 213: 'SER213', 214: 'PRO214', 215: 'ALA215', 216: 'HIS216', 217: 'ASN217', 218: 'ASN218', 219: 'LEU219', 220: 'ASP220', 221: 'LEU221', 222: 'GLN222', 223: 'PRO223', 224: 'VAL224', 225: 'THR225', 226: 'TYR226', 227: 'CYS227', 228: 'GLU228', 229: 'PRO229', 230: 'ALA230', 231: 'PHE231', 232: 'TRP232', 233: 'CYS233', 234: 'SER234', 235: 'ILE235', 236: 'SER236', 237: 'TYR237', 238: 'TYR238', 239: 'GLU239', 240: 'LEU240', 241: 'ASN241', 242: 'GLN242', 243: 'ARG243', 244: 'VAL244', 245: 'GLY245', 246: 'GLU246', 247: 'THR247', 248: 'PHE248', 249: 'HIS249', 250: 'ALA250', 251: 'SER251', 252: 'GLN252', 253: 'PRO253', 254: 'SER254', 255: 'MET255', 256: 'THR256', 257: 'VAL257', 258: 'ASP258', 259: 'GLY259', 260: 'PHE260', 261: 'THR261', 262: 'ASP262', 263: 'PRO263', 264: 'SER264', 265: 'ASN265', 266: 'SER266', 267: 'GLU267', 268: 'ARG268', 269: 'PHE269', 270: 'CYS270', 271: 'LEU271', 272: 'GLY272', 273: 'LEU273', 274: 'LEU274', 275: 'SER275', 276: 'ASN276', 277: 'VAL277', 278: 'ASN278', 279: 'ARG279', 280: 'ASN280', 281: 'ALA281', 282: 'ALA282', 283: 'VAL283', 284: 'GLU284', 285: 'LEU285', 286: 'THR286', 287: 'ARG287', 288: 'ARG288', 289: 'HIS289', 290: 'ILE290', 291: 'GLY291', 292: 'ARG292', 293: 'GLY293', 294: 'VAL294', 295: 'ARG295', 296: 'LEU296', 297: 'TYR297', 298: 'TYR298', 299: 'ILE299', 300: 'GLY300', 301: 'GLY301', 302: 'GLU302', 303: 'VAL303', 304: 'PHE304', 305: 'ALA305', 306: 'GLU306', 307: 'CYS307', 308: 'LEU308', 309: 'SER309', 310: 'ASP310', 311: 'SER311', 312: 'ALA312', 313: 'ILE313', 314: 'PHE314', 315: 'VAL315', 316: 'GLN316', 317: 'SER317', 318: 'PRO318', 319: 'ASN319', 320: 'CYS320', 321: 'ASN321', 322: 'GLN322', 323: 'ARG323', 324: 'TYR324', 325: 'GLY325', 326: 'TRP326', 327: 'HIS327', 328: 'PRO328', 329: 'ALA329', 330: 'THR330', 331: 'VAL331', 332: 'CYS332', 333: 'LYS333', 334: 'ILE334', 335: 'PRO335', 336: 'PRO336', 337: 'GLY337', 338: 'CYS338', 339: 'ASN339', 340: 'LEU340', 341: 'LYS341', 342: 'ILE342', 343: 'PHE343', 344: 'ASN344', 345: 'ASN345', 346: 'GLN346', 347: 'GLU347', 348: 'PHE348', 349: 'ALA349', 350: 'ALA350', 351: 'LEU351', 352: 'LEU352', 353: 'ALA353', 354: 'GLN354', 355: 'SER355', 356: 'VAL356', 357: 'ASN357', 358: 'GLN358', 359: 'GLY359', 360: 'PHE360', 361: 'GLU361', 362: 'ALA362', 363: 'VAL363', 364: 'TYR364', 365: 'GLN365', 366: 'LEU366', 367: 'THR367', 368: 'ARG368', 369: 'MET369', 370: 'CYS370', 371: 'THR371', 372: 'ILE372', 373: 'ARG373', 374: 'MET374', 375: 'SER375', 376: 'PHE376', 377: 'VAL377', 378: 'LYS378', 379: 'GLY379', 380: 'TRP380', 381: 'GLY381', 382: 'ALA382', 383: 'GLU383', 384: 'TYR384', 385: 'ARG385', 386: 'ARG386', 387: 'GLN387', 388: 'THR388', 389: 'VAL389', 390: 'THR390', 391: 'SER391', 392: 'THR392', 393: 'PRO393', 394: 'CYS394', 395: 'TRP395', 396: 'ILE396', 397: 'GLU397', 398: 'LEU398', 399: 'HIS399', 400: 'LEU400', 401: 'ASN401', 402: 'GLY402', 403: 'PRO403', 404: 'LEU404', 405: 'GLN405', 406: 'TRP406', 407: 'LEU407', 408: 'ASP408', 409: 'LYS409', 410: 'VAL410', 411: 'LEU411', 412: 'THR412', 413: 'GLN413', 414: 'MET414', 415: 'GLY415', 416: 'SER416', 417: 'PRO417', 418: 'SER418', 419: 'ILE419', 420: 'ARG420', 421: 'CYS421', 422: 'SER422', 423: 'SER423', 424: 'VAL424', 425: 'SER425'}}}}\\n[TOOL RUN] → chembl\\n[ChEMBL] Processing gene: SMAD2 @ 2025-12-24 19:13:03.329467\\n[ChEMBL] Processing gene: SMAD3 @ 2025-12-24 19:13:16.342572\\n*NAME* drug_central\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': ['SMAD2', 'SMAD3'], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id=None, ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=[], functions=[], diseases=[], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={}, nonhuman_interactions={}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={}, avg_exons_per_transcript=None, transcript_count=None, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'], tools_run=['EntityExtraction']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id=None, ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=[], functions=[], diseases=[], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={}, nonhuman_interactions={}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={}, avg_exons_per_transcript=None, transcript_count=None, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.'], tools_run=['EntityExtraction'])}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 0, 'used_tools': ['prot', 'chembl'], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID'], 'ui': {}, 'prot_html': '\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 2 (Q15796) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 467 UNP Q15796 SMAD2_HUMAN 1 467 \\\\nSEQRES 1 A 467 MET SER SER ILE LEU PRO PHE THR PRO PRO VAL VAL LYS \\\\nSEQRES 2 A 467 ARG LEU LEU GLY TRP LYS LYS SER ALA GLY GLY SER GLY \\\\nSEQRES 3 A 467 GLY ALA GLY GLY GLY GLU GLN ASN GLY GLN GLU GLU LYS \\\\nSEQRES 4 A 467 TRP CYS GLU LYS ALA VAL LYS SER LEU VAL LYS LYS LEU \\\\nSEQRES 5 A 467 LYS LYS THR GLY ARG LEU ASP GLU LEU GLU LYS ALA ILE \\\\nSEQRES 6 A 467 THR THR GLN ASN CYS ASN THR LYS CYS VAL THR ILE PRO \\\\nSEQRES 7 A 467 SER THR CYS SER GLU ILE TRP GLY LEU SER THR PRO ASN \\\\nSEQRES 8 A 467 THR ILE ASP GLN TRP ASP THR THR GLY LEU TYR SER PHE \\\\nSEQRES 9 A 467 SER GLU GLN THR ARG SER LEU ASP GLY ARG LEU GLN VAL \\\\nSEQRES 10 A 467 SER HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG \\\\nSEQRES 11 A 467 LEU TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU \\\\nSEQRES 12 A 467 LYS ALA ILE GLU ASN CYS GLU TYR ALA PHE ASN LEU LYS \\\\nSEQRES 13 A 467 LYS ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG \\\\nSEQRES 14 A 467 VAL GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG \\\\nSEQRES 15 A 467 HIS THR GLU ILE LEU THR GLU LEU PRO PRO LEU ASP ASP \\\\nSEQRES 16 A 467 TYR THR HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA \\\\nSEQRES 17 A 467 GLY ILE GLU PRO GLN SER ASN TYR ILE PRO GLU THR PRO \\\\nSEQRES 18 A 467 PRO PRO GLY TYR ILE SER GLU ASP GLY GLU THR SER ASP \\\\nSEQRES 19 A 467 GLN GLN LEU ASN GLN SER MET ASP THR GLY SER PRO ALA \\\\nSEQRES 20 A 467 GLU LEU SER PRO THR THR LEU SER PRO VAL ASN HIS SER \\\\nSEQRES 21 A 467 LEU ASP LEU GLN PRO VAL THR TYR SER GLU PRO ALA PHE \\\\nSEQRES 22 A 467 TRP CYS SER ILE ALA TYR TYR GLU LEU ASN GLN ARG VAL \\\\nSEQRES 23 A 467 GLY GLU THR PHE HIS ALA SER GLN PRO SER LEU THR VAL \\\\nSEQRES 24 A 467 ASP GLY PHE THR ASP PRO SER ASN SER GLU ARG PHE CYS \\\\nSEQRES 25 A 467 LEU GLY LEU LEU SER ASN VAL ASN ARG ASN ALA THR VAL \\\\nSEQRES 26 A 467 GLU MET THR ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU \\\\nSEQRES 27 A 467 TYR TYR ILE GLY GLY GLU VAL PHE ALA GLU CYS LEU SER \\\\nSEQRES 28 A 467 ASP SER ALA ILE PHE VAL GLN SER PRO ASN CYS ASN GLN \\\\nSEQRES 29 A 467 ARG TYR GLY TRP HIS PRO ALA THR VAL CYS LYS ILE PRO \\\\nSEQRES 30 A 467 PRO GLY CYS ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE \\\\nSEQRES 31 A 467 ALA ALA LEU LEU ALA GLN SER VAL ASN GLN GLY PHE GLU \\\\nSEQRES 32 A 467 ALA VAL TYR GLN LEU THR ARG MET CYS THR ILE ARG MET \\\\nSEQRES 33 A 467 SER PHE VAL LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN \\\\nSEQRES 34 A 467 THR VAL THR SER THR PRO CYS TRP ILE GLU LEU HIS LEU \\\\nSEQRES 35 A 467 ASN GLY PRO LEU GLN TRP LEU ASP LYS VAL LEU THR GLN \\\\nSEQRES 36 A 467 MET GLY SER PRO SER VAL ARG CYS SER SER MET SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 -24.572 -42.101 26.586 1.00 40.65 N \\\\nATOM 2 CA MET A 1 -23.660 -40.986 26.918 1.00 40.65 C \\\\nATOM 3 C MET A 1 -24.312 -39.697 26.444 1.00 40.65 C \\\\nATOM 4 CB MET A 1 -22.280 -41.179 26.264 1.00 40.65 C \\\\nATOM 5 O MET A 1 -24.227 -39.375 25.268 1.00 40.65 O \\\\nATOM 6 CG MET A 1 -21.477 -42.313 26.910 1.00 40.65 C \\\\nATOM 7 SD MET A 1 -19.880 -42.579 26.105 1.00 40.65 S \\\\nATOM 8 CE MET A 1 -19.199 -43.908 27.135 1.00 40.65 C \\\\nATOM 9 N SER A 2 -25.061 -39.026 27.318 1.00 40.07 N \\\\nATOM 10 CA SER A 2 -25.762 -37.787 26.974 1.00 40.07 C \\\\nATOM 11 C SER A 2 -24.744 -36.657 26.853 1.00 40.07 C \\\\nATOM 12 CB SER A 2 -26.833 -37.463 28.023 1.00 40.07 C \\\\nATOM 13 O SER A 2 -24.164 -36.225 27.847 1.00 40.07 O \\\\nATOM 14 OG SER A 2 -27.659 -38.600 28.207 1.00 40.07 O \\\\nATOM 15 N SER A 3 -24.488 -36.213 25.627 1.00 41.96 N \\\\nATOM 16 CA SER A 3 -23.669 -35.042 25.327 1.00 41.96 C \\\\nATOM 17 C SER A 3 -24.297 -33.802 25.968 1.00 41.96 C \\\\nATOM 18 CB SER A 3 -23.571 -34.885 23.804 1.00 41.96 C \\\\nATOM 19 O SER A 3 -25.347 -33.334 25.529 1.00 41.96 O \\\\nATOM 20 OG SER A 3 -24.856 -34.989 23.221 1.00 41.96 O \\\\nATOM 21 N ILE A 4 -23.663 -33.281 27.020 1.00 49.09 N \\\\nATOM 22 CA ILE A 4 -24.019 -32.004 27.645 1.00 49.09 C \\\\nATOM 23 C ILE A 4 -23.817 -30.914 26.587 1.00 49.09 C \\\\nATOM 24 CB ILE A 4 -23.162 -31.774 28.918 1.00 49.09 C \\\\nATOM 25 O ILE A 4 -22.683 -30.590 26.230 1.00 49.09 O \\\\nATOM 26 CG1 ILE A 4 -23.467 -32.865 29.975 1.00 49.09 C \\\\nATOM 27 CG2 ILE A 4 -23.401 -30.371 29.509 1.00 49.09 C \\\\nATOM 28 CD1 ILE A 4 -22.507 -32.870 31.172 1.00 49.09 C \\\\nATOM 29 N LEU A 5 -24.914 -30.374 26.051 1.00 54.35 N \\\\nATOM 30 CA LEU A 5 -24.866 -29.217 25.160 1.00 54.35 C \\\\nATOM 31 C LEU A 5 -24.174 -28.057 25.901 1.00 54.35 C \\\\nATOM 32 CB LEU A 5 -26.287 -28.820 24.715 1.00 54.35 C \\\\nATOM 33 O LEU A 5 -24.526 -27.781 27.052 1.00 54.35 O \\\\nATOM 34 CG LEU A 5 -26.968 -29.818 23.758 1.00 54.35 C \\\\nATOM 35 CD1 LEU A 5 -28.438 -29.436 23.583 1.00 54.35 C \\\\nATOM 36 CD2 LEU A 5 -26.309 -29.824 22.376 1.00 54.35 C \\\\nATOM 37 N PRO A 6 -23.190 -27.372 25.292 1.00 60.96 N \\\\nATOM 38 CA PRO A 6 -22.455 -26.309 25.964 1.00 60.96 C \\\\nATOM 39 C PRO A 6 -23.410 -25.182 26.380 1.00 60.96 C \\\\nATOM 40 CB PRO A 6 -21.373 -25.863 24.972 1.00 60.96 C \\\\nATOM 41 O PRO A 6 -24.093 -24.583 25.551 1.00 60.96 O \\\\nATOM 42 CG PRO A 6 -21.914 -26.299 23.609 1.00 60.96 C \\\\nATOM 43 CD PRO A 6 -22.720 -27.553 23.930 1.00 60.96 C \\\\nATOM 44 N PHE A 7 -23.456 -24.883 27.680 1.00 70.11 N \\\\nATOM 45 CA PHE A 7 -24.301 -23.825 28.228 1.00 70.11 C \\\\nATOM 46 C PHE A 7 -23.821 -22.449 27.741 1.00 70.11 C \\\\nATOM 47 CB PHE A 7 -24.316 -23.929 29.761 1.00 70.11 C \\\\nATOM 48 O PHE A 7 -22.785 -21.940 28.176 1.00 70.11 O \\\\nATOM 49 CG PHE A 7 -25.218 -22.917 30.448 1.00 70.11 C \\\\nATOM 50 CD1 PHE A 7 -24.682 -21.724 30.971 1.00 70.11 C \\\\nATOM 51 CD2 PHE A 7 -26.594 -23.180 30.586 1.00 70.11 C \\\\nATOM 52 CE1 PHE A 7 -25.515 -20.804 31.634 1.00 70.11 C \\\\nATOM 53 CE2 PHE A 7 -27.427 -22.259 31.246 1.00 70.11 C \\\\nATOM 54 CZ PHE A 7 -26.888 -21.073 31.773 1.00 70.11 C \\\\nATOM 55 N THR A 8 -24.572 -21.829 26.831 1.00 74.66 N \\\\nATOM 56 CA THR A 8 -24.329 -20.445 26.401 1.00 74.66 C \\\\nATOM 57 C THR A 8 -25.030 -19.480 27.363 1.00 74.66 C \\\\nATOM 58 CB THR A 8 -24.728 -20.221 24.936 1.00 74.66 C \\\\nATOM 59 O THR A 8 -26.260 -19.534 27.459 1.00 74.66 O \\\\nATOM 60 CG2 THR A 8 -24.478 -18.787 24.475 1.00 74.66 C \\\\nATOM 61 OG1 THR A 8 -23.883 -21.048 24.178 1.00 74.66 O \\\\nATOM 62 N PRO A 9 -24.291 -18.587 28.061 1.00 81.38 N \\\\nATOM 63 CA PRO A 9 -24.875 -17.665 29.034 1.00 81.38 C \\\\nATOM 64 C PRO A 9 -26.022 -16.833 28.430 1.00 81.38 C \\\\nATOM 65 CB PRO A 9 -23.725 -16.765 29.501 1.00 81.38 C \\\\nATOM 66 O PRO A 9 -25.880 -16.379 27.291 1.00 81.38 O \\\\nATOM 67 CG PRO A 9 -22.486 -17.630 29.288 1.00 81.38 C \\\\nATOM 68 CD PRO A 9 -22.839 -18.444 28.047 1.00 81.38 C \\\\nATOM 69 N PRO A 10 -27.113 -16.546 29.170 1.00 88.04 N \\\\nATOM 70 CA PRO A 10 -28.265 -15.803 28.643 1.00 88.04 C \\\\nATOM 71 C PRO A 10 -27.903 -14.455 28.006 1.00 88.04 C \\\\nATOM 72 CB PRO A 10 -29.206 -15.617 29.838 1.00 88.04 C \\\\nATOM 73 O PRO A 10 -28.428 -14.103 26.954 1.00 88.04 O \\\\nATOM 74 CG PRO A 10 -28.904 -16.831 30.714 1.00 88.04 C \\\\nATOM 75 CD PRO A 10 -27.408 -17.050 30.507 1.00 88.04 C \\\\nATOM 76 N VAL A 11 -26.942 -13.728 28.587 1.00 89.17 N \\\\nATOM 77 CA VAL A 11 -26.420 -12.472 28.018 1.00 89.17 C \\\\nATOM 78 C VAL A 11 -25.778 -12.654 26.641 1.00 89.17 C \\\\nATOM 79 CB VAL A 11 -25.444 -11.785 28.991 1.00 89.17 C \\\\nATOM 80 O VAL A 11 -25.989 -11.835 25.755 1.00 89.17 O \\\\nATOM 81 CG1 VAL A 11 -24.266 -12.670 29.436 1.00 89.17 C \\\\nATOM 82 CG2 VAL A 11 -24.874 -10.512 28.374 1.00 89.17 C \\\\nATOM 83 N VAL A 12 -25.047 -13.750 26.421 1.00 90.18 N \\\\nATOM 84 CA VAL A 12 -24.426 -14.037 25.121 1.00 90.18 C \\\\nATOM 85 C VAL A 12 -25.511 -14.301 24.081 1.00 90.18 C \\\\nATOM 86 CB VAL A 12 -23.450 -15.222 25.221 1.00 90.18 C \\\\nATOM 87 O VAL A 12 -25.415 -13.779 22.976 1.00 90.18 O \\\\nATOM 88 CG1 VAL A 12 -22.897 -15.653 23.860 1.00 90.18 C \\\\nATOM 89 CG2 VAL A 12 -22.261 -14.884 26.131 1.00 90.18 C \\\\nATOM 90 N LYS A 13 -26.567 -15.046 24.443 1.00 90.09 N \\\\nATOM 91 CA LYS A 13 -27.716 -15.269 23.551 1.00 90.09 C \\\\nATOM 92 C LYS A 13 -28.409 -13.955 23.179 1.00 90.09 C \\\\nATOM 93 CB LYS A 13 -28.730 -16.246 24.165 1.00 90.09 C \\\\nATOM 94 O LYS A 13 -28.685 -13.747 22.005 1.00 90.09 O \\\\nATOM 95 CG LYS A 13 -28.180 -17.668 24.349 1.00 90.09 C \\\\nATOM 96 CD LYS A 13 -29.318 -18.629 24.722 1.00 90.09 C \\\\nATOM 97 CE LYS A 13 -28.790 -20.054 24.924 1.00 90.09 C \\\\nATOM 98 NZ LYS A 13 -29.892 -21.005 25.223 1.00 90.09 N \\\\nATOM 99 N ARG A 14 -28.629 -13.054 24.148 1.00 91.11 N \\\\nATOM 100 CA ARG A 14 -29.205 -11.720 23.892 1.00 91.11 C \\\\nATOM 101 C ARG A 14 -28.332 -10.898 22.938 1.00 91.11 C \\\\nATOM 102 CB ARG A 14 -29.461 -10.958 25.206 1.00 91.11 C \\\\nATOM 103 O ARG A 14 -28.825 -10.440 21.917 1.00 91.11 O \\\\nATOM 104 CG ARG A 14 -30.632 -11.542 26.016 1.00 91.11 C \\\\nATOM 105 CD ARG A 14 -31.021 -10.655 27.210 1.00 91.11 C \\\\nATOM 106 NE ARG A 14 -29.967 -10.579 28.245 1.00 91.11 N \\\\nATOM 107 NH1 ARG A 14 -30.351 -8.417 28.976 1.00 91.11 N \\\\nATOM 108 NH2 ARG A 14 -28.636 -9.524 29.765 1.00 91.11 N \\\\nATOM 109 CZ ARG A 14 -29.674 -9.525 28.994 1.00 91.11 C \\\\nATOM 110 N LEU A 15 -27.028 -10.803 23.213 1.00 92.52 N \\\\nATOM 111 CA LEU A 15 -26.075 -10.061 22.377 1.00 92.52 C \\\\nATOM 112 C LEU A 15 -25.955 -10.606 20.948 1.00 92.52 C \\\\nATOM 113 CB LEU A 15 -24.703 -10.023 23.065 1.00 92.52 C \\\\nATOM 114 O LEU A 15 -25.822 -9.822 20.009 1.00 92.52 O \\\\nATOM 115 CG LEU A 15 -24.615 -9.069 24.270 1.00 92.52 C \\\\nATOM 116 CD1 LEU A 15 -23.259 -9.267 24.947 1.00 92.52 C \\\\nATOM 117 CD2 LEU A 15 -24.711 -7.596 23.880 1.00 92.52 C \\\\nATOM 118 N LEU A 16 -26.018 -11.929 20.780 1.00 91.58 N \\\\nATOM 119 CA LEU A 16 -26.069 -12.567 19.463 1.00 91.58 C \\\\nATOM 120 C LEU A 16 -27.408 -12.329 18.751 1.00 91.58 C \\\\nATOM 121 CB LEU A 16 -25.795 -14.073 19.608 1.00 91.58 C \\\\nATOM 122 O LEU A 16 -27.421 -12.254 17.529 1.00 91.58 O \\\\nATOM 123 CG LEU A 16 -24.336 -14.414 19.952 1.00 91.58 C \\\\nATOM 124 CD1 LEU A 16 -24.237 -15.887 20.345 1.00 91.58 C \\\\nATOM 125 CD2 LEU A 16 -23.386 -14.167 18.776 1.00 91.58 C \\\\nATOM 126 N GLY A 17 -28.506 -12.153 19.491 1.00 90.58 N \\\\nATOM 127 CA GLY A 17 -29.823 -11.820 18.939 1.00 90.58 C \\\\nATOM 128 C GLY A 17 -29.896 -10.443 18.269 1.00 90.58 C \\\\nATOM 129 O GLY A 17 -30.723 -10.244 17.387 1.00 90.58 O \\\\nATOM 130 N TRP A 18 -29.005 -9.510 18.625 1.00 91.39 N \\\\nATOM 131 CA TRP A 18 -28.865 -8.217 17.938 1.00 91.39 C \\\\nATOM 132 C TRP A 18 -27.843 -8.234 16.792 1.00 91.39 C \\\\nATOM 133 CB TRP A 18 -28.548 -7.112 18.953 1.00 91.39 C \\\\nATOM 134 O TRP A 18 -27.576 -7.184 16.202 1.00 91.39 O \\\\nATOM 135 CG TRP A 18 -29.603 -6.871 19.988 1.00 91.39 C \\\\nATOM 136 CD1 TRP A 18 -30.872 -6.473 19.747 1.00 91.39 C \\\\nATOM 137 CD2 TRP A 18 -29.499 -6.995 21.436 1.00 91.39 C \\\\nATOM 138 CE2 TRP A 18 -30.766 -6.701 22.015 1.00 91.39 C \\\\nATOM 139 CE3 TRP A 18 -28.444 -7.289 22.320 1.00 91.39 C \\\\nATOM 140 NE1 TRP A 18 -31.560 -6.364 20.941 1.00 91.39 N \\\\nATOM 141 CH2 TRP A 18 -29.924 -7.101 24.250 1.00 91.39 C \\\\nATOM 142 CZ2 TRP A 18 -30.987 -6.753 23.399 1.00 91.39 C \\\\nATOM 143 CZ3 TRP A 18 -28.652 -7.369 23.711 1.00 91.39 C \\\\nATOM 144 N LYS A 19 -27.241 -9.392 16.475 1.00 91.72 N \\\\nATOM 145 CA LYS A 19 -26.306 -9.514 15.351 1.00 91.72 C \\\\nATOM 146 C LYS A 19 -27.019 -9.139 14.049 1.00 91.72 C \\\\nATOM 147 CB LYS A 19 -25.718 -10.938 15.266 1.00 91.72 C \\\\nATOM 148 O LYS A 19 -28.107 -9.635 13.766 1.00 91.72 O \\\\nATOM 149 CG LYS A 19 -24.561 -11.002 14.256 1.00 91.72 C \\\\nATOM 150 CD LYS A 19 -23.988 -12.398 13.957 1.00 91.72 C \\\\nATOM 151 CE LYS A 19 -24.732 -13.086 12.796 1.00 91.72 C \\\\nATOM 152 NZ LYS A 19 -23.912 -14.127 12.109 1.00 91.72 N \\\\nATOM 153 N LYS A 20 -26.391 -8.297 13.232 1.00 89.42 N \\\\nATOM 154 CA LYS A 20 -26.866 -8.016 11.872 1.00 89.42 C \\\\nATOM 155 C LYS A 20 -26.457 -9.165 10.944 1.00 89.42 C \\\\nATOM 156 CB LYS A 20 -26.344 -6.646 11.412 1.00 89.42 C \\\\nATOM 157 O LYS A 20 -25.346 -9.681 11.042 1.00 89.42 O \\\\nATOM 158 CG LYS A 20 -26.864 -5.469 12.253 1.00 89.42 C \\\\nATOM 159 CD LYS A 20 -28.377 -5.244 12.136 1.00 89.42 C \\\\nATOM 160 CE LYS A 20 -28.752 -3.968 12.896 1.00 89.42 C \\\\nATOM 161 NZ LYS A 20 -30.202 -3.672 12.787 1.00 89.42 N \\\\nATOM 162 N SER A 21 -27.358 -9.582 10.060 1.00 76.73 N \\\\nATOM 163 CA SER A 21 -27.071 -10.613 9.052 1.00 76.73 C \\\\nATOM 164 C SER A 21 -26.585 -9.953 7.766 1.00 76.73 C \\\\nATOM 165 CB SER A 21 -28.301 -11.487 8.791 1.00 76.73 C \\\\nATOM 166 O SER A 21 -27.132 -8.922 7.375 1.00 76.73 O \\\\nATOM 167 OG SER A 21 -28.651 -12.154 9.990 1.00 76.73 O \\\\nATOM 168 N ALA A 22 -25.577 -10.531 7.110 1.00 64.94 N \\\\nATOM 169 CA ALA A 22 -25.187 -10.124 5.764 1.00 64.94 C \\\\nATOM 170 C ALA A 22 -26.336 -10.489 4.805 1.00 64.94 C \\\\nATOM 171 CB ALA A 22 -23.856 -10.800 5.410 1.00 64.94 C \\\\nATOM 172 O ALA A 22 -26.600 -11.663 4.556 1.00 64.94 O \\\\nATOM 173 N GLY A 23 -27.108 -9.492 4.371 1.00 48.74 N \\\\nATOM 174 CA GLY A 23 -28.290 -9.689 3.538 1.00 48.74 C \\\\nATOM 175 C GLY A 23 -27.919 -10.007 2.093 1.00 48.74 C \\\\nATOM 176 O GLY A 23 -27.514 -9.117 1.356 1.00 48.74 O \\\\nATOM 177 N GLY A 24 -28.113 -11.264 1.698 1.00 39.25 N \\\\nATOM 178 CA GLY A 24 -28.194 -11.733 0.318 1.00 39.25 C \\\\nATOM 179 C GLY A 24 -29.205 -12.877 0.266 1.00 39.25 C \\\\nATOM 180 O GLY A 24 -29.023 -13.914 0.899 1.00 39.25 O \\\\nATOM 181 N SER A 25 -30.318 -12.649 -0.416 1.00 33.12 N \\\\nATOM 182 CA SER A 25 -31.419 -13.586 -0.628 1.00 33.12 C \\\\nATOM 183 C SER A 25 -30.967 -14.913 -1.254 1.00 33.12 C \\\\nATOM 184 CB SER A 25 -32.416 -12.900 -1.572 1.00 33.12 C \\\\nATOM 185 O SER A 25 -30.346 -14.912 -2.309 1.00 33.12 O \\\\nATOM 186 OG SER A 25 -31.719 -12.289 -2.643 1.00 33.12 O \\\\nATOM 187 N GLY A 26 -31.363 -16.033 -0.638 1.00 28.12 N \\\\nATOM 188 CA GLY A 26 -31.713 -17.288 -1.318 1.00 28.12 C \\\\nATOM 189 C GLY A 26 -30.714 -17.865 -2.327 1.00 28.12 C \\\\nATOM 190 O GLY A 26 -31.011 -17.915 -3.514 1.00 28.12 O \\\\nATOM 191 N GLY A 27 -29.588 -18.400 -1.852 1.00 31.96 N \\\\nATOM 192 CA GLY A 27 -28.741 -19.320 -2.619 1.00 31.96 C \\\\nATOM 193 C GLY A 27 -28.473 -20.587 -1.809 1.00 31.96 C \\\\nATOM 194 O GLY A 27 -27.802 -20.534 -0.781 1.00 31.96 O \\\\nATOM 195 N ALA A 28 -29.004 -21.729 -2.247 1.00 35.83 N \\\\nATOM 196 CA ALA A 28 -29.006 -23.014 -1.534 1.00 35.83 C \\\\nATOM 197 C ALA A 28 -27.627 -23.724 -1.429 1.00 35.83 C \\\\nATOM 198 CB ALA A 28 -30.091 -23.891 -2.180 1.00 35.83 C \\\\nATOM 199 O ALA A 28 -27.569 -24.948 -1.371 1.00 35.83 O \\\\nATOM 200 N GLY A 29 -26.513 -22.981 -1.385 1.00 39.37 N \\\\nATOM 201 CA GLY A 29 -25.144 -23.526 -1.411 1.00 39.37 C \\\\nATOM 202 C GLY A 29 -24.241 -23.187 -0.213 1.00 39.37 C \\\\nATOM 203 O GLY A 29 -23.067 -23.534 -0.238 1.00 39.37 O \\\\nATOM 204 N GLY A 30 -24.737 -22.500 0.828 1.00 39.93 N \\\\nATOM 205 CA GLY A 30 -23.887 -21.862 1.859 1.00 39.93 C \\\\nATOM 206 C GLY A 30 -23.858 -22.484 3.267 1.00 39.93 C \\\\nATOM 207 O GLY A 30 -23.334 -21.854 4.188 1.00 39.93 O \\\\nATOM 208 N GLY A 31 -24.432 -23.674 3.480 1.00 42.15 N \\\\nATOM 209 CA GLY A 31 -24.710 -24.205 4.828 1.00 42.15 C \\\\nATOM 210 C GLY A 31 -23.492 -24.328 5.759 1.00 42.15 C \\\\nATOM 211 O GLY A 31 -23.576 -23.985 6.939 1.00 42.15 O \\\\nATOM 212 N GLU A 32 -22.342 -24.764 5.242 1.00 51.18 N \\\\nATOM 213 CA GLU A 32 -21.145 -24.982 6.069 1.00 51.18 C \\\\nATOM 214 C GLU A 32 -20.403 -23.684 6.416 1.00 51.18 C \\\\nATOM 215 CB GLU A 32 -20.194 -25.962 5.376 1.00 51.18 C \\\\nATOM 216 O GLU A 32 -19.970 -23.505 7.559 1.00 51.18 O \\\\nATOM 217 CG GLU A 32 -20.775 -27.382 5.322 1.00 51.18 C \\\\nATOM 218 CD GLU A 32 -19.740 -28.389 4.808 1.00 51.18 C \\\\nATOM 219 OE1 GLU A 32 -19.671 -29.487 5.403 1.00 51.18 O \\\\nATOM 220 OE2 GLU A 32 -19.012 -28.029 3.858 1.00 51.18 O \\\\nATOM 221 N GLN A 33 -20.293 -22.752 5.461 1.00 56.72 N \\\\nATOM 222 CA GLN A 33 -19.598 -21.478 5.677 1.00 56.72 C \\\\nATOM 223 C GLN A 33 -20.337 -20.610 6.701 1.00 56.72 C \\\\nATOM 224 CB GLN A 33 -19.417 -20.721 4.353 1.00 56.72 C \\\\nATOM 225 O GLN A 33 -19.711 -20.066 7.616 1.00 56.72 O \\\\nATOM 226 CG GLN A 33 -18.447 -21.436 3.398 1.00 56.72 C \\\\nATOM 227 CD GLN A 33 -18.143 -20.615 2.147 1.00 56.72 C \\\\nATOM 228 NE2 GLN A 33 -17.830 -21.246 1.038 1.00 56.72 N \\\\nATOM 229 OE1 GLN A 33 -18.163 -19.397 2.144 1.00 56.72 O \\\\nATOM 230 N ASN A 34 -21.671 -20.572 6.618 1.00 67.29 N \\\\nATOM 231 CA ASN A 34 -22.498 -19.839 7.573 1.00 67.29 C \\\\nATOM 232 C ASN A 34 -22.352 -20.414 8.999 1.00 67.29 C \\\\nATOM 233 CB ASN A 34 -23.947 -19.854 7.053 1.00 67.29 C \\\\nATOM 234 O ASN A 34 -22.158 -19.676 9.965 1.00 67.29 O \\\\nATOM 235 CG ASN A 34 -24.826 -18.811 7.724 1.00 67.29 C \\\\nATOM 236 ND2 ASN A 34 -26.122 -18.906 7.550 1.00 67.29 N \\\\nATOM 237 OD1 ASN A 34 -24.377 -17.899 8.394 1.00 67.29 O \\\\nATOM 238 N GLY A 35 -22.302 -21.746 9.141 1.00 76.97 N \\\\nATOM 239 CA GLY A 35 -22.104 -22.400 10.439 1.00 76.97 C \\\\nATOM 240 C GLY A 35 -20.735 -22.124 11.081 1.00 76.97 C \\\\nATOM 241 O GLY A 35 -20.624 -22.025 12.309 1.00 76.97 O \\\\nATOM 242 N GLN A 36 -19.672 -21.979 10.284 1.00 80.76 N \\\\nATOM 243 CA GLN A 36 -18.354 -21.600 10.805 1.00 80.76 C \\\\nATOM 244 C GLN A 36 -18.326 -20.136 11.266 1.00 80.76 C \\\\nATOM 245 CB GLN A 36 -17.275 -21.880 9.750 1.00 80.76 C \\\\nATOM 246 O GLN A 36 -17.717 -19.827 12.298 1.00 80.76 O \\\\nATOM 247 CG GLN A 36 -15.860 -21.709 10.331 1.00 80.76 C \\\\nATOM 248 CD GLN A 36 -14.756 -22.070 9.342 1.00 80.76 C \\\\nATOM 249 NE2 GLN A 36 -13.504 -22.038 9.743 1.00 80.76 N \\\\nATOM 250 OE1 GLN A 36 -14.971 -22.380 8.191 1.00 80.76 O \\\\nATOM 251 N GLU A 37 -18.996 -19.248 10.534 1.00 83.37 N \\\\nATOM 252 CA GLU A 37 -19.110 -17.836 10.887 1.00 83.37 C \\\\nATOM 253 C GLU A 37 -19.920 -17.630 12.171 1.00 83.37 C \\\\nATOM 254 CB GLU A 37 -19.705 -17.064 9.706 1.00 83.37 C \\\\nATOM 255 O GLU A 37 -19.465 -16.931 13.078 1.00 83.37 O \\\\nATOM 256 CG GLU A 37 -19.659 -15.560 9.998 1.00 83.37 C \\\\nATOM 257 CD GLU A 37 -20.107 -14.688 8.825 1.00 83.37 C \\\\nATOM 258 OE1 GLU A 37 -20.015 -13.455 9.018 1.00 83.37 O \\\\nATOM 259 OE2 GLU A 37 -20.523 -15.243 7.790 1.00 83.37 O \\\\nATOM 260 N GLU A 38 -21.059 -18.306 12.322 1.00 85.66 N \\\\nATOM 261 CA GLU A 38 -21.865 -18.251 13.546 1.00 85.66 C \\\\nATOM 262 C GLU A 38 -21.082 -18.708 14.781 1.00 85.66 C \\\\nATOM 263 CB GLU A 38 -23.114 -19.119 13.390 1.00 85.66 C \\\\nATOM 264 O GLU A 38 -21.068 -18.015 15.806 1.00 85.66 O \\\\nATOM 265 CG GLU A 38 -24.157 -18.467 12.474 1.00 85.66 C \\\\nATOM 266 CD GLU A 38 -25.460 -19.276 12.420 1.00 85.66 C \\\\nATOM 267 OE1 GLU A 38 -26.457 -18.690 11.946 1.00 85.66 O \\\\nATOM 268 OE2 GLU A 38 -25.466 -20.426 12.919 1.00 85.66 O \\\\nATOM 269 N LYS A 39 -20.345 -19.823 14.671 1.00 86.55 N \\\\nATOM 270 CA LYS A 39 -19.451 -20.302 15.740 1.00 86.55 C \\\\nATOM 271 C LYS A 39 -18.372 -19.274 16.081 1.00 86.55 C \\\\nATOM 272 CB LYS A 39 -18.795 -21.626 15.317 1.00 86.55 C \\\\nATOM 273 O LYS A 39 -17.981 -19.150 17.245 1.00 86.55 O \\\\nATOM 274 CG LYS A 39 -19.767 -22.812 15.382 1.00 86.55 C \\\\nATOM 275 CD LYS A 39 -19.109 -24.081 14.822 1.00 86.55 C \\\\nATOM 276 CE LYS A 39 -20.135 -25.219 14.776 1.00 86.55 C \\\\nATOM 277 NZ LYS A 39 -19.592 -26.445 14.136 1.00 86.55 N \\\\nATOM 278 N TRP A 40 -17.863 -18.545 15.089 1.00 88.25 N \\\\nATOM 279 CA TRP A 40 -16.889 -17.482 15.316 1.00 88.25 C \\\\nATOM 280 C TRP A 40 -17.515 -16.281 16.041 1.00 88.25 C \\\\nATOM 281 CB TRP A 40 -16.221 -17.086 13.997 1.00 88.25 C \\\\nATOM 282 O TRP A 40 -16.951 -15.825 17.040 1.00 88.25 O \\\\nATOM 283 CG TRP A 40 -15.165 -16.048 14.177 1.00 88.25 C \\\\nATOM 284 CD1 TRP A 40 -13.860 -16.285 14.429 1.00 88.25 C \\\\nATOM 285 CD2 TRP A 40 -15.322 -14.598 14.178 1.00 88.25 C \\\\nATOM 286 CE2 TRP A 40 -14.050 -14.013 14.456 1.00 88.25 C \\\\nATOM 287 CE3 TRP A 40 -16.408 -13.723 13.961 1.00 88.25 C \\\\nATOM 288 NE1 TRP A 40 -13.204 -15.089 14.630 1.00 88.25 N \\\\nATOM 289 CH2 TRP A 40 -14.955 -11.783 14.248 1.00 88.25 C \\\\nATOM 290 CZ2 TRP A 40 -13.857 -12.626 14.495 1.00 88.25 C \\\\nATOM 291 CZ3 TRP A 40 -16.226 -12.329 13.998 1.00 88.25 C \\\\nATOM 292 N CYS A 41 -18.700 -15.828 15.616 1.00 90.26 N \\\\nATOM 293 CA CYS A 41 -19.451 -14.756 16.275 1.00 90.26 C \\\\nATOM 294 C CYS A 41 -19.745 -15.096 17.741 1.00 90.26 C \\\\nATOM 295 CB CYS A 41 -20.771 -14.510 15.529 1.00 90.26 C \\\\nATOM 296 O CYS A 41 -19.511 -14.274 18.629 1.00 90.26 O \\\\nATOM 297 SG CYS A 41 -20.480 -13.830 13.874 1.00 90.26 S \\\\nATOM 298 N GLU A 42 -20.186 -16.325 18.023 1.00 90.51 N \\\\nATOM 299 CA GLU A 42 -20.450 -16.772 19.390 1.00 90.51 C \\\\nATOM 300 C GLU A 42 -19.185 -16.721 20.259 1.00 90.51 C \\\\nATOM 301 CB GLU A 42 -21.072 -18.176 19.365 1.00 90.51 C \\\\nATOM 302 O GLU A 42 -19.226 -16.228 21.390 1.00 90.51 O \\\\nATOM 303 CG GLU A 42 -21.423 -18.629 20.789 1.00 90.51 C \\\\nATOM 304 CD GLU A 42 -22.094 -19.999 20.874 1.00 90.51 C \\\\nATOM 305 OE1 GLU A 42 -22.668 -20.264 21.960 1.00 90.51 O \\\\nATOM 306 OE2 GLU A 42 -21.847 -20.845 20.000 1.00 90.51 O \\\\nATOM 307 N LYS A 43 -18.035 -17.168 19.737 1.00 89.89 N \\\\nATOM 308 CA LYS A 43 -16.750 -17.069 20.449 1.00 89.89 C \\\\nATOM 309 C LYS A 43 -16.331 -15.615 20.685 1.00 89.89 C \\\\nATOM 310 CB LYS A 43 -15.656 -17.823 19.682 1.00 89.89 C \\\\nATOM 311 O LYS A 43 -15.843 -15.308 21.776 1.00 89.89 O \\\\nATOM 312 CG LYS A 43 -15.801 -19.351 19.770 1.00 89.89 C \\\\nATOM 313 CD LYS A 43 -14.681 -20.010 18.954 1.00 89.89 C \\\\nATOM 314 CE LYS A 43 -14.843 -21.529 18.842 1.00 89.89 C \\\\nATOM 315 NZ LYS A 43 -13.695 -22.134 18.114 1.00 89.89 N \\\\nATOM 316 N ALA A 44 -16.529 -14.728 19.707 1.00 90.90 N \\\\nATOM 317 CA ALA A 44 -16.215 -13.304 19.832 1.00 90.90 C \\\\nATOM 318 C ALA A 44 -17.040 -12.649 20.951 1.00 90.90 C \\\\nATOM 319 CB ALA A 44 -16.439 -12.611 18.479 1.00 90.90 C \\\\nATOM 320 O ALA A 44 -16.475 -12.035 21.857 1.00 90.90 O \\\\nATOM 321 N VAL A 45 -18.359 -12.866 20.957 1.00 93.13 N \\\\nATOM 322 CA VAL A 45 -19.264 -12.328 21.985 1.00 93.13 C \\\\nATOM 323 C VAL A 45 -18.977 -12.940 23.359 1.00 93.13 C \\\\nATOM 324 CB VAL A 45 -20.738 -12.517 21.575 1.00 93.13 C \\\\nATOM 325 O VAL A 45 -18.897 -12.206 24.342 1.00 93.13 O \\\\nATOM 326 CG1 VAL A 45 -21.709 -12.028 22.656 1.00 93.13 C \\\\nATOM 327 CG2 VAL A 45 -21.050 -11.716 20.305 1.00 93.13 C \\\\nATOM 328 N LYS A 46 -18.734 -14.257 23.460 1.00 90.75 N \\\\nATOM 329 CA LYS A 46 -18.327 -14.904 24.727 1.00 90.75 C \\\\nATOM 330 C LYS A 46 -17.047 -14.284 25.295 1.00 90.75 C \\\\nATOM 331 CB LYS A 46 -18.140 -16.425 24.535 1.00 90.75 C \\\\nATOM 332 O LYS A 46 -16.974 -14.020 26.497 1.00 90.75 O \\\\nATOM 333 CG LYS A 46 -19.477 -17.178 24.493 1.00 90.75 C \\\\nATOM 334 CD LYS A 46 -19.334 -18.690 24.241 1.00 90.75 C \\\\nATOM 335 CE LYS A 46 -20.738 -19.316 24.203 1.00 90.75 C \\\\nATOM 336 NZ LYS A 46 -20.772 -20.741 23.784 1.00 90.75 N \\\\nATOM 337 N SER A 47 -16.056 -14.031 24.437 1.00 89.31 N \\\\nATOM 338 CA SER A 47 -14.799 -13.380 24.817 1.00 89.31 C \\\\nATOM 339 C SER A 47 -15.031 -11.948 25.303 1.00 89.31 C \\\\nATOM 340 CB SER A 47 -13.825 -13.406 23.636 1.00 89.31 C \\\\nATOM 341 O SER A 47 -14.521 -11.576 26.363 1.00 89.31 O \\\\nATOM 342 OG SER A 47 -12.541 -12.957 24.032 1.00 89.31 O \\\\nATOM 343 N LEU A 48 -15.863 -11.169 24.599 1.00 92.11 N \\\\nATOM 344 CA LEU A 48 -16.211 -9.811 25.014 1.00 92.11 C \\\\nATOM 345 C LEU A 48 -16.908 -9.789 26.372 1.00 92.11 C \\\\nATOM 346 CB LEU A 48 -17.112 -9.131 23.972 1.00 92.11 C \\\\nATOM 347 O LEU A 48 -16.472 -9.073 27.267 1.00 92.11 O \\\\nATOM 348 CG LEU A 48 -17.369 -7.649 24.313 1.00 92.11 C \\\\nATOM 349 CD1 LEU A 48 -16.103 -6.796 24.387 1.00 92.11 C \\\\nATOM 350 CD2 LEU A 48 -18.318 -7.034 23.304 1.00 92.11 C \\\\nATOM 351 N VAL A 49 -17.948 -10.606 26.555 1.00 92.83 N \\\\nATOM 352 CA VAL A 49 -18.707 -10.674 27.811 1.00 92.83 C \\\\nATOM 353 C VAL A 49 -17.786 -11.020 28.981 1.00 92.83 C \\\\nATOM 354 CB VAL A 49 -19.863 -11.686 27.690 1.00 92.83 C \\\\nATOM 355 O VAL A 49 -17.889 -10.408 30.042 1.00 92.83 O \\\\nATOM 356 CG1 VAL A 49 -20.549 -11.969 29.034 1.00 92.83 C \\\\nATOM 357 CG2 VAL A 49 -20.943 -11.156 26.741 1.00 92.83 C \\\\nATOM 358 N LYS A 50 -16.836 -11.949 28.798 1.00 89.33 N \\\\nATOM 359 CA LYS A 50 -15.842 -12.282 29.831 1.00 89.33 C \\\\nATOM 360 C LYS A 50 -14.967 -11.079 30.205 1.00 89.33 C \\\\nATOM 361 CB LYS A 50 -14.997 -13.479 29.361 1.00 89.33 C \\\\nATOM 362 O LYS A 50 -14.634 -10.933 31.378 1.00 89.33 O \\\\nATOM 363 CG LYS A 50 -14.066 -14.014 30.465 1.00 89.33 C \\\\nATOM 364 CD LYS A 50 -13.259 -15.231 29.984 1.00 89.33 C \\\\nATOM 365 CE LYS A 50 -12.365 -15.766 31.114 1.00 89.33 C \\\\nATOM 366 NZ LYS A 50 -11.588 -16.967 30.703 1.00 89.33 N \\\\nATOM 367 N LYS A 51 -14.597 -10.230 29.238 1.00 88.71 N \\\\nATOM 368 CA LYS A 51 -13.817 -9.003 29.480 1.00 88.71 C \\\\nATOM 369 C LYS A 51 -14.659 -7.919 30.158 1.00 88.71 C \\\\nATOM 370 CB LYS A 51 -13.192 -8.490 28.171 1.00 88.71 C \\\\nATOM 371 O LYS A 51 -14.231 -7.385 31.174 1.00 88.71 O \\\\nATOM 372 CG LYS A 51 -12.089 -9.419 27.637 1.00 88.71 C \\\\nATOM 373 CD LYS A 51 -11.479 -8.842 26.352 1.00 88.71 C \\\\nATOM 374 CE LYS A 51 -10.367 -9.752 25.816 1.00 88.71 C \\\\nATOM 375 NZ LYS A 51 -9.566 -9.062 24.772 1.00 88.71 N \\\\nATOM 376 N LEU A 52 -15.874 -7.662 29.674 1.00 92.02 N \\\\nATOM 377 CA LEU A 52 -16.737 -6.597 30.202 1.00 92.02 C \\\\nATOM 378 C LEU A 52 -17.308 -6.897 31.591 1.00 92.02 C \\\\nATOM 379 CB LEU A 52 -17.871 -6.289 29.216 1.00 92.02 C \\\\nATOM 380 O LEU A 52 -17.553 -5.970 32.358 1.00 92.02 O \\\\nATOM 381 CG LEU A 52 -17.411 -5.796 27.835 1.00 92.02 C \\\\nATOM 382 CD1 LEU A 52 -18.646 -5.450 27.015 1.00 92.02 C \\\\nATOM 383 CD2 LEU A 52 -16.510 -4.565 27.878 1.00 92.02 C \\\\nATOM 384 N LYS A 53 -17.466 -8.177 31.956 1.00 90.21 N \\\\nATOM 385 CA LYS A 53 -17.799 -8.568 33.336 1.00 90.21 C \\\\nATOM 386 C LYS A 53 -16.706 -8.190 34.335 1.00 90.21 C \\\\nATOM 387 CB LYS A 53 -18.079 -10.075 33.425 1.00 90.21 C \\\\nATOM 388 O LYS A 53 -17.027 -7.907 35.480 1.00 90.21 O \\\\nATOM 389 CG LYS A 53 -19.488 -10.416 32.930 1.00 90.21 C \\\\nATOM 390 CD LYS A 53 -19.791 -11.901 33.151 1.00 90.21 C \\\\nATOM 391 CE LYS A 53 -21.242 -12.185 32.753 1.00 90.21 C \\\\nATOM 392 NZ LYS A 53 -21.682 -13.518 33.232 1.00 90.21 N \\\\nATOM 393 N LYS A 54 -15.435 -8.178 33.916 1.00 86.28 N \\\\nATOM 394 CA LYS A 54 -14.317 -7.762 34.778 1.00 86.28 C \\\\nATOM 395 C LYS A 54 -14.244 -6.244 34.944 1.00 86.28 C \\\\nATOM 396 CB LYS A 54 -12.983 -8.291 34.238 1.00 86.28 C \\\\nATOM 397 O LYS A 54 -13.834 -5.789 36.000 1.00 86.28 O \\\\nATOM 398 CG LYS A 54 -12.859 -9.818 34.308 1.00 86.28 C \\\\nATOM 399 CD LYS A 54 -11.468 -10.222 33.806 1.00 86.28 C \\\\nATOM 400 CE LYS A 54 -11.221 -11.720 33.988 1.00 86.28 C \\\\nATOM 401 NZ LYS A 54 -9.779 -12.030 33.803 1.00 86.28 N \\\\nATOM 402 N THR A 55 -14.635 -5.479 33.922 1.00 85.96 N \\\\nATOM 403 CA THR A 55 -14.583 -4.005 33.936 1.00 85.96 C \\\\nATOM 404 C THR A 55 -15.893 -3.341 34.372 1.00 85.96 C \\\\nATOM 405 CB THR A 55 -14.146 -3.452 32.568 1.00 85.96 C \\\\nATOM 406 O THR A 55 -15.940 -2.122 34.496 1.00 85.96 O \\\\nATOM 407 CG2 THR A 55 -12.763 -3.949 32.150 1.00 85.96 C \\\\nATOM 408 OG1 THR A 55 -15.038 -3.846 31.547 1.00 85.96 O \\\\nATOM 409 N GLY A 56 -16.972 -4.108 34.575 1.00 88.71 N \\\\nATOM 410 CA GLY A 56 -18.290 -3.575 34.942 1.00 88.71 C \\\\nATOM 411 C GLY A 56 -18.988 -2.791 33.821 1.00 88.71 C \\\\nATOM 412 O GLY A 56 -19.892 -2.010 34.088 1.00 88.71 O \\\\nATOM 413 N ARG A 57 -18.578 -2.970 32.557 1.00 89.65 N \\\\nATOM 414 CA ARG A 57 -19.094 -2.215 31.392 1.00 89.65 C \\\\nATOM 415 C ARG A 57 -20.141 -2.977 30.570 1.00 89.65 C \\\\nATOM 416 CB ARG A 57 -17.914 -1.754 30.516 1.00 89.65 C \\\\nATOM 417 O ARG A 57 -20.518 -2.529 29.490 1.00 89.65 O \\\\nATOM 418 CG ARG A 57 -16.913 -0.808 31.193 1.00 89.65 C \\\\nATOM 419 CD ARG A 57 -17.510 0.564 31.522 1.00 89.65 C \\\\nATOM 420 NE ARG A 57 -16.465 1.467 32.040 1.00 89.65 N \\\\nATOM 421 NH1 ARG A 57 -17.446 3.467 31.478 1.00 89.65 N \\\\nATOM 422 NH2 ARG A 57 -15.450 3.456 32.477 1.00 89.65 N \\\\nATOM 423 CZ ARG A 57 -16.463 2.787 32.001 1.00 89.65 C \\\\nATOM 424 N LEU A 58 -20.583 -4.146 31.039 1.00 92.08 N \\\\nATOM 425 CA LEU A 58 -21.513 -5.006 30.299 1.00 92.08 C \\\\nATOM 426 C LEU A 58 -22.893 -4.354 30.123 1.00 92.08 C \\\\nATOM 427 CB LEU A 58 -21.603 -6.366 31.010 1.00 92.08 C \\\\nATOM 428 O LEU A 58 -23.426 -4.374 29.017 1.00 92.08 O \\\\nATOM 429 CG LEU A 58 -22.493 -7.403 30.296 1.00 92.08 C \\\\nATOM 430 CD1 LEU A 58 -21.978 -7.747 28.893 1.00 92.08 C \\\\nATOM 431 CD2 LEU A 58 -22.483 -8.687 31.132 1.00 92.08 C \\\\nATOM 432 N ASP A 59 -23.422 -3.728 31.174 1.00 92.16 N \\\\nATOM 433 CA ASP A 59 -24.736 -3.072 31.134 1.00 92.16 C \\\\nATOM 434 C ASP A 59 -24.733 -1.855 30.197 1.00 92.16 C \\\\nATOM 435 CB ASP A 59 -25.151 -2.655 32.554 1.00 92.16 C \\\\nATOM 436 O ASP A 59 -25.700 -1.618 29.476 1.00 92.16 O \\\\nATOM 437 CG ASP A 59 -25.249 -3.839 33.523 1.00 92.16 C \\\\nATOM 438 OD1 ASP A 59 -25.561 -4.960 33.061 1.00 92.16 O \\\\nATOM 439 OD2 ASP A 59 -24.929 -3.629 34.711 1.00 92.16 O \\\\nATOM 440 N GLU A 60 -23.615 -1.123 30.132 1.00 92.46 N \\\\nATOM 441 CA GLU A 60 -23.435 -0.012 29.188 1.00 92.46 C \\\\nATOM 442 C GLU A 60 -23.424 -0.503 27.732 1.00 92.46 C \\\\nATOM 443 CB GLU A 60 -22.143 0.763 29.502 1.00 92.46 C \\\\nATOM 444 O GLU A 60 -24.003 0.152 26.867 1.00 92.46 O \\\\nATOM 445 CG GLU A 60 -22.169 1.524 30.841 1.00 92.46 C \\\\nATOM 446 CD GLU A 60 -23.135 2.728 30.898 1.00 92.46 C \\\\nATOM 447 OE1 GLU A 60 -23.315 3.275 32.013 1.00 92.46 O \\\\nATOM 448 OE2 GLU A 60 -23.622 3.188 29.838 1.00 92.46 O \\\\nATOM 449 N LEU A 61 -22.840 -1.678 27.449 1.00 93.87 N \\\\nATOM 450 CA LEU A 61 -22.908 -2.284 26.114 1.00 93.87 C \\\\nATOM 451 C LEU A 61 -24.337 -2.705 25.755 1.00 93.87 C \\\\nATOM 452 CB LEU A 61 -21.944 -3.481 26.011 1.00 93.87 C \\\\nATOM 453 O LEU A 61 -24.794 -2.415 24.650 1.00 93.87 O \\\\nATOM 454 CG LEU A 61 -21.969 -4.148 24.618 1.00 93.87 C \\\\nATOM 455 CD1 LEU A 61 -21.420 -3.231 23.519 1.00 93.87 C \\\\nATOM 456 CD2 LEU A 61 -21.150 -5.433 24.618 1.00 93.87 C \\\\nATOM 457 N GLU A 62 -25.045 -3.378 26.668 1.00 93.54 N \\\\nATOM 458 CA GLU A 62 -26.443 -3.769 26.441 1.00 93.54 C \\\\nATOM 459 C GLU A 62 -27.325 -2.540 26.204 1.00 93.54 C \\\\nATOM 460 CB GLU A 62 -26.995 -4.589 27.621 1.00 93.54 C \\\\nATOM 461 O GLU A 62 -28.126 -2.525 25.266 1.00 93.54 O \\\\nATOM 462 CG GLU A 62 -26.402 -6.004 27.667 1.00 93.54 C \\\\nATOM 463 CD GLU A 62 -27.088 -6.953 28.667 1.00 93.54 C \\\\nATOM 464 OE1 GLU A 62 -26.574 -8.083 28.830 1.00 93.54 O \\\\nATOM 465 OE2 GLU A 62 -28.202 -6.695 29.181 1.00 93.54 O \\\\nATOM 466 N LYS A 63 -27.129 -1.479 26.994 1.00 93.28 N \\\\nATOM 467 CA LYS A 63 -27.811 -0.197 26.818 1.00 93.28 C \\\\nATOM 468 C LYS A 63 -27.486 0.430 25.467 1.00 93.28 C \\\\nATOM 469 CB LYS A 63 -27.437 0.728 27.983 1.00 93.28 C \\\\nATOM 470 O LYS A 63 -28.412 0.847 24.775 1.00 93.28 O \\\\nATOM 471 CG LYS A 63 -28.233 2.040 27.961 1.00 93.28 C \\\\nATOM 472 CD LYS A 63 -27.803 2.920 29.138 1.00 93.28 C \\\\nATOM 473 CE LYS A 63 -28.577 4.240 29.125 1.00 93.28 C \\\\nATOM 474 NZ LYS A 63 -28.150 5.106 30.250 1.00 93.28 N \\\\nATOM 475 N ALA A 64 -26.217 0.479 25.066 1.00 93.52 N \\\\nATOM 476 CA ALA A 64 -25.806 1.046 23.784 1.00 93.52 C \\\\nATOM 477 C ALA A 64 -26.443 0.309 22.596 1.00 93.52 C \\\\nATOM 478 CB ALA A 64 -24.277 1.032 23.700 1.00 93.52 C \\\\nATOM 479 O ALA A 64 -27.006 0.953 21.716 1.00 93.52 O \\\\nATOM 480 N ILE A 65 -26.426 -1.029 22.605 1.00 93.03 N \\\\nATOM 481 CA ILE A 65 -27.017 -1.851 21.537 1.00 93.03 C \\\\nATOM 482 C ILE A 65 -28.545 -1.735 21.510 1.00 93.03 C \\\\nATOM 483 CB ILE A 65 -26.532 -3.315 21.639 1.00 93.03 C \\\\nATOM 484 O ILE A 65 -29.130 -1.622 20.437 1.00 93.03 O \\\\nATOM 485 CG1 ILE A 65 -25.006 -3.390 21.390 1.00 93.03 C \\\\nATOM 486 CG2 ILE A 65 -27.264 -4.212 20.620 1.00 93.03 C \\\\nATOM 487 CD1 ILE A 65 -24.401 -4.746 21.764 1.00 93.03 C \\\\nATOM 488 N THR A 66 -29.194 -1.718 22.676 1.00 92.60 N \\\\nATOM 489 CA THR A 66 -30.662 -1.653 22.763 1.00 92.60 C \\\\nATOM 490 C THR A 66 -31.198 -0.273 22.379 1.00 92.60 C \\\\nATOM 491 CB THR A 66 -31.146 -2.028 24.174 1.00 92.60 C \\\\nATOM 492 O THR A 66 -32.177 -0.171 21.647 1.00 92.60 O \\\\nATOM 493 CG2 THR A 66 -32.667 -2.135 24.269 1.00 92.60 C \\\\nATOM 494 OG1 THR A 66 -30.633 -3.284 24.551 1.00 92.60 O \\\\nATOM 495 N THR A 67 -30.559 0.797 22.863 1.00 92.64 N \\\\nATOM 496 CA THR A 67 -31.003 2.185 22.623 1.00 92.64 C \\\\nATOM 497 C THR A 67 -30.495 2.773 21.314 1.00 92.64 C \\\\nATOM 498 CB THR A 67 -30.606 3.133 23.765 1.00 92.64 C \\\\nATOM 499 O THR A 67 -31.008 3.799 20.880 1.00 92.64 O \\\\nATOM 500 CG2 THR A 67 -31.188 2.700 25.110 1.00 92.64 C \\\\nATOM 501 OG1 THR A 67 -29.206 3.215 23.915 1.00 92.64 O \\\\nATOM 502 N GLN A 68 -29.488 2.148 20.700 1.00 91.97 N \\\\nATOM 503 CA GLN A 68 -28.839 2.620 19.478 1.00 91.97 C \\\\nATOM 504 C GLN A 68 -28.338 4.071 19.573 1.00 91.97 C \\\\nATOM 505 CB GLN A 68 -29.736 2.359 18.258 1.00 91.97 C \\\\nATOM 506 O GLN A 68 -28.393 4.832 18.609 1.00 91.97 O \\\\nATOM 507 CG GLN A 68 -30.251 0.912 18.216 1.00 91.97 C \\\\nATOM 508 CD GLN A 68 -30.759 0.500 16.843 1.00 91.97 C \\\\nATOM 509 NE2 GLN A 68 -31.744 -0.367 16.782 1.00 91.97 N \\\\nATOM 510 OE1 GLN A 68 -30.267 0.904 15.800 1.00 91.97 O \\\\nATOM 511 N ASN A 69 -27.872 4.466 20.760 1.00 89.65 N \\\\nATOM 512 CA ASN A 69 -27.577 5.856 21.090 1.00 89.65 C \\\\nATOM 513 C ASN A 69 -26.068 6.099 21.251 1.00 89.65 C \\\\nATOM 514 CB ASN A 69 -28.402 6.229 22.331 1.00 89.65 C \\\\nATOM 515 O ASN A 69 -25.402 5.468 22.080 1.00 89.65 O \\\\nATOM 516 CG ASN A 69 -28.392 7.714 22.640 1.00 89.65 C \\\\nATOM 517 ND2 ASN A 69 -29.345 8.179 23.410 1.00 89.65 N \\\\nATOM 518 OD1 ASN A 69 -27.539 8.474 22.219 1.00 89.65 O \\\\nATOM 519 N CYS A 70 -25.540 7.065 20.499 1.00 90.18 N \\\\nATOM 520 CA CYS A 70 -24.140 7.490 20.554 1.00 90.18 C \\\\nATOM 521 C CYS A 70 -23.754 8.189 21.873 1.00 90.18 C \\\\nATOM 522 CB CYS A 70 -23.859 8.383 19.337 1.00 90.18 C \\\\nATOM 523 O CYS A 70 -22.586 8.165 22.245 1.00 90.18 O \\\\nATOM 524 SG CYS A 70 -24.988 9.806 19.301 1.00 90.18 S \\\\nATOM 525 N ASN A 71 -24.720 8.727 22.625 1.00 91.25 N \\\\nATOM 526 CA ASN A 71 -24.501 9.393 23.918 1.00 91.25 C \\\\nATOM 527 C ASN A 71 -24.326 8.416 25.098 1.00 91.25 C \\\\nATOM 528 CB ASN A 71 -25.653 10.379 24.174 1.00 91.25 C \\\\nATOM 529 O ASN A 71 -24.219 8.830 26.252 1.00 91.25 O \\\\nATOM 530 CG ASN A 71 -25.709 11.485 23.138 1.00 91.25 C \\\\nATOM 531 ND2 ASN A 71 -26.879 11.845 22.666 1.00 91.25 N \\\\nATOM 532 OD1 ASN A 71 -24.702 12.045 22.745 1.00 91.25 O \\\\nATOM 533 N THR A 72 -24.336 7.107 24.840 1.00 92.41 N \\\\nATOM 534 CA THR A 72 -23.986 6.097 25.850 1.00 92.41 C \\\\nATOM 535 C THR A 72 -22.507 6.193 26.239 1.00 92.41 C \\\\nATOM 536 CB THR A 72 -24.354 4.682 25.377 1.00 92.41 C \\\\nATOM 537 O THR A 72 -21.696 6.758 25.505 1.00 92.41 O \\\\nATOM 538 CG2 THR A 72 -25.874 4.478 25.331 1.00 92.41 C \\\\nATOM 539 OG1 THR A 72 -23.835 4.411 24.093 1.00 92.41 O \\\\nATOM 540 N LYS A 73 -22.125 5.663 27.410 1.00 93.98 N \\\\nATOM 541 CA LYS A 73 -20.726 5.719 27.862 1.00 93.98 C \\\\nATOM 542 C LYS A 73 -19.822 4.856 26.976 1.00 93.98 C \\\\nATOM 543 CB LYS A 73 -20.611 5.312 29.339 1.00 93.98 C \\\\nATOM 544 O LYS A 73 -20.266 3.904 26.332 1.00 93.98 O \\\\nATOM 545 CG LYS A 73 -21.291 6.319 30.278 1.00 93.98 C \\\\nATOM 546 CD LYS A 73 -21.077 5.906 31.737 1.00 93.98 C \\\\nATOM 547 CE LYS A 73 -21.893 6.794 32.679 1.00 93.98 C \\\\nATOM 548 NZ LYS A 73 -21.996 6.174 34.021 1.00 93.98 N \\\\nATOM 549 N CYS A 74 -18.523 5.163 26.980 1.00 94.08 N \\\\nATOM 550 CA CYS A 74 -17.531 4.311 26.328 1.00 94.08 C \\\\nATOM 551 C CYS A 74 -17.552 2.905 26.948 1.00 94.08 C \\\\nATOM 552 CB CYS A 74 -16.129 4.936 26.412 1.00 94.08 C \\\\nATOM 553 O CYS A 74 -17.532 2.745 28.173 1.00 94.08 O \\\\nATOM 554 SG CYS A 74 -16.008 6.429 25.382 1.00 94.08 S \\\\nATOM 555 N VAL A 75 -17.562 1.888 26.088 1.00 94.76 N \\\\nATOM 556 CA VAL A 75 -17.382 0.483 26.468 1.00 94.76 C \\\\nATOM 557 C VAL A 75 -15.969 0.112 26.067 1.00 94.76 C \\\\nATOM 558 CB VAL A 75 -18.406 -0.431 25.770 1.00 94.76 C \\\\nATOM 559 O VAL A 75 -15.702 -0.009 24.878 1.00 94.76 O \\\\nATOM 560 CG1 VAL A 75 -18.184 -1.901 26.146 1.00 94.76 C \\\\nATOM 561 CG2 VAL A 75 -19.841 -0.057 26.150 1.00 94.76 C \\\\nATOM 562 N THR A 76 -15.059 -0.032 27.023 1.00 93.46 N \\\\nATOM 563 CA THR A 76 -13.633 -0.205 26.735 1.00 93.46 C \\\\nATOM 564 C THR A 76 -13.158 -1.636 26.965 1.00 93.46 C \\\\nATOM 565 CB THR A 76 -12.778 0.807 27.509 1.00 93.46 C \\\\nATOM 566 O THR A 76 -13.692 -2.372 27.801 1.00 93.46 O \\\\nATOM 567 CG2 THR A 76 -13.114 2.240 27.106 1.00 93.46 C \\\\nATOM 568 OG1 THR A 76 -12.960 0.698 28.899 1.00 93.46 O \\\\nATOM 569 N ILE A 77 -12.156 -2.050 26.189 1.00 90.10 N \\\\nATOM 570 CA ILE A 77 -11.353 -3.243 26.468 1.00 90.10 C \\\\nATOM 571 C ILE A 77 -9.863 -2.894 26.371 1.00 90.10 C \\\\nATOM 572 CB ILE A 77 -11.712 -4.433 25.550 1.00 90.10 C \\\\nATOM 573 O ILE A 77 -9.518 -2.003 25.590 1.00 90.10 O \\\\nATOM 574 CG1 ILE A 77 -11.311 -4.212 24.075 1.00 90.10 C \\\\nATOM 575 CG2 ILE A 77 -13.194 -4.824 25.678 1.00 90.10 C \\\\nATOM 576 CD1 ILE A 77 -11.446 -5.492 23.246 1.00 90.10 C \\\\nATOM 577 N PRO A 78 -8.974 -3.630 27.063 1.00 85.17 N \\\\nATOM 578 CA PRO A 78 -7.536 -3.446 26.912 1.00 85.17 C \\\\nATOM 579 C PRO A 78 -7.113 -3.584 25.447 1.00 85.17 C \\\\nATOM 580 CB PRO A 78 -6.879 -4.504 27.802 1.00 85.17 C \\\\nATOM 581 O PRO A 78 -7.439 -4.582 24.787 1.00 85.17 O \\\\nATOM 582 CG PRO A 78 -7.942 -4.768 28.866 1.00 85.17 C \\\\nATOM 583 CD PRO A 78 -9.253 -4.611 28.100 1.00 85.17 C \\\\nATOM 584 N SER A 79 -6.401 -2.580 24.949 1.00 71.62 N \\\\nATOM 585 CA SER A 79 -5.681 -2.636 23.687 1.00 71.62 C \\\\nATOM 586 C SER A 79 -4.462 -3.539 23.896 1.00 71.62 C \\\\nATOM 587 CB SER A 79 -5.308 -1.217 23.219 1.00 71.62 C \\\\nATOM 588 O SER A 79 -3.763 -3.440 24.900 1.00 71.62 O \\\\nATOM 589 OG SER A 79 -4.110 -0.770 23.807 1.00 71.62 O \\\\nATOM 590 N THR A 80 -4.172 -4.464 22.983 1.00 59.90 N \\\\nATOM 591 CA THR A 80 -2.960 -5.301 23.097 1.00 59.90 C \\\\nATOM 592 C THR A 80 -1.685 -4.537 22.707 1.00 59.90 C \\\\nATOM 593 CB THR A 80 -3.101 -6.618 22.320 1.00 59.90 C \\\\nATOM 594 O THR A 80 -0.674 -5.158 22.406 1.00 59.90 O \\\\nATOM 595 CG2 THR A 80 -4.223 -7.497 22.877 1.00 59.90 C \\\\nATOM 596 OG1 THR A 80 -3.398 -6.369 20.967 1.00 59.90 O \\\\nATOM 597 N CYS A 81 -1.736 -3.200 22.677 1.00 47.74 N \\\\nATOM 598 CA CYS A 81 -0.661 -2.323 22.214 1.00 47.74 C \\\\nATOM 599 C CYS A 81 0.280 -1.863 23.350 1.00 47.74 C \\\\nATOM 600 CB CYS A 81 -1.319 -1.126 21.503 1.00 47.74 C \\\\nATOM 601 O CYS A 81 1.355 -1.333 23.082 1.00 47.74 O \\\\nATOM 602 SG CYS A 81 -0.392 -0.705 20.001 1.00 47.74 S \\\\nATOM 603 N SER A 82 -0.104 -2.063 24.615 1.00 37.47 N \\\\nATOM 604 CA SER A 82 0.460 -1.334 25.764 1.00 37.47 C \\\\nATOM 605 C SER A 82 1.840 -1.773 26.281 1.00 37.47 C \\\\nATOM 606 CB SER A 82 -0.560 -1.324 26.906 1.00 37.47 C \\\\nATOM 607 O SER A 82 2.295 -1.221 27.273 1.00 37.47 O \\\\nATOM 608 OG SER A 82 -1.732 -0.678 26.466 1.00 37.47 O \\\\nATOM 609 N GLU A 83 2.556 -2.707 25.645 1.00 31.77 N \\\\nATOM 610 CA GLU A 83 3.882 -3.150 26.139 1.00 31.77 C \\\\nATOM 611 C GLU A 83 5.094 -2.591 25.370 1.00 31.77 C \\\\nATOM 612 CB GLU A 83 3.915 -4.680 26.315 1.00 31.77 C \\\\nATOM 613 O GLU A 83 6.224 -2.919 25.710 1.00 31.77 O \\\\nATOM 614 CG GLU A 83 3.294 -5.082 27.666 1.00 31.77 C \\\\nATOM 615 CD GLU A 83 3.256 -6.598 27.899 1.00 31.77 C \\\\nATOM 616 OE1 GLU A 83 2.828 -7.025 29.001 1.00 31.77 O \\\\nATOM 617 OE2 GLU A 83 3.452 -7.382 26.936 1.00 31.77 O \\\\nATOM 618 N ILE A 84 4.906 -1.712 24.376 1.00 36.42 N \\\\nATOM 619 CA ILE A 84 6.024 -1.180 23.555 1.00 36.42 C \\\\nATOM 620 C ILE A 84 6.279 0.324 23.782 1.00 36.42 C \\\\nATOM 621 CB ILE A 84 5.843 -1.596 22.072 1.00 36.42 C \\\\nATOM 622 O ILE A 84 7.289 0.856 23.338 1.00 36.42 O \\\\nATOM 623 CG1 ILE A 84 5.726 -3.139 21.977 1.00 36.42 C \\\\nATOM 624 CG2 ILE A 84 6.992 -1.116 21.162 1.00 36.42 C \\\\nATOM 625 CD1 ILE A 84 5.420 -3.649 20.568 1.00 36.42 C \\\\nATOM 626 N TRP A 85 5.426 1.014 24.546 1.00 34.71 N \\\\nATOM 627 CA TRP A 85 5.549 2.464 24.793 1.00 34.71 C \\\\nATOM 628 C TRP A 85 5.761 2.828 26.271 1.00 34.71 C \\\\nATOM 629 CB TRP A 85 4.381 3.188 24.113 1.00 34.71 C \\\\nATOM 630 O TRP A 85 5.601 3.981 26.669 1.00 34.71 O \\\\nATOM 631 CG TRP A 85 4.342 2.970 22.629 1.00 34.71 C \\\\nATOM 632 CD1 TRP A 85 3.536 2.101 21.977 1.00 34.71 C \\\\nATOM 633 CD2 TRP A 85 5.203 3.561 21.607 1.00 34.71 C \\\\nATOM 634 CE2 TRP A 85 4.849 3.004 20.342 1.00 34.71 C \\\\nATOM 635 CE3 TRP A 85 6.259 4.499 21.624 1.00 34.71 C \\\\nATOM 636 NE1 TRP A 85 3.833 2.116 20.628 1.00 34.71 N \\\\nATOM 637 CH2 TRP A 85 6.542 4.307 19.203 1.00 34.71 C \\\\nATOM 638 CZ2 TRP A 85 5.500 3.365 19.152 1.00 34.71 C \\\\nATOM 639 CZ3 TRP A 85 6.920 4.870 20.436 1.00 34.71 C \\\\nATOM 640 N GLY A 86 6.149 1.843 27.086 1.00 29.44 N \\\\nATOM 641 CA GLY A 86 6.509 2.026 28.486 1.00 29.44 C \\\\nATOM 642 C GLY A 86 7.871 2.694 28.626 1.00 29.44 C \\\\nATOM 643 O GLY A 86 8.901 2.051 28.456 1.00 29.44 O \\\\nATOM 644 N LEU A 87 7.829 3.989 28.932 1.00 30.48 N \\\\nATOM 645 CA LEU A 87 8.833 4.761 29.663 1.00 30.48 C \\\\nATOM 646 C LEU A 87 9.878 3.875 30.357 1.00 30.48 C \\\\nATOM 647 CB LEU A 87 8.064 5.590 30.711 1.00 30.48 C \\\\nATOM 648 O LEU A 87 9.633 3.302 31.418 1.00 30.48 O \\\\nATOM 649 CG LEU A 87 7.241 6.738 30.097 1.00 30.48 C \\\\nATOM 650 CD1 LEU A 87 6.038 7.073 30.977 1.00 30.48 C \\\\nATOM 651 CD2 LEU A 87 8.101 7.992 29.942 1.00 30.48 C \\\\nATOM 652 N SER A 88 11.063 3.814 29.760 1.00 25.22 N \\\\nATOM 653 CA SER A 88 12.293 3.451 30.440 1.00 25.22 C \\\\nATOM 654 C SER A 88 12.496 4.428 31.599 1.00 25.22 C \\\\nATOM 655 CB SER A 88 13.476 3.470 29.450 1.00 25.22 C \\\\nATOM 656 O SER A 88 12.966 5.549 31.422 1.00 25.22 O \\\\nATOM 657 OG SER A 88 13.191 4.184 28.252 1.00 25.22 O \\\\nATOM 658 N THR A 89 12.136 4.009 32.810 1.00 30.16 N \\\\nATOM 659 CA THR A 89 12.752 4.561 34.014 1.00 30.16 C \\\\nATOM 660 C THR A 89 14.230 4.167 33.984 1.00 30.16 C \\\\nATOM 661 CB THR A 89 12.091 4.035 35.295 1.00 30.16 C \\\\nATOM 662 O THR A 89 14.527 2.970 33.921 1.00 30.16 O \\\\nATOM 663 CG2 THR A 89 10.757 4.732 35.552 1.00 30.16 C \\\\nATOM 664 OG1 THR A 89 11.841 2.651 35.201 1.00 30.16 O \\\\nATOM 665 N PRO A 90 15.173 5.124 34.002 1.00 28.90 N \\\\nATOM 666 CA PRO A 90 16.584 4.803 34.088 1.00 28.90 C \\\\nATOM 667 C PRO A 90 16.835 4.377 35.529 1.00 28.90 C \\\\nATOM 668 CB PRO A 90 17.313 6.095 33.707 1.00 28.90 C \\\\nATOM 669 O PRO A 90 16.705 5.202 36.424 1.00 28.90 O \\\\nATOM 670 CG PRO A 90 16.362 7.203 34.168 1.00 28.90 C \\\\nATOM 671 CD PRO A 90 14.973 6.563 34.105 1.00 28.90 C \\\\nATOM 672 N ASN A 91 17.056 3.084 35.752 1.00 29.36 N \\\\nATOM 673 CA ASN A 91 17.805 2.494 36.867 1.00 29.36 C \\\\nATOM 674 C ASN A 91 17.425 1.019 36.949 1.00 29.36 C \\\\nATOM 675 CB ASN A 91 17.552 3.179 38.232 1.00 29.36 C \\\\nATOM 676 O ASN A 91 16.373 0.683 37.484 1.00 29.36 O \\\\nATOM 677 CG ASN A 91 18.396 4.431 38.428 1.00 29.36 C \\\\nATOM 678 ND2 ASN A 91 18.022 5.292 39.346 1.00 29.36 N \\\\nATOM 679 OD1 ASN A 91 19.401 4.654 37.771 1.00 29.36 O \\\\nATOM 680 N THR A 92 18.254 0.164 36.353 1.00 32.37 N \\\\nATOM 681 CA THR A 92 18.830 -1.072 36.920 1.00 32.37 C \\\\nATOM 682 C THR A 92 19.379 -1.865 35.730 1.00 32.37 C \\\\nATOM 683 CB THR A 92 17.909 -1.961 37.789 1.00 32.37 C \\\\nATOM 684 O THR A 92 18.694 -2.679 35.117 1.00 32.37 O \\\\nATOM 685 CG2 THR A 92 18.737 -3.005 38.536 1.00 32.37 C \\\\nATOM 686 OG1 THR A 92 17.303 -1.246 38.836 1.00 32.37 O \\\\nATOM 687 N ILE A 93 20.615 -1.541 35.349 1.00 28.03 N \\\\nATOM 688 CA ILE A 93 21.522 -2.503 34.722 1.00 28.03 C \\\\nATOM 689 C ILE A 93 21.924 -3.445 35.857 1.00 28.03 C \\\\nATOM 690 CB ILE A 93 22.731 -1.736 34.106 1.00 28.03 C \\\\nATOM 691 O ILE A 93 22.379 -2.948 36.879 1.00 28.03 O \\\\nATOM 692 CG1 ILE A 93 22.439 -1.434 32.620 1.00 28.03 C \\\\nATOM 693 CG2 ILE A 93 24.089 -2.445 34.256 1.00 28.03 C \\\\nATOM 694 CD1 ILE A 93 23.420 -0.446 31.969 1.00 28.03 C \\\\nATOM 695 N ASP A 94 21.669 -4.747 35.726 1.00 28.87 N \\\\nATOM 696 CA ASP A 94 22.699 -5.776 35.917 1.00 28.87 C \\\\nATOM 697 C ASP A 94 22.152 -7.210 35.825 1.00 28.87 C \\\\nATOM 698 CB ASP A 94 23.527 -5.601 37.216 1.00 28.87 C \\\\nATOM 699 O ASP A 94 21.021 -7.503 36.202 1.00 28.87 O \\\\nATOM 700 CG ASP A 94 24.797 -4.765 36.982 1.00 28.87 C \\\\nATOM 701 OD1 ASP A 94 25.372 -4.904 35.874 1.00 28.87 O \\\\nATOM 702 OD2 ASP A 94 25.229 -4.050 37.912 1.00 28.87 O \\\\nATOM 703 N GLN A 95 23.048 -8.084 35.356 1.00 28.34 N \\\\nATOM 704 CA GLN A 95 23.051 -9.550 35.431 1.00 28.34 C \\\\nATOM 705 C GLN A 95 22.244 -10.349 34.398 1.00 28.34 C \\\\nATOM 706 CB GLN A 95 22.909 -10.039 36.878 1.00 28.34 C \\\\nATOM 707 O GLN A 95 21.122 -10.808 34.592 1.00 28.34 O \\\\nATOM 708 CG GLN A 95 24.224 -9.778 37.628 1.00 28.34 C \\\\nATOM 709 CD GLN A 95 24.151 -10.082 39.115 1.00 28.34 C \\\\nATOM 710 NE2 GLN A 95 25.259 -9.974 39.813 1.00 28.34 N \\\\nATOM 711 OE1 GLN A 95 23.125 -10.391 39.695 1.00 28.34 O \\\\nATOM 712 N TRP A 96 22.942 -10.621 33.298 1.00 28.28 N \\\\nATOM 713 CA TRP A 96 22.775 -11.798 32.453 1.00 28.28 C \\\\nATOM 714 C TRP A 96 23.284 -13.016 33.228 1.00 28.28 C \\\\nATOM 715 CB TRP A 96 23.558 -11.586 31.132 1.00 28.28 C \\\\nATOM 716 O TRP A 96 24.493 -13.222 33.312 1.00 28.28 O \\\\nATOM 717 CG TRP A 96 24.418 -10.350 31.070 1.00 28.28 C \\\\nATOM 718 CD1 TRP A 96 23.944 -9.116 30.787 1.00 28.28 C \\\\nATOM 719 CD2 TRP A 96 25.832 -10.165 31.407 1.00 28.28 C \\\\nATOM 720 CE2 TRP A 96 26.137 -8.773 31.296 1.00 28.28 C \\\\nATOM 721 CE3 TRP A 96 26.882 -11.012 31.826 1.00 28.28 C \\\\nATOM 722 NE1 TRP A 96 24.950 -8.184 30.923 1.00 28.28 N \\\\nATOM 723 CH2 TRP A 96 28.435 -9.124 31.956 1.00 28.28 C \\\\nATOM 724 CZ2 TRP A 96 27.409 -8.249 31.563 1.00 28.28 C \\\\nATOM 725 CZ3 TRP A 96 28.169 -10.499 32.089 1.00 28.28 C \\\\nATOM 726 N ASP A 97 22.372 -13.816 33.783 1.00 30.80 N \\\\nATOM 727 CA ASP A 97 22.724 -15.109 34.364 1.00 30.80 C \\\\nATOM 728 C ASP A 97 22.295 -16.277 33.477 1.00 30.80 C \\\\nATOM 729 CB ASP A 97 22.293 -15.250 35.836 1.00 30.80 C \\\\nATOM 730 O ASP A 97 21.179 -16.376 32.964 1.00 30.80 O \\\\nATOM 731 CG ASP A 97 23.484 -15.319 36.808 1.00 30.80 C \\\\nATOM 732 OD1 ASP A 97 24.590 -15.712 36.366 1.00 30.80 O \\\\nATOM 733 OD2 ASP A 97 23.262 -15.039 38.003 1.00 30.80 O \\\\nATOM 734 N THR A 98 23.271 -17.153 33.269 1.00 31.38 N \\\\nATOM 735 CA THR A 98 23.314 -18.206 32.260 1.00 31.38 C \\\\nATOM 736 C THR A 98 22.985 -19.534 32.926 1.00 31.38 C \\\\nATOM 737 CB THR A 98 24.722 -18.229 31.618 1.00 31.38 C \\\\nATOM 738 O THR A 98 23.879 -20.339 33.113 1.00 31.38 O \\\\nATOM 739 CG2 THR A 98 24.846 -19.152 30.402 1.00 31.38 C \\\\nATOM 740 OG1 THR A 98 25.071 -16.945 31.158 1.00 31.38 O \\\\nATOM 741 N THR A 99 21.741 -19.796 33.338 1.00 33.23 N \\\\nATOM 742 CA THR A 99 21.313 -21.157 33.728 1.00 33.23 C \\\\nATOM 743 C THR A 99 19.787 -21.311 33.746 1.00 33.23 C \\\\nATOM 744 CB THR A 99 21.846 -21.623 35.107 1.00 33.23 C \\\\nATOM 745 O THR A 99 19.082 -20.562 34.402 1.00 33.23 O \\\\nATOM 746 CG2 THR A 99 23.257 -22.219 35.127 1.00 33.23 C \\\\nATOM 747 OG1 THR A 99 21.824 -20.599 36.064 1.00 33.23 O \\\\nATOM 748 N GLY A 100 19.296 -22.335 33.041 1.00 27.30 N \\\\nATOM 749 CA GLY A 100 18.237 -23.241 33.502 1.00 27.30 C \\\\nATOM 750 C GLY A 100 16.857 -22.696 33.906 1.00 27.30 C \\\\nATOM 751 O GLY A 100 16.671 -22.157 34.986 1.00 27.30 O \\\\nATOM 752 N LEU A 101 15.853 -23.125 33.132 1.00 27.46 N \\\\nATOM 753 CA LEU A 101 14.538 -23.565 33.627 1.00 27.46 C \\\\nATOM 754 C LEU A 101 13.613 -22.492 34.228 1.00 27.46 C \\\\nATOM 755 CB LEU A 101 14.733 -24.746 34.612 1.00 27.46 C \\\\nATOM 756 O LEU A 101 13.380 -22.483 35.428 1.00 27.46 O \\\\nATOM 757 CG LEU A 101 15.334 -26.022 34.005 1.00 27.46 C \\\\nATOM 758 CD1 LEU A 101 15.954 -26.888 35.100 1.00 27.46 C \\\\nATOM 759 CD2 LEU A 101 14.255 -26.838 33.290 1.00 27.46 C \\\\nATOM 760 N TYR A 102 12.916 -21.736 33.373 1.00 30.22 N \\\\nATOM 761 CA TYR A 102 11.531 -21.351 33.669 1.00 30.22 C \\\\nATOM 762 C TYR A 102 10.646 -21.485 32.430 1.00 30.22 C \\\\nATOM 763 CB TYR A 102 11.414 -19.976 34.345 1.00 30.22 C \\\\nATOM 764 O TYR A 102 10.863 -20.877 31.385 1.00 30.22 O \\\\nATOM 765 CG TYR A 102 11.474 -20.073 35.861 1.00 30.22 C \\\\nATOM 766 CD1 TYR A 102 10.316 -20.404 36.597 1.00 30.22 C \\\\nATOM 767 CD2 TYR A 102 12.702 -19.909 36.528 1.00 30.22 C \\\\nATOM 768 CE1 TYR A 102 10.395 -20.584 37.993 1.00 30.22 C \\\\nATOM 769 CE2 TYR A 102 12.789 -20.106 37.919 1.00 30.22 C \\\\nATOM 770 OH TYR A 102 11.715 -20.639 39.995 1.00 30.22 O \\\\nATOM 771 CZ TYR A 102 11.635 -20.446 38.653 1.00 30.22 C \\\\nATOM 772 N SER A 103 9.636 -22.332 32.579 1.00 24.84 N \\\\nATOM 773 CA SER A 103 8.519 -22.529 31.672 1.00 24.84 C \\\\nATOM 774 C SER A 103 7.653 -21.269 31.646 1.00 24.84 C \\\\nATOM 775 CB SER A 103 7.727 -23.752 32.167 1.00 24.84 C \\\\nATOM 776 O SER A 103 6.948 -20.964 32.604 1.00 24.84 O \\\\nATOM 777 OG SER A 103 7.608 -23.765 33.584 1.00 24.84 O \\\\nATOM 778 N PHE A 104 7.684 -20.532 30.536 1.00 27.44 N \\\\nATOM 779 CA PHE A 104 6.739 -19.449 30.283 1.00 27.44 C \\\\nATOM 780 C PHE A 104 5.822 -19.864 29.138 1.00 27.44 C \\\\nATOM 781 CB PHE A 104 7.459 -18.110 30.061 1.00 27.44 C \\\\nATOM 782 O PHE A 104 6.258 -20.127 28.023 1.00 27.44 O \\\\nATOM 783 CG PHE A 104 6.856 -16.986 30.884 1.00 27.44 C \\\\nATOM 784 CD1 PHE A 104 5.896 -16.119 30.327 1.00 27.44 C \\\\nATOM 785 CD2 PHE A 104 7.246 -16.822 32.227 1.00 27.44 C \\\\nATOM 786 CE1 PHE A 104 5.346 -15.083 31.105 1.00 27.44 C \\\\nATOM 787 CE2 PHE A 104 6.696 -15.788 33.004 1.00 27.44 C \\\\nATOM 788 CZ PHE A 104 5.749 -14.915 32.443 1.00 27.44 C \\\\nATOM 789 N SER A 105 4.533 -19.978 29.442 1.00 27.30 N \\\\nATOM 790 CA SER A 105 3.481 -20.297 28.485 1.00 27.30 C \\\\nATOM 791 C SER A 105 3.463 -19.278 27.338 1.00 27.30 C \\\\nATOM 792 CB SER A 105 2.141 -20.303 29.231 1.00 27.30 C \\\\nATOM 793 O SER A 105 3.019 -18.142 27.521 1.00 27.30 O \\\\nATOM 794 OG SER A 105 1.982 -19.098 29.958 1.00 27.30 O \\\\nATOM 795 N GLU A 106 3.917 -19.692 26.156 1.00 25.42 N \\\\nATOM 796 CA GLU A 106 3.860 -18.921 24.914 1.00 25.42 C \\\\nATOM 797 C GLU A 106 2.403 -18.745 24.448 1.00 25.42 C \\\\nATOM 798 CB GLU A 106 4.702 -19.607 23.823 1.00 25.42 C \\\\nATOM 799 O GLU A 106 1.842 -19.550 23.706 1.00 25.42 O \\\\nATOM 800 CG GLU A 106 6.214 -19.418 24.009 1.00 25.42 C \\\\nATOM 801 CD GLU A 106 7.009 -20.112 22.892 1.00 25.42 C \\\\nATOM 802 OE1 GLU A 106 7.955 -19.480 22.375 1.00 25.42 O \\\\nATOM 803 OE2 GLU A 106 6.631 -21.253 22.542 1.00 25.42 O \\\\nATOM 804 N GLN A 107 1.765 -17.653 24.872 1.00 28.28 N \\\\nATOM 805 CA GLN A 107 0.642 -17.059 24.146 1.00 28.28 C \\\\nATOM 806 C GLN A 107 1.187 -15.917 23.290 1.00 28.28 C \\\\nATOM 807 CB GLN A 107 -0.488 -16.621 25.098 1.00 28.28 C \\\\nATOM 808 O GLN A 107 1.437 -14.817 23.774 1.00 28.28 O \\\\nATOM 809 CG GLN A 107 -1.620 -17.657 25.091 1.00 28.28 C \\\\nATOM 810 CD GLN A 107 -2.763 -17.340 26.051 1.00 28.28 C \\\\nATOM 811 NE2 GLN A 107 -3.799 -18.150 26.062 1.00 28.28 N \\\\nATOM 812 OE1 GLN A 107 -2.782 -16.380 26.803 1.00 28.28 O \\\\nATOM 813 N THR A 108 1.370 -16.198 22.003 1.00 28.45 N \\\\nATOM 814 CA THR A 108 1.763 -15.256 20.948 1.00 28.45 C \\\\nATOM 815 C THR A 108 0.865 -14.004 20.952 1.00 28.45 C \\\\nATOM 816 CB THR A 108 1.719 -15.973 19.575 1.00 28.45 C \\\\nATOM 817 O THR A 108 -0.259 -14.024 20.446 1.00 28.45 O \\\\nATOM 818 CG2 THR A 108 3.096 -16.467 19.142 1.00 28.45 C \\\\nATOM 819 OG1 THR A 108 0.905 -17.134 19.580 1.00 28.45 O \\\\nATOM 820 N ARG A 109 1.351 -12.899 21.542 1.00 34.15 N \\\\nATOM 821 CA ARG A 109 0.684 -11.581 21.578 1.00 34.15 C \\\\nATOM 822 C ARG A 109 0.880 -10.832 20.252 1.00 34.15 C \\\\nATOM 823 CB ARG A 109 1.190 -10.740 22.773 1.00 34.15 C \\\\nATOM 824 O ARG A 109 1.962 -10.830 19.675 1.00 34.15 O \\\\nATOM 825 CG ARG A 109 0.662 -11.219 24.138 1.00 34.15 C \\\\nATOM 826 CD ARG A 109 1.170 -10.320 25.277 1.00 34.15 C \\\\nATOM 827 NE ARG A 109 0.667 -10.750 26.600 1.00 34.15 N \\\\nATOM 828 NH1 ARG A 109 1.439 -8.933 27.757 1.00 34.15 N \\\\nATOM 829 NH2 ARG A 109 0.374 -10.503 28.864 1.00 34.15 N \\\\nATOM 830 CZ ARG A 109 0.826 -10.067 27.724 1.00 34.15 C \\\\nATOM 831 N SER A 110 -0.182 -10.209 19.747 1.00 40.36 N \\\\nATOM 832 CA SER A 110 -0.188 -9.347 18.556 1.00 40.36 C \\\\nATOM 833 C SER A 110 0.285 -7.932 18.902 1.00 40.36 C \\\\nATOM 834 CB SER A 110 -1.599 -9.285 17.940 1.00 40.36 C \\\\nATOM 835 O SER A 110 -0.391 -7.226 19.647 1.00 40.36 O \\\\nATOM 836 OG SER A 110 -2.593 -9.587 18.901 1.00 40.36 O \\\\nATOM 837 N LEU A 111 1.410 -7.521 18.308 1.00 46.85 N \\\\nATOM 838 CA LEU A 111 2.098 -6.232 18.510 1.00 46.85 C \\\\nATOM 839 C LEU A 111 1.354 -5.012 17.914 1.00 46.85 C \\\\nATOM 840 CB LEU A 111 3.521 -6.342 17.906 1.00 46.85 C \\\\nATOM 841 O LEU A 111 1.835 -3.891 18.007 1.00 46.85 O \\\\nATOM 842 CG LEU A 111 4.412 -7.471 18.467 1.00 46.85 C \\\\nATOM 843 CD1 LEU A 111 5.636 -7.678 17.575 1.00 46.85 C \\\\nATOM 844 CD2 LEU A 111 4.914 -7.198 19.881 1.00 46.85 C \\\\nATOM 845 N ASP A 112 0.196 -5.213 17.281 1.00 55.73 N \\\\nATOM 846 CA ASP A 112 -0.514 -4.217 16.466 1.00 55.73 C \\\\nATOM 847 C ASP A 112 -1.930 -3.883 16.980 1.00 55.73 C \\\\nATOM 848 CB ASP A 112 -0.510 -4.692 15.001 1.00 55.73 C \\\\nATOM 849 O ASP A 112 -2.784 -3.407 16.231 1.00 55.73 O \\\\nATOM 850 CG ASP A 112 -1.314 -5.975 14.740 1.00 55.73 C \\\\nATOM 851 OD1 ASP A 112 -1.678 -6.702 15.700 1.00 55.73 O \\\\nATOM 852 OD2 ASP A 112 -1.580 -6.257 13.548 1.00 55.73 O \\\\nATOM 853 N GLY A 113 -2.224 -4.171 18.253 1.00 59.81 N \\\\nATOM 854 CA GLY A 113 -3.535 -3.895 18.857 1.00 59.81 C \\\\nATOM 855 C GLY A 113 -4.675 -4.818 18.389 1.00 59.81 C \\\\nATOM 856 O GLY A 113 -5.836 -4.599 18.750 1.00 59.81 O \\\\nATOM 857 N ARG A 114 -4.391 -5.854 17.582 1.00 63.47 N \\\\nATOM 858 CA ARG A 114 -5.409 -6.800 17.093 1.00 63.47 C \\\\nATOM 859 C ARG A 114 -5.798 -7.824 18.152 1.00 63.47 C \\\\nATOM 860 CB ARG A 114 -4.942 -7.495 15.809 1.00 63.47 C \\\\nATOM 861 O ARG A 114 -4.953 -8.455 18.775 1.00 63.47 O \\\\nATOM 862 CG ARG A 114 -4.841 -6.507 14.643 1.00 63.47 C \\\\nATOM 863 CD ARG A 114 -4.440 -7.238 13.362 1.00 63.47 C \\\\nATOM 864 NE ARG A 114 -4.171 -6.273 12.286 1.00 63.47 N \\\\nATOM 865 NH1 ARG A 114 -3.462 -7.784 10.712 1.00 63.47 N \\\\nATOM 866 NH2 ARG A 114 -3.261 -5.593 10.321 1.00 63.47 N \\\\nATOM 867 CZ ARG A 114 -3.634 -6.555 11.116 1.00 63.47 C \\\\nATOM 868 N LEU A 115 -7.096 -8.079 18.277 1.00 74.63 N \\\\nATOM 869 CA LEU A 115 -7.659 -9.174 19.058 1.00 74.63 C \\\\nATOM 870 C LEU A 115 -7.690 -10.461 18.228 1.00 74.63 C \\\\nATOM 871 CB LEU A 115 -9.063 -8.754 19.520 1.00 74.63 C \\\\nATOM 872 O LEU A 115 -8.206 -10.474 17.111 1.00 74.63 O \\\\nATOM 873 CG LEU A 115 -9.828 -9.795 20.351 1.00 74.63 C \\\\nATOM 874 CD1 LEU A 115 -9.130 -10.049 21.690 1.00 74.63 C \\\\nATOM 875 CD2 LEU A 115 -11.243 -9.286 20.637 1.00 74.63 C \\\\nATOM 876 N GLN A 116 -7.198 -11.560 18.799 1.00 75.91 N \\\\nATOM 877 CA GLN A 116 -7.332 -12.890 18.211 1.00 75.91 C \\\\nATOM 878 C GLN A 116 -8.573 -13.606 18.758 1.00 75.91 C \\\\nATOM 879 CB GLN A 116 -6.034 -13.680 18.419 1.00 75.91 C \\\\nATOM 880 O GLN A 116 -8.695 -13.840 19.961 1.00 75.91 O \\\\nATOM 881 CG GLN A 116 -6.031 -15.028 17.672 1.00 75.91 C \\\\nATOM 882 CD GLN A 116 -4.640 -15.661 17.623 1.00 75.91 C \\\\nATOM 883 NE2 GLN A 116 -4.521 -16.957 17.437 1.00 75.91 N \\\\nATOM 884 OE1 GLN A 116 -3.625 -14.996 17.701 1.00 75.91 O \\\\nATOM 885 N VAL A 117 -9.483 -13.994 17.865 1.00 72.04 N \\\\nATOM 886 CA VAL A 117 -10.655 -14.827 18.167 1.00 72.04 C \\\\nATOM 887 C VAL A 117 -10.622 -16.049 17.256 1.00 72.04 C \\\\nATOM 888 CB VAL A 117 -11.978 -14.051 17.996 1.00 72.04 C \\\\nATOM 889 O VAL A 117 -10.773 -15.928 16.043 1.00 72.04 O \\\\nATOM 890 CG1 VAL A 117 -13.165 -14.936 18.402 1.00 72.04 C \\\\nATOM 891 CG2 VAL A 117 -12.019 -12.777 18.849 1.00 72.04 C \\\\nATOM 892 N SER A 118 -10.434 -17.240 17.837 1.00 68.99 N \\\\nATOM 893 CA SER A 118 -10.448 -18.525 17.114 1.00 68.99 C \\\\nATOM 894 C SER A 118 -9.568 -18.523 15.851 1.00 68.99 C \\\\nATOM 895 CB SER A 118 -11.902 -18.925 16.820 1.00 68.99 C \\\\nATOM 896 O SER A 118 -10.045 -18.857 14.771 1.00 68.99 O \\\\nATOM 897 OG SER A 118 -12.005 -20.289 16.448 1.00 68.99 O \\\\nATOM 898 N HIS A 119 -8.298 -18.123 15.997 1.00 68.93 N \\\\nATOM 899 CA HIS A 119 -7.280 -17.992 14.933 1.00 68.93 C \\\\nATOM 900 C HIS A 119 -7.458 -16.828 13.945 1.00 68.93 C \\\\nATOM 901 CB HIS A 119 -7.038 -19.332 14.213 1.00 68.93 C \\\\nATOM 902 O HIS A 119 -6.550 -16.568 13.163 1.00 68.93 O \\\\nATOM 903 CG HIS A 119 -6.783 -20.471 15.161 1.00 68.93 C \\\\nATOM 904 CD2 HIS A 119 -7.722 -21.318 15.683 1.00 68.93 C \\\\nATOM 905 ND1 HIS A 119 -5.566 -20.833 15.692 1.00 68.93 N \\\\nATOM 906 CE1 HIS A 119 -5.772 -21.870 16.522 1.00 68.93 C \\\\nATOM 907 NE2 HIS A 119 -7.079 -22.174 16.576 1.00 68.93 N \\\\nATOM 908 N ARG A 120 -8.551 -16.058 14.018 1.00 73.52 N \\\\nATOM 909 CA ARG A 120 -8.704 -14.816 13.243 1.00 73.52 C \\\\nATOM 910 C ARG A 120 -8.238 -13.621 14.072 1.00 73.52 C \\\\nATOM 911 CB ARG A 120 -10.150 -14.654 12.750 1.00 73.52 C \\\\nATOM 912 O ARG A 120 -8.711 -13.441 15.194 1.00 73.52 O \\\\nATOM 913 CG ARG A 120 -10.598 -15.814 11.841 1.00 73.52 C \\\\nATOM 914 CD ARG A 120 -11.986 -15.551 11.237 1.00 73.52 C \\\\nATOM 915 NE ARG A 120 -12.393 -16.616 10.296 1.00 73.52 N \\\\nATOM 916 NH1 ARG A 120 -14.515 -15.835 9.841 1.00 73.52 N \\\\nATOM 917 NH2 ARG A 120 -13.766 -17.643 8.785 1.00 73.52 N \\\\nATOM 918 CZ ARG A 120 -13.550 -16.692 9.650 1.00 73.52 C \\\\nATOM 919 N LYS A 121 -7.316 -12.819 13.535 1.00 76.82 N \\\\nATOM 920 CA LYS A 121 -6.859 -11.555 14.138 1.00 76.82 C \\\\nATOM 921 C LYS A 121 -7.628 -10.391 13.514 1.00 76.82 C \\\\nATOM 922 CB LYS A 121 -5.338 -11.376 13.963 1.00 76.82 C \\\\nATOM 923 O LYS A 121 -7.679 -10.288 12.295 1.00 76.82 O \\\\nATOM 924 CG LYS A 121 -4.515 -12.378 14.792 1.00 76.82 C \\\\nATOM 925 CD LYS A 121 -3.003 -12.124 14.659 1.00 76.82 C \\\\nATOM 926 CE LYS A 121 -2.218 -13.100 15.552 1.00 76.82 C \\\\nATOM 927 NZ LYS A 121 -0.748 -12.887 15.486 1.00 76.82 N \\\\nATOM 928 N GLY A 122 -8.187 -9.507 14.332 1.00 81.47 N \\\\nATOM 929 CA GLY A 122 -8.886 -8.310 13.863 1.00 81.47 C \\\\nATOM 930 C GLY A 122 -8.894 -7.214 14.919 1.00 81.47 C \\\\nATOM 931 O GLY A 122 -8.692 -7.476 16.103 1.00 81.47 O \\\\nATOM 932 N LEU A 123 -9.103 -5.968 14.505 1.00 87.81 N \\\\nATOM 933 CA LEU A 123 -9.176 -4.849 15.442 1.00 87.81 C \\\\nATOM 934 C LEU A 123 -10.486 -4.927 16.247 1.00 87.81 C \\\\nATOM 935 CB LEU A 123 -9.035 -3.529 14.676 1.00 87.81 C \\\\nATOM 936 O LEU A 123 -11.540 -5.149 15.648 1.00 87.81 O \\\\nATOM 937 CG LEU A 123 -7.629 -3.315 14.083 1.00 87.81 C \\\\nATOM 938 CD1 LEU A 123 -7.642 -2.128 13.128 1.00 87.81 C \\\\nATOM 939 CD2 LEU A 123 -6.585 -3.067 15.172 1.00 87.81 C \\\\nATOM 940 N PRO A 124 -10.460 -4.748 17.583 1.00 91.18 N \\\\nATOM 941 CA PRO A 124 -11.645 -4.955 18.413 1.00 91.18 C \\\\nATOM 942 C PRO A 124 -12.867 -4.149 17.976 1.00 91.18 C \\\\nATOM 943 CB PRO A 124 -11.227 -4.558 19.825 1.00 91.18 C \\\\nATOM 944 O PRO A 124 -13.944 -4.708 17.804 1.00 91.18 O \\\\nATOM 945 CG PRO A 124 -9.724 -4.812 19.848 1.00 91.18 C \\\\nATOM 946 CD PRO A 124 -9.285 -4.515 18.417 1.00 91.18 C \\\\nATOM 947 N HIS A 125 -12.693 -2.846 17.760 1.00 92.35 N \\\\nATOM 948 CA HIS A 125 -13.778 -1.954 17.364 1.00 92.35 C \\\\nATOM 949 C HIS A 125 -14.386 -2.352 16.009 1.00 92.35 C \\\\nATOM 950 CB HIS A 125 -13.265 -0.512 17.371 1.00 92.35 C \\\\nATOM 951 O HIS A 125 -15.605 -2.341 15.875 1.00 92.35 O \\\\nATOM 952 CG HIS A 125 -12.171 -0.245 16.372 1.00 92.35 C \\\\nATOM 953 CD2 HIS A 125 -12.325 0.383 15.167 1.00 92.35 C \\\\nATOM 954 ND1 HIS A 125 -10.841 -0.590 16.492 1.00 92.35 N \\\\nATOM 955 CE1 HIS A 125 -10.216 -0.192 15.373 1.00 92.35 C \\\\nATOM 956 NE2 HIS A 125 -11.081 0.391 14.540 1.00 92.35 N \\\\nATOM 957 N VAL A 126 -13.568 -2.806 15.049 1.00 92.28 N \\\\nATOM 958 CA VAL A 126 -14.039 -3.320 13.750 1.00 92.28 C \\\\nATOM 959 C VAL A 126 -14.865 -4.590 13.928 1.00 92.28 C \\\\nATOM 960 CB VAL A 126 -12.871 -3.598 12.784 1.00 92.28 C \\\\nATOM 961 O VAL A 126 -15.959 -4.678 13.385 1.00 92.28 O \\\\nATOM 962 CG1 VAL A 126 -13.341 -4.074 11.404 1.00 92.28 C \\\\nATOM 963 CG2 VAL A 126 -12.036 -2.341 12.566 1.00 92.28 C \\\\nATOM 964 N ILE A 127 -14.385 -5.556 14.724 1.00 92.20 N \\\\nATOM 965 CA ILE A 127 -15.093 -6.826 14.975 1.00 92.20 C \\\\nATOM 966 C ILE A 127 -16.507 -6.566 15.506 1.00 92.20 C \\\\nATOM 967 CB ILE A 127 -14.283 -7.710 15.959 1.00 92.20 C \\\\nATOM 968 O ILE A 127 -17.475 -7.159 15.032 1.00 92.20 O \\\\nATOM 969 CG1 ILE A 127 -13.002 -8.244 15.276 1.00 92.20 C \\\\nATOM 970 CG2 ILE A 127 -15.144 -8.865 16.517 1.00 92.20 C \\\\nATOM 971 CD1 ILE A 127 -11.991 -8.869 16.249 1.00 92.20 C \\\\nATOM 972 N TYR A 128 -16.629 -5.678 16.490 1.00 94.45 N \\\\nATOM 973 CA TYR A 128 -17.897 -5.428 17.169 1.00 94.45 C \\\\nATOM 974 C TYR A 128 -18.826 -4.489 16.387 1.00 94.45 C \\\\nATOM 975 CB TYR A 128 -17.579 -4.936 18.580 1.00 94.45 C \\\\nATOM 976 O TYR A 128 -20.036 -4.712 16.376 1.00 94.45 O \\\\nATOM 977 CG TYR A 128 -16.888 -5.987 19.446 1.00 94.45 C \\\\nATOM 978 CD1 TYR A 128 -17.417 -7.286 19.612 1.00 94.45 C \\\\nATOM 979 CD2 TYR A 128 -15.647 -5.676 20.023 1.00 94.45 C \\\\nATOM 980 CE1 TYR A 128 -16.688 -8.263 20.326 1.00 94.45 C \\\\nATOM 981 CE2 TYR A 128 -14.923 -6.631 20.751 1.00 94.45 C \\\\nATOM 982 OH TYR A 128 -14.702 -8.853 21.570 1.00 94.45 O \\\\nATOM 983 CZ TYR A 128 -15.439 -7.932 20.894 1.00 94.45 C \\\\nATOM 984 N CYS A 129 -18.287 -3.513 15.647 1.00 94.84 N \\\\nATOM 985 CA CYS A 129 -19.075 -2.754 14.671 1.00 94.84 C \\\\nATOM 986 C CYS A 129 -19.608 -3.661 13.555 1.00 94.84 C \\\\nATOM 987 CB CYS A 129 -18.240 -1.615 14.078 1.00 94.84 C \\\\nATOM 988 O CYS A 129 -20.777 -3.539 13.185 1.00 94.84 O \\\\nATOM 989 SG CYS A 129 -17.923 -0.349 15.334 1.00 94.84 S \\\\nATOM 990 N ARG A 130 -18.794 -4.612 13.071 1.00 93.45 N \\\\nATOM 991 CA ARG A 130 -19.218 -5.591 12.064 1.00 93.45 C \\\\nATOM 992 C ARG A 130 -20.382 -6.446 12.561 1.00 93.45 C \\\\nATOM 993 CB ARG A 130 -18.024 -6.446 11.593 1.00 93.45 C \\\\nATOM 994 O ARG A 130 -21.346 -6.669 11.841 1.00 93.45 O \\\\nATOM 995 CG ARG A 130 -18.402 -7.345 10.401 1.00 93.45 C \\\\nATOM 996 CD ARG A 130 -17.297 -8.325 9.987 1.00 93.45 C \\\\nATOM 997 NE ARG A 130 -16.140 -7.643 9.388 1.00 93.45 N \\\\nATOM 998 NH1 ARG A 130 -14.894 -9.481 8.823 1.00 93.45 N \\\\nATOM 999 NH2 ARG A 130 -14.164 -7.456 8.280 1.00 93.45 N \\\\nATOM 1000 CZ ARG A 130 -15.073 -8.194 8.841 1.00 93.45 C \\\\nATOM 1001 N LEU A 131 -20.314 -6.886 13.817 1.00 93.42 N \\\\nATOM 1002 CA LEU A 131 -21.314 -7.774 14.406 1.00 93.42 C \\\\nATOM 1003 C LEU A 131 -22.680 -7.088 14.596 1.00 93.42 C \\\\nATOM 1004 CB LEU A 131 -20.719 -8.351 15.707 1.00 93.42 C \\\\nATOM 1005 O LEU A 131 -23.709 -7.687 14.289 1.00 93.42 O \\\\nATOM 1006 CG LEU A 131 -21.370 -9.671 16.157 1.00 93.42 C \\\\nATOM 1007 CD1 LEU A 131 -20.361 -10.540 16.910 1.00 93.42 C \\\\nATOM 1008 CD2 LEU A 131 -22.557 -9.466 17.093 1.00 93.42 C \\\\nATOM 1009 N TRP A 132 -22.702 -5.844 15.089 1.00 95.06 N \\\\nATOM 1010 CA TRP A 132 -23.948 -5.172 15.499 1.00 95.06 C \\\\nATOM 1011 C TRP A 132 -24.456 -4.081 14.555 1.00 95.06 C \\\\nATOM 1012 CB TRP A 132 -23.787 -4.636 16.926 1.00 95.06 C \\\\nATOM 1013 O TRP A 132 -25.597 -3.646 14.709 1.00 95.06 O \\\\nATOM 1014 CG TRP A 132 -23.688 -5.707 17.963 1.00 95.06 C \\\\nATOM 1015 CD1 TRP A 132 -24.630 -6.650 18.186 1.00 95.06 C \\\\nATOM 1016 CD2 TRP A 132 -22.612 -5.982 18.908 1.00 95.06 C \\\\nATOM 1017 CE2 TRP A 132 -22.962 -7.158 19.640 1.00 95.06 C \\\\nATOM 1018 CE3 TRP A 132 -21.388 -5.357 19.239 1.00 95.06 C \\\\nATOM 1019 NE1 TRP A 132 -24.209 -7.512 19.174 1.00 95.06 N \\\\nATOM 1020 CH2 TRP A 132 -20.887 -7.109 20.860 1.00 95.06 C \\\\nATOM 1021 CZ2 TRP A 132 -22.104 -7.738 20.579 1.00 95.06 C \\\\nATOM 1022 CZ3 TRP A 132 -20.553 -5.900 20.234 1.00 95.06 C \\\\nATOM 1023 N ARG A 133 -23.656 -3.624 13.585 1.00 93.80 N \\\\nATOM 1024 CA ARG A 133 -24.057 -2.527 12.688 1.00 93.80 C \\\\nATOM 1025 C ARG A 133 -23.903 -2.858 11.214 1.00 93.80 C \\\\nATOM 1026 CB ARG A 133 -23.327 -1.232 13.054 1.00 93.80 C \\\\nATOM 1027 O ARG A 133 -24.900 -2.799 10.502 1.00 93.80 O \\\\nATOM 1028 CG ARG A 133 -23.740 -0.768 14.456 1.00 93.80 C \\\\nATOM 1029 CD ARG A 133 -23.208 0.630 14.740 1.00 93.80 C \\\\nATOM 1030 NE ARG A 133 -23.885 1.638 13.906 1.00 93.80 N \\\\nATOM 1031 NH1 ARG A 133 -22.534 3.330 14.523 1.00 93.80 N \\\\nATOM 1032 NH2 ARG A 133 -24.172 3.753 13.078 1.00 93.80 N \\\\nATOM 1033 CZ ARG A 133 -23.534 2.902 13.829 1.00 93.80 C \\\\nATOM 1034 N TRP A 134 -22.698 -3.219 10.781 1.00 92.86 N \\\\nATOM 1035 CA TRP A 134 -22.355 -3.332 9.359 1.00 92.86 C \\\\nATOM 1036 C TRP A 134 -21.638 -4.658 9.065 1.00 92.86 C \\\\nATOM 1037 CB TRP A 134 -21.502 -2.122 8.961 1.00 92.86 C \\\\nATOM 1038 O TRP A 134 -20.412 -4.713 9.159 1.00 92.86 O \\\\nATOM 1039 CG TRP A 134 -22.128 -0.786 9.203 1.00 92.86 C \\\\nATOM 1040 CD1 TRP A 134 -23.200 -0.283 8.552 1.00 92.86 C \\\\nATOM 1041 CD2 TRP A 134 -21.717 0.237 10.155 1.00 92.86 C \\\\nATOM 1042 CE2 TRP A 134 -22.578 1.364 10.001 1.00 92.86 C \\\\nATOM 1043 CE3 TRP A 134 -20.693 0.326 11.122 1.00 92.86 C \\\\nATOM 1044 NE1 TRP A 134 -23.466 0.992 9.014 1.00 92.86 N \\\\nATOM 1045 CH2 TRP A 134 -21.345 2.608 11.666 1.00 92.86 C \\\\nATOM 1046 CZ2 TRP A 134 -22.397 2.543 10.734 1.00 92.86 C \\\\nATOM 1047 CZ3 TRP A 134 -20.518 1.495 11.882 1.00 92.86 C \\\\nATOM 1048 N PRO A 135 -22.366 -5.742 8.736 1.00 90.70 N \\\\nATOM 1049 CA PRO A 135 -21.776 -7.058 8.453 1.00 90.70 C \\\\nATOM 1050 C PRO A 135 -20.717 -7.044 7.344 1.00 90.70 C \\\\nATOM 1051 CB PRO A 135 -22.955 -7.949 8.049 1.00 90.70 C \\\\nATOM 1052 O PRO A 135 -19.789 -7.847 7.363 1.00 90.70 O \\\\nATOM 1053 CG PRO A 135 -24.131 -7.309 8.777 1.00 90.70 C \\\\nATOM 1054 CD PRO A 135 -23.817 -5.820 8.695 1.00 90.70 C \\\\nATOM 1055 N ASP A 136 -20.846 -6.097 6.421 1.00 86.88 N \\\\nATOM 1056 CA ASP A 136 -19.995 -5.838 5.263 1.00 86.88 C \\\\nATOM 1057 C ASP A 136 -18.812 -4.895 5.560 1.00 86.88 C \\\\nATOM 1058 CB ASP A 136 -20.896 -5.265 4.158 1.00 86.88 C \\\\nATOM 1059 O ASP A 136 -18.151 -4.428 4.642 1.00 86.88 O \\\\nATOM 1060 CG ASP A 136 -21.458 -3.882 4.516 1.00 86.88 C \\\\nATOM 1061 OD1 ASP A 136 -21.929 -3.679 5.663 1.00 86.88 O \\\\nATOM 1062 OD2 ASP A 136 -21.416 -2.979 3.656 1.00 86.88 O \\\\nATOM 1063 N LEU A 137 -18.537 -4.569 6.825 1.00 87.97 N \\\\nATOM 1064 CA LEU A 137 -17.401 -3.726 7.204 1.00 87.97 C \\\\nATOM 1065 C LEU A 137 -16.083 -4.498 7.075 1.00 87.97 C \\\\nATOM 1066 CB LEU A 137 -17.626 -3.275 8.656 1.00 87.97 C \\\\nATOM 1067 O LEU A 137 -15.883 -5.449 7.826 1.00 87.97 O \\\\nATOM 1068 CG LEU A 137 -16.543 -2.322 9.169 1.00 87.97 C \\\\nATOM 1069 CD1 LEU A 137 -16.738 -0.932 8.577 1.00 87.97 C \\\\nATOM 1070 CD2 LEU A 137 -16.615 -2.224 10.690 1.00 87.97 C \\\\nATOM 1071 N HIS A 138 -15.128 -4.080 6.248 1.00 80.97 N \\\\nATOM 1072 CA HIS A 138 -13.871 -4.808 6.009 1.00 80.97 C \\\\nATOM 1073 C HIS A 138 -12.685 -4.237 6.790 1.00 80.97 C \\\\nATOM 1074 CB HIS A 138 -13.578 -4.858 4.507 1.00 80.97 C \\\\nATOM 1075 O HIS A 138 -11.864 -4.998 7.313 1.00 80.97 O \\\\nATOM 1076 CG HIS A 138 -14.632 -5.637 3.769 1.00 80.97 C \\\\nATOM 1077 CD2 HIS A 138 -14.644 -6.985 3.527 1.00 80.97 C \\\\nATOM 1078 ND1 HIS A 138 -15.826 -5.137 3.311 1.00 80.97 N \\\\nATOM 1079 CE1 HIS A 138 -16.550 -6.158 2.830 1.00 80.97 C \\\\nATOM 1080 NE2 HIS A 138 -15.882 -7.311 2.973 1.00 80.97 N \\\\nATOM 1081 N SER A 139 -12.614 -2.912 6.917 1.00 83.17 N \\\\nATOM 1082 CA SER A 139 -11.460 -2.200 7.465 1.00 83.17 C \\\\nATOM 1083 C SER A 139 -11.837 -1.201 8.559 1.00 83.17 C \\\\nATOM 1084 CB SER A 139 -10.727 -1.495 6.323 1.00 83.17 C \\\\nATOM 1085 O SER A 139 -12.946 -0.681 8.615 1.00 83.17 O \\\\nATOM 1086 OG SER A 139 -9.516 -0.929 6.795 1.00 83.17 O \\\\nATOM 1087 N HIS A 140 -10.874 -0.881 9.425 1.00 86.11 N \\\\nATOM 1088 CA HIS A 140 -11.016 0.216 10.386 1.00 86.11 C \\\\nATOM 1089 C HIS A 140 -11.071 1.593 9.723 1.00 86.11 C \\\\nATOM 1090 CB HIS A 140 -9.873 0.183 11.399 1.00 86.11 C \\\\nATOM 1091 O HIS A 140 -11.634 2.512 10.302 1.00 86.11 O \\\\nATOM 1092 CG HIS A 140 -8.528 0.596 10.861 1.00 86.11 C \\\\nATOM 1093 CD2 HIS A 140 -7.865 1.738 11.215 1.00 86.11 C \\\\nATOM 1094 ND1 HIS A 140 -7.736 -0.065 9.944 1.00 86.11 N \\\\nATOM 1095 CE1 HIS A 140 -6.614 0.656 9.776 1.00 86.11 C \\\\nATOM 1096 NE2 HIS A 140 -6.642 1.752 10.548 1.00 86.11 N \\\\nATOM 1097 N HIS A 141 -10.518 1.731 8.516 1.00 83.95 N \\\\nATOM 1098 CA HIS A 141 -10.558 2.982 7.763 1.00 83.95 C \\\\nATOM 1099 C HIS A 141 -11.983 3.357 7.319 1.00 83.95 C \\\\nATOM 1100 CB HIS A 141 -9.626 2.852 6.557 1.00 83.95 C \\\\nATOM 1101 O HIS A 141 -12.252 4.526 7.079 1.00 83.95 O \\\\nATOM 1102 CG HIS A 141 -8.176 2.638 6.875 1.00 83.95 C \\\\nATOM 1103 CD2 HIS A 141 -7.388 1.619 6.415 1.00 83.95 C \\\\nATOM 1104 ND1 HIS A 141 -7.370 3.480 7.600 1.00 83.95 N \\\\nATOM 1105 CE1 HIS A 141 -6.130 2.966 7.596 1.00 83.95 C \\\\nATOM 1106 NE2 HIS A 141 -6.101 1.811 6.913 1.00 83.95 N \\\\nATOM 1107 N GLU A 142 -12.907 2.391 7.256 1.00 89.04 N \\\\nATOM 1108 CA GLU A 142 -14.330 2.634 6.979 1.00 89.04 C \\\\nATOM 1109 C GLU A 142 -15.081 3.182 8.203 1.00 89.04 C \\\\nATOM 1110 CB GLU A 142 -14.996 1.327 6.533 1.00 89.04 C \\\\nATOM 1111 O GLU A 142 -16.275 3.461 8.114 1.00 89.04 O \\\\nATOM 1112 CG GLU A 142 -14.534 0.776 5.184 1.00 89.04 C \\\\nATOM 1113 CD GLU A 142 -15.197 -0.587 4.961 1.00 89.04 C \\\\nATOM 1114 OE1 GLU A 142 -14.500 -1.600 5.214 1.00 89.04 O \\\\nATOM 1115 OE2 GLU A 142 -16.417 -0.627 4.667 1.00 89.04 O \\\\nATOM 1116 N LEU A 143 -14.414 3.318 9.354 1.00 92.20 N \\\\nATOM 1117 CA LEU A 143 -14.996 3.828 10.589 1.00 92.20 C \\\\nATOM 1118 C LEU A 143 -14.329 5.133 11.019 1.00 92.20 C \\\\nATOM 1119 CB LEU A 143 -14.878 2.787 11.713 1.00 92.20 C \\\\nATOM 1120 O LEU A 143 -13.109 5.228 11.135 1.00 92.20 O \\\\nATOM 1121 CG LEU A 143 -15.634 1.470 11.494 1.00 92.20 C \\\\nATOM 1122 CD1 LEU A 143 -15.407 0.591 12.728 1.00 92.20 C \\\\nATOM 1123 CD2 LEU A 143 -17.138 1.678 11.311 1.00 92.20 C \\\\nATOM 1124 N LYS A 144 -15.152 6.111 11.389 1.00 92.19 N \\\\nATOM 1125 CA LYS A 144 -14.738 7.329 12.086 1.00 92.19 C \\\\nATOM 1126 C LYS A 144 -15.326 7.324 13.491 1.00 92.19 C \\\\nATOM 1127 CB LYS A 144 -15.184 8.540 11.257 1.00 92.19 C \\\\nATOM 1128 O LYS A 144 -16.518 7.089 13.653 1.00 92.19 O \\\\nATOM 1129 CG LYS A 144 -14.603 9.851 11.803 1.00 92.19 C \\\\nATOM 1130 CD LYS A 144 -15.084 11.048 10.975 1.00 92.19 C \\\\nATOM 1131 CE LYS A 144 -14.518 12.350 11.557 1.00 92.19 C \\\\nATOM 1132 NZ LYS A 144 -15.052 13.546 10.857 1.00 92.19 N \\\\nATOM 1133 N ALA A 145 -14.516 7.560 14.518 1.00 93.48 N \\\\nATOM 1134 CA ALA A 145 -15.049 7.713 15.868 1.00 93.48 C \\\\nATOM 1135 C ALA A 145 -15.831 9.030 16.001 1.00 93.48 C \\\\nATOM 1136 CB ALA A 145 -13.917 7.608 16.883 1.00 93.48 C \\\\nATOM 1137 O ALA A 145 -15.466 10.033 15.386 1.00 93.48 O \\\\nATOM 1138 N ILE A 146 -16.892 9.026 16.808 1.00 93.88 N \\\\nATOM 1139 CA ILE A 146 -17.597 10.257 17.182 1.00 93.88 C \\\\nATOM 1140 C ILE A 146 -16.704 11.122 18.078 1.00 93.88 C \\\\nATOM 1141 CB ILE A 146 -18.961 9.968 17.849 1.00 93.88 C \\\\nATOM 1142 O ILE A 146 -15.877 10.599 18.826 1.00 93.88 O \\\\nATOM 1143 CG1 ILE A 146 -18.805 9.282 19.226 1.00 93.88 C \\\\nATOM 1144 CG2 ILE A 146 -19.859 9.172 16.883 1.00 93.88 C \\\\nATOM 1145 CD1 ILE A 146 -20.121 9.053 19.971 1.00 93.88 C \\\\nATOM 1146 N GLU A 147 -16.913 12.435 18.052 1.00 91.33 N \\\\nATOM 1147 CA GLU A 147 -16.085 13.403 18.790 1.00 91.33 C \\\\nATOM 1148 C GLU A 147 -16.111 13.177 20.310 1.00 91.33 C \\\\nATOM 1149 CB GLU A 147 -16.553 14.823 18.439 1.00 91.33 C \\\\nATOM 1150 O GLU A 147 -15.098 13.340 20.983 1.00 91.33 O \\\\nATOM 1151 CG GLU A 147 -16.354 15.112 16.940 1.00 91.33 C \\\\nATOM 1152 CD GLU A 147 -16.770 16.525 16.513 1.00 91.33 C \\\\nATOM 1153 OE1 GLU A 147 -16.509 16.831 15.328 1.00 91.33 O \\\\nATOM 1154 OE2 GLU A 147 -17.365 17.248 17.340 1.00 91.33 O \\\\nATOM 1155 N ASN A 148 -17.234 12.684 20.840 1.00 91.34 N \\\\nATOM 1156 CA ASN A 148 -17.417 12.424 22.271 1.00 91.34 C \\\\nATOM 1157 C ASN A 148 -16.788 11.098 22.750 1.00 91.34 C \\\\nATOM 1158 CB ASN A 148 -18.923 12.499 22.595 1.00 91.34 C \\\\nATOM 1159 O ASN A 148 -16.949 10.719 23.912 1.00 91.34 O \\\\nATOM 1160 CG ASN A 148 -19.535 13.868 22.344 1.00 91.34 C \\\\nATOM 1161 ND2 ASN A 148 -20.838 13.988 22.425 1.00 91.34 N \\\\nATOM 1162 OD1 ASN A 148 -18.871 14.846 22.065 1.00 91.34 O \\\\nATOM 1163 N CYS A 149 -16.116 10.339 21.876 1.00 93.59 N \\\\nATOM 1164 CA CYS A 149 -15.512 9.064 22.252 1.00 93.59 C \\\\nATOM 1165 C CYS A 149 -14.118 9.261 22.868 1.00 93.59 C \\\\nATOM 1166 CB CYS A 149 -15.482 8.123 21.045 1.00 93.59 C \\\\nATOM 1167 O CYS A 149 -13.117 9.411 22.171 1.00 93.59 O \\\\nATOM 1168 SG CYS A 149 -15.018 6.462 21.626 1.00 93.59 S \\\\nATOM 1169 N GLU A 150 -14.029 9.163 24.194 1.00 93.72 N \\\\nATOM 1170 CA GLU A 150 -12.774 9.344 24.940 1.00 93.72 C \\\\nATOM 1171 C GLU A 150 -11.730 8.236 24.711 1.00 93.72 C \\\\nATOM 1172 CB GLU A 150 -13.086 9.387 26.438 1.00 93.72 C \\\\nATOM 1173 O GLU A 150 -10.553 8.426 25.023 1.00 93.72 O \\\\nATOM 1174 CG GLU A 150 -13.967 10.569 26.859 1.00 93.72 C \\\\nATOM 1175 CD GLU A 150 -14.248 10.552 28.369 1.00 93.72 C \\\\nATOM 1176 OE1 GLU A 150 -14.711 11.592 28.878 1.00 93.72 O \\\\nATOM 1177 OE2 GLU A 150 -14.031 9.488 29.003 1.00 93.72 O \\\\nATOM 1178 N TYR A 151 -12.142 7.075 24.195 1.00 93.47 N \\\\nATOM 1179 CA TYR A 151 -11.293 5.890 23.995 1.00 93.47 C \\\\nATOM 1180 C TYR A 151 -11.321 5.414 22.538 1.00 93.47 C \\\\nATOM 1181 CB TYR A 151 -11.669 4.785 24.992 1.00 93.47 C \\\\nATOM 1182 O TYR A 151 -11.233 4.219 22.254 1.00 93.47 O \\\\nATOM 1183 CG TYR A 151 -11.472 5.166 26.442 1.00 93.47 C \\\\nATOM 1184 CD1 TYR A 151 -10.273 4.836 27.103 1.00 93.47 C \\\\nATOM 1185 CD2 TYR A 151 -12.494 5.844 27.131 1.00 93.47 C \\\\nATOM 1186 CE1 TYR A 151 -10.105 5.180 28.459 1.00 93.47 C \\\\nATOM 1187 CE2 TYR A 151 -12.315 6.225 28.472 1.00 93.47 C \\\\nATOM 1188 OH TYR A 151 -10.938 6.273 30.427 1.00 93.47 O \\\\nATOM 1189 CZ TYR A 151 -11.120 5.884 29.140 1.00 93.47 C \\\\nATOM 1190 N ALA A 152 -11.501 6.342 21.600 1.00 91.45 N \\\\nATOM 1191 CA ALA A 152 -11.484 6.039 20.179 1.00 91.45 C \\\\nATOM 1192 C ALA A 152 -10.160 5.383 19.747 1.00 91.45 C \\\\nATOM 1193 CB ALA A 152 -11.749 7.336 19.422 1.00 91.45 C \\\\nATOM 1194 O ALA A 152 -9.087 5.708 20.256 1.00 91.45 O \\\\nATOM 1195 N PHE A 153 -10.225 4.463 18.780 1.00 88.26 N \\\\nATOM 1196 CA PHE A 153 -9.057 3.704 18.316 1.00 88.26 C \\\\nATOM 1197 C PHE A 153 -7.881 4.587 17.858 1.00 88.26 C \\\\nATOM 1198 CB PHE A 153 -9.508 2.782 17.176 1.00 88.26 C \\\\nATOM 1199 O PHE A 153 -6.724 4.286 18.149 1.00 88.26 O \\\\nATOM 1200 CG PHE A 153 -8.366 2.037 16.511 1.00 88.26 C \\\\nATOM 1201 CD1 PHE A 153 -7.961 2.377 15.205 1.00 88.26 C \\\\nATOM 1202 CD2 PHE A 153 -7.685 1.024 17.212 1.00 88.26 C \\\\nATOM 1203 CE1 PHE A 153 -6.883 1.703 14.605 1.00 88.26 C \\\\nATOM 1204 CE2 PHE A 153 -6.613 0.347 16.607 1.00 88.26 C \\\\nATOM 1205 CZ PHE A 153 -6.213 0.684 15.303 1.00 88.26 C \\\\nATOM 1206 N ASN A 154 -8.167 5.704 17.189 1.00 84.98 N \\\\nATOM 1207 CA ASN A 154 -7.164 6.657 16.710 1.00 84.98 C \\\\nATOM 1208 C ASN A 154 -6.425 7.402 17.838 1.00 84.98 C \\\\nATOM 1209 CB ASN A 154 -7.825 7.648 15.730 1.00 84.98 C \\\\nATOM 1210 O ASN A 154 -5.341 7.921 17.585 1.00 84.98 O \\\\nATOM 1211 CG ASN A 154 -8.927 8.482 16.366 1.00 84.98 C \\\\nATOM 1212 ND2 ASN A 154 -9.030 9.748 16.048 1.00 84.98 N \\\\nATOM 1213 OD1 ASN A 154 -9.725 7.990 17.145 1.00 84.98 O \\\\nATOM 1214 N LEU A 155 -6.959 7.425 19.067 1.00 87.90 N \\\\nATOM 1215 CA LEU A 155 -6.299 8.036 20.228 1.00 87.90 C \\\\nATOM 1216 C LEU A 155 -5.151 7.181 20.790 1.00 87.90 C \\\\nATOM 1217 CB LEU A 155 -7.331 8.347 21.331 1.00 87.90 C \\\\nATOM 1218 O LEU A 155 -4.417 7.667 21.644 1.00 87.90 O \\\\nATOM 1219 CG LEU A 155 -8.442 9.332 20.931 1.00 87.90 C \\\\nATOM 1220 CD1 LEU A 155 -9.445 9.459 22.078 1.00 87.90 C \\\\nATOM 1221 CD2 LEU A 155 -7.894 10.724 20.616 1.00 87.90 C \\\\nATOM 1222 N LYS A 156 -4.992 5.926 20.330 1.00 83.25 N \\\\nATOM 1223 CA LYS A 156 -3.895 5.009 20.710 1.00 83.25 C \\\\nATOM 1224 C LYS A 156 -3.679 4.876 22.230 1.00 83.25 C \\\\nATOM 1225 CB LYS A 156 -2.595 5.394 19.979 1.00 83.25 C \\\\nATOM 1226 O LYS A 156 -2.548 4.755 22.690 1.00 83.25 O \\\\nATOM 1227 CG LYS A 156 -2.698 5.336 18.450 1.00 83.25 C \\\\nATOM 1228 CD LYS A 156 -1.342 5.712 17.841 1.00 83.25 C \\\\nATOM 1229 CE LYS A 156 -1.398 5.654 16.312 1.00 83.25 C \\\\nATOM 1230 NZ LYS A 156 -0.087 6.019 15.718 1.00 83.25 N \\\\nATOM 1231 N LYS A 157 -4.767 4.903 23.003 1.00 86.70 N \\\\nATOM 1232 CA LYS A 157 -4.747 4.689 24.457 1.00 86.70 C \\\\nATOM 1233 C LYS A 157 -4.578 3.207 24.801 1.00 86.70 C \\\\nATOM 1234 CB LYS A 157 -6.028 5.266 25.084 1.00 86.70 C \\\\nATOM 1235 O LYS A 157 -4.794 2.338 23.958 1.00 86.70 O \\\\nATOM 1236 CG LYS A 157 -6.087 6.797 24.984 1.00 86.70 C \\\\nATOM 1237 CD LYS A 157 -7.306 7.338 25.742 1.00 86.70 C \\\\nATOM 1238 CE LYS A 157 -7.300 8.869 25.738 1.00 86.70 C \\\\nATOM 1239 NZ LYS A 157 -8.459 9.409 26.489 1.00 86.70 N \\\\nATOM 1240 N ASP A 158 -4.286 2.931 26.072 1.00 86.03 N \\\\nATOM 1241 CA ASP A 158 -4.174 1.565 26.599 1.00 86.03 C \\\\nATOM 1242 C ASP A 158 -5.472 0.765 26.502 1.00 86.03 C \\\\nATOM 1243 CB ASP A 158 -3.732 1.605 28.067 1.00 86.03 C \\\\nATOM 1244 O ASP A 158 -5.446 -0.463 26.437 1.00 86.03 O \\\\nATOM 1245 CG ASP A 158 -2.309 2.127 28.218 1.00 86.03 C \\\\nATOM 1246 OD1 ASP A 158 -1.483 1.767 27.348 1.00 86.03 O \\\\nATOM 1247 OD2 ASP A 158 -2.084 2.884 29.182 1.00 86.03 O \\\\nATOM 1248 N GLU A 159 -6.611 1.447 26.423 1.00 90.02 N \\\\nATOM 1249 CA GLU A 159 -7.905 0.844 26.152 1.00 90.02 C \\\\nATOM 1250 C GLU A 159 -8.516 1.379 24.857 1.00 90.02 C \\\\nATOM 1251 CB GLU A 159 -8.876 1.060 27.310 1.00 90.02 C \\\\nATOM 1252 O GLU A 159 -8.314 2.531 24.473 1.00 90.02 O \\\\nATOM 1253 CG GLU A 159 -8.393 0.591 28.687 1.00 90.02 C \\\\nATOM 1254 CD GLU A 159 -9.585 0.508 29.654 1.00 90.02 C \\\\nATOM 1255 OE1 GLU A 159 -9.783 -0.580 30.240 1.00 90.02 O \\\\nATOM 1256 OE2 GLU A 159 -10.397 1.463 29.700 1.00 90.02 O \\\\nATOM 1257 N VAL A 160 -9.326 0.542 24.209 1.00 92.39 N \\\\nATOM 1258 CA VAL A 160 -10.071 0.894 22.997 1.00 92.39 C \\\\nATOM 1259 C VAL A 160 -11.570 0.743 23.224 1.00 92.39 C \\\\nATOM 1260 CB VAL A 160 -9.555 0.097 21.785 1.00 92.39 C \\\\nATOM 1261 O VAL A 160 -12.034 -0.267 23.762 1.00 92.39 O \\\\nATOM 1262 CG1 VAL A 160 -9.741 -1.423 21.908 1.00 92.39 C \\\\nATOM 1263 CG2 VAL A 160 -10.216 0.560 20.481 1.00 92.39 C \\\\nATOM 1264 N CYS A 161 -12.340 1.738 22.786 1.00 95.50 N \\\\nATOM 1265 CA CYS A 161 -13.791 1.693 22.797 1.00 95.50 C \\\\nATOM 1266 C CYS A 161 -14.298 0.686 21.760 1.00 95.50 C \\\\nATOM 1267 CB CYS A 161 -14.386 3.086 22.558 1.00 95.50 C \\\\nATOM 1268 O CYS A 161 -13.922 0.727 20.589 1.00 95.50 O \\\\nATOM 1269 SG CYS A 161 -16.167 3.003 22.908 1.00 95.50 S \\\\nATOM 1270 N VAL A 162 -15.186 -0.203 22.184 1.00 94.95 N \\\\nATOM 1271 CA VAL A 162 -15.862 -1.212 21.362 1.00 94.95 C \\\\nATOM 1272 C VAL A 162 -17.372 -0.992 21.289 1.00 94.95 C \\\\nATOM 1273 CB VAL A 162 -15.524 -2.631 21.842 1.00 94.95 C \\\\nATOM 1274 O VAL A 162 -18.089 -1.851 20.781 1.00 94.95 O \\\\nATOM 1275 CG1 VAL A 162 -14.031 -2.924 21.651 1.00 94.95 C \\\\nATOM 1276 CG2 VAL A 162 -15.898 -2.904 23.300 1.00 94.95 C \\\\nATOM 1277 N ASN A 163 -17.863 0.148 21.786 1.00 95.41 N \\\\nATOM 1278 CA ASN A 163 -19.251 0.553 21.605 1.00 95.41 C \\\\nATOM 1279 C ASN A 163 -19.493 0.835 20.110 1.00 95.41 C \\\\nATOM 1280 CB ASN A 163 -19.545 1.782 22.483 1.00 95.41 C \\\\nATOM 1281 O ASN A 163 -18.922 1.790 19.579 1.00 95.41 O \\\\nATOM 1282 CG ASN A 163 -20.991 2.243 22.403 1.00 95.41 C \\\\nATOM 1283 ND2 ASN A 163 -21.418 3.024 23.364 1.00 95.41 N \\\\nATOM 1284 OD1 ASN A 163 -21.735 1.892 21.496 1.00 95.41 O \\\\nATOM 1285 N PRO A 164 -20.333 0.052 19.411 1.00 94.93 N \\\\nATOM 1286 CA PRO A 164 -20.509 0.213 17.974 1.00 94.93 C \\\\nATOM 1287 C PRO A 164 -21.177 1.545 17.590 1.00 94.93 C \\\\nATOM 1288 CB PRO A 164 -21.316 -1.015 17.552 1.00 94.93 C \\\\nATOM 1289 O PRO A 164 -21.033 1.986 16.452 1.00 94.93 O \\\\nATOM 1290 CG PRO A 164 -22.135 -1.362 18.793 1.00 94.93 C \\\\nATOM 1291 CD PRO A 164 -21.163 -1.033 19.920 1.00 94.93 C \\\\nATOM 1292 N TYR A 165 -21.868 2.218 18.518 1.00 95.74 N \\\\nATOM 1293 CA TYR A 165 -22.497 3.531 18.306 1.00 95.74 C \\\\nATOM 1294 C TYR A 165 -21.555 4.711 18.578 1.00 95.74 C \\\\nATOM 1295 CB TYR A 165 -23.792 3.622 19.123 1.00 95.74 C \\\\nATOM 1296 O TYR A 165 -21.940 5.860 18.384 1.00 95.74 O \\\\nATOM 1297 CG TYR A 165 -24.828 2.636 18.631 1.00 95.74 C \\\\nATOM 1298 CD1 TYR A 165 -25.656 2.982 17.546 1.00 95.74 C \\\\nATOM 1299 CD2 TYR A 165 -24.897 1.347 19.187 1.00 95.74 C \\\\nATOM 1300 CE1 TYR A 165 -26.551 2.039 17.010 1.00 95.74 C \\\\nATOM 1301 CE2 TYR A 165 -25.770 0.394 18.630 1.00 95.74 C \\\\nATOM 1302 OH TYR A 165 -27.473 -0.173 17.044 1.00 95.74 O \\\\nATOM 1303 CZ TYR A 165 -26.611 0.741 17.555 1.00 95.74 C \\\\nATOM 1304 N HIS A 166 -20.311 4.438 18.983 1.00 96.55 N \\\\nATOM 1305 CA HIS A 166 -19.236 5.436 19.062 1.00 96.55 C \\\\nATOM 1306 C HIS A 166 -18.425 5.553 17.774 1.00 96.55 C \\\\nATOM 1307 CB HIS A 166 -18.339 5.141 20.265 1.00 96.55 C \\\\nATOM 1308 O HIS A 166 -17.483 6.337 17.705 1.00 96.55 O \\\\nATOM 1309 CG HIS A 166 -18.963 5.469 21.593 1.00 96.55 C \\\\nATOM 1310 CD2 HIS A 166 -20.246 5.881 21.816 1.00 96.55 C \\\\nATOM 1311 ND1 HIS A 166 -18.243 5.555 22.785 1.00 96.55 N \\\\nATOM 1312 CE1 HIS A 166 -19.104 6.056 23.681 1.00 96.55 C \\\\nATOM 1313 NE2 HIS A 166 -20.313 6.236 23.137 1.00 96.55 N \\\\nATOM 1314 N TYR A 167 -18.809 4.800 16.749 1.00 95.99 N \\\\nATOM 1315 CA TYR A 167 -18.234 4.870 15.418 1.00 95.99 C \\\\nATOM 1316 C TYR A 167 -19.323 5.244 14.415 1.00 95.99 C \\\\nATOM 1317 CB TYR A 167 -17.535 3.543 15.095 1.00 95.99 C \\\\nATOM 1318 O TYR A 167 -20.494 4.939 14.606 1.00 95.99 O \\\\nATOM 1319 CG TYR A 167 -16.391 3.227 16.045 1.00 95.99 C \\\\nATOM 1320 CD1 TYR A 167 -15.102 3.728 15.781 1.00 95.99 C \\\\nATOM 1321 CD2 TYR A 167 -16.626 2.488 17.222 1.00 95.99 C \\\\nATOM 1322 CE1 TYR A 167 -14.053 3.494 16.690 1.00 95.99 C \\\\nATOM 1323 CE2 TYR A 167 -15.583 2.263 18.142 1.00 95.99 C \\\\nATOM 1324 OH TYR A 167 -13.262 2.544 18.736 1.00 95.99 O \\\\nATOM 1325 CZ TYR A 167 -14.291 2.772 17.876 1.00 95.99 C \\\\nATOM 1326 N GLN A 168 -18.962 5.909 13.336 1.00 93.44 N \\\\nATOM 1327 CA GLN A 168 -19.802 6.190 12.182 1.00 93.44 C \\\\nATOM 1328 C GLN A 168 -19.122 5.567 10.971 1.00 93.44 C \\\\nATOM 1329 CB GLN A 168 -19.992 7.702 12.024 1.00 93.44 C \\\\nATOM 1330 O GLN A 168 -17.891 5.559 10.897 1.00 93.44 O \\\\nATOM 1331 CG GLN A 168 -20.874 8.284 13.141 1.00 93.44 C \\\\nATOM 1332 CD GLN A 168 -20.992 9.804 13.068 1.00 93.44 C \\\\nATOM 1333 NE2 GLN A 168 -21.814 10.413 13.894 1.00 93.44 N \\\\nATOM 1334 OE1 GLN A 168 -20.336 10.479 12.298 1.00 93.44 O \\\\nATOM 1335 N ARG A 169 -19.905 5.005 10.051 1.00 91.38 N \\\\nATOM 1336 CA ARG A 169 -19.352 4.515 8.793 1.00 91.38 C \\\\nATOM 1337 C ARG A 169 -18.992 5.723 7.940 1.00 91.38 C \\\\nATOM 1338 CB ARG A 169 -20.329 3.558 8.104 1.00 91.38 C \\\\nATOM 1339 O ARG A 169 -19.748 6.688 7.908 1.00 91.38 O \\\\nATOM 1340 CG ARG A 169 -19.688 2.835 6.915 1.00 91.38 C \\\\nATOM 1341 CD ARG A 169 -20.634 1.759 6.375 1.00 91.38 C \\\\nATOM 1342 NE ARG A 169 -19.942 0.894 5.407 1.00 91.38 N \\\\nATOM 1343 NH1 ARG A 169 -21.627 -0.625 5.046 1.00 91.38 N \\\\nATOM 1344 NH2 ARG A 169 -19.646 -0.939 4.109 1.00 91.38 N \\\\nATOM 1345 CZ ARG A 169 -20.411 -0.206 4.856 1.00 91.38 C \\\\nATOM 1346 N VAL A 170 -17.837 5.680 7.296 1.00 88.40 N \\\\nATOM 1347 CA VAL A 170 -17.450 6.695 6.318 1.00 88.40 C \\\\nATOM 1348 C VAL A 170 -18.362 6.528 5.104 1.00 88.40 C \\\\nATOM 1349 CB VAL A 170 -15.959 6.576 5.956 1.00 88.40 C \\\\nATOM 1350 O VAL A 170 -18.325 5.495 4.438 1.00 88.40 O \\\\nATOM 1351 CG1 VAL A 170 -15.564 7.639 4.927 1.00 88.40 C \\\\nATOM 1352 CG2 VAL A 170 -15.075 6.775 7.199 1.00 88.40 C \\\\nATOM 1353 N GLU A 171 -19.219 7.514 4.864 1.00 82.22 N \\\\nATOM 1354 CA GLU A 171 -20.124 7.540 3.715 1.00 82.22 C \\\\nATOM 1355 C GLU A 171 -19.408 8.133 2.499 1.00 82.22 C \\\\nATOM 1356 CB GLU A 171 -21.407 8.317 4.059 1.00 82.22 C \\\\nATOM 1357 O GLU A 171 -18.624 9.076 2.625 1.00 82.22 O \\\\nATOM 1358 CG GLU A 171 -22.244 7.575 5.118 1.00 82.22 C \\\\nATOM 1359 CD GLU A 171 -23.545 8.288 5.520 1.00 82.22 C \\\\nATOM 1360 OE1 GLU A 171 -24.246 7.719 6.392 1.00 82.22 O \\\\nATOM 1361 OE2 GLU A 171 -23.828 9.381 4.983 1.00 82.22 O \\\\nATOM 1362 N THR A 172 -19.669 7.580 1.313 1.00 80.03 N \\\\nATOM 1363 CA THR A 172 -19.195 8.172 0.059 1.00 80.03 C \\\\nATOM 1364 C THR A 172 -20.025 9.421 -0.233 1.00 80.03 C \\\\nATOM 1365 CB THR A 172 -19.256 7.179 -1.107 1.00 80.03 C \\\\nATOM 1366 O THR A 172 -21.246 9.310 -0.362 1.00 80.03 O \\\\nATOM 1367 CG2 THR A 172 -18.685 7.755 -2.404 1.00 80.03 C \\\\nATOM 1368 OG1 THR A 172 -18.475 6.045 -0.796 1.00 80.03 O \\\\nATOM 1369 N PRO A 173 -19.405 10.609 -0.330 1.00 80.47 N \\\\nATOM 1370 CA PRO A 173 -20.132 11.834 -0.616 1.00 80.47 C \\\\nATOM 1371 C PRO A 173 -20.764 11.762 -2.009 1.00 80.47 C \\\\nATOM 1372 CB PRO A 173 -19.098 12.954 -0.499 1.00 80.47 C \\\\nATOM 1373 O PRO A 173 -20.144 11.285 -2.960 1.00 80.47 O \\\\nATOM 1374 CG PRO A 173 -17.772 12.263 -0.826 1.00 80.47 C \\\\nATOM 1375 CD PRO A 173 -17.973 10.853 -0.292 1.00 80.47 C \\\\nATOM 1376 N VAL A 174 -21.991 12.272 -2.140 1.00 82.51 N \\\\nATOM 1377 CA VAL A 174 -22.652 12.398 -3.445 1.00 82.51 C \\\\nATOM 1378 C VAL A 174 -21.908 13.453 -4.264 1.00 82.51 C \\\\nATOM 1379 CB VAL A 174 -24.147 12.744 -3.305 1.00 82.51 C \\\\nATOM 1380 O VAL A 174 -21.784 14.602 -3.839 1.00 82.51 O \\\\nATOM 1381 CG1 VAL A 174 -24.830 12.822 -4.677 1.00 82.51 C \\\\nATOM 1382 CG2 VAL A 174 -24.885 11.685 -2.474 1.00 82.51 C \\\\nATOM 1383 N LEU A 175 -21.392 13.056 -5.426 1.00 85.88 N \\\\nATOM 1384 CA LEU A 175 -20.677 13.953 -6.333 1.00 85.88 C \\\\nATOM 1385 C LEU A 175 -21.683 14.739 -7.196 1.00 85.88 C \\\\nATOM 1386 CB LEU A 175 -19.685 13.147 -7.190 1.00 85.88 C \\\\nATOM 1387 O LEU A 175 -22.635 14.137 -7.702 1.00 85.88 O \\\\nATOM 1388 CG LEU A 175 -18.604 12.400 -6.386 1.00 85.88 C \\\\nATOM 1389 CD1 LEU A 175 -17.801 11.463 -7.283 1.00 85.88 C \\\\nATOM 1390 CD2 LEU A 175 -17.627 13.363 -5.708 1.00 85.88 C \\\\nATOM 1391 N PRO A 176 -21.506 16.062 -7.378 1.00 86.02 N \\\\nATOM 1392 CA PRO A 176 -22.392 16.857 -8.224 1.00 86.02 C \\\\nATOM 1393 C PRO A 176 -22.263 16.431 -9.698 1.00 86.02 C \\\\nATOM 1394 CB PRO A 176 -21.967 18.312 -8.009 1.00 86.02 C \\\\nATOM 1395 O PRO A 176 -21.165 16.064 -10.123 1.00 86.02 O \\\\nATOM 1396 CG PRO A 176 -20.483 18.195 -7.657 1.00 86.02 C \\\\nATOM 1397 CD PRO A 176 -20.411 16.882 -6.878 1.00 86.02 C \\\\nATOM 1398 N PRO A 177 -23.344 16.482 -10.499 1.00 87.29 N \\\\nATOM 1399 CA PRO A 177 -23.257 16.213 -11.931 1.00 87.29 C \\\\nATOM 1400 C PRO A 177 -22.373 17.251 -12.631 1.00 87.29 C \\\\nATOM 1401 CB PRO A 177 -24.697 16.255 -12.451 1.00 87.29 C \\\\nATOM 1402 O PRO A 177 -22.425 18.440 -12.314 1.00 87.29 O \\\\nATOM 1403 CG PRO A 177 -25.403 17.184 -11.463 1.00 87.29 C \\\\nATOM 1404 CD PRO A 177 -24.688 16.909 -10.139 1.00 87.29 C \\\\nATOM 1405 N VAL A 178 -21.600 16.805 -13.619 1.00 87.57 N \\\\nATOM 1406 CA VAL A 178 -20.834 17.696 -14.500 1.00 87.57 C \\\\nATOM 1407 C VAL A 178 -21.767 18.192 -15.599 1.00 87.57 C \\\\nATOM 1408 CB VAL A 178 -19.596 16.981 -15.070 1.00 87.57 C \\\\nATOM 1409 O VAL A 178 -22.409 17.384 -16.266 1.00 87.57 O \\\\nATOM 1410 CG1 VAL A 178 -18.864 17.835 -16.108 1.00 87.57 C \\\\nATOM 1411 CG2 VAL A 178 -18.600 16.666 -13.950 1.00 87.57 C \\\\nATOM 1412 N LEU A 179 -21.873 19.509 -15.769 1.00 87.79 N \\\\nATOM 1413 CA LEU A 179 -22.702 20.119 -16.808 1.00 87.79 C \\\\nATOM 1414 C LEU A 179 -21.874 20.288 -18.081 1.00 87.79 C \\\\nATOM 1415 CB LEU A 179 -23.254 21.470 -16.317 1.00 87.79 C \\\\nATOM 1416 O LEU A 179 -20.872 20.998 -18.060 1.00 87.79 O \\\\nATOM 1417 CG LEU A 179 -24.097 21.415 -15.032 1.00 87.79 C \\\\nATOM 1418 CD1 LEU A 179 -24.620 22.811 -14.697 1.00 87.79 C \\\\nATOM 1419 CD2 LEU A 179 -25.295 20.471 -15.156 1.00 87.79 C \\\\nATOM 1420 N VAL A 180 -22.289 19.647 -19.172 1.00 84.28 N \\\\nATOM 1421 CA VAL A 180 -21.601 19.720 -20.466 1.00 84.28 C \\\\nATOM 1422 C VAL A 180 -22.396 20.613 -21.422 1.00 84.28 C \\\\nATOM 1423 CB VAL A 180 -21.359 18.323 -21.065 1.00 84.28 C \\\\nATOM 1424 O VAL A 180 -23.571 20.321 -21.665 1.00 84.28 O \\\\nATOM 1425 CG1 VAL A 180 -20.531 18.447 -22.348 1.00 84.28 C \\\\nATOM 1426 CG2 VAL A 180 -20.586 17.436 -20.078 1.00 84.28 C \\\\nATOM 1427 N PRO A 181 -21.807 21.693 -21.967 1.00 78.12 N \\\\nATOM 1428 CA PRO A 181 -22.442 22.482 -23.017 1.00 78.12 C \\\\nATOM 1429 C PRO A 181 -22.627 21.643 -24.281 1.00 78.12 C \\\\nATOM 1430 CB PRO A 181 -21.519 23.687 -23.260 1.00 78.12 C \\\\nATOM 1431 O PRO A 181 -21.658 21.102 -24.813 1.00 78.12 O \\\\nATOM 1432 CG PRO A 181 -20.643 23.753 -22.010 1.00 78.12 C \\\\nATOM 1433 CD PRO A 181 -20.538 22.293 -21.584 1.00 78.12 C \\\\nATOM 1434 N ARG A 182 -23.855 21.550 -24.801 1.00 67.49 N \\\\nATOM 1435 CA ARG A 182 -24.062 21.007 -26.146 1.00 67.49 C \\\\nATOM 1436 C ARG A 182 -23.515 21.998 -27.170 1.00 67.49 C \\\\nATOM 1437 CB ARG A 182 -25.542 20.692 -26.386 1.00 67.49 C \\\\nATOM 1438 O ARG A 182 -23.953 23.146 -27.230 1.00 67.49 O \\\\nATOM 1439 CG ARG A 182 -25.978 19.452 -25.594 1.00 67.49 C \\\\nATOM 1440 CD ARG A 182 -27.438 19.144 -25.917 1.00 67.49 C \\\\nATOM 1441 NE ARG A 182 -27.885 17.885 -25.302 1.00 67.49 N \\\\nATOM 1442 NH1 ARG A 182 -30.126 18.198 -25.717 1.00 67.49 N \\\\nATOM 1443 NH2 ARG A 182 -29.440 16.332 -24.732 1.00 67.49 N \\\\nATOM 1444 CZ ARG A 182 -29.139 17.478 -25.265 1.00 67.49 C \\\\nATOM 1445 N HIS A 183 -22.548 21.562 -27.974 1.00 57.15 N \\\\nATOM 1446 CA HIS A 183 -22.051 22.350 -29.097 1.00 57.15 C \\\\nATOM 1447 C HIS A 183 -23.143 22.490 -30.162 1.00 57.15 C \\\\nATOM 1448 CB HIS A 183 -20.776 21.713 -29.680 1.00 57.15 C \\\\nATOM 1449 O HIS A 183 -23.293 21.614 -31.012 1.00 57.15 O \\\\nATOM 1450 CG HIS A 183 -19.515 22.141 -28.978 1.00 57.15 C \\\\nATOM 1451 CD2 HIS A 183 -18.673 21.359 -28.233 1.00 57.15 C \\\\nATOM 1452 ND1 HIS A 183 -18.973 23.407 -29.012 1.00 57.15 N \\\\nATOM 1453 CE1 HIS A 183 -17.836 23.388 -28.298 1.00 57.15 C \\\\nATOM 1454 NE2 HIS A 183 -17.608 22.162 -27.810 1.00 57.15 N \\\\nATOM 1455 N THR A 184 -23.876 23.605 -30.134 1.00 46.80 N \\\\nATOM 1456 CA THR A 184 -24.677 24.042 -31.286 1.00 46.80 C \\\\nATOM 1457 C THR A 184 -23.954 25.106 -32.118 1.00 46.80 C \\\\nATOM 1458 CB THR A 184 -26.113 24.462 -30.917 1.00 46.80 C \\\\nATOM 1459 O THR A 184 -24.179 25.140 -33.319 1.00 46.80 O \\\\nATOM 1460 CG2 THR A 184 -27.094 24.160 -32.053 1.00 46.80 C \\\\nATOM 1461 OG1 THR A 184 -26.596 23.744 -29.802 1.00 46.80 O \\\\nATOM 1462 N GLU A 185 -23.029 25.915 -31.574 1.00 42.59 N \\\\nATOM 1463 CA GLU A 185 -22.300 26.939 -32.355 1.00 42.59 C \\\\nATOM 1464 C GLU A 185 -20.865 27.188 -31.829 1.00 42.59 C \\\\nATOM 1465 CB GLU A 185 -23.118 28.248 -32.437 1.00 42.59 C \\\\nATOM 1466 O GLU A 185 -20.599 27.141 -30.628 1.00 42.59 O \\\\nATOM 1467 CG GLU A 185 -24.438 28.065 -33.220 1.00 42.59 C \\\\nATOM 1468 CD GLU A 185 -25.260 29.335 -33.440 1.00 42.59 C \\\\nATOM 1469 OE1 GLU A 185 -26.206 29.262 -34.258 1.00 42.59 O \\\\nATOM 1470 OE2 GLU A 185 -24.976 30.351 -32.769 1.00 42.59 O \\\\nATOM 1471 N ILE A 186 -19.920 27.403 -32.751 1.00 43.70 N \\\\nATOM 1472 CA ILE A 186 -18.473 27.564 -32.524 1.00 43.70 C \\\\nATOM 1473 C ILE A 186 -18.190 28.959 -31.940 1.00 43.70 C \\\\nATOM 1474 CB ILE A 186 -17.731 27.351 -33.876 1.00 43.70 C \\\\nATOM 1475 O ILE A 186 -18.321 29.960 -32.645 1.00 43.70 O \\\\nATOM 1476 CG1 ILE A 186 -17.917 25.903 -34.397 1.00 43.70 C \\\\nATOM 1477 CG2 ILE A 186 -16.227 27.681 -33.786 1.00 43.70 C \\\\nATOM 1478 CD1 ILE A 186 -17.621 25.743 -35.895 1.00 43.70 C \\\\nATOM 1479 N LEU A 187 -17.743 29.045 -30.682 1.00 41.65 N \\\\nATOM 1480 CA LEU A 187 -17.145 30.279 -30.164 1.00 41.65 C \\\\nATOM 1481 C LEU A 187 -15.734 30.433 -30.738 1.00 41.65 C \\\\nATOM 1482 CB LEU A 187 -17.170 30.334 -28.626 1.00 41.65 C \\\\nATOM 1483 O LEU A 187 -14.805 29.707 -30.389 1.00 41.65 O \\\\nATOM 1484 CG LEU A 187 -18.565 30.585 -28.022 1.00 41.65 C \\\\nATOM 1485 CD1 LEU A 187 -18.455 30.600 -26.497 1.00 41.65 C \\\\nATOM 1486 CD2 LEU A 187 -19.178 31.921 -28.456 1.00 41.65 C \\\\nATOM 1487 N THR A 188 -15.608 31.387 -31.655 1.00 39.88 N \\\\nATOM 1488 CA THR A 188 -14.369 31.743 -32.347 1.00 39.88 C \\\\nATOM 1489 C THR A 188 -13.667 32.847 -31.557 1.00 39.88 C \\\\nATOM 1490 CB THR A 188 -14.652 32.176 -33.805 1.00 39.88 C \\\\nATOM 1491 O THR A 188 -13.729 33.993 -31.963 1.00 39.88 O \\\\nATOM 1492 CG2 THR A 188 -13.409 32.051 -34.686 1.00 39.88 C \\\\nATOM 1493 OG1 THR A 188 -15.632 31.356 -34.407 1.00 39.88 O \\\\nATOM 1494 N GLU A 189 -13.096 32.520 -30.393 1.00 39.17 N \\\\nATOM 1495 CA GLU A 189 -12.008 33.261 -29.717 1.00 39.17 C \\\\nATOM 1496 C GLU A 189 -11.721 32.594 -28.357 1.00 39.17 C \\\\nATOM 1497 CB GLU A 189 -12.299 34.776 -29.537 1.00 39.17 C \\\\nATOM 1498 O GLU A 189 -12.476 32.743 -27.398 1.00 39.17 O \\\\nATOM 1499 CG GLU A 189 -11.503 35.615 -30.564 1.00 39.17 C \\\\nATOM 1500 CD GLU A 189 -11.864 37.112 -30.592 1.00 39.17 C \\\\nATOM 1501 OE1 GLU A 189 -11.347 37.804 -31.501 1.00 39.17 O \\\\nATOM 1502 OE2 GLU A 189 -12.600 37.578 -29.692 1.00 39.17 O \\\\nATOM 1503 N LEU A 190 -10.632 31.819 -28.274 1.00 46.02 N \\\\nATOM 1504 CA LEU A 190 -10.084 31.291 -27.019 1.00 46.02 C \\\\nATOM 1505 C LEU A 190 -8.787 32.052 -26.685 1.00 46.02 C \\\\nATOM 1506 CB LEU A 190 -9.839 29.770 -27.126 1.00 46.02 C \\\\nATOM 1507 O LEU A 190 -7.996 32.310 -27.598 1.00 46.02 O \\\\nATOM 1508 CG LEU A 190 -11.069 28.909 -26.773 1.00 46.02 C \\\\nATOM 1509 CD1 LEU A 190 -10.925 27.510 -27.372 1.00 46.02 C \\\\nATOM 1510 CD2 LEU A 190 -11.236 28.751 -25.258 1.00 46.02 C \\\\nATOM 1511 N PRO A 191 -8.544 32.405 -25.407 1.00 44.40 N \\\\nATOM 1512 CA PRO A 191 -7.281 32.997 -24.973 1.00 44.40 C \\\\nATOM 1513 C PRO A 191 -6.117 32.019 -25.213 1.00 44.40 C \\\\nATOM 1514 CB PRO A 191 -7.478 33.357 -23.496 1.00 44.40 C \\\\nATOM 1515 O PRO A 191 -6.349 30.810 -25.301 1.00 44.40 O \\\\nATOM 1516 CG PRO A 191 -8.582 32.417 -23.018 1.00 44.40 C \\\\nATOM 1517 CD PRO A 191 -9.399 32.116 -24.270 1.00 44.40 C \\\\nATOM 1518 N PRO A 192 -4.872 32.515 -25.343 1.00 44.87 N \\\\nATOM 1519 CA PRO A 192 -3.722 31.678 -25.668 1.00 44.87 C \\\\nATOM 1520 C PRO A 192 -3.588 30.547 -24.642 1.00 44.87 C \\\\nATOM 1521 CB PRO A 192 -2.510 32.619 -25.694 1.00 44.87 C \\\\nATOM 1522 O PRO A 192 -3.456 30.796 -23.446 1.00 44.87 O \\\\nATOM 1523 CG PRO A 192 -2.947 33.804 -24.832 1.00 44.87 C \\\\nATOM 1524 CD PRO A 192 -4.452 33.878 -25.071 1.00 44.87 C \\\\nATOM 1525 N LEU A 193 -3.669 29.307 -25.127 1.00 47.96 N \\\\nATOM 1526 CA LEU A 193 -3.348 28.114 -24.354 1.00 47.96 C \\\\nATOM 1527 C LEU A 193 -1.859 28.168 -24.002 1.00 47.96 C \\\\nATOM 1528 CB LEU A 193 -3.669 26.855 -25.189 1.00 47.96 C \\\\nATOM 1529 O LEU A 193 -1.025 28.289 -24.900 1.00 47.96 O \\\\nATOM 1530 CG LEU A 193 -5.169 26.516 -25.287 1.00 47.96 C \\\\nATOM 1531 CD1 LEU A 193 -5.420 25.532 -26.432 1.00 47.96 C \\\\nATOM 1532 CD2 LEU A 193 -5.678 25.874 -23.994 1.00 47.96 C \\\\nATOM 1533 N ASP A 194 -1.534 28.058 -22.714 1.00 43.48 N \\\\nATOM 1534 CA ASP A 194 -0.163 27.779 -22.297 1.00 43.48 C \\\\nATOM 1535 C ASP A 194 0.288 26.455 -22.931 1.00 43.48 C \\\\nATOM 1536 CB ASP A 194 -0.029 27.747 -20.764 1.00 43.48 C \\\\nATOM 1537 O ASP A 194 -0.447 25.463 -22.966 1.00 43.48 O \\\\nATOM 1538 CG ASP A 194 0.055 29.139 -20.120 1.00 43.48 C \\\\nATOM 1539 OD1 ASP A 194 0.655 30.045 -20.741 1.00 43.48 O \\\\nATOM 1540 OD2 ASP A 194 -0.427 29.269 -18.971 1.00 43.48 O \\\\nATOM 1541 N ASP A 195 1.502 26.463 -23.471 1.00 40.98 N \\\\nATOM 1542 CA ASP A 195 2.109 25.353 -24.193 1.00 40.98 C \\\\nATOM 1543 C ASP A 195 2.381 24.181 -23.226 1.00 40.98 C \\\\nATOM 1544 CB ASP A 195 3.357 25.896 -24.920 1.00 40.98 C \\\\nATOM 1545 O ASP A 195 3.425 24.073 -22.582 1.00 40.98 O \\\\nATOM 1546 CG ASP A 195 3.821 25.038 -26.099 1.00 40.98 C \\\\nATOM 1547 OD1 ASP A 195 3.338 23.887 -26.222 1.00 40.98 O \\\\nATOM 1548 OD2 ASP A 195 4.683 25.520 -26.864 1.00 40.98 O \\\\nATOM 1549 N TYR A 196 1.401 23.287 -23.074 1.00 45.99 N \\\\nATOM 1550 CA TYR A 196 1.498 22.073 -22.256 1.00 45.99 C \\\\nATOM 1551 C TYR A 196 2.280 20.949 -22.954 1.00 45.99 C \\\\nATOM 1552 CB TYR A 196 0.104 21.626 -21.782 1.00 45.99 C \\\\nATOM 1553 O TYR A 196 2.133 19.776 -22.601 1.00 45.99 O \\\\nATOM 1554 CG TYR A 196 -0.449 22.425 -20.621 1.00 45.99 C \\\\nATOM 1555 CD1 TYR A 196 0.004 22.188 -19.305 1.00 45.99 C \\\\nATOM 1556 CD2 TYR A 196 -1.435 23.397 -20.858 1.00 45.99 C \\\\nATOM 1557 CE1 TYR A 196 -0.532 22.927 -18.231 1.00 45.99 C \\\\nATOM 1558 CE2 TYR A 196 -1.974 24.134 -19.790 1.00 45.99 C \\\\nATOM 1559 OH TYR A 196 -2.055 24.617 -17.450 1.00 45.99 O \\\\nATOM 1560 CZ TYR A 196 -1.526 23.902 -18.477 1.00 45.99 C \\\\nATOM 1561 N THR A 197 3.168 21.259 -23.899 1.00 44.07 N \\\\nATOM 1562 CA THR A 197 4.138 20.294 -24.449 1.00 44.07 C \\\\nATOM 1563 C THR A 197 5.068 19.704 -23.373 1.00 44.07 C \\\\nATOM 1564 CB THR A 197 4.937 20.916 -25.605 1.00 44.07 C \\\\nATOM 1565 O THR A 197 5.636 18.633 -23.572 1.00 44.07 O \\\\nATOM 1566 CG2 THR A 197 4.119 20.933 -26.895 1.00 44.07 C \\\\nATOM 1567 OG1 THR A 197 5.316 22.233 -25.300 1.00 44.07 O \\\\nATOM 1568 N HIS A 198 5.111 20.292 -22.171 1.00 42.09 N \\\\nATOM 1569 CA HIS A 198 5.744 19.726 -20.969 1.00 42.09 C \\\\nATOM 1570 C HIS A 198 4.830 18.831 -20.098 1.00 42.09 C \\\\nATOM 1571 CB HIS A 198 6.354 20.877 -20.161 1.00 42.09 C \\\\nATOM 1572 O HIS A 198 5.241 18.362 -19.037 1.00 42.09 O \\\\nATOM 1573 CG HIS A 198 7.428 21.607 -20.924 1.00 42.09 C \\\\nATOM 1574 CD2 HIS A 198 7.425 22.924 -21.302 1.00 42.09 C \\\\nATOM 1575 ND1 HIS A 198 8.589 21.047 -21.409 1.00 42.09 N \\\\nATOM 1576 CE1 HIS A 198 9.273 22.005 -22.054 1.00 42.09 C \\\\nATOM 1577 NE2 HIS A 198 8.615 23.170 -21.994 1.00 42.09 N \\\\nATOM 1578 N SER A 199 3.585 18.569 -20.513 1.00 43.75 N \\\\nATOM 1579 CA SER A 199 2.611 17.784 -19.731 1.00 43.75 C \\\\nATOM 1580 C SER A 199 2.780 16.269 -19.848 1.00 43.75 C \\\\nATOM 1581 CB SER A 199 1.176 18.147 -20.110 1.00 43.75 C \\\\nATOM 1582 O SER A 199 2.189 15.538 -19.049 1.00 43.75 O \\\\nATOM 1583 OG SER A 199 0.904 17.723 -21.433 1.00 43.75 O \\\\nATOM 1584 N ILE A 200 3.559 15.781 -20.821 1.00 42.94 N \\\\nATOM 1585 CA ILE A 200 4.083 14.414 -20.812 1.00 42.94 C \\\\nATOM 1586 C ILE A 200 5.367 14.491 -20.005 1.00 42.94 C \\\\nATOM 1587 CB ILE A 200 4.378 13.862 -22.226 1.00 42.94 C \\\\nATOM 1588 O ILE A 200 6.360 15.025 -20.501 1.00 42.94 O \\\\nATOM 1589 CG1 ILE A 200 3.113 13.892 -23.105 1.00 42.94 C \\\\nATOM 1590 CG2 ILE A 200 4.921 12.419 -22.113 1.00 42.94 C \\\\nATOM 1591 CD1 ILE A 200 3.385 13.574 -24.580 1.00 42.94 C \\\\nATOM 1592 N PRO A 201 5.411 13.973 -18.773 1.00 48.89 N \\\\nATOM 1593 CA PRO A 201 6.698 13.882 -18.145 1.00 48.89 C \\\\nATOM 1594 C PRO A 201 7.513 12.838 -18.892 1.00 48.89 C \\\\nATOM 1595 CB PRO A 201 6.435 13.536 -16.703 1.00 48.89 C \\\\nATOM 1596 O PRO A 201 7.066 11.701 -19.058 1.00 48.89 O \\\\nATOM 1597 CG PRO A 201 4.922 13.301 -16.558 1.00 48.89 C \\\\nATOM 1598 CD PRO A 201 4.381 13.323 -17.983 1.00 48.89 C \\\\nATOM 1599 N GLU A 202 8.725 13.207 -19.300 1.00 54.78 N \\\\nATOM 1600 CA GLU A 202 9.679 12.321 -19.981 1.00 54.78 C \\\\nATOM 1601 C GLU A 202 9.876 10.989 -19.236 1.00 54.78 C \\\\nATOM 1602 CB GLU A 202 11.032 13.036 -20.092 1.00 54.78 C \\\\nATOM 1603 O GLU A 202 10.212 9.968 -19.833 1.00 54.78 O \\\\nATOM 1604 CG GLU A 202 11.007 14.228 -21.061 1.00 54.78 C \\\\nATOM 1605 CD GLU A 202 12.381 14.908 -21.171 1.00 54.78 C \\\\nATOM 1606 OE1 GLU A 202 12.648 15.502 -22.237 1.00 54.78 O \\\\nATOM 1607 OE2 GLU A 202 13.154 14.818 -20.188 1.00 54.78 O \\\\nATOM 1608 N ASN A 203 9.570 10.956 -17.934 1.00 64.59 N \\\\nATOM 1609 CA ASN A 203 9.573 9.748 -17.121 1.00 64.59 C \\\\nATOM 1610 C ASN A 203 8.459 8.712 -17.415 1.00 64.59 C \\\\nATOM 1611 CB ASN A 203 9.696 10.114 -15.636 1.00 64.59 C \\\\nATOM 1612 O ASN A 203 8.453 7.652 -16.776 1.00 64.59 O \\\\nATOM 1613 CG ASN A 203 8.514 10.710 -14.914 1.00 64.59 C \\\\nATOM 1614 ND2 ASN A 203 8.751 11.229 -13.733 1.00 64.59 N \\\\nATOM 1615 OD1 ASN A 203 7.370 10.626 -15.308 1.00 64.59 O \\\\nATOM 1616 N THR A 204 7.555 8.980 -18.366 1.00 56.41 N \\\\nATOM 1617 CA THR A 204 6.367 8.156 -18.675 1.00 56.41 C \\\\nATOM 1618 C THR A 204 6.367 7.475 -20.049 1.00 56.41 C \\\\nATOM 1619 CB THR A 204 5.059 8.951 -18.512 1.00 56.41 C \\\\nATOM 1620 O THR A 204 5.433 6.726 -20.332 1.00 56.41 O \\\\nATOM 1621 CG2 THR A 204 4.880 9.530 -17.113 1.00 56.41 C \\\\nATOM 1622 OG1 THR A 204 4.971 10.026 -19.414 1.00 56.41 O \\\\nATOM 1623 N ASN A 205 7.384 7.676 -20.897 1.00 49.30 N \\\\nATOM 1624 CA ASN A 205 7.339 7.163 -22.271 1.00 49.30 C \\\\nATOM 1625 C ASN A 205 7.411 5.624 -22.351 1.00 49.30 C \\\\nATOM 1626 CB ASN A 205 8.401 7.859 -23.157 1.00 49.30 C \\\\nATOM 1627 O ASN A 205 8.383 4.995 -21.919 1.00 49.30 O \\\\nATOM 1628 CG ASN A 205 7.823 8.911 -24.097 1.00 49.30 C \\\\nATOM 1629 ND2 ASN A 205 8.634 9.491 -24.948 1.00 49.30 N \\\\nATOM 1630 OD1 ASN A 205 6.647 9.226 -24.088 1.00 49.30 O \\\\nATOM 1631 N PHE A 206 6.385 5.039 -22.974 1.00 41.13 N \\\\nATOM 1632 CA PHE A 206 6.423 3.713 -23.590 1.00 41.13 C \\\\nATOM 1633 C PHE A 206 6.857 3.858 -25.057 1.00 41.13 C \\\\nATOM 1634 CB PHE A 206 5.035 3.059 -23.535 1.00 41.13 C \\\\nATOM 1635 O PHE A 206 6.550 4.880 -25.673 1.00 41.13 O \\\\nATOM 1636 CG PHE A 206 4.514 2.747 -22.147 1.00 41.13 C \\\\nATOM 1637 CD1 PHE A 206 4.761 1.489 -21.561 1.00 41.13 C \\\\nATOM 1638 CD2 PHE A 206 3.716 3.689 -21.474 1.00 41.13 C \\\\nATOM 1639 CE1 PHE A 206 4.166 1.158 -20.330 1.00 41.13 C \\\\nATOM 1640 CE2 PHE A 206 3.120 3.357 -20.247 1.00 41.13 C \\\\nATOM 1641 CZ PHE A 206 3.318 2.084 -19.694 1.00 41.13 C \\\\nATOM 1642 N PRO A 207 7.522 2.860 -25.663 1.00 35.10 N \\\\nATOM 1643 CA PRO A 207 7.728 2.862 -27.104 1.00 35.10 C \\\\nATOM 1644 C PRO A 207 6.383 2.618 -27.804 1.00 35.10 C \\\\nATOM 1645 CB PRO A 207 8.771 1.770 -27.363 1.00 35.10 C \\\\nATOM 1646 O PRO A 207 5.911 1.486 -27.892 1.00 35.10 O \\\\nATOM 1647 CG PRO A 207 8.559 0.782 -26.214 1.00 35.10 C \\\\nATOM 1648 CD PRO A 207 8.049 1.647 -25.059 1.00 35.10 C \\\\nATOM 1649 N ALA A 208 5.752 3.680 -28.303 1.00 33.84 N \\\\nATOM 1650 CA ALA A 208 4.773 3.562 -29.375 1.00 33.84 C \\\\nATOM 1651 C ALA A 208 5.554 3.220 -30.654 1.00 33.84 C \\\\nATOM 1652 CB ALA A 208 3.977 4.870 -29.479 1.00 33.84 C \\\\nATOM 1653 O ALA A 208 6.194 4.086 -31.242 1.00 33.84 O \\\\nATOM 1654 N GLY A 209 5.598 1.936 -31.016 1.00 29.29 N \\\\nATOM 1655 CA GLY A 209 6.338 1.481 -32.193 1.00 29.29 C \\\\nATOM 1656 C GLY A 209 6.670 -0.006 -32.166 1.00 29.29 C \\\\nATOM 1657 O GLY A 209 7.836 -0.376 -32.081 1.00 29.29 O \\\\nATOM 1658 N ILE A 210 5.653 -0.865 -32.237 1.00 34.22 N \\\\nATOM 1659 CA ILE A 210 5.816 -2.192 -32.838 1.00 34.22 C \\\\nATOM 1660 C ILE A 210 4.875 -2.199 -34.036 1.00 34.22 C \\\\nATOM 1661 CB ILE A 210 5.576 -3.353 -31.843 1.00 34.22 C \\\\nATOM 1662 O ILE A 210 3.655 -2.203 -33.873 1.00 34.22 O \\\\nATOM 1663 CG1 ILE A 210 6.570 -3.264 -30.660 1.00 34.22 C \\\\nATOM 1664 CG2 ILE A 210 5.729 -4.704 -32.570 1.00 34.22 C \\\\nATOM 1665 CD1 ILE A 210 6.384 -4.344 -29.585 1.00 34.22 C \\\\nATOM 1666 N GLU A 211 5.458 -2.118 -35.229 1.00 29.47 N \\\\nATOM 1667 CA GLU A 211 4.771 -2.379 -36.491 1.00 29.47 C \\\\nATOM 1668 C GLU A 211 4.011 -3.714 -36.392 1.00 29.47 C \\\\nATOM 1669 CB GLU A 211 5.802 -2.499 -37.624 1.00 29.47 C \\\\nATOM 1670 O GLU A 211 4.579 -4.702 -35.910 1.00 29.47 O \\\\nATOM 1671 CG GLU A 211 6.550 -1.198 -37.940 1.00 29.47 C \\\\nATOM 1672 CD GLU A 211 7.571 -1.409 -39.071 1.00 29.47 C \\\\nATOM 1673 OE1 GLU A 211 7.591 -0.576 -40.002 1.00 29.47 O \\\\nATOM 1674 OE2 GLU A 211 8.328 -2.405 -38.988 1.00 29.47 O \\\\nATOM 1675 N PRO A 212 2.747 -3.800 -36.837 1.00 32.98 N \\\\nATOM 1676 CA PRO A 212 2.040 -5.065 -36.836 1.00 32.98 C \\\\nATOM 1677 C PRO A 212 2.586 -5.915 -37.986 1.00 32.98 C \\\\nATOM 1678 CB PRO A 212 0.560 -4.696 -36.957 1.00 32.98 C \\\\nATOM 1679 O PRO A 212 2.143 -5.812 -39.129 1.00 32.98 O \\\\nATOM 1680 CG PRO A 212 0.579 -3.395 -37.760 1.00 32.98 C \\\\nATOM 1681 CD PRO A 212 1.919 -2.746 -37.402 1.00 32.98 C \\\\nATOM 1682 N GLN A 213 3.550 -6.788 -37.688 1.00 33.15 N \\\\nATOM 1683 CA GLN A 213 3.832 -7.926 -38.553 1.00 33.15 C \\\\nATOM 1684 C GLN A 213 2.620 -8.861 -38.511 1.00 33.15 C \\\\nATOM 1685 CB GLN A 213 5.141 -8.631 -38.170 1.00 33.15 C \\\\nATOM 1686 O GLN A 213 2.426 -9.630 -37.572 1.00 33.15 O \\\\nATOM 1687 CG GLN A 213 6.360 -7.846 -38.680 1.00 33.15 C \\\\nATOM 1688 CD GLN A 213 7.684 -8.575 -38.463 1.00 33.15 C \\\\nATOM 1689 NE2 GLN A 213 8.735 -8.163 -39.138 1.00 33.15 N \\\\nATOM 1690 OE1 GLN A 213 7.815 -9.515 -37.695 1.00 33.15 O \\\\nATOM 1691 N SER A 214 1.776 -8.698 -39.530 1.00 28.82 N \\\\nATOM 1692 CA SER A 214 0.949 -9.711 -40.183 1.00 28.82 C \\\\nATOM 1693 C SER A 214 0.850 -11.054 -39.449 1.00 28.82 C \\\\nATOM 1694 CB SER A 214 1.532 -9.943 -41.589 1.00 28.82 C \\\\nATOM 1695 O SER A 214 1.736 -11.894 -39.588 1.00 28.82 O \\\\nATOM 1696 OG SER A 214 2.881 -10.376 -41.529 1.00 28.82 O \\\\nATOM 1697 N ASN A 215 -0.261 -11.301 -38.753 1.00 34.40 N \\\\nATOM 1698 CA ASN A 215 -0.771 -12.656 -38.568 1.00 34.40 C \\\\nATOM 1699 C ASN A 215 -2.291 -12.627 -38.360 1.00 34.40 C \\\\nATOM 1700 CB ASN A 215 -0.009 -13.410 -37.457 1.00 34.40 C \\\\nATOM 1701 O ASN A 215 -2.806 -12.058 -37.404 1.00 34.40 O \\\\nATOM 1702 CG ASN A 215 1.130 -14.267 -38.005 1.00 34.40 C \\\\nATOM 1703 ND2 ASN A 215 2.151 -14.511 -37.219 1.00 34.40 N \\\\nATOM 1704 OD1 ASN A 215 1.103 -14.773 -39.116 1.00 34.40 O \\\\nATOM 1705 N TYR A 216 -2.961 -13.225 -39.344 1.00 29.75 N \\\\nATOM 1706 CA TYR A 216 -4.365 -13.598 -39.470 1.00 29.75 C \\\\nATOM 1707 C TYR A 216 -5.182 -13.675 -38.168 1.00 29.75 C \\\\nATOM 1708 CB TYR A 216 -4.356 -14.989 -40.129 1.00 29.75 C \\\\nATOM 1709 O TYR A 216 -4.917 -14.511 -37.307 1.00 29.75 O \\\\nATOM 1710 CG TYR A 216 -4.028 -14.992 -41.611 1.00 29.75 C \\\\nATOM 1711 CD1 TYR A 216 -5.088 -15.091 -42.531 1.00 29.75 C \\\\nATOM 1712 CD2 TYR A 216 -2.697 -14.914 -42.080 1.00 29.75 C \\\\nATOM 1713 CE1 TYR A 216 -4.830 -15.108 -43.913 1.00 29.75 C \\\\nATOM 1714 CE2 TYR A 216 -2.437 -14.907 -43.466 1.00 29.75 C \\\\nATOM 1715 OH TYR A 216 -3.271 -15.017 -45.721 1.00 29.75 O \\\\nATOM 1716 CZ TYR A 216 -3.507 -15.008 -44.384 1.00 29.75 C \\\\nATOM 1717 N ILE A 217 -6.277 -12.912 -38.117 1.00 36.30 N \\\\nATOM 1718 CA ILE A 217 -7.477 -13.261 -37.345 1.00 36.30 C \\\\nATOM 1719 C ILE A 217 -8.657 -13.233 -38.337 1.00 36.30 C \\\\nATOM 1720 CB ILE A 217 -7.702 -12.323 -36.136 1.00 36.30 C \\\\nATOM 1721 O ILE A 217 -8.815 -12.221 -39.022 1.00 36.30 O \\\\nATOM 1722 CG1 ILE A 217 -6.452 -12.275 -35.225 1.00 36.30 C \\\\nATOM 1723 CG2 ILE A 217 -8.930 -12.810 -35.341 1.00 36.30 C \\\\nATOM 1724 CD1 ILE A 217 -6.571 -11.314 -34.035 1.00 36.30 C \\\\nATOM 1725 N PRO A 218 -9.443 -14.318 -38.481 1.00 32.96 N \\\\nATOM 1726 CA PRO A 218 -10.608 -14.346 -39.360 1.00 32.96 C \\\\nATOM 1727 C PRO A 218 -11.803 -13.572 -38.782 1.00 32.96 C \\\\nATOM 1728 CB PRO A 218 -10.946 -15.820 -39.605 1.00 32.96 C \\\\nATOM 1729 O PRO A 218 -11.941 -13.411 -37.572 1.00 32.96 O \\\\nATOM 1730 CG PRO A 218 -10.051 -16.621 -38.658 1.00 32.96 C \\\\nATOM 1731 CD PRO A 218 -9.295 -15.598 -37.813 1.00 32.96 C \\\\nATOM 1732 N GLU A 219 -12.654 -13.127 -39.705 1.00 30.87 N \\\\nATOM 1733 CA GLU A 219 -13.843 -12.283 -39.574 1.00 30.87 C \\\\nATOM 1734 C GLU A 219 -14.855 -12.670 -38.479 1.00 30.87 C \\\\nATOM 1735 CB GLU A 219 -14.609 -12.357 -40.910 1.00 30.87 C \\\\nATOM 1736 O GLU A 219 -15.227 -13.832 -38.327 1.00 30.87 O \\\\nATOM 1737 CG GLU A 219 -13.824 -11.896 -42.144 1.00 30.87 C \\\\nATOM 1738 CD GLU A 219 -14.698 -12.002 -43.401 1.00 30.87 C \\\\nATOM 1739 OE1 GLU A 219 -14.979 -10.943 -44.004 1.00 30.87 O \\\\nATOM 1740 OE2 GLU A 219 -15.076 -13.146 -43.743 1.00 30.87 O \\\\nATOM 1741 N THR A 220 -15.441 -11.649 -37.848 1.00 36.68 N \\\\nATOM 1742 CA THR A 220 -16.836 -11.658 -37.378 1.00 36.68 C \\\\nATOM 1743 C THR A 220 -17.442 -10.258 -37.576 1.00 36.68 C \\\\nATOM 1744 CB THR A 220 -17.000 -12.083 -35.902 1.00 36.68 C \\\\nATOM 1745 O THR A 220 -16.932 -9.297 -36.999 1.00 36.68 O \\\\nATOM 1746 CG2 THR A 220 -17.311 -13.572 -35.758 1.00 36.68 C \\\\nATOM 1747 OG1 THR A 220 -15.859 -11.832 -35.113 1.00 36.68 O \\\\nATOM 1748 N PRO A 221 -18.508 -10.089 -38.385 1.00 42.32 N \\\\nATOM 1749 CA PRO A 221 -19.201 -8.809 -38.514 1.00 42.32 C \\\\nATOM 1750 C PRO A 221 -20.236 -8.633 -37.382 1.00 42.32 C \\\\nATOM 1751 CB PRO A 221 -19.847 -8.851 -39.900 1.00 42.32 C \\\\nATOM 1752 O PRO A 221 -20.784 -9.632 -36.904 1.00 42.32 O \\\\nATOM 1753 CG PRO A 221 -20.189 -10.332 -40.078 1.00 42.32 C \\\\nATOM 1754 CD PRO A 221 -19.111 -11.072 -39.279 1.00 42.32 C \\\\nATOM 1755 N PRO A 222 -20.556 -7.399 -36.941 1.00 47.76 N \\\\nATOM 1756 CA PRO A 222 -21.640 -7.176 -35.990 1.00 47.76 C \\\\nATOM 1757 C PRO A 222 -23.023 -7.337 -36.662 1.00 47.76 C \\\\nATOM 1758 CB PRO A 222 -21.442 -5.774 -35.404 1.00 47.76 C \\\\nATOM 1759 O PRO A 222 -23.148 -7.094 -37.864 1.00 47.76 O \\\\nATOM 1760 CG PRO A 222 -20.184 -5.225 -36.082 1.00 47.76 C \\\\nATOM 1761 CD PRO A 222 -19.949 -6.129 -37.291 1.00 47.76 C \\\\nATOM 1762 N PRO A 223 -24.074 -7.726 -35.913 1.00 42.45 N \\\\nATOM 1763 CA PRO A 223 -25.353 -8.184 -36.465 1.00 42.45 C \\\\nATOM 1764 C PRO A 223 -26.228 -7.049 -37.015 1.00 42.45 C \\\\nATOM 1765 CB PRO A 223 -26.073 -8.914 -35.318 1.00 42.45 C \\\\nATOM 1766 O PRO A 223 -26.425 -6.032 -36.351 1.00 42.45 O \\\\nATOM 1767 CG PRO A 223 -25.013 -9.078 -34.231 1.00 42.45 C \\\\nATOM 1768 CD PRO A 223 -24.088 -7.897 -34.472 1.00 42.45 C \\\\nATOM 1769 N GLY A 224 -26.819 -7.264 -38.195 1.00 31.26 N \\\\nATOM 1770 CA GLY A 224 -27.895 -6.433 -38.735 1.00 31.26 C \\\\nATOM 1771 C GLY A 224 -29.232 -6.735 -38.057 1.00 31.26 C \\\\nATOM 1772 O GLY A 224 -29.611 -7.898 -37.926 1.00 31.26 O \\\\nATOM 1773 N TYR A 225 -29.949 -5.687 -37.649 1.00 42.75 N \\\\nATOM 1774 CA TYR A 225 -31.335 -5.777 -37.197 1.00 42.75 C \\\\nATOM 1775 C TYR A 225 -32.252 -5.158 -38.255 1.00 42.75 C \\\\nATOM 1776 CB TYR A 225 -31.515 -5.177 -35.793 1.00 42.75 C \\\\nATOM 1777 O TYR A 225 -32.238 -3.956 -38.508 1.00 42.75 O \\\\nATOM 1778 CG TYR A 225 -32.127 -6.155 -34.804 1.00 42.75 C \\\\nATOM 1779 CD1 TYR A 225 -33.524 -6.206 -34.627 1.00 42.75 C \\\\nATOM 1780 CD2 TYR A 225 -31.296 -7.033 -34.081 1.00 42.75 C \\\\nATOM 1781 CE1 TYR A 225 -34.087 -7.112 -33.708 1.00 42.75 C \\\\nATOM 1782 CE2 TYR A 225 -31.855 -7.941 -33.160 1.00 42.75 C \\\\nATOM 1783 OH TYR A 225 -33.792 -8.853 -32.080 1.00 42.75 O \\\\nATOM 1784 CZ TYR A 225 -33.252 -7.978 -32.969 1.00 42.75 C \\\\nATOM 1785 N ILE A 226 -32.999 -6.051 -38.888 1.00 36.55 N \\\\nATOM 1786 CA ILE A 226 -34.214 -5.839 -39.670 1.00 36.55 C \\\\nATOM 1787 C ILE A 226 -35.349 -5.370 -38.745 1.00 36.55 C \\\\nATOM 1788 CB ILE A 226 -34.596 -7.182 -40.357 1.00 36.55 C \\\\nATOM 1789 O ILE A 226 -35.517 -5.922 -37.659 1.00 36.55 O \\\\nATOM 1790 CG1 ILE A 226 -34.358 -8.412 -39.430 1.00 36.55 C \\\\nATOM 1791 CG2 ILE A 226 -33.797 -7.334 -41.664 1.00 36.55 C \\\\nATOM 1792 CD1 ILE A 226 -34.952 -9.729 -39.929 1.00 36.55 C \\\\nATOM 1793 N SER A 227 -36.143 -4.400 -39.199 1.00 47.93 N \\\\nATOM 1794 CA SER A 227 -37.483 -4.130 -38.667 1.00 47.93 C \\\\nATOM 1795 C SER A 227 -38.434 -3.907 -39.840 1.00 47.93 C \\\\nATOM 1796 CB SER A 227 -37.516 -2.924 -37.725 1.00 47.93 C \\\\nATOM 1797 O SER A 227 -38.234 -2.993 -40.640 1.00 47.93 O \\\\nATOM 1798 OG SER A 227 -36.754 -3.159 -36.553 1.00 47.93 O \\\\nATOM 1799 N GLU A 228 -39.414 -4.800 -39.935 1.00 46.11 N \\\\nATOM 1800 CA GLU A 228 -40.514 -4.858 -40.896 1.00 46.11 C \\\\nATOM 1801 C GLU A 228 -41.667 -3.894 -40.525 1.00 46.11 C \\\\nATOM 1802 CB GLU A 228 -41.021 -6.321 -40.936 1.00 46.11 C \\\\nATOM 1803 O GLU A 228 -41.901 -3.624 -39.349 1.00 46.11 O \\\\nATOM 1804 CG GLU A 228 -40.045 -7.298 -41.618 1.00 46.11 C \\\\nATOM 1805 CD GLU A 228 -40.428 -8.779 -41.415 1.00 46.11 C \\\\nATOM 1806 OE1 GLU A 228 -40.687 -9.476 -42.424 1.00 46.11 O \\\\nATOM 1807 OE2 GLU A 228 -40.337 -9.242 -40.252 1.00 46.11 O \\\\nATOM 1808 N ASP A 229 -42.363 -3.439 -41.575 1.00 43.27 N \\\\nATOM 1809 CA ASP A 229 -43.800 -3.134 -41.730 1.00 43.27 C \\\\nATOM 1810 C ASP A 229 -44.535 -2.042 -40.918 1.00 43.27 C \\\\nATOM 1811 CB ASP A 229 -44.587 -4.454 -41.742 1.00 43.27 C \\\\nATOM 1812 O ASP A 229 -44.500 -1.981 -39.691 1.00 43.27 O \\\\nATOM 1813 CG ASP A 229 -44.099 -5.419 -42.832 1.00 43.27 C \\\\nATOM 1814 OD1 ASP A 229 -43.547 -4.923 -43.845 1.00 43.27 O \\\\nATOM 1815 OD2 ASP A 229 -44.293 -6.638 -42.646 1.00 43.27 O \\\\nATOM 1816 N GLY A 230 -45.339 -1.235 -41.644 1.00 41.83 N \\\\nATOM 1817 CA GLY A 230 -46.419 -0.420 -41.058 1.00 41.83 C \\\\nATOM 1818 C GLY A 230 -46.959 0.792 -41.851 1.00 41.83 C \\\\nATOM 1819 O GLY A 230 -46.917 1.899 -41.337 1.00 41.83 O \\\\nATOM 1820 N GLU A 231 -47.436 0.576 -43.083 1.00 42.15 N \\\\nATOM 1821 CA GLU A 231 -48.653 1.121 -43.747 1.00 42.15 C \\\\nATOM 1822 C GLU A 231 -49.152 2.603 -43.629 1.00 42.15 C \\\\nATOM 1823 CB GLU A 231 -49.811 0.155 -43.417 1.00 42.15 C \\\\nATOM 1824 O GLU A 231 -49.428 3.117 -42.550 1.00 42.15 O \\\\nATOM 1825 CG GLU A 231 -49.540 -1.282 -43.904 1.00 42.15 C \\\\nATOM 1826 CD GLU A 231 -50.767 -2.196 -43.772 1.00 42.15 C \\\\nATOM 1827 OE1 GLU A 231 -51.040 -2.932 -44.747 1.00 42.15 O \\\\nATOM 1828 OE2 GLU A 231 -51.429 -2.146 -42.712 1.00 42.15 O \\\\nATOM 1829 N THR A 232 -49.529 3.161 -44.808 1.00 42.91 N \\\\nATOM 1830 CA THR A 232 -50.599 4.171 -45.128 1.00 42.91 C \\\\nATOM 1831 C THR A 232 -50.304 5.675 -44.888 1.00 42.91 C \\\\nATOM 1832 CB THR A 232 -51.949 3.746 -44.514 1.00 42.91 C \\\\nATOM 1833 O THR A 232 -49.792 6.040 -43.845 1.00 42.91 O \\\\nATOM 1834 CG2 THR A 232 -52.463 2.399 -45.036 1.00 42.91 C \\\\nATOM 1835 OG1 THR A 232 -51.949 3.754 -43.110 1.00 42.91 O \\\\nATOM 1836 N SER A 233 -50.593 6.665 -45.754 1.00 42.08 N \\\\nATOM 1837 CA SER A 233 -51.392 6.803 -46.990 1.00 42.08 C \\\\nATOM 1838 C SER A 233 -50.855 7.944 -47.882 1.00 42.08 C \\\\nATOM 1839 CB SER A 233 -52.827 7.235 -46.655 1.00 42.08 C \\\\nATOM 1840 O SER A 233 -50.367 8.956 -47.382 1.00 42.08 O \\\\nATOM 1841 OG SER A 233 -53.568 6.191 -46.074 1.00 42.08 O \\\\nATOM 1842 N ASP A 234 -51.034 7.784 -49.195 1.00 37.27 N \\\\nATOM 1843 CA ASP A 234 -50.823 8.764 -50.269 1.00 37.27 C \\\\nATOM 1844 C ASP A 234 -51.973 9.792 -50.428 1.00 37.27 C \\\\nATOM 1845 CB ASP A 234 -50.708 7.975 -51.598 1.00 37.27 C \\\\nATOM 1846 O ASP A 234 -53.094 9.568 -49.971 1.00 37.27 O \\\\nATOM 1847 CG ASP A 234 -49.301 7.534 -51.967 1.00 37.27 C \\\\nATOM 1848 OD1 ASP A 234 -48.425 8.425 -51.963 1.00 37.27 O \\\\nATOM 1849 OD2 ASP A 234 -49.159 6.359 -52.367 1.00 37.27 O \\\\nATOM 1850 N GLN A 235 -51.692 10.795 -51.282 1.00 43.07 N \\\\nATOM 1851 CA GLN A 235 -52.589 11.706 -52.035 1.00 43.07 C \\\\nATOM 1852 C GLN A 235 -52.955 13.016 -51.294 1.00 43.07 C \\\\nATOM 1853 CB GLN A 235 -53.801 10.947 -52.638 1.00 43.07 C \\\\nATOM 1854 O GLN A 235 -53.390 12.989 -50.157 1.00 43.07 O \\\\nATOM 1855 CG GLN A 235 -53.418 9.621 -53.332 1.00 43.07 C \\\\nATOM 1856 CD GLN A 235 -54.524 8.941 -54.125 1.00 43.07 C \\\\nATOM 1857 NE2 GLN A 235 -54.307 7.709 -54.536 1.00 43.07 N \\\\nATOM 1858 OE1 GLN A 235 -55.570 9.491 -54.427 1.00 43.07 O \\\\nATOM 1859 N GLN A 236 -52.828 14.231 -51.848 1.00 40.77 N \\\\nATOM 1860 CA GLN A 236 -53.079 14.661 -53.225 1.00 40.77 C \\\\nATOM 1861 C GLN A 236 -52.575 16.115 -53.450 1.00 40.77 C \\\\nATOM 1862 CB GLN A 236 -54.617 14.612 -53.409 1.00 40.77 C \\\\nATOM 1863 O GLN A 236 -52.714 16.948 -52.564 1.00 40.77 O \\\\nATOM 1864 CG GLN A 236 -55.092 14.033 -54.742 1.00 40.77 C \\\\nATOM 1865 CD GLN A 236 -56.567 13.641 -54.715 1.00 40.77 C \\\\nATOM 1866 NE2 GLN A 236 -57.005 12.779 -55.602 1.00 40.77 N \\\\nATOM 1867 OE1 GLN A 236 -57.365 14.104 -53.921 1.00 40.77 O \\\\nATOM 1868 N LEU A 237 -51.998 16.353 -54.642 1.00 40.25 N \\\\nATOM 1869 CA LEU A 237 -51.968 17.543 -55.533 1.00 40.25 C \\\\nATOM 1870 C LEU A 237 -52.324 18.968 -55.019 1.00 40.25 C \\\\nATOM 1871 CB LEU A 237 -52.972 17.219 -56.665 1.00 40.25 C \\\\nATOM 1872 O LEU A 237 -53.214 19.127 -54.205 1.00 40.25 O \\\\nATOM 1873 CG LEU A 237 -52.494 16.164 -57.685 1.00 40.25 C \\\\nATOM 1874 CD1 LEU A 237 -53.184 14.814 -57.499 1.00 40.25 C \\\\nATOM 1875 CD2 LEU A 237 -52.813 16.621 -59.108 1.00 40.25 C \\\\nATOM 1876 N ASN A 238 -51.915 20.102 -55.611 1.00 38.01 N \\\\nATOM 1877 CA ASN A 238 -50.938 20.586 -56.609 1.00 38.01 C \\\\nATOM 1878 C ASN A 238 -51.364 22.056 -56.911 1.00 38.01 C \\\\nATOM 1879 CB ASN A 238 -50.998 19.776 -57.931 1.00 38.01 C \\\\nATOM 1880 O ASN A 238 -52.565 22.311 -56.914 1.00 38.01 O \\\\nATOM 1881 CG ASN A 238 -49.783 19.919 -58.827 1.00 38.01 C \\\\nATOM 1882 ND2 ASN A 238 -49.811 19.335 -60.006 1.00 38.01 N \\\\nATOM 1883 OD1 ASN A 238 -48.781 20.517 -58.487 1.00 38.01 O \\\\nATOM 1884 N GLN A 239 -50.420 22.937 -57.292 1.00 40.11 N \\\\nATOM 1885 CA GLN A 239 -50.619 24.237 -58.001 1.00 40.11 C \\\\nATOM 1886 C GLN A 239 -51.303 25.383 -57.200 1.00 40.11 C \\\\nATOM 1887 CB GLN A 239 -51.318 23.941 -59.348 1.00 40.11 C \\\\nATOM 1888 O GLN A 239 -52.139 25.132 -56.350 1.00 40.11 O \\\\nATOM 1889 CG GLN A 239 -50.440 23.130 -60.314 1.00 40.11 C \\\\nATOM 1890 CD GLN A 239 -51.238 22.565 -61.483 1.00 40.11 C \\\\nATOM 1891 NE2 GLN A 239 -51.226 21.271 -61.713 1.00 40.11 N \\\\nATOM 1892 OE1 GLN A 239 -51.873 23.269 -62.241 1.00 40.11 O \\\\nATOM 1893 N SER A 240 -51.038 26.686 -57.365 1.00 43.35 N \\\\nATOM 1894 CA SER A 240 -50.202 27.499 -58.269 1.00 43.35 C \\\\nATOM 1895 C SER A 240 -50.144 28.959 -57.738 1.00 43.35 C \\\\nATOM 1896 CB SER A 240 -50.762 27.509 -59.706 1.00 43.35 C \\\\nATOM 1897 O SER A 240 -50.901 29.325 -56.844 1.00 43.35 O \\\\nATOM 1898 OG SER A 240 -52.158 27.305 -59.748 1.00 43.35 O \\\\nATOM 1899 N MET A 241 -49.217 29.754 -58.286 1.00 42.24 N \\\\nATOM 1900 CA MET A 241 -48.848 31.152 -57.975 1.00 42.24 C \\\\nATOM 1901 C MET A 241 -49.996 32.180 -58.075 1.00 42.24 C \\\\nATOM 1902 CB MET A 241 -47.796 31.564 -59.029 1.00 42.24 C \\\\nATOM 1903 O MET A 241 -50.863 32.002 -58.918 1.00 42.24 O \\\\nATOM 1904 CG MET A 241 -46.510 30.723 -59.019 1.00 42.24 C \\\\nATOM 1905 SD MET A 241 -45.467 30.947 -60.489 1.00 42.24 S \\\\nATOM 1906 CE MET A 241 -44.030 29.949 -60.015 1.00 42.24 C \\\\nATOM 1907 N ASP A 242 -49.936 33.283 -57.305 1.00 40.97 N \\\\nATOM 1908 CA ASP A 242 -49.971 34.649 -57.871 1.00 40.97 C \\\\nATOM 1909 C ASP A 242 -49.706 35.794 -56.863 1.00 40.97 C \\\\nATOM 1910 CB ASP A 242 -51.237 34.953 -58.711 1.00 40.97 C \\\\nATOM 1911 O ASP A 242 -49.965 35.727 -55.664 1.00 40.97 O \\\\nATOM 1912 CG ASP A 242 -51.029 34.730 -60.222 1.00 40.97 C \\\\nATOM 1913 OD1 ASP A 242 -49.864 34.851 -60.676 1.00 40.97 O \\\\nATOM 1914 OD2 ASP A 242 -52.042 34.530 -60.928 1.00 40.97 O \\\\nATOM 1915 N THR A 243 -49.128 36.839 -57.450 1.00 38.70 N \\\\nATOM 1916 CA THR A 243 -48.641 38.169 -57.038 1.00 38.70 C \\\\nATOM 1917 C THR A 243 -49.545 39.095 -56.201 1.00 38.70 C \\\\nATOM 1918 CB THR A 243 -48.421 38.931 -58.366 1.00 38.70 C \\\\nATOM 1919 O THR A 243 -50.746 39.164 -56.437 1.00 38.70 O \\\\nATOM 1920 CG2 THR A 243 -47.054 38.660 -58.985 1.00 38.70 C \\\\nATOM 1921 OG1 THR A 243 -49.362 38.545 -59.348 1.00 38.70 O \\\\nATOM 1922 N GLY A 244 -48.926 39.973 -55.383 1.00 39.50 N \\\\nATOM 1923 CA GLY A 244 -49.496 41.283 -54.995 1.00 39.50 C \\\\nATOM 1924 C GLY A 244 -49.025 41.882 -53.651 1.00 39.50 C \\\\nATOM 1925 O GLY A 244 -49.585 41.568 -52.609 1.00 39.50 O \\\\nATOM 1926 N SER A 245 -48.027 42.774 -53.675 1.00 42.65 N \\\\nATOM 1927 CA SER A 245 -47.559 43.641 -52.560 1.00 42.65 C \\\\nATOM 1928 C SER A 245 -48.484 44.872 -52.339 1.00 42.65 C \\\\nATOM 1929 CB SER A 245 -46.157 44.149 -52.950 1.00 42.65 C \\\\nATOM 1930 O SER A 245 -49.369 45.087 -53.164 1.00 42.65 O \\\\nATOM 1931 OG SER A 245 -45.287 43.109 -53.350 1.00 42.65 O \\\\nATOM 1932 N PRO A 246 -48.160 45.856 -51.462 1.00 43.21 N \\\\nATOM 1933 CA PRO A 246 -47.896 45.842 -50.010 1.00 43.21 C \\\\nATOM 1934 C PRO A 246 -48.722 46.921 -49.241 1.00 43.21 C \\\\nATOM 1935 CB PRO A 246 -46.411 46.213 -49.915 1.00 43.21 C \\\\nATOM 1936 O PRO A 246 -49.145 47.911 -49.832 1.00 43.21 O \\\\nATOM 1937 CG PRO A 246 -46.212 47.195 -51.082 1.00 43.21 C \\\\nATOM 1938 CD PRO A 246 -47.416 46.984 -52.009 1.00 43.21 C \\\\nATOM 1939 N ALA A 247 -48.870 46.811 -47.911 1.00 43.57 N \\\\nATOM 1940 CA ALA A 247 -49.324 47.925 -47.059 1.00 43.57 C \\\\nATOM 1941 C ALA A 247 -48.847 47.812 -45.588 1.00 43.57 C \\\\nATOM 1942 CB ALA A 247 -50.855 48.047 -47.127 1.00 43.57 C \\\\nATOM 1943 O ALA A 247 -49.112 46.824 -44.914 1.00 43.57 O \\\\nATOM 1944 N GLU A 248 -48.155 48.869 -45.145 1.00 39.39 N \\\\nATOM 1945 CA GLU A 248 -48.252 49.554 -43.837 1.00 39.39 C \\\\nATOM 1946 C GLU A 248 -47.778 48.893 -42.512 1.00 39.39 C \\\\nATOM 1947 CB GLU A 248 -49.618 50.255 -43.728 1.00 39.39 C \\\\nATOM 1948 O GLU A 248 -48.478 48.144 -41.844 1.00 39.39 O \\\\nATOM 1949 CG GLU A 248 -49.804 51.247 -44.896 1.00 39.39 C \\\\nATOM 1950 CD GLU A 248 -51.023 52.160 -44.732 1.00 39.39 C \\\\nATOM 1951 OE1 GLU A 248 -50.856 53.370 -45.004 1.00 39.39 O \\\\nATOM 1952 OE2 GLU A 248 -52.101 51.647 -44.362 1.00 39.39 O \\\\nATOM 1953 N LEU A 249 -46.569 49.313 -42.100 1.00 41.33 N \\\\nATOM 1954 CA LEU A 249 -46.170 49.896 -40.798 1.00 41.33 C \\\\nATOM 1955 C LEU A 249 -46.823 49.398 -39.486 1.00 41.33 C \\\\nATOM 1956 CB LEU A 249 -46.370 51.429 -40.891 1.00 41.33 C \\\\nATOM 1957 O LEU A 249 -47.955 49.752 -39.176 1.00 41.33 O \\\\nATOM 1958 CG LEU A 249 -45.467 52.162 -41.899 1.00 41.33 C \\\\nATOM 1959 CD1 LEU A 249 -46.013 53.561 -42.181 1.00 41.33 C \\\\nATOM 1960 CD2 LEU A 249 -44.037 52.303 -41.372 1.00 41.33 C \\\\nATOM 1961 N SER A 250 -46.004 48.805 -38.602 1.00 40.23 N \\\\nATOM 1962 CA SER A 250 -45.986 49.060 -37.140 1.00 40.23 C \\\\nATOM 1963 C SER A 250 -44.722 48.453 -36.493 1.00 40.23 C \\\\nATOM 1964 CB SER A 250 -47.207 48.455 -36.435 1.00 40.23 C \\\\nATOM 1965 O SER A 250 -44.469 47.267 -36.697 1.00 40.23 O \\\\nATOM 1966 OG SER A 250 -48.333 49.282 -36.627 1.00 40.23 O \\\\nATOM 1967 N PRO A 251 -43.913 49.201 -35.712 1.00 37.55 N \\\\nATOM 1968 CA PRO A 251 -42.774 48.652 -34.979 1.00 37.55 C \\\\nATOM 1969 C PRO A 251 -43.180 48.301 -33.541 1.00 37.55 C \\\\nATOM 1970 CB PRO A 251 -41.722 49.764 -35.026 1.00 37.55 C \\\\nATOM 1971 O PRO A 251 -43.771 49.122 -32.841 1.00 37.55 O \\\\nATOM 1972 CG PRO A 251 -42.560 51.046 -34.979 1.00 37.55 C \\\\nATOM 1973 CD PRO A 251 -43.921 50.653 -35.571 1.00 37.55 C \\\\nATOM 1974 N THR A 252 -42.853 47.104 -33.053 1.00 40.99 N \\\\nATOM 1975 CA THR A 252 -42.973 46.801 -31.617 1.00 40.99 C \\\\nATOM 1976 C THR A 252 -41.962 45.744 -31.171 1.00 40.99 C \\\\nATOM 1977 CB THR A 252 -44.410 46.432 -31.164 1.00 40.99 C \\\\nATOM 1978 O THR A 252 -42.014 44.586 -31.566 1.00 40.99 O \\\\nATOM 1979 CG2 THR A 252 -44.923 47.403 -30.096 1.00 40.99 C \\\\nATOM 1980 OG1 THR A 252 -45.352 46.526 -32.205 1.00 40.99 O \\\\nATOM 1981 N THR A 253 -41.062 46.204 -30.295 1.00 40.72 N \\\\nATOM 1982 CA THR A 253 -40.430 45.482 -29.175 1.00 40.72 C \\\\nATOM 1983 C THR A 253 -39.524 44.280 -29.471 1.00 40.72 C \\\\nATOM 1984 CB THR A 253 -41.461 45.163 -28.079 1.00 40.72 C \\\\nATOM 1985 O THR A 253 -39.961 43.140 -29.593 1.00 40.72 O \\\\nATOM 1986 CG2 THR A 253 -41.946 46.453 -27.410 1.00 40.72 C \\\\nATOM 1987 OG1 THR A 253 -42.597 44.519 -28.600 1.00 40.72 O \\\\nATOM 1988 N LEU A 254 -38.216 44.561 -29.424 1.00 39.36 N \\\\nATOM 1989 CA LEU A 254 -37.133 43.610 -29.166 1.00 39.36 C \\\\nATOM 1990 C LEU A 254 -37.409 42.817 -27.876 1.00 39.36 C \\\\nATOM 1991 CB LEU A 254 -35.824 44.415 -29.003 1.00 39.36 C \\\\nATOM 1992 O LEU A 254 -37.460 43.395 -26.791 1.00 39.36 O \\\\nATOM 1993 CG LEU A 254 -35.280 45.017 -30.315 1.00 39.36 C \\\\nATOM 1994 CD1 LEU A 254 -34.831 46.466 -30.117 1.00 39.36 C \\\\nATOM 1995 CD2 LEU A 254 -34.086 44.210 -30.824 1.00 39.36 C \\\\nATOM 1996 N SER A 255 -37.551 41.499 -28.001 1.00 41.25 N \\\\nATOM 1997 CA SER A 255 -37.453 40.555 -26.882 1.00 41.25 C \\\\nATOM 1998 C SER A 255 -36.006 40.052 -26.797 1.00 41.25 C \\\\nATOM 1999 CB SER A 255 -38.413 39.381 -27.082 1.00 41.25 C \\\\nATOM 2000 O SER A 255 -35.414 39.783 -27.845 1.00 41.25 O \\\\nATOM 2001 OG SER A 255 -39.740 39.860 -27.175 1.00 41.25 O \\\\nATOM 2002 N PRO A 256 -35.403 39.934 -25.602 1.00 41.93 N \\\\nATOM 2003 CA PRO A 256 -34.027 39.477 -25.476 1.00 41.93 C \\\\nATOM 2004 C PRO A 256 -33.949 37.988 -25.824 1.00 41.93 C \\\\nATOM 2005 CB PRO A 256 -33.620 39.791 -24.034 1.00 41.93 C \\\\nATOM 2006 O PRO A 256 -34.719 37.173 -25.314 1.00 41.93 O \\\\nATOM 2007 CG PRO A 256 -34.942 39.739 -23.267 1.00 41.93 C \\\\nATOM 2008 CD PRO A 256 -35.998 40.152 -24.294 1.00 41.93 C \\\\nATOM 2009 N VAL A 257 -33.012 37.640 -26.704 1.00 38.71 N \\\\nATOM 2010 CA VAL A 257 -32.677 36.258 -27.054 1.00 38.71 C \\\\nATOM 2011 C VAL A 257 -32.097 35.594 -25.803 1.00 38.71 C \\\\nATOM 2012 CB VAL A 257 -31.690 36.217 -28.246 1.00 38.71 C \\\\nATOM 2013 O VAL A 257 -30.939 35.808 -25.450 1.00 38.71 O \\\\nATOM 2014 CG1 VAL A 257 -31.494 34.785 -28.757 1.00 38.71 C \\\\nATOM 2015 CG2 VAL A 257 -32.192 37.068 -29.424 1.00 38.71 C \\\\nATOM 2016 N ASN A 258 -32.916 34.816 -25.092 1.00 38.20 N \\\\nATOM 2017 CA ASN A 258 -32.433 33.894 -24.070 1.00 38.20 C \\\\nATOM 2018 C ASN A 258 -31.664 32.778 -24.786 1.00 38.20 C \\\\nATOM 2019 CB ASN A 258 -33.611 33.347 -23.225 1.00 38.20 C \\\\nATOM 2020 O ASN A 258 -32.248 31.774 -25.190 1.00 38.20 O \\\\nATOM 2021 CG ASN A 258 -33.801 34.022 -21.876 1.00 38.20 C \\\\nATOM 2022 ND2 ASN A 258 -34.835 33.652 -21.157 1.00 38.20 N \\\\nATOM 2023 OD1 ASN A 258 -33.028 34.845 -21.420 1.00 38.20 O \\\\nATOM 2024 N HIS A 259 -30.350 32.941 -24.936 1.00 43.97 N \\\\nATOM 2025 CA HIS A 259 -29.453 31.814 -25.172 1.00 43.97 C \\\\nATOM 2026 C HIS A 259 -29.431 30.956 -23.899 1.00 43.97 C \\\\nATOM 2027 CB HIS A 259 -28.052 32.306 -25.574 1.00 43.97 C \\\\nATOM 2028 O HIS A 259 -28.532 31.072 -23.068 1.00 43.97 O \\\\nATOM 2029 CG HIS A 259 -27.983 32.894 -26.961 1.00 43.97 C \\\\nATOM 2030 CD2 HIS A 259 -27.892 34.221 -27.283 1.00 43.97 C \\\\nATOM 2031 ND1 HIS A 259 -27.951 32.189 -28.145 1.00 43.97 N \\\\nATOM 2032 CE1 HIS A 259 -27.839 33.070 -29.153 1.00 43.97 C \\\\nATOM 2033 NE2 HIS A 259 -27.810 34.324 -28.674 1.00 43.97 N \\\\nATOM 2034 N SER A 260 -30.452 30.116 -23.702 1.00 46.85 N \\\\nATOM 2035 CA SER A 260 -30.347 29.020 -22.745 1.00 46.85 C \\\\nATOM 2036 C SER A 260 -29.341 28.033 -23.325 1.00 46.85 C \\\\nATOM 2037 CB SER A 260 -31.703 28.365 -22.442 1.00 46.85 C \\\\nATOM 2038 O SER A 260 -29.677 27.256 -24.218 1.00 46.85 O \\\\nATOM 2039 OG SER A 260 -32.255 27.717 -23.567 1.00 46.85 O \\\\nATOM 2040 N LEU A 261 -28.090 28.107 -22.870 1.00 57.93 N \\\\nATOM 2041 CA LEU A 261 -27.111 27.052 -23.102 1.00 57.93 C \\\\nATOM 2042 C LEU A 261 -27.748 25.739 -22.633 1.00 57.93 C \\\\nATOM 2043 CB LEU A 261 -25.818 27.369 -22.324 1.00 57.93 C \\\\nATOM 2044 O LEU A 261 -28.035 25.584 -21.445 1.00 57.93 O \\\\nATOM 2045 CG LEU A 261 -25.012 28.555 -22.887 1.00 57.93 C \\\\nATOM 2046 CD1 LEU A 261 -23.962 29.004 -21.869 1.00 57.93 C \\\\nATOM 2047 CD2 LEU A 261 -24.291 28.181 -24.185 1.00 57.93 C \\\\nATOM 2048 N ASP A 262 -28.031 24.838 -23.573 1.00 70.10 N \\\\nATOM 2049 CA ASP A 262 -28.588 23.519 -23.283 1.00 70.10 C \\\\nATOM 2050 C ASP A 262 -27.473 22.683 -22.635 1.00 70.10 C \\\\nATOM 2051 CB ASP A 262 -29.195 22.914 -24.566 1.00 70.10 C \\\\nATOM 2052 O ASP A 262 -26.625 22.085 -23.302 1.00 70.10 O \\\\nATOM 2053 CG ASP A 262 -30.120 21.714 -24.313 1.00 70.10 C \\\\nATOM 2054 OD1 ASP A 262 -30.649 21.595 -23.187 1.00 70.10 O \\\\nATOM 2055 OD2 ASP A 262 -30.301 20.904 -25.257 1.00 70.10 O \\\\nATOM 2056 N LEU A 263 -27.388 22.779 -21.307 1.00 79.04 N \\\\nATOM 2057 CA LEU A 263 -26.398 22.100 -20.479 1.00 79.04 C \\\\nATOM 2058 C LEU A 263 -26.907 20.697 -20.144 1.00 79.04 C \\\\nATOM 2059 CB LEU A 263 -26.142 22.921 -19.199 1.00 79.04 C \\\\nATOM 2060 O LEU A 263 -27.904 20.543 -19.438 1.00 79.04 O \\\\nATOM 2061 CG LEU A 263 -25.343 24.222 -19.402 1.00 79.04 C \\\\nATOM 2062 CD1 LEU A 263 -25.410 25.078 -18.136 1.00 79.04 C \\\\nATOM 2063 CD2 LEU A 263 -23.866 23.953 -19.694 1.00 79.04 C \\\\nATOM 2064 N GLN A 264 -26.191 19.668 -20.593 1.00 82.84 N \\\\nATOM 2065 CA GLN A 264 -26.520 18.281 -20.275 1.00 82.84 C \\\\nATOM 2066 C GLN A 264 -25.827 17.858 -18.964 1.00 82.84 C \\\\nATOM 2067 CB GLN A 264 -26.128 17.375 -21.451 1.00 82.84 C \\\\nATOM 2068 O GLN A 264 -24.595 17.875 -18.900 1.00 82.84 O \\\\nATOM 2069 CG GLN A 264 -26.586 15.919 -21.255 1.00 82.84 C \\\\nATOM 2070 CD GLN A 264 -28.099 15.731 -21.323 1.00 82.84 C \\\\nATOM 2071 NE2 GLN A 264 -28.653 14.767 -20.625 1.00 82.84 N \\\\nATOM 2072 OE1 GLN A 264 -28.816 16.404 -22.041 1.00 82.84 O \\\\nATOM 2073 N PRO A 265 -26.566 17.436 -17.920 1.00 88.13 N \\\\nATOM 2074 CA PRO A 265 -25.963 16.916 -16.697 1.00 88.13 C \\\\nATOM 2075 C PRO A 265 -25.456 15.478 -16.887 1.00 88.13 C \\\\nATOM 2076 CB PRO A 265 -27.061 17.016 -15.634 1.00 88.13 C \\\\nATOM 2077 O PRO A 265 -26.204 14.589 -17.296 1.00 88.13 O \\\\nATOM 2078 CG PRO A 265 -28.351 16.862 -16.442 1.00 88.13 C \\\\nATOM 2079 CD PRO A 265 -28.015 17.515 -17.783 1.00 88.13 C \\\\nATOM 2080 N VAL A 266 -24.196 15.235 -16.522 1.00 88.49 N \\\\nATOM 2081 CA VAL A 266 -23.542 13.920 -16.544 1.00 88.49 C \\\\nATOM 2082 C VAL A 266 -23.222 13.471 -15.117 1.00 88.49 C \\\\nATOM 2083 CB VAL A 266 -22.277 13.943 -17.424 1.00 88.49 C \\\\nATOM 2084 O VAL A 266 -22.374 14.053 -14.434 1.00 88.49 O \\\\nATOM 2085 CG1 VAL A 266 -21.631 12.554 -17.454 1.00 88.49 C \\\\nATOM 2086 CG2 VAL A 266 -22.603 14.340 -18.870 1.00 88.49 C \\\\nATOM 2087 N THR A 267 -23.899 12.416 -14.658 1.00 89.40 N \\\\nATOM 2088 CA THR A 267 -23.777 11.883 -13.292 1.00 89.40 C \\\\nATOM 2089 C THR A 267 -22.712 10.789 -13.167 1.00 89.40 C \\\\nATOM 2090 CB THR A 267 -25.125 11.358 -12.769 1.00 89.40 C \\\\nATOM 2091 O THR A 267 -22.523 9.952 -14.059 1.00 89.40 O \\\\nATOM 2092 CG2 THR A 267 -26.161 12.469 -12.601 1.00 89.40 C \\\\nATOM 2093 OG1 THR A 267 -25.678 10.415 -13.657 1.00 89.40 O \\\\nATOM 2094 N TYR A 268 -22.040 10.769 -12.013 1.00 89.45 N \\\\nATOM 2095 CA TYR A 268 -21.136 9.689 -11.622 1.00 89.45 C \\\\nATOM 2096 C TYR A 268 -21.918 8.409 -11.295 1.00 89.45 C \\\\nATOM 2097 CB TYR A 268 -20.292 10.126 -10.418 1.00 89.45 C \\\\nATOM 2098 O TYR A 268 -22.978 8.457 -10.670 1.00 89.45 O \\\\nATOM 2099 CG TYR A 268 -19.250 9.105 -9.993 1.00 89.45 C \\\\nATOM 2100 CD1 TYR A 268 -19.514 8.182 -8.961 1.00 89.45 C \\\\nATOM 2101 CD2 TYR A 268 -18.001 9.084 -10.631 1.00 89.45 C \\\\nATOM 2102 CE1 TYR A 268 -18.526 7.253 -8.569 1.00 89.45 C \\\\nATOM 2103 CE2 TYR A 268 -17.000 8.186 -10.220 1.00 89.45 C \\\\nATOM 2104 OH TYR A 268 -16.280 6.389 -8.811 1.00 89.45 O \\\\nATOM 2105 CZ TYR A 268 -17.259 7.256 -9.192 1.00 89.45 C \\\\nATOM 2106 N SER A 269 -21.368 7.259 -11.680 1.00 85.81 N \\\\nATOM 2107 CA SER A 269 -21.863 5.937 -11.292 1.00 85.81 C \\\\nATOM 2108 C SER A 269 -20.695 5.073 -10.841 1.00 85.81 C \\\\nATOM 2109 CB SER A 269 -22.624 5.259 -12.439 1.00 85.81 C \\\\nATOM 2110 O SER A 269 -19.671 5.038 -11.516 1.00 85.81 O \\\\nATOM 2111 OG SER A 269 -21.890 5.242 -13.658 1.00 85.81 O \\\\nATOM 2112 N GLU A 270 -20.845 4.374 -9.718 1.00 86.25 N \\\\nATOM 2113 CA GLU A 270 -19.789 3.501 -9.206 1.00 86.25 C \\\\nATOM 2114 C GLU A 270 -19.738 2.192 -10.023 1.00 86.25 C \\\\nATOM 2115 CB GLU A 270 -20.010 3.232 -7.709 1.00 86.25 C \\\\nATOM 2116 O GLU A 270 -20.766 1.516 -10.152 1.00 86.25 O \\\\nATOM 2117 CG GLU A 270 -18.728 2.796 -6.984 1.00 86.25 C \\\\nATOM 2118 CD GLU A 270 -17.764 3.974 -6.775 1.00 86.25 C \\\\nATOM 2119 OE1 GLU A 270 -16.707 4.031 -7.432 1.00 86.25 O \\\\nATOM 2120 OE2 GLU A 270 -18.057 4.870 -5.955 1.00 86.25 O \\\\nATOM 2121 N PRO A 271 -18.581 1.815 -10.592 1.00 91.14 N \\\\nATOM 2122 CA PRO A 271 -18.441 0.578 -11.353 1.00 91.14 C \\\\nATOM 2123 C PRO A 271 -18.353 -0.655 -10.440 1.00 91.14 C \\\\nATOM 2124 CB PRO A 271 -17.169 0.768 -12.180 1.00 91.14 C \\\\nATOM 2125 O PRO A 271 -17.957 -0.569 -9.280 1.00 91.14 O \\\\nATOM 2126 CG PRO A 271 -16.321 1.650 -11.272 1.00 91.14 C \\\\nATOM 2127 CD PRO A 271 -17.340 2.574 -10.621 1.00 91.14 C \\\\nATOM 2128 N ALA A 272 -18.644 -1.837 -10.995 1.00 89.84 N \\\\nATOM 2129 CA ALA A 272 -18.530 -3.114 -10.275 1.00 89.84 C \\\\nATOM 2130 C ALA A 272 -17.092 -3.431 -9.816 1.00 89.84 C \\\\nATOM 2131 CB ALA A 272 -19.057 -4.227 -11.189 1.00 89.84 C \\\\nATOM 2132 O ALA A 272 -16.889 -4.063 -8.781 1.00 89.84 O \\\\nATOM 2133 N PHE A 273 -16.099 -2.982 -10.588 1.00 94.27 N \\\\nATOM 2134 CA PHE A 273 -14.688 -3.017 -10.220 1.00 94.27 C \\\\nATOM 2135 C PHE A 273 -14.194 -1.585 -10.114 1.00 94.27 C \\\\nATOM 2136 CB PHE A 273 -13.874 -3.797 -11.260 1.00 94.27 C \\\\nATOM 2137 O PHE A 273 -14.209 -0.868 -11.114 1.00 94.27 O \\\\nATOM 2138 CG PHE A 273 -14.326 -5.227 -11.449 1.00 94.27 C \\\\nATOM 2139 CD1 PHE A 273 -13.887 -6.225 -10.564 1.00 94.27 C \\\\nATOM 2140 CD2 PHE A 273 -15.184 -5.565 -12.512 1.00 94.27 C \\\\nATOM 2141 CE1 PHE A 273 -14.299 -7.557 -10.732 1.00 94.27 C \\\\nATOM 2142 CE2 PHE A 273 -15.603 -6.897 -12.679 1.00 94.27 C \\\\nATOM 2143 CZ PHE A 273 -15.162 -7.892 -11.790 1.00 94.27 C \\\\nATOM 2144 N TRP A 274 -13.742 -1.160 -8.939 1.00 95.07 N \\\\nATOM 2145 CA TRP A 274 -13.333 0.229 -8.720 1.00 95.07 C \\\\nATOM 2146 C TRP A 274 -11.968 0.541 -9.349 1.00 95.07 C \\\\nATOM 2147 CB TRP A 274 -13.369 0.531 -7.223 1.00 95.07 C \\\\nATOM 2148 O TRP A 274 -11.717 1.679 -9.749 1.00 95.07 O \\\\nATOM 2149 CG TRP A 274 -12.348 -0.198 -6.411 1.00 95.07 C \\\\nATOM 2150 CD1 TRP A 274 -12.518 -1.390 -5.799 1.00 95.07 C \\\\nATOM 2151 CD2 TRP A 274 -10.987 0.221 -6.105 1.00 95.07 C \\\\nATOM 2152 CE2 TRP A 274 -10.390 -0.761 -5.262 1.00 95.07 C \\\\nATOM 2153 CE3 TRP A 274 -10.209 1.350 -6.438 1.00 95.07 C \\\\nATOM 2154 NE1 TRP A 274 -11.364 -1.725 -5.122 1.00 95.07 N \\\\nATOM 2155 CH2 TRP A 274 -8.338 0.512 -5.116 1.00 95.07 C \\\\nATOM 2156 CZ2 TRP A 274 -9.095 -0.612 -4.746 1.00 95.07 C \\\\nATOM 2157 CZ3 TRP A 274 -8.892 1.487 -5.963 1.00 95.07 C \\\\nATOM 2158 N CYS A 275 -11.102 -0.468 -9.505 1.00 97.41 N \\\\nATOM 2159 CA CYS A 275 -9.862 -0.335 -10.263 1.00 97.41 C \\\\nATOM 2160 C CYS A 275 -9.446 -1.606 -11.010 1.00 97.41 C \\\\nATOM 2161 CB CYS A 275 -8.727 0.177 -9.357 1.00 97.41 C \\\\nATOM 2162 O CYS A 275 -9.892 -2.718 -10.710 1.00 97.41 O \\\\nATOM 2163 SG CYS A 275 -8.172 -1.078 -8.170 1.00 97.41 S \\\\nATOM 2164 N SER A 276 -8.544 -1.421 -11.972 1.00 97.86 N \\\\nATOM 2165 CA SER A 276 -7.793 -2.494 -12.626 1.00 97.86 C \\\\nATOM 2166 C SER A 276 -6.289 -2.268 -12.470 1.00 97.86 C \\\\nATOM 2167 CB SER A 276 -8.208 -2.627 -14.092 1.00 97.86 C \\\\nATOM 2168 O SER A 276 -5.836 -1.124 -12.540 1.00 97.86 O \\\\nATOM 2169 OG SER A 276 -7.734 -1.550 -14.869 1.00 97.86 O \\\\nATOM 2170 N ILE A 277 -5.524 -3.339 -12.253 1.00 98.47 N \\\\nATOM 2171 CA ILE A 277 -4.088 -3.291 -11.952 1.00 98.47 C \\\\nATOM 2172 C ILE A 277 -3.315 -4.126 -12.969 1.00 98.47 C \\\\nATOM 2173 CB ILE A 277 -3.763 -3.772 -10.515 1.00 98.47 C \\\\nATOM 2174 O ILE A 277 -3.540 -5.331 -13.081 1.00 98.47 O \\\\nATOM 2175 CG1 ILE A 277 -4.882 -3.422 -9.506 1.00 98.47 C \\\\nATOM 2176 CG2 ILE A 277 -2.366 -3.251 -10.127 1.00 98.47 C \\\\nATOM 2177 CD1 ILE A 277 -4.496 -3.473 -8.027 1.00 98.47 C \\\\nATOM 2178 N ALA A 278 -2.370 -3.509 -13.673 1.00 98.55 N \\\\nATOM 2179 CA ALA A 278 -1.424 -4.200 -14.544 1.00 98.55 C \\\\nATOM 2180 C ALA A 278 -0.030 -4.218 -13.905 1.00 98.55 C \\\\nATOM 2181 CB ALA A 278 -1.436 -3.533 -15.922 1.00 98.55 C \\\\nATOM 2182 O ALA A 278 0.429 -3.200 -13.390 1.00 98.55 O \\\\nATOM 2183 N TYR A 279 0.645 -5.369 -13.934 1.00 98.63 N \\\\nATOM 2184 CA TYR A 279 2.011 -5.519 -13.431 1.00 98.63 C \\\\nATOM 2185 C TYR A 279 3.033 -5.476 -14.565 1.00 98.63 C \\\\nATOM 2186 CB TYR A 279 2.130 -6.801 -12.598 1.00 98.63 C \\\\nATOM 2187 O TYR A 279 2.824 -6.041 -15.641 1.00 98.63 O \\\\nATOM 2188 CG TYR A 279 3.542 -7.114 -12.125 1.00 98.63 C \\\\nATOM 2189 CD1 TYR A 279 4.171 -8.309 -12.518 1.00 98.63 C \\\\nATOM 2190 CD2 TYR A 279 4.229 -6.208 -11.296 1.00 98.63 C \\\\nATOM 2191 CE1 TYR A 279 5.469 -8.611 -12.068 1.00 98.63 C \\\\nATOM 2192 CE2 TYR A 279 5.536 -6.493 -10.858 1.00 98.63 C \\\\nATOM 2193 OH TYR A 279 7.386 -8.020 -10.749 1.00 98.63 O \\\\nATOM 2194 CZ TYR A 279 6.152 -7.707 -11.229 1.00 98.63 C \\\\nATOM 2195 N TYR A 280 4.157 -4.820 -14.295 1.00 98.73 N \\\\nATOM 2196 CA TYR A 280 5.253 -4.645 -15.227 1.00 98.73 C \\\\nATOM 2197 C TYR A 280 6.598 -4.950 -14.563 1.00 98.73 C \\\\nATOM 2198 CB TYR A 280 5.235 -3.217 -15.775 1.00 98.73 C \\\\nATOM 2199 O TYR A 280 6.865 -4.613 -13.403 1.00 98.73 O \\\\nATOM 2200 CG TYR A 280 4.056 -2.864 -16.663 1.00 98.73 C \\\\nATOM 2201 CD1 TYR A 280 4.181 -2.933 -18.064 1.00 98.73 C \\\\nATOM 2202 CD2 TYR A 280 2.855 -2.401 -16.090 1.00 98.73 C \\\\nATOM 2203 CE1 TYR A 280 3.098 -2.569 -18.890 1.00 98.73 C \\\\nATOM 2204 CE2 TYR A 280 1.780 -2.014 -16.913 1.00 98.73 C \\\\nATOM 2205 OH TYR A 280 0.868 -1.716 -19.113 1.00 98.73 O \\\\nATOM 2206 CZ TYR A 280 1.896 -2.105 -18.315 1.00 98.73 C \\\\nATOM 2207 N GLU A 281 7.479 -5.555 -15.351 1.00 98.51 N \\\\nATOM 2208 CA GLU A 281 8.898 -5.694 -15.056 1.00 98.51 C \\\\nATOM 2209 C GLU A 281 9.661 -4.903 -16.118 1.00 98.51 C \\\\nATOM 2210 CB GLU A 281 9.305 -7.179 -15.015 1.00 98.51 C \\\\nATOM 2211 O GLU A 281 9.632 -5.253 -17.297 1.00 98.51 O \\\\nATOM 2212 CG GLU A 281 8.652 -7.916 -13.832 1.00 98.51 C \\\\nATOM 2213 CD GLU A 281 8.992 -9.413 -13.731 1.00 98.51 C \\\\nATOM 2214 OE1 GLU A 281 8.462 -10.094 -12.822 1.00 98.51 O \\\\nATOM 2215 OE2 GLU A 281 9.816 -9.955 -14.502 1.00 98.51 O \\\\nATOM 2216 N LEU A 282 10.322 -3.812 -15.716 1.00 97.97 N \\\\nATOM 2217 CA LEU A 282 10.910 -2.843 -16.646 1.00 97.97 C \\\\nATOM 2218 C LEU A 282 9.847 -2.264 -17.600 1.00 97.97 C \\\\nATOM 2219 CB LEU A 282 12.144 -3.445 -17.358 1.00 97.97 C \\\\nATOM 2220 O LEU A 282 8.870 -1.684 -17.146 1.00 97.97 O \\\\nATOM 2221 CG LEU A 282 13.223 -3.999 -16.419 1.00 97.97 C \\\\nATOM 2222 CD1 LEU A 282 14.239 -4.800 -17.230 1.00 97.97 C \\\\nATOM 2223 CD2 LEU A 282 13.966 -2.879 -15.685 1.00 97.97 C \\\\nATOM 2224 N ASN A 283 10.004 -2.398 -18.913 1.00 97.02 N \\\\nATOM 2225 CA ASN A 283 9.026 -1.967 -19.914 1.00 97.02 C \\\\nATOM 2226 C ASN A 283 8.091 -3.098 -20.380 1.00 97.02 C \\\\nATOM 2227 CB ASN A 283 9.777 -1.319 -21.090 1.00 97.02 C \\\\nATOM 2228 O ASN A 283 7.291 -2.881 -21.287 1.00 97.02 O \\\\nATOM 2229 CG ASN A 283 10.673 -2.289 -21.843 1.00 97.02 C \\\\nATOM 2230 ND2 ASN A 283 10.969 -2.008 -23.087 1.00 97.02 N \\\\nATOM 2231 OD1 ASN A 283 11.151 -3.283 -21.320 1.00 97.02 O \\\\nATOM 2232 N GLN A 284 8.187 -4.297 -19.798 1.00 97.84 N \\\\nATOM 2233 CA GLN A 284 7.410 -5.460 -20.216 1.00 97.84 C \\\\nATOM 2234 C GLN A 284 6.244 -5.708 -19.260 1.00 97.84 C \\\\nATOM 2235 CB GLN A 284 8.342 -6.674 -20.321 1.00 97.84 C \\\\nATOM 2236 O GLN A 284 6.435 -5.811 -18.048 1.00 97.84 O \\\\nATOM 2237 CG GLN A 284 7.625 -7.885 -20.934 1.00 97.84 C \\\\nATOM 2238 CD GLN A 284 8.527 -9.101 -21.097 1.00 97.84 C \\\\nATOM 2239 NE2 GLN A 284 8.044 -10.153 -21.718 1.00 97.84 N \\\\nATOM 2240 OE1 GLN A 284 9.677 -9.143 -20.691 1.00 97.84 O \\\\nATOM 2241 N ARG A 285 5.033 -5.853 -19.806 1.00 98.04 N \\\\nATOM 2242 CA ARG A 285 3.860 -6.294 -19.041 1.00 98.04 C \\\\nATOM 2243 C ARG A 285 3.996 -7.771 -18.681 1.00 98.04 C \\\\nATOM 2244 CB ARG A 285 2.586 -6.010 -19.841 1.00 98.04 C \\\\nATOM 2245 O ARG A 285 4.353 -8.586 -19.531 1.00 98.04 O \\\\nATOM 2246 CG ARG A 285 1.316 -6.279 -19.020 1.00 98.04 C \\\\nATOM 2247 CD ARG A 285 0.115 -5.771 -19.815 1.00 98.04 C \\\\nATOM 2248 NE ARG A 285 -1.167 -6.187 -19.224 1.00 98.04 N \\\\nATOM 2249 NH1 ARG A 285 -2.464 -5.493 -20.990 1.00 98.04 N \\\\nATOM 2250 NH2 ARG A 285 -3.411 -6.566 -19.315 1.00 98.04 N \\\\nATOM 2251 CZ ARG A 285 -2.332 -6.079 -19.834 1.00 98.04 C \\\\nATOM 2252 N VAL A 286 3.700 -8.113 -17.432 1.00 98.24 N \\\\nATOM 2253 CA VAL A 286 3.852 -9.466 -16.892 1.00 98.24 C \\\\nATOM 2254 C VAL A 286 2.558 -9.890 -16.201 1.00 98.24 C \\\\nATOM 2255 CB VAL A 286 5.064 -9.534 -15.940 1.00 98.24 C \\\\nATOM 2256 O VAL A 286 2.137 -9.270 -15.229 1.00 98.24 O \\\\nATOM 2257 CG1 VAL A 286 5.211 -10.922 -15.307 1.00 98.24 C \\\\nATOM 2258 CG2 VAL A 286 6.374 -9.224 -16.675 1.00 98.24 C \\\\nATOM 2259 N GLY A 287 1.964 -10.987 -16.673 1.00 96.53 N \\\\nATOM 2260 CA GLY A 287 0.712 -11.524 -16.137 1.00 96.53 C \\\\nATOM 2261 C GLY A 287 -0.550 -10.832 -16.658 1.00 96.53 C \\\\nATOM 2262 O GLY A 287 -0.506 -9.941 -17.509 1.00 96.53 O \\\\nATOM 2263 N GLU A 288 -1.691 -11.282 -16.143 1.00 95.82 N \\\\nATOM 2264 CA GLU A 288 -3.015 -10.746 -16.466 1.00 95.82 C \\\\nATOM 2265 C GLU A 288 -3.318 -9.466 -15.673 1.00 95.82 C \\\\nATOM 2266 CB GLU A 288 -4.087 -11.816 -16.208 1.00 95.82 C \\\\nATOM 2267 O GLU A 288 -2.705 -9.190 -14.639 1.00 95.82 O \\\\nATOM 2268 CG GLU A 288 -3.880 -13.061 -17.087 1.00 95.82 C \\\\nATOM 2269 CD GLU A 288 -4.966 -14.124 -16.878 1.00 95.82 C \\\\nATOM 2270 OE1 GLU A 288 -5.203 -14.883 -17.841 1.00 95.82 O \\\\nATOM 2271 OE2 GLU A 288 -5.517 -14.185 -15.757 1.00 95.82 O \\\\nATOM 2272 N THR A 289 -4.281 -8.673 -16.151 1.00 97.10 N \\\\nATOM 2273 CA THR A 289 -4.793 -7.538 -15.371 1.00 97.10 C \\\\nATOM 2274 C THR A 289 -5.664 -8.040 -14.233 1.00 97.10 C \\\\nATOM 2275 CB THR A 289 -5.594 -6.550 -16.222 1.00 97.10 C \\\\nATOM 2276 O THR A 289 -6.643 -8.753 -14.450 1.00 97.10 O \\\\nATOM 2277 CG2 THR A 289 -6.231 -5.405 -15.443 1.00 97.10 C \\\\nATOM 2278 OG1 THR A 289 -4.718 -5.889 -17.089 1.00 97.10 O \\\\nATOM 2279 N PHE A 290 -5.354 -7.596 -13.022 1.00 96.97 N \\\\nATOM 2280 CA PHE A 290 -6.176 -7.846 -11.851 1.00 96.97 C \\\\nATOM 2281 C PHE A 290 -7.320 -6.830 -11.776 1.00 96.97 C \\\\nATOM 2282 CB PHE A 290 -5.278 -7.792 -10.620 1.00 96.97 C \\\\nATOM 2283 O PHE A 290 -7.086 -5.631 -11.914 1.00 96.97 O \\\\nATOM 2284 CG PHE A 290 -5.994 -8.160 -9.344 1.00 96.97 C \\\\nATOM 2285 CD1 PHE A 290 -6.638 -7.167 -8.583 1.00 96.97 C \\\\nATOM 2286 CD2 PHE A 290 -6.019 -9.502 -8.923 1.00 96.97 C \\\\nATOM 2287 CE1 PHE A 290 -7.286 -7.513 -7.387 1.00 96.97 C \\\\nATOM 2288 CE2 PHE A 290 -6.657 -9.847 -7.721 1.00 96.97 C \\\\nATOM 2289 CZ PHE A 290 -7.279 -8.850 -6.953 1.00 96.97 C \\\\nATOM 2290 N HIS A 291 -8.545 -7.287 -11.519 1.00 96.94 N \\\\nATOM 2291 CA HIS A 291 -9.725 -6.426 -11.405 1.00 96.94 C \\\\nATOM 2292 C HIS A 291 -10.249 -6.449 -9.969 1.00 96.94 C \\\\nATOM 2293 CB HIS A 291 -10.791 -6.861 -12.416 1.00 96.94 C \\\\nATOM 2294 O HIS A 291 -10.591 -7.504 -9.439 1.00 96.94 O \\\\nATOM 2295 CG HIS A 291 -10.338 -6.727 -13.848 1.00 96.94 C \\\\nATOM 2296 CD2 HIS A 291 -10.580 -5.670 -14.683 1.00 96.94 C \\\\nATOM 2297 ND1 HIS A 291 -9.591 -7.641 -14.559 1.00 96.94 N \\\\nATOM 2298 CE1 HIS A 291 -9.403 -7.152 -15.793 1.00 96.94 C \\\\nATOM 2299 NE2 HIS A 291 -9.971 -5.943 -15.910 1.00 96.94 N \\\\nATOM 2300 N ALA A 292 -10.304 -5.281 -9.332 1.00 94.85 N \\\\nATOM 2301 CA ALA A 292 -10.612 -5.160 -7.915 1.00 94.85 C \\\\nATOM 2302 C ALA A 292 -12.092 -4.856 -7.678 1.00 94.85 C \\\\nATOM 2303 CB ALA A 292 -9.737 -4.054 -7.345 1.00 94.85 C \\\\nATOM 2304 O ALA A 292 -12.557 -3.755 -7.970 1.00 94.85 O \\\\nATOM 2305 N SER A 293 -12.831 -5.824 -7.138 1.00 91.03 N \\\\nATOM 2306 CA SER A 293 -14.233 -5.637 -6.736 1.00 91.03 C \\\\nATOM 2307 C SER A 293 -14.364 -5.249 -5.264 1.00 91.03 C \\\\nATOM 2308 CB SER A 293 -15.029 -6.910 -7.021 1.00 91.03 C \\\\nATOM 2309 O SER A 293 -15.207 -4.432 -4.909 1.00 91.03 O \\\\nATOM 2310 OG SER A 293 -14.425 -8.035 -6.398 1.00 91.03 O \\\\nATOM 2311 N GLN A 294 -13.508 -5.801 -4.401 1.00 90.62 N \\\\nATOM 2312 CA GLN A 294 -13.521 -5.508 -2.970 1.00 90.62 C \\\\nATOM 2313 C GLN A 294 -12.933 -4.120 -2.681 1.00 90.62 C \\\\nATOM 2314 CB GLN A 294 -12.771 -6.602 -2.189 1.00 90.62 C \\\\nATOM 2315 O GLN A 294 -11.941 -3.742 -3.312 1.00 90.62 O \\\\nATOM 2316 CG GLN A 294 -13.435 -7.982 -2.320 1.00 90.62 C \\\\nATOM 2317 CD GLN A 294 -14.891 -7.991 -1.863 1.00 90.62 C \\\\nATOM 2318 NE2 GLN A 294 -15.742 -8.766 -2.496 1.00 90.62 N \\\\nATOM 2319 OE1 GLN A 294 -15.304 -7.279 -0.963 1.00 90.62 O \\\\nATOM 2320 N PRO A 295 -13.460 -3.378 -1.687 1.00 89.93 N \\\\nATOM 2321 CA PRO A 295 -12.981 -2.036 -1.345 1.00 89.93 C \\\\nATOM 2322 C PRO A 295 -11.551 -2.033 -0.797 1.00 89.93 C \\\\nATOM 2323 CB PRO A 295 -13.969 -1.515 -0.295 1.00 89.93 C \\\\nATOM 2324 O PRO A 295 -10.946 -0.978 -0.670 1.00 89.93 O \\\\nATOM 2325 CG PRO A 295 -14.477 -2.789 0.379 1.00 89.93 C \\\\nATOM 2326 CD PRO A 295 -14.529 -3.779 -0.780 1.00 89.93 C \\\\nATOM 2327 N SER A 296 -10.995 -3.195 -0.456 1.00 92.89 N \\\\nATOM 2328 CA SER A 296 -9.617 -3.358 -0.006 1.00 92.89 C \\\\nATOM 2329 C SER A 296 -8.981 -4.532 -0.741 1.00 92.89 C \\\\nATOM 2330 CB SER A 296 -9.600 -3.576 1.509 1.00 92.89 C \\\\nATOM 2331 O SER A 296 -9.544 -5.622 -0.763 1.00 92.89 O \\\\nATOM 2332 OG SER A 296 -8.313 -3.961 1.962 1.00 92.89 O \\\\nATOM 2333 N LEU A 297 -7.772 -4.335 -1.261 1.00 96.06 N \\\\nATOM 2334 CA LEU A 297 -6.951 -5.391 -1.853 1.00 96.06 C \\\\nATOM 2335 C LEU A 297 -5.479 -5.222 -1.463 1.00 96.06 C \\\\nATOM 2336 CB LEU A 297 -7.161 -5.421 -3.378 1.00 96.06 C \\\\nATOM 2337 O LEU A 297 -5.037 -4.141 -1.076 1.00 96.06 O \\\\nATOM 2338 CG LEU A 297 -6.436 -4.267 -4.101 1.00 96.06 C \\\\nATOM 2339 CD1 LEU A 297 -5.200 -4.773 -4.846 1.00 96.06 C \\\\nATOM 2340 CD2 LEU A 297 -7.335 -3.596 -5.117 1.00 96.06 C \\\\nATOM 2341 N THR A 298 -4.699 -6.290 -1.571 1.00 97.78 N \\\\nATOM 2342 CA THR A 298 -3.249 -6.266 -1.349 1.00 97.78 C \\\\nATOM 2343 C THR A 298 -2.525 -6.752 -2.597 1.00 97.78 C \\\\nATOM 2344 CB THR A 298 -2.871 -7.103 -0.118 1.00 97.78 C \\\\nATOM 2345 O THR A 298 -2.809 -7.838 -3.088 1.00 97.78 O \\\\nATOM 2346 CG2 THR A 298 -1.411 -6.913 0.276 1.00 97.78 C \\\\nATOM 2347 OG1 THR A 298 -3.663 -6.707 0.989 1.00 97.78 O \\\\nATOM 2348 N VAL A 299 -1.578 -5.969 -3.109 1.00 98.41 N \\\\nATOM 2349 CA VAL A 299 -0.645 -6.407 -4.154 1.00 98.41 C \\\\nATOM 2350 C VAL A 299 0.644 -6.826 -3.462 1.00 98.41 C \\\\nATOM 2351 CB VAL A 299 -0.384 -5.311 -5.202 1.00 98.41 C \\\\nATOM 2352 O VAL A 299 1.325 -5.978 -2.886 1.00 98.41 O \\\\nATOM 2353 CG1 VAL A 299 0.448 -5.885 -6.351 1.00 98.41 C \\\\nATOM 2354 CG2 VAL A 299 -1.672 -4.700 -5.766 1.00 98.41 C \\\\nATOM 2355 N ASP A 300 0.964 -8.118 -3.477 1.00 98.33 N \\\\nATOM 2356 CA ASP A 300 2.064 -8.694 -2.697 1.00 98.33 C \\\\nATOM 2357 C ASP A 300 2.994 -9.587 -3.532 1.00 98.33 C \\\\nATOM 2358 CB ASP A 300 1.516 -9.372 -1.427 1.00 98.33 C \\\\nATOM 2359 O ASP A 300 2.729 -9.896 -4.690 1.00 98.33 O \\\\nATOM 2360 CG ASP A 300 0.725 -10.659 -1.648 1.00 98.33 C \\\\nATOM 2361 OD1 ASP A 300 1.220 -11.561 -2.354 1.00 98.33 O \\\\nATOM 2362 OD2 ASP A 300 -0.292 -10.861 -0.942 1.00 98.33 O \\\\nATOM 2363 N GLY A 301 4.136 -9.963 -2.957 1.00 97.82 N \\\\nATOM 2364 CA GLY A 301 5.156 -10.794 -3.602 1.00 97.82 C \\\\nATOM 2365 C GLY A 301 4.979 -12.297 -3.375 1.00 97.82 C \\\\nATOM 2366 O GLY A 301 5.909 -13.049 -3.660 1.00 97.82 O \\\\nATOM 2367 N PHE A 302 3.843 -12.743 -2.830 1.00 97.35 N \\\\nATOM 2368 CA PHE A 302 3.573 -14.155 -2.546 1.00 97.35 C \\\\nATOM 2369 C PHE A 302 2.885 -14.841 -3.740 1.00 97.35 C \\\\nATOM 2370 CB PHE A 302 2.783 -14.263 -1.232 1.00 97.35 C \\\\nATOM 2371 O PHE A 302 2.907 -14.325 -4.856 1.00 97.35 O \\\\nATOM 2372 CG PHE A 302 3.435 -13.594 -0.030 1.00 97.35 C \\\\nATOM 2373 CD1 PHE A 302 4.690 -14.039 0.428 1.00 97.35 C \\\\nATOM 2374 CD2 PHE A 302 2.791 -12.539 0.644 1.00 97.35 C \\\\nATOM 2375 CE1 PHE A 302 5.291 -13.437 1.547 1.00 97.35 C \\\\nATOM 2376 CE2 PHE A 302 3.385 -11.946 1.771 1.00 97.35 C \\\\nATOM 2377 CZ PHE A 302 4.638 -12.392 2.223 1.00 97.35 C \\\\nATOM 2378 N THR A 303 2.335 -16.044 -3.546 1.00 96.72 N \\\\nATOM 2379 CA THR A 303 1.984 -16.964 -4.647 1.00 96.72 C \\\\nATOM 2380 C THR A 303 0.567 -17.547 -4.562 1.00 96.72 C \\\\nATOM 2381 CB THR A 303 3.019 -18.101 -4.740 1.00 96.72 C \\\\nATOM 2382 O THR A 303 0.355 -18.666 -5.015 1.00 96.72 O \\\\nATOM 2383 CG2 THR A 303 4.447 -17.610 -4.978 1.00 96.72 C \\\\nATOM 2384 OG1 THR A 303 3.013 -18.832 -3.534 1.00 96.72 O \\\\nATOM 2385 N ASP A 304 -0.398 -16.851 -3.956 1.00 94.15 N \\\\nATOM 2386 CA ASP A 304 -1.798 -17.309 -3.915 1.00 94.15 C \\\\nATOM 2387 C ASP A 304 -2.532 -16.889 -5.205 1.00 94.15 C \\\\nATOM 2388 CB ASP A 304 -2.473 -16.747 -2.658 1.00 94.15 C \\\\nATOM 2389 O ASP A 304 -2.710 -15.693 -5.423 1.00 94.15 O \\\\nATOM 2390 CG ASP A 304 -3.936 -17.159 -2.451 1.00 94.15 C \\\\nATOM 2391 OD1 ASP A 304 -4.527 -17.856 -3.318 1.00 94.15 O \\\\nATOM 2392 OD2 ASP A 304 -4.436 -16.746 -1.375 1.00 94.15 O \\\\nATOM 2393 N PRO A 305 -2.946 -17.827 -6.077 1.00 91.29 N \\\\nATOM 2394 CA PRO A 305 -3.564 -17.491 -7.360 1.00 91.29 C \\\\nATOM 2395 C PRO A 305 -5.070 -17.204 -7.267 1.00 91.29 C \\\\nATOM 2396 CB PRO A 305 -3.296 -18.721 -8.232 1.00 91.29 C \\\\nATOM 2397 O PRO A 305 -5.663 -16.781 -8.252 1.00 91.29 O \\\\nATOM 2398 CG PRO A 305 -3.376 -19.872 -7.230 1.00 91.29 C \\\\nATOM 2399 CD PRO A 305 -2.768 -19.270 -5.965 1.00 91.29 C \\\\nATOM 2400 N SER A 306 -5.711 -17.495 -6.131 1.00 88.57 N \\\\nATOM 2401 CA SER A 306 -7.172 -17.684 -6.059 1.00 88.57 C \\\\nATOM 2402 C SER A 306 -7.919 -16.630 -5.244 1.00 88.57 C \\\\nATOM 2403 CB SER A 306 -7.461 -19.087 -5.524 1.00 88.57 C \\\\nATOM 2404 O SER A 306 -9.147 -16.650 -5.163 1.00 88.57 O \\\\nATOM 2405 OG SER A 306 -6.983 -19.271 -4.198 1.00 88.57 O \\\\nATOM 2406 N ASN A 307 -7.193 -15.712 -4.614 1.00 87.96 N \\\\nATOM 2407 CA ASN A 307 -7.768 -14.765 -3.675 1.00 87.96 C \\\\nATOM 2408 C ASN A 307 -8.130 -13.440 -4.363 1.00 87.96 C \\\\nATOM 2409 CB ASN A 307 -6.780 -14.647 -2.514 1.00 87.96 C \\\\nATOM 2410 O ASN A 307 -7.258 -12.690 -4.791 1.00 87.96 O \\\\nATOM 2411 CG ASN A 307 -7.307 -13.822 -1.365 1.00 87.96 C \\\\nATOM 2412 ND2 ASN A 307 -6.954 -14.183 -0.156 1.00 87.96 N \\\\nATOM 2413 OD1 ASN A 307 -8.048 -12.869 -1.514 1.00 87.96 O \\\\nATOM 2414 N SER A 308 -9.423 -13.110 -4.406 1.00 89.03 N \\\\nATOM 2415 CA SER A 308 -9.940 -11.878 -5.023 1.00 89.03 C \\\\nATOM 2416 C SER A 308 -9.550 -10.582 -4.298 1.00 89.03 C \\\\nATOM 2417 CB SER A 308 -11.465 -11.960 -5.118 1.00 89.03 C \\\\nATOM 2418 O SER A 308 -9.783 -9.498 -4.821 1.00 89.03 O \\\\nATOM 2419 OG SER A 308 -12.037 -12.143 -3.834 1.00 89.03 O \\\\nATOM 2420 N GLU A 309 -8.983 -10.665 -3.094 1.00 92.14 N \\\\nATOM 2421 CA GLU A 309 -8.434 -9.529 -2.341 1.00 92.14 C \\\\nATOM 2422 C GLU A 309 -6.903 -9.457 -2.441 1.00 92.14 C \\\\nATOM 2423 CB GLU A 309 -8.846 -9.615 -0.863 1.00 92.14 C \\\\nATOM 2424 O GLU A 309 -6.290 -8.568 -1.843 1.00 92.14 O \\\\nATOM 2425 CG GLU A 309 -10.360 -9.535 -0.631 1.00 92.14 C \\\\nATOM 2426 CD GLU A 309 -10.740 -9.691 0.853 1.00 92.14 C \\\\nATOM 2427 OE1 GLU A 309 -11.953 -9.833 1.122 1.00 92.14 O \\\\nATOM 2428 OE2 GLU A 309 -9.837 -9.684 1.728 1.00 92.14 O \\\\nATOM 2429 N ARG A 310 -6.252 -10.390 -3.154 1.00 96.04 N \\\\nATOM 2430 CA ARG A 310 -4.791 -10.445 -3.258 1.00 96.04 C \\\\nATOM 2431 C ARG A 310 -4.327 -10.595 -4.697 1.00 96.04 C \\\\nATOM 2432 CB ARG A 310 -4.203 -11.564 -2.396 1.00 96.04 C \\\\nATOM 2433 O ARG A 310 -4.538 -11.619 -5.333 1.00 96.04 O \\\\nATOM 2434 CG ARG A 310 -4.527 -11.394 -0.906 1.00 96.04 C \\\\nATOM 2435 CD ARG A 310 -3.942 -12.550 -0.098 1.00 96.04 C \\\\nATOM 2436 NE ARG A 310 -2.472 -12.565 -0.148 1.00 96.04 N \\\\nATOM 2437 NH1 ARG A 310 -2.160 -14.826 0.181 1.00 96.04 N \\\\nATOM 2438 NH2 ARG A 310 -0.422 -13.452 -0.107 1.00 96.04 N \\\\nATOM 2439 CZ ARG A 310 -1.701 -13.620 -0.017 1.00 96.04 C \\\\nATOM 2440 N PHE A 311 -3.589 -9.599 -5.170 1.00 97.27 N \\\\nATOM 2441 CA PHE A 311 -2.848 -9.704 -6.414 1.00 97.27 C \\\\nATOM 2442 C PHE A 311 -1.417 -10.164 -6.116 1.00 97.27 C \\\\nATOM 2443 CB PHE A 311 -2.922 -8.385 -7.183 1.00 97.27 C \\\\nATOM 2444 O PHE A 311 -0.531 -9.370 -5.791 1.00 97.27 O \\\\nATOM 2445 CG PHE A 311 -2.310 -8.407 -8.574 1.00 97.27 C \\\\nATOM 2446 CD1 PHE A 311 -1.940 -7.188 -9.172 1.00 97.27 C \\\\nATOM 2447 CD2 PHE A 311 -2.148 -9.609 -9.300 1.00 97.27 C \\\\nATOM 2448 CE1 PHE A 311 -1.416 -7.167 -10.476 1.00 97.27 C \\\\nATOM 2449 CE2 PHE A 311 -1.618 -9.587 -10.599 1.00 97.27 C \\\\nATOM 2450 CZ PHE A 311 -1.255 -8.367 -11.190 1.00 97.27 C \\\\nATOM 2451 N CYS A 312 -1.209 -11.476 -6.173 1.00 97.36 N \\\\nATOM 2452 CA CYS A 312 0.056 -12.118 -5.839 1.00 97.36 C \\\\nATOM 2453 C CYS A 312 1.023 -12.116 -7.031 1.00 97.36 C \\\\nATOM 2454 CB CYS A 312 -0.262 -13.530 -5.345 1.00 97.36 C \\\\nATOM 2455 O CYS A 312 0.951 -12.957 -7.924 1.00 97.36 O \\\\nATOM 2456 SG CYS A 312 -0.905 -13.448 -3.650 1.00 97.36 S \\\\nATOM 2457 N LEU A 313 1.981 -11.193 -7.027 1.00 97.92 N \\\\nATOM 2458 CA LEU A 313 2.961 -11.027 -8.100 1.00 97.92 C \\\\nATOM 2459 C LEU A 313 3.986 -12.164 -8.147 1.00 97.92 C \\\\nATOM 2460 CB LEU A 313 3.682 -9.679 -7.923 1.00 97.92 C \\\\nATOM 2461 O LEU A 313 4.587 -12.400 -9.197 1.00 97.92 O \\\\nATOM 2462 CG LEU A 313 2.757 -8.448 -7.849 1.00 97.92 C \\\\nATOM 2463 CD1 LEU A 313 3.620 -7.194 -7.709 1.00 97.92 C \\\\nATOM 2464 CD2 LEU A 313 1.873 -8.320 -9.087 1.00 97.92 C \\\\nATOM 2465 N GLY A 314 4.205 -12.865 -7.030 1.00 97.10 N \\\\nATOM 2466 CA GLY A 314 5.233 -13.897 -6.866 1.00 97.10 C \\\\nATOM 2467 C GLY A 314 5.062 -15.102 -7.791 1.00 97.10 C \\\\nATOM 2468 O GLY A 314 6.067 -15.654 -8.237 1.00 97.10 O \\\\nATOM 2469 N LEU A 315 3.819 -15.453 -8.143 1.00 95.97 N \\\\nATOM 2470 CA LEU A 315 3.499 -16.566 -9.051 1.00 95.97 C \\\\nATOM 2471 C LEU A 315 3.662 -16.217 -10.539 1.00 95.97 C \\\\nATOM 2472 CB LEU A 315 2.086 -17.092 -8.729 1.00 95.97 C \\\\nATOM 2473 O LEU A 315 3.755 -17.111 -11.380 1.00 95.97 O \\\\nATOM 2474 CG LEU A 315 0.935 -16.120 -9.073 1.00 95.97 C \\\\nATOM 2475 CD1 LEU A 315 0.299 -16.433 -10.426 1.00 95.97 C \\\\nATOM 2476 CD2 LEU A 315 -0.157 -16.195 -8.008 1.00 95.97 C \\\\nATOM 2477 N LEU A 316 3.706 -14.925 -10.878 1.00 96.99 N \\\\nATOM 2478 CA LEU A 316 3.794 -14.481 -12.265 1.00 96.99 C \\\\nATOM 2479 C LEU A 316 5.173 -14.805 -12.842 1.00 96.99 C \\\\nATOM 2480 CB LEU A 316 3.471 -12.984 -12.385 1.00 96.99 C \\\\nATOM 2481 O LEU A 316 6.210 -14.418 -12.291 1.00 96.99 O \\\\nATOM 2482 CG LEU A 316 2.113 -12.561 -11.798 1.00 96.99 C \\\\nATOM 2483 CD1 LEU A 316 1.944 -11.053 -11.957 1.00 96.99 C \\\\nATOM 2484 CD2 LEU A 316 0.944 -13.261 -12.490 1.00 96.99 C \\\\nATOM 2485 N SER A 317 5.184 -15.500 -13.972 1.00 96.68 N \\\\nATOM 2486 CA SER A 317 6.404 -15.879 -14.683 1.00 96.68 C \\\\nATOM 2487 C SER A 317 6.768 -14.847 -15.747 1.00 96.68 C \\\\nATOM 2488 CB SER A 317 6.244 -17.279 -15.274 1.00 96.68 C \\\\nATOM 2489 O SER A 317 5.897 -14.247 -16.368 1.00 96.68 O \\\\nATOM 2490 OG SER A 317 6.150 -18.211 -14.215 1.00 96.68 O \\\\nATOM 2491 N ASN A 318 8.068 -14.645 -15.957 1.00 96.83 N \\\\nATOM 2492 CA ASN A 318 8.603 -13.826 -17.038 1.00 96.83 C \\\\nATOM 2493 C ASN A 318 9.930 -14.436 -17.500 1.00 96.83 C \\\\nATOM 2494 CB ASN A 318 8.779 -12.374 -16.559 1.00 96.83 C \\\\nATOM 2495 O ASN A 318 10.871 -14.531 -16.712 1.00 96.83 O \\\\nATOM 2496 CG ASN A 318 9.386 -11.484 -17.632 1.00 96.83 C \\\\nATOM 2497 ND2 ASN A 318 9.829 -10.306 -17.276 1.00 96.83 N \\\\nATOM 2498 OD1 ASN A 318 9.485 -11.850 -18.793 1.00 96.83 O \\\\nATOM 2499 N VAL A 319 10.000 -14.848 -18.766 1.00 97.17 N \\\\nATOM 2500 CA VAL A 319 11.196 -15.471 -19.359 1.00 97.17 C \\\\nATOM 2501 C VAL A 319 12.351 -14.482 -19.547 1.00 97.17 C \\\\nATOM 2502 CB VAL A 319 10.863 -16.166 -20.694 1.00 97.17 C \\\\nATOM 2503 O VAL A 319 13.506 -14.891 -19.538 1.00 97.17 O \\\\nATOM 2504 CG1 VAL A 319 9.882 -17.326 -20.475 1.00 97.17 C \\\\nATOM 2505 CG2 VAL A 319 10.269 -15.208 -21.737 1.00 97.17 C \\\\nATOM 2506 N ASN A 320 12.057 -13.181 -19.638 1.00 96.50 N \\\\nATOM 2507 CA ASN A 320 13.054 -12.117 -19.802 1.00 96.50 C \\\\nATOM 2508 C ASN A 320 13.523 -11.529 -18.459 1.00 96.50 C \\\\nATOM 2509 CB ASN A 320 12.464 -11.029 -20.705 1.00 96.50 C \\\\nATOM 2510 O ASN A 320 14.186 -10.488 -18.414 1.00 96.50 O \\\\nATOM 2511 CG ASN A 320 12.086 -11.526 -22.084 1.00 96.50 C \\\\nATOM 2512 ND2 ASN A 320 11.033 -10.985 -22.645 1.00 96.50 N \\\\nATOM 2513 OD1 ASN A 320 12.723 -12.384 -22.669 1.00 96.50 O \\\\nATOM 2514 N ARG A 321 13.147 -12.154 -17.338 1.00 97.58 N \\\\nATOM 2515 CA ARG A 321 13.455 -11.652 -16.001 1.00 97.58 C \\\\nATOM 2516 C ARG A 321 14.955 -11.720 -15.729 1.00 97.58 C \\\\nATOM 2517 CB ARG A 321 12.655 -12.456 -14.978 1.00 97.58 C \\\\nATOM 2518 O ARG A 321 15.547 -12.792 -15.714 1.00 97.58 O \\\\nATOM 2519 CG ARG A 321 12.835 -11.900 -13.562 1.00 97.58 C \\\\nATOM 2520 CD ARG A 321 11.934 -12.637 -12.575 1.00 97.58 C \\\\nATOM 2521 NE ARG A 321 10.512 -12.373 -12.857 1.00 97.58 N \\\\nATOM 2522 NH1 ARG A 321 9.606 -14.398 -12.205 1.00 97.58 N \\\\nATOM 2523 NH2 ARG A 321 8.307 -12.773 -12.966 1.00 97.58 N \\\\nATOM 2524 CZ ARG A 321 9.494 -13.189 -12.681 1.00 97.58 C \\\\nATOM 2525 N ASN A 322 15.557 -10.570 -15.437 1.00 97.73 N \\\\nATOM 2526 CA ASN A 322 16.963 -10.493 -15.040 1.00 97.73 C \\\\nATOM 2527 C ASN A 322 17.152 -10.588 -13.511 1.00 97.73 C \\\\nATOM 2528 CB ASN A 322 17.599 -9.249 -15.686 1.00 97.73 C \\\\nATOM 2529 O ASN A 322 16.209 -10.436 -12.729 1.00 97.73 O \\\\nATOM 2530 CG ASN A 322 17.151 -7.924 -15.094 1.00 97.73 C \\\\nATOM 2531 ND2 ASN A 322 16.987 -6.916 -15.913 1.00 97.73 N \\\\nATOM 2532 OD1 ASN A 322 16.995 -7.756 -13.892 1.00 97.73 O \\\\nATOM 2533 N ALA A 323 18.404 -10.758 -13.075 1.00 98.07 N \\\\nATOM 2534 CA ALA A 323 18.758 -10.909 -11.661 1.00 98.07 C \\\\nATOM 2535 C ALA A 323 18.328 -9.721 -10.772 1.00 98.07 C \\\\nATOM 2536 CB ALA A 323 20.276 -11.121 -11.582 1.00 98.07 C \\\\nATOM 2537 O ALA A 323 17.970 -9.910 -9.609 1.00 98.07 O \\\\nATOM 2538 N THR A 324 18.318 -8.489 -11.304 1.00 97.78 N \\\\nATOM 2539 CA THR A 324 17.886 -7.300 -10.543 1.00 97.78 C \\\\nATOM 2540 C THR A 324 16.382 -7.333 -10.272 1.00 97.78 C \\\\nATOM 2541 CB THR A 324 18.247 -5.996 -11.274 1.00 97.78 C \\\\nATOM 2542 O THR A 324 15.947 -7.012 -9.162 1.00 97.78 O \\\\nATOM 2543 CG2 THR A 324 17.804 -4.742 -10.517 1.00 97.78 C \\\\nATOM 2544 OG1 THR A 324 19.643 -5.883 -11.404 1.00 97.78 O \\\\nATOM 2545 N VAL A 325 15.585 -7.737 -11.264 1.00 98.29 N \\\\nATOM 2546 CA VAL A 325 14.136 -7.931 -11.116 1.00 98.29 C \\\\nATOM 2547 C VAL A 325 13.861 -9.056 -10.125 1.00 98.29 C \\\\nATOM 2548 CB VAL A 325 13.481 -8.218 -12.478 1.00 98.29 C \\\\nATOM 2549 O VAL A 325 13.096 -8.871 -9.184 1.00 98.29 O \\\\nATOM 2550 CG1 VAL A 325 11.986 -8.490 -12.319 1.00 98.29 C \\\\nATOM 2551 CG2 VAL A 325 13.630 -7.049 -13.462 1.00 98.29 C \\\\nATOM 2552 N GLU A 326 14.549 -10.189 -10.255 1.00 97.74 N \\\\nATOM 2553 CA GLU A 326 14.381 -11.326 -9.349 1.00 97.74 C \\\\nATOM 2554 C GLU A 326 14.725 -10.975 -7.890 1.00 97.74 C \\\\nATOM 2555 CB GLU A 326 15.262 -12.471 -9.852 1.00 97.74 C \\\\nATOM 2556 O GLU A 326 14.016 -11.359 -6.960 1.00 97.74 O \\\\nATOM 2557 CG GLU A 326 14.721 -13.828 -9.395 1.00 97.74 C \\\\nATOM 2558 CD GLU A 326 15.759 -14.933 -9.594 1.00 97.74 C \\\\nATOM 2559 OE1 GLU A 326 15.776 -15.832 -8.727 1.00 97.74 O \\\\nATOM 2560 OE2 GLU A 326 16.610 -14.789 -10.490 1.00 97.74 O \\\\nATOM 2561 N MET A 327 15.794 -10.209 -7.659 1.00 97.59 N \\\\nATOM 2562 CA MET A 327 16.147 -9.710 -6.327 1.00 97.59 C \\\\nATOM 2563 C MET A 327 15.103 -8.722 -5.792 1.00 97.59 C \\\\nATOM 2564 CB MET A 327 17.539 -9.070 -6.389 1.00 97.59 C \\\\nATOM 2565 O MET A 327 14.763 -8.762 -4.611 1.00 97.59 O \\\\nATOM 2566 CG MET A 327 18.035 -8.631 -5.006 1.00 97.59 C \\\\nATOM 2567 SD MET A 327 19.672 -7.856 -5.020 1.00 97.59 S \\\\nATOM 2568 CE MET A 327 20.725 -9.310 -5.290 1.00 97.59 C \\\\nATOM 2569 N THR A 328 14.567 -7.855 -6.653 1.00 98.24 N \\\\nATOM 2570 CA THR A 328 13.542 -6.872 -6.271 1.00 98.24 C \\\\nATOM 2571 C THR A 328 12.232 -7.556 -5.877 1.00 98.24 C \\\\nATOM 2572 CB THR A 328 13.318 -5.853 -7.398 1.00 98.24 C \\\\nATOM 2573 O THR A 328 11.670 -7.224 -4.836 1.00 98.24 O \\\\nATOM 2574 CG2 THR A 328 12.306 -4.781 -7.010 1.00 98.24 C \\\\nATOM 2575 OG1 THR A 328 14.542 -5.197 -7.673 1.00 98.24 O \\\\nATOM 2576 N ARG A 329 11.798 -8.577 -6.628 1.00 98.35 N \\\\nATOM 2577 CA ARG A 329 10.590 -9.370 -6.335 1.00 98.35 C \\\\nATOM 2578 C ARG A 329 10.609 -9.990 -4.937 1.00 98.35 C \\\\nATOM 2579 CB ARG A 329 10.412 -10.460 -7.402 1.00 98.35 C \\\\nATOM 2580 O ARG A 329 9.590 -9.963 -4.254 1.00 98.35 O \\\\nATOM 2581 CG ARG A 329 9.955 -9.872 -8.744 1.00 98.35 C \\\\nATOM 2582 CD ARG A 329 10.008 -10.903 -9.872 1.00 98.35 C \\\\nATOM 2583 NE ARG A 329 9.130 -12.058 -9.617 1.00 98.35 N \\\\nATOM 2584 NH1 ARG A 329 7.139 -11.118 -10.318 1.00 98.35 N \\\\nATOM 2585 NH2 ARG A 329 7.166 -13.166 -9.480 1.00 98.35 N \\\\nATOM 2586 CZ ARG A 329 7.825 -12.099 -9.806 1.00 98.35 C \\\\nATOM 2587 N ARG A 330 11.773 -10.465 -4.472 1.00 97.77 N \\\\nATOM 2588 CA ARG A 330 11.949 -11.017 -3.111 1.00 97.77 C \\\\nATOM 2589 C ARG A 330 11.653 -10.000 -2.003 1.00 97.77 C \\\\nATOM 2590 CB ARG A 330 13.377 -11.557 -2.929 1.00 97.77 C \\\\nATOM 2591 O ARG A 330 11.192 -10.388 -0.938 1.00 97.77 O \\\\nATOM 2592 CG ARG A 330 13.676 -12.800 -3.778 1.00 97.77 C \\\\nATOM 2593 CD ARG A 330 15.146 -13.199 -3.598 1.00 97.77 C \\\\nATOM 2594 NE ARG A 330 15.505 -14.389 -4.391 1.00 97.77 N \\\\nATOM 2595 NH1 ARG A 330 16.166 -13.356 -6.344 1.00 97.77 N \\\\nATOM 2596 NH2 ARG A 330 16.360 -15.551 -6.138 1.00 97.77 N \\\\nATOM 2597 CZ ARG A 330 16.011 -14.419 -5.612 1.00 97.77 C \\\\nATOM 2598 N HIS A 331 11.891 -8.714 -2.261 1.00 97.91 N \\\\nATOM 2599 CA HIS A 331 11.701 -7.631 -1.292 1.00 97.91 C \\\\nATOM 2600 C HIS A 331 10.309 -6.993 -1.356 1.00 97.91 C \\\\nATOM 2601 CB HIS A 331 12.799 -6.580 -1.485 1.00 97.91 C \\\\nATOM 2602 O HIS A 331 9.998 -6.134 -0.536 1.00 97.91 O \\\\nATOM 2603 CG HIS A 331 14.171 -7.075 -1.124 1.00 97.91 C \\\\nATOM 2604 CD2 HIS A 331 14.804 -6.915 0.079 1.00 97.91 C \\\\nATOM 2605 ND1 HIS A 331 15.028 -7.762 -1.952 1.00 97.91 N \\\\nATOM 2606 CE1 HIS A 331 16.153 -8.011 -1.265 1.00 97.91 C \\\\nATOM 2607 NE2 HIS A 331 16.067 -7.506 -0.028 1.00 97.91 N \\\\nATOM 2608 N ILE A 332 9.444 -7.410 -2.291 1.00 98.33 N \\\\nATOM 2609 CA ILE A 332 8.044 -6.968 -2.289 1.00 98.33 C \\\\nATOM 2610 C ILE A 332 7.382 -7.439 -0.989 1.00 98.33 C \\\\nATOM 2611 CB ILE A 332 7.289 -7.454 -3.548 1.00 98.33 C \\\\nATOM 2612 O ILE A 332 6.767 -6.633 -0.291 1.00 98.33 O \\\\nATOM 2613 CG1 ILE A 332 7.951 -6.868 -4.816 1.00 98.33 C \\\\nATOM 2614 CG2 ILE A 332 5.803 -7.051 -3.477 1.00 98.33 C \\\\nATOM 2615 CD1 ILE A 332 7.322 -7.321 -6.138 1.00 98.33 C \\\\nATOM 2616 N GLY A 333 7.564 -8.710 -0.613 1.00 96.97 N \\\\nATOM 2617 CA GLY A 333 7.011 -9.267 0.622 1.00 96.97 C \\\\nATOM 2618 C GLY A 333 5.499 -9.059 0.688 1.00 96.97 C \\\\nATOM 2619 O GLY A 333 4.781 -9.431 -0.234 1.00 96.97 O \\\\nATOM 2620 N ARG A 334 5.014 -8.404 1.747 1.00 96.99 N \\\\nATOM 2621 CA ARG A 334 3.590 -8.052 1.914 1.00 96.99 C \\\\nATOM 2622 C ARG A 334 3.105 -6.923 0.990 1.00 96.99 C \\\\nATOM 2623 CB ARG A 334 3.332 -7.682 3.376 1.00 96.99 C \\\\nATOM 2624 O ARG A 334 1.907 -6.669 0.949 1.00 96.99 O \\\\nATOM 2625 CG ARG A 334 3.610 -8.820 4.371 1.00 96.99 C \\\\nATOM 2626 CD ARG A 334 3.509 -8.312 5.813 1.00 96.99 C \\\\nATOM 2627 NE ARG A 334 2.156 -7.801 6.116 1.00 96.99 N \\\\nATOM 2628 NH1 ARG A 334 2.778 -6.270 7.713 1.00 96.99 N \\\\nATOM 2629 NH2 ARG A 334 0.650 -6.379 7.050 1.00 96.99 N \\\\nATOM 2630 CZ ARG A 334 1.871 -6.829 6.963 1.00 96.99 C \\\\nATOM 2631 N GLY A 335 4.019 -6.256 0.284 1.00 97.95 N \\\\nATOM 2632 CA GLY A 335 3.738 -5.303 -0.786 1.00 97.95 C \\\\nATOM 2633 C GLY A 335 2.956 -4.063 -0.355 1.00 97.95 C \\\\nATOM 2634 O GLY A 335 3.332 -3.387 0.604 1.00 97.95 O \\\\nATOM 2635 N VAL A 336 1.898 -3.735 -1.094 1.00 98.47 N \\\\nATOM 2636 CA VAL A 336 1.054 -2.552 -0.872 1.00 98.47 C \\\\nATOM 2637 C VAL A 336 -0.393 -2.973 -0.664 1.00 98.47 C \\\\nATOM 2638 CB VAL A 336 1.204 -1.522 -2.012 1.00 98.47 C \\\\nATOM 2639 O VAL A 336 -0.916 -3.807 -1.401 1.00 98.47 O \\\\nATOM 2640 CG1 VAL A 336 0.789 -2.047 -3.392 1.00 98.47 C \\\\nATOM 2641 CG2 VAL A 336 0.412 -0.237 -1.741 1.00 98.47 C \\\\nATOM 2642 N ARG A 337 -1.062 -2.375 0.322 1.00 97.58 N \\\\nATOM 2643 CA ARG A 337 -2.518 -2.443 0.435 1.00 97.58 C \\\\nATOM 2644 C ARG A 337 -3.132 -1.201 -0.182 1.00 97.58 C \\\\nATOM 2645 CB ARG A 337 -2.931 -2.656 1.887 1.00 97.58 C \\\\nATOM 2646 O ARG A 337 -2.751 -0.086 0.167 1.00 97.58 O \\\\nATOM 2647 CG ARG A 337 -4.458 -2.695 2.038 1.00 97.58 C \\\\nATOM 2648 CD ARG A 337 -4.849 -2.850 3.499 1.00 97.58 C \\\\nATOM 2649 NE ARG A 337 -4.440 -4.165 4.015 1.00 97.58 N \\\\nATOM 2650 NH1 ARG A 337 -4.005 -3.476 6.154 1.00 97.58 N \\\\nATOM 2651 NH2 ARG A 337 -4.062 -5.673 5.649 1.00 97.58 N \\\\nATOM 2652 CZ ARG A 337 -4.166 -4.427 5.272 1.00 97.58 C \\\\nATOM 2653 N LEU A 338 -4.098 -1.415 -1.063 1.00 97.59 N \\\\nATOM 2654 CA LEU A 338 -4.912 -0.367 -1.655 1.00 97.59 C \\\\nATOM 2655 C LEU A 338 -6.320 -0.481 -1.098 1.00 97.59 C \\\\nATOM 2656 CB LEU A 338 -4.897 -0.468 -3.187 1.00 97.59 C \\\\nATOM 2657 O LEU A 338 -6.879 -1.579 -1.059 1.00 97.59 O \\\\nATOM 2658 CG LEU A 338 -3.497 -0.423 -3.817 1.00 97.59 C \\\\nATOM 2659 CD1 LEU A 338 -3.606 -0.648 -5.321 1.00 97.59 C \\\\nATOM 2660 CD2 LEU A 338 -2.817 0.921 -3.570 1.00 97.59 C \\\\nATOM 2661 N TYR A 339 -6.886 0.635 -0.657 1.00 94.29 N \\\\nATOM 2662 CA TYR A 339 -8.265 0.657 -0.192 1.00 94.29 C \\\\nATOM 2663 C TYR A 339 -9.008 1.896 -0.686 1.00 94.29 C \\\\nATOM 2664 CB TYR A 339 -8.335 0.456 1.329 1.00 94.29 C \\\\nATOM 2665 O TYR A 339 -8.458 2.998 -0.687 1.00 94.29 O \\\\nATOM 2666 CG TYR A 339 -7.543 1.443 2.169 1.00 94.29 C \\\\nATOM 2667 CD1 TYR A 339 -6.210 1.165 2.529 1.00 94.29 C \\\\nATOM 2668 CD2 TYR A 339 -8.145 2.635 2.605 1.00 94.29 C \\\\nATOM 2669 CE1 TYR A 339 -5.487 2.074 3.325 1.00 94.29 C \\\\nATOM 2670 CE2 TYR A 339 -7.443 3.529 3.435 1.00 94.29 C \\\\nATOM 2671 OH TYR A 339 -5.372 4.184 4.461 1.00 94.29 O \\\\nATOM 2672 CZ TYR A 339 -6.099 3.260 3.778 1.00 94.29 C \\\\nATOM 2673 N TYR A 340 -10.252 1.677 -1.109 1.00 94.08 N \\\\nATOM 2674 CA TYR A 340 -11.198 2.666 -1.603 1.00 94.08 C \\\\nATOM 2675 C TYR A 340 -12.298 2.883 -0.566 1.00 94.08 C \\\\nATOM 2676 CB TYR A 340 -11.787 2.203 -2.940 1.00 94.08 C \\\\nATOM 2677 O TYR A 340 -13.059 1.967 -0.251 1.00 94.08 O \\\\nATOM 2678 CG TYR A 340 -12.829 3.157 -3.495 1.00 94.08 C \\\\nATOM 2679 CD1 TYR A 340 -14.131 2.706 -3.792 1.00 94.08 C \\\\nATOM 2680 CD2 TYR A 340 -12.493 4.507 -3.719 1.00 94.08 C \\\\nATOM 2681 CE1 TYR A 340 -15.084 3.595 -4.329 1.00 94.08 C \\\\nATOM 2682 CE2 TYR A 340 -13.440 5.394 -4.262 1.00 94.08 C \\\\nATOM 2683 OH TYR A 340 -15.648 5.811 -5.089 1.00 94.08 O \\\\nATOM 2684 CZ TYR A 340 -14.740 4.941 -4.572 1.00 94.08 C \\\\nATOM 2685 N ILE A 341 -12.338 4.078 0.021 1.00 89.81 N \\\\nATOM 2686 CA ILE A 341 -13.234 4.410 1.131 1.00 89.81 C \\\\nATOM 2687 C ILE A 341 -13.700 5.849 0.976 1.00 89.81 C \\\\nATOM 2688 CB ILE A 341 -12.529 4.199 2.489 1.00 89.81 C \\\\nATOM 2689 O ILE A 341 -12.882 6.758 0.866 1.00 89.81 O \\\\nATOM 2690 CG1 ILE A 341 -12.080 2.726 2.624 1.00 89.81 C \\\\nATOM 2691 CG2 ILE A 341 -13.460 4.596 3.652 1.00 89.81 C \\\\nATOM 2692 CD1 ILE A 341 -11.307 2.440 3.893 1.00 89.81 C \\\\nATOM 2693 N GLY A 342 -15.016 6.063 0.993 1.00 86.14 N \\\\nATOM 2694 CA GLY A 342 -15.597 7.405 0.992 1.00 86.14 C \\\\nATOM 2695 C GLY A 342 -15.259 8.241 -0.249 1.00 86.14 C \\\\nATOM 2696 O GLY A 342 -15.158 9.458 -0.142 1.00 86.14 O \\\\nATOM 2697 N GLY A 343 -15.028 7.616 -1.409 1.00 91.06 N \\\\nATOM 2698 CA GLY A 343 -14.581 8.324 -2.616 1.00 91.06 C \\\\nATOM 2699 C GLY A 343 -13.084 8.656 -2.634 1.00 91.06 C \\\\nATOM 2700 O GLY A 343 -12.636 9.430 -3.477 1.00 91.06 O \\\\nATOM 2701 N GLU A 344 -12.297 8.093 -1.718 1.00 95.31 N \\\\nATOM 2702 CA GLU A 344 -10.852 8.298 -1.624 1.00 95.31 C \\\\nATOM 2703 C GLU A 344 -10.106 6.972 -1.770 1.00 95.31 C \\\\nATOM 2704 CB GLU A 344 -10.482 8.970 -0.295 1.00 95.31 C \\\\nATOM 2705 O GLU A 344 -10.546 5.940 -1.260 1.00 95.31 O \\\\nATOM 2706 CG GLU A 344 -11.302 10.232 -0.002 1.00 95.31 C \\\\nATOM 2707 CD GLU A 344 -10.703 11.044 1.148 1.00 95.31 C \\\\nATOM 2708 OE1 GLU A 344 -10.492 12.263 0.951 1.00 95.31 O \\\\nATOM 2709 OE2 GLU A 344 -10.289 10.495 2.196 1.00 95.31 O \\\\nATOM 2710 N VAL A 345 -8.951 6.998 -2.437 1.00 97.02 N \\\\nATOM 2711 CA VAL A 345 -8.064 5.834 -2.562 1.00 97.02 C \\\\nATOM 2712 C VAL A 345 -6.793 6.093 -1.773 1.00 97.02 C \\\\nATOM 2713 CB VAL A 345 -7.734 5.471 -4.021 1.00 97.02 C \\\\nATOM 2714 O VAL A 345 -6.159 7.145 -1.907 1.00 97.02 O \\\\nATOM 2715 CG1 VAL A 345 -6.968 4.143 -4.103 1.00 97.02 C \\\\nATOM 2716 CG2 VAL A 345 -8.986 5.315 -4.892 1.00 97.02 C \\\\nATOM 2717 N PHE A 346 -6.380 5.106 -0.989 1.00 97.07 N \\\\nATOM 2718 CA PHE A 346 -5.151 5.148 -0.209 1.00 97.07 C \\\\nATOM 2719 C PHE A 346 -4.224 3.991 -0.574 1.00 97.07 C \\\\nATOM 2720 CB PHE A 346 -5.493 5.078 1.271 1.00 97.07 C \\\\nATOM 2721 O PHE A 346 -4.683 2.895 -0.893 1.00 97.07 O \\\\nATOM 2722 CG PHE A 346 -6.297 6.235 1.835 1.00 97.07 C \\\\nATOM 2723 CD1 PHE A 346 -5.655 7.239 2.584 1.00 97.07 C \\\\nATOM 2724 CD2 PHE A 346 -7.695 6.276 1.669 1.00 97.07 C \\\\nATOM 2725 CE1 PHE A 346 -6.405 8.281 3.159 1.00 97.07 C \\\\nATOM 2726 CE2 PHE A 346 -8.443 7.312 2.250 1.00 97.07 C \\\\nATOM 2727 CZ PHE A 346 -7.800 8.318 2.989 1.00 97.07 C \\\\nATOM 2728 N ALA A 347 -2.919 4.234 -0.463 1.00 97.96 N \\\\nATOM 2729 CA ALA A 347 -1.883 3.211 -0.516 1.00 97.96 C \\\\nATOM 2730 C ALA A 347 -1.181 3.105 0.840 1.00 97.96 C \\\\nATOM 2731 CB ALA A 347 -0.893 3.540 -1.640 1.00 97.96 C \\\\nATOM 2732 O ALA A 347 -0.631 4.091 1.324 1.00 97.96 O \\\\nATOM 2733 N GLU A 348 -1.175 1.913 1.434 1.00 97.60 N \\\\nATOM 2734 CA GLU A 348 -0.460 1.568 2.668 1.00 97.60 C \\\\nATOM 2735 C GLU A 348 0.707 0.628 2.335 1.00 97.60 C \\\\nATOM 2736 CB GLU A 348 -1.450 0.952 3.679 1.00 97.60 C \\\\nATOM 2737 O GLU A 348 0.514 -0.455 1.775 1.00 97.60 O \\\\nATOM 2738 CG GLU A 348 -0.813 0.537 5.019 1.00 97.60 C \\\\nATOM 2739 CD GLU A 348 -1.741 -0.274 5.959 1.00 97.60 C \\\\nATOM 2740 OE1 GLU A 348 -1.431 -0.329 7.170 1.00 97.60 O \\\\nATOM 2741 OE2 GLU A 348 -2.691 -0.964 5.499 1.00 97.60 O \\\\nATOM 2742 N CYS A 349 1.932 1.025 2.684 1.00 97.68 N \\\\nATOM 2743 CA CYS A 349 3.120 0.208 2.464 1.00 97.68 C \\\\nATOM 2744 C CYS A 349 3.221 -0.877 3.542 1.00 97.68 C \\\\nATOM 2745 CB CYS A 349 4.354 1.110 2.436 1.00 97.68 C \\\\nATOM 2746 O CYS A 349 3.591 -0.606 4.685 1.00 97.68 O \\\\nATOM 2747 SG CYS A 349 5.812 0.141 1.956 1.00 97.68 S \\\\nATOM 2748 N LEU A 350 2.915 -2.121 3.168 1.00 97.08 N \\\\nATOM 2749 CA LEU A 350 3.031 -3.288 4.046 1.00 97.08 C \\\\nATOM 2750 C LEU A 350 4.384 -3.999 3.924 1.00 97.08 C \\\\nATOM 2751 CB LEU A 350 1.897 -4.273 3.731 1.00 97.08 C \\\\nATOM 2752 O LEU A 350 4.718 -4.808 4.790 1.00 97.08 O \\\\nATOM 2753 CG LEU A 350 0.470 -3.734 3.912 1.00 97.08 C \\\\nATOM 2754 CD1 LEU A 350 -0.500 -4.899 3.700 1.00 97.08 C \\\\nATOM 2755 CD2 LEU A 350 0.237 -3.171 5.314 1.00 97.08 C \\\\nATOM 2756 N SER A 351 5.112 -3.742 2.837 1.00 97.55 N \\\\nATOM 2757 CA SER A 351 6.471 -4.219 2.599 1.00 97.55 C \\\\nATOM 2758 C SER A 351 7.459 -3.616 3.600 1.00 97.55 C \\\\nATOM 2759 CB SER A 351 6.889 -3.842 1.174 1.00 97.55 C \\\\nATOM 2760 O SER A 351 7.312 -2.464 4.008 1.00 97.55 O \\\\nATOM 2761 OG SER A 351 8.183 -4.338 0.888 1.00 97.55 O \\\\nATOM 2762 N ASP A 352 8.506 -4.376 3.928 1.00 97.73 N \\\\nATOM 2763 CA ASP A 352 9.672 -3.889 4.679 1.00 97.73 C \\\\nATOM 2764 C ASP A 352 10.552 -2.948 3.829 1.00 97.73 C \\\\nATOM 2765 CB ASP A 352 10.497 -5.086 5.177 1.00 97.73 C \\\\nATOM 2766 O ASP A 352 11.463 -2.295 4.335 1.00 97.73 O \\\\nATOM 2767 CG ASP A 352 9.687 -6.060 6.040 1.00 97.73 C \\\\nATOM 2768 OD1 ASP A 352 8.900 -5.590 6.891 1.00 97.73 O \\\\nATOM 2769 OD2 ASP A 352 9.822 -7.280 5.800 1.00 97.73 O \\\\nATOM 2770 N SER A 353 10.281 -2.861 2.523 1.00 97.87 N \\\\nATOM 2771 CA SER A 353 10.881 -1.908 1.590 1.00 97.87 C \\\\nATOM 2772 C SER A 353 9.872 -0.838 1.176 1.00 97.87 C \\\\nATOM 2773 CB SER A 353 11.387 -2.646 0.355 1.00 97.87 C \\\\nATOM 2774 O SER A 353 8.687 -1.110 1.029 1.00 97.87 O \\\\nATOM 2775 OG SER A 353 12.472 -3.474 0.711 1.00 97.87 O \\\\nATOM 2776 N ALA A 354 10.346 0.386 0.938 1.00 98.19 N \\\\nATOM 2777 CA ALA A 354 9.480 1.481 0.503 1.00 98.19 C \\\\nATOM 2778 C ALA A 354 8.854 1.226 -0.880 1.00 98.19 C \\\\nATOM 2779 CB ALA A 354 10.281 2.789 0.517 1.00 98.19 C \\\\nATOM 2780 O ALA A 354 9.454 0.578 -1.746 1.00 98.19 O \\\\nATOM 2781 N ILE A 355 7.686 1.826 -1.100 1.00 98.61 N \\\\nATOM 2782 CA ILE A 355 7.050 1.953 -2.416 1.00 98.61 C \\\\nATOM 2783 C ILE A 355 7.110 3.408 -2.884 1.00 98.61 C \\\\nATOM 2784 CB ILE A 355 5.617 1.375 -2.426 1.00 98.61 C \\\\nATOM 2785 O ILE A 355 7.277 4.332 -2.086 1.00 98.61 O \\\\nATOM 2786 CG1 ILE A 355 4.688 2.175 -1.494 1.00 98.61 C \\\\nATOM 2787 CG2 ILE A 355 5.653 -0.123 -2.075 1.00 98.61 C \\\\nATOM 2788 CD1 ILE A 355 3.241 1.685 -1.442 1.00 98.61 C \\\\nATOM 2789 N PHE A 356 6.994 3.616 -4.188 1.00 98.53 N \\\\nATOM 2790 CA PHE A 356 7.125 4.925 -4.823 1.00 98.53 C \\\\nATOM 2791 C PHE A 356 5.921 5.140 -5.721 1.00 98.53 C \\\\nATOM 2792 CB PHE A 356 8.440 4.970 -5.608 1.00 98.53 C \\\\nATOM 2793 O PHE A 356 5.652 4.287 -6.556 1.00 98.53 O \\\\nATOM 2794 CG PHE A 356 9.661 4.735 -4.752 1.00 98.53 C \\\\nATOM 2795 CD1 PHE A 356 10.376 5.816 -4.206 1.00 98.53 C \\\\nATOM 2796 CD2 PHE A 356 10.061 3.416 -4.470 1.00 98.53 C \\\\nATOM 2797 CE1 PHE A 356 11.488 5.562 -3.384 1.00 98.53 C \\\\nATOM 2798 CE2 PHE A 356 11.152 3.175 -3.623 1.00 98.53 C \\\\nATOM 2799 CZ PHE A 356 11.881 4.248 -3.096 1.00 98.53 C \\\\nATOM 2800 N VAL A 357 5.184 6.229 -5.533 1.00 98.21 N \\\\nATOM 2801 CA VAL A 357 3.879 6.458 -6.159 1.00 98.21 C \\\\nATOM 2802 C VAL A 357 3.912 7.739 -6.975 1.00 98.21 C \\\\nATOM 2803 CB VAL A 357 2.761 6.519 -5.101 1.00 98.21 C \\\\nATOM 2804 O VAL A 357 4.269 8.792 -6.458 1.00 98.21 O \\\\nATOM 2805 CG1 VAL A 357 1.389 6.733 -5.755 1.00 98.21 C \\\\nATOM 2806 CG2 VAL A 357 2.726 5.232 -4.262 1.00 98.21 C \\\\nATOM 2807 N GLN A 358 3.482 7.661 -8.228 1.00 98.17 N \\\\nATOM 2808 CA GLN A 358 3.169 8.813 -9.064 1.00 98.17 C \\\\nATOM 2809 C GLN A 358 1.657 8.841 -9.264 1.00 98.17 C \\\\nATOM 2810 CB GLN A 358 3.941 8.699 -10.381 1.00 98.17 C \\\\nATOM 2811 O GLN A 358 1.110 8.033 -10.017 1.00 98.17 O \\\\nATOM 2812 CG GLN A 358 3.722 9.881 -11.334 1.00 98.17 C \\\\nATOM 2813 CD GLN A 358 4.458 9.662 -12.654 1.00 98.17 C \\\\nATOM 2814 NE2 GLN A 358 5.532 10.379 -12.912 1.00 98.17 N \\\\nATOM 2815 OE1 GLN A 358 4.105 8.810 -13.458 1.00 98.17 O \\\\nATOM 2816 N SER A 359 0.989 9.755 -8.561 1.00 97.96 N \\\\nATOM 2817 CA SER A 359 -0.434 10.039 -8.743 1.00 97.96 C \\\\nATOM 2818 C SER A 359 -0.601 11.513 -9.107 1.00 97.96 C \\\\nATOM 2819 CB SER A 359 -1.239 9.712 -7.487 1.00 97.96 C \\\\nATOM 2820 O SER A 359 -0.374 12.367 -8.244 1.00 97.96 O \\\\nATOM 2821 OG SER A 359 -2.534 10.252 -7.659 1.00 97.96 O \\\\nATOM 2822 N PRO A 360 -1.021 11.832 -10.342 1.00 97.02 N \\\\nATOM 2823 CA PRO A 360 -1.266 13.212 -10.746 1.00 97.02 C \\\\nATOM 2824 C PRO A 360 -2.301 13.928 -9.861 1.00 97.02 C \\\\nATOM 2825 CB PRO A 360 -1.701 13.112 -12.207 1.00 97.02 C \\\\nATOM 2826 O PRO A 360 -2.092 15.082 -9.499 1.00 97.02 O \\\\nATOM 2827 CG PRO A 360 -0.983 11.862 -12.707 1.00 97.02 C \\\\nATOM 2828 CD PRO A 360 -1.102 10.942 -11.498 1.00 97.02 C \\\\nATOM 2829 N ASN A 361 -3.351 13.228 -9.408 1.00 97.36 N \\\\nATOM 2830 CA ASN A 361 -4.341 13.769 -8.464 1.00 97.36 C \\\\nATOM 2831 C ASN A 361 -3.713 14.156 -7.117 1.00 97.36 C \\\\nATOM 2832 CB ASN A 361 -5.472 12.738 -8.310 1.00 97.36 C \\\\nATOM 2833 O ASN A 361 -3.924 15.261 -6.622 1.00 97.36 O \\\\nATOM 2834 CG ASN A 361 -6.573 13.205 -7.372 1.00 97.36 C \\\\nATOM 2835 ND2 ASN A 361 -7.574 13.894 -7.865 1.00 97.36 N \\\\nATOM 2836 OD1 ASN A 361 -6.548 12.926 -6.183 1.00 97.36 O \\\\nATOM 2837 N CYS A 362 -2.876 13.280 -6.556 1.00 96.14 N \\\\nATOM 2838 CA CYS A 362 -2.138 13.572 -5.328 1.00 96.14 C \\\\nATOM 2839 C CYS A 362 -1.158 14.740 -5.520 1.00 96.14 C \\\\nATOM 2840 CB CYS A 362 -1.401 12.295 -4.912 1.00 96.14 C \\\\nATOM 2841 O CYS A 362 -1.072 15.621 -4.668 1.00 96.14 O \\\\nATOM 2842 SG CYS A 362 -0.540 12.518 -3.334 1.00 96.14 S \\\\nATOM 2843 N ASN A 363 -0.430 14.758 -6.637 1.00 96.49 N \\\\nATOM 2844 CA ASN A 363 0.555 15.793 -6.934 1.00 96.49 C \\\\nATOM 2845 C ASN A 363 -0.107 17.169 -7.060 1.00 96.49 C \\\\nATOM 2846 CB ASN A 363 1.332 15.387 -8.199 1.00 96.49 C \\\\nATOM 2847 O ASN A 363 0.365 18.123 -6.448 1.00 96.49 O \\\\nATOM 2848 CG ASN A 363 2.246 14.195 -7.964 1.00 96.49 C \\\\nATOM 2849 ND2 ASN A 363 2.709 13.537 -8.998 1.00 96.49 N \\\\nATOM 2850 OD1 ASN A 363 2.590 13.845 -6.847 1.00 96.49 O \\\\nATOM 2851 N GLN A 364 -1.248 17.251 -7.749 1.00 95.57 N \\\\nATOM 2852 CA GLN A 364 -2.022 18.483 -7.863 1.00 95.57 C \\\\nATOM 2853 C GLN A 364 -2.529 18.980 -6.503 1.00 95.57 C \\\\nATOM 2854 CB GLN A 364 -3.164 18.253 -8.857 1.00 95.57 C \\\\nATOM 2855 O GLN A 364 -2.400 20.168 -6.215 1.00 95.57 O \\\\nATOM 2856 CG GLN A 364 -3.989 19.528 -9.096 1.00 95.57 C \\\\nATOM 2857 CD GLN A 364 -4.957 19.385 -10.265 1.00 95.57 C \\\\nATOM 2858 NE2 GLN A 364 -5.916 20.272 -10.402 1.00 95.57 N \\\\nATOM 2859 OE1 GLN A 364 -4.870 18.483 -11.078 1.00 95.57 O \\\\nATOM 2860 N ARG A 365 -3.030 18.089 -5.632 1.00 95.41 N \\\\nATOM 2861 CA ARG A 365 -3.483 18.449 -4.273 1.00 95.41 C \\\\nATOM 2862 C ARG A 365 -2.396 19.155 -3.458 1.00 95.41 C \\\\nATOM 2863 CB ARG A 365 -3.955 17.182 -3.540 1.00 95.41 C \\\\nATOM 2864 O ARG A 365 -2.692 20.091 -2.721 1.00 95.41 O \\\\nATOM 2865 CG ARG A 365 -4.554 17.483 -2.151 1.00 95.41 C \\\\nATOM 2866 CD ARG A 365 -4.732 16.213 -1.315 1.00 95.41 C \\\\nATOM 2867 NE ARG A 365 -5.657 15.286 -1.972 1.00 95.41 N \\\\nATOM 2868 NH1 ARG A 365 -4.525 13.324 -1.744 1.00 95.41 N \\\\nATOM 2869 NH2 ARG A 365 -6.301 13.471 -3.120 1.00 95.41 N \\\\nATOM 2870 CZ ARG A 365 -5.495 14.021 -2.269 1.00 95.41 C \\\\nATOM 2871 N TYR A 366 -1.151 18.699 -3.571 1.00 94.64 N \\\\nATOM 2872 CA TYR A 366 -0.016 19.262 -2.833 1.00 94.64 C \\\\nATOM 2873 C TYR A 366 0.746 20.354 -3.601 1.00 94.64 C \\\\nATOM 2874 CB TYR A 366 0.897 18.124 -2.357 1.00 94.64 C \\\\nATOM 2875 O TYR A 366 1.752 20.850 -3.098 1.00 94.64 O \\\\nATOM 2876 CG TYR A 366 0.253 17.198 -1.339 1.00 94.64 C \\\\nATOM 2877 CD1 TYR A 366 -0.097 17.689 -0.066 1.00 94.64 C \\\\nATOM 2878 CD2 TYR A 366 0.010 15.849 -1.656 1.00 94.64 C \\\\nATOM 2879 CE1 TYR A 366 -0.699 16.839 0.883 1.00 94.64 C \\\\nATOM 2880 CE2 TYR A 366 -0.598 14.996 -0.716 1.00 94.64 C \\\\nATOM 2881 OH TYR A 366 -1.546 14.667 1.459 1.00 94.64 O \\\\nATOM 2882 CZ TYR A 366 -0.953 15.490 0.554 1.00 94.64 C \\\\nATOM 2883 N GLY A 367 0.293 20.740 -4.800 1.00 95.30 N \\\\nATOM 2884 CA GLY A 367 0.976 21.736 -5.634 1.00 95.30 C \\\\nATOM 2885 C GLY A 367 2.334 21.268 -6.168 1.00 95.30 C \\\\nATOM 2886 O GLY A 367 3.211 22.085 -6.441 1.00 95.30 O \\\\nATOM 2887 N TRP A 368 2.542 19.957 -6.288 1.00 95.17 N \\\\nATOM 2888 CA TRP A 368 3.743 19.377 -6.881 1.00 95.17 C \\\\nATOM 2889 C TRP A 368 3.590 19.216 -8.391 1.00 95.17 C \\\\nATOM 2890 CB TRP A 368 4.063 18.034 -6.218 1.00 95.17 C \\\\nATOM 2891 O TRP A 368 2.484 19.074 -8.910 1.00 95.17 O \\\\nATOM 2892 CG TRP A 368 4.353 18.072 -4.751 1.00 95.17 C \\\\nATOM 2893 CD1 TRP A 368 4.860 19.125 -4.069 1.00 95.17 C \\\\nATOM 2894 CD2 TRP A 368 4.110 17.033 -3.755 1.00 95.17 C \\\\nATOM 2895 CE2 TRP A 368 4.511 17.533 -2.480 1.00 95.17 C \\\\nATOM 2896 CE3 TRP A 368 3.550 15.737 -3.790 1.00 95.17 C \\\\nATOM 2897 NE1 TRP A 368 4.962 18.809 -2.732 1.00 95.17 N \\\\nATOM 2898 CH2 TRP A 368 3.799 15.509 -1.367 1.00 95.17 C \\\\nATOM 2899 CZ2 TRP A 368 4.378 16.786 -1.301 1.00 95.17 C \\\\nATOM 2900 CZ3 TRP A 368 3.374 14.997 -2.605 1.00 95.17 C \\\\nATOM 2901 N HIS A 369 4.722 19.151 -9.096 1.00 95.30 N \\\\nATOM 2902 CA HIS A 369 4.724 18.820 -10.518 1.00 95.30 C \\\\nATOM 2903 C HIS A 369 3.951 17.502 -10.767 1.00 95.30 C \\\\nATOM 2904 CB HIS A 369 6.175 18.730 -11.012 1.00 95.30 C \\\\nATOM 2905 O HIS A 369 4.157 16.543 -10.016 1.00 95.30 O \\\\nATOM 2906 CG HIS A 369 6.259 18.606 -12.508 1.00 95.30 C \\\\nATOM 2907 CD2 HIS A 369 6.255 19.634 -13.411 1.00 95.30 C \\\\nATOM 2908 ND1 HIS A 369 6.303 17.435 -13.227 1.00 95.30 N \\\\nATOM 2909 CE1 HIS A 369 6.308 17.747 -14.536 1.00 95.30 C \\\\nATOM 2910 NE2 HIS A 369 6.277 19.073 -14.687 1.00 95.30 N \\\\nATOM 2911 N PRO A 370 3.101 17.384 -11.811 1.00 93.40 N \\\\nATOM 2912 CA PRO A 370 2.279 16.186 -12.047 1.00 93.40 C \\\\nATOM 2913 C PRO A 370 3.077 14.876 -12.133 1.00 93.40 C \\\\nATOM 2914 CB PRO A 370 1.543 16.461 -13.362 1.00 93.40 C \\\\nATOM 2915 O PRO A 370 2.563 13.802 -11.826 1.00 93.40 O \\\\nATOM 2916 CG PRO A 370 1.414 17.981 -13.379 1.00 93.40 C \\\\nATOM 2917 CD PRO A 370 2.718 18.445 -12.736 1.00 93.40 C \\\\nATOM 2918 N ALA A 371 4.357 14.974 -12.496 1.00 94.38 N \\\\nATOM 2919 CA ALA A 371 5.297 13.861 -12.604 1.00 94.38 C \\\\nATOM 2920 C ALA A 371 5.973 13.426 -11.297 1.00 94.38 C \\\\nATOM 2921 CB ALA A 371 6.387 14.274 -13.578 1.00 94.38 C \\\\nATOM 2922 O ALA A 371 6.759 12.473 -11.329 1.00 94.38 O \\\\nATOM 2923 N THR A 372 5.744 14.139 -10.194 1.00 95.75 N \\\\nATOM 2924 CA THR A 372 6.399 13.888 -8.909 1.00 95.75 C \\\\nATOM 2925 C THR A 372 6.146 12.462 -8.433 1.00 95.75 C \\\\nATOM 2926 CB THR A 372 5.952 14.920 -7.865 1.00 95.75 C \\\\nATOM 2927 O THR A 372 5.046 11.922 -8.567 1.00 95.75 O \\\\nATOM 2928 CG2 THR A 372 6.466 14.662 -6.449 1.00 95.75 C \\\\nATOM 2929 OG1 THR A 372 6.486 16.161 -8.254 1.00 95.75 O \\\\nATOM 2930 N VAL A 373 7.196 11.851 -7.883 1.00 97.76 N \\\\nATOM 2931 CA VAL A 373 7.174 10.489 -7.352 1.00 97.76 C \\\\nATOM 2932 C VAL A 373 7.317 10.554 -5.835 1.00 97.76 C \\\\nATOM 2933 CB VAL A 373 8.270 9.626 -7.999 1.00 97.76 C \\\\nATOM 2934 O VAL A 373 8.382 10.863 -5.303 1.00 97.76 O \\\\nATOM 2935 CG1 VAL A 373 8.211 8.193 -7.461 1.00 97.76 C \\\\nATOM 2936 CG2 VAL A 373 8.108 9.574 -9.523 1.00 97.76 C \\\\nATOM 2937 N CYS A 374 6.238 10.243 -5.128 1.00 96.60 N \\\\nATOM 2938 CA CYS A 374 6.176 10.254 -3.674 1.00 96.60 C \\\\nATOM 2939 C CYS A 374 6.661 8.916 -3.110 1.00 96.60 C \\\\nATOM 2940 CB CYS A 374 4.736 10.540 -3.234 1.00 96.60 C \\\\nATOM 2941 O CYS A 374 6.140 7.856 -3.455 1.00 96.60 O \\\\nATOM 2942 SG CYS A 374 4.133 12.066 -4.000 1.00 96.60 S \\\\nATOM 2943 N LYS A 375 7.632 8.944 -2.196 1.00 97.82 N \\\\nATOM 2944 CA LYS A 375 8.061 7.751 -1.455 1.00 97.82 C \\\\nATOM 2945 C LYS A 375 7.115 7.495 -0.279 1.00 97.82 C \\\\nATOM 2946 CB LYS A 375 9.514 7.947 -1.006 1.00 97.82 C \\\\nATOM 2947 O LYS A 375 6.924 8.382 0.546 1.00 97.82 O \\\\nATOM 2948 CG LYS A 375 10.077 6.726 -0.267 1.00 97.82 C \\\\nATOM 2949 CD LYS A 375 11.522 7.007 0.156 1.00 97.82 C \\\\nATOM 2950 CE LYS A 375 12.114 5.801 0.888 1.00 97.82 C \\\\nATOM 2951 NZ LYS A 375 13.500 6.086 1.337 1.00 97.82 N \\\\nATOM 2952 N ILE A 376 6.602 6.272 -0.154 1.00 97.37 N \\\\nATOM 2953 CA ILE A 376 5.853 5.795 1.017 1.00 97.37 C \\\\nATOM 2954 C ILE A 376 6.740 4.781 1.759 1.00 97.37 C \\\\nATOM 2955 CB ILE A 376 4.485 5.196 0.624 1.00 97.37 C \\\\nATOM 2956 O ILE A 376 6.971 3.680 1.248 1.00 97.37 O \\\\nATOM 2957 CG1 ILE A 376 3.673 6.151 -0.281 1.00 97.37 C \\\\nATOM 2958 CG2 ILE A 376 3.690 4.828 1.893 1.00 97.37 C \\\\nATOM 2959 CD1 ILE A 376 2.346 5.562 -0.771 1.00 97.37 C \\\\nATOM 2960 N PRO A 377 7.299 5.143 2.929 1.00 97.58 N \\\\nATOM 2961 CA PRO A 377 8.103 4.230 3.740 1.00 97.58 C \\\\nATOM 2962 C PRO A 377 7.293 3.046 4.303 1.00 97.58 C \\\\nATOM 2963 CB PRO A 377 8.691 5.083 4.871 1.00 97.58 C \\\\nATOM 2964 O PRO A 377 6.067 3.136 4.395 1.00 97.58 O \\\\nATOM 2965 CG PRO A 377 8.623 6.511 4.334 1.00 97.58 C \\\\nATOM 2966 CD PRO A 377 7.356 6.487 3.489 1.00 97.58 C \\\\nATOM 2967 N PRO A 378 7.964 1.961 4.737 1.00 97.58 N \\\\nATOM 2968 CA PRO A 378 7.325 0.838 5.428 1.00 97.58 C \\\\nATOM 2969 C PRO A 378 6.428 1.283 6.590 1.00 97.58 C \\\\nATOM 2970 CB PRO A 378 8.480 -0.034 5.930 1.00 97.58 C \\\\nATOM 2971 O PRO A 378 6.843 2.075 7.434 1.00 97.58 O \\\\nATOM 2972 CG PRO A 378 9.568 0.224 4.894 1.00 97.58 C \\\\nATOM 2973 CD PRO A 378 9.391 1.707 4.591 1.00 97.58 C \\\\nATOM 2974 N GLY A 379 5.193 0.777 6.633 1.00 92.70 N \\\\nATOM 2975 CA GLY A 379 4.200 1.105 7.662 1.00 92.70 C \\\\nATOM 2976 C GLY A 379 3.500 2.459 7.491 1.00 92.70 C \\\\nATOM 2977 O GLY A 379 2.587 2.768 8.258 1.00 92.70 O \\\\nATOM 2978 N CYS A 380 3.885 3.268 6.500 1.00 95.04 N \\\\nATOM 2979 CA CYS A 380 3.205 4.520 6.177 1.00 95.04 C \\\\nATOM 2980 C CYS A 380 2.071 4.305 5.165 1.00 95.04 C \\\\nATOM 2981 CB CYS A 380 4.220 5.558 5.676 1.00 95.04 C \\\\nATOM 2982 O CYS A 380 2.049 3.328 4.415 1.00 95.04 O \\\\nATOM 2983 SG CYS A 380 5.459 5.922 6.954 1.00 95.04 S \\\\nATOM 2984 N ASN A 381 1.143 5.261 5.116 1.00 94.89 N \\\\nATOM 2985 CA ASN A 381 0.094 5.328 4.105 1.00 94.89 C \\\\nATOM 2986 C ASN A 381 0.009 6.730 3.486 1.00 94.89 C \\\\nATOM 2987 CB ASN A 381 -1.248 4.848 4.687 1.00 94.89 C \\\\nATOM 2988 O ASN A 381 0.466 7.703 4.085 1.00 94.89 O \\\\nATOM 2989 CG ASN A 381 -1.764 5.753 5.791 1.00 94.89 C \\\\nATOM 2990 ND2 ASN A 381 -1.454 5.453 7.031 1.00 94.89 N \\\\nATOM 2991 OD1 ASN A 381 -2.427 6.748 5.560 1.00 94.89 O \\\\nATOM 2992 N LEU A 382 -0.562 6.818 2.286 1.00 94.95 N \\\\nATOM 2993 CA LEU A 382 -0.778 8.062 1.549 1.00 94.95 C \\\\nATOM 2994 C LEU A 382 -2.145 8.028 0.863 1.00 94.95 C \\\\nATOM 2995 CB LEU A 382 0.357 8.226 0.521 1.00 94.95 C \\\\nATOM 2996 O LEU A 382 -2.516 7.012 0.275 1.00 94.95 O \\\\nATOM 2997 CG LEU A 382 0.314 9.514 -0.324 1.00 94.95 C \\\\nATOM 2998 CD1 LEU A 382 0.495 10.768 0.533 1.00 94.95 C \\\\nATOM 2999 CD2 LEU A 382 1.430 9.477 -1.368 1.00 94.95 C \\\\nATOM 3000 N LYS A 383 -2.872 9.150 0.889 1.00 96.88 N \\\\nATOM 3001 CA LYS A 383 -4.083 9.348 0.081 1.00 96.88 C \\\\nATOM 3002 C LYS A 383 -3.681 9.634 -1.363 1.00 96.88 C \\\\nATOM 3003 CB LYS A 383 -4.923 10.485 0.675 1.00 96.88 C \\\\nATOM 3004 O LYS A 383 -3.294 10.754 -1.690 1.00 96.88 O \\\\nATOM 3005 CG LYS A 383 -6.269 10.625 -0.058 1.00 96.88 C \\\\nATOM 3006 CD LYS A 383 -7.087 11.818 0.451 1.00 96.88 C \\\\nATOM 3007 CE LYS A 383 -7.420 11.669 1.938 1.00 96.88 C \\\\nATOM 3008 NZ LYS A 383 -8.317 12.746 2.405 1.00 96.88 N \\\\nATOM 3009 N ILE A 384 -3.771 8.626 -2.220 1.00 97.74 N \\\\nATOM 3010 CA ILE A 384 -3.300 8.703 -3.605 1.00 97.74 C \\\\nATOM 3011 C ILE A 384 -4.361 9.256 -4.559 1.00 97.74 C \\\\nATOM 3012 CB ILE A 384 -2.738 7.347 -4.082 1.00 97.74 C \\\\nATOM 3013 O ILE A 384 -3.991 9.710 -5.633 1.00 97.74 O \\\\nATOM 3014 CG1 ILE A 384 -3.828 6.254 -4.146 1.00 97.74 C \\\\nATOM 3015 CG2 ILE A 384 -1.557 6.924 -3.190 1.00 97.74 C \\\\nATOM 3016 CD1 ILE A 384 -3.349 4.937 -4.762 1.00 97.74 C \\\\nATOM 3017 N PHE A 385 -5.646 9.255 -4.196 1.00 97.98 N \\\\nATOM 3018 CA PHE A 385 -6.714 9.810 -5.034 1.00 97.98 C \\\\nATOM 3019 C PHE A 385 -7.903 10.309 -4.205 1.00 97.98 C \\\\nATOM 3020 CB PHE A 385 -7.190 8.749 -6.032 1.00 97.98 C \\\\nATOM 3021 O PHE A 385 -8.200 9.731 -3.159 1.00 97.98 O \\\\nATOM 3022 CG PHE A 385 -7.952 9.324 -7.205 1.00 97.98 C \\\\nATOM 3023 CD1 PHE A 385 -9.359 9.385 -7.181 1.00 97.98 C \\\\nATOM 3024 CD2 PHE A 385 -7.253 9.791 -8.333 1.00 97.98 C \\\\nATOM 3025 CE1 PHE A 385 -10.052 9.907 -8.285 1.00 97.98 C \\\\nATOM 3026 CE2 PHE A 385 -7.959 10.308 -9.432 1.00 97.98 C \\\\nATOM 3027 CZ PHE A 385 -9.358 10.352 -9.416 1.00 97.98 C \\\\nATOM 3028 N ASN A 386 -8.595 11.344 -4.681 1.00 95.89 N \\\\nATOM 3029 CA ASN A 386 -9.868 11.815 -4.134 1.00 95.89 C \\\\nATOM 3030 C ASN A 386 -10.840 12.167 -5.281 1.00 95.89 C \\\\nATOM 3031 CB ASN A 386 -9.582 12.993 -3.183 1.00 95.89 C \\\\nATOM 3032 O ASN A 386 -10.531 12.988 -6.148 1.00 95.89 O \\\\nATOM 3033 CG ASN A 386 -10.836 13.650 -2.638 1.00 95.89 C \\\\nATOM 3034 ND2 ASN A 386 -11.081 13.677 -1.353 1.00 95.89 N \\\\nATOM 3035 OD1 ASN A 386 -11.657 14.142 -3.385 1.00 95.89 O \\\\nATOM 3036 N ASN A 387 -12.028 11.554 -5.262 1.00 94.32 N \\\\nATOM 3037 CA ASN A 387 -13.050 11.721 -6.296 1.00 94.32 C \\\\nATOM 3038 C ASN A 387 -13.654 13.130 -6.338 1.00 94.32 C \\\\nATOM 3039 CB ASN A 387 -14.183 10.698 -6.083 1.00 94.32 C \\\\nATOM 3040 O ASN A 387 -14.024 13.580 -7.415 1.00 94.32 O \\\\nATOM 3041 CG ASN A 387 -13.870 9.277 -6.515 1.00 94.32 C \\\\nATOM 3042 ND2 ASN A 387 -14.802 8.374 -6.338 1.00 94.32 N \\\\nATOM 3043 OD1 ASN A 387 -12.814 8.959 -7.028 1.00 94.32 O \\\\nATOM 3044 N GLN A 388 -13.768 13.834 -5.209 1.00 93.82 N \\\\nATOM 3045 CA GLN A 388 -14.294 15.206 -5.180 1.00 93.82 C \\\\nATOM 3046 C GLN A 388 -13.327 16.188 -5.848 1.00 93.82 C \\\\nATOM 3047 CB GLN A 388 -14.558 15.666 -3.740 1.00 93.82 C \\\\nATOM 3048 O GLN A 388 -13.753 17.058 -6.602 1.00 93.82 O \\\\nATOM 3049 CG GLN A 388 -15.637 14.855 -3.015 1.00 93.82 C \\\\nATOM 3050 CD GLN A 388 -15.860 15.367 -1.596 1.00 93.82 C \\\\nATOM 3051 NE2 GLN A 388 -17.079 15.365 -1.111 1.00 93.82 N \\\\nATOM 3052 OE1 GLN A 388 -14.960 15.786 -0.891 1.00 93.82 O \\\\nATOM 3053 N GLU A 389 -12.024 16.024 -5.615 1.00 94.83 N \\\\nATOM 3054 CA GLU A 389 -10.987 16.821 -6.276 1.00 94.83 C \\\\nATOM 3055 C GLU A 389 -10.980 16.567 -7.786 1.00 94.83 C \\\\nATOM 3056 CB GLU A 389 -9.615 16.480 -5.684 1.00 94.83 C \\\\nATOM 3057 O GLU A 389 -10.916 17.509 -8.573 1.00 94.83 O \\\\nATOM 3058 CG GLU A 389 -9.465 16.962 -4.234 1.00 94.83 C \\\\nATOM 3059 CD GLU A 389 -8.200 16.419 -3.565 1.00 94.83 C \\\\nATOM 3060 OE1 GLU A 389 -8.029 16.604 -2.342 1.00 94.83 O \\\\nATOM 3061 OE2 GLU A 389 -7.391 15.714 -4.210 1.00 94.83 O \\\\nATOM 3062 N PHE A 390 -11.113 15.301 -8.197 1.00 96.24 N \\\\nATOM 3063 CA PHE A 390 -11.250 14.953 -9.609 1.00 96.24 C \\\\nATOM 3064 C PHE A 390 -12.540 15.514 -10.225 1.00 96.24 C \\\\nATOM 3065 CB PHE A 390 -11.166 13.434 -9.773 1.00 96.24 C \\\\nATOM 3066 O PHE A 390 -12.490 16.068 -11.317 1.00 96.24 O \\\\nATOM 3067 CG PHE A 390 -11.298 12.992 -11.217 1.00 96.24 C \\\\nATOM 3068 CD1 PHE A 390 -12.518 12.467 -11.688 1.00 96.24 C \\\\nATOM 3069 CD2 PHE A 390 -10.216 13.152 -12.103 1.00 96.24 C \\\\nATOM 3070 CE1 PHE A 390 -12.650 12.096 -13.038 1.00 96.24 C \\\\nATOM 3071 CE2 PHE A 390 -10.352 12.779 -13.452 1.00 96.24 C \\\\nATOM 3072 CZ PHE A 390 -11.566 12.248 -13.917 1.00 96.24 C \\\\nATOM 3073 N ALA A 391 -13.674 15.437 -9.519 1.00 94.09 N \\\\nATOM 3074 CA ALA A 391 -14.953 15.999 -9.956 1.00 94.09 C \\\\nATOM 3075 C ALA A 391 -14.858 17.504 -10.230 1.00 94.09 C \\\\nATOM 3076 CB ALA A 391 -15.999 15.773 -8.856 1.00 94.09 C \\\\nATOM 3077 O ALA A 391 -15.314 17.984 -11.267 1.00 94.09 O \\\\nATOM 3078 N ALA A 392 -14.256 18.246 -9.295 1.00 94.21 N \\\\nATOM 3079 CA ALA A 392 -14.075 19.686 -9.418 1.00 94.21 C \\\\nATOM 3080 C ALA A 392 -13.184 20.033 -10.617 1.00 94.21 C \\\\nATOM 3081 CB ALA A 392 -13.490 20.214 -8.103 1.00 94.21 C \\\\nATOM 3082 O ALA A 392 -13.516 20.936 -11.383 1.00 94.21 O \\\\nATOM 3083 N LEU A 393 -12.094 19.286 -10.811 1.00 94.52 N \\\\nATOM 3084 CA LEU A 393 -11.209 19.462 -11.958 1.00 94.52 C \\\\nATOM 3085 C LEU A 393 -11.916 19.143 -13.280 1.00 94.52 C \\\\nATOM 3086 CB LEU A 393 -9.968 18.587 -11.751 1.00 94.52 C \\\\nATOM 3087 O LEU A 393 -11.835 19.930 -14.214 1.00 94.52 O \\\\nATOM 3088 CG LEU A 393 -8.927 18.738 -12.870 1.00 94.52 C \\\\nATOM 3089 CD1 LEU A 393 -8.401 20.170 -12.984 1.00 94.52 C \\\\nATOM 3090 CD2 LEU A 393 -7.771 17.797 -12.558 1.00 94.52 C \\\\nATOM 3091 N LEU A 394 -12.662 18.038 -13.344 1.00 94.94 N \\\\nATOM 3092 CA LEU A 394 -13.439 17.651 -14.520 1.00 94.94 C \\\\nATOM 3093 C LEU A 394 -14.450 18.735 -14.906 1.00 94.94 C \\\\nATOM 3094 CB LEU A 394 -14.099 16.288 -14.237 1.00 94.94 C \\\\nATOM 3095 O LEU A 394 -14.493 19.146 -16.063 1.00 94.94 O \\\\nATOM 3096 CG LEU A 394 -14.979 15.742 -15.376 1.00 94.94 C \\\\nATOM 3097 CD1 LEU A 394 -14.211 15.600 -16.687 1.00 94.94 C \\\\nATOM 3098 CD2 LEU A 394 -15.510 14.362 -14.978 1.00 94.94 C \\\\nATOM 3099 N ALA A 395 -15.207 19.256 -13.937 1.00 93.07 N \\\\nATOM 3100 CA ALA A 395 -16.156 20.342 -14.169 1.00 93.07 C \\\\nATOM 3101 C ALA A 395 -15.480 21.632 -14.670 1.00 93.07 C \\\\nATOM 3102 CB ALA A 395 -16.929 20.587 -12.868 1.00 93.07 C \\\\nATOM 3103 O ALA A 395 -16.045 22.343 -15.498 1.00 93.07 O \\\\nATOM 3104 N GLN A 396 -14.266 21.935 -14.201 1.00 93.21 N \\\\nATOM 3105 CA GLN A 396 -13.488 23.081 -14.681 1.00 93.21 C \\\\nATOM 3106 C GLN A 396 -12.965 22.861 -16.107 1.00 93.21 C \\\\nATOM 3107 CB GLN A 396 -12.330 23.364 -13.715 1.00 93.21 C \\\\nATOM 3108 O GLN A 396 -13.097 23.755 -16.943 1.00 93.21 O \\\\nATOM 3109 CG GLN A 396 -12.817 23.965 -12.389 1.00 93.21 C \\\\nATOM 3110 CD GLN A 396 -11.714 24.049 -11.337 1.00 93.21 C \\\\nATOM 3111 NE2 GLN A 396 -12.058 24.325 -10.098 1.00 93.21 N \\\\nATOM 3112 OE1 GLN A 396 -10.531 23.896 -11.587 1.00 93.21 O \\\\nATOM 3113 N SER A 397 -12.420 21.677 -16.400 1.00 93.63 N \\\\nATOM 3114 CA SER A 397 -11.832 21.340 -17.702 1.00 93.63 C \\\\nATOM 3115 C SER A 397 -12.854 21.267 -18.834 1.00 93.63 C \\\\nATOM 3116 CB SER A 397 -11.082 20.010 -17.619 1.00 93.63 C \\\\nATOM 3117 O SER A 397 -12.492 21.547 -19.971 1.00 93.63 O \\\\nATOM 3118 OG SER A 397 -9.968 20.134 -16.755 1.00 93.63 O \\\\nATOM 3119 N VAL A 398 -14.131 20.978 -18.552 1.00 91.77 N \\\\nATOM 3120 CA VAL A 398 -15.205 21.048 -19.564 1.00 91.77 C \\\\nATOM 3121 C VAL A 398 -15.265 22.425 -20.234 1.00 91.77 C \\\\nATOM 3122 CB VAL A 398 -16.559 20.665 -18.938 1.00 91.77 C \\\\nATOM 3123 O VAL A 398 -15.428 22.509 -21.448 1.00 91.77 O \\\\nATOM 3124 CG1 VAL A 398 -17.769 21.034 -19.801 1.00 91.77 C \\\\nATOM 3125 CG2 VAL A 398 -16.616 19.149 -18.736 1.00 91.77 C \\\\nATOM 3126 N ASN A 399 -15.031 23.506 -19.484 1.00 88.71 N \\\\nATOM 3127 CA ASN A 399 -15.034 24.867 -20.034 1.00 88.71 C \\\\nATOM 3128 C ASN A 399 -13.769 25.208 -20.843 1.00 88.71 C \\\\nATOM 3129 CB ASN A 399 -15.237 25.870 -18.890 1.00 88.71 C \\\\nATOM 3130 O ASN A 399 -13.734 26.231 -21.518 1.00 88.71 O \\\\nATOM 3131 CG ASN A 399 -16.513 25.607 -18.116 1.00 88.71 C \\\\nATOM 3132 ND2 ASN A 399 -16.405 25.322 -16.841 1.00 88.71 N \\\\nATOM 3133 OD1 ASN A 399 -17.610 25.615 -18.643 1.00 88.71 O \\\\nATOM 3134 N GLN A 400 -12.726 24.377 -20.767 1.00 90.24 N \\\\nATOM 3135 CA GLN A 400 -11.464 24.554 -21.497 1.00 90.24 C \\\\nATOM 3136 C GLN A 400 -11.454 23.802 -22.840 1.00 90.24 C \\\\nATOM 3137 CB GLN A 400 -10.297 24.102 -20.607 1.00 90.24 C \\\\nATOM 3138 O GLN A 400 -10.539 23.982 -23.641 1.00 90.24 O \\\\nATOM 3139 CG GLN A 400 -10.160 24.910 -19.309 1.00 90.24 C \\\\nATOM 3140 CD GLN A 400 -9.090 24.349 -18.376 1.00 90.24 C \\\\nATOM 3141 NE2 GLN A 400 -8.996 24.853 -17.167 1.00 90.24 N \\\\nATOM 3142 OE1 GLN A 400 -8.341 23.435 -18.680 1.00 90.24 O \\\\nATOM 3143 N GLY A 401 -12.472 22.976 -23.102 1.00 89.27 N \\\\nATOM 3144 CA GLY A 401 -12.641 22.243 -24.353 1.00 89.27 C \\\\nATOM 3145 C GLY A 401 -12.207 20.776 -24.292 1.00 89.27 C \\\\nATOM 3146 O GLY A 401 -11.748 20.264 -23.271 1.00 89.27 O \\\\nATOM 3147 N PHE A 402 -12.382 20.086 -25.421 1.00 90.38 N \\\\nATOM 3148 CA PHE A 402 -12.212 18.635 -25.535 1.00 90.38 C \\\\nATOM 3149 C PHE A 402 -10.825 18.148 -25.092 1.00 90.38 C \\\\nATOM 3150 CB PHE A 402 -12.499 18.227 -26.989 1.00 90.38 C \\\\nATOM 3151 O PHE A 402 -10.730 17.192 -24.327 1.00 90.38 O \\\\nATOM 3152 CG PHE A 402 -12.438 16.732 -27.227 1.00 90.38 C \\\\nATOM 3153 CD1 PHE A 402 -11.204 16.100 -27.479 1.00 90.38 C \\\\nATOM 3154 CD2 PHE A 402 -13.615 15.964 -27.177 1.00 90.38 C \\\\nATOM 3155 CE1 PHE A 402 -11.148 14.707 -27.666 1.00 90.38 C \\\\nATOM 3156 CE2 PHE A 402 -13.560 14.573 -27.372 1.00 90.38 C \\\\nATOM 3157 CZ PHE A 402 -12.327 13.944 -27.616 1.00 90.38 C \\\\nATOM 3158 N GLU A 403 -9.752 18.816 -25.531 1.00 91.17 N \\\\nATOM 3159 CA GLU A 403 -8.376 18.393 -25.238 1.00 91.17 C \\\\nATOM 3160 C GLU A 403 -8.076 18.432 -23.734 1.00 91.17 C \\\\nATOM 3161 CB GLU A 403 -7.395 19.281 -26.026 1.00 91.17 C \\\\nATOM 3162 O GLU A 403 -7.521 17.483 -23.187 1.00 91.17 O \\\\nATOM 3163 CG GLU A 403 -5.925 18.840 -25.911 1.00 91.17 C \\\\nATOM 3164 CD GLU A 403 -5.677 17.399 -26.387 1.00 91.17 C \\\\nATOM 3165 OE1 GLU A 403 -4.748 16.760 -25.836 1.00 91.17 O \\\\nATOM 3166 OE2 GLU A 403 -6.428 16.933 -27.273 1.00 91.17 O \\\\nATOM 3167 N ALA A 404 -8.515 19.483 -23.035 1.00 92.62 N \\\\nATOM 3168 CA ALA A 404 -8.321 19.609 -21.593 1.00 92.62 C \\\\nATOM 3169 C ALA A 404 -9.007 18.472 -20.823 1.00 92.62 C \\\\nATOM 3170 CB ALA A 404 -8.858 20.971 -21.154 1.00 92.62 C \\\\nATOM 3171 O ALA A 404 -8.413 17.896 -19.912 1.00 92.62 O \\\\nATOM 3172 N VAL A 405 -10.231 18.107 -21.221 1.00 93.34 N \\\\nATOM 3173 CA VAL A 405 -10.944 16.953 -20.659 1.00 93.34 C \\\\nATOM 3174 C VAL A 405 -10.209 15.657 -21.007 1.00 93.34 C \\\\nATOM 3175 CB VAL A 405 -12.409 16.916 -21.137 1.00 93.34 C \\\\nATOM 3176 O VAL A 405 -9.949 14.849 -20.123 1.00 93.34 O \\\\nATOM 3177 CG1 VAL A 405 -13.168 15.723 -20.550 1.00 93.34 C \\\\nATOM 3178 CG2 VAL A 405 -13.171 18.174 -20.705 1.00 93.34 C \\\\nATOM 3179 N TYR A 406 -9.798 15.465 -22.260 1.00 92.37 N \\\\nATOM 3180 CA TYR A 406 -9.100 14.254 -22.696 1.00 92.37 C \\\\nATOM 3181 C TYR A 406 -7.802 14.006 -21.904 1.00 92.37 C \\\\nATOM 3182 CB TYR A 406 -8.839 14.353 -24.203 1.00 92.37 C \\\\nATOM 3183 O TYR A 406 -7.530 12.876 -21.483 1.00 92.37 O \\\\nATOM 3184 CG TYR A 406 -8.253 13.085 -24.782 1.00 92.37 C \\\\nATOM 3185 CD1 TYR A 406 -6.866 12.983 -24.999 1.00 92.37 C \\\\nATOM 3186 CD2 TYR A 406 -9.099 12.000 -25.083 1.00 92.37 C \\\\nATOM 3187 CE1 TYR A 406 -6.320 11.791 -25.513 1.00 92.37 C \\\\nATOM 3188 CE2 TYR A 406 -8.557 10.807 -25.597 1.00 92.37 C \\\\nATOM 3189 OH TYR A 406 -6.648 9.555 -26.324 1.00 92.37 O \\\\nATOM 3190 CZ TYR A 406 -7.168 10.702 -25.813 1.00 92.37 C \\\\nATOM 3191 N GLN A 407 -7.043 15.062 -21.594 1.00 92.56 N \\\\nATOM 3192 CA GLN A 407 -5.833 14.987 -20.766 1.00 92.56 C \\\\nATOM 3193 C GLN A 407 -6.097 14.491 -19.332 1.00 92.56 C \\\\nATOM 3194 CB GLN A 407 -5.140 16.361 -20.741 1.00 92.56 C \\\\nATOM 3195 O GLN A 407 -5.215 13.866 -18.729 1.00 92.56 O \\\\nATOM 3196 CG GLN A 407 -4.521 16.759 -22.093 1.00 92.56 C \\\\nATOM 3197 CD GLN A 407 -3.387 15.857 -22.554 1.00 92.56 C \\\\nATOM 3198 NE2 GLN A 407 -3.095 15.834 -23.833 1.00 92.56 N \\\\nATOM 3199 OE1 GLN A 407 -2.752 15.147 -21.784 1.00 92.56 O \\\\nATOM 3200 N LEU A 408 -7.314 14.661 -18.794 1.00 94.48 N \\\\nATOM 3201 CA LEU A 408 -7.694 14.129 -17.477 1.00 94.48 C \\\\nATOM 3202 C LEU A 408 -7.704 12.599 -17.416 1.00 94.48 C \\\\nATOM 3203 CB LEU A 408 -9.060 14.664 -17.020 1.00 94.48 C \\\\nATOM 3204 O LEU A 408 -7.690 12.040 -16.318 1.00 94.48 O \\\\nATOM 3205 CG LEU A 408 -9.156 16.186 -16.858 1.00 94.48 C \\\\nATOM 3206 CD1 LEU A 408 -10.550 16.528 -16.344 1.00 94.48 C \\\\nATOM 3207 CD2 LEU A 408 -8.130 16.720 -15.861 1.00 94.48 C \\\\nATOM 3208 N THR A 409 -7.622 11.906 -18.555 1.00 94.82 N \\\\nATOM 3209 CA THR A 409 -7.381 10.454 -18.586 1.00 94.82 C \\\\nATOM 3210 C THR A 409 -6.137 10.100 -17.766 1.00 94.82 C \\\\nATOM 3211 CB THR A 409 -7.208 9.953 -20.028 1.00 94.82 C \\\\nATOM 3212 O THR A 409 -6.144 9.133 -17.007 1.00 94.82 O \\\\nATOM 3213 CG2 THR A 409 -7.149 8.427 -20.100 1.00 94.82 C \\\\nATOM 3214 OG1 THR A 409 -8.301 10.347 -20.817 1.00 94.82 O \\\\nATOM 3215 N ARG A 410 -5.094 10.946 -17.816 1.00 93.13 N \\\\nATOM 3216 CA ARG A 410 -3.854 10.766 -17.042 1.00 93.13 C \\\\nATOM 3217 C ARG A 410 -4.078 10.857 -15.534 1.00 93.13 C \\\\nATOM 3218 CB ARG A 410 -2.806 11.807 -17.467 1.00 93.13 C \\\\nATOM 3219 O ARG A 410 -3.379 10.185 -14.784 1.00 93.13 O \\\\nATOM 3220 CG ARG A 410 -2.404 11.694 -18.945 1.00 93.13 C \\\\nATOM 3221 CD ARG A 410 -1.350 12.752 -19.299 1.00 93.13 C \\\\nATOM 3222 NE ARG A 410 -0.998 12.695 -20.728 1.00 93.13 N \\\\nATOM 3223 NH1 ARG A 410 0.238 14.644 -20.846 1.00 93.13 N \\\\nATOM 3224 NH2 ARG A 410 -0.291 13.571 -22.708 1.00 93.13 N \\\\nATOM 3225 CZ ARG A 410 -0.356 13.632 -21.409 1.00 93.13 C \\\\nATOM 3226 N MET A 411 -5.054 11.647 -15.081 1.00 94.91 N \\\\nATOM 3227 CA MET A 411 -5.395 11.753 -13.657 1.00 94.91 C \\\\nATOM 3228 C MET A 411 -5.948 10.439 -13.107 1.00 94.91 C \\\\nATOM 3229 CB MET A 411 -6.416 12.876 -13.415 1.00 94.91 C \\\\nATOM 3230 O MET A 411 -5.793 10.166 -11.920 1.00 94.91 O \\\\nATOM 3231 CG MET A 411 -5.905 14.262 -13.817 1.00 94.91 C \\\\nATOM 3232 SD MET A 411 -4.534 14.885 -12.816 1.00 94.91 S \\\\nATOM 3233 CE MET A 411 -5.412 15.315 -11.297 1.00 94.91 C \\\\nATOM 3234 N CYS A 412 -6.558 9.620 -13.965 1.00 96.87 N \\\\nATOM 3235 CA CYS A 412 -7.174 8.354 -13.588 1.00 96.87 C \\\\nATOM 3236 C CYS A 412 -6.182 7.176 -13.543 1.00 96.87 C \\\\nATOM 3237 CB CYS A 412 -8.323 8.061 -14.551 1.00 96.87 C \\\\nATOM 3238 O CYS A 412 -6.571 6.071 -13.153 1.00 96.87 O \\\\nATOM 3239 SG CYS A 412 -9.484 9.454 -14.693 1.00 96.87 S \\\\nATOM 3240 N THR A 413 -4.917 7.407 -13.918 1.00 97.46 N \\\\nATOM 3241 CA THR A 413 -3.845 6.408 -13.909 1.00 97.46 C \\\\nATOM 3242 C THR A 413 -2.819 6.731 -12.826 1.00 97.46 C \\\\nATOM 3243 CB THR A 413 -3.174 6.281 -15.284 1.00 97.46 C \\\\nATOM 3244 O THR A 413 -2.224 7.807 -12.805 1.00 97.46 O \\\\nATOM 3245 CG2 THR A 413 -2.057 5.237 -15.300 1.00 97.46 C \\\\nATOM 3246 OG1 THR A 413 -4.123 5.875 -16.241 1.00 97.46 O \\\\nATOM 3247 N ILE A 414 -2.566 5.773 -11.934 1.00 98.40 N \\\\nATOM 3248 CA ILE A 414 -1.571 5.888 -10.861 1.00 98.40 C \\\\nATOM 3249 C ILE A 414 -0.518 4.805 -11.048 1.00 98.40 C \\\\nATOM 3250 CB ILE A 414 -2.229 5.818 -9.466 1.00 98.40 C \\\\nATOM 3251 O ILE A 414 -0.847 3.631 -11.200 1.00 98.40 O \\\\nATOM 3252 CG1 ILE A 414 -3.288 6.932 -9.308 1.00 98.40 C \\\\nATOM 3253 CG2 ILE A 414 -1.145 5.904 -8.372 1.00 98.40 C \\\\nATOM 3254 CD1 ILE A 414 -4.102 6.848 -8.014 1.00 98.40 C \\\\nATOM 3255 N ARG A 415 0.762 5.174 -10.987 1.00 98.53 N \\\\nATOM 3256 CA ARG A 415 1.872 4.219 -11.121 1.00 98.53 C \\\\nATOM 3257 C ARG A 415 2.588 4.041 -9.800 1.00 98.53 C \\\\nATOM 3258 CB ARG A 415 2.820 4.644 -12.244 1.00 98.53 C \\\\nATOM 3259 O ARG A 415 2.842 5.023 -9.102 1.00 98.53 O \\\\nATOM 3260 CG ARG A 415 2.070 4.671 -13.580 1.00 98.53 C \\\\nATOM 3261 CD ARG A 415 3.027 4.946 -14.731 1.00 98.53 C \\\\nATOM 3262 NE ARG A 415 2.281 4.998 -15.992 1.00 98.53 N \\\\nATOM 3263 NH1 ARG A 415 2.570 7.221 -16.554 1.00 98.53 N \\\\nATOM 3264 NH2 ARG A 415 1.353 5.820 -17.837 1.00 98.53 N \\\\nATOM 3265 CZ ARG A 415 2.087 6.027 -16.786 1.00 98.53 C \\\\nATOM 3266 N MET A 416 2.925 2.800 -9.456 1.00 98.54 N \\\\nATOM 3267 CA MET A 416 3.635 2.491 -8.216 1.00 98.54 C \\\\nATOM 3268 C MET A 416 4.779 1.514 -8.450 1.00 98.54 C \\\\nATOM 3269 CB MET A 416 2.700 1.961 -7.119 1.00 98.54 C \\\\nATOM 3270 O MET A 416 4.558 0.423 -8.959 1.00 98.54 O \\\\nATOM 3271 CG MET A 416 1.465 2.837 -6.929 1.00 98.54 C \\\\nATOM 3272 SD MET A 416 0.417 2.357 -5.534 1.00 98.54 S \\\\nATOM 3273 CE MET A 416 -1.180 2.527 -6.374 1.00 98.54 C \\\\nATOM 3274 N SER A 417 5.989 1.874 -8.031 1.00 98.68 N \\\\nATOM 3275 CA SER A 417 7.156 0.987 -8.055 1.00 98.68 C \\\\nATOM 3276 C SER A 417 7.431 0.411 -6.673 1.00 98.68 C \\\\nATOM 3277 CB SER A 417 8.388 1.709 -8.591 1.00 98.68 C \\\\nATOM 3278 O SER A 417 7.337 1.110 -5.659 1.00 98.68 O \\\\nATOM 3279 OG SER A 417 9.519 0.869 -8.532 1.00 98.68 O \\\\nATOM 3280 N PHE A 418 7.828 -0.858 -6.638 1.00 98.70 N \\\\nATOM 3281 CA PHE A 418 8.259 -1.538 -5.425 1.00 98.70 C \\\\nATOM 3282 C PHE A 418 9.772 -1.417 -5.254 1.00 98.70 C \\\\nATOM 3283 CB PHE A 418 7.837 -3.009 -5.470 1.00 98.70 C \\\\nATOM 3284 O PHE A 418 10.532 -1.666 -6.191 1.00 98.70 O \\\\nATOM 3285 CG PHE A 418 6.342 -3.225 -5.552 1.00 98.70 C \\\\nATOM 3286 CD1 PHE A 418 5.569 -3.241 -4.376 1.00 98.70 C \\\\nATOM 3287 CD2 PHE A 418 5.721 -3.406 -6.801 1.00 98.70 C \\\\nATOM 3288 CE1 PHE A 418 4.181 -3.446 -4.448 1.00 98.70 C \\\\nATOM 3289 CE2 PHE A 418 4.333 -3.607 -6.870 1.00 98.70 C \\\\nATOM 3290 CZ PHE A 418 3.561 -3.627 -5.696 1.00 98.70 C \\\\nATOM 3291 N VAL A 419 10.227 -1.120 -4.030 1.00 98.25 N \\\\nATOM 3292 CA VAL A 419 11.637 -1.131 -3.584 1.00 98.25 C \\\\nATOM 3293 C VAL A 419 12.523 -0.048 -4.215 1.00 98.25 C \\\\nATOM 3294 CB VAL A 419 12.276 -2.522 -3.799 1.00 98.25 C \\\\nATOM 3295 O VAL A 419 13.370 0.525 -3.529 1.00 98.25 O \\\\nATOM 3296 CG1 VAL A 419 13.640 -2.667 -3.112 1.00 98.25 C \\\\nATOM 3297 CG2 VAL A 419 11.402 -3.700 -3.340 1.00 98.25 C \\\\nATOM 3298 N LYS A 420 12.376 0.248 -5.511 1.00 97.93 N \\\\nATOM 3299 CA LYS A 420 13.226 1.176 -6.269 1.00 97.93 C \\\\nATOM 3300 C LYS A 420 12.432 2.405 -6.714 1.00 97.93 C \\\\nATOM 3301 CB LYS A 420 13.845 0.453 -7.483 1.00 97.93 C \\\\nATOM 3302 O LYS A 420 11.447 2.270 -7.432 1.00 97.93 O \\\\nATOM 3303 CG LYS A 420 14.640 -0.827 -7.164 1.00 97.93 C \\\\nATOM 3304 CD LYS A 420 15.786 -0.620 -6.162 1.00 97.93 C \\\\nATOM 3305 CE LYS A 420 16.542 -1.940 -5.960 1.00 97.93 C \\\\nATOM 3306 NZ LYS A 420 17.556 -1.843 -4.877 1.00 97.93 N \\\\nATOM 3307 N GLY A 421 12.905 3.593 -6.345 1.00 96.38 N \\\\nATOM 3308 CA GLY A 421 12.352 4.863 -6.819 1.00 96.38 C \\\\nATOM 3309 C GLY A 421 12.787 5.220 -8.239 1.00 96.38 C \\\\nATOM 3310 O GLY A 421 13.769 4.675 -8.761 1.00 96.38 O \\\\nATOM 3311 N TRP A 422 12.042 6.146 -8.838 1.00 98.03 N \\\\nATOM 3312 CA TRP A 422 12.339 6.792 -10.116 1.00 98.03 C \\\\nATOM 3313 C TRP A 422 11.929 8.271 -10.069 1.00 98.03 C \\\\nATOM 3314 CB TRP A 422 11.632 6.065 -11.270 1.00 98.03 C \\\\nATOM 3315 O TRP A 422 11.267 8.695 -9.122 1.00 98.03 O \\\\nATOM 3316 CG TRP A 422 10.193 6.426 -11.478 1.00 98.03 C \\\\nATOM 3317 CD1 TRP A 422 9.735 7.303 -12.401 1.00 98.03 C \\\\nATOM 3318 CD2 TRP A 422 9.016 5.985 -10.737 1.00 98.03 C \\\\nATOM 3319 CE2 TRP A 422 7.867 6.612 -11.307 1.00 98.03 C \\\\nATOM 3320 CE3 TRP A 422 8.800 5.122 -9.642 1.00 98.03 C \\\\nATOM 3321 NE1 TRP A 422 8.363 7.409 -12.311 1.00 98.03 N \\\\nATOM 3322 CH2 TRP A 422 6.387 5.528 -9.740 1.00 98.03 C \\\\nATOM 3323 CZ2 TRP A 422 6.571 6.373 -10.842 1.00 98.03 C \\\\nATOM 3324 CZ3 TRP A 422 7.500 4.913 -9.146 1.00 98.03 C \\\\nATOM 3325 N GLY A 423 12.309 9.041 -11.083 1.00 94.75 N \\\\nATOM 3326 CA GLY A 423 12.044 10.475 -11.190 1.00 94.75 C \\\\nATOM 3327 C GLY A 423 13.250 11.323 -10.786 1.00 94.75 C \\\\nATOM 3328 O GLY A 423 14.344 10.795 -10.600 1.00 94.75 O \\\\nATOM 3329 N ALA A 424 13.032 12.634 -10.641 1.00 90.85 N \\\\nATOM 3330 CA ALA A 424 14.086 13.644 -10.487 1.00 90.85 C \\\\nATOM 3331 C ALA A 424 15.119 13.325 -9.386 1.00 90.85 C \\\\nATOM 3332 CB ALA A 424 13.394 14.987 -10.215 1.00 90.85 C \\\\nATOM 3333 O ALA A 424 16.310 13.545 -9.571 1.00 90.85 O \\\\nATOM 3334 N GLU A 425 14.673 12.721 -8.282 1.00 88.72 N \\\\nATOM 3335 CA GLU A 425 15.503 12.405 -7.109 1.00 88.72 C \\\\nATOM 3336 C GLU A 425 16.249 11.058 -7.203 1.00 88.72 C \\\\nATOM 3337 CB GLU A 425 14.613 12.434 -5.855 1.00 88.72 C \\\\nATOM 3338 O GLU A 425 16.893 10.619 -6.248 1.00 88.72 O \\\\nATOM 3339 CG GLU A 425 13.885 13.769 -5.639 1.00 88.72 C \\\\nATOM 3340 CD GLU A 425 14.850 14.961 -5.596 1.00 88.72 C \\\\nATOM 3341 OE1 GLU A 425 14.500 15.996 -6.201 1.00 88.72 O \\\\nATOM 3342 OE2 GLU A 425 15.920 14.809 -4.965 1.00 88.72 O \\\\nATOM 3343 N TYR A 426 16.141 10.341 -8.325 1.00 94.62 N \\\\nATOM 3344 CA TYR A 426 16.680 8.990 -8.470 1.00 94.62 C \\\\nATOM 3345 C TYR A 426 17.466 8.829 -9.770 1.00 94.62 C \\\\nATOM 3346 CB TYR A 426 15.548 7.953 -8.380 1.00 94.62 C \\\\nATOM 3347 O TYR A 426 17.192 9.450 -10.787 1.00 94.62 O \\\\nATOM 3348 CG TYR A 426 14.758 7.996 -7.084 1.00 94.62 C \\\\nATOM 3349 CD1 TYR A 426 15.210 7.314 -5.935 1.00 94.62 C \\\\nATOM 3350 CD2 TYR A 426 13.601 8.790 -7.013 1.00 94.62 C \\\\nATOM 3351 CE1 TYR A 426 14.518 7.457 -4.715 1.00 94.62 C \\\\nATOM 3352 CE2 TYR A 426 12.900 8.928 -5.804 1.00 94.62 C \\\\nATOM 3353 OH TYR A 426 12.775 8.538 -3.454 1.00 94.62 O \\\\nATOM 3354 CZ TYR A 426 13.380 8.292 -4.645 1.00 94.62 C \\\\nATOM 3355 N ARG A 427 18.413 7.880 -9.782 1.00 94.90 N \\\\nATOM 3356 CA ARG A 427 19.152 7.509 -11.005 1.00 94.90 C \\\\nATOM 3357 C ARG A 427 18.225 7.072 -12.151 1.00 94.90 C \\\\nATOM 3358 CB ARG A 427 20.176 6.414 -10.660 1.00 94.90 C \\\\nATOM 3359 O ARG A 427 18.559 7.251 -13.317 1.00 94.90 O \\\\nATOM 3360 CG ARG A 427 21.004 5.978 -11.879 1.00 94.90 C \\\\nATOM 3361 CD ARG A 427 22.040 4.915 -11.509 1.00 94.90 C \\\\nATOM 3362 NE ARG A 427 22.699 4.393 -12.720 1.00 94.90 N \\\\nATOM 3363 NH1 ARG A 427 23.904 2.705 -11.734 1.00 94.90 N \\\\nATOM 3364 NH2 ARG A 427 24.039 3.017 -13.941 1.00 94.90 N \\\\nATOM 3365 CZ ARG A 427 23.540 3.376 -12.793 1.00 94.90 C \\\\nATOM 3366 N ARG A 428 17.099 6.434 -11.823 1.00 96.14 N \\\\nATOM 3367 CA ARG A 428 16.100 5.985 -12.799 1.00 96.14 C \\\\nATOM 3368 C ARG A 428 15.198 7.158 -13.132 1.00 96.14 C \\\\nATOM 3369 CB ARG A 428 15.268 4.838 -12.216 1.00 96.14 C \\\\nATOM 3370 O ARG A 428 14.451 7.585 -12.263 1.00 96.14 O \\\\nATOM 3371 CG ARG A 428 16.093 3.561 -12.091 1.00 96.14 C \\\\nATOM 3372 CD ARG A 428 15.265 2.482 -11.392 1.00 96.14 C \\\\nATOM 3373 NE ARG A 428 16.005 1.210 -11.355 1.00 96.14 N \\\\nATOM 3374 NH1 ARG A 428 17.371 1.723 -9.587 1.00 96.14 N \\\\nATOM 3375 NH2 ARG A 428 17.678 -0.190 -10.713 1.00 96.14 N \\\\nATOM 3376 CZ ARG A 428 17.010 0.917 -10.552 1.00 96.14 C \\\\nATOM 3377 N GLN A 429 15.240 7.633 -14.370 1.00 95.89 N \\\\nATOM 3378 CA GLN A 429 14.371 8.733 -14.772 1.00 95.89 C \\\\nATOM 3379 C GLN A 429 12.954 8.245 -15.040 1.00 95.89 C \\\\nATOM 3380 CB GLN A 429 14.980 9.512 -15.947 1.00 95.89 C \\\\nATOM 3381 O GLN A 429 12.033 8.853 -14.522 1.00 95.89 O \\\\nATOM 3382 CG GLN A 429 16.301 10.202 -15.553 1.00 95.89 C \\\\nATOM 3383 CD GLN A 429 16.155 11.065 -14.298 1.00 95.89 C \\\\nATOM 3384 NE2 GLN A 429 17.031 10.926 -13.331 1.00 95.89 N \\\\nATOM 3385 OE1 GLN A 429 15.202 11.803 -14.129 1.00 95.89 O \\\\nATOM 3386 N THR A 430 12.769 7.111 -15.726 1.00 96.48 N \\\\nATOM 3387 CA THR A 430 11.447 6.572 -16.089 1.00 96.48 C \\\\nATOM 3388 C THR A 430 10.968 5.455 -15.162 1.00 96.48 C \\\\nATOM 3389 CB THR A 430 11.421 6.056 -17.537 1.00 96.48 C \\\\nATOM 3390 O THR A 430 11.773 4.695 -14.610 1.00 96.48 O \\\\nATOM 3391 CG2 THR A 430 11.843 7.080 -18.590 1.00 96.48 C \\\\nATOM 3392 OG1 THR A 430 12.267 4.932 -17.662 1.00 96.48 O \\\\nATOM 3393 N VAL A 431 9.646 5.283 -15.053 1.00 97.27 N \\\\nATOM 3394 CA VAL A 431 9.054 4.138 -14.332 1.00 97.27 C \\\\nATOM 3395 C VAL A 431 9.428 2.805 -14.989 1.00 97.27 C \\\\nATOM 3396 CB VAL A 431 7.529 4.293 -14.205 1.00 97.27 C \\\\nATOM 3397 O VAL A 431 9.712 1.830 -14.299 1.00 97.27 O \\\\nATOM 3398 CG1 VAL A 431 6.798 4.130 -15.543 1.00 97.27 C \\\\nATOM 3399 CG2 VAL A 431 6.972 3.310 -13.171 1.00 97.27 C \\\\nATOM 3400 N THR A 432 9.565 2.786 -16.317 1.00 97.83 N \\\\nATOM 3401 CA THR A 432 9.991 1.622 -17.112 1.00 97.83 C \\\\nATOM 3402 C THR A 432 11.432 1.181 -16.834 1.00 97.83 C \\\\nATOM 3403 CB THR A 432 9.828 1.917 -18.611 1.00 97.83 C \\\\nATOM 3404 O THR A 432 11.830 0.084 -17.210 1.00 97.83 O \\\\nATOM 3405 CG2 THR A 432 8.359 2.070 -19.004 1.00 97.83 C \\\\nATOM 3406 OG1 THR A 432 10.470 3.129 -18.958 1.00 97.83 O \\\\nATOM 3407 N SER A 433 12.220 1.998 -16.126 1.00 97.46 N \\\\nATOM 3408 CA SER A 433 13.549 1.621 -15.624 1.00 97.46 C \\\\nATOM 3409 C SER A 433 13.496 0.910 -14.263 1.00 97.46 C \\\\nATOM 3410 CB SER A 433 14.424 2.869 -15.505 1.00 97.46 C \\\\nATOM 3411 O SER A 433 14.527 0.454 -13.744 1.00 97.46 O \\\\nATOM 3412 OG SER A 433 14.595 3.524 -16.742 1.00 97.46 O \\\\nATOM 3413 N THR A 434 12.325 0.861 -13.621 1.00 98.11 N \\\\nATOM 3414 CA THR A 434 12.142 0.204 -12.325 1.00 98.11 C \\\\nATOM 3415 C THR A 434 11.928 -1.301 -12.509 1.00 98.11 C \\\\nATOM 3416 CB THR A 434 11.031 0.812 -11.463 1.00 98.11 C \\\\nATOM 3417 O THR A 434 11.259 -1.723 -13.452 1.00 98.11 O \\\\nATOM 3418 CG2 THR A 434 11.186 2.317 -11.262 1.00 98.11 C \\\\nATOM 3419 OG1 THR A 434 9.764 0.546 -11.980 1.00 98.11 O \\\\nATOM 3420 N PRO A 435 12.504 -2.154 -11.642 1.00 98.30 N \\\\nATOM 3421 CA PRO A 435 12.450 -3.596 -11.871 1.00 98.30 C \\\\nATOM 3422 C PRO A 435 11.050 -4.194 -11.694 1.00 98.30 C \\\\nATOM 3423 CB PRO A 435 13.442 -4.209 -10.878 1.00 98.30 C \\\\nATOM 3424 O PRO A 435 10.746 -5.203 -12.319 1.00 98.30 O \\\\nATOM 3425 CG PRO A 435 14.335 -3.047 -10.462 1.00 98.30 C \\\\nATOM 3426 CD PRO A 435 13.396 -1.854 -10.532 1.00 98.30 C \\\\nATOM 3427 N CYS A 436 10.221 -3.614 -10.823 1.00 98.65 N \\\\nATOM 3428 CA CYS A 436 8.884 -4.108 -10.502 1.00 98.65 C \\\\nATOM 3429 C CYS A 436 7.965 -2.926 -10.214 1.00 98.65 C \\\\nATOM 3430 CB CYS A 436 8.944 -5.000 -9.249 1.00 98.65 C \\\\nATOM 3431 O CYS A 436 8.176 -2.221 -9.224 1.00 98.65 O \\\\nATOM 3432 SG CYS A 436 10.042 -6.419 -9.493 1.00 98.65 S \\\\nATOM 3433 N TRP A 437 6.930 -2.745 -11.023 1.00 98.76 N \\\\nATOM 3434 CA TRP A 437 5.951 -1.685 -10.817 1.00 98.76 C \\\\nATOM 3435 C TRP A 437 4.570 -2.099 -11.314 1.00 98.76 C \\\\nATOM 3436 CB TRP A 437 6.443 -0.390 -11.475 1.00 98.76 C \\\\nATOM 3437 O TRP A 437 4.419 -3.065 -12.058 1.00 98.76 O \\\\nATOM 3438 CG TRP A 437 6.614 -0.447 -12.954 1.00 98.76 C \\\\nATOM 3439 CD1 TRP A 437 7.657 -1.001 -13.607 1.00 98.76 C \\\\nATOM 3440 CD2 TRP A 437 5.717 0.067 -13.983 1.00 98.76 C \\\\nATOM 3441 CE2 TRP A 437 6.302 -0.203 -15.253 1.00 98.76 C \\\\nATOM 3442 CE3 TRP A 437 4.477 0.739 -13.970 1.00 98.76 C \\\\nATOM 3443 NE1 TRP A 437 7.475 -0.852 -14.960 1.00 98.76 N \\\\nATOM 3444 CH2 TRP A 437 4.433 0.768 -16.408 1.00 98.76 C \\\\nATOM 3445 CZ2 TRP A 437 5.676 0.125 -16.457 1.00 98.76 C \\\\nATOM 3446 CZ3 TRP A 437 3.846 1.096 -15.175 1.00 98.76 C \\\\nATOM 3447 N ILE A 438 3.554 -1.388 -10.843 1.00 98.75 N \\\\nATOM 3448 CA ILE A 438 2.160 -1.576 -11.224 1.00 98.75 C \\\\nATOM 3449 C ILE A 438 1.571 -0.277 -11.759 1.00 98.75 C \\\\nATOM 3450 CB ILE A 438 1.303 -2.146 -10.072 1.00 98.75 C \\\\nATOM 3451 O ILE A 438 1.939 0.818 -11.324 1.00 98.75 O \\\\nATOM 3452 CG1 ILE A 438 1.413 -1.301 -8.783 1.00 98.75 C \\\\nATOM 3453 CG2 ILE A 438 1.664 -3.623 -9.848 1.00 98.75 C \\\\nATOM 3454 CD1 ILE A 438 0.412 -1.684 -7.687 1.00 98.75 C \\\\nATOM 3455 N GLU A 439 0.626 -0.425 -12.674 1.00 98.66 N \\\\nATOM 3456 CA GLU A 439 -0.226 0.638 -13.185 1.00 98.66 C \\\\nATOM 3457 C GLU A 439 -1.659 0.385 -12.722 1.00 98.66 C \\\\nATOM 3458 CB GLU A 439 -0.113 0.684 -14.711 1.00 98.66 C \\\\nATOM 3459 O GLU A 439 -2.210 -0.693 -12.943 1.00 98.66 O \\\\nATOM 3460 CG GLU A 439 -0.773 1.930 -15.307 1.00 98.66 C \\\\nATOM 3461 CD GLU A 439 -0.329 2.117 -16.764 1.00 98.66 C \\\\nATOM 3462 OE1 GLU A 439 -0.586 1.190 -17.567 1.00 98.66 O \\\\nATOM 3463 OE2 GLU A 439 0.372 3.136 -17.029 1.00 98.66 O \\\\nATOM 3464 N LEU A 440 -2.231 1.368 -12.034 1.00 98.22 N \\\\nATOM 3465 CA LEU A 440 -3.578 1.347 -11.491 1.00 98.22 C \\\\nATOM 3466 C LEU A 440 -4.466 2.258 -12.334 1.00 98.22 C \\\\nATOM 3467 CB LEU A 440 -3.521 1.826 -10.023 1.00 98.22 C \\\\nATOM 3468 O LEU A 440 -4.170 3.444 -12.452 1.00 98.22 O \\\\nATOM 3469 CG LEU A 440 -4.725 1.370 -9.189 1.00 98.22 C \\\\nATOM 3470 CD1 LEU A 440 -4.507 -0.084 -8.800 1.00 98.22 C \\\\nATOM 3471 CD2 LEU A 440 -4.859 2.179 -7.899 1.00 98.22 C \\\\nATOM 3472 N HIS A 441 -5.560 1.729 -12.870 1.00 98.13 N \\\\nATOM 3473 CA HIS A 441 -6.609 2.516 -13.522 1.00 98.13 C \\\\nATOM 3474 C HIS A 441 -7.832 2.593 -12.619 1.00 98.13 C \\\\nATOM 3475 CB HIS A 441 -6.971 1.905 -14.878 1.00 98.13 C \\\\nATOM 3476 O HIS A 441 -8.337 1.558 -12.183 1.00 98.13 O \\\\nATOM 3477 CG HIS A 441 -5.885 1.987 -15.917 1.00 98.13 C \\\\nATOM 3478 CD2 HIS A 441 -4.763 2.768 -15.870 1.00 98.13 C \\\\nATOM 3479 ND1 HIS A 441 -5.880 1.348 -17.135 1.00 98.13 N \\\\nATOM 3480 CE1 HIS A 441 -4.779 1.739 -17.802 1.00 98.13 C \\\\nATOM 3481 NE2 HIS A 441 -4.070 2.613 -17.069 1.00 98.13 N \\\\nATOM 3482 N LEU A 442 -8.298 3.808 -12.333 1.00 97.65 N \\\\nATOM 3483 CA LEU A 442 -9.493 4.052 -11.528 1.00 97.65 C \\\\nATOM 3484 C LEU A 442 -10.723 4.098 -12.435 1.00 97.65 C \\\\nATOM 3485 CB LEU A 442 -9.317 5.340 -10.712 1.00 97.65 C \\\\nATOM 3486 O LEU A 442 -10.966 5.081 -13.135 1.00 97.65 O \\\\nATOM 3487 CG LEU A 442 -8.113 5.327 -9.756 1.00 97.65 C \\\\nATOM 3488 CD1 LEU A 442 -8.076 6.651 -9.009 1.00 97.65 C \\\\nATOM 3489 CD2 LEU A 442 -8.185 4.200 -8.722 1.00 97.65 C \\\\nATOM 3490 N ASN A 443 -11.505 3.022 -12.414 1.00 96.77 N \\\\nATOM 3491 CA ASN A 443 -12.575 2.797 -13.384 1.00 96.77 C \\\\nATOM 3492 C ASN A 443 -13.730 3.790 -13.230 1.00 96.77 C \\\\nATOM 3493 CB ASN A 443 -13.079 1.359 -13.224 1.00 96.77 C \\\\nATOM 3494 O ASN A 443 -14.340 4.164 -14.223 1.00 96.77 O \\\\nATOM 3495 CG ASN A 443 -12.053 0.308 -13.601 1.00 96.77 C \\\\nATOM 3496 ND2 ASN A 443 -12.176 -0.876 -13.059 1.00 96.77 N \\\\nATOM 3497 OD1 ASN A 443 -11.132 0.524 -14.365 1.00 96.77 O \\\\nATOM 3498 N GLY A 444 -14.029 4.226 -12.003 1.00 94.54 N \\\\nATOM 3499 CA GLY A 444 -15.098 5.191 -11.745 1.00 94.54 C \\\\nATOM 3500 C GLY A 444 -14.801 6.553 -12.378 1.00 94.54 C \\\\nATOM 3501 O GLY A 444 -15.563 7.000 -13.235 1.00 94.54 O \\\\nATOM 3502 N PRO A 445 -13.667 7.192 -12.030 1.00 95.57 N \\\\nATOM 3503 CA PRO A 445 -13.183 8.395 -12.703 1.00 95.57 C \\\\nATOM 3504 C PRO A 445 -13.102 8.266 -14.232 1.00 95.57 C \\\\nATOM 3505 CB PRO A 445 -11.812 8.667 -12.076 1.00 95.57 C \\\\nATOM 3506 O PRO A 445 -13.582 9.157 -14.930 1.00 95.57 O \\\\nATOM 3507 CG PRO A 445 -11.990 8.153 -10.650 1.00 95.57 C \\\\nATOM 3508 CD PRO A 445 -12.852 6.911 -10.854 1.00 95.57 C \\\\nATOM 3509 N LEU A 446 -12.584 7.146 -14.758 1.00 96.12 N \\\\nATOM 3510 CA LEU A 446 -12.530 6.893 -16.207 1.00 96.12 C \\\\nATOM 3511 C LEU A 446 -13.920 6.832 -16.847 1.00 96.12 C \\\\nATOM 3512 CB LEU A 446 -11.786 5.576 -16.497 1.00 96.12 C \\\\nATOM 3513 O LEU A 446 -14.143 7.458 -17.876 1.00 96.12 O \\\\nATOM 3514 CG LEU A 446 -10.261 5.663 -16.366 1.00 96.12 C \\\\nATOM 3515 CD1 LEU A 446 -9.644 4.269 -16.456 1.00 96.12 C \\\\nATOM 3516 CD2 LEU A 446 -9.629 6.538 -17.453 1.00 96.12 C \\\\nATOM 3517 N GLN A 447 -14.867 6.114 -16.239 1.00 93.99 N \\\\nATOM 3518 CA GLN A 447 -16.236 6.022 -16.746 1.00 93.99 C \\\\nATOM 3519 C GLN A 447 -16.928 7.388 -16.734 1.00 93.99 C \\\\nATOM 3520 CB GLN A 447 -17.025 5.007 -15.900 1.00 93.99 C \\\\nATOM 3521 O GLN A 447 -17.694 7.710 -17.641 1.00 93.99 O \\\\nATOM 3522 CG GLN A 447 -18.453 4.827 -16.434 1.00 93.99 C \\\\nATOM 3523 CD GLN A 447 -19.274 3.840 -15.619 1.00 93.99 C \\\\nATOM 3524 NE2 GLN A 447 -19.847 2.835 -16.240 1.00 93.99 N \\\\nATOM 3525 OE1 GLN A 447 -19.488 3.984 -14.428 1.00 93.99 O \\\\nATOM 3526 N TRP A 448 -16.685 8.201 -15.705 1.00 93.61 N \\\\nATOM 3527 CA TRP A 448 -17.250 9.544 -15.649 1.00 93.61 C \\\\nATOM 3528 C TRP A 448 -16.668 10.445 -16.736 1.00 93.61 C \\\\nATOM 3529 CB TRP A 448 -17.020 10.139 -14.266 1.00 93.61 C \\\\nATOM 3530 O TRP A 448 -17.416 11.158 -17.403 1.00 93.61 O \\\\nATOM 3531 CG TRP A 448 -17.873 11.319 -13.917 1.00 93.61 C \\\\nATOM 3532 CD1 TRP A 448 -18.899 11.839 -14.637 1.00 93.61 C \\\\nATOM 3533 CD2 TRP A 448 -17.793 12.127 -12.714 1.00 93.61 C \\\\nATOM 3534 CE2 TRP A 448 -18.872 13.057 -12.721 1.00 93.61 C \\\\nATOM 3535 CE3 TRP A 448 -16.926 12.138 -11.604 1.00 93.61 C \\\\nATOM 3536 NE1 TRP A 448 -19.496 12.864 -13.931 1.00 93.61 N \\\\nATOM 3537 CH2 TRP A 448 -18.250 13.892 -10.548 1.00 93.61 C \\\\nATOM 3538 CZ2 TRP A 448 -19.116 13.916 -11.649 1.00 93.61 C \\\\nATOM 3539 CZ3 TRP A 448 -17.154 13.009 -10.530 1.00 93.61 C \\\\nATOM 3540 N LEU A 449 -15.354 10.358 -16.948 1.00 94.28 N \\\\nATOM 3541 CA LEU A 449 -14.655 11.076 -18.003 1.00 94.28 C \\\\nATOM 3542 C LEU A 449 -15.173 10.695 -19.397 1.00 94.28 C \\\\nATOM 3543 CB LEU A 449 -13.153 10.779 -17.862 1.00 94.28 C \\\\nATOM 3544 O LEU A 449 -15.466 11.579 -20.195 1.00 94.28 O \\\\nATOM 3545 CG LEU A 449 -12.289 11.610 -18.815 1.00 94.28 C \\\\nATOM 3546 CD1 LEU A 449 -12.347 13.079 -18.418 1.00 94.28 C \\\\nATOM 3547 CD2 LEU A 449 -10.841 11.143 -18.742 1.00 94.28 C \\\\nATOM 3548 N ASP A 450 -15.347 9.401 -19.664 1.00 92.60 N \\\\nATOM 3549 CA ASP A 450 -15.885 8.874 -20.924 1.00 92.60 C \\\\nATOM 3550 C ASP A 450 -17.291 9.424 -21.227 1.00 92.60 C \\\\nATOM 3551 CB ASP A 450 -15.886 7.343 -20.822 1.00 92.60 C \\\\nATOM 3552 O ASP A 450 -17.558 9.945 -22.313 1.00 92.60 O \\\\nATOM 3553 CG ASP A 450 -16.420 6.688 -22.093 1.00 92.60 C \\\\nATOM 3554 OD1 ASP A 450 -15.698 6.749 -23.110 1.00 92.60 O \\\\nATOM 3555 OD2 ASP A 450 -17.537 6.128 -22.015 1.00 92.60 O \\\\nATOM 3556 N LYS A 451 -18.181 9.440 -20.225 1.00 91.83 N \\\\nATOM 3557 CA LYS A 451 -19.519 10.041 -20.363 1.00 91.83 C \\\\nATOM 3558 C LYS A 451 -19.490 11.549 -20.640 1.00 91.83 C \\\\nATOM 3559 CB LYS A 451 -20.346 9.800 -19.104 1.00 91.83 C \\\\nATOM 3560 O LYS A 451 -20.411 12.062 -21.264 1.00 91.83 O \\\\nATOM 3561 CG LYS A 451 -20.774 8.346 -18.886 1.00 91.83 C \\\\nATOM 3562 CD LYS A 451 -21.546 8.299 -17.564 1.00 91.83 C \\\\nATOM 3563 CE LYS A 451 -21.927 6.876 -17.167 1.00 91.83 C \\\\nATOM 3564 NZ LYS A 451 -22.588 6.894 -15.839 1.00 91.83 N \\\\nATOM 3565 N VAL A 452 -18.482 12.272 -20.151 1.00 91.75 N \\\\nATOM 3566 CA VAL A 452 -18.313 13.704 -20.452 1.00 91.75 C \\\\nATOM 3567 C VAL A 452 -17.764 13.886 -21.868 1.00 91.75 C \\\\nATOM 3568 CB VAL A 452 -17.432 14.393 -19.392 1.00 91.75 C \\\\nATOM 3569 O VAL A 452 -18.312 14.673 -22.635 1.00 91.75 O \\\\nATOM 3570 CG1 VAL A 452 -17.045 15.822 -19.781 1.00 91.75 C \\\\nATOM 3571 CG2 VAL A 452 -18.180 14.477 -18.054 1.00 91.75 C \\\\nATOM 3572 N LEU A 453 -16.729 13.131 -22.246 1.00 91.05 N \\\\nATOM 3573 CA LEU A 453 -16.115 13.199 -23.577 1.00 91.05 C \\\\nATOM 3574 C LEU A 453 -17.106 12.863 -24.695 1.00 91.05 C \\\\nATOM 3575 CB LEU A 453 -14.907 12.248 -23.633 1.00 91.05 C \\\\nATOM 3576 O LEU A 453 -17.135 13.558 -25.707 1.00 91.05 O \\\\nATOM 3577 CG LEU A 453 -13.657 12.782 -22.915 1.00 91.05 C \\\\nATOM 3578 CD1 LEU A 453 -12.607 11.677 -22.819 1.00 91.05 C \\\\nATOM 3579 CD2 LEU A 453 -13.034 13.964 -23.666 1.00 91.05 C \\\\nATOM 3580 N THR A 454 -17.974 11.870 -24.489 1.00 88.74 N \\\\nATOM 3581 CA THR A 454 -19.038 11.510 -25.446 1.00 88.74 C \\\\nATOM 3582 C THR A 454 -20.045 12.639 -25.704 1.00 88.74 C \\\\nATOM 3583 CB THR A 454 -19.797 10.249 -25.000 1.00 88.74 C \\\\nATOM 3584 O THR A 454 -20.705 12.629 -26.739 1.00 88.74 O \\\\nATOM 3585 CG2 THR A 454 -18.964 8.980 -25.160 1.00 88.74 C \\\\nATOM 3586 OG1 THR A 454 -20.152 10.317 -23.644 1.00 88.74 O \\\\nATOM 3587 N GLN A 455 -20.145 13.631 -24.811 1.00 86.80 N \\\\nATOM 3588 CA GLN A 455 -21.014 14.806 -24.960 1.00 86.80 C \\\\nATOM 3589 C GLN A 455 -20.277 16.044 -25.514 1.00 86.80 C \\\\nATOM 3590 CB GLN A 455 -21.657 15.128 -23.598 1.00 86.80 C \\\\nATOM 3591 O GLN A 455 -20.926 16.977 -25.978 1.00 86.80 O \\\\nATOM 3592 CG GLN A 455 -22.542 14.008 -23.028 1.00 86.80 C \\\\nATOM 3593 CD GLN A 455 -23.867 13.803 -23.755 1.00 86.80 C \\\\nATOM 3594 NE2 GLN A 455 -24.498 12.666 -23.561 1.00 86.80 N \\\\nATOM 3595 OE1 GLN A 455 -24.396 14.643 -24.464 1.00 86.80 O \\\\nATOM 3596 N MET A 456 -18.937 16.067 -25.489 1.00 83.78 N \\\\nATOM 3597 CA MET A 456 -18.105 17.230 -25.855 1.00 83.78 C \\\\nATOM 3598 C MET A 456 -17.816 17.361 -27.364 1.00 83.78 C \\\\nATOM 3599 CB MET A 456 -16.786 17.177 -25.059 1.00 83.78 C \\\\nATOM 3600 O MET A 456 -17.165 18.316 -27.781 1.00 83.78 O \\\\nATOM 3601 CG MET A 456 -16.946 17.591 -23.591 1.00 83.78 C \\\\nATOM 3602 SD MET A 456 -17.155 19.371 -23.298 1.00 83.78 S \\\\nATOM 3603 CE MET A 456 -15.520 20.010 -23.739 1.00 83.78 C \\\\nATOM 3604 N GLY A 457 -18.270 16.423 -28.200 1.00 82.72 N \\\\nATOM 3605 CA GLY A 457 -17.965 16.416 -29.636 1.00 82.72 C \\\\nATOM 3606 C GLY A 457 -16.554 15.898 -29.944 1.00 82.72 C \\\\nATOM 3607 O GLY A 457 -16.102 14.932 -29.336 1.00 82.72 O \\\\nATOM 3608 N SER A 458 -15.869 16.502 -30.919 1.00 82.57 N \\\\nATOM 3609 CA SER A 458 -14.536 16.088 -31.390 1.00 82.57 C \\\\nATOM 3610 C SER A 458 -13.502 17.216 -31.256 1.00 82.57 C \\\\nATOM 3611 CB SER A 458 -14.626 15.612 -32.849 1.00 82.57 C \\\\nATOM 3612 O SER A 458 -13.892 18.384 -31.189 1.00 82.57 O \\\\nATOM 3613 OG SER A 458 -14.997 16.664 -33.725 1.00 82.57 O \\\\nATOM 3614 N PRO A 459 -12.187 16.917 -31.300 1.00 83.95 N \\\\nATOM 3615 CA PRO A 459 -11.150 17.944 -31.404 1.00 83.95 C \\\\nATOM 3616 C PRO A 459 -11.398 18.912 -32.571 1.00 83.95 C \\\\nATOM 3617 CB PRO A 459 -9.830 17.189 -31.592 1.00 83.95 C \\\\nATOM 3618 O PRO A 459 -11.916 18.519 -33.619 1.00 83.95 O \\\\nATOM 3619 CG PRO A 459 -10.104 15.818 -30.980 1.00 83.95 C \\\\nATOM 3620 CD PRO A 459 -11.586 15.591 -31.267 1.00 83.95 C \\\\nATOM 3621 N SER A 460 -10.991 20.174 -32.407 1.00 82.81 N \\\\nATOM 3622 CA SER A 460 -11.108 21.203 -33.452 1.00 82.81 C \\\\nATOM 3623 C SER A 460 -10.191 20.929 -34.648 1.00 82.81 C \\\\nATOM 3624 CB SER A 460 -10.787 22.579 -32.856 1.00 82.81 C \\\\nATOM 3625 O SER A 460 -10.555 21.194 -35.795 1.00 82.81 O \\\\nATOM 3626 OG SER A 460 -9.520 22.558 -32.219 1.00 82.81 O \\\\nATOM 3627 N VAL A 461 -9.008 20.365 -34.391 1.00 84.86 N \\\\nATOM 3628 CA VAL A 461 -8.042 19.977 -35.421 1.00 84.86 C \\\\nATOM 3629 C VAL A 461 -8.386 18.581 -35.931 1.00 84.86 C \\\\nATOM 3630 CB VAL A 461 -6.596 20.052 -34.897 1.00 84.86 C \\\\nATOM 3631 O VAL A 461 -8.351 17.603 -35.184 1.00 84.86 O \\\\nATOM 3632 CG1 VAL A 461 -5.591 19.735 -36.012 1.00 84.86 C \\\\nATOM 3633 CG2 VAL A 461 -6.274 21.456 -34.364 1.00 84.86 C \\\\nATOM 3634 N ARG A 462 -8.705 18.476 -37.224 1.00 86.91 N \\\\nATOM 3635 CA ARG A 462 -8.912 17.178 -37.878 1.00 86.91 C \\\\nATOM 3636 C ARG A 462 -7.580 16.446 -38.015 1.00 86.91 C \\\\nATOM 3637 CB ARG A 462 -9.587 17.337 -39.247 1.00 86.91 C \\\\nATOM 3638 O ARG A 462 -6.581 17.039 -38.412 1.00 86.91 O \\\\nATOM 3639 CG ARG A 462 -11.013 17.890 -39.126 1.00 86.91 C \\\\nATOM 3640 CD ARG A 462 -11.684 17.905 -40.502 1.00 86.91 C \\\\nATOM 3641 NE ARG A 462 -13.033 18.495 -40.434 1.00 86.91 N \\\\nATOM 3642 NH1 ARG A 462 -13.544 18.318 -42.665 1.00 86.91 N \\\\nATOM 3643 NH2 ARG A 462 -15.020 19.234 -41.262 1.00 86.91 N \\\\nATOM 3644 CZ ARG A 462 -13.857 18.679 -41.451 1.00 86.91 C \\\\nATOM 3645 N CYS A 463 -7.589 15.148 -37.736 1.00 86.96 N \\\\nATOM 3646 CA CYS A 463 -6.437 14.287 -37.969 1.00 86.96 C \\\\nATOM 3647 C CYS A 463 -6.320 13.944 -39.464 1.00 86.96 C \\\\nATOM 3648 CB CYS A 463 -6.570 13.047 -37.079 1.00 86.96 C \\\\nATOM 3649 O CYS A 463 -7.328 13.671 -40.121 1.00 86.96 O \\\\nATOM 3650 SG CYS A 463 -4.996 12.153 -37.080 1.00 86.96 S \\\\nATOM 3651 N SER A 464 -5.099 13.967 -40.000 1.00 88.07 N \\\\nATOM 3652 CA SER A 464 -4.820 13.510 -41.363 1.00 88.07 C \\\\nATOM 3653 C SER A 464 -4.835 11.983 -41.414 1.00 88.07 C \\\\nATOM 3654 CB SER A 464 -3.461 14.040 -41.824 1.00 88.07 C \\\\nATOM 3655 O SER A 464 -4.310 11.321 -40.526 1.00 88.07 O \\\\nATOM 3656 OG SER A 464 -3.099 13.502 -43.084 1.00 88.07 O \\\\nATOM 3657 N SER A 465 -5.379 11.407 -42.485 1.00 91.00 N \\\\nATOM 3658 CA SER A 465 -5.290 9.965 -42.748 1.00 91.00 C \\\\nATOM 3659 C SER A 465 -3.976 9.551 -43.433 1.00 91.00 C \\\\nATOM 3660 CB SER A 465 -6.508 9.521 -43.561 1.00 91.00 C \\\\nATOM 3661 O SER A 465 -3.864 8.409 -43.870 1.00 91.00 O \\\\nATOM 3662 OG SER A 465 -6.528 10.173 -44.818 1.00 91.00 O \\\\nATOM 3663 N MET A 466 -3.021 10.477 -43.604 1.00 85.74 N \\\\nATOM 3664 CA MET A 466 -1.770 10.264 -44.353 1.00 85.74 C \\\\nATOM 3665 C MET A 466 -0.494 10.702 -43.614 1.00 85.74 C \\\\nATOM 3666 CB MET A 466 -1.822 11.027 -45.692 1.00 85.74 C \\\\nATOM 3667 O MET A 466 0.590 10.472 -44.144 1.00 85.74 O \\\\nATOM 3668 CG MET A 466 -2.996 10.644 -46.597 1.00 85.74 C \\\\nATOM 3669 SD MET A 466 -2.952 11.423 -48.240 1.00 85.74 S \\\\nATOM 3670 CE MET A 466 -1.732 10.371 -49.073 1.00 85.74 C \\\\nATOM 3671 N SER A 467 -0.609 11.397 -42.475 1.00 72.38 N \\\\nATOM 3672 CA SER A 467 0.539 11.969 -41.746 1.00 72.38 C \\\\nATOM 3673 C SER A 467 1.298 10.949 -40.918 1.00 72.38 C \\\\nATOM 3674 CB SER A 467 0.108 13.100 -40.821 1.00 72.38 C \\\\nATOM 3675 O SER A 467 0.599 10.142 -40.264 1.00 72.38 O \\\\nATOM 3676 OG SER A 467 -0.858 12.568 -39.944 1.00 72.38 O \\\\nATOM 3677 OXT SER A 467 2.532 11.126 -40.865 1.00 72.38 O \\\\nTER 3678 SER A 467 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 9, 'score': 0}, {'residue_no': 10, 'score': 0}, {'residue_no': 11, 'score': 0}, {'residue_no': 12, 'score': 0}, {'residue_no': 13, 'score': 0}, {'residue_no': 14, 'score': 0}, {'residue_no': 15, 'score': 0}, {'residue_no': 16, 'score': 0}, {'residue_no': 17, 'score': 0}, {'residue_no': 18, 'score': 0}, {'residue_no': 19, 'score': 0}, {'residue_no': 20, 'score': 0}, {'residue_no': 21, 'score': 0}, {'residue_no': 22, 'score': 0}, {'residue_no': 23, 'score': 0}, {'residue_no': 24, 'score': 0}, {'residue_no': 25, 'score': 0}, {'residue_no': 26, 'score': 0}, {'residue_no': 27, 'score': 0}, {'residue_no': 28, 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{'residue_no': 419, 'score': 0.2302}, {'residue_no': 420, 'score': 0.2175}, {'residue_no': 421, 'score': 0.2119}, {'residue_no': 422, 'score': 0.2108}, {'residue_no': 423, 'score': 0.2133}, {'residue_no': 424, 'score': 0.2155}, {'residue_no': 425, 'score': 0.2078}], 'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 3 (P84022) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 425 UNP P84022 SMAD3_HUMAN 1 425 \\\\nSEQRES 1 A 425 MET SER SER ILE LEU PRO PHE THR PRO PRO ILE VAL LYS \\\\nSEQRES 2 A 425 ARG LEU LEU GLY TRP LYS LYS GLY GLU GLN ASN GLY GLN \\\\nSEQRES 3 A 425 GLU GLU LYS TRP CYS GLU LYS ALA VAL LYS SER LEU VAL \\\\nSEQRES 4 A 425 LYS LYS LEU LYS LYS THR GLY GLN LEU ASP GLU LEU GLU \\\\nSEQRES 5 A 425 LYS ALA ILE THR THR GLN ASN VAL ASN THR LYS CYS ILE \\\\nSEQRES 6 A 425 THR ILE PRO ARG SER LEU ASP GLY ARG LEU GLN VAL SER \\\\nSEQRES 7 A 425 HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG LEU \\\\nSEQRES 8 A 425 TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU ARG \\\\nSEQRES 9 A 425 ALA MET GLU LEU CYS GLU PHE ALA PHE ASN MET LYS LYS \\\\nSEQRES 10 A 425 ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG VAL \\\\nSEQRES 11 A 425 GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG HIS \\\\nSEQRES 12 A 425 THR GLU ILE PRO ALA GLU PHE PRO PRO LEU ASP ASP TYR \\\\nSEQRES 13 A 425 SER HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA GLY \\\\nSEQRES 14 A 425 ILE GLU PRO GLN SER ASN ILE PRO GLU THR PRO PRO PRO \\\\nSEQRES 15 A 425 GLY TYR LEU SER GLU ASP GLY GLU THR SER ASP HIS GLN \\\\nSEQRES 16 A 425 MET ASN HIS SER MET ASP ALA GLY SER PRO ASN LEU SER \\\\nSEQRES 17 A 425 PRO ASN PRO MET SER PRO ALA HIS ASN ASN LEU ASP LEU \\\\nSEQRES 18 A 425 GLN PRO VAL THR TYR CYS GLU PRO ALA PHE TRP CYS SER \\\\nSEQRES 19 A 425 ILE SER TYR TYR GLU LEU ASN GLN ARG VAL GLY GLU THR \\\\nSEQRES 20 A 425 PHE HIS ALA SER GLN PRO SER MET THR VAL ASP GLY PHE \\\\nSEQRES 21 A 425 THR ASP PRO SER ASN SER GLU ARG PHE CYS LEU GLY LEU \\\\nSEQRES 22 A 425 LEU SER ASN VAL ASN ARG ASN ALA ALA VAL GLU LEU THR \\\\nSEQRES 23 A 425 ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU TYR TYR ILE \\\\nSEQRES 24 A 425 GLY GLY GLU VAL PHE ALA GLU CYS LEU SER ASP SER ALA \\\\nSEQRES 25 A 425 ILE PHE VAL GLN SER PRO ASN CYS ASN GLN ARG TYR GLY \\\\nSEQRES 26 A 425 TRP HIS PRO ALA THR VAL CYS LYS ILE PRO PRO GLY CYS \\\\nSEQRES 27 A 425 ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE ALA ALA LEU \\\\nSEQRES 28 A 425 LEU ALA GLN SER VAL ASN GLN GLY PHE GLU ALA VAL TYR \\\\nSEQRES 29 A 425 GLN LEU THR ARG MET CYS THR ILE ARG MET SER PHE VAL \\\\nSEQRES 30 A 425 LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN THR VAL THR \\\\nSEQRES 31 A 425 SER THR PRO CYS TRP ILE GLU LEU HIS LEU ASN GLY PRO \\\\nSEQRES 32 A 425 LEU GLN TRP LEU ASP LYS VAL LEU THR GLN MET GLY SER \\\\nSEQRES 33 A 425 PRO SER ILE ARG CYS SER SER VAL SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 4.273 0.848 52.113 1.00 39.24 N \\\\nATOM 2 CA MET A 1 3.232 1.902 52.065 1.00 39.24 C \\\\nATOM 3 C MET A 1 2.383 1.673 50.826 1.00 39.24 C \\\\nATOM 4 CB MET A 1 3.847 3.308 52.057 1.00 39.24 C \\\\nATOM 5 O MET A 1 2.942 1.318 49.796 1.00 39.24 O \\\\nATOM 6 CG MET A 1 4.474 3.642 53.416 1.00 39.24 C \\\\nATOM 7 SD MET A 1 5.360 5.216 53.426 1.00 39.24 S \\\\nATOM 8 CE MET A 1 5.935 5.252 55.146 1.00 39.24 C \\\\nATOM 9 N SER A 2 1.062 1.771 50.948 1.00 36.12 N \\\\nATOM 10 CA SER A 2 0.109 1.246 49.960 1.00 36.12 C \\\\nATOM 11 C SER A 2 0.079 2.048 48.655 1.00 36.12 C \\\\nATOM 12 CB SER A 2 -1.295 1.213 50.580 1.00 36.12 C \\\\nATOM 13 O SER A 2 -0.137 3.258 48.672 1.00 36.12 O \\\\nATOM 14 OG SER A 2 -1.227 0.650 51.880 1.00 36.12 O \\\\nATOM 15 N SER A 3 0.231 1.370 47.514 1.00 38.89 N \\\\nATOM 16 CA SER A 3 0.023 1.960 46.189 1.00 38.89 C \\\\nATOM 17 C SER A 3 -1.462 2.235 45.957 1.00 38.89 C \\\\nATOM 18 CB SER A 3 0.557 1.029 45.093 1.00 38.89 C \\\\nATOM 19 O SER A 3 -2.252 1.303 45.792 1.00 38.89 O \\\\nATOM 20 OG SER A 3 -0.053 -0.245 45.163 1.00 38.89 O \\\\nATOM 21 N ILE A 4 -1.855 3.506 45.916 1.00 47.07 N \\\\nATOM 22 CA ILE A 4 -3.232 3.888 45.596 1.00 47.07 C \\\\nATOM 23 C ILE A 4 -3.496 3.548 44.123 1.00 47.07 C \\\\nATOM 24 CB ILE A 4 -3.468 5.379 45.927 1.00 47.07 C \\\\nATOM 25 O ILE A 4 -2.938 4.179 43.224 1.00 47.07 O \\\\nATOM 26 CG1 ILE A 4 -3.261 5.625 47.443 1.00 47.07 C \\\\nATOM 27 CG2 ILE A 4 -4.879 5.821 45.493 1.00 47.07 C \\\\nATOM 28 CD1 ILE A 4 -3.274 7.105 47.845 1.00 47.07 C \\\\nATOM 29 N LEU A 5 -4.344 2.546 43.868 1.00 53.20 N \\\\nATOM 30 CA LEU A 5 -4.810 2.232 42.516 1.00 53.20 C \\\\nATOM 31 C LEU A 5 -5.549 3.457 41.941 1.00 53.20 C \\\\nATOM 32 CB LEU A 5 -5.721 0.989 42.534 1.00 53.20 C \\\\nATOM 33 O LEU A 5 -6.408 4.021 42.625 1.00 53.20 O \\\\nATOM 34 CG LEU A 5 -4.992 -0.340 42.812 1.00 53.20 C \\\\nATOM 35 CD1 LEU A 5 -6.017 -1.450 43.037 1.00 53.20 C \\\\nATOM 36 CD2 LEU A 5 -4.094 -0.756 41.643 1.00 53.20 C \\\\nATOM 37 N PRO A 6 -5.246 3.897 40.705 1.00 60.37 N \\\\nATOM 38 CA PRO A 6 -5.812 5.125 40.159 1.00 60.37 C \\\\nATOM 39 C PRO A 6 -7.330 4.999 39.986 1.00 60.37 C \\\\nATOM 40 CB PRO A 6 -5.074 5.367 38.837 1.00 60.37 C \\\\nATOM 41 O PRO A 6 -7.816 4.186 39.200 1.00 60.37 O \\\\nATOM 42 CG PRO A 6 -4.604 3.971 38.422 1.00 60.37 C \\\\nATOM 43 CD PRO A 6 -4.319 3.294 39.760 1.00 60.37 C \\\\nATOM 44 N PHE A 7 -8.088 5.832 40.702 1.00 70.62 N \\\\nATOM 45 CA PHE A 7 -9.549 5.804 40.675 1.00 70.62 C \\\\nATOM 46 C PHE A 7 -10.094 6.178 39.288 1.00 70.62 C \\\\nATOM 47 CB PHE A 7 -10.103 6.723 41.773 1.00 70.62 C \\\\nATOM 48 O PHE A 7 -10.023 7.331 38.853 1.00 70.62 O \\\\nATOM 49 CG PHE A 7 -11.618 6.706 41.884 1.00 70.62 C \\\\nATOM 50 CD1 PHE A 7 -12.391 7.683 41.227 1.00 70.62 C \\\\nATOM 51 CD2 PHE A 7 -12.256 5.721 42.662 1.00 70.62 C \\\\nATOM 52 CE1 PHE A 7 -13.792 7.682 41.356 1.00 70.62 C \\\\nATOM 53 CE2 PHE A 7 -13.657 5.718 42.788 1.00 70.62 C \\\\nATOM 54 CZ PHE A 7 -14.425 6.699 42.137 1.00 70.62 C \\\\nATOM 55 N THR A 8 -10.670 5.201 38.590 1.00 75.98 N \\\\nATOM 56 CA THR A 8 -11.340 5.419 37.302 1.00 75.98 C \\\\nATOM 57 C THR A 8 -12.798 5.827 37.530 1.00 75.98 C \\\\nATOM 58 CB THR A 8 -11.204 4.193 36.395 1.00 75.98 C \\\\nATOM 59 O THR A 8 -13.551 5.029 38.095 1.00 75.98 O \\\\nATOM 60 CG2 THR A 8 -11.939 4.349 35.065 1.00 75.98 C \\\\nATOM 61 OG1 THR A 8 -9.832 4.107 36.111 1.00 75.98 O \\\\nATOM 62 N PRO A 9 -13.225 7.032 37.086 1.00 83.88 N \\\\nATOM 63 CA PRO A 9 -14.572 7.540 37.343 1.00 83.88 C \\\\nATOM 64 C PRO A 9 -15.673 6.578 36.863 1.00 83.88 C \\\\nATOM 65 CB PRO A 9 -14.661 8.884 36.610 1.00 83.88 C \\\\nATOM 66 O PRO A 9 -15.524 6.006 35.780 1.00 83.88 O \\\\nATOM 67 CG PRO A 9 -13.212 9.362 36.576 1.00 83.88 C \\\\nATOM 68 CD PRO A 9 -12.428 8.062 36.428 1.00 83.88 C \\\\nATOM 69 N PRO A 10 -16.809 6.445 37.578 1.00 90.89 N \\\\nATOM 70 CA PRO A 10 -17.865 5.488 37.225 1.00 90.89 C \\\\nATOM 71 C PRO A 10 -18.361 5.599 35.776 1.00 90.89 C \\\\nATOM 72 CB PRO A 10 -18.993 5.742 38.231 1.00 90.89 C \\\\nATOM 73 O PRO A 10 -18.535 4.588 35.102 1.00 90.89 O \\\\nATOM 74 CG PRO A 10 -18.247 6.237 39.468 1.00 90.89 C \\\\nATOM 75 CD PRO A 10 -17.097 7.049 38.875 1.00 90.89 C \\\\nATOM 76 N ILE A 11 -18.503 6.820 35.248 1.00 92.27 N \\\\nATOM 77 CA ILE A 11 -18.903 7.038 33.849 1.00 92.27 C \\\\nATOM 78 C ILE A 11 -17.867 6.545 32.827 1.00 92.27 C \\\\nATOM 79 CB ILE A 11 -19.300 8.510 33.624 1.00 92.27 C \\\\nATOM 80 O ILE A 11 -18.248 6.053 31.772 1.00 92.27 O \\\\nATOM 81 CG1 ILE A 11 -19.974 8.665 32.243 1.00 92.27 C \\\\nATOM 82 CG2 ILE A 11 -18.109 9.479 33.789 1.00 92.27 C \\\\nATOM 83 CD1 ILE A 11 -20.932 9.855 32.186 1.00 92.27 C \\\\nATOM 84 N VAL A 12 -16.570 6.592 33.149 1.00 93.66 N \\\\nATOM 85 CA VAL A 12 -15.523 6.020 32.287 1.00 93.66 C \\\\nATOM 86 C VAL A 12 -15.661 4.498 32.246 1.00 93.66 C \\\\nATOM 87 CB VAL A 12 -14.116 6.446 32.749 1.00 93.66 C \\\\nATOM 88 O VAL A 12 -15.583 3.927 31.165 1.00 93.66 O \\\\nATOM 89 CG1 VAL A 12 -12.997 5.748 31.970 1.00 93.66 C \\\\nATOM 90 CG2 VAL A 12 -13.919 7.961 32.599 1.00 93.66 C \\\\nATOM 91 N LYS A 13 -15.937 3.848 33.388 1.00 92.88 N \\\\nATOM 92 CA LYS A 13 -16.201 2.399 33.430 1.00 92.88 C \\\\nATOM 93 C LYS A 13 -17.434 2.024 32.600 1.00 92.88 C \\\\nATOM 94 CB LYS A 13 -16.346 1.887 34.873 1.00 92.88 C \\\\nATOM 95 O LYS A 13 -17.344 1.111 31.788 1.00 92.88 O \\\\nATOM 96 CG LYS A 13 -15.076 2.061 35.721 1.00 92.88 C \\\\nATOM 97 CD LYS A 13 -15.226 1.310 37.053 1.00 92.88 C \\\\nATOM 98 CE LYS A 13 -13.955 1.424 37.902 1.00 92.88 C \\\\nATOM 99 NZ LYS A 13 -14.041 0.572 39.118 1.00 92.88 N \\\\nATOM 100 N ARG A 14 -18.548 2.762 32.738 1.00 93.78 N \\\\nATOM 101 CA ARG A 14 -19.767 2.548 31.930 1.00 93.78 C \\\\nATOM 102 C ARG A 14 -19.486 2.672 30.430 1.00 93.78 C \\\\nATOM 103 CB ARG A 14 -20.903 3.501 32.350 1.00 93.78 C \\\\nATOM 104 O ARG A 14 -19.812 1.762 29.681 1.00 93.78 O \\\\nATOM 105 CG ARG A 14 -21.494 3.160 33.730 1.00 93.78 C \\\\nATOM 106 CD ARG A 14 -22.747 3.992 34.049 1.00 93.78 C \\\\nATOM 107 NE ARG A 14 -22.461 5.438 34.153 1.00 93.78 N \\\\nATOM 108 NH1 ARG A 14 -24.649 6.160 34.141 1.00 93.78 N \\\\nATOM 109 NH2 ARG A 14 -23.035 7.644 34.071 1.00 93.78 N \\\\nATOM 110 CZ ARG A 14 -23.376 6.396 34.150 1.00 93.78 C \\\\nATOM 111 N LEU A 15 -18.822 3.747 29.998 1.00 95.91 N \\\\nATOM 112 CA LEU A 15 -18.482 3.969 28.586 1.00 95.91 C \\\\nATOM 113 C LEU A 15 -17.500 2.923 28.024 1.00 95.91 C \\\\nATOM 114 CB LEU A 15 -17.910 5.388 28.430 1.00 95.91 C \\\\nATOM 115 O LEU A 15 -17.610 2.564 26.853 1.00 95.91 O \\\\nATOM 116 CG LEU A 15 -18.943 6.527 28.539 1.00 95.91 C \\\\nATOM 117 CD1 LEU A 15 -18.201 7.866 28.557 1.00 95.91 C \\\\nATOM 118 CD2 LEU A 15 -19.925 6.546 27.366 1.00 95.91 C \\\\nATOM 119 N LEU A 16 -16.567 2.412 28.835 1.00 94.13 N \\\\nATOM 120 CA LEU A 16 -15.676 1.311 28.444 1.00 94.13 C \\\\nATOM 121 C LEU A 16 -16.401 -0.038 28.358 1.00 94.13 C \\\\nATOM 122 CB LEU A 16 -14.492 1.222 29.420 1.00 94.13 C \\\\nATOM 123 O LEU A 16 -16.011 -0.863 27.540 1.00 94.13 O \\\\nATOM 124 CG LEU A 16 -13.472 2.357 29.249 1.00 94.13 C \\\\nATOM 125 CD1 LEU A 16 -12.531 2.383 30.449 1.00 94.13 C \\\\nATOM 126 CD2 LEU A 16 -12.618 2.203 27.986 1.00 94.13 C \\\\nATOM 127 N GLY A 17 -17.481 -0.245 29.117 1.00 93.26 N \\\\nATOM 128 CA GLY A 17 -18.336 -1.435 29.003 1.00 93.26 C \\\\nATOM 129 C GLY A 17 -19.018 -1.590 27.636 1.00 93.26 C \\\\nATOM 130 O GLY A 17 -19.403 -2.694 27.270 1.00 93.26 O \\\\nATOM 131 N TRP A 18 -19.112 -0.509 26.853 1.00 94.37 N \\\\nATOM 132 CA TRP A 18 -19.606 -0.526 25.470 1.00 94.37 C \\\\nATOM 133 C TRP A 18 -18.494 -0.673 24.414 1.00 94.37 C \\\\nATOM 134 CB TRP A 18 -20.455 0.728 25.232 1.00 94.37 C \\\\nATOM 135 O TRP A 18 -18.788 -0.656 23.216 1.00 94.37 O \\\\nATOM 136 CG TRP A 18 -21.736 0.776 26.007 1.00 94.37 C \\\\nATOM 137 CD1 TRP A 18 -21.931 1.414 27.182 1.00 94.37 C \\\\nATOM 138 CD2 TRP A 18 -23.021 0.170 25.667 1.00 94.37 C \\\\nATOM 139 CE2 TRP A 18 -23.955 0.477 26.701 1.00 94.37 C \\\\nATOM 140 CE3 TRP A 18 -23.489 -0.612 24.590 1.00 94.37 C \\\\nATOM 141 NE1 TRP A 18 -23.237 1.240 27.597 1.00 94.37 N \\\\nATOM 142 CH2 TRP A 18 -25.718 -0.746 25.586 1.00 94.37 C \\\\nATOM 143 CZ2 TRP A 18 -25.283 0.029 26.674 1.00 94.37 C \\\\nATOM 144 CZ3 TRP A 18 -24.821 -1.071 24.553 1.00 94.37 C \\\\nATOM 145 N LYS A 19 -17.220 -0.789 24.822 1.00 93.60 N \\\\nATOM 146 CA LYS A 19 -16.084 -0.967 23.904 1.00 93.60 C \\\\nATOM 147 C LYS A 19 -16.252 -2.261 23.100 1.00 93.60 C \\\\nATOM 148 CB LYS A 19 -14.760 -0.988 24.693 1.00 93.60 C \\\\nATOM 149 O LYS A 19 -16.579 -3.304 23.660 1.00 93.60 O \\\\nATOM 150 CG LYS A 19 -13.503 -0.930 23.802 1.00 93.60 C \\\\nATOM 151 CD LYS A 19 -12.226 -1.437 24.497 1.00 93.60 C \\\\nATOM 152 CE LYS A 19 -12.183 -2.968 24.676 1.00 93.60 C \\\\nATOM 153 NZ LYS A 19 -11.800 -3.697 23.436 1.00 93.60 N \\\\nATOM 154 N LYS A 20 -15.966 -2.216 21.800 1.00 91.32 N \\\\nATOM 155 CA LYS A 20 -15.914 -3.401 20.929 1.00 91.32 C \\\\nATOM 156 C LYS A 20 -14.490 -3.979 20.863 1.00 91.32 C \\\\nATOM 157 CB LYS A 20 -16.505 -3.040 19.552 1.00 91.32 C \\\\nATOM 158 O LYS A 20 -13.519 -3.312 21.226 1.00 91.32 O \\\\nATOM 159 CG LYS A 20 -17.955 -2.527 19.601 1.00 91.32 C \\\\nATOM 160 CD LYS A 20 -18.979 -3.550 20.111 1.00 91.32 C \\\\nATOM 161 CE LYS A 20 -20.374 -2.919 20.037 1.00 91.32 C \\\\nATOM 162 NZ LYS A 20 -21.437 -3.873 20.436 1.00 91.32 N \\\\nATOM 163 N GLY A 21 -14.358 -5.219 20.397 1.00 81.67 N \\\\nATOM 164 CA GLY A 21 -13.065 -5.891 20.200 1.00 81.67 C \\\\nATOM 165 C GLY A 21 -12.430 -6.446 21.479 1.00 81.67 C \\\\nATOM 166 O GLY A 21 -12.852 -6.136 22.595 1.00 81.67 O \\\\nATOM 167 N GLU A 22 -11.402 -7.268 21.296 1.00 73.16 N \\\\nATOM 168 CA GLU A 22 -10.807 -8.129 22.325 1.00 73.16 C \\\\nATOM 169 C GLU A 22 -10.076 -7.372 23.455 1.00 73.16 C \\\\nATOM 170 CB GLU A 22 -9.896 -9.162 21.638 1.00 73.16 C \\\\nATOM 171 O GLU A 22 -9.916 -6.143 23.435 1.00 73.16 O \\\\nATOM 172 CG GLU A 22 -10.687 -10.037 20.647 1.00 73.16 C \\\\nATOM 173 CD GLU A 22 -9.842 -11.154 20.025 1.00 73.16 C \\\\nATOM 174 OE1 GLU A 22 -10.462 -12.159 19.619 1.00 73.16 O \\\\nATOM 175 OE2 GLU A 22 -8.606 -10.975 19.959 1.00 73.16 O \\\\nATOM 176 N GLN A 23 -9.677 -8.115 24.493 1.00 63.69 N \\\\nATOM 177 CA GLN A 23 -9.051 -7.596 25.714 1.00 63.69 C \\\\nATOM 178 C GLN A 23 -7.518 -7.703 25.659 1.00 63.69 C \\\\nATOM 179 CB GLN A 23 -9.645 -8.273 26.962 1.00 63.69 C \\\\nATOM 180 O GLN A 23 -6.890 -8.444 26.413 1.00 63.69 O \\\\nATOM 181 CG GLN A 23 -11.129 -7.933 27.172 1.00 63.69 C \\\\nATOM 182 CD GLN A 23 -11.699 -8.529 28.459 1.00 63.69 C \\\\nATOM 183 NE2 GLN A 23 -13.005 -8.607 28.586 1.00 63.69 N \\\\nATOM 184 OE1 GLN A 23 -11.010 -8.940 29.374 1.00 63.69 O \\\\nATOM 185 N ASN A 24 -6.894 -6.916 24.782 1.00 71.71 N \\\\nATOM 186 CA ASN A 24 -5.439 -6.776 24.752 1.00 71.71 C \\\\nATOM 187 C ASN A 24 -4.978 -5.762 25.814 1.00 71.71 C \\\\nATOM 188 CB ASN A 24 -5.008 -6.406 23.321 1.00 71.71 C \\\\nATOM 189 O ASN A 24 -5.207 -4.560 25.680 1.00 71.71 O \\\\nATOM 190 CG ASN A 24 -5.145 -7.581 22.369 1.00 71.71 C \\\\nATOM 191 ND2 ASN A 24 -5.467 -7.332 21.123 1.00 71.71 N \\\\nATOM 192 OD1 ASN A 24 -4.943 -8.719 22.744 1.00 71.71 O \\\\nATOM 193 N GLY A 25 -4.286 -6.210 26.868 1.00 75.50 N \\\\nATOM 194 CA GLY A 25 -4.008 -5.386 28.061 1.00 75.50 C \\\\nATOM 195 C GLY A 25 -3.187 -4.097 27.844 1.00 75.50 C \\\\nATOM 196 O GLY A 25 -3.244 -3.176 28.665 1.00 75.50 O \\\\nATOM 197 N GLN A 26 -2.430 -3.977 26.746 1.00 77.51 N \\\\nATOM 198 CA GLN A 26 -1.778 -2.713 26.361 1.00 77.51 C \\\\nATOM 199 C GLN A 26 -2.749 -1.751 25.656 1.00 77.51 C \\\\nATOM 200 CB GLN A 26 -0.555 -3.004 25.477 1.00 77.51 C \\\\nATOM 201 O GLN A 26 -2.683 -0.536 25.861 1.00 77.51 O \\\\nATOM 202 CG GLN A 26 0.283 -1.736 25.216 1.00 77.51 C \\\\nATOM 203 CD GLN A 26 1.514 -1.993 24.352 1.00 77.51 C \\\\nATOM 204 NE2 GLN A 26 2.425 -1.051 24.240 1.00 77.51 N \\\\nATOM 205 OE1 GLN A 26 1.687 -3.027 23.745 1.00 77.51 O \\\\nATOM 206 N GLU A 27 -3.650 -2.291 24.839 1.00 83.83 N \\\\nATOM 207 CA GLU A 27 -4.675 -1.543 24.116 1.00 83.83 C \\\\nATOM 208 C GLU A 27 -5.765 -1.040 25.064 1.00 83.83 C \\\\nATOM 209 CB GLU A 27 -5.237 -2.448 23.019 1.00 83.83 C \\\\nATOM 210 O GLU A 27 -6.132 0.131 25.007 1.00 83.83 O \\\\nATOM 211 CG GLU A 27 -6.292 -1.739 22.170 1.00 83.83 C \\\\nATOM 212 CD GLU A 27 -6.606 -2.516 20.890 1.00 83.83 C \\\\nATOM 213 OE1 GLU A 27 -6.997 -1.820 19.927 1.00 83.83 O \\\\nATOM 214 OE2 GLU A 27 -6.412 -3.753 20.889 1.00 83.83 O \\\\nATOM 215 N GLU A 28 -6.189 -1.861 26.023 1.00 86.39 N \\\\nATOM 216 CA GLU A 28 -7.170 -1.496 27.046 1.00 86.39 C \\\\nATOM 217 C GLU A 28 -6.731 -0.262 27.858 1.00 86.39 C \\\\nATOM 218 CB GLU A 28 -7.381 -2.720 27.939 1.00 86.39 C \\\\nATOM 219 O GLU A 28 -7.491 0.700 28.008 1.00 86.39 O \\\\nATOM 220 CG GLU A 28 -8.544 -2.503 28.910 1.00 86.39 C \\\\nATOM 221 CD GLU A 28 -8.803 -3.737 29.776 1.00 86.39 C \\\\nATOM 222 OE1 GLU A 28 -9.988 -3.932 30.119 1.00 86.39 O \\\\nATOM 223 OE2 GLU A 28 -7.809 -4.416 30.120 1.00 86.39 O \\\\nATOM 224 N LYS A 29 -5.456 -0.210 28.275 1.00 89.47 N \\\\nATOM 225 CA LYS A 29 -4.847 0.972 28.919 1.00 89.47 C \\\\nATOM 226 C LYS A 29 -4.855 2.214 28.021 1.00 89.47 C \\\\nATOM 227 CB LYS A 29 -3.401 0.651 29.334 1.00 89.47 C \\\\nATOM 228 O LYS A 29 -4.849 3.338 28.529 1.00 89.47 O \\\\nATOM 229 CG LYS A 29 -3.332 -0.299 30.536 1.00 89.47 C \\\\nATOM 230 CD LYS A 29 -1.881 -0.697 30.847 1.00 89.47 C \\\\nATOM 231 CE LYS A 29 -1.878 -1.706 32.000 1.00 89.47 C \\\\nATOM 232 NZ LYS A 29 -0.524 -2.251 32.277 1.00 89.47 N \\\\nATOM 233 N TRP A 30 -4.836 2.050 26.699 1.00 92.08 N \\\\nATOM 234 CA TRP A 30 -4.953 3.163 25.757 1.00 92.08 C \\\\nATOM 235 C TRP A 30 -6.415 3.594 25.561 1.00 92.08 C \\\\nATOM 236 CB TRP A 30 -4.245 2.826 24.440 1.00 92.08 C \\\\nATOM 237 O TRP A 30 -6.694 4.792 25.632 1.00 92.08 O \\\\nATOM 238 CG TRP A 30 -4.246 3.969 23.477 1.00 92.08 C \\\\nATOM 239 CD1 TRP A 30 -3.329 4.961 23.418 1.00 92.08 C \\\\nATOM 240 CD2 TRP A 30 -5.266 4.301 22.489 1.00 92.08 C \\\\nATOM 241 CE2 TRP A 30 -4.898 5.529 21.862 1.00 92.08 C \\\\nATOM 242 CE3 TRP A 30 -6.468 3.691 22.071 1.00 92.08 C \\\\nATOM 243 NE1 TRP A 30 -3.720 5.898 22.481 1.00 92.08 N \\\\nATOM 244 CH2 TRP A 30 -6.859 5.472 20.450 1.00 92.08 C \\\\nATOM 245 CZ2 TRP A 30 -5.674 6.113 20.851 1.00 92.08 C \\\\nATOM 246 CZ3 TRP A 30 -7.259 4.273 21.064 1.00 92.08 C \\\\nATOM 247 N CYS A 31 -7.352 2.652 25.423 1.00 93.06 N \\\\nATOM 248 CA CYS A 31 -8.793 2.918 25.376 1.00 93.06 C \\\\nATOM 249 C CYS A 31 -9.267 3.664 26.631 1.00 93.06 C \\\\nATOM 250 CB CYS A 31 -9.547 1.589 25.225 1.00 93.06 C \\\\nATOM 251 O CYS A 31 -9.973 4.667 26.526 1.00 93.06 O \\\\nATOM 252 SG CYS A 31 -9.173 0.837 23.618 1.00 93.06 S \\\\nATOM 253 N GLU A 32 -8.811 3.253 27.818 1.00 93.85 N \\\\nATOM 254 CA GLU A 32 -9.129 3.942 29.068 1.00 93.85 C \\\\nATOM 255 C GLU A 32 -8.646 5.403 29.051 1.00 93.85 C \\\\nATOM 256 CB GLU A 32 -8.528 3.173 30.256 1.00 93.85 C \\\\nATOM 257 O GLU A 32 -9.396 6.315 29.410 1.00 93.85 O \\\\nATOM 258 CG GLU A 32 -9.135 3.703 31.560 1.00 93.85 C \\\\nATOM 259 CD GLU A 32 -8.376 3.311 32.819 1.00 93.85 C \\\\nATOM 260 OE1 GLU A 32 -9.063 3.201 33.856 1.00 93.85 O \\\\nATOM 261 OE2 GLU A 32 -7.156 3.567 32.892 1.00 93.85 O \\\\nATOM 262 N LYS A 33 -7.422 5.662 28.568 1.00 94.20 N \\\\nATOM 263 CA LYS A 33 -6.902 7.028 28.384 1.00 94.20 C \\\\nATOM 264 C LYS A 33 -7.714 7.822 27.350 1.00 94.20 C \\\\nATOM 265 CB LYS A 33 -5.416 6.983 27.997 1.00 94.20 C \\\\nATOM 266 O LYS A 33 -7.950 9.012 27.570 1.00 94.20 O \\\\nATOM 267 CG LYS A 33 -4.493 6.589 29.163 1.00 94.20 C \\\\nATOM 268 CD LYS A 33 -3.055 6.448 28.644 1.00 94.20 C \\\\nATOM 269 CE LYS A 33 -2.055 6.087 29.746 1.00 94.20 C \\\\nATOM 270 NZ LYS A 33 -0.678 5.970 29.197 1.00 94.20 N \\\\nATOM 271 N ALA A 34 -8.168 7.195 26.262 1.00 95.40 N \\\\nATOM 272 CA ALA A 34 -8.990 7.833 25.229 1.00 95.40 C \\\\nATOM 273 C ALA A 34 -10.354 8.286 25.776 1.00 95.40 C \\\\nATOM 274 CB ALA A 34 -9.158 6.870 24.043 1.00 95.40 C \\\\nATOM 275 O ALA A 34 -10.758 9.432 25.550 1.00 95.40 O \\\\nATOM 276 N VAL A 35 -11.025 7.426 26.551 1.00 96.53 N \\\\nATOM 277 CA VAL A 35 -12.314 7.731 27.196 1.00 96.53 C \\\\nATOM 278 C VAL A 35 -12.135 8.746 28.331 1.00 96.53 C \\\\nATOM 279 CB VAL A 35 -13.021 6.443 27.671 1.00 96.53 C \\\\nATOM 280 O VAL A 35 -12.880 9.723 28.382 1.00 96.53 O \\\\nATOM 281 CG1 VAL A 35 -14.354 6.736 28.371 1.00 96.53 C \\\\nATOM 282 CG2 VAL A 35 -13.342 5.528 26.481 1.00 96.53 C \\\\nATOM 283 N LYS A 36 -11.109 8.614 29.189 1.00 95.17 N \\\\nATOM 284 CA LYS A 36 -10.775 9.626 30.220 1.00 95.17 C \\\\nATOM 285 C LYS A 36 -10.539 11.013 29.600 1.00 95.17 C \\\\nATOM 286 CB LYS A 36 -9.550 9.177 31.053 1.00 95.17 C \\\\nATOM 287 O LYS A 36 -11.017 12.011 30.141 1.00 95.17 O \\\\nATOM 288 CG LYS A 36 -9.892 8.090 32.090 1.00 95.17 C \\\\nATOM 289 CD LYS A 36 -8.669 7.513 32.836 1.00 95.17 C \\\\nATOM 290 CE LYS A 36 -9.134 6.505 33.906 1.00 95.17 C \\\\nATOM 291 NZ LYS A 36 -8.036 5.721 34.536 1.00 95.17 N \\\\nATOM 292 N SER A 37 -9.846 11.077 28.460 1.00 94.09 N \\\\nATOM 293 CA SER A 37 -9.610 12.319 27.710 1.00 94.09 C \\\\nATOM 294 C SER A 37 -10.909 12.918 27.155 1.00 94.09 C \\\\nATOM 295 CB SER A 37 -8.606 12.064 26.581 1.00 94.09 C \\\\nATOM 296 O SER A 37 -11.152 14.114 27.340 1.00 94.09 O \\\\nATOM 297 OG SER A 37 -8.200 13.280 25.982 1.00 94.09 O \\\\nATOM 298 N LEU A 38 -11.783 12.096 26.554 1.00 96.68 N \\\\nATOM 299 CA LEU A 38 -13.076 12.562 26.040 1.00 96.68 C \\\\nATOM 300 C LEU A 38 -13.976 13.088 27.158 1.00 96.68 C \\\\nATOM 301 CB LEU A 38 -13.802 11.447 25.269 1.00 96.68 C \\\\nATOM 302 O LEU A 38 -14.448 14.217 27.080 1.00 96.68 O \\\\nATOM 303 CG LEU A 38 -15.076 11.947 24.555 1.00 96.68 C \\\\nATOM 304 CD1 LEU A 38 -14.806 13.050 23.532 1.00 96.68 C \\\\nATOM 305 CD2 LEU A 38 -15.755 10.790 23.841 1.00 96.68 C \\\\nATOM 306 N VAL A 39 -14.156 12.316 28.232 1.00 96.49 N \\\\nATOM 307 CA VAL A 39 -14.986 12.708 29.382 1.00 96.49 C \\\\nATOM 308 C VAL A 39 -14.498 14.033 29.979 1.00 96.49 C \\\\nATOM 309 CB VAL A 39 -15.018 11.573 30.428 1.00 96.49 C \\\\nATOM 310 O VAL A 39 -15.314 14.888 30.311 1.00 96.49 O \\\\nATOM 311 CG1 VAL A 39 -15.682 11.974 31.753 1.00 96.49 C \\\\nATOM 312 CG2 VAL A 39 -15.792 10.365 29.885 1.00 96.49 C \\\\nATOM 313 N LYS A 40 -13.179 14.271 30.054 1.00 94.22 N \\\\nATOM 314 CA LYS A 40 -12.625 15.559 30.512 1.00 94.22 C \\\\nATOM 315 C LYS A 40 -12.964 16.731 29.576 1.00 94.22 C \\\\nATOM 316 CB LYS A 40 -11.106 15.419 30.726 1.00 94.22 C \\\\nATOM 317 O LYS A 40 -13.098 17.851 30.064 1.00 94.22 O \\\\nATOM 318 CG LYS A 40 -10.491 16.668 31.386 1.00 94.22 C \\\\nATOM 319 CD LYS A 40 -8.990 16.506 31.663 1.00 94.22 C \\\\nATOM 320 CE LYS A 40 -8.447 17.779 32.331 1.00 94.22 C \\\\nATOM 321 NZ LYS A 40 -6.997 17.680 32.651 1.00 94.22 N \\\\nATOM 322 N LYS A 41 -13.090 16.499 28.263 1.00 94.36 N \\\\nATOM 323 CA LYS A 41 -13.530 17.509 27.283 1.00 94.36 C \\\\nATOM 324 C LYS A 41 -15.037 17.759 27.391 1.00 94.36 C \\\\nATOM 325 CB LYS A 41 -13.121 17.098 25.856 1.00 94.36 C \\\\nATOM 326 O LYS A 41 -15.428 18.897 27.622 1.00 94.36 O \\\\nATOM 327 CG LYS A 41 -11.608 17.217 25.604 1.00 94.36 C \\\\nATOM 328 CD LYS A 41 -11.234 16.547 24.272 1.00 94.36 C \\\\nATOM 329 CE LYS A 41 -9.768 16.770 23.874 1.00 94.36 C \\\\nATOM 330 NZ LYS A 41 -9.555 18.101 23.243 1.00 94.36 N \\\\nATOM 331 N LEU A 42 -15.862 16.712 27.337 1.00 96.39 N \\\\nATOM 332 CA LEU A 42 -17.328 16.840 27.334 1.00 96.39 C \\\\nATOM 333 C LEU A 42 -17.905 17.358 28.660 1.00 96.39 C \\\\nATOM 334 CB LEU A 42 -17.979 15.506 26.942 1.00 96.39 C \\\\nATOM 335 O LEU A 42 -18.942 18.012 28.663 1.00 96.39 O \\\\nATOM 336 CG LEU A 42 -17.544 14.942 25.578 1.00 96.39 C \\\\nATOM 337 CD1 LEU A 42 -18.333 13.665 25.325 1.00 96.39 C \\\\nATOM 338 CD2 LEU A 42 -17.753 15.890 24.400 1.00 96.39 C \\\\nATOM 339 N LYS A 43 -17.206 17.166 29.789 1.00 94.30 N \\\\nATOM 340 CA LYS A 43 -17.544 17.844 31.055 1.00 94.30 C \\\\nATOM 341 C LYS A 43 -17.469 19.373 30.981 1.00 94.30 C \\\\nATOM 342 CB LYS A 43 -16.642 17.354 32.200 1.00 94.30 C \\\\nATOM 343 O LYS A 43 -18.084 20.024 31.814 1.00 94.30 O \\\\nATOM 344 CG LYS A 43 -17.148 16.032 32.779 1.00 94.30 C \\\\nATOM 345 CD LYS A 43 -16.408 15.665 34.067 1.00 94.30 C \\\\nATOM 346 CE LYS A 43 -17.047 14.403 34.653 1.00 94.30 C \\\\nATOM 347 NZ LYS A 43 -16.722 14.247 36.092 1.00 94.30 N \\\\nATOM 348 N LYS A 44 -16.711 19.943 30.036 1.00 92.38 N \\\\nATOM 349 CA LYS A 44 -16.640 21.398 29.828 1.00 92.38 C \\\\nATOM 350 C LYS A 44 -17.732 21.922 28.893 1.00 92.38 C \\\\nATOM 351 CB LYS A 44 -15.269 21.811 29.280 1.00 92.38 C \\\\nATOM 352 O LYS A 44 -18.091 23.083 29.018 1.00 92.38 O \\\\nATOM 353 CG LYS A 44 -14.102 21.511 30.230 1.00 92.38 C \\\\nATOM 354 CD LYS A 44 -12.836 22.153 29.652 1.00 92.38 C \\\\nATOM 355 CE LYS A 44 -11.666 22.080 30.633 1.00 92.38 C \\\\nATOM 356 NZ LYS A 44 -10.614 23.058 30.251 1.00 92.38 N \\\\nATOM 357 N THR A 45 -18.227 21.093 27.971 1.00 92.89 N \\\\nATOM 358 CA THR A 45 -19.252 21.469 26.979 1.00 92.89 C \\\\nATOM 359 C THR A 45 -20.670 21.042 27.372 1.00 92.89 C \\\\nATOM 360 CB THR A 45 -18.919 20.901 25.588 1.00 92.89 C \\\\nATOM 361 O THR A 45 -21.625 21.418 26.705 1.00 92.89 O \\\\nATOM 362 CG2 THR A 45 -17.564 21.381 25.065 1.00 92.89 C \\\\nATOM 363 OG1 THR A 45 -18.867 19.493 25.628 1.00 92.89 O \\\\nATOM 364 N GLY A 46 -20.830 20.240 28.431 1.00 94.57 N \\\\nATOM 365 CA GLY A 46 -22.132 19.732 28.886 1.00 94.57 C \\\\nATOM 366 C GLY A 46 -22.679 18.545 28.078 1.00 94.57 C \\\\nATOM 367 O GLY A 46 -23.735 18.020 28.403 1.00 94.57 O \\\\nATOM 368 N GLN A 47 -21.958 18.059 27.064 1.00 96.14 N \\\\nATOM 369 CA GLN A 47 -22.416 16.991 26.154 1.00 96.14 C \\\\nATOM 370 C GLN A 47 -22.206 15.561 26.691 1.00 96.14 C \\\\nATOM 371 CB GLN A 47 -21.702 17.166 24.809 1.00 96.14 C \\\\nATOM 372 O GLN A 47 -22.330 14.589 25.945 1.00 96.14 O \\\\nATOM 373 CG GLN A 47 -22.141 18.419 24.037 1.00 96.14 C \\\\nATOM 374 CD GLN A 47 -21.126 18.755 22.955 1.00 96.14 C \\\\nATOM 375 NE2 GLN A 47 -21.521 18.931 21.715 1.00 96.14 N \\\\nATOM 376 OE1 GLN A 47 -19.939 18.835 23.226 1.00 96.14 O \\\\nATOM 377 N LEU A 48 -21.836 15.397 27.964 1.00 95.75 N \\\\nATOM 378 CA LEU A 48 -21.485 14.086 28.519 1.00 95.75 C \\\\nATOM 379 C LEU A 48 -22.686 13.127 28.579 1.00 95.75 C \\\\nATOM 380 CB LEU A 48 -20.831 14.306 29.891 1.00 95.75 C \\\\nATOM 381 O LEU A 48 -22.535 11.949 28.255 1.00 95.75 O \\\\nATOM 382 CG LEU A 48 -20.337 13.019 30.577 1.00 95.75 C \\\\nATOM 383 CD1 LEU A 48 -19.330 12.230 29.733 1.00 95.75 C \\\\nATOM 384 CD2 LEU A 48 -19.630 13.420 31.875 1.00 95.75 C \\\\nATOM 385 N ASP A 49 -23.866 13.642 28.922 1.00 95.20 N \\\\nATOM 386 CA ASP A 49 -25.095 12.846 29.016 1.00 95.20 C \\\\nATOM 387 C ASP A 49 -25.645 12.495 27.624 1.00 95.20 C \\\\nATOM 388 CB ASP A 49 -26.134 13.605 29.858 1.00 95.20 C \\\\nATOM 389 O ASP A 49 -26.134 11.388 27.407 1.00 95.20 O \\\\nATOM 390 CG ASP A 49 -25.631 13.965 31.265 1.00 95.20 C \\\\nATOM 391 OD1 ASP A 49 -24.765 13.233 31.800 1.00 95.20 O \\\\nATOM 392 OD2 ASP A 49 -26.072 15.015 31.774 1.00 95.20 O \\\\nATOM 393 N GLU A 50 -25.483 13.388 26.638 1.00 95.50 N \\\\nATOM 394 CA GLU A 50 -25.808 13.097 25.234 1.00 95.50 C \\\\nATOM 395 C GLU A 50 -24.863 12.031 24.649 1.00 95.50 C \\\\nATOM 396 CB GLU A 50 -25.787 14.382 24.385 1.00 95.50 C \\\\nATOM 397 O GLU A 50 -25.313 11.192 23.870 1.00 95.50 O \\\\nATOM 398 CG GLU A 50 -26.900 15.395 24.714 1.00 95.50 C \\\\nATOM 399 CD GLU A 50 -28.309 15.049 24.181 1.00 95.50 C \\\\nATOM 400 OE1 GLU A 50 -29.188 15.943 24.269 1.00 95.50 O \\\\nATOM 401 OE2 GLU A 50 -28.551 13.943 23.643 1.00 95.50 O \\\\nATOM 402 N LEU A 51 -23.579 11.987 25.051 1.00 96.84 N \\\\nATOM 403 CA LEU A 51 -22.690 10.876 24.681 1.00 96.84 C \\\\nATOM 404 C LEU A 51 -23.177 9.565 25.306 1.00 96.84 C \\\\nATOM 405 CB LEU A 51 -21.223 11.158 25.072 1.00 96.84 C \\\\nATOM 406 O LEU A 51 -23.258 8.559 24.608 1.00 96.84 O \\\\nATOM 407 CG LEU A 51 -20.286 9.951 24.816 1.00 96.84 C \\\\nATOM 408 CD1 LEU A 51 -20.083 9.664 23.326 1.00 96.84 C \\\\nATOM 409 CD2 LEU A 51 -18.912 10.170 25.444 1.00 96.84 C \\\\nATOM 410 N GLU A 52 -23.492 9.552 26.604 1.00 95.89 N \\\\nATOM 411 CA GLU A 52 -23.990 8.338 27.260 1.00 95.89 C \\\\nATOM 412 C GLU A 52 -25.289 7.842 26.603 1.00 95.89 C \\\\nATOM 413 CB GLU A 52 -24.130 8.559 28.777 1.00 95.89 C \\\\nATOM 414 O GLU A 52 -25.407 6.653 26.302 1.00 95.89 O \\\\nATOM 415 CG GLU A 52 -24.640 7.275 29.454 1.00 95.89 C \\\\nATOM 416 CD GLU A 52 -24.390 7.180 30.966 1.00 95.89 C \\\\nATOM 417 OE1 GLU A 52 -24.482 6.043 31.488 1.00 95.89 O \\\\nATOM 418 OE2 GLU A 52 -24.034 8.174 31.642 1.00 95.89 O \\\\nATOM 419 N LYS A 53 -26.214 8.750 26.274 1.00 96.28 N \\\\nATOM 420 CA LYS A 53 -27.424 8.464 25.493 1.00 96.28 C \\\\nATOM 421 C LYS A 53 -27.110 7.912 24.098 1.00 96.28 C \\\\nATOM 422 CB LYS A 53 -28.249 9.752 25.426 1.00 96.28 C \\\\nATOM 423 O LYS A 53 -27.704 6.910 23.710 1.00 96.28 O \\\\nATOM 424 CG LYS A 53 -29.588 9.592 24.694 1.00 96.28 C \\\\nATOM 425 CD LYS A 53 -30.278 10.958 24.673 1.00 96.28 C \\\\nATOM 426 CE LYS A 53 -31.551 10.955 23.829 1.00 96.28 C \\\\nATOM 427 NZ LYS A 53 -32.033 12.348 23.670 1.00 96.28 N \\\\nATOM 428 N ALA A 54 -26.183 8.509 23.347 1.00 96.62 N \\\\nATOM 429 CA ALA A 54 -25.789 8.024 22.020 1.00 96.62 C \\\\nATOM 430 C ALA A 54 -25.207 6.605 22.072 1.00 96.62 C \\\\nATOM 431 CB ALA A 54 -24.807 9.023 21.396 1.00 96.62 C \\\\nATOM 432 O ALA A 54 -25.616 5.742 21.298 1.00 96.62 O \\\\nATOM 433 N ILE A 55 -24.307 6.335 23.022 1.00 96.30 N \\\\nATOM 434 CA ILE A 55 -23.681 5.018 23.186 1.00 96.30 C \\\\nATOM 435 C ILE A 55 -24.688 3.949 23.637 1.00 96.30 C \\\\nATOM 436 CB ILE A 55 -22.447 5.125 24.110 1.00 96.30 C \\\\nATOM 437 O ILE A 55 -24.665 2.845 23.099 1.00 96.30 O \\\\nATOM 438 CG1 ILE A 55 -21.331 6.033 23.539 1.00 96.30 C \\\\nATOM 439 CG2 ILE A 55 -21.849 3.744 24.414 1.00 96.30 C \\\\nATOM 440 CD1 ILE A 55 -20.863 5.722 22.113 1.00 96.30 C \\\\nATOM 441 N THR A 56 -25.581 4.270 24.577 1.00 95.54 N \\\\nATOM 442 CA THR A 56 -26.559 3.307 25.119 1.00 95.54 C \\\\nATOM 443 C THR A 56 -27.722 3.023 24.169 1.00 95.54 C \\\\nATOM 444 CB THR A 56 -27.124 3.769 26.470 1.00 95.54 C \\\\nATOM 445 O THR A 56 -28.125 1.871 24.038 1.00 95.54 O \\\\nATOM 446 CG2 THR A 56 -26.083 3.724 27.588 1.00 95.54 C \\\\nATOM 447 OG1 THR A 56 -27.596 5.093 26.403 1.00 95.54 O \\\\nATOM 448 N THR A 57 -28.254 4.044 23.488 1.00 95.70 N \\\\nATOM 449 CA THR A 57 -29.405 3.891 22.573 1.00 95.70 C \\\\nATOM 450 C THR A 57 -29.015 3.477 21.157 1.00 95.70 C \\\\nATOM 451 CB THR A 57 -30.266 5.160 22.486 1.00 95.70 C \\\\nATOM 452 O THR A 57 -29.880 3.040 20.404 1.00 95.70 O \\\\nATOM 453 CG2 THR A 57 -30.814 5.604 23.842 1.00 95.70 C \\\\nATOM 454 OG1 THR A 57 -29.544 6.240 21.937 1.00 95.70 O \\\\nATOM 455 N GLN A 58 -27.740 3.634 20.781 1.00 94.54 N \\\\nATOM 456 CA GLN A 58 -27.207 3.349 19.440 1.00 94.54 C \\\\nATOM 457 C GLN A 58 -27.936 4.101 18.305 1.00 94.54 C \\\\nATOM 458 CB GLN A 58 -27.084 1.828 19.211 1.00 94.54 C \\\\nATOM 459 O GLN A 58 -27.935 3.680 17.149 1.00 94.54 O \\\\nATOM 460 CG GLN A 58 -26.407 1.116 20.396 1.00 94.54 C \\\\nATOM 461 CD GLN A 58 -26.008 -0.329 20.117 1.00 94.54 C \\\\nATOM 462 NE2 GLN A 58 -25.957 -1.152 21.140 1.00 94.54 N \\\\nATOM 463 OE1 GLN A 58 -25.721 -0.762 19.012 1.00 94.54 O \\\\nATOM 464 N ASN A 59 -28.581 5.224 18.639 1.00 92.87 N \\\\nATOM 465 CA ASN A 59 -29.505 5.929 17.759 1.00 92.87 C \\\\nATOM 466 C ASN A 59 -28.807 7.069 16.998 1.00 92.87 C \\\\nATOM 467 CB ASN A 59 -30.705 6.378 18.611 1.00 92.87 C \\\\nATOM 468 O ASN A 59 -28.278 8.009 17.602 1.00 92.87 O \\\\nATOM 469 CG ASN A 59 -31.841 7.012 17.826 1.00 92.87 C \\\\nATOM 470 ND2 ASN A 59 -32.980 7.188 18.452 1.00 92.87 N \\\\nATOM 471 OD1 ASN A 59 -31.741 7.366 16.661 1.00 92.87 O \\\\nATOM 472 N VAL A 60 -28.870 7.013 15.664 1.00 93.35 N \\\\nATOM 473 CA VAL A 60 -28.315 8.020 14.739 1.00 93.35 C \\\\nATOM 474 C VAL A 60 -28.921 9.418 14.934 1.00 93.35 C \\\\nATOM 475 CB VAL A 60 -28.468 7.567 13.270 1.00 93.35 C \\\\nATOM 476 O VAL A 60 -28.242 10.414 14.707 1.00 93.35 O \\\\nATOM 477 CG1 VAL A 60 -27.803 6.203 13.031 1.00 93.35 C \\\\nATOM 478 CG2 VAL A 60 -29.931 7.460 12.812 1.00 93.35 C \\\\nATOM 479 N ASN A 61 -30.156 9.502 15.441 1.00 95.00 N \\\\nATOM 480 CA ASN A 61 -30.888 10.750 15.696 1.00 95.00 C \\\\nATOM 481 C ASN A 61 -30.514 11.426 17.033 1.00 95.00 C \\\\nATOM 482 CB ASN A 61 -32.399 10.475 15.611 1.00 95.00 C \\\\nATOM 483 O ASN A 61 -31.206 12.332 17.498 1.00 95.00 O \\\\nATOM 484 CG ASN A 61 -32.808 9.842 14.297 1.00 95.00 C \\\\nATOM 485 ND2 ASN A 61 -33.213 8.595 14.305 1.00 95.00 N \\\\nATOM 486 OD1 ASN A 61 -32.733 10.444 13.246 1.00 95.00 O \\\\nATOM 487 N THR A 62 -29.454 10.970 17.706 1.00 95.86 N \\\\nATOM 488 CA THR A 62 -28.888 11.690 18.859 1.00 95.86 C \\\\nATOM 489 C THR A 62 -28.145 12.951 18.412 1.00 95.86 C \\\\nATOM 490 CB THR A 62 -28.010 10.785 19.738 1.00 95.86 C \\\\nATOM 491 O THR A 62 -27.816 13.104 17.239 1.00 95.86 O \\\\nATOM 492 CG2 THR A 62 -28.897 9.815 20.518 1.00 95.86 C \\\\nATOM 493 OG1 THR A 62 -27.070 10.038 18.995 1.00 95.86 O \\\\nATOM 494 N LYS A 63 -27.895 13.895 19.330 1.00 96.63 N \\\\nATOM 495 CA LYS A 63 -27.209 15.154 18.992 1.00 96.63 C \\\\nATOM 496 C LYS A 63 -25.744 14.921 18.605 1.00 96.63 C \\\\nATOM 497 CB LYS A 63 -27.314 16.159 20.148 1.00 96.63 C \\\\nATOM 498 O LYS A 63 -25.135 13.909 18.967 1.00 96.63 O \\\\nATOM 499 CG LYS A 63 -28.758 16.609 20.412 1.00 96.63 C \\\\nATOM 500 CD LYS A 63 -28.768 17.696 21.493 1.00 96.63 C \\\\nATOM 501 CE LYS A 63 -30.200 17.996 21.951 1.00 96.63 C \\\\nATOM 502 NZ LYS A 63 -30.233 18.277 23.405 1.00 96.63 N \\\\nATOM 503 N CYS A 64 -25.151 15.889 17.906 1.00 97.45 N \\\\nATOM 504 CA CYS A 64 -23.708 15.899 17.689 1.00 97.45 C \\\\nATOM 505 C CYS A 64 -22.976 16.013 19.035 1.00 97.45 C \\\\nATOM 506 CB CYS A 64 -23.301 17.032 16.736 1.00 97.45 C \\\\nATOM 507 O CYS A 64 -23.277 16.878 19.859 1.00 97.45 O \\\\nATOM 508 SG CYS A 64 -23.929 16.730 15.059 1.00 97.45 S \\\\nATOM 509 N ILE A 65 -21.986 15.145 19.238 1.00 97.88 N \\\\nATOM 510 CA ILE A 65 -21.057 15.214 20.369 1.00 97.88 C \\\\nATOM 511 C ILE A 65 -19.784 15.843 19.833 1.00 97.88 C \\\\nATOM 512 CB ILE A 65 -20.803 13.809 20.959 1.00 97.88 C \\\\nATOM 513 O ILE A 65 -19.086 15.193 19.059 1.00 97.88 O \\\\nATOM 514 CG1 ILE A 65 -22.099 13.076 21.362 1.00 97.88 C \\\\nATOM 515 CG2 ILE A 65 -19.845 13.902 22.156 1.00 97.88 C \\\\nATOM 516 CD1 ILE A 65 -23.002 13.838 22.332 1.00 97.88 C \\\\nATOM 517 N THR A 66 -19.495 17.093 20.178 1.00 97.50 N \\\\nATOM 518 CA THR A 66 -18.403 17.848 19.556 1.00 97.50 C \\\\nATOM 519 C THR A 66 -17.161 17.943 20.436 1.00 97.50 C \\\\nATOM 520 CB THR A 66 -18.853 19.226 19.043 1.00 97.50 C \\\\nATOM 521 O THR A 66 -17.208 17.860 21.663 1.00 97.50 O \\\\nATOM 522 CG2 THR A 66 -19.826 19.092 17.873 1.00 97.50 C \\\\nATOM 523 OG1 THR A 66 -19.484 20.007 20.020 1.00 97.50 O \\\\nATOM 524 N ILE A 67 -16.002 18.076 19.789 1.00 96.58 N \\\\nATOM 525 CA ILE A 67 -14.770 18.550 20.423 1.00 96.58 C \\\\nATOM 526 C ILE A 67 -14.099 19.604 19.526 1.00 96.58 C \\\\nATOM 527 CB ILE A 67 -13.795 17.398 20.776 1.00 96.58 C \\\\nATOM 528 O ILE A 67 -14.213 19.500 18.301 1.00 96.58 O \\\\nATOM 529 CG1 ILE A 67 -13.241 16.667 19.533 1.00 96.58 C \\\\nATOM 530 CG2 ILE A 67 -14.426 16.406 21.772 1.00 96.58 C \\\\nATOM 531 CD1 ILE A 67 -12.138 15.653 19.860 1.00 96.58 C \\\\nATOM 532 N PRO A 68 -13.321 20.546 20.093 1.00 95.38 N \\\\nATOM 533 CA PRO A 68 -12.526 21.483 19.303 1.00 95.38 C \\\\nATOM 534 C PRO A 68 -11.526 20.769 18.386 1.00 95.38 C \\\\nATOM 535 CB PRO A 68 -11.821 22.392 20.315 1.00 95.38 C \\\\nATOM 536 O PRO A 68 -10.821 19.845 18.818 1.00 95.38 O \\\\nATOM 537 CG PRO A 68 -12.757 22.354 21.521 1.00 95.38 C \\\\nATOM 538 CD PRO A 68 -13.292 20.923 21.498 1.00 95.38 C \\\\nATOM 539 N ARG A 69 -11.451 21.219 17.131 1.00 95.13 N \\\\nATOM 540 CA ARG A 69 -10.511 20.757 16.106 1.00 95.13 C \\\\nATOM 541 C ARG A 69 -9.103 21.296 16.394 1.00 95.13 C \\\\nATOM 542 CB ARG A 69 -11.061 21.203 14.735 1.00 95.13 C \\\\nATOM 543 O ARG A 69 -8.932 22.446 16.781 1.00 95.13 O \\\\nATOM 544 CG ARG A 69 -10.229 20.703 13.544 1.00 95.13 C \\\\nATOM 545 CD ARG A 69 -10.828 21.090 12.187 1.00 95.13 C \\\\nATOM 546 NE ARG A 69 -12.138 20.456 11.968 1.00 95.13 N \\\\nATOM 547 NH1 ARG A 69 -11.563 18.720 10.567 1.00 95.13 N \\\\nATOM 548 NH2 ARG A 69 -13.693 19.061 11.108 1.00 95.13 N \\\\nATOM 549 CZ ARG A 69 -12.449 19.415 11.226 1.00 95.13 C \\\\nATOM 550 N SER A 70 -8.076 20.463 16.218 1.00 93.69 N \\\\nATOM 551 CA SER A 70 -6.675 20.911 16.235 1.00 93.69 C \\\\nATOM 552 C SER A 70 -6.253 21.450 14.865 1.00 93.69 C \\\\nATOM 553 CB SER A 70 -5.742 19.766 16.648 1.00 93.69 C \\\\nATOM 554 O SER A 70 -6.850 21.094 13.851 1.00 93.69 O \\\\nATOM 555 OG SER A 70 -5.823 18.716 15.711 1.00 93.69 O \\\\nATOM 556 N LEU A 71 -5.163 22.222 14.818 1.00 90.27 N \\\\nATOM 557 CA LEU A 71 -4.580 22.745 13.570 1.00 90.27 C \\\\nATOM 558 C LEU A 71 -4.316 21.657 12.507 1.00 90.27 C \\\\nATOM 559 CB LEU A 71 -3.256 23.464 13.900 1.00 90.27 C \\\\nATOM 560 O LEU A 71 -4.434 21.918 11.318 1.00 90.27 O \\\\nATOM 561 CG LEU A 71 -3.372 24.686 14.832 1.00 90.27 C \\\\nATOM 562 CD1 LEU A 71 -1.974 25.203 15.173 1.00 90.27 C \\\\nATOM 563 CD2 LEU A 71 -4.171 25.824 14.201 1.00 90.27 C \\\\nATOM 564 N ASP A 72 -3.990 20.431 12.932 1.00 89.02 N \\\\nATOM 565 CA ASP A 72 -3.747 19.272 12.060 1.00 89.02 C \\\\nATOM 566 C ASP A 72 -4.926 18.276 11.996 1.00 89.02 C \\\\nATOM 567 CB ASP A 72 -2.433 18.589 12.485 1.00 89.02 C \\\\nATOM 568 O ASP A 72 -4.781 17.172 11.472 1.00 89.02 O \\\\nATOM 569 CG ASP A 72 -2.514 17.778 13.788 1.00 89.02 C \\\\nATOM 570 OD1 ASP A 72 -3.458 17.970 14.592 1.00 89.02 O \\\\nATOM 571 OD2 ASP A 72 -1.606 16.927 13.988 1.00 89.02 O \\\\nATOM 572 N GLY A 73 -6.075 18.615 12.589 1.00 90.68 N \\\\nATOM 573 CA GLY A 73 -7.268 17.767 12.680 1.00 90.68 C \\\\nATOM 574 C GLY A 73 -7.142 16.496 13.539 1.00 90.68 C \\\\nATOM 575 O GLY A 73 -8.121 15.751 13.646 1.00 90.68 O \\\\nATOM 576 N ARG A 74 -5.982 16.216 14.152 1.00 92.97 N \\\\nATOM 577 CA ARG A 74 -5.710 14.993 14.927 1.00 92.97 C \\\\nATOM 578 C ARG A 74 -5.775 15.211 16.439 1.00 92.97 C \\\\nATOM 579 CB ARG A 74 -4.347 14.404 14.541 1.00 92.97 C \\\\nATOM 580 O ARG A 74 -5.153 16.105 17.007 1.00 92.97 O \\\\nATOM 581 CG ARG A 74 -4.292 13.941 13.076 1.00 92.97 C \\\\nATOM 582 CD ARG A 74 -2.922 13.364 12.704 1.00 92.97 C \\\\nATOM 583 NE ARG A 74 -1.854 14.364 12.867 1.00 92.97 N \\\\nATOM 584 NH1 ARG A 74 -0.127 13.265 11.816 1.00 92.97 N \\\\nATOM 585 NH2 ARG A 74 0.142 15.350 12.593 1.00 92.97 N \\\\nATOM 586 CZ ARG A 74 -0.619 14.312 12.419 1.00 92.97 C \\\\nATOM 587 N LEU A 75 -6.436 14.284 17.124 1.00 94.38 N \\\\nATOM 588 CA LEU A 75 -6.420 14.175 18.577 1.00 94.38 C \\\\nATOM 589 C LEU A 75 -5.216 13.339 19.036 1.00 94.38 C \\\\nATOM 590 CB LEU A 75 -7.766 13.584 19.026 1.00 94.38 C \\\\nATOM 591 O LEU A 75 -4.989 12.231 18.547 1.00 94.38 O \\\\nATOM 592 CG LEU A 75 -7.917 13.386 20.543 1.00 94.38 C \\\\nATOM 593 CD1 LEU A 75 -7.888 14.711 21.312 1.00 94.38 C \\\\nATOM 594 CD2 LEU A 75 -9.250 12.703 20.838 1.00 94.38 C \\\\nATOM 595 N GLN A 76 -4.470 13.843 20.021 1.00 93.91 N \\\\nATOM 596 CA GLN A 76 -3.434 13.075 20.711 1.00 93.91 C \\\\nATOM 597 C GLN A 76 -4.001 12.383 21.959 1.00 93.91 C \\\\nATOM 598 CB GLN A 76 -2.228 13.973 21.025 1.00 93.91 C \\\\nATOM 599 O GLN A 76 -4.605 13.023 22.821 1.00 93.91 O \\\\nATOM 600 CG GLN A 76 -1.059 13.148 21.595 1.00 93.91 C \\\\nATOM 601 CD GLN A 76 0.254 13.919 21.672 1.00 93.91 C \\\\nATOM 602 NE2 GLN A 76 1.165 13.490 22.517 1.00 93.91 N \\\\nATOM 603 OE1 GLN A 76 0.496 14.875 20.951 1.00 93.91 O \\\\nATOM 604 N VAL A 77 -3.755 11.077 22.078 1.00 91.95 N \\\\nATOM 605 CA VAL A 77 -4.080 10.257 23.252 1.00 91.95 C \\\\nATOM 606 C VAL A 77 -2.822 9.505 23.690 1.00 91.95 C \\\\nATOM 607 CB VAL A 77 -5.244 9.286 22.969 1.00 91.95 C \\\\nATOM 608 O VAL A 77 -2.366 8.565 23.031 1.00 91.95 O \\\\nATOM 609 CG1 VAL A 77 -5.582 8.478 24.229 1.00 91.95 C \\\\nATOM 610 CG2 VAL A 77 -6.518 10.015 22.520 1.00 91.95 C \\\\nATOM 611 N SER A 78 -2.256 9.910 24.831 1.00 89.64 N \\\\nATOM 612 CA SER A 78 -0.940 9.453 25.304 1.00 89.64 C \\\\nATOM 613 C SER A 78 0.139 9.719 24.234 1.00 89.64 C \\\\nATOM 614 CB SER A 78 -1.034 7.999 25.813 1.00 89.64 C \\\\nATOM 615 O SER A 78 0.383 10.877 23.894 1.00 89.64 O \\\\nATOM 616 OG SER A 78 -0.107 7.700 26.853 1.00 89.64 O \\\\nATOM 617 N HIS A 79 0.750 8.669 23.679 1.00 87.62 N \\\\nATOM 618 CA HIS A 79 1.822 8.748 22.677 1.00 87.62 C \\\\nATOM 619 C HIS A 79 1.325 8.524 21.236 1.00 87.62 C \\\\nATOM 620 CB HIS A 79 2.944 7.764 23.061 1.00 87.62 C \\\\nATOM 621 O HIS A 79 2.130 8.502 20.315 1.00 87.62 O \\\\nATOM 622 CG HIS A 79 3.317 7.846 24.520 1.00 87.62 C \\\\nATOM 623 CD2 HIS A 79 2.824 7.047 25.515 1.00 87.62 C \\\\nATOM 624 ND1 HIS A 79 4.077 8.821 25.124 1.00 87.62 N \\\\nATOM 625 CE1 HIS A 79 4.026 8.622 26.453 1.00 87.62 C \\\\nATOM 626 NE2 HIS A 79 3.222 7.582 26.741 1.00 87.62 N \\\\nATOM 627 N ARG A 80 0.011 8.342 21.023 1.00 89.06 N \\\\nATOM 628 CA ARG A 80 -0.589 8.120 19.695 1.00 89.06 C \\\\nATOM 629 C ARG A 80 -1.371 9.360 19.252 1.00 89.06 C \\\\nATOM 630 CB ARG A 80 -1.469 6.850 19.695 1.00 89.06 C \\\\nATOM 631 O ARG A 80 -2.094 9.946 20.059 1.00 89.06 O \\\\nATOM 632 CG ARG A 80 -0.694 5.556 20.025 1.00 89.06 C \\\\nATOM 633 CD ARG A 80 -1.591 4.306 19.924 1.00 89.06 C \\\\nATOM 634 NE ARG A 80 -0.844 3.050 20.173 1.00 89.06 N \\\\nATOM 635 NH1 ARG A 80 -2.641 1.599 20.215 1.00 89.06 N \\\\nATOM 636 NH2 ARG A 80 -0.578 0.789 20.395 1.00 89.06 N \\\\nATOM 637 CZ ARG A 80 -1.357 1.827 20.262 1.00 89.06 C \\\\nATOM 638 N LYS A 81 -1.257 9.740 17.976 1.00 91.08 N \\\\nATOM 639 CA LYS A 81 -2.114 10.740 17.313 1.00 91.08 C \\\\nATOM 640 C LYS A 81 -3.033 10.033 16.320 1.00 91.08 C \\\\nATOM 641 CB LYS A 81 -1.278 11.818 16.596 1.00 91.08 C \\\\nATOM 642 O LYS A 81 -2.574 9.153 15.603 1.00 91.08 O \\\\nATOM 643 CG LYS A 81 -0.553 12.772 17.558 1.00 91.08 C \\\\nATOM 644 CD LYS A 81 0.071 13.948 16.788 1.00 91.08 C \\\\nATOM 645 CE LYS A 81 0.707 14.966 17.745 1.00 91.08 C \\\\nATOM 646 NZ LYS A 81 1.119 16.202 17.030 1.00 91.08 N \\\\nATOM 647 N GLY A 82 -4.296 10.436 16.252 1.00 92.21 N \\\\nATOM 648 CA GLY A 82 -5.266 9.886 15.305 1.00 92.21 C \\\\nATOM 649 C GLY A 82 -6.428 10.841 15.063 1.00 92.21 C \\\\nATOM 650 O GLY A 82 -6.586 11.836 15.770 1.00 92.21 O \\\\nATOM 651 N LEU A 83 -7.242 10.562 14.049 1.00 94.68 N \\\\nATOM 652 CA LEU A 83 -8.426 11.370 13.766 1.00 94.68 C \\\\nATOM 653 C LEU A 83 -9.513 11.089 14.819 1.00 94.68 C \\\\nATOM 654 CB LEU A 83 -8.899 11.097 12.332 1.00 94.68 C \\\\nATOM 655 O LEU A 83 -9.783 9.923 15.107 1.00 94.68 O \\\\nATOM 656 CG LEU A 83 -7.914 11.591 11.254 1.00 94.68 C \\\\nATOM 657 CD1 LEU A 83 -8.412 11.182 9.874 1.00 94.68 C \\\\nATOM 658 CD2 LEU A 83 -7.753 13.111 11.288 1.00 94.68 C \\\\nATOM 659 N PRO A 84 -10.135 12.117 15.424 1.00 96.13 N \\\\nATOM 660 CA PRO A 84 -10.963 11.926 16.613 1.00 96.13 C \\\\nATOM 661 C PRO A 84 -12.207 11.073 16.345 1.00 96.13 C \\\\nATOM 662 CB PRO A 84 -11.291 13.335 17.107 1.00 96.13 C \\\\nATOM 663 O PRO A 84 -12.475 10.141 17.096 1.00 96.13 O \\\\nATOM 664 CG PRO A 84 -11.097 14.233 15.887 1.00 96.13 C \\\\nATOM 665 CD PRO A 84 -9.985 13.531 15.117 1.00 96.13 C \\\\nATOM 666 N HIS A 85 -12.917 11.321 15.245 1.00 96.28 N \\\\nATOM 667 CA HIS A 85 -14.066 10.508 14.841 1.00 96.28 C \\\\nATOM 668 C HIS A 85 -13.681 9.035 14.599 1.00 96.28 C \\\\nATOM 669 CB HIS A 85 -14.733 11.152 13.620 1.00 96.28 C \\\\nATOM 670 O HIS A 85 -14.369 8.151 15.099 1.00 96.28 O \\\\nATOM 671 CG HIS A 85 -13.853 11.227 12.398 1.00 96.28 C \\\\nATOM 672 CD2 HIS A 85 -13.950 10.425 11.294 1.00 96.28 C \\\\nATOM 673 ND1 HIS A 85 -12.801 12.094 12.184 1.00 96.28 N \\\\nATOM 674 CE1 HIS A 85 -12.266 11.799 10.989 1.00 96.28 C \\\\nATOM 675 NE2 HIS A 85 -12.924 10.787 10.421 1.00 96.28 N \\\\nATOM 676 N VAL A 86 -12.538 8.761 13.950 1.00 95.91 N \\\\nATOM 677 CA VAL A 86 -12.007 7.394 13.763 1.00 95.91 C \\\\nATOM 678 C VAL A 86 -11.714 6.721 15.103 1.00 95.91 C \\\\nATOM 679 CB VAL A 86 -10.731 7.378 12.895 1.00 95.91 C \\\\nATOM 680 O VAL A 86 -12.126 5.586 15.305 1.00 95.91 O \\\\nATOM 681 CG1 VAL A 86 -10.186 5.964 12.647 1.00 95.91 C \\\\nATOM 682 CG2 VAL A 86 -10.992 7.999 11.526 1.00 95.91 C \\\\nATOM 683 N ILE A 87 -11.056 7.416 16.041 1.00 95.75 N \\\\nATOM 684 CA ILE A 87 -10.737 6.877 17.378 1.00 95.75 C \\\\nATOM 685 C ILE A 87 -12.005 6.382 18.085 1.00 95.75 C \\\\nATOM 686 CB ILE A 87 -9.989 7.938 18.229 1.00 95.75 C \\\\nATOM 687 O ILE A 87 -12.017 5.278 18.627 1.00 95.75 O \\\\nATOM 688 CG1 ILE A 87 -8.549 8.131 17.697 1.00 95.75 C \\\\nATOM 689 CG2 ILE A 87 -9.975 7.568 19.729 1.00 95.75 C \\\\nATOM 690 CD1 ILE A 87 -7.835 9.374 18.251 1.00 95.75 C \\\\nATOM 691 N TYR A 88 -13.070 7.184 18.078 1.00 97.01 N \\\\nATOM 692 CA TYR A 88 -14.292 6.876 18.820 1.00 97.01 C \\\\nATOM 693 C TYR A 88 -15.236 5.921 18.067 1.00 97.01 C \\\\nATOM 694 CB TYR A 88 -14.923 8.197 19.280 1.00 97.01 C \\\\nATOM 695 O TYR A 88 -15.862 5.073 18.706 1.00 97.01 O \\\\nATOM 696 CG TYR A 88 -14.039 8.958 20.269 1.00 97.01 C \\\\nATOM 697 CD1 TYR A 88 -13.650 8.363 21.488 1.00 97.01 C \\\\nATOM 698 CD2 TYR A 88 -13.542 10.235 19.946 1.00 97.01 C \\\\nATOM 699 CE1 TYR A 88 -12.758 9.025 22.356 1.00 97.01 C \\\\nATOM 700 CE2 TYR A 88 -12.657 10.909 20.809 1.00 97.01 C \\\\nATOM 701 OH TYR A 88 -11.359 10.917 22.833 1.00 97.01 O \\\\nATOM 702 CZ TYR A 88 -12.249 10.297 22.010 1.00 97.01 C \\\\nATOM 703 N CYS A 89 -15.259 5.944 16.728 1.00 97.14 N \\\\nATOM 704 CA CYS A 89 -15.911 4.899 15.927 1.00 97.14 C \\\\nATOM 705 C CYS A 89 -15.223 3.538 16.102 1.00 97.14 C \\\\nATOM 706 CB CYS A 89 -15.940 5.300 14.446 1.00 97.14 C \\\\nATOM 707 O CYS A 89 -15.909 2.531 16.282 1.00 97.14 O \\\\nATOM 708 SG CYS A 89 -17.012 6.741 14.207 1.00 97.14 S \\\\nATOM 709 N ARG A 90 -13.881 3.502 16.131 1.00 94.96 N \\\\nATOM 710 CA ARG A 90 -13.118 2.270 16.374 1.00 94.96 C \\\\nATOM 711 C ARG A 90 -13.416 1.683 17.753 1.00 94.96 C \\\\nATOM 712 CB ARG A 90 -11.610 2.504 16.148 1.00 94.96 C \\\\nATOM 713 O ARG A 90 -13.631 0.485 17.889 1.00 94.96 O \\\\nATOM 714 CG ARG A 90 -10.822 1.179 16.147 1.00 94.96 C \\\\nATOM 715 CD ARG A 90 -9.299 1.349 16.072 1.00 94.96 C \\\\nATOM 716 NE ARG A 90 -8.859 1.913 14.783 1.00 94.96 N \\\\nATOM 717 NH1 ARG A 90 -6.593 1.849 15.128 1.00 94.96 N \\\\nATOM 718 NH2 ARG A 90 -7.394 2.582 13.182 1.00 94.96 N \\\\nATOM 719 CZ ARG A 90 -7.620 2.119 14.376 1.00 94.96 C \\\\nATOM 720 N LEU A 91 -13.475 2.541 18.774 1.00 95.35 N \\\\nATOM 721 CA LEU A 91 -13.684 2.125 20.161 1.00 95.35 C \\\\nATOM 722 C LEU A 91 -15.085 1.529 20.399 1.00 95.35 C \\\\nATOM 723 CB LEU A 91 -13.349 3.325 21.071 1.00 95.35 C \\\\nATOM 724 O LEU A 91 -15.193 0.505 21.071 1.00 95.35 O \\\\nATOM 725 CG LEU A 91 -13.069 2.959 22.541 1.00 95.35 C \\\\nATOM 726 CD1 LEU A 91 -12.143 4.000 23.179 1.00 95.35 C \\\\nATOM 727 CD2 LEU A 91 -14.329 2.914 23.405 1.00 95.35 C \\\\nATOM 728 N TRP A 92 -16.144 2.141 19.854 1.00 96.60 N \\\\nATOM 729 CA TRP A 92 -17.537 1.766 20.157 1.00 96.60 C \\\\nATOM 730 C TRP A 92 -18.284 0.994 19.062 1.00 96.60 C \\\\nATOM 731 CB TRP A 92 -18.313 3.021 20.582 1.00 96.60 C \\\\nATOM 732 O TRP A 92 -19.358 0.464 19.347 1.00 96.60 O \\\\nATOM 733 CG TRP A 92 -17.957 3.535 21.942 1.00 96.60 C \\\\nATOM 734 CD1 TRP A 92 -18.066 2.819 23.082 1.00 96.60 C \\\\nATOM 735 CD2 TRP A 92 -17.462 4.850 22.345 1.00 96.60 C \\\\nATOM 736 CE2 TRP A 92 -17.256 4.832 23.759 1.00 96.60 C \\\\nATOM 737 CE3 TRP A 92 -17.178 6.059 21.672 1.00 96.60 C \\\\nATOM 738 NE1 TRP A 92 -17.647 3.572 24.156 1.00 96.60 N \\\\nATOM 739 CH2 TRP A 92 -16.458 7.112 23.753 1.00 96.60 C \\\\nATOM 740 CZ2 TRP A 92 -16.732 5.930 24.453 1.00 96.60 C \\\\nATOM 741 CZ3 TRP A 92 -16.710 7.188 22.373 1.00 96.60 C \\\\nATOM 742 N ARG A 93 -17.759 0.902 17.831 1.00 95.15 N \\\\nATOM 743 CA ARG A 93 -18.455 0.233 16.712 1.00 95.15 C \\\\nATOM 744 C ARG A 93 -17.601 -0.788 15.968 1.00 95.15 C \\\\nATOM 745 CB ARG A 93 -19.070 1.267 15.755 1.00 95.15 C \\\\nATOM 746 O ARG A 93 -17.990 -1.951 15.932 1.00 95.15 O \\\\nATOM 747 CG ARG A 93 -20.137 2.119 16.462 1.00 95.15 C \\\\nATOM 748 CD ARG A 93 -20.863 3.041 15.485 1.00 95.15 C \\\\nATOM 749 NE ARG A 93 -21.743 2.298 14.563 1.00 95.15 N \\\\nATOM 750 NH1 ARG A 93 -22.348 4.110 13.332 1.00 95.15 N \\\\nATOM 751 NH2 ARG A 93 -23.186 2.127 12.794 1.00 95.15 N \\\\nATOM 752 CZ ARG A 93 -22.420 2.840 13.570 1.00 95.15 C \\\\nATOM 753 N TRP A 94 -16.461 -0.377 15.415 1.00 94.17 N \\\\nATOM 754 CA TRP A 94 -15.676 -1.193 14.474 1.00 94.17 C \\\\nATOM 755 C TRP A 94 -14.194 -1.247 14.882 1.00 94.17 C \\\\nATOM 756 CB TRP A 94 -15.855 -0.623 13.061 1.00 94.17 C \\\\nATOM 757 O TRP A 94 -13.423 -0.380 14.469 1.00 94.17 O \\\\nATOM 758 CG TRP A 94 -17.264 -0.527 12.567 1.00 94.17 C \\\\nATOM 759 CD1 TRP A 94 -18.073 -1.569 12.277 1.00 94.17 C \\\\nATOM 760 CD2 TRP A 94 -18.039 0.675 12.283 1.00 94.17 C \\\\nATOM 761 CE2 TRP A 94 -19.324 0.281 11.803 1.00 94.17 C \\\\nATOM 762 CE3 TRP A 94 -17.778 2.060 12.376 1.00 94.17 C \\\\nATOM 763 NE1 TRP A 94 -19.289 -1.098 11.818 1.00 94.17 N \\\\nATOM 764 CH2 TRP A 94 -19.992 2.588 11.501 1.00 94.17 C \\\\nATOM 765 CZ2 TRP A 94 -20.291 1.216 11.407 1.00 94.17 C \\\\nATOM 766 CZ3 TRP A 94 -18.748 3.008 11.999 1.00 94.17 C \\\\nATOM 767 N PRO A 95 -13.767 -2.218 15.713 1.00 91.85 N \\\\nATOM 768 CA PRO A 95 -12.377 -2.334 16.180 1.00 91.85 C \\\\nATOM 769 C PRO A 95 -11.349 -2.409 15.044 1.00 91.85 C \\\\nATOM 770 CB PRO A 95 -12.335 -3.624 17.007 1.00 91.85 C \\\\nATOM 771 O PRO A 95 -10.232 -1.917 15.177 1.00 91.85 O \\\\nATOM 772 CG PRO A 95 -13.776 -3.784 17.471 1.00 91.85 C \\\\nATOM 773 CD PRO A 95 -14.589 -3.261 16.296 1.00 91.85 C \\\\nATOM 774 N ASP A 96 -11.778 -2.981 13.924 1.00 88.11 N \\\\nATOM 775 CA ASP A 96 -11.075 -3.212 12.665 1.00 88.11 C \\\\nATOM 776 C ASP A 96 -11.137 -2.021 11.684 1.00 88.11 C \\\\nATOM 777 CB ASP A 96 -11.697 -4.475 12.048 1.00 88.11 C \\\\nATOM 778 O ASP A 96 -10.795 -2.157 10.514 1.00 88.11 O \\\\nATOM 779 CG ASP A 96 -13.152 -4.244 11.620 1.00 88.11 C \\\\nATOM 780 OD1 ASP A 96 -13.968 -3.756 12.443 1.00 88.11 O \\\\nATOM 781 OD2 ASP A 96 -13.460 -4.509 10.440 1.00 88.11 O \\\\nATOM 782 N LEU A 97 -11.589 -0.845 12.128 1.00 90.03 N \\\\nATOM 783 CA LEU A 97 -11.603 0.378 11.321 1.00 90.03 C \\\\nATOM 784 C LEU A 97 -10.190 0.968 11.204 1.00 90.03 C \\\\nATOM 785 CB LEU A 97 -12.558 1.369 12.005 1.00 90.03 C \\\\nATOM 786 O LEU A 97 -9.690 1.539 12.177 1.00 90.03 O \\\\nATOM 787 CG LEU A 97 -12.699 2.703 11.262 1.00 90.03 C \\\\nATOM 788 CD1 LEU A 97 -13.601 2.541 10.045 1.00 90.03 C \\\\nATOM 789 CD2 LEU A 97 -13.313 3.751 12.188 1.00 90.03 C \\\\nATOM 790 N HIS A 98 -9.561 0.935 10.034 1.00 83.53 N \\\\nATOM 791 CA HIS A 98 -8.185 1.398 9.822 1.00 83.53 C \\\\nATOM 792 C HIS A 98 -8.109 2.885 9.443 1.00 83.53 C \\\\nATOM 793 CB HIS A 98 -7.491 0.500 8.787 1.00 83.53 C \\\\nATOM 794 O HIS A 98 -7.307 3.624 10.024 1.00 83.53 O \\\\nATOM 795 CG HIS A 98 -7.350 -0.918 9.279 1.00 83.53 C \\\\nATOM 796 CD2 HIS A 98 -6.292 -1.441 9.975 1.00 83.53 C \\\\nATOM 797 ND1 HIS A 98 -8.318 -1.894 9.231 1.00 83.53 N \\\\nATOM 798 CE1 HIS A 98 -7.867 -2.964 9.902 1.00 83.53 C \\\\nATOM 799 NE2 HIS A 98 -6.648 -2.722 10.403 1.00 83.53 N \\\\nATOM 800 N SER A 99 -8.966 3.349 8.528 1.00 85.84 N \\\\nATOM 801 CA SER A 99 -8.930 4.700 7.946 1.00 85.84 C \\\\nATOM 802 C SER A 99 -10.231 5.484 8.140 1.00 85.84 C \\\\nATOM 803 CB SER A 99 -8.601 4.601 6.452 1.00 85.84 C \\\\nATOM 804 O SER A 99 -11.318 4.925 8.226 1.00 85.84 O \\\\nATOM 805 OG SER A 99 -8.411 5.893 5.882 1.00 85.84 O \\\\nATOM 806 N HIS A 100 -10.141 6.818 8.123 1.00 89.28 N \\\\nATOM 807 CA HIS A 100 -11.322 7.683 7.992 1.00 89.28 C \\\\nATOM 808 C HIS A 100 -12.066 7.522 6.664 1.00 89.28 C \\\\nATOM 809 CB HIS A 100 -10.934 9.152 8.163 1.00 89.28 C \\\\nATOM 810 O HIS A 100 -13.252 7.814 6.608 1.00 89.28 O \\\\nATOM 811 CG HIS A 100 -10.106 9.767 7.057 1.00 89.28 C \\\\nATOM 812 CD2 HIS A 100 -10.271 11.039 6.582 1.00 89.28 C \\\\nATOM 813 ND1 HIS A 100 -9.054 9.208 6.355 1.00 89.28 N \\\\nATOM 814 CE1 HIS A 100 -8.602 10.136 5.494 1.00 89.28 C \\\\nATOM 815 NE2 HIS A 100 -9.290 11.280 5.620 1.00 89.28 N \\\\nATOM 816 N HIS A 101 -11.389 7.043 5.617 1.00 87.61 N \\\\nATOM 817 CA HIS A 101 -11.995 6.815 4.305 1.00 87.61 C \\\\nATOM 818 C HIS A 101 -13.023 5.667 4.339 1.00 87.61 C \\\\nATOM 819 CB HIS A 101 -10.877 6.550 3.288 1.00 87.61 C \\\\nATOM 820 O HIS A 101 -13.914 5.620 3.502 1.00 87.61 O \\\\nATOM 821 CG HIS A 101 -9.903 7.679 3.043 1.00 87.61 C \\\\nATOM 822 CD2 HIS A 101 -8.576 7.525 2.753 1.00 87.61 C \\\\nATOM 823 ND1 HIS A 101 -10.253 9.008 2.824 1.00 87.61 N \\\\nATOM 824 CE1 HIS A 101 -9.148 9.614 2.366 1.00 87.61 C \\\\nATOM 825 NE2 HIS A 101 -8.114 8.755 2.330 1.00 87.61 N \\\\nATOM 826 N GLU A 102 -12.947 4.778 5.340 1.00 91.34 N \\\\nATOM 827 CA GLU A 102 -13.962 3.748 5.612 1.00 91.34 C \\\\nATOM 828 C GLU A 102 -15.215 4.320 6.298 1.00 91.34 C \\\\nATOM 829 CB GLU A 102 -13.376 2.657 6.521 1.00 91.34 C \\\\nATOM 830 O GLU A 102 -16.148 3.567 6.567 1.00 91.34 O \\\\nATOM 831 CG GLU A 102 -12.282 1.772 5.924 1.00 91.34 C \\\\nATOM 832 CD GLU A 102 -11.709 0.897 7.044 1.00 91.34 C \\\\nATOM 833 OE1 GLU A 102 -10.610 1.257 7.528 1.00 91.34 O \\\\nATOM 834 OE2 GLU A 102 -12.403 -0.044 7.507 1.00 91.34 O \\\\nATOM 835 N LEU A 103 -15.260 5.621 6.617 1.00 94.44 N \\\\nATOM 836 CA LEU A 103 -16.401 6.278 7.252 1.00 94.44 C \\\\nATOM 837 C LEU A 103 -17.027 7.334 6.336 1.00 94.44 C \\\\nATOM 838 CB LEU A 103 -15.993 6.932 8.583 1.00 94.44 C \\\\nATOM 839 O LEU A 103 -16.368 8.273 5.892 1.00 94.44 O \\\\nATOM 840 CG LEU A 103 -15.497 5.984 9.685 1.00 94.44 C \\\\nATOM 841 CD1 LEU A 103 -15.192 6.821 10.931 1.00 94.44 C \\\\nATOM 842 CD2 LEU A 103 -16.527 4.918 10.060 1.00 94.44 C \\\\nATOM 843 N ARG A 104 -18.346 7.257 6.169 1.00 93.98 N \\\\nATOM 844 CA ARG A 104 -19.178 8.341 5.637 1.00 93.98 C \\\\nATOM 845 C ARG A 104 -19.914 9.007 6.796 1.00 93.98 C \\\\nATOM 846 CB ARG A 104 -20.119 7.758 4.574 1.00 93.98 C \\\\nATOM 847 O ARG A 104 -20.406 8.315 7.679 1.00 93.98 O \\\\nATOM 848 CG ARG A 104 -20.871 8.846 3.792 1.00 93.98 C \\\\nATOM 849 CD ARG A 104 -21.746 8.249 2.682 1.00 93.98 C \\\\nATOM 850 NE ARG A 104 -20.942 7.590 1.630 1.00 93.98 N \\\\nATOM 851 NH1 ARG A 104 -22.690 6.672 0.453 1.00 93.98 N \\\\nATOM 852 NH2 ARG A 104 -20.597 6.298 -0.217 1.00 93.98 N \\\\nATOM 853 CZ ARG A 104 -21.412 6.861 0.631 1.00 93.98 C \\\\nATOM 854 N ALA A 105 -19.987 10.334 6.832 1.00 95.58 N \\\\nATOM 855 CA ALA A 105 -20.825 11.016 7.817 1.00 95.58 C \\\\nATOM 856 C ALA A 105 -22.312 10.886 7.449 1.00 95.58 C \\\\nATOM 857 CB ALA A 105 -20.386 12.473 7.934 1.00 95.58 C \\\\nATOM 858 O ALA A 105 -22.654 10.912 6.269 1.00 95.58 O \\\\nATOM 859 N MET A 106 -23.180 10.771 8.454 1.00 94.73 N \\\\nATOM 860 CA MET A 106 -24.633 10.840 8.263 1.00 94.73 C \\\\nATOM 861 C MET A 106 -25.040 12.262 7.857 1.00 94.73 C \\\\nATOM 862 CB MET A 106 -25.367 10.441 9.556 1.00 94.73 C \\\\nATOM 863 O MET A 106 -24.473 13.227 8.368 1.00 94.73 O \\\\nATOM 864 CG MET A 106 -25.076 9.008 10.024 1.00 94.73 C \\\\nATOM 865 SD MET A 106 -25.501 7.677 8.871 1.00 94.73 S \\\\nATOM 866 CE MET A 106 -27.310 7.807 8.826 1.00 94.73 C \\\\nATOM 867 N GLU A 107 -26.060 12.403 7.010 1.00 93.15 N \\\\nATOM 868 CA GLU A 107 -26.558 13.710 6.533 1.00 93.15 C \\\\nATOM 869 C GLU A 107 -27.026 14.628 7.677 1.00 93.15 C \\\\nATOM 870 CB GLU A 107 -27.710 13.476 5.544 1.00 93.15 C \\\\nATOM 871 O GLU A 107 -26.850 15.841 7.622 1.00 93.15 O \\\\nATOM 872 CG GLU A 107 -27.247 12.693 4.303 1.00 93.15 C \\\\nATOM 873 CD GLU A 107 -28.367 12.438 3.284 1.00 93.15 C \\\\nATOM 874 OE1 GLU A 107 -28.010 11.970 2.181 1.00 93.15 O \\\\nATOM 875 OE2 GLU A 107 -29.546 12.670 3.630 1.00 93.15 O \\\\nATOM 876 N LEU A 108 -27.527 14.035 8.765 1.00 93.69 N \\\\nATOM 877 CA LEU A 108 -27.938 14.715 10.001 1.00 93.69 C \\\\nATOM 878 C LEU A 108 -26.760 15.276 10.835 1.00 93.69 C \\\\nATOM 879 CB LEU A 108 -28.760 13.713 10.841 1.00 93.69 C \\\\nATOM 880 O LEU A 108 -26.981 15.903 11.870 1.00 93.69 O \\\\nATOM 881 CG LEU A 108 -30.059 13.205 10.182 1.00 93.69 C \\\\nATOM 882 CD1 LEU A 108 -30.610 12.023 10.982 1.00 93.69 C \\\\nATOM 883 CD2 LEU A 108 -31.133 14.292 10.122 1.00 93.69 C \\\\nATOM 884 N CYS A 109 -25.503 15.021 10.455 1.00 96.21 N \\\\nATOM 885 CA CYS A 109 -24.330 15.402 11.242 1.00 96.21 C \\\\nATOM 886 C CYS A 109 -23.824 16.809 10.888 1.00 96.21 C \\\\nATOM 887 CB CYS A 109 -23.247 14.332 11.086 1.00 96.21 C \\\\nATOM 888 O CYS A 109 -22.939 16.987 10.050 1.00 96.21 O \\\\nATOM 889 SG CYS A 109 -21.880 14.671 12.240 1.00 96.21 S \\\\nATOM 890 N GLU A 110 -24.309 17.816 11.614 1.00 96.46 N \\\\nATOM 891 CA GLU A 110 -23.943 19.229 11.425 1.00 96.46 C \\\\nATOM 892 C GLU A 110 -22.450 19.545 11.646 1.00 96.46 C \\\\nATOM 893 CB GLU A 110 -24.740 20.085 12.415 1.00 96.46 C \\\\nATOM 894 O GLU A 110 -21.980 20.613 11.249 1.00 96.46 O \\\\nATOM 895 CG GLU A 110 -26.263 19.981 12.271 1.00 96.46 C \\\\nATOM 896 CD GLU A 110 -26.979 20.882 13.289 1.00 96.46 C \\\\nATOM 897 OE1 GLU A 110 -28.101 21.328 12.975 1.00 96.46 O \\\\nATOM 898 OE2 GLU A 110 -26.391 21.128 14.371 1.00 96.46 O \\\\nATOM 899 N PHE A 111 -21.695 18.655 12.297 1.00 97.34 N \\\\nATOM 900 CA PHE A 111 -20.281 18.845 12.653 1.00 97.34 C \\\\nATOM 901 C PHE A 111 -19.386 17.721 12.109 1.00 97.34 C \\\\nATOM 902 CB PHE A 111 -20.146 19.067 14.169 1.00 97.34 C \\\\nATOM 903 O PHE A 111 -18.363 17.375 12.709 1.00 97.34 O \\\\nATOM 904 CG PHE A 111 -20.828 20.321 14.674 1.00 97.34 C \\\\nATOM 905 CD1 PHE A 111 -20.106 21.524 14.784 1.00 97.34 C \\\\nATOM 906 CD2 PHE A 111 -22.187 20.286 15.038 1.00 97.34 C \\\\nATOM 907 CE1 PHE A 111 -20.739 22.681 15.274 1.00 97.34 C \\\\nATOM 908 CE2 PHE A 111 -22.828 21.447 15.497 1.00 97.34 C \\\\nATOM 909 CZ PHE A 111 -22.101 22.642 15.627 1.00 97.34 C \\\\nATOM 910 N ALA A 112 -19.768 17.115 10.985 1.00 95.98 N \\\\nATOM 911 CA ALA A 112 -19.009 16.040 10.359 1.00 95.98 C \\\\nATOM 912 C ALA A 112 -17.552 16.444 10.052 1.00 95.98 C \\\\nATOM 913 CB ALA A 112 -19.760 15.597 9.106 1.00 95.98 C \\\\nATOM 914 O ALA A 112 -17.249 17.588 9.699 1.00 95.98 O \\\\nATOM 915 N PHE A 113 -16.612 15.499 10.184 1.00 93.94 N \\\\nATOM 916 CA PHE A 113 -15.178 15.800 10.078 1.00 93.94 C \\\\nATOM 917 C PHE A 113 -14.775 16.480 8.756 1.00 93.94 C \\\\nATOM 918 CB PHE A 113 -14.367 14.516 10.278 1.00 93.94 C \\\\nATOM 919 O PHE A 113 -13.932 17.385 8.777 1.00 93.94 O \\\\nATOM 920 CG PHE A 113 -12.874 14.717 10.076 1.00 93.94 C \\\\nATOM 921 CD1 PHE A 113 -12.257 14.293 8.882 1.00 93.94 C \\\\nATOM 922 CD2 PHE A 113 -12.103 15.355 11.066 1.00 93.94 C \\\\nATOM 923 CE1 PHE A 113 -10.881 14.503 8.686 1.00 93.94 C \\\\nATOM 924 CE2 PHE A 113 -10.724 15.550 10.880 1.00 93.94 C \\\\nATOM 925 CZ PHE A 113 -10.117 15.137 9.681 1.00 93.94 C \\\\nATOM 926 N ASN A 114 -15.397 16.080 7.643 1.00 91.30 N \\\\nATOM 927 CA ASN A 114 -15.186 16.613 6.295 1.00 91.30 C \\\\nATOM 928 C ASN A 114 -15.691 18.056 6.101 1.00 91.30 C \\\\nATOM 929 CB ASN A 114 -15.829 15.658 5.264 1.00 91.30 C \\\\nATOM 930 O ASN A 114 -15.181 18.738 5.219 1.00 91.30 O \\\\nATOM 931 CG ASN A 114 -17.340 15.517 5.407 1.00 91.30 C \\\\nATOM 932 ND2 ASN A 114 -18.054 15.240 4.344 1.00 91.30 N \\\\nATOM 933 OD1 ASN A 114 -17.887 15.635 6.490 1.00 91.30 O \\\\nATOM 934 N MET A 115 -16.607 18.556 6.941 1.00 93.28 N \\\\nATOM 935 CA MET A 115 -17.109 19.941 6.870 1.00 93.28 C \\\\nATOM 936 C MET A 115 -16.089 20.993 7.338 1.00 93.28 C \\\\nATOM 937 CB MET A 115 -18.397 20.097 7.694 1.00 93.28 C \\\\nATOM 938 O MET A 115 -16.359 22.185 7.245 1.00 93.28 O \\\\nATOM 939 CG MET A 115 -19.531 19.178 7.245 1.00 93.28 C \\\\nATOM 940 SD MET A 115 -21.011 19.386 8.269 1.00 93.28 S \\\\nATOM 941 CE MET A 115 -22.025 20.428 7.188 1.00 93.28 C \\\\nATOM 942 N LYS A 116 -14.933 20.574 7.879 1.00 91.49 N \\\\nATOM 943 CA LYS A 116 -13.805 21.437 8.299 1.00 91.49 C \\\\nATOM 944 C LYS A 116 -14.143 22.582 9.284 1.00 91.49 C \\\\nATOM 945 CB LYS A 116 -13.025 21.940 7.064 1.00 91.49 C \\\\nATOM 946 O LYS A 116 -13.315 23.465 9.464 1.00 91.49 O \\\\nATOM 947 CG LYS A 116 -12.402 20.814 6.222 1.00 91.49 C \\\\nATOM 948 CD LYS A 116 -11.661 21.398 5.012 1.00 91.49 C \\\\nATOM 949 CE LYS A 116 -11.126 20.283 4.104 1.00 91.49 C \\\\nATOM 950 NZ LYS A 116 -10.485 20.836 2.882 1.00 91.49 N \\\\nATOM 951 N LYS A 117 -15.291 22.530 9.975 1.00 94.76 N \\\\nATOM 952 CA LYS A 117 -15.671 23.462 11.058 1.00 94.76 C \\\\nATOM 953 C LYS A 117 -14.675 23.438 12.231 1.00 94.76 C \\\\nATOM 954 CB LYS A 117 -17.094 23.133 11.562 1.00 94.76 C \\\\nATOM 955 O LYS A 117 -13.972 22.443 12.419 1.00 94.76 O \\\\nATOM 956 CG LYS A 117 -18.187 23.326 10.495 1.00 94.76 C \\\\nATOM 957 CD LYS A 117 -19.589 23.130 11.097 1.00 94.76 C \\\\nATOM 958 CE LYS A 117 -20.685 23.404 10.057 1.00 94.76 C \\\\nATOM 959 NZ LYS A 117 -22.042 23.260 10.645 1.00 94.76 N \\\\nATOM 960 N ASP A 118 -14.688 24.484 13.060 1.00 95.42 N \\\\nATOM 961 CA ASP A 118 -13.849 24.625 14.270 1.00 95.42 C \\\\nATOM 962 C ASP A 118 -14.050 23.504 15.300 1.00 95.42 C \\\\nATOM 963 CB ASP A 118 -14.163 25.963 14.953 1.00 95.42 C \\\\nATOM 964 O ASP A 118 -13.168 23.209 16.108 1.00 95.42 O \\\\nATOM 965 CG ASP A 118 -13.874 27.158 14.050 1.00 95.42 C \\\\nATOM 966 OD1 ASP A 118 -12.850 27.096 13.335 1.00 95.42 O \\\\nATOM 967 OD2 ASP A 118 -14.713 28.080 14.050 1.00 95.42 O \\\\nATOM 968 N GLU A 119 -15.197 22.831 15.240 1.00 96.27 N \\\\nATOM 969 CA GLU A 119 -15.482 21.617 15.990 1.00 96.27 C \\\\nATOM 970 C GLU A 119 -15.620 20.390 15.078 1.00 96.27 C \\\\nATOM 971 CB GLU A 119 -16.725 21.802 16.862 1.00 96.27 C \\\\nATOM 972 O GLU A 119 -15.860 20.478 13.870 1.00 96.27 O \\\\nATOM 973 CG GLU A 119 -16.575 22.893 17.932 1.00 96.27 C \\\\nATOM 974 CD GLU A 119 -17.483 22.585 19.128 1.00 96.27 C \\\\nATOM 975 OE1 GLU A 119 -16.925 22.384 20.230 1.00 96.27 O \\\\nATOM 976 OE2 GLU A 119 -18.703 22.390 18.922 1.00 96.27 O \\\\nATOM 977 N VAL A 120 -15.467 19.208 15.673 1.00 96.95 N \\\\nATOM 978 CA VAL A 120 -15.663 17.914 15.015 1.00 96.95 C \\\\nATOM 979 C VAL A 120 -16.561 17.015 15.856 1.00 96.95 C \\\\nATOM 980 CB VAL A 120 -14.313 17.253 14.669 1.00 96.95 C \\\\nATOM 981 O VAL A 120 -16.314 16.811 17.046 1.00 96.95 O \\\\nATOM 982 CG1 VAL A 120 -13.321 17.164 15.838 1.00 96.95 C \\\\nATOM 983 CG2 VAL A 120 -14.496 15.836 14.107 1.00 96.95 C \\\\nATOM 984 N CYS A 121 -17.576 16.433 15.216 1.00 97.92 N \\\\nATOM 985 CA CYS A 121 -18.431 15.420 15.813 1.00 97.92 C \\\\nATOM 986 C CYS A 121 -17.659 14.112 16.029 1.00 97.92 C \\\\nATOM 987 CB CYS A 121 -19.679 15.186 14.954 1.00 97.92 C \\\\nATOM 988 O CYS A 121 -17.033 13.574 15.111 1.00 97.92 O \\\\nATOM 989 SG CYS A 121 -20.832 14.159 15.908 1.00 97.92 S \\\\nATOM 990 N VAL A 122 -17.752 13.582 17.243 1.00 97.72 N \\\\nATOM 991 CA VAL A 122 -17.203 12.298 17.686 1.00 97.72 C \\\\nATOM 992 C VAL A 122 -18.285 11.307 18.125 1.00 97.72 C \\\\nATOM 993 CB VAL A 122 -16.141 12.495 18.782 1.00 97.72 C \\\\nATOM 994 O VAL A 122 -17.956 10.257 18.673 1.00 97.72 O \\\\nATOM 995 CG1 VAL A 122 -14.932 13.260 18.234 1.00 97.72 C \\\\nATOM 996 CG2 VAL A 122 -16.642 13.217 20.035 1.00 97.72 C \\\\nATOM 997 N ASN A 123 -19.565 11.613 17.879 1.00 97.71 N \\\\nATOM 998 CA ASN A 123 -20.654 10.650 18.046 1.00 97.71 C \\\\nATOM 999 C ASN A 123 -20.443 9.497 17.044 1.00 97.71 C \\\\nATOM 1000 CB ASN A 123 -22.010 11.357 17.833 1.00 97.71 C \\\\nATOM 1001 O ASN A 123 -20.509 9.739 15.837 1.00 97.71 O \\\\nATOM 1002 CG ASN A 123 -23.206 10.461 18.123 1.00 97.71 C \\\\nATOM 1003 ND2 ASN A 123 -24.356 11.036 18.386 1.00 97.71 N \\\\nATOM 1004 OD1 ASN A 123 -23.101 9.241 18.132 1.00 97.71 O \\\\nATOM 1005 N PRO A 124 -20.192 8.251 17.485 1.00 97.24 N \\\\nATOM 1006 CA PRO A 124 -19.894 7.164 16.560 1.00 97.24 C \\\\nATOM 1007 C PRO A 124 -21.113 6.735 15.729 1.00 97.24 C \\\\nATOM 1008 CB PRO A 124 -19.341 6.042 17.439 1.00 97.24 C \\\\nATOM 1009 O PRO A 124 -20.937 6.063 14.717 1.00 97.24 O \\\\nATOM 1010 CG PRO A 124 -20.066 6.254 18.763 1.00 97.24 C \\\\nATOM 1011 CD PRO A 124 -20.149 7.776 18.862 1.00 97.24 C \\\\nATOM 1012 N TYR A 125 -22.334 7.132 16.107 1.00 97.21 N \\\\nATOM 1013 CA TYR A 125 -23.568 6.894 15.342 1.00 97.21 C \\\\nATOM 1014 C TYR A 125 -23.873 8.001 14.322 1.00 97.21 C \\\\nATOM 1015 CB TYR A 125 -24.731 6.614 16.304 1.00 97.21 C \\\\nATOM 1016 O TYR A 125 -24.833 7.895 13.569 1.00 97.21 O \\\\nATOM 1017 CG TYR A 125 -24.449 5.401 17.166 1.00 97.21 C \\\\nATOM 1018 CD1 TYR A 125 -24.625 4.107 16.637 1.00 97.21 C \\\\nATOM 1019 CD2 TYR A 125 -23.912 5.567 18.455 1.00 97.21 C \\\\nATOM 1020 CE1 TYR A 125 -24.241 2.979 17.387 1.00 97.21 C \\\\nATOM 1021 CE2 TYR A 125 -23.528 4.440 19.204 1.00 97.21 C \\\\nATOM 1022 OH TYR A 125 -23.321 2.060 19.402 1.00 97.21 O \\\\nATOM 1023 CZ TYR A 125 -23.690 3.144 18.673 1.00 97.21 C \\\\nATOM 1024 N HIS A 126 -23.027 9.035 14.238 1.00 97.82 N \\\\nATOM 1025 CA HIS A 126 -23.063 10.054 13.176 1.00 97.82 C \\\\nATOM 1026 C HIS A 126 -22.159 9.726 11.984 1.00 97.82 C \\\\nATOM 1027 CB HIS A 126 -22.751 11.426 13.780 1.00 97.82 C \\\\nATOM 1028 O HIS A 126 -21.988 10.547 11.084 1.00 97.82 O \\\\nATOM 1029 CG HIS A 126 -23.879 12.016 14.583 1.00 97.82 C \\\\nATOM 1030 CD2 HIS A 126 -25.075 11.415 14.857 1.00 97.82 C \\\\nATOM 1031 ND1 HIS A 126 -23.925 13.346 15.007 1.00 97.82 N \\\\nATOM 1032 CE1 HIS A 126 -25.172 13.518 15.476 1.00 97.82 C \\\\nATOM 1033 NE2 HIS A 126 -25.864 12.375 15.425 1.00 97.82 N \\\\nATOM 1034 N TYR A 127 -21.611 8.513 11.960 1.00 97.31 N \\\\nATOM 1035 CA TYR A 127 -20.844 7.963 10.852 1.00 97.31 C \\\\nATOM 1036 C TYR A 127 -21.405 6.582 10.486 1.00 97.31 C \\\\nATOM 1037 CB TYR A 127 -19.353 7.915 11.234 1.00 97.31 C \\\\nATOM 1038 O TYR A 127 -21.826 5.831 11.364 1.00 97.31 O \\\\nATOM 1039 CG TYR A 127 -18.749 9.275 11.566 1.00 97.31 C \\\\nATOM 1040 CD1 TYR A 127 -18.178 10.061 10.546 1.00 97.31 C \\\\nATOM 1041 CD2 TYR A 127 -18.801 9.777 12.883 1.00 97.31 C \\\\nATOM 1042 CE1 TYR A 127 -17.676 11.346 10.836 1.00 97.31 C \\\\nATOM 1043 CE2 TYR A 127 -18.315 11.068 13.176 1.00 97.31 C \\\\nATOM 1044 OH TYR A 127 -17.256 13.099 12.420 1.00 97.31 O \\\\nATOM 1045 CZ TYR A 127 -17.754 11.859 12.148 1.00 97.31 C \\\\nATOM 1046 N GLN A 128 -21.398 6.218 9.210 1.00 94.94 N \\\\nATOM 1047 CA GLN A 128 -21.660 4.866 8.717 1.00 94.94 C \\\\nATOM 1048 C GLN A 128 -20.363 4.307 8.128 1.00 94.94 C \\\\nATOM 1049 CB GLN A 128 -22.818 4.891 7.707 1.00 94.94 C \\\\nATOM 1050 O GLN A 128 -19.571 5.061 7.559 1.00 94.94 O \\\\nATOM 1051 CG GLN A 128 -23.315 3.479 7.337 1.00 94.94 C \\\\nATOM 1052 CD GLN A 128 -24.500 3.481 6.375 1.00 94.94 C \\\\nATOM 1053 NE2 GLN A 128 -24.954 2.326 5.934 1.00 94.94 N \\\\nATOM 1054 OE1 GLN A 128 -25.037 4.517 6.017 1.00 94.94 O \\\\nATOM 1055 N ARG A 129 -20.128 2.999 8.271 1.00 93.24 N \\\\nATOM 1056 CA ARG A 129 -19.017 2.345 7.577 1.00 93.24 C \\\\nATOM 1057 C ARG A 129 -19.354 2.248 6.093 1.00 93.24 C \\\\nATOM 1058 CB ARG A 129 -18.701 0.979 8.201 1.00 93.24 C \\\\nATOM 1059 O ARG A 129 -20.494 1.964 5.745 1.00 93.24 O \\\\nATOM 1060 CG ARG A 129 -17.357 0.430 7.701 1.00 93.24 C \\\\nATOM 1061 CD ARG A 129 -17.001 -0.874 8.416 1.00 93.24 C \\\\nATOM 1062 NE ARG A 129 -15.580 -1.217 8.225 1.00 93.24 N \\\\nATOM 1063 NH1 ARG A 129 -15.545 -3.069 9.565 1.00 93.24 N \\\\nATOM 1064 NH2 ARG A 129 -13.654 -2.316 8.685 1.00 93.24 N \\\\nATOM 1065 CZ ARG A 129 -14.937 -2.199 8.816 1.00 93.24 C \\\\nATOM 1066 N VAL A 130 -18.379 2.493 5.228 1.00 90.59 N \\\\nATOM 1067 CA VAL A 130 -18.525 2.254 3.792 1.00 90.59 C \\\\nATOM 1068 C VAL A 130 -18.584 0.743 3.573 1.00 90.59 C \\\\nATOM 1069 CB VAL A 130 -17.388 2.919 2.995 1.00 90.59 C \\\\nATOM 1070 O VAL A 130 -17.615 0.034 3.834 1.00 90.59 O \\\\nATOM 1071 CG1 VAL A 130 -17.556 2.671 1.492 1.00 90.59 C \\\\nATOM 1072 CG2 VAL A 130 -17.383 4.441 3.214 1.00 90.59 C \\\\nATOM 1073 N GLU A 131 -19.744 0.256 3.146 1.00 83.73 N \\\\nATOM 1074 CA GLU A 131 -19.983 -1.153 2.835 1.00 83.73 C \\\\nATOM 1075 C GLU A 131 -19.492 -1.473 1.415 1.00 83.73 C \\\\nATOM 1076 CB GLU A 131 -21.480 -1.470 3.027 1.00 83.73 C \\\\nATOM 1077 O GLU A 131 -19.639 -0.659 0.501 1.00 83.73 O \\\\nATOM 1078 CG GLU A 131 -21.875 -1.449 4.519 1.00 83.73 C \\\\nATOM 1079 CD GLU A 131 -23.394 -1.409 4.770 1.00 83.73 C \\\\nATOM 1080 OE1 GLU A 131 -23.785 -0.811 5.806 1.00 83.73 O \\\\nATOM 1081 OE2 GLU A 131 -24.150 -1.953 3.938 1.00 83.73 O \\\\nATOM 1082 N THR A 132 -18.902 -2.655 1.219 1.00 81.31 N \\\\nATOM 1083 CA THR A 132 -18.564 -3.156 -0.121 1.00 81.31 C \\\\nATOM 1084 C THR A 132 -19.844 -3.639 -0.803 1.00 81.31 C \\\\nATOM 1085 CB THR A 132 -17.508 -4.271 -0.069 1.00 81.31 C \\\\nATOM 1086 O THR A 132 -20.510 -4.522 -0.257 1.00 81.31 O \\\\nATOM 1087 CG2 THR A 132 -17.101 -4.782 -1.451 1.00 81.31 C \\\\nATOM 1088 OG1 THR A 132 -16.328 -3.776 0.523 1.00 81.31 O \\\\nATOM 1089 N PRO A 133 -20.218 -3.090 -1.974 1.00 82.14 N \\\\nATOM 1090 CA PRO A 133 -21.417 -3.512 -2.676 1.00 82.14 C \\\\nATOM 1091 C PRO A 133 -21.256 -4.949 -3.177 1.00 82.14 C \\\\nATOM 1092 CB PRO A 133 -21.596 -2.513 -3.821 1.00 82.14 C \\\\nATOM 1093 O PRO A 133 -20.198 -5.332 -3.680 1.00 82.14 O \\\\nATOM 1094 CG PRO A 133 -20.167 -2.064 -4.130 1.00 82.14 C \\\\nATOM 1095 CD PRO A 133 -19.492 -2.105 -2.762 1.00 82.14 C \\\\nATOM 1096 N VAL A 134 -22.324 -5.742 -3.076 1.00 84.73 N \\\\nATOM 1097 CA VAL A 134 -22.350 -7.095 -3.640 1.00 84.73 C \\\\nATOM 1098 C VAL A 134 -22.305 -6.989 -5.163 1.00 84.73 C \\\\nATOM 1099 CB VAL A 134 -23.578 -7.896 -3.166 1.00 84.73 C \\\\nATOM 1100 O VAL A 134 -23.174 -6.370 -5.777 1.00 84.73 O \\\\nATOM 1101 CG1 VAL A 134 -23.554 -9.328 -3.718 1.00 84.73 C \\\\nATOM 1102 CG2 VAL A 134 -23.620 -7.990 -1.634 1.00 84.73 C \\\\nATOM 1103 N LEU A 135 -21.278 -7.581 -5.769 1.00 89.09 N \\\\nATOM 1104 CA LEU A 135 -21.108 -7.609 -7.219 1.00 89.09 C \\\\nATOM 1105 C LEU A 135 -21.987 -8.724 -7.819 1.00 89.09 C \\\\nATOM 1106 CB LEU A 135 -19.617 -7.789 -7.561 1.00 89.09 C \\\\nATOM 1107 O LEU A 135 -21.986 -9.837 -7.283 1.00 89.09 O \\\\nATOM 1108 CG LEU A 135 -18.693 -6.691 -6.997 1.00 89.09 C \\\\nATOM 1109 CD1 LEU A 135 -17.229 -7.061 -7.208 1.00 89.09 C \\\\nATOM 1110 CD2 LEU A 135 -18.944 -5.332 -7.652 1.00 89.09 C \\\\nATOM 1111 N PRO A 136 -22.738 -8.465 -8.907 1.00 88.64 N \\\\nATOM 1112 CA PRO A 136 -23.542 -9.495 -9.559 1.00 88.64 C \\\\nATOM 1113 C PRO A 136 -22.634 -10.566 -10.189 1.00 88.64 C \\\\nATOM 1114 CB PRO A 136 -24.372 -8.757 -10.614 1.00 88.64 C \\\\nATOM 1115 O PRO A 136 -21.542 -10.229 -10.650 1.00 88.64 O \\\\nATOM 1116 CG PRO A 136 -23.484 -7.567 -10.984 1.00 88.64 C \\\\nATOM 1117 CD PRO A 136 -22.802 -7.219 -9.660 1.00 88.64 C \\\\nATOM 1118 N PRO A 137 -23.050 -11.845 -10.241 1.00 90.23 N \\\\nATOM 1119 CA PRO A 137 -22.293 -12.873 -10.945 1.00 90.23 C \\\\nATOM 1120 C PRO A 137 -22.248 -12.582 -12.449 1.00 90.23 C \\\\nATOM 1121 CB PRO A 137 -23.010 -14.193 -10.650 1.00 90.23 C \\\\nATOM 1122 O PRO A 137 -23.247 -12.178 -13.044 1.00 90.23 O \\\\nATOM 1123 CG PRO A 137 -24.458 -13.757 -10.418 1.00 90.23 C \\\\nATOM 1124 CD PRO A 137 -24.311 -12.385 -9.756 1.00 90.23 C \\\\nATOM 1125 N VAL A 138 -21.102 -12.848 -13.072 1.00 90.43 N \\\\nATOM 1126 CA VAL A 138 -20.956 -12.812 -14.533 1.00 90.43 C \\\\nATOM 1127 C VAL A 138 -21.520 -14.113 -15.097 1.00 90.43 C \\\\nATOM 1128 CB VAL A 138 -19.483 -12.596 -14.923 1.00 90.43 C \\\\nATOM 1129 O VAL A 138 -21.149 -15.188 -14.634 1.00 90.43 O \\\\nATOM 1130 CG1 VAL A 138 -19.244 -12.761 -16.426 1.00 90.43 C \\\\nATOM 1131 CG2 VAL A 138 -19.033 -11.184 -14.531 1.00 90.43 C \\\\nATOM 1132 N LEU A 139 -22.432 -14.030 -16.064 1.00 90.13 N \\\\nATOM 1133 CA LEU A 139 -23.028 -15.201 -16.710 1.00 90.13 C \\\\nATOM 1134 C LEU A 139 -22.212 -15.571 -17.950 1.00 90.13 C \\\\nATOM 1135 CB LEU A 139 -24.497 -14.911 -17.070 1.00 90.13 C \\\\nATOM 1136 O LEU A 139 -22.111 -14.764 -18.870 1.00 90.13 O \\\\nATOM 1137 CG LEU A 139 -25.419 -14.571 -15.886 1.00 90.13 C \\\\nATOM 1138 CD1 LEU A 139 -26.852 -14.393 -16.388 1.00 90.13 C \\\\nATOM 1139 CD2 LEU A 139 -25.424 -15.658 -14.809 1.00 90.13 C \\\\nATOM 1140 N VAL A 140 -21.646 -16.777 -17.976 1.00 86.83 N \\\\nATOM 1141 CA VAL A 140 -20.816 -17.263 -19.086 1.00 86.83 C \\\\nATOM 1142 C VAL A 140 -21.594 -18.289 -19.916 1.00 86.83 C \\\\nATOM 1143 CB VAL A 140 -19.483 -17.841 -18.578 1.00 86.83 C \\\\nATOM 1144 O VAL A 140 -22.031 -19.297 -19.353 1.00 86.83 O \\\\nATOM 1145 CG1 VAL A 140 -18.603 -18.256 -19.760 1.00 86.83 C \\\\nATOM 1146 CG2 VAL A 140 -18.706 -16.789 -17.774 1.00 86.83 C \\\\nATOM 1147 N PRO A 141 -21.784 -18.080 -21.233 1.00 80.27 N \\\\nATOM 1148 CA PRO A 141 -22.358 -19.094 -22.111 1.00 80.27 C \\\\nATOM 1149 C PRO A 141 -21.443 -20.313 -22.197 1.00 80.27 C \\\\nATOM 1150 CB PRO A 141 -22.534 -18.428 -23.485 1.00 80.27 C \\\\nATOM 1151 O PRO A 141 -20.263 -20.186 -22.524 1.00 80.27 O \\\\nATOM 1152 CG PRO A 141 -22.470 -16.930 -23.190 1.00 80.27 C \\\\nATOM 1153 CD PRO A 141 -21.543 -16.855 -21.981 1.00 80.27 C \\\\nATOM 1154 N ARG A 142 -21.981 -21.514 -21.970 1.00 69.52 N \\\\nATOM 1155 CA ARG A 142 -21.269 -22.736 -22.351 1.00 69.52 C \\\\nATOM 1156 C ARG A 142 -21.185 -22.821 -23.872 1.00 69.52 C \\\\nATOM 1157 CB ARG A 142 -21.953 -23.967 -21.748 1.00 69.52 C \\\\nATOM 1158 O ARG A 142 -22.206 -22.891 -24.551 1.00 69.52 O \\\\nATOM 1159 CG ARG A 142 -21.631 -24.061 -20.254 1.00 69.52 C \\\\nATOM 1160 CD ARG A 142 -22.346 -25.257 -19.638 1.00 69.52 C \\\\nATOM 1161 NE ARG A 142 -21.928 -25.454 -18.243 1.00 69.52 N \\\\nATOM 1162 NH1 ARG A 142 -23.569 -26.951 -17.623 1.00 69.52 N \\\\nATOM 1163 NH2 ARG A 142 -21.996 -26.344 -16.175 1.00 69.52 N \\\\nATOM 1164 CZ ARG A 142 -22.504 -26.251 -17.367 1.00 69.52 C \\\\nATOM 1165 N HIS A 143 -19.965 -22.851 -24.403 1.00 60.13 N \\\\nATOM 1166 CA HIS A 143 -19.725 -23.115 -25.818 1.00 60.13 C \\\\nATOM 1167 C HIS A 143 -20.074 -24.569 -26.163 1.00 60.13 C \\\\nATOM 1168 CB HIS A 143 -18.268 -22.792 -26.187 1.00 60.13 C \\\\nATOM 1169 O HIS A 143 -19.233 -25.460 -26.058 1.00 60.13 O \\\\nATOM 1170 CG HIS A 143 -17.987 -21.319 -26.313 1.00 60.13 C \\\\nATOM 1171 CD2 HIS A 143 -17.154 -20.573 -25.523 1.00 60.13 C \\\\nATOM 1172 ND1 HIS A 143 -18.492 -20.479 -27.280 1.00 60.13 N \\\\nATOM 1173 CE1 HIS A 143 -17.978 -19.255 -27.072 1.00 60.13 C \\\\nATOM 1174 NE2 HIS A 143 -17.155 -19.264 -26.014 1.00 60.13 N \\\\nATOM 1175 N THR A 144 -21.307 -24.802 -26.609 1.00 49.08 N \\\\nATOM 1176 CA THR A 144 -21.659 -25.991 -27.399 1.00 49.08 C \\\\nATOM 1177 C THR A 144 -21.462 -25.753 -28.894 1.00 49.08 C \\\\nATOM 1178 CB THR A 144 -23.084 -26.500 -27.108 1.00 49.08 C \\\\nATOM 1179 O THR A 144 -20.954 -26.644 -29.567 1.00 49.08 O \\\\nATOM 1180 CG2 THR A 144 -23.051 -27.644 -26.096 1.00 49.08 C \\\\nATOM 1181 OG1 THR A 144 -23.908 -25.493 -26.561 1.00 49.08 O \\\\nATOM 1182 N GLU A 145 -21.785 -24.563 -29.417 1.00 43.90 N \\\\nATOM 1183 CA GLU A 145 -21.641 -24.222 -30.844 1.00 43.90 C \\\\nATOM 1184 C GLU A 145 -21.170 -22.762 -31.027 1.00 43.90 C \\\\nATOM 1185 CB GLU A 145 -22.952 -24.520 -31.606 1.00 43.90 C \\\\nATOM 1186 O GLU A 145 -21.480 -21.888 -30.216 1.00 43.90 O \\\\nATOM 1187 CG GLU A 145 -23.310 -26.023 -31.560 1.00 43.90 C \\\\nATOM 1188 CD GLU A 145 -24.548 -26.438 -32.366 1.00 43.90 C \\\\nATOM 1189 OE1 GLU A 145 -24.808 -27.663 -32.400 1.00 43.90 O \\\\nATOM 1190 OE2 GLU A 145 -25.231 -25.551 -32.922 1.00 43.90 O \\\\nATOM 1191 N ILE A 146 -20.371 -22.501 -32.070 1.00 47.79 N \\\\nATOM 1192 CA ILE A 146 -19.771 -21.185 -32.364 1.00 47.79 C \\\\nATOM 1193 C ILE A 146 -20.657 -20.445 -33.383 1.00 47.79 C \\\\nATOM 1194 CB ILE A 146 -18.323 -21.349 -32.905 1.00 47.79 C \\\\nATOM 1195 O ILE A 146 -20.850 -20.977 -34.478 1.00 47.79 O \\\\nATOM 1196 CG1 ILE A 146 -17.401 -22.045 -31.874 1.00 47.79 C \\\\nATOM 1197 CG2 ILE A 146 -17.724 -19.987 -33.308 1.00 47.79 C \\\\nATOM 1198 CD1 ILE A 146 -16.042 -22.481 -32.443 1.00 47.79 C \\\\nATOM 1199 N PRO A 147 -21.147 -19.220 -33.102 1.00 49.95 N \\\\nATOM 1200 CA PRO A 147 -21.773 -18.379 -34.121 1.00 49.95 C \\\\nATOM 1201 C PRO A 147 -20.759 -18.029 -35.219 1.00 49.95 C \\\\nATOM 1202 CB PRO A 147 -22.294 -17.133 -33.392 1.00 49.95 C \\\\nATOM 1203 O PRO A 147 -19.681 -17.514 -34.929 1.00 49.95 O \\\\nATOM 1204 CG PRO A 147 -22.374 -17.575 -31.931 1.00 49.95 C \\\\nATOM 1205 CD PRO A 147 -21.217 -18.565 -31.807 1.00 49.95 C \\\\nATOM 1206 N ALA A 148 -21.093 -18.327 -36.476 1.00 50.53 N \\\\nATOM 1207 CA ALA A 148 -20.153 -18.237 -37.599 1.00 50.53 C \\\\nATOM 1208 C ALA A 148 -19.879 -16.803 -38.099 1.00 50.53 C \\\\nATOM 1209 CB ALA A 148 -20.670 -19.141 -38.724 1.00 50.53 C \\\\nATOM 1210 O ALA A 148 -18.933 -16.601 -38.856 1.00 50.53 O \\\\nATOM 1211 N GLU A 149 -20.677 -15.819 -37.678 1.00 41.11 N \\\\nATOM 1212 CA GLU A 149 -20.536 -14.413 -38.062 1.00 41.11 C \\\\nATOM 1213 C GLU A 149 -20.661 -13.519 -36.822 1.00 41.11 C \\\\nATOM 1214 CB GLU A 149 -21.581 -14.032 -39.128 1.00 41.11 C \\\\nATOM 1215 O GLU A 149 -21.689 -13.507 -36.145 1.00 41.11 O \\\\nATOM 1216 CG GLU A 149 -21.326 -14.731 -40.475 1.00 41.11 C \\\\nATOM 1217 CD GLU A 149 -22.336 -14.338 -41.566 1.00 41.11 C \\\\nATOM 1218 OE1 GLU A 149 -21.917 -14.275 -42.745 1.00 41.11 O \\\\nATOM 1219 OE2 GLU A 149 -23.526 -14.141 -41.230 1.00 41.11 O \\\\nATOM 1220 N PHE A 150 -19.607 -12.752 -36.542 1.00 50.90 N \\\\nATOM 1221 CA PHE A 150 -19.629 -11.622 -35.614 1.00 50.90 C \\\\nATOM 1222 C PHE A 150 -19.395 -10.328 -36.409 1.00 50.90 C \\\\nATOM 1223 CB PHE A 150 -18.581 -11.808 -34.505 1.00 50.90 C \\\\nATOM 1224 O PHE A 150 -18.740 -10.377 -37.456 1.00 50.90 O \\\\nATOM 1225 CG PHE A 150 -18.997 -12.783 -33.417 1.00 50.90 C \\\\nATOM 1226 CD1 PHE A 150 -19.693 -12.318 -32.284 1.00 50.90 C \\\\nATOM 1227 CD2 PHE A 150 -18.701 -14.154 -33.536 1.00 50.90 C \\\\nATOM 1228 CE1 PHE A 150 -20.083 -13.215 -31.273 1.00 50.90 C \\\\nATOM 1229 CE2 PHE A 150 -19.093 -15.053 -32.528 1.00 50.90 C \\\\nATOM 1230 CZ PHE A 150 -19.783 -14.584 -31.395 1.00 50.90 C \\\\nATOM 1231 N PRO A 151 -19.893 -9.167 -35.939 1.00 45.48 N \\\\nATOM 1232 CA PRO A 151 -19.538 -7.879 -36.527 1.00 45.48 C \\\\nATOM 1233 C PRO A 151 -18.012 -7.690 -36.531 1.00 45.48 C \\\\nATOM 1234 CB PRO A 151 -20.222 -6.811 -35.664 1.00 45.48 C \\\\nATOM 1235 O PRO A 151 -17.342 -8.232 -35.645 1.00 45.48 O \\\\nATOM 1236 CG PRO A 151 -21.324 -7.575 -34.931 1.00 45.48 C \\\\nATOM 1237 CD PRO A 151 -20.732 -8.972 -34.769 1.00 45.48 C \\\\nATOM 1238 N PRO A 152 -17.448 -6.916 -37.477 1.00 43.35 N \\\\nATOM 1239 CA PRO A 152 -16.029 -6.596 -37.439 1.00 43.35 C \\\\nATOM 1240 C PRO A 152 -15.691 -5.935 -36.098 1.00 43.35 C \\\\nATOM 1241 CB PRO A 152 -15.767 -5.682 -38.642 1.00 43.35 C \\\\nATOM 1242 O PRO A 152 -16.322 -4.956 -35.703 1.00 43.35 O \\\\nATOM 1243 CG PRO A 152 -17.138 -5.077 -38.950 1.00 43.35 C \\\\nATOM 1244 CD PRO A 152 -18.120 -6.171 -38.530 1.00 43.35 C \\\\nATOM 1245 N LEU A 153 -14.708 -6.500 -35.396 1.00 46.99 N \\\\nATOM 1246 CA LEU A 153 -14.107 -5.858 -34.233 1.00 46.99 C \\\\nATOM 1247 C LEU A 153 -13.436 -4.565 -34.703 1.00 46.99 C \\\\nATOM 1248 CB LEU A 153 -13.072 -6.804 -33.587 1.00 46.99 C \\\\nATOM 1249 O LEU A 153 -12.665 -4.599 -35.664 1.00 46.99 O \\\\nATOM 1250 CG LEU A 153 -13.670 -8.031 -32.874 1.00 46.99 C \\\\nATOM 1251 CD1 LEU A 153 -12.566 -9.043 -32.557 1.00 46.99 C \\\\nATOM 1252 CD2 LEU A 153 -14.346 -7.649 -31.554 1.00 46.99 C \\\\nATOM 1253 N ASP A 154 -13.695 -3.453 -34.013 1.00 44.28 N \\\\nATOM 1254 CA ASP A 154 -12.870 -2.256 -34.164 1.00 44.28 C \\\\nATOM 1255 C ASP A 154 -11.413 -2.634 -33.881 1.00 44.28 C \\\\nATOM 1256 CB ASP A 154 -13.326 -1.135 -33.215 1.00 44.28 C \\\\nATOM 1257 O ASP A 154 -11.113 -3.281 -32.870 1.00 44.28 O \\\\nATOM 1258 CG ASP A 154 -14.562 -0.385 -33.716 1.00 44.28 C \\\\nATOM 1259 OD1 ASP A 154 -14.599 -0.065 -34.926 1.00 44.28 O \\\\nATOM 1260 OD2 ASP A 154 -15.441 -0.101 -32.871 1.00 44.28 O \\\\nATOM 1261 N ASP A 155 -10.504 -2.262 -34.786 1.00 39.25 N \\\\nATOM 1262 CA ASP A 155 -9.109 -2.671 -34.676 1.00 39.25 C \\\\nATOM 1263 C ASP A 155 -8.376 -1.873 -33.589 1.00 39.25 C \\\\nATOM 1264 CB ASP A 155 -8.374 -2.672 -36.023 1.00 39.25 C \\\\nATOM 1265 O ASP A 155 -7.690 -0.873 -33.821 1.00 39.25 O \\\\nATOM 1266 CG ASP A 155 -6.969 -3.266 -35.845 1.00 39.25 C \\\\nATOM 1267 OD1 ASP A 155 -6.731 -3.949 -34.821 1.00 39.25 O \\\\nATOM 1268 OD2 ASP A 155 -6.084 -3.012 -36.687 1.00 39.25 O \\\\nATOM 1269 N TYR A 156 -8.500 -2.367 -32.362 1.00 43.30 N \\\\nATOM 1270 CA TYR A 156 -7.770 -1.886 -31.202 1.00 43.30 C \\\\nATOM 1271 C TYR A 156 -6.262 -2.222 -31.252 1.00 43.30 C \\\\nATOM 1272 CB TYR A 156 -8.485 -2.362 -29.921 1.00 43.30 C \\\\nATOM 1273 O TYR A 156 -5.565 -1.899 -30.285 1.00 43.30 O \\\\nATOM 1274 CG TYR A 156 -9.726 -1.555 -29.566 1.00 43.30 C \\\\nATOM 1275 CD1 TYR A 156 -9.599 -0.300 -28.937 1.00 43.30 C \\\\nATOM 1276 CD2 TYR A 156 -11.012 -2.049 -29.857 1.00 43.30 C \\\\nATOM 1277 CE1 TYR A 156 -10.733 0.470 -28.621 1.00 43.30 C \\\\nATOM 1278 CE2 TYR A 156 -12.154 -1.294 -29.526 1.00 43.30 C \\\\nATOM 1279 OH TYR A 156 -13.120 0.694 -28.593 1.00 43.30 O \\\\nATOM 1280 CZ TYR A 156 -12.018 -0.032 -28.914 1.00 43.30 C \\\\nATOM 1281 N SER A 157 -5.703 -2.776 -32.343 1.00 44.03 N \\\\nATOM 1282 CA SER A 157 -4.243 -2.892 -32.529 1.00 44.03 C \\\\nATOM 1283 C SER A 157 -3.537 -1.535 -32.392 1.00 44.03 C \\\\nATOM 1284 CB SER A 157 -3.889 -3.535 -33.881 1.00 44.03 C \\\\nATOM 1285 O SER A 157 -2.504 -1.435 -31.732 1.00 44.03 O \\\\nATOM 1286 OG SER A 157 -4.039 -2.628 -34.955 1.00 44.03 O \\\\nATOM 1287 N HIS A 158 -4.160 -0.458 -32.880 1.00 38.34 N \\\\nATOM 1288 CA HIS A 158 -3.667 0.916 -32.739 1.00 38.34 C \\\\nATOM 1289 C HIS A 158 -3.891 1.533 -31.347 1.00 38.34 C \\\\nATOM 1290 CB HIS A 158 -4.280 1.774 -33.850 1.00 38.34 C \\\\nATOM 1291 O HIS A 158 -3.365 2.606 -31.059 1.00 38.34 O \\\\nATOM 1292 CG HIS A 158 -3.831 1.351 -35.226 1.00 38.34 C \\\\nATOM 1293 CD2 HIS A 158 -4.630 1.066 -36.301 1.00 38.34 C \\\\nATOM 1294 ND1 HIS A 158 -2.527 1.162 -35.629 1.00 38.34 N \\\\nATOM 1295 CE1 HIS A 158 -2.543 0.778 -36.915 1.00 38.34 C \\\\nATOM 1296 NE2 HIS A 158 -3.798 0.739 -37.379 1.00 38.34 N \\\\nATOM 1297 N SER A 159 -4.625 0.858 -30.456 1.00 38.83 N \\\\nATOM 1298 CA SER A 159 -4.744 1.260 -29.046 1.00 38.83 C \\\\nATOM 1299 C SER A 159 -3.651 0.669 -28.154 1.00 38.83 C \\\\nATOM 1300 CB SER A 159 -6.123 0.917 -28.499 1.00 38.83 C \\\\nATOM 1301 O SER A 159 -3.557 1.043 -26.982 1.00 38.83 O \\\\nATOM 1302 OG SER A 159 -6.218 -0.454 -28.156 1.00 38.83 O \\\\nATOM 1303 N ILE A 160 -2.822 -0.242 -28.689 1.00 40.21 N \\\\nATOM 1304 CA ILE A 160 -1.624 -0.744 -28.015 1.00 40.21 C \\\\nATOM 1305 C ILE A 160 -0.648 0.430 -27.888 1.00 40.21 C \\\\nATOM 1306 CB ILE A 160 -0.969 -1.918 -28.780 1.00 40.21 C \\\\nATOM 1307 O ILE A 160 -0.074 0.861 -28.888 1.00 40.21 O \\\\nATOM 1308 CG1 ILE A 160 -1.959 -3.092 -28.956 1.00 40.21 C \\\\nATOM 1309 CG2 ILE A 160 0.289 -2.393 -28.019 1.00 40.21 C \\\\nATOM 1310 CD1 ILE A 160 -1.440 -4.208 -29.872 1.00 40.21 C \\\\nATOM 1311 N PRO A 161 -0.412 0.962 -26.681 1.00 43.58 N \\\\nATOM 1312 CA PRO A 161 0.552 2.023 -26.524 1.00 43.58 C \\\\nATOM 1313 C PRO A 161 1.932 1.384 -26.370 1.00 43.58 C \\\\nATOM 1314 CB PRO A 161 0.068 2.791 -25.297 1.00 43.58 C \\\\nATOM 1315 O PRO A 161 2.152 0.600 -25.449 1.00 43.58 O \\\\nATOM 1316 CG PRO A 161 -0.750 1.782 -24.475 1.00 43.58 C \\\\nATOM 1317 CD PRO A 161 -0.924 0.562 -25.378 1.00 43.58 C \\\\nATOM 1318 N GLU A 162 2.907 1.787 -27.186 1.00 51.97 N \\\\nATOM 1319 CA GLU A 162 4.313 1.330 -27.096 1.00 51.97 C \\\\nATOM 1320 C GLU A 162 4.959 1.568 -25.708 1.00 51.97 C \\\\nATOM 1321 CB GLU A 162 5.148 2.041 -28.171 1.00 51.97 C \\\\nATOM 1322 O GLU A 162 6.053 1.091 -25.403 1.00 51.97 O \\\\nATOM 1323 CG GLU A 162 4.705 1.733 -29.611 1.00 51.97 C \\\\nATOM 1324 CD GLU A 162 5.627 2.428 -30.624 1.00 51.97 C \\\\nATOM 1325 OE1 GLU A 162 6.049 1.755 -31.589 1.00 51.97 O \\\\nATOM 1326 OE2 GLU A 162 5.927 3.624 -30.395 1.00 51.97 O \\\\nATOM 1327 N ASN A 163 4.263 2.268 -24.805 1.00 55.17 N \\\\nATOM 1328 CA ASN A 163 4.623 2.384 -23.398 1.00 55.17 C \\\\nATOM 1329 C ASN A 163 4.496 1.090 -22.566 1.00 55.17 C \\\\nATOM 1330 CB ASN A 163 3.936 3.622 -22.785 1.00 55.17 C \\\\nATOM 1331 O ASN A 163 4.902 1.119 -21.402 1.00 55.17 O \\\\nATOM 1332 CG ASN A 163 2.443 3.565 -22.528 1.00 55.17 C \\\\nATOM 1333 ND2 ASN A 163 1.793 4.704 -22.602 1.00 55.17 N \\\\nATOM 1334 OD1 ASN A 163 1.852 2.571 -22.154 1.00 55.17 O \\\\nATOM 1335 N THR A 164 4.011 -0.025 -23.135 1.00 50.75 N \\\\nATOM 1336 CA THR A 164 3.756 -1.293 -22.421 1.00 50.75 C \\\\nATOM 1337 C THR A 164 4.792 -2.411 -22.609 1.00 50.75 C \\\\nATOM 1338 CB THR A 164 2.345 -1.846 -22.708 1.00 50.75 C \\\\nATOM 1339 O THR A 164 4.489 -3.547 -22.245 1.00 50.75 O \\\\nATOM 1340 CG2 THR A 164 1.248 -0.843 -22.368 1.00 50.75 C \\\\nATOM 1341 OG1 THR A 164 2.175 -2.204 -24.057 1.00 50.75 O \\\\nATOM 1342 N ASN A 165 5.985 -2.158 -23.162 1.00 46.01 N \\\\nATOM 1343 CA ASN A 165 6.958 -3.231 -23.437 1.00 46.01 C \\\\nATOM 1344 C ASN A 165 7.416 -3.989 -22.172 1.00 46.01 C \\\\nATOM 1345 CB ASN A 165 8.159 -2.701 -24.250 1.00 46.01 C \\\\nATOM 1346 O ASN A 165 8.296 -3.539 -21.434 1.00 46.01 O \\\\nATOM 1347 CG ASN A 165 7.840 -2.535 -25.727 1.00 46.01 C \\\\nATOM 1348 ND2 ASN A 165 8.836 -2.447 -26.576 1.00 46.01 N \\\\nATOM 1349 OD1 ASN A 165 6.696 -2.500 -26.135 1.00 46.01 O \\\\nATOM 1350 N PHE A 166 6.859 -5.189 -21.983 1.00 39.23 N \\\\nATOM 1351 CA PHE A 166 7.439 -6.247 -21.160 1.00 39.23 C \\\\nATOM 1352 C PHE A 166 8.686 -6.815 -21.859 1.00 39.23 C \\\\nATOM 1353 CB PHE A 166 6.422 -7.383 -20.959 1.00 39.23 C \\\\nATOM 1354 O PHE A 166 8.648 -7.028 -23.072 1.00 39.23 O \\\\nATOM 1355 CG PHE A 166 5.298 -7.094 -19.983 1.00 39.23 C \\\\nATOM 1356 CD1 PHE A 166 5.477 -7.366 -18.612 1.00 39.23 C \\\\nATOM 1357 CD2 PHE A 166 4.061 -6.601 -20.440 1.00 39.23 C \\\\nATOM 1358 CE1 PHE A 166 4.427 -7.142 -17.704 1.00 39.23 C \\\\nATOM 1359 CE2 PHE A 166 3.004 -6.398 -19.533 1.00 39.23 C \\\\nATOM 1360 CZ PHE A 166 3.188 -6.666 -18.165 1.00 39.23 C \\\\nATOM 1361 N PRO A 167 9.773 -7.129 -21.133 1.00 38.71 N \\\\nATOM 1362 CA PRO A 167 10.925 -7.804 -21.715 1.00 38.71 C \\\\nATOM 1363 C PRO A 167 10.655 -9.311 -21.872 1.00 38.71 C \\\\nATOM 1364 CB PRO A 167 12.089 -7.465 -20.778 1.00 38.71 C \\\\nATOM 1365 O PRO A 167 11.086 -10.120 -21.052 1.00 38.71 O \\\\nATOM 1366 CG PRO A 167 11.413 -7.359 -19.411 1.00 38.71 C \\\\nATOM 1367 CD PRO A 167 10.026 -6.799 -19.738 1.00 38.71 C \\\\nATOM 1368 N ALA A 168 9.985 -9.694 -22.961 1.00 35.78 N \\\\nATOM 1369 CA ALA A 168 10.348 -10.935 -23.644 1.00 35.78 C \\\\nATOM 1370 C ALA A 168 11.684 -10.665 -24.361 1.00 35.78 C \\\\nATOM 1371 CB ALA A 168 9.221 -11.358 -24.591 1.00 35.78 C \\\\nATOM 1372 O ALA A 168 11.835 -9.631 -25.011 1.00 35.78 O \\\\nATOM 1373 N GLY A 169 12.697 -11.498 -24.123 1.00 29.87 N \\\\nATOM 1374 CA GLY A 169 14.087 -11.107 -24.379 1.00 29.87 C \\\\nATOM 1375 C GLY A 169 14.470 -11.009 -25.859 1.00 29.87 C \\\\nATOM 1376 O GLY A 169 14.032 -11.835 -26.648 1.00 29.87 O \\\\nATOM 1377 N ILE A 170 15.332 -10.035 -26.181 1.00 36.65 N \\\\nATOM 1378 CA ILE A 170 16.510 -10.086 -27.078 1.00 36.65 C \\\\nATOM 1379 C ILE A 170 17.256 -8.728 -26.959 1.00 36.65 C \\\\nATOM 1380 CB ILE A 170 16.148 -10.534 -28.525 1.00 36.65 C \\\\nATOM 1381 O ILE A 170 16.703 -7.734 -26.495 1.00 36.65 O \\\\nATOM 1382 CG1 ILE A 170 16.237 -12.082 -28.648 1.00 36.65 C \\\\nATOM 1383 CG2 ILE A 170 17.054 -9.959 -29.631 1.00 36.65 C \\\\nATOM 1384 CD1 ILE A 170 15.229 -12.665 -29.647 1.00 36.65 C \\\\nATOM 1385 N GLU A 171 18.553 -8.749 -27.253 1.00 33.34 N \\\\nATOM 1386 CA GLU A 171 19.647 -7.827 -26.886 1.00 33.34 C \\\\nATOM 1387 C GLU A 171 19.508 -6.322 -27.262 1.00 33.34 C \\\\nATOM 1388 CB GLU A 171 20.912 -8.384 -27.563 1.00 33.34 C \\\\nATOM 1389 O GLU A 171 18.815 -5.979 -28.219 1.00 33.34 O \\\\nATOM 1390 CG GLU A 171 21.205 -9.850 -27.182 1.00 33.34 C \\\\nATOM 1391 CD GLU A 171 22.413 -10.424 -27.929 1.00 33.34 C \\\\nATOM 1392 OE1 GLU A 171 23.174 -11.173 -27.278 1.00 33.34 O \\\\nATOM 1393 OE2 GLU A 171 22.553 -10.127 -29.136 1.00 33.34 O \\\\nATOM 1394 N PRO A 172 20.211 -5.394 -26.564 1.00 32.49 N \\\\nATOM 1395 CA PRO A 172 20.148 -3.952 -26.836 1.00 32.49 C \\\\nATOM 1396 C PRO A 172 21.300 -3.415 -27.713 1.00 32.49 C \\\\nATOM 1397 CB PRO A 172 20.199 -3.318 -25.443 1.00 32.49 C \\\\nATOM 1398 O PRO A 172 22.469 -3.712 -27.466 1.00 32.49 O \\\\nATOM 1399 CG PRO A 172 21.162 -4.236 -24.683 1.00 32.49 C \\\\nATOM 1400 CD PRO A 172 20.926 -5.616 -25.309 1.00 32.49 C \\\\nATOM 1401 N GLN A 173 21.001 -2.487 -28.635 1.00 36.11 N \\\\nATOM 1402 CA GLN A 173 22.011 -1.656 -29.317 1.00 36.11 C \\\\nATOM 1403 C GLN A 173 21.726 -0.141 -29.211 1.00 36.11 C \\\\nATOM 1404 CB GLN A 173 22.234 -2.115 -30.772 1.00 36.11 C \\\\nATOM 1405 O GLN A 173 20.910 0.426 -29.924 1.00 36.11 O \\\\nATOM 1406 CG GLN A 173 23.064 -3.412 -30.836 1.00 36.11 C \\\\nATOM 1407 CD GLN A 173 23.549 -3.774 -32.240 1.00 36.11 C \\\\nATOM 1408 NE2 GLN A 173 24.380 -4.785 -32.370 1.00 36.11 N \\\\nATOM 1409 OE1 GLN A 173 23.215 -3.168 -33.243 1.00 36.11 O \\\\nATOM 1410 N SER A 174 22.463 0.497 -28.294 1.00 35.78 N \\\\nATOM 1411 CA SER A 174 23.201 1.768 -28.464 1.00 35.78 C \\\\nATOM 1412 C SER A 174 22.584 3.014 -29.161 1.00 35.78 C \\\\nATOM 1413 CB SER A 174 24.544 1.424 -29.129 1.00 35.78 C \\\\nATOM 1414 O SER A 174 22.504 3.069 -30.383 1.00 35.78 O \\\\nATOM 1415 OG SER A 174 24.359 0.851 -30.404 1.00 35.78 O \\\\nATOM 1416 N ASN A 175 22.484 4.104 -28.369 1.00 35.08 N \\\\nATOM 1417 CA ASN A 175 23.258 5.374 -28.501 1.00 35.08 C \\\\nATOM 1418 C ASN A 175 22.610 6.746 -28.897 1.00 35.08 C \\\\nATOM 1419 CB ASN A 175 24.603 5.154 -29.250 1.00 35.08 C \\\\nATOM 1420 O ASN A 175 22.404 7.013 -30.071 1.00 35.08 O \\\\nATOM 1421 CG ASN A 175 25.726 4.615 -28.377 1.00 35.08 C \\\\nATOM 1422 ND2 ASN A 175 26.864 4.315 -28.954 1.00 35.08 N \\\\nATOM 1423 OD1 ASN A 175 25.602 4.449 -27.175 1.00 35.08 O \\\\nATOM 1424 N ILE A 176 22.622 7.684 -27.909 1.00 42.21 N \\\\nATOM 1425 CA ILE A 176 23.071 9.121 -27.980 1.00 42.21 C \\\\nATOM 1426 C ILE A 176 22.116 10.155 -28.683 1.00 42.21 C \\\\nATOM 1427 CB ILE A 176 24.533 9.124 -28.560 1.00 42.21 C \\\\nATOM 1428 O ILE A 176 21.554 9.825 -29.717 1.00 42.21 O \\\\nATOM 1429 CG1 ILE A 176 25.528 8.202 -27.803 1.00 42.21 C \\\\nATOM 1430 CG2 ILE A 176 25.248 10.481 -28.601 1.00 42.21 C \\\\nATOM 1431 CD1 ILE A 176 26.821 7.896 -28.587 1.00 42.21 C \\\\nATOM 1432 N PRO A 177 21.984 11.451 -28.260 1.00 34.10 N \\\\nATOM 1433 CA PRO A 177 21.878 12.076 -26.925 1.00 34.10 C \\\\nATOM 1434 C PRO A 177 20.748 13.164 -26.840 1.00 34.10 C \\\\nATOM 1435 CB PRO A 177 23.238 12.758 -26.772 1.00 34.10 C \\\\nATOM 1436 O PRO A 177 19.832 13.216 -27.651 1.00 34.10 O \\\\nATOM 1437 CG PRO A 177 23.430 13.356 -28.173 1.00 34.10 C \\\\nATOM 1438 CD PRO A 177 22.508 12.528 -29.094 1.00 34.10 C \\\\nATOM 1439 N GLU A 178 20.803 14.056 -25.840 1.00 31.22 N \\\\nATOM 1440 CA GLU A 178 19.766 15.049 -25.493 1.00 31.22 C \\\\nATOM 1441 C GLU A 178 19.873 16.441 -26.160 1.00 31.22 C \\\\nATOM 1442 CB GLU A 178 19.800 15.310 -23.972 1.00 31.22 C \\\\nATOM 1443 O GLU A 178 20.954 17.024 -26.197 1.00 31.22 O \\\\nATOM 1444 CG GLU A 178 19.939 14.061 -23.097 1.00 31.22 C \\\\nATOM 1445 CD GLU A 178 19.667 14.394 -21.630 1.00 31.22 C \\\\nATOM 1446 OE1 GLU A 178 18.475 14.276 -21.249 1.00 31.22 O \\\\nATOM 1447 OE2 GLU A 178 20.612 14.760 -20.908 1.00 31.22 O \\\\nATOM 1448 N THR A 179 18.718 17.054 -26.467 1.00 36.45 N \\\\nATOM 1449 CA THR A 179 18.493 18.520 -26.512 1.00 36.45 C \\\\nATOM 1450 C THR A 179 17.057 18.880 -26.052 1.00 36.45 C \\\\nATOM 1451 CB THR A 179 18.724 19.135 -27.909 1.00 36.45 C \\\\nATOM 1452 O THR A 179 16.109 18.175 -26.403 1.00 36.45 O \\\\nATOM 1453 CG2 THR A 179 20.193 19.431 -28.204 1.00 36.45 C \\\\nATOM 1454 OG1 THR A 179 18.255 18.284 -28.926 1.00 36.45 O \\\\nATOM 1455 N PRO A 180 16.865 19.933 -25.227 1.00 38.72 N \\\\nATOM 1456 CA PRO A 180 15.547 20.523 -24.897 1.00 38.72 C \\\\nATOM 1457 C PRO A 180 15.526 22.074 -25.039 1.00 38.72 C \\\\nATOM 1458 CB PRO A 180 15.411 20.132 -23.420 1.00 38.72 C \\\\nATOM 1459 O PRO A 180 16.585 22.664 -25.249 1.00 38.72 O \\\\nATOM 1460 CG PRO A 180 16.821 20.396 -22.876 1.00 38.72 C \\\\nATOM 1461 CD PRO A 180 17.742 20.136 -24.075 1.00 38.72 C \\\\nATOM 1462 N PRO A 181 14.425 22.785 -24.695 1.00 44.75 N \\\\nATOM 1463 CA PRO A 181 12.998 22.573 -24.970 1.00 44.75 C \\\\nATOM 1464 C PRO A 181 12.578 23.642 -26.037 1.00 44.75 C \\\\nATOM 1465 CB PRO A 181 12.406 22.621 -23.564 1.00 44.75 C \\\\nATOM 1466 O PRO A 181 13.211 23.555 -27.088 1.00 44.75 O \\\\nATOM 1467 CG PRO A 181 13.195 23.757 -22.893 1.00 44.75 C \\\\nATOM 1468 CD PRO A 181 14.509 23.832 -23.686 1.00 44.75 C \\\\nATOM 1469 N PRO A 182 11.679 24.667 -25.892 1.00 38.69 N \\\\nATOM 1470 CA PRO A 182 10.580 25.008 -24.958 1.00 38.69 C \\\\nATOM 1471 C PRO A 182 9.177 24.739 -25.580 1.00 38.69 C \\\\nATOM 1472 CB PRO A 182 10.839 26.493 -24.650 1.00 38.69 C \\\\nATOM 1473 O PRO A 182 9.040 23.844 -26.406 1.00 38.69 O \\\\nATOM 1474 CG PRO A 182 11.386 27.063 -25.956 1.00 38.69 C \\\\nATOM 1475 CD PRO A 182 11.791 25.833 -26.773 1.00 38.69 C \\\\nATOM 1476 N GLY A 183 8.136 25.483 -25.169 1.00 30.01 N \\\\nATOM 1477 CA GLY A 183 6.812 25.582 -25.824 1.00 30.01 C \\\\nATOM 1478 C GLY A 183 6.240 27.004 -25.675 1.00 30.01 C \\\\nATOM 1479 O GLY A 183 6.944 27.820 -25.092 1.00 30.01 O \\\\nATOM 1480 N TYR A 184 5.022 27.310 -26.155 1.00 39.51 N \\\\nATOM 1481 CA TYR A 184 4.191 28.473 -25.752 1.00 39.51 C \\\\nATOM 1482 C TYR A 184 2.738 28.354 -26.304 1.00 39.51 C \\\\nATOM 1483 CB TYR A 184 4.832 29.829 -26.159 1.00 39.51 C \\\\nATOM 1484 O TYR A 184 2.514 27.690 -27.308 1.00 39.51 O \\\\nATOM 1485 CG TYR A 184 5.058 30.825 -25.014 1.00 39.51 C \\\\nATOM 1486 CD1 TYR A 184 4.208 31.938 -24.856 1.00 39.51 C \\\\nATOM 1487 CD2 TYR A 184 6.147 30.684 -24.126 1.00 39.51 C \\\\nATOM 1488 CE1 TYR A 184 4.418 32.858 -23.805 1.00 39.51 C \\\\nATOM 1489 CE2 TYR A 184 6.360 31.588 -23.072 1.00 39.51 C \\\\nATOM 1490 OH TYR A 184 5.701 33.561 -21.892 1.00 39.51 O \\\\nATOM 1491 CZ TYR A 184 5.489 32.680 -22.905 1.00 39.51 C \\\\nATOM 1492 N LEU A 185 1.807 28.987 -25.580 1.00 35.19 N \\\\nATOM 1493 CA LEU A 185 0.381 29.350 -25.789 1.00 35.19 C \\\\nATOM 1494 C LEU A 185 -0.415 29.022 -27.091 1.00 35.19 C \\\\nATOM 1495 CB LEU A 185 0.305 30.876 -25.571 1.00 35.19 C \\\\nATOM 1496 O LEU A 185 -0.010 29.385 -28.186 1.00 35.19 O \\\\nATOM 1497 CG LEU A 185 0.771 31.371 -24.187 1.00 35.19 C \\\\nATOM 1498 CD1 LEU A 185 0.821 32.896 -24.155 1.00 35.19 C \\\\nATOM 1499 CD2 LEU A 185 -0.152 30.898 -23.064 1.00 35.19 C \\\\nATOM 1500 N SER A 186 -1.622 28.473 -26.858 1.00 34.39 N \\\\nATOM 1501 CA SER A 186 -2.988 28.878 -27.296 1.00 34.39 C \\\\nATOM 1502 C SER A 186 -3.303 29.479 -28.681 1.00 34.39 C \\\\nATOM 1503 CB SER A 186 -3.534 29.907 -26.294 1.00 34.39 C \\\\nATOM 1504 O SER A 186 -2.736 30.504 -29.031 1.00 34.39 O \\\\nATOM 1505 OG SER A 186 -3.317 29.516 -24.945 1.00 34.39 O \\\\nATOM 1506 N GLU A 187 -4.399 29.001 -29.302 1.00 39.49 N \\\\nATOM 1507 CA GLU A 187 -5.525 29.837 -29.798 1.00 39.49 C \\\\nATOM 1508 C GLU A 187 -6.809 29.001 -30.054 1.00 39.49 C \\\\nATOM 1509 CB GLU A 187 -5.139 30.702 -31.023 1.00 39.49 C \\\\nATOM 1510 O GLU A 187 -6.735 27.781 -30.217 1.00 39.49 O \\\\nATOM 1511 CG GLU A 187 -5.129 32.188 -30.606 1.00 39.49 C \\\\nATOM 1512 CD GLU A 187 -4.650 33.164 -31.695 1.00 39.49 C \\\\nATOM 1513 OE1 GLU A 187 -5.250 34.262 -31.783 1.00 39.49 O \\\\nATOM 1514 OE2 GLU A 187 -3.662 32.854 -32.400 1.00 39.49 O \\\\nATOM 1515 N ASP A 188 -7.981 29.651 -30.011 1.00 34.92 N \\\\nATOM 1516 CA ASP A 188 -9.330 29.047 -29.984 1.00 34.92 C \\\\nATOM 1517 C ASP A 188 -9.981 28.853 -31.376 1.00 34.92 C \\\\nATOM 1518 CB ASP A 188 -10.245 29.934 -29.116 1.00 34.92 C \\\\nATOM 1519 O ASP A 188 -9.538 29.415 -32.378 1.00 34.92 O \\\\nATOM 1520 CG ASP A 188 -9.788 30.022 -27.658 1.00 34.92 C \\\\nATOM 1521 OD1 ASP A 188 -9.987 29.023 -26.931 1.00 34.92 O \\\\nATOM 1522 OD2 ASP A 188 -9.236 31.080 -27.276 1.00 34.92 O \\\\nATOM 1523 N GLY A 189 -11.098 28.109 -31.437 1.00 37.79 N \\\\nATOM 1524 CA GLY A 189 -11.931 27.992 -32.644 1.00 37.79 C \\\\nATOM 1525 C GLY A 189 -13.313 27.363 -32.408 1.00 37.79 C \\\\nATOM 1526 O GLY A 189 -13.435 26.143 -32.331 1.00 37.79 O \\\\nATOM 1527 N GLU A 190 -14.361 28.192 -32.341 1.00 33.29 N \\\\nATOM 1528 CA GLU A 190 -15.779 27.783 -32.283 1.00 33.29 C \\\\nATOM 1529 C GLU A 190 -16.458 27.848 -33.669 1.00 33.29 C \\\\nATOM 1530 CB GLU A 190 -16.569 28.709 -31.334 1.00 33.29 C \\\\nATOM 1531 O GLU A 190 -16.091 28.687 -34.487 1.00 33.29 O \\\\nATOM 1532 CG GLU A 190 -16.107 28.723 -29.870 1.00 33.29 C \\\\nATOM 1533 CD GLU A 190 -17.007 29.639 -29.018 1.00 33.29 C \\\\nATOM 1534 OE1 GLU A 190 -17.574 29.139 -28.019 1.00 33.29 O \\\\nATOM 1535 OE2 GLU A 190 -17.140 30.831 -29.380 1.00 33.29 O \\\\nATOM 1536 N THR A 191 -17.458 26.990 -33.929 1.00 42.71 N \\\\nATOM 1537 CA THR A 191 -18.598 27.103 -34.895 1.00 42.71 C \\\\nATOM 1538 C THR A 191 -19.276 25.716 -35.016 1.00 42.71 C \\\\nATOM 1539 CB THR A 191 -18.207 27.533 -36.336 1.00 42.71 C \\\\nATOM 1540 O THR A 191 -18.584 24.710 -34.902 1.00 42.71 O \\\\nATOM 1541 CG2 THR A 191 -18.196 29.048 -36.589 1.00 42.71 C \\\\nATOM 1542 OG1 THR A 191 -16.938 27.058 -36.710 1.00 42.71 O \\\\nATOM 1543 N SER A 192 -20.579 25.502 -35.263 1.00 40.70 N \\\\nATOM 1544 CA SER A 192 -21.818 26.304 -35.160 1.00 40.70 C \\\\nATOM 1545 C SER A 192 -23.040 25.348 -35.172 1.00 40.70 C \\\\nATOM 1546 CB SER A 192 -21.980 27.261 -36.348 1.00 40.70 C \\\\nATOM 1547 O SER A 192 -22.941 24.232 -35.679 1.00 40.70 O \\\\nATOM 1548 OG SER A 192 -21.283 28.465 -36.112 1.00 40.70 O \\\\nATOM 1549 N ASP A 193 -24.191 25.782 -34.643 1.00 32.70 N \\\\nATOM 1550 CA ASP A 193 -25.446 25.002 -34.558 1.00 32.70 C \\\\nATOM 1551 C ASP A 193 -26.161 24.721 -35.895 1.00 32.70 C \\\\nATOM 1552 CB ASP A 193 -26.463 25.781 -33.704 1.00 32.70 C \\\\nATOM 1553 O ASP A 193 -26.122 25.534 -36.818 1.00 32.70 O \\\\nATOM 1554 CG ASP A 193 -26.155 25.743 -32.216 1.00 32.70 C \\\\nATOM 1555 OD1 ASP A 193 -26.245 24.629 -31.656 1.00 32.70 O \\\\nATOM 1556 OD2 ASP A 193 -25.885 26.830 -31.664 1.00 32.70 O \\\\nATOM 1557 N HIS A 194 -26.991 23.664 -35.917 1.00 43.62 N \\\\nATOM 1558 CA HIS A 194 -28.169 23.580 -36.797 1.00 43.62 C \\\\nATOM 1559 C HIS A 194 -29.393 22.927 -36.111 1.00 43.62 C \\\\nATOM 1560 CB HIS A 194 -27.822 22.876 -38.123 1.00 43.62 C \\\\nATOM 1561 O HIS A 194 -29.395 21.740 -35.792 1.00 43.62 O \\\\nATOM 1562 CG HIS A 194 -27.307 23.818 -39.187 1.00 43.62 C \\\\nATOM 1563 CD2 HIS A 194 -26.093 23.766 -39.821 1.00 43.62 C \\\\nATOM 1564 ND1 HIS A 194 -27.980 24.906 -39.701 1.00 43.62 N \\\\nATOM 1565 CE1 HIS A 194 -27.186 25.497 -40.608 1.00 43.62 C \\\\nATOM 1566 NE2 HIS A 194 -26.036 24.823 -40.740 1.00 43.62 N \\\\nATOM 1567 N GLN A 195 -30.471 23.707 -35.955 1.00 34.38 N \\\\nATOM 1568 CA GLN A 195 -31.841 23.260 -35.637 1.00 34.38 C \\\\nATOM 1569 C GLN A 195 -32.716 23.226 -36.901 1.00 34.38 C \\\\nATOM 1570 CB GLN A 195 -32.523 24.269 -34.690 1.00 34.38 C \\\\nATOM 1571 O GLN A 195 -32.548 24.103 -37.742 1.00 34.38 O \\\\nATOM 1572 CG GLN A 195 -32.220 24.116 -33.198 1.00 34.38 C \\\\nATOM 1573 CD GLN A 195 -32.992 25.136 -32.354 1.00 34.38 C \\\\nATOM 1574 NE2 GLN A 195 -32.890 25.070 -31.046 1.00 34.38 N \\\\nATOM 1575 OE1 GLN A 195 -33.706 26.001 -32.834 1.00 34.38 O \\\\nATOM 1576 N MET A 196 -33.689 22.298 -36.971 1.00 43.58 N \\\\nATOM 1577 CA MET A 196 -34.997 22.344 -37.686 1.00 43.58 C \\\\nATOM 1578 C MET A 196 -35.638 20.930 -37.660 1.00 43.58 C \\\\nATOM 1579 CB MET A 196 -34.835 22.770 -39.167 1.00 43.58 C \\\\nATOM 1580 O MET A 196 -34.898 19.954 -37.655 1.00 43.58 O \\\\nATOM 1581 CG MET A 196 -34.842 24.298 -39.367 1.00 43.58 C \\\\nATOM 1582 SD MET A 196 -36.152 24.997 -40.407 1.00 43.58 S \\\\nATOM 1583 CE MET A 196 -35.694 26.747 -40.262 1.00 43.58 C \\\\nATOM 1584 N ASN A 197 -36.958 20.690 -37.705 1.00 41.11 N \\\\nATOM 1585 CA ASN A 197 -38.153 21.466 -37.322 1.00 41.11 C \\\\nATOM 1586 C ASN A 197 -39.364 20.485 -37.186 1.00 41.11 C \\\\nATOM 1587 CB ASN A 197 -38.439 22.571 -38.361 1.00 41.11 C \\\\nATOM 1588 O ASN A 197 -39.254 19.313 -37.540 1.00 41.11 O \\\\nATOM 1589 CG ASN A 197 -39.298 23.710 -37.834 1.00 41.11 C \\\\nATOM 1590 ND2 ASN A 197 -39.465 24.753 -38.609 1.00 41.11 N \\\\nATOM 1591 OD1 ASN A 197 -39.813 23.690 -36.728 1.00 41.11 O \\\\nATOM 1592 N HIS A 198 -40.511 20.944 -36.673 1.00 40.12 N \\\\nATOM 1593 CA HIS A 198 -41.731 20.157 -36.393 1.00 40.12 C \\\\nATOM 1594 C HIS A 198 -42.478 19.583 -37.619 1.00 40.12 C \\\\nATOM 1595 CB HIS A 198 -42.733 21.089 -35.691 1.00 40.12 C \\\\nATOM 1596 O HIS A 198 -42.436 20.176 -38.696 1.00 40.12 O \\\\nATOM 1597 CG HIS A 198 -42.362 21.505 -34.298 1.00 40.12 C \\\\nATOM 1598 CD2 HIS A 198 -41.690 22.640 -33.929 1.00 40.12 C \\\\nATOM 1599 ND1 HIS A 198 -42.742 20.860 -33.143 1.00 40.12 N \\\\nATOM 1600 CE1 HIS A 198 -42.304 21.586 -32.102 1.00 40.12 C \\\\nATOM 1601 NE2 HIS A 198 -41.659 22.679 -32.531 1.00 40.12 N \\\\nATOM 1602 N SER A 199 -43.319 18.552 -37.397 1.00 44.95 N \\\\nATOM 1603 CA SER A 199 -44.767 18.530 -37.752 1.00 44.95 C \\\\nATOM 1604 C SER A 199 -45.504 17.297 -37.184 1.00 44.95 C \\\\nATOM 1605 CB SER A 199 -45.013 18.600 -39.264 1.00 44.95 C \\\\nATOM 1606 O SER A 199 -44.880 16.278 -36.905 1.00 44.95 O \\\\nATOM 1607 OG SER A 199 -44.858 19.940 -39.677 1.00 44.95 O \\\\nATOM 1608 N MET A 200 -46.827 17.399 -36.996 1.00 45.79 N \\\\nATOM 1609 CA MET A 200 -47.737 16.340 -36.510 1.00 45.79 C \\\\nATOM 1610 C MET A 200 -48.777 15.996 -37.591 1.00 45.79 C \\\\nATOM 1611 CB MET A 200 -48.544 16.849 -35.293 1.00 45.79 C \\\\nATOM 1612 O MET A 200 -49.139 16.913 -38.320 1.00 45.79 O \\\\nATOM 1613 CG MET A 200 -47.745 17.422 -34.119 1.00 45.79 C \\\\nATOM 1614 SD MET A 200 -48.821 18.013 -32.777 1.00 45.79 S \\\\nATOM 1615 CE MET A 200 -47.596 18.699 -31.636 1.00 45.79 C \\\\nATOM 1616 N ASP A 201 -49.331 14.771 -37.623 1.00 46.67 N \\\\nATOM 1617 CA ASP A 201 -50.800 14.576 -37.689 1.00 46.67 C \\\\nATOM 1618 C ASP A 201 -51.266 13.129 -37.369 1.00 46.67 C \\\\nATOM 1619 CB ASP A 201 -51.455 15.079 -38.999 1.00 46.67 C \\\\nATOM 1620 O ASP A 201 -50.450 12.229 -37.159 1.00 46.67 O \\\\nATOM 1621 CG ASP A 201 -52.680 15.954 -38.674 1.00 46.67 C \\\\nATOM 1622 OD1 ASP A 201 -53.380 15.616 -37.687 1.00 46.67 O \\\\nATOM 1623 OD2 ASP A 201 -52.926 16.935 -39.408 1.00 46.67 O \\\\nATOM 1624 N ALA A 202 -52.585 12.935 -37.251 1.00 43.71 N \\\\nATOM 1625 CA ALA A 202 -53.251 11.820 -36.563 1.00 43.71 C \\\\nATOM 1626 C ALA A 202 -53.674 10.601 -37.424 1.00 43.71 C \\\\nATOM 1627 CB ALA A 202 -54.477 12.426 -35.864 1.00 43.71 C \\\\nATOM 1628 O ALA A 202 -53.850 10.694 -38.636 1.00 43.71 O \\\\nATOM 1629 N GLY A 203 -53.959 9.462 -36.762 1.00 40.70 N \\\\nATOM 1630 CA GLY A 203 -54.671 8.322 -37.373 1.00 40.70 C \\\\nATOM 1631 C GLY A 203 -54.584 6.979 -36.622 1.00 40.70 C \\\\nATOM 1632 O GLY A 203 -53.621 6.241 -36.779 1.00 40.70 O \\\\nATOM 1633 N SER A 204 -55.635 6.626 -35.875 1.00 42.76 N \\\\nATOM 1634 CA SER A 204 -55.953 5.263 -35.375 1.00 42.76 C \\\\nATOM 1635 C SER A 204 -57.215 4.749 -36.114 1.00 42.76 C \\\\nATOM 1636 CB SER A 204 -56.175 5.346 -33.854 1.00 42.76 C \\\\nATOM 1637 O SER A 204 -57.909 5.613 -36.658 1.00 42.76 O \\\\nATOM 1638 OG SER A 204 -54.953 5.182 -33.165 1.00 42.76 O \\\\nATOM 1639 N PRO A 205 -57.600 3.440 -36.129 1.00 46.18 N \\\\nATOM 1640 CA PRO A 205 -57.311 2.419 -35.103 1.00 46.18 C \\\\nATOM 1641 C PRO A 205 -57.072 0.946 -35.563 1.00 46.18 C \\\\nATOM 1642 CB PRO A 205 -58.634 2.448 -34.321 1.00 46.18 C \\\\nATOM 1643 O PRO A 205 -57.305 0.567 -36.703 1.00 46.18 O \\\\nATOM 1644 CG PRO A 205 -59.689 2.523 -35.436 1.00 46.18 C \\\\nATOM 1645 CD PRO A 205 -58.931 3.098 -36.637 1.00 46.18 C \\\\nATOM 1646 N ASN A 206 -56.707 0.107 -34.579 1.00 39.37 N \\\\nATOM 1647 CA ASN A 206 -57.019 -1.327 -34.383 1.00 39.37 C \\\\nATOM 1648 C ASN A 206 -57.092 -2.311 -35.573 1.00 39.37 C \\\\nATOM 1649 CB ASN A 206 -58.360 -1.430 -33.622 1.00 39.37 C \\\\nATOM 1650 O ASN A 206 -58.089 -2.336 -36.285 1.00 39.37 O \\\\nATOM 1651 CG ASN A 206 -58.338 -0.871 -32.217 1.00 39.37 C \\\\nATOM 1652 ND2 ASN A 206 -59.478 -0.807 -31.571 1.00 39.37 N \\\\nATOM 1653 OD1 ASN A 206 -57.317 -0.484 -31.679 1.00 39.37 O \\\\nATOM 1654 N LEU A 207 -56.196 -3.312 -35.564 1.00 44.78 N \\\\nATOM 1655 CA LEU A 207 -56.487 -4.720 -35.904 1.00 44.78 C \\\\nATOM 1656 C LEU A 207 -55.433 -5.648 -35.248 1.00 44.78 C \\\\nATOM 1657 CB LEU A 207 -56.518 -4.928 -37.441 1.00 44.78 C \\\\nATOM 1658 O LEU A 207 -54.266 -5.622 -35.625 1.00 44.78 O \\\\nATOM 1659 CG LEU A 207 -57.917 -4.971 -38.099 1.00 44.78 C \\\\nATOM 1660 CD1 LEU A 207 -57.771 -4.972 -39.620 1.00 44.78 C \\\\nATOM 1661 CD2 LEU A 207 -58.716 -6.216 -37.699 1.00 44.78 C \\\\nATOM 1662 N SER A 208 -55.842 -6.478 -34.284 1.00 40.73 N \\\\nATOM 1663 CA SER A 208 -55.055 -7.621 -33.762 1.00 40.73 C \\\\nATOM 1664 C SER A 208 -55.432 -8.888 -34.557 1.00 40.73 C \\\\nATOM 1665 CB SER A 208 -55.324 -7.826 -32.261 1.00 40.73 C \\\\nATOM 1666 O SER A 208 -56.579 -8.945 -35.011 1.00 40.73 O \\\\nATOM 1667 OG SER A 208 -55.350 -6.605 -31.544 1.00 40.73 O \\\\nATOM 1668 N PRO A 209 -54.570 -9.926 -34.702 1.00 44.83 N \\\\nATOM 1669 CA PRO A 209 -54.400 -10.888 -33.596 1.00 44.83 C \\\\nATOM 1670 C PRO A 209 -53.067 -11.690 -33.521 1.00 44.83 C \\\\nATOM 1671 CB PRO A 209 -55.548 -11.872 -33.862 1.00 44.83 C \\\\nATOM 1672 O PRO A 209 -52.260 -11.716 -34.441 1.00 44.83 O \\\\nATOM 1673 CG PRO A 209 -55.517 -12.030 -35.384 1.00 44.83 C \\\\nATOM 1674 CD PRO A 209 -54.779 -10.779 -35.876 1.00 44.83 C \\\\nATOM 1675 N ASN A 210 -52.975 -12.466 -32.431 1.00 41.10 N \\\\nATOM 1676 CA ASN A 210 -52.140 -13.654 -32.163 1.00 41.10 C \\\\nATOM 1677 C ASN A 210 -50.635 -13.492 -31.825 1.00 41.10 C \\\\nATOM 1678 CB ASN A 210 -52.397 -14.760 -33.202 1.00 41.10 C \\\\nATOM 1679 O ASN A 210 -49.853 -13.017 -32.644 1.00 41.10 O \\\\nATOM 1680 CG ASN A 210 -53.775 -15.385 -33.076 1.00 41.10 C \\\\nATOM 1681 ND2 ASN A 210 -54.098 -16.329 -33.926 1.00 41.10 N \\\\nATOM 1682 OD1 ASN A 210 -54.574 -15.061 -32.210 1.00 41.10 O \\\\nATOM 1683 N PRO A 211 -50.195 -13.989 -30.644 1.00 40.72 N \\\\nATOM 1684 CA PRO A 211 -48.784 -14.075 -30.279 1.00 40.72 C \\\\nATOM 1685 C PRO A 211 -48.138 -15.368 -30.802 1.00 40.72 C \\\\nATOM 1686 CB PRO A 211 -48.777 -14.031 -28.748 1.00 40.72 C \\\\nATOM 1687 O PRO A 211 -48.693 -16.457 -30.648 1.00 40.72 O \\\\nATOM 1688 CG PRO A 211 -50.056 -14.780 -28.371 1.00 40.72 C \\\\nATOM 1689 CD PRO A 211 -51.010 -14.460 -29.524 1.00 40.72 C \\\\nATOM 1690 N MET A 212 -46.921 -15.265 -31.338 1.00 42.15 N \\\\nATOM 1691 CA MET A 212 -46.016 -16.412 -31.467 1.00 42.15 C \\\\nATOM 1692 C MET A 212 -45.120 -16.483 -30.229 1.00 42.15 C \\\\nATOM 1693 CB MET A 212 -45.197 -16.341 -32.766 1.00 42.15 C \\\\nATOM 1694 O MET A 212 -44.534 -15.481 -29.822 1.00 42.15 O \\\\nATOM 1695 CG MET A 212 -46.095 -16.597 -33.984 1.00 42.15 C \\\\nATOM 1696 SD MET A 212 -45.256 -16.690 -35.591 1.00 42.15 S \\\\nATOM 1697 CE MET A 212 -44.234 -18.174 -35.381 1.00 42.15 C \\\\nATOM 1698 N SER A 213 -45.035 -17.666 -29.621 1.00 39.51 N \\\\nATOM 1699 CA SER A 213 -44.201 -17.926 -28.446 1.00 39.51 C \\\\nATOM 1700 C SER A 213 -42.723 -17.623 -28.732 1.00 39.51 C \\\\nATOM 1701 CB SER A 213 -44.315 -19.400 -28.044 1.00 39.51 C \\\\nATOM 1702 O SER A 213 -42.234 -18.034 -29.788 1.00 39.51 O \\\\nATOM 1703 OG SER A 213 -45.673 -19.802 -27.981 1.00 39.51 O \\\\nATOM 1704 N PRO A 214 -41.972 -16.991 -27.810 1.00 42.72 N \\\\nATOM 1705 CA PRO A 214 -40.527 -16.881 -27.955 1.00 42.72 C \\\\nATOM 1706 C PRO A 214 -39.909 -18.278 -27.898 1.00 42.72 C \\\\nATOM 1707 CB PRO A 214 -40.030 -16.000 -26.800 1.00 42.72 C \\\\nATOM 1708 O PRO A 214 -40.210 -19.057 -26.990 1.00 42.72 O \\\\nATOM 1709 CG PRO A 214 -41.299 -15.382 -26.214 1.00 42.72 C \\\\nATOM 1710 CD PRO A 214 -42.392 -16.393 -26.555 1.00 42.72 C \\\\nATOM 1711 N ALA A 215 -39.018 -18.593 -28.837 1.00 38.54 N \\\\nATOM 1712 CA ALA A 215 -38.164 -19.761 -28.699 1.00 38.54 C \\\\nATOM 1713 C ALA A 215 -37.263 -19.558 -27.471 1.00 38.54 C \\\\nATOM 1714 CB ALA A 215 -37.366 -19.964 -29.993 1.00 38.54 C \\\\nATOM 1715 O ALA A 215 -36.411 -18.668 -27.457 1.00 38.54 O \\\\nATOM 1716 N HIS A 216 -37.455 -20.375 -26.433 1.00 40.42 N \\\\nATOM 1717 CA HIS A 216 -36.520 -20.447 -25.316 1.00 40.42 C \\\\nATOM 1718 C HIS A 216 -35.209 -21.071 -25.806 1.00 40.42 C \\\\nATOM 1719 CB HIS A 216 -37.123 -21.222 -24.129 1.00 40.42 C \\\\nATOM 1720 O HIS A 216 -35.005 -22.281 -25.704 1.00 40.42 O \\\\nATOM 1721 CG HIS A 216 -37.967 -20.379 -23.206 1.00 40.42 C \\\\nATOM 1722 CD2 HIS A 216 -39.316 -20.482 -22.997 1.00 40.42 C \\\\nATOM 1723 ND1 HIS A 216 -37.497 -19.419 -22.338 1.00 40.42 N \\\\nATOM 1724 CE1 HIS A 216 -38.538 -18.952 -21.629 1.00 40.42 C \\\\nATOM 1725 NE2 HIS A 216 -39.670 -19.572 -21.994 1.00 40.42 N \\\\nATOM 1726 N ASN A 217 -34.301 -20.230 -26.305 1.00 45.94 N \\\\nATOM 1727 CA ASN A 217 -32.886 -20.566 -26.348 1.00 45.94 C \\\\nATOM 1728 C ASN A 217 -32.417 -20.746 -24.900 1.00 45.94 C \\\\nATOM 1729 CB ASN A 217 -32.085 -19.479 -27.098 1.00 45.94 C \\\\nATOM 1730 O ASN A 217 -32.070 -19.777 -24.224 1.00 45.94 O \\\\nATOM 1731 CG ASN A 217 -32.078 -19.656 -28.607 1.00 45.94 C \\\\nATOM 1732 ND2 ASN A 217 -31.390 -18.796 -29.321 1.00 45.94 N \\\\nATOM 1733 OD1 ASN A 217 -32.661 -20.566 -29.167 1.00 45.94 O \\\\nATOM 1734 N ASN A 218 -32.422 -21.996 -24.430 1.00 48.29 N \\\\nATOM 1735 CA ASN A 218 -31.732 -22.420 -23.215 1.00 48.29 C \\\\nATOM 1736 C ASN A 218 -30.218 -22.322 -23.454 1.00 48.29 C \\\\nATOM 1737 CB ASN A 218 -32.196 -23.836 -22.795 1.00 48.29 C \\\\nATOM 1738 O ASN A 218 -29.524 -23.321 -23.636 1.00 48.29 O \\\\nATOM 1739 CG ASN A 218 -33.261 -23.865 -21.712 1.00 48.29 C \\\\nATOM 1740 ND2 ASN A 218 -33.691 -25.044 -21.328 1.00 48.29 N \\\\nATOM 1741 OD1 ASN A 218 -33.708 -22.868 -21.174 1.00 48.29 O \\\\nATOM 1742 N LEU A 219 -29.712 -21.090 -23.470 1.00 60.32 N \\\\nATOM 1743 CA LEU A 219 -28.303 -20.815 -23.246 1.00 60.32 C \\\\nATOM 1744 C LEU A 219 -27.998 -21.275 -21.819 1.00 60.32 C \\\\nATOM 1745 CB LEU A 219 -28.035 -19.313 -23.455 1.00 60.32 C \\\\nATOM 1746 O LEU A 219 -28.474 -20.677 -20.854 1.00 60.32 O \\\\nATOM 1747 CG LEU A 219 -28.042 -18.894 -24.937 1.00 60.32 C \\\\nATOM 1748 CD1 LEU A 219 -28.221 -17.382 -25.062 1.00 60.32 C \\\\nATOM 1749 CD2 LEU A 219 -26.732 -19.278 -25.630 1.00 60.32 C \\\\nATOM 1750 N ASP A 220 -27.247 -22.368 -21.699 1.00 74.45 N \\\\nATOM 1751 CA ASP A 220 -26.793 -22.909 -20.419 1.00 74.45 C \\\\nATOM 1752 C ASP A 220 -25.707 -21.976 -19.855 1.00 74.45 C \\\\nATOM 1753 CB ASP A 220 -26.366 -24.375 -20.612 1.00 74.45 C \\\\nATOM 1754 O ASP A 220 -24.509 -22.128 -20.106 1.00 74.45 O \\\\nATOM 1755 CG ASP A 220 -26.139 -25.137 -19.300 1.00 74.45 C \\\\nATOM 1756 OD1 ASP A 220 -26.610 -24.684 -18.235 1.00 74.45 O \\\\nATOM 1757 OD2 ASP A 220 -25.480 -26.202 -19.357 1.00 74.45 O \\\\nATOM 1758 N LEU A 221 -26.177 -20.912 -19.198 1.00 81.69 N \\\\nATOM 1759 CA LEU A 221 -25.384 -19.817 -18.652 1.00 81.69 C \\\\nATOM 1760 C LEU A 221 -24.868 -20.190 -17.261 1.00 81.69 C \\\\nATOM 1761 CB LEU A 221 -26.244 -18.539 -18.591 1.00 81.69 C \\\\nATOM 1762 O LEU A 221 -25.641 -20.307 -16.308 1.00 81.69 O \\\\nATOM 1763 CG LEU A 221 -26.532 -17.876 -19.951 1.00 81.69 C \\\\nATOM 1764 CD1 LEU A 221 -27.616 -16.809 -19.796 1.00 81.69 C \\\\nATOM 1765 CD2 LEU A 221 -25.300 -17.189 -20.537 1.00 81.69 C \\\\nATOM 1766 N GLN A 222 -23.551 -20.314 -17.121 1.00 85.05 N \\\\nATOM 1767 CA GLN A 222 -22.922 -20.623 -15.844 1.00 85.05 C \\\\nATOM 1768 C GLN A 222 -22.578 -19.327 -15.078 1.00 85.05 C \\\\nATOM 1769 CB GLN A 222 -21.723 -21.549 -16.088 1.00 85.05 C \\\\nATOM 1770 O GLN A 222 -21.875 -18.469 -15.616 1.00 85.05 O \\\\nATOM 1771 CG GLN A 222 -21.146 -22.068 -14.764 1.00 85.05 C \\\\nATOM 1772 CD GLN A 222 -20.201 -23.256 -14.935 1.00 85.05 C \\\\nATOM 1773 NE2 GLN A 222 -19.224 -23.405 -14.071 1.00 85.05 N \\\\nATOM 1774 OE1 GLN A 222 -20.361 -24.133 -15.776 1.00 85.05 O \\\\nATOM 1775 N PRO A 223 -23.056 -19.142 -13.830 1.00 90.37 N \\\\nATOM 1776 CA PRO A 223 -22.756 -17.950 -13.042 1.00 90.37 C \\\\nATOM 1777 C PRO A 223 -21.366 -18.020 -12.394 1.00 90.37 C \\\\nATOM 1778 CB PRO A 223 -23.877 -17.858 -12.003 1.00 90.37 C \\\\nATOM 1779 O PRO A 223 -21.036 -18.970 -11.681 1.00 90.37 O \\\\nATOM 1780 CG PRO A 223 -24.265 -19.319 -11.776 1.00 90.37 C \\\\nATOM 1781 CD PRO A 223 -24.053 -19.958 -13.149 1.00 90.37 C \\\\nATOM 1782 N VAL A 224 -20.577 -16.961 -12.571 1.00 90.45 N \\\\nATOM 1783 CA VAL A 224 -19.236 -16.791 -12.000 1.00 90.45 C \\\\nATOM 1784 C VAL A 224 -19.241 -15.674 -10.963 1.00 90.45 C \\\\nATOM 1785 CB VAL A 224 -18.185 -16.520 -13.094 1.00 90.45 C \\\\nATOM 1786 O VAL A 224 -19.332 -14.489 -11.293 1.00 90.45 O \\\\nATOM 1787 CG1 VAL A 224 -16.787 -16.560 -12.468 1.00 90.45 C \\\\nATOM 1788 CG2 VAL A 224 -18.242 -17.587 -14.185 1.00 90.45 C \\\\nATOM 1789 N THR A 225 -19.119 -16.047 -9.690 1.00 90.96 N \\\\nATOM 1790 CA THR A 225 -19.107 -15.113 -8.558 1.00 90.96 C \\\\nATOM 1791 C THR A 225 -17.708 -14.574 -8.245 1.00 90.96 C \\\\nATOM 1792 CB THR A 225 -19.718 -15.750 -7.299 1.00 90.96 C \\\\nATOM 1793 O THR A 225 -16.707 -15.306 -8.235 1.00 90.96 O \\\\nATOM 1794 CG2 THR A 225 -21.223 -15.974 -7.443 1.00 90.96 C \\\\nATOM 1795 OG1 THR A 225 -19.143 -17.012 -7.043 1.00 90.96 O \\\\nATOM 1796 N TYR A 226 -17.656 -13.279 -7.920 1.00 91.36 N \\\\nATOM 1797 CA TYR A 226 -16.485 -12.645 -7.317 1.00 91.36 C \\\\nATOM 1798 C TYR A 226 -16.177 -13.268 -5.947 1.00 91.36 C \\\\nATOM 1799 CB TYR A 226 -16.729 -11.137 -7.179 1.00 91.36 C \\\\nATOM 1800 O TYR A 226 -17.081 -13.659 -5.205 1.00 91.36 O \\\\nATOM 1801 CG TYR A 226 -15.526 -10.357 -6.675 1.00 91.36 C \\\\nATOM 1802 CD1 TYR A 226 -15.400 -10.011 -5.314 1.00 91.36 C \\\\nATOM 1803 CD2 TYR A 226 -14.536 -9.953 -7.586 1.00 91.36 C \\\\nATOM 1804 CE1 TYR A 226 -14.290 -9.258 -4.874 1.00 91.36 C \\\\nATOM 1805 CE2 TYR A 226 -13.447 -9.174 -7.158 1.00 91.36 C \\\\nATOM 1806 OH TYR A 226 -12.242 -8.086 -5.408 1.00 91.36 O \\\\nATOM 1807 CZ TYR A 226 -13.310 -8.831 -5.798 1.00 91.36 C \\\\nATOM 1808 N CYS A 227 -14.896 -13.343 -5.592 1.00 88.04 N \\\\nATOM 1809 CA CYS A 227 -14.446 -13.685 -4.245 1.00 88.04 C \\\\nATOM 1810 C CYS A 227 -13.320 -12.729 -3.857 1.00 88.04 C \\\\nATOM 1811 CB CYS A 227 -13.971 -15.144 -4.176 1.00 88.04 C \\\\nATOM 1812 O CYS A 227 -12.443 -12.461 -4.673 1.00 88.04 O \\\\nATOM 1813 SG CYS A 227 -15.324 -16.288 -4.590 1.00 88.04 S \\\\nATOM 1814 N GLU A 228 -13.341 -12.228 -2.624 1.00 87.08 N \\\\nATOM 1815 CA GLU A 228 -12.293 -11.333 -2.136 1.00 87.08 C \\\\nATOM 1816 C GLU A 228 -11.044 -12.157 -1.749 1.00 87.08 C \\\\nATOM 1817 CB GLU A 228 -12.835 -10.504 -0.959 1.00 87.08 C \\\\nATOM 1818 O GLU A 228 -11.162 -13.089 -0.945 1.00 87.08 O \\\\nATOM 1819 CG GLU A 228 -12.081 -9.184 -0.760 1.00 87.08 C \\\\nATOM 1820 CD GLU A 228 -12.445 -8.166 -1.847 1.00 87.08 C \\\\nATOM 1821 OE1 GLU A 228 -11.724 -8.084 -2.862 1.00 87.08 O \\\\nATOM 1822 OE2 GLU A 228 -13.462 -7.454 -1.705 1.00 87.08 O \\\\nATOM 1823 N PRO A 229 -9.856 -11.871 -2.307 1.00 91.38 N \\\\nATOM 1824 CA PRO A 229 -8.630 -12.602 -1.993 1.00 91.38 C \\\\nATOM 1825 C PRO A 229 -8.013 -12.151 -0.659 1.00 91.38 C \\\\nATOM 1826 CB PRO A 229 -7.696 -12.322 -3.172 1.00 91.38 C \\\\nATOM 1827 O PRO A 229 -8.198 -11.022 -0.213 1.00 91.38 O \\\\nATOM 1828 CG PRO A 229 -8.092 -10.899 -3.553 1.00 91.38 C \\\\nATOM 1829 CD PRO A 229 -9.602 -10.891 -3.353 1.00 91.38 C \\\\nATOM 1830 N ALA A 230 -7.183 -13.009 -0.054 1.00 90.34 N \\\\nATOM 1831 CA ALA A 230 -6.465 -12.698 1.192 1.00 90.34 C \\\\nATOM 1832 C ALA A 230 -5.456 -11.533 1.066 1.00 90.34 C \\\\nATOM 1833 CB ALA A 230 -5.759 -13.977 1.660 1.00 90.34 C \\\\nATOM 1834 O ALA A 230 -5.130 -10.879 2.056 1.00 90.34 O \\\\nATOM 1835 N PHE A 231 -4.973 -11.272 -0.152 1.00 94.61 N \\\\nATOM 1836 CA PHE A 231 -4.199 -10.086 -0.509 1.00 94.61 C \\\\nATOM 1837 C PHE A 231 -4.930 -9.383 -1.649 1.00 94.61 C \\\\nATOM 1838 CB PHE A 231 -2.775 -10.474 -0.935 1.00 94.61 C \\\\nATOM 1839 O PHE A 231 -5.084 -9.979 -2.715 1.00 94.61 O \\\\nATOM 1840 CG PHE A 231 -1.985 -11.239 0.107 1.00 94.61 C \\\\nATOM 1841 CD1 PHE A 231 -1.300 -10.545 1.119 1.00 94.61 C \\\\nATOM 1842 CD2 PHE A 231 -1.917 -12.644 0.056 1.00 94.61 C \\\\nATOM 1843 CE1 PHE A 231 -0.547 -11.247 2.076 1.00 94.61 C \\\\nATOM 1844 CE2 PHE A 231 -1.170 -13.349 1.017 1.00 94.61 C \\\\nATOM 1845 CZ PHE A 231 -0.486 -12.650 2.027 1.00 94.61 C \\\\nATOM 1846 N TRP A 232 -5.376 -8.142 -1.456 1.00 95.43 N \\\\nATOM 1847 CA TRP A 232 -6.197 -7.431 -2.445 1.00 95.43 C \\\\nATOM 1848 C TRP A 232 -5.375 -6.933 -3.644 1.00 95.43 C \\\\nATOM 1849 CB TRP A 232 -6.971 -6.306 -1.752 1.00 95.43 C \\\\nATOM 1850 O TRP A 232 -5.883 -6.886 -4.766 1.00 95.43 O \\\\nATOM 1851 CG TRP A 232 -6.131 -5.200 -1.196 1.00 95.43 C \\\\nATOM 1852 CD1 TRP A 232 -5.652 -5.120 0.065 1.00 95.43 C \\\\nATOM 1853 CD2 TRP A 232 -5.664 -3.998 -1.878 1.00 95.43 C \\\\nATOM 1854 CE2 TRP A 232 -4.882 -3.233 -0.963 1.00 95.43 C \\\\nATOM 1855 CE3 TRP A 232 -5.831 -3.479 -3.180 1.00 95.43 C \\\\nATOM 1856 NE1 TRP A 232 -4.917 -3.961 0.205 1.00 95.43 N \\\\nATOM 1857 CH2 TRP A 232 -4.469 -1.529 -2.630 1.00 95.43 C \\\\nATOM 1858 CZ2 TRP A 232 -4.287 -2.015 -1.323 1.00 95.43 C \\\\nATOM 1859 CZ3 TRP A 232 -5.238 -2.259 -3.554 1.00 95.43 C \\\\nATOM 1860 N CYS A 233 -4.085 -6.643 -3.443 1.00 97.66 N \\\\nATOM 1861 CA CYS A 233 -3.142 -6.409 -4.533 1.00 97.66 C \\\\nATOM 1862 C CYS A 233 -1.744 -6.980 -4.268 1.00 97.66 C \\\\nATOM 1863 CB CYS A 233 -3.097 -4.915 -4.904 1.00 97.66 C \\\\nATOM 1864 O CYS A 233 -1.371 -7.311 -3.137 1.00 97.66 O \\\\nATOM 1865 SG CYS A 233 -2.220 -3.908 -3.672 1.00 97.66 S \\\\nATOM 1866 N SER A 234 -0.963 -7.073 -5.340 1.00 98.00 N \\\\nATOM 1867 CA SER A 234 0.484 -7.274 -5.297 1.00 98.00 C \\\\nATOM 1868 C SER A 234 1.196 -6.126 -6.021 1.00 98.00 C \\\\nATOM 1869 CB SER A 234 0.855 -8.653 -5.846 1.00 98.00 C \\\\nATOM 1870 O SER A 234 0.656 -5.569 -6.978 1.00 98.00 O \\\\nATOM 1871 OG SER A 234 0.561 -8.773 -7.220 1.00 98.00 O \\\\nATOM 1872 N ILE A 235 2.374 -5.727 -5.534 1.00 98.48 N \\\\nATOM 1873 CA ILE A 235 3.124 -4.561 -6.018 1.00 98.48 C \\\\nATOM 1874 C ILE A 235 4.563 -4.957 -6.337 1.00 98.48 C \\\\nATOM 1875 CB ILE A 235 3.083 -3.380 -5.017 1.00 98.48 C \\\\nATOM 1876 O ILE A 235 5.286 -5.443 -5.467 1.00 98.48 O \\\\nATOM 1877 CG1 ILE A 235 1.628 -3.071 -4.597 1.00 98.48 C \\\\nATOM 1878 CG2 ILE A 235 3.764 -2.146 -5.646 1.00 98.48 C \\\\nATOM 1879 CD1 ILE A 235 1.453 -1.811 -3.745 1.00 98.48 C \\\\nATOM 1880 N SER A 236 5.002 -4.695 -7.566 1.00 98.56 N \\\\nATOM 1881 CA SER A 236 6.394 -4.879 -7.998 1.00 98.56 C \\\\nATOM 1882 C SER A 236 7.045 -3.523 -8.282 1.00 98.56 C \\\\nATOM 1883 CB SER A 236 6.453 -5.806 -9.215 1.00 98.56 C \\\\nATOM 1884 O SER A 236 6.434 -2.671 -8.924 1.00 98.56 O \\\\nATOM 1885 OG SER A 236 5.926 -7.081 -8.879 1.00 98.56 O \\\\nATOM 1886 N TYR A 237 8.271 -3.307 -7.796 1.00 98.69 N \\\\nATOM 1887 CA TYR A 237 9.032 -2.067 -7.999 1.00 98.69 C \\\\nATOM 1888 C TYR A 237 10.047 -2.195 -9.137 1.00 98.69 C \\\\nATOM 1889 CB TYR A 237 9.692 -1.633 -6.680 1.00 98.69 C \\\\nATOM 1890 O TYR A 237 10.666 -3.245 -9.328 1.00 98.69 O \\\\nATOM 1891 CG TYR A 237 10.637 -0.444 -6.789 1.00 98.69 C \\\\nATOM 1892 CD1 TYR A 237 12.003 -0.597 -6.486 1.00 98.69 C \\\\nATOM 1893 CD2 TYR A 237 10.156 0.816 -7.191 1.00 98.69 C \\\\nATOM 1894 CE1 TYR A 237 12.878 0.503 -6.562 1.00 98.69 C \\\\nATOM 1895 CE2 TYR A 237 11.029 1.915 -7.294 1.00 98.69 C \\\\nATOM 1896 OH TYR A 237 13.219 2.844 -6.988 1.00 98.69 O \\\\nATOM 1897 CZ TYR A 237 12.391 1.765 -6.962 1.00 98.69 C \\\\nATOM 1898 N TYR A 238 10.217 -1.103 -9.881 1.00 98.77 N \\\\nATOM 1899 CA TYR A 238 11.071 -1.011 -11.053 1.00 98.77 C \\\\nATOM 1900 C TYR A 238 11.893 0.282 -11.053 1.00 98.77 C \\\\nATOM 1901 CB TYR A 238 10.215 -1.095 -12.322 1.00 98.77 C \\\\nATOM 1902 O TYR A 238 11.424 1.369 -10.693 1.00 98.77 O \\\\nATOM 1903 CG TYR A 238 9.557 -2.438 -12.582 1.00 98.77 C \\\\nATOM 1904 CD1 TYR A 238 10.127 -3.335 -13.507 1.00 98.77 C \\\\nATOM 1905 CD2 TYR A 238 8.351 -2.771 -11.935 1.00 98.77 C \\\\nATOM 1906 CE1 TYR A 238 9.513 -4.577 -13.760 1.00 98.77 C \\\\nATOM 1907 CE2 TYR A 238 7.751 -4.023 -12.163 1.00 98.77 C \\\\nATOM 1908 OH TYR A 238 7.774 -6.155 -13.249 1.00 98.77 O \\\\nATOM 1909 CZ TYR A 238 8.338 -4.934 -13.063 1.00 98.77 C \\\\nATOM 1910 N GLU A 239 13.128 0.159 -11.527 1.00 98.62 N \\\\nATOM 1911 CA GLU A 239 14.019 1.264 -11.862 1.00 98.62 C \\\\nATOM 1912 C GLU A 239 14.323 1.165 -13.362 1.00 98.62 C \\\\nATOM 1913 CB GLU A 239 15.284 1.228 -10.979 1.00 98.62 C \\\\nATOM 1914 O GLU A 239 14.958 0.211 -13.810 1.00 98.62 O \\\\nATOM 1915 CG GLU A 239 14.940 1.495 -9.500 1.00 98.62 C \\\\nATOM 1916 CD GLU A 239 16.132 1.483 -8.527 1.00 98.62 C \\\\nATOM 1917 OE1 GLU A 239 15.922 1.704 -7.311 1.00 98.62 O \\\\nATOM 1918 OE2 GLU A 239 17.306 1.282 -8.916 1.00 98.62 O \\\\nATOM 1919 N LEU A 240 13.834 2.127 -14.153 1.00 98.06 N \\\\nATOM 1920 CA LEU A 240 13.823 2.051 -15.621 1.00 98.06 C \\\\nATOM 1921 C LEU A 240 13.079 0.792 -16.117 1.00 98.06 C \\\\nATOM 1922 CB LEU A 240 15.248 2.233 -16.192 1.00 98.06 C \\\\nATOM 1923 O LEU A 240 11.916 0.600 -15.776 1.00 98.06 O \\\\nATOM 1924 CG LEU A 240 15.969 3.510 -15.728 1.00 98.06 C \\\\nATOM 1925 CD1 LEU A 240 17.434 3.448 -16.154 1.00 98.06 C \\\\nATOM 1926 CD2 LEU A 240 15.350 4.776 -16.327 1.00 98.06 C \\\\nATOM 1927 N ASN A 241 13.710 -0.073 -16.912 1.00 97.14 N \\\\nATOM 1928 CA ASN A 241 13.154 -1.360 -17.346 1.00 97.14 C \\\\nATOM 1929 C ASN A 241 13.502 -2.533 -16.405 1.00 97.14 C \\\\nATOM 1930 CB ASN A 241 13.596 -1.633 -18.797 1.00 97.14 C \\\\nATOM 1931 O ASN A 241 13.069 -3.658 -16.655 1.00 97.14 O \\\\nATOM 1932 CG ASN A 241 15.097 -1.813 -18.965 1.00 97.14 C \\\\nATOM 1933 ND2 ASN A 241 15.528 -2.374 -20.069 1.00 97.14 N \\\\nATOM 1934 OD1 ASN A 241 15.903 -1.420 -18.136 1.00 97.14 O \\\\nATOM 1935 N GLN A 242 14.276 -2.305 -15.340 1.00 97.90 N \\\\nATOM 1936 CA GLN A 242 14.739 -3.357 -14.439 1.00 97.90 C \\\\nATOM 1937 C GLN A 242 13.834 -3.473 -13.211 1.00 97.90 C \\\\nATOM 1938 CB GLN A 242 16.203 -3.092 -14.058 1.00 97.90 C \\\\nATOM 1939 O GLN A 242 13.608 -2.500 -12.494 1.00 97.90 O \\\\nATOM 1940 CG GLN A 242 16.783 -4.233 -13.207 1.00 97.90 C \\\\nATOM 1941 CD GLN A 242 18.248 -4.032 -12.846 1.00 97.90 C \\\\nATOM 1942 NE2 GLN A 242 18.831 -4.925 -12.081 1.00 97.90 N \\\\nATOM 1943 OE1 GLN A 242 18.908 -3.084 -13.238 1.00 97.90 O \\\\nATOM 1944 N ARG A 243 13.365 -4.690 -12.920 1.00 98.06 N \\\\nATOM 1945 CA ARG A 243 12.677 -5.004 -11.663 1.00 98.06 C \\\\nATOM 1946 C ARG A 243 13.668 -4.998 -10.495 1.00 98.06 C \\\\nATOM 1947 CB ARG A 243 11.953 -6.346 -11.809 1.00 98.06 C \\\\nATOM 1948 O ARG A 243 14.748 -5.576 -10.598 1.00 98.06 O \\\\nATOM 1949 CG ARG A 243 11.106 -6.643 -10.571 1.00 98.06 C \\\\nATOM 1950 CD ARG A 243 10.301 -7.925 -10.764 1.00 98.06 C \\\\nATOM 1951 NE ARG A 243 9.956 -8.477 -9.451 1.00 98.06 N \\\\nATOM 1952 NH1 ARG A 243 8.193 -9.836 -10.058 1.00 98.06 N \\\\nATOM 1953 NH2 ARG A 243 8.897 -9.730 -7.940 1.00 98.06 N \\\\nATOM 1954 CZ ARG A 243 9.014 -9.349 -9.171 1.00 98.06 C \\\\nATOM 1955 N VAL A 244 13.291 -4.378 -9.379 1.00 98.38 N \\\\nATOM 1956 CA VAL A 244 14.143 -4.200 -8.196 1.00 98.38 C \\\\nATOM 1957 C VAL A 244 13.391 -4.645 -6.941 1.00 98.38 C \\\\nATOM 1958 CB VAL A 244 14.626 -2.736 -8.101 1.00 98.38 C \\\\nATOM 1959 O VAL A 244 12.381 -4.055 -6.570 1.00 98.38 O \\\\nATOM 1960 CG1 VAL A 244 15.439 -2.476 -6.827 1.00 98.38 C \\\\nATOM 1961 CG2 VAL A 244 15.519 -2.366 -9.293 1.00 98.38 C \\\\nATOM 1962 N GLY A 245 13.918 -5.665 -6.260 1.00 96.94 N \\\\nATOM 1963 CA GLY A 245 13.327 -6.223 -5.041 1.00 96.94 C \\\\nATOM 1964 C GLY A 245 12.210 -7.251 -5.269 1.00 96.94 C \\\\nATOM 1965 O GLY A 245 11.853 -7.617 -6.394 1.00 96.94 O \\\\nATOM 1966 N GLU A 246 11.680 -7.746 -4.153 1.00 96.05 N \\\\nATOM 1967 CA GLU A 246 10.594 -8.728 -4.106 1.00 96.05 C \\\\nATOM 1968 C GLU A 246 9.227 -8.084 -4.399 1.00 96.05 C \\\\nATOM 1969 CB GLU A 246 10.600 -9.438 -2.742 1.00 96.05 C \\\\nATOM 1970 O GLU A 246 9.067 -6.864 -4.327 1.00 96.05 O \\\\nATOM 1971 CG GLU A 246 11.927 -10.178 -2.493 1.00 96.05 C \\\\nATOM 1972 CD GLU A 246 11.932 -10.976 -1.182 1.00 96.05 C \\\\nATOM 1973 OE1 GLU A 246 12.596 -12.035 -1.169 1.00 96.05 O \\\\nATOM 1974 OE2 GLU A 246 11.300 -10.506 -0.211 1.00 96.05 O \\\\nATOM 1975 N THR A 247 8.223 -8.900 -4.741 1.00 97.28 N \\\\nATOM 1976 CA THR A 247 6.836 -8.416 -4.842 1.00 97.28 C \\\\nATOM 1977 C THR A 247 6.261 -8.242 -3.439 1.00 97.28 C \\\\nATOM 1978 CB THR A 247 5.942 -9.364 -5.659 1.00 97.28 C \\\\nATOM 1979 O THR A 247 6.203 -9.197 -2.663 1.00 97.28 O \\\\nATOM 1980 CG2 THR A 247 4.483 -8.934 -5.724 1.00 97.28 C \\\\nATOM 1981 OG1 THR A 247 6.361 -9.404 -7.003 1.00 97.28 O \\\\nATOM 1982 N PHE A 248 5.779 -7.043 -3.130 1.00 97.00 N \\\\nATOM 1983 CA PHE A 248 5.022 -6.783 -1.912 1.00 97.00 C \\\\nATOM 1984 C PHE A 248 3.574 -7.265 -2.077 1.00 97.00 C \\\\nATOM 1985 CB PHE A 248 5.102 -5.290 -1.588 1.00 97.00 C \\\\nATOM 1986 O PHE A 248 2.968 -7.046 -3.124 1.00 97.00 O \\\\nATOM 1987 CG PHE A 248 4.498 -4.937 -0.248 1.00 97.00 C \\\\nATOM 1988 CD1 PHE A 248 3.108 -4.751 -0.124 1.00 97.00 C \\\\nATOM 1989 CD2 PHE A 248 5.327 -4.822 0.884 1.00 97.00 C \\\\nATOM 1990 CE1 PHE A 248 2.550 -4.462 1.132 1.00 97.00 C \\\\nATOM 1991 CE2 PHE A 248 4.771 -4.501 2.134 1.00 97.00 C \\\\nATOM 1992 CZ PHE A 248 3.383 -4.322 2.254 1.00 97.00 C \\\\nATOM 1993 N HIS A 249 2.996 -7.886 -1.048 1.00 97.02 N \\\\nATOM 1994 CA HIS A 249 1.628 -8.415 -1.075 1.00 97.02 C \\\\nATOM 1995 C HIS A 249 0.777 -7.718 -0.006 1.00 97.02 C \\\\nATOM 1996 CB HIS A 249 1.668 -9.938 -0.893 1.00 97.02 C \\\\nATOM 1997 O HIS A 249 1.065 -7.816 1.186 1.00 97.02 O \\\\nATOM 1998 CG HIS A 249 2.379 -10.664 -2.010 1.00 97.02 C \\\\nATOM 1999 CD2 HIS A 249 1.784 -11.303 -3.065 1.00 97.02 C \\\\nATOM 2000 ND1 HIS A 249 3.740 -10.819 -2.165 1.00 97.02 N \\\\nATOM 2001 CE1 HIS A 249 3.954 -11.537 -3.277 1.00 97.02 C \\\\nATOM 2002 NE2 HIS A 249 2.791 -11.844 -3.870 1.00 97.02 N \\\\nATOM 2003 N ALA A 250 -0.265 -6.997 -0.425 1.00 95.01 N \\\\nATOM 2004 CA ALA A 250 -1.051 -6.142 0.459 1.00 95.01 C \\\\nATOM 2005 C ALA A 250 -2.266 -6.885 1.031 1.00 95.01 C \\\\nATOM 2006 CB ALA A 250 -1.460 -4.890 -0.323 1.00 95.01 C \\\\nATOM 2007 O ALA A 250 -3.233 -7.147 0.317 1.00 95.01 O \\\\nATOM 2008 N SER A 251 -2.227 -7.219 2.324 1.00 91.07 N \\\\nATOM 2009 CA SER A 251 -3.373 -7.794 3.047 1.00 91.07 C \\\\nATOM 2010 C SER A 251 -4.229 -6.731 3.737 1.00 91.07 C \\\\nATOM 2011 CB SER A 251 -2.896 -8.827 4.069 1.00 91.07 C \\\\nATOM 2012 O SER A 251 -5.447 -6.868 3.805 1.00 91.07 O \\\\nATOM 2013 OG SER A 251 -1.964 -8.254 4.975 1.00 91.07 O \\\\nATOM 2014 N GLN A 252 -3.615 -5.649 4.226 1.00 90.73 N \\\\nATOM 2015 CA GLN A 252 -4.331 -4.580 4.924 1.00 90.73 C \\\\nATOM 2016 C GLN A 252 -5.089 -3.667 3.945 1.00 90.73 C \\\\nATOM 2017 CB GLN A 252 -3.369 -3.767 5.810 1.00 90.73 C \\\\nATOM 2018 O GLN A 252 -4.523 -3.317 2.904 1.00 90.73 O \\\\nATOM 2019 CG GLN A 252 -2.758 -4.604 6.947 1.00 90.73 C \\\\nATOM 2020 CD GLN A 252 -3.801 -5.213 7.884 1.00 90.73 C \\\\nATOM 2021 NE2 GLN A 252 -3.472 -6.274 8.586 1.00 90.73 N \\\\nATOM 2022 OE1 GLN A 252 -4.936 -4.780 7.987 1.00 90.73 O \\\\nATOM 2023 N PRO A 253 -6.313 -3.194 4.272 1.00 90.20 N \\\\nATOM 2024 CA PRO A 253 -7.105 -2.315 3.397 1.00 90.20 C \\\\nATOM 2025 C PRO A 253 -6.448 -0.966 3.070 1.00 90.20 C \\\\nATOM 2026 CB PRO A 253 -8.428 -2.075 4.136 1.00 90.20 C \\\\nATOM 2027 O PRO A 253 -6.895 -0.256 2.175 1.00 90.20 O \\\\nATOM 2028 CG PRO A 253 -8.556 -3.278 5.064 1.00 90.20 C \\\\nATOM 2029 CD PRO A 253 -7.107 -3.576 5.437 1.00 90.20 C \\\\nATOM 2030 N SER A 254 -5.403 -0.580 3.802 1.00 93.37 N \\\\nATOM 2031 CA SER A 254 -4.603 0.618 3.560 1.00 93.37 C \\\\nATOM 2032 C SER A 254 -3.127 0.267 3.695 1.00 93.37 C \\\\nATOM 2033 CB SER A 254 -5.004 1.713 4.557 1.00 93.37 C \\\\nATOM 2034 O SER A 254 -2.726 -0.324 4.692 1.00 93.37 O \\\\nATOM 2035 OG SER A 254 -4.131 2.832 4.511 1.00 93.37 O \\\\nATOM 2036 N MET A 255 -2.311 0.706 2.741 1.00 95.32 N \\\\nATOM 2037 CA MET A 255 -0.854 0.588 2.792 1.00 95.32 C \\\\nATOM 2038 C MET A 255 -0.169 1.840 2.233 1.00 95.32 C \\\\nATOM 2039 CB MET A 255 -0.395 -0.682 2.060 1.00 95.32 C \\\\nATOM 2040 O MET A 255 -0.796 2.671 1.576 1.00 95.32 O \\\\nATOM 2041 CG MET A 255 -0.550 -0.591 0.534 1.00 95.32 C \\\\nATOM 2042 SD MET A 255 0.361 -1.848 -0.389 1.00 95.32 S \\\\nATOM 2043 CE MET A 255 2.074 -1.433 0.046 1.00 95.32 C \\\\nATOM 2044 N THR A 256 1.135 1.974 2.461 1.00 97.98 N \\\\nATOM 2045 CA THR A 256 1.963 3.043 1.885 1.00 97.98 C \\\\nATOM 2046 C THR A 256 3.144 2.443 1.129 1.00 97.98 C \\\\nATOM 2047 CB THR A 256 2.449 4.016 2.971 1.00 97.98 C \\\\nATOM 2048 O THR A 256 3.807 1.546 1.639 1.00 97.98 O \\\\nATOM 2049 CG2 THR A 256 3.014 5.307 2.385 1.00 97.98 C \\\\nATOM 2050 OG1 THR A 256 1.371 4.392 3.804 1.00 97.98 O \\\\nATOM 2051 N VAL A 257 3.434 2.942 -0.070 1.00 98.59 N \\\\nATOM 2052 CA VAL A 257 4.696 2.681 -0.775 1.00 98.59 C \\\\nATOM 2053 C VAL A 257 5.546 3.939 -0.637 1.00 98.59 C \\\\nATOM 2054 CB VAL A 257 4.466 2.311 -2.252 1.00 98.59 C \\\\nATOM 2055 O VAL A 257 5.147 4.992 -1.136 1.00 98.59 O \\\\nATOM 2056 CG1 VAL A 257 5.791 1.898 -2.897 1.00 98.59 C \\\\nATOM 2057 CG2 VAL A 257 3.451 1.175 -2.436 1.00 98.59 C \\\\nATOM 2058 N ASP A 258 6.672 3.861 0.073 1.00 98.59 N \\\\nATOM 2059 CA ASP A 258 7.464 5.030 0.481 1.00 98.59 C \\\\nATOM 2060 C ASP A 258 8.975 4.871 0.236 1.00 98.59 C \\\\nATOM 2061 CB ASP A 258 7.095 5.455 1.918 1.00 98.59 C \\\\nATOM 2062 O ASP A 258 9.464 3.803 -0.117 1.00 98.59 O \\\\nATOM 2063 CG ASP A 258 7.618 4.573 3.055 1.00 98.59 C \\\\nATOM 2064 OD1 ASP A 258 8.842 4.336 3.109 1.00 98.59 O \\\\nATOM 2065 OD2 ASP A 258 6.856 4.304 4.015 1.00 98.59 O \\\\nATOM 2066 N GLY A 259 9.722 5.970 0.356 1.00 98.35 N \\\\nATOM 2067 CA GLY A 259 11.163 6.037 0.098 1.00 98.35 C \\\\nATOM 2068 C GLY A 259 12.046 5.753 1.317 1.00 98.35 C \\\\nATOM 2069 O GLY A 259 13.248 6.001 1.246 1.00 98.35 O \\\\nATOM 2070 N PHE A 260 11.484 5.287 2.436 1.00 97.98 N \\\\nATOM 2071 CA PHE A 260 12.225 5.007 3.667 1.00 97.98 C \\\\nATOM 2072 C PHE A 260 12.692 3.537 3.722 1.00 97.98 C \\\\nATOM 2073 CB PHE A 260 11.377 5.441 4.874 1.00 97.98 C \\\\nATOM 2074 O PHE A 260 12.752 2.855 2.700 1.00 97.98 O \\\\nATOM 2075 CG PHE A 260 10.859 6.873 4.828 1.00 97.98 C \\\\nATOM 2076 CD1 PHE A 260 11.765 7.951 4.833 1.00 97.98 C \\\\nATOM 2077 CD2 PHE A 260 9.476 7.137 4.793 1.00 97.98 C \\\\nATOM 2078 CE1 PHE A 260 11.293 9.276 4.802 1.00 97.98 C \\\\nATOM 2079 CE2 PHE A 260 9.002 8.460 4.769 1.00 97.98 C \\\\nATOM 2080 CZ PHE A 260 9.911 9.533 4.771 1.00 97.98 C \\\\nATOM 2081 N THR A 261 13.114 3.057 4.898 1.00 97.45 N \\\\nATOM 2082 CA THR A 261 13.944 1.843 5.042 1.00 97.45 C \\\\nATOM 2083 C THR A 261 13.457 0.865 6.124 1.00 97.45 C \\\\nATOM 2084 CB THR A 261 15.413 2.228 5.303 1.00 97.45 C \\\\nATOM 2085 O THR A 261 14.274 0.237 6.791 1.00 97.45 O \\\\nATOM 2086 CG2 THR A 261 16.016 3.142 4.236 1.00 97.45 C \\\\nATOM 2087 OG1 THR A 261 15.497 2.905 6.536 1.00 97.45 O \\\\nATOM 2088 N ASP A 262 12.148 0.768 6.359 1.00 95.17 N \\\\nATOM 2089 CA ASP A 262 11.557 -0.171 7.330 1.00 95.17 C \\\\nATOM 2090 C ASP A 262 11.226 -1.508 6.631 1.00 95.17 C \\\\nATOM 2091 CB ASP A 262 10.329 0.514 7.949 1.00 95.17 C \\\\nATOM 2092 O ASP A 262 10.349 -1.517 5.765 1.00 95.17 O \\\\nATOM 2093 CG ASP A 262 9.506 -0.309 8.941 1.00 95.17 C \\\\nATOM 2094 OD1 ASP A 262 9.875 -1.471 9.213 1.00 95.17 O \\\\nATOM 2095 OD2 ASP A 262 8.501 0.287 9.413 1.00 95.17 O \\\\nATOM 2096 N PRO A 263 11.930 -2.617 6.940 1.00 92.14 N \\\\nATOM 2097 CA PRO A 263 11.783 -3.882 6.221 1.00 92.14 C \\\\nATOM 2098 C PRO A 263 10.658 -4.780 6.757 1.00 92.14 C \\\\nATOM 2099 CB PRO A 263 13.144 -4.569 6.390 1.00 92.14 C \\\\nATOM 2100 O PRO A 263 10.397 -5.820 6.161 1.00 92.14 O \\\\nATOM 2101 CG PRO A 263 13.546 -4.156 7.805 1.00 92.14 C \\\\nATOM 2102 CD PRO A 263 13.025 -2.721 7.898 1.00 92.14 C \\\\nATOM 2103 N SER A 264 10.043 -4.456 7.901 1.00 89.29 N \\\\nATOM 2104 CA SER A 264 9.228 -5.412 8.675 1.00 89.29 C \\\\nATOM 2105 C SER A 264 7.748 -5.047 8.797 1.00 89.29 C \\\\nATOM 2106 CB SER A 264 9.852 -5.611 10.058 1.00 89.29 C \\\\nATOM 2107 O SER A 264 6.975 -5.786 9.409 1.00 89.29 O \\\\nATOM 2108 OG SER A 264 9.904 -4.393 10.775 1.00 89.29 O \\\\nATOM 2109 N ASN A 265 7.334 -3.917 8.228 1.00 88.56 N \\\\nATOM 2110 CA ASN A 265 5.992 -3.379 8.391 1.00 88.56 C \\\\nATOM 2111 C ASN A 265 5.062 -3.788 7.234 1.00 88.56 C \\\\nATOM 2112 CB ASN A 265 6.154 -1.869 8.581 1.00 88.56 C \\\\nATOM 2113 O ASN A 265 5.209 -3.325 6.106 1.00 88.56 O \\\\nATOM 2114 CG ASN A 265 4.866 -1.162 8.931 1.00 88.56 C \\\\nATOM 2115 ND2 ASN A 265 4.961 -0.102 9.695 1.00 88.56 N \\\\nATOM 2116 OD1 ASN A 265 3.773 -1.539 8.554 1.00 88.56 O \\\\nATOM 2117 N SER A 266 4.054 -4.613 7.527 1.00 89.15 N \\\\nATOM 2118 CA SER A 266 3.077 -5.123 6.550 1.00 89.15 C \\\\nATOM 2119 C SER A 266 2.102 -4.074 5.990 1.00 89.15 C \\\\nATOM 2120 CB SER A 266 2.299 -6.287 7.168 1.00 89.15 C \\\\nATOM 2121 O SER A 266 1.358 -4.377 5.060 1.00 89.15 O \\\\nATOM 2122 OG SER A 266 1.744 -5.908 8.415 1.00 89.15 O \\\\nATOM 2123 N GLU A 267 2.116 -2.839 6.498 1.00 92.42 N \\\\nATOM 2124 CA GLU A 267 1.410 -1.688 5.916 1.00 92.42 C \\\\nATOM 2125 C GLU A 267 2.337 -0.796 5.064 1.00 92.42 C \\\\nATOM 2126 CB GLU A 267 0.740 -0.852 7.025 1.00 92.42 C \\\\nATOM 2127 O GLU A 267 1.879 0.211 4.517 1.00 92.42 O \\\\nATOM 2128 CG GLU A 267 -0.372 -1.588 7.791 1.00 92.42 C \\\\nATOM 2129 CD GLU A 267 -0.968 -0.749 8.942 1.00 92.42 C \\\\nATOM 2130 OE1 GLU A 267 -1.641 -1.347 9.812 1.00 92.42 O \\\\nATOM 2131 OE2 GLU A 267 -0.756 0.490 8.978 1.00 92.42 O \\\\nATOM 2132 N ARG A 268 3.642 -1.106 4.951 1.00 96.71 N \\\\nATOM 2133 CA ARG A 268 4.633 -0.235 4.295 1.00 96.71 C \\\\nATOM 2134 C ARG A 268 5.581 -0.984 3.360 1.00 96.71 C \\\\nATOM 2135 CB ARG A 268 5.451 0.535 5.336 1.00 96.71 C \\\\nATOM 2136 O ARG A 268 6.459 -1.720 3.799 1.00 96.71 O \\\\nATOM 2137 CG ARG A 268 4.598 1.470 6.205 1.00 96.71 C \\\\nATOM 2138 CD ARG A 268 5.471 2.197 7.229 1.00 96.71 C \\\\nATOM 2139 NE ARG A 268 6.461 3.067 6.578 1.00 96.71 N \\\\nATOM 2140 NH1 ARG A 268 8.178 2.875 8.116 1.00 96.71 N \\\\nATOM 2141 NH2 ARG A 268 8.428 4.071 6.252 1.00 96.71 N \\\\nATOM 2142 CZ ARG A 268 7.677 3.330 7.000 1.00 96.71 C \\\\nATOM 2143 N PHE A 269 5.496 -0.685 2.067 1.00 97.68 N \\\\nATOM 2144 CA PHE A 269 6.505 -1.092 1.095 1.00 97.68 C \\\\nATOM 2145 C PHE A 269 7.594 -0.013 0.995 1.00 97.68 C \\\\nATOM 2146 CB PHE A 269 5.841 -1.419 -0.246 1.00 97.68 C \\\\nATOM 2147 O PHE A 269 7.465 0.977 0.272 1.00 97.68 O \\\\nATOM 2148 CG PHE A 269 6.732 -2.035 -1.317 1.00 97.68 C \\\\nATOM 2149 CD1 PHE A 269 6.290 -2.019 -2.654 1.00 97.68 C \\\\nATOM 2150 CD2 PHE A 269 7.951 -2.678 -1.003 1.00 97.68 C \\\\nATOM 2151 CE1 PHE A 269 7.051 -2.635 -3.663 1.00 97.68 C \\\\nATOM 2152 CE2 PHE A 269 8.709 -3.292 -2.014 1.00 97.68 C \\\\nATOM 2153 CZ PHE A 269 8.260 -3.274 -3.343 1.00 97.68 C \\\\nATOM 2154 N CYS A 270 8.660 -0.192 1.772 1.00 97.96 N \\\\nATOM 2155 CA CYS A 270 9.772 0.749 1.880 1.00 97.96 C \\\\nATOM 2156 C CYS A 270 10.801 0.547 0.756 1.00 97.96 C \\\\nATOM 2157 CB CYS A 270 10.393 0.560 3.264 1.00 97.96 C \\\\nATOM 2158 O CYS A 270 11.706 -0.278 0.855 1.00 97.96 O \\\\nATOM 2159 SG CYS A 270 9.279 1.227 4.523 1.00 97.96 S \\\\nATOM 2160 N LEU A 271 10.700 1.336 -0.313 1.00 98.37 N \\\\nATOM 2161 CA LEU A 271 11.570 1.252 -1.490 1.00 98.37 C \\\\nATOM 2162 C LEU A 271 13.017 1.677 -1.204 1.00 98.37 C \\\\nATOM 2163 CB LEU A 271 10.985 2.129 -2.613 1.00 98.37 C \\\\nATOM 2164 O LEU A 271 13.931 1.282 -1.934 1.00 98.37 O \\\\nATOM 2165 CG LEU A 271 9.530 1.812 -3.013 1.00 98.37 C \\\\nATOM 2166 CD1 LEU A 271 9.126 2.737 -4.161 1.00 98.37 C \\\\nATOM 2167 CD2 LEU A 271 9.361 0.360 -3.452 1.00 98.37 C \\\\nATOM 2168 N GLY A 272 13.246 2.484 -0.163 1.00 97.79 N \\\\nATOM 2169 CA GLY A 272 14.545 3.069 0.179 1.00 97.79 C \\\\nATOM 2170 C GLY A 272 15.617 2.040 0.545 1.00 97.79 C \\\\nATOM 2171 O GLY A 272 16.781 2.254 0.210 1.00 97.79 O \\\\nATOM 2172 N LEU A 273 15.226 0.906 1.141 1.00 96.65 N \\\\nATOM 2173 CA LEU A 273 16.139 -0.196 1.493 1.00 96.65 C \\\\nATOM 2174 C LEU A 273 16.521 -1.096 0.307 1.00 96.65 C \\\\nATOM 2175 CB LEU A 273 15.547 -1.007 2.665 1.00 96.65 C \\\\nATOM 2176 O LEU A 273 17.466 -1.872 0.412 1.00 96.65 O \\\\nATOM 2177 CG LEU A 273 14.300 -1.851 2.311 1.00 96.65 C \\\\nATOM 2178 CD1 LEU A 273 14.642 -3.321 2.064 1.00 96.65 C \\\\nATOM 2179 CD2 LEU A 273 13.283 -1.793 3.449 1.00 96.65 C \\\\nATOM 2180 N LEU A 274 15.799 -1.014 -0.815 1.00 97.53 N \\\\nATOM 2181 CA LEU A 274 16.035 -1.883 -1.966 1.00 97.53 C \\\\nATOM 2182 C LEU A 274 17.331 -1.493 -2.693 1.00 97.53 C \\\\nATOM 2183 CB LEU A 274 14.819 -1.875 -2.911 1.00 97.53 C \\\\nATOM 2184 O LEU A 274 17.503 -0.348 -3.127 1.00 97.53 O \\\\nATOM 2185 CG LEU A 274 13.475 -2.263 -2.261 1.00 97.53 C \\\\nATOM 2186 CD1 LEU A 274 12.360 -2.159 -3.298 1.00 97.53 C \\\\nATOM 2187 CD2 LEU A 274 13.486 -3.689 -1.708 1.00 97.53 C \\\\nATOM 2188 N SER A 275 18.231 -2.457 -2.866 1.00 97.29 N \\\\nATOM 2189 CA SER A 275 19.495 -2.297 -3.593 1.00 97.29 C \\\\nATOM 2190 C SER A 275 19.337 -2.595 -5.084 1.00 97.29 C \\\\nATOM 2191 CB SER A 275 20.570 -3.202 -2.989 1.00 97.29 C \\\\nATOM 2192 O SER A 275 18.613 -3.508 -5.468 1.00 97.29 O \\\\nATOM 2193 OG SER A 275 20.889 -2.729 -1.698 1.00 97.29 O \\\\nATOM 2194 N ASN A 276 20.062 -1.854 -5.922 1.00 97.60 N \\\\nATOM 2195 CA ASN A 276 20.222 -2.133 -7.348 1.00 97.60 C \\\\nATOM 2196 C ASN A 276 21.642 -1.728 -7.766 1.00 97.60 C \\\\nATOM 2197 CB ASN A 276 19.150 -1.372 -8.147 1.00 97.60 C \\\\nATOM 2198 O ASN A 276 22.036 -0.583 -7.550 1.00 97.60 O \\\\nATOM 2199 CG ASN A 276 19.281 -1.562 -9.649 1.00 97.60 C \\\\nATOM 2200 ND2 ASN A 276 18.599 -0.758 -10.423 1.00 97.60 N \\\\nATOM 2201 OD1 ASN A 276 20.009 -2.418 -10.132 1.00 97.60 O \\\\nATOM 2202 N VAL A 277 22.401 -2.660 -8.347 1.00 97.53 N \\\\nATOM 2203 CA VAL A 277 23.790 -2.432 -8.788 1.00 97.53 C \\\\nATOM 2204 C VAL A 277 23.883 -1.607 -10.075 1.00 97.53 C \\\\nATOM 2205 CB VAL A 277 24.560 -3.758 -8.942 1.00 97.53 C \\\\nATOM 2206 O VAL A 277 24.888 -0.944 -10.296 1.00 97.53 O \\\\nATOM 2207 CG1 VAL A 277 24.703 -4.463 -7.586 1.00 97.53 C \\\\nATOM 2208 CG2 VAL A 277 23.902 -4.734 -9.928 1.00 97.53 C \\\\nATOM 2209 N ASN A 278 22.820 -1.582 -10.886 1.00 97.11 N \\\\nATOM 2210 CA ASN A 278 22.754 -0.822 -12.142 1.00 97.11 C \\\\nATOM 2211 C ASN A 278 22.172 0.592 -11.951 1.00 97.11 C \\\\nATOM 2212 CB ASN A 278 21.926 -1.625 -13.154 1.00 97.11 C \\\\nATOM 2213 O ASN A 278 21.821 1.276 -12.916 1.00 97.11 O \\\\nATOM 2214 CG ASN A 278 22.476 -3.007 -13.444 1.00 97.11 C \\\\nATOM 2215 ND2 ASN A 278 21.611 -3.949 -13.725 1.00 97.11 N \\\\nATOM 2216 OD1 ASN A 278 23.666 -3.263 -13.422 1.00 97.11 O \\\\nATOM 2217 N ARG A 279 21.996 1.027 -10.698 1.00 97.96 N \\\\nATOM 2218 CA ARG A 279 21.340 2.290 -10.366 1.00 97.96 C \\\\nATOM 2219 C ARG A 279 22.193 3.478 -10.809 1.00 97.96 C \\\\nATOM 2220 CB ARG A 279 21.060 2.312 -8.863 1.00 97.96 C \\\\nATOM 2221 O ARG A 279 23.320 3.644 -10.360 1.00 97.96 O \\\\nATOM 2222 CG ARG A 279 20.244 3.545 -8.475 1.00 97.96 C \\\\nATOM 2223 CD ARG A 279 19.859 3.495 -6.999 1.00 97.96 C \\\\nATOM 2224 NE ARG A 279 18.879 2.424 -6.746 1.00 97.96 N \\\\nATOM 2225 NH1 ARG A 279 19.536 1.773 -4.627 1.00 97.96 N \\\\nATOM 2226 NH2 ARG A 279 17.786 0.836 -5.597 1.00 97.96 N \\\\nATOM 2227 CZ ARG A 279 18.752 1.686 -5.665 1.00 97.96 C \\\\nATOM 2228 N ASN A 280 21.625 4.343 -11.646 1.00 98.01 N \\\\nATOM 2229 CA ASN A 280 22.284 5.575 -12.082 1.00 98.01 C \\\\nATOM 2230 C ASN A 280 21.891 6.792 -11.219 1.00 98.01 C \\\\nATOM 2231 CB ASN A 280 22.066 5.759 -13.597 1.00 98.01 C \\\\nATOM 2232 O ASN A 280 20.905 6.771 -10.476 1.00 98.01 O \\\\nATOM 2233 CG ASN A 280 20.659 6.171 -13.997 1.00 98.01 C \\\\nATOM 2234 ND2 ASN A 280 20.158 5.652 -15.090 1.00 98.01 N \\\\nATOM 2235 OD1 ASN A 280 20.010 6.991 -13.367 1.00 98.01 O \\\\nATOM 2236 N ALA A 281 22.632 7.894 -11.368 1.00 98.22 N \\\\nATOM 2237 CA ALA A 281 22.433 9.122 -10.594 1.00 98.22 C \\\\nATOM 2238 C ALA A 281 21.018 9.732 -10.717 1.00 98.22 C \\\\nATOM 2239 CB ALA A 281 23.501 10.127 -11.044 1.00 98.22 C \\\\nATOM 2240 O ALA A 281 20.518 10.328 -9.762 1.00 98.22 O \\\\nATOM 2241 N ALA A 282 20.339 9.570 -11.860 1.00 97.51 N \\\\nATOM 2242 CA ALA A 282 18.974 10.067 -12.047 1.00 97.51 C \\\\nATOM 2243 C ALA A 282 17.950 9.249 -11.239 1.00 97.51 C \\\\nATOM 2244 CB ALA A 282 18.643 10.075 -13.544 1.00 97.51 C \\\\nATOM 2245 O ALA A 282 16.999 9.815 -10.689 1.00 97.51 O \\\\nATOM 2246 N VAL A 283 18.165 7.934 -11.122 1.00 98.47 N \\\\nATOM 2247 CA VAL A 283 17.389 7.047 -10.245 1.00 98.47 C \\\\nATOM 2248 C VAL A 283 17.664 7.375 -8.778 1.00 98.47 C \\\\nATOM 2249 CB VAL A 283 17.676 5.565 -10.555 1.00 98.47 C \\\\nATOM 2250 O VAL A 283 16.717 7.591 -8.027 1.00 98.47 O \\\\nATOM 2251 CG1 VAL A 283 16.889 4.649 -9.617 1.00 98.47 C \\\\nATOM 2252 CG2 VAL A 283 17.304 5.177 -11.993 1.00 98.47 C \\\\nATOM 2253 N GLU A 284 18.928 7.516 -8.364 1.00 98.10 N \\\\nATOM 2254 CA GLU A 284 19.264 7.908 -6.985 1.00 98.10 C \\\\nATOM 2255 C GLU A 284 18.616 9.230 -6.565 1.00 98.10 C \\\\nATOM 2256 CB GLU A 284 20.767 8.100 -6.802 1.00 98.10 C \\\\nATOM 2257 O GLU A 284 18.015 9.320 -5.492 1.00 98.10 O \\\\nATOM 2258 CG GLU A 284 21.591 6.819 -6.912 1.00 98.10 C \\\\nATOM 2259 CD GLU A 284 23.012 7.033 -6.376 1.00 98.10 C \\\\nATOM 2260 OE1 GLU A 284 23.693 6.005 -6.206 1.00 98.10 O \\\\nATOM 2261 OE2 GLU A 284 23.355 8.200 -6.052 1.00 98.10 O \\\\nATOM 2262 N LEU A 285 18.712 10.256 -7.416 1.00 97.88 N \\\\nATOM 2263 CA LEU A 285 18.103 11.557 -7.160 1.00 97.88 C \\\\nATOM 2264 C LEU A 285 16.577 11.448 -7.064 1.00 97.88 C \\\\nATOM 2265 CB LEU A 285 18.540 12.528 -8.271 1.00 97.88 C \\\\nATOM 2266 O LEU A 285 15.972 12.091 -6.209 1.00 97.88 O \\\\nATOM 2267 CG LEU A 285 18.038 13.971 -8.080 1.00 97.88 C \\\\nATOM 2268 CD1 LEU A 285 18.614 14.620 -6.819 1.00 97.88 C \\\\nATOM 2269 CD2 LEU A 285 18.441 14.815 -9.287 1.00 97.88 C \\\\nATOM 2270 N THR A 286 15.953 10.614 -7.899 1.00 98.50 N \\\\nATOM 2271 CA THR A 286 14.501 10.386 -7.877 1.00 98.50 C \\\\nATOM 2272 C THR A 286 14.064 9.674 -6.596 1.00 98.50 C \\\\nATOM 2273 CB THR A 286 14.054 9.625 -9.133 1.00 98.50 C \\\\nATOM 2274 O THR A 286 13.122 10.129 -5.949 1.00 98.50 O \\\\nATOM 2275 CG2 THR A 286 12.547 9.397 -9.178 1.00 98.50 C \\\\nATOM 2276 OG1 THR A 286 14.390 10.398 -10.269 1.00 98.50 O \\\\nATOM 2277 N ARG A 287 14.794 8.638 -6.154 1.00 98.55 N \\\\nATOM 2278 CA ARG A 287 14.523 7.904 -4.901 1.00 98.55 C \\\\nATOM 2279 C ARG A 287 14.482 8.822 -3.678 1.00 98.55 C \\\\nATOM 2280 CB ARG A 287 15.564 6.790 -4.704 1.00 98.55 C \\\\nATOM 2281 O ARG A 287 13.576 8.694 -2.859 1.00 98.55 O \\\\nATOM 2282 CG ARG A 287 15.359 5.631 -5.690 1.00 98.55 C \\\\nATOM 2283 CD ARG A 287 16.531 4.646 -5.688 1.00 98.55 C \\\\nATOM 2284 NE ARG A 287 16.726 3.989 -4.382 1.00 98.55 N \\\\nATOM 2285 NH1 ARG A 287 15.047 2.408 -4.548 1.00 98.55 N \\\\nATOM 2286 NH2 ARG A 287 16.237 2.559 -2.695 1.00 98.55 N \\\\nATOM 2287 CZ ARG A 287 16.004 2.997 -3.893 1.00 98.55 C \\\\nATOM 2288 N ARG A 288 15.396 9.799 -3.592 1.00 98.14 N \\\\nATOM 2289 CA ARG A 288 15.428 10.806 -2.505 1.00 98.14 C \\\\nATOM 2290 C ARG A 288 14.143 11.644 -2.420 1.00 98.14 C \\\\nATOM 2291 CB ARG A 288 16.650 11.731 -2.667 1.00 98.14 C \\\\nATOM 2292 O ARG A 288 13.778 12.070 -1.332 1.00 98.14 O \\\\nATOM 2293 CG ARG A 288 17.993 11.000 -2.498 1.00 98.14 C \\\\nATOM 2294 CD ARG A 288 19.181 11.901 -2.874 1.00 98.14 C \\\\nATOM 2295 NE ARG A 288 20.398 11.107 -3.150 1.00 98.14 N \\\\nATOM 2296 NH1 ARG A 288 21.675 12.765 -4.097 1.00 98.14 N \\\\nATOM 2297 NH2 ARG A 288 22.412 10.662 -4.146 1.00 98.14 N \\\\nATOM 2298 CZ ARG A 288 21.488 11.511 -3.787 1.00 98.14 C \\\\nATOM 2299 N HIS A 289 13.449 11.845 -3.541 1.00 98.35 N \\\\nATOM 2300 CA HIS A 289 12.217 12.635 -3.628 1.00 98.35 C \\\\nATOM 2301 C HIS A 289 10.932 11.800 -3.487 1.00 98.35 C \\\\nATOM 2302 CB HIS A 289 12.228 13.443 -4.933 1.00 98.35 C \\\\nATOM 2303 O HIS A 289 9.845 12.371 -3.441 1.00 98.35 O \\\\nATOM 2304 CG HIS A 289 13.279 14.519 -4.971 1.00 98.35 C \\\\nATOM 2305 CD2 HIS A 289 13.114 15.837 -4.644 1.00 98.35 C \\\\nATOM 2306 ND1 HIS A 289 14.587 14.359 -5.363 1.00 98.35 N \\\\nATOM 2307 CE1 HIS A 289 15.198 15.549 -5.271 1.00 98.35 C \\\\nATOM 2308 NE2 HIS A 289 14.339 16.483 -4.845 1.00 98.35 N \\\\nATOM 2309 N ILE A 290 11.017 10.466 -3.369 1.00 98.63 N \\\\nATOM 2310 CA ILE A 290 9.841 9.639 -3.050 1.00 98.63 C \\\\nATOM 2311 C ILE A 290 9.306 10.043 -1.671 1.00 98.63 C \\\\nATOM 2312 CB ILE A 290 10.157 8.125 -3.141 1.00 98.63 C \\\\nATOM 2313 O ILE A 290 8.115 10.314 -1.533 1.00 98.63 O \\\\nATOM 2314 CG1 ILE A 290 10.603 7.762 -4.577 1.00 98.63 C \\\\nATOM 2315 CG2 ILE A 290 8.930 7.285 -2.733 1.00 98.63 C \\\\nATOM 2316 CD1 ILE A 290 11.006 6.296 -4.777 1.00 98.63 C \\\\nATOM 2317 N GLY A 291 10.179 10.159 -0.662 1.00 97.93 N \\\\nATOM 2318 CA GLY A 291 9.796 10.581 0.688 1.00 97.93 C \\\\nATOM 2319 C GLY A 291 8.689 9.692 1.258 1.00 97.93 C \\\\nATOM 2320 O GLY A 291 8.837 8.476 1.311 1.00 97.93 O \\\\nATOM 2321 N ARG A 292 7.549 10.284 1.631 1.00 97.98 N \\\\nATOM 2322 CA ARG A 292 6.356 9.552 2.107 1.00 97.98 C \\\\nATOM 2323 C ARG A 292 5.579 8.813 1.001 1.00 97.98 C \\\\nATOM 2324 CB ARG A 292 5.429 10.523 2.843 1.00 97.98 C \\\\nATOM 2325 O ARG A 292 4.648 8.084 1.323 1.00 97.98 O \\\\nATOM 2326 CG ARG A 292 6.043 11.155 4.102 1.00 97.98 C \\\\nATOM 2327 CD ARG A 292 5.155 12.291 4.625 1.00 97.98 C \\\\nATOM 2328 NE ARG A 292 3.816 11.807 5.025 1.00 97.98 N \\\\nATOM 2329 NH1 ARG A 292 2.560 13.478 4.052 1.00 97.98 N \\\\nATOM 2330 NH2 ARG A 292 1.550 11.850 5.190 1.00 97.98 N \\\\nATOM 2331 CZ ARG A 292 2.657 12.386 4.757 1.00 97.98 C \\\\nATOM 2332 N GLY A 293 5.940 9.013 -0.267 1.00 98.48 N \\\\nATOM 2333 CA GLY A 293 5.458 8.255 -1.421 1.00 98.48 C \\\\nATOM 2334 C GLY A 293 3.948 8.325 -1.660 1.00 98.48 C \\\\nATOM 2335 O GLY A 293 3.371 9.413 -1.711 1.00 98.48 O \\\\nATOM 2336 N VAL A 294 3.316 7.167 -1.851 1.00 98.76 N \\\\nATOM 2337 CA VAL A 294 1.883 7.027 -2.148 1.00 98.76 C \\\\nATOM 2338 C VAL A 294 1.199 6.162 -1.095 1.00 98.76 C \\\\nATOM 2339 CB VAL A 294 1.649 6.501 -3.583 1.00 98.76 C \\\\nATOM 2340 O VAL A 294 1.681 5.080 -0.764 1.00 98.76 O \\\\nATOM 2341 CG1 VAL A 294 2.258 5.122 -3.865 1.00 98.76 C \\\\nATOM 2342 CG2 VAL A 294 0.160 6.438 -3.941 1.00 98.76 C \\\\nATOM 2343 N ARG A 295 0.049 6.616 -0.588 1.00 98.09 N \\\\nATOM 2344 CA ARG A 295 -0.880 5.762 0.159 1.00 98.09 C \\\\nATOM 2345 C ARG A 295 -1.883 5.153 -0.811 1.00 98.09 C \\\\nATOM 2346 CB ARG A 295 -1.528 6.533 1.317 1.00 98.09 C \\\\nATOM 2347 O ARG A 295 -2.517 5.875 -1.576 1.00 98.09 O \\\\nATOM 2348 CG ARG A 295 -2.630 5.709 1.999 1.00 98.09 C \\\\nATOM 2349 CD ARG A 295 -3.123 6.304 3.319 1.00 98.09 C \\\\nATOM 2350 NE ARG A 295 -3.835 7.594 3.177 1.00 98.09 N \\\\nATOM 2351 NH1 ARG A 295 -4.351 7.823 5.400 1.00 98.09 N \\\\nATOM 2352 NH2 ARG A 295 -4.968 9.401 4.026 1.00 98.09 N \\\\nATOM 2353 CZ ARG A 295 -4.365 8.267 4.180 1.00 98.09 C \\\\nATOM 2354 N LEU A 296 -2.036 3.839 -0.738 1.00 98.08 N \\\\nATOM 2355 CA LEU A 296 -3.010 3.062 -1.490 1.00 98.08 C \\\\nATOM 2356 C LEU A 296 -4.043 2.516 -0.509 1.00 98.08 C \\\\nATOM 2357 CB LEU A 296 -2.294 1.924 -2.231 1.00 98.08 C \\\\nATOM 2358 O LEU A 296 -3.667 2.012 0.551 1.00 98.08 O \\\\nATOM 2359 CG LEU A 296 -1.248 2.381 -3.261 1.00 98.08 C \\\\nATOM 2360 CD1 LEU A 296 -0.411 1.178 -3.685 1.00 98.08 C \\\\nATOM 2361 CD2 LEU A 296 -1.904 3.007 -4.492 1.00 98.08 C \\\\nATOM 2362 N TYR A 297 -5.329 2.623 -0.832 1.00 95.51 N \\\\nATOM 2363 CA TYR A 297 -6.385 2.059 0.007 1.00 95.51 C \\\\nATOM 2364 C TYR A 297 -7.529 1.468 -0.814 1.00 95.51 C \\\\nATOM 2365 CB TYR A 297 -6.864 3.077 1.057 1.00 95.51 C \\\\nATOM 2366 O TYR A 297 -7.959 2.065 -1.801 1.00 95.51 O \\\\nATOM 2367 CG TYR A 297 -7.340 4.429 0.545 1.00 95.51 C \\\\nATOM 2368 CD1 TYR A 297 -6.414 5.466 0.324 1.00 95.51 C \\\\nATOM 2369 CD2 TYR A 297 -8.708 4.666 0.320 1.00 95.51 C \\\\nATOM 2370 CE1 TYR A 297 -6.849 6.736 -0.100 1.00 95.51 C \\\\nATOM 2371 CE2 TYR A 297 -9.157 5.940 -0.083 1.00 95.51 C \\\\nATOM 2372 OH TYR A 297 -8.632 8.188 -0.768 1.00 95.51 O \\\\nATOM 2373 CZ TYR A 297 -8.223 6.975 -0.311 1.00 95.51 C \\\\nATOM 2374 N TYR A 298 -8.002 0.301 -0.375 1.00 94.74 N \\\\nATOM 2375 CA TYR A 298 -9.119 -0.454 -0.933 1.00 94.74 C \\\\nATOM 2376 C TYR A 298 -10.305 -0.400 0.031 1.00 94.74 C \\\\nATOM 2377 CB TYR A 298 -8.687 -1.901 -1.202 1.00 94.74 C \\\\nATOM 2378 O TYR A 298 -10.216 -0.871 1.165 1.00 94.74 O \\\\nATOM 2379 CG TYR A 298 -9.816 -2.794 -1.687 1.00 94.74 C \\\\nATOM 2380 CD1 TYR A 298 -10.159 -3.964 -0.979 1.00 94.74 C \\\\nATOM 2381 CD2 TYR A 298 -10.533 -2.448 -2.849 1.00 94.74 C \\\\nATOM 2382 CE1 TYR A 298 -11.210 -4.787 -1.436 1.00 94.74 C \\\\nATOM 2383 CE2 TYR A 298 -11.572 -3.276 -3.314 1.00 94.74 C \\\\nATOM 2384 OH TYR A 298 -12.949 -5.212 -3.055 1.00 94.74 O \\\\nATOM 2385 CZ TYR A 298 -11.919 -4.446 -2.607 1.00 94.74 C \\\\nATOM 2386 N ILE A 299 -11.394 0.244 -0.388 1.00 91.25 N \\\\nATOM 2387 CA ILE A 299 -12.558 0.535 0.455 1.00 91.25 C \\\\nATOM 2388 C ILE A 299 -13.815 0.469 -0.405 1.00 91.25 C \\\\nATOM 2389 CB ILE A 299 -12.423 1.927 1.118 1.00 91.25 C \\\\nATOM 2390 O ILE A 299 -13.893 1.129 -1.436 1.00 91.25 O \\\\nATOM 2391 CG1 ILE A 299 -11.142 1.993 1.981 1.00 91.25 C \\\\nATOM 2392 CG2 ILE A 299 -13.670 2.255 1.966 1.00 91.25 C \\\\nATOM 2393 CD1 ILE A 299 -10.920 3.332 2.662 1.00 91.25 C \\\\nATOM 2394 N GLY A 300 -14.817 -0.298 0.027 1.00 87.74 N \\\\nATOM 2395 CA GLY A 300 -16.122 -0.324 -0.635 1.00 87.74 C \\\\nATOM 2396 C GLY A 300 -16.095 -0.843 -2.079 1.00 87.74 C \\\\nATOM 2397 O GLY A 300 -16.918 -0.420 -2.883 1.00 87.74 O \\\\nATOM 2398 N GLY A 301 -15.134 -1.703 -2.439 1.00 92.50 N \\\\nATOM 2399 CA GLY A 301 -14.932 -2.138 -3.827 1.00 92.50 C \\\\nATOM 2400 C GLY A 301 -14.189 -1.123 -4.709 1.00 92.50 C \\\\nATOM 2401 O GLY A 301 -14.130 -1.302 -5.923 1.00 92.50 O \\\\nATOM 2402 N GLU A 302 -13.621 -0.061 -4.133 1.00 96.35 N \\\\nATOM 2403 CA GLU A 302 -12.888 0.985 -4.850 1.00 96.35 C \\\\nATOM 2404 C GLU A 302 -11.437 1.070 -4.369 1.00 96.35 C \\\\nATOM 2405 CB GLU A 302 -13.577 2.348 -4.682 1.00 96.35 C \\\\nATOM 2406 O GLU A 302 -11.167 0.962 -3.172 1.00 96.35 O \\\\nATOM 2407 CG GLU A 302 -15.088 2.312 -4.939 1.00 96.35 C \\\\nATOM 2408 CD GLU A 302 -15.652 3.709 -5.205 1.00 96.35 C \\\\nATOM 2409 OE1 GLU A 302 -16.276 3.889 -6.275 1.00 96.35 O \\\\nATOM 2410 OE2 GLU A 302 -15.407 4.677 -4.447 1.00 96.35 O \\\\nATOM 2411 N VAL A 303 -10.497 1.306 -5.288 1.00 97.65 N \\\\nATOM 2412 CA VAL A 303 -9.086 1.555 -4.958 1.00 97.65 C \\\\nATOM 2413 C VAL A 303 -8.758 3.017 -5.223 1.00 97.65 C \\\\nATOM 2414 CB VAL A 303 -8.101 0.632 -5.703 1.00 97.65 C \\\\nATOM 2415 O VAL A 303 -9.085 3.566 -6.279 1.00 97.65 O \\\\nATOM 2416 CG1 VAL A 303 -6.685 0.759 -5.122 1.00 97.65 C \\\\nATOM 2417 CG2 VAL A 303 -8.473 -0.853 -5.616 1.00 97.65 C \\\\nATOM 2418 N PHE A 304 -8.050 3.639 -4.287 1.00 98.07 N \\\\nATOM 2419 CA PHE A 304 -7.582 5.017 -4.387 1.00 98.07 C \\\\nATOM 2420 C PHE A 304 -6.065 5.109 -4.219 1.00 98.07 C \\\\nATOM 2421 CB PHE A 304 -8.259 5.861 -3.314 1.00 98.07 C \\\\nATOM 2422 O PHE A 304 -5.465 4.343 -3.462 1.00 98.07 O \\\\nATOM 2423 CG PHE A 304 -9.768 5.994 -3.396 1.00 98.07 C \\\\nATOM 2424 CD1 PHE A 304 -10.346 7.178 -3.895 1.00 98.07 C \\\\nATOM 2425 CD2 PHE A 304 -10.598 4.970 -2.898 1.00 98.07 C \\\\nATOM 2426 CE1 PHE A 304 -11.745 7.331 -3.908 1.00 98.07 C \\\\nATOM 2427 CE2 PHE A 304 -11.993 5.130 -2.902 1.00 98.07 C \\\\nATOM 2428 CZ PHE A 304 -12.568 6.303 -3.416 1.00 98.07 C \\\\nATOM 2429 N ALA A 305 -5.465 6.102 -4.876 1.00 98.57 N \\\\nATOM 2430 CA ALA A 305 -4.087 6.528 -4.654 1.00 98.57 C \\\\nATOM 2431 C ALA A 305 -4.061 7.952 -4.097 1.00 98.57 C \\\\nATOM 2432 CB ALA A 305 -3.307 6.433 -5.966 1.00 98.57 C \\\\nATOM 2433 O ALA A 305 -4.728 8.836 -4.629 1.00 98.57 O \\\\nATOM 2434 N GLU A 306 -3.273 8.188 -3.053 1.00 98.38 N \\\\nATOM 2435 CA GLU A 306 -3.106 9.485 -2.395 1.00 98.38 C \\\\nATOM 2436 C GLU A 306 -1.620 9.847 -2.324 1.00 98.38 C \\\\nATOM 2437 CB GLU A 306 -3.768 9.411 -1.014 1.00 98.38 C \\\\nATOM 2438 O GLU A 306 -0.812 9.109 -1.754 1.00 98.38 O \\\\nATOM 2439 CG GLU A 306 -3.686 10.690 -0.165 1.00 98.38 C \\\\nATOM 2440 CD GLU A 306 -4.307 10.462 1.224 1.00 98.38 C \\\\nATOM 2441 OE1 GLU A 306 -3.891 11.102 2.218 1.00 98.38 O \\\\nATOM 2442 OE2 GLU A 306 -5.160 9.553 1.396 1.00 98.38 O \\\\nATOM 2443 N CYS A 307 -1.250 10.987 -2.907 1.00 98.55 N \\\\nATOM 2444 CA CYS A 307 0.134 11.440 -2.960 1.00 98.55 C \\\\nATOM 2445 C CYS A 307 0.551 12.019 -1.602 1.00 98.55 C \\\\nATOM 2446 CB CYS A 307 0.277 12.448 -4.103 1.00 98.55 C \\\\nATOM 2447 O CYS A 307 0.202 13.148 -1.256 1.00 98.55 O \\\\nATOM 2448 SG CYS A 307 2.033 12.800 -4.388 1.00 98.55 S \\\\nATOM 2449 N LEU A 308 1.309 11.243 -0.824 1.00 98.21 N \\\\nATOM 2450 CA LEU A 308 1.869 11.676 0.458 1.00 98.21 C \\\\nATOM 2451 C LEU A 308 3.240 12.351 0.316 1.00 98.21 C \\\\nATOM 2452 CB LEU A 308 1.971 10.471 1.404 1.00 98.21 C \\\\nATOM 2453 O LEU A 308 3.667 13.040 1.247 1.00 98.21 O \\\\nATOM 2454 CG LEU A 308 0.651 9.781 1.786 1.00 98.21 C \\\\nATOM 2455 CD1 LEU A 308 0.945 8.821 2.942 1.00 98.21 C \\\\nATOM 2456 CD2 LEU A 308 -0.428 10.758 2.256 1.00 98.21 C \\\\nATOM 2457 N SER A 309 3.918 12.113 -0.808 1.00 98.38 N \\\\nATOM 2458 CA SER A 309 5.160 12.764 -1.220 1.00 98.38 C \\\\nATOM 2459 C SER A 309 4.962 14.255 -1.504 1.00 98.38 C \\\\nATOM 2460 CB SER A 309 5.692 12.085 -2.486 1.00 98.38 C \\\\nATOM 2461 O SER A 309 3.910 14.669 -1.993 1.00 98.38 O \\\\nATOM 2462 OG SER A 309 6.949 12.629 -2.837 1.00 98.38 O \\\\nATOM 2463 N ASP A 310 6.018 15.035 -1.266 1.00 98.37 N \\\\nATOM 2464 CA ASP A 310 6.132 16.441 -1.669 1.00 98.37 C \\\\nATOM 2465 C ASP A 310 6.377 16.594 -3.189 1.00 98.37 C \\\\nATOM 2466 CB ASP A 310 7.257 17.105 -0.855 1.00 98.37 C \\\\nATOM 2467 O ASP A 310 6.329 17.696 -3.731 1.00 98.37 O \\\\nATOM 2468 CG ASP A 310 7.108 16.885 0.657 1.00 98.37 C \\\\nATOM 2469 OD1 ASP A 310 6.020 17.183 1.199 1.00 98.37 O \\\\nATOM 2470 OD2 ASP A 310 8.070 16.356 1.258 1.00 98.37 O \\\\nATOM 2471 N SER A 311 6.618 15.485 -3.899 1.00 98.40 N \\\\nATOM 2472 CA SER A 311 6.662 15.398 -5.363 1.00 98.40 C \\\\nATOM 2473 C SER A 311 5.446 14.649 -5.905 1.00 98.40 C \\\\nATOM 2474 CB SER A 311 7.935 14.680 -5.804 1.00 98.40 C \\\\nATOM 2475 O SER A 311 5.000 13.672 -5.314 1.00 98.40 O \\\\nATOM 2476 OG SER A 311 9.054 15.498 -5.541 1.00 98.40 O \\\\nATOM 2477 N ALA A 312 4.929 15.070 -7.062 1.00 98.66 N \\\\nATOM 2478 CA ALA A 312 3.782 14.415 -7.693 1.00 98.66 C \\\\nATOM 2479 C ALA A 312 4.071 12.953 -8.088 1.00 98.66 C \\\\nATOM 2480 CB ALA A 312 3.342 15.240 -8.910 1.00 98.66 C \\\\nATOM 2481 O ALA A 312 5.201 12.598 -8.445 1.00 98.66 O \\\\nATOM 2482 N ILE A 313 3.015 12.141 -8.102 1.00 98.82 N \\\\nATOM 2483 CA ILE A 313 2.999 10.804 -8.707 1.00 98.82 C \\\\nATOM 2484 C ILE A 313 2.170 10.823 -9.996 1.00 98.82 C \\\\nATOM 2485 CB ILE A 313 2.538 9.719 -7.707 1.00 98.82 C \\\\nATOM 2486 O ILE A 313 1.347 11.714 -10.212 1.00 98.82 O \\\\nATOM 2487 CG1 ILE A 313 1.073 9.935 -7.277 1.00 98.82 C \\\\nATOM 2488 CG2 ILE A 313 3.504 9.665 -6.509 1.00 98.82 C \\\\nATOM 2489 CD1 ILE A 313 0.539 8.921 -6.265 1.00 98.82 C \\\\nATOM 2490 N PHE A 314 2.401 9.848 -10.865 1.00 98.73 N \\\\nATOM 2491 CA PHE A 314 1.799 9.763 -12.195 1.00 98.73 C \\\\nATOM 2492 C PHE A 314 1.232 8.361 -12.370 1.00 98.73 C \\\\nATOM 2493 CB PHE A 314 2.873 10.087 -13.242 1.00 98.73 C \\\\nATOM 2494 O PHE A 314 1.959 7.403 -12.131 1.00 98.73 O \\\\nATOM 2495 CG PHE A 314 3.483 11.464 -13.086 1.00 98.73 C \\\\nATOM 2496 CD1 PHE A 314 2.991 12.550 -13.832 1.00 98.73 C \\\\nATOM 2497 CD2 PHE A 314 4.534 11.664 -12.170 1.00 98.73 C \\\\nATOM 2498 CE1 PHE A 314 3.556 13.826 -13.660 1.00 98.73 C \\\\nATOM 2499 CE2 PHE A 314 5.066 12.949 -11.972 1.00 98.73 C \\\\nATOM 2500 CZ PHE A 314 4.588 14.029 -12.729 1.00 98.73 C \\\\nATOM 2501 N VAL A 315 -0.044 8.232 -12.728 1.00 98.59 N \\\\nATOM 2502 CA VAL A 315 -0.794 6.970 -12.686 1.00 98.59 C \\\\nATOM 2503 C VAL A 315 -1.401 6.660 -14.047 1.00 98.59 C \\\\nATOM 2504 CB VAL A 315 -1.905 7.017 -11.616 1.00 98.59 C \\\\nATOM 2505 O VAL A 315 -2.157 7.463 -14.581 1.00 98.59 O \\\\nATOM 2506 CG1 VAL A 315 -2.648 5.676 -11.526 1.00 98.59 C \\\\nATOM 2507 CG2 VAL A 315 -1.334 7.361 -10.232 1.00 98.59 C \\\\nATOM 2508 N GLN A 316 -1.131 5.467 -14.567 1.00 98.50 N \\\\nATOM 2509 CA GLN A 316 -1.849 4.879 -15.694 1.00 98.50 C \\\\nATOM 2510 C GLN A 316 -2.736 3.760 -15.142 1.00 98.50 C \\\\nATOM 2511 CB GLN A 316 -0.823 4.384 -16.721 1.00 98.50 C \\\\nATOM 2512 O GLN A 316 -2.234 2.719 -14.716 1.00 98.50 O \\\\nATOM 2513 CG GLN A 316 -1.429 3.791 -17.999 1.00 98.50 C \\\\nATOM 2514 CD GLN A 316 -0.336 3.221 -18.902 1.00 98.50 C \\\\nATOM 2515 NE2 GLN A 316 -0.040 3.836 -20.027 1.00 98.50 N \\\\nATOM 2516 OE1 GLN A 316 0.309 2.230 -18.589 1.00 98.50 O \\\\nATOM 2517 N SER A 317 -4.049 3.996 -15.117 1.00 98.39 N \\\\nATOM 2518 CA SER A 317 -5.060 2.984 -14.795 1.00 98.39 C \\\\nATOM 2519 C SER A 317 -6.089 2.946 -15.923 1.00 98.39 C \\\\nATOM 2520 CB SER A 317 -5.762 3.277 -13.467 1.00 98.39 C \\\\nATOM 2521 O SER A 317 -6.858 3.903 -16.054 1.00 98.39 O \\\\nATOM 2522 OG SER A 317 -6.874 2.408 -13.353 1.00 98.39 O \\\\nATOM 2523 N PRO A 318 -6.152 1.862 -16.715 1.00 97.77 N \\\\nATOM 2524 CA PRO A 318 -7.133 1.740 -17.789 1.00 97.77 C \\\\nATOM 2525 C PRO A 318 -8.589 1.853 -17.303 1.00 97.77 C \\\\nATOM 2526 CB PRO A 318 -6.821 0.396 -18.446 1.00 97.77 C \\\\nATOM 2527 O PRO A 318 -9.390 2.516 -17.953 1.00 97.77 O \\\\nATOM 2528 CG PRO A 318 -5.322 0.232 -18.214 1.00 97.77 C \\\\nATOM 2529 CD PRO A 318 -5.171 0.786 -16.801 1.00 97.77 C \\\\nATOM 2530 N ASN A 319 -8.918 1.326 -16.113 1.00 97.99 N \\\\nATOM 2531 CA ASN A 319 -10.244 1.493 -15.496 1.00 97.99 C \\\\nATOM 2532 C ASN A 319 -10.566 2.966 -15.183 1.00 97.99 C \\\\nATOM 2533 CB ASN A 319 -10.309 0.611 -14.236 1.00 97.99 C \\\\nATOM 2534 O ASN A 319 -11.661 3.438 -15.478 1.00 97.99 O \\\\nATOM 2535 CG ASN A 319 -11.614 0.775 -13.470 1.00 97.99 C \\\\nATOM 2536 ND2 ASN A 319 -12.663 0.081 -13.837 1.00 97.99 N \\\\nATOM 2537 OD1 ASN A 319 -11.698 1.547 -12.527 1.00 97.99 O \\\\nATOM 2538 N CYS A 320 -9.600 3.715 -14.641 1.00 97.61 N \\\\nATOM 2539 CA CYS A 320 -9.765 5.149 -14.404 1.00 97.61 C \\\\nATOM 2540 C CYS A 320 -9.915 5.926 -15.721 1.00 97.61 C \\\\nATOM 2541 CB CYS A 320 -8.560 5.644 -13.598 1.00 97.61 C \\\\nATOM 2542 O CYS A 320 -10.769 6.803 -15.818 1.00 97.61 O \\\\nATOM 2543 SG CYS A 320 -8.805 7.360 -13.069 1.00 97.61 S \\\\nATOM 2544 N ASN A 321 -9.107 5.597 -16.730 1.00 97.67 N \\\\nATOM 2545 CA ASN A 321 -9.126 6.263 -18.030 1.00 97.67 C \\\\nATOM 2546 C ASN A 321 -10.470 6.049 -18.742 1.00 97.67 C \\\\nATOM 2547 CB ASN A 321 -7.913 5.779 -18.849 1.00 97.67 C \\\\nATOM 2548 O ASN A 321 -11.088 7.022 -19.169 1.00 97.67 O \\\\nATOM 2549 CG ASN A 321 -6.587 6.264 -18.280 1.00 97.67 C \\\\nATOM 2550 ND2 ASN A 321 -5.481 5.659 -18.640 1.00 97.67 N \\\\nATOM 2551 OD1 ASN A 321 -6.511 7.213 -17.517 1.00 97.67 O \\\\nATOM 2552 N GLN A 322 -10.981 4.814 -18.757 1.00 96.68 N \\\\nATOM 2553 CA GLN A 322 -12.291 4.489 -19.322 1.00 96.68 C \\\\nATOM 2554 C GLN A 322 -13.438 5.228 -18.615 1.00 96.68 C \\\\nATOM 2555 CB GLN A 322 -12.479 2.967 -19.285 1.00 96.68 C \\\\nATOM 2556 O GLN A 322 -14.307 5.769 -19.296 1.00 96.68 O \\\\nATOM 2557 CG GLN A 322 -13.796 2.518 -19.940 1.00 96.68 C \\\\nATOM 2558 CD GLN A 322 -13.909 1.001 -20.053 1.00 96.68 C \\\\nATOM 2559 NE2 GLN A 322 -15.063 0.474 -20.393 1.00 96.68 N \\\\nATOM 2560 OE1 GLN A 322 -12.970 0.258 -19.833 1.00 96.68 O \\\\nATOM 2561 N ARG A 323 -13.426 5.330 -17.274 1.00 96.89 N \\\\nATOM 2562 CA ARG A 323 -14.443 6.083 -16.507 1.00 96.89 C \\\\nATOM 2563 C ARG A 323 -14.564 7.543 -16.958 1.00 96.89 C \\\\nATOM 2564 CB ARG A 323 -14.107 6.024 -15.006 1.00 96.89 C \\\\nATOM 2565 O ARG A 323 -15.663 8.090 -16.961 1.00 96.89 O \\\\nATOM 2566 CG ARG A 323 -15.199 6.657 -14.117 1.00 96.89 C \\\\nATOM 2567 CD ARG A 323 -14.716 6.904 -12.685 1.00 96.89 C \\\\nATOM 2568 NE ARG A 323 -14.325 5.643 -12.043 1.00 96.89 N \\\\nATOM 2569 NH1 ARG A 323 -12.182 6.137 -11.428 1.00 96.89 N \\\\nATOM 2570 NH2 ARG A 323 -12.918 4.017 -11.386 1.00 96.89 N \\\\nATOM 2571 CZ ARG A 323 -13.140 5.272 -11.615 1.00 96.89 C \\\\nATOM 2572 N TYR A 324 -13.446 8.175 -17.312 1.00 96.60 N \\\\nATOM 2573 CA TYR A 324 -13.397 9.579 -17.733 1.00 96.60 C \\\\nATOM 2574 C TYR A 324 -13.390 9.773 -19.261 1.00 96.60 C \\\\nATOM 2575 CB TYR A 324 -12.221 10.278 -17.032 1.00 96.60 C \\\\nATOM 2576 O TYR A 324 -13.228 10.900 -19.721 1.00 96.60 O \\\\nATOM 2577 CG TYR A 324 -12.352 10.360 -15.519 1.00 96.60 C \\\\nATOM 2578 CD1 TYR A 324 -13.401 11.106 -14.946 1.00 96.60 C \\\\nATOM 2579 CD2 TYR A 324 -11.424 9.710 -14.684 1.00 96.60 C \\\\nATOM 2580 CE1 TYR A 324 -13.535 11.186 -13.547 1.00 96.60 C \\\\nATOM 2581 CE2 TYR A 324 -11.555 9.779 -13.283 1.00 96.60 C \\\\nATOM 2582 OH TYR A 324 -12.750 10.575 -11.362 1.00 96.60 O \\\\nATOM 2583 CZ TYR A 324 -12.613 10.515 -12.714 1.00 96.60 C \\\\nATOM 2584 N GLY A 325 -13.566 8.706 -20.052 1.00 96.83 N \\\\nATOM 2585 CA GLY A 325 -13.546 8.778 -21.518 1.00 96.83 C \\\\nATOM 2586 C GLY A 325 -12.171 9.110 -22.114 1.00 96.83 C \\\\nATOM 2587 O GLY A 325 -12.085 9.595 -23.239 1.00 96.83 O \\\\nATOM 2588 N TRP A 326 -11.088 8.885 -21.368 1.00 96.86 N \\\\nATOM 2589 CA TRP A 326 -9.719 9.104 -21.832 1.00 96.86 C \\\\nATOM 2590 C TRP A 326 -9.160 7.863 -22.529 1.00 96.86 C \\\\nATOM 2591 CB TRP A 326 -8.824 9.520 -20.657 1.00 96.86 C \\\\nATOM 2592 O TRP A 326 -9.530 6.733 -22.211 1.00 96.86 O \\\\nATOM 2593 CG TRP A 326 -9.208 10.774 -19.932 1.00 96.86 C \\\\nATOM 2594 CD1 TRP A 326 -9.869 11.827 -20.467 1.00 96.86 C \\\\nATOM 2595 CD2 TRP A 326 -9.012 11.108 -18.521 1.00 96.86 C \\\\nATOM 2596 CE2 TRP A 326 -9.585 12.393 -18.279 1.00 96.86 C \\\\nATOM 2597 CE3 TRP A 326 -8.445 10.441 -17.410 1.00 96.86 C \\\\nATOM 2598 NE1 TRP A 326 -10.085 12.785 -19.500 1.00 96.86 N \\\\nATOM 2599 CH2 TRP A 326 -9.046 12.288 -15.922 1.00 96.86 C \\\\nATOM 2600 CZ2 TRP A 326 -9.597 12.988 -17.008 1.00 96.86 C \\\\nATOM 2601 CZ3 TRP A 326 -8.480 11.017 -16.125 1.00 96.86 C \\\\nATOM 2602 N HIS A 327 -8.192 8.071 -23.429 1.00 96.47 N \\\\nATOM 2603 CA HIS A 327 -7.456 6.975 -24.059 1.00 96.47 C \\\\nATOM 2604 C HIS A 327 -6.885 6.008 -22.993 1.00 96.47 C \\\\nATOM 2605 CB HIS A 327 -6.341 7.555 -24.942 1.00 96.47 C \\\\nATOM 2606 O HIS A 327 -6.330 6.481 -21.996 1.00 96.47 O \\\\nATOM 2607 CG HIS A 327 -5.666 6.498 -25.775 1.00 96.47 C \\\\nATOM 2608 CD2 HIS A 327 -6.181 5.901 -26.894 1.00 96.47 C \\\\nATOM 2609 ND1 HIS A 327 -4.451 5.902 -25.523 1.00 96.47 N \\\\nATOM 2610 CE1 HIS A 327 -4.247 4.955 -26.458 1.00 96.47 C \\\\nATOM 2611 NE2 HIS A 327 -5.285 4.912 -27.299 1.00 96.47 N \\\\nATOM 2612 N PRO A 328 -6.948 4.670 -23.168 1.00 94.55 N \\\\nATOM 2613 CA PRO A 328 -6.511 3.714 -22.142 1.00 94.55 C \\\\nATOM 2614 C PRO A 328 -5.063 3.912 -21.667 1.00 94.55 C \\\\nATOM 2615 CB PRO A 328 -6.707 2.331 -22.770 1.00 94.55 C \\\\nATOM 2616 O PRO A 328 -4.744 3.622 -20.514 1.00 94.55 O \\\\nATOM 2617 CG PRO A 328 -7.873 2.550 -23.731 1.00 94.55 C \\\\nATOM 2618 CD PRO A 328 -7.614 3.961 -24.254 1.00 94.55 C \\\\nATOM 2619 N ALA A 329 -4.203 4.470 -22.525 1.00 95.38 N \\\\nATOM 2620 CA ALA A 329 -2.805 4.780 -22.223 1.00 95.38 C \\\\nATOM 2621 C ALA A 329 -2.573 6.023 -21.339 1.00 95.38 C \\\\nATOM 2622 CB ALA A 329 -2.057 4.963 -23.546 1.00 95.38 C \\\\nATOM 2623 O ALA A 329 -1.431 6.232 -20.922 1.00 95.38 O \\\\nATOM 2624 N THR A 330 -3.592 6.859 -21.101 1.00 97.03 N \\\\nATOM 2625 CA THR A 330 -3.469 8.168 -20.437 1.00 97.03 C \\\\nATOM 2626 C THR A 330 -2.818 8.070 -19.056 1.00 97.03 C \\\\nATOM 2627 CB THR A 330 -4.839 8.868 -20.371 1.00 97.03 C \\\\nATOM 2628 O THR A 330 -3.058 7.131 -18.293 1.00 97.03 O \\\\nATOM 2629 CG2 THR A 330 -4.888 10.148 -19.534 1.00 97.03 C \\\\nATOM 2630 OG1 THR A 330 -5.162 9.258 -21.682 1.00 97.03 O \\\\nATOM 2631 N VAL A 331 -1.977 9.059 -18.743 1.00 98.32 N \\\\nATOM 2632 CA VAL A 331 -1.197 9.127 -17.503 1.00 98.32 C \\\\nATOM 2633 C VAL A 331 -1.662 10.319 -16.667 1.00 98.32 C \\\\nATOM 2634 CB VAL A 331 0.314 9.177 -17.801 1.00 98.32 C \\\\nATOM 2635 O VAL A 331 -1.331 11.473 -16.939 1.00 98.32 O \\\\nATOM 2636 CG1 VAL A 331 1.119 9.167 -16.496 1.00 98.32 C \\\\nATOM 2637 CG2 VAL A 331 0.754 7.971 -18.641 1.00 98.32 C \\\\nATOM 2638 N CYS A 332 -2.424 10.038 -15.616 1.00 97.93 N \\\\nATOM 2639 CA CYS A 332 -2.985 11.032 -14.711 1.00 97.93 C \\\\nATOM 2640 C CYS A 332 -1.943 11.484 -13.678 1.00 97.93 C \\\\nATOM 2641 CB CYS A 332 -4.212 10.433 -14.013 1.00 97.93 C \\\\nATOM 2642 O CYS A 332 -1.425 10.677 -12.904 1.00 97.93 O \\\\nATOM 2643 SG CYS A 332 -5.401 9.801 -15.228 1.00 97.93 S \\\\nATOM 2644 N LYS A 333 -1.662 12.786 -13.603 1.00 98.40 N \\\\nATOM 2645 CA LYS A 333 -0.823 13.367 -12.544 1.00 98.40 C \\\\nATOM 2646 C LYS A 333 -1.639 13.558 -11.262 1.00 98.40 C \\\\nATOM 2647 CB LYS A 333 -0.231 14.684 -13.062 1.00 98.40 C \\\\nATOM 2648 O LYS A 333 -2.661 14.236 -11.287 1.00 98.40 O \\\\nATOM 2649 CG LYS A 333 0.684 15.383 -12.046 1.00 98.40 C \\\\nATOM 2650 CD LYS A 333 1.203 16.686 -12.664 1.00 98.40 C \\\\nATOM 2651 CE LYS A 333 2.105 17.450 -11.694 1.00 98.40 C \\\\nATOM 2652 NZ LYS A 333 2.527 18.742 -12.291 1.00 98.40 N \\\\nATOM 2653 N ILE A 334 -1.145 13.050 -10.134 1.00 98.51 N \\\\nATOM 2654 CA ILE A 334 -1.685 13.314 -8.792 1.00 98.51 C \\\\nATOM 2655 C ILE A 334 -0.687 14.224 -8.050 1.00 98.51 C \\\\nATOM 2656 CB ILE A 334 -1.975 12.007 -8.019 1.00 98.51 C \\\\nATOM 2657 O ILE A 334 0.409 13.772 -7.703 1.00 98.51 O \\\\nATOM 2658 CG1 ILE A 334 -2.838 11.022 -8.842 1.00 98.51 C \\\\nATOM 2659 CG2 ILE A 334 -2.655 12.336 -6.674 1.00 98.51 C \\\\nATOM 2660 CD1 ILE A 334 -3.066 9.673 -8.151 1.00 98.51 C \\\\nATOM 2661 N PRO A 335 -1.013 15.514 -7.831 1.00 98.57 N \\\\nATOM 2662 CA PRO A 335 -0.159 16.433 -7.078 1.00 98.57 C \\\\nATOM 2663 C PRO A 335 -0.027 16.061 -5.586 1.00 98.57 C \\\\nATOM 2664 CB PRO A 335 -0.788 17.823 -7.244 1.00 98.57 C \\\\nATOM 2665 O PRO A 335 -0.885 15.351 -5.057 1.00 98.57 O \\\\nATOM 2666 CG PRO A 335 -1.649 17.696 -8.499 1.00 98.57 C \\\\nATOM 2667 CD PRO A 335 -2.117 16.247 -8.435 1.00 98.57 C \\\\nATOM 2668 N PRO A 336 0.997 16.579 -4.880 1.00 98.51 N \\\\nATOM 2669 CA PRO A 336 1.147 16.432 -3.429 1.00 98.51 C \\\\nATOM 2670 C PRO A 336 -0.131 16.770 -2.651 1.00 98.51 C \\\\nATOM 2671 CB PRO A 336 2.291 17.377 -3.044 1.00 98.51 C \\\\nATOM 2672 O PRO A 336 -0.737 17.819 -2.856 1.00 98.51 O \\\\nATOM 2673 CG PRO A 336 3.155 17.374 -4.300 1.00 98.51 C \\\\nATOM 2674 CD PRO A 336 2.115 17.342 -5.414 1.00 98.51 C \\\\nATOM 2675 N GLY A 337 -0.549 15.876 -1.752 1.00 95.96 N \\\\nATOM 2676 CA GLY A 337 -1.767 16.020 -0.948 1.00 95.96 C \\\\nATOM 2677 C GLY A 337 -3.084 15.715 -1.678 1.00 95.96 C \\\\nATOM 2678 O GLY A 337 -4.129 15.661 -1.028 1.00 95.96 O \\\\nATOM 2679 N CYS A 338 -3.066 15.485 -2.994 1.00 97.97 N \\\\nATOM 2680 CA CYS A 338 -4.239 15.055 -3.755 1.00 97.97 C \\\\nATOM 2681 C CYS A 338 -4.426 13.529 -3.706 1.00 97.97 C \\\\nATOM 2682 CB CYS A 338 -4.149 15.568 -5.200 1.00 97.97 C \\\\nATOM 2683 O CYS A 338 -3.501 12.769 -3.408 1.00 97.97 O \\\\nATOM 2684 SG CYS A 338 -4.101 17.385 -5.234 1.00 97.97 S \\\\nATOM 2685 N ASN A 339 -5.636 13.079 -4.040 1.00 97.19 N \\\\nATOM 2686 CA ASN A 339 -5.968 11.670 -4.234 1.00 97.19 C \\\\nATOM 2687 C ASN A 339 -6.816 11.470 -5.499 1.00 97.19 C \\\\nATOM 2688 CB ASN A 339 -6.641 11.094 -2.973 1.00 97.19 C \\\\nATOM 2689 O ASN A 339 -7.424 12.420 -5.991 1.00 97.19 O \\\\nATOM 2690 CG ASN A 339 -8.006 11.697 -2.697 1.00 97.19 C \\\\nATOM 2691 ND2 ASN A 339 -8.068 12.787 -1.966 1.00 97.19 N \\\\nATOM 2692 OD1 ASN A 339 -9.032 11.213 -3.137 1.00 97.19 O \\\\nATOM 2693 N LEU A 340 -6.834 10.241 -6.013 1.00 97.74 N \\\\nATOM 2694 CA LEU A 340 -7.588 9.821 -7.194 1.00 97.74 C \\\\nATOM 2695 C LEU A 340 -8.170 8.421 -6.967 1.00 97.74 C \\\\nATOM 2696 CB LEU A 340 -6.636 9.839 -8.406 1.00 97.74 C \\\\nATOM 2697 O LEU A 340 -7.485 7.548 -6.431 1.00 97.74 O \\\\nATOM 2698 CG LEU A 340 -7.252 9.450 -9.765 1.00 97.74 C \\\\nATOM 2699 CD1 LEU A 340 -8.359 10.414 -10.195 1.00 97.74 C \\\\nATOM 2700 CD2 LEU A 340 -6.159 9.459 -10.835 1.00 97.74 C \\\\nATOM 2701 N LYS A 341 -9.407 8.188 -7.420 1.00 97.97 N \\\\nATOM 2702 CA LYS A 341 -10.010 6.849 -7.498 1.00 97.97 C \\\\nATOM 2703 C LYS A 341 -9.441 6.115 -8.710 1.00 97.97 C \\\\nATOM 2704 CB LYS A 341 -11.538 6.971 -7.566 1.00 97.97 C \\\\nATOM 2705 O LYS A 341 -9.873 6.340 -9.838 1.00 97.97 O \\\\nATOM 2706 CG LYS A 341 -12.210 5.588 -7.497 1.00 97.97 C \\\\nATOM 2707 CD LYS A 341 -13.726 5.666 -7.704 1.00 97.97 C \\\\nATOM 2708 CE LYS A 341 -14.397 6.548 -6.645 1.00 97.97 C \\\\nATOM 2709 NZ LYS A 341 -15.870 6.475 -6.744 1.00 97.97 N \\\\nATOM 2710 N ILE A 342 -8.457 5.254 -8.483 1.00 98.34 N \\\\nATOM 2711 CA ILE A 342 -7.732 4.562 -9.552 1.00 98.34 C \\\\nATOM 2712 C ILE A 342 -8.460 3.309 -10.050 1.00 98.34 C \\\\nATOM 2713 CB ILE A 342 -6.280 4.249 -9.132 1.00 98.34 C \\\\nATOM 2714 O ILE A 342 -8.189 2.889 -11.168 1.00 98.34 O \\\\nATOM 2715 CG1 ILE A 342 -6.231 3.224 -7.976 1.00 98.34 C \\\\nATOM 2716 CG2 ILE A 342 -5.535 5.553 -8.793 1.00 98.34 C \\\\nATOM 2717 CD1 ILE A 342 -4.827 2.765 -7.596 1.00 98.34 C \\\\nATOM 2718 N PHE A 343 -9.368 2.720 -9.264 1.00 98.38 N \\\\nATOM 2719 CA PHE A 343 -10.139 1.539 -9.668 1.00 98.38 C \\\\nATOM 2720 C PHE A 343 -11.522 1.488 -9.004 1.00 98.38 C \\\\nATOM 2721 CB PHE A 343 -9.354 0.262 -9.343 1.00 98.38 C \\\\nATOM 2722 O PHE A 343 -11.668 1.935 -7.865 1.00 98.38 O \\\\nATOM 2723 CG PHE A 343 -9.807 -0.946 -10.137 1.00 98.38 C \\\\nATOM 2724 CD1 PHE A 343 -10.721 -1.865 -9.586 1.00 98.38 C \\\\nATOM 2725 CD2 PHE A 343 -9.294 -1.165 -11.430 1.00 98.38 C \\\\nATOM 2726 CE1 PHE A 343 -11.108 -2.997 -10.323 1.00 98.38 C \\\\nATOM 2727 CE2 PHE A 343 -9.684 -2.301 -12.160 1.00 98.38 C \\\\nATOM 2728 CZ PHE A 343 -10.580 -3.224 -11.602 1.00 98.38 C \\\\nATOM 2729 N ASN A 344 -12.511 0.898 -9.675 1.00 96.95 N \\\\nATOM 2730 CA ASN A 344 -13.810 0.538 -9.101 1.00 96.95 C \\\\nATOM 2731 C ASN A 344 -14.249 -0.852 -9.617 1.00 96.95 C \\\\nATOM 2732 CB ASN A 344 -14.811 1.671 -9.406 1.00 96.95 C \\\\nATOM 2733 O ASN A 344 -14.299 -1.098 -10.824 1.00 96.95 O \\\\nATOM 2734 CG ASN A 344 -16.252 1.329 -9.067 1.00 96.95 C \\\\nATOM 2735 ND2 ASN A 344 -16.917 2.009 -8.169 1.00 96.95 N \\\\nATOM 2736 OD1 ASN A 344 -16.815 0.393 -9.597 1.00 96.95 O \\\\nATOM 2737 N ASN A 345 -14.585 -1.756 -8.691 1.00 95.65 N \\\\nATOM 2738 CA ASN A 345 -14.955 -3.140 -8.994 1.00 95.65 C \\\\nATOM 2739 C ASN A 345 -16.313 -3.279 -9.705 1.00 95.65 C \\\\nATOM 2740 CB ASN A 345 -14.978 -3.970 -7.695 1.00 95.65 C \\\\nATOM 2741 O ASN A 345 -16.496 -4.245 -10.438 1.00 95.65 O \\\\nATOM 2742 CG ASN A 345 -13.622 -4.311 -7.098 1.00 95.65 C \\\\nATOM 2743 ND2 ASN A 345 -13.616 -5.022 -5.996 1.00 95.65 N \\\\nATOM 2744 OD1 ASN A 345 -12.567 -3.976 -7.606 1.00 95.65 O \\\\nATOM 2745 N GLN A 346 -17.266 -2.360 -9.509 1.00 95.14 N \\\\nATOM 2746 CA GLN A 346 -18.570 -2.389 -10.192 1.00 95.14 C \\\\nATOM 2747 C GLN A 346 -18.434 -2.020 -11.675 1.00 95.14 C \\\\nATOM 2748 CB GLN A 346 -19.572 -1.432 -9.520 1.00 95.14 C \\\\nATOM 2749 O GLN A 346 -19.045 -2.656 -12.528 1.00 95.14 O \\\\nATOM 2750 CG GLN A 346 -19.850 -1.744 -8.045 1.00 95.14 C \\\\nATOM 2751 CD GLN A 346 -20.867 -0.771 -7.458 1.00 95.14 C \\\\nATOM 2752 NE2 GLN A 346 -21.978 -1.246 -6.939 1.00 95.14 N \\\\nATOM 2753 OE1 GLN A 346 -20.692 0.434 -7.453 1.00 95.14 O \\\\nATOM 2754 N GLU A 347 -17.593 -1.034 -11.990 1.00 95.97 N \\\\nATOM 2755 CA GLU A 347 -17.256 -0.657 -13.367 1.00 95.97 C \\\\nATOM 2756 C GLU A 347 -16.535 -1.805 -14.087 1.00 95.97 C \\\\nATOM 2757 CB GLU A 347 -16.368 0.596 -13.346 1.00 95.97 C \\\\nATOM 2758 O GLU A 347 -16.882 -2.144 -15.217 1.00 95.97 O \\\\nATOM 2759 CG GLU A 347 -17.108 1.858 -12.867 1.00 95.97 C \\\\nATOM 2760 CD GLU A 347 -16.146 3.008 -12.540 1.00 95.97 C \\\\nATOM 2761 OE1 GLU A 347 -16.567 4.018 -11.935 1.00 95.97 O \\\\nATOM 2762 OE2 GLU A 347 -14.927 2.898 -12.799 1.00 95.97 O \\\\nATOM 2763 N PHE A 348 -15.586 -2.464 -13.409 1.00 97.03 N \\\\nATOM 2764 CA PHE A 348 -14.939 -3.667 -13.936 1.00 97.03 C \\\\nATOM 2765 C PHE A 348 -15.919 -4.841 -14.102 1.00 97.03 C \\\\nATOM 2766 CB PHE A 348 -13.752 -4.044 -13.043 1.00 97.03 C \\\\nATOM 2767 O PHE A 348 -15.876 -5.515 -15.126 1.00 97.03 O \\\\nATOM 2768 CG PHE A 348 -13.012 -5.279 -13.524 1.00 97.03 C \\\\nATOM 2769 CD1 PHE A 348 -13.244 -6.527 -12.912 1.00 97.03 C \\\\nATOM 2770 CD2 PHE A 348 -12.127 -5.191 -14.616 1.00 97.03 C \\\\nATOM 2771 CE1 PHE A 348 -12.591 -7.679 -13.387 1.00 97.03 C \\\\nATOM 2772 CE2 PHE A 348 -11.474 -6.344 -15.089 1.00 97.03 C \\\\nATOM 2773 CZ PHE A 348 -11.706 -7.586 -14.474 1.00 97.03 C \\\\nATOM 2774 N ALA A 349 -16.836 -5.061 -13.151 1.00 95.38 N \\\\nATOM 2775 CA ALA A 349 -17.877 -6.089 -13.243 1.00 95.38 C \\\\nATOM 2776 C ALA A 349 -18.769 -5.904 -14.478 1.00 95.38 C \\\\nATOM 2777 CB ALA A 349 -18.758 -6.034 -11.985 1.00 95.38 C \\\\nATOM 2778 O ALA A 349 -19.033 -6.861 -15.205 1.00 95.38 O \\\\nATOM 2779 N ALA A 350 -19.224 -4.669 -14.713 1.00 95.44 N \\\\nATOM 2780 CA ALA A 350 -20.069 -4.329 -15.850 1.00 95.44 C \\\\nATOM 2781 C ALA A 350 -19.336 -4.555 -17.180 1.00 95.44 C \\\\nATOM 2782 CB ALA A 350 -20.535 -2.877 -15.689 1.00 95.44 C \\\\nATOM 2783 O ALA A 350 -19.901 -5.157 -18.091 1.00 95.44 O \\\\nATOM 2784 N LEU A 351 -18.068 -4.140 -17.268 1.00 95.45 N \\\\nATOM 2785 CA LEU A 351 -17.235 -4.369 -18.446 1.00 95.45 C \\\\nATOM 2786 C LEU A 351 -16.982 -5.863 -18.691 1.00 95.45 C \\\\nATOM 2787 CB LEU A 351 -15.927 -3.589 -18.264 1.00 95.45 C \\\\nATOM 2788 O LEU A 351 -17.164 -6.335 -19.808 1.00 95.45 O \\\\nATOM 2789 CG LEU A 351 -14.970 -3.702 -19.462 1.00 95.45 C \\\\nATOM 2790 CD1 LEU A 351 -15.584 -3.164 -20.755 1.00 95.45 C \\\\nATOM 2791 CD2 LEU A 351 -13.718 -2.901 -19.127 1.00 95.45 C \\\\nATOM 2792 N LEU A 352 -16.637 -6.626 -17.649 1.00 96.13 N \\\\nATOM 2793 CA LEU A 352 -16.427 -8.072 -17.739 1.00 96.13 C \\\\nATOM 2794 C LEU A 352 -17.687 -8.794 -18.240 1.00 96.13 C \\\\nATOM 2795 CB LEU A 352 -15.943 -8.577 -16.365 1.00 96.13 C \\\\nATOM 2796 O LEU A 352 -17.603 -9.603 -19.160 1.00 96.13 O \\\\nATOM 2797 CG LEU A 352 -15.683 -10.092 -16.272 1.00 96.13 C \\\\nATOM 2798 CD1 LEU A 352 -14.689 -10.587 -17.318 1.00 96.13 C \\\\nATOM 2799 CD2 LEU A 352 -15.118 -10.422 -14.887 1.00 96.13 C \\\\nATOM 2800 N ALA A 353 -18.862 -8.453 -17.703 1.00 94.39 N \\\\nATOM 2801 CA ALA A 353 -20.137 -9.006 -18.157 1.00 94.39 C \\\\nATOM 2802 C ALA A 353 -20.473 -8.643 -19.618 1.00 94.39 C \\\\nATOM 2803 CB ALA A 353 -21.234 -8.528 -17.198 1.00 94.39 C \\\\nATOM 2804 O ALA A 353 -21.095 -9.440 -20.318 1.00 94.39 O \\\\nATOM 2805 N GLN A 354 -20.057 -7.466 -20.099 1.00 94.04 N \\\\nATOM 2806 CA GLN A 354 -20.220 -7.067 -21.500 1.00 94.04 C \\\\nATOM 2807 C GLN A 354 -19.262 -7.839 -22.420 1.00 94.04 C \\\\nATOM 2808 CB GLN A 354 -20.038 -5.547 -21.636 1.00 94.04 C \\\\nATOM 2809 O GLN A 354 -19.718 -8.442 -23.394 1.00 94.04 O \\\\nATOM 2810 CG GLN A 354 -21.235 -4.775 -21.055 1.00 94.04 C \\\\nATOM 2811 CD GLN A 354 -20.982 -3.275 -20.915 1.00 94.04 C \\\\nATOM 2812 NE2 GLN A 354 -21.886 -2.546 -20.298 1.00 94.04 N \\\\nATOM 2813 OE1 GLN A 354 -19.994 -2.713 -21.353 1.00 94.04 O \\\\nATOM 2814 N SER A 355 -17.968 -7.887 -22.088 1.00 94.46 N \\\\nATOM 2815 CA SER A 355 -16.929 -8.520 -22.912 1.00 94.46 C \\\\nATOM 2816 C SER A 355 -17.077 -10.034 -23.059 1.00 94.46 C \\\\nATOM 2817 CB SER A 355 -15.537 -8.197 -22.368 1.00 94.46 C \\\\nATOM 2818 O SER A 355 -16.649 -10.571 -24.074 1.00 94.46 O \\\\nATOM 2819 OG SER A 355 -15.291 -6.809 -22.469 1.00 94.46 O \\\\nATOM 2820 N VAL A 356 -17.745 -10.732 -22.131 1.00 92.71 N \\\\nATOM 2821 CA VAL A 356 -18.093 -12.160 -22.307 1.00 92.71 C \\\\nATOM 2822 C VAL A 356 -18.860 -12.407 -23.613 1.00 92.71 C \\\\nATOM 2823 CB VAL A 356 -18.887 -12.669 -21.087 1.00 92.71 C \\\\nATOM 2824 O VAL A 356 -18.597 -13.386 -24.306 1.00 92.71 O \\\\nATOM 2825 CG1 VAL A 356 -19.590 -14.012 -21.311 1.00 92.71 C \\\\nATOM 2826 CG2 VAL A 356 -17.941 -12.871 -19.900 1.00 92.71 C \\\\nATOM 2827 N ASN A 357 -19.745 -11.487 -24.013 1.00 89.37 N \\\\nATOM 2828 CA ASN A 357 -20.513 -11.601 -25.261 1.00 89.37 C \\\\nATOM 2829 C ASN A 357 -19.690 -11.255 -26.519 1.00 89.37 C \\\\nATOM 2830 CB ASN A 357 -21.776 -10.732 -25.163 1.00 89.37 C \\\\nATOM 2831 O ASN A 357 -20.150 -11.488 -27.633 1.00 89.37 O \\\\nATOM 2832 CG ASN A 357 -22.604 -11.057 -23.936 1.00 89.37 C \\\\nATOM 2833 ND2 ASN A 357 -22.554 -10.217 -22.930 1.00 89.37 N \\\\nATOM 2834 OD1 ASN A 357 -23.262 -12.078 -23.847 1.00 89.37 O \\\\nATOM 2835 N GLN A 358 -18.487 -10.699 -26.346 1.00 91.08 N \\\\nATOM 2836 CA GLN A 358 -17.529 -10.374 -27.411 1.00 91.08 C \\\\nATOM 2837 C GLN A 358 -16.492 -11.499 -27.621 1.00 91.08 C \\\\nATOM 2838 CB GLN A 358 -16.841 -9.038 -27.074 1.00 91.08 C \\\\nATOM 2839 O GLN A 358 -15.707 -11.448 -28.566 1.00 91.08 O \\\\nATOM 2840 CG GLN A 358 -17.800 -7.840 -26.950 1.00 91.08 C \\\\nATOM 2841 CD GLN A 358 -17.139 -6.596 -26.353 1.00 91.08 C \\\\nATOM 2842 NE2 GLN A 358 -17.807 -5.465 -26.381 1.00 91.08 N \\\\nATOM 2843 OE1 GLN A 358 -16.049 -6.607 -25.801 1.00 91.08 O \\\\nATOM 2844 N GLY A 359 -16.494 -12.529 -26.765 1.00 90.37 N \\\\nATOM 2845 CA GLY A 359 -15.665 -13.728 -26.894 1.00 90.37 C \\\\nATOM 2846 C GLY A 359 -14.324 -13.684 -26.151 1.00 90.37 C \\\\nATOM 2847 O GLY A 359 -14.008 -12.750 -25.412 1.00 90.37 O \\\\nATOM 2848 N PHE A 360 -13.531 -14.747 -26.339 1.00 90.85 N \\\\nATOM 2849 CA PHE A 360 -12.313 -15.020 -25.561 1.00 90.85 C \\\\nATOM 2850 C PHE A 360 -11.310 -13.865 -25.550 1.00 90.85 C \\\\nATOM 2851 CB PHE A 360 -11.668 -16.329 -26.041 1.00 90.85 C \\\\nATOM 2852 O PHE A 360 -10.863 -13.465 -24.477 1.00 90.85 O \\\\nATOM 2853 CG PHE A 360 -10.561 -16.809 -25.121 1.00 90.85 C \\\\nATOM 2854 CD1 PHE A 360 -9.265 -16.267 -25.227 1.00 90.85 C \\\\nATOM 2855 CD2 PHE A 360 -10.837 -17.763 -24.121 1.00 90.85 C \\\\nATOM 2856 CE1 PHE A 360 -8.253 -16.670 -24.338 1.00 90.85 C \\\\nATOM 2857 CE2 PHE A 360 -9.824 -18.168 -23.234 1.00 90.85 C \\\\nATOM 2858 CZ PHE A 360 -8.532 -17.623 -23.343 1.00 90.85 C \\\\nATOM 2859 N GLU A 361 -10.982 -13.310 -26.717 1.00 91.71 N \\\\nATOM 2860 CA GLU A 361 -9.951 -12.274 -26.825 1.00 91.71 C \\\\nATOM 2861 C GLU A 361 -10.351 -10.987 -26.091 1.00 91.71 C \\\\nATOM 2862 CB GLU A 361 -9.656 -12.018 -28.313 1.00 91.71 C \\\\nATOM 2863 O GLU A 361 -9.552 -10.427 -25.345 1.00 91.71 O \\\\nATOM 2864 CG GLU A 361 -8.429 -11.123 -28.545 1.00 91.71 C \\\\nATOM 2865 CD GLU A 361 -7.154 -11.667 -27.883 1.00 91.71 C \\\\nATOM 2866 OE1 GLU A 361 -6.342 -10.831 -27.422 1.00 91.71 O \\\\nATOM 2867 OE2 GLU A 361 -7.010 -12.908 -27.800 1.00 91.71 O \\\\nATOM 2868 N ALA A 362 -11.613 -10.562 -26.213 1.00 93.21 N \\\\nATOM 2869 CA ALA A 362 -12.117 -9.369 -25.538 1.00 93.21 C \\\\nATOM 2870 C ALA A 362 -11.999 -9.481 -24.010 1.00 93.21 C \\\\nATOM 2871 CB ALA A 362 -13.566 -9.150 -25.973 1.00 93.21 C \\\\nATOM 2872 O ALA A 362 -11.527 -8.553 -23.355 1.00 93.21 O \\\\nATOM 2873 N VAL A 363 -12.357 -10.639 -23.441 1.00 93.93 N \\\\nATOM 2874 CA VAL A 363 -12.168 -10.907 -22.007 1.00 93.93 C \\\\nATOM 2875 C VAL A 363 -10.682 -11.016 -21.660 1.00 93.93 C \\\\nATOM 2876 CB VAL A 363 -12.953 -12.156 -21.569 1.00 93.93 C \\\\nATOM 2877 O VAL A 363 -10.252 -10.433 -20.670 1.00 93.93 O \\\\nATOM 2878 CG1 VAL A 363 -12.751 -12.502 -20.091 1.00 93.93 C \\\\nATOM 2879 CG2 VAL A 363 -14.456 -11.915 -21.749 1.00 93.93 C \\\\nATOM 2880 N TYR A 364 -9.862 -11.685 -22.472 1.00 93.20 N \\\\nATOM 2881 CA TYR A 364 -8.427 -11.825 -22.207 1.00 93.20 C \\\\nATOM 2882 C TYR A 364 -7.715 -10.462 -22.122 1.00 93.20 C \\\\nATOM 2883 CB TYR A 364 -7.800 -12.732 -23.272 1.00 93.20 C \\\\nATOM 2884 O TYR A 364 -6.920 -10.228 -21.204 1.00 93.20 O \\\\nATOM 2885 CG TYR A 364 -6.345 -13.042 -22.995 1.00 93.20 C \\\\nATOM 2886 CD1 TYR A 364 -5.330 -12.355 -23.688 1.00 93.20 C \\\\nATOM 2887 CD2 TYR A 364 -6.013 -13.994 -22.012 1.00 93.20 C \\\\nATOM 2888 CE1 TYR A 364 -3.979 -12.605 -23.380 1.00 93.20 C \\\\nATOM 2889 CE2 TYR A 364 -4.663 -14.253 -21.707 1.00 93.20 C \\\\nATOM 2890 OH TYR A 364 -2.341 -13.787 -22.088 1.00 93.20 O \\\\nATOM 2891 CZ TYR A 364 -3.645 -13.550 -22.388 1.00 93.20 C \\\\nATOM 2892 N GLN A 365 -8.072 -9.512 -22.994 1.00 93.42 N \\\\nATOM 2893 CA GLN A 365 -7.553 -8.140 -22.965 1.00 93.42 C \\\\nATOM 2894 C GLN A 365 -7.907 -7.379 -21.672 1.00 93.42 C \\\\nATOM 2895 CB GLN A 365 -8.040 -7.370 -24.206 1.00 93.42 C \\\\nATOM 2896 O GLN A 365 -7.131 -6.515 -21.249 1.00 93.42 O \\\\nATOM 2897 CG GLN A 365 -7.428 -7.884 -25.524 1.00 93.42 C \\\\nATOM 2898 CD GLN A 365 -5.914 -7.725 -25.629 1.00 93.42 C \\\\nATOM 2899 NE2 GLN A 365 -5.257 -8.548 -26.410 1.00 93.42 N \\\\nATOM 2900 OE1 GLN A 365 -5.283 -6.872 -25.015 1.00 93.42 O \\\\nATOM 2901 N LEU A 366 -8.993 -7.738 -20.967 1.00 95.17 N \\\\nATOM 2902 CA LEU A 366 -9.334 -7.145 -19.664 1.00 95.17 C \\\\nATOM 2903 C LEU A 366 -8.290 -7.423 -18.574 1.00 95.17 C \\\\nATOM 2904 CB LEU A 366 -10.722 -7.583 -19.165 1.00 95.17 C \\\\nATOM 2905 O LEU A 366 -8.277 -6.712 -17.570 1.00 95.17 O \\\\nATOM 2906 CG LEU A 366 -11.909 -7.249 -20.080 1.00 95.17 C \\\\nATOM 2907 CD1 LEU A 366 -13.200 -7.665 -19.379 1.00 95.17 C \\\\nATOM 2908 CD2 LEU A 366 -11.996 -5.757 -20.398 1.00 95.17 C \\\\nATOM 2909 N THR A 367 -7.352 -8.355 -18.783 1.00 95.31 N \\\\nATOM 2910 CA THR A 367 -6.177 -8.527 -17.907 1.00 95.31 C \\\\nATOM 2911 C THR A 367 -5.436 -7.198 -17.716 1.00 95.31 C \\\\nATOM 2912 CB THR A 367 -5.206 -9.573 -18.482 1.00 95.31 C \\\\nATOM 2913 O THR A 367 -5.001 -6.880 -16.610 1.00 95.31 O \\\\nATOM 2914 CG2 THR A 367 -4.080 -9.922 -17.507 1.00 95.31 C \\\\nATOM 2915 OG1 THR A 367 -5.878 -10.777 -18.753 1.00 95.31 O \\\\nATOM 2916 N ARG A 368 -5.376 -6.362 -18.767 1.00 94.06 N \\\\nATOM 2917 CA ARG A 368 -4.761 -5.024 -18.728 1.00 94.06 C \\\\nATOM 2918 C ARG A 368 -5.491 -4.059 -17.790 1.00 94.06 C \\\\nATOM 2919 CB ARG A 368 -4.712 -4.429 -20.146 1.00 94.06 C \\\\nATOM 2920 O ARG A 368 -4.845 -3.193 -17.211 1.00 94.06 O \\\\nATOM 2921 CG ARG A 368 -3.878 -5.258 -21.138 1.00 94.06 C \\\\nATOM 2922 CD ARG A 368 -3.914 -4.608 -22.527 1.00 94.06 C \\\\nATOM 2923 NE ARG A 368 -3.118 -5.365 -23.510 1.00 94.06 N \\\\nATOM 2924 NH1 ARG A 368 -3.408 -3.937 -25.296 1.00 94.06 N \\\\nATOM 2925 NH2 ARG A 368 -2.269 -5.831 -25.575 1.00 94.06 N \\\\nATOM 2926 CZ ARG A 368 -2.938 -5.042 -24.782 1.00 94.06 C \\\\nATOM 2927 N MET A 369 -6.806 -4.208 -17.603 1.00 95.92 N \\\\nATOM 2928 CA MET A 369 -7.591 -3.369 -16.685 1.00 95.92 C \\\\nATOM 2929 C MET A 369 -7.190 -3.597 -15.226 1.00 95.92 C \\\\nATOM 2930 CB MET A 369 -9.098 -3.637 -16.840 1.00 95.92 C \\\\nATOM 2931 O MET A 369 -7.254 -2.670 -14.421 1.00 95.92 O \\\\nATOM 2932 CG MET A 369 -9.631 -3.405 -18.258 1.00 95.92 C \\\\nATOM 2933 SD MET A 369 -9.534 -1.698 -18.853 1.00 95.92 S \\\\nATOM 2934 CE MET A 369 -10.858 -0.933 -17.889 1.00 95.92 C \\\\nATOM 2935 N CYS A 370 -6.756 -4.814 -14.892 1.00 97.33 N \\\\nATOM 2936 CA CYS A 370 -6.361 -5.210 -13.542 1.00 97.33 C \\\\nATOM 2937 C CYS A 370 -4.930 -4.783 -13.163 1.00 97.33 C \\\\nATOM 2938 CB CYS A 370 -6.520 -6.726 -13.419 1.00 97.33 C \\\\nATOM 2939 O CYS A 370 -4.534 -4.961 -12.006 1.00 97.33 O \\\\nATOM 2940 SG CYS A 370 -8.188 -7.266 -13.897 1.00 97.33 S \\\\nATOM 2941 N THR A 371 -4.166 -4.227 -14.112 1.00 97.75 N \\\\nATOM 2942 CA THR A 371 -2.799 -3.731 -13.912 1.00 97.75 C \\\\nATOM 2943 C THR A 371 -2.781 -2.203 -13.909 1.00 97.75 C \\\\nATOM 2944 CB THR A 371 -1.831 -4.295 -14.965 1.00 97.75 C \\\\nATOM 2945 O THR A 371 -3.195 -1.556 -14.869 1.00 97.75 O \\\\nATOM 2946 CG2 THR A 371 -0.398 -3.796 -14.784 1.00 97.75 C \\\\nATOM 2947 OG1 THR A 371 -1.781 -5.699 -14.867 1.00 97.75 O \\\\nATOM 2948 N ILE A 372 -2.257 -1.608 -12.836 1.00 98.54 N \\\\nATOM 2949 CA ILE A 372 -2.121 -0.152 -12.686 1.00 98.54 C \\\\nATOM 2950 C ILE A 372 -0.647 0.191 -12.503 1.00 98.54 C \\\\nATOM 2951 CB ILE A 372 -2.996 0.374 -11.525 1.00 98.54 C \\\\nATOM 2952 O ILE A 372 0.026 -0.382 -11.648 1.00 98.54 O \\\\nATOM 2953 CG1 ILE A 372 -4.488 0.075 -11.799 1.00 98.54 C \\\\nATOM 2954 CG2 ILE A 372 -2.745 1.881 -11.307 1.00 98.54 C \\\\nATOM 2955 CD1 ILE A 372 -5.428 0.435 -10.644 1.00 98.54 C \\\\nATOM 2956 N ARG A 373 -0.136 1.158 -13.267 1.00 98.65 N \\\\nATOM 2957 CA ARG A 373 1.268 1.590 -13.178 1.00 98.65 C \\\\nATOM 2958 C ARG A 373 1.374 2.972 -12.567 1.00 98.65 C \\\\nATOM 2959 CB ARG A 373 1.950 1.501 -14.547 1.00 98.65 C \\\\nATOM 2960 O ARG A 373 0.597 3.860 -12.919 1.00 98.65 O \\\\nATOM 2961 CG ARG A 373 1.956 0.049 -15.037 1.00 98.65 C \\\\nATOM 2962 CD ARG A 373 2.780 -0.093 -16.310 1.00 98.65 C \\\\nATOM 2963 NE ARG A 373 2.808 -1.498 -16.728 1.00 98.65 N \\\\nATOM 2964 NH1 ARG A 373 1.773 -1.380 -18.785 1.00 98.65 N \\\\nATOM 2965 NH2 ARG A 373 2.486 -3.339 -17.937 1.00 98.65 N \\\\nATOM 2966 CZ ARG A 373 2.352 -2.053 -17.828 1.00 98.65 C \\\\nATOM 2967 N MET A 374 2.340 3.170 -11.670 1.00 98.70 N \\\\nATOM 2968 CA MET A 374 2.595 4.475 -11.055 1.00 98.70 C \\\\nATOM 2969 C MET A 374 4.073 4.844 -11.050 1.00 98.70 C \\\\nATOM 2970 CB MET A 374 2.054 4.573 -9.625 1.00 98.70 C \\\\nATOM 2971 O MET A 374 4.883 4.113 -10.489 1.00 98.70 O \\\\nATOM 2972 CG MET A 374 0.607 4.118 -9.491 1.00 98.70 C \\\\nATOM 2973 SD MET A 374 -0.088 4.536 -7.879 1.00 98.70 S \\\\nATOM 2974 CE MET A 374 -1.719 3.823 -8.145 1.00 98.70 C \\\\nATOM 2975 N SER A 375 4.416 6.010 -11.595 1.00 98.78 N \\\\nATOM 2976 CA SER A 375 5.757 6.597 -11.498 1.00 98.78 C \\\\nATOM 2977 C SER A 375 5.819 7.646 -10.391 1.00 98.78 C \\\\nATOM 2978 CB SER A 375 6.193 7.202 -12.831 1.00 98.78 C \\\\nATOM 2979 O SER A 375 4.895 8.447 -10.214 1.00 98.78 O \\\\nATOM 2980 OG SER A 375 7.441 7.846 -12.697 1.00 98.78 O \\\\nATOM 2981 N PHE A 376 6.942 7.680 -9.677 1.00 98.81 N \\\\nATOM 2982 CA PHE A 376 7.247 8.703 -8.685 1.00 98.81 C \\\\nATOM 2983 C PHE A 376 8.044 9.849 -9.319 1.00 98.81 C \\\\nATOM 2984 CB PHE A 376 8.019 8.080 -7.515 1.00 98.81 C \\\\nATOM 2985 O PHE A 376 9.028 9.620 -10.023 1.00 98.81 O \\\\nATOM 2986 CG PHE A 376 7.275 6.993 -6.762 1.00 98.81 C \\\\nATOM 2987 CD1 PHE A 376 6.403 7.336 -5.711 1.00 98.81 C \\\\nATOM 2988 CD2 PHE A 376 7.459 5.639 -7.102 1.00 98.81 C \\\\nATOM 2989 CE1 PHE A 376 5.723 6.330 -5.001 1.00 98.81 C \\\\nATOM 2990 CE2 PHE A 376 6.777 4.635 -6.393 1.00 98.81 C \\\\nATOM 2991 CZ PHE A 376 5.910 4.979 -5.342 1.00 98.81 C \\\\nATOM 2992 N VAL A 377 7.682 11.099 -9.004 1.00 98.56 N \\\\nATOM 2993 CA VAL A 377 8.406 12.346 -9.346 1.00 98.56 C \\\\nATOM 2994 C VAL A 377 8.447 12.701 -10.843 1.00 98.56 C \\\\nATOM 2995 CB VAL A 377 9.846 12.335 -8.774 1.00 98.56 C \\\\nATOM 2996 O VAL A 377 8.438 13.885 -11.182 1.00 98.56 O \\\\nATOM 2997 CG1 VAL A 377 10.498 13.724 -8.771 1.00 98.56 C \\\\nATOM 2998 CG2 VAL A 377 9.970 11.778 -7.346 1.00 98.56 C \\\\nATOM 2999 N LYS A 378 8.509 11.725 -11.758 1.00 98.24 N \\\\nATOM 3000 CA LYS A 378 8.670 11.928 -13.209 1.00 98.24 C \\\\nATOM 3001 C LYS A 378 7.483 11.353 -13.989 1.00 98.24 C \\\\nATOM 3002 CB LYS A 378 9.996 11.299 -13.693 1.00 98.24 C \\\\nATOM 3003 O LYS A 378 7.233 10.155 -13.919 1.00 98.24 O \\\\nATOM 3004 CG LYS A 378 11.266 11.754 -12.948 1.00 98.24 C \\\\nATOM 3005 CD LYS A 378 11.501 13.272 -12.973 1.00 98.24 C \\\\nATOM 3006 CE LYS A 378 12.773 13.608 -12.185 1.00 98.24 C \\\\nATOM 3007 NZ LYS A 378 12.933 15.073 -12.002 1.00 98.24 N \\\\nATOM 3008 N GLY A 379 6.803 12.192 -14.767 1.00 97.29 N \\\\nATOM 3009 CA GLY A 379 5.748 11.760 -15.689 1.00 97.29 C \\\\nATOM 3010 C GLY A 379 6.277 11.053 -16.939 1.00 97.29 C \\\\nATOM 3011 O GLY A 379 7.464 11.159 -17.273 1.00 97.29 O \\\\nATOM 3012 N TRP A 380 5.368 10.348 -17.612 1.00 98.27 N \\\\nATOM 3013 CA TRP A 380 5.543 9.736 -18.930 1.00 98.27 C \\\\nATOM 3014 C TRP A 380 4.223 9.790 -19.721 1.00 98.27 C \\\\nATOM 3015 CB TRP A 380 6.049 8.290 -18.793 1.00 98.27 C \\\\nATOM 3016 O TRP A 380 3.188 10.128 -19.148 1.00 98.27 O \\\\nATOM 3017 CG TRP A 380 5.001 7.249 -18.540 1.00 98.27 C \\\\nATOM 3018 CD1 TRP A 380 4.437 6.468 -19.491 1.00 98.27 C \\\\nATOM 3019 CD2 TRP A 380 4.327 6.901 -17.293 1.00 98.27 C \\\\nATOM 3020 CE2 TRP A 380 3.395 5.855 -17.564 1.00 98.27 C \\\\nATOM 3021 CE3 TRP A 380 4.395 7.369 -15.962 1.00 98.27 C \\\\nATOM 3022 NE1 TRP A 380 3.495 5.638 -18.919 1.00 98.27 N \\\\nATOM 3023 CH2 TRP A 380 2.678 5.771 -15.259 1.00 98.27 C \\\\nATOM 3024 CZ2 TRP A 380 2.605 5.271 -16.567 1.00 98.27 C \\\\nATOM 3025 CZ3 TRP A 380 3.563 6.822 -14.967 1.00 98.27 C \\\\nATOM 3026 N GLY A 381 4.259 9.453 -21.010 1.00 95.83 N \\\\nATOM 3027 CA GLY A 381 3.134 9.560 -21.944 1.00 95.83 C \\\\nATOM 3028 C GLY A 381 3.169 10.863 -22.749 1.00 95.83 C \\\\nATOM 3029 O GLY A 381 4.135 11.616 -22.647 1.00 95.83 O \\\\nATOM 3030 N ALA A 382 2.109 11.126 -23.522 1.00 92.96 N \\\\nATOM 3031 CA ALA A 382 2.044 12.198 -24.528 1.00 92.96 C \\\\nATOM 3032 C ALA A 382 2.542 13.575 -24.035 1.00 92.96 C \\\\nATOM 3033 CB ALA A 382 0.592 12.282 -25.020 1.00 92.96 C \\\\nATOM 3034 O ALA A 382 3.350 14.214 -24.702 1.00 92.96 O \\\\nATOM 3035 N GLU A 383 2.152 13.976 -22.821 1.00 91.46 N \\\\nATOM 3036 CA GLU A 383 2.499 15.270 -22.206 1.00 91.46 C \\\\nATOM 3037 C GLU A 383 3.948 15.372 -21.678 1.00 91.46 C \\\\nATOM 3038 CB GLU A 383 1.507 15.559 -21.063 1.00 91.46 C \\\\nATOM 3039 O GLU A 383 4.318 16.347 -21.019 1.00 91.46 O \\\\nATOM 3040 CG GLU A 383 0.031 15.522 -21.482 1.00 91.46 C \\\\nATOM 3041 CD GLU A 383 -0.228 16.402 -22.707 1.00 91.46 C \\\\nATOM 3042 OE1 GLU A 383 -0.810 15.863 -23.671 1.00 91.46 O \\\\nATOM 3043 OE2 GLU A 383 0.203 17.575 -22.659 1.00 91.46 O \\\\nATOM 3044 N TYR A 384 4.787 14.351 -21.888 1.00 95.61 N \\\\nATOM 3045 CA TYR A 384 6.121 14.262 -21.297 1.00 95.61 C \\\\nATOM 3046 C TYR A 384 7.166 13.757 -22.295 1.00 95.61 C \\\\nATOM 3047 CB TYR A 384 6.084 13.357 -20.051 1.00 95.61 C \\\\nATOM 3048 O TYR A 384 6.925 12.880 -23.113 1.00 95.61 O \\\\nATOM 3049 CG TYR A 384 5.120 13.811 -18.968 1.00 95.61 C \\\\nATOM 3050 CD1 TYR A 384 5.477 14.837 -18.069 1.00 95.61 C \\\\nATOM 3051 CD2 TYR A 384 3.824 13.267 -18.924 1.00 95.61 C \\\\nATOM 3052 CE1 TYR A 384 4.523 15.344 -17.162 1.00 95.61 C \\\\nATOM 3053 CE2 TYR A 384 2.872 13.758 -18.015 1.00 95.61 C \\\\nATOM 3054 OH TYR A 384 2.248 15.383 -16.376 1.00 95.61 O \\\\nATOM 3055 CZ TYR A 384 3.208 14.827 -17.161 1.00 95.61 C \\\\nATOM 3056 N ARG A 385 8.418 14.209 -22.132 1.00 95.60 N \\\\nATOM 3057 CA ARG A 385 9.572 13.721 -22.919 1.00 95.60 C \\\\nATOM 3058 C ARG A 385 9.787 12.195 -22.835 1.00 95.60 C \\\\nATOM 3059 CB ARG A 385 10.822 14.516 -22.492 1.00 95.60 C \\\\nATOM 3060 O ARG A 385 10.451 11.618 -23.689 1.00 95.60 O \\\\nATOM 3061 CG ARG A 385 12.085 14.098 -23.262 1.00 95.60 C \\\\nATOM 3062 CD ARG A 385 13.284 15.003 -22.977 1.00 95.60 C \\\\nATOM 3063 NE ARG A 385 14.513 14.388 -23.516 1.00 95.60 N \\\\nATOM 3064 NH1 ARG A 385 15.973 15.009 -21.858 1.00 95.60 N \\\\nATOM 3065 NH2 ARG A 385 16.623 13.531 -23.347 1.00 95.60 N \\\\nATOM 3066 CZ ARG A 385 15.687 14.316 -22.919 1.00 95.60 C \\\\nATOM 3067 N ARG A 386 9.276 11.538 -21.790 1.00 96.56 N \\\\nATOM 3068 CA ARG A 386 9.328 10.080 -21.615 1.00 96.56 C \\\\nATOM 3069 C ARG A 386 8.064 9.473 -22.206 1.00 96.56 C \\\\nATOM 3070 CB ARG A 386 9.416 9.737 -20.120 1.00 96.56 C \\\\nATOM 3071 O ARG A 386 7.011 9.641 -21.612 1.00 96.56 O \\\\nATOM 3072 CG ARG A 386 10.779 10.093 -19.533 1.00 96.56 C \\\\nATOM 3073 CD ARG A 386 10.772 9.857 -18.020 1.00 96.56 C \\\\nATOM 3074 NE ARG A 386 12.126 10.031 -17.471 1.00 96.56 N \\\\nATOM 3075 NH1 ARG A 386 12.152 12.322 -17.440 1.00 96.56 N \\\\nATOM 3076 NH2 ARG A 386 14.040 11.183 -17.055 1.00 96.56 N \\\\nATOM 3077 CZ ARG A 386 12.764 11.175 -17.316 1.00 96.56 C \\\\nATOM 3078 N GLN A 387 8.162 8.731 -23.303 1.00 96.27 N \\\\nATOM 3079 CA GLN A 387 6.978 8.072 -23.868 1.00 96.27 C \\\\nATOM 3080 C GLN A 387 6.599 6.798 -23.101 1.00 96.27 C \\\\nATOM 3081 CB GLN A 387 7.175 7.829 -25.375 1.00 96.27 C \\\\nATOM 3082 O GLN A 387 5.418 6.542 -22.877 1.00 96.27 O \\\\nATOM 3083 CG GLN A 387 7.368 9.140 -26.168 1.00 96.27 C \\\\nATOM 3084 CD GLN A 387 6.268 10.168 -25.894 1.00 96.27 C \\\\nATOM 3085 NE2 GLN A 387 6.591 11.439 -25.828 1.00 96.27 N \\\\nATOM 3086 OE1 GLN A 387 5.116 9.840 -25.663 1.00 96.27 O \\\\nATOM 3087 N THR A 388 7.585 6.039 -22.609 1.00 96.77 N \\\\nATOM 3088 CA THR A 388 7.359 4.769 -21.901 1.00 96.77 C \\\\nATOM 3089 C THR A 388 7.482 4.891 -20.379 1.00 96.77 C \\\\nATOM 3090 CB THR A 388 8.262 3.641 -22.424 1.00 96.77 C \\\\nATOM 3091 O THR A 388 8.281 5.683 -19.868 1.00 96.77 O \\\\nATOM 3092 CG2 THR A 388 8.328 3.568 -23.951 1.00 96.77 C \\\\nATOM 3093 OG1 THR A 388 9.576 3.812 -21.939 1.00 96.77 O \\\\nATOM 3094 N VAL A 389 6.756 4.048 -19.633 1.00 97.45 N \\\\nATOM 3095 CA VAL A 389 6.912 3.957 -18.167 1.00 97.45 C \\\\nATOM 3096 C VAL A 389 8.310 3.454 -17.785 1.00 97.45 C \\\\nATOM 3097 CB VAL A 389 5.801 3.086 -17.550 1.00 97.45 C \\\\nATOM 3098 O VAL A 389 8.912 3.944 -16.831 1.00 97.45 O \\\\nATOM 3099 CG1 VAL A 389 5.955 1.595 -17.873 1.00 97.45 C \\\\nATOM 3100 CG2 VAL A 389 5.724 3.294 -16.035 1.00 97.45 C \\\\nATOM 3101 N THR A 390 8.887 2.575 -18.610 1.00 97.99 N \\\\nATOM 3102 CA THR A 390 10.258 2.053 -18.489 1.00 97.99 C \\\\nATOM 3103 C THR A 390 11.346 3.119 -18.676 1.00 97.99 C \\\\nATOM 3104 CB THR A 390 10.484 0.908 -19.489 1.00 97.99 C \\\\nATOM 3105 O THR A 390 12.499 2.887 -18.328 1.00 97.99 O \\\\nATOM 3106 CG2 THR A 390 9.628 -0.312 -19.156 1.00 97.99 C \\\\nATOM 3107 OG1 THR A 390 10.131 1.299 -20.801 1.00 97.99 O \\\\nATOM 3108 N SER A 391 10.993 4.315 -19.163 1.00 97.57 N \\\\nATOM 3109 CA SER A 391 11.880 5.488 -19.190 1.00 97.57 C \\\\nATOM 3110 C SER A 391 11.865 6.287 -17.876 1.00 97.57 C \\\\nATOM 3111 CB SER A 391 11.491 6.413 -20.347 1.00 97.57 C \\\\nATOM 3112 O SER A 391 12.628 7.250 -17.716 1.00 97.57 O \\\\nATOM 3113 OG SER A 391 11.570 5.771 -21.600 1.00 97.57 O \\\\nATOM 3114 N THR A 392 10.972 5.959 -16.936 1.00 98.21 N \\\\nATOM 3115 CA THR A 392 10.876 6.643 -15.639 1.00 98.21 C \\\\nATOM 3116 C THR A 392 11.872 6.052 -14.631 1.00 98.21 C \\\\nATOM 3117 CB THR A 392 9.458 6.672 -15.051 1.00 98.21 C \\\\nATOM 3118 O THR A 392 12.089 4.840 -14.616 1.00 98.21 O \\\\nATOM 3119 CG2 THR A 392 8.388 7.194 -16.015 1.00 98.21 C \\\\nATOM 3120 OG1 THR A 392 9.084 5.412 -14.573 1.00 98.21 O \\\\nATOM 3121 N PRO A 393 12.518 6.866 -13.771 1.00 98.48 N \\\\nATOM 3122 CA PRO A 393 13.592 6.349 -12.921 1.00 98.48 C \\\\nATOM 3123 C PRO A 393 13.100 5.443 -11.783 1.00 98.48 C \\\\nATOM 3124 CB PRO A 393 14.326 7.582 -12.381 1.00 98.48 C \\\\nATOM 3125 O PRO A 393 13.865 4.617 -11.299 1.00 98.48 O \\\\nATOM 3126 CG PRO A 393 13.897 8.717 -13.306 1.00 98.48 C \\\\nATOM 3127 CD PRO A 393 12.477 8.318 -13.683 1.00 98.48 C \\\\nATOM 3128 N CYS A 394 11.856 5.613 -11.327 1.00 98.74 N \\\\nATOM 3129 CA CYS A 394 11.266 4.879 -10.207 1.00 98.74 C \\\\nATOM 3130 C CYS A 394 9.761 4.723 -10.431 1.00 98.74 C \\\\nATOM 3131 CB CYS A 394 11.484 5.670 -8.905 1.00 98.74 C \\\\nATOM 3132 O CYS A 394 9.036 5.719 -10.370 1.00 98.74 O \\\\nATOM 3133 SG CYS A 394 13.241 5.820 -8.497 1.00 98.74 S \\\\nATOM 3134 N TRP A 395 9.288 3.495 -10.619 1.00 98.82 N \\\\nATOM 3135 CA TRP A 395 7.864 3.208 -10.776 1.00 98.82 C \\\\nATOM 3136 C TRP A 395 7.477 1.861 -10.162 1.00 98.82 C \\\\nATOM 3137 CB TRP A 395 7.465 3.314 -12.257 1.00 98.82 C \\\\nATOM 3138 O TRP A 395 8.329 1.046 -9.813 1.00 98.82 O \\\\nATOM 3139 CG TRP A 395 8.092 2.330 -13.189 1.00 98.82 C \\\\nATOM 3140 CD1 TRP A 395 9.343 2.411 -13.690 1.00 98.82 C \\\\nATOM 3141 CD2 TRP A 395 7.504 1.123 -13.769 1.00 98.82 C \\\\nATOM 3142 CE2 TRP A 395 8.473 0.520 -14.624 1.00 98.82 C \\\\nATOM 3143 CE3 TRP A 395 6.250 0.480 -13.671 1.00 98.82 C \\\\nATOM 3144 NE1 TRP A 395 9.567 1.348 -14.535 1.00 98.82 N \\\\nATOM 3145 CH2 TRP A 395 6.985 -1.301 -15.179 1.00 98.82 C \\\\nATOM 3146 CZ2 TRP A 395 8.237 -0.677 -15.311 1.00 98.82 C \\\\nATOM 3147 CZ3 TRP A 395 5.993 -0.713 -14.374 1.00 98.82 C \\\\nATOM 3148 N ILE A 396 6.178 1.660 -9.978 1.00 98.81 N \\\\nATOM 3149 CA ILE A 396 5.573 0.439 -9.447 1.00 98.81 C \\\\nATOM 3150 C ILE A 396 4.464 -0.057 -10.370 1.00 98.81 C \\\\nATOM 3151 CB ILE A 396 5.055 0.618 -7.998 1.00 98.81 C \\\\nATOM 3152 O ILE A 396 3.745 0.736 -10.983 1.00 98.81 O \\\\nATOM 3153 CG1 ILE A 396 4.207 1.900 -7.835 1.00 98.81 C \\\\nATOM 3154 CG2 ILE A 396 6.250 0.602 -7.030 1.00 98.81 C \\\\nATOM 3155 CD1 ILE A 396 3.470 2.058 -6.498 1.00 98.81 C \\\\nATOM 3156 N GLU A 397 4.315 -1.374 -10.421 1.00 98.72 N \\\\nATOM 3157 CA GLU A 397 3.209 -2.078 -11.062 1.00 98.72 C \\\\nATOM 3158 C GLU A 397 2.344 -2.726 -9.976 1.00 98.72 C \\\\nATOM 3159 CB GLU A 397 3.781 -3.100 -12.056 1.00 98.72 C \\\\nATOM 3160 O GLU A 397 2.847 -3.509 -9.169 1.00 98.72 O \\\\nATOM 3161 CG GLU A 397 2.709 -3.684 -12.983 1.00 98.72 C \\\\nATOM 3162 CD GLU A 397 3.354 -4.370 -14.196 1.00 98.72 C \\\\nATOM 3163 OE1 GLU A 397 4.027 -5.404 -14.009 1.00 98.72 O \\\\nATOM 3164 OE2 GLU A 397 3.229 -3.803 -15.313 1.00 98.72 O \\\\nATOM 3165 N LEU A 398 1.064 -2.356 -9.931 1.00 98.36 N \\\\nATOM 3166 CA LEU A 398 0.030 -2.936 -9.076 1.00 98.36 C \\\\nATOM 3167 C LEU A 398 -0.766 -3.952 -9.890 1.00 98.36 C \\\\nATOM 3168 CB LEU A 398 -0.960 -1.852 -8.600 1.00 98.36 C \\\\nATOM 3169 O LEU A 398 -1.309 -3.596 -10.934 1.00 98.36 O \\\\nATOM 3170 CG LEU A 398 -0.604 -1.058 -7.342 1.00 98.36 C \\\\nATOM 3171 CD1 LEU A 398 0.694 -0.268 -7.468 1.00 98.36 C \\\\nATOM 3172 CD2 LEU A 398 -1.738 -0.065 -7.071 1.00 98.36 C \\\\nATOM 3173 N HIS A 399 -0.933 -5.157 -9.358 1.00 98.32 N \\\\nATOM 3174 CA HIS A 399 -1.912 -6.134 -9.832 1.00 98.32 C \\\\nATOM 3175 C HIS A 399 -3.045 -6.261 -8.817 1.00 98.32 C \\\\nATOM 3176 CB HIS A 399 -1.212 -7.476 -10.077 1.00 98.32 C \\\\nATOM 3177 O HIS A 399 -2.795 -6.535 -7.642 1.00 98.32 O \\\\nATOM 3178 CG HIS A 399 -0.309 -7.495 -11.284 1.00 98.32 C \\\\nATOM 3179 CD2 HIS A 399 -0.246 -6.557 -12.278 1.00 98.32 C \\\\nATOM 3180 ND1 HIS A 399 0.574 -8.494 -11.622 1.00 98.32 N \\\\nATOM 3181 CE1 HIS A 399 1.150 -8.160 -12.792 1.00 98.32 C \\\\nATOM 3182 NE2 HIS A 399 0.669 -6.989 -13.236 1.00 98.32 N \\\\nATOM 3183 N LEU A 400 -4.286 -6.050 -9.260 1.00 98.07 N \\\\nATOM 3184 CA LEU A 400 -5.481 -6.181 -8.426 1.00 98.07 C \\\\nATOM 3185 C LEU A 400 -5.967 -7.633 -8.445 1.00 98.07 C \\\\nATOM 3186 CB LEU A 400 -6.556 -5.184 -8.888 1.00 98.07 C \\\\nATOM 3187 O LEU A 400 -6.554 -8.105 -9.419 1.00 98.07 O \\\\nATOM 3188 CG LEU A 400 -6.121 -3.708 -8.840 1.00 98.07 C \\\\nATOM 3189 CD1 LEU A 400 -7.303 -2.837 -9.244 1.00 98.07 C \\\\nATOM 3190 CD2 LEU A 400 -5.657 -3.258 -7.451 1.00 98.07 C \\\\nATOM 3191 N ASN A 401 -5.706 -8.350 -7.354 1.00 97.27 N \\\\nATOM 3192 CA ASN A 401 -5.823 -9.807 -7.309 1.00 97.27 C \\\\nATOM 3193 C ASN A 401 -7.278 -10.291 -7.399 1.00 97.27 C \\\\nATOM 3194 CB ASN A 401 -5.159 -10.310 -6.019 1.00 97.27 C \\\\nATOM 3195 O ASN A 401 -7.529 -11.344 -7.975 1.00 97.27 O \\\\nATOM 3196 CG ASN A 401 -3.660 -10.068 -5.942 1.00 97.27 C \\\\nATOM 3197 ND2 ASN A 401 -3.127 -10.033 -4.747 1.00 97.27 N \\\\nATOM 3198 OD1 ASN A 401 -2.948 -9.899 -6.917 1.00 97.27 O \\\\nATOM 3199 N GLY A 402 -8.237 -9.532 -6.858 1.00 95.66 N \\\\nATOM 3200 CA GLY A 402 -9.663 -9.875 -6.913 1.00 95.66 C \\\\nATOM 3201 C GLY A 402 -10.217 -9.810 -8.341 1.00 95.66 C \\\\nATOM 3202 O GLY A 402 -10.705 -10.824 -8.843 1.00 95.66 O \\\\nATOM 3203 N PRO A 403 -10.083 -8.665 -9.040 1.00 96.62 N \\\\nATOM 3204 CA PRO A 403 -10.371 -8.549 -10.469 1.00 96.62 C \\\\nATOM 3205 C PRO A 403 -9.676 -9.615 -11.333 1.00 96.62 C \\\\nATOM 3206 CB PRO A 403 -9.945 -7.123 -10.839 1.00 96.62 C \\\\nATOM 3207 O PRO A 403 -10.339 -10.236 -12.160 1.00 96.62 O \\\\nATOM 3208 CG PRO A 403 -10.232 -6.348 -9.555 1.00 96.62 C \\\\nATOM 3209 CD PRO A 403 -9.818 -7.347 -8.476 1.00 96.62 C \\\\nATOM 3210 N LEU A 404 -8.385 -9.904 -11.099 1.00 96.80 N \\\\nATOM 3211 CA LEU A 404 -7.666 -10.983 -11.798 1.00 96.80 C \\\\nATOM 3212 C LEU A 404 -8.263 -12.371 -11.528 1.00 96.80 C \\\\nATOM 3213 CB LEU A 404 -6.174 -10.983 -11.410 1.00 96.80 C \\\\nATOM 3214 O LEU A 404 -8.483 -13.127 -12.468 1.00 96.80 O \\\\nATOM 3215 CG LEU A 404 -5.348 -9.857 -12.047 1.00 96.80 C \\\\nATOM 3216 CD1 LEU A 404 -3.952 -9.816 -11.431 1.00 96.80 C \\\\nATOM 3217 CD2 LEU A 404 -5.193 -10.022 -13.561 1.00 96.80 C \\\\nATOM 3218 N GLN A 405 -8.560 -12.711 -10.271 1.00 94.96 N \\\\nATOM 3219 CA GLN A 405 -9.154 -14.005 -9.921 1.00 94.96 C \\\\nATOM 3220 C GLN A 405 -10.559 -14.168 -10.515 1.00 94.96 C \\\\nATOM 3221 CB GLN A 405 -9.194 -14.155 -8.390 1.00 94.96 C \\\\nATOM 3222 O GLN A 405 -10.961 -15.273 -10.878 1.00 94.96 O \\\\nATOM 3223 CG GLN A 405 -9.640 -15.569 -7.985 1.00 94.96 C \\\\nATOM 3224 CD GLN A 405 -9.740 -15.779 -6.480 1.00 94.96 C \\\\nATOM 3225 NE2 GLN A 405 -9.435 -16.962 -5.997 1.00 94.96 N \\\\nATOM 3226 OE1 GLN A 405 -10.159 -14.935 -5.711 1.00 94.96 O \\\\nATOM 3227 N TRP A 406 -11.330 -13.084 -10.611 1.00 94.76 N \\\\nATOM 3228 CA TRP A 406 -12.641 -13.131 -11.250 1.00 94.76 C \\\\nATOM 3229 C TRP A 406 -12.522 -13.339 -12.760 1.00 94.76 C \\\\nATOM 3230 CB TRP A 406 -13.421 -11.861 -10.921 1.00 94.76 C \\\\nATOM 3231 O TRP A 406 -13.245 -14.162 -13.318 1.00 94.76 O \\\\nATOM 3232 CG TRP A 406 -14.901 -11.926 -11.139 1.00 94.76 C \\\\nATOM 3233 CD1 TRP A 406 -15.639 -13.020 -11.452 1.00 94.76 C \\\\nATOM 3234 CD2 TRP A 406 -15.853 -10.833 -11.027 1.00 94.76 C \\\\nATOM 3235 CE2 TRP A 406 -17.167 -11.362 -11.172 1.00 94.76 C \\\\nATOM 3236 CE3 TRP A 406 -15.734 -9.448 -10.788 1.00 94.76 C \\\\nATOM 3237 NE1 TRP A 406 -16.980 -12.692 -11.466 1.00 94.76 N \\\\nATOM 3238 CH2 TRP A 406 -18.161 -9.205 -10.753 1.00 94.76 C \\\\nATOM 3239 CZ2 TRP A 406 -18.308 -10.573 -11.020 1.00 94.76 C \\\\nATOM 3240 CZ3 TRP A 406 -16.875 -8.643 -10.643 1.00 94.76 C \\\\nATOM 3241 N LEU A 407 -11.569 -12.651 -13.393 1.00 95.07 N \\\\nATOM 3242 CA LEU A 407 -11.270 -12.788 -14.812 1.00 95.07 C \\\\nATOM 3243 C LEU A 407 -10.824 -14.213 -15.175 1.00 95.07 C \\\\nATOM 3244 CB LEU A 407 -10.192 -11.749 -15.164 1.00 95.07 C \\\\nATOM 3245 O LEU A 407 -11.353 -14.798 -16.115 1.00 95.07 O \\\\nATOM 3246 CG LEU A 407 -9.929 -11.642 -16.669 1.00 95.07 C \\\\nATOM 3247 CD1 LEU A 407 -11.149 -11.068 -17.375 1.00 95.07 C \\\\nATOM 3248 CD2 LEU A 407 -8.748 -10.715 -16.923 1.00 95.07 C \\\\nATOM 3249 N ASP A 408 -9.917 -14.797 -14.390 1.00 93.11 N \\\\nATOM 3250 CA ASP A 408 -9.437 -16.178 -14.539 1.00 93.11 C \\\\nATOM 3251 C ASP A 408 -10.587 -17.204 -14.477 1.00 93.11 C \\\\nATOM 3252 CB ASP A 408 -8.399 -16.419 -13.435 1.00 93.11 C \\\\nATOM 3253 O ASP A 408 -10.728 -18.059 -15.355 1.00 93.11 O \\\\nATOM 3254 CG ASP A 408 -7.860 -17.847 -13.445 1.00 93.11 C \\\\nATOM 3255 OD1 ASP A 408 -7.091 -18.163 -14.378 1.00 93.11 O \\\\nATOM 3256 OD2 ASP A 408 -8.220 -18.594 -12.507 1.00 93.11 O \\\\nATOM 3257 N LYS A 409 -11.502 -17.057 -13.508 1.00 92.52 N \\\\nATOM 3258 CA LYS A 409 -12.709 -17.897 -13.397 1.00 92.52 C \\\\nATOM 3259 C LYS A 409 -13.689 -17.758 -14.570 1.00 92.52 C \\\\nATOM 3260 CB LYS A 409 -13.466 -17.549 -12.121 1.00 92.52 C \\\\nATOM 3261 O LYS A 409 -14.478 -18.674 -14.795 1.00 92.52 O \\\\nATOM 3262 CG LYS A 409 -12.815 -18.012 -10.816 1.00 92.52 C \\\\nATOM 3263 CD LYS A 409 -13.636 -17.364 -9.697 1.00 92.52 C \\\\nATOM 3264 CE LYS A 409 -13.255 -17.844 -8.303 1.00 92.52 C \\\\nATOM 3265 NZ LYS A 409 -14.099 -17.132 -7.314 1.00 92.52 N \\\\nATOM 3266 N VAL A 410 -13.695 -16.619 -15.268 1.00 92.90 N \\\\nATOM 3267 CA VAL A 410 -14.493 -16.418 -16.489 1.00 92.90 C \\\\nATOM 3268 C VAL A 410 -13.777 -17.046 -17.685 1.00 92.90 C \\\\nATOM 3269 CB VAL A 410 -14.818 -14.925 -16.709 1.00 92.90 C \\\\nATOM 3270 O VAL A 410 -14.371 -17.866 -18.380 1.00 92.90 O \\\\nATOM 3271 CG1 VAL A 410 -15.438 -14.649 -18.082 1.00 92.90 C \\\\nATOM 3272 CG2 VAL A 410 -15.821 -14.432 -15.656 1.00 92.90 C \\\\nATOM 3273 N LEU A 411 -12.490 -16.743 -17.889 1.00 91.89 N \\\\nATOM 3274 CA LEU A 411 -11.679 -17.284 -18.988 1.00 91.89 C \\\\nATOM 3275 C LEU A 411 -11.652 -18.818 -18.994 1.00 91.89 C \\\\nATOM 3276 CB LEU A 411 -10.248 -16.723 -18.887 1.00 91.89 C \\\\nATOM 3277 O LEU A 411 -11.850 -19.428 -20.042 1.00 91.89 O \\\\nATOM 3278 CG LEU A 411 -10.117 -15.253 -19.320 1.00 91.89 C \\\\nATOM 3279 CD1 LEU A 411 -8.733 -14.724 -18.945 1.00 91.89 C \\\\nATOM 3280 CD2 LEU A 411 -10.290 -15.094 -20.834 1.00 91.89 C \\\\nATOM 3281 N THR A 412 -11.507 -19.444 -17.823 1.00 89.09 N \\\\nATOM 3282 CA THR A 412 -11.554 -20.911 -17.663 1.00 89.09 C \\\\nATOM 3283 C THR A 412 -12.888 -21.550 -18.070 1.00 89.09 C \\\\nATOM 3284 CB THR A 412 -11.218 -21.336 -16.222 1.00 89.09 C \\\\nATOM 3285 O THR A 412 -12.927 -22.757 -18.300 1.00 89.09 O \\\\nATOM 3286 CG2 THR A 412 -9.732 -21.190 -15.906 1.00 89.09 C \\\\nATOM 3287 OG1 THR A 412 -11.912 -20.558 -15.277 1.00 89.09 O \\\\nATOM 3288 N GLN A 413 -13.972 -20.775 -18.201 1.00 86.81 N \\\\nATOM 3289 CA GLN A 413 -15.280 -21.252 -18.672 1.00 86.81 C \\\\nATOM 3290 C GLN A 413 -15.551 -20.940 -20.153 1.00 86.81 C \\\\nATOM 3291 CB GLN A 413 -16.392 -20.705 -17.761 1.00 86.81 C \\\\nATOM 3292 O GLN A 413 -16.411 -21.583 -20.748 1.00 86.81 O \\\\nATOM 3293 CG GLN A 413 -16.258 -21.285 -16.347 1.00 86.81 C \\\\nATOM 3294 CD GLN A 413 -17.349 -20.835 -15.387 1.00 86.81 C \\\\nATOM 3295 NE2 GLN A 413 -17.067 -20.833 -14.103 1.00 86.81 N \\\\nATOM 3296 OE1 GLN A 413 -18.474 -20.520 -15.728 1.00 86.81 O \\\\nATOM 3297 N MET A 414 -14.802 -20.018 -20.773 1.00 85.54 N \\\\nATOM 3298 CA MET A 414 -14.980 -19.637 -22.185 1.00 85.54 C \\\\nATOM 3299 C MET A 414 -14.133 -20.455 -23.177 1.00 85.54 C \\\\nATOM 3300 CB MET A 414 -14.761 -18.132 -22.380 1.00 85.54 C \\\\nATOM 3301 O MET A 414 -14.115 -20.160 -24.369 1.00 85.54 O \\\\nATOM 3302 CG MET A 414 -15.737 -17.300 -21.541 1.00 85.54 C \\\\nATOM 3303 SD MET A 414 -15.963 -15.552 -21.980 1.00 85.54 S \\\\nATOM 3304 CE MET A 414 -14.405 -15.179 -22.806 1.00 85.54 C \\\\nATOM 3305 N GLY A 415 -13.432 -21.496 -22.723 1.00 82.14 N \\\\nATOM 3306 CA GLY A 415 -12.658 -22.373 -23.604 1.00 82.14 C \\\\nATOM 3307 C GLY A 415 -11.343 -21.744 -24.076 1.00 82.14 C \\\\nATOM 3308 O GLY A 415 -10.474 -21.450 -23.260 1.00 82.14 O \\\\nATOM 3309 N SER A 416 -11.159 -21.607 -25.392 1.00 81.44 N \\\\nATOM 3310 CA SER A 416 -9.897 -21.178 -26.015 1.00 81.44 C \\\\nATOM 3311 C SER A 416 -10.125 -20.213 -27.186 1.00 81.44 C \\\\nATOM 3312 CB SER A 416 -9.114 -22.408 -26.502 1.00 81.44 C \\\\nATOM 3313 O SER A 416 -11.213 -20.226 -27.766 1.00 81.44 O \\\\nATOM 3314 OG SER A 416 -9.784 -23.090 -27.551 1.00 81.44 O \\\\nATOM 3315 N PRO A 417 -9.103 -19.446 -27.618 1.00 82.09 N \\\\nATOM 3316 CA PRO A 417 -9.158 -18.678 -28.861 1.00 82.09 C \\\\nATOM 3317 C PRO A 417 -9.571 -19.530 -30.072 1.00 82.09 C \\\\nATOM 3318 CB PRO A 417 -7.753 -18.096 -29.059 1.00 82.09 C \\\\nATOM 3319 O PRO A 417 -9.239 -20.715 -30.158 1.00 82.09 O \\\\nATOM 3320 CG PRO A 417 -7.186 -18.034 -27.644 1.00 82.09 C \\\\nATOM 3321 CD PRO A 417 -7.814 -19.252 -26.967 1.00 82.09 C \\\\nATOM 3322 N SER A 418 -10.262 -18.910 -31.031 1.00 80.99 N \\\\nATOM 3323 CA SER A 418 -10.662 -19.545 -32.296 1.00 80.99 C \\\\nATOM 3324 C SER A 418 -9.466 -19.816 -33.218 1.00 80.99 C \\\\nATOM 3325 CB SER A 418 -11.680 -18.649 -33.011 1.00 80.99 C \\\\nATOM 3326 O SER A 418 -9.413 -20.846 -33.893 1.00 80.99 O \\\\nATOM 3327 OG SER A 418 -11.172 -17.331 -33.132 1.00 80.99 O \\\\nATOM 3328 N ILE A 419 -8.483 -18.912 -33.221 1.00 81.26 N \\\\nATOM 3329 CA ILE A 419 -7.231 -19.055 -33.965 1.00 81.26 C \\\\nATOM 3330 C ILE A 419 -6.295 -19.973 -33.174 1.00 81.26 C \\\\nATOM 3331 CB ILE A 419 -6.594 -17.676 -34.263 1.00 81.26 C \\\\nATOM 3332 O ILE A 419 -5.882 -19.659 -32.058 1.00 81.26 O \\\\nATOM 3333 CG1 ILE A 419 -7.578 -16.783 -35.058 1.00 81.26 C \\\\nATOM 3334 CG2 ILE A 419 -5.278 -17.863 -35.045 1.00 81.26 C \\\\nATOM 3335 CD1 ILE A 419 -7.081 -15.352 -35.301 1.00 81.26 C \\\\nATOM 3336 N ARG A 420 -5.929 -21.114 -33.767 1.00 83.97 N \\\\nATOM 3337 CA ARG A 420 -4.920 -22.014 -33.193 1.00 83.97 C \\\\nATOM 3338 C ARG A 420 -3.526 -21.423 -33.385 1.00 83.97 C \\\\nATOM 3339 CB ARG A 420 -5.003 -23.414 -33.814 1.00 83.97 C \\\\nATOM 3340 O ARG A 420 -3.164 -21.055 -34.499 1.00 83.97 O \\\\nATOM 3341 CG ARG A 420 -6.335 -24.106 -33.502 1.00 83.97 C \\\\nATOM 3342 CD ARG A 420 -6.312 -25.543 -34.028 1.00 83.97 C \\\\nATOM 3343 NE ARG A 420 -7.597 -26.219 -33.779 1.00 83.97 N \\\\nATOM 3344 NH1 ARG A 420 -6.954 -28.339 -34.384 1.00 83.97 N \\\\nATOM 3345 NH2 ARG A 420 -9.053 -27.965 -33.716 1.00 83.97 N \\\\nATOM 3346 CZ ARG A 420 -7.860 -27.500 -33.960 1.00 83.97 C \\\\nATOM 3347 N CYS A 421 -2.733 -21.398 -32.318 1.00 83.68 N \\\\nATOM 3348 CA CYS A 421 -1.320 -21.044 -32.406 1.00 83.68 C \\\\nATOM 3349 C CYS A 421 -0.531 -22.142 -33.143 1.00 83.68 C \\\\nATOM 3350 CB CYS A 421 -0.786 -20.779 -30.993 1.00 83.68 C \\\\nATOM 3351 O CYS A 421 -0.792 -23.334 -32.955 1.00 83.68 O \\\\nATOM 3352 SG CYS A 421 0.817 -19.947 -31.129 1.00 83.68 S \\\\nATOM 3353 N SER A 422 0.433 -21.746 -33.976 1.00 85.93 N \\\\nATOM 3354 CA SER A 422 1.379 -22.670 -34.607 1.00 85.93 C \\\\nATOM 3355 C SER A 422 2.461 -23.078 -33.607 1.00 85.93 C \\\\nATOM 3356 CB SER A 422 2.006 -22.014 -35.839 1.00 85.93 C \\\\nATOM 3357 O SER A 422 2.934 -22.264 -32.823 1.00 85.93 O \\\\nATOM 3358 OG SER A 422 3.003 -22.843 -36.411 1.00 85.93 O \\\\nATOM 3359 N SER A 423 2.904 -24.335 -33.658 1.00 89.58 N \\\\nATOM 3360 CA SER A 423 4.051 -24.816 -32.874 1.00 89.58 C \\\\nATOM 3361 C SER A 423 5.402 -24.609 -33.580 1.00 89.58 C \\\\nATOM 3362 CB SER A 423 3.834 -26.286 -32.505 1.00 89.58 C \\\\nATOM 3363 O SER A 423 6.389 -25.223 -33.179 1.00 89.58 O \\\\nATOM 3364 OG SER A 423 3.847 -27.096 -33.667 1.00 89.58 O \\\\nATOM 3365 N VAL A 424 5.430 -23.853 -34.686 1.00 86.04 N \\\\nATOM 3366 CA VAL A 424 6.582 -23.732 -35.608 1.00 86.04 C \\\\nATOM 3367 C VAL A 424 6.860 -22.279 -36.040 1.00 86.04 C \\\\nATOM 3368 CB VAL A 424 6.367 -24.626 -36.861 1.00 86.04 C \\\\nATOM 3369 O VAL A 424 7.895 -22.021 -36.645 1.00 86.04 O \\\\nATOM 3370 CG1 VAL A 424 7.640 -24.833 -37.700 1.00 86.04 C \\\\nATOM 3371 CG2 VAL A 424 5.872 -26.041 -36.507 1.00 86.04 C \\\\nATOM 3372 N SER A 425 5.935 -21.348 -35.773 1.00 67.52 N \\\\nATOM 3373 CA SER A 425 6.045 -19.920 -36.132 1.00 67.52 C \\\\nATOM 3374 C SER A 425 7.004 -19.152 -35.232 1.00 67.52 C \\\\nATOM 3375 CB SER A 425 4.678 -19.249 -36.048 1.00 67.52 C \\\\nATOM 3376 O SER A 425 6.854 -19.333 -34.002 1.00 67.52 O \\\\nATOM 3377 OG SER A 425 4.186 -19.498 -34.749 1.00 67.52 O \\\\nATOM 3378 OXT SER A 425 7.754 -18.328 -35.788 1.00 67.52 O \\\\nTER 3379 SER A 425 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 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'SER251', 252: 'GLN252', 253: 'PRO253', 254: 'SER254', 255: 'MET255', 256: 'THR256', 257: 'VAL257', 258: 'ASP258', 259: 'GLY259', 260: 'PHE260', 261: 'THR261', 262: 'ASP262', 263: 'PRO263', 264: 'SER264', 265: 'ASN265', 266: 'SER266', 267: 'GLU267', 268: 'ARG268', 269: 'PHE269', 270: 'CYS270', 271: 'LEU271', 272: 'GLY272', 273: 'LEU273', 274: 'LEU274', 275: 'SER275', 276: 'ASN276', 277: 'VAL277', 278: 'ASN278', 279: 'ARG279', 280: 'ASN280', 281: 'ALA281', 282: 'ALA282', 283: 'VAL283', 284: 'GLU284', 285: 'LEU285', 286: 'THR286', 287: 'ARG287', 288: 'ARG288', 289: 'HIS289', 290: 'ILE290', 291: 'GLY291', 292: 'ARG292', 293: 'GLY293', 294: 'VAL294', 295: 'ARG295', 296: 'LEU296', 297: 'TYR297', 298: 'TYR298', 299: 'ILE299', 300: 'GLY300', 301: 'GLY301', 302: 'GLU302', 303: 'VAL303', 304: 'PHE304', 305: 'ALA305', 306: 'GLU306', 307: 'CYS307', 308: 'LEU308', 309: 'SER309', 310: 'ASP310', 311: 'SER311', 312: 'ALA312', 313: 'ILE313', 314: 'PHE314', 315: 'VAL315', 316: 'GLN316', 317: 'SER317', 318: 'PRO318', 319: 'ASN319', 320: 'CYS320', 321: 'ASN321', 322: 'GLN322', 323: 'ARG323', 324: 'TYR324', 325: 'GLY325', 326: 'TRP326', 327: 'HIS327', 328: 'PRO328', 329: 'ALA329', 330: 'THR330', 331: 'VAL331', 332: 'CYS332', 333: 'LYS333', 334: 'ILE334', 335: 'PRO335', 336: 'PRO336', 337: 'GLY337', 338: 'CYS338', 339: 'ASN339', 340: 'LEU340', 341: 'LYS341', 342: 'ILE342', 343: 'PHE343', 344: 'ASN344', 345: 'ASN345', 346: 'GLN346', 347: 'GLU347', 348: 'PHE348', 349: 'ALA349', 350: 'ALA350', 351: 'LEU351', 352: 'LEU352', 353: 'ALA353', 354: 'GLN354', 355: 'SER355', 356: 'VAL356', 357: 'ASN357', 358: 'GLN358', 359: 'GLY359', 360: 'PHE360', 361: 'GLU361', 362: 'ALA362', 363: 'VAL363', 364: 'TYR364', 365: 'GLN365', 366: 'LEU366', 367: 'THR367', 368: 'ARG368', 369: 'MET369', 370: 'CYS370', 371: 'THR371', 372: 'ILE372', 373: 'ARG373', 374: 'MET374', 375: 'SER375', 376: 'PHE376', 377: 'VAL377', 378: 'LYS378', 379: 'GLY379', 380: 'TRP380', 381: 'GLY381', 382: 'ALA382', 383: 'GLU383', 384: 'TYR384', 385: 'ARG385', 386: 'ARG386', 387: 'GLN387', 388: 'THR388', 389: 'VAL389', 390: 'THR390', 391: 'SER391', 392: 'THR392', 393: 'PRO393', 394: 'CYS394', 395: 'TRP395', 396: 'ILE396', 397: 'GLU397', 398: 'LEU398', 399: 'HIS399', 400: 'LEU400', 401: 'ASN401', 402: 'GLY402', 403: 'PRO403', 404: 'LEU404', 405: 'GLN405', 406: 'TRP406', 407: 'LEU407', 408: 'ASP408', 409: 'LYS409', 410: 'VAL410', 411: 'LEU411', 412: 'THR412', 413: 'GLN413', 414: 'MET414', 415: 'GLY415', 416: 'SER416', 417: 'PRO417', 418: 'SER418', 419: 'ILE419', 420: 'ARG420', 421: 'CYS421', 422: 'SER422', 423: 'SER423', 424: 'VAL424', 425: 'SER425'}}}}\\n[TOOL RUN] → drug_central\\n[Drug Central] No drug inputs provided. @ 2025-12-24 19:13:25.721547\\n*NAME* MSigDB\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': ['SMAD2', 'SMAD3'], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id=None, ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=[], functions=[], diseases=[], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={}, nonhuman_interactions={}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={}, avg_exons_per_transcript=None, transcript_count=None, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'], tools_run=['EntityExtraction']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id=None, ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=[], functions=[], diseases=[], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={}, nonhuman_interactions={}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={}, avg_exons_per_transcript=None, transcript_count=None, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.'], tools_run=['EntityExtraction'])}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 0, 'used_tools': ['prot', 'chembl', 'drug_central'], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID'], 'ui': {}, 'prot_html': '\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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    \\\\n\\\\n\\\\n', 'drug_central_html': '', 'aa_seq_html': '', 'text_notes': [], 'drug_targets': {}, 'prot_data_all': {'SMAD2': {'plddt': [{'residue_no': 1, 'score': 0.4065}, {'residue_no': 2, 'score': 0.4007}, {'residue_no': 3, 'score': 0.41960000000000003}, {'residue_no': 4, 'score': 0.49090000000000006}, {'residue_no': 5, 'score': 0.5435}, {'residue_no': 6, 'score': 0.6096}, {'residue_no': 7, 'score': 0.7011}, {'residue_no': 8, 'score': 0.7465999999999999}, {'residue_no': 9, 'score': 0.8138}, {'residue_no': 10, 'score': 0.8804000000000001}, {'residue_no': 11, 'score': 0.8917}, {'residue_no': 12, 'score': 0.9018}, {'residue_no': 13, 'score': 0.9009}, {'residue_no': 14, 'score': 0.9111}, {'residue_no': 15, 'score': 0.9251999999999999}, {'residue_no': 16, 'score': 0.9158}, {'residue_no': 17, 'score': 0.9057999999999999}, {'residue_no': 18, 'score': 0.9139}, {'residue_no': 19, 'score': 0.9172}, {'residue_no': 20, 'score': 0.8942}, {'residue_no': 21, 'score': 0.7673000000000001}, {'residue_no': 22, 'score': 0.6494}, {'residue_no': 23, 'score': 0.4874}, {'residue_no': 24, 'score': 0.3925}, {'residue_no': 25, 'score': 0.3312}, {'residue_no': 26, 'score': 0.2812}, {'residue_no': 27, 'score': 0.3196}, {'residue_no': 28, 'score': 0.3583}, {'residue_no': 29, 'score': 0.3937}, {'residue_no': 30, 'score': 0.3993}, {'residue_no': 31, 'score': 0.4215}, {'residue_no': 32, 'score': 0.5118}, {'residue_no': 33, 'score': 0.5672}, {'residue_no': 34, 'score': 0.6729}, {'residue_no': 35, 'score': 0.7696999999999999}, {'residue_no': 36, 'score': 0.8076000000000001}, {'residue_no': 37, 'score': 0.8337}, {'residue_no': 38, 'score': 0.8565999999999999}, {'residue_no': 39, 'score': 0.8654999999999999}, {'residue_no': 40, 'score': 0.8825}, {'residue_no': 41, 'score': 0.9026000000000001}, {'residue_no': 42, 'score': 0.9051}, {'residue_no': 43, 'score': 0.8989}, {'residue_no': 44, 'score': 0.909}, {'residue_no': 45, 'score': 0.9312999999999999}, {'residue_no': 46, 'score': 0.9075}, {'residue_no': 47, 'score': 0.8931}, {'residue_no': 48, 'score': 0.9211}, {'residue_no': 49, 'score': 0.9283}, {'residue_no': 50, 'score': 0.8933}, {'residue_no': 51, 'score': 0.8870999999999999}, {'residue_no': 52, 'score': 0.9201999999999999}, {'residue_no': 53, 'score': 0.9020999999999999}, {'residue_no': 54, 'score': 0.8628}, {'residue_no': 55, 'score': 0.8595999999999999}, {'residue_no': 56, 'score': 0.8870999999999999}, {'residue_no': 57, 'score': 0.8965000000000001}, {'residue_no': 58, 'score': 0.9208}, {'residue_no': 59, 'score': 0.9216}, {'residue_no': 60, 'score': 0.9246}, {'residue_no': 61, 'score': 0.9387000000000001}, {'residue_no': 62, 'score': 0.9354}, {'residue_no': 63, 'score': 0.9328}, {'residue_no': 64, 'score': 0.9351999999999999}, {'residue_no': 65, 'score': 0.9303}, {'residue_no': 66, 'score': 0.9259999999999999}, {'residue_no': 67, 'score': 0.9264}, {'residue_no': 68, 'score': 0.9197}, {'residue_no': 69, 'score': 0.8965000000000001}, {'residue_no': 70, 'score': 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'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 2 (Q15796) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 467 UNP Q15796 SMAD2_HUMAN 1 467 \\\\nSEQRES 1 A 467 MET SER SER ILE LEU PRO PHE THR PRO PRO VAL VAL LYS \\\\nSEQRES 2 A 467 ARG LEU LEU GLY TRP LYS LYS SER ALA GLY GLY SER GLY \\\\nSEQRES 3 A 467 GLY ALA GLY GLY GLY GLU GLN ASN GLY GLN GLU GLU LYS \\\\nSEQRES 4 A 467 TRP CYS GLU LYS ALA VAL LYS SER LEU VAL LYS LYS LEU \\\\nSEQRES 5 A 467 LYS LYS THR GLY ARG LEU ASP GLU LEU GLU LYS ALA ILE \\\\nSEQRES 6 A 467 THR THR GLN ASN CYS ASN THR LYS CYS VAL THR ILE PRO \\\\nSEQRES 7 A 467 SER THR CYS SER GLU ILE TRP GLY LEU SER THR PRO ASN \\\\nSEQRES 8 A 467 THR ILE ASP GLN TRP ASP THR THR GLY LEU TYR SER PHE \\\\nSEQRES 9 A 467 SER GLU GLN THR ARG SER LEU ASP GLY ARG LEU GLN VAL \\\\nSEQRES 10 A 467 SER HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG \\\\nSEQRES 11 A 467 LEU TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU \\\\nSEQRES 12 A 467 LYS ALA ILE GLU ASN CYS GLU TYR ALA PHE ASN LEU LYS \\\\nSEQRES 13 A 467 LYS ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG \\\\nSEQRES 14 A 467 VAL GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG \\\\nSEQRES 15 A 467 HIS THR GLU ILE LEU THR GLU LEU PRO PRO LEU ASP ASP \\\\nSEQRES 16 A 467 TYR THR HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA \\\\nSEQRES 17 A 467 GLY ILE GLU PRO GLN SER ASN TYR ILE PRO GLU THR PRO \\\\nSEQRES 18 A 467 PRO PRO GLY TYR ILE SER GLU ASP GLY GLU THR SER ASP \\\\nSEQRES 19 A 467 GLN GLN LEU ASN GLN SER MET ASP THR GLY SER PRO ALA \\\\nSEQRES 20 A 467 GLU LEU SER PRO THR THR LEU SER PRO VAL ASN HIS SER \\\\nSEQRES 21 A 467 LEU ASP LEU GLN PRO VAL THR TYR SER GLU PRO ALA PHE \\\\nSEQRES 22 A 467 TRP CYS SER ILE ALA TYR TYR GLU LEU ASN GLN ARG VAL \\\\nSEQRES 23 A 467 GLY GLU THR PHE HIS ALA SER GLN PRO SER LEU THR VAL \\\\nSEQRES 24 A 467 ASP GLY PHE THR ASP PRO SER ASN SER GLU ARG PHE CYS \\\\nSEQRES 25 A 467 LEU GLY LEU LEU SER ASN VAL ASN ARG ASN ALA THR VAL \\\\nSEQRES 26 A 467 GLU MET THR ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU \\\\nSEQRES 27 A 467 TYR TYR ILE GLY GLY GLU VAL PHE ALA GLU CYS LEU SER \\\\nSEQRES 28 A 467 ASP SER ALA ILE PHE VAL GLN SER PRO ASN CYS ASN GLN \\\\nSEQRES 29 A 467 ARG TYR GLY TRP HIS PRO ALA THR VAL CYS LYS ILE PRO \\\\nSEQRES 30 A 467 PRO GLY CYS ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE \\\\nSEQRES 31 A 467 ALA ALA LEU LEU ALA GLN SER VAL ASN GLN GLY PHE GLU \\\\nSEQRES 32 A 467 ALA VAL TYR GLN LEU THR ARG MET CYS THR ILE ARG MET \\\\nSEQRES 33 A 467 SER PHE VAL LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN \\\\nSEQRES 34 A 467 THR VAL THR SER THR PRO CYS TRP ILE GLU LEU HIS LEU \\\\nSEQRES 35 A 467 ASN GLY PRO LEU GLN TRP LEU ASP LYS VAL LEU THR GLN \\\\nSEQRES 36 A 467 MET GLY SER PRO SER VAL ARG CYS SER SER MET SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 -24.572 -42.101 26.586 1.00 40.65 N \\\\nATOM 2 CA MET A 1 -23.660 -40.986 26.918 1.00 40.65 C \\\\nATOM 3 C MET A 1 -24.312 -39.697 26.444 1.00 40.65 C \\\\nATOM 4 CB MET A 1 -22.280 -41.179 26.264 1.00 40.65 C \\\\nATOM 5 O MET A 1 -24.227 -39.375 25.268 1.00 40.65 O \\\\nATOM 6 CG MET A 1 -21.477 -42.313 26.910 1.00 40.65 C \\\\nATOM 7 SD MET A 1 -19.880 -42.579 26.105 1.00 40.65 S \\\\nATOM 8 CE MET A 1 -19.199 -43.908 27.135 1.00 40.65 C \\\\nATOM 9 N SER A 2 -25.061 -39.026 27.318 1.00 40.07 N \\\\nATOM 10 CA SER A 2 -25.762 -37.787 26.974 1.00 40.07 C \\\\nATOM 11 C SER A 2 -24.744 -36.657 26.853 1.00 40.07 C \\\\nATOM 12 CB SER A 2 -26.833 -37.463 28.023 1.00 40.07 C \\\\nATOM 13 O SER A 2 -24.164 -36.225 27.847 1.00 40.07 O \\\\nATOM 14 OG SER A 2 -27.659 -38.600 28.207 1.00 40.07 O \\\\nATOM 15 N SER A 3 -24.488 -36.213 25.627 1.00 41.96 N \\\\nATOM 16 CA SER A 3 -23.669 -35.042 25.327 1.00 41.96 C \\\\nATOM 17 C SER A 3 -24.297 -33.802 25.968 1.00 41.96 C \\\\nATOM 18 CB SER A 3 -23.571 -34.885 23.804 1.00 41.96 C \\\\nATOM 19 O SER A 3 -25.347 -33.334 25.529 1.00 41.96 O \\\\nATOM 20 OG SER A 3 -24.856 -34.989 23.221 1.00 41.96 O \\\\nATOM 21 N ILE A 4 -23.663 -33.281 27.020 1.00 49.09 N \\\\nATOM 22 CA ILE A 4 -24.019 -32.004 27.645 1.00 49.09 C \\\\nATOM 23 C ILE A 4 -23.817 -30.914 26.587 1.00 49.09 C \\\\nATOM 24 CB ILE A 4 -23.162 -31.774 28.918 1.00 49.09 C \\\\nATOM 25 O ILE A 4 -22.683 -30.590 26.230 1.00 49.09 O \\\\nATOM 26 CG1 ILE A 4 -23.467 -32.865 29.975 1.00 49.09 C \\\\nATOM 27 CG2 ILE A 4 -23.401 -30.371 29.509 1.00 49.09 C \\\\nATOM 28 CD1 ILE A 4 -22.507 -32.870 31.172 1.00 49.09 C \\\\nATOM 29 N LEU A 5 -24.914 -30.374 26.051 1.00 54.35 N \\\\nATOM 30 CA LEU A 5 -24.866 -29.217 25.160 1.00 54.35 C \\\\nATOM 31 C LEU A 5 -24.174 -28.057 25.901 1.00 54.35 C \\\\nATOM 32 CB LEU A 5 -26.287 -28.820 24.715 1.00 54.35 C \\\\nATOM 33 O LEU A 5 -24.526 -27.781 27.052 1.00 54.35 O \\\\nATOM 34 CG LEU A 5 -26.968 -29.818 23.758 1.00 54.35 C \\\\nATOM 35 CD1 LEU A 5 -28.438 -29.436 23.583 1.00 54.35 C \\\\nATOM 36 CD2 LEU A 5 -26.309 -29.824 22.376 1.00 54.35 C \\\\nATOM 37 N PRO A 6 -23.190 -27.372 25.292 1.00 60.96 N \\\\nATOM 38 CA PRO A 6 -22.455 -26.309 25.964 1.00 60.96 C \\\\nATOM 39 C PRO A 6 -23.410 -25.182 26.380 1.00 60.96 C \\\\nATOM 40 CB PRO A 6 -21.373 -25.863 24.972 1.00 60.96 C \\\\nATOM 41 O PRO A 6 -24.093 -24.583 25.551 1.00 60.96 O \\\\nATOM 42 CG PRO A 6 -21.914 -26.299 23.609 1.00 60.96 C \\\\nATOM 43 CD PRO A 6 -22.720 -27.553 23.930 1.00 60.96 C \\\\nATOM 44 N PHE A 7 -23.456 -24.883 27.680 1.00 70.11 N \\\\nATOM 45 CA PHE A 7 -24.301 -23.825 28.228 1.00 70.11 C \\\\nATOM 46 C PHE A 7 -23.821 -22.449 27.741 1.00 70.11 C \\\\nATOM 47 CB PHE A 7 -24.316 -23.929 29.761 1.00 70.11 C \\\\nATOM 48 O PHE A 7 -22.785 -21.940 28.176 1.00 70.11 O \\\\nATOM 49 CG PHE A 7 -25.218 -22.917 30.448 1.00 70.11 C \\\\nATOM 50 CD1 PHE A 7 -24.682 -21.724 30.971 1.00 70.11 C \\\\nATOM 51 CD2 PHE A 7 -26.594 -23.180 30.586 1.00 70.11 C \\\\nATOM 52 CE1 PHE A 7 -25.515 -20.804 31.634 1.00 70.11 C \\\\nATOM 53 CE2 PHE A 7 -27.427 -22.259 31.246 1.00 70.11 C \\\\nATOM 54 CZ PHE A 7 -26.888 -21.073 31.773 1.00 70.11 C \\\\nATOM 55 N THR A 8 -24.572 -21.829 26.831 1.00 74.66 N \\\\nATOM 56 CA THR A 8 -24.329 -20.445 26.401 1.00 74.66 C \\\\nATOM 57 C THR A 8 -25.030 -19.480 27.363 1.00 74.66 C \\\\nATOM 58 CB THR A 8 -24.728 -20.221 24.936 1.00 74.66 C \\\\nATOM 59 O THR A 8 -26.260 -19.534 27.459 1.00 74.66 O \\\\nATOM 60 CG2 THR A 8 -24.478 -18.787 24.475 1.00 74.66 C \\\\nATOM 61 OG1 THR A 8 -23.883 -21.048 24.178 1.00 74.66 O \\\\nATOM 62 N PRO A 9 -24.291 -18.587 28.061 1.00 81.38 N \\\\nATOM 63 CA PRO A 9 -24.875 -17.665 29.034 1.00 81.38 C \\\\nATOM 64 C PRO A 9 -26.022 -16.833 28.430 1.00 81.38 C \\\\nATOM 65 CB PRO A 9 -23.725 -16.765 29.501 1.00 81.38 C \\\\nATOM 66 O PRO A 9 -25.880 -16.379 27.291 1.00 81.38 O \\\\nATOM 67 CG PRO A 9 -22.486 -17.630 29.288 1.00 81.38 C \\\\nATOM 68 CD PRO A 9 -22.839 -18.444 28.047 1.00 81.38 C \\\\nATOM 69 N PRO A 10 -27.113 -16.546 29.170 1.00 88.04 N \\\\nATOM 70 CA PRO A 10 -28.265 -15.803 28.643 1.00 88.04 C \\\\nATOM 71 C PRO A 10 -27.903 -14.455 28.006 1.00 88.04 C \\\\nATOM 72 CB PRO A 10 -29.206 -15.617 29.838 1.00 88.04 C \\\\nATOM 73 O PRO A 10 -28.428 -14.103 26.954 1.00 88.04 O \\\\nATOM 74 CG PRO A 10 -28.904 -16.831 30.714 1.00 88.04 C \\\\nATOM 75 CD PRO A 10 -27.408 -17.050 30.507 1.00 88.04 C \\\\nATOM 76 N VAL A 11 -26.942 -13.728 28.587 1.00 89.17 N \\\\nATOM 77 CA VAL A 11 -26.420 -12.472 28.018 1.00 89.17 C \\\\nATOM 78 C VAL A 11 -25.778 -12.654 26.641 1.00 89.17 C \\\\nATOM 79 CB VAL A 11 -25.444 -11.785 28.991 1.00 89.17 C \\\\nATOM 80 O VAL A 11 -25.989 -11.835 25.755 1.00 89.17 O \\\\nATOM 81 CG1 VAL A 11 -24.266 -12.670 29.436 1.00 89.17 C \\\\nATOM 82 CG2 VAL A 11 -24.874 -10.512 28.374 1.00 89.17 C \\\\nATOM 83 N VAL A 12 -25.047 -13.750 26.421 1.00 90.18 N \\\\nATOM 84 CA VAL A 12 -24.426 -14.037 25.121 1.00 90.18 C \\\\nATOM 85 C VAL A 12 -25.511 -14.301 24.081 1.00 90.18 C \\\\nATOM 86 CB VAL A 12 -23.450 -15.222 25.221 1.00 90.18 C \\\\nATOM 87 O VAL A 12 -25.415 -13.779 22.976 1.00 90.18 O \\\\nATOM 88 CG1 VAL A 12 -22.897 -15.653 23.860 1.00 90.18 C \\\\nATOM 89 CG2 VAL A 12 -22.261 -14.884 26.131 1.00 90.18 C \\\\nATOM 90 N LYS A 13 -26.567 -15.046 24.443 1.00 90.09 N \\\\nATOM 91 CA LYS A 13 -27.716 -15.269 23.551 1.00 90.09 C \\\\nATOM 92 C LYS A 13 -28.409 -13.955 23.179 1.00 90.09 C \\\\nATOM 93 CB LYS A 13 -28.730 -16.246 24.165 1.00 90.09 C \\\\nATOM 94 O LYS A 13 -28.685 -13.747 22.005 1.00 90.09 O \\\\nATOM 95 CG LYS A 13 -28.180 -17.668 24.349 1.00 90.09 C \\\\nATOM 96 CD LYS A 13 -29.318 -18.629 24.722 1.00 90.09 C \\\\nATOM 97 CE LYS A 13 -28.790 -20.054 24.924 1.00 90.09 C \\\\nATOM 98 NZ LYS A 13 -29.892 -21.005 25.223 1.00 90.09 N \\\\nATOM 99 N ARG A 14 -28.629 -13.054 24.148 1.00 91.11 N \\\\nATOM 100 CA ARG A 14 -29.205 -11.720 23.892 1.00 91.11 C \\\\nATOM 101 C ARG A 14 -28.332 -10.898 22.938 1.00 91.11 C \\\\nATOM 102 CB ARG A 14 -29.461 -10.958 25.206 1.00 91.11 C \\\\nATOM 103 O ARG A 14 -28.825 -10.440 21.917 1.00 91.11 O \\\\nATOM 104 CG ARG A 14 -30.632 -11.542 26.016 1.00 91.11 C \\\\nATOM 105 CD ARG A 14 -31.021 -10.655 27.210 1.00 91.11 C \\\\nATOM 106 NE ARG A 14 -29.967 -10.579 28.245 1.00 91.11 N \\\\nATOM 107 NH1 ARG A 14 -30.351 -8.417 28.976 1.00 91.11 N \\\\nATOM 108 NH2 ARG A 14 -28.636 -9.524 29.765 1.00 91.11 N \\\\nATOM 109 CZ ARG A 14 -29.674 -9.525 28.994 1.00 91.11 C \\\\nATOM 110 N LEU A 15 -27.028 -10.803 23.213 1.00 92.52 N \\\\nATOM 111 CA LEU A 15 -26.075 -10.061 22.377 1.00 92.52 C \\\\nATOM 112 C LEU A 15 -25.955 -10.606 20.948 1.00 92.52 C \\\\nATOM 113 CB LEU A 15 -24.703 -10.023 23.065 1.00 92.52 C \\\\nATOM 114 O LEU A 15 -25.822 -9.822 20.009 1.00 92.52 O \\\\nATOM 115 CG LEU A 15 -24.615 -9.069 24.270 1.00 92.52 C \\\\nATOM 116 CD1 LEU A 15 -23.259 -9.267 24.947 1.00 92.52 C \\\\nATOM 117 CD2 LEU A 15 -24.711 -7.596 23.880 1.00 92.52 C \\\\nATOM 118 N LEU A 16 -26.018 -11.929 20.780 1.00 91.58 N \\\\nATOM 119 CA LEU A 16 -26.069 -12.567 19.463 1.00 91.58 C \\\\nATOM 120 C LEU A 16 -27.408 -12.329 18.751 1.00 91.58 C \\\\nATOM 121 CB LEU A 16 -25.795 -14.073 19.608 1.00 91.58 C \\\\nATOM 122 O LEU A 16 -27.421 -12.254 17.529 1.00 91.58 O \\\\nATOM 123 CG LEU A 16 -24.336 -14.414 19.952 1.00 91.58 C \\\\nATOM 124 CD1 LEU A 16 -24.237 -15.887 20.345 1.00 91.58 C \\\\nATOM 125 CD2 LEU A 16 -23.386 -14.167 18.776 1.00 91.58 C \\\\nATOM 126 N GLY A 17 -28.506 -12.153 19.491 1.00 90.58 N \\\\nATOM 127 CA GLY A 17 -29.823 -11.820 18.939 1.00 90.58 C \\\\nATOM 128 C GLY A 17 -29.896 -10.443 18.269 1.00 90.58 C \\\\nATOM 129 O GLY A 17 -30.723 -10.244 17.387 1.00 90.58 O \\\\nATOM 130 N TRP A 18 -29.005 -9.510 18.625 1.00 91.39 N \\\\nATOM 131 CA TRP A 18 -28.865 -8.217 17.938 1.00 91.39 C \\\\nATOM 132 C TRP A 18 -27.843 -8.234 16.792 1.00 91.39 C \\\\nATOM 133 CB TRP A 18 -28.548 -7.112 18.953 1.00 91.39 C \\\\nATOM 134 O TRP A 18 -27.576 -7.184 16.202 1.00 91.39 O \\\\nATOM 135 CG TRP A 18 -29.603 -6.871 19.988 1.00 91.39 C \\\\nATOM 136 CD1 TRP A 18 -30.872 -6.473 19.747 1.00 91.39 C \\\\nATOM 137 CD2 TRP A 18 -29.499 -6.995 21.436 1.00 91.39 C \\\\nATOM 138 CE2 TRP A 18 -30.766 -6.701 22.015 1.00 91.39 C \\\\nATOM 139 CE3 TRP A 18 -28.444 -7.289 22.320 1.00 91.39 C \\\\nATOM 140 NE1 TRP A 18 -31.560 -6.364 20.941 1.00 91.39 N \\\\nATOM 141 CH2 TRP A 18 -29.924 -7.101 24.250 1.00 91.39 C \\\\nATOM 142 CZ2 TRP A 18 -30.987 -6.753 23.399 1.00 91.39 C \\\\nATOM 143 CZ3 TRP A 18 -28.652 -7.369 23.711 1.00 91.39 C \\\\nATOM 144 N LYS A 19 -27.241 -9.392 16.475 1.00 91.72 N \\\\nATOM 145 CA LYS A 19 -26.306 -9.514 15.351 1.00 91.72 C \\\\nATOM 146 C LYS A 19 -27.019 -9.139 14.049 1.00 91.72 C \\\\nATOM 147 CB LYS A 19 -25.718 -10.938 15.266 1.00 91.72 C \\\\nATOM 148 O LYS A 19 -28.107 -9.635 13.766 1.00 91.72 O \\\\nATOM 149 CG LYS A 19 -24.561 -11.002 14.256 1.00 91.72 C \\\\nATOM 150 CD LYS A 19 -23.988 -12.398 13.957 1.00 91.72 C \\\\nATOM 151 CE LYS A 19 -24.732 -13.086 12.796 1.00 91.72 C \\\\nATOM 152 NZ LYS A 19 -23.912 -14.127 12.109 1.00 91.72 N \\\\nATOM 153 N LYS A 20 -26.391 -8.297 13.232 1.00 89.42 N \\\\nATOM 154 CA LYS A 20 -26.866 -8.016 11.872 1.00 89.42 C \\\\nATOM 155 C LYS A 20 -26.457 -9.165 10.944 1.00 89.42 C \\\\nATOM 156 CB LYS A 20 -26.344 -6.646 11.412 1.00 89.42 C \\\\nATOM 157 O LYS A 20 -25.346 -9.681 11.042 1.00 89.42 O \\\\nATOM 158 CG LYS A 20 -26.864 -5.469 12.253 1.00 89.42 C \\\\nATOM 159 CD LYS A 20 -28.377 -5.244 12.136 1.00 89.42 C \\\\nATOM 160 CE LYS A 20 -28.752 -3.968 12.896 1.00 89.42 C \\\\nATOM 161 NZ LYS A 20 -30.202 -3.672 12.787 1.00 89.42 N \\\\nATOM 162 N SER A 21 -27.358 -9.582 10.060 1.00 76.73 N \\\\nATOM 163 CA SER A 21 -27.071 -10.613 9.052 1.00 76.73 C \\\\nATOM 164 C SER A 21 -26.585 -9.953 7.766 1.00 76.73 C \\\\nATOM 165 CB SER A 21 -28.301 -11.487 8.791 1.00 76.73 C \\\\nATOM 166 O SER A 21 -27.132 -8.922 7.375 1.00 76.73 O \\\\nATOM 167 OG SER A 21 -28.651 -12.154 9.990 1.00 76.73 O \\\\nATOM 168 N ALA A 22 -25.577 -10.531 7.110 1.00 64.94 N \\\\nATOM 169 CA ALA A 22 -25.187 -10.124 5.764 1.00 64.94 C \\\\nATOM 170 C ALA A 22 -26.336 -10.489 4.805 1.00 64.94 C \\\\nATOM 171 CB ALA A 22 -23.856 -10.800 5.410 1.00 64.94 C \\\\nATOM 172 O ALA A 22 -26.600 -11.663 4.556 1.00 64.94 O \\\\nATOM 173 N GLY A 23 -27.108 -9.492 4.371 1.00 48.74 N \\\\nATOM 174 CA GLY A 23 -28.290 -9.689 3.538 1.00 48.74 C \\\\nATOM 175 C GLY A 23 -27.919 -10.007 2.093 1.00 48.74 C \\\\nATOM 176 O GLY A 23 -27.514 -9.117 1.356 1.00 48.74 O \\\\nATOM 177 N GLY A 24 -28.113 -11.264 1.698 1.00 39.25 N \\\\nATOM 178 CA GLY A 24 -28.194 -11.733 0.318 1.00 39.25 C \\\\nATOM 179 C GLY A 24 -29.205 -12.877 0.266 1.00 39.25 C \\\\nATOM 180 O GLY A 24 -29.023 -13.914 0.899 1.00 39.25 O \\\\nATOM 181 N SER A 25 -30.318 -12.649 -0.416 1.00 33.12 N \\\\nATOM 182 CA SER A 25 -31.419 -13.586 -0.628 1.00 33.12 C \\\\nATOM 183 C SER A 25 -30.967 -14.913 -1.254 1.00 33.12 C \\\\nATOM 184 CB SER A 25 -32.416 -12.900 -1.572 1.00 33.12 C \\\\nATOM 185 O SER A 25 -30.346 -14.912 -2.309 1.00 33.12 O \\\\nATOM 186 OG SER A 25 -31.719 -12.289 -2.643 1.00 33.12 O \\\\nATOM 187 N GLY A 26 -31.363 -16.033 -0.638 1.00 28.12 N \\\\nATOM 188 CA GLY A 26 -31.713 -17.288 -1.318 1.00 28.12 C \\\\nATOM 189 C GLY A 26 -30.714 -17.865 -2.327 1.00 28.12 C \\\\nATOM 190 O GLY A 26 -31.011 -17.915 -3.514 1.00 28.12 O \\\\nATOM 191 N GLY A 27 -29.588 -18.400 -1.852 1.00 31.96 N \\\\nATOM 192 CA GLY A 27 -28.741 -19.320 -2.619 1.00 31.96 C \\\\nATOM 193 C GLY A 27 -28.473 -20.587 -1.809 1.00 31.96 C \\\\nATOM 194 O GLY A 27 -27.802 -20.534 -0.781 1.00 31.96 O \\\\nATOM 195 N ALA A 28 -29.004 -21.729 -2.247 1.00 35.83 N \\\\nATOM 196 CA ALA A 28 -29.006 -23.014 -1.534 1.00 35.83 C \\\\nATOM 197 C ALA A 28 -27.627 -23.724 -1.429 1.00 35.83 C \\\\nATOM 198 CB ALA A 28 -30.091 -23.891 -2.180 1.00 35.83 C \\\\nATOM 199 O ALA A 28 -27.569 -24.948 -1.371 1.00 35.83 O \\\\nATOM 200 N GLY A 29 -26.513 -22.981 -1.385 1.00 39.37 N \\\\nATOM 201 CA GLY A 29 -25.144 -23.526 -1.411 1.00 39.37 C \\\\nATOM 202 C GLY A 29 -24.241 -23.187 -0.213 1.00 39.37 C \\\\nATOM 203 O GLY A 29 -23.067 -23.534 -0.238 1.00 39.37 O \\\\nATOM 204 N GLY A 30 -24.737 -22.500 0.828 1.00 39.93 N \\\\nATOM 205 CA GLY A 30 -23.887 -21.862 1.859 1.00 39.93 C \\\\nATOM 206 C GLY A 30 -23.858 -22.484 3.267 1.00 39.93 C \\\\nATOM 207 O GLY A 30 -23.334 -21.854 4.188 1.00 39.93 O \\\\nATOM 208 N GLY A 31 -24.432 -23.674 3.480 1.00 42.15 N \\\\nATOM 209 CA GLY A 31 -24.710 -24.205 4.828 1.00 42.15 C \\\\nATOM 210 C GLY A 31 -23.492 -24.328 5.759 1.00 42.15 C \\\\nATOM 211 O GLY A 31 -23.576 -23.985 6.939 1.00 42.15 O \\\\nATOM 212 N GLU A 32 -22.342 -24.764 5.242 1.00 51.18 N \\\\nATOM 213 CA GLU A 32 -21.145 -24.982 6.069 1.00 51.18 C \\\\nATOM 214 C GLU A 32 -20.403 -23.684 6.416 1.00 51.18 C \\\\nATOM 215 CB GLU A 32 -20.194 -25.962 5.376 1.00 51.18 C \\\\nATOM 216 O GLU A 32 -19.970 -23.505 7.559 1.00 51.18 O \\\\nATOM 217 CG GLU A 32 -20.775 -27.382 5.322 1.00 51.18 C \\\\nATOM 218 CD GLU A 32 -19.740 -28.389 4.808 1.00 51.18 C \\\\nATOM 219 OE1 GLU A 32 -19.671 -29.487 5.403 1.00 51.18 O \\\\nATOM 220 OE2 GLU A 32 -19.012 -28.029 3.858 1.00 51.18 O \\\\nATOM 221 N GLN A 33 -20.293 -22.752 5.461 1.00 56.72 N \\\\nATOM 222 CA GLN A 33 -19.598 -21.478 5.677 1.00 56.72 C \\\\nATOM 223 C GLN A 33 -20.337 -20.610 6.701 1.00 56.72 C \\\\nATOM 224 CB GLN A 33 -19.417 -20.721 4.353 1.00 56.72 C \\\\nATOM 225 O GLN A 33 -19.711 -20.066 7.616 1.00 56.72 O \\\\nATOM 226 CG GLN A 33 -18.447 -21.436 3.398 1.00 56.72 C \\\\nATOM 227 CD GLN A 33 -18.143 -20.615 2.147 1.00 56.72 C \\\\nATOM 228 NE2 GLN A 33 -17.830 -21.246 1.038 1.00 56.72 N \\\\nATOM 229 OE1 GLN A 33 -18.163 -19.397 2.144 1.00 56.72 O \\\\nATOM 230 N ASN A 34 -21.671 -20.572 6.618 1.00 67.29 N \\\\nATOM 231 CA ASN A 34 -22.498 -19.839 7.573 1.00 67.29 C \\\\nATOM 232 C ASN A 34 -22.352 -20.414 8.999 1.00 67.29 C \\\\nATOM 233 CB ASN A 34 -23.947 -19.854 7.053 1.00 67.29 C \\\\nATOM 234 O ASN A 34 -22.158 -19.676 9.965 1.00 67.29 O \\\\nATOM 235 CG ASN A 34 -24.826 -18.811 7.724 1.00 67.29 C \\\\nATOM 236 ND2 ASN A 34 -26.122 -18.906 7.550 1.00 67.29 N \\\\nATOM 237 OD1 ASN A 34 -24.377 -17.899 8.394 1.00 67.29 O \\\\nATOM 238 N GLY A 35 -22.302 -21.746 9.141 1.00 76.97 N \\\\nATOM 239 CA GLY A 35 -22.104 -22.400 10.439 1.00 76.97 C \\\\nATOM 240 C GLY A 35 -20.735 -22.124 11.081 1.00 76.97 C \\\\nATOM 241 O GLY A 35 -20.624 -22.025 12.309 1.00 76.97 O \\\\nATOM 242 N GLN A 36 -19.672 -21.979 10.284 1.00 80.76 N \\\\nATOM 243 CA GLN A 36 -18.354 -21.600 10.805 1.00 80.76 C \\\\nATOM 244 C GLN A 36 -18.326 -20.136 11.266 1.00 80.76 C \\\\nATOM 245 CB GLN A 36 -17.275 -21.880 9.750 1.00 80.76 C \\\\nATOM 246 O GLN A 36 -17.717 -19.827 12.298 1.00 80.76 O \\\\nATOM 247 CG GLN A 36 -15.860 -21.709 10.331 1.00 80.76 C \\\\nATOM 248 CD GLN A 36 -14.756 -22.070 9.342 1.00 80.76 C \\\\nATOM 249 NE2 GLN A 36 -13.504 -22.038 9.743 1.00 80.76 N \\\\nATOM 250 OE1 GLN A 36 -14.971 -22.380 8.191 1.00 80.76 O \\\\nATOM 251 N GLU A 37 -18.996 -19.248 10.534 1.00 83.37 N \\\\nATOM 252 CA GLU A 37 -19.110 -17.836 10.887 1.00 83.37 C \\\\nATOM 253 C GLU A 37 -19.920 -17.630 12.171 1.00 83.37 C \\\\nATOM 254 CB GLU A 37 -19.705 -17.064 9.706 1.00 83.37 C \\\\nATOM 255 O GLU A 37 -19.465 -16.931 13.078 1.00 83.37 O \\\\nATOM 256 CG GLU A 37 -19.659 -15.560 9.998 1.00 83.37 C \\\\nATOM 257 CD GLU A 37 -20.107 -14.688 8.825 1.00 83.37 C \\\\nATOM 258 OE1 GLU A 37 -20.015 -13.455 9.018 1.00 83.37 O \\\\nATOM 259 OE2 GLU A 37 -20.523 -15.243 7.790 1.00 83.37 O \\\\nATOM 260 N GLU A 38 -21.059 -18.306 12.322 1.00 85.66 N \\\\nATOM 261 CA GLU A 38 -21.865 -18.251 13.546 1.00 85.66 C \\\\nATOM 262 C GLU A 38 -21.082 -18.708 14.781 1.00 85.66 C \\\\nATOM 263 CB GLU A 38 -23.114 -19.119 13.390 1.00 85.66 C \\\\nATOM 264 O GLU A 38 -21.068 -18.015 15.806 1.00 85.66 O \\\\nATOM 265 CG GLU A 38 -24.157 -18.467 12.474 1.00 85.66 C \\\\nATOM 266 CD GLU A 38 -25.460 -19.276 12.420 1.00 85.66 C \\\\nATOM 267 OE1 GLU A 38 -26.457 -18.690 11.946 1.00 85.66 O \\\\nATOM 268 OE2 GLU A 38 -25.466 -20.426 12.919 1.00 85.66 O \\\\nATOM 269 N LYS A 39 -20.345 -19.823 14.671 1.00 86.55 N \\\\nATOM 270 CA LYS A 39 -19.451 -20.302 15.740 1.00 86.55 C \\\\nATOM 271 C LYS A 39 -18.372 -19.274 16.081 1.00 86.55 C \\\\nATOM 272 CB LYS A 39 -18.795 -21.626 15.317 1.00 86.55 C \\\\nATOM 273 O LYS A 39 -17.981 -19.150 17.245 1.00 86.55 O \\\\nATOM 274 CG LYS A 39 -19.767 -22.812 15.382 1.00 86.55 C \\\\nATOM 275 CD LYS A 39 -19.109 -24.081 14.822 1.00 86.55 C \\\\nATOM 276 CE LYS A 39 -20.135 -25.219 14.776 1.00 86.55 C \\\\nATOM 277 NZ LYS A 39 -19.592 -26.445 14.136 1.00 86.55 N \\\\nATOM 278 N TRP A 40 -17.863 -18.545 15.089 1.00 88.25 N \\\\nATOM 279 CA TRP A 40 -16.889 -17.482 15.316 1.00 88.25 C \\\\nATOM 280 C TRP A 40 -17.515 -16.281 16.041 1.00 88.25 C \\\\nATOM 281 CB TRP A 40 -16.221 -17.086 13.997 1.00 88.25 C \\\\nATOM 282 O TRP A 40 -16.951 -15.825 17.040 1.00 88.25 O \\\\nATOM 283 CG TRP A 40 -15.165 -16.048 14.177 1.00 88.25 C \\\\nATOM 284 CD1 TRP A 40 -13.860 -16.285 14.429 1.00 88.25 C \\\\nATOM 285 CD2 TRP A 40 -15.322 -14.598 14.178 1.00 88.25 C \\\\nATOM 286 CE2 TRP A 40 -14.050 -14.013 14.456 1.00 88.25 C \\\\nATOM 287 CE3 TRP A 40 -16.408 -13.723 13.961 1.00 88.25 C \\\\nATOM 288 NE1 TRP A 40 -13.204 -15.089 14.630 1.00 88.25 N \\\\nATOM 289 CH2 TRP A 40 -14.955 -11.783 14.248 1.00 88.25 C \\\\nATOM 290 CZ2 TRP A 40 -13.857 -12.626 14.495 1.00 88.25 C \\\\nATOM 291 CZ3 TRP A 40 -16.226 -12.329 13.998 1.00 88.25 C \\\\nATOM 292 N CYS A 41 -18.700 -15.828 15.616 1.00 90.26 N \\\\nATOM 293 CA CYS A 41 -19.451 -14.756 16.275 1.00 90.26 C \\\\nATOM 294 C CYS A 41 -19.745 -15.096 17.741 1.00 90.26 C \\\\nATOM 295 CB CYS A 41 -20.771 -14.510 15.529 1.00 90.26 C \\\\nATOM 296 O CYS A 41 -19.511 -14.274 18.629 1.00 90.26 O \\\\nATOM 297 SG CYS A 41 -20.480 -13.830 13.874 1.00 90.26 S \\\\nATOM 298 N GLU A 42 -20.186 -16.325 18.023 1.00 90.51 N \\\\nATOM 299 CA GLU A 42 -20.450 -16.772 19.390 1.00 90.51 C \\\\nATOM 300 C GLU A 42 -19.185 -16.721 20.259 1.00 90.51 C \\\\nATOM 301 CB GLU A 42 -21.072 -18.176 19.365 1.00 90.51 C \\\\nATOM 302 O GLU A 42 -19.226 -16.228 21.390 1.00 90.51 O \\\\nATOM 303 CG GLU A 42 -21.423 -18.629 20.789 1.00 90.51 C \\\\nATOM 304 CD GLU A 42 -22.094 -19.999 20.874 1.00 90.51 C \\\\nATOM 305 OE1 GLU A 42 -22.668 -20.264 21.960 1.00 90.51 O \\\\nATOM 306 OE2 GLU A 42 -21.847 -20.845 20.000 1.00 90.51 O \\\\nATOM 307 N LYS A 43 -18.035 -17.168 19.737 1.00 89.89 N \\\\nATOM 308 CA LYS A 43 -16.750 -17.069 20.449 1.00 89.89 C \\\\nATOM 309 C LYS A 43 -16.331 -15.615 20.685 1.00 89.89 C \\\\nATOM 310 CB LYS A 43 -15.656 -17.823 19.682 1.00 89.89 C \\\\nATOM 311 O LYS A 43 -15.843 -15.308 21.776 1.00 89.89 O \\\\nATOM 312 CG LYS A 43 -15.801 -19.351 19.770 1.00 89.89 C \\\\nATOM 313 CD LYS A 43 -14.681 -20.010 18.954 1.00 89.89 C \\\\nATOM 314 CE LYS A 43 -14.843 -21.529 18.842 1.00 89.89 C \\\\nATOM 315 NZ LYS A 43 -13.695 -22.134 18.114 1.00 89.89 N \\\\nATOM 316 N ALA A 44 -16.529 -14.728 19.707 1.00 90.90 N \\\\nATOM 317 CA ALA A 44 -16.215 -13.304 19.832 1.00 90.90 C \\\\nATOM 318 C ALA A 44 -17.040 -12.649 20.951 1.00 90.90 C \\\\nATOM 319 CB ALA A 44 -16.439 -12.611 18.479 1.00 90.90 C \\\\nATOM 320 O ALA A 44 -16.475 -12.035 21.857 1.00 90.90 O \\\\nATOM 321 N VAL A 45 -18.359 -12.866 20.957 1.00 93.13 N \\\\nATOM 322 CA VAL A 45 -19.264 -12.328 21.985 1.00 93.13 C \\\\nATOM 323 C VAL A 45 -18.977 -12.940 23.359 1.00 93.13 C \\\\nATOM 324 CB VAL A 45 -20.738 -12.517 21.575 1.00 93.13 C \\\\nATOM 325 O VAL A 45 -18.897 -12.206 24.342 1.00 93.13 O \\\\nATOM 326 CG1 VAL A 45 -21.709 -12.028 22.656 1.00 93.13 C \\\\nATOM 327 CG2 VAL A 45 -21.050 -11.716 20.305 1.00 93.13 C \\\\nATOM 328 N LYS A 46 -18.734 -14.257 23.460 1.00 90.75 N \\\\nATOM 329 CA LYS A 46 -18.327 -14.904 24.727 1.00 90.75 C \\\\nATOM 330 C LYS A 46 -17.047 -14.284 25.295 1.00 90.75 C \\\\nATOM 331 CB LYS A 46 -18.140 -16.425 24.535 1.00 90.75 C \\\\nATOM 332 O LYS A 46 -16.974 -14.020 26.497 1.00 90.75 O \\\\nATOM 333 CG LYS A 46 -19.477 -17.178 24.493 1.00 90.75 C \\\\nATOM 334 CD LYS A 46 -19.334 -18.690 24.241 1.00 90.75 C \\\\nATOM 335 CE LYS A 46 -20.738 -19.316 24.203 1.00 90.75 C \\\\nATOM 336 NZ LYS A 46 -20.772 -20.741 23.784 1.00 90.75 N \\\\nATOM 337 N SER A 47 -16.056 -14.031 24.437 1.00 89.31 N \\\\nATOM 338 CA SER A 47 -14.799 -13.380 24.817 1.00 89.31 C \\\\nATOM 339 C SER A 47 -15.031 -11.948 25.303 1.00 89.31 C \\\\nATOM 340 CB SER A 47 -13.825 -13.406 23.636 1.00 89.31 C \\\\nATOM 341 O SER A 47 -14.521 -11.576 26.363 1.00 89.31 O \\\\nATOM 342 OG SER A 47 -12.541 -12.957 24.032 1.00 89.31 O \\\\nATOM 343 N LEU A 48 -15.863 -11.169 24.599 1.00 92.11 N \\\\nATOM 344 CA LEU A 48 -16.211 -9.811 25.014 1.00 92.11 C \\\\nATOM 345 C LEU A 48 -16.908 -9.789 26.372 1.00 92.11 C \\\\nATOM 346 CB LEU A 48 -17.112 -9.131 23.972 1.00 92.11 C \\\\nATOM 347 O LEU A 48 -16.472 -9.073 27.267 1.00 92.11 O \\\\nATOM 348 CG LEU A 48 -17.369 -7.649 24.313 1.00 92.11 C \\\\nATOM 349 CD1 LEU A 48 -16.103 -6.796 24.387 1.00 92.11 C \\\\nATOM 350 CD2 LEU A 48 -18.318 -7.034 23.304 1.00 92.11 C \\\\nATOM 351 N VAL A 49 -17.948 -10.606 26.555 1.00 92.83 N \\\\nATOM 352 CA VAL A 49 -18.707 -10.674 27.811 1.00 92.83 C \\\\nATOM 353 C VAL A 49 -17.786 -11.020 28.981 1.00 92.83 C \\\\nATOM 354 CB VAL A 49 -19.863 -11.686 27.690 1.00 92.83 C \\\\nATOM 355 O VAL A 49 -17.889 -10.408 30.042 1.00 92.83 O \\\\nATOM 356 CG1 VAL A 49 -20.549 -11.969 29.034 1.00 92.83 C \\\\nATOM 357 CG2 VAL A 49 -20.943 -11.156 26.741 1.00 92.83 C \\\\nATOM 358 N LYS A 50 -16.836 -11.949 28.798 1.00 89.33 N \\\\nATOM 359 CA LYS A 50 -15.842 -12.282 29.831 1.00 89.33 C \\\\nATOM 360 C LYS A 50 -14.967 -11.079 30.205 1.00 89.33 C \\\\nATOM 361 CB LYS A 50 -14.997 -13.479 29.361 1.00 89.33 C \\\\nATOM 362 O LYS A 50 -14.634 -10.933 31.378 1.00 89.33 O \\\\nATOM 363 CG LYS A 50 -14.066 -14.014 30.465 1.00 89.33 C \\\\nATOM 364 CD LYS A 50 -13.259 -15.231 29.984 1.00 89.33 C \\\\nATOM 365 CE LYS A 50 -12.365 -15.766 31.114 1.00 89.33 C \\\\nATOM 366 NZ LYS A 50 -11.588 -16.967 30.703 1.00 89.33 N \\\\nATOM 367 N LYS A 51 -14.597 -10.230 29.238 1.00 88.71 N \\\\nATOM 368 CA LYS A 51 -13.817 -9.003 29.480 1.00 88.71 C \\\\nATOM 369 C LYS A 51 -14.659 -7.919 30.158 1.00 88.71 C \\\\nATOM 370 CB LYS A 51 -13.192 -8.490 28.171 1.00 88.71 C \\\\nATOM 371 O LYS A 51 -14.231 -7.385 31.174 1.00 88.71 O \\\\nATOM 372 CG LYS A 51 -12.089 -9.419 27.637 1.00 88.71 C \\\\nATOM 373 CD LYS A 51 -11.479 -8.842 26.352 1.00 88.71 C \\\\nATOM 374 CE LYS A 51 -10.367 -9.752 25.816 1.00 88.71 C \\\\nATOM 375 NZ LYS A 51 -9.566 -9.062 24.772 1.00 88.71 N \\\\nATOM 376 N LEU A 52 -15.874 -7.662 29.674 1.00 92.02 N \\\\nATOM 377 CA LEU A 52 -16.737 -6.597 30.202 1.00 92.02 C \\\\nATOM 378 C LEU A 52 -17.308 -6.897 31.591 1.00 92.02 C \\\\nATOM 379 CB LEU A 52 -17.871 -6.289 29.216 1.00 92.02 C \\\\nATOM 380 O LEU A 52 -17.553 -5.970 32.358 1.00 92.02 O \\\\nATOM 381 CG LEU A 52 -17.411 -5.796 27.835 1.00 92.02 C \\\\nATOM 382 CD1 LEU A 52 -18.646 -5.450 27.015 1.00 92.02 C \\\\nATOM 383 CD2 LEU A 52 -16.510 -4.565 27.878 1.00 92.02 C \\\\nATOM 384 N LYS A 53 -17.466 -8.177 31.956 1.00 90.21 N \\\\nATOM 385 CA LYS A 53 -17.799 -8.568 33.336 1.00 90.21 C \\\\nATOM 386 C LYS A 53 -16.706 -8.190 34.335 1.00 90.21 C \\\\nATOM 387 CB LYS A 53 -18.079 -10.075 33.425 1.00 90.21 C \\\\nATOM 388 O LYS A 53 -17.027 -7.907 35.480 1.00 90.21 O \\\\nATOM 389 CG LYS A 53 -19.488 -10.416 32.930 1.00 90.21 C \\\\nATOM 390 CD LYS A 53 -19.791 -11.901 33.151 1.00 90.21 C \\\\nATOM 391 CE LYS A 53 -21.242 -12.185 32.753 1.00 90.21 C \\\\nATOM 392 NZ LYS A 53 -21.682 -13.518 33.232 1.00 90.21 N \\\\nATOM 393 N LYS A 54 -15.435 -8.178 33.916 1.00 86.28 N \\\\nATOM 394 CA LYS A 54 -14.317 -7.762 34.778 1.00 86.28 C \\\\nATOM 395 C LYS A 54 -14.244 -6.244 34.944 1.00 86.28 C \\\\nATOM 396 CB LYS A 54 -12.983 -8.291 34.238 1.00 86.28 C \\\\nATOM 397 O LYS A 54 -13.834 -5.789 36.000 1.00 86.28 O \\\\nATOM 398 CG LYS A 54 -12.859 -9.818 34.308 1.00 86.28 C \\\\nATOM 399 CD LYS A 54 -11.468 -10.222 33.806 1.00 86.28 C \\\\nATOM 400 CE LYS A 54 -11.221 -11.720 33.988 1.00 86.28 C \\\\nATOM 401 NZ LYS A 54 -9.779 -12.030 33.803 1.00 86.28 N \\\\nATOM 402 N THR A 55 -14.635 -5.479 33.922 1.00 85.96 N \\\\nATOM 403 CA THR A 55 -14.583 -4.005 33.936 1.00 85.96 C \\\\nATOM 404 C THR A 55 -15.893 -3.341 34.372 1.00 85.96 C \\\\nATOM 405 CB THR A 55 -14.146 -3.452 32.568 1.00 85.96 C \\\\nATOM 406 O THR A 55 -15.940 -2.122 34.496 1.00 85.96 O \\\\nATOM 407 CG2 THR A 55 -12.763 -3.949 32.150 1.00 85.96 C \\\\nATOM 408 OG1 THR A 55 -15.038 -3.846 31.547 1.00 85.96 O \\\\nATOM 409 N GLY A 56 -16.972 -4.108 34.575 1.00 88.71 N \\\\nATOM 410 CA GLY A 56 -18.290 -3.575 34.942 1.00 88.71 C \\\\nATOM 411 C GLY A 56 -18.988 -2.791 33.821 1.00 88.71 C \\\\nATOM 412 O GLY A 56 -19.892 -2.010 34.088 1.00 88.71 O \\\\nATOM 413 N ARG A 57 -18.578 -2.970 32.557 1.00 89.65 N \\\\nATOM 414 CA ARG A 57 -19.094 -2.215 31.392 1.00 89.65 C \\\\nATOM 415 C ARG A 57 -20.141 -2.977 30.570 1.00 89.65 C \\\\nATOM 416 CB ARG A 57 -17.914 -1.754 30.516 1.00 89.65 C \\\\nATOM 417 O ARG A 57 -20.518 -2.529 29.490 1.00 89.65 O \\\\nATOM 418 CG ARG A 57 -16.913 -0.808 31.193 1.00 89.65 C \\\\nATOM 419 CD ARG A 57 -17.510 0.564 31.522 1.00 89.65 C \\\\nATOM 420 NE ARG A 57 -16.465 1.467 32.040 1.00 89.65 N \\\\nATOM 421 NH1 ARG A 57 -17.446 3.467 31.478 1.00 89.65 N \\\\nATOM 422 NH2 ARG A 57 -15.450 3.456 32.477 1.00 89.65 N \\\\nATOM 423 CZ ARG A 57 -16.463 2.787 32.001 1.00 89.65 C \\\\nATOM 424 N LEU A 58 -20.583 -4.146 31.039 1.00 92.08 N \\\\nATOM 425 CA LEU A 58 -21.513 -5.006 30.299 1.00 92.08 C \\\\nATOM 426 C LEU A 58 -22.893 -4.354 30.123 1.00 92.08 C \\\\nATOM 427 CB LEU A 58 -21.603 -6.366 31.010 1.00 92.08 C \\\\nATOM 428 O LEU A 58 -23.426 -4.374 29.017 1.00 92.08 O \\\\nATOM 429 CG LEU A 58 -22.493 -7.403 30.296 1.00 92.08 C \\\\nATOM 430 CD1 LEU A 58 -21.978 -7.747 28.893 1.00 92.08 C \\\\nATOM 431 CD2 LEU A 58 -22.483 -8.687 31.132 1.00 92.08 C \\\\nATOM 432 N ASP A 59 -23.422 -3.728 31.174 1.00 92.16 N \\\\nATOM 433 CA ASP A 59 -24.736 -3.072 31.134 1.00 92.16 C \\\\nATOM 434 C ASP A 59 -24.733 -1.855 30.197 1.00 92.16 C \\\\nATOM 435 CB ASP A 59 -25.151 -2.655 32.554 1.00 92.16 C \\\\nATOM 436 O ASP A 59 -25.700 -1.618 29.476 1.00 92.16 O \\\\nATOM 437 CG ASP A 59 -25.249 -3.839 33.523 1.00 92.16 C \\\\nATOM 438 OD1 ASP A 59 -25.561 -4.960 33.061 1.00 92.16 O \\\\nATOM 439 OD2 ASP A 59 -24.929 -3.629 34.711 1.00 92.16 O \\\\nATOM 440 N GLU A 60 -23.615 -1.123 30.132 1.00 92.46 N \\\\nATOM 441 CA GLU A 60 -23.435 -0.012 29.188 1.00 92.46 C \\\\nATOM 442 C GLU A 60 -23.424 -0.503 27.732 1.00 92.46 C \\\\nATOM 443 CB GLU A 60 -22.143 0.763 29.502 1.00 92.46 C \\\\nATOM 444 O GLU A 60 -24.003 0.152 26.867 1.00 92.46 O \\\\nATOM 445 CG GLU A 60 -22.169 1.524 30.841 1.00 92.46 C \\\\nATOM 446 CD GLU A 60 -23.135 2.728 30.898 1.00 92.46 C \\\\nATOM 447 OE1 GLU A 60 -23.315 3.275 32.013 1.00 92.46 O \\\\nATOM 448 OE2 GLU A 60 -23.622 3.188 29.838 1.00 92.46 O \\\\nATOM 449 N LEU A 61 -22.840 -1.678 27.449 1.00 93.87 N \\\\nATOM 450 CA LEU A 61 -22.908 -2.284 26.114 1.00 93.87 C \\\\nATOM 451 C LEU A 61 -24.337 -2.705 25.755 1.00 93.87 C \\\\nATOM 452 CB LEU A 61 -21.944 -3.481 26.011 1.00 93.87 C \\\\nATOM 453 O LEU A 61 -24.794 -2.415 24.650 1.00 93.87 O \\\\nATOM 454 CG LEU A 61 -21.969 -4.148 24.618 1.00 93.87 C \\\\nATOM 455 CD1 LEU A 61 -21.420 -3.231 23.519 1.00 93.87 C \\\\nATOM 456 CD2 LEU A 61 -21.150 -5.433 24.618 1.00 93.87 C \\\\nATOM 457 N GLU A 62 -25.045 -3.378 26.668 1.00 93.54 N \\\\nATOM 458 CA GLU A 62 -26.443 -3.769 26.441 1.00 93.54 C \\\\nATOM 459 C GLU A 62 -27.325 -2.540 26.204 1.00 93.54 C \\\\nATOM 460 CB GLU A 62 -26.995 -4.589 27.621 1.00 93.54 C \\\\nATOM 461 O GLU A 62 -28.126 -2.525 25.266 1.00 93.54 O \\\\nATOM 462 CG GLU A 62 -26.402 -6.004 27.667 1.00 93.54 C \\\\nATOM 463 CD GLU A 62 -27.088 -6.953 28.667 1.00 93.54 C \\\\nATOM 464 OE1 GLU A 62 -26.574 -8.083 28.830 1.00 93.54 O \\\\nATOM 465 OE2 GLU A 62 -28.202 -6.695 29.181 1.00 93.54 O \\\\nATOM 466 N LYS A 63 -27.129 -1.479 26.994 1.00 93.28 N \\\\nATOM 467 CA LYS A 63 -27.811 -0.197 26.818 1.00 93.28 C \\\\nATOM 468 C LYS A 63 -27.486 0.430 25.467 1.00 93.28 C \\\\nATOM 469 CB LYS A 63 -27.437 0.728 27.983 1.00 93.28 C \\\\nATOM 470 O LYS A 63 -28.412 0.847 24.775 1.00 93.28 O \\\\nATOM 471 CG LYS A 63 -28.233 2.040 27.961 1.00 93.28 C \\\\nATOM 472 CD LYS A 63 -27.803 2.920 29.138 1.00 93.28 C \\\\nATOM 473 CE LYS A 63 -28.577 4.240 29.125 1.00 93.28 C \\\\nATOM 474 NZ LYS A 63 -28.150 5.106 30.250 1.00 93.28 N \\\\nATOM 475 N ALA A 64 -26.217 0.479 25.066 1.00 93.52 N \\\\nATOM 476 CA ALA A 64 -25.806 1.046 23.784 1.00 93.52 C \\\\nATOM 477 C ALA A 64 -26.443 0.309 22.596 1.00 93.52 C \\\\nATOM 478 CB ALA A 64 -24.277 1.032 23.700 1.00 93.52 C \\\\nATOM 479 O ALA A 64 -27.006 0.953 21.716 1.00 93.52 O \\\\nATOM 480 N ILE A 65 -26.426 -1.029 22.605 1.00 93.03 N \\\\nATOM 481 CA ILE A 65 -27.017 -1.851 21.537 1.00 93.03 C \\\\nATOM 482 C ILE A 65 -28.545 -1.735 21.510 1.00 93.03 C \\\\nATOM 483 CB ILE A 65 -26.532 -3.315 21.639 1.00 93.03 C \\\\nATOM 484 O ILE A 65 -29.130 -1.622 20.437 1.00 93.03 O \\\\nATOM 485 CG1 ILE A 65 -25.006 -3.390 21.390 1.00 93.03 C \\\\nATOM 486 CG2 ILE A 65 -27.264 -4.212 20.620 1.00 93.03 C \\\\nATOM 487 CD1 ILE A 65 -24.401 -4.746 21.764 1.00 93.03 C \\\\nATOM 488 N THR A 66 -29.194 -1.718 22.676 1.00 92.60 N \\\\nATOM 489 CA THR A 66 -30.662 -1.653 22.763 1.00 92.60 C \\\\nATOM 490 C THR A 66 -31.198 -0.273 22.379 1.00 92.60 C \\\\nATOM 491 CB THR A 66 -31.146 -2.028 24.174 1.00 92.60 C \\\\nATOM 492 O THR A 66 -32.177 -0.171 21.647 1.00 92.60 O \\\\nATOM 493 CG2 THR A 66 -32.667 -2.135 24.269 1.00 92.60 C \\\\nATOM 494 OG1 THR A 66 -30.633 -3.284 24.551 1.00 92.60 O \\\\nATOM 495 N THR A 67 -30.559 0.797 22.863 1.00 92.64 N \\\\nATOM 496 CA THR A 67 -31.003 2.185 22.623 1.00 92.64 C \\\\nATOM 497 C THR A 67 -30.495 2.773 21.314 1.00 92.64 C \\\\nATOM 498 CB THR A 67 -30.606 3.133 23.765 1.00 92.64 C \\\\nATOM 499 O THR A 67 -31.008 3.799 20.880 1.00 92.64 O \\\\nATOM 500 CG2 THR A 67 -31.188 2.700 25.110 1.00 92.64 C \\\\nATOM 501 OG1 THR A 67 -29.206 3.215 23.915 1.00 92.64 O \\\\nATOM 502 N GLN A 68 -29.488 2.148 20.700 1.00 91.97 N \\\\nATOM 503 CA GLN A 68 -28.839 2.620 19.478 1.00 91.97 C \\\\nATOM 504 C GLN A 68 -28.338 4.071 19.573 1.00 91.97 C \\\\nATOM 505 CB GLN A 68 -29.736 2.359 18.258 1.00 91.97 C \\\\nATOM 506 O GLN A 68 -28.393 4.832 18.609 1.00 91.97 O \\\\nATOM 507 CG GLN A 68 -30.251 0.912 18.216 1.00 91.97 C \\\\nATOM 508 CD GLN A 68 -30.759 0.500 16.843 1.00 91.97 C \\\\nATOM 509 NE2 GLN A 68 -31.744 -0.367 16.782 1.00 91.97 N \\\\nATOM 510 OE1 GLN A 68 -30.267 0.904 15.800 1.00 91.97 O \\\\nATOM 511 N ASN A 69 -27.872 4.466 20.760 1.00 89.65 N \\\\nATOM 512 CA ASN A 69 -27.577 5.856 21.090 1.00 89.65 C \\\\nATOM 513 C ASN A 69 -26.068 6.099 21.251 1.00 89.65 C \\\\nATOM 514 CB ASN A 69 -28.402 6.229 22.331 1.00 89.65 C \\\\nATOM 515 O ASN A 69 -25.402 5.468 22.080 1.00 89.65 O \\\\nATOM 516 CG ASN A 69 -28.392 7.714 22.640 1.00 89.65 C \\\\nATOM 517 ND2 ASN A 69 -29.345 8.179 23.410 1.00 89.65 N \\\\nATOM 518 OD1 ASN A 69 -27.539 8.474 22.219 1.00 89.65 O \\\\nATOM 519 N CYS A 70 -25.540 7.065 20.499 1.00 90.18 N \\\\nATOM 520 CA CYS A 70 -24.140 7.490 20.554 1.00 90.18 C \\\\nATOM 521 C CYS A 70 -23.754 8.189 21.873 1.00 90.18 C \\\\nATOM 522 CB CYS A 70 -23.859 8.383 19.337 1.00 90.18 C \\\\nATOM 523 O CYS A 70 -22.586 8.165 22.245 1.00 90.18 O \\\\nATOM 524 SG CYS A 70 -24.988 9.806 19.301 1.00 90.18 S \\\\nATOM 525 N ASN A 71 -24.720 8.727 22.625 1.00 91.25 N \\\\nATOM 526 CA ASN A 71 -24.501 9.393 23.918 1.00 91.25 C \\\\nATOM 527 C ASN A 71 -24.326 8.416 25.098 1.00 91.25 C \\\\nATOM 528 CB ASN A 71 -25.653 10.379 24.174 1.00 91.25 C \\\\nATOM 529 O ASN A 71 -24.219 8.830 26.252 1.00 91.25 O \\\\nATOM 530 CG ASN A 71 -25.709 11.485 23.138 1.00 91.25 C \\\\nATOM 531 ND2 ASN A 71 -26.879 11.845 22.666 1.00 91.25 N \\\\nATOM 532 OD1 ASN A 71 -24.702 12.045 22.745 1.00 91.25 O \\\\nATOM 533 N THR A 72 -24.336 7.107 24.840 1.00 92.41 N \\\\nATOM 534 CA THR A 72 -23.986 6.097 25.850 1.00 92.41 C \\\\nATOM 535 C THR A 72 -22.507 6.193 26.239 1.00 92.41 C \\\\nATOM 536 CB THR A 72 -24.354 4.682 25.377 1.00 92.41 C \\\\nATOM 537 O THR A 72 -21.696 6.758 25.505 1.00 92.41 O \\\\nATOM 538 CG2 THR A 72 -25.874 4.478 25.331 1.00 92.41 C \\\\nATOM 539 OG1 THR A 72 -23.835 4.411 24.093 1.00 92.41 O \\\\nATOM 540 N LYS A 73 -22.125 5.663 27.410 1.00 93.98 N \\\\nATOM 541 CA LYS A 73 -20.726 5.719 27.862 1.00 93.98 C \\\\nATOM 542 C LYS A 73 -19.822 4.856 26.976 1.00 93.98 C \\\\nATOM 543 CB LYS A 73 -20.611 5.312 29.339 1.00 93.98 C \\\\nATOM 544 O LYS A 73 -20.266 3.904 26.332 1.00 93.98 O \\\\nATOM 545 CG LYS A 73 -21.291 6.319 30.278 1.00 93.98 C \\\\nATOM 546 CD LYS A 73 -21.077 5.906 31.737 1.00 93.98 C \\\\nATOM 547 CE LYS A 73 -21.893 6.794 32.679 1.00 93.98 C \\\\nATOM 548 NZ LYS A 73 -21.996 6.174 34.021 1.00 93.98 N \\\\nATOM 549 N CYS A 74 -18.523 5.163 26.980 1.00 94.08 N \\\\nATOM 550 CA CYS A 74 -17.531 4.311 26.328 1.00 94.08 C \\\\nATOM 551 C CYS A 74 -17.552 2.905 26.948 1.00 94.08 C \\\\nATOM 552 CB CYS A 74 -16.129 4.936 26.412 1.00 94.08 C \\\\nATOM 553 O CYS A 74 -17.532 2.745 28.173 1.00 94.08 O \\\\nATOM 554 SG CYS A 74 -16.008 6.429 25.382 1.00 94.08 S \\\\nATOM 555 N VAL A 75 -17.562 1.888 26.088 1.00 94.76 N \\\\nATOM 556 CA VAL A 75 -17.382 0.483 26.468 1.00 94.76 C \\\\nATOM 557 C VAL A 75 -15.969 0.112 26.067 1.00 94.76 C \\\\nATOM 558 CB VAL A 75 -18.406 -0.431 25.770 1.00 94.76 C \\\\nATOM 559 O VAL A 75 -15.702 -0.009 24.878 1.00 94.76 O \\\\nATOM 560 CG1 VAL A 75 -18.184 -1.901 26.146 1.00 94.76 C \\\\nATOM 561 CG2 VAL A 75 -19.841 -0.057 26.150 1.00 94.76 C \\\\nATOM 562 N THR A 76 -15.059 -0.032 27.023 1.00 93.46 N \\\\nATOM 563 CA THR A 76 -13.633 -0.205 26.735 1.00 93.46 C \\\\nATOM 564 C THR A 76 -13.158 -1.636 26.965 1.00 93.46 C \\\\nATOM 565 CB THR A 76 -12.778 0.807 27.509 1.00 93.46 C \\\\nATOM 566 O THR A 76 -13.692 -2.372 27.801 1.00 93.46 O \\\\nATOM 567 CG2 THR A 76 -13.114 2.240 27.106 1.00 93.46 C \\\\nATOM 568 OG1 THR A 76 -12.960 0.698 28.899 1.00 93.46 O \\\\nATOM 569 N ILE A 77 -12.156 -2.050 26.189 1.00 90.10 N \\\\nATOM 570 CA ILE A 77 -11.353 -3.243 26.468 1.00 90.10 C \\\\nATOM 571 C ILE A 77 -9.863 -2.894 26.371 1.00 90.10 C \\\\nATOM 572 CB ILE A 77 -11.712 -4.433 25.550 1.00 90.10 C \\\\nATOM 573 O ILE A 77 -9.518 -2.003 25.590 1.00 90.10 O \\\\nATOM 574 CG1 ILE A 77 -11.311 -4.212 24.075 1.00 90.10 C \\\\nATOM 575 CG2 ILE A 77 -13.194 -4.824 25.678 1.00 90.10 C \\\\nATOM 576 CD1 ILE A 77 -11.446 -5.492 23.246 1.00 90.10 C \\\\nATOM 577 N PRO A 78 -8.974 -3.630 27.063 1.00 85.17 N \\\\nATOM 578 CA PRO A 78 -7.536 -3.446 26.912 1.00 85.17 C \\\\nATOM 579 C PRO A 78 -7.113 -3.584 25.447 1.00 85.17 C \\\\nATOM 580 CB PRO A 78 -6.879 -4.504 27.802 1.00 85.17 C \\\\nATOM 581 O PRO A 78 -7.439 -4.582 24.787 1.00 85.17 O \\\\nATOM 582 CG PRO A 78 -7.942 -4.768 28.866 1.00 85.17 C \\\\nATOM 583 CD PRO A 78 -9.253 -4.611 28.100 1.00 85.17 C \\\\nATOM 584 N SER A 79 -6.401 -2.580 24.949 1.00 71.62 N \\\\nATOM 585 CA SER A 79 -5.681 -2.636 23.687 1.00 71.62 C \\\\nATOM 586 C SER A 79 -4.462 -3.539 23.896 1.00 71.62 C \\\\nATOM 587 CB SER A 79 -5.308 -1.217 23.219 1.00 71.62 C \\\\nATOM 588 O SER A 79 -3.763 -3.440 24.900 1.00 71.62 O \\\\nATOM 589 OG SER A 79 -4.110 -0.770 23.807 1.00 71.62 O \\\\nATOM 590 N THR A 80 -4.172 -4.464 22.983 1.00 59.90 N \\\\nATOM 591 CA THR A 80 -2.960 -5.301 23.097 1.00 59.90 C \\\\nATOM 592 C THR A 80 -1.685 -4.537 22.707 1.00 59.90 C \\\\nATOM 593 CB THR A 80 -3.101 -6.618 22.320 1.00 59.90 C \\\\nATOM 594 O THR A 80 -0.674 -5.158 22.406 1.00 59.90 O \\\\nATOM 595 CG2 THR A 80 -4.223 -7.497 22.877 1.00 59.90 C \\\\nATOM 596 OG1 THR A 80 -3.398 -6.369 20.967 1.00 59.90 O \\\\nATOM 597 N CYS A 81 -1.736 -3.200 22.677 1.00 47.74 N \\\\nATOM 598 CA CYS A 81 -0.661 -2.323 22.214 1.00 47.74 C \\\\nATOM 599 C CYS A 81 0.280 -1.863 23.350 1.00 47.74 C \\\\nATOM 600 CB CYS A 81 -1.319 -1.126 21.503 1.00 47.74 C \\\\nATOM 601 O CYS A 81 1.355 -1.333 23.082 1.00 47.74 O \\\\nATOM 602 SG CYS A 81 -0.392 -0.705 20.001 1.00 47.74 S \\\\nATOM 603 N SER A 82 -0.104 -2.063 24.615 1.00 37.47 N \\\\nATOM 604 CA SER A 82 0.460 -1.334 25.764 1.00 37.47 C \\\\nATOM 605 C SER A 82 1.840 -1.773 26.281 1.00 37.47 C \\\\nATOM 606 CB SER A 82 -0.560 -1.324 26.906 1.00 37.47 C \\\\nATOM 607 O SER A 82 2.295 -1.221 27.273 1.00 37.47 O \\\\nATOM 608 OG SER A 82 -1.732 -0.678 26.466 1.00 37.47 O \\\\nATOM 609 N GLU A 83 2.556 -2.707 25.645 1.00 31.77 N \\\\nATOM 610 CA GLU A 83 3.882 -3.150 26.139 1.00 31.77 C \\\\nATOM 611 C GLU A 83 5.094 -2.591 25.370 1.00 31.77 C \\\\nATOM 612 CB GLU A 83 3.915 -4.680 26.315 1.00 31.77 C \\\\nATOM 613 O GLU A 83 6.224 -2.919 25.710 1.00 31.77 O \\\\nATOM 614 CG GLU A 83 3.294 -5.082 27.666 1.00 31.77 C \\\\nATOM 615 CD GLU A 83 3.256 -6.598 27.899 1.00 31.77 C \\\\nATOM 616 OE1 GLU A 83 2.828 -7.025 29.001 1.00 31.77 O \\\\nATOM 617 OE2 GLU A 83 3.452 -7.382 26.936 1.00 31.77 O \\\\nATOM 618 N ILE A 84 4.906 -1.712 24.376 1.00 36.42 N \\\\nATOM 619 CA ILE A 84 6.024 -1.180 23.555 1.00 36.42 C \\\\nATOM 620 C ILE A 84 6.279 0.324 23.782 1.00 36.42 C \\\\nATOM 621 CB ILE A 84 5.843 -1.596 22.072 1.00 36.42 C \\\\nATOM 622 O ILE A 84 7.289 0.856 23.338 1.00 36.42 O \\\\nATOM 623 CG1 ILE A 84 5.726 -3.139 21.977 1.00 36.42 C \\\\nATOM 624 CG2 ILE A 84 6.992 -1.116 21.162 1.00 36.42 C \\\\nATOM 625 CD1 ILE A 84 5.420 -3.649 20.568 1.00 36.42 C \\\\nATOM 626 N TRP A 85 5.426 1.014 24.546 1.00 34.71 N \\\\nATOM 627 CA TRP A 85 5.549 2.464 24.793 1.00 34.71 C \\\\nATOM 628 C TRP A 85 5.761 2.828 26.271 1.00 34.71 C \\\\nATOM 629 CB TRP A 85 4.381 3.188 24.113 1.00 34.71 C \\\\nATOM 630 O TRP A 85 5.601 3.981 26.669 1.00 34.71 O \\\\nATOM 631 CG TRP A 85 4.342 2.970 22.629 1.00 34.71 C \\\\nATOM 632 CD1 TRP A 85 3.536 2.101 21.977 1.00 34.71 C \\\\nATOM 633 CD2 TRP A 85 5.203 3.561 21.607 1.00 34.71 C \\\\nATOM 634 CE2 TRP A 85 4.849 3.004 20.342 1.00 34.71 C \\\\nATOM 635 CE3 TRP A 85 6.259 4.499 21.624 1.00 34.71 C \\\\nATOM 636 NE1 TRP A 85 3.833 2.116 20.628 1.00 34.71 N \\\\nATOM 637 CH2 TRP A 85 6.542 4.307 19.203 1.00 34.71 C \\\\nATOM 638 CZ2 TRP A 85 5.500 3.365 19.152 1.00 34.71 C \\\\nATOM 639 CZ3 TRP A 85 6.920 4.870 20.436 1.00 34.71 C \\\\nATOM 640 N GLY A 86 6.149 1.843 27.086 1.00 29.44 N \\\\nATOM 641 CA GLY A 86 6.509 2.026 28.486 1.00 29.44 C \\\\nATOM 642 C GLY A 86 7.871 2.694 28.626 1.00 29.44 C \\\\nATOM 643 O GLY A 86 8.901 2.051 28.456 1.00 29.44 O \\\\nATOM 644 N LEU A 87 7.829 3.989 28.932 1.00 30.48 N \\\\nATOM 645 CA LEU A 87 8.833 4.761 29.663 1.00 30.48 C \\\\nATOM 646 C LEU A 87 9.878 3.875 30.357 1.00 30.48 C \\\\nATOM 647 CB LEU A 87 8.064 5.590 30.711 1.00 30.48 C \\\\nATOM 648 O LEU A 87 9.633 3.302 31.418 1.00 30.48 O \\\\nATOM 649 CG LEU A 87 7.241 6.738 30.097 1.00 30.48 C \\\\nATOM 650 CD1 LEU A 87 6.038 7.073 30.977 1.00 30.48 C \\\\nATOM 651 CD2 LEU A 87 8.101 7.992 29.942 1.00 30.48 C \\\\nATOM 652 N SER A 88 11.063 3.814 29.760 1.00 25.22 N \\\\nATOM 653 CA SER A 88 12.293 3.451 30.440 1.00 25.22 C \\\\nATOM 654 C SER A 88 12.496 4.428 31.599 1.00 25.22 C \\\\nATOM 655 CB SER A 88 13.476 3.470 29.450 1.00 25.22 C \\\\nATOM 656 O SER A 88 12.966 5.549 31.422 1.00 25.22 O \\\\nATOM 657 OG SER A 88 13.191 4.184 28.252 1.00 25.22 O \\\\nATOM 658 N THR A 89 12.136 4.009 32.810 1.00 30.16 N \\\\nATOM 659 CA THR A 89 12.752 4.561 34.014 1.00 30.16 C \\\\nATOM 660 C THR A 89 14.230 4.167 33.984 1.00 30.16 C \\\\nATOM 661 CB THR A 89 12.091 4.035 35.295 1.00 30.16 C \\\\nATOM 662 O THR A 89 14.527 2.970 33.921 1.00 30.16 O \\\\nATOM 663 CG2 THR A 89 10.757 4.732 35.552 1.00 30.16 C \\\\nATOM 664 OG1 THR A 89 11.841 2.651 35.201 1.00 30.16 O \\\\nATOM 665 N PRO A 90 15.173 5.124 34.002 1.00 28.90 N \\\\nATOM 666 CA PRO A 90 16.584 4.803 34.088 1.00 28.90 C \\\\nATOM 667 C PRO A 90 16.835 4.377 35.529 1.00 28.90 C \\\\nATOM 668 CB PRO A 90 17.313 6.095 33.707 1.00 28.90 C \\\\nATOM 669 O PRO A 90 16.705 5.202 36.424 1.00 28.90 O \\\\nATOM 670 CG PRO A 90 16.362 7.203 34.168 1.00 28.90 C \\\\nATOM 671 CD PRO A 90 14.973 6.563 34.105 1.00 28.90 C \\\\nATOM 672 N ASN A 91 17.056 3.084 35.752 1.00 29.36 N \\\\nATOM 673 CA ASN A 91 17.805 2.494 36.867 1.00 29.36 C \\\\nATOM 674 C ASN A 91 17.425 1.019 36.949 1.00 29.36 C \\\\nATOM 675 CB ASN A 91 17.552 3.179 38.232 1.00 29.36 C \\\\nATOM 676 O ASN A 91 16.373 0.683 37.484 1.00 29.36 O \\\\nATOM 677 CG ASN A 91 18.396 4.431 38.428 1.00 29.36 C \\\\nATOM 678 ND2 ASN A 91 18.022 5.292 39.346 1.00 29.36 N \\\\nATOM 679 OD1 ASN A 91 19.401 4.654 37.771 1.00 29.36 O \\\\nATOM 680 N THR A 92 18.254 0.164 36.353 1.00 32.37 N \\\\nATOM 681 CA THR A 92 18.830 -1.072 36.920 1.00 32.37 C \\\\nATOM 682 C THR A 92 19.379 -1.865 35.730 1.00 32.37 C \\\\nATOM 683 CB THR A 92 17.909 -1.961 37.789 1.00 32.37 C \\\\nATOM 684 O THR A 92 18.694 -2.679 35.117 1.00 32.37 O \\\\nATOM 685 CG2 THR A 92 18.737 -3.005 38.536 1.00 32.37 C \\\\nATOM 686 OG1 THR A 92 17.303 -1.246 38.836 1.00 32.37 O \\\\nATOM 687 N ILE A 93 20.615 -1.541 35.349 1.00 28.03 N \\\\nATOM 688 CA ILE A 93 21.522 -2.503 34.722 1.00 28.03 C \\\\nATOM 689 C ILE A 93 21.924 -3.445 35.857 1.00 28.03 C \\\\nATOM 690 CB ILE A 93 22.731 -1.736 34.106 1.00 28.03 C \\\\nATOM 691 O ILE A 93 22.379 -2.948 36.879 1.00 28.03 O \\\\nATOM 692 CG1 ILE A 93 22.439 -1.434 32.620 1.00 28.03 C \\\\nATOM 693 CG2 ILE A 93 24.089 -2.445 34.256 1.00 28.03 C \\\\nATOM 694 CD1 ILE A 93 23.420 -0.446 31.969 1.00 28.03 C \\\\nATOM 695 N ASP A 94 21.669 -4.747 35.726 1.00 28.87 N \\\\nATOM 696 CA ASP A 94 22.699 -5.776 35.917 1.00 28.87 C \\\\nATOM 697 C ASP A 94 22.152 -7.210 35.825 1.00 28.87 C \\\\nATOM 698 CB ASP A 94 23.527 -5.601 37.216 1.00 28.87 C \\\\nATOM 699 O ASP A 94 21.021 -7.503 36.202 1.00 28.87 O \\\\nATOM 700 CG ASP A 94 24.797 -4.765 36.982 1.00 28.87 C \\\\nATOM 701 OD1 ASP A 94 25.372 -4.904 35.874 1.00 28.87 O \\\\nATOM 702 OD2 ASP A 94 25.229 -4.050 37.912 1.00 28.87 O \\\\nATOM 703 N GLN A 95 23.048 -8.084 35.356 1.00 28.34 N \\\\nATOM 704 CA GLN A 95 23.051 -9.550 35.431 1.00 28.34 C \\\\nATOM 705 C GLN A 95 22.244 -10.349 34.398 1.00 28.34 C \\\\nATOM 706 CB GLN A 95 22.909 -10.039 36.878 1.00 28.34 C \\\\nATOM 707 O GLN A 95 21.122 -10.808 34.592 1.00 28.34 O \\\\nATOM 708 CG GLN A 95 24.224 -9.778 37.628 1.00 28.34 C \\\\nATOM 709 CD GLN A 95 24.151 -10.082 39.115 1.00 28.34 C \\\\nATOM 710 NE2 GLN A 95 25.259 -9.974 39.813 1.00 28.34 N \\\\nATOM 711 OE1 GLN A 95 23.125 -10.391 39.695 1.00 28.34 O \\\\nATOM 712 N TRP A 96 22.942 -10.621 33.298 1.00 28.28 N \\\\nATOM 713 CA TRP A 96 22.775 -11.798 32.453 1.00 28.28 C \\\\nATOM 714 C TRP A 96 23.284 -13.016 33.228 1.00 28.28 C \\\\nATOM 715 CB TRP A 96 23.558 -11.586 31.132 1.00 28.28 C \\\\nATOM 716 O TRP A 96 24.493 -13.222 33.312 1.00 28.28 O \\\\nATOM 717 CG TRP A 96 24.418 -10.350 31.070 1.00 28.28 C \\\\nATOM 718 CD1 TRP A 96 23.944 -9.116 30.787 1.00 28.28 C \\\\nATOM 719 CD2 TRP A 96 25.832 -10.165 31.407 1.00 28.28 C \\\\nATOM 720 CE2 TRP A 96 26.137 -8.773 31.296 1.00 28.28 C \\\\nATOM 721 CE3 TRP A 96 26.882 -11.012 31.826 1.00 28.28 C \\\\nATOM 722 NE1 TRP A 96 24.950 -8.184 30.923 1.00 28.28 N \\\\nATOM 723 CH2 TRP A 96 28.435 -9.124 31.956 1.00 28.28 C \\\\nATOM 724 CZ2 TRP A 96 27.409 -8.249 31.563 1.00 28.28 C \\\\nATOM 725 CZ3 TRP A 96 28.169 -10.499 32.089 1.00 28.28 C \\\\nATOM 726 N ASP A 97 22.372 -13.816 33.783 1.00 30.80 N \\\\nATOM 727 CA ASP A 97 22.724 -15.109 34.364 1.00 30.80 C \\\\nATOM 728 C ASP A 97 22.295 -16.277 33.477 1.00 30.80 C \\\\nATOM 729 CB ASP A 97 22.293 -15.250 35.836 1.00 30.80 C \\\\nATOM 730 O ASP A 97 21.179 -16.376 32.964 1.00 30.80 O \\\\nATOM 731 CG ASP A 97 23.484 -15.319 36.808 1.00 30.80 C \\\\nATOM 732 OD1 ASP A 97 24.590 -15.712 36.366 1.00 30.80 O \\\\nATOM 733 OD2 ASP A 97 23.262 -15.039 38.003 1.00 30.80 O \\\\nATOM 734 N THR A 98 23.271 -17.153 33.269 1.00 31.38 N \\\\nATOM 735 CA THR A 98 23.314 -18.206 32.260 1.00 31.38 C \\\\nATOM 736 C THR A 98 22.985 -19.534 32.926 1.00 31.38 C \\\\nATOM 737 CB THR A 98 24.722 -18.229 31.618 1.00 31.38 C \\\\nATOM 738 O THR A 98 23.879 -20.339 33.113 1.00 31.38 O \\\\nATOM 739 CG2 THR A 98 24.846 -19.152 30.402 1.00 31.38 C \\\\nATOM 740 OG1 THR A 98 25.071 -16.945 31.158 1.00 31.38 O \\\\nATOM 741 N THR A 99 21.741 -19.796 33.338 1.00 33.23 N \\\\nATOM 742 CA THR A 99 21.313 -21.157 33.728 1.00 33.23 C \\\\nATOM 743 C THR A 99 19.787 -21.311 33.746 1.00 33.23 C \\\\nATOM 744 CB THR A 99 21.846 -21.623 35.107 1.00 33.23 C \\\\nATOM 745 O THR A 99 19.082 -20.562 34.402 1.00 33.23 O \\\\nATOM 746 CG2 THR A 99 23.257 -22.219 35.127 1.00 33.23 C \\\\nATOM 747 OG1 THR A 99 21.824 -20.599 36.064 1.00 33.23 O \\\\nATOM 748 N GLY A 100 19.296 -22.335 33.041 1.00 27.30 N \\\\nATOM 749 CA GLY A 100 18.237 -23.241 33.502 1.00 27.30 C \\\\nATOM 750 C GLY A 100 16.857 -22.696 33.906 1.00 27.30 C \\\\nATOM 751 O GLY A 100 16.671 -22.157 34.986 1.00 27.30 O \\\\nATOM 752 N LEU A 101 15.853 -23.125 33.132 1.00 27.46 N \\\\nATOM 753 CA LEU A 101 14.538 -23.565 33.627 1.00 27.46 C \\\\nATOM 754 C LEU A 101 13.613 -22.492 34.228 1.00 27.46 C \\\\nATOM 755 CB LEU A 101 14.733 -24.746 34.612 1.00 27.46 C \\\\nATOM 756 O LEU A 101 13.380 -22.483 35.428 1.00 27.46 O \\\\nATOM 757 CG LEU A 101 15.334 -26.022 34.005 1.00 27.46 C \\\\nATOM 758 CD1 LEU A 101 15.954 -26.888 35.100 1.00 27.46 C \\\\nATOM 759 CD2 LEU A 101 14.255 -26.838 33.290 1.00 27.46 C \\\\nATOM 760 N TYR A 102 12.916 -21.736 33.373 1.00 30.22 N \\\\nATOM 761 CA TYR A 102 11.531 -21.351 33.669 1.00 30.22 C \\\\nATOM 762 C TYR A 102 10.646 -21.485 32.430 1.00 30.22 C \\\\nATOM 763 CB TYR A 102 11.414 -19.976 34.345 1.00 30.22 C \\\\nATOM 764 O TYR A 102 10.863 -20.877 31.385 1.00 30.22 O \\\\nATOM 765 CG TYR A 102 11.474 -20.073 35.861 1.00 30.22 C \\\\nATOM 766 CD1 TYR A 102 10.316 -20.404 36.597 1.00 30.22 C \\\\nATOM 767 CD2 TYR A 102 12.702 -19.909 36.528 1.00 30.22 C \\\\nATOM 768 CE1 TYR A 102 10.395 -20.584 37.993 1.00 30.22 C \\\\nATOM 769 CE2 TYR A 102 12.789 -20.106 37.919 1.00 30.22 C \\\\nATOM 770 OH TYR A 102 11.715 -20.639 39.995 1.00 30.22 O \\\\nATOM 771 CZ TYR A 102 11.635 -20.446 38.653 1.00 30.22 C \\\\nATOM 772 N SER A 103 9.636 -22.332 32.579 1.00 24.84 N \\\\nATOM 773 CA SER A 103 8.519 -22.529 31.672 1.00 24.84 C \\\\nATOM 774 C SER A 103 7.653 -21.269 31.646 1.00 24.84 C \\\\nATOM 775 CB SER A 103 7.727 -23.752 32.167 1.00 24.84 C \\\\nATOM 776 O SER A 103 6.948 -20.964 32.604 1.00 24.84 O \\\\nATOM 777 OG SER A 103 7.608 -23.765 33.584 1.00 24.84 O \\\\nATOM 778 N PHE A 104 7.684 -20.532 30.536 1.00 27.44 N \\\\nATOM 779 CA PHE A 104 6.739 -19.449 30.283 1.00 27.44 C \\\\nATOM 780 C PHE A 104 5.822 -19.864 29.138 1.00 27.44 C \\\\nATOM 781 CB PHE A 104 7.459 -18.110 30.061 1.00 27.44 C \\\\nATOM 782 O PHE A 104 6.258 -20.127 28.023 1.00 27.44 O \\\\nATOM 783 CG PHE A 104 6.856 -16.986 30.884 1.00 27.44 C \\\\nATOM 784 CD1 PHE A 104 5.896 -16.119 30.327 1.00 27.44 C \\\\nATOM 785 CD2 PHE A 104 7.246 -16.822 32.227 1.00 27.44 C \\\\nATOM 786 CE1 PHE A 104 5.346 -15.083 31.105 1.00 27.44 C \\\\nATOM 787 CE2 PHE A 104 6.696 -15.788 33.004 1.00 27.44 C \\\\nATOM 788 CZ PHE A 104 5.749 -14.915 32.443 1.00 27.44 C \\\\nATOM 789 N SER A 105 4.533 -19.978 29.442 1.00 27.30 N \\\\nATOM 790 CA SER A 105 3.481 -20.297 28.485 1.00 27.30 C \\\\nATOM 791 C SER A 105 3.463 -19.278 27.338 1.00 27.30 C \\\\nATOM 792 CB SER A 105 2.141 -20.303 29.231 1.00 27.30 C \\\\nATOM 793 O SER A 105 3.019 -18.142 27.521 1.00 27.30 O \\\\nATOM 794 OG SER A 105 1.982 -19.098 29.958 1.00 27.30 O \\\\nATOM 795 N GLU A 106 3.917 -19.692 26.156 1.00 25.42 N \\\\nATOM 796 CA GLU A 106 3.860 -18.921 24.914 1.00 25.42 C \\\\nATOM 797 C GLU A 106 2.403 -18.745 24.448 1.00 25.42 C \\\\nATOM 798 CB GLU A 106 4.702 -19.607 23.823 1.00 25.42 C \\\\nATOM 799 O GLU A 106 1.842 -19.550 23.706 1.00 25.42 O \\\\nATOM 800 CG GLU A 106 6.214 -19.418 24.009 1.00 25.42 C \\\\nATOM 801 CD GLU A 106 7.009 -20.112 22.892 1.00 25.42 C \\\\nATOM 802 OE1 GLU A 106 7.955 -19.480 22.375 1.00 25.42 O \\\\nATOM 803 OE2 GLU A 106 6.631 -21.253 22.542 1.00 25.42 O \\\\nATOM 804 N GLN A 107 1.765 -17.653 24.872 1.00 28.28 N \\\\nATOM 805 CA GLN A 107 0.642 -17.059 24.146 1.00 28.28 C \\\\nATOM 806 C GLN A 107 1.187 -15.917 23.290 1.00 28.28 C \\\\nATOM 807 CB GLN A 107 -0.488 -16.621 25.098 1.00 28.28 C \\\\nATOM 808 O GLN A 107 1.437 -14.817 23.774 1.00 28.28 O \\\\nATOM 809 CG GLN A 107 -1.620 -17.657 25.091 1.00 28.28 C \\\\nATOM 810 CD GLN A 107 -2.763 -17.340 26.051 1.00 28.28 C \\\\nATOM 811 NE2 GLN A 107 -3.799 -18.150 26.062 1.00 28.28 N \\\\nATOM 812 OE1 GLN A 107 -2.782 -16.380 26.803 1.00 28.28 O \\\\nATOM 813 N THR A 108 1.370 -16.198 22.003 1.00 28.45 N \\\\nATOM 814 CA THR A 108 1.763 -15.256 20.948 1.00 28.45 C \\\\nATOM 815 C THR A 108 0.865 -14.004 20.952 1.00 28.45 C \\\\nATOM 816 CB THR A 108 1.719 -15.973 19.575 1.00 28.45 C \\\\nATOM 817 O THR A 108 -0.259 -14.024 20.446 1.00 28.45 O \\\\nATOM 818 CG2 THR A 108 3.096 -16.467 19.142 1.00 28.45 C \\\\nATOM 819 OG1 THR A 108 0.905 -17.134 19.580 1.00 28.45 O \\\\nATOM 820 N ARG A 109 1.351 -12.899 21.542 1.00 34.15 N \\\\nATOM 821 CA ARG A 109 0.684 -11.581 21.578 1.00 34.15 C \\\\nATOM 822 C ARG A 109 0.880 -10.832 20.252 1.00 34.15 C \\\\nATOM 823 CB ARG A 109 1.190 -10.740 22.773 1.00 34.15 C \\\\nATOM 824 O ARG A 109 1.962 -10.830 19.675 1.00 34.15 O \\\\nATOM 825 CG ARG A 109 0.662 -11.219 24.138 1.00 34.15 C \\\\nATOM 826 CD ARG A 109 1.170 -10.320 25.277 1.00 34.15 C \\\\nATOM 827 NE ARG A 109 0.667 -10.750 26.600 1.00 34.15 N \\\\nATOM 828 NH1 ARG A 109 1.439 -8.933 27.757 1.00 34.15 N \\\\nATOM 829 NH2 ARG A 109 0.374 -10.503 28.864 1.00 34.15 N \\\\nATOM 830 CZ ARG A 109 0.826 -10.067 27.724 1.00 34.15 C \\\\nATOM 831 N SER A 110 -0.182 -10.209 19.747 1.00 40.36 N \\\\nATOM 832 CA SER A 110 -0.188 -9.347 18.556 1.00 40.36 C \\\\nATOM 833 C SER A 110 0.285 -7.932 18.902 1.00 40.36 C \\\\nATOM 834 CB SER A 110 -1.599 -9.285 17.940 1.00 40.36 C \\\\nATOM 835 O SER A 110 -0.391 -7.226 19.647 1.00 40.36 O \\\\nATOM 836 OG SER A 110 -2.593 -9.587 18.901 1.00 40.36 O \\\\nATOM 837 N LEU A 111 1.410 -7.521 18.308 1.00 46.85 N \\\\nATOM 838 CA LEU A 111 2.098 -6.232 18.510 1.00 46.85 C \\\\nATOM 839 C LEU A 111 1.354 -5.012 17.914 1.00 46.85 C \\\\nATOM 840 CB LEU A 111 3.521 -6.342 17.906 1.00 46.85 C \\\\nATOM 841 O LEU A 111 1.835 -3.891 18.007 1.00 46.85 O \\\\nATOM 842 CG LEU A 111 4.412 -7.471 18.467 1.00 46.85 C \\\\nATOM 843 CD1 LEU A 111 5.636 -7.678 17.575 1.00 46.85 C \\\\nATOM 844 CD2 LEU A 111 4.914 -7.198 19.881 1.00 46.85 C \\\\nATOM 845 N ASP A 112 0.196 -5.213 17.281 1.00 55.73 N \\\\nATOM 846 CA ASP A 112 -0.514 -4.217 16.466 1.00 55.73 C \\\\nATOM 847 C ASP A 112 -1.930 -3.883 16.980 1.00 55.73 C \\\\nATOM 848 CB ASP A 112 -0.510 -4.692 15.001 1.00 55.73 C \\\\nATOM 849 O ASP A 112 -2.784 -3.407 16.231 1.00 55.73 O \\\\nATOM 850 CG ASP A 112 -1.314 -5.975 14.740 1.00 55.73 C \\\\nATOM 851 OD1 ASP A 112 -1.678 -6.702 15.700 1.00 55.73 O \\\\nATOM 852 OD2 ASP A 112 -1.580 -6.257 13.548 1.00 55.73 O \\\\nATOM 853 N GLY A 113 -2.224 -4.171 18.253 1.00 59.81 N \\\\nATOM 854 CA GLY A 113 -3.535 -3.895 18.857 1.00 59.81 C \\\\nATOM 855 C GLY A 113 -4.675 -4.818 18.389 1.00 59.81 C \\\\nATOM 856 O GLY A 113 -5.836 -4.599 18.750 1.00 59.81 O \\\\nATOM 857 N ARG A 114 -4.391 -5.854 17.582 1.00 63.47 N \\\\nATOM 858 CA ARG A 114 -5.409 -6.800 17.093 1.00 63.47 C \\\\nATOM 859 C ARG A 114 -5.798 -7.824 18.152 1.00 63.47 C \\\\nATOM 860 CB ARG A 114 -4.942 -7.495 15.809 1.00 63.47 C \\\\nATOM 861 O ARG A 114 -4.953 -8.455 18.775 1.00 63.47 O \\\\nATOM 862 CG ARG A 114 -4.841 -6.507 14.643 1.00 63.47 C \\\\nATOM 863 CD ARG A 114 -4.440 -7.238 13.362 1.00 63.47 C \\\\nATOM 864 NE ARG A 114 -4.171 -6.273 12.286 1.00 63.47 N \\\\nATOM 865 NH1 ARG A 114 -3.462 -7.784 10.712 1.00 63.47 N \\\\nATOM 866 NH2 ARG A 114 -3.261 -5.593 10.321 1.00 63.47 N \\\\nATOM 867 CZ ARG A 114 -3.634 -6.555 11.116 1.00 63.47 C \\\\nATOM 868 N LEU A 115 -7.096 -8.079 18.277 1.00 74.63 N \\\\nATOM 869 CA LEU A 115 -7.659 -9.174 19.058 1.00 74.63 C \\\\nATOM 870 C LEU A 115 -7.690 -10.461 18.228 1.00 74.63 C \\\\nATOM 871 CB LEU A 115 -9.063 -8.754 19.520 1.00 74.63 C \\\\nATOM 872 O LEU A 115 -8.206 -10.474 17.111 1.00 74.63 O \\\\nATOM 873 CG LEU A 115 -9.828 -9.795 20.351 1.00 74.63 C \\\\nATOM 874 CD1 LEU A 115 -9.130 -10.049 21.690 1.00 74.63 C \\\\nATOM 875 CD2 LEU A 115 -11.243 -9.286 20.637 1.00 74.63 C \\\\nATOM 876 N GLN A 116 -7.198 -11.560 18.799 1.00 75.91 N \\\\nATOM 877 CA GLN A 116 -7.332 -12.890 18.211 1.00 75.91 C \\\\nATOM 878 C GLN A 116 -8.573 -13.606 18.758 1.00 75.91 C \\\\nATOM 879 CB GLN A 116 -6.034 -13.680 18.419 1.00 75.91 C \\\\nATOM 880 O GLN A 116 -8.695 -13.840 19.961 1.00 75.91 O \\\\nATOM 881 CG GLN A 116 -6.031 -15.028 17.672 1.00 75.91 C \\\\nATOM 882 CD GLN A 116 -4.640 -15.661 17.623 1.00 75.91 C \\\\nATOM 883 NE2 GLN A 116 -4.521 -16.957 17.437 1.00 75.91 N \\\\nATOM 884 OE1 GLN A 116 -3.625 -14.996 17.701 1.00 75.91 O \\\\nATOM 885 N VAL A 117 -9.483 -13.994 17.865 1.00 72.04 N \\\\nATOM 886 CA VAL A 117 -10.655 -14.827 18.167 1.00 72.04 C \\\\nATOM 887 C VAL A 117 -10.622 -16.049 17.256 1.00 72.04 C \\\\nATOM 888 CB VAL A 117 -11.978 -14.051 17.996 1.00 72.04 C \\\\nATOM 889 O VAL A 117 -10.773 -15.928 16.043 1.00 72.04 O \\\\nATOM 890 CG1 VAL A 117 -13.165 -14.936 18.402 1.00 72.04 C \\\\nATOM 891 CG2 VAL A 117 -12.019 -12.777 18.849 1.00 72.04 C \\\\nATOM 892 N SER A 118 -10.434 -17.240 17.837 1.00 68.99 N \\\\nATOM 893 CA SER A 118 -10.448 -18.525 17.114 1.00 68.99 C \\\\nATOM 894 C SER A 118 -9.568 -18.523 15.851 1.00 68.99 C \\\\nATOM 895 CB SER A 118 -11.902 -18.925 16.820 1.00 68.99 C \\\\nATOM 896 O SER A 118 -10.045 -18.857 14.771 1.00 68.99 O \\\\nATOM 897 OG SER A 118 -12.005 -20.289 16.448 1.00 68.99 O \\\\nATOM 898 N HIS A 119 -8.298 -18.123 15.997 1.00 68.93 N \\\\nATOM 899 CA HIS A 119 -7.280 -17.992 14.933 1.00 68.93 C \\\\nATOM 900 C HIS A 119 -7.458 -16.828 13.945 1.00 68.93 C \\\\nATOM 901 CB HIS A 119 -7.038 -19.332 14.213 1.00 68.93 C \\\\nATOM 902 O HIS A 119 -6.550 -16.568 13.163 1.00 68.93 O \\\\nATOM 903 CG HIS A 119 -6.783 -20.471 15.161 1.00 68.93 C \\\\nATOM 904 CD2 HIS A 119 -7.722 -21.318 15.683 1.00 68.93 C \\\\nATOM 905 ND1 HIS A 119 -5.566 -20.833 15.692 1.00 68.93 N \\\\nATOM 906 CE1 HIS A 119 -5.772 -21.870 16.522 1.00 68.93 C \\\\nATOM 907 NE2 HIS A 119 -7.079 -22.174 16.576 1.00 68.93 N \\\\nATOM 908 N ARG A 120 -8.551 -16.058 14.018 1.00 73.52 N \\\\nATOM 909 CA ARG A 120 -8.704 -14.816 13.243 1.00 73.52 C \\\\nATOM 910 C ARG A 120 -8.238 -13.621 14.072 1.00 73.52 C \\\\nATOM 911 CB ARG A 120 -10.150 -14.654 12.750 1.00 73.52 C \\\\nATOM 912 O ARG A 120 -8.711 -13.441 15.194 1.00 73.52 O \\\\nATOM 913 CG ARG A 120 -10.598 -15.814 11.841 1.00 73.52 C \\\\nATOM 914 CD ARG A 120 -11.986 -15.551 11.237 1.00 73.52 C \\\\nATOM 915 NE ARG A 120 -12.393 -16.616 10.296 1.00 73.52 N \\\\nATOM 916 NH1 ARG A 120 -14.515 -15.835 9.841 1.00 73.52 N \\\\nATOM 917 NH2 ARG A 120 -13.766 -17.643 8.785 1.00 73.52 N \\\\nATOM 918 CZ ARG A 120 -13.550 -16.692 9.650 1.00 73.52 C \\\\nATOM 919 N LYS A 121 -7.316 -12.819 13.535 1.00 76.82 N \\\\nATOM 920 CA LYS A 121 -6.859 -11.555 14.138 1.00 76.82 C \\\\nATOM 921 C LYS A 121 -7.628 -10.391 13.514 1.00 76.82 C \\\\nATOM 922 CB LYS A 121 -5.338 -11.376 13.963 1.00 76.82 C \\\\nATOM 923 O LYS A 121 -7.679 -10.288 12.295 1.00 76.82 O \\\\nATOM 924 CG LYS A 121 -4.515 -12.378 14.792 1.00 76.82 C \\\\nATOM 925 CD LYS A 121 -3.003 -12.124 14.659 1.00 76.82 C \\\\nATOM 926 CE LYS A 121 -2.218 -13.100 15.552 1.00 76.82 C \\\\nATOM 927 NZ LYS A 121 -0.748 -12.887 15.486 1.00 76.82 N \\\\nATOM 928 N GLY A 122 -8.187 -9.507 14.332 1.00 81.47 N \\\\nATOM 929 CA GLY A 122 -8.886 -8.310 13.863 1.00 81.47 C \\\\nATOM 930 C GLY A 122 -8.894 -7.214 14.919 1.00 81.47 C \\\\nATOM 931 O GLY A 122 -8.692 -7.476 16.103 1.00 81.47 O \\\\nATOM 932 N LEU A 123 -9.103 -5.968 14.505 1.00 87.81 N \\\\nATOM 933 CA LEU A 123 -9.176 -4.849 15.442 1.00 87.81 C \\\\nATOM 934 C LEU A 123 -10.486 -4.927 16.247 1.00 87.81 C \\\\nATOM 935 CB LEU A 123 -9.035 -3.529 14.676 1.00 87.81 C \\\\nATOM 936 O LEU A 123 -11.540 -5.149 15.648 1.00 87.81 O \\\\nATOM 937 CG LEU A 123 -7.629 -3.315 14.083 1.00 87.81 C \\\\nATOM 938 CD1 LEU A 123 -7.642 -2.128 13.128 1.00 87.81 C \\\\nATOM 939 CD2 LEU A 123 -6.585 -3.067 15.172 1.00 87.81 C \\\\nATOM 940 N PRO A 124 -10.460 -4.748 17.583 1.00 91.18 N \\\\nATOM 941 CA PRO A 124 -11.645 -4.955 18.413 1.00 91.18 C \\\\nATOM 942 C PRO A 124 -12.867 -4.149 17.976 1.00 91.18 C \\\\nATOM 943 CB PRO A 124 -11.227 -4.558 19.825 1.00 91.18 C \\\\nATOM 944 O PRO A 124 -13.944 -4.708 17.804 1.00 91.18 O \\\\nATOM 945 CG PRO A 124 -9.724 -4.812 19.848 1.00 91.18 C \\\\nATOM 946 CD PRO A 124 -9.285 -4.515 18.417 1.00 91.18 C \\\\nATOM 947 N HIS A 125 -12.693 -2.846 17.760 1.00 92.35 N \\\\nATOM 948 CA HIS A 125 -13.778 -1.954 17.364 1.00 92.35 C \\\\nATOM 949 C HIS A 125 -14.386 -2.352 16.009 1.00 92.35 C \\\\nATOM 950 CB HIS A 125 -13.265 -0.512 17.371 1.00 92.35 C \\\\nATOM 951 O HIS A 125 -15.605 -2.341 15.875 1.00 92.35 O \\\\nATOM 952 CG HIS A 125 -12.171 -0.245 16.372 1.00 92.35 C \\\\nATOM 953 CD2 HIS A 125 -12.325 0.383 15.167 1.00 92.35 C \\\\nATOM 954 ND1 HIS A 125 -10.841 -0.590 16.492 1.00 92.35 N \\\\nATOM 955 CE1 HIS A 125 -10.216 -0.192 15.373 1.00 92.35 C \\\\nATOM 956 NE2 HIS A 125 -11.081 0.391 14.540 1.00 92.35 N \\\\nATOM 957 N VAL A 126 -13.568 -2.806 15.049 1.00 92.28 N \\\\nATOM 958 CA VAL A 126 -14.039 -3.320 13.750 1.00 92.28 C \\\\nATOM 959 C VAL A 126 -14.865 -4.590 13.928 1.00 92.28 C \\\\nATOM 960 CB VAL A 126 -12.871 -3.598 12.784 1.00 92.28 C \\\\nATOM 961 O VAL A 126 -15.959 -4.678 13.385 1.00 92.28 O \\\\nATOM 962 CG1 VAL A 126 -13.341 -4.074 11.404 1.00 92.28 C \\\\nATOM 963 CG2 VAL A 126 -12.036 -2.341 12.566 1.00 92.28 C \\\\nATOM 964 N ILE A 127 -14.385 -5.556 14.724 1.00 92.20 N \\\\nATOM 965 CA ILE A 127 -15.093 -6.826 14.975 1.00 92.20 C \\\\nATOM 966 C ILE A 127 -16.507 -6.566 15.506 1.00 92.20 C \\\\nATOM 967 CB ILE A 127 -14.283 -7.710 15.959 1.00 92.20 C \\\\nATOM 968 O ILE A 127 -17.475 -7.159 15.032 1.00 92.20 O \\\\nATOM 969 CG1 ILE A 127 -13.002 -8.244 15.276 1.00 92.20 C \\\\nATOM 970 CG2 ILE A 127 -15.144 -8.865 16.517 1.00 92.20 C \\\\nATOM 971 CD1 ILE A 127 -11.991 -8.869 16.249 1.00 92.20 C \\\\nATOM 972 N TYR A 128 -16.629 -5.678 16.490 1.00 94.45 N \\\\nATOM 973 CA TYR A 128 -17.897 -5.428 17.169 1.00 94.45 C \\\\nATOM 974 C TYR A 128 -18.826 -4.489 16.387 1.00 94.45 C \\\\nATOM 975 CB TYR A 128 -17.579 -4.936 18.580 1.00 94.45 C \\\\nATOM 976 O TYR A 128 -20.036 -4.712 16.376 1.00 94.45 O \\\\nATOM 977 CG TYR A 128 -16.888 -5.987 19.446 1.00 94.45 C \\\\nATOM 978 CD1 TYR A 128 -17.417 -7.286 19.612 1.00 94.45 C \\\\nATOM 979 CD2 TYR A 128 -15.647 -5.676 20.023 1.00 94.45 C \\\\nATOM 980 CE1 TYR A 128 -16.688 -8.263 20.326 1.00 94.45 C \\\\nATOM 981 CE2 TYR A 128 -14.923 -6.631 20.751 1.00 94.45 C \\\\nATOM 982 OH TYR A 128 -14.702 -8.853 21.570 1.00 94.45 O \\\\nATOM 983 CZ TYR A 128 -15.439 -7.932 20.894 1.00 94.45 C \\\\nATOM 984 N CYS A 129 -18.287 -3.513 15.647 1.00 94.84 N \\\\nATOM 985 CA CYS A 129 -19.075 -2.754 14.671 1.00 94.84 C \\\\nATOM 986 C CYS A 129 -19.608 -3.661 13.555 1.00 94.84 C \\\\nATOM 987 CB CYS A 129 -18.240 -1.615 14.078 1.00 94.84 C \\\\nATOM 988 O CYS A 129 -20.777 -3.539 13.185 1.00 94.84 O \\\\nATOM 989 SG CYS A 129 -17.923 -0.349 15.334 1.00 94.84 S \\\\nATOM 990 N ARG A 130 -18.794 -4.612 13.071 1.00 93.45 N \\\\nATOM 991 CA ARG A 130 -19.218 -5.591 12.064 1.00 93.45 C \\\\nATOM 992 C ARG A 130 -20.382 -6.446 12.561 1.00 93.45 C \\\\nATOM 993 CB ARG A 130 -18.024 -6.446 11.593 1.00 93.45 C \\\\nATOM 994 O ARG A 130 -21.346 -6.669 11.841 1.00 93.45 O \\\\nATOM 995 CG ARG A 130 -18.402 -7.345 10.401 1.00 93.45 C \\\\nATOM 996 CD ARG A 130 -17.297 -8.325 9.987 1.00 93.45 C \\\\nATOM 997 NE ARG A 130 -16.140 -7.643 9.388 1.00 93.45 N \\\\nATOM 998 NH1 ARG A 130 -14.894 -9.481 8.823 1.00 93.45 N \\\\nATOM 999 NH2 ARG A 130 -14.164 -7.456 8.280 1.00 93.45 N \\\\nATOM 1000 CZ ARG A 130 -15.073 -8.194 8.841 1.00 93.45 C \\\\nATOM 1001 N LEU A 131 -20.314 -6.886 13.817 1.00 93.42 N \\\\nATOM 1002 CA LEU A 131 -21.314 -7.774 14.406 1.00 93.42 C \\\\nATOM 1003 C LEU A 131 -22.680 -7.088 14.596 1.00 93.42 C \\\\nATOM 1004 CB LEU A 131 -20.719 -8.351 15.707 1.00 93.42 C \\\\nATOM 1005 O LEU A 131 -23.709 -7.687 14.289 1.00 93.42 O \\\\nATOM 1006 CG LEU A 131 -21.370 -9.671 16.157 1.00 93.42 C \\\\nATOM 1007 CD1 LEU A 131 -20.361 -10.540 16.910 1.00 93.42 C \\\\nATOM 1008 CD2 LEU A 131 -22.557 -9.466 17.093 1.00 93.42 C \\\\nATOM 1009 N TRP A 132 -22.702 -5.844 15.089 1.00 95.06 N \\\\nATOM 1010 CA TRP A 132 -23.948 -5.172 15.499 1.00 95.06 C \\\\nATOM 1011 C TRP A 132 -24.456 -4.081 14.555 1.00 95.06 C \\\\nATOM 1012 CB TRP A 132 -23.787 -4.636 16.926 1.00 95.06 C \\\\nATOM 1013 O TRP A 132 -25.597 -3.646 14.709 1.00 95.06 O \\\\nATOM 1014 CG TRP A 132 -23.688 -5.707 17.963 1.00 95.06 C \\\\nATOM 1015 CD1 TRP A 132 -24.630 -6.650 18.186 1.00 95.06 C \\\\nATOM 1016 CD2 TRP A 132 -22.612 -5.982 18.908 1.00 95.06 C \\\\nATOM 1017 CE2 TRP A 132 -22.962 -7.158 19.640 1.00 95.06 C \\\\nATOM 1018 CE3 TRP A 132 -21.388 -5.357 19.239 1.00 95.06 C \\\\nATOM 1019 NE1 TRP A 132 -24.209 -7.512 19.174 1.00 95.06 N \\\\nATOM 1020 CH2 TRP A 132 -20.887 -7.109 20.860 1.00 95.06 C \\\\nATOM 1021 CZ2 TRP A 132 -22.104 -7.738 20.579 1.00 95.06 C \\\\nATOM 1022 CZ3 TRP A 132 -20.553 -5.900 20.234 1.00 95.06 C \\\\nATOM 1023 N ARG A 133 -23.656 -3.624 13.585 1.00 93.80 N \\\\nATOM 1024 CA ARG A 133 -24.057 -2.527 12.688 1.00 93.80 C \\\\nATOM 1025 C ARG A 133 -23.903 -2.858 11.214 1.00 93.80 C \\\\nATOM 1026 CB ARG A 133 -23.327 -1.232 13.054 1.00 93.80 C \\\\nATOM 1027 O ARG A 133 -24.900 -2.799 10.502 1.00 93.80 O \\\\nATOM 1028 CG ARG A 133 -23.740 -0.768 14.456 1.00 93.80 C \\\\nATOM 1029 CD ARG A 133 -23.208 0.630 14.740 1.00 93.80 C \\\\nATOM 1030 NE ARG A 133 -23.885 1.638 13.906 1.00 93.80 N \\\\nATOM 1031 NH1 ARG A 133 -22.534 3.330 14.523 1.00 93.80 N \\\\nATOM 1032 NH2 ARG A 133 -24.172 3.753 13.078 1.00 93.80 N \\\\nATOM 1033 CZ ARG A 133 -23.534 2.902 13.829 1.00 93.80 C \\\\nATOM 1034 N TRP A 134 -22.698 -3.219 10.781 1.00 92.86 N \\\\nATOM 1035 CA TRP A 134 -22.355 -3.332 9.359 1.00 92.86 C \\\\nATOM 1036 C TRP A 134 -21.638 -4.658 9.065 1.00 92.86 C \\\\nATOM 1037 CB TRP A 134 -21.502 -2.122 8.961 1.00 92.86 C \\\\nATOM 1038 O TRP A 134 -20.412 -4.713 9.159 1.00 92.86 O \\\\nATOM 1039 CG TRP A 134 -22.128 -0.786 9.203 1.00 92.86 C \\\\nATOM 1040 CD1 TRP A 134 -23.200 -0.283 8.552 1.00 92.86 C \\\\nATOM 1041 CD2 TRP A 134 -21.717 0.237 10.155 1.00 92.86 C \\\\nATOM 1042 CE2 TRP A 134 -22.578 1.364 10.001 1.00 92.86 C \\\\nATOM 1043 CE3 TRP A 134 -20.693 0.326 11.122 1.00 92.86 C \\\\nATOM 1044 NE1 TRP A 134 -23.466 0.992 9.014 1.00 92.86 N \\\\nATOM 1045 CH2 TRP A 134 -21.345 2.608 11.666 1.00 92.86 C \\\\nATOM 1046 CZ2 TRP A 134 -22.397 2.543 10.734 1.00 92.86 C \\\\nATOM 1047 CZ3 TRP A 134 -20.518 1.495 11.882 1.00 92.86 C \\\\nATOM 1048 N PRO A 135 -22.366 -5.742 8.736 1.00 90.70 N \\\\nATOM 1049 CA PRO A 135 -21.776 -7.058 8.453 1.00 90.70 C \\\\nATOM 1050 C PRO A 135 -20.717 -7.044 7.344 1.00 90.70 C \\\\nATOM 1051 CB PRO A 135 -22.955 -7.949 8.049 1.00 90.70 C \\\\nATOM 1052 O PRO A 135 -19.789 -7.847 7.363 1.00 90.70 O \\\\nATOM 1053 CG PRO A 135 -24.131 -7.309 8.777 1.00 90.70 C \\\\nATOM 1054 CD PRO A 135 -23.817 -5.820 8.695 1.00 90.70 C \\\\nATOM 1055 N ASP A 136 -20.846 -6.097 6.421 1.00 86.88 N \\\\nATOM 1056 CA ASP A 136 -19.995 -5.838 5.263 1.00 86.88 C \\\\nATOM 1057 C ASP A 136 -18.812 -4.895 5.560 1.00 86.88 C \\\\nATOM 1058 CB ASP A 136 -20.896 -5.265 4.158 1.00 86.88 C \\\\nATOM 1059 O ASP A 136 -18.151 -4.428 4.642 1.00 86.88 O \\\\nATOM 1060 CG ASP A 136 -21.458 -3.882 4.516 1.00 86.88 C \\\\nATOM 1061 OD1 ASP A 136 -21.929 -3.679 5.663 1.00 86.88 O \\\\nATOM 1062 OD2 ASP A 136 -21.416 -2.979 3.656 1.00 86.88 O \\\\nATOM 1063 N LEU A 137 -18.537 -4.569 6.825 1.00 87.97 N \\\\nATOM 1064 CA LEU A 137 -17.401 -3.726 7.204 1.00 87.97 C \\\\nATOM 1065 C LEU A 137 -16.083 -4.498 7.075 1.00 87.97 C \\\\nATOM 1066 CB LEU A 137 -17.626 -3.275 8.656 1.00 87.97 C \\\\nATOM 1067 O LEU A 137 -15.883 -5.449 7.826 1.00 87.97 O \\\\nATOM 1068 CG LEU A 137 -16.543 -2.322 9.169 1.00 87.97 C \\\\nATOM 1069 CD1 LEU A 137 -16.738 -0.932 8.577 1.00 87.97 C \\\\nATOM 1070 CD2 LEU A 137 -16.615 -2.224 10.690 1.00 87.97 C \\\\nATOM 1071 N HIS A 138 -15.128 -4.080 6.248 1.00 80.97 N \\\\nATOM 1072 CA HIS A 138 -13.871 -4.808 6.009 1.00 80.97 C \\\\nATOM 1073 C HIS A 138 -12.685 -4.237 6.790 1.00 80.97 C \\\\nATOM 1074 CB HIS A 138 -13.578 -4.858 4.507 1.00 80.97 C \\\\nATOM 1075 O HIS A 138 -11.864 -4.998 7.313 1.00 80.97 O \\\\nATOM 1076 CG HIS A 138 -14.632 -5.637 3.769 1.00 80.97 C \\\\nATOM 1077 CD2 HIS A 138 -14.644 -6.985 3.527 1.00 80.97 C \\\\nATOM 1078 ND1 HIS A 138 -15.826 -5.137 3.311 1.00 80.97 N \\\\nATOM 1079 CE1 HIS A 138 -16.550 -6.158 2.830 1.00 80.97 C \\\\nATOM 1080 NE2 HIS A 138 -15.882 -7.311 2.973 1.00 80.97 N \\\\nATOM 1081 N SER A 139 -12.614 -2.912 6.917 1.00 83.17 N \\\\nATOM 1082 CA SER A 139 -11.460 -2.200 7.465 1.00 83.17 C \\\\nATOM 1083 C SER A 139 -11.837 -1.201 8.559 1.00 83.17 C \\\\nATOM 1084 CB SER A 139 -10.727 -1.495 6.323 1.00 83.17 C \\\\nATOM 1085 O SER A 139 -12.946 -0.681 8.615 1.00 83.17 O \\\\nATOM 1086 OG SER A 139 -9.516 -0.929 6.795 1.00 83.17 O \\\\nATOM 1087 N HIS A 140 -10.874 -0.881 9.425 1.00 86.11 N \\\\nATOM 1088 CA HIS A 140 -11.016 0.216 10.386 1.00 86.11 C \\\\nATOM 1089 C HIS A 140 -11.071 1.593 9.723 1.00 86.11 C \\\\nATOM 1090 CB HIS A 140 -9.873 0.183 11.399 1.00 86.11 C \\\\nATOM 1091 O HIS A 140 -11.634 2.512 10.302 1.00 86.11 O \\\\nATOM 1092 CG HIS A 140 -8.528 0.596 10.861 1.00 86.11 C \\\\nATOM 1093 CD2 HIS A 140 -7.865 1.738 11.215 1.00 86.11 C \\\\nATOM 1094 ND1 HIS A 140 -7.736 -0.065 9.944 1.00 86.11 N \\\\nATOM 1095 CE1 HIS A 140 -6.614 0.656 9.776 1.00 86.11 C \\\\nATOM 1096 NE2 HIS A 140 -6.642 1.752 10.548 1.00 86.11 N \\\\nATOM 1097 N HIS A 141 -10.518 1.731 8.516 1.00 83.95 N \\\\nATOM 1098 CA HIS A 141 -10.558 2.982 7.763 1.00 83.95 C \\\\nATOM 1099 C HIS A 141 -11.983 3.357 7.319 1.00 83.95 C \\\\nATOM 1100 CB HIS A 141 -9.626 2.852 6.557 1.00 83.95 C \\\\nATOM 1101 O HIS A 141 -12.252 4.526 7.079 1.00 83.95 O \\\\nATOM 1102 CG HIS A 141 -8.176 2.638 6.875 1.00 83.95 C \\\\nATOM 1103 CD2 HIS A 141 -7.388 1.619 6.415 1.00 83.95 C \\\\nATOM 1104 ND1 HIS A 141 -7.370 3.480 7.600 1.00 83.95 N \\\\nATOM 1105 CE1 HIS A 141 -6.130 2.966 7.596 1.00 83.95 C \\\\nATOM 1106 NE2 HIS A 141 -6.101 1.811 6.913 1.00 83.95 N \\\\nATOM 1107 N GLU A 142 -12.907 2.391 7.256 1.00 89.04 N \\\\nATOM 1108 CA GLU A 142 -14.330 2.634 6.979 1.00 89.04 C \\\\nATOM 1109 C GLU A 142 -15.081 3.182 8.203 1.00 89.04 C \\\\nATOM 1110 CB GLU A 142 -14.996 1.327 6.533 1.00 89.04 C \\\\nATOM 1111 O GLU A 142 -16.275 3.461 8.114 1.00 89.04 O \\\\nATOM 1112 CG GLU A 142 -14.534 0.776 5.184 1.00 89.04 C \\\\nATOM 1113 CD GLU A 142 -15.197 -0.587 4.961 1.00 89.04 C \\\\nATOM 1114 OE1 GLU A 142 -14.500 -1.600 5.214 1.00 89.04 O \\\\nATOM 1115 OE2 GLU A 142 -16.417 -0.627 4.667 1.00 89.04 O \\\\nATOM 1116 N LEU A 143 -14.414 3.318 9.354 1.00 92.20 N \\\\nATOM 1117 CA LEU A 143 -14.996 3.828 10.589 1.00 92.20 C \\\\nATOM 1118 C LEU A 143 -14.329 5.133 11.019 1.00 92.20 C \\\\nATOM 1119 CB LEU A 143 -14.878 2.787 11.713 1.00 92.20 C \\\\nATOM 1120 O LEU A 143 -13.109 5.228 11.135 1.00 92.20 O \\\\nATOM 1121 CG LEU A 143 -15.634 1.470 11.494 1.00 92.20 C \\\\nATOM 1122 CD1 LEU A 143 -15.407 0.591 12.728 1.00 92.20 C \\\\nATOM 1123 CD2 LEU A 143 -17.138 1.678 11.311 1.00 92.20 C \\\\nATOM 1124 N LYS A 144 -15.152 6.111 11.389 1.00 92.19 N \\\\nATOM 1125 CA LYS A 144 -14.738 7.329 12.086 1.00 92.19 C \\\\nATOM 1126 C LYS A 144 -15.326 7.324 13.491 1.00 92.19 C \\\\nATOM 1127 CB LYS A 144 -15.184 8.540 11.257 1.00 92.19 C \\\\nATOM 1128 O LYS A 144 -16.518 7.089 13.653 1.00 92.19 O \\\\nATOM 1129 CG LYS A 144 -14.603 9.851 11.803 1.00 92.19 C \\\\nATOM 1130 CD LYS A 144 -15.084 11.048 10.975 1.00 92.19 C \\\\nATOM 1131 CE LYS A 144 -14.518 12.350 11.557 1.00 92.19 C \\\\nATOM 1132 NZ LYS A 144 -15.052 13.546 10.857 1.00 92.19 N \\\\nATOM 1133 N ALA A 145 -14.516 7.560 14.518 1.00 93.48 N \\\\nATOM 1134 CA ALA A 145 -15.049 7.713 15.868 1.00 93.48 C \\\\nATOM 1135 C ALA A 145 -15.831 9.030 16.001 1.00 93.48 C \\\\nATOM 1136 CB ALA A 145 -13.917 7.608 16.883 1.00 93.48 C \\\\nATOM 1137 O ALA A 145 -15.466 10.033 15.386 1.00 93.48 O \\\\nATOM 1138 N ILE A 146 -16.892 9.026 16.808 1.00 93.88 N \\\\nATOM 1139 CA ILE A 146 -17.597 10.257 17.182 1.00 93.88 C \\\\nATOM 1140 C ILE A 146 -16.704 11.122 18.078 1.00 93.88 C \\\\nATOM 1141 CB ILE A 146 -18.961 9.968 17.849 1.00 93.88 C \\\\nATOM 1142 O ILE A 146 -15.877 10.599 18.826 1.00 93.88 O \\\\nATOM 1143 CG1 ILE A 146 -18.805 9.282 19.226 1.00 93.88 C \\\\nATOM 1144 CG2 ILE A 146 -19.859 9.172 16.883 1.00 93.88 C \\\\nATOM 1145 CD1 ILE A 146 -20.121 9.053 19.971 1.00 93.88 C \\\\nATOM 1146 N GLU A 147 -16.913 12.435 18.052 1.00 91.33 N \\\\nATOM 1147 CA GLU A 147 -16.085 13.403 18.790 1.00 91.33 C \\\\nATOM 1148 C GLU A 147 -16.111 13.177 20.310 1.00 91.33 C \\\\nATOM 1149 CB GLU A 147 -16.553 14.823 18.439 1.00 91.33 C \\\\nATOM 1150 O GLU A 147 -15.098 13.340 20.983 1.00 91.33 O \\\\nATOM 1151 CG GLU A 147 -16.354 15.112 16.940 1.00 91.33 C \\\\nATOM 1152 CD GLU A 147 -16.770 16.525 16.513 1.00 91.33 C \\\\nATOM 1153 OE1 GLU A 147 -16.509 16.831 15.328 1.00 91.33 O \\\\nATOM 1154 OE2 GLU A 147 -17.365 17.248 17.340 1.00 91.33 O \\\\nATOM 1155 N ASN A 148 -17.234 12.684 20.840 1.00 91.34 N \\\\nATOM 1156 CA ASN A 148 -17.417 12.424 22.271 1.00 91.34 C \\\\nATOM 1157 C ASN A 148 -16.788 11.098 22.750 1.00 91.34 C \\\\nATOM 1158 CB ASN A 148 -18.923 12.499 22.595 1.00 91.34 C \\\\nATOM 1159 O ASN A 148 -16.949 10.719 23.912 1.00 91.34 O \\\\nATOM 1160 CG ASN A 148 -19.535 13.868 22.344 1.00 91.34 C \\\\nATOM 1161 ND2 ASN A 148 -20.838 13.988 22.425 1.00 91.34 N \\\\nATOM 1162 OD1 ASN A 148 -18.871 14.846 22.065 1.00 91.34 O \\\\nATOM 1163 N CYS A 149 -16.116 10.339 21.876 1.00 93.59 N \\\\nATOM 1164 CA CYS A 149 -15.512 9.064 22.252 1.00 93.59 C \\\\nATOM 1165 C CYS A 149 -14.118 9.261 22.868 1.00 93.59 C \\\\nATOM 1166 CB CYS A 149 -15.482 8.123 21.045 1.00 93.59 C \\\\nATOM 1167 O CYS A 149 -13.117 9.411 22.171 1.00 93.59 O \\\\nATOM 1168 SG CYS A 149 -15.018 6.462 21.626 1.00 93.59 S \\\\nATOM 1169 N GLU A 150 -14.029 9.163 24.194 1.00 93.72 N \\\\nATOM 1170 CA GLU A 150 -12.774 9.344 24.940 1.00 93.72 C \\\\nATOM 1171 C GLU A 150 -11.730 8.236 24.711 1.00 93.72 C \\\\nATOM 1172 CB GLU A 150 -13.086 9.387 26.438 1.00 93.72 C \\\\nATOM 1173 O GLU A 150 -10.553 8.426 25.023 1.00 93.72 O \\\\nATOM 1174 CG GLU A 150 -13.967 10.569 26.859 1.00 93.72 C \\\\nATOM 1175 CD GLU A 150 -14.248 10.552 28.369 1.00 93.72 C \\\\nATOM 1176 OE1 GLU A 150 -14.711 11.592 28.878 1.00 93.72 O \\\\nATOM 1177 OE2 GLU A 150 -14.031 9.488 29.003 1.00 93.72 O \\\\nATOM 1178 N TYR A 151 -12.142 7.075 24.195 1.00 93.47 N \\\\nATOM 1179 CA TYR A 151 -11.293 5.890 23.995 1.00 93.47 C \\\\nATOM 1180 C TYR A 151 -11.321 5.414 22.538 1.00 93.47 C \\\\nATOM 1181 CB TYR A 151 -11.669 4.785 24.992 1.00 93.47 C \\\\nATOM 1182 O TYR A 151 -11.233 4.219 22.254 1.00 93.47 O \\\\nATOM 1183 CG TYR A 151 -11.472 5.166 26.442 1.00 93.47 C \\\\nATOM 1184 CD1 TYR A 151 -10.273 4.836 27.103 1.00 93.47 C \\\\nATOM 1185 CD2 TYR A 151 -12.494 5.844 27.131 1.00 93.47 C \\\\nATOM 1186 CE1 TYR A 151 -10.105 5.180 28.459 1.00 93.47 C \\\\nATOM 1187 CE2 TYR A 151 -12.315 6.225 28.472 1.00 93.47 C \\\\nATOM 1188 OH TYR A 151 -10.938 6.273 30.427 1.00 93.47 O \\\\nATOM 1189 CZ TYR A 151 -11.120 5.884 29.140 1.00 93.47 C \\\\nATOM 1190 N ALA A 152 -11.501 6.342 21.600 1.00 91.45 N \\\\nATOM 1191 CA ALA A 152 -11.484 6.039 20.179 1.00 91.45 C \\\\nATOM 1192 C ALA A 152 -10.160 5.383 19.747 1.00 91.45 C \\\\nATOM 1193 CB ALA A 152 -11.749 7.336 19.422 1.00 91.45 C \\\\nATOM 1194 O ALA A 152 -9.087 5.708 20.256 1.00 91.45 O \\\\nATOM 1195 N PHE A 153 -10.225 4.463 18.780 1.00 88.26 N \\\\nATOM 1196 CA PHE A 153 -9.057 3.704 18.316 1.00 88.26 C \\\\nATOM 1197 C PHE A 153 -7.881 4.587 17.858 1.00 88.26 C \\\\nATOM 1198 CB PHE A 153 -9.508 2.782 17.176 1.00 88.26 C \\\\nATOM 1199 O PHE A 153 -6.724 4.286 18.149 1.00 88.26 O \\\\nATOM 1200 CG PHE A 153 -8.366 2.037 16.511 1.00 88.26 C \\\\nATOM 1201 CD1 PHE A 153 -7.961 2.377 15.205 1.00 88.26 C \\\\nATOM 1202 CD2 PHE A 153 -7.685 1.024 17.212 1.00 88.26 C \\\\nATOM 1203 CE1 PHE A 153 -6.883 1.703 14.605 1.00 88.26 C \\\\nATOM 1204 CE2 PHE A 153 -6.613 0.347 16.607 1.00 88.26 C \\\\nATOM 1205 CZ PHE A 153 -6.213 0.684 15.303 1.00 88.26 C \\\\nATOM 1206 N ASN A 154 -8.167 5.704 17.189 1.00 84.98 N \\\\nATOM 1207 CA ASN A 154 -7.164 6.657 16.710 1.00 84.98 C \\\\nATOM 1208 C ASN A 154 -6.425 7.402 17.838 1.00 84.98 C \\\\nATOM 1209 CB ASN A 154 -7.825 7.648 15.730 1.00 84.98 C \\\\nATOM 1210 O ASN A 154 -5.341 7.921 17.585 1.00 84.98 O \\\\nATOM 1211 CG ASN A 154 -8.927 8.482 16.366 1.00 84.98 C \\\\nATOM 1212 ND2 ASN A 154 -9.030 9.748 16.048 1.00 84.98 N \\\\nATOM 1213 OD1 ASN A 154 -9.725 7.990 17.145 1.00 84.98 O \\\\nATOM 1214 N LEU A 155 -6.959 7.425 19.067 1.00 87.90 N \\\\nATOM 1215 CA LEU A 155 -6.299 8.036 20.228 1.00 87.90 C \\\\nATOM 1216 C LEU A 155 -5.151 7.181 20.790 1.00 87.90 C \\\\nATOM 1217 CB LEU A 155 -7.331 8.347 21.331 1.00 87.90 C \\\\nATOM 1218 O LEU A 155 -4.417 7.667 21.644 1.00 87.90 O \\\\nATOM 1219 CG LEU A 155 -8.442 9.332 20.931 1.00 87.90 C \\\\nATOM 1220 CD1 LEU A 155 -9.445 9.459 22.078 1.00 87.90 C \\\\nATOM 1221 CD2 LEU A 155 -7.894 10.724 20.616 1.00 87.90 C \\\\nATOM 1222 N LYS A 156 -4.992 5.926 20.330 1.00 83.25 N \\\\nATOM 1223 CA LYS A 156 -3.895 5.009 20.710 1.00 83.25 C \\\\nATOM 1224 C LYS A 156 -3.679 4.876 22.230 1.00 83.25 C \\\\nATOM 1225 CB LYS A 156 -2.595 5.394 19.979 1.00 83.25 C \\\\nATOM 1226 O LYS A 156 -2.548 4.755 22.690 1.00 83.25 O \\\\nATOM 1227 CG LYS A 156 -2.698 5.336 18.450 1.00 83.25 C \\\\nATOM 1228 CD LYS A 156 -1.342 5.712 17.841 1.00 83.25 C \\\\nATOM 1229 CE LYS A 156 -1.398 5.654 16.312 1.00 83.25 C \\\\nATOM 1230 NZ LYS A 156 -0.087 6.019 15.718 1.00 83.25 N \\\\nATOM 1231 N LYS A 157 -4.767 4.903 23.003 1.00 86.70 N \\\\nATOM 1232 CA LYS A 157 -4.747 4.689 24.457 1.00 86.70 C \\\\nATOM 1233 C LYS A 157 -4.578 3.207 24.801 1.00 86.70 C \\\\nATOM 1234 CB LYS A 157 -6.028 5.266 25.084 1.00 86.70 C \\\\nATOM 1235 O LYS A 157 -4.794 2.338 23.958 1.00 86.70 O \\\\nATOM 1236 CG LYS A 157 -6.087 6.797 24.984 1.00 86.70 C \\\\nATOM 1237 CD LYS A 157 -7.306 7.338 25.742 1.00 86.70 C \\\\nATOM 1238 CE LYS A 157 -7.300 8.869 25.738 1.00 86.70 C \\\\nATOM 1239 NZ LYS A 157 -8.459 9.409 26.489 1.00 86.70 N \\\\nATOM 1240 N ASP A 158 -4.286 2.931 26.072 1.00 86.03 N \\\\nATOM 1241 CA ASP A 158 -4.174 1.565 26.599 1.00 86.03 C \\\\nATOM 1242 C ASP A 158 -5.472 0.765 26.502 1.00 86.03 C \\\\nATOM 1243 CB ASP A 158 -3.732 1.605 28.067 1.00 86.03 C \\\\nATOM 1244 O ASP A 158 -5.446 -0.463 26.437 1.00 86.03 O \\\\nATOM 1245 CG ASP A 158 -2.309 2.127 28.218 1.00 86.03 C \\\\nATOM 1246 OD1 ASP A 158 -1.483 1.767 27.348 1.00 86.03 O \\\\nATOM 1247 OD2 ASP A 158 -2.084 2.884 29.182 1.00 86.03 O \\\\nATOM 1248 N GLU A 159 -6.611 1.447 26.423 1.00 90.02 N \\\\nATOM 1249 CA GLU A 159 -7.905 0.844 26.152 1.00 90.02 C \\\\nATOM 1250 C GLU A 159 -8.516 1.379 24.857 1.00 90.02 C \\\\nATOM 1251 CB GLU A 159 -8.876 1.060 27.310 1.00 90.02 C \\\\nATOM 1252 O GLU A 159 -8.314 2.531 24.473 1.00 90.02 O \\\\nATOM 1253 CG GLU A 159 -8.393 0.591 28.687 1.00 90.02 C \\\\nATOM 1254 CD GLU A 159 -9.585 0.508 29.654 1.00 90.02 C \\\\nATOM 1255 OE1 GLU A 159 -9.783 -0.580 30.240 1.00 90.02 O \\\\nATOM 1256 OE2 GLU A 159 -10.397 1.463 29.700 1.00 90.02 O \\\\nATOM 1257 N VAL A 160 -9.326 0.542 24.209 1.00 92.39 N \\\\nATOM 1258 CA VAL A 160 -10.071 0.894 22.997 1.00 92.39 C \\\\nATOM 1259 C VAL A 160 -11.570 0.743 23.224 1.00 92.39 C \\\\nATOM 1260 CB VAL A 160 -9.555 0.097 21.785 1.00 92.39 C \\\\nATOM 1261 O VAL A 160 -12.034 -0.267 23.762 1.00 92.39 O \\\\nATOM 1262 CG1 VAL A 160 -9.741 -1.423 21.908 1.00 92.39 C \\\\nATOM 1263 CG2 VAL A 160 -10.216 0.560 20.481 1.00 92.39 C \\\\nATOM 1264 N CYS A 161 -12.340 1.738 22.786 1.00 95.50 N \\\\nATOM 1265 CA CYS A 161 -13.791 1.693 22.797 1.00 95.50 C \\\\nATOM 1266 C CYS A 161 -14.298 0.686 21.760 1.00 95.50 C \\\\nATOM 1267 CB CYS A 161 -14.386 3.086 22.558 1.00 95.50 C \\\\nATOM 1268 O CYS A 161 -13.922 0.727 20.589 1.00 95.50 O \\\\nATOM 1269 SG CYS A 161 -16.167 3.003 22.908 1.00 95.50 S \\\\nATOM 1270 N VAL A 162 -15.186 -0.203 22.184 1.00 94.95 N \\\\nATOM 1271 CA VAL A 162 -15.862 -1.212 21.362 1.00 94.95 C \\\\nATOM 1272 C VAL A 162 -17.372 -0.992 21.289 1.00 94.95 C \\\\nATOM 1273 CB VAL A 162 -15.524 -2.631 21.842 1.00 94.95 C \\\\nATOM 1274 O VAL A 162 -18.089 -1.851 20.781 1.00 94.95 O \\\\nATOM 1275 CG1 VAL A 162 -14.031 -2.924 21.651 1.00 94.95 C \\\\nATOM 1276 CG2 VAL A 162 -15.898 -2.904 23.300 1.00 94.95 C \\\\nATOM 1277 N ASN A 163 -17.863 0.148 21.786 1.00 95.41 N \\\\nATOM 1278 CA ASN A 163 -19.251 0.553 21.605 1.00 95.41 C \\\\nATOM 1279 C ASN A 163 -19.493 0.835 20.110 1.00 95.41 C \\\\nATOM 1280 CB ASN A 163 -19.545 1.782 22.483 1.00 95.41 C \\\\nATOM 1281 O ASN A 163 -18.922 1.790 19.579 1.00 95.41 O \\\\nATOM 1282 CG ASN A 163 -20.991 2.243 22.403 1.00 95.41 C \\\\nATOM 1283 ND2 ASN A 163 -21.418 3.024 23.364 1.00 95.41 N \\\\nATOM 1284 OD1 ASN A 163 -21.735 1.892 21.496 1.00 95.41 O \\\\nATOM 1285 N PRO A 164 -20.333 0.052 19.411 1.00 94.93 N \\\\nATOM 1286 CA PRO A 164 -20.509 0.213 17.974 1.00 94.93 C \\\\nATOM 1287 C PRO A 164 -21.177 1.545 17.590 1.00 94.93 C \\\\nATOM 1288 CB PRO A 164 -21.316 -1.015 17.552 1.00 94.93 C \\\\nATOM 1289 O PRO A 164 -21.033 1.986 16.452 1.00 94.93 O \\\\nATOM 1290 CG PRO A 164 -22.135 -1.362 18.793 1.00 94.93 C \\\\nATOM 1291 CD PRO A 164 -21.163 -1.033 19.920 1.00 94.93 C \\\\nATOM 1292 N TYR A 165 -21.868 2.218 18.518 1.00 95.74 N \\\\nATOM 1293 CA TYR A 165 -22.497 3.531 18.306 1.00 95.74 C \\\\nATOM 1294 C TYR A 165 -21.555 4.711 18.578 1.00 95.74 C \\\\nATOM 1295 CB TYR A 165 -23.792 3.622 19.123 1.00 95.74 C \\\\nATOM 1296 O TYR A 165 -21.940 5.860 18.384 1.00 95.74 O \\\\nATOM 1297 CG TYR A 165 -24.828 2.636 18.631 1.00 95.74 C \\\\nATOM 1298 CD1 TYR A 165 -25.656 2.982 17.546 1.00 95.74 C \\\\nATOM 1299 CD2 TYR A 165 -24.897 1.347 19.187 1.00 95.74 C \\\\nATOM 1300 CE1 TYR A 165 -26.551 2.039 17.010 1.00 95.74 C \\\\nATOM 1301 CE2 TYR A 165 -25.770 0.394 18.630 1.00 95.74 C \\\\nATOM 1302 OH TYR A 165 -27.473 -0.173 17.044 1.00 95.74 O \\\\nATOM 1303 CZ TYR A 165 -26.611 0.741 17.555 1.00 95.74 C \\\\nATOM 1304 N HIS A 166 -20.311 4.438 18.983 1.00 96.55 N \\\\nATOM 1305 CA HIS A 166 -19.236 5.436 19.062 1.00 96.55 C \\\\nATOM 1306 C HIS A 166 -18.425 5.553 17.774 1.00 96.55 C \\\\nATOM 1307 CB HIS A 166 -18.339 5.141 20.265 1.00 96.55 C \\\\nATOM 1308 O HIS A 166 -17.483 6.337 17.705 1.00 96.55 O \\\\nATOM 1309 CG HIS A 166 -18.963 5.469 21.593 1.00 96.55 C \\\\nATOM 1310 CD2 HIS A 166 -20.246 5.881 21.816 1.00 96.55 C \\\\nATOM 1311 ND1 HIS A 166 -18.243 5.555 22.785 1.00 96.55 N \\\\nATOM 1312 CE1 HIS A 166 -19.104 6.056 23.681 1.00 96.55 C \\\\nATOM 1313 NE2 HIS A 166 -20.313 6.236 23.137 1.00 96.55 N \\\\nATOM 1314 N TYR A 167 -18.809 4.800 16.749 1.00 95.99 N \\\\nATOM 1315 CA TYR A 167 -18.234 4.870 15.418 1.00 95.99 C \\\\nATOM 1316 C TYR A 167 -19.323 5.244 14.415 1.00 95.99 C \\\\nATOM 1317 CB TYR A 167 -17.535 3.543 15.095 1.00 95.99 C \\\\nATOM 1318 O TYR A 167 -20.494 4.939 14.606 1.00 95.99 O \\\\nATOM 1319 CG TYR A 167 -16.391 3.227 16.045 1.00 95.99 C \\\\nATOM 1320 CD1 TYR A 167 -15.102 3.728 15.781 1.00 95.99 C \\\\nATOM 1321 CD2 TYR A 167 -16.626 2.488 17.222 1.00 95.99 C \\\\nATOM 1322 CE1 TYR A 167 -14.053 3.494 16.690 1.00 95.99 C \\\\nATOM 1323 CE2 TYR A 167 -15.583 2.263 18.142 1.00 95.99 C \\\\nATOM 1324 OH TYR A 167 -13.262 2.544 18.736 1.00 95.99 O \\\\nATOM 1325 CZ TYR A 167 -14.291 2.772 17.876 1.00 95.99 C \\\\nATOM 1326 N GLN A 168 -18.962 5.909 13.336 1.00 93.44 N \\\\nATOM 1327 CA GLN A 168 -19.802 6.190 12.182 1.00 93.44 C \\\\nATOM 1328 C GLN A 168 -19.122 5.567 10.971 1.00 93.44 C \\\\nATOM 1329 CB GLN A 168 -19.992 7.702 12.024 1.00 93.44 C \\\\nATOM 1330 O GLN A 168 -17.891 5.559 10.897 1.00 93.44 O \\\\nATOM 1331 CG GLN A 168 -20.874 8.284 13.141 1.00 93.44 C \\\\nATOM 1332 CD GLN A 168 -20.992 9.804 13.068 1.00 93.44 C \\\\nATOM 1333 NE2 GLN A 168 -21.814 10.413 13.894 1.00 93.44 N \\\\nATOM 1334 OE1 GLN A 168 -20.336 10.479 12.298 1.00 93.44 O \\\\nATOM 1335 N ARG A 169 -19.905 5.005 10.051 1.00 91.38 N \\\\nATOM 1336 CA ARG A 169 -19.352 4.515 8.793 1.00 91.38 C \\\\nATOM 1337 C ARG A 169 -18.992 5.723 7.940 1.00 91.38 C \\\\nATOM 1338 CB ARG A 169 -20.329 3.558 8.104 1.00 91.38 C \\\\nATOM 1339 O ARG A 169 -19.748 6.688 7.908 1.00 91.38 O \\\\nATOM 1340 CG ARG A 169 -19.688 2.835 6.915 1.00 91.38 C \\\\nATOM 1341 CD ARG A 169 -20.634 1.759 6.375 1.00 91.38 C \\\\nATOM 1342 NE ARG A 169 -19.942 0.894 5.407 1.00 91.38 N \\\\nATOM 1343 NH1 ARG A 169 -21.627 -0.625 5.046 1.00 91.38 N \\\\nATOM 1344 NH2 ARG A 169 -19.646 -0.939 4.109 1.00 91.38 N \\\\nATOM 1345 CZ ARG A 169 -20.411 -0.206 4.856 1.00 91.38 C \\\\nATOM 1346 N VAL A 170 -17.837 5.680 7.296 1.00 88.40 N \\\\nATOM 1347 CA VAL A 170 -17.450 6.695 6.318 1.00 88.40 C \\\\nATOM 1348 C VAL A 170 -18.362 6.528 5.104 1.00 88.40 C \\\\nATOM 1349 CB VAL A 170 -15.959 6.576 5.956 1.00 88.40 C \\\\nATOM 1350 O VAL A 170 -18.325 5.495 4.438 1.00 88.40 O \\\\nATOM 1351 CG1 VAL A 170 -15.564 7.639 4.927 1.00 88.40 C \\\\nATOM 1352 CG2 VAL A 170 -15.075 6.775 7.199 1.00 88.40 C \\\\nATOM 1353 N GLU A 171 -19.219 7.514 4.864 1.00 82.22 N \\\\nATOM 1354 CA GLU A 171 -20.124 7.540 3.715 1.00 82.22 C \\\\nATOM 1355 C GLU A 171 -19.408 8.133 2.499 1.00 82.22 C \\\\nATOM 1356 CB GLU A 171 -21.407 8.317 4.059 1.00 82.22 C \\\\nATOM 1357 O GLU A 171 -18.624 9.076 2.625 1.00 82.22 O \\\\nATOM 1358 CG GLU A 171 -22.244 7.575 5.118 1.00 82.22 C \\\\nATOM 1359 CD GLU A 171 -23.545 8.288 5.520 1.00 82.22 C \\\\nATOM 1360 OE1 GLU A 171 -24.246 7.719 6.392 1.00 82.22 O \\\\nATOM 1361 OE2 GLU A 171 -23.828 9.381 4.983 1.00 82.22 O \\\\nATOM 1362 N THR A 172 -19.669 7.580 1.313 1.00 80.03 N \\\\nATOM 1363 CA THR A 172 -19.195 8.172 0.059 1.00 80.03 C \\\\nATOM 1364 C THR A 172 -20.025 9.421 -0.233 1.00 80.03 C \\\\nATOM 1365 CB THR A 172 -19.256 7.179 -1.107 1.00 80.03 C \\\\nATOM 1366 O THR A 172 -21.246 9.310 -0.362 1.00 80.03 O \\\\nATOM 1367 CG2 THR A 172 -18.685 7.755 -2.404 1.00 80.03 C \\\\nATOM 1368 OG1 THR A 172 -18.475 6.045 -0.796 1.00 80.03 O \\\\nATOM 1369 N PRO A 173 -19.405 10.609 -0.330 1.00 80.47 N \\\\nATOM 1370 CA PRO A 173 -20.132 11.834 -0.616 1.00 80.47 C \\\\nATOM 1371 C PRO A 173 -20.764 11.762 -2.009 1.00 80.47 C \\\\nATOM 1372 CB PRO A 173 -19.098 12.954 -0.499 1.00 80.47 C \\\\nATOM 1373 O PRO A 173 -20.144 11.285 -2.960 1.00 80.47 O \\\\nATOM 1374 CG PRO A 173 -17.772 12.263 -0.826 1.00 80.47 C \\\\nATOM 1375 CD PRO A 173 -17.973 10.853 -0.292 1.00 80.47 C \\\\nATOM 1376 N VAL A 174 -21.991 12.272 -2.140 1.00 82.51 N \\\\nATOM 1377 CA VAL A 174 -22.652 12.398 -3.445 1.00 82.51 C \\\\nATOM 1378 C VAL A 174 -21.908 13.453 -4.264 1.00 82.51 C \\\\nATOM 1379 CB VAL A 174 -24.147 12.744 -3.305 1.00 82.51 C \\\\nATOM 1380 O VAL A 174 -21.784 14.602 -3.839 1.00 82.51 O \\\\nATOM 1381 CG1 VAL A 174 -24.830 12.822 -4.677 1.00 82.51 C \\\\nATOM 1382 CG2 VAL A 174 -24.885 11.685 -2.474 1.00 82.51 C \\\\nATOM 1383 N LEU A 175 -21.392 13.056 -5.426 1.00 85.88 N \\\\nATOM 1384 CA LEU A 175 -20.677 13.953 -6.333 1.00 85.88 C \\\\nATOM 1385 C LEU A 175 -21.683 14.739 -7.196 1.00 85.88 C \\\\nATOM 1386 CB LEU A 175 -19.685 13.147 -7.190 1.00 85.88 C \\\\nATOM 1387 O LEU A 175 -22.635 14.137 -7.702 1.00 85.88 O \\\\nATOM 1388 CG LEU A 175 -18.604 12.400 -6.386 1.00 85.88 C \\\\nATOM 1389 CD1 LEU A 175 -17.801 11.463 -7.283 1.00 85.88 C \\\\nATOM 1390 CD2 LEU A 175 -17.627 13.363 -5.708 1.00 85.88 C \\\\nATOM 1391 N PRO A 176 -21.506 16.062 -7.378 1.00 86.02 N \\\\nATOM 1392 CA PRO A 176 -22.392 16.857 -8.224 1.00 86.02 C \\\\nATOM 1393 C PRO A 176 -22.263 16.431 -9.698 1.00 86.02 C \\\\nATOM 1394 CB PRO A 176 -21.967 18.312 -8.009 1.00 86.02 C \\\\nATOM 1395 O PRO A 176 -21.165 16.064 -10.123 1.00 86.02 O \\\\nATOM 1396 CG PRO A 176 -20.483 18.195 -7.657 1.00 86.02 C \\\\nATOM 1397 CD PRO A 176 -20.411 16.882 -6.878 1.00 86.02 C \\\\nATOM 1398 N PRO A 177 -23.344 16.482 -10.499 1.00 87.29 N \\\\nATOM 1399 CA PRO A 177 -23.257 16.213 -11.931 1.00 87.29 C \\\\nATOM 1400 C PRO A 177 -22.373 17.251 -12.631 1.00 87.29 C \\\\nATOM 1401 CB PRO A 177 -24.697 16.255 -12.451 1.00 87.29 C \\\\nATOM 1402 O PRO A 177 -22.425 18.440 -12.314 1.00 87.29 O \\\\nATOM 1403 CG PRO A 177 -25.403 17.184 -11.463 1.00 87.29 C \\\\nATOM 1404 CD PRO A 177 -24.688 16.909 -10.139 1.00 87.29 C \\\\nATOM 1405 N VAL A 178 -21.600 16.805 -13.619 1.00 87.57 N \\\\nATOM 1406 CA VAL A 178 -20.834 17.696 -14.500 1.00 87.57 C \\\\nATOM 1407 C VAL A 178 -21.767 18.192 -15.599 1.00 87.57 C \\\\nATOM 1408 CB VAL A 178 -19.596 16.981 -15.070 1.00 87.57 C \\\\nATOM 1409 O VAL A 178 -22.409 17.384 -16.266 1.00 87.57 O \\\\nATOM 1410 CG1 VAL A 178 -18.864 17.835 -16.108 1.00 87.57 C \\\\nATOM 1411 CG2 VAL A 178 -18.600 16.666 -13.950 1.00 87.57 C \\\\nATOM 1412 N LEU A 179 -21.873 19.509 -15.769 1.00 87.79 N \\\\nATOM 1413 CA LEU A 179 -22.702 20.119 -16.808 1.00 87.79 C \\\\nATOM 1414 C LEU A 179 -21.874 20.288 -18.081 1.00 87.79 C \\\\nATOM 1415 CB LEU A 179 -23.254 21.470 -16.317 1.00 87.79 C \\\\nATOM 1416 O LEU A 179 -20.872 20.998 -18.060 1.00 87.79 O \\\\nATOM 1417 CG LEU A 179 -24.097 21.415 -15.032 1.00 87.79 C \\\\nATOM 1418 CD1 LEU A 179 -24.620 22.811 -14.697 1.00 87.79 C \\\\nATOM 1419 CD2 LEU A 179 -25.295 20.471 -15.156 1.00 87.79 C \\\\nATOM 1420 N VAL A 180 -22.289 19.647 -19.172 1.00 84.28 N \\\\nATOM 1421 CA VAL A 180 -21.601 19.720 -20.466 1.00 84.28 C \\\\nATOM 1422 C VAL A 180 -22.396 20.613 -21.422 1.00 84.28 C \\\\nATOM 1423 CB VAL A 180 -21.359 18.323 -21.065 1.00 84.28 C \\\\nATOM 1424 O VAL A 180 -23.571 20.321 -21.665 1.00 84.28 O \\\\nATOM 1425 CG1 VAL A 180 -20.531 18.447 -22.348 1.00 84.28 C \\\\nATOM 1426 CG2 VAL A 180 -20.586 17.436 -20.078 1.00 84.28 C \\\\nATOM 1427 N PRO A 181 -21.807 21.693 -21.967 1.00 78.12 N \\\\nATOM 1428 CA PRO A 181 -22.442 22.482 -23.017 1.00 78.12 C \\\\nATOM 1429 C PRO A 181 -22.627 21.643 -24.281 1.00 78.12 C \\\\nATOM 1430 CB PRO A 181 -21.519 23.687 -23.260 1.00 78.12 C \\\\nATOM 1431 O PRO A 181 -21.658 21.102 -24.813 1.00 78.12 O \\\\nATOM 1432 CG PRO A 181 -20.643 23.753 -22.010 1.00 78.12 C \\\\nATOM 1433 CD PRO A 181 -20.538 22.293 -21.584 1.00 78.12 C \\\\nATOM 1434 N ARG A 182 -23.855 21.550 -24.801 1.00 67.49 N \\\\nATOM 1435 CA ARG A 182 -24.062 21.007 -26.146 1.00 67.49 C \\\\nATOM 1436 C ARG A 182 -23.515 21.998 -27.170 1.00 67.49 C \\\\nATOM 1437 CB ARG A 182 -25.542 20.692 -26.386 1.00 67.49 C \\\\nATOM 1438 O ARG A 182 -23.953 23.146 -27.230 1.00 67.49 O \\\\nATOM 1439 CG ARG A 182 -25.978 19.452 -25.594 1.00 67.49 C \\\\nATOM 1440 CD ARG A 182 -27.438 19.144 -25.917 1.00 67.49 C \\\\nATOM 1441 NE ARG A 182 -27.885 17.885 -25.302 1.00 67.49 N \\\\nATOM 1442 NH1 ARG A 182 -30.126 18.198 -25.717 1.00 67.49 N \\\\nATOM 1443 NH2 ARG A 182 -29.440 16.332 -24.732 1.00 67.49 N \\\\nATOM 1444 CZ ARG A 182 -29.139 17.478 -25.265 1.00 67.49 C \\\\nATOM 1445 N HIS A 183 -22.548 21.562 -27.974 1.00 57.15 N \\\\nATOM 1446 CA HIS A 183 -22.051 22.350 -29.097 1.00 57.15 C \\\\nATOM 1447 C HIS A 183 -23.143 22.490 -30.162 1.00 57.15 C \\\\nATOM 1448 CB HIS A 183 -20.776 21.713 -29.680 1.00 57.15 C \\\\nATOM 1449 O HIS A 183 -23.293 21.614 -31.012 1.00 57.15 O \\\\nATOM 1450 CG HIS A 183 -19.515 22.141 -28.978 1.00 57.15 C \\\\nATOM 1451 CD2 HIS A 183 -18.673 21.359 -28.233 1.00 57.15 C \\\\nATOM 1452 ND1 HIS A 183 -18.973 23.407 -29.012 1.00 57.15 N \\\\nATOM 1453 CE1 HIS A 183 -17.836 23.388 -28.298 1.00 57.15 C \\\\nATOM 1454 NE2 HIS A 183 -17.608 22.162 -27.810 1.00 57.15 N \\\\nATOM 1455 N THR A 184 -23.876 23.605 -30.134 1.00 46.80 N \\\\nATOM 1456 CA THR A 184 -24.677 24.042 -31.286 1.00 46.80 C \\\\nATOM 1457 C THR A 184 -23.954 25.106 -32.118 1.00 46.80 C \\\\nATOM 1458 CB THR A 184 -26.113 24.462 -30.917 1.00 46.80 C \\\\nATOM 1459 O THR A 184 -24.179 25.140 -33.319 1.00 46.80 O \\\\nATOM 1460 CG2 THR A 184 -27.094 24.160 -32.053 1.00 46.80 C \\\\nATOM 1461 OG1 THR A 184 -26.596 23.744 -29.802 1.00 46.80 O \\\\nATOM 1462 N GLU A 185 -23.029 25.915 -31.574 1.00 42.59 N \\\\nATOM 1463 CA GLU A 185 -22.300 26.939 -32.355 1.00 42.59 C \\\\nATOM 1464 C GLU A 185 -20.865 27.188 -31.829 1.00 42.59 C \\\\nATOM 1465 CB GLU A 185 -23.118 28.248 -32.437 1.00 42.59 C \\\\nATOM 1466 O GLU A 185 -20.599 27.141 -30.628 1.00 42.59 O \\\\nATOM 1467 CG GLU A 185 -24.438 28.065 -33.220 1.00 42.59 C \\\\nATOM 1468 CD GLU A 185 -25.260 29.335 -33.440 1.00 42.59 C \\\\nATOM 1469 OE1 GLU A 185 -26.206 29.262 -34.258 1.00 42.59 O \\\\nATOM 1470 OE2 GLU A 185 -24.976 30.351 -32.769 1.00 42.59 O \\\\nATOM 1471 N ILE A 186 -19.920 27.403 -32.751 1.00 43.70 N \\\\nATOM 1472 CA ILE A 186 -18.473 27.564 -32.524 1.00 43.70 C \\\\nATOM 1473 C ILE A 186 -18.190 28.959 -31.940 1.00 43.70 C \\\\nATOM 1474 CB ILE A 186 -17.731 27.351 -33.876 1.00 43.70 C \\\\nATOM 1475 O ILE A 186 -18.321 29.960 -32.645 1.00 43.70 O \\\\nATOM 1476 CG1 ILE A 186 -17.917 25.903 -34.397 1.00 43.70 C \\\\nATOM 1477 CG2 ILE A 186 -16.227 27.681 -33.786 1.00 43.70 C \\\\nATOM 1478 CD1 ILE A 186 -17.621 25.743 -35.895 1.00 43.70 C \\\\nATOM 1479 N LEU A 187 -17.743 29.045 -30.682 1.00 41.65 N \\\\nATOM 1480 CA LEU A 187 -17.145 30.279 -30.164 1.00 41.65 C \\\\nATOM 1481 C LEU A 187 -15.734 30.433 -30.738 1.00 41.65 C \\\\nATOM 1482 CB LEU A 187 -17.170 30.334 -28.626 1.00 41.65 C \\\\nATOM 1483 O LEU A 187 -14.805 29.707 -30.389 1.00 41.65 O \\\\nATOM 1484 CG LEU A 187 -18.565 30.585 -28.022 1.00 41.65 C \\\\nATOM 1485 CD1 LEU A 187 -18.455 30.600 -26.497 1.00 41.65 C \\\\nATOM 1486 CD2 LEU A 187 -19.178 31.921 -28.456 1.00 41.65 C \\\\nATOM 1487 N THR A 188 -15.608 31.387 -31.655 1.00 39.88 N \\\\nATOM 1488 CA THR A 188 -14.369 31.743 -32.347 1.00 39.88 C \\\\nATOM 1489 C THR A 188 -13.667 32.847 -31.557 1.00 39.88 C \\\\nATOM 1490 CB THR A 188 -14.652 32.176 -33.805 1.00 39.88 C \\\\nATOM 1491 O THR A 188 -13.729 33.993 -31.963 1.00 39.88 O \\\\nATOM 1492 CG2 THR A 188 -13.409 32.051 -34.686 1.00 39.88 C \\\\nATOM 1493 OG1 THR A 188 -15.632 31.356 -34.407 1.00 39.88 O \\\\nATOM 1494 N GLU A 189 -13.096 32.520 -30.393 1.00 39.17 N \\\\nATOM 1495 CA GLU A 189 -12.008 33.261 -29.717 1.00 39.17 C \\\\nATOM 1496 C GLU A 189 -11.721 32.594 -28.357 1.00 39.17 C \\\\nATOM 1497 CB GLU A 189 -12.299 34.776 -29.537 1.00 39.17 C \\\\nATOM 1498 O GLU A 189 -12.476 32.743 -27.398 1.00 39.17 O \\\\nATOM 1499 CG GLU A 189 -11.503 35.615 -30.564 1.00 39.17 C \\\\nATOM 1500 CD GLU A 189 -11.864 37.112 -30.592 1.00 39.17 C \\\\nATOM 1501 OE1 GLU A 189 -11.347 37.804 -31.501 1.00 39.17 O \\\\nATOM 1502 OE2 GLU A 189 -12.600 37.578 -29.692 1.00 39.17 O \\\\nATOM 1503 N LEU A 190 -10.632 31.819 -28.274 1.00 46.02 N \\\\nATOM 1504 CA LEU A 190 -10.084 31.291 -27.019 1.00 46.02 C \\\\nATOM 1505 C LEU A 190 -8.787 32.052 -26.685 1.00 46.02 C \\\\nATOM 1506 CB LEU A 190 -9.839 29.770 -27.126 1.00 46.02 C \\\\nATOM 1507 O LEU A 190 -7.996 32.310 -27.598 1.00 46.02 O \\\\nATOM 1508 CG LEU A 190 -11.069 28.909 -26.773 1.00 46.02 C \\\\nATOM 1509 CD1 LEU A 190 -10.925 27.510 -27.372 1.00 46.02 C \\\\nATOM 1510 CD2 LEU A 190 -11.236 28.751 -25.258 1.00 46.02 C \\\\nATOM 1511 N PRO A 191 -8.544 32.405 -25.407 1.00 44.40 N \\\\nATOM 1512 CA PRO A 191 -7.281 32.997 -24.973 1.00 44.40 C \\\\nATOM 1513 C PRO A 191 -6.117 32.019 -25.213 1.00 44.40 C \\\\nATOM 1514 CB PRO A 191 -7.478 33.357 -23.496 1.00 44.40 C \\\\nATOM 1515 O PRO A 191 -6.349 30.810 -25.301 1.00 44.40 O \\\\nATOM 1516 CG PRO A 191 -8.582 32.417 -23.018 1.00 44.40 C \\\\nATOM 1517 CD PRO A 191 -9.399 32.116 -24.270 1.00 44.40 C \\\\nATOM 1518 N PRO A 192 -4.872 32.515 -25.343 1.00 44.87 N \\\\nATOM 1519 CA PRO A 192 -3.722 31.678 -25.668 1.00 44.87 C \\\\nATOM 1520 C PRO A 192 -3.588 30.547 -24.642 1.00 44.87 C \\\\nATOM 1521 CB PRO A 192 -2.510 32.619 -25.694 1.00 44.87 C \\\\nATOM 1522 O PRO A 192 -3.456 30.796 -23.446 1.00 44.87 O \\\\nATOM 1523 CG PRO A 192 -2.947 33.804 -24.832 1.00 44.87 C \\\\nATOM 1524 CD PRO A 192 -4.452 33.878 -25.071 1.00 44.87 C \\\\nATOM 1525 N LEU A 193 -3.669 29.307 -25.127 1.00 47.96 N \\\\nATOM 1526 CA LEU A 193 -3.348 28.114 -24.354 1.00 47.96 C \\\\nATOM 1527 C LEU A 193 -1.859 28.168 -24.002 1.00 47.96 C \\\\nATOM 1528 CB LEU A 193 -3.669 26.855 -25.189 1.00 47.96 C \\\\nATOM 1529 O LEU A 193 -1.025 28.289 -24.900 1.00 47.96 O \\\\nATOM 1530 CG LEU A 193 -5.169 26.516 -25.287 1.00 47.96 C \\\\nATOM 1531 CD1 LEU A 193 -5.420 25.532 -26.432 1.00 47.96 C \\\\nATOM 1532 CD2 LEU A 193 -5.678 25.874 -23.994 1.00 47.96 C \\\\nATOM 1533 N ASP A 194 -1.534 28.058 -22.714 1.00 43.48 N \\\\nATOM 1534 CA ASP A 194 -0.163 27.779 -22.297 1.00 43.48 C \\\\nATOM 1535 C ASP A 194 0.288 26.455 -22.931 1.00 43.48 C \\\\nATOM 1536 CB ASP A 194 -0.029 27.747 -20.764 1.00 43.48 C \\\\nATOM 1537 O ASP A 194 -0.447 25.463 -22.966 1.00 43.48 O \\\\nATOM 1538 CG ASP A 194 0.055 29.139 -20.120 1.00 43.48 C \\\\nATOM 1539 OD1 ASP A 194 0.655 30.045 -20.741 1.00 43.48 O \\\\nATOM 1540 OD2 ASP A 194 -0.427 29.269 -18.971 1.00 43.48 O \\\\nATOM 1541 N ASP A 195 1.502 26.463 -23.471 1.00 40.98 N \\\\nATOM 1542 CA ASP A 195 2.109 25.353 -24.193 1.00 40.98 C \\\\nATOM 1543 C ASP A 195 2.381 24.181 -23.226 1.00 40.98 C \\\\nATOM 1544 CB ASP A 195 3.357 25.896 -24.920 1.00 40.98 C \\\\nATOM 1545 O ASP A 195 3.425 24.073 -22.582 1.00 40.98 O \\\\nATOM 1546 CG ASP A 195 3.821 25.038 -26.099 1.00 40.98 C \\\\nATOM 1547 OD1 ASP A 195 3.338 23.887 -26.222 1.00 40.98 O \\\\nATOM 1548 OD2 ASP A 195 4.683 25.520 -26.864 1.00 40.98 O \\\\nATOM 1549 N TYR A 196 1.401 23.287 -23.074 1.00 45.99 N \\\\nATOM 1550 CA TYR A 196 1.498 22.073 -22.256 1.00 45.99 C \\\\nATOM 1551 C TYR A 196 2.280 20.949 -22.954 1.00 45.99 C \\\\nATOM 1552 CB TYR A 196 0.104 21.626 -21.782 1.00 45.99 C \\\\nATOM 1553 O TYR A 196 2.133 19.776 -22.601 1.00 45.99 O \\\\nATOM 1554 CG TYR A 196 -0.449 22.425 -20.621 1.00 45.99 C \\\\nATOM 1555 CD1 TYR A 196 0.004 22.188 -19.305 1.00 45.99 C \\\\nATOM 1556 CD2 TYR A 196 -1.435 23.397 -20.858 1.00 45.99 C \\\\nATOM 1557 CE1 TYR A 196 -0.532 22.927 -18.231 1.00 45.99 C \\\\nATOM 1558 CE2 TYR A 196 -1.974 24.134 -19.790 1.00 45.99 C \\\\nATOM 1559 OH TYR A 196 -2.055 24.617 -17.450 1.00 45.99 O \\\\nATOM 1560 CZ TYR A 196 -1.526 23.902 -18.477 1.00 45.99 C \\\\nATOM 1561 N THR A 197 3.168 21.259 -23.899 1.00 44.07 N \\\\nATOM 1562 CA THR A 197 4.138 20.294 -24.449 1.00 44.07 C \\\\nATOM 1563 C THR A 197 5.068 19.704 -23.373 1.00 44.07 C \\\\nATOM 1564 CB THR A 197 4.937 20.916 -25.605 1.00 44.07 C \\\\nATOM 1565 O THR A 197 5.636 18.633 -23.572 1.00 44.07 O \\\\nATOM 1566 CG2 THR A 197 4.119 20.933 -26.895 1.00 44.07 C \\\\nATOM 1567 OG1 THR A 197 5.316 22.233 -25.300 1.00 44.07 O \\\\nATOM 1568 N HIS A 198 5.111 20.292 -22.171 1.00 42.09 N \\\\nATOM 1569 CA HIS A 198 5.744 19.726 -20.969 1.00 42.09 C \\\\nATOM 1570 C HIS A 198 4.830 18.831 -20.098 1.00 42.09 C \\\\nATOM 1571 CB HIS A 198 6.354 20.877 -20.161 1.00 42.09 C \\\\nATOM 1572 O HIS A 198 5.241 18.362 -19.037 1.00 42.09 O \\\\nATOM 1573 CG HIS A 198 7.428 21.607 -20.924 1.00 42.09 C \\\\nATOM 1574 CD2 HIS A 198 7.425 22.924 -21.302 1.00 42.09 C \\\\nATOM 1575 ND1 HIS A 198 8.589 21.047 -21.409 1.00 42.09 N \\\\nATOM 1576 CE1 HIS A 198 9.273 22.005 -22.054 1.00 42.09 C \\\\nATOM 1577 NE2 HIS A 198 8.615 23.170 -21.994 1.00 42.09 N \\\\nATOM 1578 N SER A 199 3.585 18.569 -20.513 1.00 43.75 N \\\\nATOM 1579 CA SER A 199 2.611 17.784 -19.731 1.00 43.75 C \\\\nATOM 1580 C SER A 199 2.780 16.269 -19.848 1.00 43.75 C \\\\nATOM 1581 CB SER A 199 1.176 18.147 -20.110 1.00 43.75 C \\\\nATOM 1582 O SER A 199 2.189 15.538 -19.049 1.00 43.75 O \\\\nATOM 1583 OG SER A 199 0.904 17.723 -21.433 1.00 43.75 O \\\\nATOM 1584 N ILE A 200 3.559 15.781 -20.821 1.00 42.94 N \\\\nATOM 1585 CA ILE A 200 4.083 14.414 -20.812 1.00 42.94 C \\\\nATOM 1586 C ILE A 200 5.367 14.491 -20.005 1.00 42.94 C \\\\nATOM 1587 CB ILE A 200 4.378 13.862 -22.226 1.00 42.94 C \\\\nATOM 1588 O ILE A 200 6.360 15.025 -20.501 1.00 42.94 O \\\\nATOM 1589 CG1 ILE A 200 3.113 13.892 -23.105 1.00 42.94 C \\\\nATOM 1590 CG2 ILE A 200 4.921 12.419 -22.113 1.00 42.94 C \\\\nATOM 1591 CD1 ILE A 200 3.385 13.574 -24.580 1.00 42.94 C \\\\nATOM 1592 N PRO A 201 5.411 13.973 -18.773 1.00 48.89 N \\\\nATOM 1593 CA PRO A 201 6.698 13.882 -18.145 1.00 48.89 C \\\\nATOM 1594 C PRO A 201 7.513 12.838 -18.892 1.00 48.89 C \\\\nATOM 1595 CB PRO A 201 6.435 13.536 -16.703 1.00 48.89 C \\\\nATOM 1596 O PRO A 201 7.066 11.701 -19.058 1.00 48.89 O \\\\nATOM 1597 CG PRO A 201 4.922 13.301 -16.558 1.00 48.89 C \\\\nATOM 1598 CD PRO A 201 4.381 13.323 -17.983 1.00 48.89 C \\\\nATOM 1599 N GLU A 202 8.725 13.207 -19.300 1.00 54.78 N \\\\nATOM 1600 CA GLU A 202 9.679 12.321 -19.981 1.00 54.78 C \\\\nATOM 1601 C GLU A 202 9.876 10.989 -19.236 1.00 54.78 C \\\\nATOM 1602 CB GLU A 202 11.032 13.036 -20.092 1.00 54.78 C \\\\nATOM 1603 O GLU A 202 10.212 9.968 -19.833 1.00 54.78 O \\\\nATOM 1604 CG GLU A 202 11.007 14.228 -21.061 1.00 54.78 C \\\\nATOM 1605 CD GLU A 202 12.381 14.908 -21.171 1.00 54.78 C \\\\nATOM 1606 OE1 GLU A 202 12.648 15.502 -22.237 1.00 54.78 O \\\\nATOM 1607 OE2 GLU A 202 13.154 14.818 -20.188 1.00 54.78 O \\\\nATOM 1608 N ASN A 203 9.570 10.956 -17.934 1.00 64.59 N \\\\nATOM 1609 CA ASN A 203 9.573 9.748 -17.121 1.00 64.59 C \\\\nATOM 1610 C ASN A 203 8.459 8.712 -17.415 1.00 64.59 C \\\\nATOM 1611 CB ASN A 203 9.696 10.114 -15.636 1.00 64.59 C \\\\nATOM 1612 O ASN A 203 8.453 7.652 -16.776 1.00 64.59 O \\\\nATOM 1613 CG ASN A 203 8.514 10.710 -14.914 1.00 64.59 C \\\\nATOM 1614 ND2 ASN A 203 8.751 11.229 -13.733 1.00 64.59 N \\\\nATOM 1615 OD1 ASN A 203 7.370 10.626 -15.308 1.00 64.59 O \\\\nATOM 1616 N THR A 204 7.555 8.980 -18.366 1.00 56.41 N \\\\nATOM 1617 CA THR A 204 6.367 8.156 -18.675 1.00 56.41 C \\\\nATOM 1618 C THR A 204 6.367 7.475 -20.049 1.00 56.41 C \\\\nATOM 1619 CB THR A 204 5.059 8.951 -18.512 1.00 56.41 C \\\\nATOM 1620 O THR A 204 5.433 6.726 -20.332 1.00 56.41 O \\\\nATOM 1621 CG2 THR A 204 4.880 9.530 -17.113 1.00 56.41 C \\\\nATOM 1622 OG1 THR A 204 4.971 10.026 -19.414 1.00 56.41 O \\\\nATOM 1623 N ASN A 205 7.384 7.676 -20.897 1.00 49.30 N \\\\nATOM 1624 CA ASN A 205 7.339 7.163 -22.271 1.00 49.30 C \\\\nATOM 1625 C ASN A 205 7.411 5.624 -22.351 1.00 49.30 C \\\\nATOM 1626 CB ASN A 205 8.401 7.859 -23.157 1.00 49.30 C \\\\nATOM 1627 O ASN A 205 8.383 4.995 -21.919 1.00 49.30 O \\\\nATOM 1628 CG ASN A 205 7.823 8.911 -24.097 1.00 49.30 C \\\\nATOM 1629 ND2 ASN A 205 8.634 9.491 -24.948 1.00 49.30 N \\\\nATOM 1630 OD1 ASN A 205 6.647 9.226 -24.088 1.00 49.30 O \\\\nATOM 1631 N PHE A 206 6.385 5.039 -22.974 1.00 41.13 N \\\\nATOM 1632 CA PHE A 206 6.423 3.713 -23.590 1.00 41.13 C \\\\nATOM 1633 C PHE A 206 6.857 3.858 -25.057 1.00 41.13 C \\\\nATOM 1634 CB PHE A 206 5.035 3.059 -23.535 1.00 41.13 C \\\\nATOM 1635 O PHE A 206 6.550 4.880 -25.673 1.00 41.13 O \\\\nATOM 1636 CG PHE A 206 4.514 2.747 -22.147 1.00 41.13 C \\\\nATOM 1637 CD1 PHE A 206 4.761 1.489 -21.561 1.00 41.13 C \\\\nATOM 1638 CD2 PHE A 206 3.716 3.689 -21.474 1.00 41.13 C \\\\nATOM 1639 CE1 PHE A 206 4.166 1.158 -20.330 1.00 41.13 C \\\\nATOM 1640 CE2 PHE A 206 3.120 3.357 -20.247 1.00 41.13 C \\\\nATOM 1641 CZ PHE A 206 3.318 2.084 -19.694 1.00 41.13 C \\\\nATOM 1642 N PRO A 207 7.522 2.860 -25.663 1.00 35.10 N \\\\nATOM 1643 CA PRO A 207 7.728 2.862 -27.104 1.00 35.10 C \\\\nATOM 1644 C PRO A 207 6.383 2.618 -27.804 1.00 35.10 C \\\\nATOM 1645 CB PRO A 207 8.771 1.770 -27.363 1.00 35.10 C \\\\nATOM 1646 O PRO A 207 5.911 1.486 -27.892 1.00 35.10 O \\\\nATOM 1647 CG PRO A 207 8.559 0.782 -26.214 1.00 35.10 C \\\\nATOM 1648 CD PRO A 207 8.049 1.647 -25.059 1.00 35.10 C \\\\nATOM 1649 N ALA A 208 5.752 3.680 -28.303 1.00 33.84 N \\\\nATOM 1650 CA ALA A 208 4.773 3.562 -29.375 1.00 33.84 C \\\\nATOM 1651 C ALA A 208 5.554 3.220 -30.654 1.00 33.84 C \\\\nATOM 1652 CB ALA A 208 3.977 4.870 -29.479 1.00 33.84 C \\\\nATOM 1653 O ALA A 208 6.194 4.086 -31.242 1.00 33.84 O \\\\nATOM 1654 N GLY A 209 5.598 1.936 -31.016 1.00 29.29 N \\\\nATOM 1655 CA GLY A 209 6.338 1.481 -32.193 1.00 29.29 C \\\\nATOM 1656 C GLY A 209 6.670 -0.006 -32.166 1.00 29.29 C \\\\nATOM 1657 O GLY A 209 7.836 -0.376 -32.081 1.00 29.29 O \\\\nATOM 1658 N ILE A 210 5.653 -0.865 -32.237 1.00 34.22 N \\\\nATOM 1659 CA ILE A 210 5.816 -2.192 -32.838 1.00 34.22 C \\\\nATOM 1660 C ILE A 210 4.875 -2.199 -34.036 1.00 34.22 C \\\\nATOM 1661 CB ILE A 210 5.576 -3.353 -31.843 1.00 34.22 C \\\\nATOM 1662 O ILE A 210 3.655 -2.203 -33.873 1.00 34.22 O \\\\nATOM 1663 CG1 ILE A 210 6.570 -3.264 -30.660 1.00 34.22 C \\\\nATOM 1664 CG2 ILE A 210 5.729 -4.704 -32.570 1.00 34.22 C \\\\nATOM 1665 CD1 ILE A 210 6.384 -4.344 -29.585 1.00 34.22 C \\\\nATOM 1666 N GLU A 211 5.458 -2.118 -35.229 1.00 29.47 N \\\\nATOM 1667 CA GLU A 211 4.771 -2.379 -36.491 1.00 29.47 C \\\\nATOM 1668 C GLU A 211 4.011 -3.714 -36.392 1.00 29.47 C \\\\nATOM 1669 CB GLU A 211 5.802 -2.499 -37.624 1.00 29.47 C \\\\nATOM 1670 O GLU A 211 4.579 -4.702 -35.910 1.00 29.47 O \\\\nATOM 1671 CG GLU A 211 6.550 -1.198 -37.940 1.00 29.47 C \\\\nATOM 1672 CD GLU A 211 7.571 -1.409 -39.071 1.00 29.47 C \\\\nATOM 1673 OE1 GLU A 211 7.591 -0.576 -40.002 1.00 29.47 O \\\\nATOM 1674 OE2 GLU A 211 8.328 -2.405 -38.988 1.00 29.47 O \\\\nATOM 1675 N PRO A 212 2.747 -3.800 -36.837 1.00 32.98 N \\\\nATOM 1676 CA PRO A 212 2.040 -5.065 -36.836 1.00 32.98 C \\\\nATOM 1677 C PRO A 212 2.586 -5.915 -37.986 1.00 32.98 C \\\\nATOM 1678 CB PRO A 212 0.560 -4.696 -36.957 1.00 32.98 C \\\\nATOM 1679 O PRO A 212 2.143 -5.812 -39.129 1.00 32.98 O \\\\nATOM 1680 CG PRO A 212 0.579 -3.395 -37.760 1.00 32.98 C \\\\nATOM 1681 CD PRO A 212 1.919 -2.746 -37.402 1.00 32.98 C \\\\nATOM 1682 N GLN A 213 3.550 -6.788 -37.688 1.00 33.15 N \\\\nATOM 1683 CA GLN A 213 3.832 -7.926 -38.553 1.00 33.15 C \\\\nATOM 1684 C GLN A 213 2.620 -8.861 -38.511 1.00 33.15 C \\\\nATOM 1685 CB GLN A 213 5.141 -8.631 -38.170 1.00 33.15 C \\\\nATOM 1686 O GLN A 213 2.426 -9.630 -37.572 1.00 33.15 O \\\\nATOM 1687 CG GLN A 213 6.360 -7.846 -38.680 1.00 33.15 C \\\\nATOM 1688 CD GLN A 213 7.684 -8.575 -38.463 1.00 33.15 C \\\\nATOM 1689 NE2 GLN A 213 8.735 -8.163 -39.138 1.00 33.15 N \\\\nATOM 1690 OE1 GLN A 213 7.815 -9.515 -37.695 1.00 33.15 O \\\\nATOM 1691 N SER A 214 1.776 -8.698 -39.530 1.00 28.82 N \\\\nATOM 1692 CA SER A 214 0.949 -9.711 -40.183 1.00 28.82 C \\\\nATOM 1693 C SER A 214 0.850 -11.054 -39.449 1.00 28.82 C \\\\nATOM 1694 CB SER A 214 1.532 -9.943 -41.589 1.00 28.82 C \\\\nATOM 1695 O SER A 214 1.736 -11.894 -39.588 1.00 28.82 O \\\\nATOM 1696 OG SER A 214 2.881 -10.376 -41.529 1.00 28.82 O \\\\nATOM 1697 N ASN A 215 -0.261 -11.301 -38.753 1.00 34.40 N \\\\nATOM 1698 CA ASN A 215 -0.771 -12.656 -38.568 1.00 34.40 C \\\\nATOM 1699 C ASN A 215 -2.291 -12.627 -38.360 1.00 34.40 C \\\\nATOM 1700 CB ASN A 215 -0.009 -13.410 -37.457 1.00 34.40 C \\\\nATOM 1701 O ASN A 215 -2.806 -12.058 -37.404 1.00 34.40 O \\\\nATOM 1702 CG ASN A 215 1.130 -14.267 -38.005 1.00 34.40 C \\\\nATOM 1703 ND2 ASN A 215 2.151 -14.511 -37.219 1.00 34.40 N \\\\nATOM 1704 OD1 ASN A 215 1.103 -14.773 -39.116 1.00 34.40 O \\\\nATOM 1705 N TYR A 216 -2.961 -13.225 -39.344 1.00 29.75 N \\\\nATOM 1706 CA TYR A 216 -4.365 -13.598 -39.470 1.00 29.75 C \\\\nATOM 1707 C TYR A 216 -5.182 -13.675 -38.168 1.00 29.75 C \\\\nATOM 1708 CB TYR A 216 -4.356 -14.989 -40.129 1.00 29.75 C \\\\nATOM 1709 O TYR A 216 -4.917 -14.511 -37.307 1.00 29.75 O \\\\nATOM 1710 CG TYR A 216 -4.028 -14.992 -41.611 1.00 29.75 C \\\\nATOM 1711 CD1 TYR A 216 -5.088 -15.091 -42.531 1.00 29.75 C \\\\nATOM 1712 CD2 TYR A 216 -2.697 -14.914 -42.080 1.00 29.75 C \\\\nATOM 1713 CE1 TYR A 216 -4.830 -15.108 -43.913 1.00 29.75 C \\\\nATOM 1714 CE2 TYR A 216 -2.437 -14.907 -43.466 1.00 29.75 C \\\\nATOM 1715 OH TYR A 216 -3.271 -15.017 -45.721 1.00 29.75 O \\\\nATOM 1716 CZ TYR A 216 -3.507 -15.008 -44.384 1.00 29.75 C \\\\nATOM 1717 N ILE A 217 -6.277 -12.912 -38.117 1.00 36.30 N \\\\nATOM 1718 CA ILE A 217 -7.477 -13.261 -37.345 1.00 36.30 C \\\\nATOM 1719 C ILE A 217 -8.657 -13.233 -38.337 1.00 36.30 C \\\\nATOM 1720 CB ILE A 217 -7.702 -12.323 -36.136 1.00 36.30 C \\\\nATOM 1721 O ILE A 217 -8.815 -12.221 -39.022 1.00 36.30 O \\\\nATOM 1722 CG1 ILE A 217 -6.452 -12.275 -35.225 1.00 36.30 C \\\\nATOM 1723 CG2 ILE A 217 -8.930 -12.810 -35.341 1.00 36.30 C \\\\nATOM 1724 CD1 ILE A 217 -6.571 -11.314 -34.035 1.00 36.30 C \\\\nATOM 1725 N PRO A 218 -9.443 -14.318 -38.481 1.00 32.96 N \\\\nATOM 1726 CA PRO A 218 -10.608 -14.346 -39.360 1.00 32.96 C \\\\nATOM 1727 C PRO A 218 -11.803 -13.572 -38.782 1.00 32.96 C \\\\nATOM 1728 CB PRO A 218 -10.946 -15.820 -39.605 1.00 32.96 C \\\\nATOM 1729 O PRO A 218 -11.941 -13.411 -37.572 1.00 32.96 O \\\\nATOM 1730 CG PRO A 218 -10.051 -16.621 -38.658 1.00 32.96 C \\\\nATOM 1731 CD PRO A 218 -9.295 -15.598 -37.813 1.00 32.96 C \\\\nATOM 1732 N GLU A 219 -12.654 -13.127 -39.705 1.00 30.87 N \\\\nATOM 1733 CA GLU A 219 -13.843 -12.283 -39.574 1.00 30.87 C \\\\nATOM 1734 C GLU A 219 -14.855 -12.670 -38.479 1.00 30.87 C \\\\nATOM 1735 CB GLU A 219 -14.609 -12.357 -40.910 1.00 30.87 C \\\\nATOM 1736 O GLU A 219 -15.227 -13.832 -38.327 1.00 30.87 O \\\\nATOM 1737 CG GLU A 219 -13.824 -11.896 -42.144 1.00 30.87 C \\\\nATOM 1738 CD GLU A 219 -14.698 -12.002 -43.401 1.00 30.87 C \\\\nATOM 1739 OE1 GLU A 219 -14.979 -10.943 -44.004 1.00 30.87 O \\\\nATOM 1740 OE2 GLU A 219 -15.076 -13.146 -43.743 1.00 30.87 O \\\\nATOM 1741 N THR A 220 -15.441 -11.649 -37.848 1.00 36.68 N \\\\nATOM 1742 CA THR A 220 -16.836 -11.658 -37.378 1.00 36.68 C \\\\nATOM 1743 C THR A 220 -17.442 -10.258 -37.576 1.00 36.68 C \\\\nATOM 1744 CB THR A 220 -17.000 -12.083 -35.902 1.00 36.68 C \\\\nATOM 1745 O THR A 220 -16.932 -9.297 -36.999 1.00 36.68 O \\\\nATOM 1746 CG2 THR A 220 -17.311 -13.572 -35.758 1.00 36.68 C \\\\nATOM 1747 OG1 THR A 220 -15.859 -11.832 -35.113 1.00 36.68 O \\\\nATOM 1748 N PRO A 221 -18.508 -10.089 -38.385 1.00 42.32 N \\\\nATOM 1749 CA PRO A 221 -19.201 -8.809 -38.514 1.00 42.32 C \\\\nATOM 1750 C PRO A 221 -20.236 -8.633 -37.382 1.00 42.32 C \\\\nATOM 1751 CB PRO A 221 -19.847 -8.851 -39.900 1.00 42.32 C \\\\nATOM 1752 O PRO A 221 -20.784 -9.632 -36.904 1.00 42.32 O \\\\nATOM 1753 CG PRO A 221 -20.189 -10.332 -40.078 1.00 42.32 C \\\\nATOM 1754 CD PRO A 221 -19.111 -11.072 -39.279 1.00 42.32 C \\\\nATOM 1755 N PRO A 222 -20.556 -7.399 -36.941 1.00 47.76 N \\\\nATOM 1756 CA PRO A 222 -21.640 -7.176 -35.990 1.00 47.76 C \\\\nATOM 1757 C PRO A 222 -23.023 -7.337 -36.662 1.00 47.76 C \\\\nATOM 1758 CB PRO A 222 -21.442 -5.774 -35.404 1.00 47.76 C \\\\nATOM 1759 O PRO A 222 -23.148 -7.094 -37.864 1.00 47.76 O \\\\nATOM 1760 CG PRO A 222 -20.184 -5.225 -36.082 1.00 47.76 C \\\\nATOM 1761 CD PRO A 222 -19.949 -6.129 -37.291 1.00 47.76 C \\\\nATOM 1762 N PRO A 223 -24.074 -7.726 -35.913 1.00 42.45 N \\\\nATOM 1763 CA PRO A 223 -25.353 -8.184 -36.465 1.00 42.45 C \\\\nATOM 1764 C PRO A 223 -26.228 -7.049 -37.015 1.00 42.45 C \\\\nATOM 1765 CB PRO A 223 -26.073 -8.914 -35.318 1.00 42.45 C \\\\nATOM 1766 O PRO A 223 -26.425 -6.032 -36.351 1.00 42.45 O \\\\nATOM 1767 CG PRO A 223 -25.013 -9.078 -34.231 1.00 42.45 C \\\\nATOM 1768 CD PRO A 223 -24.088 -7.897 -34.472 1.00 42.45 C \\\\nATOM 1769 N GLY A 224 -26.819 -7.264 -38.195 1.00 31.26 N \\\\nATOM 1770 CA GLY A 224 -27.895 -6.433 -38.735 1.00 31.26 C \\\\nATOM 1771 C GLY A 224 -29.232 -6.735 -38.057 1.00 31.26 C \\\\nATOM 1772 O GLY A 224 -29.611 -7.898 -37.926 1.00 31.26 O \\\\nATOM 1773 N TYR A 225 -29.949 -5.687 -37.649 1.00 42.75 N \\\\nATOM 1774 CA TYR A 225 -31.335 -5.777 -37.197 1.00 42.75 C \\\\nATOM 1775 C TYR A 225 -32.252 -5.158 -38.255 1.00 42.75 C \\\\nATOM 1776 CB TYR A 225 -31.515 -5.177 -35.793 1.00 42.75 C \\\\nATOM 1777 O TYR A 225 -32.238 -3.956 -38.508 1.00 42.75 O \\\\nATOM 1778 CG TYR A 225 -32.127 -6.155 -34.804 1.00 42.75 C \\\\nATOM 1779 CD1 TYR A 225 -33.524 -6.206 -34.627 1.00 42.75 C \\\\nATOM 1780 CD2 TYR A 225 -31.296 -7.033 -34.081 1.00 42.75 C \\\\nATOM 1781 CE1 TYR A 225 -34.087 -7.112 -33.708 1.00 42.75 C \\\\nATOM 1782 CE2 TYR A 225 -31.855 -7.941 -33.160 1.00 42.75 C \\\\nATOM 1783 OH TYR A 225 -33.792 -8.853 -32.080 1.00 42.75 O \\\\nATOM 1784 CZ TYR A 225 -33.252 -7.978 -32.969 1.00 42.75 C \\\\nATOM 1785 N ILE A 226 -32.999 -6.051 -38.888 1.00 36.55 N \\\\nATOM 1786 CA ILE A 226 -34.214 -5.839 -39.670 1.00 36.55 C \\\\nATOM 1787 C ILE A 226 -35.349 -5.370 -38.745 1.00 36.55 C \\\\nATOM 1788 CB ILE A 226 -34.596 -7.182 -40.357 1.00 36.55 C \\\\nATOM 1789 O ILE A 226 -35.517 -5.922 -37.659 1.00 36.55 O \\\\nATOM 1790 CG1 ILE A 226 -34.358 -8.412 -39.430 1.00 36.55 C \\\\nATOM 1791 CG2 ILE A 226 -33.797 -7.334 -41.664 1.00 36.55 C \\\\nATOM 1792 CD1 ILE A 226 -34.952 -9.729 -39.929 1.00 36.55 C \\\\nATOM 1793 N SER A 227 -36.143 -4.400 -39.199 1.00 47.93 N \\\\nATOM 1794 CA SER A 227 -37.483 -4.130 -38.667 1.00 47.93 C \\\\nATOM 1795 C SER A 227 -38.434 -3.907 -39.840 1.00 47.93 C \\\\nATOM 1796 CB SER A 227 -37.516 -2.924 -37.725 1.00 47.93 C \\\\nATOM 1797 O SER A 227 -38.234 -2.993 -40.640 1.00 47.93 O \\\\nATOM 1798 OG SER A 227 -36.754 -3.159 -36.553 1.00 47.93 O \\\\nATOM 1799 N GLU A 228 -39.414 -4.800 -39.935 1.00 46.11 N \\\\nATOM 1800 CA GLU A 228 -40.514 -4.858 -40.896 1.00 46.11 C \\\\nATOM 1801 C GLU A 228 -41.667 -3.894 -40.525 1.00 46.11 C \\\\nATOM 1802 CB GLU A 228 -41.021 -6.321 -40.936 1.00 46.11 C \\\\nATOM 1803 O GLU A 228 -41.901 -3.624 -39.349 1.00 46.11 O \\\\nATOM 1804 CG GLU A 228 -40.045 -7.298 -41.618 1.00 46.11 C \\\\nATOM 1805 CD GLU A 228 -40.428 -8.779 -41.415 1.00 46.11 C \\\\nATOM 1806 OE1 GLU A 228 -40.687 -9.476 -42.424 1.00 46.11 O \\\\nATOM 1807 OE2 GLU A 228 -40.337 -9.242 -40.252 1.00 46.11 O \\\\nATOM 1808 N ASP A 229 -42.363 -3.439 -41.575 1.00 43.27 N \\\\nATOM 1809 CA ASP A 229 -43.800 -3.134 -41.730 1.00 43.27 C \\\\nATOM 1810 C ASP A 229 -44.535 -2.042 -40.918 1.00 43.27 C \\\\nATOM 1811 CB ASP A 229 -44.587 -4.454 -41.742 1.00 43.27 C \\\\nATOM 1812 O ASP A 229 -44.500 -1.981 -39.691 1.00 43.27 O \\\\nATOM 1813 CG ASP A 229 -44.099 -5.419 -42.832 1.00 43.27 C \\\\nATOM 1814 OD1 ASP A 229 -43.547 -4.923 -43.845 1.00 43.27 O \\\\nATOM 1815 OD2 ASP A 229 -44.293 -6.638 -42.646 1.00 43.27 O \\\\nATOM 1816 N GLY A 230 -45.339 -1.235 -41.644 1.00 41.83 N \\\\nATOM 1817 CA GLY A 230 -46.419 -0.420 -41.058 1.00 41.83 C \\\\nATOM 1818 C GLY A 230 -46.959 0.792 -41.851 1.00 41.83 C \\\\nATOM 1819 O GLY A 230 -46.917 1.899 -41.337 1.00 41.83 O \\\\nATOM 1820 N GLU A 231 -47.436 0.576 -43.083 1.00 42.15 N \\\\nATOM 1821 CA GLU A 231 -48.653 1.121 -43.747 1.00 42.15 C \\\\nATOM 1822 C GLU A 231 -49.152 2.603 -43.629 1.00 42.15 C \\\\nATOM 1823 CB GLU A 231 -49.811 0.155 -43.417 1.00 42.15 C \\\\nATOM 1824 O GLU A 231 -49.428 3.117 -42.550 1.00 42.15 O \\\\nATOM 1825 CG GLU A 231 -49.540 -1.282 -43.904 1.00 42.15 C \\\\nATOM 1826 CD GLU A 231 -50.767 -2.196 -43.772 1.00 42.15 C \\\\nATOM 1827 OE1 GLU A 231 -51.040 -2.932 -44.747 1.00 42.15 O \\\\nATOM 1828 OE2 GLU A 231 -51.429 -2.146 -42.712 1.00 42.15 O \\\\nATOM 1829 N THR A 232 -49.529 3.161 -44.808 1.00 42.91 N \\\\nATOM 1830 CA THR A 232 -50.599 4.171 -45.128 1.00 42.91 C \\\\nATOM 1831 C THR A 232 -50.304 5.675 -44.888 1.00 42.91 C \\\\nATOM 1832 CB THR A 232 -51.949 3.746 -44.514 1.00 42.91 C \\\\nATOM 1833 O THR A 232 -49.792 6.040 -43.845 1.00 42.91 O \\\\nATOM 1834 CG2 THR A 232 -52.463 2.399 -45.036 1.00 42.91 C \\\\nATOM 1835 OG1 THR A 232 -51.949 3.754 -43.110 1.00 42.91 O \\\\nATOM 1836 N SER A 233 -50.593 6.665 -45.754 1.00 42.08 N \\\\nATOM 1837 CA SER A 233 -51.392 6.803 -46.990 1.00 42.08 C \\\\nATOM 1838 C SER A 233 -50.855 7.944 -47.882 1.00 42.08 C \\\\nATOM 1839 CB SER A 233 -52.827 7.235 -46.655 1.00 42.08 C \\\\nATOM 1840 O SER A 233 -50.367 8.956 -47.382 1.00 42.08 O \\\\nATOM 1841 OG SER A 233 -53.568 6.191 -46.074 1.00 42.08 O \\\\nATOM 1842 N ASP A 234 -51.034 7.784 -49.195 1.00 37.27 N \\\\nATOM 1843 CA ASP A 234 -50.823 8.764 -50.269 1.00 37.27 C \\\\nATOM 1844 C ASP A 234 -51.973 9.792 -50.428 1.00 37.27 C \\\\nATOM 1845 CB ASP A 234 -50.708 7.975 -51.598 1.00 37.27 C \\\\nATOM 1846 O ASP A 234 -53.094 9.568 -49.971 1.00 37.27 O \\\\nATOM 1847 CG ASP A 234 -49.301 7.534 -51.967 1.00 37.27 C \\\\nATOM 1848 OD1 ASP A 234 -48.425 8.425 -51.963 1.00 37.27 O \\\\nATOM 1849 OD2 ASP A 234 -49.159 6.359 -52.367 1.00 37.27 O \\\\nATOM 1850 N GLN A 235 -51.692 10.795 -51.282 1.00 43.07 N \\\\nATOM 1851 CA GLN A 235 -52.589 11.706 -52.035 1.00 43.07 C \\\\nATOM 1852 C GLN A 235 -52.955 13.016 -51.294 1.00 43.07 C \\\\nATOM 1853 CB GLN A 235 -53.801 10.947 -52.638 1.00 43.07 C \\\\nATOM 1854 O GLN A 235 -53.390 12.989 -50.157 1.00 43.07 O \\\\nATOM 1855 CG GLN A 235 -53.418 9.621 -53.332 1.00 43.07 C \\\\nATOM 1856 CD GLN A 235 -54.524 8.941 -54.125 1.00 43.07 C \\\\nATOM 1857 NE2 GLN A 235 -54.307 7.709 -54.536 1.00 43.07 N \\\\nATOM 1858 OE1 GLN A 235 -55.570 9.491 -54.427 1.00 43.07 O \\\\nATOM 1859 N GLN A 236 -52.828 14.231 -51.848 1.00 40.77 N \\\\nATOM 1860 CA GLN A 236 -53.079 14.661 -53.225 1.00 40.77 C \\\\nATOM 1861 C GLN A 236 -52.575 16.115 -53.450 1.00 40.77 C \\\\nATOM 1862 CB GLN A 236 -54.617 14.612 -53.409 1.00 40.77 C \\\\nATOM 1863 O GLN A 236 -52.714 16.948 -52.564 1.00 40.77 O \\\\nATOM 1864 CG GLN A 236 -55.092 14.033 -54.742 1.00 40.77 C \\\\nATOM 1865 CD GLN A 236 -56.567 13.641 -54.715 1.00 40.77 C \\\\nATOM 1866 NE2 GLN A 236 -57.005 12.779 -55.602 1.00 40.77 N \\\\nATOM 1867 OE1 GLN A 236 -57.365 14.104 -53.921 1.00 40.77 O \\\\nATOM 1868 N LEU A 237 -51.998 16.353 -54.642 1.00 40.25 N \\\\nATOM 1869 CA LEU A 237 -51.968 17.543 -55.533 1.00 40.25 C \\\\nATOM 1870 C LEU A 237 -52.324 18.968 -55.019 1.00 40.25 C \\\\nATOM 1871 CB LEU A 237 -52.972 17.219 -56.665 1.00 40.25 C \\\\nATOM 1872 O LEU A 237 -53.214 19.127 -54.205 1.00 40.25 O \\\\nATOM 1873 CG LEU A 237 -52.494 16.164 -57.685 1.00 40.25 C \\\\nATOM 1874 CD1 LEU A 237 -53.184 14.814 -57.499 1.00 40.25 C \\\\nATOM 1875 CD2 LEU A 237 -52.813 16.621 -59.108 1.00 40.25 C \\\\nATOM 1876 N ASN A 238 -51.915 20.102 -55.611 1.00 38.01 N \\\\nATOM 1877 CA ASN A 238 -50.938 20.586 -56.609 1.00 38.01 C \\\\nATOM 1878 C ASN A 238 -51.364 22.056 -56.911 1.00 38.01 C \\\\nATOM 1879 CB ASN A 238 -50.998 19.776 -57.931 1.00 38.01 C \\\\nATOM 1880 O ASN A 238 -52.565 22.311 -56.914 1.00 38.01 O \\\\nATOM 1881 CG ASN A 238 -49.783 19.919 -58.827 1.00 38.01 C \\\\nATOM 1882 ND2 ASN A 238 -49.811 19.335 -60.006 1.00 38.01 N \\\\nATOM 1883 OD1 ASN A 238 -48.781 20.517 -58.487 1.00 38.01 O \\\\nATOM 1884 N GLN A 239 -50.420 22.937 -57.292 1.00 40.11 N \\\\nATOM 1885 CA GLN A 239 -50.619 24.237 -58.001 1.00 40.11 C \\\\nATOM 1886 C GLN A 239 -51.303 25.383 -57.200 1.00 40.11 C \\\\nATOM 1887 CB GLN A 239 -51.318 23.941 -59.348 1.00 40.11 C \\\\nATOM 1888 O GLN A 239 -52.139 25.132 -56.350 1.00 40.11 O \\\\nATOM 1889 CG GLN A 239 -50.440 23.130 -60.314 1.00 40.11 C \\\\nATOM 1890 CD GLN A 239 -51.238 22.565 -61.483 1.00 40.11 C \\\\nATOM 1891 NE2 GLN A 239 -51.226 21.271 -61.713 1.00 40.11 N \\\\nATOM 1892 OE1 GLN A 239 -51.873 23.269 -62.241 1.00 40.11 O \\\\nATOM 1893 N SER A 240 -51.038 26.686 -57.365 1.00 43.35 N \\\\nATOM 1894 CA SER A 240 -50.202 27.499 -58.269 1.00 43.35 C \\\\nATOM 1895 C SER A 240 -50.144 28.959 -57.738 1.00 43.35 C \\\\nATOM 1896 CB SER A 240 -50.762 27.509 -59.706 1.00 43.35 C \\\\nATOM 1897 O SER A 240 -50.901 29.325 -56.844 1.00 43.35 O \\\\nATOM 1898 OG SER A 240 -52.158 27.305 -59.748 1.00 43.35 O \\\\nATOM 1899 N MET A 241 -49.217 29.754 -58.286 1.00 42.24 N \\\\nATOM 1900 CA MET A 241 -48.848 31.152 -57.975 1.00 42.24 C \\\\nATOM 1901 C MET A 241 -49.996 32.180 -58.075 1.00 42.24 C \\\\nATOM 1902 CB MET A 241 -47.796 31.564 -59.029 1.00 42.24 C \\\\nATOM 1903 O MET A 241 -50.863 32.002 -58.918 1.00 42.24 O \\\\nATOM 1904 CG MET A 241 -46.510 30.723 -59.019 1.00 42.24 C \\\\nATOM 1905 SD MET A 241 -45.467 30.947 -60.489 1.00 42.24 S \\\\nATOM 1906 CE MET A 241 -44.030 29.949 -60.015 1.00 42.24 C \\\\nATOM 1907 N ASP A 242 -49.936 33.283 -57.305 1.00 40.97 N \\\\nATOM 1908 CA ASP A 242 -49.971 34.649 -57.871 1.00 40.97 C \\\\nATOM 1909 C ASP A 242 -49.706 35.794 -56.863 1.00 40.97 C \\\\nATOM 1910 CB ASP A 242 -51.237 34.953 -58.711 1.00 40.97 C \\\\nATOM 1911 O ASP A 242 -49.965 35.727 -55.664 1.00 40.97 O \\\\nATOM 1912 CG ASP A 242 -51.029 34.730 -60.222 1.00 40.97 C \\\\nATOM 1913 OD1 ASP A 242 -49.864 34.851 -60.676 1.00 40.97 O \\\\nATOM 1914 OD2 ASP A 242 -52.042 34.530 -60.928 1.00 40.97 O \\\\nATOM 1915 N THR A 243 -49.128 36.839 -57.450 1.00 38.70 N \\\\nATOM 1916 CA THR A 243 -48.641 38.169 -57.038 1.00 38.70 C \\\\nATOM 1917 C THR A 243 -49.545 39.095 -56.201 1.00 38.70 C \\\\nATOM 1918 CB THR A 243 -48.421 38.931 -58.366 1.00 38.70 C \\\\nATOM 1919 O THR A 243 -50.746 39.164 -56.437 1.00 38.70 O \\\\nATOM 1920 CG2 THR A 243 -47.054 38.660 -58.985 1.00 38.70 C \\\\nATOM 1921 OG1 THR A 243 -49.362 38.545 -59.348 1.00 38.70 O \\\\nATOM 1922 N GLY A 244 -48.926 39.973 -55.383 1.00 39.50 N \\\\nATOM 1923 CA GLY A 244 -49.496 41.283 -54.995 1.00 39.50 C \\\\nATOM 1924 C GLY A 244 -49.025 41.882 -53.651 1.00 39.50 C \\\\nATOM 1925 O GLY A 244 -49.585 41.568 -52.609 1.00 39.50 O \\\\nATOM 1926 N SER A 245 -48.027 42.774 -53.675 1.00 42.65 N \\\\nATOM 1927 CA SER A 245 -47.559 43.641 -52.560 1.00 42.65 C \\\\nATOM 1928 C SER A 245 -48.484 44.872 -52.339 1.00 42.65 C \\\\nATOM 1929 CB SER A 245 -46.157 44.149 -52.950 1.00 42.65 C \\\\nATOM 1930 O SER A 245 -49.369 45.087 -53.164 1.00 42.65 O \\\\nATOM 1931 OG SER A 245 -45.287 43.109 -53.350 1.00 42.65 O \\\\nATOM 1932 N PRO A 246 -48.160 45.856 -51.462 1.00 43.21 N \\\\nATOM 1933 CA PRO A 246 -47.896 45.842 -50.010 1.00 43.21 C \\\\nATOM 1934 C PRO A 246 -48.722 46.921 -49.241 1.00 43.21 C \\\\nATOM 1935 CB PRO A 246 -46.411 46.213 -49.915 1.00 43.21 C \\\\nATOM 1936 O PRO A 246 -49.145 47.911 -49.832 1.00 43.21 O \\\\nATOM 1937 CG PRO A 246 -46.212 47.195 -51.082 1.00 43.21 C \\\\nATOM 1938 CD PRO A 246 -47.416 46.984 -52.009 1.00 43.21 C \\\\nATOM 1939 N ALA A 247 -48.870 46.811 -47.911 1.00 43.57 N \\\\nATOM 1940 CA ALA A 247 -49.324 47.925 -47.059 1.00 43.57 C \\\\nATOM 1941 C ALA A 247 -48.847 47.812 -45.588 1.00 43.57 C \\\\nATOM 1942 CB ALA A 247 -50.855 48.047 -47.127 1.00 43.57 C \\\\nATOM 1943 O ALA A 247 -49.112 46.824 -44.914 1.00 43.57 O \\\\nATOM 1944 N GLU A 248 -48.155 48.869 -45.145 1.00 39.39 N \\\\nATOM 1945 CA GLU A 248 -48.252 49.554 -43.837 1.00 39.39 C \\\\nATOM 1946 C GLU A 248 -47.778 48.893 -42.512 1.00 39.39 C \\\\nATOM 1947 CB GLU A 248 -49.618 50.255 -43.728 1.00 39.39 C \\\\nATOM 1948 O GLU A 248 -48.478 48.144 -41.844 1.00 39.39 O \\\\nATOM 1949 CG GLU A 248 -49.804 51.247 -44.896 1.00 39.39 C \\\\nATOM 1950 CD GLU A 248 -51.023 52.160 -44.732 1.00 39.39 C \\\\nATOM 1951 OE1 GLU A 248 -50.856 53.370 -45.004 1.00 39.39 O \\\\nATOM 1952 OE2 GLU A 248 -52.101 51.647 -44.362 1.00 39.39 O \\\\nATOM 1953 N LEU A 249 -46.569 49.313 -42.100 1.00 41.33 N \\\\nATOM 1954 CA LEU A 249 -46.170 49.896 -40.798 1.00 41.33 C \\\\nATOM 1955 C LEU A 249 -46.823 49.398 -39.486 1.00 41.33 C \\\\nATOM 1956 CB LEU A 249 -46.370 51.429 -40.891 1.00 41.33 C \\\\nATOM 1957 O LEU A 249 -47.955 49.752 -39.176 1.00 41.33 O \\\\nATOM 1958 CG LEU A 249 -45.467 52.162 -41.899 1.00 41.33 C \\\\nATOM 1959 CD1 LEU A 249 -46.013 53.561 -42.181 1.00 41.33 C \\\\nATOM 1960 CD2 LEU A 249 -44.037 52.303 -41.372 1.00 41.33 C \\\\nATOM 1961 N SER A 250 -46.004 48.805 -38.602 1.00 40.23 N \\\\nATOM 1962 CA SER A 250 -45.986 49.060 -37.140 1.00 40.23 C \\\\nATOM 1963 C SER A 250 -44.722 48.453 -36.493 1.00 40.23 C \\\\nATOM 1964 CB SER A 250 -47.207 48.455 -36.435 1.00 40.23 C \\\\nATOM 1965 O SER A 250 -44.469 47.267 -36.697 1.00 40.23 O \\\\nATOM 1966 OG SER A 250 -48.333 49.282 -36.627 1.00 40.23 O \\\\nATOM 1967 N PRO A 251 -43.913 49.201 -35.712 1.00 37.55 N \\\\nATOM 1968 CA PRO A 251 -42.774 48.652 -34.979 1.00 37.55 C \\\\nATOM 1969 C PRO A 251 -43.180 48.301 -33.541 1.00 37.55 C \\\\nATOM 1970 CB PRO A 251 -41.722 49.764 -35.026 1.00 37.55 C \\\\nATOM 1971 O PRO A 251 -43.771 49.122 -32.841 1.00 37.55 O \\\\nATOM 1972 CG PRO A 251 -42.560 51.046 -34.979 1.00 37.55 C \\\\nATOM 1973 CD PRO A 251 -43.921 50.653 -35.571 1.00 37.55 C \\\\nATOM 1974 N THR A 252 -42.853 47.104 -33.053 1.00 40.99 N \\\\nATOM 1975 CA THR A 252 -42.973 46.801 -31.617 1.00 40.99 C \\\\nATOM 1976 C THR A 252 -41.962 45.744 -31.171 1.00 40.99 C \\\\nATOM 1977 CB THR A 252 -44.410 46.432 -31.164 1.00 40.99 C \\\\nATOM 1978 O THR A 252 -42.014 44.586 -31.566 1.00 40.99 O \\\\nATOM 1979 CG2 THR A 252 -44.923 47.403 -30.096 1.00 40.99 C \\\\nATOM 1980 OG1 THR A 252 -45.352 46.526 -32.205 1.00 40.99 O \\\\nATOM 1981 N THR A 253 -41.062 46.204 -30.295 1.00 40.72 N \\\\nATOM 1982 CA THR A 253 -40.430 45.482 -29.175 1.00 40.72 C \\\\nATOM 1983 C THR A 253 -39.524 44.280 -29.471 1.00 40.72 C \\\\nATOM 1984 CB THR A 253 -41.461 45.163 -28.079 1.00 40.72 C \\\\nATOM 1985 O THR A 253 -39.961 43.140 -29.593 1.00 40.72 O \\\\nATOM 1986 CG2 THR A 253 -41.946 46.453 -27.410 1.00 40.72 C \\\\nATOM 1987 OG1 THR A 253 -42.597 44.519 -28.600 1.00 40.72 O \\\\nATOM 1988 N LEU A 254 -38.216 44.561 -29.424 1.00 39.36 N \\\\nATOM 1989 CA LEU A 254 -37.133 43.610 -29.166 1.00 39.36 C \\\\nATOM 1990 C LEU A 254 -37.409 42.817 -27.876 1.00 39.36 C \\\\nATOM 1991 CB LEU A 254 -35.824 44.415 -29.003 1.00 39.36 C \\\\nATOM 1992 O LEU A 254 -37.460 43.395 -26.791 1.00 39.36 O \\\\nATOM 1993 CG LEU A 254 -35.280 45.017 -30.315 1.00 39.36 C \\\\nATOM 1994 CD1 LEU A 254 -34.831 46.466 -30.117 1.00 39.36 C \\\\nATOM 1995 CD2 LEU A 254 -34.086 44.210 -30.824 1.00 39.36 C \\\\nATOM 1996 N SER A 255 -37.551 41.499 -28.001 1.00 41.25 N \\\\nATOM 1997 CA SER A 255 -37.453 40.555 -26.882 1.00 41.25 C \\\\nATOM 1998 C SER A 255 -36.006 40.052 -26.797 1.00 41.25 C \\\\nATOM 1999 CB SER A 255 -38.413 39.381 -27.082 1.00 41.25 C \\\\nATOM 2000 O SER A 255 -35.414 39.783 -27.845 1.00 41.25 O \\\\nATOM 2001 OG SER A 255 -39.740 39.860 -27.175 1.00 41.25 O \\\\nATOM 2002 N PRO A 256 -35.403 39.934 -25.602 1.00 41.93 N \\\\nATOM 2003 CA PRO A 256 -34.027 39.477 -25.476 1.00 41.93 C \\\\nATOM 2004 C PRO A 256 -33.949 37.988 -25.824 1.00 41.93 C \\\\nATOM 2005 CB PRO A 256 -33.620 39.791 -24.034 1.00 41.93 C \\\\nATOM 2006 O PRO A 256 -34.719 37.173 -25.314 1.00 41.93 O \\\\nATOM 2007 CG PRO A 256 -34.942 39.739 -23.267 1.00 41.93 C \\\\nATOM 2008 CD PRO A 256 -35.998 40.152 -24.294 1.00 41.93 C \\\\nATOM 2009 N VAL A 257 -33.012 37.640 -26.704 1.00 38.71 N \\\\nATOM 2010 CA VAL A 257 -32.677 36.258 -27.054 1.00 38.71 C \\\\nATOM 2011 C VAL A 257 -32.097 35.594 -25.803 1.00 38.71 C \\\\nATOM 2012 CB VAL A 257 -31.690 36.217 -28.246 1.00 38.71 C \\\\nATOM 2013 O VAL A 257 -30.939 35.808 -25.450 1.00 38.71 O \\\\nATOM 2014 CG1 VAL A 257 -31.494 34.785 -28.757 1.00 38.71 C \\\\nATOM 2015 CG2 VAL A 257 -32.192 37.068 -29.424 1.00 38.71 C \\\\nATOM 2016 N ASN A 258 -32.916 34.816 -25.092 1.00 38.20 N \\\\nATOM 2017 CA ASN A 258 -32.433 33.894 -24.070 1.00 38.20 C \\\\nATOM 2018 C ASN A 258 -31.664 32.778 -24.786 1.00 38.20 C \\\\nATOM 2019 CB ASN A 258 -33.611 33.347 -23.225 1.00 38.20 C \\\\nATOM 2020 O ASN A 258 -32.248 31.774 -25.190 1.00 38.20 O \\\\nATOM 2021 CG ASN A 258 -33.801 34.022 -21.876 1.00 38.20 C \\\\nATOM 2022 ND2 ASN A 258 -34.835 33.652 -21.157 1.00 38.20 N \\\\nATOM 2023 OD1 ASN A 258 -33.028 34.845 -21.420 1.00 38.20 O \\\\nATOM 2024 N HIS A 259 -30.350 32.941 -24.936 1.00 43.97 N \\\\nATOM 2025 CA HIS A 259 -29.453 31.814 -25.172 1.00 43.97 C \\\\nATOM 2026 C HIS A 259 -29.431 30.956 -23.899 1.00 43.97 C \\\\nATOM 2027 CB HIS A 259 -28.052 32.306 -25.574 1.00 43.97 C \\\\nATOM 2028 O HIS A 259 -28.532 31.072 -23.068 1.00 43.97 O \\\\nATOM 2029 CG HIS A 259 -27.983 32.894 -26.961 1.00 43.97 C \\\\nATOM 2030 CD2 HIS A 259 -27.892 34.221 -27.283 1.00 43.97 C \\\\nATOM 2031 ND1 HIS A 259 -27.951 32.189 -28.145 1.00 43.97 N \\\\nATOM 2032 CE1 HIS A 259 -27.839 33.070 -29.153 1.00 43.97 C \\\\nATOM 2033 NE2 HIS A 259 -27.810 34.324 -28.674 1.00 43.97 N \\\\nATOM 2034 N SER A 260 -30.452 30.116 -23.702 1.00 46.85 N \\\\nATOM 2035 CA SER A 260 -30.347 29.020 -22.745 1.00 46.85 C \\\\nATOM 2036 C SER A 260 -29.341 28.033 -23.325 1.00 46.85 C \\\\nATOM 2037 CB SER A 260 -31.703 28.365 -22.442 1.00 46.85 C \\\\nATOM 2038 O SER A 260 -29.677 27.256 -24.218 1.00 46.85 O \\\\nATOM 2039 OG SER A 260 -32.255 27.717 -23.567 1.00 46.85 O \\\\nATOM 2040 N LEU A 261 -28.090 28.107 -22.870 1.00 57.93 N \\\\nATOM 2041 CA LEU A 261 -27.111 27.052 -23.102 1.00 57.93 C \\\\nATOM 2042 C LEU A 261 -27.748 25.739 -22.633 1.00 57.93 C \\\\nATOM 2043 CB LEU A 261 -25.818 27.369 -22.324 1.00 57.93 C \\\\nATOM 2044 O LEU A 261 -28.035 25.584 -21.445 1.00 57.93 O \\\\nATOM 2045 CG LEU A 261 -25.012 28.555 -22.887 1.00 57.93 C \\\\nATOM 2046 CD1 LEU A 261 -23.962 29.004 -21.869 1.00 57.93 C \\\\nATOM 2047 CD2 LEU A 261 -24.291 28.181 -24.185 1.00 57.93 C \\\\nATOM 2048 N ASP A 262 -28.031 24.838 -23.573 1.00 70.10 N \\\\nATOM 2049 CA ASP A 262 -28.588 23.519 -23.283 1.00 70.10 C \\\\nATOM 2050 C ASP A 262 -27.473 22.683 -22.635 1.00 70.10 C \\\\nATOM 2051 CB ASP A 262 -29.195 22.914 -24.566 1.00 70.10 C \\\\nATOM 2052 O ASP A 262 -26.625 22.085 -23.302 1.00 70.10 O \\\\nATOM 2053 CG ASP A 262 -30.120 21.714 -24.313 1.00 70.10 C \\\\nATOM 2054 OD1 ASP A 262 -30.649 21.595 -23.187 1.00 70.10 O \\\\nATOM 2055 OD2 ASP A 262 -30.301 20.904 -25.257 1.00 70.10 O \\\\nATOM 2056 N LEU A 263 -27.388 22.779 -21.307 1.00 79.04 N \\\\nATOM 2057 CA LEU A 263 -26.398 22.100 -20.479 1.00 79.04 C \\\\nATOM 2058 C LEU A 263 -26.907 20.697 -20.144 1.00 79.04 C \\\\nATOM 2059 CB LEU A 263 -26.142 22.921 -19.199 1.00 79.04 C \\\\nATOM 2060 O LEU A 263 -27.904 20.543 -19.438 1.00 79.04 O \\\\nATOM 2061 CG LEU A 263 -25.343 24.222 -19.402 1.00 79.04 C \\\\nATOM 2062 CD1 LEU A 263 -25.410 25.078 -18.136 1.00 79.04 C \\\\nATOM 2063 CD2 LEU A 263 -23.866 23.953 -19.694 1.00 79.04 C \\\\nATOM 2064 N GLN A 264 -26.191 19.668 -20.593 1.00 82.84 N \\\\nATOM 2065 CA GLN A 264 -26.520 18.281 -20.275 1.00 82.84 C \\\\nATOM 2066 C GLN A 264 -25.827 17.858 -18.964 1.00 82.84 C \\\\nATOM 2067 CB GLN A 264 -26.128 17.375 -21.451 1.00 82.84 C \\\\nATOM 2068 O GLN A 264 -24.595 17.875 -18.900 1.00 82.84 O \\\\nATOM 2069 CG GLN A 264 -26.586 15.919 -21.255 1.00 82.84 C \\\\nATOM 2070 CD GLN A 264 -28.099 15.731 -21.323 1.00 82.84 C \\\\nATOM 2071 NE2 GLN A 264 -28.653 14.767 -20.625 1.00 82.84 N \\\\nATOM 2072 OE1 GLN A 264 -28.816 16.404 -22.041 1.00 82.84 O \\\\nATOM 2073 N PRO A 265 -26.566 17.436 -17.920 1.00 88.13 N \\\\nATOM 2074 CA PRO A 265 -25.963 16.916 -16.697 1.00 88.13 C \\\\nATOM 2075 C PRO A 265 -25.456 15.478 -16.887 1.00 88.13 C \\\\nATOM 2076 CB PRO A 265 -27.061 17.016 -15.634 1.00 88.13 C \\\\nATOM 2077 O PRO A 265 -26.204 14.589 -17.296 1.00 88.13 O \\\\nATOM 2078 CG PRO A 265 -28.351 16.862 -16.442 1.00 88.13 C \\\\nATOM 2079 CD PRO A 265 -28.015 17.515 -17.783 1.00 88.13 C \\\\nATOM 2080 N VAL A 266 -24.196 15.235 -16.522 1.00 88.49 N \\\\nATOM 2081 CA VAL A 266 -23.542 13.920 -16.544 1.00 88.49 C \\\\nATOM 2082 C VAL A 266 -23.222 13.471 -15.117 1.00 88.49 C \\\\nATOM 2083 CB VAL A 266 -22.277 13.943 -17.424 1.00 88.49 C \\\\nATOM 2084 O VAL A 266 -22.374 14.053 -14.434 1.00 88.49 O \\\\nATOM 2085 CG1 VAL A 266 -21.631 12.554 -17.454 1.00 88.49 C \\\\nATOM 2086 CG2 VAL A 266 -22.603 14.340 -18.870 1.00 88.49 C \\\\nATOM 2087 N THR A 267 -23.899 12.416 -14.658 1.00 89.40 N \\\\nATOM 2088 CA THR A 267 -23.777 11.883 -13.292 1.00 89.40 C \\\\nATOM 2089 C THR A 267 -22.712 10.789 -13.167 1.00 89.40 C \\\\nATOM 2090 CB THR A 267 -25.125 11.358 -12.769 1.00 89.40 C \\\\nATOM 2091 O THR A 267 -22.523 9.952 -14.059 1.00 89.40 O \\\\nATOM 2092 CG2 THR A 267 -26.161 12.469 -12.601 1.00 89.40 C \\\\nATOM 2093 OG1 THR A 267 -25.678 10.415 -13.657 1.00 89.40 O \\\\nATOM 2094 N TYR A 268 -22.040 10.769 -12.013 1.00 89.45 N \\\\nATOM 2095 CA TYR A 268 -21.136 9.689 -11.622 1.00 89.45 C \\\\nATOM 2096 C TYR A 268 -21.918 8.409 -11.295 1.00 89.45 C \\\\nATOM 2097 CB TYR A 268 -20.292 10.126 -10.418 1.00 89.45 C \\\\nATOM 2098 O TYR A 268 -22.978 8.457 -10.670 1.00 89.45 O \\\\nATOM 2099 CG TYR A 268 -19.250 9.105 -9.993 1.00 89.45 C \\\\nATOM 2100 CD1 TYR A 268 -19.514 8.182 -8.961 1.00 89.45 C \\\\nATOM 2101 CD2 TYR A 268 -18.001 9.084 -10.631 1.00 89.45 C \\\\nATOM 2102 CE1 TYR A 268 -18.526 7.253 -8.569 1.00 89.45 C \\\\nATOM 2103 CE2 TYR A 268 -17.000 8.186 -10.220 1.00 89.45 C \\\\nATOM 2104 OH TYR A 268 -16.280 6.389 -8.811 1.00 89.45 O \\\\nATOM 2105 CZ TYR A 268 -17.259 7.256 -9.192 1.00 89.45 C \\\\nATOM 2106 N SER A 269 -21.368 7.259 -11.680 1.00 85.81 N \\\\nATOM 2107 CA SER A 269 -21.863 5.937 -11.292 1.00 85.81 C \\\\nATOM 2108 C SER A 269 -20.695 5.073 -10.841 1.00 85.81 C \\\\nATOM 2109 CB SER A 269 -22.624 5.259 -12.439 1.00 85.81 C \\\\nATOM 2110 O SER A 269 -19.671 5.038 -11.516 1.00 85.81 O \\\\nATOM 2111 OG SER A 269 -21.890 5.242 -13.658 1.00 85.81 O \\\\nATOM 2112 N GLU A 270 -20.845 4.374 -9.718 1.00 86.25 N \\\\nATOM 2113 CA GLU A 270 -19.789 3.501 -9.206 1.00 86.25 C \\\\nATOM 2114 C GLU A 270 -19.738 2.192 -10.023 1.00 86.25 C \\\\nATOM 2115 CB GLU A 270 -20.010 3.232 -7.709 1.00 86.25 C \\\\nATOM 2116 O GLU A 270 -20.766 1.516 -10.152 1.00 86.25 O \\\\nATOM 2117 CG GLU A 270 -18.728 2.796 -6.984 1.00 86.25 C \\\\nATOM 2118 CD GLU A 270 -17.764 3.974 -6.775 1.00 86.25 C \\\\nATOM 2119 OE1 GLU A 270 -16.707 4.031 -7.432 1.00 86.25 O \\\\nATOM 2120 OE2 GLU A 270 -18.057 4.870 -5.955 1.00 86.25 O \\\\nATOM 2121 N PRO A 271 -18.581 1.815 -10.592 1.00 91.14 N \\\\nATOM 2122 CA PRO A 271 -18.441 0.578 -11.353 1.00 91.14 C \\\\nATOM 2123 C PRO A 271 -18.353 -0.655 -10.440 1.00 91.14 C \\\\nATOM 2124 CB PRO A 271 -17.169 0.768 -12.180 1.00 91.14 C \\\\nATOM 2125 O PRO A 271 -17.957 -0.569 -9.280 1.00 91.14 O \\\\nATOM 2126 CG PRO A 271 -16.321 1.650 -11.272 1.00 91.14 C \\\\nATOM 2127 CD PRO A 271 -17.340 2.574 -10.621 1.00 91.14 C \\\\nATOM 2128 N ALA A 272 -18.644 -1.837 -10.995 1.00 89.84 N \\\\nATOM 2129 CA ALA A 272 -18.530 -3.114 -10.275 1.00 89.84 C \\\\nATOM 2130 C ALA A 272 -17.092 -3.431 -9.816 1.00 89.84 C \\\\nATOM 2131 CB ALA A 272 -19.057 -4.227 -11.189 1.00 89.84 C \\\\nATOM 2132 O ALA A 272 -16.889 -4.063 -8.781 1.00 89.84 O \\\\nATOM 2133 N PHE A 273 -16.099 -2.982 -10.588 1.00 94.27 N \\\\nATOM 2134 CA PHE A 273 -14.688 -3.017 -10.220 1.00 94.27 C \\\\nATOM 2135 C PHE A 273 -14.194 -1.585 -10.114 1.00 94.27 C \\\\nATOM 2136 CB PHE A 273 -13.874 -3.797 -11.260 1.00 94.27 C \\\\nATOM 2137 O PHE A 273 -14.209 -0.868 -11.114 1.00 94.27 O \\\\nATOM 2138 CG PHE A 273 -14.326 -5.227 -11.449 1.00 94.27 C \\\\nATOM 2139 CD1 PHE A 273 -13.887 -6.225 -10.564 1.00 94.27 C \\\\nATOM 2140 CD2 PHE A 273 -15.184 -5.565 -12.512 1.00 94.27 C \\\\nATOM 2141 CE1 PHE A 273 -14.299 -7.557 -10.732 1.00 94.27 C \\\\nATOM 2142 CE2 PHE A 273 -15.603 -6.897 -12.679 1.00 94.27 C \\\\nATOM 2143 CZ PHE A 273 -15.162 -7.892 -11.790 1.00 94.27 C \\\\nATOM 2144 N TRP A 274 -13.742 -1.160 -8.939 1.00 95.07 N \\\\nATOM 2145 CA TRP A 274 -13.333 0.229 -8.720 1.00 95.07 C \\\\nATOM 2146 C TRP A 274 -11.968 0.541 -9.349 1.00 95.07 C \\\\nATOM 2147 CB TRP A 274 -13.369 0.531 -7.223 1.00 95.07 C \\\\nATOM 2148 O TRP A 274 -11.717 1.679 -9.749 1.00 95.07 O \\\\nATOM 2149 CG TRP A 274 -12.348 -0.198 -6.411 1.00 95.07 C \\\\nATOM 2150 CD1 TRP A 274 -12.518 -1.390 -5.799 1.00 95.07 C \\\\nATOM 2151 CD2 TRP A 274 -10.987 0.221 -6.105 1.00 95.07 C \\\\nATOM 2152 CE2 TRP A 274 -10.390 -0.761 -5.262 1.00 95.07 C \\\\nATOM 2153 CE3 TRP A 274 -10.209 1.350 -6.438 1.00 95.07 C \\\\nATOM 2154 NE1 TRP A 274 -11.364 -1.725 -5.122 1.00 95.07 N \\\\nATOM 2155 CH2 TRP A 274 -8.338 0.512 -5.116 1.00 95.07 C \\\\nATOM 2156 CZ2 TRP A 274 -9.095 -0.612 -4.746 1.00 95.07 C \\\\nATOM 2157 CZ3 TRP A 274 -8.892 1.487 -5.963 1.00 95.07 C \\\\nATOM 2158 N CYS A 275 -11.102 -0.468 -9.505 1.00 97.41 N \\\\nATOM 2159 CA CYS A 275 -9.862 -0.335 -10.263 1.00 97.41 C \\\\nATOM 2160 C CYS A 275 -9.446 -1.606 -11.010 1.00 97.41 C \\\\nATOM 2161 CB CYS A 275 -8.727 0.177 -9.357 1.00 97.41 C \\\\nATOM 2162 O CYS A 275 -9.892 -2.718 -10.710 1.00 97.41 O \\\\nATOM 2163 SG CYS A 275 -8.172 -1.078 -8.170 1.00 97.41 S \\\\nATOM 2164 N SER A 276 -8.544 -1.421 -11.972 1.00 97.86 N \\\\nATOM 2165 CA SER A 276 -7.793 -2.494 -12.626 1.00 97.86 C \\\\nATOM 2166 C SER A 276 -6.289 -2.268 -12.470 1.00 97.86 C \\\\nATOM 2167 CB SER A 276 -8.208 -2.627 -14.092 1.00 97.86 C \\\\nATOM 2168 O SER A 276 -5.836 -1.124 -12.540 1.00 97.86 O \\\\nATOM 2169 OG SER A 276 -7.734 -1.550 -14.869 1.00 97.86 O \\\\nATOM 2170 N ILE A 277 -5.524 -3.339 -12.253 1.00 98.47 N \\\\nATOM 2171 CA ILE A 277 -4.088 -3.291 -11.952 1.00 98.47 C \\\\nATOM 2172 C ILE A 277 -3.315 -4.126 -12.969 1.00 98.47 C \\\\nATOM 2173 CB ILE A 277 -3.763 -3.772 -10.515 1.00 98.47 C \\\\nATOM 2174 O ILE A 277 -3.540 -5.331 -13.081 1.00 98.47 O \\\\nATOM 2175 CG1 ILE A 277 -4.882 -3.422 -9.506 1.00 98.47 C \\\\nATOM 2176 CG2 ILE A 277 -2.366 -3.251 -10.127 1.00 98.47 C \\\\nATOM 2177 CD1 ILE A 277 -4.496 -3.473 -8.027 1.00 98.47 C \\\\nATOM 2178 N ALA A 278 -2.370 -3.509 -13.673 1.00 98.55 N \\\\nATOM 2179 CA ALA A 278 -1.424 -4.200 -14.544 1.00 98.55 C \\\\nATOM 2180 C ALA A 278 -0.030 -4.218 -13.905 1.00 98.55 C \\\\nATOM 2181 CB ALA A 278 -1.436 -3.533 -15.922 1.00 98.55 C \\\\nATOM 2182 O ALA A 278 0.429 -3.200 -13.390 1.00 98.55 O \\\\nATOM 2183 N TYR A 279 0.645 -5.369 -13.934 1.00 98.63 N \\\\nATOM 2184 CA TYR A 279 2.011 -5.519 -13.431 1.00 98.63 C \\\\nATOM 2185 C TYR A 279 3.033 -5.476 -14.565 1.00 98.63 C \\\\nATOM 2186 CB TYR A 279 2.130 -6.801 -12.598 1.00 98.63 C \\\\nATOM 2187 O TYR A 279 2.824 -6.041 -15.641 1.00 98.63 O \\\\nATOM 2188 CG TYR A 279 3.542 -7.114 -12.125 1.00 98.63 C \\\\nATOM 2189 CD1 TYR A 279 4.171 -8.309 -12.518 1.00 98.63 C \\\\nATOM 2190 CD2 TYR A 279 4.229 -6.208 -11.296 1.00 98.63 C \\\\nATOM 2191 CE1 TYR A 279 5.469 -8.611 -12.068 1.00 98.63 C \\\\nATOM 2192 CE2 TYR A 279 5.536 -6.493 -10.858 1.00 98.63 C \\\\nATOM 2193 OH TYR A 279 7.386 -8.020 -10.749 1.00 98.63 O \\\\nATOM 2194 CZ TYR A 279 6.152 -7.707 -11.229 1.00 98.63 C \\\\nATOM 2195 N TYR A 280 4.157 -4.820 -14.295 1.00 98.73 N \\\\nATOM 2196 CA TYR A 280 5.253 -4.645 -15.227 1.00 98.73 C \\\\nATOM 2197 C TYR A 280 6.598 -4.950 -14.563 1.00 98.73 C \\\\nATOM 2198 CB TYR A 280 5.235 -3.217 -15.775 1.00 98.73 C \\\\nATOM 2199 O TYR A 280 6.865 -4.613 -13.403 1.00 98.73 O \\\\nATOM 2200 CG TYR A 280 4.056 -2.864 -16.663 1.00 98.73 C \\\\nATOM 2201 CD1 TYR A 280 4.181 -2.933 -18.064 1.00 98.73 C \\\\nATOM 2202 CD2 TYR A 280 2.855 -2.401 -16.090 1.00 98.73 C \\\\nATOM 2203 CE1 TYR A 280 3.098 -2.569 -18.890 1.00 98.73 C \\\\nATOM 2204 CE2 TYR A 280 1.780 -2.014 -16.913 1.00 98.73 C \\\\nATOM 2205 OH TYR A 280 0.868 -1.716 -19.113 1.00 98.73 O \\\\nATOM 2206 CZ TYR A 280 1.896 -2.105 -18.315 1.00 98.73 C \\\\nATOM 2207 N GLU A 281 7.479 -5.555 -15.351 1.00 98.51 N \\\\nATOM 2208 CA GLU A 281 8.898 -5.694 -15.056 1.00 98.51 C \\\\nATOM 2209 C GLU A 281 9.661 -4.903 -16.118 1.00 98.51 C \\\\nATOM 2210 CB GLU A 281 9.305 -7.179 -15.015 1.00 98.51 C \\\\nATOM 2211 O GLU A 281 9.632 -5.253 -17.297 1.00 98.51 O \\\\nATOM 2212 CG GLU A 281 8.652 -7.916 -13.832 1.00 98.51 C \\\\nATOM 2213 CD GLU A 281 8.992 -9.413 -13.731 1.00 98.51 C \\\\nATOM 2214 OE1 GLU A 281 8.462 -10.094 -12.822 1.00 98.51 O \\\\nATOM 2215 OE2 GLU A 281 9.816 -9.955 -14.502 1.00 98.51 O \\\\nATOM 2216 N LEU A 282 10.322 -3.812 -15.716 1.00 97.97 N \\\\nATOM 2217 CA LEU A 282 10.910 -2.843 -16.646 1.00 97.97 C \\\\nATOM 2218 C LEU A 282 9.847 -2.264 -17.600 1.00 97.97 C \\\\nATOM 2219 CB LEU A 282 12.144 -3.445 -17.358 1.00 97.97 C \\\\nATOM 2220 O LEU A 282 8.870 -1.684 -17.146 1.00 97.97 O \\\\nATOM 2221 CG LEU A 282 13.223 -3.999 -16.419 1.00 97.97 C \\\\nATOM 2222 CD1 LEU A 282 14.239 -4.800 -17.230 1.00 97.97 C \\\\nATOM 2223 CD2 LEU A 282 13.966 -2.879 -15.685 1.00 97.97 C \\\\nATOM 2224 N ASN A 283 10.004 -2.398 -18.913 1.00 97.02 N \\\\nATOM 2225 CA ASN A 283 9.026 -1.967 -19.914 1.00 97.02 C \\\\nATOM 2226 C ASN A 283 8.091 -3.098 -20.380 1.00 97.02 C \\\\nATOM 2227 CB ASN A 283 9.777 -1.319 -21.090 1.00 97.02 C \\\\nATOM 2228 O ASN A 283 7.291 -2.881 -21.287 1.00 97.02 O \\\\nATOM 2229 CG ASN A 283 10.673 -2.289 -21.843 1.00 97.02 C \\\\nATOM 2230 ND2 ASN A 283 10.969 -2.008 -23.087 1.00 97.02 N \\\\nATOM 2231 OD1 ASN A 283 11.151 -3.283 -21.320 1.00 97.02 O \\\\nATOM 2232 N GLN A 284 8.187 -4.297 -19.798 1.00 97.84 N \\\\nATOM 2233 CA GLN A 284 7.410 -5.460 -20.216 1.00 97.84 C \\\\nATOM 2234 C GLN A 284 6.244 -5.708 -19.260 1.00 97.84 C \\\\nATOM 2235 CB GLN A 284 8.342 -6.674 -20.321 1.00 97.84 C \\\\nATOM 2236 O GLN A 284 6.435 -5.811 -18.048 1.00 97.84 O \\\\nATOM 2237 CG GLN A 284 7.625 -7.885 -20.934 1.00 97.84 C \\\\nATOM 2238 CD GLN A 284 8.527 -9.101 -21.097 1.00 97.84 C \\\\nATOM 2239 NE2 GLN A 284 8.044 -10.153 -21.718 1.00 97.84 N \\\\nATOM 2240 OE1 GLN A 284 9.677 -9.143 -20.691 1.00 97.84 O \\\\nATOM 2241 N ARG A 285 5.033 -5.853 -19.806 1.00 98.04 N \\\\nATOM 2242 CA ARG A 285 3.860 -6.294 -19.041 1.00 98.04 C \\\\nATOM 2243 C ARG A 285 3.996 -7.771 -18.681 1.00 98.04 C \\\\nATOM 2244 CB ARG A 285 2.586 -6.010 -19.841 1.00 98.04 C \\\\nATOM 2245 O ARG A 285 4.353 -8.586 -19.531 1.00 98.04 O \\\\nATOM 2246 CG ARG A 285 1.316 -6.279 -19.020 1.00 98.04 C \\\\nATOM 2247 CD ARG A 285 0.115 -5.771 -19.815 1.00 98.04 C \\\\nATOM 2248 NE ARG A 285 -1.167 -6.187 -19.224 1.00 98.04 N \\\\nATOM 2249 NH1 ARG A 285 -2.464 -5.493 -20.990 1.00 98.04 N \\\\nATOM 2250 NH2 ARG A 285 -3.411 -6.566 -19.315 1.00 98.04 N \\\\nATOM 2251 CZ ARG A 285 -2.332 -6.079 -19.834 1.00 98.04 C \\\\nATOM 2252 N VAL A 286 3.700 -8.113 -17.432 1.00 98.24 N \\\\nATOM 2253 CA VAL A 286 3.852 -9.466 -16.892 1.00 98.24 C \\\\nATOM 2254 C VAL A 286 2.558 -9.890 -16.201 1.00 98.24 C \\\\nATOM 2255 CB VAL A 286 5.064 -9.534 -15.940 1.00 98.24 C \\\\nATOM 2256 O VAL A 286 2.137 -9.270 -15.229 1.00 98.24 O \\\\nATOM 2257 CG1 VAL A 286 5.211 -10.922 -15.307 1.00 98.24 C \\\\nATOM 2258 CG2 VAL A 286 6.374 -9.224 -16.675 1.00 98.24 C \\\\nATOM 2259 N GLY A 287 1.964 -10.987 -16.673 1.00 96.53 N \\\\nATOM 2260 CA GLY A 287 0.712 -11.524 -16.137 1.00 96.53 C \\\\nATOM 2261 C GLY A 287 -0.550 -10.832 -16.658 1.00 96.53 C \\\\nATOM 2262 O GLY A 287 -0.506 -9.941 -17.509 1.00 96.53 O \\\\nATOM 2263 N GLU A 288 -1.691 -11.282 -16.143 1.00 95.82 N \\\\nATOM 2264 CA GLU A 288 -3.015 -10.746 -16.466 1.00 95.82 C \\\\nATOM 2265 C GLU A 288 -3.318 -9.466 -15.673 1.00 95.82 C \\\\nATOM 2266 CB GLU A 288 -4.087 -11.816 -16.208 1.00 95.82 C \\\\nATOM 2267 O GLU A 288 -2.705 -9.190 -14.639 1.00 95.82 O \\\\nATOM 2268 CG GLU A 288 -3.880 -13.061 -17.087 1.00 95.82 C \\\\nATOM 2269 CD GLU A 288 -4.966 -14.124 -16.878 1.00 95.82 C \\\\nATOM 2270 OE1 GLU A 288 -5.203 -14.883 -17.841 1.00 95.82 O \\\\nATOM 2271 OE2 GLU A 288 -5.517 -14.185 -15.757 1.00 95.82 O \\\\nATOM 2272 N THR A 289 -4.281 -8.673 -16.151 1.00 97.10 N \\\\nATOM 2273 CA THR A 289 -4.793 -7.538 -15.371 1.00 97.10 C \\\\nATOM 2274 C THR A 289 -5.664 -8.040 -14.233 1.00 97.10 C \\\\nATOM 2275 CB THR A 289 -5.594 -6.550 -16.222 1.00 97.10 C \\\\nATOM 2276 O THR A 289 -6.643 -8.753 -14.450 1.00 97.10 O \\\\nATOM 2277 CG2 THR A 289 -6.231 -5.405 -15.443 1.00 97.10 C \\\\nATOM 2278 OG1 THR A 289 -4.718 -5.889 -17.089 1.00 97.10 O \\\\nATOM 2279 N PHE A 290 -5.354 -7.596 -13.022 1.00 96.97 N \\\\nATOM 2280 CA PHE A 290 -6.176 -7.846 -11.851 1.00 96.97 C \\\\nATOM 2281 C PHE A 290 -7.320 -6.830 -11.776 1.00 96.97 C \\\\nATOM 2282 CB PHE A 290 -5.278 -7.792 -10.620 1.00 96.97 C \\\\nATOM 2283 O PHE A 290 -7.086 -5.631 -11.914 1.00 96.97 O \\\\nATOM 2284 CG PHE A 290 -5.994 -8.160 -9.344 1.00 96.97 C \\\\nATOM 2285 CD1 PHE A 290 -6.638 -7.167 -8.583 1.00 96.97 C \\\\nATOM 2286 CD2 PHE A 290 -6.019 -9.502 -8.923 1.00 96.97 C \\\\nATOM 2287 CE1 PHE A 290 -7.286 -7.513 -7.387 1.00 96.97 C \\\\nATOM 2288 CE2 PHE A 290 -6.657 -9.847 -7.721 1.00 96.97 C \\\\nATOM 2289 CZ PHE A 290 -7.279 -8.850 -6.953 1.00 96.97 C \\\\nATOM 2290 N HIS A 291 -8.545 -7.287 -11.519 1.00 96.94 N \\\\nATOM 2291 CA HIS A 291 -9.725 -6.426 -11.405 1.00 96.94 C \\\\nATOM 2292 C HIS A 291 -10.249 -6.449 -9.969 1.00 96.94 C \\\\nATOM 2293 CB HIS A 291 -10.791 -6.861 -12.416 1.00 96.94 C \\\\nATOM 2294 O HIS A 291 -10.591 -7.504 -9.439 1.00 96.94 O \\\\nATOM 2295 CG HIS A 291 -10.338 -6.727 -13.848 1.00 96.94 C \\\\nATOM 2296 CD2 HIS A 291 -10.580 -5.670 -14.683 1.00 96.94 C \\\\nATOM 2297 ND1 HIS A 291 -9.591 -7.641 -14.559 1.00 96.94 N \\\\nATOM 2298 CE1 HIS A 291 -9.403 -7.152 -15.793 1.00 96.94 C \\\\nATOM 2299 NE2 HIS A 291 -9.971 -5.943 -15.910 1.00 96.94 N \\\\nATOM 2300 N ALA A 292 -10.304 -5.281 -9.332 1.00 94.85 N \\\\nATOM 2301 CA ALA A 292 -10.612 -5.160 -7.915 1.00 94.85 C \\\\nATOM 2302 C ALA A 292 -12.092 -4.856 -7.678 1.00 94.85 C \\\\nATOM 2303 CB ALA A 292 -9.737 -4.054 -7.345 1.00 94.85 C \\\\nATOM 2304 O ALA A 292 -12.557 -3.755 -7.970 1.00 94.85 O \\\\nATOM 2305 N SER A 293 -12.831 -5.824 -7.138 1.00 91.03 N \\\\nATOM 2306 CA SER A 293 -14.233 -5.637 -6.736 1.00 91.03 C \\\\nATOM 2307 C SER A 293 -14.364 -5.249 -5.264 1.00 91.03 C \\\\nATOM 2308 CB SER A 293 -15.029 -6.910 -7.021 1.00 91.03 C \\\\nATOM 2309 O SER A 293 -15.207 -4.432 -4.909 1.00 91.03 O \\\\nATOM 2310 OG SER A 293 -14.425 -8.035 -6.398 1.00 91.03 O \\\\nATOM 2311 N GLN A 294 -13.508 -5.801 -4.401 1.00 90.62 N \\\\nATOM 2312 CA GLN A 294 -13.521 -5.508 -2.970 1.00 90.62 C \\\\nATOM 2313 C GLN A 294 -12.933 -4.120 -2.681 1.00 90.62 C \\\\nATOM 2314 CB GLN A 294 -12.771 -6.602 -2.189 1.00 90.62 C \\\\nATOM 2315 O GLN A 294 -11.941 -3.742 -3.312 1.00 90.62 O \\\\nATOM 2316 CG GLN A 294 -13.435 -7.982 -2.320 1.00 90.62 C \\\\nATOM 2317 CD GLN A 294 -14.891 -7.991 -1.863 1.00 90.62 C \\\\nATOM 2318 NE2 GLN A 294 -15.742 -8.766 -2.496 1.00 90.62 N \\\\nATOM 2319 OE1 GLN A 294 -15.304 -7.279 -0.963 1.00 90.62 O \\\\nATOM 2320 N PRO A 295 -13.460 -3.378 -1.687 1.00 89.93 N \\\\nATOM 2321 CA PRO A 295 -12.981 -2.036 -1.345 1.00 89.93 C \\\\nATOM 2322 C PRO A 295 -11.551 -2.033 -0.797 1.00 89.93 C \\\\nATOM 2323 CB PRO A 295 -13.969 -1.515 -0.295 1.00 89.93 C \\\\nATOM 2324 O PRO A 295 -10.946 -0.978 -0.670 1.00 89.93 O \\\\nATOM 2325 CG PRO A 295 -14.477 -2.789 0.379 1.00 89.93 C \\\\nATOM 2326 CD PRO A 295 -14.529 -3.779 -0.780 1.00 89.93 C \\\\nATOM 2327 N SER A 296 -10.995 -3.195 -0.456 1.00 92.89 N \\\\nATOM 2328 CA SER A 296 -9.617 -3.358 -0.006 1.00 92.89 C \\\\nATOM 2329 C SER A 296 -8.981 -4.532 -0.741 1.00 92.89 C \\\\nATOM 2330 CB SER A 296 -9.600 -3.576 1.509 1.00 92.89 C \\\\nATOM 2331 O SER A 296 -9.544 -5.622 -0.763 1.00 92.89 O \\\\nATOM 2332 OG SER A 296 -8.313 -3.961 1.962 1.00 92.89 O \\\\nATOM 2333 N LEU A 297 -7.772 -4.335 -1.261 1.00 96.06 N \\\\nATOM 2334 CA LEU A 297 -6.951 -5.391 -1.853 1.00 96.06 C \\\\nATOM 2335 C LEU A 297 -5.479 -5.222 -1.463 1.00 96.06 C \\\\nATOM 2336 CB LEU A 297 -7.161 -5.421 -3.378 1.00 96.06 C \\\\nATOM 2337 O LEU A 297 -5.037 -4.141 -1.076 1.00 96.06 O \\\\nATOM 2338 CG LEU A 297 -6.436 -4.267 -4.101 1.00 96.06 C \\\\nATOM 2339 CD1 LEU A 297 -5.200 -4.773 -4.846 1.00 96.06 C \\\\nATOM 2340 CD2 LEU A 297 -7.335 -3.596 -5.117 1.00 96.06 C \\\\nATOM 2341 N THR A 298 -4.699 -6.290 -1.571 1.00 97.78 N \\\\nATOM 2342 CA THR A 298 -3.249 -6.266 -1.349 1.00 97.78 C \\\\nATOM 2343 C THR A 298 -2.525 -6.752 -2.597 1.00 97.78 C \\\\nATOM 2344 CB THR A 298 -2.871 -7.103 -0.118 1.00 97.78 C \\\\nATOM 2345 O THR A 298 -2.809 -7.838 -3.088 1.00 97.78 O \\\\nATOM 2346 CG2 THR A 298 -1.411 -6.913 0.276 1.00 97.78 C \\\\nATOM 2347 OG1 THR A 298 -3.663 -6.707 0.989 1.00 97.78 O \\\\nATOM 2348 N VAL A 299 -1.578 -5.969 -3.109 1.00 98.41 N \\\\nATOM 2349 CA VAL A 299 -0.645 -6.407 -4.154 1.00 98.41 C \\\\nATOM 2350 C VAL A 299 0.644 -6.826 -3.462 1.00 98.41 C \\\\nATOM 2351 CB VAL A 299 -0.384 -5.311 -5.202 1.00 98.41 C \\\\nATOM 2352 O VAL A 299 1.325 -5.978 -2.886 1.00 98.41 O \\\\nATOM 2353 CG1 VAL A 299 0.448 -5.885 -6.351 1.00 98.41 C \\\\nATOM 2354 CG2 VAL A 299 -1.672 -4.700 -5.766 1.00 98.41 C \\\\nATOM 2355 N ASP A 300 0.964 -8.118 -3.477 1.00 98.33 N \\\\nATOM 2356 CA ASP A 300 2.064 -8.694 -2.697 1.00 98.33 C \\\\nATOM 2357 C ASP A 300 2.994 -9.587 -3.532 1.00 98.33 C \\\\nATOM 2358 CB ASP A 300 1.516 -9.372 -1.427 1.00 98.33 C \\\\nATOM 2359 O ASP A 300 2.729 -9.896 -4.690 1.00 98.33 O \\\\nATOM 2360 CG ASP A 300 0.725 -10.659 -1.648 1.00 98.33 C \\\\nATOM 2361 OD1 ASP A 300 1.220 -11.561 -2.354 1.00 98.33 O \\\\nATOM 2362 OD2 ASP A 300 -0.292 -10.861 -0.942 1.00 98.33 O \\\\nATOM 2363 N GLY A 301 4.136 -9.963 -2.957 1.00 97.82 N \\\\nATOM 2364 CA GLY A 301 5.156 -10.794 -3.602 1.00 97.82 C \\\\nATOM 2365 C GLY A 301 4.979 -12.297 -3.375 1.00 97.82 C \\\\nATOM 2366 O GLY A 301 5.909 -13.049 -3.660 1.00 97.82 O \\\\nATOM 2367 N PHE A 302 3.843 -12.743 -2.830 1.00 97.35 N \\\\nATOM 2368 CA PHE A 302 3.573 -14.155 -2.546 1.00 97.35 C \\\\nATOM 2369 C PHE A 302 2.885 -14.841 -3.740 1.00 97.35 C \\\\nATOM 2370 CB PHE A 302 2.783 -14.263 -1.232 1.00 97.35 C \\\\nATOM 2371 O PHE A 302 2.907 -14.325 -4.856 1.00 97.35 O \\\\nATOM 2372 CG PHE A 302 3.435 -13.594 -0.030 1.00 97.35 C \\\\nATOM 2373 CD1 PHE A 302 4.690 -14.039 0.428 1.00 97.35 C \\\\nATOM 2374 CD2 PHE A 302 2.791 -12.539 0.644 1.00 97.35 C \\\\nATOM 2375 CE1 PHE A 302 5.291 -13.437 1.547 1.00 97.35 C \\\\nATOM 2376 CE2 PHE A 302 3.385 -11.946 1.771 1.00 97.35 C \\\\nATOM 2377 CZ PHE A 302 4.638 -12.392 2.223 1.00 97.35 C \\\\nATOM 2378 N THR A 303 2.335 -16.044 -3.546 1.00 96.72 N \\\\nATOM 2379 CA THR A 303 1.984 -16.964 -4.647 1.00 96.72 C \\\\nATOM 2380 C THR A 303 0.567 -17.547 -4.562 1.00 96.72 C \\\\nATOM 2381 CB THR A 303 3.019 -18.101 -4.740 1.00 96.72 C \\\\nATOM 2382 O THR A 303 0.355 -18.666 -5.015 1.00 96.72 O \\\\nATOM 2383 CG2 THR A 303 4.447 -17.610 -4.978 1.00 96.72 C \\\\nATOM 2384 OG1 THR A 303 3.013 -18.832 -3.534 1.00 96.72 O \\\\nATOM 2385 N ASP A 304 -0.398 -16.851 -3.956 1.00 94.15 N \\\\nATOM 2386 CA ASP A 304 -1.798 -17.309 -3.915 1.00 94.15 C \\\\nATOM 2387 C ASP A 304 -2.532 -16.889 -5.205 1.00 94.15 C \\\\nATOM 2388 CB ASP A 304 -2.473 -16.747 -2.658 1.00 94.15 C \\\\nATOM 2389 O ASP A 304 -2.710 -15.693 -5.423 1.00 94.15 O \\\\nATOM 2390 CG ASP A 304 -3.936 -17.159 -2.451 1.00 94.15 C \\\\nATOM 2391 OD1 ASP A 304 -4.527 -17.856 -3.318 1.00 94.15 O \\\\nATOM 2392 OD2 ASP A 304 -4.436 -16.746 -1.375 1.00 94.15 O \\\\nATOM 2393 N PRO A 305 -2.946 -17.827 -6.077 1.00 91.29 N \\\\nATOM 2394 CA PRO A 305 -3.564 -17.491 -7.360 1.00 91.29 C \\\\nATOM 2395 C PRO A 305 -5.070 -17.204 -7.267 1.00 91.29 C \\\\nATOM 2396 CB PRO A 305 -3.296 -18.721 -8.232 1.00 91.29 C \\\\nATOM 2397 O PRO A 305 -5.663 -16.781 -8.252 1.00 91.29 O \\\\nATOM 2398 CG PRO A 305 -3.376 -19.872 -7.230 1.00 91.29 C \\\\nATOM 2399 CD PRO A 305 -2.768 -19.270 -5.965 1.00 91.29 C \\\\nATOM 2400 N SER A 306 -5.711 -17.495 -6.131 1.00 88.57 N \\\\nATOM 2401 CA SER A 306 -7.172 -17.684 -6.059 1.00 88.57 C \\\\nATOM 2402 C SER A 306 -7.919 -16.630 -5.244 1.00 88.57 C \\\\nATOM 2403 CB SER A 306 -7.461 -19.087 -5.524 1.00 88.57 C \\\\nATOM 2404 O SER A 306 -9.147 -16.650 -5.163 1.00 88.57 O \\\\nATOM 2405 OG SER A 306 -6.983 -19.271 -4.198 1.00 88.57 O \\\\nATOM 2406 N ASN A 307 -7.193 -15.712 -4.614 1.00 87.96 N \\\\nATOM 2407 CA ASN A 307 -7.768 -14.765 -3.675 1.00 87.96 C \\\\nATOM 2408 C ASN A 307 -8.130 -13.440 -4.363 1.00 87.96 C \\\\nATOM 2409 CB ASN A 307 -6.780 -14.647 -2.514 1.00 87.96 C \\\\nATOM 2410 O ASN A 307 -7.258 -12.690 -4.791 1.00 87.96 O \\\\nATOM 2411 CG ASN A 307 -7.307 -13.822 -1.365 1.00 87.96 C \\\\nATOM 2412 ND2 ASN A 307 -6.954 -14.183 -0.156 1.00 87.96 N \\\\nATOM 2413 OD1 ASN A 307 -8.048 -12.869 -1.514 1.00 87.96 O \\\\nATOM 2414 N SER A 308 -9.423 -13.110 -4.406 1.00 89.03 N \\\\nATOM 2415 CA SER A 308 -9.940 -11.878 -5.023 1.00 89.03 C \\\\nATOM 2416 C SER A 308 -9.550 -10.582 -4.298 1.00 89.03 C \\\\nATOM 2417 CB SER A 308 -11.465 -11.960 -5.118 1.00 89.03 C \\\\nATOM 2418 O SER A 308 -9.783 -9.498 -4.821 1.00 89.03 O \\\\nATOM 2419 OG SER A 308 -12.037 -12.143 -3.834 1.00 89.03 O \\\\nATOM 2420 N GLU A 309 -8.983 -10.665 -3.094 1.00 92.14 N \\\\nATOM 2421 CA GLU A 309 -8.434 -9.529 -2.341 1.00 92.14 C \\\\nATOM 2422 C GLU A 309 -6.903 -9.457 -2.441 1.00 92.14 C \\\\nATOM 2423 CB GLU A 309 -8.846 -9.615 -0.863 1.00 92.14 C \\\\nATOM 2424 O GLU A 309 -6.290 -8.568 -1.843 1.00 92.14 O \\\\nATOM 2425 CG GLU A 309 -10.360 -9.535 -0.631 1.00 92.14 C \\\\nATOM 2426 CD GLU A 309 -10.740 -9.691 0.853 1.00 92.14 C \\\\nATOM 2427 OE1 GLU A 309 -11.953 -9.833 1.122 1.00 92.14 O \\\\nATOM 2428 OE2 GLU A 309 -9.837 -9.684 1.728 1.00 92.14 O \\\\nATOM 2429 N ARG A 310 -6.252 -10.390 -3.154 1.00 96.04 N \\\\nATOM 2430 CA ARG A 310 -4.791 -10.445 -3.258 1.00 96.04 C \\\\nATOM 2431 C ARG A 310 -4.327 -10.595 -4.697 1.00 96.04 C \\\\nATOM 2432 CB ARG A 310 -4.203 -11.564 -2.396 1.00 96.04 C \\\\nATOM 2433 O ARG A 310 -4.538 -11.619 -5.333 1.00 96.04 O \\\\nATOM 2434 CG ARG A 310 -4.527 -11.394 -0.906 1.00 96.04 C \\\\nATOM 2435 CD ARG A 310 -3.942 -12.550 -0.098 1.00 96.04 C \\\\nATOM 2436 NE ARG A 310 -2.472 -12.565 -0.148 1.00 96.04 N \\\\nATOM 2437 NH1 ARG A 310 -2.160 -14.826 0.181 1.00 96.04 N \\\\nATOM 2438 NH2 ARG A 310 -0.422 -13.452 -0.107 1.00 96.04 N \\\\nATOM 2439 CZ ARG A 310 -1.701 -13.620 -0.017 1.00 96.04 C \\\\nATOM 2440 N PHE A 311 -3.589 -9.599 -5.170 1.00 97.27 N \\\\nATOM 2441 CA PHE A 311 -2.848 -9.704 -6.414 1.00 97.27 C \\\\nATOM 2442 C PHE A 311 -1.417 -10.164 -6.116 1.00 97.27 C \\\\nATOM 2443 CB PHE A 311 -2.922 -8.385 -7.183 1.00 97.27 C \\\\nATOM 2444 O PHE A 311 -0.531 -9.370 -5.791 1.00 97.27 O \\\\nATOM 2445 CG PHE A 311 -2.310 -8.407 -8.574 1.00 97.27 C \\\\nATOM 2446 CD1 PHE A 311 -1.940 -7.188 -9.172 1.00 97.27 C \\\\nATOM 2447 CD2 PHE A 311 -2.148 -9.609 -9.300 1.00 97.27 C \\\\nATOM 2448 CE1 PHE A 311 -1.416 -7.167 -10.476 1.00 97.27 C \\\\nATOM 2449 CE2 PHE A 311 -1.618 -9.587 -10.599 1.00 97.27 C \\\\nATOM 2450 CZ PHE A 311 -1.255 -8.367 -11.190 1.00 97.27 C \\\\nATOM 2451 N CYS A 312 -1.209 -11.476 -6.173 1.00 97.36 N \\\\nATOM 2452 CA CYS A 312 0.056 -12.118 -5.839 1.00 97.36 C \\\\nATOM 2453 C CYS A 312 1.023 -12.116 -7.031 1.00 97.36 C \\\\nATOM 2454 CB CYS A 312 -0.262 -13.530 -5.345 1.00 97.36 C \\\\nATOM 2455 O CYS A 312 0.951 -12.957 -7.924 1.00 97.36 O \\\\nATOM 2456 SG CYS A 312 -0.905 -13.448 -3.650 1.00 97.36 S \\\\nATOM 2457 N LEU A 313 1.981 -11.193 -7.027 1.00 97.92 N \\\\nATOM 2458 CA LEU A 313 2.961 -11.027 -8.100 1.00 97.92 C \\\\nATOM 2459 C LEU A 313 3.986 -12.164 -8.147 1.00 97.92 C \\\\nATOM 2460 CB LEU A 313 3.682 -9.679 -7.923 1.00 97.92 C \\\\nATOM 2461 O LEU A 313 4.587 -12.400 -9.197 1.00 97.92 O \\\\nATOM 2462 CG LEU A 313 2.757 -8.448 -7.849 1.00 97.92 C \\\\nATOM 2463 CD1 LEU A 313 3.620 -7.194 -7.709 1.00 97.92 C \\\\nATOM 2464 CD2 LEU A 313 1.873 -8.320 -9.087 1.00 97.92 C \\\\nATOM 2465 N GLY A 314 4.205 -12.865 -7.030 1.00 97.10 N \\\\nATOM 2466 CA GLY A 314 5.233 -13.897 -6.866 1.00 97.10 C \\\\nATOM 2467 C GLY A 314 5.062 -15.102 -7.791 1.00 97.10 C \\\\nATOM 2468 O GLY A 314 6.067 -15.654 -8.237 1.00 97.10 O \\\\nATOM 2469 N LEU A 315 3.819 -15.453 -8.143 1.00 95.97 N \\\\nATOM 2470 CA LEU A 315 3.499 -16.566 -9.051 1.00 95.97 C \\\\nATOM 2471 C LEU A 315 3.662 -16.217 -10.539 1.00 95.97 C \\\\nATOM 2472 CB LEU A 315 2.086 -17.092 -8.729 1.00 95.97 C \\\\nATOM 2473 O LEU A 315 3.755 -17.111 -11.380 1.00 95.97 O \\\\nATOM 2474 CG LEU A 315 0.935 -16.120 -9.073 1.00 95.97 C \\\\nATOM 2475 CD1 LEU A 315 0.299 -16.433 -10.426 1.00 95.97 C \\\\nATOM 2476 CD2 LEU A 315 -0.157 -16.195 -8.008 1.00 95.97 C \\\\nATOM 2477 N LEU A 316 3.706 -14.925 -10.878 1.00 96.99 N \\\\nATOM 2478 CA LEU A 316 3.794 -14.481 -12.265 1.00 96.99 C \\\\nATOM 2479 C LEU A 316 5.173 -14.805 -12.842 1.00 96.99 C \\\\nATOM 2480 CB LEU A 316 3.471 -12.984 -12.385 1.00 96.99 C \\\\nATOM 2481 O LEU A 316 6.210 -14.418 -12.291 1.00 96.99 O \\\\nATOM 2482 CG LEU A 316 2.113 -12.561 -11.798 1.00 96.99 C \\\\nATOM 2483 CD1 LEU A 316 1.944 -11.053 -11.957 1.00 96.99 C \\\\nATOM 2484 CD2 LEU A 316 0.944 -13.261 -12.490 1.00 96.99 C \\\\nATOM 2485 N SER A 317 5.184 -15.500 -13.972 1.00 96.68 N \\\\nATOM 2486 CA SER A 317 6.404 -15.879 -14.683 1.00 96.68 C \\\\nATOM 2487 C SER A 317 6.768 -14.847 -15.747 1.00 96.68 C \\\\nATOM 2488 CB SER A 317 6.244 -17.279 -15.274 1.00 96.68 C \\\\nATOM 2489 O SER A 317 5.897 -14.247 -16.368 1.00 96.68 O \\\\nATOM 2490 OG SER A 317 6.150 -18.211 -14.215 1.00 96.68 O \\\\nATOM 2491 N ASN A 318 8.068 -14.645 -15.957 1.00 96.83 N \\\\nATOM 2492 CA ASN A 318 8.603 -13.826 -17.038 1.00 96.83 C \\\\nATOM 2493 C ASN A 318 9.930 -14.436 -17.500 1.00 96.83 C \\\\nATOM 2494 CB ASN A 318 8.779 -12.374 -16.559 1.00 96.83 C \\\\nATOM 2495 O ASN A 318 10.871 -14.531 -16.712 1.00 96.83 O \\\\nATOM 2496 CG ASN A 318 9.386 -11.484 -17.632 1.00 96.83 C \\\\nATOM 2497 ND2 ASN A 318 9.829 -10.306 -17.276 1.00 96.83 N \\\\nATOM 2498 OD1 ASN A 318 9.485 -11.850 -18.793 1.00 96.83 O \\\\nATOM 2499 N VAL A 319 10.000 -14.848 -18.766 1.00 97.17 N \\\\nATOM 2500 CA VAL A 319 11.196 -15.471 -19.359 1.00 97.17 C \\\\nATOM 2501 C VAL A 319 12.351 -14.482 -19.547 1.00 97.17 C \\\\nATOM 2502 CB VAL A 319 10.863 -16.166 -20.694 1.00 97.17 C \\\\nATOM 2503 O VAL A 319 13.506 -14.891 -19.538 1.00 97.17 O \\\\nATOM 2504 CG1 VAL A 319 9.882 -17.326 -20.475 1.00 97.17 C \\\\nATOM 2505 CG2 VAL A 319 10.269 -15.208 -21.737 1.00 97.17 C \\\\nATOM 2506 N ASN A 320 12.057 -13.181 -19.638 1.00 96.50 N \\\\nATOM 2507 CA ASN A 320 13.054 -12.117 -19.802 1.00 96.50 C \\\\nATOM 2508 C ASN A 320 13.523 -11.529 -18.459 1.00 96.50 C \\\\nATOM 2509 CB ASN A 320 12.464 -11.029 -20.705 1.00 96.50 C \\\\nATOM 2510 O ASN A 320 14.186 -10.488 -18.414 1.00 96.50 O \\\\nATOM 2511 CG ASN A 320 12.086 -11.526 -22.084 1.00 96.50 C \\\\nATOM 2512 ND2 ASN A 320 11.033 -10.985 -22.645 1.00 96.50 N \\\\nATOM 2513 OD1 ASN A 320 12.723 -12.384 -22.669 1.00 96.50 O \\\\nATOM 2514 N ARG A 321 13.147 -12.154 -17.338 1.00 97.58 N \\\\nATOM 2515 CA ARG A 321 13.455 -11.652 -16.001 1.00 97.58 C \\\\nATOM 2516 C ARG A 321 14.955 -11.720 -15.729 1.00 97.58 C \\\\nATOM 2517 CB ARG A 321 12.655 -12.456 -14.978 1.00 97.58 C \\\\nATOM 2518 O ARG A 321 15.547 -12.792 -15.714 1.00 97.58 O \\\\nATOM 2519 CG ARG A 321 12.835 -11.900 -13.562 1.00 97.58 C \\\\nATOM 2520 CD ARG A 321 11.934 -12.637 -12.575 1.00 97.58 C \\\\nATOM 2521 NE ARG A 321 10.512 -12.373 -12.857 1.00 97.58 N \\\\nATOM 2522 NH1 ARG A 321 9.606 -14.398 -12.205 1.00 97.58 N \\\\nATOM 2523 NH2 ARG A 321 8.307 -12.773 -12.966 1.00 97.58 N \\\\nATOM 2524 CZ ARG A 321 9.494 -13.189 -12.681 1.00 97.58 C \\\\nATOM 2525 N ASN A 322 15.557 -10.570 -15.437 1.00 97.73 N \\\\nATOM 2526 CA ASN A 322 16.963 -10.493 -15.040 1.00 97.73 C \\\\nATOM 2527 C ASN A 322 17.152 -10.588 -13.511 1.00 97.73 C \\\\nATOM 2528 CB ASN A 322 17.599 -9.249 -15.686 1.00 97.73 C \\\\nATOM 2529 O ASN A 322 16.209 -10.436 -12.729 1.00 97.73 O \\\\nATOM 2530 CG ASN A 322 17.151 -7.924 -15.094 1.00 97.73 C \\\\nATOM 2531 ND2 ASN A 322 16.987 -6.916 -15.913 1.00 97.73 N \\\\nATOM 2532 OD1 ASN A 322 16.995 -7.756 -13.892 1.00 97.73 O \\\\nATOM 2533 N ALA A 323 18.404 -10.758 -13.075 1.00 98.07 N \\\\nATOM 2534 CA ALA A 323 18.758 -10.909 -11.661 1.00 98.07 C \\\\nATOM 2535 C ALA A 323 18.328 -9.721 -10.772 1.00 98.07 C \\\\nATOM 2536 CB ALA A 323 20.276 -11.121 -11.582 1.00 98.07 C \\\\nATOM 2537 O ALA A 323 17.970 -9.910 -9.609 1.00 98.07 O \\\\nATOM 2538 N THR A 324 18.318 -8.489 -11.304 1.00 97.78 N \\\\nATOM 2539 CA THR A 324 17.886 -7.300 -10.543 1.00 97.78 C \\\\nATOM 2540 C THR A 324 16.382 -7.333 -10.272 1.00 97.78 C \\\\nATOM 2541 CB THR A 324 18.247 -5.996 -11.274 1.00 97.78 C \\\\nATOM 2542 O THR A 324 15.947 -7.012 -9.162 1.00 97.78 O \\\\nATOM 2543 CG2 THR A 324 17.804 -4.742 -10.517 1.00 97.78 C \\\\nATOM 2544 OG1 THR A 324 19.643 -5.883 -11.404 1.00 97.78 O \\\\nATOM 2545 N VAL A 325 15.585 -7.737 -11.264 1.00 98.29 N \\\\nATOM 2546 CA VAL A 325 14.136 -7.931 -11.116 1.00 98.29 C \\\\nATOM 2547 C VAL A 325 13.861 -9.056 -10.125 1.00 98.29 C \\\\nATOM 2548 CB VAL A 325 13.481 -8.218 -12.478 1.00 98.29 C \\\\nATOM 2549 O VAL A 325 13.096 -8.871 -9.184 1.00 98.29 O \\\\nATOM 2550 CG1 VAL A 325 11.986 -8.490 -12.319 1.00 98.29 C \\\\nATOM 2551 CG2 VAL A 325 13.630 -7.049 -13.462 1.00 98.29 C \\\\nATOM 2552 N GLU A 326 14.549 -10.189 -10.255 1.00 97.74 N \\\\nATOM 2553 CA GLU A 326 14.381 -11.326 -9.349 1.00 97.74 C \\\\nATOM 2554 C GLU A 326 14.725 -10.975 -7.890 1.00 97.74 C \\\\nATOM 2555 CB GLU A 326 15.262 -12.471 -9.852 1.00 97.74 C \\\\nATOM 2556 O GLU A 326 14.016 -11.359 -6.960 1.00 97.74 O \\\\nATOM 2557 CG GLU A 326 14.721 -13.828 -9.395 1.00 97.74 C \\\\nATOM 2558 CD GLU A 326 15.759 -14.933 -9.594 1.00 97.74 C \\\\nATOM 2559 OE1 GLU A 326 15.776 -15.832 -8.727 1.00 97.74 O \\\\nATOM 2560 OE2 GLU A 326 16.610 -14.789 -10.490 1.00 97.74 O \\\\nATOM 2561 N MET A 327 15.794 -10.209 -7.659 1.00 97.59 N \\\\nATOM 2562 CA MET A 327 16.147 -9.710 -6.327 1.00 97.59 C \\\\nATOM 2563 C MET A 327 15.103 -8.722 -5.792 1.00 97.59 C \\\\nATOM 2564 CB MET A 327 17.539 -9.070 -6.389 1.00 97.59 C \\\\nATOM 2565 O MET A 327 14.763 -8.762 -4.611 1.00 97.59 O \\\\nATOM 2566 CG MET A 327 18.035 -8.631 -5.006 1.00 97.59 C \\\\nATOM 2567 SD MET A 327 19.672 -7.856 -5.020 1.00 97.59 S \\\\nATOM 2568 CE MET A 327 20.725 -9.310 -5.290 1.00 97.59 C \\\\nATOM 2569 N THR A 328 14.567 -7.855 -6.653 1.00 98.24 N \\\\nATOM 2570 CA THR A 328 13.542 -6.872 -6.271 1.00 98.24 C \\\\nATOM 2571 C THR A 328 12.232 -7.556 -5.877 1.00 98.24 C \\\\nATOM 2572 CB THR A 328 13.318 -5.853 -7.398 1.00 98.24 C \\\\nATOM 2573 O THR A 328 11.670 -7.224 -4.836 1.00 98.24 O \\\\nATOM 2574 CG2 THR A 328 12.306 -4.781 -7.010 1.00 98.24 C \\\\nATOM 2575 OG1 THR A 328 14.542 -5.197 -7.673 1.00 98.24 O \\\\nATOM 2576 N ARG A 329 11.798 -8.577 -6.628 1.00 98.35 N \\\\nATOM 2577 CA ARG A 329 10.590 -9.370 -6.335 1.00 98.35 C \\\\nATOM 2578 C ARG A 329 10.609 -9.990 -4.937 1.00 98.35 C \\\\nATOM 2579 CB ARG A 329 10.412 -10.460 -7.402 1.00 98.35 C \\\\nATOM 2580 O ARG A 329 9.590 -9.963 -4.254 1.00 98.35 O \\\\nATOM 2581 CG ARG A 329 9.955 -9.872 -8.744 1.00 98.35 C \\\\nATOM 2582 CD ARG A 329 10.008 -10.903 -9.872 1.00 98.35 C \\\\nATOM 2583 NE ARG A 329 9.130 -12.058 -9.617 1.00 98.35 N \\\\nATOM 2584 NH1 ARG A 329 7.139 -11.118 -10.318 1.00 98.35 N \\\\nATOM 2585 NH2 ARG A 329 7.166 -13.166 -9.480 1.00 98.35 N \\\\nATOM 2586 CZ ARG A 329 7.825 -12.099 -9.806 1.00 98.35 C \\\\nATOM 2587 N ARG A 330 11.773 -10.465 -4.472 1.00 97.77 N \\\\nATOM 2588 CA ARG A 330 11.949 -11.017 -3.111 1.00 97.77 C \\\\nATOM 2589 C ARG A 330 11.653 -10.000 -2.003 1.00 97.77 C \\\\nATOM 2590 CB ARG A 330 13.377 -11.557 -2.929 1.00 97.77 C \\\\nATOM 2591 O ARG A 330 11.192 -10.388 -0.938 1.00 97.77 O \\\\nATOM 2592 CG ARG A 330 13.676 -12.800 -3.778 1.00 97.77 C \\\\nATOM 2593 CD ARG A 330 15.146 -13.199 -3.598 1.00 97.77 C \\\\nATOM 2594 NE ARG A 330 15.505 -14.389 -4.391 1.00 97.77 N \\\\nATOM 2595 NH1 ARG A 330 16.166 -13.356 -6.344 1.00 97.77 N \\\\nATOM 2596 NH2 ARG A 330 16.360 -15.551 -6.138 1.00 97.77 N \\\\nATOM 2597 CZ ARG A 330 16.011 -14.419 -5.612 1.00 97.77 C \\\\nATOM 2598 N HIS A 331 11.891 -8.714 -2.261 1.00 97.91 N \\\\nATOM 2599 CA HIS A 331 11.701 -7.631 -1.292 1.00 97.91 C \\\\nATOM 2600 C HIS A 331 10.309 -6.993 -1.356 1.00 97.91 C \\\\nATOM 2601 CB HIS A 331 12.799 -6.580 -1.485 1.00 97.91 C \\\\nATOM 2602 O HIS A 331 9.998 -6.134 -0.536 1.00 97.91 O \\\\nATOM 2603 CG HIS A 331 14.171 -7.075 -1.124 1.00 97.91 C \\\\nATOM 2604 CD2 HIS A 331 14.804 -6.915 0.079 1.00 97.91 C \\\\nATOM 2605 ND1 HIS A 331 15.028 -7.762 -1.952 1.00 97.91 N \\\\nATOM 2606 CE1 HIS A 331 16.153 -8.011 -1.265 1.00 97.91 C \\\\nATOM 2607 NE2 HIS A 331 16.067 -7.506 -0.028 1.00 97.91 N \\\\nATOM 2608 N ILE A 332 9.444 -7.410 -2.291 1.00 98.33 N \\\\nATOM 2609 CA ILE A 332 8.044 -6.968 -2.289 1.00 98.33 C \\\\nATOM 2610 C ILE A 332 7.382 -7.439 -0.989 1.00 98.33 C \\\\nATOM 2611 CB ILE A 332 7.289 -7.454 -3.548 1.00 98.33 C \\\\nATOM 2612 O ILE A 332 6.767 -6.633 -0.291 1.00 98.33 O \\\\nATOM 2613 CG1 ILE A 332 7.951 -6.868 -4.816 1.00 98.33 C \\\\nATOM 2614 CG2 ILE A 332 5.803 -7.051 -3.477 1.00 98.33 C \\\\nATOM 2615 CD1 ILE A 332 7.322 -7.321 -6.138 1.00 98.33 C \\\\nATOM 2616 N GLY A 333 7.564 -8.710 -0.613 1.00 96.97 N \\\\nATOM 2617 CA GLY A 333 7.011 -9.267 0.622 1.00 96.97 C \\\\nATOM 2618 C GLY A 333 5.499 -9.059 0.688 1.00 96.97 C \\\\nATOM 2619 O GLY A 333 4.781 -9.431 -0.234 1.00 96.97 O \\\\nATOM 2620 N ARG A 334 5.014 -8.404 1.747 1.00 96.99 N \\\\nATOM 2621 CA ARG A 334 3.590 -8.052 1.914 1.00 96.99 C \\\\nATOM 2622 C ARG A 334 3.105 -6.923 0.990 1.00 96.99 C \\\\nATOM 2623 CB ARG A 334 3.332 -7.682 3.376 1.00 96.99 C \\\\nATOM 2624 O ARG A 334 1.907 -6.669 0.949 1.00 96.99 O \\\\nATOM 2625 CG ARG A 334 3.610 -8.820 4.371 1.00 96.99 C \\\\nATOM 2626 CD ARG A 334 3.509 -8.312 5.813 1.00 96.99 C \\\\nATOM 2627 NE ARG A 334 2.156 -7.801 6.116 1.00 96.99 N \\\\nATOM 2628 NH1 ARG A 334 2.778 -6.270 7.713 1.00 96.99 N \\\\nATOM 2629 NH2 ARG A 334 0.650 -6.379 7.050 1.00 96.99 N \\\\nATOM 2630 CZ ARG A 334 1.871 -6.829 6.963 1.00 96.99 C \\\\nATOM 2631 N GLY A 335 4.019 -6.256 0.284 1.00 97.95 N \\\\nATOM 2632 CA GLY A 335 3.738 -5.303 -0.786 1.00 97.95 C \\\\nATOM 2633 C GLY A 335 2.956 -4.063 -0.355 1.00 97.95 C \\\\nATOM 2634 O GLY A 335 3.332 -3.387 0.604 1.00 97.95 O \\\\nATOM 2635 N VAL A 336 1.898 -3.735 -1.094 1.00 98.47 N \\\\nATOM 2636 CA VAL A 336 1.054 -2.552 -0.872 1.00 98.47 C \\\\nATOM 2637 C VAL A 336 -0.393 -2.973 -0.664 1.00 98.47 C \\\\nATOM 2638 CB VAL A 336 1.204 -1.522 -2.012 1.00 98.47 C \\\\nATOM 2639 O VAL A 336 -0.916 -3.807 -1.401 1.00 98.47 O \\\\nATOM 2640 CG1 VAL A 336 0.789 -2.047 -3.392 1.00 98.47 C \\\\nATOM 2641 CG2 VAL A 336 0.412 -0.237 -1.741 1.00 98.47 C \\\\nATOM 2642 N ARG A 337 -1.062 -2.375 0.322 1.00 97.58 N \\\\nATOM 2643 CA ARG A 337 -2.518 -2.443 0.435 1.00 97.58 C \\\\nATOM 2644 C ARG A 337 -3.132 -1.201 -0.182 1.00 97.58 C \\\\nATOM 2645 CB ARG A 337 -2.931 -2.656 1.887 1.00 97.58 C \\\\nATOM 2646 O ARG A 337 -2.751 -0.086 0.167 1.00 97.58 O \\\\nATOM 2647 CG ARG A 337 -4.458 -2.695 2.038 1.00 97.58 C \\\\nATOM 2648 CD ARG A 337 -4.849 -2.850 3.499 1.00 97.58 C \\\\nATOM 2649 NE ARG A 337 -4.440 -4.165 4.015 1.00 97.58 N \\\\nATOM 2650 NH1 ARG A 337 -4.005 -3.476 6.154 1.00 97.58 N \\\\nATOM 2651 NH2 ARG A 337 -4.062 -5.673 5.649 1.00 97.58 N \\\\nATOM 2652 CZ ARG A 337 -4.166 -4.427 5.272 1.00 97.58 C \\\\nATOM 2653 N LEU A 338 -4.098 -1.415 -1.063 1.00 97.59 N \\\\nATOM 2654 CA LEU A 338 -4.912 -0.367 -1.655 1.00 97.59 C \\\\nATOM 2655 C LEU A 338 -6.320 -0.481 -1.098 1.00 97.59 C \\\\nATOM 2656 CB LEU A 338 -4.897 -0.468 -3.187 1.00 97.59 C \\\\nATOM 2657 O LEU A 338 -6.879 -1.579 -1.059 1.00 97.59 O \\\\nATOM 2658 CG LEU A 338 -3.497 -0.423 -3.817 1.00 97.59 C \\\\nATOM 2659 CD1 LEU A 338 -3.606 -0.648 -5.321 1.00 97.59 C \\\\nATOM 2660 CD2 LEU A 338 -2.817 0.921 -3.570 1.00 97.59 C \\\\nATOM 2661 N TYR A 339 -6.886 0.635 -0.657 1.00 94.29 N \\\\nATOM 2662 CA TYR A 339 -8.265 0.657 -0.192 1.00 94.29 C \\\\nATOM 2663 C TYR A 339 -9.008 1.896 -0.686 1.00 94.29 C \\\\nATOM 2664 CB TYR A 339 -8.335 0.456 1.329 1.00 94.29 C \\\\nATOM 2665 O TYR A 339 -8.458 2.998 -0.687 1.00 94.29 O \\\\nATOM 2666 CG TYR A 339 -7.543 1.443 2.169 1.00 94.29 C \\\\nATOM 2667 CD1 TYR A 339 -6.210 1.165 2.529 1.00 94.29 C \\\\nATOM 2668 CD2 TYR A 339 -8.145 2.635 2.605 1.00 94.29 C \\\\nATOM 2669 CE1 TYR A 339 -5.487 2.074 3.325 1.00 94.29 C \\\\nATOM 2670 CE2 TYR A 339 -7.443 3.529 3.435 1.00 94.29 C \\\\nATOM 2671 OH TYR A 339 -5.372 4.184 4.461 1.00 94.29 O \\\\nATOM 2672 CZ TYR A 339 -6.099 3.260 3.778 1.00 94.29 C \\\\nATOM 2673 N TYR A 340 -10.252 1.677 -1.109 1.00 94.08 N \\\\nATOM 2674 CA TYR A 340 -11.198 2.666 -1.603 1.00 94.08 C \\\\nATOM 2675 C TYR A 340 -12.298 2.883 -0.566 1.00 94.08 C \\\\nATOM 2676 CB TYR A 340 -11.787 2.203 -2.940 1.00 94.08 C \\\\nATOM 2677 O TYR A 340 -13.059 1.967 -0.251 1.00 94.08 O \\\\nATOM 2678 CG TYR A 340 -12.829 3.157 -3.495 1.00 94.08 C \\\\nATOM 2679 CD1 TYR A 340 -14.131 2.706 -3.792 1.00 94.08 C \\\\nATOM 2680 CD2 TYR A 340 -12.493 4.507 -3.719 1.00 94.08 C \\\\nATOM 2681 CE1 TYR A 340 -15.084 3.595 -4.329 1.00 94.08 C \\\\nATOM 2682 CE2 TYR A 340 -13.440 5.394 -4.262 1.00 94.08 C \\\\nATOM 2683 OH TYR A 340 -15.648 5.811 -5.089 1.00 94.08 O \\\\nATOM 2684 CZ TYR A 340 -14.740 4.941 -4.572 1.00 94.08 C \\\\nATOM 2685 N ILE A 341 -12.338 4.078 0.021 1.00 89.81 N \\\\nATOM 2686 CA ILE A 341 -13.234 4.410 1.131 1.00 89.81 C \\\\nATOM 2687 C ILE A 341 -13.700 5.849 0.976 1.00 89.81 C \\\\nATOM 2688 CB ILE A 341 -12.529 4.199 2.489 1.00 89.81 C \\\\nATOM 2689 O ILE A 341 -12.882 6.758 0.866 1.00 89.81 O \\\\nATOM 2690 CG1 ILE A 341 -12.080 2.726 2.624 1.00 89.81 C \\\\nATOM 2691 CG2 ILE A 341 -13.460 4.596 3.652 1.00 89.81 C \\\\nATOM 2692 CD1 ILE A 341 -11.307 2.440 3.893 1.00 89.81 C \\\\nATOM 2693 N GLY A 342 -15.016 6.063 0.993 1.00 86.14 N \\\\nATOM 2694 CA GLY A 342 -15.597 7.405 0.992 1.00 86.14 C \\\\nATOM 2695 C GLY A 342 -15.259 8.241 -0.249 1.00 86.14 C \\\\nATOM 2696 O GLY A 342 -15.158 9.458 -0.142 1.00 86.14 O \\\\nATOM 2697 N GLY A 343 -15.028 7.616 -1.409 1.00 91.06 N \\\\nATOM 2698 CA GLY A 343 -14.581 8.324 -2.616 1.00 91.06 C \\\\nATOM 2699 C GLY A 343 -13.084 8.656 -2.634 1.00 91.06 C \\\\nATOM 2700 O GLY A 343 -12.636 9.430 -3.477 1.00 91.06 O \\\\nATOM 2701 N GLU A 344 -12.297 8.093 -1.718 1.00 95.31 N \\\\nATOM 2702 CA GLU A 344 -10.852 8.298 -1.624 1.00 95.31 C \\\\nATOM 2703 C GLU A 344 -10.106 6.972 -1.770 1.00 95.31 C \\\\nATOM 2704 CB GLU A 344 -10.482 8.970 -0.295 1.00 95.31 C \\\\nATOM 2705 O GLU A 344 -10.546 5.940 -1.260 1.00 95.31 O \\\\nATOM 2706 CG GLU A 344 -11.302 10.232 -0.002 1.00 95.31 C \\\\nATOM 2707 CD GLU A 344 -10.703 11.044 1.148 1.00 95.31 C \\\\nATOM 2708 OE1 GLU A 344 -10.492 12.263 0.951 1.00 95.31 O \\\\nATOM 2709 OE2 GLU A 344 -10.289 10.495 2.196 1.00 95.31 O \\\\nATOM 2710 N VAL A 345 -8.951 6.998 -2.437 1.00 97.02 N \\\\nATOM 2711 CA VAL A 345 -8.064 5.834 -2.562 1.00 97.02 C \\\\nATOM 2712 C VAL A 345 -6.793 6.093 -1.773 1.00 97.02 C \\\\nATOM 2713 CB VAL A 345 -7.734 5.471 -4.021 1.00 97.02 C \\\\nATOM 2714 O VAL A 345 -6.159 7.145 -1.907 1.00 97.02 O \\\\nATOM 2715 CG1 VAL A 345 -6.968 4.143 -4.103 1.00 97.02 C \\\\nATOM 2716 CG2 VAL A 345 -8.986 5.315 -4.892 1.00 97.02 C \\\\nATOM 2717 N PHE A 346 -6.380 5.106 -0.989 1.00 97.07 N \\\\nATOM 2718 CA PHE A 346 -5.151 5.148 -0.209 1.00 97.07 C \\\\nATOM 2719 C PHE A 346 -4.224 3.991 -0.574 1.00 97.07 C \\\\nATOM 2720 CB PHE A 346 -5.493 5.078 1.271 1.00 97.07 C \\\\nATOM 2721 O PHE A 346 -4.683 2.895 -0.893 1.00 97.07 O \\\\nATOM 2722 CG PHE A 346 -6.297 6.235 1.835 1.00 97.07 C \\\\nATOM 2723 CD1 PHE A 346 -5.655 7.239 2.584 1.00 97.07 C \\\\nATOM 2724 CD2 PHE A 346 -7.695 6.276 1.669 1.00 97.07 C \\\\nATOM 2725 CE1 PHE A 346 -6.405 8.281 3.159 1.00 97.07 C \\\\nATOM 2726 CE2 PHE A 346 -8.443 7.312 2.250 1.00 97.07 C \\\\nATOM 2727 CZ PHE A 346 -7.800 8.318 2.989 1.00 97.07 C \\\\nATOM 2728 N ALA A 347 -2.919 4.234 -0.463 1.00 97.96 N \\\\nATOM 2729 CA ALA A 347 -1.883 3.211 -0.516 1.00 97.96 C \\\\nATOM 2730 C ALA A 347 -1.181 3.105 0.840 1.00 97.96 C \\\\nATOM 2731 CB ALA A 347 -0.893 3.540 -1.640 1.00 97.96 C \\\\nATOM 2732 O ALA A 347 -0.631 4.091 1.324 1.00 97.96 O \\\\nATOM 2733 N GLU A 348 -1.175 1.913 1.434 1.00 97.60 N \\\\nATOM 2734 CA GLU A 348 -0.460 1.568 2.668 1.00 97.60 C \\\\nATOM 2735 C GLU A 348 0.707 0.628 2.335 1.00 97.60 C \\\\nATOM 2736 CB GLU A 348 -1.450 0.952 3.679 1.00 97.60 C \\\\nATOM 2737 O GLU A 348 0.514 -0.455 1.775 1.00 97.60 O \\\\nATOM 2738 CG GLU A 348 -0.813 0.537 5.019 1.00 97.60 C \\\\nATOM 2739 CD GLU A 348 -1.741 -0.274 5.959 1.00 97.60 C \\\\nATOM 2740 OE1 GLU A 348 -1.431 -0.329 7.170 1.00 97.60 O \\\\nATOM 2741 OE2 GLU A 348 -2.691 -0.964 5.499 1.00 97.60 O \\\\nATOM 2742 N CYS A 349 1.932 1.025 2.684 1.00 97.68 N \\\\nATOM 2743 CA CYS A 349 3.120 0.208 2.464 1.00 97.68 C \\\\nATOM 2744 C CYS A 349 3.221 -0.877 3.542 1.00 97.68 C \\\\nATOM 2745 CB CYS A 349 4.354 1.110 2.436 1.00 97.68 C \\\\nATOM 2746 O CYS A 349 3.591 -0.606 4.685 1.00 97.68 O \\\\nATOM 2747 SG CYS A 349 5.812 0.141 1.956 1.00 97.68 S \\\\nATOM 2748 N LEU A 350 2.915 -2.121 3.168 1.00 97.08 N \\\\nATOM 2749 CA LEU A 350 3.031 -3.288 4.046 1.00 97.08 C \\\\nATOM 2750 C LEU A 350 4.384 -3.999 3.924 1.00 97.08 C \\\\nATOM 2751 CB LEU A 350 1.897 -4.273 3.731 1.00 97.08 C \\\\nATOM 2752 O LEU A 350 4.718 -4.808 4.790 1.00 97.08 O \\\\nATOM 2753 CG LEU A 350 0.470 -3.734 3.912 1.00 97.08 C \\\\nATOM 2754 CD1 LEU A 350 -0.500 -4.899 3.700 1.00 97.08 C \\\\nATOM 2755 CD2 LEU A 350 0.237 -3.171 5.314 1.00 97.08 C \\\\nATOM 2756 N SER A 351 5.112 -3.742 2.837 1.00 97.55 N \\\\nATOM 2757 CA SER A 351 6.471 -4.219 2.599 1.00 97.55 C \\\\nATOM 2758 C SER A 351 7.459 -3.616 3.600 1.00 97.55 C \\\\nATOM 2759 CB SER A 351 6.889 -3.842 1.174 1.00 97.55 C \\\\nATOM 2760 O SER A 351 7.312 -2.464 4.008 1.00 97.55 O \\\\nATOM 2761 OG SER A 351 8.183 -4.338 0.888 1.00 97.55 O \\\\nATOM 2762 N ASP A 352 8.506 -4.376 3.928 1.00 97.73 N \\\\nATOM 2763 CA ASP A 352 9.672 -3.889 4.679 1.00 97.73 C \\\\nATOM 2764 C ASP A 352 10.552 -2.948 3.829 1.00 97.73 C \\\\nATOM 2765 CB ASP A 352 10.497 -5.086 5.177 1.00 97.73 C \\\\nATOM 2766 O ASP A 352 11.463 -2.295 4.335 1.00 97.73 O \\\\nATOM 2767 CG ASP A 352 9.687 -6.060 6.040 1.00 97.73 C \\\\nATOM 2768 OD1 ASP A 352 8.900 -5.590 6.891 1.00 97.73 O \\\\nATOM 2769 OD2 ASP A 352 9.822 -7.280 5.800 1.00 97.73 O \\\\nATOM 2770 N SER A 353 10.281 -2.861 2.523 1.00 97.87 N \\\\nATOM 2771 CA SER A 353 10.881 -1.908 1.590 1.00 97.87 C \\\\nATOM 2772 C SER A 353 9.872 -0.838 1.176 1.00 97.87 C \\\\nATOM 2773 CB SER A 353 11.387 -2.646 0.355 1.00 97.87 C \\\\nATOM 2774 O SER A 353 8.687 -1.110 1.029 1.00 97.87 O \\\\nATOM 2775 OG SER A 353 12.472 -3.474 0.711 1.00 97.87 O \\\\nATOM 2776 N ALA A 354 10.346 0.386 0.938 1.00 98.19 N \\\\nATOM 2777 CA ALA A 354 9.480 1.481 0.503 1.00 98.19 C \\\\nATOM 2778 C ALA A 354 8.854 1.226 -0.880 1.00 98.19 C \\\\nATOM 2779 CB ALA A 354 10.281 2.789 0.517 1.00 98.19 C \\\\nATOM 2780 O ALA A 354 9.454 0.578 -1.746 1.00 98.19 O \\\\nATOM 2781 N ILE A 355 7.686 1.826 -1.100 1.00 98.61 N \\\\nATOM 2782 CA ILE A 355 7.050 1.953 -2.416 1.00 98.61 C \\\\nATOM 2783 C ILE A 355 7.110 3.408 -2.884 1.00 98.61 C \\\\nATOM 2784 CB ILE A 355 5.617 1.375 -2.426 1.00 98.61 C \\\\nATOM 2785 O ILE A 355 7.277 4.332 -2.086 1.00 98.61 O \\\\nATOM 2786 CG1 ILE A 355 4.688 2.175 -1.494 1.00 98.61 C \\\\nATOM 2787 CG2 ILE A 355 5.653 -0.123 -2.075 1.00 98.61 C \\\\nATOM 2788 CD1 ILE A 355 3.241 1.685 -1.442 1.00 98.61 C \\\\nATOM 2789 N PHE A 356 6.994 3.616 -4.188 1.00 98.53 N \\\\nATOM 2790 CA PHE A 356 7.125 4.925 -4.823 1.00 98.53 C \\\\nATOM 2791 C PHE A 356 5.921 5.140 -5.721 1.00 98.53 C \\\\nATOM 2792 CB PHE A 356 8.440 4.970 -5.608 1.00 98.53 C \\\\nATOM 2793 O PHE A 356 5.652 4.287 -6.556 1.00 98.53 O \\\\nATOM 2794 CG PHE A 356 9.661 4.735 -4.752 1.00 98.53 C \\\\nATOM 2795 CD1 PHE A 356 10.376 5.816 -4.206 1.00 98.53 C \\\\nATOM 2796 CD2 PHE A 356 10.061 3.416 -4.470 1.00 98.53 C \\\\nATOM 2797 CE1 PHE A 356 11.488 5.562 -3.384 1.00 98.53 C \\\\nATOM 2798 CE2 PHE A 356 11.152 3.175 -3.623 1.00 98.53 C \\\\nATOM 2799 CZ PHE A 356 11.881 4.248 -3.096 1.00 98.53 C \\\\nATOM 2800 N VAL A 357 5.184 6.229 -5.533 1.00 98.21 N \\\\nATOM 2801 CA VAL A 357 3.879 6.458 -6.159 1.00 98.21 C \\\\nATOM 2802 C VAL A 357 3.912 7.739 -6.975 1.00 98.21 C \\\\nATOM 2803 CB VAL A 357 2.761 6.519 -5.101 1.00 98.21 C \\\\nATOM 2804 O VAL A 357 4.269 8.792 -6.458 1.00 98.21 O \\\\nATOM 2805 CG1 VAL A 357 1.389 6.733 -5.755 1.00 98.21 C \\\\nATOM 2806 CG2 VAL A 357 2.726 5.232 -4.262 1.00 98.21 C \\\\nATOM 2807 N GLN A 358 3.482 7.661 -8.228 1.00 98.17 N \\\\nATOM 2808 CA GLN A 358 3.169 8.813 -9.064 1.00 98.17 C \\\\nATOM 2809 C GLN A 358 1.657 8.841 -9.264 1.00 98.17 C \\\\nATOM 2810 CB GLN A 358 3.941 8.699 -10.381 1.00 98.17 C \\\\nATOM 2811 O GLN A 358 1.110 8.033 -10.017 1.00 98.17 O \\\\nATOM 2812 CG GLN A 358 3.722 9.881 -11.334 1.00 98.17 C \\\\nATOM 2813 CD GLN A 358 4.458 9.662 -12.654 1.00 98.17 C \\\\nATOM 2814 NE2 GLN A 358 5.532 10.379 -12.912 1.00 98.17 N \\\\nATOM 2815 OE1 GLN A 358 4.105 8.810 -13.458 1.00 98.17 O \\\\nATOM 2816 N SER A 359 0.989 9.755 -8.561 1.00 97.96 N \\\\nATOM 2817 CA SER A 359 -0.434 10.039 -8.743 1.00 97.96 C \\\\nATOM 2818 C SER A 359 -0.601 11.513 -9.107 1.00 97.96 C \\\\nATOM 2819 CB SER A 359 -1.239 9.712 -7.487 1.00 97.96 C \\\\nATOM 2820 O SER A 359 -0.374 12.367 -8.244 1.00 97.96 O \\\\nATOM 2821 OG SER A 359 -2.534 10.252 -7.659 1.00 97.96 O \\\\nATOM 2822 N PRO A 360 -1.021 11.832 -10.342 1.00 97.02 N \\\\nATOM 2823 CA PRO A 360 -1.266 13.212 -10.746 1.00 97.02 C \\\\nATOM 2824 C PRO A 360 -2.301 13.928 -9.861 1.00 97.02 C \\\\nATOM 2825 CB PRO A 360 -1.701 13.112 -12.207 1.00 97.02 C \\\\nATOM 2826 O PRO A 360 -2.092 15.082 -9.499 1.00 97.02 O \\\\nATOM 2827 CG PRO A 360 -0.983 11.862 -12.707 1.00 97.02 C \\\\nATOM 2828 CD PRO A 360 -1.102 10.942 -11.498 1.00 97.02 C \\\\nATOM 2829 N ASN A 361 -3.351 13.228 -9.408 1.00 97.36 N \\\\nATOM 2830 CA ASN A 361 -4.341 13.769 -8.464 1.00 97.36 C \\\\nATOM 2831 C ASN A 361 -3.713 14.156 -7.117 1.00 97.36 C \\\\nATOM 2832 CB ASN A 361 -5.472 12.738 -8.310 1.00 97.36 C \\\\nATOM 2833 O ASN A 361 -3.924 15.261 -6.622 1.00 97.36 O \\\\nATOM 2834 CG ASN A 361 -6.573 13.205 -7.372 1.00 97.36 C \\\\nATOM 2835 ND2 ASN A 361 -7.574 13.894 -7.865 1.00 97.36 N \\\\nATOM 2836 OD1 ASN A 361 -6.548 12.926 -6.183 1.00 97.36 O \\\\nATOM 2837 N CYS A 362 -2.876 13.280 -6.556 1.00 96.14 N \\\\nATOM 2838 CA CYS A 362 -2.138 13.572 -5.328 1.00 96.14 C \\\\nATOM 2839 C CYS A 362 -1.158 14.740 -5.520 1.00 96.14 C \\\\nATOM 2840 CB CYS A 362 -1.401 12.295 -4.912 1.00 96.14 C \\\\nATOM 2841 O CYS A 362 -1.072 15.621 -4.668 1.00 96.14 O \\\\nATOM 2842 SG CYS A 362 -0.540 12.518 -3.334 1.00 96.14 S \\\\nATOM 2843 N ASN A 363 -0.430 14.758 -6.637 1.00 96.49 N \\\\nATOM 2844 CA ASN A 363 0.555 15.793 -6.934 1.00 96.49 C \\\\nATOM 2845 C ASN A 363 -0.107 17.169 -7.060 1.00 96.49 C \\\\nATOM 2846 CB ASN A 363 1.332 15.387 -8.199 1.00 96.49 C \\\\nATOM 2847 O ASN A 363 0.365 18.123 -6.448 1.00 96.49 O \\\\nATOM 2848 CG ASN A 363 2.246 14.195 -7.964 1.00 96.49 C \\\\nATOM 2849 ND2 ASN A 363 2.709 13.537 -8.998 1.00 96.49 N \\\\nATOM 2850 OD1 ASN A 363 2.590 13.845 -6.847 1.00 96.49 O \\\\nATOM 2851 N GLN A 364 -1.248 17.251 -7.749 1.00 95.57 N \\\\nATOM 2852 CA GLN A 364 -2.022 18.483 -7.863 1.00 95.57 C \\\\nATOM 2853 C GLN A 364 -2.529 18.980 -6.503 1.00 95.57 C \\\\nATOM 2854 CB GLN A 364 -3.164 18.253 -8.857 1.00 95.57 C \\\\nATOM 2855 O GLN A 364 -2.400 20.168 -6.215 1.00 95.57 O \\\\nATOM 2856 CG GLN A 364 -3.989 19.528 -9.096 1.00 95.57 C \\\\nATOM 2857 CD GLN A 364 -4.957 19.385 -10.265 1.00 95.57 C \\\\nATOM 2858 NE2 GLN A 364 -5.916 20.272 -10.402 1.00 95.57 N \\\\nATOM 2859 OE1 GLN A 364 -4.870 18.483 -11.078 1.00 95.57 O \\\\nATOM 2860 N ARG A 365 -3.030 18.089 -5.632 1.00 95.41 N \\\\nATOM 2861 CA ARG A 365 -3.483 18.449 -4.273 1.00 95.41 C \\\\nATOM 2862 C ARG A 365 -2.396 19.155 -3.458 1.00 95.41 C \\\\nATOM 2863 CB ARG A 365 -3.955 17.182 -3.540 1.00 95.41 C \\\\nATOM 2864 O ARG A 365 -2.692 20.091 -2.721 1.00 95.41 O \\\\nATOM 2865 CG ARG A 365 -4.554 17.483 -2.151 1.00 95.41 C \\\\nATOM 2866 CD ARG A 365 -4.732 16.213 -1.315 1.00 95.41 C \\\\nATOM 2867 NE ARG A 365 -5.657 15.286 -1.972 1.00 95.41 N \\\\nATOM 2868 NH1 ARG A 365 -4.525 13.324 -1.744 1.00 95.41 N \\\\nATOM 2869 NH2 ARG A 365 -6.301 13.471 -3.120 1.00 95.41 N \\\\nATOM 2870 CZ ARG A 365 -5.495 14.021 -2.269 1.00 95.41 C \\\\nATOM 2871 N TYR A 366 -1.151 18.699 -3.571 1.00 94.64 N \\\\nATOM 2872 CA TYR A 366 -0.016 19.262 -2.833 1.00 94.64 C \\\\nATOM 2873 C TYR A 366 0.746 20.354 -3.601 1.00 94.64 C \\\\nATOM 2874 CB TYR A 366 0.897 18.124 -2.357 1.00 94.64 C \\\\nATOM 2875 O TYR A 366 1.752 20.850 -3.098 1.00 94.64 O \\\\nATOM 2876 CG TYR A 366 0.253 17.198 -1.339 1.00 94.64 C \\\\nATOM 2877 CD1 TYR A 366 -0.097 17.689 -0.066 1.00 94.64 C \\\\nATOM 2878 CD2 TYR A 366 0.010 15.849 -1.656 1.00 94.64 C \\\\nATOM 2879 CE1 TYR A 366 -0.699 16.839 0.883 1.00 94.64 C \\\\nATOM 2880 CE2 TYR A 366 -0.598 14.996 -0.716 1.00 94.64 C \\\\nATOM 2881 OH TYR A 366 -1.546 14.667 1.459 1.00 94.64 O \\\\nATOM 2882 CZ TYR A 366 -0.953 15.490 0.554 1.00 94.64 C \\\\nATOM 2883 N GLY A 367 0.293 20.740 -4.800 1.00 95.30 N \\\\nATOM 2884 CA GLY A 367 0.976 21.736 -5.634 1.00 95.30 C \\\\nATOM 2885 C GLY A 367 2.334 21.268 -6.168 1.00 95.30 C \\\\nATOM 2886 O GLY A 367 3.211 22.085 -6.441 1.00 95.30 O \\\\nATOM 2887 N TRP A 368 2.542 19.957 -6.288 1.00 95.17 N \\\\nATOM 2888 CA TRP A 368 3.743 19.377 -6.881 1.00 95.17 C \\\\nATOM 2889 C TRP A 368 3.590 19.216 -8.391 1.00 95.17 C \\\\nATOM 2890 CB TRP A 368 4.063 18.034 -6.218 1.00 95.17 C \\\\nATOM 2891 O TRP A 368 2.484 19.074 -8.910 1.00 95.17 O \\\\nATOM 2892 CG TRP A 368 4.353 18.072 -4.751 1.00 95.17 C \\\\nATOM 2893 CD1 TRP A 368 4.860 19.125 -4.069 1.00 95.17 C \\\\nATOM 2894 CD2 TRP A 368 4.110 17.033 -3.755 1.00 95.17 C \\\\nATOM 2895 CE2 TRP A 368 4.511 17.533 -2.480 1.00 95.17 C \\\\nATOM 2896 CE3 TRP A 368 3.550 15.737 -3.790 1.00 95.17 C \\\\nATOM 2897 NE1 TRP A 368 4.962 18.809 -2.732 1.00 95.17 N \\\\nATOM 2898 CH2 TRP A 368 3.799 15.509 -1.367 1.00 95.17 C \\\\nATOM 2899 CZ2 TRP A 368 4.378 16.786 -1.301 1.00 95.17 C \\\\nATOM 2900 CZ3 TRP A 368 3.374 14.997 -2.605 1.00 95.17 C \\\\nATOM 2901 N HIS A 369 4.722 19.151 -9.096 1.00 95.30 N \\\\nATOM 2902 CA HIS A 369 4.724 18.820 -10.518 1.00 95.30 C \\\\nATOM 2903 C HIS A 369 3.951 17.502 -10.767 1.00 95.30 C \\\\nATOM 2904 CB HIS A 369 6.175 18.730 -11.012 1.00 95.30 C \\\\nATOM 2905 O HIS A 369 4.157 16.543 -10.016 1.00 95.30 O \\\\nATOM 2906 CG HIS A 369 6.259 18.606 -12.508 1.00 95.30 C \\\\nATOM 2907 CD2 HIS A 369 6.255 19.634 -13.411 1.00 95.30 C \\\\nATOM 2908 ND1 HIS A 369 6.303 17.435 -13.227 1.00 95.30 N \\\\nATOM 2909 CE1 HIS A 369 6.308 17.747 -14.536 1.00 95.30 C \\\\nATOM 2910 NE2 HIS A 369 6.277 19.073 -14.687 1.00 95.30 N \\\\nATOM 2911 N PRO A 370 3.101 17.384 -11.811 1.00 93.40 N \\\\nATOM 2912 CA PRO A 370 2.279 16.186 -12.047 1.00 93.40 C \\\\nATOM 2913 C PRO A 370 3.077 14.876 -12.133 1.00 93.40 C \\\\nATOM 2914 CB PRO A 370 1.543 16.461 -13.362 1.00 93.40 C \\\\nATOM 2915 O PRO A 370 2.563 13.802 -11.826 1.00 93.40 O \\\\nATOM 2916 CG PRO A 370 1.414 17.981 -13.379 1.00 93.40 C \\\\nATOM 2917 CD PRO A 370 2.718 18.445 -12.736 1.00 93.40 C \\\\nATOM 2918 N ALA A 371 4.357 14.974 -12.496 1.00 94.38 N \\\\nATOM 2919 CA ALA A 371 5.297 13.861 -12.604 1.00 94.38 C \\\\nATOM 2920 C ALA A 371 5.973 13.426 -11.297 1.00 94.38 C \\\\nATOM 2921 CB ALA A 371 6.387 14.274 -13.578 1.00 94.38 C \\\\nATOM 2922 O ALA A 371 6.759 12.473 -11.329 1.00 94.38 O \\\\nATOM 2923 N THR A 372 5.744 14.139 -10.194 1.00 95.75 N \\\\nATOM 2924 CA THR A 372 6.399 13.888 -8.909 1.00 95.75 C \\\\nATOM 2925 C THR A 372 6.146 12.462 -8.433 1.00 95.75 C \\\\nATOM 2926 CB THR A 372 5.952 14.920 -7.865 1.00 95.75 C \\\\nATOM 2927 O THR A 372 5.046 11.922 -8.567 1.00 95.75 O \\\\nATOM 2928 CG2 THR A 372 6.466 14.662 -6.449 1.00 95.75 C \\\\nATOM 2929 OG1 THR A 372 6.486 16.161 -8.254 1.00 95.75 O \\\\nATOM 2930 N VAL A 373 7.196 11.851 -7.883 1.00 97.76 N \\\\nATOM 2931 CA VAL A 373 7.174 10.489 -7.352 1.00 97.76 C \\\\nATOM 2932 C VAL A 373 7.317 10.554 -5.835 1.00 97.76 C \\\\nATOM 2933 CB VAL A 373 8.270 9.626 -7.999 1.00 97.76 C \\\\nATOM 2934 O VAL A 373 8.382 10.863 -5.303 1.00 97.76 O \\\\nATOM 2935 CG1 VAL A 373 8.211 8.193 -7.461 1.00 97.76 C \\\\nATOM 2936 CG2 VAL A 373 8.108 9.574 -9.523 1.00 97.76 C \\\\nATOM 2937 N CYS A 374 6.238 10.243 -5.128 1.00 96.60 N \\\\nATOM 2938 CA CYS A 374 6.176 10.254 -3.674 1.00 96.60 C \\\\nATOM 2939 C CYS A 374 6.661 8.916 -3.110 1.00 96.60 C \\\\nATOM 2940 CB CYS A 374 4.736 10.540 -3.234 1.00 96.60 C \\\\nATOM 2941 O CYS A 374 6.140 7.856 -3.455 1.00 96.60 O \\\\nATOM 2942 SG CYS A 374 4.133 12.066 -4.000 1.00 96.60 S \\\\nATOM 2943 N LYS A 375 7.632 8.944 -2.196 1.00 97.82 N \\\\nATOM 2944 CA LYS A 375 8.061 7.751 -1.455 1.00 97.82 C \\\\nATOM 2945 C LYS A 375 7.115 7.495 -0.279 1.00 97.82 C \\\\nATOM 2946 CB LYS A 375 9.514 7.947 -1.006 1.00 97.82 C \\\\nATOM 2947 O LYS A 375 6.924 8.382 0.546 1.00 97.82 O \\\\nATOM 2948 CG LYS A 375 10.077 6.726 -0.267 1.00 97.82 C \\\\nATOM 2949 CD LYS A 375 11.522 7.007 0.156 1.00 97.82 C \\\\nATOM 2950 CE LYS A 375 12.114 5.801 0.888 1.00 97.82 C \\\\nATOM 2951 NZ LYS A 375 13.500 6.086 1.337 1.00 97.82 N \\\\nATOM 2952 N ILE A 376 6.602 6.272 -0.154 1.00 97.37 N \\\\nATOM 2953 CA ILE A 376 5.853 5.795 1.017 1.00 97.37 C \\\\nATOM 2954 C ILE A 376 6.740 4.781 1.759 1.00 97.37 C \\\\nATOM 2955 CB ILE A 376 4.485 5.196 0.624 1.00 97.37 C \\\\nATOM 2956 O ILE A 376 6.971 3.680 1.248 1.00 97.37 O \\\\nATOM 2957 CG1 ILE A 376 3.673 6.151 -0.281 1.00 97.37 C \\\\nATOM 2958 CG2 ILE A 376 3.690 4.828 1.893 1.00 97.37 C \\\\nATOM 2959 CD1 ILE A 376 2.346 5.562 -0.771 1.00 97.37 C \\\\nATOM 2960 N PRO A 377 7.299 5.143 2.929 1.00 97.58 N \\\\nATOM 2961 CA PRO A 377 8.103 4.230 3.740 1.00 97.58 C \\\\nATOM 2962 C PRO A 377 7.293 3.046 4.303 1.00 97.58 C \\\\nATOM 2963 CB PRO A 377 8.691 5.083 4.871 1.00 97.58 C \\\\nATOM 2964 O PRO A 377 6.067 3.136 4.395 1.00 97.58 O \\\\nATOM 2965 CG PRO A 377 8.623 6.511 4.334 1.00 97.58 C \\\\nATOM 2966 CD PRO A 377 7.356 6.487 3.489 1.00 97.58 C \\\\nATOM 2967 N PRO A 378 7.964 1.961 4.737 1.00 97.58 N \\\\nATOM 2968 CA PRO A 378 7.325 0.838 5.428 1.00 97.58 C \\\\nATOM 2969 C PRO A 378 6.428 1.283 6.590 1.00 97.58 C \\\\nATOM 2970 CB PRO A 378 8.480 -0.034 5.930 1.00 97.58 C \\\\nATOM 2971 O PRO A 378 6.843 2.075 7.434 1.00 97.58 O \\\\nATOM 2972 CG PRO A 378 9.568 0.224 4.894 1.00 97.58 C \\\\nATOM 2973 CD PRO A 378 9.391 1.707 4.591 1.00 97.58 C \\\\nATOM 2974 N GLY A 379 5.193 0.777 6.633 1.00 92.70 N \\\\nATOM 2975 CA GLY A 379 4.200 1.105 7.662 1.00 92.70 C \\\\nATOM 2976 C GLY A 379 3.500 2.459 7.491 1.00 92.70 C \\\\nATOM 2977 O GLY A 379 2.587 2.768 8.258 1.00 92.70 O \\\\nATOM 2978 N CYS A 380 3.885 3.268 6.500 1.00 95.04 N \\\\nATOM 2979 CA CYS A 380 3.205 4.520 6.177 1.00 95.04 C \\\\nATOM 2980 C CYS A 380 2.071 4.305 5.165 1.00 95.04 C \\\\nATOM 2981 CB CYS A 380 4.220 5.558 5.676 1.00 95.04 C \\\\nATOM 2982 O CYS A 380 2.049 3.328 4.415 1.00 95.04 O \\\\nATOM 2983 SG CYS A 380 5.459 5.922 6.954 1.00 95.04 S \\\\nATOM 2984 N ASN A 381 1.143 5.261 5.116 1.00 94.89 N \\\\nATOM 2985 CA ASN A 381 0.094 5.328 4.105 1.00 94.89 C \\\\nATOM 2986 C ASN A 381 0.009 6.730 3.486 1.00 94.89 C \\\\nATOM 2987 CB ASN A 381 -1.248 4.848 4.687 1.00 94.89 C \\\\nATOM 2988 O ASN A 381 0.466 7.703 4.085 1.00 94.89 O \\\\nATOM 2989 CG ASN A 381 -1.764 5.753 5.791 1.00 94.89 C \\\\nATOM 2990 ND2 ASN A 381 -1.454 5.453 7.031 1.00 94.89 N \\\\nATOM 2991 OD1 ASN A 381 -2.427 6.748 5.560 1.00 94.89 O \\\\nATOM 2992 N LEU A 382 -0.562 6.818 2.286 1.00 94.95 N \\\\nATOM 2993 CA LEU A 382 -0.778 8.062 1.549 1.00 94.95 C \\\\nATOM 2994 C LEU A 382 -2.145 8.028 0.863 1.00 94.95 C \\\\nATOM 2995 CB LEU A 382 0.357 8.226 0.521 1.00 94.95 C \\\\nATOM 2996 O LEU A 382 -2.516 7.012 0.275 1.00 94.95 O \\\\nATOM 2997 CG LEU A 382 0.314 9.514 -0.324 1.00 94.95 C \\\\nATOM 2998 CD1 LEU A 382 0.495 10.768 0.533 1.00 94.95 C \\\\nATOM 2999 CD2 LEU A 382 1.430 9.477 -1.368 1.00 94.95 C \\\\nATOM 3000 N LYS A 383 -2.872 9.150 0.889 1.00 96.88 N \\\\nATOM 3001 CA LYS A 383 -4.083 9.348 0.081 1.00 96.88 C \\\\nATOM 3002 C LYS A 383 -3.681 9.634 -1.363 1.00 96.88 C \\\\nATOM 3003 CB LYS A 383 -4.923 10.485 0.675 1.00 96.88 C \\\\nATOM 3004 O LYS A 383 -3.294 10.754 -1.690 1.00 96.88 O \\\\nATOM 3005 CG LYS A 383 -6.269 10.625 -0.058 1.00 96.88 C \\\\nATOM 3006 CD LYS A 383 -7.087 11.818 0.451 1.00 96.88 C \\\\nATOM 3007 CE LYS A 383 -7.420 11.669 1.938 1.00 96.88 C \\\\nATOM 3008 NZ LYS A 383 -8.317 12.746 2.405 1.00 96.88 N \\\\nATOM 3009 N ILE A 384 -3.771 8.626 -2.220 1.00 97.74 N \\\\nATOM 3010 CA ILE A 384 -3.300 8.703 -3.605 1.00 97.74 C \\\\nATOM 3011 C ILE A 384 -4.361 9.256 -4.559 1.00 97.74 C \\\\nATOM 3012 CB ILE A 384 -2.738 7.347 -4.082 1.00 97.74 C \\\\nATOM 3013 O ILE A 384 -3.991 9.710 -5.633 1.00 97.74 O \\\\nATOM 3014 CG1 ILE A 384 -3.828 6.254 -4.146 1.00 97.74 C \\\\nATOM 3015 CG2 ILE A 384 -1.557 6.924 -3.190 1.00 97.74 C \\\\nATOM 3016 CD1 ILE A 384 -3.349 4.937 -4.762 1.00 97.74 C \\\\nATOM 3017 N PHE A 385 -5.646 9.255 -4.196 1.00 97.98 N \\\\nATOM 3018 CA PHE A 385 -6.714 9.810 -5.034 1.00 97.98 C \\\\nATOM 3019 C PHE A 385 -7.903 10.309 -4.205 1.00 97.98 C \\\\nATOM 3020 CB PHE A 385 -7.190 8.749 -6.032 1.00 97.98 C \\\\nATOM 3021 O PHE A 385 -8.200 9.731 -3.159 1.00 97.98 O \\\\nATOM 3022 CG PHE A 385 -7.952 9.324 -7.205 1.00 97.98 C \\\\nATOM 3023 CD1 PHE A 385 -9.359 9.385 -7.181 1.00 97.98 C \\\\nATOM 3024 CD2 PHE A 385 -7.253 9.791 -8.333 1.00 97.98 C \\\\nATOM 3025 CE1 PHE A 385 -10.052 9.907 -8.285 1.00 97.98 C \\\\nATOM 3026 CE2 PHE A 385 -7.959 10.308 -9.432 1.00 97.98 C \\\\nATOM 3027 CZ PHE A 385 -9.358 10.352 -9.416 1.00 97.98 C \\\\nATOM 3028 N ASN A 386 -8.595 11.344 -4.681 1.00 95.89 N \\\\nATOM 3029 CA ASN A 386 -9.868 11.815 -4.134 1.00 95.89 C \\\\nATOM 3030 C ASN A 386 -10.840 12.167 -5.281 1.00 95.89 C \\\\nATOM 3031 CB ASN A 386 -9.582 12.993 -3.183 1.00 95.89 C \\\\nATOM 3032 O ASN A 386 -10.531 12.988 -6.148 1.00 95.89 O \\\\nATOM 3033 CG ASN A 386 -10.836 13.650 -2.638 1.00 95.89 C \\\\nATOM 3034 ND2 ASN A 386 -11.081 13.677 -1.353 1.00 95.89 N \\\\nATOM 3035 OD1 ASN A 386 -11.657 14.142 -3.385 1.00 95.89 O \\\\nATOM 3036 N ASN A 387 -12.028 11.554 -5.262 1.00 94.32 N \\\\nATOM 3037 CA ASN A 387 -13.050 11.721 -6.296 1.00 94.32 C \\\\nATOM 3038 C ASN A 387 -13.654 13.130 -6.338 1.00 94.32 C \\\\nATOM 3039 CB ASN A 387 -14.183 10.698 -6.083 1.00 94.32 C \\\\nATOM 3040 O ASN A 387 -14.024 13.580 -7.415 1.00 94.32 O \\\\nATOM 3041 CG ASN A 387 -13.870 9.277 -6.515 1.00 94.32 C \\\\nATOM 3042 ND2 ASN A 387 -14.802 8.374 -6.338 1.00 94.32 N \\\\nATOM 3043 OD1 ASN A 387 -12.814 8.959 -7.028 1.00 94.32 O \\\\nATOM 3044 N GLN A 388 -13.768 13.834 -5.209 1.00 93.82 N \\\\nATOM 3045 CA GLN A 388 -14.294 15.206 -5.180 1.00 93.82 C \\\\nATOM 3046 C GLN A 388 -13.327 16.188 -5.848 1.00 93.82 C \\\\nATOM 3047 CB GLN A 388 -14.558 15.666 -3.740 1.00 93.82 C \\\\nATOM 3048 O GLN A 388 -13.753 17.058 -6.602 1.00 93.82 O \\\\nATOM 3049 CG GLN A 388 -15.637 14.855 -3.015 1.00 93.82 C \\\\nATOM 3050 CD GLN A 388 -15.860 15.367 -1.596 1.00 93.82 C \\\\nATOM 3051 NE2 GLN A 388 -17.079 15.365 -1.111 1.00 93.82 N \\\\nATOM 3052 OE1 GLN A 388 -14.960 15.786 -0.891 1.00 93.82 O \\\\nATOM 3053 N GLU A 389 -12.024 16.024 -5.615 1.00 94.83 N \\\\nATOM 3054 CA GLU A 389 -10.987 16.821 -6.276 1.00 94.83 C \\\\nATOM 3055 C GLU A 389 -10.980 16.567 -7.786 1.00 94.83 C \\\\nATOM 3056 CB GLU A 389 -9.615 16.480 -5.684 1.00 94.83 C \\\\nATOM 3057 O GLU A 389 -10.916 17.509 -8.573 1.00 94.83 O \\\\nATOM 3058 CG GLU A 389 -9.465 16.962 -4.234 1.00 94.83 C \\\\nATOM 3059 CD GLU A 389 -8.200 16.419 -3.565 1.00 94.83 C \\\\nATOM 3060 OE1 GLU A 389 -8.029 16.604 -2.342 1.00 94.83 O \\\\nATOM 3061 OE2 GLU A 389 -7.391 15.714 -4.210 1.00 94.83 O \\\\nATOM 3062 N PHE A 390 -11.113 15.301 -8.197 1.00 96.24 N \\\\nATOM 3063 CA PHE A 390 -11.250 14.953 -9.609 1.00 96.24 C \\\\nATOM 3064 C PHE A 390 -12.540 15.514 -10.225 1.00 96.24 C \\\\nATOM 3065 CB PHE A 390 -11.166 13.434 -9.773 1.00 96.24 C \\\\nATOM 3066 O PHE A 390 -12.490 16.068 -11.317 1.00 96.24 O \\\\nATOM 3067 CG PHE A 390 -11.298 12.992 -11.217 1.00 96.24 C \\\\nATOM 3068 CD1 PHE A 390 -12.518 12.467 -11.688 1.00 96.24 C \\\\nATOM 3069 CD2 PHE A 390 -10.216 13.152 -12.103 1.00 96.24 C \\\\nATOM 3070 CE1 PHE A 390 -12.650 12.096 -13.038 1.00 96.24 C \\\\nATOM 3071 CE2 PHE A 390 -10.352 12.779 -13.452 1.00 96.24 C \\\\nATOM 3072 CZ PHE A 390 -11.566 12.248 -13.917 1.00 96.24 C \\\\nATOM 3073 N ALA A 391 -13.674 15.437 -9.519 1.00 94.09 N \\\\nATOM 3074 CA ALA A 391 -14.953 15.999 -9.956 1.00 94.09 C \\\\nATOM 3075 C ALA A 391 -14.858 17.504 -10.230 1.00 94.09 C \\\\nATOM 3076 CB ALA A 391 -15.999 15.773 -8.856 1.00 94.09 C \\\\nATOM 3077 O ALA A 391 -15.314 17.984 -11.267 1.00 94.09 O \\\\nATOM 3078 N ALA A 392 -14.256 18.246 -9.295 1.00 94.21 N \\\\nATOM 3079 CA ALA A 392 -14.075 19.686 -9.418 1.00 94.21 C \\\\nATOM 3080 C ALA A 392 -13.184 20.033 -10.617 1.00 94.21 C \\\\nATOM 3081 CB ALA A 392 -13.490 20.214 -8.103 1.00 94.21 C \\\\nATOM 3082 O ALA A 392 -13.516 20.936 -11.383 1.00 94.21 O \\\\nATOM 3083 N LEU A 393 -12.094 19.286 -10.811 1.00 94.52 N \\\\nATOM 3084 CA LEU A 393 -11.209 19.462 -11.958 1.00 94.52 C \\\\nATOM 3085 C LEU A 393 -11.916 19.143 -13.280 1.00 94.52 C \\\\nATOM 3086 CB LEU A 393 -9.968 18.587 -11.751 1.00 94.52 C \\\\nATOM 3087 O LEU A 393 -11.835 19.930 -14.214 1.00 94.52 O \\\\nATOM 3088 CG LEU A 393 -8.927 18.738 -12.870 1.00 94.52 C \\\\nATOM 3089 CD1 LEU A 393 -8.401 20.170 -12.984 1.00 94.52 C \\\\nATOM 3090 CD2 LEU A 393 -7.771 17.797 -12.558 1.00 94.52 C \\\\nATOM 3091 N LEU A 394 -12.662 18.038 -13.344 1.00 94.94 N \\\\nATOM 3092 CA LEU A 394 -13.439 17.651 -14.520 1.00 94.94 C \\\\nATOM 3093 C LEU A 394 -14.450 18.735 -14.906 1.00 94.94 C \\\\nATOM 3094 CB LEU A 394 -14.099 16.288 -14.237 1.00 94.94 C \\\\nATOM 3095 O LEU A 394 -14.493 19.146 -16.063 1.00 94.94 O \\\\nATOM 3096 CG LEU A 394 -14.979 15.742 -15.376 1.00 94.94 C \\\\nATOM 3097 CD1 LEU A 394 -14.211 15.600 -16.687 1.00 94.94 C \\\\nATOM 3098 CD2 LEU A 394 -15.510 14.362 -14.978 1.00 94.94 C \\\\nATOM 3099 N ALA A 395 -15.207 19.256 -13.937 1.00 93.07 N \\\\nATOM 3100 CA ALA A 395 -16.156 20.342 -14.169 1.00 93.07 C \\\\nATOM 3101 C ALA A 395 -15.480 21.632 -14.670 1.00 93.07 C \\\\nATOM 3102 CB ALA A 395 -16.929 20.587 -12.868 1.00 93.07 C \\\\nATOM 3103 O ALA A 395 -16.045 22.343 -15.498 1.00 93.07 O \\\\nATOM 3104 N GLN A 396 -14.266 21.935 -14.201 1.00 93.21 N \\\\nATOM 3105 CA GLN A 396 -13.488 23.081 -14.681 1.00 93.21 C \\\\nATOM 3106 C GLN A 396 -12.965 22.861 -16.107 1.00 93.21 C \\\\nATOM 3107 CB GLN A 396 -12.330 23.364 -13.715 1.00 93.21 C \\\\nATOM 3108 O GLN A 396 -13.097 23.755 -16.943 1.00 93.21 O \\\\nATOM 3109 CG GLN A 396 -12.817 23.965 -12.389 1.00 93.21 C \\\\nATOM 3110 CD GLN A 396 -11.714 24.049 -11.337 1.00 93.21 C \\\\nATOM 3111 NE2 GLN A 396 -12.058 24.325 -10.098 1.00 93.21 N \\\\nATOM 3112 OE1 GLN A 396 -10.531 23.896 -11.587 1.00 93.21 O \\\\nATOM 3113 N SER A 397 -12.420 21.677 -16.400 1.00 93.63 N \\\\nATOM 3114 CA SER A 397 -11.832 21.340 -17.702 1.00 93.63 C \\\\nATOM 3115 C SER A 397 -12.854 21.267 -18.834 1.00 93.63 C \\\\nATOM 3116 CB SER A 397 -11.082 20.010 -17.619 1.00 93.63 C \\\\nATOM 3117 O SER A 397 -12.492 21.547 -19.971 1.00 93.63 O \\\\nATOM 3118 OG SER A 397 -9.968 20.134 -16.755 1.00 93.63 O \\\\nATOM 3119 N VAL A 398 -14.131 20.978 -18.552 1.00 91.77 N \\\\nATOM 3120 CA VAL A 398 -15.205 21.048 -19.564 1.00 91.77 C \\\\nATOM 3121 C VAL A 398 -15.265 22.425 -20.234 1.00 91.77 C \\\\nATOM 3122 CB VAL A 398 -16.559 20.665 -18.938 1.00 91.77 C \\\\nATOM 3123 O VAL A 398 -15.428 22.509 -21.448 1.00 91.77 O \\\\nATOM 3124 CG1 VAL A 398 -17.769 21.034 -19.801 1.00 91.77 C \\\\nATOM 3125 CG2 VAL A 398 -16.616 19.149 -18.736 1.00 91.77 C \\\\nATOM 3126 N ASN A 399 -15.031 23.506 -19.484 1.00 88.71 N \\\\nATOM 3127 CA ASN A 399 -15.034 24.867 -20.034 1.00 88.71 C \\\\nATOM 3128 C ASN A 399 -13.769 25.208 -20.843 1.00 88.71 C \\\\nATOM 3129 CB ASN A 399 -15.237 25.870 -18.890 1.00 88.71 C \\\\nATOM 3130 O ASN A 399 -13.734 26.231 -21.518 1.00 88.71 O \\\\nATOM 3131 CG ASN A 399 -16.513 25.607 -18.116 1.00 88.71 C \\\\nATOM 3132 ND2 ASN A 399 -16.405 25.322 -16.841 1.00 88.71 N \\\\nATOM 3133 OD1 ASN A 399 -17.610 25.615 -18.643 1.00 88.71 O \\\\nATOM 3134 N GLN A 400 -12.726 24.377 -20.767 1.00 90.24 N \\\\nATOM 3135 CA GLN A 400 -11.464 24.554 -21.497 1.00 90.24 C \\\\nATOM 3136 C GLN A 400 -11.454 23.802 -22.840 1.00 90.24 C \\\\nATOM 3137 CB GLN A 400 -10.297 24.102 -20.607 1.00 90.24 C \\\\nATOM 3138 O GLN A 400 -10.539 23.982 -23.641 1.00 90.24 O \\\\nATOM 3139 CG GLN A 400 -10.160 24.910 -19.309 1.00 90.24 C \\\\nATOM 3140 CD GLN A 400 -9.090 24.349 -18.376 1.00 90.24 C \\\\nATOM 3141 NE2 GLN A 400 -8.996 24.853 -17.167 1.00 90.24 N \\\\nATOM 3142 OE1 GLN A 400 -8.341 23.435 -18.680 1.00 90.24 O \\\\nATOM 3143 N GLY A 401 -12.472 22.976 -23.102 1.00 89.27 N \\\\nATOM 3144 CA GLY A 401 -12.641 22.243 -24.353 1.00 89.27 C \\\\nATOM 3145 C GLY A 401 -12.207 20.776 -24.292 1.00 89.27 C \\\\nATOM 3146 O GLY A 401 -11.748 20.264 -23.271 1.00 89.27 O \\\\nATOM 3147 N PHE A 402 -12.382 20.086 -25.421 1.00 90.38 N \\\\nATOM 3148 CA PHE A 402 -12.212 18.635 -25.535 1.00 90.38 C \\\\nATOM 3149 C PHE A 402 -10.825 18.148 -25.092 1.00 90.38 C \\\\nATOM 3150 CB PHE A 402 -12.499 18.227 -26.989 1.00 90.38 C \\\\nATOM 3151 O PHE A 402 -10.730 17.192 -24.327 1.00 90.38 O \\\\nATOM 3152 CG PHE A 402 -12.438 16.732 -27.227 1.00 90.38 C \\\\nATOM 3153 CD1 PHE A 402 -11.204 16.100 -27.479 1.00 90.38 C \\\\nATOM 3154 CD2 PHE A 402 -13.615 15.964 -27.177 1.00 90.38 C \\\\nATOM 3155 CE1 PHE A 402 -11.148 14.707 -27.666 1.00 90.38 C \\\\nATOM 3156 CE2 PHE A 402 -13.560 14.573 -27.372 1.00 90.38 C \\\\nATOM 3157 CZ PHE A 402 -12.327 13.944 -27.616 1.00 90.38 C \\\\nATOM 3158 N GLU A 403 -9.752 18.816 -25.531 1.00 91.17 N \\\\nATOM 3159 CA GLU A 403 -8.376 18.393 -25.238 1.00 91.17 C \\\\nATOM 3160 C GLU A 403 -8.076 18.432 -23.734 1.00 91.17 C \\\\nATOM 3161 CB GLU A 403 -7.395 19.281 -26.026 1.00 91.17 C \\\\nATOM 3162 O GLU A 403 -7.521 17.483 -23.187 1.00 91.17 O \\\\nATOM 3163 CG GLU A 403 -5.925 18.840 -25.911 1.00 91.17 C \\\\nATOM 3164 CD GLU A 403 -5.677 17.399 -26.387 1.00 91.17 C \\\\nATOM 3165 OE1 GLU A 403 -4.748 16.760 -25.836 1.00 91.17 O \\\\nATOM 3166 OE2 GLU A 403 -6.428 16.933 -27.273 1.00 91.17 O \\\\nATOM 3167 N ALA A 404 -8.515 19.483 -23.035 1.00 92.62 N \\\\nATOM 3168 CA ALA A 404 -8.321 19.609 -21.593 1.00 92.62 C \\\\nATOM 3169 C ALA A 404 -9.007 18.472 -20.823 1.00 92.62 C \\\\nATOM 3170 CB ALA A 404 -8.858 20.971 -21.154 1.00 92.62 C \\\\nATOM 3171 O ALA A 404 -8.413 17.896 -19.912 1.00 92.62 O \\\\nATOM 3172 N VAL A 405 -10.231 18.107 -21.221 1.00 93.34 N \\\\nATOM 3173 CA VAL A 405 -10.944 16.953 -20.659 1.00 93.34 C \\\\nATOM 3174 C VAL A 405 -10.209 15.657 -21.007 1.00 93.34 C \\\\nATOM 3175 CB VAL A 405 -12.409 16.916 -21.137 1.00 93.34 C \\\\nATOM 3176 O VAL A 405 -9.949 14.849 -20.123 1.00 93.34 O \\\\nATOM 3177 CG1 VAL A 405 -13.168 15.723 -20.550 1.00 93.34 C \\\\nATOM 3178 CG2 VAL A 405 -13.171 18.174 -20.705 1.00 93.34 C \\\\nATOM 3179 N TYR A 406 -9.798 15.465 -22.260 1.00 92.37 N \\\\nATOM 3180 CA TYR A 406 -9.100 14.254 -22.696 1.00 92.37 C \\\\nATOM 3181 C TYR A 406 -7.802 14.006 -21.904 1.00 92.37 C \\\\nATOM 3182 CB TYR A 406 -8.839 14.353 -24.203 1.00 92.37 C \\\\nATOM 3183 O TYR A 406 -7.530 12.876 -21.483 1.00 92.37 O \\\\nATOM 3184 CG TYR A 406 -8.253 13.085 -24.782 1.00 92.37 C \\\\nATOM 3185 CD1 TYR A 406 -6.866 12.983 -24.999 1.00 92.37 C \\\\nATOM 3186 CD2 TYR A 406 -9.099 12.000 -25.083 1.00 92.37 C \\\\nATOM 3187 CE1 TYR A 406 -6.320 11.791 -25.513 1.00 92.37 C \\\\nATOM 3188 CE2 TYR A 406 -8.557 10.807 -25.597 1.00 92.37 C \\\\nATOM 3189 OH TYR A 406 -6.648 9.555 -26.324 1.00 92.37 O \\\\nATOM 3190 CZ TYR A 406 -7.168 10.702 -25.813 1.00 92.37 C \\\\nATOM 3191 N GLN A 407 -7.043 15.062 -21.594 1.00 92.56 N \\\\nATOM 3192 CA GLN A 407 -5.833 14.987 -20.766 1.00 92.56 C \\\\nATOM 3193 C GLN A 407 -6.097 14.491 -19.332 1.00 92.56 C \\\\nATOM 3194 CB GLN A 407 -5.140 16.361 -20.741 1.00 92.56 C \\\\nATOM 3195 O GLN A 407 -5.215 13.866 -18.729 1.00 92.56 O \\\\nATOM 3196 CG GLN A 407 -4.521 16.759 -22.093 1.00 92.56 C \\\\nATOM 3197 CD GLN A 407 -3.387 15.857 -22.554 1.00 92.56 C \\\\nATOM 3198 NE2 GLN A 407 -3.095 15.834 -23.833 1.00 92.56 N \\\\nATOM 3199 OE1 GLN A 407 -2.752 15.147 -21.784 1.00 92.56 O \\\\nATOM 3200 N LEU A 408 -7.314 14.661 -18.794 1.00 94.48 N \\\\nATOM 3201 CA LEU A 408 -7.694 14.129 -17.477 1.00 94.48 C \\\\nATOM 3202 C LEU A 408 -7.704 12.599 -17.416 1.00 94.48 C \\\\nATOM 3203 CB LEU A 408 -9.060 14.664 -17.020 1.00 94.48 C \\\\nATOM 3204 O LEU A 408 -7.690 12.040 -16.318 1.00 94.48 O \\\\nATOM 3205 CG LEU A 408 -9.156 16.186 -16.858 1.00 94.48 C \\\\nATOM 3206 CD1 LEU A 408 -10.550 16.528 -16.344 1.00 94.48 C \\\\nATOM 3207 CD2 LEU A 408 -8.130 16.720 -15.861 1.00 94.48 C \\\\nATOM 3208 N THR A 409 -7.622 11.906 -18.555 1.00 94.82 N \\\\nATOM 3209 CA THR A 409 -7.381 10.454 -18.586 1.00 94.82 C \\\\nATOM 3210 C THR A 409 -6.137 10.100 -17.766 1.00 94.82 C \\\\nATOM 3211 CB THR A 409 -7.208 9.953 -20.028 1.00 94.82 C \\\\nATOM 3212 O THR A 409 -6.144 9.133 -17.007 1.00 94.82 O \\\\nATOM 3213 CG2 THR A 409 -7.149 8.427 -20.100 1.00 94.82 C \\\\nATOM 3214 OG1 THR A 409 -8.301 10.347 -20.817 1.00 94.82 O \\\\nATOM 3215 N ARG A 410 -5.094 10.946 -17.816 1.00 93.13 N \\\\nATOM 3216 CA ARG A 410 -3.854 10.766 -17.042 1.00 93.13 C \\\\nATOM 3217 C ARG A 410 -4.078 10.857 -15.534 1.00 93.13 C \\\\nATOM 3218 CB ARG A 410 -2.806 11.807 -17.467 1.00 93.13 C \\\\nATOM 3219 O ARG A 410 -3.379 10.185 -14.784 1.00 93.13 O \\\\nATOM 3220 CG ARG A 410 -2.404 11.694 -18.945 1.00 93.13 C \\\\nATOM 3221 CD ARG A 410 -1.350 12.752 -19.299 1.00 93.13 C \\\\nATOM 3222 NE ARG A 410 -0.998 12.695 -20.728 1.00 93.13 N \\\\nATOM 3223 NH1 ARG A 410 0.238 14.644 -20.846 1.00 93.13 N \\\\nATOM 3224 NH2 ARG A 410 -0.291 13.571 -22.708 1.00 93.13 N \\\\nATOM 3225 CZ ARG A 410 -0.356 13.632 -21.409 1.00 93.13 C \\\\nATOM 3226 N MET A 411 -5.054 11.647 -15.081 1.00 94.91 N \\\\nATOM 3227 CA MET A 411 -5.395 11.753 -13.657 1.00 94.91 C \\\\nATOM 3228 C MET A 411 -5.948 10.439 -13.107 1.00 94.91 C \\\\nATOM 3229 CB MET A 411 -6.416 12.876 -13.415 1.00 94.91 C \\\\nATOM 3230 O MET A 411 -5.793 10.166 -11.920 1.00 94.91 O \\\\nATOM 3231 CG MET A 411 -5.905 14.262 -13.817 1.00 94.91 C \\\\nATOM 3232 SD MET A 411 -4.534 14.885 -12.816 1.00 94.91 S \\\\nATOM 3233 CE MET A 411 -5.412 15.315 -11.297 1.00 94.91 C \\\\nATOM 3234 N CYS A 412 -6.558 9.620 -13.965 1.00 96.87 N \\\\nATOM 3235 CA CYS A 412 -7.174 8.354 -13.588 1.00 96.87 C \\\\nATOM 3236 C CYS A 412 -6.182 7.176 -13.543 1.00 96.87 C \\\\nATOM 3237 CB CYS A 412 -8.323 8.061 -14.551 1.00 96.87 C \\\\nATOM 3238 O CYS A 412 -6.571 6.071 -13.153 1.00 96.87 O \\\\nATOM 3239 SG CYS A 412 -9.484 9.454 -14.693 1.00 96.87 S \\\\nATOM 3240 N THR A 413 -4.917 7.407 -13.918 1.00 97.46 N \\\\nATOM 3241 CA THR A 413 -3.845 6.408 -13.909 1.00 97.46 C \\\\nATOM 3242 C THR A 413 -2.819 6.731 -12.826 1.00 97.46 C \\\\nATOM 3243 CB THR A 413 -3.174 6.281 -15.284 1.00 97.46 C \\\\nATOM 3244 O THR A 413 -2.224 7.807 -12.805 1.00 97.46 O \\\\nATOM 3245 CG2 THR A 413 -2.057 5.237 -15.300 1.00 97.46 C \\\\nATOM 3246 OG1 THR A 413 -4.123 5.875 -16.241 1.00 97.46 O \\\\nATOM 3247 N ILE A 414 -2.566 5.773 -11.934 1.00 98.40 N \\\\nATOM 3248 CA ILE A 414 -1.571 5.888 -10.861 1.00 98.40 C \\\\nATOM 3249 C ILE A 414 -0.518 4.805 -11.048 1.00 98.40 C \\\\nATOM 3250 CB ILE A 414 -2.229 5.818 -9.466 1.00 98.40 C \\\\nATOM 3251 O ILE A 414 -0.847 3.631 -11.200 1.00 98.40 O \\\\nATOM 3252 CG1 ILE A 414 -3.288 6.932 -9.308 1.00 98.40 C \\\\nATOM 3253 CG2 ILE A 414 -1.145 5.904 -8.372 1.00 98.40 C \\\\nATOM 3254 CD1 ILE A 414 -4.102 6.848 -8.014 1.00 98.40 C \\\\nATOM 3255 N ARG A 415 0.762 5.174 -10.987 1.00 98.53 N \\\\nATOM 3256 CA ARG A 415 1.872 4.219 -11.121 1.00 98.53 C \\\\nATOM 3257 C ARG A 415 2.588 4.041 -9.800 1.00 98.53 C \\\\nATOM 3258 CB ARG A 415 2.820 4.644 -12.244 1.00 98.53 C \\\\nATOM 3259 O ARG A 415 2.842 5.023 -9.102 1.00 98.53 O \\\\nATOM 3260 CG ARG A 415 2.070 4.671 -13.580 1.00 98.53 C \\\\nATOM 3261 CD ARG A 415 3.027 4.946 -14.731 1.00 98.53 C \\\\nATOM 3262 NE ARG A 415 2.281 4.998 -15.992 1.00 98.53 N \\\\nATOM 3263 NH1 ARG A 415 2.570 7.221 -16.554 1.00 98.53 N \\\\nATOM 3264 NH2 ARG A 415 1.353 5.820 -17.837 1.00 98.53 N \\\\nATOM 3265 CZ ARG A 415 2.087 6.027 -16.786 1.00 98.53 C \\\\nATOM 3266 N MET A 416 2.925 2.800 -9.456 1.00 98.54 N \\\\nATOM 3267 CA MET A 416 3.635 2.491 -8.216 1.00 98.54 C \\\\nATOM 3268 C MET A 416 4.779 1.514 -8.450 1.00 98.54 C \\\\nATOM 3269 CB MET A 416 2.700 1.961 -7.119 1.00 98.54 C \\\\nATOM 3270 O MET A 416 4.558 0.423 -8.959 1.00 98.54 O \\\\nATOM 3271 CG MET A 416 1.465 2.837 -6.929 1.00 98.54 C \\\\nATOM 3272 SD MET A 416 0.417 2.357 -5.534 1.00 98.54 S \\\\nATOM 3273 CE MET A 416 -1.180 2.527 -6.374 1.00 98.54 C \\\\nATOM 3274 N SER A 417 5.989 1.874 -8.031 1.00 98.68 N \\\\nATOM 3275 CA SER A 417 7.156 0.987 -8.055 1.00 98.68 C \\\\nATOM 3276 C SER A 417 7.431 0.411 -6.673 1.00 98.68 C \\\\nATOM 3277 CB SER A 417 8.388 1.709 -8.591 1.00 98.68 C \\\\nATOM 3278 O SER A 417 7.337 1.110 -5.659 1.00 98.68 O \\\\nATOM 3279 OG SER A 417 9.519 0.869 -8.532 1.00 98.68 O \\\\nATOM 3280 N PHE A 418 7.828 -0.858 -6.638 1.00 98.70 N \\\\nATOM 3281 CA PHE A 418 8.259 -1.538 -5.425 1.00 98.70 C \\\\nATOM 3282 C PHE A 418 9.772 -1.417 -5.254 1.00 98.70 C \\\\nATOM 3283 CB PHE A 418 7.837 -3.009 -5.470 1.00 98.70 C \\\\nATOM 3284 O PHE A 418 10.532 -1.666 -6.191 1.00 98.70 O \\\\nATOM 3285 CG PHE A 418 6.342 -3.225 -5.552 1.00 98.70 C \\\\nATOM 3286 CD1 PHE A 418 5.569 -3.241 -4.376 1.00 98.70 C \\\\nATOM 3287 CD2 PHE A 418 5.721 -3.406 -6.801 1.00 98.70 C \\\\nATOM 3288 CE1 PHE A 418 4.181 -3.446 -4.448 1.00 98.70 C \\\\nATOM 3289 CE2 PHE A 418 4.333 -3.607 -6.870 1.00 98.70 C \\\\nATOM 3290 CZ PHE A 418 3.561 -3.627 -5.696 1.00 98.70 C \\\\nATOM 3291 N VAL A 419 10.227 -1.120 -4.030 1.00 98.25 N \\\\nATOM 3292 CA VAL A 419 11.637 -1.131 -3.584 1.00 98.25 C \\\\nATOM 3293 C VAL A 419 12.523 -0.048 -4.215 1.00 98.25 C \\\\nATOM 3294 CB VAL A 419 12.276 -2.522 -3.799 1.00 98.25 C \\\\nATOM 3295 O VAL A 419 13.370 0.525 -3.529 1.00 98.25 O \\\\nATOM 3296 CG1 VAL A 419 13.640 -2.667 -3.112 1.00 98.25 C \\\\nATOM 3297 CG2 VAL A 419 11.402 -3.700 -3.340 1.00 98.25 C \\\\nATOM 3298 N LYS A 420 12.376 0.248 -5.511 1.00 97.93 N \\\\nATOM 3299 CA LYS A 420 13.226 1.176 -6.269 1.00 97.93 C \\\\nATOM 3300 C LYS A 420 12.432 2.405 -6.714 1.00 97.93 C \\\\nATOM 3301 CB LYS A 420 13.845 0.453 -7.483 1.00 97.93 C \\\\nATOM 3302 O LYS A 420 11.447 2.270 -7.432 1.00 97.93 O \\\\nATOM 3303 CG LYS A 420 14.640 -0.827 -7.164 1.00 97.93 C \\\\nATOM 3304 CD LYS A 420 15.786 -0.620 -6.162 1.00 97.93 C \\\\nATOM 3305 CE LYS A 420 16.542 -1.940 -5.960 1.00 97.93 C \\\\nATOM 3306 NZ LYS A 420 17.556 -1.843 -4.877 1.00 97.93 N \\\\nATOM 3307 N GLY A 421 12.905 3.593 -6.345 1.00 96.38 N \\\\nATOM 3308 CA GLY A 421 12.352 4.863 -6.819 1.00 96.38 C \\\\nATOM 3309 C GLY A 421 12.787 5.220 -8.239 1.00 96.38 C \\\\nATOM 3310 O GLY A 421 13.769 4.675 -8.761 1.00 96.38 O \\\\nATOM 3311 N TRP A 422 12.042 6.146 -8.838 1.00 98.03 N \\\\nATOM 3312 CA TRP A 422 12.339 6.792 -10.116 1.00 98.03 C \\\\nATOM 3313 C TRP A 422 11.929 8.271 -10.069 1.00 98.03 C \\\\nATOM 3314 CB TRP A 422 11.632 6.065 -11.270 1.00 98.03 C \\\\nATOM 3315 O TRP A 422 11.267 8.695 -9.122 1.00 98.03 O \\\\nATOM 3316 CG TRP A 422 10.193 6.426 -11.478 1.00 98.03 C \\\\nATOM 3317 CD1 TRP A 422 9.735 7.303 -12.401 1.00 98.03 C \\\\nATOM 3318 CD2 TRP A 422 9.016 5.985 -10.737 1.00 98.03 C \\\\nATOM 3319 CE2 TRP A 422 7.867 6.612 -11.307 1.00 98.03 C \\\\nATOM 3320 CE3 TRP A 422 8.800 5.122 -9.642 1.00 98.03 C \\\\nATOM 3321 NE1 TRP A 422 8.363 7.409 -12.311 1.00 98.03 N \\\\nATOM 3322 CH2 TRP A 422 6.387 5.528 -9.740 1.00 98.03 C \\\\nATOM 3323 CZ2 TRP A 422 6.571 6.373 -10.842 1.00 98.03 C \\\\nATOM 3324 CZ3 TRP A 422 7.500 4.913 -9.146 1.00 98.03 C \\\\nATOM 3325 N GLY A 423 12.309 9.041 -11.083 1.00 94.75 N \\\\nATOM 3326 CA GLY A 423 12.044 10.475 -11.190 1.00 94.75 C \\\\nATOM 3327 C GLY A 423 13.250 11.323 -10.786 1.00 94.75 C \\\\nATOM 3328 O GLY A 423 14.344 10.795 -10.600 1.00 94.75 O \\\\nATOM 3329 N ALA A 424 13.032 12.634 -10.641 1.00 90.85 N \\\\nATOM 3330 CA ALA A 424 14.086 13.644 -10.487 1.00 90.85 C \\\\nATOM 3331 C ALA A 424 15.119 13.325 -9.386 1.00 90.85 C \\\\nATOM 3332 CB ALA A 424 13.394 14.987 -10.215 1.00 90.85 C \\\\nATOM 3333 O ALA A 424 16.310 13.545 -9.571 1.00 90.85 O \\\\nATOM 3334 N GLU A 425 14.673 12.721 -8.282 1.00 88.72 N \\\\nATOM 3335 CA GLU A 425 15.503 12.405 -7.109 1.00 88.72 C \\\\nATOM 3336 C GLU A 425 16.249 11.058 -7.203 1.00 88.72 C \\\\nATOM 3337 CB GLU A 425 14.613 12.434 -5.855 1.00 88.72 C \\\\nATOM 3338 O GLU A 425 16.893 10.619 -6.248 1.00 88.72 O \\\\nATOM 3339 CG GLU A 425 13.885 13.769 -5.639 1.00 88.72 C \\\\nATOM 3340 CD GLU A 425 14.850 14.961 -5.596 1.00 88.72 C \\\\nATOM 3341 OE1 GLU A 425 14.500 15.996 -6.201 1.00 88.72 O \\\\nATOM 3342 OE2 GLU A 425 15.920 14.809 -4.965 1.00 88.72 O \\\\nATOM 3343 N TYR A 426 16.141 10.341 -8.325 1.00 94.62 N \\\\nATOM 3344 CA TYR A 426 16.680 8.990 -8.470 1.00 94.62 C \\\\nATOM 3345 C TYR A 426 17.466 8.829 -9.770 1.00 94.62 C \\\\nATOM 3346 CB TYR A 426 15.548 7.953 -8.380 1.00 94.62 C \\\\nATOM 3347 O TYR A 426 17.192 9.450 -10.787 1.00 94.62 O \\\\nATOM 3348 CG TYR A 426 14.758 7.996 -7.084 1.00 94.62 C \\\\nATOM 3349 CD1 TYR A 426 15.210 7.314 -5.935 1.00 94.62 C \\\\nATOM 3350 CD2 TYR A 426 13.601 8.790 -7.013 1.00 94.62 C \\\\nATOM 3351 CE1 TYR A 426 14.518 7.457 -4.715 1.00 94.62 C \\\\nATOM 3352 CE2 TYR A 426 12.900 8.928 -5.804 1.00 94.62 C \\\\nATOM 3353 OH TYR A 426 12.775 8.538 -3.454 1.00 94.62 O \\\\nATOM 3354 CZ TYR A 426 13.380 8.292 -4.645 1.00 94.62 C \\\\nATOM 3355 N ARG A 427 18.413 7.880 -9.782 1.00 94.90 N \\\\nATOM 3356 CA ARG A 427 19.152 7.509 -11.005 1.00 94.90 C \\\\nATOM 3357 C ARG A 427 18.225 7.072 -12.151 1.00 94.90 C \\\\nATOM 3358 CB ARG A 427 20.176 6.414 -10.660 1.00 94.90 C \\\\nATOM 3359 O ARG A 427 18.559 7.251 -13.317 1.00 94.90 O \\\\nATOM 3360 CG ARG A 427 21.004 5.978 -11.879 1.00 94.90 C \\\\nATOM 3361 CD ARG A 427 22.040 4.915 -11.509 1.00 94.90 C \\\\nATOM 3362 NE ARG A 427 22.699 4.393 -12.720 1.00 94.90 N \\\\nATOM 3363 NH1 ARG A 427 23.904 2.705 -11.734 1.00 94.90 N \\\\nATOM 3364 NH2 ARG A 427 24.039 3.017 -13.941 1.00 94.90 N \\\\nATOM 3365 CZ ARG A 427 23.540 3.376 -12.793 1.00 94.90 C \\\\nATOM 3366 N ARG A 428 17.099 6.434 -11.823 1.00 96.14 N \\\\nATOM 3367 CA ARG A 428 16.100 5.985 -12.799 1.00 96.14 C \\\\nATOM 3368 C ARG A 428 15.198 7.158 -13.132 1.00 96.14 C \\\\nATOM 3369 CB ARG A 428 15.268 4.838 -12.216 1.00 96.14 C \\\\nATOM 3370 O ARG A 428 14.451 7.585 -12.263 1.00 96.14 O \\\\nATOM 3371 CG ARG A 428 16.093 3.561 -12.091 1.00 96.14 C \\\\nATOM 3372 CD ARG A 428 15.265 2.482 -11.392 1.00 96.14 C \\\\nATOM 3373 NE ARG A 428 16.005 1.210 -11.355 1.00 96.14 N \\\\nATOM 3374 NH1 ARG A 428 17.371 1.723 -9.587 1.00 96.14 N \\\\nATOM 3375 NH2 ARG A 428 17.678 -0.190 -10.713 1.00 96.14 N \\\\nATOM 3376 CZ ARG A 428 17.010 0.917 -10.552 1.00 96.14 C \\\\nATOM 3377 N GLN A 429 15.240 7.633 -14.370 1.00 95.89 N \\\\nATOM 3378 CA GLN A 429 14.371 8.733 -14.772 1.00 95.89 C \\\\nATOM 3379 C GLN A 429 12.954 8.245 -15.040 1.00 95.89 C \\\\nATOM 3380 CB GLN A 429 14.980 9.512 -15.947 1.00 95.89 C \\\\nATOM 3381 O GLN A 429 12.033 8.853 -14.522 1.00 95.89 O \\\\nATOM 3382 CG GLN A 429 16.301 10.202 -15.553 1.00 95.89 C \\\\nATOM 3383 CD GLN A 429 16.155 11.065 -14.298 1.00 95.89 C \\\\nATOM 3384 NE2 GLN A 429 17.031 10.926 -13.331 1.00 95.89 N \\\\nATOM 3385 OE1 GLN A 429 15.202 11.803 -14.129 1.00 95.89 O \\\\nATOM 3386 N THR A 430 12.769 7.111 -15.726 1.00 96.48 N \\\\nATOM 3387 CA THR A 430 11.447 6.572 -16.089 1.00 96.48 C \\\\nATOM 3388 C THR A 430 10.968 5.455 -15.162 1.00 96.48 C \\\\nATOM 3389 CB THR A 430 11.421 6.056 -17.537 1.00 96.48 C \\\\nATOM 3390 O THR A 430 11.773 4.695 -14.610 1.00 96.48 O \\\\nATOM 3391 CG2 THR A 430 11.843 7.080 -18.590 1.00 96.48 C \\\\nATOM 3392 OG1 THR A 430 12.267 4.932 -17.662 1.00 96.48 O \\\\nATOM 3393 N VAL A 431 9.646 5.283 -15.053 1.00 97.27 N \\\\nATOM 3394 CA VAL A 431 9.054 4.138 -14.332 1.00 97.27 C \\\\nATOM 3395 C VAL A 431 9.428 2.805 -14.989 1.00 97.27 C \\\\nATOM 3396 CB VAL A 431 7.529 4.293 -14.205 1.00 97.27 C \\\\nATOM 3397 O VAL A 431 9.712 1.830 -14.299 1.00 97.27 O \\\\nATOM 3398 CG1 VAL A 431 6.798 4.130 -15.543 1.00 97.27 C \\\\nATOM 3399 CG2 VAL A 431 6.972 3.310 -13.171 1.00 97.27 C \\\\nATOM 3400 N THR A 432 9.565 2.786 -16.317 1.00 97.83 N \\\\nATOM 3401 CA THR A 432 9.991 1.622 -17.112 1.00 97.83 C \\\\nATOM 3402 C THR A 432 11.432 1.181 -16.834 1.00 97.83 C \\\\nATOM 3403 CB THR A 432 9.828 1.917 -18.611 1.00 97.83 C \\\\nATOM 3404 O THR A 432 11.830 0.084 -17.210 1.00 97.83 O \\\\nATOM 3405 CG2 THR A 432 8.359 2.070 -19.004 1.00 97.83 C \\\\nATOM 3406 OG1 THR A 432 10.470 3.129 -18.958 1.00 97.83 O \\\\nATOM 3407 N SER A 433 12.220 1.998 -16.126 1.00 97.46 N \\\\nATOM 3408 CA SER A 433 13.549 1.621 -15.624 1.00 97.46 C \\\\nATOM 3409 C SER A 433 13.496 0.910 -14.263 1.00 97.46 C \\\\nATOM 3410 CB SER A 433 14.424 2.869 -15.505 1.00 97.46 C \\\\nATOM 3411 O SER A 433 14.527 0.454 -13.744 1.00 97.46 O \\\\nATOM 3412 OG SER A 433 14.595 3.524 -16.742 1.00 97.46 O \\\\nATOM 3413 N THR A 434 12.325 0.861 -13.621 1.00 98.11 N \\\\nATOM 3414 CA THR A 434 12.142 0.204 -12.325 1.00 98.11 C \\\\nATOM 3415 C THR A 434 11.928 -1.301 -12.509 1.00 98.11 C \\\\nATOM 3416 CB THR A 434 11.031 0.812 -11.463 1.00 98.11 C \\\\nATOM 3417 O THR A 434 11.259 -1.723 -13.452 1.00 98.11 O \\\\nATOM 3418 CG2 THR A 434 11.186 2.317 -11.262 1.00 98.11 C \\\\nATOM 3419 OG1 THR A 434 9.764 0.546 -11.980 1.00 98.11 O \\\\nATOM 3420 N PRO A 435 12.504 -2.154 -11.642 1.00 98.30 N \\\\nATOM 3421 CA PRO A 435 12.450 -3.596 -11.871 1.00 98.30 C \\\\nATOM 3422 C PRO A 435 11.050 -4.194 -11.694 1.00 98.30 C \\\\nATOM 3423 CB PRO A 435 13.442 -4.209 -10.878 1.00 98.30 C \\\\nATOM 3424 O PRO A 435 10.746 -5.203 -12.319 1.00 98.30 O \\\\nATOM 3425 CG PRO A 435 14.335 -3.047 -10.462 1.00 98.30 C \\\\nATOM 3426 CD PRO A 435 13.396 -1.854 -10.532 1.00 98.30 C \\\\nATOM 3427 N CYS A 436 10.221 -3.614 -10.823 1.00 98.65 N \\\\nATOM 3428 CA CYS A 436 8.884 -4.108 -10.502 1.00 98.65 C \\\\nATOM 3429 C CYS A 436 7.965 -2.926 -10.214 1.00 98.65 C \\\\nATOM 3430 CB CYS A 436 8.944 -5.000 -9.249 1.00 98.65 C \\\\nATOM 3431 O CYS A 436 8.176 -2.221 -9.224 1.00 98.65 O \\\\nATOM 3432 SG CYS A 436 10.042 -6.419 -9.493 1.00 98.65 S \\\\nATOM 3433 N TRP A 437 6.930 -2.745 -11.023 1.00 98.76 N \\\\nATOM 3434 CA TRP A 437 5.951 -1.685 -10.817 1.00 98.76 C \\\\nATOM 3435 C TRP A 437 4.570 -2.099 -11.314 1.00 98.76 C \\\\nATOM 3436 CB TRP A 437 6.443 -0.390 -11.475 1.00 98.76 C \\\\nATOM 3437 O TRP A 437 4.419 -3.065 -12.058 1.00 98.76 O \\\\nATOM 3438 CG TRP A 437 6.614 -0.447 -12.954 1.00 98.76 C \\\\nATOM 3439 CD1 TRP A 437 7.657 -1.001 -13.607 1.00 98.76 C \\\\nATOM 3440 CD2 TRP A 437 5.717 0.067 -13.983 1.00 98.76 C \\\\nATOM 3441 CE2 TRP A 437 6.302 -0.203 -15.253 1.00 98.76 C \\\\nATOM 3442 CE3 TRP A 437 4.477 0.739 -13.970 1.00 98.76 C \\\\nATOM 3443 NE1 TRP A 437 7.475 -0.852 -14.960 1.00 98.76 N \\\\nATOM 3444 CH2 TRP A 437 4.433 0.768 -16.408 1.00 98.76 C \\\\nATOM 3445 CZ2 TRP A 437 5.676 0.125 -16.457 1.00 98.76 C \\\\nATOM 3446 CZ3 TRP A 437 3.846 1.096 -15.175 1.00 98.76 C \\\\nATOM 3447 N ILE A 438 3.554 -1.388 -10.843 1.00 98.75 N \\\\nATOM 3448 CA ILE A 438 2.160 -1.576 -11.224 1.00 98.75 C \\\\nATOM 3449 C ILE A 438 1.571 -0.277 -11.759 1.00 98.75 C \\\\nATOM 3450 CB ILE A 438 1.303 -2.146 -10.072 1.00 98.75 C \\\\nATOM 3451 O ILE A 438 1.939 0.818 -11.324 1.00 98.75 O \\\\nATOM 3452 CG1 ILE A 438 1.413 -1.301 -8.783 1.00 98.75 C \\\\nATOM 3453 CG2 ILE A 438 1.664 -3.623 -9.848 1.00 98.75 C \\\\nATOM 3454 CD1 ILE A 438 0.412 -1.684 -7.687 1.00 98.75 C \\\\nATOM 3455 N GLU A 439 0.626 -0.425 -12.674 1.00 98.66 N \\\\nATOM 3456 CA GLU A 439 -0.226 0.638 -13.185 1.00 98.66 C \\\\nATOM 3457 C GLU A 439 -1.659 0.385 -12.722 1.00 98.66 C \\\\nATOM 3458 CB GLU A 439 -0.113 0.684 -14.711 1.00 98.66 C \\\\nATOM 3459 O GLU A 439 -2.210 -0.693 -12.943 1.00 98.66 O \\\\nATOM 3460 CG GLU A 439 -0.773 1.930 -15.307 1.00 98.66 C \\\\nATOM 3461 CD GLU A 439 -0.329 2.117 -16.764 1.00 98.66 C \\\\nATOM 3462 OE1 GLU A 439 -0.586 1.190 -17.567 1.00 98.66 O \\\\nATOM 3463 OE2 GLU A 439 0.372 3.136 -17.029 1.00 98.66 O \\\\nATOM 3464 N LEU A 440 -2.231 1.368 -12.034 1.00 98.22 N \\\\nATOM 3465 CA LEU A 440 -3.578 1.347 -11.491 1.00 98.22 C \\\\nATOM 3466 C LEU A 440 -4.466 2.258 -12.334 1.00 98.22 C \\\\nATOM 3467 CB LEU A 440 -3.521 1.826 -10.023 1.00 98.22 C \\\\nATOM 3468 O LEU A 440 -4.170 3.444 -12.452 1.00 98.22 O \\\\nATOM 3469 CG LEU A 440 -4.725 1.370 -9.189 1.00 98.22 C \\\\nATOM 3470 CD1 LEU A 440 -4.507 -0.084 -8.800 1.00 98.22 C \\\\nATOM 3471 CD2 LEU A 440 -4.859 2.179 -7.899 1.00 98.22 C \\\\nATOM 3472 N HIS A 441 -5.560 1.729 -12.870 1.00 98.13 N \\\\nATOM 3473 CA HIS A 441 -6.609 2.516 -13.522 1.00 98.13 C \\\\nATOM 3474 C HIS A 441 -7.832 2.593 -12.619 1.00 98.13 C \\\\nATOM 3475 CB HIS A 441 -6.971 1.905 -14.878 1.00 98.13 C \\\\nATOM 3476 O HIS A 441 -8.337 1.558 -12.183 1.00 98.13 O \\\\nATOM 3477 CG HIS A 441 -5.885 1.987 -15.917 1.00 98.13 C \\\\nATOM 3478 CD2 HIS A 441 -4.763 2.768 -15.870 1.00 98.13 C \\\\nATOM 3479 ND1 HIS A 441 -5.880 1.348 -17.135 1.00 98.13 N \\\\nATOM 3480 CE1 HIS A 441 -4.779 1.739 -17.802 1.00 98.13 C \\\\nATOM 3481 NE2 HIS A 441 -4.070 2.613 -17.069 1.00 98.13 N \\\\nATOM 3482 N LEU A 442 -8.298 3.808 -12.333 1.00 97.65 N \\\\nATOM 3483 CA LEU A 442 -9.493 4.052 -11.528 1.00 97.65 C \\\\nATOM 3484 C LEU A 442 -10.723 4.098 -12.435 1.00 97.65 C \\\\nATOM 3485 CB LEU A 442 -9.317 5.340 -10.712 1.00 97.65 C \\\\nATOM 3486 O LEU A 442 -10.966 5.081 -13.135 1.00 97.65 O \\\\nATOM 3487 CG LEU A 442 -8.113 5.327 -9.756 1.00 97.65 C \\\\nATOM 3488 CD1 LEU A 442 -8.076 6.651 -9.009 1.00 97.65 C \\\\nATOM 3489 CD2 LEU A 442 -8.185 4.200 -8.722 1.00 97.65 C \\\\nATOM 3490 N ASN A 443 -11.505 3.022 -12.414 1.00 96.77 N \\\\nATOM 3491 CA ASN A 443 -12.575 2.797 -13.384 1.00 96.77 C \\\\nATOM 3492 C ASN A 443 -13.730 3.790 -13.230 1.00 96.77 C \\\\nATOM 3493 CB ASN A 443 -13.079 1.359 -13.224 1.00 96.77 C \\\\nATOM 3494 O ASN A 443 -14.340 4.164 -14.223 1.00 96.77 O \\\\nATOM 3495 CG ASN A 443 -12.053 0.308 -13.601 1.00 96.77 C \\\\nATOM 3496 ND2 ASN A 443 -12.176 -0.876 -13.059 1.00 96.77 N \\\\nATOM 3497 OD1 ASN A 443 -11.132 0.524 -14.365 1.00 96.77 O \\\\nATOM 3498 N GLY A 444 -14.029 4.226 -12.003 1.00 94.54 N \\\\nATOM 3499 CA GLY A 444 -15.098 5.191 -11.745 1.00 94.54 C \\\\nATOM 3500 C GLY A 444 -14.801 6.553 -12.378 1.00 94.54 C \\\\nATOM 3501 O GLY A 444 -15.563 7.000 -13.235 1.00 94.54 O \\\\nATOM 3502 N PRO A 445 -13.667 7.192 -12.030 1.00 95.57 N \\\\nATOM 3503 CA PRO A 445 -13.183 8.395 -12.703 1.00 95.57 C \\\\nATOM 3504 C PRO A 445 -13.102 8.266 -14.232 1.00 95.57 C \\\\nATOM 3505 CB PRO A 445 -11.812 8.667 -12.076 1.00 95.57 C \\\\nATOM 3506 O PRO A 445 -13.582 9.157 -14.930 1.00 95.57 O \\\\nATOM 3507 CG PRO A 445 -11.990 8.153 -10.650 1.00 95.57 C \\\\nATOM 3508 CD PRO A 445 -12.852 6.911 -10.854 1.00 95.57 C \\\\nATOM 3509 N LEU A 446 -12.584 7.146 -14.758 1.00 96.12 N \\\\nATOM 3510 CA LEU A 446 -12.530 6.893 -16.207 1.00 96.12 C \\\\nATOM 3511 C LEU A 446 -13.920 6.832 -16.847 1.00 96.12 C \\\\nATOM 3512 CB LEU A 446 -11.786 5.576 -16.497 1.00 96.12 C \\\\nATOM 3513 O LEU A 446 -14.143 7.458 -17.876 1.00 96.12 O \\\\nATOM 3514 CG LEU A 446 -10.261 5.663 -16.366 1.00 96.12 C \\\\nATOM 3515 CD1 LEU A 446 -9.644 4.269 -16.456 1.00 96.12 C \\\\nATOM 3516 CD2 LEU A 446 -9.629 6.538 -17.453 1.00 96.12 C \\\\nATOM 3517 N GLN A 447 -14.867 6.114 -16.239 1.00 93.99 N \\\\nATOM 3518 CA GLN A 447 -16.236 6.022 -16.746 1.00 93.99 C \\\\nATOM 3519 C GLN A 447 -16.928 7.388 -16.734 1.00 93.99 C \\\\nATOM 3520 CB GLN A 447 -17.025 5.007 -15.900 1.00 93.99 C \\\\nATOM 3521 O GLN A 447 -17.694 7.710 -17.641 1.00 93.99 O \\\\nATOM 3522 CG GLN A 447 -18.453 4.827 -16.434 1.00 93.99 C \\\\nATOM 3523 CD GLN A 447 -19.274 3.840 -15.619 1.00 93.99 C \\\\nATOM 3524 NE2 GLN A 447 -19.847 2.835 -16.240 1.00 93.99 N \\\\nATOM 3525 OE1 GLN A 447 -19.488 3.984 -14.428 1.00 93.99 O \\\\nATOM 3526 N TRP A 448 -16.685 8.201 -15.705 1.00 93.61 N \\\\nATOM 3527 CA TRP A 448 -17.250 9.544 -15.649 1.00 93.61 C \\\\nATOM 3528 C TRP A 448 -16.668 10.445 -16.736 1.00 93.61 C \\\\nATOM 3529 CB TRP A 448 -17.020 10.139 -14.266 1.00 93.61 C \\\\nATOM 3530 O TRP A 448 -17.416 11.158 -17.403 1.00 93.61 O \\\\nATOM 3531 CG TRP A 448 -17.873 11.319 -13.917 1.00 93.61 C \\\\nATOM 3532 CD1 TRP A 448 -18.899 11.839 -14.637 1.00 93.61 C \\\\nATOM 3533 CD2 TRP A 448 -17.793 12.127 -12.714 1.00 93.61 C \\\\nATOM 3534 CE2 TRP A 448 -18.872 13.057 -12.721 1.00 93.61 C \\\\nATOM 3535 CE3 TRP A 448 -16.926 12.138 -11.604 1.00 93.61 C \\\\nATOM 3536 NE1 TRP A 448 -19.496 12.864 -13.931 1.00 93.61 N \\\\nATOM 3537 CH2 TRP A 448 -18.250 13.892 -10.548 1.00 93.61 C \\\\nATOM 3538 CZ2 TRP A 448 -19.116 13.916 -11.649 1.00 93.61 C \\\\nATOM 3539 CZ3 TRP A 448 -17.154 13.009 -10.530 1.00 93.61 C \\\\nATOM 3540 N LEU A 449 -15.354 10.358 -16.948 1.00 94.28 N \\\\nATOM 3541 CA LEU A 449 -14.655 11.076 -18.003 1.00 94.28 C \\\\nATOM 3542 C LEU A 449 -15.173 10.695 -19.397 1.00 94.28 C \\\\nATOM 3543 CB LEU A 449 -13.153 10.779 -17.862 1.00 94.28 C \\\\nATOM 3544 O LEU A 449 -15.466 11.579 -20.195 1.00 94.28 O \\\\nATOM 3545 CG LEU A 449 -12.289 11.610 -18.815 1.00 94.28 C \\\\nATOM 3546 CD1 LEU A 449 -12.347 13.079 -18.418 1.00 94.28 C \\\\nATOM 3547 CD2 LEU A 449 -10.841 11.143 -18.742 1.00 94.28 C \\\\nATOM 3548 N ASP A 450 -15.347 9.401 -19.664 1.00 92.60 N \\\\nATOM 3549 CA ASP A 450 -15.885 8.874 -20.924 1.00 92.60 C \\\\nATOM 3550 C ASP A 450 -17.291 9.424 -21.227 1.00 92.60 C \\\\nATOM 3551 CB ASP A 450 -15.886 7.343 -20.822 1.00 92.60 C \\\\nATOM 3552 O ASP A 450 -17.558 9.945 -22.313 1.00 92.60 O \\\\nATOM 3553 CG ASP A 450 -16.420 6.688 -22.093 1.00 92.60 C \\\\nATOM 3554 OD1 ASP A 450 -15.698 6.749 -23.110 1.00 92.60 O \\\\nATOM 3555 OD2 ASP A 450 -17.537 6.128 -22.015 1.00 92.60 O \\\\nATOM 3556 N LYS A 451 -18.181 9.440 -20.225 1.00 91.83 N \\\\nATOM 3557 CA LYS A 451 -19.519 10.041 -20.363 1.00 91.83 C \\\\nATOM 3558 C LYS A 451 -19.490 11.549 -20.640 1.00 91.83 C \\\\nATOM 3559 CB LYS A 451 -20.346 9.800 -19.104 1.00 91.83 C \\\\nATOM 3560 O LYS A 451 -20.411 12.062 -21.264 1.00 91.83 O \\\\nATOM 3561 CG LYS A 451 -20.774 8.346 -18.886 1.00 91.83 C \\\\nATOM 3562 CD LYS A 451 -21.546 8.299 -17.564 1.00 91.83 C \\\\nATOM 3563 CE LYS A 451 -21.927 6.876 -17.167 1.00 91.83 C \\\\nATOM 3564 NZ LYS A 451 -22.588 6.894 -15.839 1.00 91.83 N \\\\nATOM 3565 N VAL A 452 -18.482 12.272 -20.151 1.00 91.75 N \\\\nATOM 3566 CA VAL A 452 -18.313 13.704 -20.452 1.00 91.75 C \\\\nATOM 3567 C VAL A 452 -17.764 13.886 -21.868 1.00 91.75 C \\\\nATOM 3568 CB VAL A 452 -17.432 14.393 -19.392 1.00 91.75 C \\\\nATOM 3569 O VAL A 452 -18.312 14.673 -22.635 1.00 91.75 O \\\\nATOM 3570 CG1 VAL A 452 -17.045 15.822 -19.781 1.00 91.75 C \\\\nATOM 3571 CG2 VAL A 452 -18.180 14.477 -18.054 1.00 91.75 C \\\\nATOM 3572 N LEU A 453 -16.729 13.131 -22.246 1.00 91.05 N \\\\nATOM 3573 CA LEU A 453 -16.115 13.199 -23.577 1.00 91.05 C \\\\nATOM 3574 C LEU A 453 -17.106 12.863 -24.695 1.00 91.05 C \\\\nATOM 3575 CB LEU A 453 -14.907 12.248 -23.633 1.00 91.05 C \\\\nATOM 3576 O LEU A 453 -17.135 13.558 -25.707 1.00 91.05 O \\\\nATOM 3577 CG LEU A 453 -13.657 12.782 -22.915 1.00 91.05 C \\\\nATOM 3578 CD1 LEU A 453 -12.607 11.677 -22.819 1.00 91.05 C \\\\nATOM 3579 CD2 LEU A 453 -13.034 13.964 -23.666 1.00 91.05 C \\\\nATOM 3580 N THR A 454 -17.974 11.870 -24.489 1.00 88.74 N \\\\nATOM 3581 CA THR A 454 -19.038 11.510 -25.446 1.00 88.74 C \\\\nATOM 3582 C THR A 454 -20.045 12.639 -25.704 1.00 88.74 C \\\\nATOM 3583 CB THR A 454 -19.797 10.249 -25.000 1.00 88.74 C \\\\nATOM 3584 O THR A 454 -20.705 12.629 -26.739 1.00 88.74 O \\\\nATOM 3585 CG2 THR A 454 -18.964 8.980 -25.160 1.00 88.74 C \\\\nATOM 3586 OG1 THR A 454 -20.152 10.317 -23.644 1.00 88.74 O \\\\nATOM 3587 N GLN A 455 -20.145 13.631 -24.811 1.00 86.80 N \\\\nATOM 3588 CA GLN A 455 -21.014 14.806 -24.960 1.00 86.80 C \\\\nATOM 3589 C GLN A 455 -20.277 16.044 -25.514 1.00 86.80 C \\\\nATOM 3590 CB GLN A 455 -21.657 15.128 -23.598 1.00 86.80 C \\\\nATOM 3591 O GLN A 455 -20.926 16.977 -25.978 1.00 86.80 O \\\\nATOM 3592 CG GLN A 455 -22.542 14.008 -23.028 1.00 86.80 C \\\\nATOM 3593 CD GLN A 455 -23.867 13.803 -23.755 1.00 86.80 C \\\\nATOM 3594 NE2 GLN A 455 -24.498 12.666 -23.561 1.00 86.80 N \\\\nATOM 3595 OE1 GLN A 455 -24.396 14.643 -24.464 1.00 86.80 O \\\\nATOM 3596 N MET A 456 -18.937 16.067 -25.489 1.00 83.78 N \\\\nATOM 3597 CA MET A 456 -18.105 17.230 -25.855 1.00 83.78 C \\\\nATOM 3598 C MET A 456 -17.816 17.361 -27.364 1.00 83.78 C \\\\nATOM 3599 CB MET A 456 -16.786 17.177 -25.059 1.00 83.78 C \\\\nATOM 3600 O MET A 456 -17.165 18.316 -27.781 1.00 83.78 O \\\\nATOM 3601 CG MET A 456 -16.946 17.591 -23.591 1.00 83.78 C \\\\nATOM 3602 SD MET A 456 -17.155 19.371 -23.298 1.00 83.78 S \\\\nATOM 3603 CE MET A 456 -15.520 20.010 -23.739 1.00 83.78 C \\\\nATOM 3604 N GLY A 457 -18.270 16.423 -28.200 1.00 82.72 N \\\\nATOM 3605 CA GLY A 457 -17.965 16.416 -29.636 1.00 82.72 C \\\\nATOM 3606 C GLY A 457 -16.554 15.898 -29.944 1.00 82.72 C \\\\nATOM 3607 O GLY A 457 -16.102 14.932 -29.336 1.00 82.72 O \\\\nATOM 3608 N SER A 458 -15.869 16.502 -30.919 1.00 82.57 N \\\\nATOM 3609 CA SER A 458 -14.536 16.088 -31.390 1.00 82.57 C \\\\nATOM 3610 C SER A 458 -13.502 17.216 -31.256 1.00 82.57 C \\\\nATOM 3611 CB SER A 458 -14.626 15.612 -32.849 1.00 82.57 C \\\\nATOM 3612 O SER A 458 -13.892 18.384 -31.189 1.00 82.57 O \\\\nATOM 3613 OG SER A 458 -14.997 16.664 -33.725 1.00 82.57 O \\\\nATOM 3614 N PRO A 459 -12.187 16.917 -31.300 1.00 83.95 N \\\\nATOM 3615 CA PRO A 459 -11.150 17.944 -31.404 1.00 83.95 C \\\\nATOM 3616 C PRO A 459 -11.398 18.912 -32.571 1.00 83.95 C \\\\nATOM 3617 CB PRO A 459 -9.830 17.189 -31.592 1.00 83.95 C \\\\nATOM 3618 O PRO A 459 -11.916 18.519 -33.619 1.00 83.95 O \\\\nATOM 3619 CG PRO A 459 -10.104 15.818 -30.980 1.00 83.95 C \\\\nATOM 3620 CD PRO A 459 -11.586 15.591 -31.267 1.00 83.95 C \\\\nATOM 3621 N SER A 460 -10.991 20.174 -32.407 1.00 82.81 N \\\\nATOM 3622 CA SER A 460 -11.108 21.203 -33.452 1.00 82.81 C \\\\nATOM 3623 C SER A 460 -10.191 20.929 -34.648 1.00 82.81 C \\\\nATOM 3624 CB SER A 460 -10.787 22.579 -32.856 1.00 82.81 C \\\\nATOM 3625 O SER A 460 -10.555 21.194 -35.795 1.00 82.81 O \\\\nATOM 3626 OG SER A 460 -9.520 22.558 -32.219 1.00 82.81 O \\\\nATOM 3627 N VAL A 461 -9.008 20.365 -34.391 1.00 84.86 N \\\\nATOM 3628 CA VAL A 461 -8.042 19.977 -35.421 1.00 84.86 C \\\\nATOM 3629 C VAL A 461 -8.386 18.581 -35.931 1.00 84.86 C \\\\nATOM 3630 CB VAL A 461 -6.596 20.052 -34.897 1.00 84.86 C \\\\nATOM 3631 O VAL A 461 -8.351 17.603 -35.184 1.00 84.86 O \\\\nATOM 3632 CG1 VAL A 461 -5.591 19.735 -36.012 1.00 84.86 C \\\\nATOM 3633 CG2 VAL A 461 -6.274 21.456 -34.364 1.00 84.86 C \\\\nATOM 3634 N ARG A 462 -8.705 18.476 -37.224 1.00 86.91 N \\\\nATOM 3635 CA ARG A 462 -8.912 17.178 -37.878 1.00 86.91 C \\\\nATOM 3636 C ARG A 462 -7.580 16.446 -38.015 1.00 86.91 C \\\\nATOM 3637 CB ARG A 462 -9.587 17.337 -39.247 1.00 86.91 C \\\\nATOM 3638 O ARG A 462 -6.581 17.039 -38.412 1.00 86.91 O \\\\nATOM 3639 CG ARG A 462 -11.013 17.890 -39.126 1.00 86.91 C \\\\nATOM 3640 CD ARG A 462 -11.684 17.905 -40.502 1.00 86.91 C \\\\nATOM 3641 NE ARG A 462 -13.033 18.495 -40.434 1.00 86.91 N \\\\nATOM 3642 NH1 ARG A 462 -13.544 18.318 -42.665 1.00 86.91 N \\\\nATOM 3643 NH2 ARG A 462 -15.020 19.234 -41.262 1.00 86.91 N \\\\nATOM 3644 CZ ARG A 462 -13.857 18.679 -41.451 1.00 86.91 C \\\\nATOM 3645 N CYS A 463 -7.589 15.148 -37.736 1.00 86.96 N \\\\nATOM 3646 CA CYS A 463 -6.437 14.287 -37.969 1.00 86.96 C \\\\nATOM 3647 C CYS A 463 -6.320 13.944 -39.464 1.00 86.96 C \\\\nATOM 3648 CB CYS A 463 -6.570 13.047 -37.079 1.00 86.96 C \\\\nATOM 3649 O CYS A 463 -7.328 13.671 -40.121 1.00 86.96 O \\\\nATOM 3650 SG CYS A 463 -4.996 12.153 -37.080 1.00 86.96 S \\\\nATOM 3651 N SER A 464 -5.099 13.967 -40.000 1.00 88.07 N \\\\nATOM 3652 CA SER A 464 -4.820 13.510 -41.363 1.00 88.07 C \\\\nATOM 3653 C SER A 464 -4.835 11.983 -41.414 1.00 88.07 C \\\\nATOM 3654 CB SER A 464 -3.461 14.040 -41.824 1.00 88.07 C \\\\nATOM 3655 O SER A 464 -4.310 11.321 -40.526 1.00 88.07 O \\\\nATOM 3656 OG SER A 464 -3.099 13.502 -43.084 1.00 88.07 O \\\\nATOM 3657 N SER A 465 -5.379 11.407 -42.485 1.00 91.00 N \\\\nATOM 3658 CA SER A 465 -5.290 9.965 -42.748 1.00 91.00 C \\\\nATOM 3659 C SER A 465 -3.976 9.551 -43.433 1.00 91.00 C \\\\nATOM 3660 CB SER A 465 -6.508 9.521 -43.561 1.00 91.00 C \\\\nATOM 3661 O SER A 465 -3.864 8.409 -43.870 1.00 91.00 O \\\\nATOM 3662 OG SER A 465 -6.528 10.173 -44.818 1.00 91.00 O \\\\nATOM 3663 N MET A 466 -3.021 10.477 -43.604 1.00 85.74 N \\\\nATOM 3664 CA MET A 466 -1.770 10.264 -44.353 1.00 85.74 C \\\\nATOM 3665 C MET A 466 -0.494 10.702 -43.614 1.00 85.74 C \\\\nATOM 3666 CB MET A 466 -1.822 11.027 -45.692 1.00 85.74 C \\\\nATOM 3667 O MET A 466 0.590 10.472 -44.144 1.00 85.74 O \\\\nATOM 3668 CG MET A 466 -2.996 10.644 -46.597 1.00 85.74 C \\\\nATOM 3669 SD MET A 466 -2.952 11.423 -48.240 1.00 85.74 S \\\\nATOM 3670 CE MET A 466 -1.732 10.371 -49.073 1.00 85.74 C \\\\nATOM 3671 N SER A 467 -0.609 11.397 -42.475 1.00 72.38 N \\\\nATOM 3672 CA SER A 467 0.539 11.969 -41.746 1.00 72.38 C \\\\nATOM 3673 C SER A 467 1.298 10.949 -40.918 1.00 72.38 C \\\\nATOM 3674 CB SER A 467 0.108 13.100 -40.821 1.00 72.38 C \\\\nATOM 3675 O SER A 467 0.599 10.142 -40.264 1.00 72.38 O \\\\nATOM 3676 OG SER A 467 -0.858 12.568 -39.944 1.00 72.38 O \\\\nATOM 3677 OXT SER A 467 2.532 11.126 -40.865 1.00 72.38 O \\\\nTER 3678 SER A 467 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 9, 'score': 0}, {'residue_no': 10, 'score': 0}, {'residue_no': 11, 'score': 0}, {'residue_no': 12, 'score': 0}, {'residue_no': 13, 'score': 0}, {'residue_no': 14, 'score': 0}, {'residue_no': 15, 'score': 0}, {'residue_no': 16, 'score': 0}, {'residue_no': 17, 'score': 0}, {'residue_no': 18, 'score': 0}, {'residue_no': 19, 'score': 0}, {'residue_no': 20, 'score': 0}, {'residue_no': 21, 'score': 0}, {'residue_no': 22, 'score': 0}, {'residue_no': 23, 'score': 0}, {'residue_no': 24, 'score': 0}, {'residue_no': 25, 'score': 0}, {'residue_no': 26, 'score': 0}, {'residue_no': 27, 'score': 0}, {'residue_no': 28, 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ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 425 UNP P84022 SMAD3_HUMAN 1 425 \\\\nSEQRES 1 A 425 MET SER SER ILE LEU PRO PHE THR PRO PRO ILE VAL LYS \\\\nSEQRES 2 A 425 ARG LEU LEU GLY TRP LYS LYS GLY GLU GLN ASN GLY GLN \\\\nSEQRES 3 A 425 GLU GLU LYS TRP CYS GLU LYS ALA VAL LYS SER LEU VAL \\\\nSEQRES 4 A 425 LYS LYS LEU LYS LYS THR GLY GLN LEU ASP GLU LEU GLU \\\\nSEQRES 5 A 425 LYS ALA ILE THR THR GLN ASN VAL ASN THR LYS CYS ILE \\\\nSEQRES 6 A 425 THR ILE PRO ARG SER LEU ASP GLY ARG LEU GLN VAL SER \\\\nSEQRES 7 A 425 HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG LEU \\\\nSEQRES 8 A 425 TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU ARG \\\\nSEQRES 9 A 425 ALA MET GLU LEU CYS GLU PHE ALA PHE ASN MET LYS LYS \\\\nSEQRES 10 A 425 ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG VAL \\\\nSEQRES 11 A 425 GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG HIS \\\\nSEQRES 12 A 425 THR GLU ILE PRO ALA GLU PHE PRO PRO LEU ASP ASP TYR \\\\nSEQRES 13 A 425 SER HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA GLY \\\\nSEQRES 14 A 425 ILE GLU PRO GLN SER ASN ILE PRO GLU THR PRO PRO PRO \\\\nSEQRES 15 A 425 GLY TYR LEU SER GLU ASP GLY GLU THR SER ASP HIS GLN \\\\nSEQRES 16 A 425 MET ASN HIS SER MET ASP ALA GLY SER PRO ASN LEU SER \\\\nSEQRES 17 A 425 PRO ASN PRO MET SER PRO ALA HIS ASN ASN LEU ASP LEU \\\\nSEQRES 18 A 425 GLN PRO VAL THR TYR CYS GLU PRO ALA PHE TRP CYS SER \\\\nSEQRES 19 A 425 ILE SER TYR TYR GLU LEU ASN GLN ARG VAL GLY GLU THR \\\\nSEQRES 20 A 425 PHE HIS ALA SER GLN PRO SER MET THR VAL ASP GLY PHE \\\\nSEQRES 21 A 425 THR ASP PRO SER ASN SER GLU ARG PHE CYS LEU GLY LEU \\\\nSEQRES 22 A 425 LEU SER ASN VAL ASN ARG ASN ALA ALA VAL GLU LEU THR \\\\nSEQRES 23 A 425 ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU TYR TYR ILE \\\\nSEQRES 24 A 425 GLY GLY GLU VAL PHE ALA GLU CYS LEU SER ASP SER ALA \\\\nSEQRES 25 A 425 ILE PHE VAL GLN SER PRO ASN CYS ASN GLN ARG TYR GLY \\\\nSEQRES 26 A 425 TRP HIS PRO ALA THR VAL CYS LYS ILE PRO PRO GLY CYS \\\\nSEQRES 27 A 425 ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE ALA ALA LEU \\\\nSEQRES 28 A 425 LEU ALA GLN SER VAL ASN GLN GLY PHE GLU ALA VAL TYR \\\\nSEQRES 29 A 425 GLN LEU THR ARG MET CYS THR ILE ARG MET SER PHE VAL \\\\nSEQRES 30 A 425 LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN THR VAL THR \\\\nSEQRES 31 A 425 SER THR PRO CYS TRP ILE GLU LEU HIS LEU ASN GLY PRO \\\\nSEQRES 32 A 425 LEU GLN TRP LEU ASP LYS VAL LEU THR GLN MET GLY SER \\\\nSEQRES 33 A 425 PRO SER ILE ARG CYS SER SER VAL SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 4.273 0.848 52.113 1.00 39.24 N \\\\nATOM 2 CA MET A 1 3.232 1.902 52.065 1.00 39.24 C \\\\nATOM 3 C MET A 1 2.383 1.673 50.826 1.00 39.24 C \\\\nATOM 4 CB MET A 1 3.847 3.308 52.057 1.00 39.24 C \\\\nATOM 5 O MET A 1 2.942 1.318 49.796 1.00 39.24 O \\\\nATOM 6 CG MET A 1 4.474 3.642 53.416 1.00 39.24 C \\\\nATOM 7 SD MET A 1 5.360 5.216 53.426 1.00 39.24 S \\\\nATOM 8 CE MET A 1 5.935 5.252 55.146 1.00 39.24 C \\\\nATOM 9 N SER A 2 1.062 1.771 50.948 1.00 36.12 N \\\\nATOM 10 CA SER A 2 0.109 1.246 49.960 1.00 36.12 C \\\\nATOM 11 C SER A 2 0.079 2.048 48.655 1.00 36.12 C \\\\nATOM 12 CB SER A 2 -1.295 1.213 50.580 1.00 36.12 C \\\\nATOM 13 O SER A 2 -0.137 3.258 48.672 1.00 36.12 O \\\\nATOM 14 OG SER A 2 -1.227 0.650 51.880 1.00 36.12 O \\\\nATOM 15 N SER A 3 0.231 1.370 47.514 1.00 38.89 N \\\\nATOM 16 CA SER A 3 0.023 1.960 46.189 1.00 38.89 C \\\\nATOM 17 C SER A 3 -1.462 2.235 45.957 1.00 38.89 C \\\\nATOM 18 CB SER A 3 0.557 1.029 45.093 1.00 38.89 C \\\\nATOM 19 O SER A 3 -2.252 1.303 45.792 1.00 38.89 O \\\\nATOM 20 OG SER A 3 -0.053 -0.245 45.163 1.00 38.89 O \\\\nATOM 21 N ILE A 4 -1.855 3.506 45.916 1.00 47.07 N \\\\nATOM 22 CA ILE A 4 -3.232 3.888 45.596 1.00 47.07 C \\\\nATOM 23 C ILE A 4 -3.496 3.548 44.123 1.00 47.07 C \\\\nATOM 24 CB ILE A 4 -3.468 5.379 45.927 1.00 47.07 C \\\\nATOM 25 O ILE A 4 -2.938 4.179 43.224 1.00 47.07 O \\\\nATOM 26 CG1 ILE A 4 -3.261 5.625 47.443 1.00 47.07 C \\\\nATOM 27 CG2 ILE A 4 -4.879 5.821 45.493 1.00 47.07 C \\\\nATOM 28 CD1 ILE A 4 -3.274 7.105 47.845 1.00 47.07 C \\\\nATOM 29 N LEU A 5 -4.344 2.546 43.868 1.00 53.20 N \\\\nATOM 30 CA LEU A 5 -4.810 2.232 42.516 1.00 53.20 C \\\\nATOM 31 C LEU A 5 -5.549 3.457 41.941 1.00 53.20 C \\\\nATOM 32 CB LEU A 5 -5.721 0.989 42.534 1.00 53.20 C \\\\nATOM 33 O LEU A 5 -6.408 4.021 42.625 1.00 53.20 O \\\\nATOM 34 CG LEU A 5 -4.992 -0.340 42.812 1.00 53.20 C \\\\nATOM 35 CD1 LEU A 5 -6.017 -1.450 43.037 1.00 53.20 C \\\\nATOM 36 CD2 LEU A 5 -4.094 -0.756 41.643 1.00 53.20 C \\\\nATOM 37 N PRO A 6 -5.246 3.897 40.705 1.00 60.37 N \\\\nATOM 38 CA PRO A 6 -5.812 5.125 40.159 1.00 60.37 C \\\\nATOM 39 C PRO A 6 -7.330 4.999 39.986 1.00 60.37 C \\\\nATOM 40 CB PRO A 6 -5.074 5.367 38.837 1.00 60.37 C \\\\nATOM 41 O PRO A 6 -7.816 4.186 39.200 1.00 60.37 O \\\\nATOM 42 CG PRO A 6 -4.604 3.971 38.422 1.00 60.37 C \\\\nATOM 43 CD PRO A 6 -4.319 3.294 39.760 1.00 60.37 C \\\\nATOM 44 N PHE A 7 -8.088 5.832 40.702 1.00 70.62 N \\\\nATOM 45 CA PHE A 7 -9.549 5.804 40.675 1.00 70.62 C \\\\nATOM 46 C PHE A 7 -10.094 6.178 39.288 1.00 70.62 C \\\\nATOM 47 CB PHE A 7 -10.103 6.723 41.773 1.00 70.62 C \\\\nATOM 48 O PHE A 7 -10.023 7.331 38.853 1.00 70.62 O \\\\nATOM 49 CG PHE A 7 -11.618 6.706 41.884 1.00 70.62 C \\\\nATOM 50 CD1 PHE A 7 -12.391 7.683 41.227 1.00 70.62 C \\\\nATOM 51 CD2 PHE A 7 -12.256 5.721 42.662 1.00 70.62 C \\\\nATOM 52 CE1 PHE A 7 -13.792 7.682 41.356 1.00 70.62 C \\\\nATOM 53 CE2 PHE A 7 -13.657 5.718 42.788 1.00 70.62 C \\\\nATOM 54 CZ PHE A 7 -14.425 6.699 42.137 1.00 70.62 C \\\\nATOM 55 N THR A 8 -10.670 5.201 38.590 1.00 75.98 N \\\\nATOM 56 CA THR A 8 -11.340 5.419 37.302 1.00 75.98 C \\\\nATOM 57 C THR A 8 -12.798 5.827 37.530 1.00 75.98 C \\\\nATOM 58 CB THR A 8 -11.204 4.193 36.395 1.00 75.98 C \\\\nATOM 59 O THR A 8 -13.551 5.029 38.095 1.00 75.98 O \\\\nATOM 60 CG2 THR A 8 -11.939 4.349 35.065 1.00 75.98 C \\\\nATOM 61 OG1 THR A 8 -9.832 4.107 36.111 1.00 75.98 O \\\\nATOM 62 N PRO A 9 -13.225 7.032 37.086 1.00 83.88 N \\\\nATOM 63 CA PRO A 9 -14.572 7.540 37.343 1.00 83.88 C \\\\nATOM 64 C PRO A 9 -15.673 6.578 36.863 1.00 83.88 C \\\\nATOM 65 CB PRO A 9 -14.661 8.884 36.610 1.00 83.88 C \\\\nATOM 66 O PRO A 9 -15.524 6.006 35.780 1.00 83.88 O \\\\nATOM 67 CG PRO A 9 -13.212 9.362 36.576 1.00 83.88 C \\\\nATOM 68 CD PRO A 9 -12.428 8.062 36.428 1.00 83.88 C \\\\nATOM 69 N PRO A 10 -16.809 6.445 37.578 1.00 90.89 N \\\\nATOM 70 CA PRO A 10 -17.865 5.488 37.225 1.00 90.89 C \\\\nATOM 71 C PRO A 10 -18.361 5.599 35.776 1.00 90.89 C \\\\nATOM 72 CB PRO A 10 -18.993 5.742 38.231 1.00 90.89 C \\\\nATOM 73 O PRO A 10 -18.535 4.588 35.102 1.00 90.89 O \\\\nATOM 74 CG PRO A 10 -18.247 6.237 39.468 1.00 90.89 C \\\\nATOM 75 CD PRO A 10 -17.097 7.049 38.875 1.00 90.89 C \\\\nATOM 76 N ILE A 11 -18.503 6.820 35.248 1.00 92.27 N \\\\nATOM 77 CA ILE A 11 -18.903 7.038 33.849 1.00 92.27 C \\\\nATOM 78 C ILE A 11 -17.867 6.545 32.827 1.00 92.27 C \\\\nATOM 79 CB ILE A 11 -19.300 8.510 33.624 1.00 92.27 C \\\\nATOM 80 O ILE A 11 -18.248 6.053 31.772 1.00 92.27 O \\\\nATOM 81 CG1 ILE A 11 -19.974 8.665 32.243 1.00 92.27 C \\\\nATOM 82 CG2 ILE A 11 -18.109 9.479 33.789 1.00 92.27 C \\\\nATOM 83 CD1 ILE A 11 -20.932 9.855 32.186 1.00 92.27 C \\\\nATOM 84 N VAL A 12 -16.570 6.592 33.149 1.00 93.66 N \\\\nATOM 85 CA VAL A 12 -15.523 6.020 32.287 1.00 93.66 C \\\\nATOM 86 C VAL A 12 -15.661 4.498 32.246 1.00 93.66 C \\\\nATOM 87 CB VAL A 12 -14.116 6.446 32.749 1.00 93.66 C \\\\nATOM 88 O VAL A 12 -15.583 3.927 31.165 1.00 93.66 O \\\\nATOM 89 CG1 VAL A 12 -12.997 5.748 31.970 1.00 93.66 C \\\\nATOM 90 CG2 VAL A 12 -13.919 7.961 32.599 1.00 93.66 C \\\\nATOM 91 N LYS A 13 -15.937 3.848 33.388 1.00 92.88 N \\\\nATOM 92 CA LYS A 13 -16.201 2.399 33.430 1.00 92.88 C \\\\nATOM 93 C LYS A 13 -17.434 2.024 32.600 1.00 92.88 C \\\\nATOM 94 CB LYS A 13 -16.346 1.887 34.873 1.00 92.88 C \\\\nATOM 95 O LYS A 13 -17.344 1.111 31.788 1.00 92.88 O \\\\nATOM 96 CG LYS A 13 -15.076 2.061 35.721 1.00 92.88 C \\\\nATOM 97 CD LYS A 13 -15.226 1.310 37.053 1.00 92.88 C \\\\nATOM 98 CE LYS A 13 -13.955 1.424 37.902 1.00 92.88 C \\\\nATOM 99 NZ LYS A 13 -14.041 0.572 39.118 1.00 92.88 N \\\\nATOM 100 N ARG A 14 -18.548 2.762 32.738 1.00 93.78 N \\\\nATOM 101 CA ARG A 14 -19.767 2.548 31.930 1.00 93.78 C \\\\nATOM 102 C ARG A 14 -19.486 2.672 30.430 1.00 93.78 C \\\\nATOM 103 CB ARG A 14 -20.903 3.501 32.350 1.00 93.78 C \\\\nATOM 104 O ARG A 14 -19.812 1.762 29.681 1.00 93.78 O \\\\nATOM 105 CG ARG A 14 -21.494 3.160 33.730 1.00 93.78 C \\\\nATOM 106 CD ARG A 14 -22.747 3.992 34.049 1.00 93.78 C \\\\nATOM 107 NE ARG A 14 -22.461 5.438 34.153 1.00 93.78 N \\\\nATOM 108 NH1 ARG A 14 -24.649 6.160 34.141 1.00 93.78 N \\\\nATOM 109 NH2 ARG A 14 -23.035 7.644 34.071 1.00 93.78 N \\\\nATOM 110 CZ ARG A 14 -23.376 6.396 34.150 1.00 93.78 C \\\\nATOM 111 N LEU A 15 -18.822 3.747 29.998 1.00 95.91 N \\\\nATOM 112 CA LEU A 15 -18.482 3.969 28.586 1.00 95.91 C \\\\nATOM 113 C LEU A 15 -17.500 2.923 28.024 1.00 95.91 C \\\\nATOM 114 CB LEU A 15 -17.910 5.388 28.430 1.00 95.91 C \\\\nATOM 115 O LEU A 15 -17.610 2.564 26.853 1.00 95.91 O \\\\nATOM 116 CG LEU A 15 -18.943 6.527 28.539 1.00 95.91 C \\\\nATOM 117 CD1 LEU A 15 -18.201 7.866 28.557 1.00 95.91 C \\\\nATOM 118 CD2 LEU A 15 -19.925 6.546 27.366 1.00 95.91 C \\\\nATOM 119 N LEU A 16 -16.567 2.412 28.835 1.00 94.13 N \\\\nATOM 120 CA LEU A 16 -15.676 1.311 28.444 1.00 94.13 C \\\\nATOM 121 C LEU A 16 -16.401 -0.038 28.358 1.00 94.13 C \\\\nATOM 122 CB LEU A 16 -14.492 1.222 29.420 1.00 94.13 C \\\\nATOM 123 O LEU A 16 -16.011 -0.863 27.540 1.00 94.13 O \\\\nATOM 124 CG LEU A 16 -13.472 2.357 29.249 1.00 94.13 C \\\\nATOM 125 CD1 LEU A 16 -12.531 2.383 30.449 1.00 94.13 C \\\\nATOM 126 CD2 LEU A 16 -12.618 2.203 27.986 1.00 94.13 C \\\\nATOM 127 N GLY A 17 -17.481 -0.245 29.117 1.00 93.26 N \\\\nATOM 128 CA GLY A 17 -18.336 -1.435 29.003 1.00 93.26 C \\\\nATOM 129 C GLY A 17 -19.018 -1.590 27.636 1.00 93.26 C \\\\nATOM 130 O GLY A 17 -19.403 -2.694 27.270 1.00 93.26 O \\\\nATOM 131 N TRP A 18 -19.112 -0.509 26.853 1.00 94.37 N \\\\nATOM 132 CA TRP A 18 -19.606 -0.526 25.470 1.00 94.37 C \\\\nATOM 133 C TRP A 18 -18.494 -0.673 24.414 1.00 94.37 C \\\\nATOM 134 CB TRP A 18 -20.455 0.728 25.232 1.00 94.37 C \\\\nATOM 135 O TRP A 18 -18.788 -0.656 23.216 1.00 94.37 O \\\\nATOM 136 CG TRP A 18 -21.736 0.776 26.007 1.00 94.37 C \\\\nATOM 137 CD1 TRP A 18 -21.931 1.414 27.182 1.00 94.37 C \\\\nATOM 138 CD2 TRP A 18 -23.021 0.170 25.667 1.00 94.37 C \\\\nATOM 139 CE2 TRP A 18 -23.955 0.477 26.701 1.00 94.37 C \\\\nATOM 140 CE3 TRP A 18 -23.489 -0.612 24.590 1.00 94.37 C \\\\nATOM 141 NE1 TRP A 18 -23.237 1.240 27.597 1.00 94.37 N \\\\nATOM 142 CH2 TRP A 18 -25.718 -0.746 25.586 1.00 94.37 C \\\\nATOM 143 CZ2 TRP A 18 -25.283 0.029 26.674 1.00 94.37 C \\\\nATOM 144 CZ3 TRP A 18 -24.821 -1.071 24.553 1.00 94.37 C \\\\nATOM 145 N LYS A 19 -17.220 -0.789 24.822 1.00 93.60 N \\\\nATOM 146 CA LYS A 19 -16.084 -0.967 23.904 1.00 93.60 C \\\\nATOM 147 C LYS A 19 -16.252 -2.261 23.100 1.00 93.60 C \\\\nATOM 148 CB LYS A 19 -14.760 -0.988 24.693 1.00 93.60 C \\\\nATOM 149 O LYS A 19 -16.579 -3.304 23.660 1.00 93.60 O \\\\nATOM 150 CG LYS A 19 -13.503 -0.930 23.802 1.00 93.60 C \\\\nATOM 151 CD LYS A 19 -12.226 -1.437 24.497 1.00 93.60 C \\\\nATOM 152 CE LYS A 19 -12.183 -2.968 24.676 1.00 93.60 C \\\\nATOM 153 NZ LYS A 19 -11.800 -3.697 23.436 1.00 93.60 N \\\\nATOM 154 N LYS A 20 -15.966 -2.216 21.800 1.00 91.32 N \\\\nATOM 155 CA LYS A 20 -15.914 -3.401 20.929 1.00 91.32 C \\\\nATOM 156 C LYS A 20 -14.490 -3.979 20.863 1.00 91.32 C \\\\nATOM 157 CB LYS A 20 -16.505 -3.040 19.552 1.00 91.32 C \\\\nATOM 158 O LYS A 20 -13.519 -3.312 21.226 1.00 91.32 O \\\\nATOM 159 CG LYS A 20 -17.955 -2.527 19.601 1.00 91.32 C \\\\nATOM 160 CD LYS A 20 -18.979 -3.550 20.111 1.00 91.32 C \\\\nATOM 161 CE LYS A 20 -20.374 -2.919 20.037 1.00 91.32 C \\\\nATOM 162 NZ LYS A 20 -21.437 -3.873 20.436 1.00 91.32 N \\\\nATOM 163 N GLY A 21 -14.358 -5.219 20.397 1.00 81.67 N \\\\nATOM 164 CA GLY A 21 -13.065 -5.891 20.200 1.00 81.67 C \\\\nATOM 165 C GLY A 21 -12.430 -6.446 21.479 1.00 81.67 C \\\\nATOM 166 O GLY A 21 -12.852 -6.136 22.595 1.00 81.67 O \\\\nATOM 167 N GLU A 22 -11.402 -7.268 21.296 1.00 73.16 N \\\\nATOM 168 CA GLU A 22 -10.807 -8.129 22.325 1.00 73.16 C \\\\nATOM 169 C GLU A 22 -10.076 -7.372 23.455 1.00 73.16 C \\\\nATOM 170 CB GLU A 22 -9.896 -9.162 21.638 1.00 73.16 C \\\\nATOM 171 O GLU A 22 -9.916 -6.143 23.435 1.00 73.16 O \\\\nATOM 172 CG GLU A 22 -10.687 -10.037 20.647 1.00 73.16 C \\\\nATOM 173 CD GLU A 22 -9.842 -11.154 20.025 1.00 73.16 C \\\\nATOM 174 OE1 GLU A 22 -10.462 -12.159 19.619 1.00 73.16 O \\\\nATOM 175 OE2 GLU A 22 -8.606 -10.975 19.959 1.00 73.16 O \\\\nATOM 176 N GLN A 23 -9.677 -8.115 24.493 1.00 63.69 N \\\\nATOM 177 CA GLN A 23 -9.051 -7.596 25.714 1.00 63.69 C \\\\nATOM 178 C GLN A 23 -7.518 -7.703 25.659 1.00 63.69 C \\\\nATOM 179 CB GLN A 23 -9.645 -8.273 26.962 1.00 63.69 C \\\\nATOM 180 O GLN A 23 -6.890 -8.444 26.413 1.00 63.69 O \\\\nATOM 181 CG GLN A 23 -11.129 -7.933 27.172 1.00 63.69 C \\\\nATOM 182 CD GLN A 23 -11.699 -8.529 28.459 1.00 63.69 C \\\\nATOM 183 NE2 GLN A 23 -13.005 -8.607 28.586 1.00 63.69 N \\\\nATOM 184 OE1 GLN A 23 -11.010 -8.940 29.374 1.00 63.69 O \\\\nATOM 185 N ASN A 24 -6.894 -6.916 24.782 1.00 71.71 N \\\\nATOM 186 CA ASN A 24 -5.439 -6.776 24.752 1.00 71.71 C \\\\nATOM 187 C ASN A 24 -4.978 -5.762 25.814 1.00 71.71 C \\\\nATOM 188 CB ASN A 24 -5.008 -6.406 23.321 1.00 71.71 C \\\\nATOM 189 O ASN A 24 -5.207 -4.560 25.680 1.00 71.71 O \\\\nATOM 190 CG ASN A 24 -5.145 -7.581 22.369 1.00 71.71 C \\\\nATOM 191 ND2 ASN A 24 -5.467 -7.332 21.123 1.00 71.71 N \\\\nATOM 192 OD1 ASN A 24 -4.943 -8.719 22.744 1.00 71.71 O \\\\nATOM 193 N GLY A 25 -4.286 -6.210 26.868 1.00 75.50 N \\\\nATOM 194 CA GLY A 25 -4.008 -5.386 28.061 1.00 75.50 C \\\\nATOM 195 C GLY A 25 -3.187 -4.097 27.844 1.00 75.50 C \\\\nATOM 196 O GLY A 25 -3.244 -3.176 28.665 1.00 75.50 O \\\\nATOM 197 N GLN A 26 -2.430 -3.977 26.746 1.00 77.51 N \\\\nATOM 198 CA GLN A 26 -1.778 -2.713 26.361 1.00 77.51 C \\\\nATOM 199 C GLN A 26 -2.749 -1.751 25.656 1.00 77.51 C \\\\nATOM 200 CB GLN A 26 -0.555 -3.004 25.477 1.00 77.51 C \\\\nATOM 201 O GLN A 26 -2.683 -0.536 25.861 1.00 77.51 O \\\\nATOM 202 CG GLN A 26 0.283 -1.736 25.216 1.00 77.51 C \\\\nATOM 203 CD GLN A 26 1.514 -1.993 24.352 1.00 77.51 C \\\\nATOM 204 NE2 GLN A 26 2.425 -1.051 24.240 1.00 77.51 N \\\\nATOM 205 OE1 GLN A 26 1.687 -3.027 23.745 1.00 77.51 O \\\\nATOM 206 N GLU A 27 -3.650 -2.291 24.839 1.00 83.83 N \\\\nATOM 207 CA GLU A 27 -4.675 -1.543 24.116 1.00 83.83 C \\\\nATOM 208 C GLU A 27 -5.765 -1.040 25.064 1.00 83.83 C \\\\nATOM 209 CB GLU A 27 -5.237 -2.448 23.019 1.00 83.83 C \\\\nATOM 210 O GLU A 27 -6.132 0.131 25.007 1.00 83.83 O \\\\nATOM 211 CG GLU A 27 -6.292 -1.739 22.170 1.00 83.83 C \\\\nATOM 212 CD GLU A 27 -6.606 -2.516 20.890 1.00 83.83 C \\\\nATOM 213 OE1 GLU A 27 -6.997 -1.820 19.927 1.00 83.83 O \\\\nATOM 214 OE2 GLU A 27 -6.412 -3.753 20.889 1.00 83.83 O \\\\nATOM 215 N GLU A 28 -6.189 -1.861 26.023 1.00 86.39 N \\\\nATOM 216 CA GLU A 28 -7.170 -1.496 27.046 1.00 86.39 C \\\\nATOM 217 C GLU A 28 -6.731 -0.262 27.858 1.00 86.39 C \\\\nATOM 218 CB GLU A 28 -7.381 -2.720 27.939 1.00 86.39 C \\\\nATOM 219 O GLU A 28 -7.491 0.700 28.008 1.00 86.39 O \\\\nATOM 220 CG GLU A 28 -8.544 -2.503 28.910 1.00 86.39 C \\\\nATOM 221 CD GLU A 28 -8.803 -3.737 29.776 1.00 86.39 C \\\\nATOM 222 OE1 GLU A 28 -9.988 -3.932 30.119 1.00 86.39 O \\\\nATOM 223 OE2 GLU A 28 -7.809 -4.416 30.120 1.00 86.39 O \\\\nATOM 224 N LYS A 29 -5.456 -0.210 28.275 1.00 89.47 N \\\\nATOM 225 CA LYS A 29 -4.847 0.972 28.919 1.00 89.47 C \\\\nATOM 226 C LYS A 29 -4.855 2.214 28.021 1.00 89.47 C \\\\nATOM 227 CB LYS A 29 -3.401 0.651 29.334 1.00 89.47 C \\\\nATOM 228 O LYS A 29 -4.849 3.338 28.529 1.00 89.47 O \\\\nATOM 229 CG LYS A 29 -3.332 -0.299 30.536 1.00 89.47 C \\\\nATOM 230 CD LYS A 29 -1.881 -0.697 30.847 1.00 89.47 C \\\\nATOM 231 CE LYS A 29 -1.878 -1.706 32.000 1.00 89.47 C \\\\nATOM 232 NZ LYS A 29 -0.524 -2.251 32.277 1.00 89.47 N \\\\nATOM 233 N TRP A 30 -4.836 2.050 26.699 1.00 92.08 N \\\\nATOM 234 CA TRP A 30 -4.953 3.163 25.757 1.00 92.08 C \\\\nATOM 235 C TRP A 30 -6.415 3.594 25.561 1.00 92.08 C \\\\nATOM 236 CB TRP A 30 -4.245 2.826 24.440 1.00 92.08 C \\\\nATOM 237 O TRP A 30 -6.694 4.792 25.632 1.00 92.08 O \\\\nATOM 238 CG TRP A 30 -4.246 3.969 23.477 1.00 92.08 C \\\\nATOM 239 CD1 TRP A 30 -3.329 4.961 23.418 1.00 92.08 C \\\\nATOM 240 CD2 TRP A 30 -5.266 4.301 22.489 1.00 92.08 C \\\\nATOM 241 CE2 TRP A 30 -4.898 5.529 21.862 1.00 92.08 C \\\\nATOM 242 CE3 TRP A 30 -6.468 3.691 22.071 1.00 92.08 C \\\\nATOM 243 NE1 TRP A 30 -3.720 5.898 22.481 1.00 92.08 N \\\\nATOM 244 CH2 TRP A 30 -6.859 5.472 20.450 1.00 92.08 C \\\\nATOM 245 CZ2 TRP A 30 -5.674 6.113 20.851 1.00 92.08 C \\\\nATOM 246 CZ3 TRP A 30 -7.259 4.273 21.064 1.00 92.08 C \\\\nATOM 247 N CYS A 31 -7.352 2.652 25.423 1.00 93.06 N \\\\nATOM 248 CA CYS A 31 -8.793 2.918 25.376 1.00 93.06 C \\\\nATOM 249 C CYS A 31 -9.267 3.664 26.631 1.00 93.06 C \\\\nATOM 250 CB CYS A 31 -9.547 1.589 25.225 1.00 93.06 C \\\\nATOM 251 O CYS A 31 -9.973 4.667 26.526 1.00 93.06 O \\\\nATOM 252 SG CYS A 31 -9.173 0.837 23.618 1.00 93.06 S \\\\nATOM 253 N GLU A 32 -8.811 3.253 27.818 1.00 93.85 N \\\\nATOM 254 CA GLU A 32 -9.129 3.942 29.068 1.00 93.85 C \\\\nATOM 255 C GLU A 32 -8.646 5.403 29.051 1.00 93.85 C \\\\nATOM 256 CB GLU A 32 -8.528 3.173 30.256 1.00 93.85 C \\\\nATOM 257 O GLU A 32 -9.396 6.315 29.410 1.00 93.85 O \\\\nATOM 258 CG GLU A 32 -9.135 3.703 31.560 1.00 93.85 C \\\\nATOM 259 CD GLU A 32 -8.376 3.311 32.819 1.00 93.85 C \\\\nATOM 260 OE1 GLU A 32 -9.063 3.201 33.856 1.00 93.85 O \\\\nATOM 261 OE2 GLU A 32 -7.156 3.567 32.892 1.00 93.85 O \\\\nATOM 262 N LYS A 33 -7.422 5.662 28.568 1.00 94.20 N \\\\nATOM 263 CA LYS A 33 -6.902 7.028 28.384 1.00 94.20 C \\\\nATOM 264 C LYS A 33 -7.714 7.822 27.350 1.00 94.20 C \\\\nATOM 265 CB LYS A 33 -5.416 6.983 27.997 1.00 94.20 C \\\\nATOM 266 O LYS A 33 -7.950 9.012 27.570 1.00 94.20 O \\\\nATOM 267 CG LYS A 33 -4.493 6.589 29.163 1.00 94.20 C \\\\nATOM 268 CD LYS A 33 -3.055 6.448 28.644 1.00 94.20 C \\\\nATOM 269 CE LYS A 33 -2.055 6.087 29.746 1.00 94.20 C \\\\nATOM 270 NZ LYS A 33 -0.678 5.970 29.197 1.00 94.20 N \\\\nATOM 271 N ALA A 34 -8.168 7.195 26.262 1.00 95.40 N \\\\nATOM 272 CA ALA A 34 -8.990 7.833 25.229 1.00 95.40 C \\\\nATOM 273 C ALA A 34 -10.354 8.286 25.776 1.00 95.40 C \\\\nATOM 274 CB ALA A 34 -9.158 6.870 24.043 1.00 95.40 C \\\\nATOM 275 O ALA A 34 -10.758 9.432 25.550 1.00 95.40 O \\\\nATOM 276 N VAL A 35 -11.025 7.426 26.551 1.00 96.53 N \\\\nATOM 277 CA VAL A 35 -12.314 7.731 27.196 1.00 96.53 C \\\\nATOM 278 C VAL A 35 -12.135 8.746 28.331 1.00 96.53 C \\\\nATOM 279 CB VAL A 35 -13.021 6.443 27.671 1.00 96.53 C \\\\nATOM 280 O VAL A 35 -12.880 9.723 28.382 1.00 96.53 O \\\\nATOM 281 CG1 VAL A 35 -14.354 6.736 28.371 1.00 96.53 C \\\\nATOM 282 CG2 VAL A 35 -13.342 5.528 26.481 1.00 96.53 C \\\\nATOM 283 N LYS A 36 -11.109 8.614 29.189 1.00 95.17 N \\\\nATOM 284 CA LYS A 36 -10.775 9.626 30.220 1.00 95.17 C \\\\nATOM 285 C LYS A 36 -10.539 11.013 29.600 1.00 95.17 C \\\\nATOM 286 CB LYS A 36 -9.550 9.177 31.053 1.00 95.17 C \\\\nATOM 287 O LYS A 36 -11.017 12.011 30.141 1.00 95.17 O \\\\nATOM 288 CG LYS A 36 -9.892 8.090 32.090 1.00 95.17 C \\\\nATOM 289 CD LYS A 36 -8.669 7.513 32.836 1.00 95.17 C \\\\nATOM 290 CE LYS A 36 -9.134 6.505 33.906 1.00 95.17 C \\\\nATOM 291 NZ LYS A 36 -8.036 5.721 34.536 1.00 95.17 N \\\\nATOM 292 N SER A 37 -9.846 11.077 28.460 1.00 94.09 N \\\\nATOM 293 CA SER A 37 -9.610 12.319 27.710 1.00 94.09 C \\\\nATOM 294 C SER A 37 -10.909 12.918 27.155 1.00 94.09 C \\\\nATOM 295 CB SER A 37 -8.606 12.064 26.581 1.00 94.09 C \\\\nATOM 296 O SER A 37 -11.152 14.114 27.340 1.00 94.09 O \\\\nATOM 297 OG SER A 37 -8.200 13.280 25.982 1.00 94.09 O \\\\nATOM 298 N LEU A 38 -11.783 12.096 26.554 1.00 96.68 N \\\\nATOM 299 CA LEU A 38 -13.076 12.562 26.040 1.00 96.68 C \\\\nATOM 300 C LEU A 38 -13.976 13.088 27.158 1.00 96.68 C \\\\nATOM 301 CB LEU A 38 -13.802 11.447 25.269 1.00 96.68 C \\\\nATOM 302 O LEU A 38 -14.448 14.217 27.080 1.00 96.68 O \\\\nATOM 303 CG LEU A 38 -15.076 11.947 24.555 1.00 96.68 C \\\\nATOM 304 CD1 LEU A 38 -14.806 13.050 23.532 1.00 96.68 C \\\\nATOM 305 CD2 LEU A 38 -15.755 10.790 23.841 1.00 96.68 C \\\\nATOM 306 N VAL A 39 -14.156 12.316 28.232 1.00 96.49 N \\\\nATOM 307 CA VAL A 39 -14.986 12.708 29.382 1.00 96.49 C \\\\nATOM 308 C VAL A 39 -14.498 14.033 29.979 1.00 96.49 C \\\\nATOM 309 CB VAL A 39 -15.018 11.573 30.428 1.00 96.49 C \\\\nATOM 310 O VAL A 39 -15.314 14.888 30.311 1.00 96.49 O \\\\nATOM 311 CG1 VAL A 39 -15.682 11.974 31.753 1.00 96.49 C \\\\nATOM 312 CG2 VAL A 39 -15.792 10.365 29.885 1.00 96.49 C \\\\nATOM 313 N LYS A 40 -13.179 14.271 30.054 1.00 94.22 N \\\\nATOM 314 CA LYS A 40 -12.625 15.559 30.512 1.00 94.22 C \\\\nATOM 315 C LYS A 40 -12.964 16.731 29.576 1.00 94.22 C \\\\nATOM 316 CB LYS A 40 -11.106 15.419 30.726 1.00 94.22 C \\\\nATOM 317 O LYS A 40 -13.098 17.851 30.064 1.00 94.22 O \\\\nATOM 318 CG LYS A 40 -10.491 16.668 31.386 1.00 94.22 C \\\\nATOM 319 CD LYS A 40 -8.990 16.506 31.663 1.00 94.22 C \\\\nATOM 320 CE LYS A 40 -8.447 17.779 32.331 1.00 94.22 C \\\\nATOM 321 NZ LYS A 40 -6.997 17.680 32.651 1.00 94.22 N \\\\nATOM 322 N LYS A 41 -13.090 16.499 28.263 1.00 94.36 N \\\\nATOM 323 CA LYS A 41 -13.530 17.509 27.283 1.00 94.36 C \\\\nATOM 324 C LYS A 41 -15.037 17.759 27.391 1.00 94.36 C \\\\nATOM 325 CB LYS A 41 -13.121 17.098 25.856 1.00 94.36 C \\\\nATOM 326 O LYS A 41 -15.428 18.897 27.622 1.00 94.36 O \\\\nATOM 327 CG LYS A 41 -11.608 17.217 25.604 1.00 94.36 C \\\\nATOM 328 CD LYS A 41 -11.234 16.547 24.272 1.00 94.36 C \\\\nATOM 329 CE LYS A 41 -9.768 16.770 23.874 1.00 94.36 C \\\\nATOM 330 NZ LYS A 41 -9.555 18.101 23.243 1.00 94.36 N \\\\nATOM 331 N LEU A 42 -15.862 16.712 27.337 1.00 96.39 N \\\\nATOM 332 CA LEU A 42 -17.328 16.840 27.334 1.00 96.39 C \\\\nATOM 333 C LEU A 42 -17.905 17.358 28.660 1.00 96.39 C \\\\nATOM 334 CB LEU A 42 -17.979 15.506 26.942 1.00 96.39 C \\\\nATOM 335 O LEU A 42 -18.942 18.012 28.663 1.00 96.39 O \\\\nATOM 336 CG LEU A 42 -17.544 14.942 25.578 1.00 96.39 C \\\\nATOM 337 CD1 LEU A 42 -18.333 13.665 25.325 1.00 96.39 C \\\\nATOM 338 CD2 LEU A 42 -17.753 15.890 24.400 1.00 96.39 C \\\\nATOM 339 N LYS A 43 -17.206 17.166 29.789 1.00 94.30 N \\\\nATOM 340 CA LYS A 43 -17.544 17.844 31.055 1.00 94.30 C \\\\nATOM 341 C LYS A 43 -17.469 19.373 30.981 1.00 94.30 C \\\\nATOM 342 CB LYS A 43 -16.642 17.354 32.200 1.00 94.30 C \\\\nATOM 343 O LYS A 43 -18.084 20.024 31.814 1.00 94.30 O \\\\nATOM 344 CG LYS A 43 -17.148 16.032 32.779 1.00 94.30 C \\\\nATOM 345 CD LYS A 43 -16.408 15.665 34.067 1.00 94.30 C \\\\nATOM 346 CE LYS A 43 -17.047 14.403 34.653 1.00 94.30 C \\\\nATOM 347 NZ LYS A 43 -16.722 14.247 36.092 1.00 94.30 N \\\\nATOM 348 N LYS A 44 -16.711 19.943 30.036 1.00 92.38 N \\\\nATOM 349 CA LYS A 44 -16.640 21.398 29.828 1.00 92.38 C \\\\nATOM 350 C LYS A 44 -17.732 21.922 28.893 1.00 92.38 C \\\\nATOM 351 CB LYS A 44 -15.269 21.811 29.280 1.00 92.38 C \\\\nATOM 352 O LYS A 44 -18.091 23.083 29.018 1.00 92.38 O \\\\nATOM 353 CG LYS A 44 -14.102 21.511 30.230 1.00 92.38 C \\\\nATOM 354 CD LYS A 44 -12.836 22.153 29.652 1.00 92.38 C \\\\nATOM 355 CE LYS A 44 -11.666 22.080 30.633 1.00 92.38 C \\\\nATOM 356 NZ LYS A 44 -10.614 23.058 30.251 1.00 92.38 N \\\\nATOM 357 N THR A 45 -18.227 21.093 27.971 1.00 92.89 N \\\\nATOM 358 CA THR A 45 -19.252 21.469 26.979 1.00 92.89 C \\\\nATOM 359 C THR A 45 -20.670 21.042 27.372 1.00 92.89 C \\\\nATOM 360 CB THR A 45 -18.919 20.901 25.588 1.00 92.89 C \\\\nATOM 361 O THR A 45 -21.625 21.418 26.705 1.00 92.89 O \\\\nATOM 362 CG2 THR A 45 -17.564 21.381 25.065 1.00 92.89 C \\\\nATOM 363 OG1 THR A 45 -18.867 19.493 25.628 1.00 92.89 O \\\\nATOM 364 N GLY A 46 -20.830 20.240 28.431 1.00 94.57 N \\\\nATOM 365 CA GLY A 46 -22.132 19.732 28.886 1.00 94.57 C \\\\nATOM 366 C GLY A 46 -22.679 18.545 28.078 1.00 94.57 C \\\\nATOM 367 O GLY A 46 -23.735 18.020 28.403 1.00 94.57 O \\\\nATOM 368 N GLN A 47 -21.958 18.059 27.064 1.00 96.14 N \\\\nATOM 369 CA GLN A 47 -22.416 16.991 26.154 1.00 96.14 C \\\\nATOM 370 C GLN A 47 -22.206 15.561 26.691 1.00 96.14 C \\\\nATOM 371 CB GLN A 47 -21.702 17.166 24.809 1.00 96.14 C \\\\nATOM 372 O GLN A 47 -22.330 14.589 25.945 1.00 96.14 O \\\\nATOM 373 CG GLN A 47 -22.141 18.419 24.037 1.00 96.14 C \\\\nATOM 374 CD GLN A 47 -21.126 18.755 22.955 1.00 96.14 C \\\\nATOM 375 NE2 GLN A 47 -21.521 18.931 21.715 1.00 96.14 N \\\\nATOM 376 OE1 GLN A 47 -19.939 18.835 23.226 1.00 96.14 O \\\\nATOM 377 N LEU A 48 -21.836 15.397 27.964 1.00 95.75 N \\\\nATOM 378 CA LEU A 48 -21.485 14.086 28.519 1.00 95.75 C \\\\nATOM 379 C LEU A 48 -22.686 13.127 28.579 1.00 95.75 C \\\\nATOM 380 CB LEU A 48 -20.831 14.306 29.891 1.00 95.75 C \\\\nATOM 381 O LEU A 48 -22.535 11.949 28.255 1.00 95.75 O \\\\nATOM 382 CG LEU A 48 -20.337 13.019 30.577 1.00 95.75 C \\\\nATOM 383 CD1 LEU A 48 -19.330 12.230 29.733 1.00 95.75 C \\\\nATOM 384 CD2 LEU A 48 -19.630 13.420 31.875 1.00 95.75 C \\\\nATOM 385 N ASP A 49 -23.866 13.642 28.922 1.00 95.20 N \\\\nATOM 386 CA ASP A 49 -25.095 12.846 29.016 1.00 95.20 C \\\\nATOM 387 C ASP A 49 -25.645 12.495 27.624 1.00 95.20 C \\\\nATOM 388 CB ASP A 49 -26.134 13.605 29.858 1.00 95.20 C \\\\nATOM 389 O ASP A 49 -26.134 11.388 27.407 1.00 95.20 O \\\\nATOM 390 CG ASP A 49 -25.631 13.965 31.265 1.00 95.20 C \\\\nATOM 391 OD1 ASP A 49 -24.765 13.233 31.800 1.00 95.20 O \\\\nATOM 392 OD2 ASP A 49 -26.072 15.015 31.774 1.00 95.20 O \\\\nATOM 393 N GLU A 50 -25.483 13.388 26.638 1.00 95.50 N \\\\nATOM 394 CA GLU A 50 -25.808 13.097 25.234 1.00 95.50 C \\\\nATOM 395 C GLU A 50 -24.863 12.031 24.649 1.00 95.50 C \\\\nATOM 396 CB GLU A 50 -25.787 14.382 24.385 1.00 95.50 C \\\\nATOM 397 O GLU A 50 -25.313 11.192 23.870 1.00 95.50 O \\\\nATOM 398 CG GLU A 50 -26.900 15.395 24.714 1.00 95.50 C \\\\nATOM 399 CD GLU A 50 -28.309 15.049 24.181 1.00 95.50 C \\\\nATOM 400 OE1 GLU A 50 -29.188 15.943 24.269 1.00 95.50 O \\\\nATOM 401 OE2 GLU A 50 -28.551 13.943 23.643 1.00 95.50 O \\\\nATOM 402 N LEU A 51 -23.579 11.987 25.051 1.00 96.84 N \\\\nATOM 403 CA LEU A 51 -22.690 10.876 24.681 1.00 96.84 C \\\\nATOM 404 C LEU A 51 -23.177 9.565 25.306 1.00 96.84 C \\\\nATOM 405 CB LEU A 51 -21.223 11.158 25.072 1.00 96.84 C \\\\nATOM 406 O LEU A 51 -23.258 8.559 24.608 1.00 96.84 O \\\\nATOM 407 CG LEU A 51 -20.286 9.951 24.816 1.00 96.84 C \\\\nATOM 408 CD1 LEU A 51 -20.083 9.664 23.326 1.00 96.84 C \\\\nATOM 409 CD2 LEU A 51 -18.912 10.170 25.444 1.00 96.84 C \\\\nATOM 410 N GLU A 52 -23.492 9.552 26.604 1.00 95.89 N \\\\nATOM 411 CA GLU A 52 -23.990 8.338 27.260 1.00 95.89 C \\\\nATOM 412 C GLU A 52 -25.289 7.842 26.603 1.00 95.89 C \\\\nATOM 413 CB GLU A 52 -24.130 8.559 28.777 1.00 95.89 C \\\\nATOM 414 O GLU A 52 -25.407 6.653 26.302 1.00 95.89 O \\\\nATOM 415 CG GLU A 52 -24.640 7.275 29.454 1.00 95.89 C \\\\nATOM 416 CD GLU A 52 -24.390 7.180 30.966 1.00 95.89 C \\\\nATOM 417 OE1 GLU A 52 -24.482 6.043 31.488 1.00 95.89 O \\\\nATOM 418 OE2 GLU A 52 -24.034 8.174 31.642 1.00 95.89 O \\\\nATOM 419 N LYS A 53 -26.214 8.750 26.274 1.00 96.28 N \\\\nATOM 420 CA LYS A 53 -27.424 8.464 25.493 1.00 96.28 C \\\\nATOM 421 C LYS A 53 -27.110 7.912 24.098 1.00 96.28 C \\\\nATOM 422 CB LYS A 53 -28.249 9.752 25.426 1.00 96.28 C \\\\nATOM 423 O LYS A 53 -27.704 6.910 23.710 1.00 96.28 O \\\\nATOM 424 CG LYS A 53 -29.588 9.592 24.694 1.00 96.28 C \\\\nATOM 425 CD LYS A 53 -30.278 10.958 24.673 1.00 96.28 C \\\\nATOM 426 CE LYS A 53 -31.551 10.955 23.829 1.00 96.28 C \\\\nATOM 427 NZ LYS A 53 -32.033 12.348 23.670 1.00 96.28 N \\\\nATOM 428 N ALA A 54 -26.183 8.509 23.347 1.00 96.62 N \\\\nATOM 429 CA ALA A 54 -25.789 8.024 22.020 1.00 96.62 C \\\\nATOM 430 C ALA A 54 -25.207 6.605 22.072 1.00 96.62 C \\\\nATOM 431 CB ALA A 54 -24.807 9.023 21.396 1.00 96.62 C \\\\nATOM 432 O ALA A 54 -25.616 5.742 21.298 1.00 96.62 O \\\\nATOM 433 N ILE A 55 -24.307 6.335 23.022 1.00 96.30 N \\\\nATOM 434 CA ILE A 55 -23.681 5.018 23.186 1.00 96.30 C \\\\nATOM 435 C ILE A 55 -24.688 3.949 23.637 1.00 96.30 C \\\\nATOM 436 CB ILE A 55 -22.447 5.125 24.110 1.00 96.30 C \\\\nATOM 437 O ILE A 55 -24.665 2.845 23.099 1.00 96.30 O \\\\nATOM 438 CG1 ILE A 55 -21.331 6.033 23.539 1.00 96.30 C \\\\nATOM 439 CG2 ILE A 55 -21.849 3.744 24.414 1.00 96.30 C \\\\nATOM 440 CD1 ILE A 55 -20.863 5.722 22.113 1.00 96.30 C \\\\nATOM 441 N THR A 56 -25.581 4.270 24.577 1.00 95.54 N \\\\nATOM 442 CA THR A 56 -26.559 3.307 25.119 1.00 95.54 C \\\\nATOM 443 C THR A 56 -27.722 3.023 24.169 1.00 95.54 C \\\\nATOM 444 CB THR A 56 -27.124 3.769 26.470 1.00 95.54 C \\\\nATOM 445 O THR A 56 -28.125 1.871 24.038 1.00 95.54 O \\\\nATOM 446 CG2 THR A 56 -26.083 3.724 27.588 1.00 95.54 C \\\\nATOM 447 OG1 THR A 56 -27.596 5.093 26.403 1.00 95.54 O \\\\nATOM 448 N THR A 57 -28.254 4.044 23.488 1.00 95.70 N \\\\nATOM 449 CA THR A 57 -29.405 3.891 22.573 1.00 95.70 C \\\\nATOM 450 C THR A 57 -29.015 3.477 21.157 1.00 95.70 C \\\\nATOM 451 CB THR A 57 -30.266 5.160 22.486 1.00 95.70 C \\\\nATOM 452 O THR A 57 -29.880 3.040 20.404 1.00 95.70 O \\\\nATOM 453 CG2 THR A 57 -30.814 5.604 23.842 1.00 95.70 C \\\\nATOM 454 OG1 THR A 57 -29.544 6.240 21.937 1.00 95.70 O \\\\nATOM 455 N GLN A 58 -27.740 3.634 20.781 1.00 94.54 N \\\\nATOM 456 CA GLN A 58 -27.207 3.349 19.440 1.00 94.54 C \\\\nATOM 457 C GLN A 58 -27.936 4.101 18.305 1.00 94.54 C \\\\nATOM 458 CB GLN A 58 -27.084 1.828 19.211 1.00 94.54 C \\\\nATOM 459 O GLN A 58 -27.935 3.680 17.149 1.00 94.54 O \\\\nATOM 460 CG GLN A 58 -26.407 1.116 20.396 1.00 94.54 C \\\\nATOM 461 CD GLN A 58 -26.008 -0.329 20.117 1.00 94.54 C \\\\nATOM 462 NE2 GLN A 58 -25.957 -1.152 21.140 1.00 94.54 N \\\\nATOM 463 OE1 GLN A 58 -25.721 -0.762 19.012 1.00 94.54 O \\\\nATOM 464 N ASN A 59 -28.581 5.224 18.639 1.00 92.87 N \\\\nATOM 465 CA ASN A 59 -29.505 5.929 17.759 1.00 92.87 C \\\\nATOM 466 C ASN A 59 -28.807 7.069 16.998 1.00 92.87 C \\\\nATOM 467 CB ASN A 59 -30.705 6.378 18.611 1.00 92.87 C \\\\nATOM 468 O ASN A 59 -28.278 8.009 17.602 1.00 92.87 O \\\\nATOM 469 CG ASN A 59 -31.841 7.012 17.826 1.00 92.87 C \\\\nATOM 470 ND2 ASN A 59 -32.980 7.188 18.452 1.00 92.87 N \\\\nATOM 471 OD1 ASN A 59 -31.741 7.366 16.661 1.00 92.87 O \\\\nATOM 472 N VAL A 60 -28.870 7.013 15.664 1.00 93.35 N \\\\nATOM 473 CA VAL A 60 -28.315 8.020 14.739 1.00 93.35 C \\\\nATOM 474 C VAL A 60 -28.921 9.418 14.934 1.00 93.35 C \\\\nATOM 475 CB VAL A 60 -28.468 7.567 13.270 1.00 93.35 C \\\\nATOM 476 O VAL A 60 -28.242 10.414 14.707 1.00 93.35 O \\\\nATOM 477 CG1 VAL A 60 -27.803 6.203 13.031 1.00 93.35 C \\\\nATOM 478 CG2 VAL A 60 -29.931 7.460 12.812 1.00 93.35 C \\\\nATOM 479 N ASN A 61 -30.156 9.502 15.441 1.00 95.00 N \\\\nATOM 480 CA ASN A 61 -30.888 10.750 15.696 1.00 95.00 C \\\\nATOM 481 C ASN A 61 -30.514 11.426 17.033 1.00 95.00 C \\\\nATOM 482 CB ASN A 61 -32.399 10.475 15.611 1.00 95.00 C \\\\nATOM 483 O ASN A 61 -31.206 12.332 17.498 1.00 95.00 O \\\\nATOM 484 CG ASN A 61 -32.808 9.842 14.297 1.00 95.00 C \\\\nATOM 485 ND2 ASN A 61 -33.213 8.595 14.305 1.00 95.00 N \\\\nATOM 486 OD1 ASN A 61 -32.733 10.444 13.246 1.00 95.00 O \\\\nATOM 487 N THR A 62 -29.454 10.970 17.706 1.00 95.86 N \\\\nATOM 488 CA THR A 62 -28.888 11.690 18.859 1.00 95.86 C \\\\nATOM 489 C THR A 62 -28.145 12.951 18.412 1.00 95.86 C \\\\nATOM 490 CB THR A 62 -28.010 10.785 19.738 1.00 95.86 C \\\\nATOM 491 O THR A 62 -27.816 13.104 17.239 1.00 95.86 O \\\\nATOM 492 CG2 THR A 62 -28.897 9.815 20.518 1.00 95.86 C \\\\nATOM 493 OG1 THR A 62 -27.070 10.038 18.995 1.00 95.86 O \\\\nATOM 494 N LYS A 63 -27.895 13.895 19.330 1.00 96.63 N \\\\nATOM 495 CA LYS A 63 -27.209 15.154 18.992 1.00 96.63 C \\\\nATOM 496 C LYS A 63 -25.744 14.921 18.605 1.00 96.63 C \\\\nATOM 497 CB LYS A 63 -27.314 16.159 20.148 1.00 96.63 C \\\\nATOM 498 O LYS A 63 -25.135 13.909 18.967 1.00 96.63 O \\\\nATOM 499 CG LYS A 63 -28.758 16.609 20.412 1.00 96.63 C \\\\nATOM 500 CD LYS A 63 -28.768 17.696 21.493 1.00 96.63 C \\\\nATOM 501 CE LYS A 63 -30.200 17.996 21.951 1.00 96.63 C \\\\nATOM 502 NZ LYS A 63 -30.233 18.277 23.405 1.00 96.63 N \\\\nATOM 503 N CYS A 64 -25.151 15.889 17.906 1.00 97.45 N \\\\nATOM 504 CA CYS A 64 -23.708 15.899 17.689 1.00 97.45 C \\\\nATOM 505 C CYS A 64 -22.976 16.013 19.035 1.00 97.45 C \\\\nATOM 506 CB CYS A 64 -23.301 17.032 16.736 1.00 97.45 C \\\\nATOM 507 O CYS A 64 -23.277 16.878 19.859 1.00 97.45 O \\\\nATOM 508 SG CYS A 64 -23.929 16.730 15.059 1.00 97.45 S \\\\nATOM 509 N ILE A 65 -21.986 15.145 19.238 1.00 97.88 N \\\\nATOM 510 CA ILE A 65 -21.057 15.214 20.369 1.00 97.88 C \\\\nATOM 511 C ILE A 65 -19.784 15.843 19.833 1.00 97.88 C \\\\nATOM 512 CB ILE A 65 -20.803 13.809 20.959 1.00 97.88 C \\\\nATOM 513 O ILE A 65 -19.086 15.193 19.059 1.00 97.88 O \\\\nATOM 514 CG1 ILE A 65 -22.099 13.076 21.362 1.00 97.88 C \\\\nATOM 515 CG2 ILE A 65 -19.845 13.902 22.156 1.00 97.88 C \\\\nATOM 516 CD1 ILE A 65 -23.002 13.838 22.332 1.00 97.88 C \\\\nATOM 517 N THR A 66 -19.495 17.093 20.178 1.00 97.50 N \\\\nATOM 518 CA THR A 66 -18.403 17.848 19.556 1.00 97.50 C \\\\nATOM 519 C THR A 66 -17.161 17.943 20.436 1.00 97.50 C \\\\nATOM 520 CB THR A 66 -18.853 19.226 19.043 1.00 97.50 C \\\\nATOM 521 O THR A 66 -17.208 17.860 21.663 1.00 97.50 O \\\\nATOM 522 CG2 THR A 66 -19.826 19.092 17.873 1.00 97.50 C \\\\nATOM 523 OG1 THR A 66 -19.484 20.007 20.020 1.00 97.50 O \\\\nATOM 524 N ILE A 67 -16.002 18.076 19.789 1.00 96.58 N \\\\nATOM 525 CA ILE A 67 -14.770 18.550 20.423 1.00 96.58 C \\\\nATOM 526 C ILE A 67 -14.099 19.604 19.526 1.00 96.58 C \\\\nATOM 527 CB ILE A 67 -13.795 17.398 20.776 1.00 96.58 C \\\\nATOM 528 O ILE A 67 -14.213 19.500 18.301 1.00 96.58 O \\\\nATOM 529 CG1 ILE A 67 -13.241 16.667 19.533 1.00 96.58 C \\\\nATOM 530 CG2 ILE A 67 -14.426 16.406 21.772 1.00 96.58 C \\\\nATOM 531 CD1 ILE A 67 -12.138 15.653 19.860 1.00 96.58 C \\\\nATOM 532 N PRO A 68 -13.321 20.546 20.093 1.00 95.38 N \\\\nATOM 533 CA PRO A 68 -12.526 21.483 19.303 1.00 95.38 C \\\\nATOM 534 C PRO A 68 -11.526 20.769 18.386 1.00 95.38 C \\\\nATOM 535 CB PRO A 68 -11.821 22.392 20.315 1.00 95.38 C \\\\nATOM 536 O PRO A 68 -10.821 19.845 18.818 1.00 95.38 O \\\\nATOM 537 CG PRO A 68 -12.757 22.354 21.521 1.00 95.38 C \\\\nATOM 538 CD PRO A 68 -13.292 20.923 21.498 1.00 95.38 C \\\\nATOM 539 N ARG A 69 -11.451 21.219 17.131 1.00 95.13 N \\\\nATOM 540 CA ARG A 69 -10.511 20.757 16.106 1.00 95.13 C \\\\nATOM 541 C ARG A 69 -9.103 21.296 16.394 1.00 95.13 C \\\\nATOM 542 CB ARG A 69 -11.061 21.203 14.735 1.00 95.13 C \\\\nATOM 543 O ARG A 69 -8.932 22.446 16.781 1.00 95.13 O \\\\nATOM 544 CG ARG A 69 -10.229 20.703 13.544 1.00 95.13 C \\\\nATOM 545 CD ARG A 69 -10.828 21.090 12.187 1.00 95.13 C \\\\nATOM 546 NE ARG A 69 -12.138 20.456 11.968 1.00 95.13 N \\\\nATOM 547 NH1 ARG A 69 -11.563 18.720 10.567 1.00 95.13 N \\\\nATOM 548 NH2 ARG A 69 -13.693 19.061 11.108 1.00 95.13 N \\\\nATOM 549 CZ ARG A 69 -12.449 19.415 11.226 1.00 95.13 C \\\\nATOM 550 N SER A 70 -8.076 20.463 16.218 1.00 93.69 N \\\\nATOM 551 CA SER A 70 -6.675 20.911 16.235 1.00 93.69 C \\\\nATOM 552 C SER A 70 -6.253 21.450 14.865 1.00 93.69 C \\\\nATOM 553 CB SER A 70 -5.742 19.766 16.648 1.00 93.69 C \\\\nATOM 554 O SER A 70 -6.850 21.094 13.851 1.00 93.69 O \\\\nATOM 555 OG SER A 70 -5.823 18.716 15.711 1.00 93.69 O \\\\nATOM 556 N LEU A 71 -5.163 22.222 14.818 1.00 90.27 N \\\\nATOM 557 CA LEU A 71 -4.580 22.745 13.570 1.00 90.27 C \\\\nATOM 558 C LEU A 71 -4.316 21.657 12.507 1.00 90.27 C \\\\nATOM 559 CB LEU A 71 -3.256 23.464 13.900 1.00 90.27 C \\\\nATOM 560 O LEU A 71 -4.434 21.918 11.318 1.00 90.27 O \\\\nATOM 561 CG LEU A 71 -3.372 24.686 14.832 1.00 90.27 C \\\\nATOM 562 CD1 LEU A 71 -1.974 25.203 15.173 1.00 90.27 C \\\\nATOM 563 CD2 LEU A 71 -4.171 25.824 14.201 1.00 90.27 C \\\\nATOM 564 N ASP A 72 -3.990 20.431 12.932 1.00 89.02 N \\\\nATOM 565 CA ASP A 72 -3.747 19.272 12.060 1.00 89.02 C \\\\nATOM 566 C ASP A 72 -4.926 18.276 11.996 1.00 89.02 C \\\\nATOM 567 CB ASP A 72 -2.433 18.589 12.485 1.00 89.02 C \\\\nATOM 568 O ASP A 72 -4.781 17.172 11.472 1.00 89.02 O \\\\nATOM 569 CG ASP A 72 -2.514 17.778 13.788 1.00 89.02 C \\\\nATOM 570 OD1 ASP A 72 -3.458 17.970 14.592 1.00 89.02 O \\\\nATOM 571 OD2 ASP A 72 -1.606 16.927 13.988 1.00 89.02 O \\\\nATOM 572 N GLY A 73 -6.075 18.615 12.589 1.00 90.68 N \\\\nATOM 573 CA GLY A 73 -7.268 17.767 12.680 1.00 90.68 C \\\\nATOM 574 C GLY A 73 -7.142 16.496 13.539 1.00 90.68 C \\\\nATOM 575 O GLY A 73 -8.121 15.751 13.646 1.00 90.68 O \\\\nATOM 576 N ARG A 74 -5.982 16.216 14.152 1.00 92.97 N \\\\nATOM 577 CA ARG A 74 -5.710 14.993 14.927 1.00 92.97 C \\\\nATOM 578 C ARG A 74 -5.775 15.211 16.439 1.00 92.97 C \\\\nATOM 579 CB ARG A 74 -4.347 14.404 14.541 1.00 92.97 C \\\\nATOM 580 O ARG A 74 -5.153 16.105 17.007 1.00 92.97 O \\\\nATOM 581 CG ARG A 74 -4.292 13.941 13.076 1.00 92.97 C \\\\nATOM 582 CD ARG A 74 -2.922 13.364 12.704 1.00 92.97 C \\\\nATOM 583 NE ARG A 74 -1.854 14.364 12.867 1.00 92.97 N \\\\nATOM 584 NH1 ARG A 74 -0.127 13.265 11.816 1.00 92.97 N \\\\nATOM 585 NH2 ARG A 74 0.142 15.350 12.593 1.00 92.97 N \\\\nATOM 586 CZ ARG A 74 -0.619 14.312 12.419 1.00 92.97 C \\\\nATOM 587 N LEU A 75 -6.436 14.284 17.124 1.00 94.38 N \\\\nATOM 588 CA LEU A 75 -6.420 14.175 18.577 1.00 94.38 C \\\\nATOM 589 C LEU A 75 -5.216 13.339 19.036 1.00 94.38 C \\\\nATOM 590 CB LEU A 75 -7.766 13.584 19.026 1.00 94.38 C \\\\nATOM 591 O LEU A 75 -4.989 12.231 18.547 1.00 94.38 O \\\\nATOM 592 CG LEU A 75 -7.917 13.386 20.543 1.00 94.38 C \\\\nATOM 593 CD1 LEU A 75 -7.888 14.711 21.312 1.00 94.38 C \\\\nATOM 594 CD2 LEU A 75 -9.250 12.703 20.838 1.00 94.38 C \\\\nATOM 595 N GLN A 76 -4.470 13.843 20.021 1.00 93.91 N \\\\nATOM 596 CA GLN A 76 -3.434 13.075 20.711 1.00 93.91 C \\\\nATOM 597 C GLN A 76 -4.001 12.383 21.959 1.00 93.91 C \\\\nATOM 598 CB GLN A 76 -2.228 13.973 21.025 1.00 93.91 C \\\\nATOM 599 O GLN A 76 -4.605 13.023 22.821 1.00 93.91 O \\\\nATOM 600 CG GLN A 76 -1.059 13.148 21.595 1.00 93.91 C \\\\nATOM 601 CD GLN A 76 0.254 13.919 21.672 1.00 93.91 C \\\\nATOM 602 NE2 GLN A 76 1.165 13.490 22.517 1.00 93.91 N \\\\nATOM 603 OE1 GLN A 76 0.496 14.875 20.951 1.00 93.91 O \\\\nATOM 604 N VAL A 77 -3.755 11.077 22.078 1.00 91.95 N \\\\nATOM 605 CA VAL A 77 -4.080 10.257 23.252 1.00 91.95 C \\\\nATOM 606 C VAL A 77 -2.822 9.505 23.690 1.00 91.95 C \\\\nATOM 607 CB VAL A 77 -5.244 9.286 22.969 1.00 91.95 C \\\\nATOM 608 O VAL A 77 -2.366 8.565 23.031 1.00 91.95 O \\\\nATOM 609 CG1 VAL A 77 -5.582 8.478 24.229 1.00 91.95 C \\\\nATOM 610 CG2 VAL A 77 -6.518 10.015 22.520 1.00 91.95 C \\\\nATOM 611 N SER A 78 -2.256 9.910 24.831 1.00 89.64 N \\\\nATOM 612 CA SER A 78 -0.940 9.453 25.304 1.00 89.64 C \\\\nATOM 613 C SER A 78 0.139 9.719 24.234 1.00 89.64 C \\\\nATOM 614 CB SER A 78 -1.034 7.999 25.813 1.00 89.64 C \\\\nATOM 615 O SER A 78 0.383 10.877 23.894 1.00 89.64 O \\\\nATOM 616 OG SER A 78 -0.107 7.700 26.853 1.00 89.64 O \\\\nATOM 617 N HIS A 79 0.750 8.669 23.679 1.00 87.62 N \\\\nATOM 618 CA HIS A 79 1.822 8.748 22.677 1.00 87.62 C \\\\nATOM 619 C HIS A 79 1.325 8.524 21.236 1.00 87.62 C \\\\nATOM 620 CB HIS A 79 2.944 7.764 23.061 1.00 87.62 C \\\\nATOM 621 O HIS A 79 2.130 8.502 20.315 1.00 87.62 O \\\\nATOM 622 CG HIS A 79 3.317 7.846 24.520 1.00 87.62 C \\\\nATOM 623 CD2 HIS A 79 2.824 7.047 25.515 1.00 87.62 C \\\\nATOM 624 ND1 HIS A 79 4.077 8.821 25.124 1.00 87.62 N \\\\nATOM 625 CE1 HIS A 79 4.026 8.622 26.453 1.00 87.62 C \\\\nATOM 626 NE2 HIS A 79 3.222 7.582 26.741 1.00 87.62 N \\\\nATOM 627 N ARG A 80 0.011 8.342 21.023 1.00 89.06 N \\\\nATOM 628 CA ARG A 80 -0.589 8.120 19.695 1.00 89.06 C \\\\nATOM 629 C ARG A 80 -1.371 9.360 19.252 1.00 89.06 C \\\\nATOM 630 CB ARG A 80 -1.469 6.850 19.695 1.00 89.06 C \\\\nATOM 631 O ARG A 80 -2.094 9.946 20.059 1.00 89.06 O \\\\nATOM 632 CG ARG A 80 -0.694 5.556 20.025 1.00 89.06 C \\\\nATOM 633 CD ARG A 80 -1.591 4.306 19.924 1.00 89.06 C \\\\nATOM 634 NE ARG A 80 -0.844 3.050 20.173 1.00 89.06 N \\\\nATOM 635 NH1 ARG A 80 -2.641 1.599 20.215 1.00 89.06 N \\\\nATOM 636 NH2 ARG A 80 -0.578 0.789 20.395 1.00 89.06 N \\\\nATOM 637 CZ ARG A 80 -1.357 1.827 20.262 1.00 89.06 C \\\\nATOM 638 N LYS A 81 -1.257 9.740 17.976 1.00 91.08 N \\\\nATOM 639 CA LYS A 81 -2.114 10.740 17.313 1.00 91.08 C \\\\nATOM 640 C LYS A 81 -3.033 10.033 16.320 1.00 91.08 C \\\\nATOM 641 CB LYS A 81 -1.278 11.818 16.596 1.00 91.08 C \\\\nATOM 642 O LYS A 81 -2.574 9.153 15.603 1.00 91.08 O \\\\nATOM 643 CG LYS A 81 -0.553 12.772 17.558 1.00 91.08 C \\\\nATOM 644 CD LYS A 81 0.071 13.948 16.788 1.00 91.08 C \\\\nATOM 645 CE LYS A 81 0.707 14.966 17.745 1.00 91.08 C \\\\nATOM 646 NZ LYS A 81 1.119 16.202 17.030 1.00 91.08 N \\\\nATOM 647 N GLY A 82 -4.296 10.436 16.252 1.00 92.21 N \\\\nATOM 648 CA GLY A 82 -5.266 9.886 15.305 1.00 92.21 C \\\\nATOM 649 C GLY A 82 -6.428 10.841 15.063 1.00 92.21 C \\\\nATOM 650 O GLY A 82 -6.586 11.836 15.770 1.00 92.21 O \\\\nATOM 651 N LEU A 83 -7.242 10.562 14.049 1.00 94.68 N \\\\nATOM 652 CA LEU A 83 -8.426 11.370 13.766 1.00 94.68 C \\\\nATOM 653 C LEU A 83 -9.513 11.089 14.819 1.00 94.68 C \\\\nATOM 654 CB LEU A 83 -8.899 11.097 12.332 1.00 94.68 C \\\\nATOM 655 O LEU A 83 -9.783 9.923 15.107 1.00 94.68 O \\\\nATOM 656 CG LEU A 83 -7.914 11.591 11.254 1.00 94.68 C \\\\nATOM 657 CD1 LEU A 83 -8.412 11.182 9.874 1.00 94.68 C \\\\nATOM 658 CD2 LEU A 83 -7.753 13.111 11.288 1.00 94.68 C \\\\nATOM 659 N PRO A 84 -10.135 12.117 15.424 1.00 96.13 N \\\\nATOM 660 CA PRO A 84 -10.963 11.926 16.613 1.00 96.13 C \\\\nATOM 661 C PRO A 84 -12.207 11.073 16.345 1.00 96.13 C \\\\nATOM 662 CB PRO A 84 -11.291 13.335 17.107 1.00 96.13 C \\\\nATOM 663 O PRO A 84 -12.475 10.141 17.096 1.00 96.13 O \\\\nATOM 664 CG PRO A 84 -11.097 14.233 15.887 1.00 96.13 C \\\\nATOM 665 CD PRO A 84 -9.985 13.531 15.117 1.00 96.13 C \\\\nATOM 666 N HIS A 85 -12.917 11.321 15.245 1.00 96.28 N \\\\nATOM 667 CA HIS A 85 -14.066 10.508 14.841 1.00 96.28 C \\\\nATOM 668 C HIS A 85 -13.681 9.035 14.599 1.00 96.28 C \\\\nATOM 669 CB HIS A 85 -14.733 11.152 13.620 1.00 96.28 C \\\\nATOM 670 O HIS A 85 -14.369 8.151 15.099 1.00 96.28 O \\\\nATOM 671 CG HIS A 85 -13.853 11.227 12.398 1.00 96.28 C \\\\nATOM 672 CD2 HIS A 85 -13.950 10.425 11.294 1.00 96.28 C \\\\nATOM 673 ND1 HIS A 85 -12.801 12.094 12.184 1.00 96.28 N \\\\nATOM 674 CE1 HIS A 85 -12.266 11.799 10.989 1.00 96.28 C \\\\nATOM 675 NE2 HIS A 85 -12.924 10.787 10.421 1.00 96.28 N \\\\nATOM 676 N VAL A 86 -12.538 8.761 13.950 1.00 95.91 N \\\\nATOM 677 CA VAL A 86 -12.007 7.394 13.763 1.00 95.91 C \\\\nATOM 678 C VAL A 86 -11.714 6.721 15.103 1.00 95.91 C \\\\nATOM 679 CB VAL A 86 -10.731 7.378 12.895 1.00 95.91 C \\\\nATOM 680 O VAL A 86 -12.126 5.586 15.305 1.00 95.91 O \\\\nATOM 681 CG1 VAL A 86 -10.186 5.964 12.647 1.00 95.91 C \\\\nATOM 682 CG2 VAL A 86 -10.992 7.999 11.526 1.00 95.91 C \\\\nATOM 683 N ILE A 87 -11.056 7.416 16.041 1.00 95.75 N \\\\nATOM 684 CA ILE A 87 -10.737 6.877 17.378 1.00 95.75 C \\\\nATOM 685 C ILE A 87 -12.005 6.382 18.085 1.00 95.75 C \\\\nATOM 686 CB ILE A 87 -9.989 7.938 18.229 1.00 95.75 C \\\\nATOM 687 O ILE A 87 -12.017 5.278 18.627 1.00 95.75 O \\\\nATOM 688 CG1 ILE A 87 -8.549 8.131 17.697 1.00 95.75 C \\\\nATOM 689 CG2 ILE A 87 -9.975 7.568 19.729 1.00 95.75 C \\\\nATOM 690 CD1 ILE A 87 -7.835 9.374 18.251 1.00 95.75 C \\\\nATOM 691 N TYR A 88 -13.070 7.184 18.078 1.00 97.01 N \\\\nATOM 692 CA TYR A 88 -14.292 6.876 18.820 1.00 97.01 C \\\\nATOM 693 C TYR A 88 -15.236 5.921 18.067 1.00 97.01 C \\\\nATOM 694 CB TYR A 88 -14.923 8.197 19.280 1.00 97.01 C \\\\nATOM 695 O TYR A 88 -15.862 5.073 18.706 1.00 97.01 O \\\\nATOM 696 CG TYR A 88 -14.039 8.958 20.269 1.00 97.01 C \\\\nATOM 697 CD1 TYR A 88 -13.650 8.363 21.488 1.00 97.01 C \\\\nATOM 698 CD2 TYR A 88 -13.542 10.235 19.946 1.00 97.01 C \\\\nATOM 699 CE1 TYR A 88 -12.758 9.025 22.356 1.00 97.01 C \\\\nATOM 700 CE2 TYR A 88 -12.657 10.909 20.809 1.00 97.01 C \\\\nATOM 701 OH TYR A 88 -11.359 10.917 22.833 1.00 97.01 O \\\\nATOM 702 CZ TYR A 88 -12.249 10.297 22.010 1.00 97.01 C \\\\nATOM 703 N CYS A 89 -15.259 5.944 16.728 1.00 97.14 N \\\\nATOM 704 CA CYS A 89 -15.911 4.899 15.927 1.00 97.14 C \\\\nATOM 705 C CYS A 89 -15.223 3.538 16.102 1.00 97.14 C \\\\nATOM 706 CB CYS A 89 -15.940 5.300 14.446 1.00 97.14 C \\\\nATOM 707 O CYS A 89 -15.909 2.531 16.282 1.00 97.14 O \\\\nATOM 708 SG CYS A 89 -17.012 6.741 14.207 1.00 97.14 S \\\\nATOM 709 N ARG A 90 -13.881 3.502 16.131 1.00 94.96 N \\\\nATOM 710 CA ARG A 90 -13.118 2.270 16.374 1.00 94.96 C \\\\nATOM 711 C ARG A 90 -13.416 1.683 17.753 1.00 94.96 C \\\\nATOM 712 CB ARG A 90 -11.610 2.504 16.148 1.00 94.96 C \\\\nATOM 713 O ARG A 90 -13.631 0.485 17.889 1.00 94.96 O \\\\nATOM 714 CG ARG A 90 -10.822 1.179 16.147 1.00 94.96 C \\\\nATOM 715 CD ARG A 90 -9.299 1.349 16.072 1.00 94.96 C \\\\nATOM 716 NE ARG A 90 -8.859 1.913 14.783 1.00 94.96 N \\\\nATOM 717 NH1 ARG A 90 -6.593 1.849 15.128 1.00 94.96 N \\\\nATOM 718 NH2 ARG A 90 -7.394 2.582 13.182 1.00 94.96 N \\\\nATOM 719 CZ ARG A 90 -7.620 2.119 14.376 1.00 94.96 C \\\\nATOM 720 N LEU A 91 -13.475 2.541 18.774 1.00 95.35 N \\\\nATOM 721 CA LEU A 91 -13.684 2.125 20.161 1.00 95.35 C \\\\nATOM 722 C LEU A 91 -15.085 1.529 20.399 1.00 95.35 C \\\\nATOM 723 CB LEU A 91 -13.349 3.325 21.071 1.00 95.35 C \\\\nATOM 724 O LEU A 91 -15.193 0.505 21.071 1.00 95.35 O \\\\nATOM 725 CG LEU A 91 -13.069 2.959 22.541 1.00 95.35 C \\\\nATOM 726 CD1 LEU A 91 -12.143 4.000 23.179 1.00 95.35 C \\\\nATOM 727 CD2 LEU A 91 -14.329 2.914 23.405 1.00 95.35 C \\\\nATOM 728 N TRP A 92 -16.144 2.141 19.854 1.00 96.60 N \\\\nATOM 729 CA TRP A 92 -17.537 1.766 20.157 1.00 96.60 C \\\\nATOM 730 C TRP A 92 -18.284 0.994 19.062 1.00 96.60 C \\\\nATOM 731 CB TRP A 92 -18.313 3.021 20.582 1.00 96.60 C \\\\nATOM 732 O TRP A 92 -19.358 0.464 19.347 1.00 96.60 O \\\\nATOM 733 CG TRP A 92 -17.957 3.535 21.942 1.00 96.60 C \\\\nATOM 734 CD1 TRP A 92 -18.066 2.819 23.082 1.00 96.60 C \\\\nATOM 735 CD2 TRP A 92 -17.462 4.850 22.345 1.00 96.60 C \\\\nATOM 736 CE2 TRP A 92 -17.256 4.832 23.759 1.00 96.60 C \\\\nATOM 737 CE3 TRP A 92 -17.178 6.059 21.672 1.00 96.60 C \\\\nATOM 738 NE1 TRP A 92 -17.647 3.572 24.156 1.00 96.60 N \\\\nATOM 739 CH2 TRP A 92 -16.458 7.112 23.753 1.00 96.60 C \\\\nATOM 740 CZ2 TRP A 92 -16.732 5.930 24.453 1.00 96.60 C \\\\nATOM 741 CZ3 TRP A 92 -16.710 7.188 22.373 1.00 96.60 C \\\\nATOM 742 N ARG A 93 -17.759 0.902 17.831 1.00 95.15 N \\\\nATOM 743 CA ARG A 93 -18.455 0.233 16.712 1.00 95.15 C \\\\nATOM 744 C ARG A 93 -17.601 -0.788 15.968 1.00 95.15 C \\\\nATOM 745 CB ARG A 93 -19.070 1.267 15.755 1.00 95.15 C \\\\nATOM 746 O ARG A 93 -17.990 -1.951 15.932 1.00 95.15 O \\\\nATOM 747 CG ARG A 93 -20.137 2.119 16.462 1.00 95.15 C \\\\nATOM 748 CD ARG A 93 -20.863 3.041 15.485 1.00 95.15 C \\\\nATOM 749 NE ARG A 93 -21.743 2.298 14.563 1.00 95.15 N \\\\nATOM 750 NH1 ARG A 93 -22.348 4.110 13.332 1.00 95.15 N \\\\nATOM 751 NH2 ARG A 93 -23.186 2.127 12.794 1.00 95.15 N \\\\nATOM 752 CZ ARG A 93 -22.420 2.840 13.570 1.00 95.15 C \\\\nATOM 753 N TRP A 94 -16.461 -0.377 15.415 1.00 94.17 N \\\\nATOM 754 CA TRP A 94 -15.676 -1.193 14.474 1.00 94.17 C \\\\nATOM 755 C TRP A 94 -14.194 -1.247 14.882 1.00 94.17 C \\\\nATOM 756 CB TRP A 94 -15.855 -0.623 13.061 1.00 94.17 C \\\\nATOM 757 O TRP A 94 -13.423 -0.380 14.469 1.00 94.17 O \\\\nATOM 758 CG TRP A 94 -17.264 -0.527 12.567 1.00 94.17 C \\\\nATOM 759 CD1 TRP A 94 -18.073 -1.569 12.277 1.00 94.17 C \\\\nATOM 760 CD2 TRP A 94 -18.039 0.675 12.283 1.00 94.17 C \\\\nATOM 761 CE2 TRP A 94 -19.324 0.281 11.803 1.00 94.17 C \\\\nATOM 762 CE3 TRP A 94 -17.778 2.060 12.376 1.00 94.17 C \\\\nATOM 763 NE1 TRP A 94 -19.289 -1.098 11.818 1.00 94.17 N \\\\nATOM 764 CH2 TRP A 94 -19.992 2.588 11.501 1.00 94.17 C \\\\nATOM 765 CZ2 TRP A 94 -20.291 1.216 11.407 1.00 94.17 C \\\\nATOM 766 CZ3 TRP A 94 -18.748 3.008 11.999 1.00 94.17 C \\\\nATOM 767 N PRO A 95 -13.767 -2.218 15.713 1.00 91.85 N \\\\nATOM 768 CA PRO A 95 -12.377 -2.334 16.180 1.00 91.85 C \\\\nATOM 769 C PRO A 95 -11.349 -2.409 15.044 1.00 91.85 C \\\\nATOM 770 CB PRO A 95 -12.335 -3.624 17.007 1.00 91.85 C \\\\nATOM 771 O PRO A 95 -10.232 -1.917 15.177 1.00 91.85 O \\\\nATOM 772 CG PRO A 95 -13.776 -3.784 17.471 1.00 91.85 C \\\\nATOM 773 CD PRO A 95 -14.589 -3.261 16.296 1.00 91.85 C \\\\nATOM 774 N ASP A 96 -11.778 -2.981 13.924 1.00 88.11 N \\\\nATOM 775 CA ASP A 96 -11.075 -3.212 12.665 1.00 88.11 C \\\\nATOM 776 C ASP A 96 -11.137 -2.021 11.684 1.00 88.11 C \\\\nATOM 777 CB ASP A 96 -11.697 -4.475 12.048 1.00 88.11 C \\\\nATOM 778 O ASP A 96 -10.795 -2.157 10.514 1.00 88.11 O \\\\nATOM 779 CG ASP A 96 -13.152 -4.244 11.620 1.00 88.11 C \\\\nATOM 780 OD1 ASP A 96 -13.968 -3.756 12.443 1.00 88.11 O \\\\nATOM 781 OD2 ASP A 96 -13.460 -4.509 10.440 1.00 88.11 O \\\\nATOM 782 N LEU A 97 -11.589 -0.845 12.128 1.00 90.03 N \\\\nATOM 783 CA LEU A 97 -11.603 0.378 11.321 1.00 90.03 C \\\\nATOM 784 C LEU A 97 -10.190 0.968 11.204 1.00 90.03 C \\\\nATOM 785 CB LEU A 97 -12.558 1.369 12.005 1.00 90.03 C \\\\nATOM 786 O LEU A 97 -9.690 1.539 12.177 1.00 90.03 O \\\\nATOM 787 CG LEU A 97 -12.699 2.703 11.262 1.00 90.03 C \\\\nATOM 788 CD1 LEU A 97 -13.601 2.541 10.045 1.00 90.03 C \\\\nATOM 789 CD2 LEU A 97 -13.313 3.751 12.188 1.00 90.03 C \\\\nATOM 790 N HIS A 98 -9.561 0.935 10.034 1.00 83.53 N \\\\nATOM 791 CA HIS A 98 -8.185 1.398 9.822 1.00 83.53 C \\\\nATOM 792 C HIS A 98 -8.109 2.885 9.443 1.00 83.53 C \\\\nATOM 793 CB HIS A 98 -7.491 0.500 8.787 1.00 83.53 C \\\\nATOM 794 O HIS A 98 -7.307 3.624 10.024 1.00 83.53 O \\\\nATOM 795 CG HIS A 98 -7.350 -0.918 9.279 1.00 83.53 C \\\\nATOM 796 CD2 HIS A 98 -6.292 -1.441 9.975 1.00 83.53 C \\\\nATOM 797 ND1 HIS A 98 -8.318 -1.894 9.231 1.00 83.53 N \\\\nATOM 798 CE1 HIS A 98 -7.867 -2.964 9.902 1.00 83.53 C \\\\nATOM 799 NE2 HIS A 98 -6.648 -2.722 10.403 1.00 83.53 N \\\\nATOM 800 N SER A 99 -8.966 3.349 8.528 1.00 85.84 N \\\\nATOM 801 CA SER A 99 -8.930 4.700 7.946 1.00 85.84 C \\\\nATOM 802 C SER A 99 -10.231 5.484 8.140 1.00 85.84 C \\\\nATOM 803 CB SER A 99 -8.601 4.601 6.452 1.00 85.84 C \\\\nATOM 804 O SER A 99 -11.318 4.925 8.226 1.00 85.84 O \\\\nATOM 805 OG SER A 99 -8.411 5.893 5.882 1.00 85.84 O \\\\nATOM 806 N HIS A 100 -10.141 6.818 8.123 1.00 89.28 N \\\\nATOM 807 CA HIS A 100 -11.322 7.683 7.992 1.00 89.28 C \\\\nATOM 808 C HIS A 100 -12.066 7.522 6.664 1.00 89.28 C \\\\nATOM 809 CB HIS A 100 -10.934 9.152 8.163 1.00 89.28 C \\\\nATOM 810 O HIS A 100 -13.252 7.814 6.608 1.00 89.28 O \\\\nATOM 811 CG HIS A 100 -10.106 9.767 7.057 1.00 89.28 C \\\\nATOM 812 CD2 HIS A 100 -10.271 11.039 6.582 1.00 89.28 C \\\\nATOM 813 ND1 HIS A 100 -9.054 9.208 6.355 1.00 89.28 N \\\\nATOM 814 CE1 HIS A 100 -8.602 10.136 5.494 1.00 89.28 C \\\\nATOM 815 NE2 HIS A 100 -9.290 11.280 5.620 1.00 89.28 N \\\\nATOM 816 N HIS A 101 -11.389 7.043 5.617 1.00 87.61 N \\\\nATOM 817 CA HIS A 101 -11.995 6.815 4.305 1.00 87.61 C \\\\nATOM 818 C HIS A 101 -13.023 5.667 4.339 1.00 87.61 C \\\\nATOM 819 CB HIS A 101 -10.877 6.550 3.288 1.00 87.61 C \\\\nATOM 820 O HIS A 101 -13.914 5.620 3.502 1.00 87.61 O \\\\nATOM 821 CG HIS A 101 -9.903 7.679 3.043 1.00 87.61 C \\\\nATOM 822 CD2 HIS A 101 -8.576 7.525 2.753 1.00 87.61 C \\\\nATOM 823 ND1 HIS A 101 -10.253 9.008 2.824 1.00 87.61 N \\\\nATOM 824 CE1 HIS A 101 -9.148 9.614 2.366 1.00 87.61 C \\\\nATOM 825 NE2 HIS A 101 -8.114 8.755 2.330 1.00 87.61 N \\\\nATOM 826 N GLU A 102 -12.947 4.778 5.340 1.00 91.34 N \\\\nATOM 827 CA GLU A 102 -13.962 3.748 5.612 1.00 91.34 C \\\\nATOM 828 C GLU A 102 -15.215 4.320 6.298 1.00 91.34 C \\\\nATOM 829 CB GLU A 102 -13.376 2.657 6.521 1.00 91.34 C \\\\nATOM 830 O GLU A 102 -16.148 3.567 6.567 1.00 91.34 O \\\\nATOM 831 CG GLU A 102 -12.282 1.772 5.924 1.00 91.34 C \\\\nATOM 832 CD GLU A 102 -11.709 0.897 7.044 1.00 91.34 C \\\\nATOM 833 OE1 GLU A 102 -10.610 1.257 7.528 1.00 91.34 O \\\\nATOM 834 OE2 GLU A 102 -12.403 -0.044 7.507 1.00 91.34 O \\\\nATOM 835 N LEU A 103 -15.260 5.621 6.617 1.00 94.44 N \\\\nATOM 836 CA LEU A 103 -16.401 6.278 7.252 1.00 94.44 C \\\\nATOM 837 C LEU A 103 -17.027 7.334 6.336 1.00 94.44 C \\\\nATOM 838 CB LEU A 103 -15.993 6.932 8.583 1.00 94.44 C \\\\nATOM 839 O LEU A 103 -16.368 8.273 5.892 1.00 94.44 O \\\\nATOM 840 CG LEU A 103 -15.497 5.984 9.685 1.00 94.44 C \\\\nATOM 841 CD1 LEU A 103 -15.192 6.821 10.931 1.00 94.44 C \\\\nATOM 842 CD2 LEU A 103 -16.527 4.918 10.060 1.00 94.44 C \\\\nATOM 843 N ARG A 104 -18.346 7.257 6.169 1.00 93.98 N \\\\nATOM 844 CA ARG A 104 -19.178 8.341 5.637 1.00 93.98 C \\\\nATOM 845 C ARG A 104 -19.914 9.007 6.796 1.00 93.98 C \\\\nATOM 846 CB ARG A 104 -20.119 7.758 4.574 1.00 93.98 C \\\\nATOM 847 O ARG A 104 -20.406 8.315 7.679 1.00 93.98 O \\\\nATOM 848 CG ARG A 104 -20.871 8.846 3.792 1.00 93.98 C \\\\nATOM 849 CD ARG A 104 -21.746 8.249 2.682 1.00 93.98 C \\\\nATOM 850 NE ARG A 104 -20.942 7.590 1.630 1.00 93.98 N \\\\nATOM 851 NH1 ARG A 104 -22.690 6.672 0.453 1.00 93.98 N \\\\nATOM 852 NH2 ARG A 104 -20.597 6.298 -0.217 1.00 93.98 N \\\\nATOM 853 CZ ARG A 104 -21.412 6.861 0.631 1.00 93.98 C \\\\nATOM 854 N ALA A 105 -19.987 10.334 6.832 1.00 95.58 N \\\\nATOM 855 CA ALA A 105 -20.825 11.016 7.817 1.00 95.58 C \\\\nATOM 856 C ALA A 105 -22.312 10.886 7.449 1.00 95.58 C \\\\nATOM 857 CB ALA A 105 -20.386 12.473 7.934 1.00 95.58 C \\\\nATOM 858 O ALA A 105 -22.654 10.912 6.269 1.00 95.58 O \\\\nATOM 859 N MET A 106 -23.180 10.771 8.454 1.00 94.73 N \\\\nATOM 860 CA MET A 106 -24.633 10.840 8.263 1.00 94.73 C \\\\nATOM 861 C MET A 106 -25.040 12.262 7.857 1.00 94.73 C \\\\nATOM 862 CB MET A 106 -25.367 10.441 9.556 1.00 94.73 C \\\\nATOM 863 O MET A 106 -24.473 13.227 8.368 1.00 94.73 O \\\\nATOM 864 CG MET A 106 -25.076 9.008 10.024 1.00 94.73 C \\\\nATOM 865 SD MET A 106 -25.501 7.677 8.871 1.00 94.73 S \\\\nATOM 866 CE MET A 106 -27.310 7.807 8.826 1.00 94.73 C \\\\nATOM 867 N GLU A 107 -26.060 12.403 7.010 1.00 93.15 N \\\\nATOM 868 CA GLU A 107 -26.558 13.710 6.533 1.00 93.15 C \\\\nATOM 869 C GLU A 107 -27.026 14.628 7.677 1.00 93.15 C \\\\nATOM 870 CB GLU A 107 -27.710 13.476 5.544 1.00 93.15 C \\\\nATOM 871 O GLU A 107 -26.850 15.841 7.622 1.00 93.15 O \\\\nATOM 872 CG GLU A 107 -27.247 12.693 4.303 1.00 93.15 C \\\\nATOM 873 CD GLU A 107 -28.367 12.438 3.284 1.00 93.15 C \\\\nATOM 874 OE1 GLU A 107 -28.010 11.970 2.181 1.00 93.15 O \\\\nATOM 875 OE2 GLU A 107 -29.546 12.670 3.630 1.00 93.15 O \\\\nATOM 876 N LEU A 108 -27.527 14.035 8.765 1.00 93.69 N \\\\nATOM 877 CA LEU A 108 -27.938 14.715 10.001 1.00 93.69 C \\\\nATOM 878 C LEU A 108 -26.760 15.276 10.835 1.00 93.69 C \\\\nATOM 879 CB LEU A 108 -28.760 13.713 10.841 1.00 93.69 C \\\\nATOM 880 O LEU A 108 -26.981 15.903 11.870 1.00 93.69 O \\\\nATOM 881 CG LEU A 108 -30.059 13.205 10.182 1.00 93.69 C \\\\nATOM 882 CD1 LEU A 108 -30.610 12.023 10.982 1.00 93.69 C \\\\nATOM 883 CD2 LEU A 108 -31.133 14.292 10.122 1.00 93.69 C \\\\nATOM 884 N CYS A 109 -25.503 15.021 10.455 1.00 96.21 N \\\\nATOM 885 CA CYS A 109 -24.330 15.402 11.242 1.00 96.21 C \\\\nATOM 886 C CYS A 109 -23.824 16.809 10.888 1.00 96.21 C \\\\nATOM 887 CB CYS A 109 -23.247 14.332 11.086 1.00 96.21 C \\\\nATOM 888 O CYS A 109 -22.939 16.987 10.050 1.00 96.21 O \\\\nATOM 889 SG CYS A 109 -21.880 14.671 12.240 1.00 96.21 S \\\\nATOM 890 N GLU A 110 -24.309 17.816 11.614 1.00 96.46 N \\\\nATOM 891 CA GLU A 110 -23.943 19.229 11.425 1.00 96.46 C \\\\nATOM 892 C GLU A 110 -22.450 19.545 11.646 1.00 96.46 C \\\\nATOM 893 CB GLU A 110 -24.740 20.085 12.415 1.00 96.46 C \\\\nATOM 894 O GLU A 110 -21.980 20.613 11.249 1.00 96.46 O \\\\nATOM 895 CG GLU A 110 -26.263 19.981 12.271 1.00 96.46 C \\\\nATOM 896 CD GLU A 110 -26.979 20.882 13.289 1.00 96.46 C \\\\nATOM 897 OE1 GLU A 110 -28.101 21.328 12.975 1.00 96.46 O \\\\nATOM 898 OE2 GLU A 110 -26.391 21.128 14.371 1.00 96.46 O \\\\nATOM 899 N PHE A 111 -21.695 18.655 12.297 1.00 97.34 N \\\\nATOM 900 CA PHE A 111 -20.281 18.845 12.653 1.00 97.34 C \\\\nATOM 901 C PHE A 111 -19.386 17.721 12.109 1.00 97.34 C \\\\nATOM 902 CB PHE A 111 -20.146 19.067 14.169 1.00 97.34 C \\\\nATOM 903 O PHE A 111 -18.363 17.375 12.709 1.00 97.34 O \\\\nATOM 904 CG PHE A 111 -20.828 20.321 14.674 1.00 97.34 C \\\\nATOM 905 CD1 PHE A 111 -20.106 21.524 14.784 1.00 97.34 C \\\\nATOM 906 CD2 PHE A 111 -22.187 20.286 15.038 1.00 97.34 C \\\\nATOM 907 CE1 PHE A 111 -20.739 22.681 15.274 1.00 97.34 C \\\\nATOM 908 CE2 PHE A 111 -22.828 21.447 15.497 1.00 97.34 C \\\\nATOM 909 CZ PHE A 111 -22.101 22.642 15.627 1.00 97.34 C \\\\nATOM 910 N ALA A 112 -19.768 17.115 10.985 1.00 95.98 N \\\\nATOM 911 CA ALA A 112 -19.009 16.040 10.359 1.00 95.98 C \\\\nATOM 912 C ALA A 112 -17.552 16.444 10.052 1.00 95.98 C \\\\nATOM 913 CB ALA A 112 -19.760 15.597 9.106 1.00 95.98 C \\\\nATOM 914 O ALA A 112 -17.249 17.588 9.699 1.00 95.98 O \\\\nATOM 915 N PHE A 113 -16.612 15.499 10.184 1.00 93.94 N \\\\nATOM 916 CA PHE A 113 -15.178 15.800 10.078 1.00 93.94 C \\\\nATOM 917 C PHE A 113 -14.775 16.480 8.756 1.00 93.94 C \\\\nATOM 918 CB PHE A 113 -14.367 14.516 10.278 1.00 93.94 C \\\\nATOM 919 O PHE A 113 -13.932 17.385 8.777 1.00 93.94 O \\\\nATOM 920 CG PHE A 113 -12.874 14.717 10.076 1.00 93.94 C \\\\nATOM 921 CD1 PHE A 113 -12.257 14.293 8.882 1.00 93.94 C \\\\nATOM 922 CD2 PHE A 113 -12.103 15.355 11.066 1.00 93.94 C \\\\nATOM 923 CE1 PHE A 113 -10.881 14.503 8.686 1.00 93.94 C \\\\nATOM 924 CE2 PHE A 113 -10.724 15.550 10.880 1.00 93.94 C \\\\nATOM 925 CZ PHE A 113 -10.117 15.137 9.681 1.00 93.94 C \\\\nATOM 926 N ASN A 114 -15.397 16.080 7.643 1.00 91.30 N \\\\nATOM 927 CA ASN A 114 -15.186 16.613 6.295 1.00 91.30 C \\\\nATOM 928 C ASN A 114 -15.691 18.056 6.101 1.00 91.30 C \\\\nATOM 929 CB ASN A 114 -15.829 15.658 5.264 1.00 91.30 C \\\\nATOM 930 O ASN A 114 -15.181 18.738 5.219 1.00 91.30 O \\\\nATOM 931 CG ASN A 114 -17.340 15.517 5.407 1.00 91.30 C \\\\nATOM 932 ND2 ASN A 114 -18.054 15.240 4.344 1.00 91.30 N \\\\nATOM 933 OD1 ASN A 114 -17.887 15.635 6.490 1.00 91.30 O \\\\nATOM 934 N MET A 115 -16.607 18.556 6.941 1.00 93.28 N \\\\nATOM 935 CA MET A 115 -17.109 19.941 6.870 1.00 93.28 C \\\\nATOM 936 C MET A 115 -16.089 20.993 7.338 1.00 93.28 C \\\\nATOM 937 CB MET A 115 -18.397 20.097 7.694 1.00 93.28 C \\\\nATOM 938 O MET A 115 -16.359 22.185 7.245 1.00 93.28 O \\\\nATOM 939 CG MET A 115 -19.531 19.178 7.245 1.00 93.28 C \\\\nATOM 940 SD MET A 115 -21.011 19.386 8.269 1.00 93.28 S \\\\nATOM 941 CE MET A 115 -22.025 20.428 7.188 1.00 93.28 C \\\\nATOM 942 N LYS A 116 -14.933 20.574 7.879 1.00 91.49 N \\\\nATOM 943 CA LYS A 116 -13.805 21.437 8.299 1.00 91.49 C \\\\nATOM 944 C LYS A 116 -14.143 22.582 9.284 1.00 91.49 C \\\\nATOM 945 CB LYS A 116 -13.025 21.940 7.064 1.00 91.49 C \\\\nATOM 946 O LYS A 116 -13.315 23.465 9.464 1.00 91.49 O \\\\nATOM 947 CG LYS A 116 -12.402 20.814 6.222 1.00 91.49 C \\\\nATOM 948 CD LYS A 116 -11.661 21.398 5.012 1.00 91.49 C \\\\nATOM 949 CE LYS A 116 -11.126 20.283 4.104 1.00 91.49 C \\\\nATOM 950 NZ LYS A 116 -10.485 20.836 2.882 1.00 91.49 N \\\\nATOM 951 N LYS A 117 -15.291 22.530 9.975 1.00 94.76 N \\\\nATOM 952 CA LYS A 117 -15.671 23.462 11.058 1.00 94.76 C \\\\nATOM 953 C LYS A 117 -14.675 23.438 12.231 1.00 94.76 C \\\\nATOM 954 CB LYS A 117 -17.094 23.133 11.562 1.00 94.76 C \\\\nATOM 955 O LYS A 117 -13.972 22.443 12.419 1.00 94.76 O \\\\nATOM 956 CG LYS A 117 -18.187 23.326 10.495 1.00 94.76 C \\\\nATOM 957 CD LYS A 117 -19.589 23.130 11.097 1.00 94.76 C \\\\nATOM 958 CE LYS A 117 -20.685 23.404 10.057 1.00 94.76 C \\\\nATOM 959 NZ LYS A 117 -22.042 23.260 10.645 1.00 94.76 N \\\\nATOM 960 N ASP A 118 -14.688 24.484 13.060 1.00 95.42 N \\\\nATOM 961 CA ASP A 118 -13.849 24.625 14.270 1.00 95.42 C \\\\nATOM 962 C ASP A 118 -14.050 23.504 15.300 1.00 95.42 C \\\\nATOM 963 CB ASP A 118 -14.163 25.963 14.953 1.00 95.42 C \\\\nATOM 964 O ASP A 118 -13.168 23.209 16.108 1.00 95.42 O \\\\nATOM 965 CG ASP A 118 -13.874 27.158 14.050 1.00 95.42 C \\\\nATOM 966 OD1 ASP A 118 -12.850 27.096 13.335 1.00 95.42 O \\\\nATOM 967 OD2 ASP A 118 -14.713 28.080 14.050 1.00 95.42 O \\\\nATOM 968 N GLU A 119 -15.197 22.831 15.240 1.00 96.27 N \\\\nATOM 969 CA GLU A 119 -15.482 21.617 15.990 1.00 96.27 C \\\\nATOM 970 C GLU A 119 -15.620 20.390 15.078 1.00 96.27 C \\\\nATOM 971 CB GLU A 119 -16.725 21.802 16.862 1.00 96.27 C \\\\nATOM 972 O GLU A 119 -15.860 20.478 13.870 1.00 96.27 O \\\\nATOM 973 CG GLU A 119 -16.575 22.893 17.932 1.00 96.27 C \\\\nATOM 974 CD GLU A 119 -17.483 22.585 19.128 1.00 96.27 C \\\\nATOM 975 OE1 GLU A 119 -16.925 22.384 20.230 1.00 96.27 O \\\\nATOM 976 OE2 GLU A 119 -18.703 22.390 18.922 1.00 96.27 O \\\\nATOM 977 N VAL A 120 -15.467 19.208 15.673 1.00 96.95 N \\\\nATOM 978 CA VAL A 120 -15.663 17.914 15.015 1.00 96.95 C \\\\nATOM 979 C VAL A 120 -16.561 17.015 15.856 1.00 96.95 C \\\\nATOM 980 CB VAL A 120 -14.313 17.253 14.669 1.00 96.95 C \\\\nATOM 981 O VAL A 120 -16.314 16.811 17.046 1.00 96.95 O \\\\nATOM 982 CG1 VAL A 120 -13.321 17.164 15.838 1.00 96.95 C \\\\nATOM 983 CG2 VAL A 120 -14.496 15.836 14.107 1.00 96.95 C \\\\nATOM 984 N CYS A 121 -17.576 16.433 15.216 1.00 97.92 N \\\\nATOM 985 CA CYS A 121 -18.431 15.420 15.813 1.00 97.92 C \\\\nATOM 986 C CYS A 121 -17.659 14.112 16.029 1.00 97.92 C \\\\nATOM 987 CB CYS A 121 -19.679 15.186 14.954 1.00 97.92 C \\\\nATOM 988 O CYS A 121 -17.033 13.574 15.111 1.00 97.92 O \\\\nATOM 989 SG CYS A 121 -20.832 14.159 15.908 1.00 97.92 S \\\\nATOM 990 N VAL A 122 -17.752 13.582 17.243 1.00 97.72 N \\\\nATOM 991 CA VAL A 122 -17.203 12.298 17.686 1.00 97.72 C \\\\nATOM 992 C VAL A 122 -18.285 11.307 18.125 1.00 97.72 C \\\\nATOM 993 CB VAL A 122 -16.141 12.495 18.782 1.00 97.72 C \\\\nATOM 994 O VAL A 122 -17.956 10.257 18.673 1.00 97.72 O \\\\nATOM 995 CG1 VAL A 122 -14.932 13.260 18.234 1.00 97.72 C \\\\nATOM 996 CG2 VAL A 122 -16.642 13.217 20.035 1.00 97.72 C \\\\nATOM 997 N ASN A 123 -19.565 11.613 17.879 1.00 97.71 N \\\\nATOM 998 CA ASN A 123 -20.654 10.650 18.046 1.00 97.71 C \\\\nATOM 999 C ASN A 123 -20.443 9.497 17.044 1.00 97.71 C \\\\nATOM 1000 CB ASN A 123 -22.010 11.357 17.833 1.00 97.71 C \\\\nATOM 1001 O ASN A 123 -20.509 9.739 15.837 1.00 97.71 O \\\\nATOM 1002 CG ASN A 123 -23.206 10.461 18.123 1.00 97.71 C \\\\nATOM 1003 ND2 ASN A 123 -24.356 11.036 18.386 1.00 97.71 N \\\\nATOM 1004 OD1 ASN A 123 -23.101 9.241 18.132 1.00 97.71 O \\\\nATOM 1005 N PRO A 124 -20.192 8.251 17.485 1.00 97.24 N \\\\nATOM 1006 CA PRO A 124 -19.894 7.164 16.560 1.00 97.24 C \\\\nATOM 1007 C PRO A 124 -21.113 6.735 15.729 1.00 97.24 C \\\\nATOM 1008 CB PRO A 124 -19.341 6.042 17.439 1.00 97.24 C \\\\nATOM 1009 O PRO A 124 -20.937 6.063 14.717 1.00 97.24 O \\\\nATOM 1010 CG PRO A 124 -20.066 6.254 18.763 1.00 97.24 C \\\\nATOM 1011 CD PRO A 124 -20.149 7.776 18.862 1.00 97.24 C \\\\nATOM 1012 N TYR A 125 -22.334 7.132 16.107 1.00 97.21 N \\\\nATOM 1013 CA TYR A 125 -23.568 6.894 15.342 1.00 97.21 C \\\\nATOM 1014 C TYR A 125 -23.873 8.001 14.322 1.00 97.21 C \\\\nATOM 1015 CB TYR A 125 -24.731 6.614 16.304 1.00 97.21 C \\\\nATOM 1016 O TYR A 125 -24.833 7.895 13.569 1.00 97.21 O \\\\nATOM 1017 CG TYR A 125 -24.449 5.401 17.166 1.00 97.21 C \\\\nATOM 1018 CD1 TYR A 125 -24.625 4.107 16.637 1.00 97.21 C \\\\nATOM 1019 CD2 TYR A 125 -23.912 5.567 18.455 1.00 97.21 C \\\\nATOM 1020 CE1 TYR A 125 -24.241 2.979 17.387 1.00 97.21 C \\\\nATOM 1021 CE2 TYR A 125 -23.528 4.440 19.204 1.00 97.21 C \\\\nATOM 1022 OH TYR A 125 -23.321 2.060 19.402 1.00 97.21 O \\\\nATOM 1023 CZ TYR A 125 -23.690 3.144 18.673 1.00 97.21 C \\\\nATOM 1024 N HIS A 126 -23.027 9.035 14.238 1.00 97.82 N \\\\nATOM 1025 CA HIS A 126 -23.063 10.054 13.176 1.00 97.82 C \\\\nATOM 1026 C HIS A 126 -22.159 9.726 11.984 1.00 97.82 C \\\\nATOM 1027 CB HIS A 126 -22.751 11.426 13.780 1.00 97.82 C \\\\nATOM 1028 O HIS A 126 -21.988 10.547 11.084 1.00 97.82 O \\\\nATOM 1029 CG HIS A 126 -23.879 12.016 14.583 1.00 97.82 C \\\\nATOM 1030 CD2 HIS A 126 -25.075 11.415 14.857 1.00 97.82 C \\\\nATOM 1031 ND1 HIS A 126 -23.925 13.346 15.007 1.00 97.82 N \\\\nATOM 1032 CE1 HIS A 126 -25.172 13.518 15.476 1.00 97.82 C \\\\nATOM 1033 NE2 HIS A 126 -25.864 12.375 15.425 1.00 97.82 N \\\\nATOM 1034 N TYR A 127 -21.611 8.513 11.960 1.00 97.31 N \\\\nATOM 1035 CA TYR A 127 -20.844 7.963 10.852 1.00 97.31 C \\\\nATOM 1036 C TYR A 127 -21.405 6.582 10.486 1.00 97.31 C \\\\nATOM 1037 CB TYR A 127 -19.353 7.915 11.234 1.00 97.31 C \\\\nATOM 1038 O TYR A 127 -21.826 5.831 11.364 1.00 97.31 O \\\\nATOM 1039 CG TYR A 127 -18.749 9.275 11.566 1.00 97.31 C \\\\nATOM 1040 CD1 TYR A 127 -18.178 10.061 10.546 1.00 97.31 C \\\\nATOM 1041 CD2 TYR A 127 -18.801 9.777 12.883 1.00 97.31 C \\\\nATOM 1042 CE1 TYR A 127 -17.676 11.346 10.836 1.00 97.31 C \\\\nATOM 1043 CE2 TYR A 127 -18.315 11.068 13.176 1.00 97.31 C \\\\nATOM 1044 OH TYR A 127 -17.256 13.099 12.420 1.00 97.31 O \\\\nATOM 1045 CZ TYR A 127 -17.754 11.859 12.148 1.00 97.31 C \\\\nATOM 1046 N GLN A 128 -21.398 6.218 9.210 1.00 94.94 N \\\\nATOM 1047 CA GLN A 128 -21.660 4.866 8.717 1.00 94.94 C \\\\nATOM 1048 C GLN A 128 -20.363 4.307 8.128 1.00 94.94 C \\\\nATOM 1049 CB GLN A 128 -22.818 4.891 7.707 1.00 94.94 C \\\\nATOM 1050 O GLN A 128 -19.571 5.061 7.559 1.00 94.94 O \\\\nATOM 1051 CG GLN A 128 -23.315 3.479 7.337 1.00 94.94 C \\\\nATOM 1052 CD GLN A 128 -24.500 3.481 6.375 1.00 94.94 C \\\\nATOM 1053 NE2 GLN A 128 -24.954 2.326 5.934 1.00 94.94 N \\\\nATOM 1054 OE1 GLN A 128 -25.037 4.517 6.017 1.00 94.94 O \\\\nATOM 1055 N ARG A 129 -20.128 2.999 8.271 1.00 93.24 N \\\\nATOM 1056 CA ARG A 129 -19.017 2.345 7.577 1.00 93.24 C \\\\nATOM 1057 C ARG A 129 -19.354 2.248 6.093 1.00 93.24 C \\\\nATOM 1058 CB ARG A 129 -18.701 0.979 8.201 1.00 93.24 C \\\\nATOM 1059 O ARG A 129 -20.494 1.964 5.745 1.00 93.24 O \\\\nATOM 1060 CG ARG A 129 -17.357 0.430 7.701 1.00 93.24 C \\\\nATOM 1061 CD ARG A 129 -17.001 -0.874 8.416 1.00 93.24 C \\\\nATOM 1062 NE ARG A 129 -15.580 -1.217 8.225 1.00 93.24 N \\\\nATOM 1063 NH1 ARG A 129 -15.545 -3.069 9.565 1.00 93.24 N \\\\nATOM 1064 NH2 ARG A 129 -13.654 -2.316 8.685 1.00 93.24 N \\\\nATOM 1065 CZ ARG A 129 -14.937 -2.199 8.816 1.00 93.24 C \\\\nATOM 1066 N VAL A 130 -18.379 2.493 5.228 1.00 90.59 N \\\\nATOM 1067 CA VAL A 130 -18.525 2.254 3.792 1.00 90.59 C \\\\nATOM 1068 C VAL A 130 -18.584 0.743 3.573 1.00 90.59 C \\\\nATOM 1069 CB VAL A 130 -17.388 2.919 2.995 1.00 90.59 C \\\\nATOM 1070 O VAL A 130 -17.615 0.034 3.834 1.00 90.59 O \\\\nATOM 1071 CG1 VAL A 130 -17.556 2.671 1.492 1.00 90.59 C \\\\nATOM 1072 CG2 VAL A 130 -17.383 4.441 3.214 1.00 90.59 C \\\\nATOM 1073 N GLU A 131 -19.744 0.256 3.146 1.00 83.73 N \\\\nATOM 1074 CA GLU A 131 -19.983 -1.153 2.835 1.00 83.73 C \\\\nATOM 1075 C GLU A 131 -19.492 -1.473 1.415 1.00 83.73 C \\\\nATOM 1076 CB GLU A 131 -21.480 -1.470 3.027 1.00 83.73 C \\\\nATOM 1077 O GLU A 131 -19.639 -0.659 0.501 1.00 83.73 O \\\\nATOM 1078 CG GLU A 131 -21.875 -1.449 4.519 1.00 83.73 C \\\\nATOM 1079 CD GLU A 131 -23.394 -1.409 4.770 1.00 83.73 C \\\\nATOM 1080 OE1 GLU A 131 -23.785 -0.811 5.806 1.00 83.73 O \\\\nATOM 1081 OE2 GLU A 131 -24.150 -1.953 3.938 1.00 83.73 O \\\\nATOM 1082 N THR A 132 -18.902 -2.655 1.219 1.00 81.31 N \\\\nATOM 1083 CA THR A 132 -18.564 -3.156 -0.121 1.00 81.31 C \\\\nATOM 1084 C THR A 132 -19.844 -3.639 -0.803 1.00 81.31 C \\\\nATOM 1085 CB THR A 132 -17.508 -4.271 -0.069 1.00 81.31 C \\\\nATOM 1086 O THR A 132 -20.510 -4.522 -0.257 1.00 81.31 O \\\\nATOM 1087 CG2 THR A 132 -17.101 -4.782 -1.451 1.00 81.31 C \\\\nATOM 1088 OG1 THR A 132 -16.328 -3.776 0.523 1.00 81.31 O \\\\nATOM 1089 N PRO A 133 -20.218 -3.090 -1.974 1.00 82.14 N \\\\nATOM 1090 CA PRO A 133 -21.417 -3.512 -2.676 1.00 82.14 C \\\\nATOM 1091 C PRO A 133 -21.256 -4.949 -3.177 1.00 82.14 C \\\\nATOM 1092 CB PRO A 133 -21.596 -2.513 -3.821 1.00 82.14 C \\\\nATOM 1093 O PRO A 133 -20.198 -5.332 -3.680 1.00 82.14 O \\\\nATOM 1094 CG PRO A 133 -20.167 -2.064 -4.130 1.00 82.14 C \\\\nATOM 1095 CD PRO A 133 -19.492 -2.105 -2.762 1.00 82.14 C \\\\nATOM 1096 N VAL A 134 -22.324 -5.742 -3.076 1.00 84.73 N \\\\nATOM 1097 CA VAL A 134 -22.350 -7.095 -3.640 1.00 84.73 C \\\\nATOM 1098 C VAL A 134 -22.305 -6.989 -5.163 1.00 84.73 C \\\\nATOM 1099 CB VAL A 134 -23.578 -7.896 -3.166 1.00 84.73 C \\\\nATOM 1100 O VAL A 134 -23.174 -6.370 -5.777 1.00 84.73 O \\\\nATOM 1101 CG1 VAL A 134 -23.554 -9.328 -3.718 1.00 84.73 C \\\\nATOM 1102 CG2 VAL A 134 -23.620 -7.990 -1.634 1.00 84.73 C \\\\nATOM 1103 N LEU A 135 -21.278 -7.581 -5.769 1.00 89.09 N \\\\nATOM 1104 CA LEU A 135 -21.108 -7.609 -7.219 1.00 89.09 C \\\\nATOM 1105 C LEU A 135 -21.987 -8.724 -7.819 1.00 89.09 C \\\\nATOM 1106 CB LEU A 135 -19.617 -7.789 -7.561 1.00 89.09 C \\\\nATOM 1107 O LEU A 135 -21.986 -9.837 -7.283 1.00 89.09 O \\\\nATOM 1108 CG LEU A 135 -18.693 -6.691 -6.997 1.00 89.09 C \\\\nATOM 1109 CD1 LEU A 135 -17.229 -7.061 -7.208 1.00 89.09 C \\\\nATOM 1110 CD2 LEU A 135 -18.944 -5.332 -7.652 1.00 89.09 C \\\\nATOM 1111 N PRO A 136 -22.738 -8.465 -8.907 1.00 88.64 N \\\\nATOM 1112 CA PRO A 136 -23.542 -9.495 -9.559 1.00 88.64 C \\\\nATOM 1113 C PRO A 136 -22.634 -10.566 -10.189 1.00 88.64 C \\\\nATOM 1114 CB PRO A 136 -24.372 -8.757 -10.614 1.00 88.64 C \\\\nATOM 1115 O PRO A 136 -21.542 -10.229 -10.650 1.00 88.64 O \\\\nATOM 1116 CG PRO A 136 -23.484 -7.567 -10.984 1.00 88.64 C \\\\nATOM 1117 CD PRO A 136 -22.802 -7.219 -9.660 1.00 88.64 C \\\\nATOM 1118 N PRO A 137 -23.050 -11.845 -10.241 1.00 90.23 N \\\\nATOM 1119 CA PRO A 137 -22.293 -12.873 -10.945 1.00 90.23 C \\\\nATOM 1120 C PRO A 137 -22.248 -12.582 -12.449 1.00 90.23 C \\\\nATOM 1121 CB PRO A 137 -23.010 -14.193 -10.650 1.00 90.23 C \\\\nATOM 1122 O PRO A 137 -23.247 -12.178 -13.044 1.00 90.23 O \\\\nATOM 1123 CG PRO A 137 -24.458 -13.757 -10.418 1.00 90.23 C \\\\nATOM 1124 CD PRO A 137 -24.311 -12.385 -9.756 1.00 90.23 C \\\\nATOM 1125 N VAL A 138 -21.102 -12.848 -13.072 1.00 90.43 N \\\\nATOM 1126 CA VAL A 138 -20.956 -12.812 -14.533 1.00 90.43 C \\\\nATOM 1127 C VAL A 138 -21.520 -14.113 -15.097 1.00 90.43 C \\\\nATOM 1128 CB VAL A 138 -19.483 -12.596 -14.923 1.00 90.43 C \\\\nATOM 1129 O VAL A 138 -21.149 -15.188 -14.634 1.00 90.43 O \\\\nATOM 1130 CG1 VAL A 138 -19.244 -12.761 -16.426 1.00 90.43 C \\\\nATOM 1131 CG2 VAL A 138 -19.033 -11.184 -14.531 1.00 90.43 C \\\\nATOM 1132 N LEU A 139 -22.432 -14.030 -16.064 1.00 90.13 N \\\\nATOM 1133 CA LEU A 139 -23.028 -15.201 -16.710 1.00 90.13 C \\\\nATOM 1134 C LEU A 139 -22.212 -15.571 -17.950 1.00 90.13 C \\\\nATOM 1135 CB LEU A 139 -24.497 -14.911 -17.070 1.00 90.13 C \\\\nATOM 1136 O LEU A 139 -22.111 -14.764 -18.870 1.00 90.13 O \\\\nATOM 1137 CG LEU A 139 -25.419 -14.571 -15.886 1.00 90.13 C \\\\nATOM 1138 CD1 LEU A 139 -26.852 -14.393 -16.388 1.00 90.13 C \\\\nATOM 1139 CD2 LEU A 139 -25.424 -15.658 -14.809 1.00 90.13 C \\\\nATOM 1140 N VAL A 140 -21.646 -16.777 -17.976 1.00 86.83 N \\\\nATOM 1141 CA VAL A 140 -20.816 -17.263 -19.086 1.00 86.83 C \\\\nATOM 1142 C VAL A 140 -21.594 -18.289 -19.916 1.00 86.83 C \\\\nATOM 1143 CB VAL A 140 -19.483 -17.841 -18.578 1.00 86.83 C \\\\nATOM 1144 O VAL A 140 -22.031 -19.297 -19.353 1.00 86.83 O \\\\nATOM 1145 CG1 VAL A 140 -18.603 -18.256 -19.760 1.00 86.83 C \\\\nATOM 1146 CG2 VAL A 140 -18.706 -16.789 -17.774 1.00 86.83 C \\\\nATOM 1147 N PRO A 141 -21.784 -18.080 -21.233 1.00 80.27 N \\\\nATOM 1148 CA PRO A 141 -22.358 -19.094 -22.111 1.00 80.27 C \\\\nATOM 1149 C PRO A 141 -21.443 -20.313 -22.197 1.00 80.27 C \\\\nATOM 1150 CB PRO A 141 -22.534 -18.428 -23.485 1.00 80.27 C \\\\nATOM 1151 O PRO A 141 -20.263 -20.186 -22.524 1.00 80.27 O \\\\nATOM 1152 CG PRO A 141 -22.470 -16.930 -23.190 1.00 80.27 C \\\\nATOM 1153 CD PRO A 141 -21.543 -16.855 -21.981 1.00 80.27 C \\\\nATOM 1154 N ARG A 142 -21.981 -21.514 -21.970 1.00 69.52 N \\\\nATOM 1155 CA ARG A 142 -21.269 -22.736 -22.351 1.00 69.52 C \\\\nATOM 1156 C ARG A 142 -21.185 -22.821 -23.872 1.00 69.52 C \\\\nATOM 1157 CB ARG A 142 -21.953 -23.967 -21.748 1.00 69.52 C \\\\nATOM 1158 O ARG A 142 -22.206 -22.891 -24.551 1.00 69.52 O \\\\nATOM 1159 CG ARG A 142 -21.631 -24.061 -20.254 1.00 69.52 C \\\\nATOM 1160 CD ARG A 142 -22.346 -25.257 -19.638 1.00 69.52 C \\\\nATOM 1161 NE ARG A 142 -21.928 -25.454 -18.243 1.00 69.52 N \\\\nATOM 1162 NH1 ARG A 142 -23.569 -26.951 -17.623 1.00 69.52 N \\\\nATOM 1163 NH2 ARG A 142 -21.996 -26.344 -16.175 1.00 69.52 N \\\\nATOM 1164 CZ ARG A 142 -22.504 -26.251 -17.367 1.00 69.52 C \\\\nATOM 1165 N HIS A 143 -19.965 -22.851 -24.403 1.00 60.13 N \\\\nATOM 1166 CA HIS A 143 -19.725 -23.115 -25.818 1.00 60.13 C \\\\nATOM 1167 C HIS A 143 -20.074 -24.569 -26.163 1.00 60.13 C \\\\nATOM 1168 CB HIS A 143 -18.268 -22.792 -26.187 1.00 60.13 C \\\\nATOM 1169 O HIS A 143 -19.233 -25.460 -26.058 1.00 60.13 O \\\\nATOM 1170 CG HIS A 143 -17.987 -21.319 -26.313 1.00 60.13 C \\\\nATOM 1171 CD2 HIS A 143 -17.154 -20.573 -25.523 1.00 60.13 C \\\\nATOM 1172 ND1 HIS A 143 -18.492 -20.479 -27.280 1.00 60.13 N \\\\nATOM 1173 CE1 HIS A 143 -17.978 -19.255 -27.072 1.00 60.13 C \\\\nATOM 1174 NE2 HIS A 143 -17.155 -19.264 -26.014 1.00 60.13 N \\\\nATOM 1175 N THR A 144 -21.307 -24.802 -26.609 1.00 49.08 N \\\\nATOM 1176 CA THR A 144 -21.659 -25.991 -27.399 1.00 49.08 C \\\\nATOM 1177 C THR A 144 -21.462 -25.753 -28.894 1.00 49.08 C \\\\nATOM 1178 CB THR A 144 -23.084 -26.500 -27.108 1.00 49.08 C \\\\nATOM 1179 O THR A 144 -20.954 -26.644 -29.567 1.00 49.08 O \\\\nATOM 1180 CG2 THR A 144 -23.051 -27.644 -26.096 1.00 49.08 C \\\\nATOM 1181 OG1 THR A 144 -23.908 -25.493 -26.561 1.00 49.08 O \\\\nATOM 1182 N GLU A 145 -21.785 -24.563 -29.417 1.00 43.90 N \\\\nATOM 1183 CA GLU A 145 -21.641 -24.222 -30.844 1.00 43.90 C \\\\nATOM 1184 C GLU A 145 -21.170 -22.762 -31.027 1.00 43.90 C \\\\nATOM 1185 CB GLU A 145 -22.952 -24.520 -31.606 1.00 43.90 C \\\\nATOM 1186 O GLU A 145 -21.480 -21.888 -30.216 1.00 43.90 O \\\\nATOM 1187 CG GLU A 145 -23.310 -26.023 -31.560 1.00 43.90 C \\\\nATOM 1188 CD GLU A 145 -24.548 -26.438 -32.366 1.00 43.90 C \\\\nATOM 1189 OE1 GLU A 145 -24.808 -27.663 -32.400 1.00 43.90 O \\\\nATOM 1190 OE2 GLU A 145 -25.231 -25.551 -32.922 1.00 43.90 O \\\\nATOM 1191 N ILE A 146 -20.371 -22.501 -32.070 1.00 47.79 N \\\\nATOM 1192 CA ILE A 146 -19.771 -21.185 -32.364 1.00 47.79 C \\\\nATOM 1193 C ILE A 146 -20.657 -20.445 -33.383 1.00 47.79 C \\\\nATOM 1194 CB ILE A 146 -18.323 -21.349 -32.905 1.00 47.79 C \\\\nATOM 1195 O ILE A 146 -20.850 -20.977 -34.478 1.00 47.79 O \\\\nATOM 1196 CG1 ILE A 146 -17.401 -22.045 -31.874 1.00 47.79 C \\\\nATOM 1197 CG2 ILE A 146 -17.724 -19.987 -33.308 1.00 47.79 C \\\\nATOM 1198 CD1 ILE A 146 -16.042 -22.481 -32.443 1.00 47.79 C \\\\nATOM 1199 N PRO A 147 -21.147 -19.220 -33.102 1.00 49.95 N \\\\nATOM 1200 CA PRO A 147 -21.773 -18.379 -34.121 1.00 49.95 C \\\\nATOM 1201 C PRO A 147 -20.759 -18.029 -35.219 1.00 49.95 C \\\\nATOM 1202 CB PRO A 147 -22.294 -17.133 -33.392 1.00 49.95 C \\\\nATOM 1203 O PRO A 147 -19.681 -17.514 -34.929 1.00 49.95 O \\\\nATOM 1204 CG PRO A 147 -22.374 -17.575 -31.931 1.00 49.95 C \\\\nATOM 1205 CD PRO A 147 -21.217 -18.565 -31.807 1.00 49.95 C \\\\nATOM 1206 N ALA A 148 -21.093 -18.327 -36.476 1.00 50.53 N \\\\nATOM 1207 CA ALA A 148 -20.153 -18.237 -37.599 1.00 50.53 C \\\\nATOM 1208 C ALA A 148 -19.879 -16.803 -38.099 1.00 50.53 C \\\\nATOM 1209 CB ALA A 148 -20.670 -19.141 -38.724 1.00 50.53 C \\\\nATOM 1210 O ALA A 148 -18.933 -16.601 -38.856 1.00 50.53 O \\\\nATOM 1211 N GLU A 149 -20.677 -15.819 -37.678 1.00 41.11 N \\\\nATOM 1212 CA GLU A 149 -20.536 -14.413 -38.062 1.00 41.11 C \\\\nATOM 1213 C GLU A 149 -20.661 -13.519 -36.822 1.00 41.11 C \\\\nATOM 1214 CB GLU A 149 -21.581 -14.032 -39.128 1.00 41.11 C \\\\nATOM 1215 O GLU A 149 -21.689 -13.507 -36.145 1.00 41.11 O \\\\nATOM 1216 CG GLU A 149 -21.326 -14.731 -40.475 1.00 41.11 C \\\\nATOM 1217 CD GLU A 149 -22.336 -14.338 -41.566 1.00 41.11 C \\\\nATOM 1218 OE1 GLU A 149 -21.917 -14.275 -42.745 1.00 41.11 O \\\\nATOM 1219 OE2 GLU A 149 -23.526 -14.141 -41.230 1.00 41.11 O \\\\nATOM 1220 N PHE A 150 -19.607 -12.752 -36.542 1.00 50.90 N \\\\nATOM 1221 CA PHE A 150 -19.629 -11.622 -35.614 1.00 50.90 C \\\\nATOM 1222 C PHE A 150 -19.395 -10.328 -36.409 1.00 50.90 C \\\\nATOM 1223 CB PHE A 150 -18.581 -11.808 -34.505 1.00 50.90 C \\\\nATOM 1224 O PHE A 150 -18.740 -10.377 -37.456 1.00 50.90 O \\\\nATOM 1225 CG PHE A 150 -18.997 -12.783 -33.417 1.00 50.90 C \\\\nATOM 1226 CD1 PHE A 150 -19.693 -12.318 -32.284 1.00 50.90 C \\\\nATOM 1227 CD2 PHE A 150 -18.701 -14.154 -33.536 1.00 50.90 C \\\\nATOM 1228 CE1 PHE A 150 -20.083 -13.215 -31.273 1.00 50.90 C \\\\nATOM 1229 CE2 PHE A 150 -19.093 -15.053 -32.528 1.00 50.90 C \\\\nATOM 1230 CZ PHE A 150 -19.783 -14.584 -31.395 1.00 50.90 C \\\\nATOM 1231 N PRO A 151 -19.893 -9.167 -35.939 1.00 45.48 N \\\\nATOM 1232 CA PRO A 151 -19.538 -7.879 -36.527 1.00 45.48 C \\\\nATOM 1233 C PRO A 151 -18.012 -7.690 -36.531 1.00 45.48 C \\\\nATOM 1234 CB PRO A 151 -20.222 -6.811 -35.664 1.00 45.48 C \\\\nATOM 1235 O PRO A 151 -17.342 -8.232 -35.645 1.00 45.48 O \\\\nATOM 1236 CG PRO A 151 -21.324 -7.575 -34.931 1.00 45.48 C \\\\nATOM 1237 CD PRO A 151 -20.732 -8.972 -34.769 1.00 45.48 C \\\\nATOM 1238 N PRO A 152 -17.448 -6.916 -37.477 1.00 43.35 N \\\\nATOM 1239 CA PRO A 152 -16.029 -6.596 -37.439 1.00 43.35 C \\\\nATOM 1240 C PRO A 152 -15.691 -5.935 -36.098 1.00 43.35 C \\\\nATOM 1241 CB PRO A 152 -15.767 -5.682 -38.642 1.00 43.35 C \\\\nATOM 1242 O PRO A 152 -16.322 -4.956 -35.703 1.00 43.35 O \\\\nATOM 1243 CG PRO A 152 -17.138 -5.077 -38.950 1.00 43.35 C \\\\nATOM 1244 CD PRO A 152 -18.120 -6.171 -38.530 1.00 43.35 C \\\\nATOM 1245 N LEU A 153 -14.708 -6.500 -35.396 1.00 46.99 N \\\\nATOM 1246 CA LEU A 153 -14.107 -5.858 -34.233 1.00 46.99 C \\\\nATOM 1247 C LEU A 153 -13.436 -4.565 -34.703 1.00 46.99 C \\\\nATOM 1248 CB LEU A 153 -13.072 -6.804 -33.587 1.00 46.99 C \\\\nATOM 1249 O LEU A 153 -12.665 -4.599 -35.664 1.00 46.99 O \\\\nATOM 1250 CG LEU A 153 -13.670 -8.031 -32.874 1.00 46.99 C \\\\nATOM 1251 CD1 LEU A 153 -12.566 -9.043 -32.557 1.00 46.99 C \\\\nATOM 1252 CD2 LEU A 153 -14.346 -7.649 -31.554 1.00 46.99 C \\\\nATOM 1253 N ASP A 154 -13.695 -3.453 -34.013 1.00 44.28 N \\\\nATOM 1254 CA ASP A 154 -12.870 -2.256 -34.164 1.00 44.28 C \\\\nATOM 1255 C ASP A 154 -11.413 -2.634 -33.881 1.00 44.28 C \\\\nATOM 1256 CB ASP A 154 -13.326 -1.135 -33.215 1.00 44.28 C \\\\nATOM 1257 O ASP A 154 -11.113 -3.281 -32.870 1.00 44.28 O \\\\nATOM 1258 CG ASP A 154 -14.562 -0.385 -33.716 1.00 44.28 C \\\\nATOM 1259 OD1 ASP A 154 -14.599 -0.065 -34.926 1.00 44.28 O \\\\nATOM 1260 OD2 ASP A 154 -15.441 -0.101 -32.871 1.00 44.28 O \\\\nATOM 1261 N ASP A 155 -10.504 -2.262 -34.786 1.00 39.25 N \\\\nATOM 1262 CA ASP A 155 -9.109 -2.671 -34.676 1.00 39.25 C \\\\nATOM 1263 C ASP A 155 -8.376 -1.873 -33.589 1.00 39.25 C \\\\nATOM 1264 CB ASP A 155 -8.374 -2.672 -36.023 1.00 39.25 C \\\\nATOM 1265 O ASP A 155 -7.690 -0.873 -33.821 1.00 39.25 O \\\\nATOM 1266 CG ASP A 155 -6.969 -3.266 -35.845 1.00 39.25 C \\\\nATOM 1267 OD1 ASP A 155 -6.731 -3.949 -34.821 1.00 39.25 O \\\\nATOM 1268 OD2 ASP A 155 -6.084 -3.012 -36.687 1.00 39.25 O \\\\nATOM 1269 N TYR A 156 -8.500 -2.367 -32.362 1.00 43.30 N \\\\nATOM 1270 CA TYR A 156 -7.770 -1.886 -31.202 1.00 43.30 C \\\\nATOM 1271 C TYR A 156 -6.262 -2.222 -31.252 1.00 43.30 C \\\\nATOM 1272 CB TYR A 156 -8.485 -2.362 -29.921 1.00 43.30 C \\\\nATOM 1273 O TYR A 156 -5.565 -1.899 -30.285 1.00 43.30 O \\\\nATOM 1274 CG TYR A 156 -9.726 -1.555 -29.566 1.00 43.30 C \\\\nATOM 1275 CD1 TYR A 156 -9.599 -0.300 -28.937 1.00 43.30 C \\\\nATOM 1276 CD2 TYR A 156 -11.012 -2.049 -29.857 1.00 43.30 C \\\\nATOM 1277 CE1 TYR A 156 -10.733 0.470 -28.621 1.00 43.30 C \\\\nATOM 1278 CE2 TYR A 156 -12.154 -1.294 -29.526 1.00 43.30 C \\\\nATOM 1279 OH TYR A 156 -13.120 0.694 -28.593 1.00 43.30 O \\\\nATOM 1280 CZ TYR A 156 -12.018 -0.032 -28.914 1.00 43.30 C \\\\nATOM 1281 N SER A 157 -5.703 -2.776 -32.343 1.00 44.03 N \\\\nATOM 1282 CA SER A 157 -4.243 -2.892 -32.529 1.00 44.03 C \\\\nATOM 1283 C SER A 157 -3.537 -1.535 -32.392 1.00 44.03 C \\\\nATOM 1284 CB SER A 157 -3.889 -3.535 -33.881 1.00 44.03 C \\\\nATOM 1285 O SER A 157 -2.504 -1.435 -31.732 1.00 44.03 O \\\\nATOM 1286 OG SER A 157 -4.039 -2.628 -34.955 1.00 44.03 O \\\\nATOM 1287 N HIS A 158 -4.160 -0.458 -32.880 1.00 38.34 N \\\\nATOM 1288 CA HIS A 158 -3.667 0.916 -32.739 1.00 38.34 C \\\\nATOM 1289 C HIS A 158 -3.891 1.533 -31.347 1.00 38.34 C \\\\nATOM 1290 CB HIS A 158 -4.280 1.774 -33.850 1.00 38.34 C \\\\nATOM 1291 O HIS A 158 -3.365 2.606 -31.059 1.00 38.34 O \\\\nATOM 1292 CG HIS A 158 -3.831 1.351 -35.226 1.00 38.34 C \\\\nATOM 1293 CD2 HIS A 158 -4.630 1.066 -36.301 1.00 38.34 C \\\\nATOM 1294 ND1 HIS A 158 -2.527 1.162 -35.629 1.00 38.34 N \\\\nATOM 1295 CE1 HIS A 158 -2.543 0.778 -36.915 1.00 38.34 C \\\\nATOM 1296 NE2 HIS A 158 -3.798 0.739 -37.379 1.00 38.34 N \\\\nATOM 1297 N SER A 159 -4.625 0.858 -30.456 1.00 38.83 N \\\\nATOM 1298 CA SER A 159 -4.744 1.260 -29.046 1.00 38.83 C \\\\nATOM 1299 C SER A 159 -3.651 0.669 -28.154 1.00 38.83 C \\\\nATOM 1300 CB SER A 159 -6.123 0.917 -28.499 1.00 38.83 C \\\\nATOM 1301 O SER A 159 -3.557 1.043 -26.982 1.00 38.83 O \\\\nATOM 1302 OG SER A 159 -6.218 -0.454 -28.156 1.00 38.83 O \\\\nATOM 1303 N ILE A 160 -2.822 -0.242 -28.689 1.00 40.21 N \\\\nATOM 1304 CA ILE A 160 -1.624 -0.744 -28.015 1.00 40.21 C \\\\nATOM 1305 C ILE A 160 -0.648 0.430 -27.888 1.00 40.21 C \\\\nATOM 1306 CB ILE A 160 -0.969 -1.918 -28.780 1.00 40.21 C \\\\nATOM 1307 O ILE A 160 -0.074 0.861 -28.888 1.00 40.21 O \\\\nATOM 1308 CG1 ILE A 160 -1.959 -3.092 -28.956 1.00 40.21 C \\\\nATOM 1309 CG2 ILE A 160 0.289 -2.393 -28.019 1.00 40.21 C \\\\nATOM 1310 CD1 ILE A 160 -1.440 -4.208 -29.872 1.00 40.21 C \\\\nATOM 1311 N PRO A 161 -0.412 0.962 -26.681 1.00 43.58 N \\\\nATOM 1312 CA PRO A 161 0.552 2.023 -26.524 1.00 43.58 C \\\\nATOM 1313 C PRO A 161 1.932 1.384 -26.370 1.00 43.58 C \\\\nATOM 1314 CB PRO A 161 0.068 2.791 -25.297 1.00 43.58 C \\\\nATOM 1315 O PRO A 161 2.152 0.600 -25.449 1.00 43.58 O \\\\nATOM 1316 CG PRO A 161 -0.750 1.782 -24.475 1.00 43.58 C \\\\nATOM 1317 CD PRO A 161 -0.924 0.562 -25.378 1.00 43.58 C \\\\nATOM 1318 N GLU A 162 2.907 1.787 -27.186 1.00 51.97 N \\\\nATOM 1319 CA GLU A 162 4.313 1.330 -27.096 1.00 51.97 C \\\\nATOM 1320 C GLU A 162 4.959 1.568 -25.708 1.00 51.97 C \\\\nATOM 1321 CB GLU A 162 5.148 2.041 -28.171 1.00 51.97 C \\\\nATOM 1322 O GLU A 162 6.053 1.091 -25.403 1.00 51.97 O \\\\nATOM 1323 CG GLU A 162 4.705 1.733 -29.611 1.00 51.97 C \\\\nATOM 1324 CD GLU A 162 5.627 2.428 -30.624 1.00 51.97 C \\\\nATOM 1325 OE1 GLU A 162 6.049 1.755 -31.589 1.00 51.97 O \\\\nATOM 1326 OE2 GLU A 162 5.927 3.624 -30.395 1.00 51.97 O \\\\nATOM 1327 N ASN A 163 4.263 2.268 -24.805 1.00 55.17 N \\\\nATOM 1328 CA ASN A 163 4.623 2.384 -23.398 1.00 55.17 C \\\\nATOM 1329 C ASN A 163 4.496 1.090 -22.566 1.00 55.17 C \\\\nATOM 1330 CB ASN A 163 3.936 3.622 -22.785 1.00 55.17 C \\\\nATOM 1331 O ASN A 163 4.902 1.119 -21.402 1.00 55.17 O \\\\nATOM 1332 CG ASN A 163 2.443 3.565 -22.528 1.00 55.17 C \\\\nATOM 1333 ND2 ASN A 163 1.793 4.704 -22.602 1.00 55.17 N \\\\nATOM 1334 OD1 ASN A 163 1.852 2.571 -22.154 1.00 55.17 O \\\\nATOM 1335 N THR A 164 4.011 -0.025 -23.135 1.00 50.75 N \\\\nATOM 1336 CA THR A 164 3.756 -1.293 -22.421 1.00 50.75 C \\\\nATOM 1337 C THR A 164 4.792 -2.411 -22.609 1.00 50.75 C \\\\nATOM 1338 CB THR A 164 2.345 -1.846 -22.708 1.00 50.75 C \\\\nATOM 1339 O THR A 164 4.489 -3.547 -22.245 1.00 50.75 O \\\\nATOM 1340 CG2 THR A 164 1.248 -0.843 -22.368 1.00 50.75 C \\\\nATOM 1341 OG1 THR A 164 2.175 -2.204 -24.057 1.00 50.75 O \\\\nATOM 1342 N ASN A 165 5.985 -2.158 -23.162 1.00 46.01 N \\\\nATOM 1343 CA ASN A 165 6.958 -3.231 -23.437 1.00 46.01 C \\\\nATOM 1344 C ASN A 165 7.416 -3.989 -22.172 1.00 46.01 C \\\\nATOM 1345 CB ASN A 165 8.159 -2.701 -24.250 1.00 46.01 C \\\\nATOM 1346 O ASN A 165 8.296 -3.539 -21.434 1.00 46.01 O \\\\nATOM 1347 CG ASN A 165 7.840 -2.535 -25.727 1.00 46.01 C \\\\nATOM 1348 ND2 ASN A 165 8.836 -2.447 -26.576 1.00 46.01 N \\\\nATOM 1349 OD1 ASN A 165 6.696 -2.500 -26.135 1.00 46.01 O \\\\nATOM 1350 N PHE A 166 6.859 -5.189 -21.983 1.00 39.23 N \\\\nATOM 1351 CA PHE A 166 7.439 -6.247 -21.160 1.00 39.23 C \\\\nATOM 1352 C PHE A 166 8.686 -6.815 -21.859 1.00 39.23 C \\\\nATOM 1353 CB PHE A 166 6.422 -7.383 -20.959 1.00 39.23 C \\\\nATOM 1354 O PHE A 166 8.648 -7.028 -23.072 1.00 39.23 O \\\\nATOM 1355 CG PHE A 166 5.298 -7.094 -19.983 1.00 39.23 C \\\\nATOM 1356 CD1 PHE A 166 5.477 -7.366 -18.612 1.00 39.23 C \\\\nATOM 1357 CD2 PHE A 166 4.061 -6.601 -20.440 1.00 39.23 C \\\\nATOM 1358 CE1 PHE A 166 4.427 -7.142 -17.704 1.00 39.23 C \\\\nATOM 1359 CE2 PHE A 166 3.004 -6.398 -19.533 1.00 39.23 C \\\\nATOM 1360 CZ PHE A 166 3.188 -6.666 -18.165 1.00 39.23 C \\\\nATOM 1361 N PRO A 167 9.773 -7.129 -21.133 1.00 38.71 N \\\\nATOM 1362 CA PRO A 167 10.925 -7.804 -21.715 1.00 38.71 C \\\\nATOM 1363 C PRO A 167 10.655 -9.311 -21.872 1.00 38.71 C \\\\nATOM 1364 CB PRO A 167 12.089 -7.465 -20.778 1.00 38.71 C \\\\nATOM 1365 O PRO A 167 11.086 -10.120 -21.052 1.00 38.71 O \\\\nATOM 1366 CG PRO A 167 11.413 -7.359 -19.411 1.00 38.71 C \\\\nATOM 1367 CD PRO A 167 10.026 -6.799 -19.738 1.00 38.71 C \\\\nATOM 1368 N ALA A 168 9.985 -9.694 -22.961 1.00 35.78 N \\\\nATOM 1369 CA ALA A 168 10.348 -10.935 -23.644 1.00 35.78 C \\\\nATOM 1370 C ALA A 168 11.684 -10.665 -24.361 1.00 35.78 C \\\\nATOM 1371 CB ALA A 168 9.221 -11.358 -24.591 1.00 35.78 C \\\\nATOM 1372 O ALA A 168 11.835 -9.631 -25.011 1.00 35.78 O \\\\nATOM 1373 N GLY A 169 12.697 -11.498 -24.123 1.00 29.87 N \\\\nATOM 1374 CA GLY A 169 14.087 -11.107 -24.379 1.00 29.87 C \\\\nATOM 1375 C GLY A 169 14.470 -11.009 -25.859 1.00 29.87 C \\\\nATOM 1376 O GLY A 169 14.032 -11.835 -26.648 1.00 29.87 O \\\\nATOM 1377 N ILE A 170 15.332 -10.035 -26.181 1.00 36.65 N \\\\nATOM 1378 CA ILE A 170 16.510 -10.086 -27.078 1.00 36.65 C \\\\nATOM 1379 C ILE A 170 17.256 -8.728 -26.959 1.00 36.65 C \\\\nATOM 1380 CB ILE A 170 16.148 -10.534 -28.525 1.00 36.65 C \\\\nATOM 1381 O ILE A 170 16.703 -7.734 -26.495 1.00 36.65 O \\\\nATOM 1382 CG1 ILE A 170 16.237 -12.082 -28.648 1.00 36.65 C \\\\nATOM 1383 CG2 ILE A 170 17.054 -9.959 -29.631 1.00 36.65 C \\\\nATOM 1384 CD1 ILE A 170 15.229 -12.665 -29.647 1.00 36.65 C \\\\nATOM 1385 N GLU A 171 18.553 -8.749 -27.253 1.00 33.34 N \\\\nATOM 1386 CA GLU A 171 19.647 -7.827 -26.886 1.00 33.34 C \\\\nATOM 1387 C GLU A 171 19.508 -6.322 -27.262 1.00 33.34 C \\\\nATOM 1388 CB GLU A 171 20.912 -8.384 -27.563 1.00 33.34 C \\\\nATOM 1389 O GLU A 171 18.815 -5.979 -28.219 1.00 33.34 O \\\\nATOM 1390 CG GLU A 171 21.205 -9.850 -27.182 1.00 33.34 C \\\\nATOM 1391 CD GLU A 171 22.413 -10.424 -27.929 1.00 33.34 C \\\\nATOM 1392 OE1 GLU A 171 23.174 -11.173 -27.278 1.00 33.34 O \\\\nATOM 1393 OE2 GLU A 171 22.553 -10.127 -29.136 1.00 33.34 O \\\\nATOM 1394 N PRO A 172 20.211 -5.394 -26.564 1.00 32.49 N \\\\nATOM 1395 CA PRO A 172 20.148 -3.952 -26.836 1.00 32.49 C \\\\nATOM 1396 C PRO A 172 21.300 -3.415 -27.713 1.00 32.49 C \\\\nATOM 1397 CB PRO A 172 20.199 -3.318 -25.443 1.00 32.49 C \\\\nATOM 1398 O PRO A 172 22.469 -3.712 -27.466 1.00 32.49 O \\\\nATOM 1399 CG PRO A 172 21.162 -4.236 -24.683 1.00 32.49 C \\\\nATOM 1400 CD PRO A 172 20.926 -5.616 -25.309 1.00 32.49 C \\\\nATOM 1401 N GLN A 173 21.001 -2.487 -28.635 1.00 36.11 N \\\\nATOM 1402 CA GLN A 173 22.011 -1.656 -29.317 1.00 36.11 C \\\\nATOM 1403 C GLN A 173 21.726 -0.141 -29.211 1.00 36.11 C \\\\nATOM 1404 CB GLN A 173 22.234 -2.115 -30.772 1.00 36.11 C \\\\nATOM 1405 O GLN A 173 20.910 0.426 -29.924 1.00 36.11 O \\\\nATOM 1406 CG GLN A 173 23.064 -3.412 -30.836 1.00 36.11 C \\\\nATOM 1407 CD GLN A 173 23.549 -3.774 -32.240 1.00 36.11 C \\\\nATOM 1408 NE2 GLN A 173 24.380 -4.785 -32.370 1.00 36.11 N \\\\nATOM 1409 OE1 GLN A 173 23.215 -3.168 -33.243 1.00 36.11 O \\\\nATOM 1410 N SER A 174 22.463 0.497 -28.294 1.00 35.78 N \\\\nATOM 1411 CA SER A 174 23.201 1.768 -28.464 1.00 35.78 C \\\\nATOM 1412 C SER A 174 22.584 3.014 -29.161 1.00 35.78 C \\\\nATOM 1413 CB SER A 174 24.544 1.424 -29.129 1.00 35.78 C \\\\nATOM 1414 O SER A 174 22.504 3.069 -30.383 1.00 35.78 O \\\\nATOM 1415 OG SER A 174 24.359 0.851 -30.404 1.00 35.78 O \\\\nATOM 1416 N ASN A 175 22.484 4.104 -28.369 1.00 35.08 N \\\\nATOM 1417 CA ASN A 175 23.258 5.374 -28.501 1.00 35.08 C \\\\nATOM 1418 C ASN A 175 22.610 6.746 -28.897 1.00 35.08 C \\\\nATOM 1419 CB ASN A 175 24.603 5.154 -29.250 1.00 35.08 C \\\\nATOM 1420 O ASN A 175 22.404 7.013 -30.071 1.00 35.08 O \\\\nATOM 1421 CG ASN A 175 25.726 4.615 -28.377 1.00 35.08 C \\\\nATOM 1422 ND2 ASN A 175 26.864 4.315 -28.954 1.00 35.08 N \\\\nATOM 1423 OD1 ASN A 175 25.602 4.449 -27.175 1.00 35.08 O \\\\nATOM 1424 N ILE A 176 22.622 7.684 -27.909 1.00 42.21 N \\\\nATOM 1425 CA ILE A 176 23.071 9.121 -27.980 1.00 42.21 C \\\\nATOM 1426 C ILE A 176 22.116 10.155 -28.683 1.00 42.21 C \\\\nATOM 1427 CB ILE A 176 24.533 9.124 -28.560 1.00 42.21 C \\\\nATOM 1428 O ILE A 176 21.554 9.825 -29.717 1.00 42.21 O \\\\nATOM 1429 CG1 ILE A 176 25.528 8.202 -27.803 1.00 42.21 C \\\\nATOM 1430 CG2 ILE A 176 25.248 10.481 -28.601 1.00 42.21 C \\\\nATOM 1431 CD1 ILE A 176 26.821 7.896 -28.587 1.00 42.21 C \\\\nATOM 1432 N PRO A 177 21.984 11.451 -28.260 1.00 34.10 N \\\\nATOM 1433 CA PRO A 177 21.878 12.076 -26.925 1.00 34.10 C \\\\nATOM 1434 C PRO A 177 20.748 13.164 -26.840 1.00 34.10 C \\\\nATOM 1435 CB PRO A 177 23.238 12.758 -26.772 1.00 34.10 C \\\\nATOM 1436 O PRO A 177 19.832 13.216 -27.651 1.00 34.10 O \\\\nATOM 1437 CG PRO A 177 23.430 13.356 -28.173 1.00 34.10 C \\\\nATOM 1438 CD PRO A 177 22.508 12.528 -29.094 1.00 34.10 C \\\\nATOM 1439 N GLU A 178 20.803 14.056 -25.840 1.00 31.22 N \\\\nATOM 1440 CA GLU A 178 19.766 15.049 -25.493 1.00 31.22 C \\\\nATOM 1441 C GLU A 178 19.873 16.441 -26.160 1.00 31.22 C \\\\nATOM 1442 CB GLU A 178 19.800 15.310 -23.972 1.00 31.22 C \\\\nATOM 1443 O GLU A 178 20.954 17.024 -26.197 1.00 31.22 O \\\\nATOM 1444 CG GLU A 178 19.939 14.061 -23.097 1.00 31.22 C \\\\nATOM 1445 CD GLU A 178 19.667 14.394 -21.630 1.00 31.22 C \\\\nATOM 1446 OE1 GLU A 178 18.475 14.276 -21.249 1.00 31.22 O \\\\nATOM 1447 OE2 GLU A 178 20.612 14.760 -20.908 1.00 31.22 O \\\\nATOM 1448 N THR A 179 18.718 17.054 -26.467 1.00 36.45 N \\\\nATOM 1449 CA THR A 179 18.493 18.520 -26.512 1.00 36.45 C \\\\nATOM 1450 C THR A 179 17.057 18.880 -26.052 1.00 36.45 C \\\\nATOM 1451 CB THR A 179 18.724 19.135 -27.909 1.00 36.45 C \\\\nATOM 1452 O THR A 179 16.109 18.175 -26.403 1.00 36.45 O \\\\nATOM 1453 CG2 THR A 179 20.193 19.431 -28.204 1.00 36.45 C \\\\nATOM 1454 OG1 THR A 179 18.255 18.284 -28.926 1.00 36.45 O \\\\nATOM 1455 N PRO A 180 16.865 19.933 -25.227 1.00 38.72 N \\\\nATOM 1456 CA PRO A 180 15.547 20.523 -24.897 1.00 38.72 C \\\\nATOM 1457 C PRO A 180 15.526 22.074 -25.039 1.00 38.72 C \\\\nATOM 1458 CB PRO A 180 15.411 20.132 -23.420 1.00 38.72 C \\\\nATOM 1459 O PRO A 180 16.585 22.664 -25.249 1.00 38.72 O \\\\nATOM 1460 CG PRO A 180 16.821 20.396 -22.876 1.00 38.72 C \\\\nATOM 1461 CD PRO A 180 17.742 20.136 -24.075 1.00 38.72 C \\\\nATOM 1462 N PRO A 181 14.425 22.785 -24.695 1.00 44.75 N \\\\nATOM 1463 CA PRO A 181 12.998 22.573 -24.970 1.00 44.75 C \\\\nATOM 1464 C PRO A 181 12.578 23.642 -26.037 1.00 44.75 C \\\\nATOM 1465 CB PRO A 181 12.406 22.621 -23.564 1.00 44.75 C \\\\nATOM 1466 O PRO A 181 13.211 23.555 -27.088 1.00 44.75 O \\\\nATOM 1467 CG PRO A 181 13.195 23.757 -22.893 1.00 44.75 C \\\\nATOM 1468 CD PRO A 181 14.509 23.832 -23.686 1.00 44.75 C \\\\nATOM 1469 N PRO A 182 11.679 24.667 -25.892 1.00 38.69 N \\\\nATOM 1470 CA PRO A 182 10.580 25.008 -24.958 1.00 38.69 C \\\\nATOM 1471 C PRO A 182 9.177 24.739 -25.580 1.00 38.69 C \\\\nATOM 1472 CB PRO A 182 10.839 26.493 -24.650 1.00 38.69 C \\\\nATOM 1473 O PRO A 182 9.040 23.844 -26.406 1.00 38.69 O \\\\nATOM 1474 CG PRO A 182 11.386 27.063 -25.956 1.00 38.69 C \\\\nATOM 1475 CD PRO A 182 11.791 25.833 -26.773 1.00 38.69 C \\\\nATOM 1476 N GLY A 183 8.136 25.483 -25.169 1.00 30.01 N \\\\nATOM 1477 CA GLY A 183 6.812 25.582 -25.824 1.00 30.01 C \\\\nATOM 1478 C GLY A 183 6.240 27.004 -25.675 1.00 30.01 C \\\\nATOM 1479 O GLY A 183 6.944 27.820 -25.092 1.00 30.01 O \\\\nATOM 1480 N TYR A 184 5.022 27.310 -26.155 1.00 39.51 N \\\\nATOM 1481 CA TYR A 184 4.191 28.473 -25.752 1.00 39.51 C \\\\nATOM 1482 C TYR A 184 2.738 28.354 -26.304 1.00 39.51 C \\\\nATOM 1483 CB TYR A 184 4.832 29.829 -26.159 1.00 39.51 C \\\\nATOM 1484 O TYR A 184 2.514 27.690 -27.308 1.00 39.51 O \\\\nATOM 1485 CG TYR A 184 5.058 30.825 -25.014 1.00 39.51 C \\\\nATOM 1486 CD1 TYR A 184 4.208 31.938 -24.856 1.00 39.51 C \\\\nATOM 1487 CD2 TYR A 184 6.147 30.684 -24.126 1.00 39.51 C \\\\nATOM 1488 CE1 TYR A 184 4.418 32.858 -23.805 1.00 39.51 C \\\\nATOM 1489 CE2 TYR A 184 6.360 31.588 -23.072 1.00 39.51 C \\\\nATOM 1490 OH TYR A 184 5.701 33.561 -21.892 1.00 39.51 O \\\\nATOM 1491 CZ TYR A 184 5.489 32.680 -22.905 1.00 39.51 C \\\\nATOM 1492 N LEU A 185 1.807 28.987 -25.580 1.00 35.19 N \\\\nATOM 1493 CA LEU A 185 0.381 29.350 -25.789 1.00 35.19 C \\\\nATOM 1494 C LEU A 185 -0.415 29.022 -27.091 1.00 35.19 C \\\\nATOM 1495 CB LEU A 185 0.305 30.876 -25.571 1.00 35.19 C \\\\nATOM 1496 O LEU A 185 -0.010 29.385 -28.186 1.00 35.19 O \\\\nATOM 1497 CG LEU A 185 0.771 31.371 -24.187 1.00 35.19 C \\\\nATOM 1498 CD1 LEU A 185 0.821 32.896 -24.155 1.00 35.19 C \\\\nATOM 1499 CD2 LEU A 185 -0.152 30.898 -23.064 1.00 35.19 C \\\\nATOM 1500 N SER A 186 -1.622 28.473 -26.858 1.00 34.39 N \\\\nATOM 1501 CA SER A 186 -2.988 28.878 -27.296 1.00 34.39 C \\\\nATOM 1502 C SER A 186 -3.303 29.479 -28.681 1.00 34.39 C \\\\nATOM 1503 CB SER A 186 -3.534 29.907 -26.294 1.00 34.39 C \\\\nATOM 1504 O SER A 186 -2.736 30.504 -29.031 1.00 34.39 O \\\\nATOM 1505 OG SER A 186 -3.317 29.516 -24.945 1.00 34.39 O \\\\nATOM 1506 N GLU A 187 -4.399 29.001 -29.302 1.00 39.49 N \\\\nATOM 1507 CA GLU A 187 -5.525 29.837 -29.798 1.00 39.49 C \\\\nATOM 1508 C GLU A 187 -6.809 29.001 -30.054 1.00 39.49 C \\\\nATOM 1509 CB GLU A 187 -5.139 30.702 -31.023 1.00 39.49 C \\\\nATOM 1510 O GLU A 187 -6.735 27.781 -30.217 1.00 39.49 O \\\\nATOM 1511 CG GLU A 187 -5.129 32.188 -30.606 1.00 39.49 C \\\\nATOM 1512 CD GLU A 187 -4.650 33.164 -31.695 1.00 39.49 C \\\\nATOM 1513 OE1 GLU A 187 -5.250 34.262 -31.783 1.00 39.49 O \\\\nATOM 1514 OE2 GLU A 187 -3.662 32.854 -32.400 1.00 39.49 O \\\\nATOM 1515 N ASP A 188 -7.981 29.651 -30.011 1.00 34.92 N \\\\nATOM 1516 CA ASP A 188 -9.330 29.047 -29.984 1.00 34.92 C \\\\nATOM 1517 C ASP A 188 -9.981 28.853 -31.376 1.00 34.92 C \\\\nATOM 1518 CB ASP A 188 -10.245 29.934 -29.116 1.00 34.92 C \\\\nATOM 1519 O ASP A 188 -9.538 29.415 -32.378 1.00 34.92 O \\\\nATOM 1520 CG ASP A 188 -9.788 30.022 -27.658 1.00 34.92 C \\\\nATOM 1521 OD1 ASP A 188 -9.987 29.023 -26.931 1.00 34.92 O \\\\nATOM 1522 OD2 ASP A 188 -9.236 31.080 -27.276 1.00 34.92 O \\\\nATOM 1523 N GLY A 189 -11.098 28.109 -31.437 1.00 37.79 N \\\\nATOM 1524 CA GLY A 189 -11.931 27.992 -32.644 1.00 37.79 C \\\\nATOM 1525 C GLY A 189 -13.313 27.363 -32.408 1.00 37.79 C \\\\nATOM 1526 O GLY A 189 -13.435 26.143 -32.331 1.00 37.79 O \\\\nATOM 1527 N GLU A 190 -14.361 28.192 -32.341 1.00 33.29 N \\\\nATOM 1528 CA GLU A 190 -15.779 27.783 -32.283 1.00 33.29 C \\\\nATOM 1529 C GLU A 190 -16.458 27.848 -33.669 1.00 33.29 C \\\\nATOM 1530 CB GLU A 190 -16.569 28.709 -31.334 1.00 33.29 C \\\\nATOM 1531 O GLU A 190 -16.091 28.687 -34.487 1.00 33.29 O \\\\nATOM 1532 CG GLU A 190 -16.107 28.723 -29.870 1.00 33.29 C \\\\nATOM 1533 CD GLU A 190 -17.007 29.639 -29.018 1.00 33.29 C \\\\nATOM 1534 OE1 GLU A 190 -17.574 29.139 -28.019 1.00 33.29 O \\\\nATOM 1535 OE2 GLU A 190 -17.140 30.831 -29.380 1.00 33.29 O \\\\nATOM 1536 N THR A 191 -17.458 26.990 -33.929 1.00 42.71 N \\\\nATOM 1537 CA THR A 191 -18.598 27.103 -34.895 1.00 42.71 C \\\\nATOM 1538 C THR A 191 -19.276 25.716 -35.016 1.00 42.71 C \\\\nATOM 1539 CB THR A 191 -18.207 27.533 -36.336 1.00 42.71 C \\\\nATOM 1540 O THR A 191 -18.584 24.710 -34.902 1.00 42.71 O \\\\nATOM 1541 CG2 THR A 191 -18.196 29.048 -36.589 1.00 42.71 C \\\\nATOM 1542 OG1 THR A 191 -16.938 27.058 -36.710 1.00 42.71 O \\\\nATOM 1543 N SER A 192 -20.579 25.502 -35.263 1.00 40.70 N \\\\nATOM 1544 CA SER A 192 -21.818 26.304 -35.160 1.00 40.70 C \\\\nATOM 1545 C SER A 192 -23.040 25.348 -35.172 1.00 40.70 C \\\\nATOM 1546 CB SER A 192 -21.980 27.261 -36.348 1.00 40.70 C \\\\nATOM 1547 O SER A 192 -22.941 24.232 -35.679 1.00 40.70 O \\\\nATOM 1548 OG SER A 192 -21.283 28.465 -36.112 1.00 40.70 O \\\\nATOM 1549 N ASP A 193 -24.191 25.782 -34.643 1.00 32.70 N \\\\nATOM 1550 CA ASP A 193 -25.446 25.002 -34.558 1.00 32.70 C \\\\nATOM 1551 C ASP A 193 -26.161 24.721 -35.895 1.00 32.70 C \\\\nATOM 1552 CB ASP A 193 -26.463 25.781 -33.704 1.00 32.70 C \\\\nATOM 1553 O ASP A 193 -26.122 25.534 -36.818 1.00 32.70 O \\\\nATOM 1554 CG ASP A 193 -26.155 25.743 -32.216 1.00 32.70 C \\\\nATOM 1555 OD1 ASP A 193 -26.245 24.629 -31.656 1.00 32.70 O \\\\nATOM 1556 OD2 ASP A 193 -25.885 26.830 -31.664 1.00 32.70 O \\\\nATOM 1557 N HIS A 194 -26.991 23.664 -35.917 1.00 43.62 N \\\\nATOM 1558 CA HIS A 194 -28.169 23.580 -36.797 1.00 43.62 C \\\\nATOM 1559 C HIS A 194 -29.393 22.927 -36.111 1.00 43.62 C \\\\nATOM 1560 CB HIS A 194 -27.822 22.876 -38.123 1.00 43.62 C \\\\nATOM 1561 O HIS A 194 -29.395 21.740 -35.792 1.00 43.62 O \\\\nATOM 1562 CG HIS A 194 -27.307 23.818 -39.187 1.00 43.62 C \\\\nATOM 1563 CD2 HIS A 194 -26.093 23.766 -39.821 1.00 43.62 C \\\\nATOM 1564 ND1 HIS A 194 -27.980 24.906 -39.701 1.00 43.62 N \\\\nATOM 1565 CE1 HIS A 194 -27.186 25.497 -40.608 1.00 43.62 C \\\\nATOM 1566 NE2 HIS A 194 -26.036 24.823 -40.740 1.00 43.62 N \\\\nATOM 1567 N GLN A 195 -30.471 23.707 -35.955 1.00 34.38 N \\\\nATOM 1568 CA GLN A 195 -31.841 23.260 -35.637 1.00 34.38 C \\\\nATOM 1569 C GLN A 195 -32.716 23.226 -36.901 1.00 34.38 C \\\\nATOM 1570 CB GLN A 195 -32.523 24.269 -34.690 1.00 34.38 C \\\\nATOM 1571 O GLN A 195 -32.548 24.103 -37.742 1.00 34.38 O \\\\nATOM 1572 CG GLN A 195 -32.220 24.116 -33.198 1.00 34.38 C \\\\nATOM 1573 CD GLN A 195 -32.992 25.136 -32.354 1.00 34.38 C \\\\nATOM 1574 NE2 GLN A 195 -32.890 25.070 -31.046 1.00 34.38 N \\\\nATOM 1575 OE1 GLN A 195 -33.706 26.001 -32.834 1.00 34.38 O \\\\nATOM 1576 N MET A 196 -33.689 22.298 -36.971 1.00 43.58 N \\\\nATOM 1577 CA MET A 196 -34.997 22.344 -37.686 1.00 43.58 C \\\\nATOM 1578 C MET A 196 -35.638 20.930 -37.660 1.00 43.58 C \\\\nATOM 1579 CB MET A 196 -34.835 22.770 -39.167 1.00 43.58 C \\\\nATOM 1580 O MET A 196 -34.898 19.954 -37.655 1.00 43.58 O \\\\nATOM 1581 CG MET A 196 -34.842 24.298 -39.367 1.00 43.58 C \\\\nATOM 1582 SD MET A 196 -36.152 24.997 -40.407 1.00 43.58 S \\\\nATOM 1583 CE MET A 196 -35.694 26.747 -40.262 1.00 43.58 C \\\\nATOM 1584 N ASN A 197 -36.958 20.690 -37.705 1.00 41.11 N \\\\nATOM 1585 CA ASN A 197 -38.153 21.466 -37.322 1.00 41.11 C \\\\nATOM 1586 C ASN A 197 -39.364 20.485 -37.186 1.00 41.11 C \\\\nATOM 1587 CB ASN A 197 -38.439 22.571 -38.361 1.00 41.11 C \\\\nATOM 1588 O ASN A 197 -39.254 19.313 -37.540 1.00 41.11 O \\\\nATOM 1589 CG ASN A 197 -39.298 23.710 -37.834 1.00 41.11 C \\\\nATOM 1590 ND2 ASN A 197 -39.465 24.753 -38.609 1.00 41.11 N \\\\nATOM 1591 OD1 ASN A 197 -39.813 23.690 -36.728 1.00 41.11 O \\\\nATOM 1592 N HIS A 198 -40.511 20.944 -36.673 1.00 40.12 N \\\\nATOM 1593 CA HIS A 198 -41.731 20.157 -36.393 1.00 40.12 C \\\\nATOM 1594 C HIS A 198 -42.478 19.583 -37.619 1.00 40.12 C \\\\nATOM 1595 CB HIS A 198 -42.733 21.089 -35.691 1.00 40.12 C \\\\nATOM 1596 O HIS A 198 -42.436 20.176 -38.696 1.00 40.12 O \\\\nATOM 1597 CG HIS A 198 -42.362 21.505 -34.298 1.00 40.12 C \\\\nATOM 1598 CD2 HIS A 198 -41.690 22.640 -33.929 1.00 40.12 C \\\\nATOM 1599 ND1 HIS A 198 -42.742 20.860 -33.143 1.00 40.12 N \\\\nATOM 1600 CE1 HIS A 198 -42.304 21.586 -32.102 1.00 40.12 C \\\\nATOM 1601 NE2 HIS A 198 -41.659 22.679 -32.531 1.00 40.12 N \\\\nATOM 1602 N SER A 199 -43.319 18.552 -37.397 1.00 44.95 N \\\\nATOM 1603 CA SER A 199 -44.767 18.530 -37.752 1.00 44.95 C \\\\nATOM 1604 C SER A 199 -45.504 17.297 -37.184 1.00 44.95 C \\\\nATOM 1605 CB SER A 199 -45.013 18.600 -39.264 1.00 44.95 C \\\\nATOM 1606 O SER A 199 -44.880 16.278 -36.905 1.00 44.95 O \\\\nATOM 1607 OG SER A 199 -44.858 19.940 -39.677 1.00 44.95 O \\\\nATOM 1608 N MET A 200 -46.827 17.399 -36.996 1.00 45.79 N \\\\nATOM 1609 CA MET A 200 -47.737 16.340 -36.510 1.00 45.79 C \\\\nATOM 1610 C MET A 200 -48.777 15.996 -37.591 1.00 45.79 C \\\\nATOM 1611 CB MET A 200 -48.544 16.849 -35.293 1.00 45.79 C \\\\nATOM 1612 O MET A 200 -49.139 16.913 -38.320 1.00 45.79 O \\\\nATOM 1613 CG MET A 200 -47.745 17.422 -34.119 1.00 45.79 C \\\\nATOM 1614 SD MET A 200 -48.821 18.013 -32.777 1.00 45.79 S \\\\nATOM 1615 CE MET A 200 -47.596 18.699 -31.636 1.00 45.79 C \\\\nATOM 1616 N ASP A 201 -49.331 14.771 -37.623 1.00 46.67 N \\\\nATOM 1617 CA ASP A 201 -50.800 14.576 -37.689 1.00 46.67 C \\\\nATOM 1618 C ASP A 201 -51.266 13.129 -37.369 1.00 46.67 C \\\\nATOM 1619 CB ASP A 201 -51.455 15.079 -38.999 1.00 46.67 C \\\\nATOM 1620 O ASP A 201 -50.450 12.229 -37.159 1.00 46.67 O \\\\nATOM 1621 CG ASP A 201 -52.680 15.954 -38.674 1.00 46.67 C \\\\nATOM 1622 OD1 ASP A 201 -53.380 15.616 -37.687 1.00 46.67 O \\\\nATOM 1623 OD2 ASP A 201 -52.926 16.935 -39.408 1.00 46.67 O \\\\nATOM 1624 N ALA A 202 -52.585 12.935 -37.251 1.00 43.71 N \\\\nATOM 1625 CA ALA A 202 -53.251 11.820 -36.563 1.00 43.71 C \\\\nATOM 1626 C ALA A 202 -53.674 10.601 -37.424 1.00 43.71 C \\\\nATOM 1627 CB ALA A 202 -54.477 12.426 -35.864 1.00 43.71 C \\\\nATOM 1628 O ALA A 202 -53.850 10.694 -38.636 1.00 43.71 O \\\\nATOM 1629 N GLY A 203 -53.959 9.462 -36.762 1.00 40.70 N \\\\nATOM 1630 CA GLY A 203 -54.671 8.322 -37.373 1.00 40.70 C \\\\nATOM 1631 C GLY A 203 -54.584 6.979 -36.622 1.00 40.70 C \\\\nATOM 1632 O GLY A 203 -53.621 6.241 -36.779 1.00 40.70 O \\\\nATOM 1633 N SER A 204 -55.635 6.626 -35.875 1.00 42.76 N \\\\nATOM 1634 CA SER A 204 -55.953 5.263 -35.375 1.00 42.76 C \\\\nATOM 1635 C SER A 204 -57.215 4.749 -36.114 1.00 42.76 C \\\\nATOM 1636 CB SER A 204 -56.175 5.346 -33.854 1.00 42.76 C \\\\nATOM 1637 O SER A 204 -57.909 5.613 -36.658 1.00 42.76 O \\\\nATOM 1638 OG SER A 204 -54.953 5.182 -33.165 1.00 42.76 O \\\\nATOM 1639 N PRO A 205 -57.600 3.440 -36.129 1.00 46.18 N \\\\nATOM 1640 CA PRO A 205 -57.311 2.419 -35.103 1.00 46.18 C \\\\nATOM 1641 C PRO A 205 -57.072 0.946 -35.563 1.00 46.18 C \\\\nATOM 1642 CB PRO A 205 -58.634 2.448 -34.321 1.00 46.18 C \\\\nATOM 1643 O PRO A 205 -57.305 0.567 -36.703 1.00 46.18 O \\\\nATOM 1644 CG PRO A 205 -59.689 2.523 -35.436 1.00 46.18 C \\\\nATOM 1645 CD PRO A 205 -58.931 3.098 -36.637 1.00 46.18 C \\\\nATOM 1646 N ASN A 206 -56.707 0.107 -34.579 1.00 39.37 N \\\\nATOM 1647 CA ASN A 206 -57.019 -1.327 -34.383 1.00 39.37 C \\\\nATOM 1648 C ASN A 206 -57.092 -2.311 -35.573 1.00 39.37 C \\\\nATOM 1649 CB ASN A 206 -58.360 -1.430 -33.622 1.00 39.37 C \\\\nATOM 1650 O ASN A 206 -58.089 -2.336 -36.285 1.00 39.37 O \\\\nATOM 1651 CG ASN A 206 -58.338 -0.871 -32.217 1.00 39.37 C \\\\nATOM 1652 ND2 ASN A 206 -59.478 -0.807 -31.571 1.00 39.37 N \\\\nATOM 1653 OD1 ASN A 206 -57.317 -0.484 -31.679 1.00 39.37 O \\\\nATOM 1654 N LEU A 207 -56.196 -3.312 -35.564 1.00 44.78 N \\\\nATOM 1655 CA LEU A 207 -56.487 -4.720 -35.904 1.00 44.78 C \\\\nATOM 1656 C LEU A 207 -55.433 -5.648 -35.248 1.00 44.78 C \\\\nATOM 1657 CB LEU A 207 -56.518 -4.928 -37.441 1.00 44.78 C \\\\nATOM 1658 O LEU A 207 -54.266 -5.622 -35.625 1.00 44.78 O \\\\nATOM 1659 CG LEU A 207 -57.917 -4.971 -38.099 1.00 44.78 C \\\\nATOM 1660 CD1 LEU A 207 -57.771 -4.972 -39.620 1.00 44.78 C \\\\nATOM 1661 CD2 LEU A 207 -58.716 -6.216 -37.699 1.00 44.78 C \\\\nATOM 1662 N SER A 208 -55.842 -6.478 -34.284 1.00 40.73 N \\\\nATOM 1663 CA SER A 208 -55.055 -7.621 -33.762 1.00 40.73 C \\\\nATOM 1664 C SER A 208 -55.432 -8.888 -34.557 1.00 40.73 C \\\\nATOM 1665 CB SER A 208 -55.324 -7.826 -32.261 1.00 40.73 C \\\\nATOM 1666 O SER A 208 -56.579 -8.945 -35.011 1.00 40.73 O \\\\nATOM 1667 OG SER A 208 -55.350 -6.605 -31.544 1.00 40.73 O \\\\nATOM 1668 N PRO A 209 -54.570 -9.926 -34.702 1.00 44.83 N \\\\nATOM 1669 CA PRO A 209 -54.400 -10.888 -33.596 1.00 44.83 C \\\\nATOM 1670 C PRO A 209 -53.067 -11.690 -33.521 1.00 44.83 C \\\\nATOM 1671 CB PRO A 209 -55.548 -11.872 -33.862 1.00 44.83 C \\\\nATOM 1672 O PRO A 209 -52.260 -11.716 -34.441 1.00 44.83 O \\\\nATOM 1673 CG PRO A 209 -55.517 -12.030 -35.384 1.00 44.83 C \\\\nATOM 1674 CD PRO A 209 -54.779 -10.779 -35.876 1.00 44.83 C \\\\nATOM 1675 N ASN A 210 -52.975 -12.466 -32.431 1.00 41.10 N \\\\nATOM 1676 CA ASN A 210 -52.140 -13.654 -32.163 1.00 41.10 C \\\\nATOM 1677 C ASN A 210 -50.635 -13.492 -31.825 1.00 41.10 C \\\\nATOM 1678 CB ASN A 210 -52.397 -14.760 -33.202 1.00 41.10 C \\\\nATOM 1679 O ASN A 210 -49.853 -13.017 -32.644 1.00 41.10 O \\\\nATOM 1680 CG ASN A 210 -53.775 -15.385 -33.076 1.00 41.10 C \\\\nATOM 1681 ND2 ASN A 210 -54.098 -16.329 -33.926 1.00 41.10 N \\\\nATOM 1682 OD1 ASN A 210 -54.574 -15.061 -32.210 1.00 41.10 O \\\\nATOM 1683 N PRO A 211 -50.195 -13.989 -30.644 1.00 40.72 N \\\\nATOM 1684 CA PRO A 211 -48.784 -14.075 -30.279 1.00 40.72 C \\\\nATOM 1685 C PRO A 211 -48.138 -15.368 -30.802 1.00 40.72 C \\\\nATOM 1686 CB PRO A 211 -48.777 -14.031 -28.748 1.00 40.72 C \\\\nATOM 1687 O PRO A 211 -48.693 -16.457 -30.648 1.00 40.72 O \\\\nATOM 1688 CG PRO A 211 -50.056 -14.780 -28.371 1.00 40.72 C \\\\nATOM 1689 CD PRO A 211 -51.010 -14.460 -29.524 1.00 40.72 C \\\\nATOM 1690 N MET A 212 -46.921 -15.265 -31.338 1.00 42.15 N \\\\nATOM 1691 CA MET A 212 -46.016 -16.412 -31.467 1.00 42.15 C \\\\nATOM 1692 C MET A 212 -45.120 -16.483 -30.229 1.00 42.15 C \\\\nATOM 1693 CB MET A 212 -45.197 -16.341 -32.766 1.00 42.15 C \\\\nATOM 1694 O MET A 212 -44.534 -15.481 -29.822 1.00 42.15 O \\\\nATOM 1695 CG MET A 212 -46.095 -16.597 -33.984 1.00 42.15 C \\\\nATOM 1696 SD MET A 212 -45.256 -16.690 -35.591 1.00 42.15 S \\\\nATOM 1697 CE MET A 212 -44.234 -18.174 -35.381 1.00 42.15 C \\\\nATOM 1698 N SER A 213 -45.035 -17.666 -29.621 1.00 39.51 N \\\\nATOM 1699 CA SER A 213 -44.201 -17.926 -28.446 1.00 39.51 C \\\\nATOM 1700 C SER A 213 -42.723 -17.623 -28.732 1.00 39.51 C \\\\nATOM 1701 CB SER A 213 -44.315 -19.400 -28.044 1.00 39.51 C \\\\nATOM 1702 O SER A 213 -42.234 -18.034 -29.788 1.00 39.51 O \\\\nATOM 1703 OG SER A 213 -45.673 -19.802 -27.981 1.00 39.51 O \\\\nATOM 1704 N PRO A 214 -41.972 -16.991 -27.810 1.00 42.72 N \\\\nATOM 1705 CA PRO A 214 -40.527 -16.881 -27.955 1.00 42.72 C \\\\nATOM 1706 C PRO A 214 -39.909 -18.278 -27.898 1.00 42.72 C \\\\nATOM 1707 CB PRO A 214 -40.030 -16.000 -26.800 1.00 42.72 C \\\\nATOM 1708 O PRO A 214 -40.210 -19.057 -26.990 1.00 42.72 O \\\\nATOM 1709 CG PRO A 214 -41.299 -15.382 -26.214 1.00 42.72 C \\\\nATOM 1710 CD PRO A 214 -42.392 -16.393 -26.555 1.00 42.72 C \\\\nATOM 1711 N ALA A 215 -39.018 -18.593 -28.837 1.00 38.54 N \\\\nATOM 1712 CA ALA A 215 -38.164 -19.761 -28.699 1.00 38.54 C \\\\nATOM 1713 C ALA A 215 -37.263 -19.558 -27.471 1.00 38.54 C \\\\nATOM 1714 CB ALA A 215 -37.366 -19.964 -29.993 1.00 38.54 C \\\\nATOM 1715 O ALA A 215 -36.411 -18.668 -27.457 1.00 38.54 O \\\\nATOM 1716 N HIS A 216 -37.455 -20.375 -26.433 1.00 40.42 N \\\\nATOM 1717 CA HIS A 216 -36.520 -20.447 -25.316 1.00 40.42 C \\\\nATOM 1718 C HIS A 216 -35.209 -21.071 -25.806 1.00 40.42 C \\\\nATOM 1719 CB HIS A 216 -37.123 -21.222 -24.129 1.00 40.42 C \\\\nATOM 1720 O HIS A 216 -35.005 -22.281 -25.704 1.00 40.42 O \\\\nATOM 1721 CG HIS A 216 -37.967 -20.379 -23.206 1.00 40.42 C \\\\nATOM 1722 CD2 HIS A 216 -39.316 -20.482 -22.997 1.00 40.42 C \\\\nATOM 1723 ND1 HIS A 216 -37.497 -19.419 -22.338 1.00 40.42 N \\\\nATOM 1724 CE1 HIS A 216 -38.538 -18.952 -21.629 1.00 40.42 C \\\\nATOM 1725 NE2 HIS A 216 -39.670 -19.572 -21.994 1.00 40.42 N \\\\nATOM 1726 N ASN A 217 -34.301 -20.230 -26.305 1.00 45.94 N \\\\nATOM 1727 CA ASN A 217 -32.886 -20.566 -26.348 1.00 45.94 C \\\\nATOM 1728 C ASN A 217 -32.417 -20.746 -24.900 1.00 45.94 C \\\\nATOM 1729 CB ASN A 217 -32.085 -19.479 -27.098 1.00 45.94 C \\\\nATOM 1730 O ASN A 217 -32.070 -19.777 -24.224 1.00 45.94 O \\\\nATOM 1731 CG ASN A 217 -32.078 -19.656 -28.607 1.00 45.94 C \\\\nATOM 1732 ND2 ASN A 217 -31.390 -18.796 -29.321 1.00 45.94 N \\\\nATOM 1733 OD1 ASN A 217 -32.661 -20.566 -29.167 1.00 45.94 O \\\\nATOM 1734 N ASN A 218 -32.422 -21.996 -24.430 1.00 48.29 N \\\\nATOM 1735 CA ASN A 218 -31.732 -22.420 -23.215 1.00 48.29 C \\\\nATOM 1736 C ASN A 218 -30.218 -22.322 -23.454 1.00 48.29 C \\\\nATOM 1737 CB ASN A 218 -32.196 -23.836 -22.795 1.00 48.29 C \\\\nATOM 1738 O ASN A 218 -29.524 -23.321 -23.636 1.00 48.29 O \\\\nATOM 1739 CG ASN A 218 -33.261 -23.865 -21.712 1.00 48.29 C \\\\nATOM 1740 ND2 ASN A 218 -33.691 -25.044 -21.328 1.00 48.29 N \\\\nATOM 1741 OD1 ASN A 218 -33.708 -22.868 -21.174 1.00 48.29 O \\\\nATOM 1742 N LEU A 219 -29.712 -21.090 -23.470 1.00 60.32 N \\\\nATOM 1743 CA LEU A 219 -28.303 -20.815 -23.246 1.00 60.32 C \\\\nATOM 1744 C LEU A 219 -27.998 -21.275 -21.819 1.00 60.32 C \\\\nATOM 1745 CB LEU A 219 -28.035 -19.313 -23.455 1.00 60.32 C \\\\nATOM 1746 O LEU A 219 -28.474 -20.677 -20.854 1.00 60.32 O \\\\nATOM 1747 CG LEU A 219 -28.042 -18.894 -24.937 1.00 60.32 C \\\\nATOM 1748 CD1 LEU A 219 -28.221 -17.382 -25.062 1.00 60.32 C \\\\nATOM 1749 CD2 LEU A 219 -26.732 -19.278 -25.630 1.00 60.32 C \\\\nATOM 1750 N ASP A 220 -27.247 -22.368 -21.699 1.00 74.45 N \\\\nATOM 1751 CA ASP A 220 -26.793 -22.909 -20.419 1.00 74.45 C \\\\nATOM 1752 C ASP A 220 -25.707 -21.976 -19.855 1.00 74.45 C \\\\nATOM 1753 CB ASP A 220 -26.366 -24.375 -20.612 1.00 74.45 C \\\\nATOM 1754 O ASP A 220 -24.509 -22.128 -20.106 1.00 74.45 O \\\\nATOM 1755 CG ASP A 220 -26.139 -25.137 -19.300 1.00 74.45 C \\\\nATOM 1756 OD1 ASP A 220 -26.610 -24.684 -18.235 1.00 74.45 O \\\\nATOM 1757 OD2 ASP A 220 -25.480 -26.202 -19.357 1.00 74.45 O \\\\nATOM 1758 N LEU A 221 -26.177 -20.912 -19.198 1.00 81.69 N \\\\nATOM 1759 CA LEU A 221 -25.384 -19.817 -18.652 1.00 81.69 C \\\\nATOM 1760 C LEU A 221 -24.868 -20.190 -17.261 1.00 81.69 C \\\\nATOM 1761 CB LEU A 221 -26.244 -18.539 -18.591 1.00 81.69 C \\\\nATOM 1762 O LEU A 221 -25.641 -20.307 -16.308 1.00 81.69 O \\\\nATOM 1763 CG LEU A 221 -26.532 -17.876 -19.951 1.00 81.69 C \\\\nATOM 1764 CD1 LEU A 221 -27.616 -16.809 -19.796 1.00 81.69 C \\\\nATOM 1765 CD2 LEU A 221 -25.300 -17.189 -20.537 1.00 81.69 C \\\\nATOM 1766 N GLN A 222 -23.551 -20.314 -17.121 1.00 85.05 N \\\\nATOM 1767 CA GLN A 222 -22.922 -20.623 -15.844 1.00 85.05 C \\\\nATOM 1768 C GLN A 222 -22.578 -19.327 -15.078 1.00 85.05 C \\\\nATOM 1769 CB GLN A 222 -21.723 -21.549 -16.088 1.00 85.05 C \\\\nATOM 1770 O GLN A 222 -21.875 -18.469 -15.616 1.00 85.05 O \\\\nATOM 1771 CG GLN A 222 -21.146 -22.068 -14.764 1.00 85.05 C \\\\nATOM 1772 CD GLN A 222 -20.201 -23.256 -14.935 1.00 85.05 C \\\\nATOM 1773 NE2 GLN A 222 -19.224 -23.405 -14.071 1.00 85.05 N \\\\nATOM 1774 OE1 GLN A 222 -20.361 -24.133 -15.776 1.00 85.05 O \\\\nATOM 1775 N PRO A 223 -23.056 -19.142 -13.830 1.00 90.37 N \\\\nATOM 1776 CA PRO A 223 -22.756 -17.950 -13.042 1.00 90.37 C \\\\nATOM 1777 C PRO A 223 -21.366 -18.020 -12.394 1.00 90.37 C \\\\nATOM 1778 CB PRO A 223 -23.877 -17.858 -12.003 1.00 90.37 C \\\\nATOM 1779 O PRO A 223 -21.036 -18.970 -11.681 1.00 90.37 O \\\\nATOM 1780 CG PRO A 223 -24.265 -19.319 -11.776 1.00 90.37 C \\\\nATOM 1781 CD PRO A 223 -24.053 -19.958 -13.149 1.00 90.37 C \\\\nATOM 1782 N VAL A 224 -20.577 -16.961 -12.571 1.00 90.45 N \\\\nATOM 1783 CA VAL A 224 -19.236 -16.791 -12.000 1.00 90.45 C \\\\nATOM 1784 C VAL A 224 -19.241 -15.674 -10.963 1.00 90.45 C \\\\nATOM 1785 CB VAL A 224 -18.185 -16.520 -13.094 1.00 90.45 C \\\\nATOM 1786 O VAL A 224 -19.332 -14.489 -11.293 1.00 90.45 O \\\\nATOM 1787 CG1 VAL A 224 -16.787 -16.560 -12.468 1.00 90.45 C \\\\nATOM 1788 CG2 VAL A 224 -18.242 -17.587 -14.185 1.00 90.45 C \\\\nATOM 1789 N THR A 225 -19.119 -16.047 -9.690 1.00 90.96 N \\\\nATOM 1790 CA THR A 225 -19.107 -15.113 -8.558 1.00 90.96 C \\\\nATOM 1791 C THR A 225 -17.708 -14.574 -8.245 1.00 90.96 C \\\\nATOM 1792 CB THR A 225 -19.718 -15.750 -7.299 1.00 90.96 C \\\\nATOM 1793 O THR A 225 -16.707 -15.306 -8.235 1.00 90.96 O \\\\nATOM 1794 CG2 THR A 225 -21.223 -15.974 -7.443 1.00 90.96 C \\\\nATOM 1795 OG1 THR A 225 -19.143 -17.012 -7.043 1.00 90.96 O \\\\nATOM 1796 N TYR A 226 -17.656 -13.279 -7.920 1.00 91.36 N \\\\nATOM 1797 CA TYR A 226 -16.485 -12.645 -7.317 1.00 91.36 C \\\\nATOM 1798 C TYR A 226 -16.177 -13.268 -5.947 1.00 91.36 C \\\\nATOM 1799 CB TYR A 226 -16.729 -11.137 -7.179 1.00 91.36 C \\\\nATOM 1800 O TYR A 226 -17.081 -13.659 -5.205 1.00 91.36 O \\\\nATOM 1801 CG TYR A 226 -15.526 -10.357 -6.675 1.00 91.36 C \\\\nATOM 1802 CD1 TYR A 226 -15.400 -10.011 -5.314 1.00 91.36 C \\\\nATOM 1803 CD2 TYR A 226 -14.536 -9.953 -7.586 1.00 91.36 C \\\\nATOM 1804 CE1 TYR A 226 -14.290 -9.258 -4.874 1.00 91.36 C \\\\nATOM 1805 CE2 TYR A 226 -13.447 -9.174 -7.158 1.00 91.36 C \\\\nATOM 1806 OH TYR A 226 -12.242 -8.086 -5.408 1.00 91.36 O \\\\nATOM 1807 CZ TYR A 226 -13.310 -8.831 -5.798 1.00 91.36 C \\\\nATOM 1808 N CYS A 227 -14.896 -13.343 -5.592 1.00 88.04 N \\\\nATOM 1809 CA CYS A 227 -14.446 -13.685 -4.245 1.00 88.04 C \\\\nATOM 1810 C CYS A 227 -13.320 -12.729 -3.857 1.00 88.04 C \\\\nATOM 1811 CB CYS A 227 -13.971 -15.144 -4.176 1.00 88.04 C \\\\nATOM 1812 O CYS A 227 -12.443 -12.461 -4.673 1.00 88.04 O \\\\nATOM 1813 SG CYS A 227 -15.324 -16.288 -4.590 1.00 88.04 S \\\\nATOM 1814 N GLU A 228 -13.341 -12.228 -2.624 1.00 87.08 N \\\\nATOM 1815 CA GLU A 228 -12.293 -11.333 -2.136 1.00 87.08 C \\\\nATOM 1816 C GLU A 228 -11.044 -12.157 -1.749 1.00 87.08 C \\\\nATOM 1817 CB GLU A 228 -12.835 -10.504 -0.959 1.00 87.08 C \\\\nATOM 1818 O GLU A 228 -11.162 -13.089 -0.945 1.00 87.08 O \\\\nATOM 1819 CG GLU A 228 -12.081 -9.184 -0.760 1.00 87.08 C \\\\nATOM 1820 CD GLU A 228 -12.445 -8.166 -1.847 1.00 87.08 C \\\\nATOM 1821 OE1 GLU A 228 -11.724 -8.084 -2.862 1.00 87.08 O \\\\nATOM 1822 OE2 GLU A 228 -13.462 -7.454 -1.705 1.00 87.08 O \\\\nATOM 1823 N PRO A 229 -9.856 -11.871 -2.307 1.00 91.38 N \\\\nATOM 1824 CA PRO A 229 -8.630 -12.602 -1.993 1.00 91.38 C \\\\nATOM 1825 C PRO A 229 -8.013 -12.151 -0.659 1.00 91.38 C \\\\nATOM 1826 CB PRO A 229 -7.696 -12.322 -3.172 1.00 91.38 C \\\\nATOM 1827 O PRO A 229 -8.198 -11.022 -0.213 1.00 91.38 O \\\\nATOM 1828 CG PRO A 229 -8.092 -10.899 -3.553 1.00 91.38 C \\\\nATOM 1829 CD PRO A 229 -9.602 -10.891 -3.353 1.00 91.38 C \\\\nATOM 1830 N ALA A 230 -7.183 -13.009 -0.054 1.00 90.34 N \\\\nATOM 1831 CA ALA A 230 -6.465 -12.698 1.192 1.00 90.34 C \\\\nATOM 1832 C ALA A 230 -5.456 -11.533 1.066 1.00 90.34 C \\\\nATOM 1833 CB ALA A 230 -5.759 -13.977 1.660 1.00 90.34 C \\\\nATOM 1834 O ALA A 230 -5.130 -10.879 2.056 1.00 90.34 O \\\\nATOM 1835 N PHE A 231 -4.973 -11.272 -0.152 1.00 94.61 N \\\\nATOM 1836 CA PHE A 231 -4.199 -10.086 -0.509 1.00 94.61 C \\\\nATOM 1837 C PHE A 231 -4.930 -9.383 -1.649 1.00 94.61 C \\\\nATOM 1838 CB PHE A 231 -2.775 -10.474 -0.935 1.00 94.61 C \\\\nATOM 1839 O PHE A 231 -5.084 -9.979 -2.715 1.00 94.61 O \\\\nATOM 1840 CG PHE A 231 -1.985 -11.239 0.107 1.00 94.61 C \\\\nATOM 1841 CD1 PHE A 231 -1.300 -10.545 1.119 1.00 94.61 C \\\\nATOM 1842 CD2 PHE A 231 -1.917 -12.644 0.056 1.00 94.61 C \\\\nATOM 1843 CE1 PHE A 231 -0.547 -11.247 2.076 1.00 94.61 C \\\\nATOM 1844 CE2 PHE A 231 -1.170 -13.349 1.017 1.00 94.61 C \\\\nATOM 1845 CZ PHE A 231 -0.486 -12.650 2.027 1.00 94.61 C \\\\nATOM 1846 N TRP A 232 -5.376 -8.142 -1.456 1.00 95.43 N \\\\nATOM 1847 CA TRP A 232 -6.197 -7.431 -2.445 1.00 95.43 C \\\\nATOM 1848 C TRP A 232 -5.375 -6.933 -3.644 1.00 95.43 C \\\\nATOM 1849 CB TRP A 232 -6.971 -6.306 -1.752 1.00 95.43 C \\\\nATOM 1850 O TRP A 232 -5.883 -6.886 -4.766 1.00 95.43 O \\\\nATOM 1851 CG TRP A 232 -6.131 -5.200 -1.196 1.00 95.43 C \\\\nATOM 1852 CD1 TRP A 232 -5.652 -5.120 0.065 1.00 95.43 C \\\\nATOM 1853 CD2 TRP A 232 -5.664 -3.998 -1.878 1.00 95.43 C \\\\nATOM 1854 CE2 TRP A 232 -4.882 -3.233 -0.963 1.00 95.43 C \\\\nATOM 1855 CE3 TRP A 232 -5.831 -3.479 -3.180 1.00 95.43 C \\\\nATOM 1856 NE1 TRP A 232 -4.917 -3.961 0.205 1.00 95.43 N \\\\nATOM 1857 CH2 TRP A 232 -4.469 -1.529 -2.630 1.00 95.43 C \\\\nATOM 1858 CZ2 TRP A 232 -4.287 -2.015 -1.323 1.00 95.43 C \\\\nATOM 1859 CZ3 TRP A 232 -5.238 -2.259 -3.554 1.00 95.43 C \\\\nATOM 1860 N CYS A 233 -4.085 -6.643 -3.443 1.00 97.66 N \\\\nATOM 1861 CA CYS A 233 -3.142 -6.409 -4.533 1.00 97.66 C \\\\nATOM 1862 C CYS A 233 -1.744 -6.980 -4.268 1.00 97.66 C \\\\nATOM 1863 CB CYS A 233 -3.097 -4.915 -4.904 1.00 97.66 C \\\\nATOM 1864 O CYS A 233 -1.371 -7.311 -3.137 1.00 97.66 O \\\\nATOM 1865 SG CYS A 233 -2.220 -3.908 -3.672 1.00 97.66 S \\\\nATOM 1866 N SER A 234 -0.963 -7.073 -5.340 1.00 98.00 N \\\\nATOM 1867 CA SER A 234 0.484 -7.274 -5.297 1.00 98.00 C \\\\nATOM 1868 C SER A 234 1.196 -6.126 -6.021 1.00 98.00 C \\\\nATOM 1869 CB SER A 234 0.855 -8.653 -5.846 1.00 98.00 C \\\\nATOM 1870 O SER A 234 0.656 -5.569 -6.978 1.00 98.00 O \\\\nATOM 1871 OG SER A 234 0.561 -8.773 -7.220 1.00 98.00 O \\\\nATOM 1872 N ILE A 235 2.374 -5.727 -5.534 1.00 98.48 N \\\\nATOM 1873 CA ILE A 235 3.124 -4.561 -6.018 1.00 98.48 C \\\\nATOM 1874 C ILE A 235 4.563 -4.957 -6.337 1.00 98.48 C \\\\nATOM 1875 CB ILE A 235 3.083 -3.380 -5.017 1.00 98.48 C \\\\nATOM 1876 O ILE A 235 5.286 -5.443 -5.467 1.00 98.48 O \\\\nATOM 1877 CG1 ILE A 235 1.628 -3.071 -4.597 1.00 98.48 C \\\\nATOM 1878 CG2 ILE A 235 3.764 -2.146 -5.646 1.00 98.48 C \\\\nATOM 1879 CD1 ILE A 235 1.453 -1.811 -3.745 1.00 98.48 C \\\\nATOM 1880 N SER A 236 5.002 -4.695 -7.566 1.00 98.56 N \\\\nATOM 1881 CA SER A 236 6.394 -4.879 -7.998 1.00 98.56 C \\\\nATOM 1882 C SER A 236 7.045 -3.523 -8.282 1.00 98.56 C \\\\nATOM 1883 CB SER A 236 6.453 -5.806 -9.215 1.00 98.56 C \\\\nATOM 1884 O SER A 236 6.434 -2.671 -8.924 1.00 98.56 O \\\\nATOM 1885 OG SER A 236 5.926 -7.081 -8.879 1.00 98.56 O \\\\nATOM 1886 N TYR A 237 8.271 -3.307 -7.796 1.00 98.69 N \\\\nATOM 1887 CA TYR A 237 9.032 -2.067 -7.999 1.00 98.69 C \\\\nATOM 1888 C TYR A 237 10.047 -2.195 -9.137 1.00 98.69 C \\\\nATOM 1889 CB TYR A 237 9.692 -1.633 -6.680 1.00 98.69 C \\\\nATOM 1890 O TYR A 237 10.666 -3.245 -9.328 1.00 98.69 O \\\\nATOM 1891 CG TYR A 237 10.637 -0.444 -6.789 1.00 98.69 C \\\\nATOM 1892 CD1 TYR A 237 12.003 -0.597 -6.486 1.00 98.69 C \\\\nATOM 1893 CD2 TYR A 237 10.156 0.816 -7.191 1.00 98.69 C \\\\nATOM 1894 CE1 TYR A 237 12.878 0.503 -6.562 1.00 98.69 C \\\\nATOM 1895 CE2 TYR A 237 11.029 1.915 -7.294 1.00 98.69 C \\\\nATOM 1896 OH TYR A 237 13.219 2.844 -6.988 1.00 98.69 O \\\\nATOM 1897 CZ TYR A 237 12.391 1.765 -6.962 1.00 98.69 C \\\\nATOM 1898 N TYR A 238 10.217 -1.103 -9.881 1.00 98.77 N \\\\nATOM 1899 CA TYR A 238 11.071 -1.011 -11.053 1.00 98.77 C \\\\nATOM 1900 C TYR A 238 11.893 0.282 -11.053 1.00 98.77 C \\\\nATOM 1901 CB TYR A 238 10.215 -1.095 -12.322 1.00 98.77 C \\\\nATOM 1902 O TYR A 238 11.424 1.369 -10.693 1.00 98.77 O \\\\nATOM 1903 CG TYR A 238 9.557 -2.438 -12.582 1.00 98.77 C \\\\nATOM 1904 CD1 TYR A 238 10.127 -3.335 -13.507 1.00 98.77 C \\\\nATOM 1905 CD2 TYR A 238 8.351 -2.771 -11.935 1.00 98.77 C \\\\nATOM 1906 CE1 TYR A 238 9.513 -4.577 -13.760 1.00 98.77 C \\\\nATOM 1907 CE2 TYR A 238 7.751 -4.023 -12.163 1.00 98.77 C \\\\nATOM 1908 OH TYR A 238 7.774 -6.155 -13.249 1.00 98.77 O \\\\nATOM 1909 CZ TYR A 238 8.338 -4.934 -13.063 1.00 98.77 C \\\\nATOM 1910 N GLU A 239 13.128 0.159 -11.527 1.00 98.62 N \\\\nATOM 1911 CA GLU A 239 14.019 1.264 -11.862 1.00 98.62 C \\\\nATOM 1912 C GLU A 239 14.323 1.165 -13.362 1.00 98.62 C \\\\nATOM 1913 CB GLU A 239 15.284 1.228 -10.979 1.00 98.62 C \\\\nATOM 1914 O GLU A 239 14.958 0.211 -13.810 1.00 98.62 O \\\\nATOM 1915 CG GLU A 239 14.940 1.495 -9.500 1.00 98.62 C \\\\nATOM 1916 CD GLU A 239 16.132 1.483 -8.527 1.00 98.62 C \\\\nATOM 1917 OE1 GLU A 239 15.922 1.704 -7.311 1.00 98.62 O \\\\nATOM 1918 OE2 GLU A 239 17.306 1.282 -8.916 1.00 98.62 O \\\\nATOM 1919 N LEU A 240 13.834 2.127 -14.153 1.00 98.06 N \\\\nATOM 1920 CA LEU A 240 13.823 2.051 -15.621 1.00 98.06 C \\\\nATOM 1921 C LEU A 240 13.079 0.792 -16.117 1.00 98.06 C \\\\nATOM 1922 CB LEU A 240 15.248 2.233 -16.192 1.00 98.06 C \\\\nATOM 1923 O LEU A 240 11.916 0.600 -15.776 1.00 98.06 O \\\\nATOM 1924 CG LEU A 240 15.969 3.510 -15.728 1.00 98.06 C \\\\nATOM 1925 CD1 LEU A 240 17.434 3.448 -16.154 1.00 98.06 C \\\\nATOM 1926 CD2 LEU A 240 15.350 4.776 -16.327 1.00 98.06 C \\\\nATOM 1927 N ASN A 241 13.710 -0.073 -16.912 1.00 97.14 N \\\\nATOM 1928 CA ASN A 241 13.154 -1.360 -17.346 1.00 97.14 C \\\\nATOM 1929 C ASN A 241 13.502 -2.533 -16.405 1.00 97.14 C \\\\nATOM 1930 CB ASN A 241 13.596 -1.633 -18.797 1.00 97.14 C \\\\nATOM 1931 O ASN A 241 13.069 -3.658 -16.655 1.00 97.14 O \\\\nATOM 1932 CG ASN A 241 15.097 -1.813 -18.965 1.00 97.14 C \\\\nATOM 1933 ND2 ASN A 241 15.528 -2.374 -20.069 1.00 97.14 N \\\\nATOM 1934 OD1 ASN A 241 15.903 -1.420 -18.136 1.00 97.14 O \\\\nATOM 1935 N GLN A 242 14.276 -2.305 -15.340 1.00 97.90 N \\\\nATOM 1936 CA GLN A 242 14.739 -3.357 -14.439 1.00 97.90 C \\\\nATOM 1937 C GLN A 242 13.834 -3.473 -13.211 1.00 97.90 C \\\\nATOM 1938 CB GLN A 242 16.203 -3.092 -14.058 1.00 97.90 C \\\\nATOM 1939 O GLN A 242 13.608 -2.500 -12.494 1.00 97.90 O \\\\nATOM 1940 CG GLN A 242 16.783 -4.233 -13.207 1.00 97.90 C \\\\nATOM 1941 CD GLN A 242 18.248 -4.032 -12.846 1.00 97.90 C \\\\nATOM 1942 NE2 GLN A 242 18.831 -4.925 -12.081 1.00 97.90 N \\\\nATOM 1943 OE1 GLN A 242 18.908 -3.084 -13.238 1.00 97.90 O \\\\nATOM 1944 N ARG A 243 13.365 -4.690 -12.920 1.00 98.06 N \\\\nATOM 1945 CA ARG A 243 12.677 -5.004 -11.663 1.00 98.06 C \\\\nATOM 1946 C ARG A 243 13.668 -4.998 -10.495 1.00 98.06 C \\\\nATOM 1947 CB ARG A 243 11.953 -6.346 -11.809 1.00 98.06 C \\\\nATOM 1948 O ARG A 243 14.748 -5.576 -10.598 1.00 98.06 O \\\\nATOM 1949 CG ARG A 243 11.106 -6.643 -10.571 1.00 98.06 C \\\\nATOM 1950 CD ARG A 243 10.301 -7.925 -10.764 1.00 98.06 C \\\\nATOM 1951 NE ARG A 243 9.956 -8.477 -9.451 1.00 98.06 N \\\\nATOM 1952 NH1 ARG A 243 8.193 -9.836 -10.058 1.00 98.06 N \\\\nATOM 1953 NH2 ARG A 243 8.897 -9.730 -7.940 1.00 98.06 N \\\\nATOM 1954 CZ ARG A 243 9.014 -9.349 -9.171 1.00 98.06 C \\\\nATOM 1955 N VAL A 244 13.291 -4.378 -9.379 1.00 98.38 N \\\\nATOM 1956 CA VAL A 244 14.143 -4.200 -8.196 1.00 98.38 C \\\\nATOM 1957 C VAL A 244 13.391 -4.645 -6.941 1.00 98.38 C \\\\nATOM 1958 CB VAL A 244 14.626 -2.736 -8.101 1.00 98.38 C \\\\nATOM 1959 O VAL A 244 12.381 -4.055 -6.570 1.00 98.38 O \\\\nATOM 1960 CG1 VAL A 244 15.439 -2.476 -6.827 1.00 98.38 C \\\\nATOM 1961 CG2 VAL A 244 15.519 -2.366 -9.293 1.00 98.38 C \\\\nATOM 1962 N GLY A 245 13.918 -5.665 -6.260 1.00 96.94 N \\\\nATOM 1963 CA GLY A 245 13.327 -6.223 -5.041 1.00 96.94 C \\\\nATOM 1964 C GLY A 245 12.210 -7.251 -5.269 1.00 96.94 C \\\\nATOM 1965 O GLY A 245 11.853 -7.617 -6.394 1.00 96.94 O \\\\nATOM 1966 N GLU A 246 11.680 -7.746 -4.153 1.00 96.05 N \\\\nATOM 1967 CA GLU A 246 10.594 -8.728 -4.106 1.00 96.05 C \\\\nATOM 1968 C GLU A 246 9.227 -8.084 -4.399 1.00 96.05 C \\\\nATOM 1969 CB GLU A 246 10.600 -9.438 -2.742 1.00 96.05 C \\\\nATOM 1970 O GLU A 246 9.067 -6.864 -4.327 1.00 96.05 O \\\\nATOM 1971 CG GLU A 246 11.927 -10.178 -2.493 1.00 96.05 C \\\\nATOM 1972 CD GLU A 246 11.932 -10.976 -1.182 1.00 96.05 C \\\\nATOM 1973 OE1 GLU A 246 12.596 -12.035 -1.169 1.00 96.05 O \\\\nATOM 1974 OE2 GLU A 246 11.300 -10.506 -0.211 1.00 96.05 O \\\\nATOM 1975 N THR A 247 8.223 -8.900 -4.741 1.00 97.28 N \\\\nATOM 1976 CA THR A 247 6.836 -8.416 -4.842 1.00 97.28 C \\\\nATOM 1977 C THR A 247 6.261 -8.242 -3.439 1.00 97.28 C \\\\nATOM 1978 CB THR A 247 5.942 -9.364 -5.659 1.00 97.28 C \\\\nATOM 1979 O THR A 247 6.203 -9.197 -2.663 1.00 97.28 O \\\\nATOM 1980 CG2 THR A 247 4.483 -8.934 -5.724 1.00 97.28 C \\\\nATOM 1981 OG1 THR A 247 6.361 -9.404 -7.003 1.00 97.28 O \\\\nATOM 1982 N PHE A 248 5.779 -7.043 -3.130 1.00 97.00 N \\\\nATOM 1983 CA PHE A 248 5.022 -6.783 -1.912 1.00 97.00 C \\\\nATOM 1984 C PHE A 248 3.574 -7.265 -2.077 1.00 97.00 C \\\\nATOM 1985 CB PHE A 248 5.102 -5.290 -1.588 1.00 97.00 C \\\\nATOM 1986 O PHE A 248 2.968 -7.046 -3.124 1.00 97.00 O \\\\nATOM 1987 CG PHE A 248 4.498 -4.937 -0.248 1.00 97.00 C \\\\nATOM 1988 CD1 PHE A 248 3.108 -4.751 -0.124 1.00 97.00 C \\\\nATOM 1989 CD2 PHE A 248 5.327 -4.822 0.884 1.00 97.00 C \\\\nATOM 1990 CE1 PHE A 248 2.550 -4.462 1.132 1.00 97.00 C \\\\nATOM 1991 CE2 PHE A 248 4.771 -4.501 2.134 1.00 97.00 C \\\\nATOM 1992 CZ PHE A 248 3.383 -4.322 2.254 1.00 97.00 C \\\\nATOM 1993 N HIS A 249 2.996 -7.886 -1.048 1.00 97.02 N \\\\nATOM 1994 CA HIS A 249 1.628 -8.415 -1.075 1.00 97.02 C \\\\nATOM 1995 C HIS A 249 0.777 -7.718 -0.006 1.00 97.02 C \\\\nATOM 1996 CB HIS A 249 1.668 -9.938 -0.893 1.00 97.02 C \\\\nATOM 1997 O HIS A 249 1.065 -7.816 1.186 1.00 97.02 O \\\\nATOM 1998 CG HIS A 249 2.379 -10.664 -2.010 1.00 97.02 C \\\\nATOM 1999 CD2 HIS A 249 1.784 -11.303 -3.065 1.00 97.02 C \\\\nATOM 2000 ND1 HIS A 249 3.740 -10.819 -2.165 1.00 97.02 N \\\\nATOM 2001 CE1 HIS A 249 3.954 -11.537 -3.277 1.00 97.02 C \\\\nATOM 2002 NE2 HIS A 249 2.791 -11.844 -3.870 1.00 97.02 N \\\\nATOM 2003 N ALA A 250 -0.265 -6.997 -0.425 1.00 95.01 N \\\\nATOM 2004 CA ALA A 250 -1.051 -6.142 0.459 1.00 95.01 C \\\\nATOM 2005 C ALA A 250 -2.266 -6.885 1.031 1.00 95.01 C \\\\nATOM 2006 CB ALA A 250 -1.460 -4.890 -0.323 1.00 95.01 C \\\\nATOM 2007 O ALA A 250 -3.233 -7.147 0.317 1.00 95.01 O \\\\nATOM 2008 N SER A 251 -2.227 -7.219 2.324 1.00 91.07 N \\\\nATOM 2009 CA SER A 251 -3.373 -7.794 3.047 1.00 91.07 C \\\\nATOM 2010 C SER A 251 -4.229 -6.731 3.737 1.00 91.07 C \\\\nATOM 2011 CB SER A 251 -2.896 -8.827 4.069 1.00 91.07 C \\\\nATOM 2012 O SER A 251 -5.447 -6.868 3.805 1.00 91.07 O \\\\nATOM 2013 OG SER A 251 -1.964 -8.254 4.975 1.00 91.07 O \\\\nATOM 2014 N GLN A 252 -3.615 -5.649 4.226 1.00 90.73 N \\\\nATOM 2015 CA GLN A 252 -4.331 -4.580 4.924 1.00 90.73 C \\\\nATOM 2016 C GLN A 252 -5.089 -3.667 3.945 1.00 90.73 C \\\\nATOM 2017 CB GLN A 252 -3.369 -3.767 5.810 1.00 90.73 C \\\\nATOM 2018 O GLN A 252 -4.523 -3.317 2.904 1.00 90.73 O \\\\nATOM 2019 CG GLN A 252 -2.758 -4.604 6.947 1.00 90.73 C \\\\nATOM 2020 CD GLN A 252 -3.801 -5.213 7.884 1.00 90.73 C \\\\nATOM 2021 NE2 GLN A 252 -3.472 -6.274 8.586 1.00 90.73 N \\\\nATOM 2022 OE1 GLN A 252 -4.936 -4.780 7.987 1.00 90.73 O \\\\nATOM 2023 N PRO A 253 -6.313 -3.194 4.272 1.00 90.20 N \\\\nATOM 2024 CA PRO A 253 -7.105 -2.315 3.397 1.00 90.20 C \\\\nATOM 2025 C PRO A 253 -6.448 -0.966 3.070 1.00 90.20 C \\\\nATOM 2026 CB PRO A 253 -8.428 -2.075 4.136 1.00 90.20 C \\\\nATOM 2027 O PRO A 253 -6.895 -0.256 2.175 1.00 90.20 O \\\\nATOM 2028 CG PRO A 253 -8.556 -3.278 5.064 1.00 90.20 C \\\\nATOM 2029 CD PRO A 253 -7.107 -3.576 5.437 1.00 90.20 C \\\\nATOM 2030 N SER A 254 -5.403 -0.580 3.802 1.00 93.37 N \\\\nATOM 2031 CA SER A 254 -4.603 0.618 3.560 1.00 93.37 C \\\\nATOM 2032 C SER A 254 -3.127 0.267 3.695 1.00 93.37 C \\\\nATOM 2033 CB SER A 254 -5.004 1.713 4.557 1.00 93.37 C \\\\nATOM 2034 O SER A 254 -2.726 -0.324 4.692 1.00 93.37 O \\\\nATOM 2035 OG SER A 254 -4.131 2.832 4.511 1.00 93.37 O \\\\nATOM 2036 N MET A 255 -2.311 0.706 2.741 1.00 95.32 N \\\\nATOM 2037 CA MET A 255 -0.854 0.588 2.792 1.00 95.32 C \\\\nATOM 2038 C MET A 255 -0.169 1.840 2.233 1.00 95.32 C \\\\nATOM 2039 CB MET A 255 -0.395 -0.682 2.060 1.00 95.32 C \\\\nATOM 2040 O MET A 255 -0.796 2.671 1.576 1.00 95.32 O \\\\nATOM 2041 CG MET A 255 -0.550 -0.591 0.534 1.00 95.32 C \\\\nATOM 2042 SD MET A 255 0.361 -1.848 -0.389 1.00 95.32 S \\\\nATOM 2043 CE MET A 255 2.074 -1.433 0.046 1.00 95.32 C \\\\nATOM 2044 N THR A 256 1.135 1.974 2.461 1.00 97.98 N \\\\nATOM 2045 CA THR A 256 1.963 3.043 1.885 1.00 97.98 C \\\\nATOM 2046 C THR A 256 3.144 2.443 1.129 1.00 97.98 C \\\\nATOM 2047 CB THR A 256 2.449 4.016 2.971 1.00 97.98 C \\\\nATOM 2048 O THR A 256 3.807 1.546 1.639 1.00 97.98 O \\\\nATOM 2049 CG2 THR A 256 3.014 5.307 2.385 1.00 97.98 C \\\\nATOM 2050 OG1 THR A 256 1.371 4.392 3.804 1.00 97.98 O \\\\nATOM 2051 N VAL A 257 3.434 2.942 -0.070 1.00 98.59 N \\\\nATOM 2052 CA VAL A 257 4.696 2.681 -0.775 1.00 98.59 C \\\\nATOM 2053 C VAL A 257 5.546 3.939 -0.637 1.00 98.59 C \\\\nATOM 2054 CB VAL A 257 4.466 2.311 -2.252 1.00 98.59 C \\\\nATOM 2055 O VAL A 257 5.147 4.992 -1.136 1.00 98.59 O \\\\nATOM 2056 CG1 VAL A 257 5.791 1.898 -2.897 1.00 98.59 C \\\\nATOM 2057 CG2 VAL A 257 3.451 1.175 -2.436 1.00 98.59 C \\\\nATOM 2058 N ASP A 258 6.672 3.861 0.073 1.00 98.59 N \\\\nATOM 2059 CA ASP A 258 7.464 5.030 0.481 1.00 98.59 C \\\\nATOM 2060 C ASP A 258 8.975 4.871 0.236 1.00 98.59 C \\\\nATOM 2061 CB ASP A 258 7.095 5.455 1.918 1.00 98.59 C \\\\nATOM 2062 O ASP A 258 9.464 3.803 -0.117 1.00 98.59 O \\\\nATOM 2063 CG ASP A 258 7.618 4.573 3.055 1.00 98.59 C \\\\nATOM 2064 OD1 ASP A 258 8.842 4.336 3.109 1.00 98.59 O \\\\nATOM 2065 OD2 ASP A 258 6.856 4.304 4.015 1.00 98.59 O \\\\nATOM 2066 N GLY A 259 9.722 5.970 0.356 1.00 98.35 N \\\\nATOM 2067 CA GLY A 259 11.163 6.037 0.098 1.00 98.35 C \\\\nATOM 2068 C GLY A 259 12.046 5.753 1.317 1.00 98.35 C \\\\nATOM 2069 O GLY A 259 13.248 6.001 1.246 1.00 98.35 O \\\\nATOM 2070 N PHE A 260 11.484 5.287 2.436 1.00 97.98 N \\\\nATOM 2071 CA PHE A 260 12.225 5.007 3.667 1.00 97.98 C \\\\nATOM 2072 C PHE A 260 12.692 3.537 3.722 1.00 97.98 C \\\\nATOM 2073 CB PHE A 260 11.377 5.441 4.874 1.00 97.98 C \\\\nATOM 2074 O PHE A 260 12.752 2.855 2.700 1.00 97.98 O \\\\nATOM 2075 CG PHE A 260 10.859 6.873 4.828 1.00 97.98 C \\\\nATOM 2076 CD1 PHE A 260 11.765 7.951 4.833 1.00 97.98 C \\\\nATOM 2077 CD2 PHE A 260 9.476 7.137 4.793 1.00 97.98 C \\\\nATOM 2078 CE1 PHE A 260 11.293 9.276 4.802 1.00 97.98 C \\\\nATOM 2079 CE2 PHE A 260 9.002 8.460 4.769 1.00 97.98 C \\\\nATOM 2080 CZ PHE A 260 9.911 9.533 4.771 1.00 97.98 C \\\\nATOM 2081 N THR A 261 13.114 3.057 4.898 1.00 97.45 N \\\\nATOM 2082 CA THR A 261 13.944 1.843 5.042 1.00 97.45 C \\\\nATOM 2083 C THR A 261 13.457 0.865 6.124 1.00 97.45 C \\\\nATOM 2084 CB THR A 261 15.413 2.228 5.303 1.00 97.45 C \\\\nATOM 2085 O THR A 261 14.274 0.237 6.791 1.00 97.45 O \\\\nATOM 2086 CG2 THR A 261 16.016 3.142 4.236 1.00 97.45 C \\\\nATOM 2087 OG1 THR A 261 15.497 2.905 6.536 1.00 97.45 O \\\\nATOM 2088 N ASP A 262 12.148 0.768 6.359 1.00 95.17 N \\\\nATOM 2089 CA ASP A 262 11.557 -0.171 7.330 1.00 95.17 C \\\\nATOM 2090 C ASP A 262 11.226 -1.508 6.631 1.00 95.17 C \\\\nATOM 2091 CB ASP A 262 10.329 0.514 7.949 1.00 95.17 C \\\\nATOM 2092 O ASP A 262 10.349 -1.517 5.765 1.00 95.17 O \\\\nATOM 2093 CG ASP A 262 9.506 -0.309 8.941 1.00 95.17 C \\\\nATOM 2094 OD1 ASP A 262 9.875 -1.471 9.213 1.00 95.17 O \\\\nATOM 2095 OD2 ASP A 262 8.501 0.287 9.413 1.00 95.17 O \\\\nATOM 2096 N PRO A 263 11.930 -2.617 6.940 1.00 92.14 N \\\\nATOM 2097 CA PRO A 263 11.783 -3.882 6.221 1.00 92.14 C \\\\nATOM 2098 C PRO A 263 10.658 -4.780 6.757 1.00 92.14 C \\\\nATOM 2099 CB PRO A 263 13.144 -4.569 6.390 1.00 92.14 C \\\\nATOM 2100 O PRO A 263 10.397 -5.820 6.161 1.00 92.14 O \\\\nATOM 2101 CG PRO A 263 13.546 -4.156 7.805 1.00 92.14 C \\\\nATOM 2102 CD PRO A 263 13.025 -2.721 7.898 1.00 92.14 C \\\\nATOM 2103 N SER A 264 10.043 -4.456 7.901 1.00 89.29 N \\\\nATOM 2104 CA SER A 264 9.228 -5.412 8.675 1.00 89.29 C \\\\nATOM 2105 C SER A 264 7.748 -5.047 8.797 1.00 89.29 C \\\\nATOM 2106 CB SER A 264 9.852 -5.611 10.058 1.00 89.29 C \\\\nATOM 2107 O SER A 264 6.975 -5.786 9.409 1.00 89.29 O \\\\nATOM 2108 OG SER A 264 9.904 -4.393 10.775 1.00 89.29 O \\\\nATOM 2109 N ASN A 265 7.334 -3.917 8.228 1.00 88.56 N \\\\nATOM 2110 CA ASN A 265 5.992 -3.379 8.391 1.00 88.56 C \\\\nATOM 2111 C ASN A 265 5.062 -3.788 7.234 1.00 88.56 C \\\\nATOM 2112 CB ASN A 265 6.154 -1.869 8.581 1.00 88.56 C \\\\nATOM 2113 O ASN A 265 5.209 -3.325 6.106 1.00 88.56 O \\\\nATOM 2114 CG ASN A 265 4.866 -1.162 8.931 1.00 88.56 C \\\\nATOM 2115 ND2 ASN A 265 4.961 -0.102 9.695 1.00 88.56 N \\\\nATOM 2116 OD1 ASN A 265 3.773 -1.539 8.554 1.00 88.56 O \\\\nATOM 2117 N SER A 266 4.054 -4.613 7.527 1.00 89.15 N \\\\nATOM 2118 CA SER A 266 3.077 -5.123 6.550 1.00 89.15 C \\\\nATOM 2119 C SER A 266 2.102 -4.074 5.990 1.00 89.15 C \\\\nATOM 2120 CB SER A 266 2.299 -6.287 7.168 1.00 89.15 C \\\\nATOM 2121 O SER A 266 1.358 -4.377 5.060 1.00 89.15 O \\\\nATOM 2122 OG SER A 266 1.744 -5.908 8.415 1.00 89.15 O \\\\nATOM 2123 N GLU A 267 2.116 -2.839 6.498 1.00 92.42 N \\\\nATOM 2124 CA GLU A 267 1.410 -1.688 5.916 1.00 92.42 C \\\\nATOM 2125 C GLU A 267 2.337 -0.796 5.064 1.00 92.42 C \\\\nATOM 2126 CB GLU A 267 0.740 -0.852 7.025 1.00 92.42 C \\\\nATOM 2127 O GLU A 267 1.879 0.211 4.517 1.00 92.42 O \\\\nATOM 2128 CG GLU A 267 -0.372 -1.588 7.791 1.00 92.42 C \\\\nATOM 2129 CD GLU A 267 -0.968 -0.749 8.942 1.00 92.42 C \\\\nATOM 2130 OE1 GLU A 267 -1.641 -1.347 9.812 1.00 92.42 O \\\\nATOM 2131 OE2 GLU A 267 -0.756 0.490 8.978 1.00 92.42 O \\\\nATOM 2132 N ARG A 268 3.642 -1.106 4.951 1.00 96.71 N \\\\nATOM 2133 CA ARG A 268 4.633 -0.235 4.295 1.00 96.71 C \\\\nATOM 2134 C ARG A 268 5.581 -0.984 3.360 1.00 96.71 C \\\\nATOM 2135 CB ARG A 268 5.451 0.535 5.336 1.00 96.71 C \\\\nATOM 2136 O ARG A 268 6.459 -1.720 3.799 1.00 96.71 O \\\\nATOM 2137 CG ARG A 268 4.598 1.470 6.205 1.00 96.71 C \\\\nATOM 2138 CD ARG A 268 5.471 2.197 7.229 1.00 96.71 C \\\\nATOM 2139 NE ARG A 268 6.461 3.067 6.578 1.00 96.71 N \\\\nATOM 2140 NH1 ARG A 268 8.178 2.875 8.116 1.00 96.71 N \\\\nATOM 2141 NH2 ARG A 268 8.428 4.071 6.252 1.00 96.71 N \\\\nATOM 2142 CZ ARG A 268 7.677 3.330 7.000 1.00 96.71 C \\\\nATOM 2143 N PHE A 269 5.496 -0.685 2.067 1.00 97.68 N \\\\nATOM 2144 CA PHE A 269 6.505 -1.092 1.095 1.00 97.68 C \\\\nATOM 2145 C PHE A 269 7.594 -0.013 0.995 1.00 97.68 C \\\\nATOM 2146 CB PHE A 269 5.841 -1.419 -0.246 1.00 97.68 C \\\\nATOM 2147 O PHE A 269 7.465 0.977 0.272 1.00 97.68 O \\\\nATOM 2148 CG PHE A 269 6.732 -2.035 -1.317 1.00 97.68 C \\\\nATOM 2149 CD1 PHE A 269 6.290 -2.019 -2.654 1.00 97.68 C \\\\nATOM 2150 CD2 PHE A 269 7.951 -2.678 -1.003 1.00 97.68 C \\\\nATOM 2151 CE1 PHE A 269 7.051 -2.635 -3.663 1.00 97.68 C \\\\nATOM 2152 CE2 PHE A 269 8.709 -3.292 -2.014 1.00 97.68 C \\\\nATOM 2153 CZ PHE A 269 8.260 -3.274 -3.343 1.00 97.68 C \\\\nATOM 2154 N CYS A 270 8.660 -0.192 1.772 1.00 97.96 N \\\\nATOM 2155 CA CYS A 270 9.772 0.749 1.880 1.00 97.96 C \\\\nATOM 2156 C CYS A 270 10.801 0.547 0.756 1.00 97.96 C \\\\nATOM 2157 CB CYS A 270 10.393 0.560 3.264 1.00 97.96 C \\\\nATOM 2158 O CYS A 270 11.706 -0.278 0.855 1.00 97.96 O \\\\nATOM 2159 SG CYS A 270 9.279 1.227 4.523 1.00 97.96 S \\\\nATOM 2160 N LEU A 271 10.700 1.336 -0.313 1.00 98.37 N \\\\nATOM 2161 CA LEU A 271 11.570 1.252 -1.490 1.00 98.37 C \\\\nATOM 2162 C LEU A 271 13.017 1.677 -1.204 1.00 98.37 C \\\\nATOM 2163 CB LEU A 271 10.985 2.129 -2.613 1.00 98.37 C \\\\nATOM 2164 O LEU A 271 13.931 1.282 -1.934 1.00 98.37 O \\\\nATOM 2165 CG LEU A 271 9.530 1.812 -3.013 1.00 98.37 C \\\\nATOM 2166 CD1 LEU A 271 9.126 2.737 -4.161 1.00 98.37 C \\\\nATOM 2167 CD2 LEU A 271 9.361 0.360 -3.452 1.00 98.37 C \\\\nATOM 2168 N GLY A 272 13.246 2.484 -0.163 1.00 97.79 N \\\\nATOM 2169 CA GLY A 272 14.545 3.069 0.179 1.00 97.79 C \\\\nATOM 2170 C GLY A 272 15.617 2.040 0.545 1.00 97.79 C \\\\nATOM 2171 O GLY A 272 16.781 2.254 0.210 1.00 97.79 O \\\\nATOM 2172 N LEU A 273 15.226 0.906 1.141 1.00 96.65 N \\\\nATOM 2173 CA LEU A 273 16.139 -0.196 1.493 1.00 96.65 C \\\\nATOM 2174 C LEU A 273 16.521 -1.096 0.307 1.00 96.65 C \\\\nATOM 2175 CB LEU A 273 15.547 -1.007 2.665 1.00 96.65 C \\\\nATOM 2176 O LEU A 273 17.466 -1.872 0.412 1.00 96.65 O \\\\nATOM 2177 CG LEU A 273 14.300 -1.851 2.311 1.00 96.65 C \\\\nATOM 2178 CD1 LEU A 273 14.642 -3.321 2.064 1.00 96.65 C \\\\nATOM 2179 CD2 LEU A 273 13.283 -1.793 3.449 1.00 96.65 C \\\\nATOM 2180 N LEU A 274 15.799 -1.014 -0.815 1.00 97.53 N \\\\nATOM 2181 CA LEU A 274 16.035 -1.883 -1.966 1.00 97.53 C \\\\nATOM 2182 C LEU A 274 17.331 -1.493 -2.693 1.00 97.53 C \\\\nATOM 2183 CB LEU A 274 14.819 -1.875 -2.911 1.00 97.53 C \\\\nATOM 2184 O LEU A 274 17.503 -0.348 -3.127 1.00 97.53 O \\\\nATOM 2185 CG LEU A 274 13.475 -2.263 -2.261 1.00 97.53 C \\\\nATOM 2186 CD1 LEU A 274 12.360 -2.159 -3.298 1.00 97.53 C \\\\nATOM 2187 CD2 LEU A 274 13.486 -3.689 -1.708 1.00 97.53 C \\\\nATOM 2188 N SER A 275 18.231 -2.457 -2.866 1.00 97.29 N \\\\nATOM 2189 CA SER A 275 19.495 -2.297 -3.593 1.00 97.29 C \\\\nATOM 2190 C SER A 275 19.337 -2.595 -5.084 1.00 97.29 C \\\\nATOM 2191 CB SER A 275 20.570 -3.202 -2.989 1.00 97.29 C \\\\nATOM 2192 O SER A 275 18.613 -3.508 -5.468 1.00 97.29 O \\\\nATOM 2193 OG SER A 275 20.889 -2.729 -1.698 1.00 97.29 O \\\\nATOM 2194 N ASN A 276 20.062 -1.854 -5.922 1.00 97.60 N \\\\nATOM 2195 CA ASN A 276 20.222 -2.133 -7.348 1.00 97.60 C \\\\nATOM 2196 C ASN A 276 21.642 -1.728 -7.766 1.00 97.60 C \\\\nATOM 2197 CB ASN A 276 19.150 -1.372 -8.147 1.00 97.60 C \\\\nATOM 2198 O ASN A 276 22.036 -0.583 -7.550 1.00 97.60 O \\\\nATOM 2199 CG ASN A 276 19.281 -1.562 -9.649 1.00 97.60 C \\\\nATOM 2200 ND2 ASN A 276 18.599 -0.758 -10.423 1.00 97.60 N \\\\nATOM 2201 OD1 ASN A 276 20.009 -2.418 -10.132 1.00 97.60 O \\\\nATOM 2202 N VAL A 277 22.401 -2.660 -8.347 1.00 97.53 N \\\\nATOM 2203 CA VAL A 277 23.790 -2.432 -8.788 1.00 97.53 C \\\\nATOM 2204 C VAL A 277 23.883 -1.607 -10.075 1.00 97.53 C \\\\nATOM 2205 CB VAL A 277 24.560 -3.758 -8.942 1.00 97.53 C \\\\nATOM 2206 O VAL A 277 24.888 -0.944 -10.296 1.00 97.53 O \\\\nATOM 2207 CG1 VAL A 277 24.703 -4.463 -7.586 1.00 97.53 C \\\\nATOM 2208 CG2 VAL A 277 23.902 -4.734 -9.928 1.00 97.53 C \\\\nATOM 2209 N ASN A 278 22.820 -1.582 -10.886 1.00 97.11 N \\\\nATOM 2210 CA ASN A 278 22.754 -0.822 -12.142 1.00 97.11 C \\\\nATOM 2211 C ASN A 278 22.172 0.592 -11.951 1.00 97.11 C \\\\nATOM 2212 CB ASN A 278 21.926 -1.625 -13.154 1.00 97.11 C \\\\nATOM 2213 O ASN A 278 21.821 1.276 -12.916 1.00 97.11 O \\\\nATOM 2214 CG ASN A 278 22.476 -3.007 -13.444 1.00 97.11 C \\\\nATOM 2215 ND2 ASN A 278 21.611 -3.949 -13.725 1.00 97.11 N \\\\nATOM 2216 OD1 ASN A 278 23.666 -3.263 -13.422 1.00 97.11 O \\\\nATOM 2217 N ARG A 279 21.996 1.027 -10.698 1.00 97.96 N \\\\nATOM 2218 CA ARG A 279 21.340 2.290 -10.366 1.00 97.96 C \\\\nATOM 2219 C ARG A 279 22.193 3.478 -10.809 1.00 97.96 C \\\\nATOM 2220 CB ARG A 279 21.060 2.312 -8.863 1.00 97.96 C \\\\nATOM 2221 O ARG A 279 23.320 3.644 -10.360 1.00 97.96 O \\\\nATOM 2222 CG ARG A 279 20.244 3.545 -8.475 1.00 97.96 C \\\\nATOM 2223 CD ARG A 279 19.859 3.495 -6.999 1.00 97.96 C \\\\nATOM 2224 NE ARG A 279 18.879 2.424 -6.746 1.00 97.96 N \\\\nATOM 2225 NH1 ARG A 279 19.536 1.773 -4.627 1.00 97.96 N \\\\nATOM 2226 NH2 ARG A 279 17.786 0.836 -5.597 1.00 97.96 N \\\\nATOM 2227 CZ ARG A 279 18.752 1.686 -5.665 1.00 97.96 C \\\\nATOM 2228 N ASN A 280 21.625 4.343 -11.646 1.00 98.01 N \\\\nATOM 2229 CA ASN A 280 22.284 5.575 -12.082 1.00 98.01 C \\\\nATOM 2230 C ASN A 280 21.891 6.792 -11.219 1.00 98.01 C \\\\nATOM 2231 CB ASN A 280 22.066 5.759 -13.597 1.00 98.01 C \\\\nATOM 2232 O ASN A 280 20.905 6.771 -10.476 1.00 98.01 O \\\\nATOM 2233 CG ASN A 280 20.659 6.171 -13.997 1.00 98.01 C \\\\nATOM 2234 ND2 ASN A 280 20.158 5.652 -15.090 1.00 98.01 N \\\\nATOM 2235 OD1 ASN A 280 20.010 6.991 -13.367 1.00 98.01 O \\\\nATOM 2236 N ALA A 281 22.632 7.894 -11.368 1.00 98.22 N \\\\nATOM 2237 CA ALA A 281 22.433 9.122 -10.594 1.00 98.22 C \\\\nATOM 2238 C ALA A 281 21.018 9.732 -10.717 1.00 98.22 C \\\\nATOM 2239 CB ALA A 281 23.501 10.127 -11.044 1.00 98.22 C \\\\nATOM 2240 O ALA A 281 20.518 10.328 -9.762 1.00 98.22 O \\\\nATOM 2241 N ALA A 282 20.339 9.570 -11.860 1.00 97.51 N \\\\nATOM 2242 CA ALA A 282 18.974 10.067 -12.047 1.00 97.51 C \\\\nATOM 2243 C ALA A 282 17.950 9.249 -11.239 1.00 97.51 C \\\\nATOM 2244 CB ALA A 282 18.643 10.075 -13.544 1.00 97.51 C \\\\nATOM 2245 O ALA A 282 16.999 9.815 -10.689 1.00 97.51 O \\\\nATOM 2246 N VAL A 283 18.165 7.934 -11.122 1.00 98.47 N \\\\nATOM 2247 CA VAL A 283 17.389 7.047 -10.245 1.00 98.47 C \\\\nATOM 2248 C VAL A 283 17.664 7.375 -8.778 1.00 98.47 C \\\\nATOM 2249 CB VAL A 283 17.676 5.565 -10.555 1.00 98.47 C \\\\nATOM 2250 O VAL A 283 16.717 7.591 -8.027 1.00 98.47 O \\\\nATOM 2251 CG1 VAL A 283 16.889 4.649 -9.617 1.00 98.47 C \\\\nATOM 2252 CG2 VAL A 283 17.304 5.177 -11.993 1.00 98.47 C \\\\nATOM 2253 N GLU A 284 18.928 7.516 -8.364 1.00 98.10 N \\\\nATOM 2254 CA GLU A 284 19.264 7.908 -6.985 1.00 98.10 C \\\\nATOM 2255 C GLU A 284 18.616 9.230 -6.565 1.00 98.10 C \\\\nATOM 2256 CB GLU A 284 20.767 8.100 -6.802 1.00 98.10 C \\\\nATOM 2257 O GLU A 284 18.015 9.320 -5.492 1.00 98.10 O \\\\nATOM 2258 CG GLU A 284 21.591 6.819 -6.912 1.00 98.10 C \\\\nATOM 2259 CD GLU A 284 23.012 7.033 -6.376 1.00 98.10 C \\\\nATOM 2260 OE1 GLU A 284 23.693 6.005 -6.206 1.00 98.10 O \\\\nATOM 2261 OE2 GLU A 284 23.355 8.200 -6.052 1.00 98.10 O \\\\nATOM 2262 N LEU A 285 18.712 10.256 -7.416 1.00 97.88 N \\\\nATOM 2263 CA LEU A 285 18.103 11.557 -7.160 1.00 97.88 C \\\\nATOM 2264 C LEU A 285 16.577 11.448 -7.064 1.00 97.88 C \\\\nATOM 2265 CB LEU A 285 18.540 12.528 -8.271 1.00 97.88 C \\\\nATOM 2266 O LEU A 285 15.972 12.091 -6.209 1.00 97.88 O \\\\nATOM 2267 CG LEU A 285 18.038 13.971 -8.080 1.00 97.88 C \\\\nATOM 2268 CD1 LEU A 285 18.614 14.620 -6.819 1.00 97.88 C \\\\nATOM 2269 CD2 LEU A 285 18.441 14.815 -9.287 1.00 97.88 C \\\\nATOM 2270 N THR A 286 15.953 10.614 -7.899 1.00 98.50 N \\\\nATOM 2271 CA THR A 286 14.501 10.386 -7.877 1.00 98.50 C \\\\nATOM 2272 C THR A 286 14.064 9.674 -6.596 1.00 98.50 C \\\\nATOM 2273 CB THR A 286 14.054 9.625 -9.133 1.00 98.50 C \\\\nATOM 2274 O THR A 286 13.122 10.129 -5.949 1.00 98.50 O \\\\nATOM 2275 CG2 THR A 286 12.547 9.397 -9.178 1.00 98.50 C \\\\nATOM 2276 OG1 THR A 286 14.390 10.398 -10.269 1.00 98.50 O \\\\nATOM 2277 N ARG A 287 14.794 8.638 -6.154 1.00 98.55 N \\\\nATOM 2278 CA ARG A 287 14.523 7.904 -4.901 1.00 98.55 C \\\\nATOM 2279 C ARG A 287 14.482 8.822 -3.678 1.00 98.55 C \\\\nATOM 2280 CB ARG A 287 15.564 6.790 -4.704 1.00 98.55 C \\\\nATOM 2281 O ARG A 287 13.576 8.694 -2.859 1.00 98.55 O \\\\nATOM 2282 CG ARG A 287 15.359 5.631 -5.690 1.00 98.55 C \\\\nATOM 2283 CD ARG A 287 16.531 4.646 -5.688 1.00 98.55 C \\\\nATOM 2284 NE ARG A 287 16.726 3.989 -4.382 1.00 98.55 N \\\\nATOM 2285 NH1 ARG A 287 15.047 2.408 -4.548 1.00 98.55 N \\\\nATOM 2286 NH2 ARG A 287 16.237 2.559 -2.695 1.00 98.55 N \\\\nATOM 2287 CZ ARG A 287 16.004 2.997 -3.893 1.00 98.55 C \\\\nATOM 2288 N ARG A 288 15.396 9.799 -3.592 1.00 98.14 N \\\\nATOM 2289 CA ARG A 288 15.428 10.806 -2.505 1.00 98.14 C \\\\nATOM 2290 C ARG A 288 14.143 11.644 -2.420 1.00 98.14 C \\\\nATOM 2291 CB ARG A 288 16.650 11.731 -2.667 1.00 98.14 C \\\\nATOM 2292 O ARG A 288 13.778 12.070 -1.332 1.00 98.14 O \\\\nATOM 2293 CG ARG A 288 17.993 11.000 -2.498 1.00 98.14 C \\\\nATOM 2294 CD ARG A 288 19.181 11.901 -2.874 1.00 98.14 C \\\\nATOM 2295 NE ARG A 288 20.398 11.107 -3.150 1.00 98.14 N \\\\nATOM 2296 NH1 ARG A 288 21.675 12.765 -4.097 1.00 98.14 N \\\\nATOM 2297 NH2 ARG A 288 22.412 10.662 -4.146 1.00 98.14 N \\\\nATOM 2298 CZ ARG A 288 21.488 11.511 -3.787 1.00 98.14 C \\\\nATOM 2299 N HIS A 289 13.449 11.845 -3.541 1.00 98.35 N \\\\nATOM 2300 CA HIS A 289 12.217 12.635 -3.628 1.00 98.35 C \\\\nATOM 2301 C HIS A 289 10.932 11.800 -3.487 1.00 98.35 C \\\\nATOM 2302 CB HIS A 289 12.228 13.443 -4.933 1.00 98.35 C \\\\nATOM 2303 O HIS A 289 9.845 12.371 -3.441 1.00 98.35 O \\\\nATOM 2304 CG HIS A 289 13.279 14.519 -4.971 1.00 98.35 C \\\\nATOM 2305 CD2 HIS A 289 13.114 15.837 -4.644 1.00 98.35 C \\\\nATOM 2306 ND1 HIS A 289 14.587 14.359 -5.363 1.00 98.35 N \\\\nATOM 2307 CE1 HIS A 289 15.198 15.549 -5.271 1.00 98.35 C \\\\nATOM 2308 NE2 HIS A 289 14.339 16.483 -4.845 1.00 98.35 N \\\\nATOM 2309 N ILE A 290 11.017 10.466 -3.369 1.00 98.63 N \\\\nATOM 2310 CA ILE A 290 9.841 9.639 -3.050 1.00 98.63 C \\\\nATOM 2311 C ILE A 290 9.306 10.043 -1.671 1.00 98.63 C \\\\nATOM 2312 CB ILE A 290 10.157 8.125 -3.141 1.00 98.63 C \\\\nATOM 2313 O ILE A 290 8.115 10.314 -1.533 1.00 98.63 O \\\\nATOM 2314 CG1 ILE A 290 10.603 7.762 -4.577 1.00 98.63 C \\\\nATOM 2315 CG2 ILE A 290 8.930 7.285 -2.733 1.00 98.63 C \\\\nATOM 2316 CD1 ILE A 290 11.006 6.296 -4.777 1.00 98.63 C \\\\nATOM 2317 N GLY A 291 10.179 10.159 -0.662 1.00 97.93 N \\\\nATOM 2318 CA GLY A 291 9.796 10.581 0.688 1.00 97.93 C \\\\nATOM 2319 C GLY A 291 8.689 9.692 1.258 1.00 97.93 C \\\\nATOM 2320 O GLY A 291 8.837 8.476 1.311 1.00 97.93 O \\\\nATOM 2321 N ARG A 292 7.549 10.284 1.631 1.00 97.98 N \\\\nATOM 2322 CA ARG A 292 6.356 9.552 2.107 1.00 97.98 C \\\\nATOM 2323 C ARG A 292 5.579 8.813 1.001 1.00 97.98 C \\\\nATOM 2324 CB ARG A 292 5.429 10.523 2.843 1.00 97.98 C \\\\nATOM 2325 O ARG A 292 4.648 8.084 1.323 1.00 97.98 O \\\\nATOM 2326 CG ARG A 292 6.043 11.155 4.102 1.00 97.98 C \\\\nATOM 2327 CD ARG A 292 5.155 12.291 4.625 1.00 97.98 C \\\\nATOM 2328 NE ARG A 292 3.816 11.807 5.025 1.00 97.98 N \\\\nATOM 2329 NH1 ARG A 292 2.560 13.478 4.052 1.00 97.98 N \\\\nATOM 2330 NH2 ARG A 292 1.550 11.850 5.190 1.00 97.98 N \\\\nATOM 2331 CZ ARG A 292 2.657 12.386 4.757 1.00 97.98 C \\\\nATOM 2332 N GLY A 293 5.940 9.013 -0.267 1.00 98.48 N \\\\nATOM 2333 CA GLY A 293 5.458 8.255 -1.421 1.00 98.48 C \\\\nATOM 2334 C GLY A 293 3.948 8.325 -1.660 1.00 98.48 C \\\\nATOM 2335 O GLY A 293 3.371 9.413 -1.711 1.00 98.48 O \\\\nATOM 2336 N VAL A 294 3.316 7.167 -1.851 1.00 98.76 N \\\\nATOM 2337 CA VAL A 294 1.883 7.027 -2.148 1.00 98.76 C \\\\nATOM 2338 C VAL A 294 1.199 6.162 -1.095 1.00 98.76 C \\\\nATOM 2339 CB VAL A 294 1.649 6.501 -3.583 1.00 98.76 C \\\\nATOM 2340 O VAL A 294 1.681 5.080 -0.764 1.00 98.76 O \\\\nATOM 2341 CG1 VAL A 294 2.258 5.122 -3.865 1.00 98.76 C \\\\nATOM 2342 CG2 VAL A 294 0.160 6.438 -3.941 1.00 98.76 C \\\\nATOM 2343 N ARG A 295 0.049 6.616 -0.588 1.00 98.09 N \\\\nATOM 2344 CA ARG A 295 -0.880 5.762 0.159 1.00 98.09 C \\\\nATOM 2345 C ARG A 295 -1.883 5.153 -0.811 1.00 98.09 C \\\\nATOM 2346 CB ARG A 295 -1.528 6.533 1.317 1.00 98.09 C \\\\nATOM 2347 O ARG A 295 -2.517 5.875 -1.576 1.00 98.09 O \\\\nATOM 2348 CG ARG A 295 -2.630 5.709 1.999 1.00 98.09 C \\\\nATOM 2349 CD ARG A 295 -3.123 6.304 3.319 1.00 98.09 C \\\\nATOM 2350 NE ARG A 295 -3.835 7.594 3.177 1.00 98.09 N \\\\nATOM 2351 NH1 ARG A 295 -4.351 7.823 5.400 1.00 98.09 N \\\\nATOM 2352 NH2 ARG A 295 -4.968 9.401 4.026 1.00 98.09 N \\\\nATOM 2353 CZ ARG A 295 -4.365 8.267 4.180 1.00 98.09 C \\\\nATOM 2354 N LEU A 296 -2.036 3.839 -0.738 1.00 98.08 N \\\\nATOM 2355 CA LEU A 296 -3.010 3.062 -1.490 1.00 98.08 C \\\\nATOM 2356 C LEU A 296 -4.043 2.516 -0.509 1.00 98.08 C \\\\nATOM 2357 CB LEU A 296 -2.294 1.924 -2.231 1.00 98.08 C \\\\nATOM 2358 O LEU A 296 -3.667 2.012 0.551 1.00 98.08 O \\\\nATOM 2359 CG LEU A 296 -1.248 2.381 -3.261 1.00 98.08 C \\\\nATOM 2360 CD1 LEU A 296 -0.411 1.178 -3.685 1.00 98.08 C \\\\nATOM 2361 CD2 LEU A 296 -1.904 3.007 -4.492 1.00 98.08 C \\\\nATOM 2362 N TYR A 297 -5.329 2.623 -0.832 1.00 95.51 N \\\\nATOM 2363 CA TYR A 297 -6.385 2.059 0.007 1.00 95.51 C \\\\nATOM 2364 C TYR A 297 -7.529 1.468 -0.814 1.00 95.51 C \\\\nATOM 2365 CB TYR A 297 -6.864 3.077 1.057 1.00 95.51 C \\\\nATOM 2366 O TYR A 297 -7.959 2.065 -1.801 1.00 95.51 O \\\\nATOM 2367 CG TYR A 297 -7.340 4.429 0.545 1.00 95.51 C \\\\nATOM 2368 CD1 TYR A 297 -6.414 5.466 0.324 1.00 95.51 C \\\\nATOM 2369 CD2 TYR A 297 -8.708 4.666 0.320 1.00 95.51 C \\\\nATOM 2370 CE1 TYR A 297 -6.849 6.736 -0.100 1.00 95.51 C \\\\nATOM 2371 CE2 TYR A 297 -9.157 5.940 -0.083 1.00 95.51 C \\\\nATOM 2372 OH TYR A 297 -8.632 8.188 -0.768 1.00 95.51 O \\\\nATOM 2373 CZ TYR A 297 -8.223 6.975 -0.311 1.00 95.51 C \\\\nATOM 2374 N TYR A 298 -8.002 0.301 -0.375 1.00 94.74 N \\\\nATOM 2375 CA TYR A 298 -9.119 -0.454 -0.933 1.00 94.74 C \\\\nATOM 2376 C TYR A 298 -10.305 -0.400 0.031 1.00 94.74 C \\\\nATOM 2377 CB TYR A 298 -8.687 -1.901 -1.202 1.00 94.74 C \\\\nATOM 2378 O TYR A 298 -10.216 -0.871 1.165 1.00 94.74 O \\\\nATOM 2379 CG TYR A 298 -9.816 -2.794 -1.687 1.00 94.74 C \\\\nATOM 2380 CD1 TYR A 298 -10.159 -3.964 -0.979 1.00 94.74 C \\\\nATOM 2381 CD2 TYR A 298 -10.533 -2.448 -2.849 1.00 94.74 C \\\\nATOM 2382 CE1 TYR A 298 -11.210 -4.787 -1.436 1.00 94.74 C \\\\nATOM 2383 CE2 TYR A 298 -11.572 -3.276 -3.314 1.00 94.74 C \\\\nATOM 2384 OH TYR A 298 -12.949 -5.212 -3.055 1.00 94.74 O \\\\nATOM 2385 CZ TYR A 298 -11.919 -4.446 -2.607 1.00 94.74 C \\\\nATOM 2386 N ILE A 299 -11.394 0.244 -0.388 1.00 91.25 N \\\\nATOM 2387 CA ILE A 299 -12.558 0.535 0.455 1.00 91.25 C \\\\nATOM 2388 C ILE A 299 -13.815 0.469 -0.405 1.00 91.25 C \\\\nATOM 2389 CB ILE A 299 -12.423 1.927 1.118 1.00 91.25 C \\\\nATOM 2390 O ILE A 299 -13.893 1.129 -1.436 1.00 91.25 O \\\\nATOM 2391 CG1 ILE A 299 -11.142 1.993 1.981 1.00 91.25 C \\\\nATOM 2392 CG2 ILE A 299 -13.670 2.255 1.966 1.00 91.25 C \\\\nATOM 2393 CD1 ILE A 299 -10.920 3.332 2.662 1.00 91.25 C \\\\nATOM 2394 N GLY A 300 -14.817 -0.298 0.027 1.00 87.74 N \\\\nATOM 2395 CA GLY A 300 -16.122 -0.324 -0.635 1.00 87.74 C \\\\nATOM 2396 C GLY A 300 -16.095 -0.843 -2.079 1.00 87.74 C \\\\nATOM 2397 O GLY A 300 -16.918 -0.420 -2.883 1.00 87.74 O \\\\nATOM 2398 N GLY A 301 -15.134 -1.703 -2.439 1.00 92.50 N \\\\nATOM 2399 CA GLY A 301 -14.932 -2.138 -3.827 1.00 92.50 C \\\\nATOM 2400 C GLY A 301 -14.189 -1.123 -4.709 1.00 92.50 C \\\\nATOM 2401 O GLY A 301 -14.130 -1.302 -5.923 1.00 92.50 O \\\\nATOM 2402 N GLU A 302 -13.621 -0.061 -4.133 1.00 96.35 N \\\\nATOM 2403 CA GLU A 302 -12.888 0.985 -4.850 1.00 96.35 C \\\\nATOM 2404 C GLU A 302 -11.437 1.070 -4.369 1.00 96.35 C \\\\nATOM 2405 CB GLU A 302 -13.577 2.348 -4.682 1.00 96.35 C \\\\nATOM 2406 O GLU A 302 -11.167 0.962 -3.172 1.00 96.35 O \\\\nATOM 2407 CG GLU A 302 -15.088 2.312 -4.939 1.00 96.35 C \\\\nATOM 2408 CD GLU A 302 -15.652 3.709 -5.205 1.00 96.35 C \\\\nATOM 2409 OE1 GLU A 302 -16.276 3.889 -6.275 1.00 96.35 O \\\\nATOM 2410 OE2 GLU A 302 -15.407 4.677 -4.447 1.00 96.35 O \\\\nATOM 2411 N VAL A 303 -10.497 1.306 -5.288 1.00 97.65 N \\\\nATOM 2412 CA VAL A 303 -9.086 1.555 -4.958 1.00 97.65 C \\\\nATOM 2413 C VAL A 303 -8.758 3.017 -5.223 1.00 97.65 C \\\\nATOM 2414 CB VAL A 303 -8.101 0.632 -5.703 1.00 97.65 C \\\\nATOM 2415 O VAL A 303 -9.085 3.566 -6.279 1.00 97.65 O \\\\nATOM 2416 CG1 VAL A 303 -6.685 0.759 -5.122 1.00 97.65 C \\\\nATOM 2417 CG2 VAL A 303 -8.473 -0.853 -5.616 1.00 97.65 C \\\\nATOM 2418 N PHE A 304 -8.050 3.639 -4.287 1.00 98.07 N \\\\nATOM 2419 CA PHE A 304 -7.582 5.017 -4.387 1.00 98.07 C \\\\nATOM 2420 C PHE A 304 -6.065 5.109 -4.219 1.00 98.07 C \\\\nATOM 2421 CB PHE A 304 -8.259 5.861 -3.314 1.00 98.07 C \\\\nATOM 2422 O PHE A 304 -5.465 4.343 -3.462 1.00 98.07 O \\\\nATOM 2423 CG PHE A 304 -9.768 5.994 -3.396 1.00 98.07 C \\\\nATOM 2424 CD1 PHE A 304 -10.346 7.178 -3.895 1.00 98.07 C \\\\nATOM 2425 CD2 PHE A 304 -10.598 4.970 -2.898 1.00 98.07 C \\\\nATOM 2426 CE1 PHE A 304 -11.745 7.331 -3.908 1.00 98.07 C \\\\nATOM 2427 CE2 PHE A 304 -11.993 5.130 -2.902 1.00 98.07 C \\\\nATOM 2428 CZ PHE A 304 -12.568 6.303 -3.416 1.00 98.07 C \\\\nATOM 2429 N ALA A 305 -5.465 6.102 -4.876 1.00 98.57 N \\\\nATOM 2430 CA ALA A 305 -4.087 6.528 -4.654 1.00 98.57 C \\\\nATOM 2431 C ALA A 305 -4.061 7.952 -4.097 1.00 98.57 C \\\\nATOM 2432 CB ALA A 305 -3.307 6.433 -5.966 1.00 98.57 C \\\\nATOM 2433 O ALA A 305 -4.728 8.836 -4.629 1.00 98.57 O \\\\nATOM 2434 N GLU A 306 -3.273 8.188 -3.053 1.00 98.38 N \\\\nATOM 2435 CA GLU A 306 -3.106 9.485 -2.395 1.00 98.38 C \\\\nATOM 2436 C GLU A 306 -1.620 9.847 -2.324 1.00 98.38 C \\\\nATOM 2437 CB GLU A 306 -3.768 9.411 -1.014 1.00 98.38 C \\\\nATOM 2438 O GLU A 306 -0.812 9.109 -1.754 1.00 98.38 O \\\\nATOM 2439 CG GLU A 306 -3.686 10.690 -0.165 1.00 98.38 C \\\\nATOM 2440 CD GLU A 306 -4.307 10.462 1.224 1.00 98.38 C \\\\nATOM 2441 OE1 GLU A 306 -3.891 11.102 2.218 1.00 98.38 O \\\\nATOM 2442 OE2 GLU A 306 -5.160 9.553 1.396 1.00 98.38 O \\\\nATOM 2443 N CYS A 307 -1.250 10.987 -2.907 1.00 98.55 N \\\\nATOM 2444 CA CYS A 307 0.134 11.440 -2.960 1.00 98.55 C \\\\nATOM 2445 C CYS A 307 0.551 12.019 -1.602 1.00 98.55 C \\\\nATOM 2446 CB CYS A 307 0.277 12.448 -4.103 1.00 98.55 C \\\\nATOM 2447 O CYS A 307 0.202 13.148 -1.256 1.00 98.55 O \\\\nATOM 2448 SG CYS A 307 2.033 12.800 -4.388 1.00 98.55 S \\\\nATOM 2449 N LEU A 308 1.309 11.243 -0.824 1.00 98.21 N \\\\nATOM 2450 CA LEU A 308 1.869 11.676 0.458 1.00 98.21 C \\\\nATOM 2451 C LEU A 308 3.240 12.351 0.316 1.00 98.21 C \\\\nATOM 2452 CB LEU A 308 1.971 10.471 1.404 1.00 98.21 C \\\\nATOM 2453 O LEU A 308 3.667 13.040 1.247 1.00 98.21 O \\\\nATOM 2454 CG LEU A 308 0.651 9.781 1.786 1.00 98.21 C \\\\nATOM 2455 CD1 LEU A 308 0.945 8.821 2.942 1.00 98.21 C \\\\nATOM 2456 CD2 LEU A 308 -0.428 10.758 2.256 1.00 98.21 C \\\\nATOM 2457 N SER A 309 3.918 12.113 -0.808 1.00 98.38 N \\\\nATOM 2458 CA SER A 309 5.160 12.764 -1.220 1.00 98.38 C \\\\nATOM 2459 C SER A 309 4.962 14.255 -1.504 1.00 98.38 C \\\\nATOM 2460 CB SER A 309 5.692 12.085 -2.486 1.00 98.38 C \\\\nATOM 2461 O SER A 309 3.910 14.669 -1.993 1.00 98.38 O \\\\nATOM 2462 OG SER A 309 6.949 12.629 -2.837 1.00 98.38 O \\\\nATOM 2463 N ASP A 310 6.018 15.035 -1.266 1.00 98.37 N \\\\nATOM 2464 CA ASP A 310 6.132 16.441 -1.669 1.00 98.37 C \\\\nATOM 2465 C ASP A 310 6.377 16.594 -3.189 1.00 98.37 C \\\\nATOM 2466 CB ASP A 310 7.257 17.105 -0.855 1.00 98.37 C \\\\nATOM 2467 O ASP A 310 6.329 17.696 -3.731 1.00 98.37 O \\\\nATOM 2468 CG ASP A 310 7.108 16.885 0.657 1.00 98.37 C \\\\nATOM 2469 OD1 ASP A 310 6.020 17.183 1.199 1.00 98.37 O \\\\nATOM 2470 OD2 ASP A 310 8.070 16.356 1.258 1.00 98.37 O \\\\nATOM 2471 N SER A 311 6.618 15.485 -3.899 1.00 98.40 N \\\\nATOM 2472 CA SER A 311 6.662 15.398 -5.363 1.00 98.40 C \\\\nATOM 2473 C SER A 311 5.446 14.649 -5.905 1.00 98.40 C \\\\nATOM 2474 CB SER A 311 7.935 14.680 -5.804 1.00 98.40 C \\\\nATOM 2475 O SER A 311 5.000 13.672 -5.314 1.00 98.40 O \\\\nATOM 2476 OG SER A 311 9.054 15.498 -5.541 1.00 98.40 O \\\\nATOM 2477 N ALA A 312 4.929 15.070 -7.062 1.00 98.66 N \\\\nATOM 2478 CA ALA A 312 3.782 14.415 -7.693 1.00 98.66 C \\\\nATOM 2479 C ALA A 312 4.071 12.953 -8.088 1.00 98.66 C \\\\nATOM 2480 CB ALA A 312 3.342 15.240 -8.910 1.00 98.66 C \\\\nATOM 2481 O ALA A 312 5.201 12.598 -8.445 1.00 98.66 O \\\\nATOM 2482 N ILE A 313 3.015 12.141 -8.102 1.00 98.82 N \\\\nATOM 2483 CA ILE A 313 2.999 10.804 -8.707 1.00 98.82 C \\\\nATOM 2484 C ILE A 313 2.170 10.823 -9.996 1.00 98.82 C \\\\nATOM 2485 CB ILE A 313 2.538 9.719 -7.707 1.00 98.82 C \\\\nATOM 2486 O ILE A 313 1.347 11.714 -10.212 1.00 98.82 O \\\\nATOM 2487 CG1 ILE A 313 1.073 9.935 -7.277 1.00 98.82 C \\\\nATOM 2488 CG2 ILE A 313 3.504 9.665 -6.509 1.00 98.82 C \\\\nATOM 2489 CD1 ILE A 313 0.539 8.921 -6.265 1.00 98.82 C \\\\nATOM 2490 N PHE A 314 2.401 9.848 -10.865 1.00 98.73 N \\\\nATOM 2491 CA PHE A 314 1.799 9.763 -12.195 1.00 98.73 C \\\\nATOM 2492 C PHE A 314 1.232 8.361 -12.370 1.00 98.73 C \\\\nATOM 2493 CB PHE A 314 2.873 10.087 -13.242 1.00 98.73 C \\\\nATOM 2494 O PHE A 314 1.959 7.403 -12.131 1.00 98.73 O \\\\nATOM 2495 CG PHE A 314 3.483 11.464 -13.086 1.00 98.73 C \\\\nATOM 2496 CD1 PHE A 314 2.991 12.550 -13.832 1.00 98.73 C \\\\nATOM 2497 CD2 PHE A 314 4.534 11.664 -12.170 1.00 98.73 C \\\\nATOM 2498 CE1 PHE A 314 3.556 13.826 -13.660 1.00 98.73 C \\\\nATOM 2499 CE2 PHE A 314 5.066 12.949 -11.972 1.00 98.73 C \\\\nATOM 2500 CZ PHE A 314 4.588 14.029 -12.729 1.00 98.73 C \\\\nATOM 2501 N VAL A 315 -0.044 8.232 -12.728 1.00 98.59 N \\\\nATOM 2502 CA VAL A 315 -0.794 6.970 -12.686 1.00 98.59 C \\\\nATOM 2503 C VAL A 315 -1.401 6.660 -14.047 1.00 98.59 C \\\\nATOM 2504 CB VAL A 315 -1.905 7.017 -11.616 1.00 98.59 C \\\\nATOM 2505 O VAL A 315 -2.157 7.463 -14.581 1.00 98.59 O \\\\nATOM 2506 CG1 VAL A 315 -2.648 5.676 -11.526 1.00 98.59 C \\\\nATOM 2507 CG2 VAL A 315 -1.334 7.361 -10.232 1.00 98.59 C \\\\nATOM 2508 N GLN A 316 -1.131 5.467 -14.567 1.00 98.50 N \\\\nATOM 2509 CA GLN A 316 -1.849 4.879 -15.694 1.00 98.50 C \\\\nATOM 2510 C GLN A 316 -2.736 3.760 -15.142 1.00 98.50 C \\\\nATOM 2511 CB GLN A 316 -0.823 4.384 -16.721 1.00 98.50 C \\\\nATOM 2512 O GLN A 316 -2.234 2.719 -14.716 1.00 98.50 O \\\\nATOM 2513 CG GLN A 316 -1.429 3.791 -17.999 1.00 98.50 C \\\\nATOM 2514 CD GLN A 316 -0.336 3.221 -18.902 1.00 98.50 C \\\\nATOM 2515 NE2 GLN A 316 -0.040 3.836 -20.027 1.00 98.50 N \\\\nATOM 2516 OE1 GLN A 316 0.309 2.230 -18.589 1.00 98.50 O \\\\nATOM 2517 N SER A 317 -4.049 3.996 -15.117 1.00 98.39 N \\\\nATOM 2518 CA SER A 317 -5.060 2.984 -14.795 1.00 98.39 C \\\\nATOM 2519 C SER A 317 -6.089 2.946 -15.923 1.00 98.39 C \\\\nATOM 2520 CB SER A 317 -5.762 3.277 -13.467 1.00 98.39 C \\\\nATOM 2521 O SER A 317 -6.858 3.903 -16.054 1.00 98.39 O \\\\nATOM 2522 OG SER A 317 -6.874 2.408 -13.353 1.00 98.39 O \\\\nATOM 2523 N PRO A 318 -6.152 1.862 -16.715 1.00 97.77 N \\\\nATOM 2524 CA PRO A 318 -7.133 1.740 -17.789 1.00 97.77 C \\\\nATOM 2525 C PRO A 318 -8.589 1.853 -17.303 1.00 97.77 C \\\\nATOM 2526 CB PRO A 318 -6.821 0.396 -18.446 1.00 97.77 C \\\\nATOM 2527 O PRO A 318 -9.390 2.516 -17.953 1.00 97.77 O \\\\nATOM 2528 CG PRO A 318 -5.322 0.232 -18.214 1.00 97.77 C \\\\nATOM 2529 CD PRO A 318 -5.171 0.786 -16.801 1.00 97.77 C \\\\nATOM 2530 N ASN A 319 -8.918 1.326 -16.113 1.00 97.99 N \\\\nATOM 2531 CA ASN A 319 -10.244 1.493 -15.496 1.00 97.99 C \\\\nATOM 2532 C ASN A 319 -10.566 2.966 -15.183 1.00 97.99 C \\\\nATOM 2533 CB ASN A 319 -10.309 0.611 -14.236 1.00 97.99 C \\\\nATOM 2534 O ASN A 319 -11.661 3.438 -15.478 1.00 97.99 O \\\\nATOM 2535 CG ASN A 319 -11.614 0.775 -13.470 1.00 97.99 C \\\\nATOM 2536 ND2 ASN A 319 -12.663 0.081 -13.837 1.00 97.99 N \\\\nATOM 2537 OD1 ASN A 319 -11.698 1.547 -12.527 1.00 97.99 O \\\\nATOM 2538 N CYS A 320 -9.600 3.715 -14.641 1.00 97.61 N \\\\nATOM 2539 CA CYS A 320 -9.765 5.149 -14.404 1.00 97.61 C \\\\nATOM 2540 C CYS A 320 -9.915 5.926 -15.721 1.00 97.61 C \\\\nATOM 2541 CB CYS A 320 -8.560 5.644 -13.598 1.00 97.61 C \\\\nATOM 2542 O CYS A 320 -10.769 6.803 -15.818 1.00 97.61 O \\\\nATOM 2543 SG CYS A 320 -8.805 7.360 -13.069 1.00 97.61 S \\\\nATOM 2544 N ASN A 321 -9.107 5.597 -16.730 1.00 97.67 N \\\\nATOM 2545 CA ASN A 321 -9.126 6.263 -18.030 1.00 97.67 C \\\\nATOM 2546 C ASN A 321 -10.470 6.049 -18.742 1.00 97.67 C \\\\nATOM 2547 CB ASN A 321 -7.913 5.779 -18.849 1.00 97.67 C \\\\nATOM 2548 O ASN A 321 -11.088 7.022 -19.169 1.00 97.67 O \\\\nATOM 2549 CG ASN A 321 -6.587 6.264 -18.280 1.00 97.67 C \\\\nATOM 2550 ND2 ASN A 321 -5.481 5.659 -18.640 1.00 97.67 N \\\\nATOM 2551 OD1 ASN A 321 -6.511 7.213 -17.517 1.00 97.67 O \\\\nATOM 2552 N GLN A 322 -10.981 4.814 -18.757 1.00 96.68 N \\\\nATOM 2553 CA GLN A 322 -12.291 4.489 -19.322 1.00 96.68 C \\\\nATOM 2554 C GLN A 322 -13.438 5.228 -18.615 1.00 96.68 C \\\\nATOM 2555 CB GLN A 322 -12.479 2.967 -19.285 1.00 96.68 C \\\\nATOM 2556 O GLN A 322 -14.307 5.769 -19.296 1.00 96.68 O \\\\nATOM 2557 CG GLN A 322 -13.796 2.518 -19.940 1.00 96.68 C \\\\nATOM 2558 CD GLN A 322 -13.909 1.001 -20.053 1.00 96.68 C \\\\nATOM 2559 NE2 GLN A 322 -15.063 0.474 -20.393 1.00 96.68 N \\\\nATOM 2560 OE1 GLN A 322 -12.970 0.258 -19.833 1.00 96.68 O \\\\nATOM 2561 N ARG A 323 -13.426 5.330 -17.274 1.00 96.89 N \\\\nATOM 2562 CA ARG A 323 -14.443 6.083 -16.507 1.00 96.89 C \\\\nATOM 2563 C ARG A 323 -14.564 7.543 -16.958 1.00 96.89 C \\\\nATOM 2564 CB ARG A 323 -14.107 6.024 -15.006 1.00 96.89 C \\\\nATOM 2565 O ARG A 323 -15.663 8.090 -16.961 1.00 96.89 O \\\\nATOM 2566 CG ARG A 323 -15.199 6.657 -14.117 1.00 96.89 C \\\\nATOM 2567 CD ARG A 323 -14.716 6.904 -12.685 1.00 96.89 C \\\\nATOM 2568 NE ARG A 323 -14.325 5.643 -12.043 1.00 96.89 N \\\\nATOM 2569 NH1 ARG A 323 -12.182 6.137 -11.428 1.00 96.89 N \\\\nATOM 2570 NH2 ARG A 323 -12.918 4.017 -11.386 1.00 96.89 N \\\\nATOM 2571 CZ ARG A 323 -13.140 5.272 -11.615 1.00 96.89 C \\\\nATOM 2572 N TYR A 324 -13.446 8.175 -17.312 1.00 96.60 N \\\\nATOM 2573 CA TYR A 324 -13.397 9.579 -17.733 1.00 96.60 C \\\\nATOM 2574 C TYR A 324 -13.390 9.773 -19.261 1.00 96.60 C \\\\nATOM 2575 CB TYR A 324 -12.221 10.278 -17.032 1.00 96.60 C \\\\nATOM 2576 O TYR A 324 -13.228 10.900 -19.721 1.00 96.60 O \\\\nATOM 2577 CG TYR A 324 -12.352 10.360 -15.519 1.00 96.60 C \\\\nATOM 2578 CD1 TYR A 324 -13.401 11.106 -14.946 1.00 96.60 C \\\\nATOM 2579 CD2 TYR A 324 -11.424 9.710 -14.684 1.00 96.60 C \\\\nATOM 2580 CE1 TYR A 324 -13.535 11.186 -13.547 1.00 96.60 C \\\\nATOM 2581 CE2 TYR A 324 -11.555 9.779 -13.283 1.00 96.60 C \\\\nATOM 2582 OH TYR A 324 -12.750 10.575 -11.362 1.00 96.60 O \\\\nATOM 2583 CZ TYR A 324 -12.613 10.515 -12.714 1.00 96.60 C \\\\nATOM 2584 N GLY A 325 -13.566 8.706 -20.052 1.00 96.83 N \\\\nATOM 2585 CA GLY A 325 -13.546 8.778 -21.518 1.00 96.83 C \\\\nATOM 2586 C GLY A 325 -12.171 9.110 -22.114 1.00 96.83 C \\\\nATOM 2587 O GLY A 325 -12.085 9.595 -23.239 1.00 96.83 O \\\\nATOM 2588 N TRP A 326 -11.088 8.885 -21.368 1.00 96.86 N \\\\nATOM 2589 CA TRP A 326 -9.719 9.104 -21.832 1.00 96.86 C \\\\nATOM 2590 C TRP A 326 -9.160 7.863 -22.529 1.00 96.86 C \\\\nATOM 2591 CB TRP A 326 -8.824 9.520 -20.657 1.00 96.86 C \\\\nATOM 2592 O TRP A 326 -9.530 6.733 -22.211 1.00 96.86 O \\\\nATOM 2593 CG TRP A 326 -9.208 10.774 -19.932 1.00 96.86 C \\\\nATOM 2594 CD1 TRP A 326 -9.869 11.827 -20.467 1.00 96.86 C \\\\nATOM 2595 CD2 TRP A 326 -9.012 11.108 -18.521 1.00 96.86 C \\\\nATOM 2596 CE2 TRP A 326 -9.585 12.393 -18.279 1.00 96.86 C \\\\nATOM 2597 CE3 TRP A 326 -8.445 10.441 -17.410 1.00 96.86 C \\\\nATOM 2598 NE1 TRP A 326 -10.085 12.785 -19.500 1.00 96.86 N \\\\nATOM 2599 CH2 TRP A 326 -9.046 12.288 -15.922 1.00 96.86 C \\\\nATOM 2600 CZ2 TRP A 326 -9.597 12.988 -17.008 1.00 96.86 C \\\\nATOM 2601 CZ3 TRP A 326 -8.480 11.017 -16.125 1.00 96.86 C \\\\nATOM 2602 N HIS A 327 -8.192 8.071 -23.429 1.00 96.47 N \\\\nATOM 2603 CA HIS A 327 -7.456 6.975 -24.059 1.00 96.47 C \\\\nATOM 2604 C HIS A 327 -6.885 6.008 -22.993 1.00 96.47 C \\\\nATOM 2605 CB HIS A 327 -6.341 7.555 -24.942 1.00 96.47 C \\\\nATOM 2606 O HIS A 327 -6.330 6.481 -21.996 1.00 96.47 O \\\\nATOM 2607 CG HIS A 327 -5.666 6.498 -25.775 1.00 96.47 C \\\\nATOM 2608 CD2 HIS A 327 -6.181 5.901 -26.894 1.00 96.47 C \\\\nATOM 2609 ND1 HIS A 327 -4.451 5.902 -25.523 1.00 96.47 N \\\\nATOM 2610 CE1 HIS A 327 -4.247 4.955 -26.458 1.00 96.47 C \\\\nATOM 2611 NE2 HIS A 327 -5.285 4.912 -27.299 1.00 96.47 N \\\\nATOM 2612 N PRO A 328 -6.948 4.670 -23.168 1.00 94.55 N \\\\nATOM 2613 CA PRO A 328 -6.511 3.714 -22.142 1.00 94.55 C \\\\nATOM 2614 C PRO A 328 -5.063 3.912 -21.667 1.00 94.55 C \\\\nATOM 2615 CB PRO A 328 -6.707 2.331 -22.770 1.00 94.55 C \\\\nATOM 2616 O PRO A 328 -4.744 3.622 -20.514 1.00 94.55 O \\\\nATOM 2617 CG PRO A 328 -7.873 2.550 -23.731 1.00 94.55 C \\\\nATOM 2618 CD PRO A 328 -7.614 3.961 -24.254 1.00 94.55 C \\\\nATOM 2619 N ALA A 329 -4.203 4.470 -22.525 1.00 95.38 N \\\\nATOM 2620 CA ALA A 329 -2.805 4.780 -22.223 1.00 95.38 C \\\\nATOM 2621 C ALA A 329 -2.573 6.023 -21.339 1.00 95.38 C \\\\nATOM 2622 CB ALA A 329 -2.057 4.963 -23.546 1.00 95.38 C \\\\nATOM 2623 O ALA A 329 -1.431 6.232 -20.922 1.00 95.38 O \\\\nATOM 2624 N THR A 330 -3.592 6.859 -21.101 1.00 97.03 N \\\\nATOM 2625 CA THR A 330 -3.469 8.168 -20.437 1.00 97.03 C \\\\nATOM 2626 C THR A 330 -2.818 8.070 -19.056 1.00 97.03 C \\\\nATOM 2627 CB THR A 330 -4.839 8.868 -20.371 1.00 97.03 C \\\\nATOM 2628 O THR A 330 -3.058 7.131 -18.293 1.00 97.03 O \\\\nATOM 2629 CG2 THR A 330 -4.888 10.148 -19.534 1.00 97.03 C \\\\nATOM 2630 OG1 THR A 330 -5.162 9.258 -21.682 1.00 97.03 O \\\\nATOM 2631 N VAL A 331 -1.977 9.059 -18.743 1.00 98.32 N \\\\nATOM 2632 CA VAL A 331 -1.197 9.127 -17.503 1.00 98.32 C \\\\nATOM 2633 C VAL A 331 -1.662 10.319 -16.667 1.00 98.32 C \\\\nATOM 2634 CB VAL A 331 0.314 9.177 -17.801 1.00 98.32 C \\\\nATOM 2635 O VAL A 331 -1.331 11.473 -16.939 1.00 98.32 O \\\\nATOM 2636 CG1 VAL A 331 1.119 9.167 -16.496 1.00 98.32 C \\\\nATOM 2637 CG2 VAL A 331 0.754 7.971 -18.641 1.00 98.32 C \\\\nATOM 2638 N CYS A 332 -2.424 10.038 -15.616 1.00 97.93 N \\\\nATOM 2639 CA CYS A 332 -2.985 11.032 -14.711 1.00 97.93 C \\\\nATOM 2640 C CYS A 332 -1.943 11.484 -13.678 1.00 97.93 C \\\\nATOM 2641 CB CYS A 332 -4.212 10.433 -14.013 1.00 97.93 C \\\\nATOM 2642 O CYS A 332 -1.425 10.677 -12.904 1.00 97.93 O \\\\nATOM 2643 SG CYS A 332 -5.401 9.801 -15.228 1.00 97.93 S \\\\nATOM 2644 N LYS A 333 -1.662 12.786 -13.603 1.00 98.40 N \\\\nATOM 2645 CA LYS A 333 -0.823 13.367 -12.544 1.00 98.40 C \\\\nATOM 2646 C LYS A 333 -1.639 13.558 -11.262 1.00 98.40 C \\\\nATOM 2647 CB LYS A 333 -0.231 14.684 -13.062 1.00 98.40 C \\\\nATOM 2648 O LYS A 333 -2.661 14.236 -11.287 1.00 98.40 O \\\\nATOM 2649 CG LYS A 333 0.684 15.383 -12.046 1.00 98.40 C \\\\nATOM 2650 CD LYS A 333 1.203 16.686 -12.664 1.00 98.40 C \\\\nATOM 2651 CE LYS A 333 2.105 17.450 -11.694 1.00 98.40 C \\\\nATOM 2652 NZ LYS A 333 2.527 18.742 -12.291 1.00 98.40 N \\\\nATOM 2653 N ILE A 334 -1.145 13.050 -10.134 1.00 98.51 N \\\\nATOM 2654 CA ILE A 334 -1.685 13.314 -8.792 1.00 98.51 C \\\\nATOM 2655 C ILE A 334 -0.687 14.224 -8.050 1.00 98.51 C \\\\nATOM 2656 CB ILE A 334 -1.975 12.007 -8.019 1.00 98.51 C \\\\nATOM 2657 O ILE A 334 0.409 13.772 -7.703 1.00 98.51 O \\\\nATOM 2658 CG1 ILE A 334 -2.838 11.022 -8.842 1.00 98.51 C \\\\nATOM 2659 CG2 ILE A 334 -2.655 12.336 -6.674 1.00 98.51 C \\\\nATOM 2660 CD1 ILE A 334 -3.066 9.673 -8.151 1.00 98.51 C \\\\nATOM 2661 N PRO A 335 -1.013 15.514 -7.831 1.00 98.57 N \\\\nATOM 2662 CA PRO A 335 -0.159 16.433 -7.078 1.00 98.57 C \\\\nATOM 2663 C PRO A 335 -0.027 16.061 -5.586 1.00 98.57 C \\\\nATOM 2664 CB PRO A 335 -0.788 17.823 -7.244 1.00 98.57 C \\\\nATOM 2665 O PRO A 335 -0.885 15.351 -5.057 1.00 98.57 O \\\\nATOM 2666 CG PRO A 335 -1.649 17.696 -8.499 1.00 98.57 C \\\\nATOM 2667 CD PRO A 335 -2.117 16.247 -8.435 1.00 98.57 C \\\\nATOM 2668 N PRO A 336 0.997 16.579 -4.880 1.00 98.51 N \\\\nATOM 2669 CA PRO A 336 1.147 16.432 -3.429 1.00 98.51 C \\\\nATOM 2670 C PRO A 336 -0.131 16.770 -2.651 1.00 98.51 C \\\\nATOM 2671 CB PRO A 336 2.291 17.377 -3.044 1.00 98.51 C \\\\nATOM 2672 O PRO A 336 -0.737 17.819 -2.856 1.00 98.51 O \\\\nATOM 2673 CG PRO A 336 3.155 17.374 -4.300 1.00 98.51 C \\\\nATOM 2674 CD PRO A 336 2.115 17.342 -5.414 1.00 98.51 C \\\\nATOM 2675 N GLY A 337 -0.549 15.876 -1.752 1.00 95.96 N \\\\nATOM 2676 CA GLY A 337 -1.767 16.020 -0.948 1.00 95.96 C \\\\nATOM 2677 C GLY A 337 -3.084 15.715 -1.678 1.00 95.96 C \\\\nATOM 2678 O GLY A 337 -4.129 15.661 -1.028 1.00 95.96 O \\\\nATOM 2679 N CYS A 338 -3.066 15.485 -2.994 1.00 97.97 N \\\\nATOM 2680 CA CYS A 338 -4.239 15.055 -3.755 1.00 97.97 C \\\\nATOM 2681 C CYS A 338 -4.426 13.529 -3.706 1.00 97.97 C \\\\nATOM 2682 CB CYS A 338 -4.149 15.568 -5.200 1.00 97.97 C \\\\nATOM 2683 O CYS A 338 -3.501 12.769 -3.408 1.00 97.97 O \\\\nATOM 2684 SG CYS A 338 -4.101 17.385 -5.234 1.00 97.97 S \\\\nATOM 2685 N ASN A 339 -5.636 13.079 -4.040 1.00 97.19 N \\\\nATOM 2686 CA ASN A 339 -5.968 11.670 -4.234 1.00 97.19 C \\\\nATOM 2687 C ASN A 339 -6.816 11.470 -5.499 1.00 97.19 C \\\\nATOM 2688 CB ASN A 339 -6.641 11.094 -2.973 1.00 97.19 C \\\\nATOM 2689 O ASN A 339 -7.424 12.420 -5.991 1.00 97.19 O \\\\nATOM 2690 CG ASN A 339 -8.006 11.697 -2.697 1.00 97.19 C \\\\nATOM 2691 ND2 ASN A 339 -8.068 12.787 -1.966 1.00 97.19 N \\\\nATOM 2692 OD1 ASN A 339 -9.032 11.213 -3.137 1.00 97.19 O \\\\nATOM 2693 N LEU A 340 -6.834 10.241 -6.013 1.00 97.74 N \\\\nATOM 2694 CA LEU A 340 -7.588 9.821 -7.194 1.00 97.74 C \\\\nATOM 2695 C LEU A 340 -8.170 8.421 -6.967 1.00 97.74 C \\\\nATOM 2696 CB LEU A 340 -6.636 9.839 -8.406 1.00 97.74 C \\\\nATOM 2697 O LEU A 340 -7.485 7.548 -6.431 1.00 97.74 O \\\\nATOM 2698 CG LEU A 340 -7.252 9.450 -9.765 1.00 97.74 C \\\\nATOM 2699 CD1 LEU A 340 -8.359 10.414 -10.195 1.00 97.74 C \\\\nATOM 2700 CD2 LEU A 340 -6.159 9.459 -10.835 1.00 97.74 C \\\\nATOM 2701 N LYS A 341 -9.407 8.188 -7.420 1.00 97.97 N \\\\nATOM 2702 CA LYS A 341 -10.010 6.849 -7.498 1.00 97.97 C \\\\nATOM 2703 C LYS A 341 -9.441 6.115 -8.710 1.00 97.97 C \\\\nATOM 2704 CB LYS A 341 -11.538 6.971 -7.566 1.00 97.97 C \\\\nATOM 2705 O LYS A 341 -9.873 6.340 -9.838 1.00 97.97 O \\\\nATOM 2706 CG LYS A 341 -12.210 5.588 -7.497 1.00 97.97 C \\\\nATOM 2707 CD LYS A 341 -13.726 5.666 -7.704 1.00 97.97 C \\\\nATOM 2708 CE LYS A 341 -14.397 6.548 -6.645 1.00 97.97 C \\\\nATOM 2709 NZ LYS A 341 -15.870 6.475 -6.744 1.00 97.97 N \\\\nATOM 2710 N ILE A 342 -8.457 5.254 -8.483 1.00 98.34 N \\\\nATOM 2711 CA ILE A 342 -7.732 4.562 -9.552 1.00 98.34 C \\\\nATOM 2712 C ILE A 342 -8.460 3.309 -10.050 1.00 98.34 C \\\\nATOM 2713 CB ILE A 342 -6.280 4.249 -9.132 1.00 98.34 C \\\\nATOM 2714 O ILE A 342 -8.189 2.889 -11.168 1.00 98.34 O \\\\nATOM 2715 CG1 ILE A 342 -6.231 3.224 -7.976 1.00 98.34 C \\\\nATOM 2716 CG2 ILE A 342 -5.535 5.553 -8.793 1.00 98.34 C \\\\nATOM 2717 CD1 ILE A 342 -4.827 2.765 -7.596 1.00 98.34 C \\\\nATOM 2718 N PHE A 343 -9.368 2.720 -9.264 1.00 98.38 N \\\\nATOM 2719 CA PHE A 343 -10.139 1.539 -9.668 1.00 98.38 C \\\\nATOM 2720 C PHE A 343 -11.522 1.488 -9.004 1.00 98.38 C \\\\nATOM 2721 CB PHE A 343 -9.354 0.262 -9.343 1.00 98.38 C \\\\nATOM 2722 O PHE A 343 -11.668 1.935 -7.865 1.00 98.38 O \\\\nATOM 2723 CG PHE A 343 -9.807 -0.946 -10.137 1.00 98.38 C \\\\nATOM 2724 CD1 PHE A 343 -10.721 -1.865 -9.586 1.00 98.38 C \\\\nATOM 2725 CD2 PHE A 343 -9.294 -1.165 -11.430 1.00 98.38 C \\\\nATOM 2726 CE1 PHE A 343 -11.108 -2.997 -10.323 1.00 98.38 C \\\\nATOM 2727 CE2 PHE A 343 -9.684 -2.301 -12.160 1.00 98.38 C \\\\nATOM 2728 CZ PHE A 343 -10.580 -3.224 -11.602 1.00 98.38 C \\\\nATOM 2729 N ASN A 344 -12.511 0.898 -9.675 1.00 96.95 N \\\\nATOM 2730 CA ASN A 344 -13.810 0.538 -9.101 1.00 96.95 C \\\\nATOM 2731 C ASN A 344 -14.249 -0.852 -9.617 1.00 96.95 C \\\\nATOM 2732 CB ASN A 344 -14.811 1.671 -9.406 1.00 96.95 C \\\\nATOM 2733 O ASN A 344 -14.299 -1.098 -10.824 1.00 96.95 O \\\\nATOM 2734 CG ASN A 344 -16.252 1.329 -9.067 1.00 96.95 C \\\\nATOM 2735 ND2 ASN A 344 -16.917 2.009 -8.169 1.00 96.95 N \\\\nATOM 2736 OD1 ASN A 344 -16.815 0.393 -9.597 1.00 96.95 O \\\\nATOM 2737 N ASN A 345 -14.585 -1.756 -8.691 1.00 95.65 N \\\\nATOM 2738 CA ASN A 345 -14.955 -3.140 -8.994 1.00 95.65 C \\\\nATOM 2739 C ASN A 345 -16.313 -3.279 -9.705 1.00 95.65 C \\\\nATOM 2740 CB ASN A 345 -14.978 -3.970 -7.695 1.00 95.65 C \\\\nATOM 2741 O ASN A 345 -16.496 -4.245 -10.438 1.00 95.65 O \\\\nATOM 2742 CG ASN A 345 -13.622 -4.311 -7.098 1.00 95.65 C \\\\nATOM 2743 ND2 ASN A 345 -13.616 -5.022 -5.996 1.00 95.65 N \\\\nATOM 2744 OD1 ASN A 345 -12.567 -3.976 -7.606 1.00 95.65 O \\\\nATOM 2745 N GLN A 346 -17.266 -2.360 -9.509 1.00 95.14 N \\\\nATOM 2746 CA GLN A 346 -18.570 -2.389 -10.192 1.00 95.14 C \\\\nATOM 2747 C GLN A 346 -18.434 -2.020 -11.675 1.00 95.14 C \\\\nATOM 2748 CB GLN A 346 -19.572 -1.432 -9.520 1.00 95.14 C \\\\nATOM 2749 O GLN A 346 -19.045 -2.656 -12.528 1.00 95.14 O \\\\nATOM 2750 CG GLN A 346 -19.850 -1.744 -8.045 1.00 95.14 C \\\\nATOM 2751 CD GLN A 346 -20.867 -0.771 -7.458 1.00 95.14 C \\\\nATOM 2752 NE2 GLN A 346 -21.978 -1.246 -6.939 1.00 95.14 N \\\\nATOM 2753 OE1 GLN A 346 -20.692 0.434 -7.453 1.00 95.14 O \\\\nATOM 2754 N GLU A 347 -17.593 -1.034 -11.990 1.00 95.97 N \\\\nATOM 2755 CA GLU A 347 -17.256 -0.657 -13.367 1.00 95.97 C \\\\nATOM 2756 C GLU A 347 -16.535 -1.805 -14.087 1.00 95.97 C \\\\nATOM 2757 CB GLU A 347 -16.368 0.596 -13.346 1.00 95.97 C \\\\nATOM 2758 O GLU A 347 -16.882 -2.144 -15.217 1.00 95.97 O \\\\nATOM 2759 CG GLU A 347 -17.108 1.858 -12.867 1.00 95.97 C \\\\nATOM 2760 CD GLU A 347 -16.146 3.008 -12.540 1.00 95.97 C \\\\nATOM 2761 OE1 GLU A 347 -16.567 4.018 -11.935 1.00 95.97 O \\\\nATOM 2762 OE2 GLU A 347 -14.927 2.898 -12.799 1.00 95.97 O \\\\nATOM 2763 N PHE A 348 -15.586 -2.464 -13.409 1.00 97.03 N \\\\nATOM 2764 CA PHE A 348 -14.939 -3.667 -13.936 1.00 97.03 C \\\\nATOM 2765 C PHE A 348 -15.919 -4.841 -14.102 1.00 97.03 C \\\\nATOM 2766 CB PHE A 348 -13.752 -4.044 -13.043 1.00 97.03 C \\\\nATOM 2767 O PHE A 348 -15.876 -5.515 -15.126 1.00 97.03 O \\\\nATOM 2768 CG PHE A 348 -13.012 -5.279 -13.524 1.00 97.03 C \\\\nATOM 2769 CD1 PHE A 348 -13.244 -6.527 -12.912 1.00 97.03 C \\\\nATOM 2770 CD2 PHE A 348 -12.127 -5.191 -14.616 1.00 97.03 C \\\\nATOM 2771 CE1 PHE A 348 -12.591 -7.679 -13.387 1.00 97.03 C \\\\nATOM 2772 CE2 PHE A 348 -11.474 -6.344 -15.089 1.00 97.03 C \\\\nATOM 2773 CZ PHE A 348 -11.706 -7.586 -14.474 1.00 97.03 C \\\\nATOM 2774 N ALA A 349 -16.836 -5.061 -13.151 1.00 95.38 N \\\\nATOM 2775 CA ALA A 349 -17.877 -6.089 -13.243 1.00 95.38 C \\\\nATOM 2776 C ALA A 349 -18.769 -5.904 -14.478 1.00 95.38 C \\\\nATOM 2777 CB ALA A 349 -18.758 -6.034 -11.985 1.00 95.38 C \\\\nATOM 2778 O ALA A 349 -19.033 -6.861 -15.205 1.00 95.38 O \\\\nATOM 2779 N ALA A 350 -19.224 -4.669 -14.713 1.00 95.44 N \\\\nATOM 2780 CA ALA A 350 -20.069 -4.329 -15.850 1.00 95.44 C \\\\nATOM 2781 C ALA A 350 -19.336 -4.555 -17.180 1.00 95.44 C \\\\nATOM 2782 CB ALA A 350 -20.535 -2.877 -15.689 1.00 95.44 C \\\\nATOM 2783 O ALA A 350 -19.901 -5.157 -18.091 1.00 95.44 O \\\\nATOM 2784 N LEU A 351 -18.068 -4.140 -17.268 1.00 95.45 N \\\\nATOM 2785 CA LEU A 351 -17.235 -4.369 -18.446 1.00 95.45 C \\\\nATOM 2786 C LEU A 351 -16.982 -5.863 -18.691 1.00 95.45 C \\\\nATOM 2787 CB LEU A 351 -15.927 -3.589 -18.264 1.00 95.45 C \\\\nATOM 2788 O LEU A 351 -17.164 -6.335 -19.808 1.00 95.45 O \\\\nATOM 2789 CG LEU A 351 -14.970 -3.702 -19.462 1.00 95.45 C \\\\nATOM 2790 CD1 LEU A 351 -15.584 -3.164 -20.755 1.00 95.45 C \\\\nATOM 2791 CD2 LEU A 351 -13.718 -2.901 -19.127 1.00 95.45 C \\\\nATOM 2792 N LEU A 352 -16.637 -6.626 -17.649 1.00 96.13 N \\\\nATOM 2793 CA LEU A 352 -16.427 -8.072 -17.739 1.00 96.13 C \\\\nATOM 2794 C LEU A 352 -17.687 -8.794 -18.240 1.00 96.13 C \\\\nATOM 2795 CB LEU A 352 -15.943 -8.577 -16.365 1.00 96.13 C \\\\nATOM 2796 O LEU A 352 -17.603 -9.603 -19.160 1.00 96.13 O \\\\nATOM 2797 CG LEU A 352 -15.683 -10.092 -16.272 1.00 96.13 C \\\\nATOM 2798 CD1 LEU A 352 -14.689 -10.587 -17.318 1.00 96.13 C \\\\nATOM 2799 CD2 LEU A 352 -15.118 -10.422 -14.887 1.00 96.13 C \\\\nATOM 2800 N ALA A 353 -18.862 -8.453 -17.703 1.00 94.39 N \\\\nATOM 2801 CA ALA A 353 -20.137 -9.006 -18.157 1.00 94.39 C \\\\nATOM 2802 C ALA A 353 -20.473 -8.643 -19.618 1.00 94.39 C \\\\nATOM 2803 CB ALA A 353 -21.234 -8.528 -17.198 1.00 94.39 C \\\\nATOM 2804 O ALA A 353 -21.095 -9.440 -20.318 1.00 94.39 O \\\\nATOM 2805 N GLN A 354 -20.057 -7.466 -20.099 1.00 94.04 N \\\\nATOM 2806 CA GLN A 354 -20.220 -7.067 -21.500 1.00 94.04 C \\\\nATOM 2807 C GLN A 354 -19.262 -7.839 -22.420 1.00 94.04 C \\\\nATOM 2808 CB GLN A 354 -20.038 -5.547 -21.636 1.00 94.04 C \\\\nATOM 2809 O GLN A 354 -19.718 -8.442 -23.394 1.00 94.04 O \\\\nATOM 2810 CG GLN A 354 -21.235 -4.775 -21.055 1.00 94.04 C \\\\nATOM 2811 CD GLN A 354 -20.982 -3.275 -20.915 1.00 94.04 C \\\\nATOM 2812 NE2 GLN A 354 -21.886 -2.546 -20.298 1.00 94.04 N \\\\nATOM 2813 OE1 GLN A 354 -19.994 -2.713 -21.353 1.00 94.04 O \\\\nATOM 2814 N SER A 355 -17.968 -7.887 -22.088 1.00 94.46 N \\\\nATOM 2815 CA SER A 355 -16.929 -8.520 -22.912 1.00 94.46 C \\\\nATOM 2816 C SER A 355 -17.077 -10.034 -23.059 1.00 94.46 C \\\\nATOM 2817 CB SER A 355 -15.537 -8.197 -22.368 1.00 94.46 C \\\\nATOM 2818 O SER A 355 -16.649 -10.571 -24.074 1.00 94.46 O \\\\nATOM 2819 OG SER A 355 -15.291 -6.809 -22.469 1.00 94.46 O \\\\nATOM 2820 N VAL A 356 -17.745 -10.732 -22.131 1.00 92.71 N \\\\nATOM 2821 CA VAL A 356 -18.093 -12.160 -22.307 1.00 92.71 C \\\\nATOM 2822 C VAL A 356 -18.860 -12.407 -23.613 1.00 92.71 C \\\\nATOM 2823 CB VAL A 356 -18.887 -12.669 -21.087 1.00 92.71 C \\\\nATOM 2824 O VAL A 356 -18.597 -13.386 -24.306 1.00 92.71 O \\\\nATOM 2825 CG1 VAL A 356 -19.590 -14.012 -21.311 1.00 92.71 C \\\\nATOM 2826 CG2 VAL A 356 -17.941 -12.871 -19.900 1.00 92.71 C \\\\nATOM 2827 N ASN A 357 -19.745 -11.487 -24.013 1.00 89.37 N \\\\nATOM 2828 CA ASN A 357 -20.513 -11.601 -25.261 1.00 89.37 C \\\\nATOM 2829 C ASN A 357 -19.690 -11.255 -26.519 1.00 89.37 C \\\\nATOM 2830 CB ASN A 357 -21.776 -10.732 -25.163 1.00 89.37 C \\\\nATOM 2831 O ASN A 357 -20.150 -11.488 -27.633 1.00 89.37 O \\\\nATOM 2832 CG ASN A 357 -22.604 -11.057 -23.936 1.00 89.37 C \\\\nATOM 2833 ND2 ASN A 357 -22.554 -10.217 -22.930 1.00 89.37 N \\\\nATOM 2834 OD1 ASN A 357 -23.262 -12.078 -23.847 1.00 89.37 O \\\\nATOM 2835 N GLN A 358 -18.487 -10.699 -26.346 1.00 91.08 N \\\\nATOM 2836 CA GLN A 358 -17.529 -10.374 -27.411 1.00 91.08 C \\\\nATOM 2837 C GLN A 358 -16.492 -11.499 -27.621 1.00 91.08 C \\\\nATOM 2838 CB GLN A 358 -16.841 -9.038 -27.074 1.00 91.08 C \\\\nATOM 2839 O GLN A 358 -15.707 -11.448 -28.566 1.00 91.08 O \\\\nATOM 2840 CG GLN A 358 -17.800 -7.840 -26.950 1.00 91.08 C \\\\nATOM 2841 CD GLN A 358 -17.139 -6.596 -26.353 1.00 91.08 C \\\\nATOM 2842 NE2 GLN A 358 -17.807 -5.465 -26.381 1.00 91.08 N \\\\nATOM 2843 OE1 GLN A 358 -16.049 -6.607 -25.801 1.00 91.08 O \\\\nATOM 2844 N GLY A 359 -16.494 -12.529 -26.765 1.00 90.37 N \\\\nATOM 2845 CA GLY A 359 -15.665 -13.728 -26.894 1.00 90.37 C \\\\nATOM 2846 C GLY A 359 -14.324 -13.684 -26.151 1.00 90.37 C \\\\nATOM 2847 O GLY A 359 -14.008 -12.750 -25.412 1.00 90.37 O \\\\nATOM 2848 N PHE A 360 -13.531 -14.747 -26.339 1.00 90.85 N \\\\nATOM 2849 CA PHE A 360 -12.313 -15.020 -25.561 1.00 90.85 C \\\\nATOM 2850 C PHE A 360 -11.310 -13.865 -25.550 1.00 90.85 C \\\\nATOM 2851 CB PHE A 360 -11.668 -16.329 -26.041 1.00 90.85 C \\\\nATOM 2852 O PHE A 360 -10.863 -13.465 -24.477 1.00 90.85 O \\\\nATOM 2853 CG PHE A 360 -10.561 -16.809 -25.121 1.00 90.85 C \\\\nATOM 2854 CD1 PHE A 360 -9.265 -16.267 -25.227 1.00 90.85 C \\\\nATOM 2855 CD2 PHE A 360 -10.837 -17.763 -24.121 1.00 90.85 C \\\\nATOM 2856 CE1 PHE A 360 -8.253 -16.670 -24.338 1.00 90.85 C \\\\nATOM 2857 CE2 PHE A 360 -9.824 -18.168 -23.234 1.00 90.85 C \\\\nATOM 2858 CZ PHE A 360 -8.532 -17.623 -23.343 1.00 90.85 C \\\\nATOM 2859 N GLU A 361 -10.982 -13.310 -26.717 1.00 91.71 N \\\\nATOM 2860 CA GLU A 361 -9.951 -12.274 -26.825 1.00 91.71 C \\\\nATOM 2861 C GLU A 361 -10.351 -10.987 -26.091 1.00 91.71 C \\\\nATOM 2862 CB GLU A 361 -9.656 -12.018 -28.313 1.00 91.71 C \\\\nATOM 2863 O GLU A 361 -9.552 -10.427 -25.345 1.00 91.71 O \\\\nATOM 2864 CG GLU A 361 -8.429 -11.123 -28.545 1.00 91.71 C \\\\nATOM 2865 CD GLU A 361 -7.154 -11.667 -27.883 1.00 91.71 C \\\\nATOM 2866 OE1 GLU A 361 -6.342 -10.831 -27.422 1.00 91.71 O \\\\nATOM 2867 OE2 GLU A 361 -7.010 -12.908 -27.800 1.00 91.71 O \\\\nATOM 2868 N ALA A 362 -11.613 -10.562 -26.213 1.00 93.21 N \\\\nATOM 2869 CA ALA A 362 -12.117 -9.369 -25.538 1.00 93.21 C \\\\nATOM 2870 C ALA A 362 -11.999 -9.481 -24.010 1.00 93.21 C \\\\nATOM 2871 CB ALA A 362 -13.566 -9.150 -25.973 1.00 93.21 C \\\\nATOM 2872 O ALA A 362 -11.527 -8.553 -23.355 1.00 93.21 O \\\\nATOM 2873 N VAL A 363 -12.357 -10.639 -23.441 1.00 93.93 N \\\\nATOM 2874 CA VAL A 363 -12.168 -10.907 -22.007 1.00 93.93 C \\\\nATOM 2875 C VAL A 363 -10.682 -11.016 -21.660 1.00 93.93 C \\\\nATOM 2876 CB VAL A 363 -12.953 -12.156 -21.569 1.00 93.93 C \\\\nATOM 2877 O VAL A 363 -10.252 -10.433 -20.670 1.00 93.93 O \\\\nATOM 2878 CG1 VAL A 363 -12.751 -12.502 -20.091 1.00 93.93 C \\\\nATOM 2879 CG2 VAL A 363 -14.456 -11.915 -21.749 1.00 93.93 C \\\\nATOM 2880 N TYR A 364 -9.862 -11.685 -22.472 1.00 93.20 N \\\\nATOM 2881 CA TYR A 364 -8.427 -11.825 -22.207 1.00 93.20 C \\\\nATOM 2882 C TYR A 364 -7.715 -10.462 -22.122 1.00 93.20 C \\\\nATOM 2883 CB TYR A 364 -7.800 -12.732 -23.272 1.00 93.20 C \\\\nATOM 2884 O TYR A 364 -6.920 -10.228 -21.204 1.00 93.20 O \\\\nATOM 2885 CG TYR A 364 -6.345 -13.042 -22.995 1.00 93.20 C \\\\nATOM 2886 CD1 TYR A 364 -5.330 -12.355 -23.688 1.00 93.20 C \\\\nATOM 2887 CD2 TYR A 364 -6.013 -13.994 -22.012 1.00 93.20 C \\\\nATOM 2888 CE1 TYR A 364 -3.979 -12.605 -23.380 1.00 93.20 C \\\\nATOM 2889 CE2 TYR A 364 -4.663 -14.253 -21.707 1.00 93.20 C \\\\nATOM 2890 OH TYR A 364 -2.341 -13.787 -22.088 1.00 93.20 O \\\\nATOM 2891 CZ TYR A 364 -3.645 -13.550 -22.388 1.00 93.20 C \\\\nATOM 2892 N GLN A 365 -8.072 -9.512 -22.994 1.00 93.42 N \\\\nATOM 2893 CA GLN A 365 -7.553 -8.140 -22.965 1.00 93.42 C \\\\nATOM 2894 C GLN A 365 -7.907 -7.379 -21.672 1.00 93.42 C \\\\nATOM 2895 CB GLN A 365 -8.040 -7.370 -24.206 1.00 93.42 C \\\\nATOM 2896 O GLN A 365 -7.131 -6.515 -21.249 1.00 93.42 O \\\\nATOM 2897 CG GLN A 365 -7.428 -7.884 -25.524 1.00 93.42 C \\\\nATOM 2898 CD GLN A 365 -5.914 -7.725 -25.629 1.00 93.42 C \\\\nATOM 2899 NE2 GLN A 365 -5.257 -8.548 -26.410 1.00 93.42 N \\\\nATOM 2900 OE1 GLN A 365 -5.283 -6.872 -25.015 1.00 93.42 O \\\\nATOM 2901 N LEU A 366 -8.993 -7.738 -20.967 1.00 95.17 N \\\\nATOM 2902 CA LEU A 366 -9.334 -7.145 -19.664 1.00 95.17 C \\\\nATOM 2903 C LEU A 366 -8.290 -7.423 -18.574 1.00 95.17 C \\\\nATOM 2904 CB LEU A 366 -10.722 -7.583 -19.165 1.00 95.17 C \\\\nATOM 2905 O LEU A 366 -8.277 -6.712 -17.570 1.00 95.17 O \\\\nATOM 2906 CG LEU A 366 -11.909 -7.249 -20.080 1.00 95.17 C \\\\nATOM 2907 CD1 LEU A 366 -13.200 -7.665 -19.379 1.00 95.17 C \\\\nATOM 2908 CD2 LEU A 366 -11.996 -5.757 -20.398 1.00 95.17 C \\\\nATOM 2909 N THR A 367 -7.352 -8.355 -18.783 1.00 95.31 N \\\\nATOM 2910 CA THR A 367 -6.177 -8.527 -17.907 1.00 95.31 C \\\\nATOM 2911 C THR A 367 -5.436 -7.198 -17.716 1.00 95.31 C \\\\nATOM 2912 CB THR A 367 -5.206 -9.573 -18.482 1.00 95.31 C \\\\nATOM 2913 O THR A 367 -5.001 -6.880 -16.610 1.00 95.31 O \\\\nATOM 2914 CG2 THR A 367 -4.080 -9.922 -17.507 1.00 95.31 C \\\\nATOM 2915 OG1 THR A 367 -5.878 -10.777 -18.753 1.00 95.31 O \\\\nATOM 2916 N ARG A 368 -5.376 -6.362 -18.767 1.00 94.06 N \\\\nATOM 2917 CA ARG A 368 -4.761 -5.024 -18.728 1.00 94.06 C \\\\nATOM 2918 C ARG A 368 -5.491 -4.059 -17.790 1.00 94.06 C \\\\nATOM 2919 CB ARG A 368 -4.712 -4.429 -20.146 1.00 94.06 C \\\\nATOM 2920 O ARG A 368 -4.845 -3.193 -17.211 1.00 94.06 O \\\\nATOM 2921 CG ARG A 368 -3.878 -5.258 -21.138 1.00 94.06 C \\\\nATOM 2922 CD ARG A 368 -3.914 -4.608 -22.527 1.00 94.06 C \\\\nATOM 2923 NE ARG A 368 -3.118 -5.365 -23.510 1.00 94.06 N \\\\nATOM 2924 NH1 ARG A 368 -3.408 -3.937 -25.296 1.00 94.06 N \\\\nATOM 2925 NH2 ARG A 368 -2.269 -5.831 -25.575 1.00 94.06 N \\\\nATOM 2926 CZ ARG A 368 -2.938 -5.042 -24.782 1.00 94.06 C \\\\nATOM 2927 N MET A 369 -6.806 -4.208 -17.603 1.00 95.92 N \\\\nATOM 2928 CA MET A 369 -7.591 -3.369 -16.685 1.00 95.92 C \\\\nATOM 2929 C MET A 369 -7.190 -3.597 -15.226 1.00 95.92 C \\\\nATOM 2930 CB MET A 369 -9.098 -3.637 -16.840 1.00 95.92 C \\\\nATOM 2931 O MET A 369 -7.254 -2.670 -14.421 1.00 95.92 O \\\\nATOM 2932 CG MET A 369 -9.631 -3.405 -18.258 1.00 95.92 C \\\\nATOM 2933 SD MET A 369 -9.534 -1.698 -18.853 1.00 95.92 S \\\\nATOM 2934 CE MET A 369 -10.858 -0.933 -17.889 1.00 95.92 C \\\\nATOM 2935 N CYS A 370 -6.756 -4.814 -14.892 1.00 97.33 N \\\\nATOM 2936 CA CYS A 370 -6.361 -5.210 -13.542 1.00 97.33 C \\\\nATOM 2937 C CYS A 370 -4.930 -4.783 -13.163 1.00 97.33 C \\\\nATOM 2938 CB CYS A 370 -6.520 -6.726 -13.419 1.00 97.33 C \\\\nATOM 2939 O CYS A 370 -4.534 -4.961 -12.006 1.00 97.33 O \\\\nATOM 2940 SG CYS A 370 -8.188 -7.266 -13.897 1.00 97.33 S \\\\nATOM 2941 N THR A 371 -4.166 -4.227 -14.112 1.00 97.75 N \\\\nATOM 2942 CA THR A 371 -2.799 -3.731 -13.912 1.00 97.75 C \\\\nATOM 2943 C THR A 371 -2.781 -2.203 -13.909 1.00 97.75 C \\\\nATOM 2944 CB THR A 371 -1.831 -4.295 -14.965 1.00 97.75 C \\\\nATOM 2945 O THR A 371 -3.195 -1.556 -14.869 1.00 97.75 O \\\\nATOM 2946 CG2 THR A 371 -0.398 -3.796 -14.784 1.00 97.75 C \\\\nATOM 2947 OG1 THR A 371 -1.781 -5.699 -14.867 1.00 97.75 O \\\\nATOM 2948 N ILE A 372 -2.257 -1.608 -12.836 1.00 98.54 N \\\\nATOM 2949 CA ILE A 372 -2.121 -0.152 -12.686 1.00 98.54 C \\\\nATOM 2950 C ILE A 372 -0.647 0.191 -12.503 1.00 98.54 C \\\\nATOM 2951 CB ILE A 372 -2.996 0.374 -11.525 1.00 98.54 C \\\\nATOM 2952 O ILE A 372 0.026 -0.382 -11.648 1.00 98.54 O \\\\nATOM 2953 CG1 ILE A 372 -4.488 0.075 -11.799 1.00 98.54 C \\\\nATOM 2954 CG2 ILE A 372 -2.745 1.881 -11.307 1.00 98.54 C \\\\nATOM 2955 CD1 ILE A 372 -5.428 0.435 -10.644 1.00 98.54 C \\\\nATOM 2956 N ARG A 373 -0.136 1.158 -13.267 1.00 98.65 N \\\\nATOM 2957 CA ARG A 373 1.268 1.590 -13.178 1.00 98.65 C \\\\nATOM 2958 C ARG A 373 1.374 2.972 -12.567 1.00 98.65 C \\\\nATOM 2959 CB ARG A 373 1.950 1.501 -14.547 1.00 98.65 C \\\\nATOM 2960 O ARG A 373 0.597 3.860 -12.919 1.00 98.65 O \\\\nATOM 2961 CG ARG A 373 1.956 0.049 -15.037 1.00 98.65 C \\\\nATOM 2962 CD ARG A 373 2.780 -0.093 -16.310 1.00 98.65 C \\\\nATOM 2963 NE ARG A 373 2.808 -1.498 -16.728 1.00 98.65 N \\\\nATOM 2964 NH1 ARG A 373 1.773 -1.380 -18.785 1.00 98.65 N \\\\nATOM 2965 NH2 ARG A 373 2.486 -3.339 -17.937 1.00 98.65 N \\\\nATOM 2966 CZ ARG A 373 2.352 -2.053 -17.828 1.00 98.65 C \\\\nATOM 2967 N MET A 374 2.340 3.170 -11.670 1.00 98.70 N \\\\nATOM 2968 CA MET A 374 2.595 4.475 -11.055 1.00 98.70 C \\\\nATOM 2969 C MET A 374 4.073 4.844 -11.050 1.00 98.70 C \\\\nATOM 2970 CB MET A 374 2.054 4.573 -9.625 1.00 98.70 C \\\\nATOM 2971 O MET A 374 4.883 4.113 -10.489 1.00 98.70 O \\\\nATOM 2972 CG MET A 374 0.607 4.118 -9.491 1.00 98.70 C \\\\nATOM 2973 SD MET A 374 -0.088 4.536 -7.879 1.00 98.70 S \\\\nATOM 2974 CE MET A 374 -1.719 3.823 -8.145 1.00 98.70 C \\\\nATOM 2975 N SER A 375 4.416 6.010 -11.595 1.00 98.78 N \\\\nATOM 2976 CA SER A 375 5.757 6.597 -11.498 1.00 98.78 C \\\\nATOM 2977 C SER A 375 5.819 7.646 -10.391 1.00 98.78 C \\\\nATOM 2978 CB SER A 375 6.193 7.202 -12.831 1.00 98.78 C \\\\nATOM 2979 O SER A 375 4.895 8.447 -10.214 1.00 98.78 O \\\\nATOM 2980 OG SER A 375 7.441 7.846 -12.697 1.00 98.78 O \\\\nATOM 2981 N PHE A 376 6.942 7.680 -9.677 1.00 98.81 N \\\\nATOM 2982 CA PHE A 376 7.247 8.703 -8.685 1.00 98.81 C \\\\nATOM 2983 C PHE A 376 8.044 9.849 -9.319 1.00 98.81 C \\\\nATOM 2984 CB PHE A 376 8.019 8.080 -7.515 1.00 98.81 C \\\\nATOM 2985 O PHE A 376 9.028 9.620 -10.023 1.00 98.81 O \\\\nATOM 2986 CG PHE A 376 7.275 6.993 -6.762 1.00 98.81 C \\\\nATOM 2987 CD1 PHE A 376 6.403 7.336 -5.711 1.00 98.81 C \\\\nATOM 2988 CD2 PHE A 376 7.459 5.639 -7.102 1.00 98.81 C \\\\nATOM 2989 CE1 PHE A 376 5.723 6.330 -5.001 1.00 98.81 C \\\\nATOM 2990 CE2 PHE A 376 6.777 4.635 -6.393 1.00 98.81 C \\\\nATOM 2991 CZ PHE A 376 5.910 4.979 -5.342 1.00 98.81 C \\\\nATOM 2992 N VAL A 377 7.682 11.099 -9.004 1.00 98.56 N \\\\nATOM 2993 CA VAL A 377 8.406 12.346 -9.346 1.00 98.56 C \\\\nATOM 2994 C VAL A 377 8.447 12.701 -10.843 1.00 98.56 C \\\\nATOM 2995 CB VAL A 377 9.846 12.335 -8.774 1.00 98.56 C \\\\nATOM 2996 O VAL A 377 8.438 13.885 -11.182 1.00 98.56 O \\\\nATOM 2997 CG1 VAL A 377 10.498 13.724 -8.771 1.00 98.56 C \\\\nATOM 2998 CG2 VAL A 377 9.970 11.778 -7.346 1.00 98.56 C \\\\nATOM 2999 N LYS A 378 8.509 11.725 -11.758 1.00 98.24 N \\\\nATOM 3000 CA LYS A 378 8.670 11.928 -13.209 1.00 98.24 C \\\\nATOM 3001 C LYS A 378 7.483 11.353 -13.989 1.00 98.24 C \\\\nATOM 3002 CB LYS A 378 9.996 11.299 -13.693 1.00 98.24 C \\\\nATOM 3003 O LYS A 378 7.233 10.155 -13.919 1.00 98.24 O \\\\nATOM 3004 CG LYS A 378 11.266 11.754 -12.948 1.00 98.24 C \\\\nATOM 3005 CD LYS A 378 11.501 13.272 -12.973 1.00 98.24 C \\\\nATOM 3006 CE LYS A 378 12.773 13.608 -12.185 1.00 98.24 C \\\\nATOM 3007 NZ LYS A 378 12.933 15.073 -12.002 1.00 98.24 N \\\\nATOM 3008 N GLY A 379 6.803 12.192 -14.767 1.00 97.29 N \\\\nATOM 3009 CA GLY A 379 5.748 11.760 -15.689 1.00 97.29 C \\\\nATOM 3010 C GLY A 379 6.277 11.053 -16.939 1.00 97.29 C \\\\nATOM 3011 O GLY A 379 7.464 11.159 -17.273 1.00 97.29 O \\\\nATOM 3012 N TRP A 380 5.368 10.348 -17.612 1.00 98.27 N \\\\nATOM 3013 CA TRP A 380 5.543 9.736 -18.930 1.00 98.27 C \\\\nATOM 3014 C TRP A 380 4.223 9.790 -19.721 1.00 98.27 C \\\\nATOM 3015 CB TRP A 380 6.049 8.290 -18.793 1.00 98.27 C \\\\nATOM 3016 O TRP A 380 3.188 10.128 -19.148 1.00 98.27 O \\\\nATOM 3017 CG TRP A 380 5.001 7.249 -18.540 1.00 98.27 C \\\\nATOM 3018 CD1 TRP A 380 4.437 6.468 -19.491 1.00 98.27 C \\\\nATOM 3019 CD2 TRP A 380 4.327 6.901 -17.293 1.00 98.27 C \\\\nATOM 3020 CE2 TRP A 380 3.395 5.855 -17.564 1.00 98.27 C \\\\nATOM 3021 CE3 TRP A 380 4.395 7.369 -15.962 1.00 98.27 C \\\\nATOM 3022 NE1 TRP A 380 3.495 5.638 -18.919 1.00 98.27 N \\\\nATOM 3023 CH2 TRP A 380 2.678 5.771 -15.259 1.00 98.27 C \\\\nATOM 3024 CZ2 TRP A 380 2.605 5.271 -16.567 1.00 98.27 C \\\\nATOM 3025 CZ3 TRP A 380 3.563 6.822 -14.967 1.00 98.27 C \\\\nATOM 3026 N GLY A 381 4.259 9.453 -21.010 1.00 95.83 N \\\\nATOM 3027 CA GLY A 381 3.134 9.560 -21.944 1.00 95.83 C \\\\nATOM 3028 C GLY A 381 3.169 10.863 -22.749 1.00 95.83 C \\\\nATOM 3029 O GLY A 381 4.135 11.616 -22.647 1.00 95.83 O \\\\nATOM 3030 N ALA A 382 2.109 11.126 -23.522 1.00 92.96 N \\\\nATOM 3031 CA ALA A 382 2.044 12.198 -24.528 1.00 92.96 C \\\\nATOM 3032 C ALA A 382 2.542 13.575 -24.035 1.00 92.96 C \\\\nATOM 3033 CB ALA A 382 0.592 12.282 -25.020 1.00 92.96 C \\\\nATOM 3034 O ALA A 382 3.350 14.214 -24.702 1.00 92.96 O \\\\nATOM 3035 N GLU A 383 2.152 13.976 -22.821 1.00 91.46 N \\\\nATOM 3036 CA GLU A 383 2.499 15.270 -22.206 1.00 91.46 C \\\\nATOM 3037 C GLU A 383 3.948 15.372 -21.678 1.00 91.46 C \\\\nATOM 3038 CB GLU A 383 1.507 15.559 -21.063 1.00 91.46 C \\\\nATOM 3039 O GLU A 383 4.318 16.347 -21.019 1.00 91.46 O \\\\nATOM 3040 CG GLU A 383 0.031 15.522 -21.482 1.00 91.46 C \\\\nATOM 3041 CD GLU A 383 -0.228 16.402 -22.707 1.00 91.46 C \\\\nATOM 3042 OE1 GLU A 383 -0.810 15.863 -23.671 1.00 91.46 O \\\\nATOM 3043 OE2 GLU A 383 0.203 17.575 -22.659 1.00 91.46 O \\\\nATOM 3044 N TYR A 384 4.787 14.351 -21.888 1.00 95.61 N \\\\nATOM 3045 CA TYR A 384 6.121 14.262 -21.297 1.00 95.61 C \\\\nATOM 3046 C TYR A 384 7.166 13.757 -22.295 1.00 95.61 C \\\\nATOM 3047 CB TYR A 384 6.084 13.357 -20.051 1.00 95.61 C \\\\nATOM 3048 O TYR A 384 6.925 12.880 -23.113 1.00 95.61 O \\\\nATOM 3049 CG TYR A 384 5.120 13.811 -18.968 1.00 95.61 C \\\\nATOM 3050 CD1 TYR A 384 5.477 14.837 -18.069 1.00 95.61 C \\\\nATOM 3051 CD2 TYR A 384 3.824 13.267 -18.924 1.00 95.61 C \\\\nATOM 3052 CE1 TYR A 384 4.523 15.344 -17.162 1.00 95.61 C \\\\nATOM 3053 CE2 TYR A 384 2.872 13.758 -18.015 1.00 95.61 C \\\\nATOM 3054 OH TYR A 384 2.248 15.383 -16.376 1.00 95.61 O \\\\nATOM 3055 CZ TYR A 384 3.208 14.827 -17.161 1.00 95.61 C \\\\nATOM 3056 N ARG A 385 8.418 14.209 -22.132 1.00 95.60 N \\\\nATOM 3057 CA ARG A 385 9.572 13.721 -22.919 1.00 95.60 C \\\\nATOM 3058 C ARG A 385 9.787 12.195 -22.835 1.00 95.60 C \\\\nATOM 3059 CB ARG A 385 10.822 14.516 -22.492 1.00 95.60 C \\\\nATOM 3060 O ARG A 385 10.451 11.618 -23.689 1.00 95.60 O \\\\nATOM 3061 CG ARG A 385 12.085 14.098 -23.262 1.00 95.60 C \\\\nATOM 3062 CD ARG A 385 13.284 15.003 -22.977 1.00 95.60 C \\\\nATOM 3063 NE ARG A 385 14.513 14.388 -23.516 1.00 95.60 N \\\\nATOM 3064 NH1 ARG A 385 15.973 15.009 -21.858 1.00 95.60 N \\\\nATOM 3065 NH2 ARG A 385 16.623 13.531 -23.347 1.00 95.60 N \\\\nATOM 3066 CZ ARG A 385 15.687 14.316 -22.919 1.00 95.60 C \\\\nATOM 3067 N ARG A 386 9.276 11.538 -21.790 1.00 96.56 N \\\\nATOM 3068 CA ARG A 386 9.328 10.080 -21.615 1.00 96.56 C \\\\nATOM 3069 C ARG A 386 8.064 9.473 -22.206 1.00 96.56 C \\\\nATOM 3070 CB ARG A 386 9.416 9.737 -20.120 1.00 96.56 C \\\\nATOM 3071 O ARG A 386 7.011 9.641 -21.612 1.00 96.56 O \\\\nATOM 3072 CG ARG A 386 10.779 10.093 -19.533 1.00 96.56 C \\\\nATOM 3073 CD ARG A 386 10.772 9.857 -18.020 1.00 96.56 C \\\\nATOM 3074 NE ARG A 386 12.126 10.031 -17.471 1.00 96.56 N \\\\nATOM 3075 NH1 ARG A 386 12.152 12.322 -17.440 1.00 96.56 N \\\\nATOM 3076 NH2 ARG A 386 14.040 11.183 -17.055 1.00 96.56 N \\\\nATOM 3077 CZ ARG A 386 12.764 11.175 -17.316 1.00 96.56 C \\\\nATOM 3078 N GLN A 387 8.162 8.731 -23.303 1.00 96.27 N \\\\nATOM 3079 CA GLN A 387 6.978 8.072 -23.868 1.00 96.27 C \\\\nATOM 3080 C GLN A 387 6.599 6.798 -23.101 1.00 96.27 C \\\\nATOM 3081 CB GLN A 387 7.175 7.829 -25.375 1.00 96.27 C \\\\nATOM 3082 O GLN A 387 5.418 6.542 -22.877 1.00 96.27 O \\\\nATOM 3083 CG GLN A 387 7.368 9.140 -26.168 1.00 96.27 C \\\\nATOM 3084 CD GLN A 387 6.268 10.168 -25.894 1.00 96.27 C \\\\nATOM 3085 NE2 GLN A 387 6.591 11.439 -25.828 1.00 96.27 N \\\\nATOM 3086 OE1 GLN A 387 5.116 9.840 -25.663 1.00 96.27 O \\\\nATOM 3087 N THR A 388 7.585 6.039 -22.609 1.00 96.77 N \\\\nATOM 3088 CA THR A 388 7.359 4.769 -21.901 1.00 96.77 C \\\\nATOM 3089 C THR A 388 7.482 4.891 -20.379 1.00 96.77 C \\\\nATOM 3090 CB THR A 388 8.262 3.641 -22.424 1.00 96.77 C \\\\nATOM 3091 O THR A 388 8.281 5.683 -19.868 1.00 96.77 O \\\\nATOM 3092 CG2 THR A 388 8.328 3.568 -23.951 1.00 96.77 C \\\\nATOM 3093 OG1 THR A 388 9.576 3.812 -21.939 1.00 96.77 O \\\\nATOM 3094 N VAL A 389 6.756 4.048 -19.633 1.00 97.45 N \\\\nATOM 3095 CA VAL A 389 6.912 3.957 -18.167 1.00 97.45 C \\\\nATOM 3096 C VAL A 389 8.310 3.454 -17.785 1.00 97.45 C \\\\nATOM 3097 CB VAL A 389 5.801 3.086 -17.550 1.00 97.45 C \\\\nATOM 3098 O VAL A 389 8.912 3.944 -16.831 1.00 97.45 O \\\\nATOM 3099 CG1 VAL A 389 5.955 1.595 -17.873 1.00 97.45 C \\\\nATOM 3100 CG2 VAL A 389 5.724 3.294 -16.035 1.00 97.45 C \\\\nATOM 3101 N THR A 390 8.887 2.575 -18.610 1.00 97.99 N \\\\nATOM 3102 CA THR A 390 10.258 2.053 -18.489 1.00 97.99 C \\\\nATOM 3103 C THR A 390 11.346 3.119 -18.676 1.00 97.99 C \\\\nATOM 3104 CB THR A 390 10.484 0.908 -19.489 1.00 97.99 C \\\\nATOM 3105 O THR A 390 12.499 2.887 -18.328 1.00 97.99 O \\\\nATOM 3106 CG2 THR A 390 9.628 -0.312 -19.156 1.00 97.99 C \\\\nATOM 3107 OG1 THR A 390 10.131 1.299 -20.801 1.00 97.99 O \\\\nATOM 3108 N SER A 391 10.993 4.315 -19.163 1.00 97.57 N \\\\nATOM 3109 CA SER A 391 11.880 5.488 -19.190 1.00 97.57 C \\\\nATOM 3110 C SER A 391 11.865 6.287 -17.876 1.00 97.57 C \\\\nATOM 3111 CB SER A 391 11.491 6.413 -20.347 1.00 97.57 C \\\\nATOM 3112 O SER A 391 12.628 7.250 -17.716 1.00 97.57 O \\\\nATOM 3113 OG SER A 391 11.570 5.771 -21.600 1.00 97.57 O \\\\nATOM 3114 N THR A 392 10.972 5.959 -16.936 1.00 98.21 N \\\\nATOM 3115 CA THR A 392 10.876 6.643 -15.639 1.00 98.21 C \\\\nATOM 3116 C THR A 392 11.872 6.052 -14.631 1.00 98.21 C \\\\nATOM 3117 CB THR A 392 9.458 6.672 -15.051 1.00 98.21 C \\\\nATOM 3118 O THR A 392 12.089 4.840 -14.616 1.00 98.21 O \\\\nATOM 3119 CG2 THR A 392 8.388 7.194 -16.015 1.00 98.21 C \\\\nATOM 3120 OG1 THR A 392 9.084 5.412 -14.573 1.00 98.21 O \\\\nATOM 3121 N PRO A 393 12.518 6.866 -13.771 1.00 98.48 N \\\\nATOM 3122 CA PRO A 393 13.592 6.349 -12.921 1.00 98.48 C \\\\nATOM 3123 C PRO A 393 13.100 5.443 -11.783 1.00 98.48 C \\\\nATOM 3124 CB PRO A 393 14.326 7.582 -12.381 1.00 98.48 C \\\\nATOM 3125 O PRO A 393 13.865 4.617 -11.299 1.00 98.48 O \\\\nATOM 3126 CG PRO A 393 13.897 8.717 -13.306 1.00 98.48 C \\\\nATOM 3127 CD PRO A 393 12.477 8.318 -13.683 1.00 98.48 C \\\\nATOM 3128 N CYS A 394 11.856 5.613 -11.327 1.00 98.74 N \\\\nATOM 3129 CA CYS A 394 11.266 4.879 -10.207 1.00 98.74 C \\\\nATOM 3130 C CYS A 394 9.761 4.723 -10.431 1.00 98.74 C \\\\nATOM 3131 CB CYS A 394 11.484 5.670 -8.905 1.00 98.74 C \\\\nATOM 3132 O CYS A 394 9.036 5.719 -10.370 1.00 98.74 O \\\\nATOM 3133 SG CYS A 394 13.241 5.820 -8.497 1.00 98.74 S \\\\nATOM 3134 N TRP A 395 9.288 3.495 -10.619 1.00 98.82 N \\\\nATOM 3135 CA TRP A 395 7.864 3.208 -10.776 1.00 98.82 C \\\\nATOM 3136 C TRP A 395 7.477 1.861 -10.162 1.00 98.82 C \\\\nATOM 3137 CB TRP A 395 7.465 3.314 -12.257 1.00 98.82 C \\\\nATOM 3138 O TRP A 395 8.329 1.046 -9.813 1.00 98.82 O \\\\nATOM 3139 CG TRP A 395 8.092 2.330 -13.189 1.00 98.82 C \\\\nATOM 3140 CD1 TRP A 395 9.343 2.411 -13.690 1.00 98.82 C \\\\nATOM 3141 CD2 TRP A 395 7.504 1.123 -13.769 1.00 98.82 C \\\\nATOM 3142 CE2 TRP A 395 8.473 0.520 -14.624 1.00 98.82 C \\\\nATOM 3143 CE3 TRP A 395 6.250 0.480 -13.671 1.00 98.82 C \\\\nATOM 3144 NE1 TRP A 395 9.567 1.348 -14.535 1.00 98.82 N \\\\nATOM 3145 CH2 TRP A 395 6.985 -1.301 -15.179 1.00 98.82 C \\\\nATOM 3146 CZ2 TRP A 395 8.237 -0.677 -15.311 1.00 98.82 C \\\\nATOM 3147 CZ3 TRP A 395 5.993 -0.713 -14.374 1.00 98.82 C \\\\nATOM 3148 N ILE A 396 6.178 1.660 -9.978 1.00 98.81 N \\\\nATOM 3149 CA ILE A 396 5.573 0.439 -9.447 1.00 98.81 C \\\\nATOM 3150 C ILE A 396 4.464 -0.057 -10.370 1.00 98.81 C \\\\nATOM 3151 CB ILE A 396 5.055 0.618 -7.998 1.00 98.81 C \\\\nATOM 3152 O ILE A 396 3.745 0.736 -10.983 1.00 98.81 O \\\\nATOM 3153 CG1 ILE A 396 4.207 1.900 -7.835 1.00 98.81 C \\\\nATOM 3154 CG2 ILE A 396 6.250 0.602 -7.030 1.00 98.81 C \\\\nATOM 3155 CD1 ILE A 396 3.470 2.058 -6.498 1.00 98.81 C \\\\nATOM 3156 N GLU A 397 4.315 -1.374 -10.421 1.00 98.72 N \\\\nATOM 3157 CA GLU A 397 3.209 -2.078 -11.062 1.00 98.72 C \\\\nATOM 3158 C GLU A 397 2.344 -2.726 -9.976 1.00 98.72 C \\\\nATOM 3159 CB GLU A 397 3.781 -3.100 -12.056 1.00 98.72 C \\\\nATOM 3160 O GLU A 397 2.847 -3.509 -9.169 1.00 98.72 O \\\\nATOM 3161 CG GLU A 397 2.709 -3.684 -12.983 1.00 98.72 C \\\\nATOM 3162 CD GLU A 397 3.354 -4.370 -14.196 1.00 98.72 C \\\\nATOM 3163 OE1 GLU A 397 4.027 -5.404 -14.009 1.00 98.72 O \\\\nATOM 3164 OE2 GLU A 397 3.229 -3.803 -15.313 1.00 98.72 O \\\\nATOM 3165 N LEU A 398 1.064 -2.356 -9.931 1.00 98.36 N \\\\nATOM 3166 CA LEU A 398 0.030 -2.936 -9.076 1.00 98.36 C \\\\nATOM 3167 C LEU A 398 -0.766 -3.952 -9.890 1.00 98.36 C \\\\nATOM 3168 CB LEU A 398 -0.960 -1.852 -8.600 1.00 98.36 C \\\\nATOM 3169 O LEU A 398 -1.309 -3.596 -10.934 1.00 98.36 O \\\\nATOM 3170 CG LEU A 398 -0.604 -1.058 -7.342 1.00 98.36 C \\\\nATOM 3171 CD1 LEU A 398 0.694 -0.268 -7.468 1.00 98.36 C \\\\nATOM 3172 CD2 LEU A 398 -1.738 -0.065 -7.071 1.00 98.36 C \\\\nATOM 3173 N HIS A 399 -0.933 -5.157 -9.358 1.00 98.32 N \\\\nATOM 3174 CA HIS A 399 -1.912 -6.134 -9.832 1.00 98.32 C \\\\nATOM 3175 C HIS A 399 -3.045 -6.261 -8.817 1.00 98.32 C \\\\nATOM 3176 CB HIS A 399 -1.212 -7.476 -10.077 1.00 98.32 C \\\\nATOM 3177 O HIS A 399 -2.795 -6.535 -7.642 1.00 98.32 O \\\\nATOM 3178 CG HIS A 399 -0.309 -7.495 -11.284 1.00 98.32 C \\\\nATOM 3179 CD2 HIS A 399 -0.246 -6.557 -12.278 1.00 98.32 C \\\\nATOM 3180 ND1 HIS A 399 0.574 -8.494 -11.622 1.00 98.32 N \\\\nATOM 3181 CE1 HIS A 399 1.150 -8.160 -12.792 1.00 98.32 C \\\\nATOM 3182 NE2 HIS A 399 0.669 -6.989 -13.236 1.00 98.32 N \\\\nATOM 3183 N LEU A 400 -4.286 -6.050 -9.260 1.00 98.07 N \\\\nATOM 3184 CA LEU A 400 -5.481 -6.181 -8.426 1.00 98.07 C \\\\nATOM 3185 C LEU A 400 -5.967 -7.633 -8.445 1.00 98.07 C \\\\nATOM 3186 CB LEU A 400 -6.556 -5.184 -8.888 1.00 98.07 C \\\\nATOM 3187 O LEU A 400 -6.554 -8.105 -9.419 1.00 98.07 O \\\\nATOM 3188 CG LEU A 400 -6.121 -3.708 -8.840 1.00 98.07 C \\\\nATOM 3189 CD1 LEU A 400 -7.303 -2.837 -9.244 1.00 98.07 C \\\\nATOM 3190 CD2 LEU A 400 -5.657 -3.258 -7.451 1.00 98.07 C \\\\nATOM 3191 N ASN A 401 -5.706 -8.350 -7.354 1.00 97.27 N \\\\nATOM 3192 CA ASN A 401 -5.823 -9.807 -7.309 1.00 97.27 C \\\\nATOM 3193 C ASN A 401 -7.278 -10.291 -7.399 1.00 97.27 C \\\\nATOM 3194 CB ASN A 401 -5.159 -10.310 -6.019 1.00 97.27 C \\\\nATOM 3195 O ASN A 401 -7.529 -11.344 -7.975 1.00 97.27 O \\\\nATOM 3196 CG ASN A 401 -3.660 -10.068 -5.942 1.00 97.27 C \\\\nATOM 3197 ND2 ASN A 401 -3.127 -10.033 -4.747 1.00 97.27 N \\\\nATOM 3198 OD1 ASN A 401 -2.948 -9.899 -6.917 1.00 97.27 O \\\\nATOM 3199 N GLY A 402 -8.237 -9.532 -6.858 1.00 95.66 N \\\\nATOM 3200 CA GLY A 402 -9.663 -9.875 -6.913 1.00 95.66 C \\\\nATOM 3201 C GLY A 402 -10.217 -9.810 -8.341 1.00 95.66 C \\\\nATOM 3202 O GLY A 402 -10.705 -10.824 -8.843 1.00 95.66 O \\\\nATOM 3203 N PRO A 403 -10.083 -8.665 -9.040 1.00 96.62 N \\\\nATOM 3204 CA PRO A 403 -10.371 -8.549 -10.469 1.00 96.62 C \\\\nATOM 3205 C PRO A 403 -9.676 -9.615 -11.333 1.00 96.62 C \\\\nATOM 3206 CB PRO A 403 -9.945 -7.123 -10.839 1.00 96.62 C \\\\nATOM 3207 O PRO A 403 -10.339 -10.236 -12.160 1.00 96.62 O \\\\nATOM 3208 CG PRO A 403 -10.232 -6.348 -9.555 1.00 96.62 C \\\\nATOM 3209 CD PRO A 403 -9.818 -7.347 -8.476 1.00 96.62 C \\\\nATOM 3210 N LEU A 404 -8.385 -9.904 -11.099 1.00 96.80 N \\\\nATOM 3211 CA LEU A 404 -7.666 -10.983 -11.798 1.00 96.80 C \\\\nATOM 3212 C LEU A 404 -8.263 -12.371 -11.528 1.00 96.80 C \\\\nATOM 3213 CB LEU A 404 -6.174 -10.983 -11.410 1.00 96.80 C \\\\nATOM 3214 O LEU A 404 -8.483 -13.127 -12.468 1.00 96.80 O \\\\nATOM 3215 CG LEU A 404 -5.348 -9.857 -12.047 1.00 96.80 C \\\\nATOM 3216 CD1 LEU A 404 -3.952 -9.816 -11.431 1.00 96.80 C \\\\nATOM 3217 CD2 LEU A 404 -5.193 -10.022 -13.561 1.00 96.80 C \\\\nATOM 3218 N GLN A 405 -8.560 -12.711 -10.271 1.00 94.96 N \\\\nATOM 3219 CA GLN A 405 -9.154 -14.005 -9.921 1.00 94.96 C \\\\nATOM 3220 C GLN A 405 -10.559 -14.168 -10.515 1.00 94.96 C \\\\nATOM 3221 CB GLN A 405 -9.194 -14.155 -8.390 1.00 94.96 C \\\\nATOM 3222 O GLN A 405 -10.961 -15.273 -10.878 1.00 94.96 O \\\\nATOM 3223 CG GLN A 405 -9.640 -15.569 -7.985 1.00 94.96 C \\\\nATOM 3224 CD GLN A 405 -9.740 -15.779 -6.480 1.00 94.96 C \\\\nATOM 3225 NE2 GLN A 405 -9.435 -16.962 -5.997 1.00 94.96 N \\\\nATOM 3226 OE1 GLN A 405 -10.159 -14.935 -5.711 1.00 94.96 O \\\\nATOM 3227 N TRP A 406 -11.330 -13.084 -10.611 1.00 94.76 N \\\\nATOM 3228 CA TRP A 406 -12.641 -13.131 -11.250 1.00 94.76 C \\\\nATOM 3229 C TRP A 406 -12.522 -13.339 -12.760 1.00 94.76 C \\\\nATOM 3230 CB TRP A 406 -13.421 -11.861 -10.921 1.00 94.76 C \\\\nATOM 3231 O TRP A 406 -13.245 -14.162 -13.318 1.00 94.76 O \\\\nATOM 3232 CG TRP A 406 -14.901 -11.926 -11.139 1.00 94.76 C \\\\nATOM 3233 CD1 TRP A 406 -15.639 -13.020 -11.452 1.00 94.76 C \\\\nATOM 3234 CD2 TRP A 406 -15.853 -10.833 -11.027 1.00 94.76 C \\\\nATOM 3235 CE2 TRP A 406 -17.167 -11.362 -11.172 1.00 94.76 C \\\\nATOM 3236 CE3 TRP A 406 -15.734 -9.448 -10.788 1.00 94.76 C \\\\nATOM 3237 NE1 TRP A 406 -16.980 -12.692 -11.466 1.00 94.76 N \\\\nATOM 3238 CH2 TRP A 406 -18.161 -9.205 -10.753 1.00 94.76 C \\\\nATOM 3239 CZ2 TRP A 406 -18.308 -10.573 -11.020 1.00 94.76 C \\\\nATOM 3240 CZ3 TRP A 406 -16.875 -8.643 -10.643 1.00 94.76 C \\\\nATOM 3241 N LEU A 407 -11.569 -12.651 -13.393 1.00 95.07 N \\\\nATOM 3242 CA LEU A 407 -11.270 -12.788 -14.812 1.00 95.07 C \\\\nATOM 3243 C LEU A 407 -10.824 -14.213 -15.175 1.00 95.07 C \\\\nATOM 3244 CB LEU A 407 -10.192 -11.749 -15.164 1.00 95.07 C \\\\nATOM 3245 O LEU A 407 -11.353 -14.798 -16.115 1.00 95.07 O \\\\nATOM 3246 CG LEU A 407 -9.929 -11.642 -16.669 1.00 95.07 C \\\\nATOM 3247 CD1 LEU A 407 -11.149 -11.068 -17.375 1.00 95.07 C \\\\nATOM 3248 CD2 LEU A 407 -8.748 -10.715 -16.923 1.00 95.07 C \\\\nATOM 3249 N ASP A 408 -9.917 -14.797 -14.390 1.00 93.11 N \\\\nATOM 3250 CA ASP A 408 -9.437 -16.178 -14.539 1.00 93.11 C \\\\nATOM 3251 C ASP A 408 -10.587 -17.204 -14.477 1.00 93.11 C \\\\nATOM 3252 CB ASP A 408 -8.399 -16.419 -13.435 1.00 93.11 C \\\\nATOM 3253 O ASP A 408 -10.728 -18.059 -15.355 1.00 93.11 O \\\\nATOM 3254 CG ASP A 408 -7.860 -17.847 -13.445 1.00 93.11 C \\\\nATOM 3255 OD1 ASP A 408 -7.091 -18.163 -14.378 1.00 93.11 O \\\\nATOM 3256 OD2 ASP A 408 -8.220 -18.594 -12.507 1.00 93.11 O \\\\nATOM 3257 N LYS A 409 -11.502 -17.057 -13.508 1.00 92.52 N \\\\nATOM 3258 CA LYS A 409 -12.709 -17.897 -13.397 1.00 92.52 C \\\\nATOM 3259 C LYS A 409 -13.689 -17.758 -14.570 1.00 92.52 C \\\\nATOM 3260 CB LYS A 409 -13.466 -17.549 -12.121 1.00 92.52 C \\\\nATOM 3261 O LYS A 409 -14.478 -18.674 -14.795 1.00 92.52 O \\\\nATOM 3262 CG LYS A 409 -12.815 -18.012 -10.816 1.00 92.52 C \\\\nATOM 3263 CD LYS A 409 -13.636 -17.364 -9.697 1.00 92.52 C \\\\nATOM 3264 CE LYS A 409 -13.255 -17.844 -8.303 1.00 92.52 C \\\\nATOM 3265 NZ LYS A 409 -14.099 -17.132 -7.314 1.00 92.52 N \\\\nATOM 3266 N VAL A 410 -13.695 -16.619 -15.268 1.00 92.90 N \\\\nATOM 3267 CA VAL A 410 -14.493 -16.418 -16.489 1.00 92.90 C \\\\nATOM 3268 C VAL A 410 -13.777 -17.046 -17.685 1.00 92.90 C \\\\nATOM 3269 CB VAL A 410 -14.818 -14.925 -16.709 1.00 92.90 C \\\\nATOM 3270 O VAL A 410 -14.371 -17.866 -18.380 1.00 92.90 O \\\\nATOM 3271 CG1 VAL A 410 -15.438 -14.649 -18.082 1.00 92.90 C \\\\nATOM 3272 CG2 VAL A 410 -15.821 -14.432 -15.656 1.00 92.90 C \\\\nATOM 3273 N LEU A 411 -12.490 -16.743 -17.889 1.00 91.89 N \\\\nATOM 3274 CA LEU A 411 -11.679 -17.284 -18.988 1.00 91.89 C \\\\nATOM 3275 C LEU A 411 -11.652 -18.818 -18.994 1.00 91.89 C \\\\nATOM 3276 CB LEU A 411 -10.248 -16.723 -18.887 1.00 91.89 C \\\\nATOM 3277 O LEU A 411 -11.850 -19.428 -20.042 1.00 91.89 O \\\\nATOM 3278 CG LEU A 411 -10.117 -15.253 -19.320 1.00 91.89 C \\\\nATOM 3279 CD1 LEU A 411 -8.733 -14.724 -18.945 1.00 91.89 C \\\\nATOM 3280 CD2 LEU A 411 -10.290 -15.094 -20.834 1.00 91.89 C \\\\nATOM 3281 N THR A 412 -11.507 -19.444 -17.823 1.00 89.09 N \\\\nATOM 3282 CA THR A 412 -11.554 -20.911 -17.663 1.00 89.09 C \\\\nATOM 3283 C THR A 412 -12.888 -21.550 -18.070 1.00 89.09 C \\\\nATOM 3284 CB THR A 412 -11.218 -21.336 -16.222 1.00 89.09 C \\\\nATOM 3285 O THR A 412 -12.927 -22.757 -18.300 1.00 89.09 O \\\\nATOM 3286 CG2 THR A 412 -9.732 -21.190 -15.906 1.00 89.09 C \\\\nATOM 3287 OG1 THR A 412 -11.912 -20.558 -15.277 1.00 89.09 O \\\\nATOM 3288 N GLN A 413 -13.972 -20.775 -18.201 1.00 86.81 N \\\\nATOM 3289 CA GLN A 413 -15.280 -21.252 -18.672 1.00 86.81 C \\\\nATOM 3290 C GLN A 413 -15.551 -20.940 -20.153 1.00 86.81 C \\\\nATOM 3291 CB GLN A 413 -16.392 -20.705 -17.761 1.00 86.81 C \\\\nATOM 3292 O GLN A 413 -16.411 -21.583 -20.748 1.00 86.81 O \\\\nATOM 3293 CG GLN A 413 -16.258 -21.285 -16.347 1.00 86.81 C \\\\nATOM 3294 CD GLN A 413 -17.349 -20.835 -15.387 1.00 86.81 C \\\\nATOM 3295 NE2 GLN A 413 -17.067 -20.833 -14.103 1.00 86.81 N \\\\nATOM 3296 OE1 GLN A 413 -18.474 -20.520 -15.728 1.00 86.81 O \\\\nATOM 3297 N MET A 414 -14.802 -20.018 -20.773 1.00 85.54 N \\\\nATOM 3298 CA MET A 414 -14.980 -19.637 -22.185 1.00 85.54 C \\\\nATOM 3299 C MET A 414 -14.133 -20.455 -23.177 1.00 85.54 C \\\\nATOM 3300 CB MET A 414 -14.761 -18.132 -22.380 1.00 85.54 C \\\\nATOM 3301 O MET A 414 -14.115 -20.160 -24.369 1.00 85.54 O \\\\nATOM 3302 CG MET A 414 -15.737 -17.300 -21.541 1.00 85.54 C \\\\nATOM 3303 SD MET A 414 -15.963 -15.552 -21.980 1.00 85.54 S \\\\nATOM 3304 CE MET A 414 -14.405 -15.179 -22.806 1.00 85.54 C \\\\nATOM 3305 N GLY A 415 -13.432 -21.496 -22.723 1.00 82.14 N \\\\nATOM 3306 CA GLY A 415 -12.658 -22.373 -23.604 1.00 82.14 C \\\\nATOM 3307 C GLY A 415 -11.343 -21.744 -24.076 1.00 82.14 C \\\\nATOM 3308 O GLY A 415 -10.474 -21.450 -23.260 1.00 82.14 O \\\\nATOM 3309 N SER A 416 -11.159 -21.607 -25.392 1.00 81.44 N \\\\nATOM 3310 CA SER A 416 -9.897 -21.178 -26.015 1.00 81.44 C \\\\nATOM 3311 C SER A 416 -10.125 -20.213 -27.186 1.00 81.44 C \\\\nATOM 3312 CB SER A 416 -9.114 -22.408 -26.502 1.00 81.44 C \\\\nATOM 3313 O SER A 416 -11.213 -20.226 -27.766 1.00 81.44 O \\\\nATOM 3314 OG SER A 416 -9.784 -23.090 -27.551 1.00 81.44 O \\\\nATOM 3315 N PRO A 417 -9.103 -19.446 -27.618 1.00 82.09 N \\\\nATOM 3316 CA PRO A 417 -9.158 -18.678 -28.861 1.00 82.09 C \\\\nATOM 3317 C PRO A 417 -9.571 -19.530 -30.072 1.00 82.09 C \\\\nATOM 3318 CB PRO A 417 -7.753 -18.096 -29.059 1.00 82.09 C \\\\nATOM 3319 O PRO A 417 -9.239 -20.715 -30.158 1.00 82.09 O \\\\nATOM 3320 CG PRO A 417 -7.186 -18.034 -27.644 1.00 82.09 C \\\\nATOM 3321 CD PRO A 417 -7.814 -19.252 -26.967 1.00 82.09 C \\\\nATOM 3322 N SER A 418 -10.262 -18.910 -31.031 1.00 80.99 N \\\\nATOM 3323 CA SER A 418 -10.662 -19.545 -32.296 1.00 80.99 C \\\\nATOM 3324 C SER A 418 -9.466 -19.816 -33.218 1.00 80.99 C \\\\nATOM 3325 CB SER A 418 -11.680 -18.649 -33.011 1.00 80.99 C \\\\nATOM 3326 O SER A 418 -9.413 -20.846 -33.893 1.00 80.99 O \\\\nATOM 3327 OG SER A 418 -11.172 -17.331 -33.132 1.00 80.99 O \\\\nATOM 3328 N ILE A 419 -8.483 -18.912 -33.221 1.00 81.26 N \\\\nATOM 3329 CA ILE A 419 -7.231 -19.055 -33.965 1.00 81.26 C \\\\nATOM 3330 C ILE A 419 -6.295 -19.973 -33.174 1.00 81.26 C \\\\nATOM 3331 CB ILE A 419 -6.594 -17.676 -34.263 1.00 81.26 C \\\\nATOM 3332 O ILE A 419 -5.882 -19.659 -32.058 1.00 81.26 O \\\\nATOM 3333 CG1 ILE A 419 -7.578 -16.783 -35.058 1.00 81.26 C \\\\nATOM 3334 CG2 ILE A 419 -5.278 -17.863 -35.045 1.00 81.26 C \\\\nATOM 3335 CD1 ILE A 419 -7.081 -15.352 -35.301 1.00 81.26 C \\\\nATOM 3336 N ARG A 420 -5.929 -21.114 -33.767 1.00 83.97 N \\\\nATOM 3337 CA ARG A 420 -4.920 -22.014 -33.193 1.00 83.97 C \\\\nATOM 3338 C ARG A 420 -3.526 -21.423 -33.385 1.00 83.97 C \\\\nATOM 3339 CB ARG A 420 -5.003 -23.414 -33.814 1.00 83.97 C \\\\nATOM 3340 O ARG A 420 -3.164 -21.055 -34.499 1.00 83.97 O \\\\nATOM 3341 CG ARG A 420 -6.335 -24.106 -33.502 1.00 83.97 C \\\\nATOM 3342 CD ARG A 420 -6.312 -25.543 -34.028 1.00 83.97 C \\\\nATOM 3343 NE ARG A 420 -7.597 -26.219 -33.779 1.00 83.97 N \\\\nATOM 3344 NH1 ARG A 420 -6.954 -28.339 -34.384 1.00 83.97 N \\\\nATOM 3345 NH2 ARG A 420 -9.053 -27.965 -33.716 1.00 83.97 N \\\\nATOM 3346 CZ ARG A 420 -7.860 -27.500 -33.960 1.00 83.97 C \\\\nATOM 3347 N CYS A 421 -2.733 -21.398 -32.318 1.00 83.68 N \\\\nATOM 3348 CA CYS A 421 -1.320 -21.044 -32.406 1.00 83.68 C \\\\nATOM 3349 C CYS A 421 -0.531 -22.142 -33.143 1.00 83.68 C \\\\nATOM 3350 CB CYS A 421 -0.786 -20.779 -30.993 1.00 83.68 C \\\\nATOM 3351 O CYS A 421 -0.792 -23.334 -32.955 1.00 83.68 O \\\\nATOM 3352 SG CYS A 421 0.817 -19.947 -31.129 1.00 83.68 S \\\\nATOM 3353 N SER A 422 0.433 -21.746 -33.976 1.00 85.93 N \\\\nATOM 3354 CA SER A 422 1.379 -22.670 -34.607 1.00 85.93 C \\\\nATOM 3355 C SER A 422 2.461 -23.078 -33.607 1.00 85.93 C \\\\nATOM 3356 CB SER A 422 2.006 -22.014 -35.839 1.00 85.93 C \\\\nATOM 3357 O SER A 422 2.934 -22.264 -32.823 1.00 85.93 O \\\\nATOM 3358 OG SER A 422 3.003 -22.843 -36.411 1.00 85.93 O \\\\nATOM 3359 N SER A 423 2.904 -24.335 -33.658 1.00 89.58 N \\\\nATOM 3360 CA SER A 423 4.051 -24.816 -32.874 1.00 89.58 C \\\\nATOM 3361 C SER A 423 5.402 -24.609 -33.580 1.00 89.58 C \\\\nATOM 3362 CB SER A 423 3.834 -26.286 -32.505 1.00 89.58 C \\\\nATOM 3363 O SER A 423 6.389 -25.223 -33.179 1.00 89.58 O \\\\nATOM 3364 OG SER A 423 3.847 -27.096 -33.667 1.00 89.58 O \\\\nATOM 3365 N VAL A 424 5.430 -23.853 -34.686 1.00 86.04 N \\\\nATOM 3366 CA VAL A 424 6.582 -23.732 -35.608 1.00 86.04 C \\\\nATOM 3367 C VAL A 424 6.860 -22.279 -36.040 1.00 86.04 C \\\\nATOM 3368 CB VAL A 424 6.367 -24.626 -36.861 1.00 86.04 C \\\\nATOM 3369 O VAL A 424 7.895 -22.021 -36.645 1.00 86.04 O \\\\nATOM 3370 CG1 VAL A 424 7.640 -24.833 -37.700 1.00 86.04 C \\\\nATOM 3371 CG2 VAL A 424 5.872 -26.041 -36.507 1.00 86.04 C \\\\nATOM 3372 N SER A 425 5.935 -21.348 -35.773 1.00 67.52 N \\\\nATOM 3373 CA SER A 425 6.045 -19.920 -36.132 1.00 67.52 C \\\\nATOM 3374 C SER A 425 7.004 -19.152 -35.232 1.00 67.52 C \\\\nATOM 3375 CB SER A 425 4.678 -19.249 -36.048 1.00 67.52 C \\\\nATOM 3376 O SER A 425 6.854 -19.333 -34.002 1.00 67.52 O \\\\nATOM 3377 OG SER A 425 4.186 -19.498 -34.749 1.00 67.52 O \\\\nATOM 3378 OXT SER A 425 7.754 -18.328 -35.788 1.00 67.52 O \\\\nTER 3379 SER A 425 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 9, 'score': 0}, {'residue_no': 10, 'score': 0}, {'residue_no': 11, 'score': 0}, {'residue_no': 12, 'score': 0}, {'residue_no': 13, 'score': 0}, {'residue_no': 14, 'score': 0}, {'residue_no': 15, 'score': 0}, {'residue_no': 16, 'score': 0}, {'residue_no': 17, 'score': 0}, {'residue_no': 18, 'score': 0}, {'residue_no': 19, 'score': 0}, {'residue_no': 20, 'score': 0}, {'residue_no': 21, 'score': 0}, {'residue_no': 22, 'score': 0}, {'residue_no': 23, 'score': 0}, {'residue_no': 24, 'score': 0}, {'residue_no': 25, 'score': 0}, {'residue_no': 26, 'score': 0}, {'residue_no': 27, 'score': 0}, {'residue_no': 28, 'score': 0}, {'residue_no': 29, 'score': 0}, {'residue_no': 30, 'score': 0}, {'residue_no': 31, 'score': 0}, {'residue_no': 32, 'score': 0}, {'residue_no': 33, 'score': 0}, {'residue_no': 34, 'score': 0}, {'residue_no': 35, 'score': 0}, {'residue_no': 36, 'score': 0}, {'residue_no': 37, 'score': 0}, {'residue_no': 38, 'score': 0}, {'residue_no': 39, 'score': 0}, {'residue_no': 40, 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318: 'PRO318', 319: 'ASN319', 320: 'CYS320', 321: 'ASN321', 322: 'GLN322', 323: 'ARG323', 324: 'TYR324', 325: 'GLY325', 326: 'TRP326', 327: 'HIS327', 328: 'PRO328', 329: 'ALA329', 330: 'THR330', 331: 'VAL331', 332: 'CYS332', 333: 'LYS333', 334: 'ILE334', 335: 'PRO335', 336: 'PRO336', 337: 'GLY337', 338: 'CYS338', 339: 'ASN339', 340: 'LEU340', 341: 'LYS341', 342: 'ILE342', 343: 'PHE343', 344: 'ASN344', 345: 'ASN345', 346: 'GLN346', 347: 'GLU347', 348: 'PHE348', 349: 'ALA349', 350: 'ALA350', 351: 'LEU351', 352: 'LEU352', 353: 'ALA353', 354: 'GLN354', 355: 'SER355', 356: 'VAL356', 357: 'ASN357', 358: 'GLN358', 359: 'GLY359', 360: 'PHE360', 361: 'GLU361', 362: 'ALA362', 363: 'VAL363', 364: 'TYR364', 365: 'GLN365', 366: 'LEU366', 367: 'THR367', 368: 'ARG368', 369: 'MET369', 370: 'CYS370', 371: 'THR371', 372: 'ILE372', 373: 'ARG373', 374: 'MET374', 375: 'SER375', 376: 'PHE376', 377: 'VAL377', 378: 'LYS378', 379: 'GLY379', 380: 'TRP380', 381: 'GLY381', 382: 'ALA382', 383: 'GLU383', 384: 'TYR384', 385: 'ARG385', 386: 'ARG386', 387: 'GLN387', 388: 'THR388', 389: 'VAL389', 390: 'THR390', 391: 'SER391', 392: 'THR392', 393: 'PRO393', 394: 'CYS394', 395: 'TRP395', 396: 'ILE396', 397: 'GLU397', 398: 'LEU398', 399: 'HIS399', 400: 'LEU400', 401: 'ASN401', 402: 'GLY402', 403: 'PRO403', 404: 'LEU404', 405: 'GLN405', 406: 'TRP406', 407: 'LEU407', 408: 'ASP408', 409: 'LYS409', 410: 'VAL410', 411: 'LEU411', 412: 'THR412', 413: 'GLN413', 414: 'MET414', 415: 'GLY415', 416: 'SER416', 417: 'PRO417', 418: 'SER418', 419: 'ILE419', 420: 'ARG420', 421: 'CYS421', 422: 'SER422', 423: 'SER423', 424: 'VAL424', 425: 'SER425'}}}}\\n[TOOL RUN] → MSigDB\\n[MSigDB] Predictions fetched\\n*NAME* uniprot_base\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': ['SMAD2', 'SMAD3'], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id=None, ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=[], functions=[], diseases=[], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={}, nonhuman_interactions={}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={}, avg_exons_per_transcript=None, transcript_count=None, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\"], tools_run=['EntityExtraction', 'MSigDB']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id=None, ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=[], functions=[], diseases=[], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={}, nonhuman_interactions={}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={}, avg_exons_per_transcript=None, transcript_count=None, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, 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    \\\\n
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    \\\\n\\\\n\\\\n', 'chembl_html': '\\\\n\\\\n\\\\n \\\\n ChEMBL Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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    ChEMBL ID / NameMolecule TypeFirst ApprovalIndicationsMechanism2D Structure
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    ChEMBL IDMolecule TypeEvidence2D Structure
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'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 2 (Q15796) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 467 UNP Q15796 SMAD2_HUMAN 1 467 \\\\nSEQRES 1 A 467 MET SER SER ILE LEU PRO PHE THR PRO PRO VAL VAL LYS \\\\nSEQRES 2 A 467 ARG LEU LEU GLY TRP LYS LYS SER ALA GLY GLY SER GLY \\\\nSEQRES 3 A 467 GLY ALA GLY GLY GLY GLU GLN ASN GLY GLN GLU GLU LYS \\\\nSEQRES 4 A 467 TRP CYS GLU LYS ALA VAL LYS SER LEU VAL LYS LYS LEU \\\\nSEQRES 5 A 467 LYS LYS THR GLY ARG LEU ASP GLU LEU GLU LYS ALA ILE \\\\nSEQRES 6 A 467 THR THR GLN ASN CYS ASN THR LYS CYS VAL THR ILE PRO \\\\nSEQRES 7 A 467 SER THR CYS SER GLU ILE TRP GLY LEU SER THR PRO ASN \\\\nSEQRES 8 A 467 THR ILE ASP GLN TRP ASP THR THR GLY LEU TYR SER PHE \\\\nSEQRES 9 A 467 SER GLU GLN THR ARG SER LEU ASP GLY ARG LEU GLN VAL \\\\nSEQRES 10 A 467 SER HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG \\\\nSEQRES 11 A 467 LEU TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU \\\\nSEQRES 12 A 467 LYS ALA ILE GLU ASN CYS GLU TYR ALA PHE ASN LEU LYS \\\\nSEQRES 13 A 467 LYS ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG \\\\nSEQRES 14 A 467 VAL GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG \\\\nSEQRES 15 A 467 HIS THR GLU ILE LEU THR GLU LEU PRO PRO LEU ASP ASP \\\\nSEQRES 16 A 467 TYR THR HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA \\\\nSEQRES 17 A 467 GLY ILE GLU PRO GLN SER ASN TYR ILE PRO GLU THR PRO \\\\nSEQRES 18 A 467 PRO PRO GLY TYR ILE SER GLU ASP GLY GLU THR SER ASP \\\\nSEQRES 19 A 467 GLN GLN LEU ASN GLN SER MET ASP THR GLY SER PRO ALA \\\\nSEQRES 20 A 467 GLU LEU SER PRO THR THR LEU SER PRO VAL ASN HIS SER \\\\nSEQRES 21 A 467 LEU ASP LEU GLN PRO VAL THR TYR SER GLU PRO ALA PHE \\\\nSEQRES 22 A 467 TRP CYS SER ILE ALA TYR TYR GLU LEU ASN GLN ARG VAL \\\\nSEQRES 23 A 467 GLY GLU THR PHE HIS ALA SER GLN PRO SER LEU THR VAL \\\\nSEQRES 24 A 467 ASP GLY PHE THR ASP PRO SER ASN SER GLU ARG PHE CYS \\\\nSEQRES 25 A 467 LEU GLY LEU LEU SER ASN VAL ASN ARG ASN ALA THR VAL \\\\nSEQRES 26 A 467 GLU MET THR ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU \\\\nSEQRES 27 A 467 TYR TYR ILE GLY GLY GLU VAL PHE ALA GLU CYS LEU SER \\\\nSEQRES 28 A 467 ASP SER ALA ILE PHE VAL GLN SER PRO ASN CYS ASN GLN \\\\nSEQRES 29 A 467 ARG TYR GLY TRP HIS PRO ALA THR VAL CYS LYS ILE PRO \\\\nSEQRES 30 A 467 PRO GLY CYS ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE \\\\nSEQRES 31 A 467 ALA ALA LEU LEU ALA GLN SER VAL ASN GLN GLY PHE GLU \\\\nSEQRES 32 A 467 ALA VAL TYR GLN LEU THR ARG MET CYS THR ILE ARG MET \\\\nSEQRES 33 A 467 SER PHE VAL LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN \\\\nSEQRES 34 A 467 THR VAL THR SER THR PRO CYS TRP ILE GLU LEU HIS LEU \\\\nSEQRES 35 A 467 ASN GLY PRO LEU GLN TRP LEU ASP LYS VAL LEU THR GLN \\\\nSEQRES 36 A 467 MET GLY SER PRO SER VAL ARG CYS SER SER MET SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 -24.572 -42.101 26.586 1.00 40.65 N \\\\nATOM 2 CA MET A 1 -23.660 -40.986 26.918 1.00 40.65 C \\\\nATOM 3 C MET A 1 -24.312 -39.697 26.444 1.00 40.65 C \\\\nATOM 4 CB MET A 1 -22.280 -41.179 26.264 1.00 40.65 C \\\\nATOM 5 O MET A 1 -24.227 -39.375 25.268 1.00 40.65 O \\\\nATOM 6 CG MET A 1 -21.477 -42.313 26.910 1.00 40.65 C \\\\nATOM 7 SD MET A 1 -19.880 -42.579 26.105 1.00 40.65 S \\\\nATOM 8 CE MET A 1 -19.199 -43.908 27.135 1.00 40.65 C \\\\nATOM 9 N SER A 2 -25.061 -39.026 27.318 1.00 40.07 N \\\\nATOM 10 CA SER A 2 -25.762 -37.787 26.974 1.00 40.07 C \\\\nATOM 11 C SER A 2 -24.744 -36.657 26.853 1.00 40.07 C \\\\nATOM 12 CB SER A 2 -26.833 -37.463 28.023 1.00 40.07 C \\\\nATOM 13 O SER A 2 -24.164 -36.225 27.847 1.00 40.07 O \\\\nATOM 14 OG SER A 2 -27.659 -38.600 28.207 1.00 40.07 O \\\\nATOM 15 N SER A 3 -24.488 -36.213 25.627 1.00 41.96 N \\\\nATOM 16 CA SER A 3 -23.669 -35.042 25.327 1.00 41.96 C \\\\nATOM 17 C SER A 3 -24.297 -33.802 25.968 1.00 41.96 C \\\\nATOM 18 CB SER A 3 -23.571 -34.885 23.804 1.00 41.96 C \\\\nATOM 19 O SER A 3 -25.347 -33.334 25.529 1.00 41.96 O \\\\nATOM 20 OG SER A 3 -24.856 -34.989 23.221 1.00 41.96 O \\\\nATOM 21 N ILE A 4 -23.663 -33.281 27.020 1.00 49.09 N \\\\nATOM 22 CA ILE A 4 -24.019 -32.004 27.645 1.00 49.09 C \\\\nATOM 23 C ILE A 4 -23.817 -30.914 26.587 1.00 49.09 C \\\\nATOM 24 CB ILE A 4 -23.162 -31.774 28.918 1.00 49.09 C \\\\nATOM 25 O ILE A 4 -22.683 -30.590 26.230 1.00 49.09 O \\\\nATOM 26 CG1 ILE A 4 -23.467 -32.865 29.975 1.00 49.09 C \\\\nATOM 27 CG2 ILE A 4 -23.401 -30.371 29.509 1.00 49.09 C \\\\nATOM 28 CD1 ILE A 4 -22.507 -32.870 31.172 1.00 49.09 C \\\\nATOM 29 N LEU A 5 -24.914 -30.374 26.051 1.00 54.35 N \\\\nATOM 30 CA LEU A 5 -24.866 -29.217 25.160 1.00 54.35 C \\\\nATOM 31 C LEU A 5 -24.174 -28.057 25.901 1.00 54.35 C \\\\nATOM 32 CB LEU A 5 -26.287 -28.820 24.715 1.00 54.35 C \\\\nATOM 33 O LEU A 5 -24.526 -27.781 27.052 1.00 54.35 O \\\\nATOM 34 CG LEU A 5 -26.968 -29.818 23.758 1.00 54.35 C \\\\nATOM 35 CD1 LEU A 5 -28.438 -29.436 23.583 1.00 54.35 C \\\\nATOM 36 CD2 LEU A 5 -26.309 -29.824 22.376 1.00 54.35 C \\\\nATOM 37 N PRO A 6 -23.190 -27.372 25.292 1.00 60.96 N \\\\nATOM 38 CA PRO A 6 -22.455 -26.309 25.964 1.00 60.96 C \\\\nATOM 39 C PRO A 6 -23.410 -25.182 26.380 1.00 60.96 C \\\\nATOM 40 CB PRO A 6 -21.373 -25.863 24.972 1.00 60.96 C \\\\nATOM 41 O PRO A 6 -24.093 -24.583 25.551 1.00 60.96 O \\\\nATOM 42 CG PRO A 6 -21.914 -26.299 23.609 1.00 60.96 C \\\\nATOM 43 CD PRO A 6 -22.720 -27.553 23.930 1.00 60.96 C \\\\nATOM 44 N PHE A 7 -23.456 -24.883 27.680 1.00 70.11 N \\\\nATOM 45 CA PHE A 7 -24.301 -23.825 28.228 1.00 70.11 C \\\\nATOM 46 C PHE A 7 -23.821 -22.449 27.741 1.00 70.11 C \\\\nATOM 47 CB PHE A 7 -24.316 -23.929 29.761 1.00 70.11 C \\\\nATOM 48 O PHE A 7 -22.785 -21.940 28.176 1.00 70.11 O \\\\nATOM 49 CG PHE A 7 -25.218 -22.917 30.448 1.00 70.11 C \\\\nATOM 50 CD1 PHE A 7 -24.682 -21.724 30.971 1.00 70.11 C \\\\nATOM 51 CD2 PHE A 7 -26.594 -23.180 30.586 1.00 70.11 C \\\\nATOM 52 CE1 PHE A 7 -25.515 -20.804 31.634 1.00 70.11 C \\\\nATOM 53 CE2 PHE A 7 -27.427 -22.259 31.246 1.00 70.11 C \\\\nATOM 54 CZ PHE A 7 -26.888 -21.073 31.773 1.00 70.11 C \\\\nATOM 55 N THR A 8 -24.572 -21.829 26.831 1.00 74.66 N \\\\nATOM 56 CA THR A 8 -24.329 -20.445 26.401 1.00 74.66 C \\\\nATOM 57 C THR A 8 -25.030 -19.480 27.363 1.00 74.66 C \\\\nATOM 58 CB THR A 8 -24.728 -20.221 24.936 1.00 74.66 C \\\\nATOM 59 O THR A 8 -26.260 -19.534 27.459 1.00 74.66 O \\\\nATOM 60 CG2 THR A 8 -24.478 -18.787 24.475 1.00 74.66 C \\\\nATOM 61 OG1 THR A 8 -23.883 -21.048 24.178 1.00 74.66 O \\\\nATOM 62 N PRO A 9 -24.291 -18.587 28.061 1.00 81.38 N \\\\nATOM 63 CA PRO A 9 -24.875 -17.665 29.034 1.00 81.38 C \\\\nATOM 64 C PRO A 9 -26.022 -16.833 28.430 1.00 81.38 C \\\\nATOM 65 CB PRO A 9 -23.725 -16.765 29.501 1.00 81.38 C \\\\nATOM 66 O PRO A 9 -25.880 -16.379 27.291 1.00 81.38 O \\\\nATOM 67 CG PRO A 9 -22.486 -17.630 29.288 1.00 81.38 C \\\\nATOM 68 CD PRO A 9 -22.839 -18.444 28.047 1.00 81.38 C \\\\nATOM 69 N PRO A 10 -27.113 -16.546 29.170 1.00 88.04 N \\\\nATOM 70 CA PRO A 10 -28.265 -15.803 28.643 1.00 88.04 C \\\\nATOM 71 C PRO A 10 -27.903 -14.455 28.006 1.00 88.04 C \\\\nATOM 72 CB PRO A 10 -29.206 -15.617 29.838 1.00 88.04 C \\\\nATOM 73 O PRO A 10 -28.428 -14.103 26.954 1.00 88.04 O \\\\nATOM 74 CG PRO A 10 -28.904 -16.831 30.714 1.00 88.04 C \\\\nATOM 75 CD PRO A 10 -27.408 -17.050 30.507 1.00 88.04 C \\\\nATOM 76 N VAL A 11 -26.942 -13.728 28.587 1.00 89.17 N \\\\nATOM 77 CA VAL A 11 -26.420 -12.472 28.018 1.00 89.17 C \\\\nATOM 78 C VAL A 11 -25.778 -12.654 26.641 1.00 89.17 C \\\\nATOM 79 CB VAL A 11 -25.444 -11.785 28.991 1.00 89.17 C \\\\nATOM 80 O VAL A 11 -25.989 -11.835 25.755 1.00 89.17 O \\\\nATOM 81 CG1 VAL A 11 -24.266 -12.670 29.436 1.00 89.17 C \\\\nATOM 82 CG2 VAL A 11 -24.874 -10.512 28.374 1.00 89.17 C \\\\nATOM 83 N VAL A 12 -25.047 -13.750 26.421 1.00 90.18 N \\\\nATOM 84 CA VAL A 12 -24.426 -14.037 25.121 1.00 90.18 C \\\\nATOM 85 C VAL A 12 -25.511 -14.301 24.081 1.00 90.18 C \\\\nATOM 86 CB VAL A 12 -23.450 -15.222 25.221 1.00 90.18 C \\\\nATOM 87 O VAL A 12 -25.415 -13.779 22.976 1.00 90.18 O \\\\nATOM 88 CG1 VAL A 12 -22.897 -15.653 23.860 1.00 90.18 C \\\\nATOM 89 CG2 VAL A 12 -22.261 -14.884 26.131 1.00 90.18 C \\\\nATOM 90 N LYS A 13 -26.567 -15.046 24.443 1.00 90.09 N \\\\nATOM 91 CA LYS A 13 -27.716 -15.269 23.551 1.00 90.09 C \\\\nATOM 92 C LYS A 13 -28.409 -13.955 23.179 1.00 90.09 C \\\\nATOM 93 CB LYS A 13 -28.730 -16.246 24.165 1.00 90.09 C \\\\nATOM 94 O LYS A 13 -28.685 -13.747 22.005 1.00 90.09 O \\\\nATOM 95 CG LYS A 13 -28.180 -17.668 24.349 1.00 90.09 C \\\\nATOM 96 CD LYS A 13 -29.318 -18.629 24.722 1.00 90.09 C \\\\nATOM 97 CE LYS A 13 -28.790 -20.054 24.924 1.00 90.09 C \\\\nATOM 98 NZ LYS A 13 -29.892 -21.005 25.223 1.00 90.09 N \\\\nATOM 99 N ARG A 14 -28.629 -13.054 24.148 1.00 91.11 N \\\\nATOM 100 CA ARG A 14 -29.205 -11.720 23.892 1.00 91.11 C \\\\nATOM 101 C ARG A 14 -28.332 -10.898 22.938 1.00 91.11 C \\\\nATOM 102 CB ARG A 14 -29.461 -10.958 25.206 1.00 91.11 C \\\\nATOM 103 O ARG A 14 -28.825 -10.440 21.917 1.00 91.11 O \\\\nATOM 104 CG ARG A 14 -30.632 -11.542 26.016 1.00 91.11 C \\\\nATOM 105 CD ARG A 14 -31.021 -10.655 27.210 1.00 91.11 C \\\\nATOM 106 NE ARG A 14 -29.967 -10.579 28.245 1.00 91.11 N \\\\nATOM 107 NH1 ARG A 14 -30.351 -8.417 28.976 1.00 91.11 N \\\\nATOM 108 NH2 ARG A 14 -28.636 -9.524 29.765 1.00 91.11 N \\\\nATOM 109 CZ ARG A 14 -29.674 -9.525 28.994 1.00 91.11 C \\\\nATOM 110 N LEU A 15 -27.028 -10.803 23.213 1.00 92.52 N \\\\nATOM 111 CA LEU A 15 -26.075 -10.061 22.377 1.00 92.52 C \\\\nATOM 112 C LEU A 15 -25.955 -10.606 20.948 1.00 92.52 C \\\\nATOM 113 CB LEU A 15 -24.703 -10.023 23.065 1.00 92.52 C \\\\nATOM 114 O LEU A 15 -25.822 -9.822 20.009 1.00 92.52 O \\\\nATOM 115 CG LEU A 15 -24.615 -9.069 24.270 1.00 92.52 C \\\\nATOM 116 CD1 LEU A 15 -23.259 -9.267 24.947 1.00 92.52 C \\\\nATOM 117 CD2 LEU A 15 -24.711 -7.596 23.880 1.00 92.52 C \\\\nATOM 118 N LEU A 16 -26.018 -11.929 20.780 1.00 91.58 N \\\\nATOM 119 CA LEU A 16 -26.069 -12.567 19.463 1.00 91.58 C \\\\nATOM 120 C LEU A 16 -27.408 -12.329 18.751 1.00 91.58 C \\\\nATOM 121 CB LEU A 16 -25.795 -14.073 19.608 1.00 91.58 C \\\\nATOM 122 O LEU A 16 -27.421 -12.254 17.529 1.00 91.58 O \\\\nATOM 123 CG LEU A 16 -24.336 -14.414 19.952 1.00 91.58 C \\\\nATOM 124 CD1 LEU A 16 -24.237 -15.887 20.345 1.00 91.58 C \\\\nATOM 125 CD2 LEU A 16 -23.386 -14.167 18.776 1.00 91.58 C \\\\nATOM 126 N GLY A 17 -28.506 -12.153 19.491 1.00 90.58 N \\\\nATOM 127 CA GLY A 17 -29.823 -11.820 18.939 1.00 90.58 C \\\\nATOM 128 C GLY A 17 -29.896 -10.443 18.269 1.00 90.58 C \\\\nATOM 129 O GLY A 17 -30.723 -10.244 17.387 1.00 90.58 O \\\\nATOM 130 N TRP A 18 -29.005 -9.510 18.625 1.00 91.39 N \\\\nATOM 131 CA TRP A 18 -28.865 -8.217 17.938 1.00 91.39 C \\\\nATOM 132 C TRP A 18 -27.843 -8.234 16.792 1.00 91.39 C \\\\nATOM 133 CB TRP A 18 -28.548 -7.112 18.953 1.00 91.39 C \\\\nATOM 134 O TRP A 18 -27.576 -7.184 16.202 1.00 91.39 O \\\\nATOM 135 CG TRP A 18 -29.603 -6.871 19.988 1.00 91.39 C \\\\nATOM 136 CD1 TRP A 18 -30.872 -6.473 19.747 1.00 91.39 C \\\\nATOM 137 CD2 TRP A 18 -29.499 -6.995 21.436 1.00 91.39 C \\\\nATOM 138 CE2 TRP A 18 -30.766 -6.701 22.015 1.00 91.39 C \\\\nATOM 139 CE3 TRP A 18 -28.444 -7.289 22.320 1.00 91.39 C \\\\nATOM 140 NE1 TRP A 18 -31.560 -6.364 20.941 1.00 91.39 N \\\\nATOM 141 CH2 TRP A 18 -29.924 -7.101 24.250 1.00 91.39 C \\\\nATOM 142 CZ2 TRP A 18 -30.987 -6.753 23.399 1.00 91.39 C \\\\nATOM 143 CZ3 TRP A 18 -28.652 -7.369 23.711 1.00 91.39 C \\\\nATOM 144 N LYS A 19 -27.241 -9.392 16.475 1.00 91.72 N \\\\nATOM 145 CA LYS A 19 -26.306 -9.514 15.351 1.00 91.72 C \\\\nATOM 146 C LYS A 19 -27.019 -9.139 14.049 1.00 91.72 C \\\\nATOM 147 CB LYS A 19 -25.718 -10.938 15.266 1.00 91.72 C \\\\nATOM 148 O LYS A 19 -28.107 -9.635 13.766 1.00 91.72 O \\\\nATOM 149 CG LYS A 19 -24.561 -11.002 14.256 1.00 91.72 C \\\\nATOM 150 CD LYS A 19 -23.988 -12.398 13.957 1.00 91.72 C \\\\nATOM 151 CE LYS A 19 -24.732 -13.086 12.796 1.00 91.72 C \\\\nATOM 152 NZ LYS A 19 -23.912 -14.127 12.109 1.00 91.72 N \\\\nATOM 153 N LYS A 20 -26.391 -8.297 13.232 1.00 89.42 N \\\\nATOM 154 CA LYS A 20 -26.866 -8.016 11.872 1.00 89.42 C \\\\nATOM 155 C LYS A 20 -26.457 -9.165 10.944 1.00 89.42 C \\\\nATOM 156 CB LYS A 20 -26.344 -6.646 11.412 1.00 89.42 C \\\\nATOM 157 O LYS A 20 -25.346 -9.681 11.042 1.00 89.42 O \\\\nATOM 158 CG LYS A 20 -26.864 -5.469 12.253 1.00 89.42 C \\\\nATOM 159 CD LYS A 20 -28.377 -5.244 12.136 1.00 89.42 C \\\\nATOM 160 CE LYS A 20 -28.752 -3.968 12.896 1.00 89.42 C \\\\nATOM 161 NZ LYS A 20 -30.202 -3.672 12.787 1.00 89.42 N \\\\nATOM 162 N SER A 21 -27.358 -9.582 10.060 1.00 76.73 N \\\\nATOM 163 CA SER A 21 -27.071 -10.613 9.052 1.00 76.73 C \\\\nATOM 164 C SER A 21 -26.585 -9.953 7.766 1.00 76.73 C \\\\nATOM 165 CB SER A 21 -28.301 -11.487 8.791 1.00 76.73 C \\\\nATOM 166 O SER A 21 -27.132 -8.922 7.375 1.00 76.73 O \\\\nATOM 167 OG SER A 21 -28.651 -12.154 9.990 1.00 76.73 O \\\\nATOM 168 N ALA A 22 -25.577 -10.531 7.110 1.00 64.94 N \\\\nATOM 169 CA ALA A 22 -25.187 -10.124 5.764 1.00 64.94 C \\\\nATOM 170 C ALA A 22 -26.336 -10.489 4.805 1.00 64.94 C \\\\nATOM 171 CB ALA A 22 -23.856 -10.800 5.410 1.00 64.94 C \\\\nATOM 172 O ALA A 22 -26.600 -11.663 4.556 1.00 64.94 O \\\\nATOM 173 N GLY A 23 -27.108 -9.492 4.371 1.00 48.74 N \\\\nATOM 174 CA GLY A 23 -28.290 -9.689 3.538 1.00 48.74 C \\\\nATOM 175 C GLY A 23 -27.919 -10.007 2.093 1.00 48.74 C \\\\nATOM 176 O GLY A 23 -27.514 -9.117 1.356 1.00 48.74 O \\\\nATOM 177 N GLY A 24 -28.113 -11.264 1.698 1.00 39.25 N \\\\nATOM 178 CA GLY A 24 -28.194 -11.733 0.318 1.00 39.25 C \\\\nATOM 179 C GLY A 24 -29.205 -12.877 0.266 1.00 39.25 C \\\\nATOM 180 O GLY A 24 -29.023 -13.914 0.899 1.00 39.25 O \\\\nATOM 181 N SER A 25 -30.318 -12.649 -0.416 1.00 33.12 N \\\\nATOM 182 CA SER A 25 -31.419 -13.586 -0.628 1.00 33.12 C \\\\nATOM 183 C SER A 25 -30.967 -14.913 -1.254 1.00 33.12 C \\\\nATOM 184 CB SER A 25 -32.416 -12.900 -1.572 1.00 33.12 C \\\\nATOM 185 O SER A 25 -30.346 -14.912 -2.309 1.00 33.12 O \\\\nATOM 186 OG SER A 25 -31.719 -12.289 -2.643 1.00 33.12 O \\\\nATOM 187 N GLY A 26 -31.363 -16.033 -0.638 1.00 28.12 N \\\\nATOM 188 CA GLY A 26 -31.713 -17.288 -1.318 1.00 28.12 C \\\\nATOM 189 C GLY A 26 -30.714 -17.865 -2.327 1.00 28.12 C \\\\nATOM 190 O GLY A 26 -31.011 -17.915 -3.514 1.00 28.12 O \\\\nATOM 191 N GLY A 27 -29.588 -18.400 -1.852 1.00 31.96 N \\\\nATOM 192 CA GLY A 27 -28.741 -19.320 -2.619 1.00 31.96 C \\\\nATOM 193 C GLY A 27 -28.473 -20.587 -1.809 1.00 31.96 C \\\\nATOM 194 O GLY A 27 -27.802 -20.534 -0.781 1.00 31.96 O \\\\nATOM 195 N ALA A 28 -29.004 -21.729 -2.247 1.00 35.83 N \\\\nATOM 196 CA ALA A 28 -29.006 -23.014 -1.534 1.00 35.83 C \\\\nATOM 197 C ALA A 28 -27.627 -23.724 -1.429 1.00 35.83 C \\\\nATOM 198 CB ALA A 28 -30.091 -23.891 -2.180 1.00 35.83 C \\\\nATOM 199 O ALA A 28 -27.569 -24.948 -1.371 1.00 35.83 O \\\\nATOM 200 N GLY A 29 -26.513 -22.981 -1.385 1.00 39.37 N \\\\nATOM 201 CA GLY A 29 -25.144 -23.526 -1.411 1.00 39.37 C \\\\nATOM 202 C GLY A 29 -24.241 -23.187 -0.213 1.00 39.37 C \\\\nATOM 203 O GLY A 29 -23.067 -23.534 -0.238 1.00 39.37 O \\\\nATOM 204 N GLY A 30 -24.737 -22.500 0.828 1.00 39.93 N \\\\nATOM 205 CA GLY A 30 -23.887 -21.862 1.859 1.00 39.93 C \\\\nATOM 206 C GLY A 30 -23.858 -22.484 3.267 1.00 39.93 C \\\\nATOM 207 O GLY A 30 -23.334 -21.854 4.188 1.00 39.93 O \\\\nATOM 208 N GLY A 31 -24.432 -23.674 3.480 1.00 42.15 N \\\\nATOM 209 CA GLY A 31 -24.710 -24.205 4.828 1.00 42.15 C \\\\nATOM 210 C GLY A 31 -23.492 -24.328 5.759 1.00 42.15 C \\\\nATOM 211 O GLY A 31 -23.576 -23.985 6.939 1.00 42.15 O \\\\nATOM 212 N GLU A 32 -22.342 -24.764 5.242 1.00 51.18 N \\\\nATOM 213 CA GLU A 32 -21.145 -24.982 6.069 1.00 51.18 C \\\\nATOM 214 C GLU A 32 -20.403 -23.684 6.416 1.00 51.18 C \\\\nATOM 215 CB GLU A 32 -20.194 -25.962 5.376 1.00 51.18 C \\\\nATOM 216 O GLU A 32 -19.970 -23.505 7.559 1.00 51.18 O \\\\nATOM 217 CG GLU A 32 -20.775 -27.382 5.322 1.00 51.18 C \\\\nATOM 218 CD GLU A 32 -19.740 -28.389 4.808 1.00 51.18 C \\\\nATOM 219 OE1 GLU A 32 -19.671 -29.487 5.403 1.00 51.18 O \\\\nATOM 220 OE2 GLU A 32 -19.012 -28.029 3.858 1.00 51.18 O \\\\nATOM 221 N GLN A 33 -20.293 -22.752 5.461 1.00 56.72 N \\\\nATOM 222 CA GLN A 33 -19.598 -21.478 5.677 1.00 56.72 C \\\\nATOM 223 C GLN A 33 -20.337 -20.610 6.701 1.00 56.72 C \\\\nATOM 224 CB GLN A 33 -19.417 -20.721 4.353 1.00 56.72 C \\\\nATOM 225 O GLN A 33 -19.711 -20.066 7.616 1.00 56.72 O \\\\nATOM 226 CG GLN A 33 -18.447 -21.436 3.398 1.00 56.72 C \\\\nATOM 227 CD GLN A 33 -18.143 -20.615 2.147 1.00 56.72 C \\\\nATOM 228 NE2 GLN A 33 -17.830 -21.246 1.038 1.00 56.72 N \\\\nATOM 229 OE1 GLN A 33 -18.163 -19.397 2.144 1.00 56.72 O \\\\nATOM 230 N ASN A 34 -21.671 -20.572 6.618 1.00 67.29 N \\\\nATOM 231 CA ASN A 34 -22.498 -19.839 7.573 1.00 67.29 C \\\\nATOM 232 C ASN A 34 -22.352 -20.414 8.999 1.00 67.29 C \\\\nATOM 233 CB ASN A 34 -23.947 -19.854 7.053 1.00 67.29 C \\\\nATOM 234 O ASN A 34 -22.158 -19.676 9.965 1.00 67.29 O \\\\nATOM 235 CG ASN A 34 -24.826 -18.811 7.724 1.00 67.29 C \\\\nATOM 236 ND2 ASN A 34 -26.122 -18.906 7.550 1.00 67.29 N \\\\nATOM 237 OD1 ASN A 34 -24.377 -17.899 8.394 1.00 67.29 O \\\\nATOM 238 N GLY A 35 -22.302 -21.746 9.141 1.00 76.97 N \\\\nATOM 239 CA GLY A 35 -22.104 -22.400 10.439 1.00 76.97 C \\\\nATOM 240 C GLY A 35 -20.735 -22.124 11.081 1.00 76.97 C \\\\nATOM 241 O GLY A 35 -20.624 -22.025 12.309 1.00 76.97 O \\\\nATOM 242 N GLN A 36 -19.672 -21.979 10.284 1.00 80.76 N \\\\nATOM 243 CA GLN A 36 -18.354 -21.600 10.805 1.00 80.76 C \\\\nATOM 244 C GLN A 36 -18.326 -20.136 11.266 1.00 80.76 C \\\\nATOM 245 CB GLN A 36 -17.275 -21.880 9.750 1.00 80.76 C \\\\nATOM 246 O GLN A 36 -17.717 -19.827 12.298 1.00 80.76 O \\\\nATOM 247 CG GLN A 36 -15.860 -21.709 10.331 1.00 80.76 C \\\\nATOM 248 CD GLN A 36 -14.756 -22.070 9.342 1.00 80.76 C \\\\nATOM 249 NE2 GLN A 36 -13.504 -22.038 9.743 1.00 80.76 N \\\\nATOM 250 OE1 GLN A 36 -14.971 -22.380 8.191 1.00 80.76 O \\\\nATOM 251 N GLU A 37 -18.996 -19.248 10.534 1.00 83.37 N \\\\nATOM 252 CA GLU A 37 -19.110 -17.836 10.887 1.00 83.37 C \\\\nATOM 253 C GLU A 37 -19.920 -17.630 12.171 1.00 83.37 C \\\\nATOM 254 CB GLU A 37 -19.705 -17.064 9.706 1.00 83.37 C \\\\nATOM 255 O GLU A 37 -19.465 -16.931 13.078 1.00 83.37 O \\\\nATOM 256 CG GLU A 37 -19.659 -15.560 9.998 1.00 83.37 C \\\\nATOM 257 CD GLU A 37 -20.107 -14.688 8.825 1.00 83.37 C \\\\nATOM 258 OE1 GLU A 37 -20.015 -13.455 9.018 1.00 83.37 O \\\\nATOM 259 OE2 GLU A 37 -20.523 -15.243 7.790 1.00 83.37 O \\\\nATOM 260 N GLU A 38 -21.059 -18.306 12.322 1.00 85.66 N \\\\nATOM 261 CA GLU A 38 -21.865 -18.251 13.546 1.00 85.66 C \\\\nATOM 262 C GLU A 38 -21.082 -18.708 14.781 1.00 85.66 C \\\\nATOM 263 CB GLU A 38 -23.114 -19.119 13.390 1.00 85.66 C \\\\nATOM 264 O GLU A 38 -21.068 -18.015 15.806 1.00 85.66 O \\\\nATOM 265 CG GLU A 38 -24.157 -18.467 12.474 1.00 85.66 C \\\\nATOM 266 CD GLU A 38 -25.460 -19.276 12.420 1.00 85.66 C \\\\nATOM 267 OE1 GLU A 38 -26.457 -18.690 11.946 1.00 85.66 O \\\\nATOM 268 OE2 GLU A 38 -25.466 -20.426 12.919 1.00 85.66 O \\\\nATOM 269 N LYS A 39 -20.345 -19.823 14.671 1.00 86.55 N \\\\nATOM 270 CA LYS A 39 -19.451 -20.302 15.740 1.00 86.55 C \\\\nATOM 271 C LYS A 39 -18.372 -19.274 16.081 1.00 86.55 C \\\\nATOM 272 CB LYS A 39 -18.795 -21.626 15.317 1.00 86.55 C \\\\nATOM 273 O LYS A 39 -17.981 -19.150 17.245 1.00 86.55 O \\\\nATOM 274 CG LYS A 39 -19.767 -22.812 15.382 1.00 86.55 C \\\\nATOM 275 CD LYS A 39 -19.109 -24.081 14.822 1.00 86.55 C \\\\nATOM 276 CE LYS A 39 -20.135 -25.219 14.776 1.00 86.55 C \\\\nATOM 277 NZ LYS A 39 -19.592 -26.445 14.136 1.00 86.55 N \\\\nATOM 278 N TRP A 40 -17.863 -18.545 15.089 1.00 88.25 N \\\\nATOM 279 CA TRP A 40 -16.889 -17.482 15.316 1.00 88.25 C \\\\nATOM 280 C TRP A 40 -17.515 -16.281 16.041 1.00 88.25 C \\\\nATOM 281 CB TRP A 40 -16.221 -17.086 13.997 1.00 88.25 C \\\\nATOM 282 O TRP A 40 -16.951 -15.825 17.040 1.00 88.25 O \\\\nATOM 283 CG TRP A 40 -15.165 -16.048 14.177 1.00 88.25 C \\\\nATOM 284 CD1 TRP A 40 -13.860 -16.285 14.429 1.00 88.25 C \\\\nATOM 285 CD2 TRP A 40 -15.322 -14.598 14.178 1.00 88.25 C \\\\nATOM 286 CE2 TRP A 40 -14.050 -14.013 14.456 1.00 88.25 C \\\\nATOM 287 CE3 TRP A 40 -16.408 -13.723 13.961 1.00 88.25 C \\\\nATOM 288 NE1 TRP A 40 -13.204 -15.089 14.630 1.00 88.25 N \\\\nATOM 289 CH2 TRP A 40 -14.955 -11.783 14.248 1.00 88.25 C \\\\nATOM 290 CZ2 TRP A 40 -13.857 -12.626 14.495 1.00 88.25 C \\\\nATOM 291 CZ3 TRP A 40 -16.226 -12.329 13.998 1.00 88.25 C \\\\nATOM 292 N CYS A 41 -18.700 -15.828 15.616 1.00 90.26 N \\\\nATOM 293 CA CYS A 41 -19.451 -14.756 16.275 1.00 90.26 C \\\\nATOM 294 C CYS A 41 -19.745 -15.096 17.741 1.00 90.26 C \\\\nATOM 295 CB CYS A 41 -20.771 -14.510 15.529 1.00 90.26 C \\\\nATOM 296 O CYS A 41 -19.511 -14.274 18.629 1.00 90.26 O \\\\nATOM 297 SG CYS A 41 -20.480 -13.830 13.874 1.00 90.26 S \\\\nATOM 298 N GLU A 42 -20.186 -16.325 18.023 1.00 90.51 N \\\\nATOM 299 CA GLU A 42 -20.450 -16.772 19.390 1.00 90.51 C \\\\nATOM 300 C GLU A 42 -19.185 -16.721 20.259 1.00 90.51 C \\\\nATOM 301 CB GLU A 42 -21.072 -18.176 19.365 1.00 90.51 C \\\\nATOM 302 O GLU A 42 -19.226 -16.228 21.390 1.00 90.51 O \\\\nATOM 303 CG GLU A 42 -21.423 -18.629 20.789 1.00 90.51 C \\\\nATOM 304 CD GLU A 42 -22.094 -19.999 20.874 1.00 90.51 C \\\\nATOM 305 OE1 GLU A 42 -22.668 -20.264 21.960 1.00 90.51 O \\\\nATOM 306 OE2 GLU A 42 -21.847 -20.845 20.000 1.00 90.51 O \\\\nATOM 307 N LYS A 43 -18.035 -17.168 19.737 1.00 89.89 N \\\\nATOM 308 CA LYS A 43 -16.750 -17.069 20.449 1.00 89.89 C \\\\nATOM 309 C LYS A 43 -16.331 -15.615 20.685 1.00 89.89 C \\\\nATOM 310 CB LYS A 43 -15.656 -17.823 19.682 1.00 89.89 C \\\\nATOM 311 O LYS A 43 -15.843 -15.308 21.776 1.00 89.89 O \\\\nATOM 312 CG LYS A 43 -15.801 -19.351 19.770 1.00 89.89 C \\\\nATOM 313 CD LYS A 43 -14.681 -20.010 18.954 1.00 89.89 C \\\\nATOM 314 CE LYS A 43 -14.843 -21.529 18.842 1.00 89.89 C \\\\nATOM 315 NZ LYS A 43 -13.695 -22.134 18.114 1.00 89.89 N \\\\nATOM 316 N ALA A 44 -16.529 -14.728 19.707 1.00 90.90 N \\\\nATOM 317 CA ALA A 44 -16.215 -13.304 19.832 1.00 90.90 C \\\\nATOM 318 C ALA A 44 -17.040 -12.649 20.951 1.00 90.90 C \\\\nATOM 319 CB ALA A 44 -16.439 -12.611 18.479 1.00 90.90 C \\\\nATOM 320 O ALA A 44 -16.475 -12.035 21.857 1.00 90.90 O \\\\nATOM 321 N VAL A 45 -18.359 -12.866 20.957 1.00 93.13 N \\\\nATOM 322 CA VAL A 45 -19.264 -12.328 21.985 1.00 93.13 C \\\\nATOM 323 C VAL A 45 -18.977 -12.940 23.359 1.00 93.13 C \\\\nATOM 324 CB VAL A 45 -20.738 -12.517 21.575 1.00 93.13 C \\\\nATOM 325 O VAL A 45 -18.897 -12.206 24.342 1.00 93.13 O \\\\nATOM 326 CG1 VAL A 45 -21.709 -12.028 22.656 1.00 93.13 C \\\\nATOM 327 CG2 VAL A 45 -21.050 -11.716 20.305 1.00 93.13 C \\\\nATOM 328 N LYS A 46 -18.734 -14.257 23.460 1.00 90.75 N \\\\nATOM 329 CA LYS A 46 -18.327 -14.904 24.727 1.00 90.75 C \\\\nATOM 330 C LYS A 46 -17.047 -14.284 25.295 1.00 90.75 C \\\\nATOM 331 CB LYS A 46 -18.140 -16.425 24.535 1.00 90.75 C \\\\nATOM 332 O LYS A 46 -16.974 -14.020 26.497 1.00 90.75 O \\\\nATOM 333 CG LYS A 46 -19.477 -17.178 24.493 1.00 90.75 C \\\\nATOM 334 CD LYS A 46 -19.334 -18.690 24.241 1.00 90.75 C \\\\nATOM 335 CE LYS A 46 -20.738 -19.316 24.203 1.00 90.75 C \\\\nATOM 336 NZ LYS A 46 -20.772 -20.741 23.784 1.00 90.75 N \\\\nATOM 337 N SER A 47 -16.056 -14.031 24.437 1.00 89.31 N \\\\nATOM 338 CA SER A 47 -14.799 -13.380 24.817 1.00 89.31 C \\\\nATOM 339 C SER A 47 -15.031 -11.948 25.303 1.00 89.31 C \\\\nATOM 340 CB SER A 47 -13.825 -13.406 23.636 1.00 89.31 C \\\\nATOM 341 O SER A 47 -14.521 -11.576 26.363 1.00 89.31 O \\\\nATOM 342 OG SER A 47 -12.541 -12.957 24.032 1.00 89.31 O \\\\nATOM 343 N LEU A 48 -15.863 -11.169 24.599 1.00 92.11 N \\\\nATOM 344 CA LEU A 48 -16.211 -9.811 25.014 1.00 92.11 C \\\\nATOM 345 C LEU A 48 -16.908 -9.789 26.372 1.00 92.11 C \\\\nATOM 346 CB LEU A 48 -17.112 -9.131 23.972 1.00 92.11 C \\\\nATOM 347 O LEU A 48 -16.472 -9.073 27.267 1.00 92.11 O \\\\nATOM 348 CG LEU A 48 -17.369 -7.649 24.313 1.00 92.11 C \\\\nATOM 349 CD1 LEU A 48 -16.103 -6.796 24.387 1.00 92.11 C \\\\nATOM 350 CD2 LEU A 48 -18.318 -7.034 23.304 1.00 92.11 C \\\\nATOM 351 N VAL A 49 -17.948 -10.606 26.555 1.00 92.83 N \\\\nATOM 352 CA VAL A 49 -18.707 -10.674 27.811 1.00 92.83 C \\\\nATOM 353 C VAL A 49 -17.786 -11.020 28.981 1.00 92.83 C \\\\nATOM 354 CB VAL A 49 -19.863 -11.686 27.690 1.00 92.83 C \\\\nATOM 355 O VAL A 49 -17.889 -10.408 30.042 1.00 92.83 O \\\\nATOM 356 CG1 VAL A 49 -20.549 -11.969 29.034 1.00 92.83 C \\\\nATOM 357 CG2 VAL A 49 -20.943 -11.156 26.741 1.00 92.83 C \\\\nATOM 358 N LYS A 50 -16.836 -11.949 28.798 1.00 89.33 N \\\\nATOM 359 CA LYS A 50 -15.842 -12.282 29.831 1.00 89.33 C \\\\nATOM 360 C LYS A 50 -14.967 -11.079 30.205 1.00 89.33 C \\\\nATOM 361 CB LYS A 50 -14.997 -13.479 29.361 1.00 89.33 C \\\\nATOM 362 O LYS A 50 -14.634 -10.933 31.378 1.00 89.33 O \\\\nATOM 363 CG LYS A 50 -14.066 -14.014 30.465 1.00 89.33 C \\\\nATOM 364 CD LYS A 50 -13.259 -15.231 29.984 1.00 89.33 C \\\\nATOM 365 CE LYS A 50 -12.365 -15.766 31.114 1.00 89.33 C \\\\nATOM 366 NZ LYS A 50 -11.588 -16.967 30.703 1.00 89.33 N \\\\nATOM 367 N LYS A 51 -14.597 -10.230 29.238 1.00 88.71 N \\\\nATOM 368 CA LYS A 51 -13.817 -9.003 29.480 1.00 88.71 C \\\\nATOM 369 C LYS A 51 -14.659 -7.919 30.158 1.00 88.71 C \\\\nATOM 370 CB LYS A 51 -13.192 -8.490 28.171 1.00 88.71 C \\\\nATOM 371 O LYS A 51 -14.231 -7.385 31.174 1.00 88.71 O \\\\nATOM 372 CG LYS A 51 -12.089 -9.419 27.637 1.00 88.71 C \\\\nATOM 373 CD LYS A 51 -11.479 -8.842 26.352 1.00 88.71 C \\\\nATOM 374 CE LYS A 51 -10.367 -9.752 25.816 1.00 88.71 C \\\\nATOM 375 NZ LYS A 51 -9.566 -9.062 24.772 1.00 88.71 N \\\\nATOM 376 N LEU A 52 -15.874 -7.662 29.674 1.00 92.02 N \\\\nATOM 377 CA LEU A 52 -16.737 -6.597 30.202 1.00 92.02 C \\\\nATOM 378 C LEU A 52 -17.308 -6.897 31.591 1.00 92.02 C \\\\nATOM 379 CB LEU A 52 -17.871 -6.289 29.216 1.00 92.02 C \\\\nATOM 380 O LEU A 52 -17.553 -5.970 32.358 1.00 92.02 O \\\\nATOM 381 CG LEU A 52 -17.411 -5.796 27.835 1.00 92.02 C \\\\nATOM 382 CD1 LEU A 52 -18.646 -5.450 27.015 1.00 92.02 C \\\\nATOM 383 CD2 LEU A 52 -16.510 -4.565 27.878 1.00 92.02 C \\\\nATOM 384 N LYS A 53 -17.466 -8.177 31.956 1.00 90.21 N \\\\nATOM 385 CA LYS A 53 -17.799 -8.568 33.336 1.00 90.21 C \\\\nATOM 386 C LYS A 53 -16.706 -8.190 34.335 1.00 90.21 C \\\\nATOM 387 CB LYS A 53 -18.079 -10.075 33.425 1.00 90.21 C \\\\nATOM 388 O LYS A 53 -17.027 -7.907 35.480 1.00 90.21 O \\\\nATOM 389 CG LYS A 53 -19.488 -10.416 32.930 1.00 90.21 C \\\\nATOM 390 CD LYS A 53 -19.791 -11.901 33.151 1.00 90.21 C \\\\nATOM 391 CE LYS A 53 -21.242 -12.185 32.753 1.00 90.21 C \\\\nATOM 392 NZ LYS A 53 -21.682 -13.518 33.232 1.00 90.21 N \\\\nATOM 393 N LYS A 54 -15.435 -8.178 33.916 1.00 86.28 N \\\\nATOM 394 CA LYS A 54 -14.317 -7.762 34.778 1.00 86.28 C \\\\nATOM 395 C LYS A 54 -14.244 -6.244 34.944 1.00 86.28 C \\\\nATOM 396 CB LYS A 54 -12.983 -8.291 34.238 1.00 86.28 C \\\\nATOM 397 O LYS A 54 -13.834 -5.789 36.000 1.00 86.28 O \\\\nATOM 398 CG LYS A 54 -12.859 -9.818 34.308 1.00 86.28 C \\\\nATOM 399 CD LYS A 54 -11.468 -10.222 33.806 1.00 86.28 C \\\\nATOM 400 CE LYS A 54 -11.221 -11.720 33.988 1.00 86.28 C \\\\nATOM 401 NZ LYS A 54 -9.779 -12.030 33.803 1.00 86.28 N \\\\nATOM 402 N THR A 55 -14.635 -5.479 33.922 1.00 85.96 N \\\\nATOM 403 CA THR A 55 -14.583 -4.005 33.936 1.00 85.96 C \\\\nATOM 404 C THR A 55 -15.893 -3.341 34.372 1.00 85.96 C \\\\nATOM 405 CB THR A 55 -14.146 -3.452 32.568 1.00 85.96 C \\\\nATOM 406 O THR A 55 -15.940 -2.122 34.496 1.00 85.96 O \\\\nATOM 407 CG2 THR A 55 -12.763 -3.949 32.150 1.00 85.96 C \\\\nATOM 408 OG1 THR A 55 -15.038 -3.846 31.547 1.00 85.96 O \\\\nATOM 409 N GLY A 56 -16.972 -4.108 34.575 1.00 88.71 N \\\\nATOM 410 CA GLY A 56 -18.290 -3.575 34.942 1.00 88.71 C \\\\nATOM 411 C GLY A 56 -18.988 -2.791 33.821 1.00 88.71 C \\\\nATOM 412 O GLY A 56 -19.892 -2.010 34.088 1.00 88.71 O \\\\nATOM 413 N ARG A 57 -18.578 -2.970 32.557 1.00 89.65 N \\\\nATOM 414 CA ARG A 57 -19.094 -2.215 31.392 1.00 89.65 C \\\\nATOM 415 C ARG A 57 -20.141 -2.977 30.570 1.00 89.65 C \\\\nATOM 416 CB ARG A 57 -17.914 -1.754 30.516 1.00 89.65 C \\\\nATOM 417 O ARG A 57 -20.518 -2.529 29.490 1.00 89.65 O \\\\nATOM 418 CG ARG A 57 -16.913 -0.808 31.193 1.00 89.65 C \\\\nATOM 419 CD ARG A 57 -17.510 0.564 31.522 1.00 89.65 C \\\\nATOM 420 NE ARG A 57 -16.465 1.467 32.040 1.00 89.65 N \\\\nATOM 421 NH1 ARG A 57 -17.446 3.467 31.478 1.00 89.65 N \\\\nATOM 422 NH2 ARG A 57 -15.450 3.456 32.477 1.00 89.65 N \\\\nATOM 423 CZ ARG A 57 -16.463 2.787 32.001 1.00 89.65 C \\\\nATOM 424 N LEU A 58 -20.583 -4.146 31.039 1.00 92.08 N \\\\nATOM 425 CA LEU A 58 -21.513 -5.006 30.299 1.00 92.08 C \\\\nATOM 426 C LEU A 58 -22.893 -4.354 30.123 1.00 92.08 C \\\\nATOM 427 CB LEU A 58 -21.603 -6.366 31.010 1.00 92.08 C \\\\nATOM 428 O LEU A 58 -23.426 -4.374 29.017 1.00 92.08 O \\\\nATOM 429 CG LEU A 58 -22.493 -7.403 30.296 1.00 92.08 C \\\\nATOM 430 CD1 LEU A 58 -21.978 -7.747 28.893 1.00 92.08 C \\\\nATOM 431 CD2 LEU A 58 -22.483 -8.687 31.132 1.00 92.08 C \\\\nATOM 432 N ASP A 59 -23.422 -3.728 31.174 1.00 92.16 N \\\\nATOM 433 CA ASP A 59 -24.736 -3.072 31.134 1.00 92.16 C \\\\nATOM 434 C ASP A 59 -24.733 -1.855 30.197 1.00 92.16 C \\\\nATOM 435 CB ASP A 59 -25.151 -2.655 32.554 1.00 92.16 C \\\\nATOM 436 O ASP A 59 -25.700 -1.618 29.476 1.00 92.16 O \\\\nATOM 437 CG ASP A 59 -25.249 -3.839 33.523 1.00 92.16 C \\\\nATOM 438 OD1 ASP A 59 -25.561 -4.960 33.061 1.00 92.16 O \\\\nATOM 439 OD2 ASP A 59 -24.929 -3.629 34.711 1.00 92.16 O \\\\nATOM 440 N GLU A 60 -23.615 -1.123 30.132 1.00 92.46 N \\\\nATOM 441 CA GLU A 60 -23.435 -0.012 29.188 1.00 92.46 C \\\\nATOM 442 C GLU A 60 -23.424 -0.503 27.732 1.00 92.46 C \\\\nATOM 443 CB GLU A 60 -22.143 0.763 29.502 1.00 92.46 C \\\\nATOM 444 O GLU A 60 -24.003 0.152 26.867 1.00 92.46 O \\\\nATOM 445 CG GLU A 60 -22.169 1.524 30.841 1.00 92.46 C \\\\nATOM 446 CD GLU A 60 -23.135 2.728 30.898 1.00 92.46 C \\\\nATOM 447 OE1 GLU A 60 -23.315 3.275 32.013 1.00 92.46 O \\\\nATOM 448 OE2 GLU A 60 -23.622 3.188 29.838 1.00 92.46 O \\\\nATOM 449 N LEU A 61 -22.840 -1.678 27.449 1.00 93.87 N \\\\nATOM 450 CA LEU A 61 -22.908 -2.284 26.114 1.00 93.87 C \\\\nATOM 451 C LEU A 61 -24.337 -2.705 25.755 1.00 93.87 C \\\\nATOM 452 CB LEU A 61 -21.944 -3.481 26.011 1.00 93.87 C \\\\nATOM 453 O LEU A 61 -24.794 -2.415 24.650 1.00 93.87 O \\\\nATOM 454 CG LEU A 61 -21.969 -4.148 24.618 1.00 93.87 C \\\\nATOM 455 CD1 LEU A 61 -21.420 -3.231 23.519 1.00 93.87 C \\\\nATOM 456 CD2 LEU A 61 -21.150 -5.433 24.618 1.00 93.87 C \\\\nATOM 457 N GLU A 62 -25.045 -3.378 26.668 1.00 93.54 N \\\\nATOM 458 CA GLU A 62 -26.443 -3.769 26.441 1.00 93.54 C \\\\nATOM 459 C GLU A 62 -27.325 -2.540 26.204 1.00 93.54 C \\\\nATOM 460 CB GLU A 62 -26.995 -4.589 27.621 1.00 93.54 C \\\\nATOM 461 O GLU A 62 -28.126 -2.525 25.266 1.00 93.54 O \\\\nATOM 462 CG GLU A 62 -26.402 -6.004 27.667 1.00 93.54 C \\\\nATOM 463 CD GLU A 62 -27.088 -6.953 28.667 1.00 93.54 C \\\\nATOM 464 OE1 GLU A 62 -26.574 -8.083 28.830 1.00 93.54 O \\\\nATOM 465 OE2 GLU A 62 -28.202 -6.695 29.181 1.00 93.54 O \\\\nATOM 466 N LYS A 63 -27.129 -1.479 26.994 1.00 93.28 N \\\\nATOM 467 CA LYS A 63 -27.811 -0.197 26.818 1.00 93.28 C \\\\nATOM 468 C LYS A 63 -27.486 0.430 25.467 1.00 93.28 C \\\\nATOM 469 CB LYS A 63 -27.437 0.728 27.983 1.00 93.28 C \\\\nATOM 470 O LYS A 63 -28.412 0.847 24.775 1.00 93.28 O \\\\nATOM 471 CG LYS A 63 -28.233 2.040 27.961 1.00 93.28 C \\\\nATOM 472 CD LYS A 63 -27.803 2.920 29.138 1.00 93.28 C \\\\nATOM 473 CE LYS A 63 -28.577 4.240 29.125 1.00 93.28 C \\\\nATOM 474 NZ LYS A 63 -28.150 5.106 30.250 1.00 93.28 N \\\\nATOM 475 N ALA A 64 -26.217 0.479 25.066 1.00 93.52 N \\\\nATOM 476 CA ALA A 64 -25.806 1.046 23.784 1.00 93.52 C \\\\nATOM 477 C ALA A 64 -26.443 0.309 22.596 1.00 93.52 C \\\\nATOM 478 CB ALA A 64 -24.277 1.032 23.700 1.00 93.52 C \\\\nATOM 479 O ALA A 64 -27.006 0.953 21.716 1.00 93.52 O \\\\nATOM 480 N ILE A 65 -26.426 -1.029 22.605 1.00 93.03 N \\\\nATOM 481 CA ILE A 65 -27.017 -1.851 21.537 1.00 93.03 C \\\\nATOM 482 C ILE A 65 -28.545 -1.735 21.510 1.00 93.03 C \\\\nATOM 483 CB ILE A 65 -26.532 -3.315 21.639 1.00 93.03 C \\\\nATOM 484 O ILE A 65 -29.130 -1.622 20.437 1.00 93.03 O \\\\nATOM 485 CG1 ILE A 65 -25.006 -3.390 21.390 1.00 93.03 C \\\\nATOM 486 CG2 ILE A 65 -27.264 -4.212 20.620 1.00 93.03 C \\\\nATOM 487 CD1 ILE A 65 -24.401 -4.746 21.764 1.00 93.03 C \\\\nATOM 488 N THR A 66 -29.194 -1.718 22.676 1.00 92.60 N \\\\nATOM 489 CA THR A 66 -30.662 -1.653 22.763 1.00 92.60 C \\\\nATOM 490 C THR A 66 -31.198 -0.273 22.379 1.00 92.60 C \\\\nATOM 491 CB THR A 66 -31.146 -2.028 24.174 1.00 92.60 C \\\\nATOM 492 O THR A 66 -32.177 -0.171 21.647 1.00 92.60 O \\\\nATOM 493 CG2 THR A 66 -32.667 -2.135 24.269 1.00 92.60 C \\\\nATOM 494 OG1 THR A 66 -30.633 -3.284 24.551 1.00 92.60 O \\\\nATOM 495 N THR A 67 -30.559 0.797 22.863 1.00 92.64 N \\\\nATOM 496 CA THR A 67 -31.003 2.185 22.623 1.00 92.64 C \\\\nATOM 497 C THR A 67 -30.495 2.773 21.314 1.00 92.64 C \\\\nATOM 498 CB THR A 67 -30.606 3.133 23.765 1.00 92.64 C \\\\nATOM 499 O THR A 67 -31.008 3.799 20.880 1.00 92.64 O \\\\nATOM 500 CG2 THR A 67 -31.188 2.700 25.110 1.00 92.64 C \\\\nATOM 501 OG1 THR A 67 -29.206 3.215 23.915 1.00 92.64 O \\\\nATOM 502 N GLN A 68 -29.488 2.148 20.700 1.00 91.97 N \\\\nATOM 503 CA GLN A 68 -28.839 2.620 19.478 1.00 91.97 C \\\\nATOM 504 C GLN A 68 -28.338 4.071 19.573 1.00 91.97 C \\\\nATOM 505 CB GLN A 68 -29.736 2.359 18.258 1.00 91.97 C \\\\nATOM 506 O GLN A 68 -28.393 4.832 18.609 1.00 91.97 O \\\\nATOM 507 CG GLN A 68 -30.251 0.912 18.216 1.00 91.97 C \\\\nATOM 508 CD GLN A 68 -30.759 0.500 16.843 1.00 91.97 C \\\\nATOM 509 NE2 GLN A 68 -31.744 -0.367 16.782 1.00 91.97 N \\\\nATOM 510 OE1 GLN A 68 -30.267 0.904 15.800 1.00 91.97 O \\\\nATOM 511 N ASN A 69 -27.872 4.466 20.760 1.00 89.65 N \\\\nATOM 512 CA ASN A 69 -27.577 5.856 21.090 1.00 89.65 C \\\\nATOM 513 C ASN A 69 -26.068 6.099 21.251 1.00 89.65 C \\\\nATOM 514 CB ASN A 69 -28.402 6.229 22.331 1.00 89.65 C \\\\nATOM 515 O ASN A 69 -25.402 5.468 22.080 1.00 89.65 O \\\\nATOM 516 CG ASN A 69 -28.392 7.714 22.640 1.00 89.65 C \\\\nATOM 517 ND2 ASN A 69 -29.345 8.179 23.410 1.00 89.65 N \\\\nATOM 518 OD1 ASN A 69 -27.539 8.474 22.219 1.00 89.65 O \\\\nATOM 519 N CYS A 70 -25.540 7.065 20.499 1.00 90.18 N \\\\nATOM 520 CA CYS A 70 -24.140 7.490 20.554 1.00 90.18 C \\\\nATOM 521 C CYS A 70 -23.754 8.189 21.873 1.00 90.18 C \\\\nATOM 522 CB CYS A 70 -23.859 8.383 19.337 1.00 90.18 C \\\\nATOM 523 O CYS A 70 -22.586 8.165 22.245 1.00 90.18 O \\\\nATOM 524 SG CYS A 70 -24.988 9.806 19.301 1.00 90.18 S \\\\nATOM 525 N ASN A 71 -24.720 8.727 22.625 1.00 91.25 N \\\\nATOM 526 CA ASN A 71 -24.501 9.393 23.918 1.00 91.25 C \\\\nATOM 527 C ASN A 71 -24.326 8.416 25.098 1.00 91.25 C \\\\nATOM 528 CB ASN A 71 -25.653 10.379 24.174 1.00 91.25 C \\\\nATOM 529 O ASN A 71 -24.219 8.830 26.252 1.00 91.25 O \\\\nATOM 530 CG ASN A 71 -25.709 11.485 23.138 1.00 91.25 C \\\\nATOM 531 ND2 ASN A 71 -26.879 11.845 22.666 1.00 91.25 N \\\\nATOM 532 OD1 ASN A 71 -24.702 12.045 22.745 1.00 91.25 O \\\\nATOM 533 N THR A 72 -24.336 7.107 24.840 1.00 92.41 N \\\\nATOM 534 CA THR A 72 -23.986 6.097 25.850 1.00 92.41 C \\\\nATOM 535 C THR A 72 -22.507 6.193 26.239 1.00 92.41 C \\\\nATOM 536 CB THR A 72 -24.354 4.682 25.377 1.00 92.41 C \\\\nATOM 537 O THR A 72 -21.696 6.758 25.505 1.00 92.41 O \\\\nATOM 538 CG2 THR A 72 -25.874 4.478 25.331 1.00 92.41 C \\\\nATOM 539 OG1 THR A 72 -23.835 4.411 24.093 1.00 92.41 O \\\\nATOM 540 N LYS A 73 -22.125 5.663 27.410 1.00 93.98 N \\\\nATOM 541 CA LYS A 73 -20.726 5.719 27.862 1.00 93.98 C \\\\nATOM 542 C LYS A 73 -19.822 4.856 26.976 1.00 93.98 C \\\\nATOM 543 CB LYS A 73 -20.611 5.312 29.339 1.00 93.98 C \\\\nATOM 544 O LYS A 73 -20.266 3.904 26.332 1.00 93.98 O \\\\nATOM 545 CG LYS A 73 -21.291 6.319 30.278 1.00 93.98 C \\\\nATOM 546 CD LYS A 73 -21.077 5.906 31.737 1.00 93.98 C \\\\nATOM 547 CE LYS A 73 -21.893 6.794 32.679 1.00 93.98 C \\\\nATOM 548 NZ LYS A 73 -21.996 6.174 34.021 1.00 93.98 N \\\\nATOM 549 N CYS A 74 -18.523 5.163 26.980 1.00 94.08 N \\\\nATOM 550 CA CYS A 74 -17.531 4.311 26.328 1.00 94.08 C \\\\nATOM 551 C CYS A 74 -17.552 2.905 26.948 1.00 94.08 C \\\\nATOM 552 CB CYS A 74 -16.129 4.936 26.412 1.00 94.08 C \\\\nATOM 553 O CYS A 74 -17.532 2.745 28.173 1.00 94.08 O \\\\nATOM 554 SG CYS A 74 -16.008 6.429 25.382 1.00 94.08 S \\\\nATOM 555 N VAL A 75 -17.562 1.888 26.088 1.00 94.76 N \\\\nATOM 556 CA VAL A 75 -17.382 0.483 26.468 1.00 94.76 C \\\\nATOM 557 C VAL A 75 -15.969 0.112 26.067 1.00 94.76 C \\\\nATOM 558 CB VAL A 75 -18.406 -0.431 25.770 1.00 94.76 C \\\\nATOM 559 O VAL A 75 -15.702 -0.009 24.878 1.00 94.76 O \\\\nATOM 560 CG1 VAL A 75 -18.184 -1.901 26.146 1.00 94.76 C \\\\nATOM 561 CG2 VAL A 75 -19.841 -0.057 26.150 1.00 94.76 C \\\\nATOM 562 N THR A 76 -15.059 -0.032 27.023 1.00 93.46 N \\\\nATOM 563 CA THR A 76 -13.633 -0.205 26.735 1.00 93.46 C \\\\nATOM 564 C THR A 76 -13.158 -1.636 26.965 1.00 93.46 C \\\\nATOM 565 CB THR A 76 -12.778 0.807 27.509 1.00 93.46 C \\\\nATOM 566 O THR A 76 -13.692 -2.372 27.801 1.00 93.46 O \\\\nATOM 567 CG2 THR A 76 -13.114 2.240 27.106 1.00 93.46 C \\\\nATOM 568 OG1 THR A 76 -12.960 0.698 28.899 1.00 93.46 O \\\\nATOM 569 N ILE A 77 -12.156 -2.050 26.189 1.00 90.10 N \\\\nATOM 570 CA ILE A 77 -11.353 -3.243 26.468 1.00 90.10 C \\\\nATOM 571 C ILE A 77 -9.863 -2.894 26.371 1.00 90.10 C \\\\nATOM 572 CB ILE A 77 -11.712 -4.433 25.550 1.00 90.10 C \\\\nATOM 573 O ILE A 77 -9.518 -2.003 25.590 1.00 90.10 O \\\\nATOM 574 CG1 ILE A 77 -11.311 -4.212 24.075 1.00 90.10 C \\\\nATOM 575 CG2 ILE A 77 -13.194 -4.824 25.678 1.00 90.10 C \\\\nATOM 576 CD1 ILE A 77 -11.446 -5.492 23.246 1.00 90.10 C \\\\nATOM 577 N PRO A 78 -8.974 -3.630 27.063 1.00 85.17 N \\\\nATOM 578 CA PRO A 78 -7.536 -3.446 26.912 1.00 85.17 C \\\\nATOM 579 C PRO A 78 -7.113 -3.584 25.447 1.00 85.17 C \\\\nATOM 580 CB PRO A 78 -6.879 -4.504 27.802 1.00 85.17 C \\\\nATOM 581 O PRO A 78 -7.439 -4.582 24.787 1.00 85.17 O \\\\nATOM 582 CG PRO A 78 -7.942 -4.768 28.866 1.00 85.17 C \\\\nATOM 583 CD PRO A 78 -9.253 -4.611 28.100 1.00 85.17 C \\\\nATOM 584 N SER A 79 -6.401 -2.580 24.949 1.00 71.62 N \\\\nATOM 585 CA SER A 79 -5.681 -2.636 23.687 1.00 71.62 C \\\\nATOM 586 C SER A 79 -4.462 -3.539 23.896 1.00 71.62 C \\\\nATOM 587 CB SER A 79 -5.308 -1.217 23.219 1.00 71.62 C \\\\nATOM 588 O SER A 79 -3.763 -3.440 24.900 1.00 71.62 O \\\\nATOM 589 OG SER A 79 -4.110 -0.770 23.807 1.00 71.62 O \\\\nATOM 590 N THR A 80 -4.172 -4.464 22.983 1.00 59.90 N \\\\nATOM 591 CA THR A 80 -2.960 -5.301 23.097 1.00 59.90 C \\\\nATOM 592 C THR A 80 -1.685 -4.537 22.707 1.00 59.90 C \\\\nATOM 593 CB THR A 80 -3.101 -6.618 22.320 1.00 59.90 C \\\\nATOM 594 O THR A 80 -0.674 -5.158 22.406 1.00 59.90 O \\\\nATOM 595 CG2 THR A 80 -4.223 -7.497 22.877 1.00 59.90 C \\\\nATOM 596 OG1 THR A 80 -3.398 -6.369 20.967 1.00 59.90 O \\\\nATOM 597 N CYS A 81 -1.736 -3.200 22.677 1.00 47.74 N \\\\nATOM 598 CA CYS A 81 -0.661 -2.323 22.214 1.00 47.74 C \\\\nATOM 599 C CYS A 81 0.280 -1.863 23.350 1.00 47.74 C \\\\nATOM 600 CB CYS A 81 -1.319 -1.126 21.503 1.00 47.74 C \\\\nATOM 601 O CYS A 81 1.355 -1.333 23.082 1.00 47.74 O \\\\nATOM 602 SG CYS A 81 -0.392 -0.705 20.001 1.00 47.74 S \\\\nATOM 603 N SER A 82 -0.104 -2.063 24.615 1.00 37.47 N \\\\nATOM 604 CA SER A 82 0.460 -1.334 25.764 1.00 37.47 C \\\\nATOM 605 C SER A 82 1.840 -1.773 26.281 1.00 37.47 C \\\\nATOM 606 CB SER A 82 -0.560 -1.324 26.906 1.00 37.47 C \\\\nATOM 607 O SER A 82 2.295 -1.221 27.273 1.00 37.47 O \\\\nATOM 608 OG SER A 82 -1.732 -0.678 26.466 1.00 37.47 O \\\\nATOM 609 N GLU A 83 2.556 -2.707 25.645 1.00 31.77 N \\\\nATOM 610 CA GLU A 83 3.882 -3.150 26.139 1.00 31.77 C \\\\nATOM 611 C GLU A 83 5.094 -2.591 25.370 1.00 31.77 C \\\\nATOM 612 CB GLU A 83 3.915 -4.680 26.315 1.00 31.77 C \\\\nATOM 613 O GLU A 83 6.224 -2.919 25.710 1.00 31.77 O \\\\nATOM 614 CG GLU A 83 3.294 -5.082 27.666 1.00 31.77 C \\\\nATOM 615 CD GLU A 83 3.256 -6.598 27.899 1.00 31.77 C \\\\nATOM 616 OE1 GLU A 83 2.828 -7.025 29.001 1.00 31.77 O \\\\nATOM 617 OE2 GLU A 83 3.452 -7.382 26.936 1.00 31.77 O \\\\nATOM 618 N ILE A 84 4.906 -1.712 24.376 1.00 36.42 N \\\\nATOM 619 CA ILE A 84 6.024 -1.180 23.555 1.00 36.42 C \\\\nATOM 620 C ILE A 84 6.279 0.324 23.782 1.00 36.42 C \\\\nATOM 621 CB ILE A 84 5.843 -1.596 22.072 1.00 36.42 C \\\\nATOM 622 O ILE A 84 7.289 0.856 23.338 1.00 36.42 O \\\\nATOM 623 CG1 ILE A 84 5.726 -3.139 21.977 1.00 36.42 C \\\\nATOM 624 CG2 ILE A 84 6.992 -1.116 21.162 1.00 36.42 C \\\\nATOM 625 CD1 ILE A 84 5.420 -3.649 20.568 1.00 36.42 C \\\\nATOM 626 N TRP A 85 5.426 1.014 24.546 1.00 34.71 N \\\\nATOM 627 CA TRP A 85 5.549 2.464 24.793 1.00 34.71 C \\\\nATOM 628 C TRP A 85 5.761 2.828 26.271 1.00 34.71 C \\\\nATOM 629 CB TRP A 85 4.381 3.188 24.113 1.00 34.71 C \\\\nATOM 630 O TRP A 85 5.601 3.981 26.669 1.00 34.71 O \\\\nATOM 631 CG TRP A 85 4.342 2.970 22.629 1.00 34.71 C \\\\nATOM 632 CD1 TRP A 85 3.536 2.101 21.977 1.00 34.71 C \\\\nATOM 633 CD2 TRP A 85 5.203 3.561 21.607 1.00 34.71 C \\\\nATOM 634 CE2 TRP A 85 4.849 3.004 20.342 1.00 34.71 C \\\\nATOM 635 CE3 TRP A 85 6.259 4.499 21.624 1.00 34.71 C \\\\nATOM 636 NE1 TRP A 85 3.833 2.116 20.628 1.00 34.71 N \\\\nATOM 637 CH2 TRP A 85 6.542 4.307 19.203 1.00 34.71 C \\\\nATOM 638 CZ2 TRP A 85 5.500 3.365 19.152 1.00 34.71 C \\\\nATOM 639 CZ3 TRP A 85 6.920 4.870 20.436 1.00 34.71 C \\\\nATOM 640 N GLY A 86 6.149 1.843 27.086 1.00 29.44 N \\\\nATOM 641 CA GLY A 86 6.509 2.026 28.486 1.00 29.44 C \\\\nATOM 642 C GLY A 86 7.871 2.694 28.626 1.00 29.44 C \\\\nATOM 643 O GLY A 86 8.901 2.051 28.456 1.00 29.44 O \\\\nATOM 644 N LEU A 87 7.829 3.989 28.932 1.00 30.48 N \\\\nATOM 645 CA LEU A 87 8.833 4.761 29.663 1.00 30.48 C \\\\nATOM 646 C LEU A 87 9.878 3.875 30.357 1.00 30.48 C \\\\nATOM 647 CB LEU A 87 8.064 5.590 30.711 1.00 30.48 C \\\\nATOM 648 O LEU A 87 9.633 3.302 31.418 1.00 30.48 O \\\\nATOM 649 CG LEU A 87 7.241 6.738 30.097 1.00 30.48 C \\\\nATOM 650 CD1 LEU A 87 6.038 7.073 30.977 1.00 30.48 C \\\\nATOM 651 CD2 LEU A 87 8.101 7.992 29.942 1.00 30.48 C \\\\nATOM 652 N SER A 88 11.063 3.814 29.760 1.00 25.22 N \\\\nATOM 653 CA SER A 88 12.293 3.451 30.440 1.00 25.22 C \\\\nATOM 654 C SER A 88 12.496 4.428 31.599 1.00 25.22 C \\\\nATOM 655 CB SER A 88 13.476 3.470 29.450 1.00 25.22 C \\\\nATOM 656 O SER A 88 12.966 5.549 31.422 1.00 25.22 O \\\\nATOM 657 OG SER A 88 13.191 4.184 28.252 1.00 25.22 O \\\\nATOM 658 N THR A 89 12.136 4.009 32.810 1.00 30.16 N \\\\nATOM 659 CA THR A 89 12.752 4.561 34.014 1.00 30.16 C \\\\nATOM 660 C THR A 89 14.230 4.167 33.984 1.00 30.16 C \\\\nATOM 661 CB THR A 89 12.091 4.035 35.295 1.00 30.16 C \\\\nATOM 662 O THR A 89 14.527 2.970 33.921 1.00 30.16 O \\\\nATOM 663 CG2 THR A 89 10.757 4.732 35.552 1.00 30.16 C \\\\nATOM 664 OG1 THR A 89 11.841 2.651 35.201 1.00 30.16 O \\\\nATOM 665 N PRO A 90 15.173 5.124 34.002 1.00 28.90 N \\\\nATOM 666 CA PRO A 90 16.584 4.803 34.088 1.00 28.90 C \\\\nATOM 667 C PRO A 90 16.835 4.377 35.529 1.00 28.90 C \\\\nATOM 668 CB PRO A 90 17.313 6.095 33.707 1.00 28.90 C \\\\nATOM 669 O PRO A 90 16.705 5.202 36.424 1.00 28.90 O \\\\nATOM 670 CG PRO A 90 16.362 7.203 34.168 1.00 28.90 C \\\\nATOM 671 CD PRO A 90 14.973 6.563 34.105 1.00 28.90 C \\\\nATOM 672 N ASN A 91 17.056 3.084 35.752 1.00 29.36 N \\\\nATOM 673 CA ASN A 91 17.805 2.494 36.867 1.00 29.36 C \\\\nATOM 674 C ASN A 91 17.425 1.019 36.949 1.00 29.36 C \\\\nATOM 675 CB ASN A 91 17.552 3.179 38.232 1.00 29.36 C \\\\nATOM 676 O ASN A 91 16.373 0.683 37.484 1.00 29.36 O \\\\nATOM 677 CG ASN A 91 18.396 4.431 38.428 1.00 29.36 C \\\\nATOM 678 ND2 ASN A 91 18.022 5.292 39.346 1.00 29.36 N \\\\nATOM 679 OD1 ASN A 91 19.401 4.654 37.771 1.00 29.36 O \\\\nATOM 680 N THR A 92 18.254 0.164 36.353 1.00 32.37 N \\\\nATOM 681 CA THR A 92 18.830 -1.072 36.920 1.00 32.37 C \\\\nATOM 682 C THR A 92 19.379 -1.865 35.730 1.00 32.37 C \\\\nATOM 683 CB THR A 92 17.909 -1.961 37.789 1.00 32.37 C \\\\nATOM 684 O THR A 92 18.694 -2.679 35.117 1.00 32.37 O \\\\nATOM 685 CG2 THR A 92 18.737 -3.005 38.536 1.00 32.37 C \\\\nATOM 686 OG1 THR A 92 17.303 -1.246 38.836 1.00 32.37 O \\\\nATOM 687 N ILE A 93 20.615 -1.541 35.349 1.00 28.03 N \\\\nATOM 688 CA ILE A 93 21.522 -2.503 34.722 1.00 28.03 C \\\\nATOM 689 C ILE A 93 21.924 -3.445 35.857 1.00 28.03 C \\\\nATOM 690 CB ILE A 93 22.731 -1.736 34.106 1.00 28.03 C \\\\nATOM 691 O ILE A 93 22.379 -2.948 36.879 1.00 28.03 O \\\\nATOM 692 CG1 ILE A 93 22.439 -1.434 32.620 1.00 28.03 C \\\\nATOM 693 CG2 ILE A 93 24.089 -2.445 34.256 1.00 28.03 C \\\\nATOM 694 CD1 ILE A 93 23.420 -0.446 31.969 1.00 28.03 C \\\\nATOM 695 N ASP A 94 21.669 -4.747 35.726 1.00 28.87 N \\\\nATOM 696 CA ASP A 94 22.699 -5.776 35.917 1.00 28.87 C \\\\nATOM 697 C ASP A 94 22.152 -7.210 35.825 1.00 28.87 C \\\\nATOM 698 CB ASP A 94 23.527 -5.601 37.216 1.00 28.87 C \\\\nATOM 699 O ASP A 94 21.021 -7.503 36.202 1.00 28.87 O \\\\nATOM 700 CG ASP A 94 24.797 -4.765 36.982 1.00 28.87 C \\\\nATOM 701 OD1 ASP A 94 25.372 -4.904 35.874 1.00 28.87 O \\\\nATOM 702 OD2 ASP A 94 25.229 -4.050 37.912 1.00 28.87 O \\\\nATOM 703 N GLN A 95 23.048 -8.084 35.356 1.00 28.34 N \\\\nATOM 704 CA GLN A 95 23.051 -9.550 35.431 1.00 28.34 C \\\\nATOM 705 C GLN A 95 22.244 -10.349 34.398 1.00 28.34 C \\\\nATOM 706 CB GLN A 95 22.909 -10.039 36.878 1.00 28.34 C \\\\nATOM 707 O GLN A 95 21.122 -10.808 34.592 1.00 28.34 O \\\\nATOM 708 CG GLN A 95 24.224 -9.778 37.628 1.00 28.34 C \\\\nATOM 709 CD GLN A 95 24.151 -10.082 39.115 1.00 28.34 C \\\\nATOM 710 NE2 GLN A 95 25.259 -9.974 39.813 1.00 28.34 N \\\\nATOM 711 OE1 GLN A 95 23.125 -10.391 39.695 1.00 28.34 O \\\\nATOM 712 N TRP A 96 22.942 -10.621 33.298 1.00 28.28 N \\\\nATOM 713 CA TRP A 96 22.775 -11.798 32.453 1.00 28.28 C \\\\nATOM 714 C TRP A 96 23.284 -13.016 33.228 1.00 28.28 C \\\\nATOM 715 CB TRP A 96 23.558 -11.586 31.132 1.00 28.28 C \\\\nATOM 716 O TRP A 96 24.493 -13.222 33.312 1.00 28.28 O \\\\nATOM 717 CG TRP A 96 24.418 -10.350 31.070 1.00 28.28 C \\\\nATOM 718 CD1 TRP A 96 23.944 -9.116 30.787 1.00 28.28 C \\\\nATOM 719 CD2 TRP A 96 25.832 -10.165 31.407 1.00 28.28 C \\\\nATOM 720 CE2 TRP A 96 26.137 -8.773 31.296 1.00 28.28 C \\\\nATOM 721 CE3 TRP A 96 26.882 -11.012 31.826 1.00 28.28 C \\\\nATOM 722 NE1 TRP A 96 24.950 -8.184 30.923 1.00 28.28 N \\\\nATOM 723 CH2 TRP A 96 28.435 -9.124 31.956 1.00 28.28 C \\\\nATOM 724 CZ2 TRP A 96 27.409 -8.249 31.563 1.00 28.28 C \\\\nATOM 725 CZ3 TRP A 96 28.169 -10.499 32.089 1.00 28.28 C \\\\nATOM 726 N ASP A 97 22.372 -13.816 33.783 1.00 30.80 N \\\\nATOM 727 CA ASP A 97 22.724 -15.109 34.364 1.00 30.80 C \\\\nATOM 728 C ASP A 97 22.295 -16.277 33.477 1.00 30.80 C \\\\nATOM 729 CB ASP A 97 22.293 -15.250 35.836 1.00 30.80 C \\\\nATOM 730 O ASP A 97 21.179 -16.376 32.964 1.00 30.80 O \\\\nATOM 731 CG ASP A 97 23.484 -15.319 36.808 1.00 30.80 C \\\\nATOM 732 OD1 ASP A 97 24.590 -15.712 36.366 1.00 30.80 O \\\\nATOM 733 OD2 ASP A 97 23.262 -15.039 38.003 1.00 30.80 O \\\\nATOM 734 N THR A 98 23.271 -17.153 33.269 1.00 31.38 N \\\\nATOM 735 CA THR A 98 23.314 -18.206 32.260 1.00 31.38 C \\\\nATOM 736 C THR A 98 22.985 -19.534 32.926 1.00 31.38 C \\\\nATOM 737 CB THR A 98 24.722 -18.229 31.618 1.00 31.38 C \\\\nATOM 738 O THR A 98 23.879 -20.339 33.113 1.00 31.38 O \\\\nATOM 739 CG2 THR A 98 24.846 -19.152 30.402 1.00 31.38 C \\\\nATOM 740 OG1 THR A 98 25.071 -16.945 31.158 1.00 31.38 O \\\\nATOM 741 N THR A 99 21.741 -19.796 33.338 1.00 33.23 N \\\\nATOM 742 CA THR A 99 21.313 -21.157 33.728 1.00 33.23 C \\\\nATOM 743 C THR A 99 19.787 -21.311 33.746 1.00 33.23 C \\\\nATOM 744 CB THR A 99 21.846 -21.623 35.107 1.00 33.23 C \\\\nATOM 745 O THR A 99 19.082 -20.562 34.402 1.00 33.23 O \\\\nATOM 746 CG2 THR A 99 23.257 -22.219 35.127 1.00 33.23 C \\\\nATOM 747 OG1 THR A 99 21.824 -20.599 36.064 1.00 33.23 O \\\\nATOM 748 N GLY A 100 19.296 -22.335 33.041 1.00 27.30 N \\\\nATOM 749 CA GLY A 100 18.237 -23.241 33.502 1.00 27.30 C \\\\nATOM 750 C GLY A 100 16.857 -22.696 33.906 1.00 27.30 C \\\\nATOM 751 O GLY A 100 16.671 -22.157 34.986 1.00 27.30 O \\\\nATOM 752 N LEU A 101 15.853 -23.125 33.132 1.00 27.46 N \\\\nATOM 753 CA LEU A 101 14.538 -23.565 33.627 1.00 27.46 C \\\\nATOM 754 C LEU A 101 13.613 -22.492 34.228 1.00 27.46 C \\\\nATOM 755 CB LEU A 101 14.733 -24.746 34.612 1.00 27.46 C \\\\nATOM 756 O LEU A 101 13.380 -22.483 35.428 1.00 27.46 O \\\\nATOM 757 CG LEU A 101 15.334 -26.022 34.005 1.00 27.46 C \\\\nATOM 758 CD1 LEU A 101 15.954 -26.888 35.100 1.00 27.46 C \\\\nATOM 759 CD2 LEU A 101 14.255 -26.838 33.290 1.00 27.46 C \\\\nATOM 760 N TYR A 102 12.916 -21.736 33.373 1.00 30.22 N \\\\nATOM 761 CA TYR A 102 11.531 -21.351 33.669 1.00 30.22 C \\\\nATOM 762 C TYR A 102 10.646 -21.485 32.430 1.00 30.22 C \\\\nATOM 763 CB TYR A 102 11.414 -19.976 34.345 1.00 30.22 C \\\\nATOM 764 O TYR A 102 10.863 -20.877 31.385 1.00 30.22 O \\\\nATOM 765 CG TYR A 102 11.474 -20.073 35.861 1.00 30.22 C \\\\nATOM 766 CD1 TYR A 102 10.316 -20.404 36.597 1.00 30.22 C \\\\nATOM 767 CD2 TYR A 102 12.702 -19.909 36.528 1.00 30.22 C \\\\nATOM 768 CE1 TYR A 102 10.395 -20.584 37.993 1.00 30.22 C \\\\nATOM 769 CE2 TYR A 102 12.789 -20.106 37.919 1.00 30.22 C \\\\nATOM 770 OH TYR A 102 11.715 -20.639 39.995 1.00 30.22 O \\\\nATOM 771 CZ TYR A 102 11.635 -20.446 38.653 1.00 30.22 C \\\\nATOM 772 N SER A 103 9.636 -22.332 32.579 1.00 24.84 N \\\\nATOM 773 CA SER A 103 8.519 -22.529 31.672 1.00 24.84 C \\\\nATOM 774 C SER A 103 7.653 -21.269 31.646 1.00 24.84 C \\\\nATOM 775 CB SER A 103 7.727 -23.752 32.167 1.00 24.84 C \\\\nATOM 776 O SER A 103 6.948 -20.964 32.604 1.00 24.84 O \\\\nATOM 777 OG SER A 103 7.608 -23.765 33.584 1.00 24.84 O \\\\nATOM 778 N PHE A 104 7.684 -20.532 30.536 1.00 27.44 N \\\\nATOM 779 CA PHE A 104 6.739 -19.449 30.283 1.00 27.44 C \\\\nATOM 780 C PHE A 104 5.822 -19.864 29.138 1.00 27.44 C \\\\nATOM 781 CB PHE A 104 7.459 -18.110 30.061 1.00 27.44 C \\\\nATOM 782 O PHE A 104 6.258 -20.127 28.023 1.00 27.44 O \\\\nATOM 783 CG PHE A 104 6.856 -16.986 30.884 1.00 27.44 C \\\\nATOM 784 CD1 PHE A 104 5.896 -16.119 30.327 1.00 27.44 C \\\\nATOM 785 CD2 PHE A 104 7.246 -16.822 32.227 1.00 27.44 C \\\\nATOM 786 CE1 PHE A 104 5.346 -15.083 31.105 1.00 27.44 C \\\\nATOM 787 CE2 PHE A 104 6.696 -15.788 33.004 1.00 27.44 C \\\\nATOM 788 CZ PHE A 104 5.749 -14.915 32.443 1.00 27.44 C \\\\nATOM 789 N SER A 105 4.533 -19.978 29.442 1.00 27.30 N \\\\nATOM 790 CA SER A 105 3.481 -20.297 28.485 1.00 27.30 C \\\\nATOM 791 C SER A 105 3.463 -19.278 27.338 1.00 27.30 C \\\\nATOM 792 CB SER A 105 2.141 -20.303 29.231 1.00 27.30 C \\\\nATOM 793 O SER A 105 3.019 -18.142 27.521 1.00 27.30 O \\\\nATOM 794 OG SER A 105 1.982 -19.098 29.958 1.00 27.30 O \\\\nATOM 795 N GLU A 106 3.917 -19.692 26.156 1.00 25.42 N \\\\nATOM 796 CA GLU A 106 3.860 -18.921 24.914 1.00 25.42 C \\\\nATOM 797 C GLU A 106 2.403 -18.745 24.448 1.00 25.42 C \\\\nATOM 798 CB GLU A 106 4.702 -19.607 23.823 1.00 25.42 C \\\\nATOM 799 O GLU A 106 1.842 -19.550 23.706 1.00 25.42 O \\\\nATOM 800 CG GLU A 106 6.214 -19.418 24.009 1.00 25.42 C \\\\nATOM 801 CD GLU A 106 7.009 -20.112 22.892 1.00 25.42 C \\\\nATOM 802 OE1 GLU A 106 7.955 -19.480 22.375 1.00 25.42 O \\\\nATOM 803 OE2 GLU A 106 6.631 -21.253 22.542 1.00 25.42 O \\\\nATOM 804 N GLN A 107 1.765 -17.653 24.872 1.00 28.28 N \\\\nATOM 805 CA GLN A 107 0.642 -17.059 24.146 1.00 28.28 C \\\\nATOM 806 C GLN A 107 1.187 -15.917 23.290 1.00 28.28 C \\\\nATOM 807 CB GLN A 107 -0.488 -16.621 25.098 1.00 28.28 C \\\\nATOM 808 O GLN A 107 1.437 -14.817 23.774 1.00 28.28 O \\\\nATOM 809 CG GLN A 107 -1.620 -17.657 25.091 1.00 28.28 C \\\\nATOM 810 CD GLN A 107 -2.763 -17.340 26.051 1.00 28.28 C \\\\nATOM 811 NE2 GLN A 107 -3.799 -18.150 26.062 1.00 28.28 N \\\\nATOM 812 OE1 GLN A 107 -2.782 -16.380 26.803 1.00 28.28 O \\\\nATOM 813 N THR A 108 1.370 -16.198 22.003 1.00 28.45 N \\\\nATOM 814 CA THR A 108 1.763 -15.256 20.948 1.00 28.45 C \\\\nATOM 815 C THR A 108 0.865 -14.004 20.952 1.00 28.45 C \\\\nATOM 816 CB THR A 108 1.719 -15.973 19.575 1.00 28.45 C \\\\nATOM 817 O THR A 108 -0.259 -14.024 20.446 1.00 28.45 O \\\\nATOM 818 CG2 THR A 108 3.096 -16.467 19.142 1.00 28.45 C \\\\nATOM 819 OG1 THR A 108 0.905 -17.134 19.580 1.00 28.45 O \\\\nATOM 820 N ARG A 109 1.351 -12.899 21.542 1.00 34.15 N \\\\nATOM 821 CA ARG A 109 0.684 -11.581 21.578 1.00 34.15 C \\\\nATOM 822 C ARG A 109 0.880 -10.832 20.252 1.00 34.15 C \\\\nATOM 823 CB ARG A 109 1.190 -10.740 22.773 1.00 34.15 C \\\\nATOM 824 O ARG A 109 1.962 -10.830 19.675 1.00 34.15 O \\\\nATOM 825 CG ARG A 109 0.662 -11.219 24.138 1.00 34.15 C \\\\nATOM 826 CD ARG A 109 1.170 -10.320 25.277 1.00 34.15 C \\\\nATOM 827 NE ARG A 109 0.667 -10.750 26.600 1.00 34.15 N \\\\nATOM 828 NH1 ARG A 109 1.439 -8.933 27.757 1.00 34.15 N \\\\nATOM 829 NH2 ARG A 109 0.374 -10.503 28.864 1.00 34.15 N \\\\nATOM 830 CZ ARG A 109 0.826 -10.067 27.724 1.00 34.15 C \\\\nATOM 831 N SER A 110 -0.182 -10.209 19.747 1.00 40.36 N \\\\nATOM 832 CA SER A 110 -0.188 -9.347 18.556 1.00 40.36 C \\\\nATOM 833 C SER A 110 0.285 -7.932 18.902 1.00 40.36 C \\\\nATOM 834 CB SER A 110 -1.599 -9.285 17.940 1.00 40.36 C \\\\nATOM 835 O SER A 110 -0.391 -7.226 19.647 1.00 40.36 O \\\\nATOM 836 OG SER A 110 -2.593 -9.587 18.901 1.00 40.36 O \\\\nATOM 837 N LEU A 111 1.410 -7.521 18.308 1.00 46.85 N \\\\nATOM 838 CA LEU A 111 2.098 -6.232 18.510 1.00 46.85 C \\\\nATOM 839 C LEU A 111 1.354 -5.012 17.914 1.00 46.85 C \\\\nATOM 840 CB LEU A 111 3.521 -6.342 17.906 1.00 46.85 C \\\\nATOM 841 O LEU A 111 1.835 -3.891 18.007 1.00 46.85 O \\\\nATOM 842 CG LEU A 111 4.412 -7.471 18.467 1.00 46.85 C \\\\nATOM 843 CD1 LEU A 111 5.636 -7.678 17.575 1.00 46.85 C \\\\nATOM 844 CD2 LEU A 111 4.914 -7.198 19.881 1.00 46.85 C \\\\nATOM 845 N ASP A 112 0.196 -5.213 17.281 1.00 55.73 N \\\\nATOM 846 CA ASP A 112 -0.514 -4.217 16.466 1.00 55.73 C \\\\nATOM 847 C ASP A 112 -1.930 -3.883 16.980 1.00 55.73 C \\\\nATOM 848 CB ASP A 112 -0.510 -4.692 15.001 1.00 55.73 C \\\\nATOM 849 O ASP A 112 -2.784 -3.407 16.231 1.00 55.73 O \\\\nATOM 850 CG ASP A 112 -1.314 -5.975 14.740 1.00 55.73 C \\\\nATOM 851 OD1 ASP A 112 -1.678 -6.702 15.700 1.00 55.73 O \\\\nATOM 852 OD2 ASP A 112 -1.580 -6.257 13.548 1.00 55.73 O \\\\nATOM 853 N GLY A 113 -2.224 -4.171 18.253 1.00 59.81 N \\\\nATOM 854 CA GLY A 113 -3.535 -3.895 18.857 1.00 59.81 C \\\\nATOM 855 C GLY A 113 -4.675 -4.818 18.389 1.00 59.81 C \\\\nATOM 856 O GLY A 113 -5.836 -4.599 18.750 1.00 59.81 O \\\\nATOM 857 N ARG A 114 -4.391 -5.854 17.582 1.00 63.47 N \\\\nATOM 858 CA ARG A 114 -5.409 -6.800 17.093 1.00 63.47 C \\\\nATOM 859 C ARG A 114 -5.798 -7.824 18.152 1.00 63.47 C \\\\nATOM 860 CB ARG A 114 -4.942 -7.495 15.809 1.00 63.47 C \\\\nATOM 861 O ARG A 114 -4.953 -8.455 18.775 1.00 63.47 O \\\\nATOM 862 CG ARG A 114 -4.841 -6.507 14.643 1.00 63.47 C \\\\nATOM 863 CD ARG A 114 -4.440 -7.238 13.362 1.00 63.47 C \\\\nATOM 864 NE ARG A 114 -4.171 -6.273 12.286 1.00 63.47 N \\\\nATOM 865 NH1 ARG A 114 -3.462 -7.784 10.712 1.00 63.47 N \\\\nATOM 866 NH2 ARG A 114 -3.261 -5.593 10.321 1.00 63.47 N \\\\nATOM 867 CZ ARG A 114 -3.634 -6.555 11.116 1.00 63.47 C \\\\nATOM 868 N LEU A 115 -7.096 -8.079 18.277 1.00 74.63 N \\\\nATOM 869 CA LEU A 115 -7.659 -9.174 19.058 1.00 74.63 C \\\\nATOM 870 C LEU A 115 -7.690 -10.461 18.228 1.00 74.63 C \\\\nATOM 871 CB LEU A 115 -9.063 -8.754 19.520 1.00 74.63 C \\\\nATOM 872 O LEU A 115 -8.206 -10.474 17.111 1.00 74.63 O \\\\nATOM 873 CG LEU A 115 -9.828 -9.795 20.351 1.00 74.63 C \\\\nATOM 874 CD1 LEU A 115 -9.130 -10.049 21.690 1.00 74.63 C \\\\nATOM 875 CD2 LEU A 115 -11.243 -9.286 20.637 1.00 74.63 C \\\\nATOM 876 N GLN A 116 -7.198 -11.560 18.799 1.00 75.91 N \\\\nATOM 877 CA GLN A 116 -7.332 -12.890 18.211 1.00 75.91 C \\\\nATOM 878 C GLN A 116 -8.573 -13.606 18.758 1.00 75.91 C \\\\nATOM 879 CB GLN A 116 -6.034 -13.680 18.419 1.00 75.91 C \\\\nATOM 880 O GLN A 116 -8.695 -13.840 19.961 1.00 75.91 O \\\\nATOM 881 CG GLN A 116 -6.031 -15.028 17.672 1.00 75.91 C \\\\nATOM 882 CD GLN A 116 -4.640 -15.661 17.623 1.00 75.91 C \\\\nATOM 883 NE2 GLN A 116 -4.521 -16.957 17.437 1.00 75.91 N \\\\nATOM 884 OE1 GLN A 116 -3.625 -14.996 17.701 1.00 75.91 O \\\\nATOM 885 N VAL A 117 -9.483 -13.994 17.865 1.00 72.04 N \\\\nATOM 886 CA VAL A 117 -10.655 -14.827 18.167 1.00 72.04 C \\\\nATOM 887 C VAL A 117 -10.622 -16.049 17.256 1.00 72.04 C \\\\nATOM 888 CB VAL A 117 -11.978 -14.051 17.996 1.00 72.04 C \\\\nATOM 889 O VAL A 117 -10.773 -15.928 16.043 1.00 72.04 O \\\\nATOM 890 CG1 VAL A 117 -13.165 -14.936 18.402 1.00 72.04 C \\\\nATOM 891 CG2 VAL A 117 -12.019 -12.777 18.849 1.00 72.04 C \\\\nATOM 892 N SER A 118 -10.434 -17.240 17.837 1.00 68.99 N \\\\nATOM 893 CA SER A 118 -10.448 -18.525 17.114 1.00 68.99 C \\\\nATOM 894 C SER A 118 -9.568 -18.523 15.851 1.00 68.99 C \\\\nATOM 895 CB SER A 118 -11.902 -18.925 16.820 1.00 68.99 C \\\\nATOM 896 O SER A 118 -10.045 -18.857 14.771 1.00 68.99 O \\\\nATOM 897 OG SER A 118 -12.005 -20.289 16.448 1.00 68.99 O \\\\nATOM 898 N HIS A 119 -8.298 -18.123 15.997 1.00 68.93 N \\\\nATOM 899 CA HIS A 119 -7.280 -17.992 14.933 1.00 68.93 C \\\\nATOM 900 C HIS A 119 -7.458 -16.828 13.945 1.00 68.93 C \\\\nATOM 901 CB HIS A 119 -7.038 -19.332 14.213 1.00 68.93 C \\\\nATOM 902 O HIS A 119 -6.550 -16.568 13.163 1.00 68.93 O \\\\nATOM 903 CG HIS A 119 -6.783 -20.471 15.161 1.00 68.93 C \\\\nATOM 904 CD2 HIS A 119 -7.722 -21.318 15.683 1.00 68.93 C \\\\nATOM 905 ND1 HIS A 119 -5.566 -20.833 15.692 1.00 68.93 N \\\\nATOM 906 CE1 HIS A 119 -5.772 -21.870 16.522 1.00 68.93 C \\\\nATOM 907 NE2 HIS A 119 -7.079 -22.174 16.576 1.00 68.93 N \\\\nATOM 908 N ARG A 120 -8.551 -16.058 14.018 1.00 73.52 N \\\\nATOM 909 CA ARG A 120 -8.704 -14.816 13.243 1.00 73.52 C \\\\nATOM 910 C ARG A 120 -8.238 -13.621 14.072 1.00 73.52 C \\\\nATOM 911 CB ARG A 120 -10.150 -14.654 12.750 1.00 73.52 C \\\\nATOM 912 O ARG A 120 -8.711 -13.441 15.194 1.00 73.52 O \\\\nATOM 913 CG ARG A 120 -10.598 -15.814 11.841 1.00 73.52 C \\\\nATOM 914 CD ARG A 120 -11.986 -15.551 11.237 1.00 73.52 C \\\\nATOM 915 NE ARG A 120 -12.393 -16.616 10.296 1.00 73.52 N \\\\nATOM 916 NH1 ARG A 120 -14.515 -15.835 9.841 1.00 73.52 N \\\\nATOM 917 NH2 ARG A 120 -13.766 -17.643 8.785 1.00 73.52 N \\\\nATOM 918 CZ ARG A 120 -13.550 -16.692 9.650 1.00 73.52 C \\\\nATOM 919 N LYS A 121 -7.316 -12.819 13.535 1.00 76.82 N \\\\nATOM 920 CA LYS A 121 -6.859 -11.555 14.138 1.00 76.82 C \\\\nATOM 921 C LYS A 121 -7.628 -10.391 13.514 1.00 76.82 C \\\\nATOM 922 CB LYS A 121 -5.338 -11.376 13.963 1.00 76.82 C \\\\nATOM 923 O LYS A 121 -7.679 -10.288 12.295 1.00 76.82 O \\\\nATOM 924 CG LYS A 121 -4.515 -12.378 14.792 1.00 76.82 C \\\\nATOM 925 CD LYS A 121 -3.003 -12.124 14.659 1.00 76.82 C \\\\nATOM 926 CE LYS A 121 -2.218 -13.100 15.552 1.00 76.82 C \\\\nATOM 927 NZ LYS A 121 -0.748 -12.887 15.486 1.00 76.82 N \\\\nATOM 928 N GLY A 122 -8.187 -9.507 14.332 1.00 81.47 N \\\\nATOM 929 CA GLY A 122 -8.886 -8.310 13.863 1.00 81.47 C \\\\nATOM 930 C GLY A 122 -8.894 -7.214 14.919 1.00 81.47 C \\\\nATOM 931 O GLY A 122 -8.692 -7.476 16.103 1.00 81.47 O \\\\nATOM 932 N LEU A 123 -9.103 -5.968 14.505 1.00 87.81 N \\\\nATOM 933 CA LEU A 123 -9.176 -4.849 15.442 1.00 87.81 C \\\\nATOM 934 C LEU A 123 -10.486 -4.927 16.247 1.00 87.81 C \\\\nATOM 935 CB LEU A 123 -9.035 -3.529 14.676 1.00 87.81 C \\\\nATOM 936 O LEU A 123 -11.540 -5.149 15.648 1.00 87.81 O \\\\nATOM 937 CG LEU A 123 -7.629 -3.315 14.083 1.00 87.81 C \\\\nATOM 938 CD1 LEU A 123 -7.642 -2.128 13.128 1.00 87.81 C \\\\nATOM 939 CD2 LEU A 123 -6.585 -3.067 15.172 1.00 87.81 C \\\\nATOM 940 N PRO A 124 -10.460 -4.748 17.583 1.00 91.18 N \\\\nATOM 941 CA PRO A 124 -11.645 -4.955 18.413 1.00 91.18 C \\\\nATOM 942 C PRO A 124 -12.867 -4.149 17.976 1.00 91.18 C \\\\nATOM 943 CB PRO A 124 -11.227 -4.558 19.825 1.00 91.18 C \\\\nATOM 944 O PRO A 124 -13.944 -4.708 17.804 1.00 91.18 O \\\\nATOM 945 CG PRO A 124 -9.724 -4.812 19.848 1.00 91.18 C \\\\nATOM 946 CD PRO A 124 -9.285 -4.515 18.417 1.00 91.18 C \\\\nATOM 947 N HIS A 125 -12.693 -2.846 17.760 1.00 92.35 N \\\\nATOM 948 CA HIS A 125 -13.778 -1.954 17.364 1.00 92.35 C \\\\nATOM 949 C HIS A 125 -14.386 -2.352 16.009 1.00 92.35 C \\\\nATOM 950 CB HIS A 125 -13.265 -0.512 17.371 1.00 92.35 C \\\\nATOM 951 O HIS A 125 -15.605 -2.341 15.875 1.00 92.35 O \\\\nATOM 952 CG HIS A 125 -12.171 -0.245 16.372 1.00 92.35 C \\\\nATOM 953 CD2 HIS A 125 -12.325 0.383 15.167 1.00 92.35 C \\\\nATOM 954 ND1 HIS A 125 -10.841 -0.590 16.492 1.00 92.35 N \\\\nATOM 955 CE1 HIS A 125 -10.216 -0.192 15.373 1.00 92.35 C \\\\nATOM 956 NE2 HIS A 125 -11.081 0.391 14.540 1.00 92.35 N \\\\nATOM 957 N VAL A 126 -13.568 -2.806 15.049 1.00 92.28 N \\\\nATOM 958 CA VAL A 126 -14.039 -3.320 13.750 1.00 92.28 C \\\\nATOM 959 C VAL A 126 -14.865 -4.590 13.928 1.00 92.28 C \\\\nATOM 960 CB VAL A 126 -12.871 -3.598 12.784 1.00 92.28 C \\\\nATOM 961 O VAL A 126 -15.959 -4.678 13.385 1.00 92.28 O \\\\nATOM 962 CG1 VAL A 126 -13.341 -4.074 11.404 1.00 92.28 C \\\\nATOM 963 CG2 VAL A 126 -12.036 -2.341 12.566 1.00 92.28 C \\\\nATOM 964 N ILE A 127 -14.385 -5.556 14.724 1.00 92.20 N \\\\nATOM 965 CA ILE A 127 -15.093 -6.826 14.975 1.00 92.20 C \\\\nATOM 966 C ILE A 127 -16.507 -6.566 15.506 1.00 92.20 C \\\\nATOM 967 CB ILE A 127 -14.283 -7.710 15.959 1.00 92.20 C \\\\nATOM 968 O ILE A 127 -17.475 -7.159 15.032 1.00 92.20 O \\\\nATOM 969 CG1 ILE A 127 -13.002 -8.244 15.276 1.00 92.20 C \\\\nATOM 970 CG2 ILE A 127 -15.144 -8.865 16.517 1.00 92.20 C \\\\nATOM 971 CD1 ILE A 127 -11.991 -8.869 16.249 1.00 92.20 C \\\\nATOM 972 N TYR A 128 -16.629 -5.678 16.490 1.00 94.45 N \\\\nATOM 973 CA TYR A 128 -17.897 -5.428 17.169 1.00 94.45 C \\\\nATOM 974 C TYR A 128 -18.826 -4.489 16.387 1.00 94.45 C \\\\nATOM 975 CB TYR A 128 -17.579 -4.936 18.580 1.00 94.45 C \\\\nATOM 976 O TYR A 128 -20.036 -4.712 16.376 1.00 94.45 O \\\\nATOM 977 CG TYR A 128 -16.888 -5.987 19.446 1.00 94.45 C \\\\nATOM 978 CD1 TYR A 128 -17.417 -7.286 19.612 1.00 94.45 C \\\\nATOM 979 CD2 TYR A 128 -15.647 -5.676 20.023 1.00 94.45 C \\\\nATOM 980 CE1 TYR A 128 -16.688 -8.263 20.326 1.00 94.45 C \\\\nATOM 981 CE2 TYR A 128 -14.923 -6.631 20.751 1.00 94.45 C \\\\nATOM 982 OH TYR A 128 -14.702 -8.853 21.570 1.00 94.45 O \\\\nATOM 983 CZ TYR A 128 -15.439 -7.932 20.894 1.00 94.45 C \\\\nATOM 984 N CYS A 129 -18.287 -3.513 15.647 1.00 94.84 N \\\\nATOM 985 CA CYS A 129 -19.075 -2.754 14.671 1.00 94.84 C \\\\nATOM 986 C CYS A 129 -19.608 -3.661 13.555 1.00 94.84 C \\\\nATOM 987 CB CYS A 129 -18.240 -1.615 14.078 1.00 94.84 C \\\\nATOM 988 O CYS A 129 -20.777 -3.539 13.185 1.00 94.84 O \\\\nATOM 989 SG CYS A 129 -17.923 -0.349 15.334 1.00 94.84 S \\\\nATOM 990 N ARG A 130 -18.794 -4.612 13.071 1.00 93.45 N \\\\nATOM 991 CA ARG A 130 -19.218 -5.591 12.064 1.00 93.45 C \\\\nATOM 992 C ARG A 130 -20.382 -6.446 12.561 1.00 93.45 C \\\\nATOM 993 CB ARG A 130 -18.024 -6.446 11.593 1.00 93.45 C \\\\nATOM 994 O ARG A 130 -21.346 -6.669 11.841 1.00 93.45 O \\\\nATOM 995 CG ARG A 130 -18.402 -7.345 10.401 1.00 93.45 C \\\\nATOM 996 CD ARG A 130 -17.297 -8.325 9.987 1.00 93.45 C \\\\nATOM 997 NE ARG A 130 -16.140 -7.643 9.388 1.00 93.45 N \\\\nATOM 998 NH1 ARG A 130 -14.894 -9.481 8.823 1.00 93.45 N \\\\nATOM 999 NH2 ARG A 130 -14.164 -7.456 8.280 1.00 93.45 N \\\\nATOM 1000 CZ ARG A 130 -15.073 -8.194 8.841 1.00 93.45 C \\\\nATOM 1001 N LEU A 131 -20.314 -6.886 13.817 1.00 93.42 N \\\\nATOM 1002 CA LEU A 131 -21.314 -7.774 14.406 1.00 93.42 C \\\\nATOM 1003 C LEU A 131 -22.680 -7.088 14.596 1.00 93.42 C \\\\nATOM 1004 CB LEU A 131 -20.719 -8.351 15.707 1.00 93.42 C \\\\nATOM 1005 O LEU A 131 -23.709 -7.687 14.289 1.00 93.42 O \\\\nATOM 1006 CG LEU A 131 -21.370 -9.671 16.157 1.00 93.42 C \\\\nATOM 1007 CD1 LEU A 131 -20.361 -10.540 16.910 1.00 93.42 C \\\\nATOM 1008 CD2 LEU A 131 -22.557 -9.466 17.093 1.00 93.42 C \\\\nATOM 1009 N TRP A 132 -22.702 -5.844 15.089 1.00 95.06 N \\\\nATOM 1010 CA TRP A 132 -23.948 -5.172 15.499 1.00 95.06 C \\\\nATOM 1011 C TRP A 132 -24.456 -4.081 14.555 1.00 95.06 C \\\\nATOM 1012 CB TRP A 132 -23.787 -4.636 16.926 1.00 95.06 C \\\\nATOM 1013 O TRP A 132 -25.597 -3.646 14.709 1.00 95.06 O \\\\nATOM 1014 CG TRP A 132 -23.688 -5.707 17.963 1.00 95.06 C \\\\nATOM 1015 CD1 TRP A 132 -24.630 -6.650 18.186 1.00 95.06 C \\\\nATOM 1016 CD2 TRP A 132 -22.612 -5.982 18.908 1.00 95.06 C \\\\nATOM 1017 CE2 TRP A 132 -22.962 -7.158 19.640 1.00 95.06 C \\\\nATOM 1018 CE3 TRP A 132 -21.388 -5.357 19.239 1.00 95.06 C \\\\nATOM 1019 NE1 TRP A 132 -24.209 -7.512 19.174 1.00 95.06 N \\\\nATOM 1020 CH2 TRP A 132 -20.887 -7.109 20.860 1.00 95.06 C \\\\nATOM 1021 CZ2 TRP A 132 -22.104 -7.738 20.579 1.00 95.06 C \\\\nATOM 1022 CZ3 TRP A 132 -20.553 -5.900 20.234 1.00 95.06 C \\\\nATOM 1023 N ARG A 133 -23.656 -3.624 13.585 1.00 93.80 N \\\\nATOM 1024 CA ARG A 133 -24.057 -2.527 12.688 1.00 93.80 C \\\\nATOM 1025 C ARG A 133 -23.903 -2.858 11.214 1.00 93.80 C \\\\nATOM 1026 CB ARG A 133 -23.327 -1.232 13.054 1.00 93.80 C \\\\nATOM 1027 O ARG A 133 -24.900 -2.799 10.502 1.00 93.80 O \\\\nATOM 1028 CG ARG A 133 -23.740 -0.768 14.456 1.00 93.80 C \\\\nATOM 1029 CD ARG A 133 -23.208 0.630 14.740 1.00 93.80 C \\\\nATOM 1030 NE ARG A 133 -23.885 1.638 13.906 1.00 93.80 N \\\\nATOM 1031 NH1 ARG A 133 -22.534 3.330 14.523 1.00 93.80 N \\\\nATOM 1032 NH2 ARG A 133 -24.172 3.753 13.078 1.00 93.80 N \\\\nATOM 1033 CZ ARG A 133 -23.534 2.902 13.829 1.00 93.80 C \\\\nATOM 1034 N TRP A 134 -22.698 -3.219 10.781 1.00 92.86 N \\\\nATOM 1035 CA TRP A 134 -22.355 -3.332 9.359 1.00 92.86 C \\\\nATOM 1036 C TRP A 134 -21.638 -4.658 9.065 1.00 92.86 C \\\\nATOM 1037 CB TRP A 134 -21.502 -2.122 8.961 1.00 92.86 C \\\\nATOM 1038 O TRP A 134 -20.412 -4.713 9.159 1.00 92.86 O \\\\nATOM 1039 CG TRP A 134 -22.128 -0.786 9.203 1.00 92.86 C \\\\nATOM 1040 CD1 TRP A 134 -23.200 -0.283 8.552 1.00 92.86 C \\\\nATOM 1041 CD2 TRP A 134 -21.717 0.237 10.155 1.00 92.86 C \\\\nATOM 1042 CE2 TRP A 134 -22.578 1.364 10.001 1.00 92.86 C \\\\nATOM 1043 CE3 TRP A 134 -20.693 0.326 11.122 1.00 92.86 C \\\\nATOM 1044 NE1 TRP A 134 -23.466 0.992 9.014 1.00 92.86 N \\\\nATOM 1045 CH2 TRP A 134 -21.345 2.608 11.666 1.00 92.86 C \\\\nATOM 1046 CZ2 TRP A 134 -22.397 2.543 10.734 1.00 92.86 C \\\\nATOM 1047 CZ3 TRP A 134 -20.518 1.495 11.882 1.00 92.86 C \\\\nATOM 1048 N PRO A 135 -22.366 -5.742 8.736 1.00 90.70 N \\\\nATOM 1049 CA PRO A 135 -21.776 -7.058 8.453 1.00 90.70 C \\\\nATOM 1050 C PRO A 135 -20.717 -7.044 7.344 1.00 90.70 C \\\\nATOM 1051 CB PRO A 135 -22.955 -7.949 8.049 1.00 90.70 C \\\\nATOM 1052 O PRO A 135 -19.789 -7.847 7.363 1.00 90.70 O \\\\nATOM 1053 CG PRO A 135 -24.131 -7.309 8.777 1.00 90.70 C \\\\nATOM 1054 CD PRO A 135 -23.817 -5.820 8.695 1.00 90.70 C \\\\nATOM 1055 N ASP A 136 -20.846 -6.097 6.421 1.00 86.88 N \\\\nATOM 1056 CA ASP A 136 -19.995 -5.838 5.263 1.00 86.88 C \\\\nATOM 1057 C ASP A 136 -18.812 -4.895 5.560 1.00 86.88 C \\\\nATOM 1058 CB ASP A 136 -20.896 -5.265 4.158 1.00 86.88 C \\\\nATOM 1059 O ASP A 136 -18.151 -4.428 4.642 1.00 86.88 O \\\\nATOM 1060 CG ASP A 136 -21.458 -3.882 4.516 1.00 86.88 C \\\\nATOM 1061 OD1 ASP A 136 -21.929 -3.679 5.663 1.00 86.88 O \\\\nATOM 1062 OD2 ASP A 136 -21.416 -2.979 3.656 1.00 86.88 O \\\\nATOM 1063 N LEU A 137 -18.537 -4.569 6.825 1.00 87.97 N \\\\nATOM 1064 CA LEU A 137 -17.401 -3.726 7.204 1.00 87.97 C \\\\nATOM 1065 C LEU A 137 -16.083 -4.498 7.075 1.00 87.97 C \\\\nATOM 1066 CB LEU A 137 -17.626 -3.275 8.656 1.00 87.97 C \\\\nATOM 1067 O LEU A 137 -15.883 -5.449 7.826 1.00 87.97 O \\\\nATOM 1068 CG LEU A 137 -16.543 -2.322 9.169 1.00 87.97 C \\\\nATOM 1069 CD1 LEU A 137 -16.738 -0.932 8.577 1.00 87.97 C \\\\nATOM 1070 CD2 LEU A 137 -16.615 -2.224 10.690 1.00 87.97 C \\\\nATOM 1071 N HIS A 138 -15.128 -4.080 6.248 1.00 80.97 N \\\\nATOM 1072 CA HIS A 138 -13.871 -4.808 6.009 1.00 80.97 C \\\\nATOM 1073 C HIS A 138 -12.685 -4.237 6.790 1.00 80.97 C \\\\nATOM 1074 CB HIS A 138 -13.578 -4.858 4.507 1.00 80.97 C \\\\nATOM 1075 O HIS A 138 -11.864 -4.998 7.313 1.00 80.97 O \\\\nATOM 1076 CG HIS A 138 -14.632 -5.637 3.769 1.00 80.97 C \\\\nATOM 1077 CD2 HIS A 138 -14.644 -6.985 3.527 1.00 80.97 C \\\\nATOM 1078 ND1 HIS A 138 -15.826 -5.137 3.311 1.00 80.97 N \\\\nATOM 1079 CE1 HIS A 138 -16.550 -6.158 2.830 1.00 80.97 C \\\\nATOM 1080 NE2 HIS A 138 -15.882 -7.311 2.973 1.00 80.97 N \\\\nATOM 1081 N SER A 139 -12.614 -2.912 6.917 1.00 83.17 N \\\\nATOM 1082 CA SER A 139 -11.460 -2.200 7.465 1.00 83.17 C \\\\nATOM 1083 C SER A 139 -11.837 -1.201 8.559 1.00 83.17 C \\\\nATOM 1084 CB SER A 139 -10.727 -1.495 6.323 1.00 83.17 C \\\\nATOM 1085 O SER A 139 -12.946 -0.681 8.615 1.00 83.17 O \\\\nATOM 1086 OG SER A 139 -9.516 -0.929 6.795 1.00 83.17 O \\\\nATOM 1087 N HIS A 140 -10.874 -0.881 9.425 1.00 86.11 N \\\\nATOM 1088 CA HIS A 140 -11.016 0.216 10.386 1.00 86.11 C \\\\nATOM 1089 C HIS A 140 -11.071 1.593 9.723 1.00 86.11 C \\\\nATOM 1090 CB HIS A 140 -9.873 0.183 11.399 1.00 86.11 C \\\\nATOM 1091 O HIS A 140 -11.634 2.512 10.302 1.00 86.11 O \\\\nATOM 1092 CG HIS A 140 -8.528 0.596 10.861 1.00 86.11 C \\\\nATOM 1093 CD2 HIS A 140 -7.865 1.738 11.215 1.00 86.11 C \\\\nATOM 1094 ND1 HIS A 140 -7.736 -0.065 9.944 1.00 86.11 N \\\\nATOM 1095 CE1 HIS A 140 -6.614 0.656 9.776 1.00 86.11 C \\\\nATOM 1096 NE2 HIS A 140 -6.642 1.752 10.548 1.00 86.11 N \\\\nATOM 1097 N HIS A 141 -10.518 1.731 8.516 1.00 83.95 N \\\\nATOM 1098 CA HIS A 141 -10.558 2.982 7.763 1.00 83.95 C \\\\nATOM 1099 C HIS A 141 -11.983 3.357 7.319 1.00 83.95 C \\\\nATOM 1100 CB HIS A 141 -9.626 2.852 6.557 1.00 83.95 C \\\\nATOM 1101 O HIS A 141 -12.252 4.526 7.079 1.00 83.95 O \\\\nATOM 1102 CG HIS A 141 -8.176 2.638 6.875 1.00 83.95 C \\\\nATOM 1103 CD2 HIS A 141 -7.388 1.619 6.415 1.00 83.95 C \\\\nATOM 1104 ND1 HIS A 141 -7.370 3.480 7.600 1.00 83.95 N \\\\nATOM 1105 CE1 HIS A 141 -6.130 2.966 7.596 1.00 83.95 C \\\\nATOM 1106 NE2 HIS A 141 -6.101 1.811 6.913 1.00 83.95 N \\\\nATOM 1107 N GLU A 142 -12.907 2.391 7.256 1.00 89.04 N \\\\nATOM 1108 CA GLU A 142 -14.330 2.634 6.979 1.00 89.04 C \\\\nATOM 1109 C GLU A 142 -15.081 3.182 8.203 1.00 89.04 C \\\\nATOM 1110 CB GLU A 142 -14.996 1.327 6.533 1.00 89.04 C \\\\nATOM 1111 O GLU A 142 -16.275 3.461 8.114 1.00 89.04 O \\\\nATOM 1112 CG GLU A 142 -14.534 0.776 5.184 1.00 89.04 C \\\\nATOM 1113 CD GLU A 142 -15.197 -0.587 4.961 1.00 89.04 C \\\\nATOM 1114 OE1 GLU A 142 -14.500 -1.600 5.214 1.00 89.04 O \\\\nATOM 1115 OE2 GLU A 142 -16.417 -0.627 4.667 1.00 89.04 O \\\\nATOM 1116 N LEU A 143 -14.414 3.318 9.354 1.00 92.20 N \\\\nATOM 1117 CA LEU A 143 -14.996 3.828 10.589 1.00 92.20 C \\\\nATOM 1118 C LEU A 143 -14.329 5.133 11.019 1.00 92.20 C \\\\nATOM 1119 CB LEU A 143 -14.878 2.787 11.713 1.00 92.20 C \\\\nATOM 1120 O LEU A 143 -13.109 5.228 11.135 1.00 92.20 O \\\\nATOM 1121 CG LEU A 143 -15.634 1.470 11.494 1.00 92.20 C \\\\nATOM 1122 CD1 LEU A 143 -15.407 0.591 12.728 1.00 92.20 C \\\\nATOM 1123 CD2 LEU A 143 -17.138 1.678 11.311 1.00 92.20 C \\\\nATOM 1124 N LYS A 144 -15.152 6.111 11.389 1.00 92.19 N \\\\nATOM 1125 CA LYS A 144 -14.738 7.329 12.086 1.00 92.19 C \\\\nATOM 1126 C LYS A 144 -15.326 7.324 13.491 1.00 92.19 C \\\\nATOM 1127 CB LYS A 144 -15.184 8.540 11.257 1.00 92.19 C \\\\nATOM 1128 O LYS A 144 -16.518 7.089 13.653 1.00 92.19 O \\\\nATOM 1129 CG LYS A 144 -14.603 9.851 11.803 1.00 92.19 C \\\\nATOM 1130 CD LYS A 144 -15.084 11.048 10.975 1.00 92.19 C \\\\nATOM 1131 CE LYS A 144 -14.518 12.350 11.557 1.00 92.19 C \\\\nATOM 1132 NZ LYS A 144 -15.052 13.546 10.857 1.00 92.19 N \\\\nATOM 1133 N ALA A 145 -14.516 7.560 14.518 1.00 93.48 N \\\\nATOM 1134 CA ALA A 145 -15.049 7.713 15.868 1.00 93.48 C \\\\nATOM 1135 C ALA A 145 -15.831 9.030 16.001 1.00 93.48 C \\\\nATOM 1136 CB ALA A 145 -13.917 7.608 16.883 1.00 93.48 C \\\\nATOM 1137 O ALA A 145 -15.466 10.033 15.386 1.00 93.48 O \\\\nATOM 1138 N ILE A 146 -16.892 9.026 16.808 1.00 93.88 N \\\\nATOM 1139 CA ILE A 146 -17.597 10.257 17.182 1.00 93.88 C \\\\nATOM 1140 C ILE A 146 -16.704 11.122 18.078 1.00 93.88 C \\\\nATOM 1141 CB ILE A 146 -18.961 9.968 17.849 1.00 93.88 C \\\\nATOM 1142 O ILE A 146 -15.877 10.599 18.826 1.00 93.88 O \\\\nATOM 1143 CG1 ILE A 146 -18.805 9.282 19.226 1.00 93.88 C \\\\nATOM 1144 CG2 ILE A 146 -19.859 9.172 16.883 1.00 93.88 C \\\\nATOM 1145 CD1 ILE A 146 -20.121 9.053 19.971 1.00 93.88 C \\\\nATOM 1146 N GLU A 147 -16.913 12.435 18.052 1.00 91.33 N \\\\nATOM 1147 CA GLU A 147 -16.085 13.403 18.790 1.00 91.33 C \\\\nATOM 1148 C GLU A 147 -16.111 13.177 20.310 1.00 91.33 C \\\\nATOM 1149 CB GLU A 147 -16.553 14.823 18.439 1.00 91.33 C \\\\nATOM 1150 O GLU A 147 -15.098 13.340 20.983 1.00 91.33 O \\\\nATOM 1151 CG GLU A 147 -16.354 15.112 16.940 1.00 91.33 C \\\\nATOM 1152 CD GLU A 147 -16.770 16.525 16.513 1.00 91.33 C \\\\nATOM 1153 OE1 GLU A 147 -16.509 16.831 15.328 1.00 91.33 O \\\\nATOM 1154 OE2 GLU A 147 -17.365 17.248 17.340 1.00 91.33 O \\\\nATOM 1155 N ASN A 148 -17.234 12.684 20.840 1.00 91.34 N \\\\nATOM 1156 CA ASN A 148 -17.417 12.424 22.271 1.00 91.34 C \\\\nATOM 1157 C ASN A 148 -16.788 11.098 22.750 1.00 91.34 C \\\\nATOM 1158 CB ASN A 148 -18.923 12.499 22.595 1.00 91.34 C \\\\nATOM 1159 O ASN A 148 -16.949 10.719 23.912 1.00 91.34 O \\\\nATOM 1160 CG ASN A 148 -19.535 13.868 22.344 1.00 91.34 C \\\\nATOM 1161 ND2 ASN A 148 -20.838 13.988 22.425 1.00 91.34 N \\\\nATOM 1162 OD1 ASN A 148 -18.871 14.846 22.065 1.00 91.34 O \\\\nATOM 1163 N CYS A 149 -16.116 10.339 21.876 1.00 93.59 N \\\\nATOM 1164 CA CYS A 149 -15.512 9.064 22.252 1.00 93.59 C \\\\nATOM 1165 C CYS A 149 -14.118 9.261 22.868 1.00 93.59 C \\\\nATOM 1166 CB CYS A 149 -15.482 8.123 21.045 1.00 93.59 C \\\\nATOM 1167 O CYS A 149 -13.117 9.411 22.171 1.00 93.59 O \\\\nATOM 1168 SG CYS A 149 -15.018 6.462 21.626 1.00 93.59 S \\\\nATOM 1169 N GLU A 150 -14.029 9.163 24.194 1.00 93.72 N \\\\nATOM 1170 CA GLU A 150 -12.774 9.344 24.940 1.00 93.72 C \\\\nATOM 1171 C GLU A 150 -11.730 8.236 24.711 1.00 93.72 C \\\\nATOM 1172 CB GLU A 150 -13.086 9.387 26.438 1.00 93.72 C \\\\nATOM 1173 O GLU A 150 -10.553 8.426 25.023 1.00 93.72 O \\\\nATOM 1174 CG GLU A 150 -13.967 10.569 26.859 1.00 93.72 C \\\\nATOM 1175 CD GLU A 150 -14.248 10.552 28.369 1.00 93.72 C \\\\nATOM 1176 OE1 GLU A 150 -14.711 11.592 28.878 1.00 93.72 O \\\\nATOM 1177 OE2 GLU A 150 -14.031 9.488 29.003 1.00 93.72 O \\\\nATOM 1178 N TYR A 151 -12.142 7.075 24.195 1.00 93.47 N \\\\nATOM 1179 CA TYR A 151 -11.293 5.890 23.995 1.00 93.47 C \\\\nATOM 1180 C TYR A 151 -11.321 5.414 22.538 1.00 93.47 C \\\\nATOM 1181 CB TYR A 151 -11.669 4.785 24.992 1.00 93.47 C \\\\nATOM 1182 O TYR A 151 -11.233 4.219 22.254 1.00 93.47 O \\\\nATOM 1183 CG TYR A 151 -11.472 5.166 26.442 1.00 93.47 C \\\\nATOM 1184 CD1 TYR A 151 -10.273 4.836 27.103 1.00 93.47 C \\\\nATOM 1185 CD2 TYR A 151 -12.494 5.844 27.131 1.00 93.47 C \\\\nATOM 1186 CE1 TYR A 151 -10.105 5.180 28.459 1.00 93.47 C \\\\nATOM 1187 CE2 TYR A 151 -12.315 6.225 28.472 1.00 93.47 C \\\\nATOM 1188 OH TYR A 151 -10.938 6.273 30.427 1.00 93.47 O \\\\nATOM 1189 CZ TYR A 151 -11.120 5.884 29.140 1.00 93.47 C \\\\nATOM 1190 N ALA A 152 -11.501 6.342 21.600 1.00 91.45 N \\\\nATOM 1191 CA ALA A 152 -11.484 6.039 20.179 1.00 91.45 C \\\\nATOM 1192 C ALA A 152 -10.160 5.383 19.747 1.00 91.45 C \\\\nATOM 1193 CB ALA A 152 -11.749 7.336 19.422 1.00 91.45 C \\\\nATOM 1194 O ALA A 152 -9.087 5.708 20.256 1.00 91.45 O \\\\nATOM 1195 N PHE A 153 -10.225 4.463 18.780 1.00 88.26 N \\\\nATOM 1196 CA PHE A 153 -9.057 3.704 18.316 1.00 88.26 C \\\\nATOM 1197 C PHE A 153 -7.881 4.587 17.858 1.00 88.26 C \\\\nATOM 1198 CB PHE A 153 -9.508 2.782 17.176 1.00 88.26 C \\\\nATOM 1199 O PHE A 153 -6.724 4.286 18.149 1.00 88.26 O \\\\nATOM 1200 CG PHE A 153 -8.366 2.037 16.511 1.00 88.26 C \\\\nATOM 1201 CD1 PHE A 153 -7.961 2.377 15.205 1.00 88.26 C \\\\nATOM 1202 CD2 PHE A 153 -7.685 1.024 17.212 1.00 88.26 C \\\\nATOM 1203 CE1 PHE A 153 -6.883 1.703 14.605 1.00 88.26 C \\\\nATOM 1204 CE2 PHE A 153 -6.613 0.347 16.607 1.00 88.26 C \\\\nATOM 1205 CZ PHE A 153 -6.213 0.684 15.303 1.00 88.26 C \\\\nATOM 1206 N ASN A 154 -8.167 5.704 17.189 1.00 84.98 N \\\\nATOM 1207 CA ASN A 154 -7.164 6.657 16.710 1.00 84.98 C \\\\nATOM 1208 C ASN A 154 -6.425 7.402 17.838 1.00 84.98 C \\\\nATOM 1209 CB ASN A 154 -7.825 7.648 15.730 1.00 84.98 C \\\\nATOM 1210 O ASN A 154 -5.341 7.921 17.585 1.00 84.98 O \\\\nATOM 1211 CG ASN A 154 -8.927 8.482 16.366 1.00 84.98 C \\\\nATOM 1212 ND2 ASN A 154 -9.030 9.748 16.048 1.00 84.98 N \\\\nATOM 1213 OD1 ASN A 154 -9.725 7.990 17.145 1.00 84.98 O \\\\nATOM 1214 N LEU A 155 -6.959 7.425 19.067 1.00 87.90 N \\\\nATOM 1215 CA LEU A 155 -6.299 8.036 20.228 1.00 87.90 C \\\\nATOM 1216 C LEU A 155 -5.151 7.181 20.790 1.00 87.90 C \\\\nATOM 1217 CB LEU A 155 -7.331 8.347 21.331 1.00 87.90 C \\\\nATOM 1218 O LEU A 155 -4.417 7.667 21.644 1.00 87.90 O \\\\nATOM 1219 CG LEU A 155 -8.442 9.332 20.931 1.00 87.90 C \\\\nATOM 1220 CD1 LEU A 155 -9.445 9.459 22.078 1.00 87.90 C \\\\nATOM 1221 CD2 LEU A 155 -7.894 10.724 20.616 1.00 87.90 C \\\\nATOM 1222 N LYS A 156 -4.992 5.926 20.330 1.00 83.25 N \\\\nATOM 1223 CA LYS A 156 -3.895 5.009 20.710 1.00 83.25 C \\\\nATOM 1224 C LYS A 156 -3.679 4.876 22.230 1.00 83.25 C \\\\nATOM 1225 CB LYS A 156 -2.595 5.394 19.979 1.00 83.25 C \\\\nATOM 1226 O LYS A 156 -2.548 4.755 22.690 1.00 83.25 O \\\\nATOM 1227 CG LYS A 156 -2.698 5.336 18.450 1.00 83.25 C \\\\nATOM 1228 CD LYS A 156 -1.342 5.712 17.841 1.00 83.25 C \\\\nATOM 1229 CE LYS A 156 -1.398 5.654 16.312 1.00 83.25 C \\\\nATOM 1230 NZ LYS A 156 -0.087 6.019 15.718 1.00 83.25 N \\\\nATOM 1231 N LYS A 157 -4.767 4.903 23.003 1.00 86.70 N \\\\nATOM 1232 CA LYS A 157 -4.747 4.689 24.457 1.00 86.70 C \\\\nATOM 1233 C LYS A 157 -4.578 3.207 24.801 1.00 86.70 C \\\\nATOM 1234 CB LYS A 157 -6.028 5.266 25.084 1.00 86.70 C \\\\nATOM 1235 O LYS A 157 -4.794 2.338 23.958 1.00 86.70 O \\\\nATOM 1236 CG LYS A 157 -6.087 6.797 24.984 1.00 86.70 C \\\\nATOM 1237 CD LYS A 157 -7.306 7.338 25.742 1.00 86.70 C \\\\nATOM 1238 CE LYS A 157 -7.300 8.869 25.738 1.00 86.70 C \\\\nATOM 1239 NZ LYS A 157 -8.459 9.409 26.489 1.00 86.70 N \\\\nATOM 1240 N ASP A 158 -4.286 2.931 26.072 1.00 86.03 N \\\\nATOM 1241 CA ASP A 158 -4.174 1.565 26.599 1.00 86.03 C \\\\nATOM 1242 C ASP A 158 -5.472 0.765 26.502 1.00 86.03 C \\\\nATOM 1243 CB ASP A 158 -3.732 1.605 28.067 1.00 86.03 C \\\\nATOM 1244 O ASP A 158 -5.446 -0.463 26.437 1.00 86.03 O \\\\nATOM 1245 CG ASP A 158 -2.309 2.127 28.218 1.00 86.03 C \\\\nATOM 1246 OD1 ASP A 158 -1.483 1.767 27.348 1.00 86.03 O \\\\nATOM 1247 OD2 ASP A 158 -2.084 2.884 29.182 1.00 86.03 O \\\\nATOM 1248 N GLU A 159 -6.611 1.447 26.423 1.00 90.02 N \\\\nATOM 1249 CA GLU A 159 -7.905 0.844 26.152 1.00 90.02 C \\\\nATOM 1250 C GLU A 159 -8.516 1.379 24.857 1.00 90.02 C \\\\nATOM 1251 CB GLU A 159 -8.876 1.060 27.310 1.00 90.02 C \\\\nATOM 1252 O GLU A 159 -8.314 2.531 24.473 1.00 90.02 O \\\\nATOM 1253 CG GLU A 159 -8.393 0.591 28.687 1.00 90.02 C \\\\nATOM 1254 CD GLU A 159 -9.585 0.508 29.654 1.00 90.02 C \\\\nATOM 1255 OE1 GLU A 159 -9.783 -0.580 30.240 1.00 90.02 O \\\\nATOM 1256 OE2 GLU A 159 -10.397 1.463 29.700 1.00 90.02 O \\\\nATOM 1257 N VAL A 160 -9.326 0.542 24.209 1.00 92.39 N \\\\nATOM 1258 CA VAL A 160 -10.071 0.894 22.997 1.00 92.39 C \\\\nATOM 1259 C VAL A 160 -11.570 0.743 23.224 1.00 92.39 C \\\\nATOM 1260 CB VAL A 160 -9.555 0.097 21.785 1.00 92.39 C \\\\nATOM 1261 O VAL A 160 -12.034 -0.267 23.762 1.00 92.39 O \\\\nATOM 1262 CG1 VAL A 160 -9.741 -1.423 21.908 1.00 92.39 C \\\\nATOM 1263 CG2 VAL A 160 -10.216 0.560 20.481 1.00 92.39 C \\\\nATOM 1264 N CYS A 161 -12.340 1.738 22.786 1.00 95.50 N \\\\nATOM 1265 CA CYS A 161 -13.791 1.693 22.797 1.00 95.50 C \\\\nATOM 1266 C CYS A 161 -14.298 0.686 21.760 1.00 95.50 C \\\\nATOM 1267 CB CYS A 161 -14.386 3.086 22.558 1.00 95.50 C \\\\nATOM 1268 O CYS A 161 -13.922 0.727 20.589 1.00 95.50 O \\\\nATOM 1269 SG CYS A 161 -16.167 3.003 22.908 1.00 95.50 S \\\\nATOM 1270 N VAL A 162 -15.186 -0.203 22.184 1.00 94.95 N \\\\nATOM 1271 CA VAL A 162 -15.862 -1.212 21.362 1.00 94.95 C \\\\nATOM 1272 C VAL A 162 -17.372 -0.992 21.289 1.00 94.95 C \\\\nATOM 1273 CB VAL A 162 -15.524 -2.631 21.842 1.00 94.95 C \\\\nATOM 1274 O VAL A 162 -18.089 -1.851 20.781 1.00 94.95 O \\\\nATOM 1275 CG1 VAL A 162 -14.031 -2.924 21.651 1.00 94.95 C \\\\nATOM 1276 CG2 VAL A 162 -15.898 -2.904 23.300 1.00 94.95 C \\\\nATOM 1277 N ASN A 163 -17.863 0.148 21.786 1.00 95.41 N \\\\nATOM 1278 CA ASN A 163 -19.251 0.553 21.605 1.00 95.41 C \\\\nATOM 1279 C ASN A 163 -19.493 0.835 20.110 1.00 95.41 C \\\\nATOM 1280 CB ASN A 163 -19.545 1.782 22.483 1.00 95.41 C \\\\nATOM 1281 O ASN A 163 -18.922 1.790 19.579 1.00 95.41 O \\\\nATOM 1282 CG ASN A 163 -20.991 2.243 22.403 1.00 95.41 C \\\\nATOM 1283 ND2 ASN A 163 -21.418 3.024 23.364 1.00 95.41 N \\\\nATOM 1284 OD1 ASN A 163 -21.735 1.892 21.496 1.00 95.41 O \\\\nATOM 1285 N PRO A 164 -20.333 0.052 19.411 1.00 94.93 N \\\\nATOM 1286 CA PRO A 164 -20.509 0.213 17.974 1.00 94.93 C \\\\nATOM 1287 C PRO A 164 -21.177 1.545 17.590 1.00 94.93 C \\\\nATOM 1288 CB PRO A 164 -21.316 -1.015 17.552 1.00 94.93 C \\\\nATOM 1289 O PRO A 164 -21.033 1.986 16.452 1.00 94.93 O \\\\nATOM 1290 CG PRO A 164 -22.135 -1.362 18.793 1.00 94.93 C \\\\nATOM 1291 CD PRO A 164 -21.163 -1.033 19.920 1.00 94.93 C \\\\nATOM 1292 N TYR A 165 -21.868 2.218 18.518 1.00 95.74 N \\\\nATOM 1293 CA TYR A 165 -22.497 3.531 18.306 1.00 95.74 C \\\\nATOM 1294 C TYR A 165 -21.555 4.711 18.578 1.00 95.74 C \\\\nATOM 1295 CB TYR A 165 -23.792 3.622 19.123 1.00 95.74 C \\\\nATOM 1296 O TYR A 165 -21.940 5.860 18.384 1.00 95.74 O \\\\nATOM 1297 CG TYR A 165 -24.828 2.636 18.631 1.00 95.74 C \\\\nATOM 1298 CD1 TYR A 165 -25.656 2.982 17.546 1.00 95.74 C \\\\nATOM 1299 CD2 TYR A 165 -24.897 1.347 19.187 1.00 95.74 C \\\\nATOM 1300 CE1 TYR A 165 -26.551 2.039 17.010 1.00 95.74 C \\\\nATOM 1301 CE2 TYR A 165 -25.770 0.394 18.630 1.00 95.74 C \\\\nATOM 1302 OH TYR A 165 -27.473 -0.173 17.044 1.00 95.74 O \\\\nATOM 1303 CZ TYR A 165 -26.611 0.741 17.555 1.00 95.74 C \\\\nATOM 1304 N HIS A 166 -20.311 4.438 18.983 1.00 96.55 N \\\\nATOM 1305 CA HIS A 166 -19.236 5.436 19.062 1.00 96.55 C \\\\nATOM 1306 C HIS A 166 -18.425 5.553 17.774 1.00 96.55 C \\\\nATOM 1307 CB HIS A 166 -18.339 5.141 20.265 1.00 96.55 C \\\\nATOM 1308 O HIS A 166 -17.483 6.337 17.705 1.00 96.55 O \\\\nATOM 1309 CG HIS A 166 -18.963 5.469 21.593 1.00 96.55 C \\\\nATOM 1310 CD2 HIS A 166 -20.246 5.881 21.816 1.00 96.55 C \\\\nATOM 1311 ND1 HIS A 166 -18.243 5.555 22.785 1.00 96.55 N \\\\nATOM 1312 CE1 HIS A 166 -19.104 6.056 23.681 1.00 96.55 C \\\\nATOM 1313 NE2 HIS A 166 -20.313 6.236 23.137 1.00 96.55 N \\\\nATOM 1314 N TYR A 167 -18.809 4.800 16.749 1.00 95.99 N \\\\nATOM 1315 CA TYR A 167 -18.234 4.870 15.418 1.00 95.99 C \\\\nATOM 1316 C TYR A 167 -19.323 5.244 14.415 1.00 95.99 C \\\\nATOM 1317 CB TYR A 167 -17.535 3.543 15.095 1.00 95.99 C \\\\nATOM 1318 O TYR A 167 -20.494 4.939 14.606 1.00 95.99 O \\\\nATOM 1319 CG TYR A 167 -16.391 3.227 16.045 1.00 95.99 C \\\\nATOM 1320 CD1 TYR A 167 -15.102 3.728 15.781 1.00 95.99 C \\\\nATOM 1321 CD2 TYR A 167 -16.626 2.488 17.222 1.00 95.99 C \\\\nATOM 1322 CE1 TYR A 167 -14.053 3.494 16.690 1.00 95.99 C \\\\nATOM 1323 CE2 TYR A 167 -15.583 2.263 18.142 1.00 95.99 C \\\\nATOM 1324 OH TYR A 167 -13.262 2.544 18.736 1.00 95.99 O \\\\nATOM 1325 CZ TYR A 167 -14.291 2.772 17.876 1.00 95.99 C \\\\nATOM 1326 N GLN A 168 -18.962 5.909 13.336 1.00 93.44 N \\\\nATOM 1327 CA GLN A 168 -19.802 6.190 12.182 1.00 93.44 C \\\\nATOM 1328 C GLN A 168 -19.122 5.567 10.971 1.00 93.44 C \\\\nATOM 1329 CB GLN A 168 -19.992 7.702 12.024 1.00 93.44 C \\\\nATOM 1330 O GLN A 168 -17.891 5.559 10.897 1.00 93.44 O \\\\nATOM 1331 CG GLN A 168 -20.874 8.284 13.141 1.00 93.44 C \\\\nATOM 1332 CD GLN A 168 -20.992 9.804 13.068 1.00 93.44 C \\\\nATOM 1333 NE2 GLN A 168 -21.814 10.413 13.894 1.00 93.44 N \\\\nATOM 1334 OE1 GLN A 168 -20.336 10.479 12.298 1.00 93.44 O \\\\nATOM 1335 N ARG A 169 -19.905 5.005 10.051 1.00 91.38 N \\\\nATOM 1336 CA ARG A 169 -19.352 4.515 8.793 1.00 91.38 C \\\\nATOM 1337 C ARG A 169 -18.992 5.723 7.940 1.00 91.38 C \\\\nATOM 1338 CB ARG A 169 -20.329 3.558 8.104 1.00 91.38 C \\\\nATOM 1339 O ARG A 169 -19.748 6.688 7.908 1.00 91.38 O \\\\nATOM 1340 CG ARG A 169 -19.688 2.835 6.915 1.00 91.38 C \\\\nATOM 1341 CD ARG A 169 -20.634 1.759 6.375 1.00 91.38 C \\\\nATOM 1342 NE ARG A 169 -19.942 0.894 5.407 1.00 91.38 N \\\\nATOM 1343 NH1 ARG A 169 -21.627 -0.625 5.046 1.00 91.38 N \\\\nATOM 1344 NH2 ARG A 169 -19.646 -0.939 4.109 1.00 91.38 N \\\\nATOM 1345 CZ ARG A 169 -20.411 -0.206 4.856 1.00 91.38 C \\\\nATOM 1346 N VAL A 170 -17.837 5.680 7.296 1.00 88.40 N \\\\nATOM 1347 CA VAL A 170 -17.450 6.695 6.318 1.00 88.40 C \\\\nATOM 1348 C VAL A 170 -18.362 6.528 5.104 1.00 88.40 C \\\\nATOM 1349 CB VAL A 170 -15.959 6.576 5.956 1.00 88.40 C \\\\nATOM 1350 O VAL A 170 -18.325 5.495 4.438 1.00 88.40 O \\\\nATOM 1351 CG1 VAL A 170 -15.564 7.639 4.927 1.00 88.40 C \\\\nATOM 1352 CG2 VAL A 170 -15.075 6.775 7.199 1.00 88.40 C \\\\nATOM 1353 N GLU A 171 -19.219 7.514 4.864 1.00 82.22 N \\\\nATOM 1354 CA GLU A 171 -20.124 7.540 3.715 1.00 82.22 C \\\\nATOM 1355 C GLU A 171 -19.408 8.133 2.499 1.00 82.22 C \\\\nATOM 1356 CB GLU A 171 -21.407 8.317 4.059 1.00 82.22 C \\\\nATOM 1357 O GLU A 171 -18.624 9.076 2.625 1.00 82.22 O \\\\nATOM 1358 CG GLU A 171 -22.244 7.575 5.118 1.00 82.22 C \\\\nATOM 1359 CD GLU A 171 -23.545 8.288 5.520 1.00 82.22 C \\\\nATOM 1360 OE1 GLU A 171 -24.246 7.719 6.392 1.00 82.22 O \\\\nATOM 1361 OE2 GLU A 171 -23.828 9.381 4.983 1.00 82.22 O \\\\nATOM 1362 N THR A 172 -19.669 7.580 1.313 1.00 80.03 N \\\\nATOM 1363 CA THR A 172 -19.195 8.172 0.059 1.00 80.03 C \\\\nATOM 1364 C THR A 172 -20.025 9.421 -0.233 1.00 80.03 C \\\\nATOM 1365 CB THR A 172 -19.256 7.179 -1.107 1.00 80.03 C \\\\nATOM 1366 O THR A 172 -21.246 9.310 -0.362 1.00 80.03 O \\\\nATOM 1367 CG2 THR A 172 -18.685 7.755 -2.404 1.00 80.03 C \\\\nATOM 1368 OG1 THR A 172 -18.475 6.045 -0.796 1.00 80.03 O \\\\nATOM 1369 N PRO A 173 -19.405 10.609 -0.330 1.00 80.47 N \\\\nATOM 1370 CA PRO A 173 -20.132 11.834 -0.616 1.00 80.47 C \\\\nATOM 1371 C PRO A 173 -20.764 11.762 -2.009 1.00 80.47 C \\\\nATOM 1372 CB PRO A 173 -19.098 12.954 -0.499 1.00 80.47 C \\\\nATOM 1373 O PRO A 173 -20.144 11.285 -2.960 1.00 80.47 O \\\\nATOM 1374 CG PRO A 173 -17.772 12.263 -0.826 1.00 80.47 C \\\\nATOM 1375 CD PRO A 173 -17.973 10.853 -0.292 1.00 80.47 C \\\\nATOM 1376 N VAL A 174 -21.991 12.272 -2.140 1.00 82.51 N \\\\nATOM 1377 CA VAL A 174 -22.652 12.398 -3.445 1.00 82.51 C \\\\nATOM 1378 C VAL A 174 -21.908 13.453 -4.264 1.00 82.51 C \\\\nATOM 1379 CB VAL A 174 -24.147 12.744 -3.305 1.00 82.51 C \\\\nATOM 1380 O VAL A 174 -21.784 14.602 -3.839 1.00 82.51 O \\\\nATOM 1381 CG1 VAL A 174 -24.830 12.822 -4.677 1.00 82.51 C \\\\nATOM 1382 CG2 VAL A 174 -24.885 11.685 -2.474 1.00 82.51 C \\\\nATOM 1383 N LEU A 175 -21.392 13.056 -5.426 1.00 85.88 N \\\\nATOM 1384 CA LEU A 175 -20.677 13.953 -6.333 1.00 85.88 C \\\\nATOM 1385 C LEU A 175 -21.683 14.739 -7.196 1.00 85.88 C \\\\nATOM 1386 CB LEU A 175 -19.685 13.147 -7.190 1.00 85.88 C \\\\nATOM 1387 O LEU A 175 -22.635 14.137 -7.702 1.00 85.88 O \\\\nATOM 1388 CG LEU A 175 -18.604 12.400 -6.386 1.00 85.88 C \\\\nATOM 1389 CD1 LEU A 175 -17.801 11.463 -7.283 1.00 85.88 C \\\\nATOM 1390 CD2 LEU A 175 -17.627 13.363 -5.708 1.00 85.88 C \\\\nATOM 1391 N PRO A 176 -21.506 16.062 -7.378 1.00 86.02 N \\\\nATOM 1392 CA PRO A 176 -22.392 16.857 -8.224 1.00 86.02 C \\\\nATOM 1393 C PRO A 176 -22.263 16.431 -9.698 1.00 86.02 C \\\\nATOM 1394 CB PRO A 176 -21.967 18.312 -8.009 1.00 86.02 C \\\\nATOM 1395 O PRO A 176 -21.165 16.064 -10.123 1.00 86.02 O \\\\nATOM 1396 CG PRO A 176 -20.483 18.195 -7.657 1.00 86.02 C \\\\nATOM 1397 CD PRO A 176 -20.411 16.882 -6.878 1.00 86.02 C \\\\nATOM 1398 N PRO A 177 -23.344 16.482 -10.499 1.00 87.29 N \\\\nATOM 1399 CA PRO A 177 -23.257 16.213 -11.931 1.00 87.29 C \\\\nATOM 1400 C PRO A 177 -22.373 17.251 -12.631 1.00 87.29 C \\\\nATOM 1401 CB PRO A 177 -24.697 16.255 -12.451 1.00 87.29 C \\\\nATOM 1402 O PRO A 177 -22.425 18.440 -12.314 1.00 87.29 O \\\\nATOM 1403 CG PRO A 177 -25.403 17.184 -11.463 1.00 87.29 C \\\\nATOM 1404 CD PRO A 177 -24.688 16.909 -10.139 1.00 87.29 C \\\\nATOM 1405 N VAL A 178 -21.600 16.805 -13.619 1.00 87.57 N \\\\nATOM 1406 CA VAL A 178 -20.834 17.696 -14.500 1.00 87.57 C \\\\nATOM 1407 C VAL A 178 -21.767 18.192 -15.599 1.00 87.57 C \\\\nATOM 1408 CB VAL A 178 -19.596 16.981 -15.070 1.00 87.57 C \\\\nATOM 1409 O VAL A 178 -22.409 17.384 -16.266 1.00 87.57 O \\\\nATOM 1410 CG1 VAL A 178 -18.864 17.835 -16.108 1.00 87.57 C \\\\nATOM 1411 CG2 VAL A 178 -18.600 16.666 -13.950 1.00 87.57 C \\\\nATOM 1412 N LEU A 179 -21.873 19.509 -15.769 1.00 87.79 N \\\\nATOM 1413 CA LEU A 179 -22.702 20.119 -16.808 1.00 87.79 C \\\\nATOM 1414 C LEU A 179 -21.874 20.288 -18.081 1.00 87.79 C \\\\nATOM 1415 CB LEU A 179 -23.254 21.470 -16.317 1.00 87.79 C \\\\nATOM 1416 O LEU A 179 -20.872 20.998 -18.060 1.00 87.79 O \\\\nATOM 1417 CG LEU A 179 -24.097 21.415 -15.032 1.00 87.79 C \\\\nATOM 1418 CD1 LEU A 179 -24.620 22.811 -14.697 1.00 87.79 C \\\\nATOM 1419 CD2 LEU A 179 -25.295 20.471 -15.156 1.00 87.79 C \\\\nATOM 1420 N VAL A 180 -22.289 19.647 -19.172 1.00 84.28 N \\\\nATOM 1421 CA VAL A 180 -21.601 19.720 -20.466 1.00 84.28 C \\\\nATOM 1422 C VAL A 180 -22.396 20.613 -21.422 1.00 84.28 C \\\\nATOM 1423 CB VAL A 180 -21.359 18.323 -21.065 1.00 84.28 C \\\\nATOM 1424 O VAL A 180 -23.571 20.321 -21.665 1.00 84.28 O \\\\nATOM 1425 CG1 VAL A 180 -20.531 18.447 -22.348 1.00 84.28 C \\\\nATOM 1426 CG2 VAL A 180 -20.586 17.436 -20.078 1.00 84.28 C \\\\nATOM 1427 N PRO A 181 -21.807 21.693 -21.967 1.00 78.12 N \\\\nATOM 1428 CA PRO A 181 -22.442 22.482 -23.017 1.00 78.12 C \\\\nATOM 1429 C PRO A 181 -22.627 21.643 -24.281 1.00 78.12 C \\\\nATOM 1430 CB PRO A 181 -21.519 23.687 -23.260 1.00 78.12 C \\\\nATOM 1431 O PRO A 181 -21.658 21.102 -24.813 1.00 78.12 O \\\\nATOM 1432 CG PRO A 181 -20.643 23.753 -22.010 1.00 78.12 C \\\\nATOM 1433 CD PRO A 181 -20.538 22.293 -21.584 1.00 78.12 C \\\\nATOM 1434 N ARG A 182 -23.855 21.550 -24.801 1.00 67.49 N \\\\nATOM 1435 CA ARG A 182 -24.062 21.007 -26.146 1.00 67.49 C \\\\nATOM 1436 C ARG A 182 -23.515 21.998 -27.170 1.00 67.49 C \\\\nATOM 1437 CB ARG A 182 -25.542 20.692 -26.386 1.00 67.49 C \\\\nATOM 1438 O ARG A 182 -23.953 23.146 -27.230 1.00 67.49 O \\\\nATOM 1439 CG ARG A 182 -25.978 19.452 -25.594 1.00 67.49 C \\\\nATOM 1440 CD ARG A 182 -27.438 19.144 -25.917 1.00 67.49 C \\\\nATOM 1441 NE ARG A 182 -27.885 17.885 -25.302 1.00 67.49 N \\\\nATOM 1442 NH1 ARG A 182 -30.126 18.198 -25.717 1.00 67.49 N \\\\nATOM 1443 NH2 ARG A 182 -29.440 16.332 -24.732 1.00 67.49 N \\\\nATOM 1444 CZ ARG A 182 -29.139 17.478 -25.265 1.00 67.49 C \\\\nATOM 1445 N HIS A 183 -22.548 21.562 -27.974 1.00 57.15 N \\\\nATOM 1446 CA HIS A 183 -22.051 22.350 -29.097 1.00 57.15 C \\\\nATOM 1447 C HIS A 183 -23.143 22.490 -30.162 1.00 57.15 C \\\\nATOM 1448 CB HIS A 183 -20.776 21.713 -29.680 1.00 57.15 C \\\\nATOM 1449 O HIS A 183 -23.293 21.614 -31.012 1.00 57.15 O \\\\nATOM 1450 CG HIS A 183 -19.515 22.141 -28.978 1.00 57.15 C \\\\nATOM 1451 CD2 HIS A 183 -18.673 21.359 -28.233 1.00 57.15 C \\\\nATOM 1452 ND1 HIS A 183 -18.973 23.407 -29.012 1.00 57.15 N \\\\nATOM 1453 CE1 HIS A 183 -17.836 23.388 -28.298 1.00 57.15 C \\\\nATOM 1454 NE2 HIS A 183 -17.608 22.162 -27.810 1.00 57.15 N \\\\nATOM 1455 N THR A 184 -23.876 23.605 -30.134 1.00 46.80 N \\\\nATOM 1456 CA THR A 184 -24.677 24.042 -31.286 1.00 46.80 C \\\\nATOM 1457 C THR A 184 -23.954 25.106 -32.118 1.00 46.80 C \\\\nATOM 1458 CB THR A 184 -26.113 24.462 -30.917 1.00 46.80 C \\\\nATOM 1459 O THR A 184 -24.179 25.140 -33.319 1.00 46.80 O \\\\nATOM 1460 CG2 THR A 184 -27.094 24.160 -32.053 1.00 46.80 C \\\\nATOM 1461 OG1 THR A 184 -26.596 23.744 -29.802 1.00 46.80 O \\\\nATOM 1462 N GLU A 185 -23.029 25.915 -31.574 1.00 42.59 N \\\\nATOM 1463 CA GLU A 185 -22.300 26.939 -32.355 1.00 42.59 C \\\\nATOM 1464 C GLU A 185 -20.865 27.188 -31.829 1.00 42.59 C \\\\nATOM 1465 CB GLU A 185 -23.118 28.248 -32.437 1.00 42.59 C \\\\nATOM 1466 O GLU A 185 -20.599 27.141 -30.628 1.00 42.59 O \\\\nATOM 1467 CG GLU A 185 -24.438 28.065 -33.220 1.00 42.59 C \\\\nATOM 1468 CD GLU A 185 -25.260 29.335 -33.440 1.00 42.59 C \\\\nATOM 1469 OE1 GLU A 185 -26.206 29.262 -34.258 1.00 42.59 O \\\\nATOM 1470 OE2 GLU A 185 -24.976 30.351 -32.769 1.00 42.59 O \\\\nATOM 1471 N ILE A 186 -19.920 27.403 -32.751 1.00 43.70 N \\\\nATOM 1472 CA ILE A 186 -18.473 27.564 -32.524 1.00 43.70 C \\\\nATOM 1473 C ILE A 186 -18.190 28.959 -31.940 1.00 43.70 C \\\\nATOM 1474 CB ILE A 186 -17.731 27.351 -33.876 1.00 43.70 C \\\\nATOM 1475 O ILE A 186 -18.321 29.960 -32.645 1.00 43.70 O \\\\nATOM 1476 CG1 ILE A 186 -17.917 25.903 -34.397 1.00 43.70 C \\\\nATOM 1477 CG2 ILE A 186 -16.227 27.681 -33.786 1.00 43.70 C \\\\nATOM 1478 CD1 ILE A 186 -17.621 25.743 -35.895 1.00 43.70 C \\\\nATOM 1479 N LEU A 187 -17.743 29.045 -30.682 1.00 41.65 N \\\\nATOM 1480 CA LEU A 187 -17.145 30.279 -30.164 1.00 41.65 C \\\\nATOM 1481 C LEU A 187 -15.734 30.433 -30.738 1.00 41.65 C \\\\nATOM 1482 CB LEU A 187 -17.170 30.334 -28.626 1.00 41.65 C \\\\nATOM 1483 O LEU A 187 -14.805 29.707 -30.389 1.00 41.65 O \\\\nATOM 1484 CG LEU A 187 -18.565 30.585 -28.022 1.00 41.65 C \\\\nATOM 1485 CD1 LEU A 187 -18.455 30.600 -26.497 1.00 41.65 C \\\\nATOM 1486 CD2 LEU A 187 -19.178 31.921 -28.456 1.00 41.65 C \\\\nATOM 1487 N THR A 188 -15.608 31.387 -31.655 1.00 39.88 N \\\\nATOM 1488 CA THR A 188 -14.369 31.743 -32.347 1.00 39.88 C \\\\nATOM 1489 C THR A 188 -13.667 32.847 -31.557 1.00 39.88 C \\\\nATOM 1490 CB THR A 188 -14.652 32.176 -33.805 1.00 39.88 C \\\\nATOM 1491 O THR A 188 -13.729 33.993 -31.963 1.00 39.88 O \\\\nATOM 1492 CG2 THR A 188 -13.409 32.051 -34.686 1.00 39.88 C \\\\nATOM 1493 OG1 THR A 188 -15.632 31.356 -34.407 1.00 39.88 O \\\\nATOM 1494 N GLU A 189 -13.096 32.520 -30.393 1.00 39.17 N \\\\nATOM 1495 CA GLU A 189 -12.008 33.261 -29.717 1.00 39.17 C \\\\nATOM 1496 C GLU A 189 -11.721 32.594 -28.357 1.00 39.17 C \\\\nATOM 1497 CB GLU A 189 -12.299 34.776 -29.537 1.00 39.17 C \\\\nATOM 1498 O GLU A 189 -12.476 32.743 -27.398 1.00 39.17 O \\\\nATOM 1499 CG GLU A 189 -11.503 35.615 -30.564 1.00 39.17 C \\\\nATOM 1500 CD GLU A 189 -11.864 37.112 -30.592 1.00 39.17 C \\\\nATOM 1501 OE1 GLU A 189 -11.347 37.804 -31.501 1.00 39.17 O \\\\nATOM 1502 OE2 GLU A 189 -12.600 37.578 -29.692 1.00 39.17 O \\\\nATOM 1503 N LEU A 190 -10.632 31.819 -28.274 1.00 46.02 N \\\\nATOM 1504 CA LEU A 190 -10.084 31.291 -27.019 1.00 46.02 C \\\\nATOM 1505 C LEU A 190 -8.787 32.052 -26.685 1.00 46.02 C \\\\nATOM 1506 CB LEU A 190 -9.839 29.770 -27.126 1.00 46.02 C \\\\nATOM 1507 O LEU A 190 -7.996 32.310 -27.598 1.00 46.02 O \\\\nATOM 1508 CG LEU A 190 -11.069 28.909 -26.773 1.00 46.02 C \\\\nATOM 1509 CD1 LEU A 190 -10.925 27.510 -27.372 1.00 46.02 C \\\\nATOM 1510 CD2 LEU A 190 -11.236 28.751 -25.258 1.00 46.02 C \\\\nATOM 1511 N PRO A 191 -8.544 32.405 -25.407 1.00 44.40 N \\\\nATOM 1512 CA PRO A 191 -7.281 32.997 -24.973 1.00 44.40 C \\\\nATOM 1513 C PRO A 191 -6.117 32.019 -25.213 1.00 44.40 C \\\\nATOM 1514 CB PRO A 191 -7.478 33.357 -23.496 1.00 44.40 C \\\\nATOM 1515 O PRO A 191 -6.349 30.810 -25.301 1.00 44.40 O \\\\nATOM 1516 CG PRO A 191 -8.582 32.417 -23.018 1.00 44.40 C \\\\nATOM 1517 CD PRO A 191 -9.399 32.116 -24.270 1.00 44.40 C \\\\nATOM 1518 N PRO A 192 -4.872 32.515 -25.343 1.00 44.87 N \\\\nATOM 1519 CA PRO A 192 -3.722 31.678 -25.668 1.00 44.87 C \\\\nATOM 1520 C PRO A 192 -3.588 30.547 -24.642 1.00 44.87 C \\\\nATOM 1521 CB PRO A 192 -2.510 32.619 -25.694 1.00 44.87 C \\\\nATOM 1522 O PRO A 192 -3.456 30.796 -23.446 1.00 44.87 O \\\\nATOM 1523 CG PRO A 192 -2.947 33.804 -24.832 1.00 44.87 C \\\\nATOM 1524 CD PRO A 192 -4.452 33.878 -25.071 1.00 44.87 C \\\\nATOM 1525 N LEU A 193 -3.669 29.307 -25.127 1.00 47.96 N \\\\nATOM 1526 CA LEU A 193 -3.348 28.114 -24.354 1.00 47.96 C \\\\nATOM 1527 C LEU A 193 -1.859 28.168 -24.002 1.00 47.96 C \\\\nATOM 1528 CB LEU A 193 -3.669 26.855 -25.189 1.00 47.96 C \\\\nATOM 1529 O LEU A 193 -1.025 28.289 -24.900 1.00 47.96 O \\\\nATOM 1530 CG LEU A 193 -5.169 26.516 -25.287 1.00 47.96 C \\\\nATOM 1531 CD1 LEU A 193 -5.420 25.532 -26.432 1.00 47.96 C \\\\nATOM 1532 CD2 LEU A 193 -5.678 25.874 -23.994 1.00 47.96 C \\\\nATOM 1533 N ASP A 194 -1.534 28.058 -22.714 1.00 43.48 N \\\\nATOM 1534 CA ASP A 194 -0.163 27.779 -22.297 1.00 43.48 C \\\\nATOM 1535 C ASP A 194 0.288 26.455 -22.931 1.00 43.48 C \\\\nATOM 1536 CB ASP A 194 -0.029 27.747 -20.764 1.00 43.48 C \\\\nATOM 1537 O ASP A 194 -0.447 25.463 -22.966 1.00 43.48 O \\\\nATOM 1538 CG ASP A 194 0.055 29.139 -20.120 1.00 43.48 C \\\\nATOM 1539 OD1 ASP A 194 0.655 30.045 -20.741 1.00 43.48 O \\\\nATOM 1540 OD2 ASP A 194 -0.427 29.269 -18.971 1.00 43.48 O \\\\nATOM 1541 N ASP A 195 1.502 26.463 -23.471 1.00 40.98 N \\\\nATOM 1542 CA ASP A 195 2.109 25.353 -24.193 1.00 40.98 C \\\\nATOM 1543 C ASP A 195 2.381 24.181 -23.226 1.00 40.98 C \\\\nATOM 1544 CB ASP A 195 3.357 25.896 -24.920 1.00 40.98 C \\\\nATOM 1545 O ASP A 195 3.425 24.073 -22.582 1.00 40.98 O \\\\nATOM 1546 CG ASP A 195 3.821 25.038 -26.099 1.00 40.98 C \\\\nATOM 1547 OD1 ASP A 195 3.338 23.887 -26.222 1.00 40.98 O \\\\nATOM 1548 OD2 ASP A 195 4.683 25.520 -26.864 1.00 40.98 O \\\\nATOM 1549 N TYR A 196 1.401 23.287 -23.074 1.00 45.99 N \\\\nATOM 1550 CA TYR A 196 1.498 22.073 -22.256 1.00 45.99 C \\\\nATOM 1551 C TYR A 196 2.280 20.949 -22.954 1.00 45.99 C \\\\nATOM 1552 CB TYR A 196 0.104 21.626 -21.782 1.00 45.99 C \\\\nATOM 1553 O TYR A 196 2.133 19.776 -22.601 1.00 45.99 O \\\\nATOM 1554 CG TYR A 196 -0.449 22.425 -20.621 1.00 45.99 C \\\\nATOM 1555 CD1 TYR A 196 0.004 22.188 -19.305 1.00 45.99 C \\\\nATOM 1556 CD2 TYR A 196 -1.435 23.397 -20.858 1.00 45.99 C \\\\nATOM 1557 CE1 TYR A 196 -0.532 22.927 -18.231 1.00 45.99 C \\\\nATOM 1558 CE2 TYR A 196 -1.974 24.134 -19.790 1.00 45.99 C \\\\nATOM 1559 OH TYR A 196 -2.055 24.617 -17.450 1.00 45.99 O \\\\nATOM 1560 CZ TYR A 196 -1.526 23.902 -18.477 1.00 45.99 C \\\\nATOM 1561 N THR A 197 3.168 21.259 -23.899 1.00 44.07 N \\\\nATOM 1562 CA THR A 197 4.138 20.294 -24.449 1.00 44.07 C \\\\nATOM 1563 C THR A 197 5.068 19.704 -23.373 1.00 44.07 C \\\\nATOM 1564 CB THR A 197 4.937 20.916 -25.605 1.00 44.07 C \\\\nATOM 1565 O THR A 197 5.636 18.633 -23.572 1.00 44.07 O \\\\nATOM 1566 CG2 THR A 197 4.119 20.933 -26.895 1.00 44.07 C \\\\nATOM 1567 OG1 THR A 197 5.316 22.233 -25.300 1.00 44.07 O \\\\nATOM 1568 N HIS A 198 5.111 20.292 -22.171 1.00 42.09 N \\\\nATOM 1569 CA HIS A 198 5.744 19.726 -20.969 1.00 42.09 C \\\\nATOM 1570 C HIS A 198 4.830 18.831 -20.098 1.00 42.09 C \\\\nATOM 1571 CB HIS A 198 6.354 20.877 -20.161 1.00 42.09 C \\\\nATOM 1572 O HIS A 198 5.241 18.362 -19.037 1.00 42.09 O \\\\nATOM 1573 CG HIS A 198 7.428 21.607 -20.924 1.00 42.09 C \\\\nATOM 1574 CD2 HIS A 198 7.425 22.924 -21.302 1.00 42.09 C \\\\nATOM 1575 ND1 HIS A 198 8.589 21.047 -21.409 1.00 42.09 N \\\\nATOM 1576 CE1 HIS A 198 9.273 22.005 -22.054 1.00 42.09 C \\\\nATOM 1577 NE2 HIS A 198 8.615 23.170 -21.994 1.00 42.09 N \\\\nATOM 1578 N SER A 199 3.585 18.569 -20.513 1.00 43.75 N \\\\nATOM 1579 CA SER A 199 2.611 17.784 -19.731 1.00 43.75 C \\\\nATOM 1580 C SER A 199 2.780 16.269 -19.848 1.00 43.75 C \\\\nATOM 1581 CB SER A 199 1.176 18.147 -20.110 1.00 43.75 C \\\\nATOM 1582 O SER A 199 2.189 15.538 -19.049 1.00 43.75 O \\\\nATOM 1583 OG SER A 199 0.904 17.723 -21.433 1.00 43.75 O \\\\nATOM 1584 N ILE A 200 3.559 15.781 -20.821 1.00 42.94 N \\\\nATOM 1585 CA ILE A 200 4.083 14.414 -20.812 1.00 42.94 C \\\\nATOM 1586 C ILE A 200 5.367 14.491 -20.005 1.00 42.94 C \\\\nATOM 1587 CB ILE A 200 4.378 13.862 -22.226 1.00 42.94 C \\\\nATOM 1588 O ILE A 200 6.360 15.025 -20.501 1.00 42.94 O \\\\nATOM 1589 CG1 ILE A 200 3.113 13.892 -23.105 1.00 42.94 C \\\\nATOM 1590 CG2 ILE A 200 4.921 12.419 -22.113 1.00 42.94 C \\\\nATOM 1591 CD1 ILE A 200 3.385 13.574 -24.580 1.00 42.94 C \\\\nATOM 1592 N PRO A 201 5.411 13.973 -18.773 1.00 48.89 N \\\\nATOM 1593 CA PRO A 201 6.698 13.882 -18.145 1.00 48.89 C \\\\nATOM 1594 C PRO A 201 7.513 12.838 -18.892 1.00 48.89 C \\\\nATOM 1595 CB PRO A 201 6.435 13.536 -16.703 1.00 48.89 C \\\\nATOM 1596 O PRO A 201 7.066 11.701 -19.058 1.00 48.89 O \\\\nATOM 1597 CG PRO A 201 4.922 13.301 -16.558 1.00 48.89 C \\\\nATOM 1598 CD PRO A 201 4.381 13.323 -17.983 1.00 48.89 C \\\\nATOM 1599 N GLU A 202 8.725 13.207 -19.300 1.00 54.78 N \\\\nATOM 1600 CA GLU A 202 9.679 12.321 -19.981 1.00 54.78 C \\\\nATOM 1601 C GLU A 202 9.876 10.989 -19.236 1.00 54.78 C \\\\nATOM 1602 CB GLU A 202 11.032 13.036 -20.092 1.00 54.78 C \\\\nATOM 1603 O GLU A 202 10.212 9.968 -19.833 1.00 54.78 O \\\\nATOM 1604 CG GLU A 202 11.007 14.228 -21.061 1.00 54.78 C \\\\nATOM 1605 CD GLU A 202 12.381 14.908 -21.171 1.00 54.78 C \\\\nATOM 1606 OE1 GLU A 202 12.648 15.502 -22.237 1.00 54.78 O \\\\nATOM 1607 OE2 GLU A 202 13.154 14.818 -20.188 1.00 54.78 O \\\\nATOM 1608 N ASN A 203 9.570 10.956 -17.934 1.00 64.59 N \\\\nATOM 1609 CA ASN A 203 9.573 9.748 -17.121 1.00 64.59 C \\\\nATOM 1610 C ASN A 203 8.459 8.712 -17.415 1.00 64.59 C \\\\nATOM 1611 CB ASN A 203 9.696 10.114 -15.636 1.00 64.59 C \\\\nATOM 1612 O ASN A 203 8.453 7.652 -16.776 1.00 64.59 O \\\\nATOM 1613 CG ASN A 203 8.514 10.710 -14.914 1.00 64.59 C \\\\nATOM 1614 ND2 ASN A 203 8.751 11.229 -13.733 1.00 64.59 N \\\\nATOM 1615 OD1 ASN A 203 7.370 10.626 -15.308 1.00 64.59 O \\\\nATOM 1616 N THR A 204 7.555 8.980 -18.366 1.00 56.41 N \\\\nATOM 1617 CA THR A 204 6.367 8.156 -18.675 1.00 56.41 C \\\\nATOM 1618 C THR A 204 6.367 7.475 -20.049 1.00 56.41 C \\\\nATOM 1619 CB THR A 204 5.059 8.951 -18.512 1.00 56.41 C \\\\nATOM 1620 O THR A 204 5.433 6.726 -20.332 1.00 56.41 O \\\\nATOM 1621 CG2 THR A 204 4.880 9.530 -17.113 1.00 56.41 C \\\\nATOM 1622 OG1 THR A 204 4.971 10.026 -19.414 1.00 56.41 O \\\\nATOM 1623 N ASN A 205 7.384 7.676 -20.897 1.00 49.30 N \\\\nATOM 1624 CA ASN A 205 7.339 7.163 -22.271 1.00 49.30 C \\\\nATOM 1625 C ASN A 205 7.411 5.624 -22.351 1.00 49.30 C \\\\nATOM 1626 CB ASN A 205 8.401 7.859 -23.157 1.00 49.30 C \\\\nATOM 1627 O ASN A 205 8.383 4.995 -21.919 1.00 49.30 O \\\\nATOM 1628 CG ASN A 205 7.823 8.911 -24.097 1.00 49.30 C \\\\nATOM 1629 ND2 ASN A 205 8.634 9.491 -24.948 1.00 49.30 N \\\\nATOM 1630 OD1 ASN A 205 6.647 9.226 -24.088 1.00 49.30 O \\\\nATOM 1631 N PHE A 206 6.385 5.039 -22.974 1.00 41.13 N \\\\nATOM 1632 CA PHE A 206 6.423 3.713 -23.590 1.00 41.13 C \\\\nATOM 1633 C PHE A 206 6.857 3.858 -25.057 1.00 41.13 C \\\\nATOM 1634 CB PHE A 206 5.035 3.059 -23.535 1.00 41.13 C \\\\nATOM 1635 O PHE A 206 6.550 4.880 -25.673 1.00 41.13 O \\\\nATOM 1636 CG PHE A 206 4.514 2.747 -22.147 1.00 41.13 C \\\\nATOM 1637 CD1 PHE A 206 4.761 1.489 -21.561 1.00 41.13 C \\\\nATOM 1638 CD2 PHE A 206 3.716 3.689 -21.474 1.00 41.13 C \\\\nATOM 1639 CE1 PHE A 206 4.166 1.158 -20.330 1.00 41.13 C \\\\nATOM 1640 CE2 PHE A 206 3.120 3.357 -20.247 1.00 41.13 C \\\\nATOM 1641 CZ PHE A 206 3.318 2.084 -19.694 1.00 41.13 C \\\\nATOM 1642 N PRO A 207 7.522 2.860 -25.663 1.00 35.10 N \\\\nATOM 1643 CA PRO A 207 7.728 2.862 -27.104 1.00 35.10 C \\\\nATOM 1644 C PRO A 207 6.383 2.618 -27.804 1.00 35.10 C \\\\nATOM 1645 CB PRO A 207 8.771 1.770 -27.363 1.00 35.10 C \\\\nATOM 1646 O PRO A 207 5.911 1.486 -27.892 1.00 35.10 O \\\\nATOM 1647 CG PRO A 207 8.559 0.782 -26.214 1.00 35.10 C \\\\nATOM 1648 CD PRO A 207 8.049 1.647 -25.059 1.00 35.10 C \\\\nATOM 1649 N ALA A 208 5.752 3.680 -28.303 1.00 33.84 N \\\\nATOM 1650 CA ALA A 208 4.773 3.562 -29.375 1.00 33.84 C \\\\nATOM 1651 C ALA A 208 5.554 3.220 -30.654 1.00 33.84 C \\\\nATOM 1652 CB ALA A 208 3.977 4.870 -29.479 1.00 33.84 C \\\\nATOM 1653 O ALA A 208 6.194 4.086 -31.242 1.00 33.84 O \\\\nATOM 1654 N GLY A 209 5.598 1.936 -31.016 1.00 29.29 N \\\\nATOM 1655 CA GLY A 209 6.338 1.481 -32.193 1.00 29.29 C \\\\nATOM 1656 C GLY A 209 6.670 -0.006 -32.166 1.00 29.29 C \\\\nATOM 1657 O GLY A 209 7.836 -0.376 -32.081 1.00 29.29 O \\\\nATOM 1658 N ILE A 210 5.653 -0.865 -32.237 1.00 34.22 N \\\\nATOM 1659 CA ILE A 210 5.816 -2.192 -32.838 1.00 34.22 C \\\\nATOM 1660 C ILE A 210 4.875 -2.199 -34.036 1.00 34.22 C \\\\nATOM 1661 CB ILE A 210 5.576 -3.353 -31.843 1.00 34.22 C \\\\nATOM 1662 O ILE A 210 3.655 -2.203 -33.873 1.00 34.22 O \\\\nATOM 1663 CG1 ILE A 210 6.570 -3.264 -30.660 1.00 34.22 C \\\\nATOM 1664 CG2 ILE A 210 5.729 -4.704 -32.570 1.00 34.22 C \\\\nATOM 1665 CD1 ILE A 210 6.384 -4.344 -29.585 1.00 34.22 C \\\\nATOM 1666 N GLU A 211 5.458 -2.118 -35.229 1.00 29.47 N \\\\nATOM 1667 CA GLU A 211 4.771 -2.379 -36.491 1.00 29.47 C \\\\nATOM 1668 C GLU A 211 4.011 -3.714 -36.392 1.00 29.47 C \\\\nATOM 1669 CB GLU A 211 5.802 -2.499 -37.624 1.00 29.47 C \\\\nATOM 1670 O GLU A 211 4.579 -4.702 -35.910 1.00 29.47 O \\\\nATOM 1671 CG GLU A 211 6.550 -1.198 -37.940 1.00 29.47 C \\\\nATOM 1672 CD GLU A 211 7.571 -1.409 -39.071 1.00 29.47 C \\\\nATOM 1673 OE1 GLU A 211 7.591 -0.576 -40.002 1.00 29.47 O \\\\nATOM 1674 OE2 GLU A 211 8.328 -2.405 -38.988 1.00 29.47 O \\\\nATOM 1675 N PRO A 212 2.747 -3.800 -36.837 1.00 32.98 N \\\\nATOM 1676 CA PRO A 212 2.040 -5.065 -36.836 1.00 32.98 C \\\\nATOM 1677 C PRO A 212 2.586 -5.915 -37.986 1.00 32.98 C \\\\nATOM 1678 CB PRO A 212 0.560 -4.696 -36.957 1.00 32.98 C \\\\nATOM 1679 O PRO A 212 2.143 -5.812 -39.129 1.00 32.98 O \\\\nATOM 1680 CG PRO A 212 0.579 -3.395 -37.760 1.00 32.98 C \\\\nATOM 1681 CD PRO A 212 1.919 -2.746 -37.402 1.00 32.98 C \\\\nATOM 1682 N GLN A 213 3.550 -6.788 -37.688 1.00 33.15 N \\\\nATOM 1683 CA GLN A 213 3.832 -7.926 -38.553 1.00 33.15 C \\\\nATOM 1684 C GLN A 213 2.620 -8.861 -38.511 1.00 33.15 C \\\\nATOM 1685 CB GLN A 213 5.141 -8.631 -38.170 1.00 33.15 C \\\\nATOM 1686 O GLN A 213 2.426 -9.630 -37.572 1.00 33.15 O \\\\nATOM 1687 CG GLN A 213 6.360 -7.846 -38.680 1.00 33.15 C \\\\nATOM 1688 CD GLN A 213 7.684 -8.575 -38.463 1.00 33.15 C \\\\nATOM 1689 NE2 GLN A 213 8.735 -8.163 -39.138 1.00 33.15 N \\\\nATOM 1690 OE1 GLN A 213 7.815 -9.515 -37.695 1.00 33.15 O \\\\nATOM 1691 N SER A 214 1.776 -8.698 -39.530 1.00 28.82 N \\\\nATOM 1692 CA SER A 214 0.949 -9.711 -40.183 1.00 28.82 C \\\\nATOM 1693 C SER A 214 0.850 -11.054 -39.449 1.00 28.82 C \\\\nATOM 1694 CB SER A 214 1.532 -9.943 -41.589 1.00 28.82 C \\\\nATOM 1695 O SER A 214 1.736 -11.894 -39.588 1.00 28.82 O \\\\nATOM 1696 OG SER A 214 2.881 -10.376 -41.529 1.00 28.82 O \\\\nATOM 1697 N ASN A 215 -0.261 -11.301 -38.753 1.00 34.40 N \\\\nATOM 1698 CA ASN A 215 -0.771 -12.656 -38.568 1.00 34.40 C \\\\nATOM 1699 C ASN A 215 -2.291 -12.627 -38.360 1.00 34.40 C \\\\nATOM 1700 CB ASN A 215 -0.009 -13.410 -37.457 1.00 34.40 C \\\\nATOM 1701 O ASN A 215 -2.806 -12.058 -37.404 1.00 34.40 O \\\\nATOM 1702 CG ASN A 215 1.130 -14.267 -38.005 1.00 34.40 C \\\\nATOM 1703 ND2 ASN A 215 2.151 -14.511 -37.219 1.00 34.40 N \\\\nATOM 1704 OD1 ASN A 215 1.103 -14.773 -39.116 1.00 34.40 O \\\\nATOM 1705 N TYR A 216 -2.961 -13.225 -39.344 1.00 29.75 N \\\\nATOM 1706 CA TYR A 216 -4.365 -13.598 -39.470 1.00 29.75 C \\\\nATOM 1707 C TYR A 216 -5.182 -13.675 -38.168 1.00 29.75 C \\\\nATOM 1708 CB TYR A 216 -4.356 -14.989 -40.129 1.00 29.75 C \\\\nATOM 1709 O TYR A 216 -4.917 -14.511 -37.307 1.00 29.75 O \\\\nATOM 1710 CG TYR A 216 -4.028 -14.992 -41.611 1.00 29.75 C \\\\nATOM 1711 CD1 TYR A 216 -5.088 -15.091 -42.531 1.00 29.75 C \\\\nATOM 1712 CD2 TYR A 216 -2.697 -14.914 -42.080 1.00 29.75 C \\\\nATOM 1713 CE1 TYR A 216 -4.830 -15.108 -43.913 1.00 29.75 C \\\\nATOM 1714 CE2 TYR A 216 -2.437 -14.907 -43.466 1.00 29.75 C \\\\nATOM 1715 OH TYR A 216 -3.271 -15.017 -45.721 1.00 29.75 O \\\\nATOM 1716 CZ TYR A 216 -3.507 -15.008 -44.384 1.00 29.75 C \\\\nATOM 1717 N ILE A 217 -6.277 -12.912 -38.117 1.00 36.30 N \\\\nATOM 1718 CA ILE A 217 -7.477 -13.261 -37.345 1.00 36.30 C \\\\nATOM 1719 C ILE A 217 -8.657 -13.233 -38.337 1.00 36.30 C \\\\nATOM 1720 CB ILE A 217 -7.702 -12.323 -36.136 1.00 36.30 C \\\\nATOM 1721 O ILE A 217 -8.815 -12.221 -39.022 1.00 36.30 O \\\\nATOM 1722 CG1 ILE A 217 -6.452 -12.275 -35.225 1.00 36.30 C \\\\nATOM 1723 CG2 ILE A 217 -8.930 -12.810 -35.341 1.00 36.30 C \\\\nATOM 1724 CD1 ILE A 217 -6.571 -11.314 -34.035 1.00 36.30 C \\\\nATOM 1725 N PRO A 218 -9.443 -14.318 -38.481 1.00 32.96 N \\\\nATOM 1726 CA PRO A 218 -10.608 -14.346 -39.360 1.00 32.96 C \\\\nATOM 1727 C PRO A 218 -11.803 -13.572 -38.782 1.00 32.96 C \\\\nATOM 1728 CB PRO A 218 -10.946 -15.820 -39.605 1.00 32.96 C \\\\nATOM 1729 O PRO A 218 -11.941 -13.411 -37.572 1.00 32.96 O \\\\nATOM 1730 CG PRO A 218 -10.051 -16.621 -38.658 1.00 32.96 C \\\\nATOM 1731 CD PRO A 218 -9.295 -15.598 -37.813 1.00 32.96 C \\\\nATOM 1732 N GLU A 219 -12.654 -13.127 -39.705 1.00 30.87 N \\\\nATOM 1733 CA GLU A 219 -13.843 -12.283 -39.574 1.00 30.87 C \\\\nATOM 1734 C GLU A 219 -14.855 -12.670 -38.479 1.00 30.87 C \\\\nATOM 1735 CB GLU A 219 -14.609 -12.357 -40.910 1.00 30.87 C \\\\nATOM 1736 O GLU A 219 -15.227 -13.832 -38.327 1.00 30.87 O \\\\nATOM 1737 CG GLU A 219 -13.824 -11.896 -42.144 1.00 30.87 C \\\\nATOM 1738 CD GLU A 219 -14.698 -12.002 -43.401 1.00 30.87 C \\\\nATOM 1739 OE1 GLU A 219 -14.979 -10.943 -44.004 1.00 30.87 O \\\\nATOM 1740 OE2 GLU A 219 -15.076 -13.146 -43.743 1.00 30.87 O \\\\nATOM 1741 N THR A 220 -15.441 -11.649 -37.848 1.00 36.68 N \\\\nATOM 1742 CA THR A 220 -16.836 -11.658 -37.378 1.00 36.68 C \\\\nATOM 1743 C THR A 220 -17.442 -10.258 -37.576 1.00 36.68 C \\\\nATOM 1744 CB THR A 220 -17.000 -12.083 -35.902 1.00 36.68 C \\\\nATOM 1745 O THR A 220 -16.932 -9.297 -36.999 1.00 36.68 O \\\\nATOM 1746 CG2 THR A 220 -17.311 -13.572 -35.758 1.00 36.68 C \\\\nATOM 1747 OG1 THR A 220 -15.859 -11.832 -35.113 1.00 36.68 O \\\\nATOM 1748 N PRO A 221 -18.508 -10.089 -38.385 1.00 42.32 N \\\\nATOM 1749 CA PRO A 221 -19.201 -8.809 -38.514 1.00 42.32 C \\\\nATOM 1750 C PRO A 221 -20.236 -8.633 -37.382 1.00 42.32 C \\\\nATOM 1751 CB PRO A 221 -19.847 -8.851 -39.900 1.00 42.32 C \\\\nATOM 1752 O PRO A 221 -20.784 -9.632 -36.904 1.00 42.32 O \\\\nATOM 1753 CG PRO A 221 -20.189 -10.332 -40.078 1.00 42.32 C \\\\nATOM 1754 CD PRO A 221 -19.111 -11.072 -39.279 1.00 42.32 C \\\\nATOM 1755 N PRO A 222 -20.556 -7.399 -36.941 1.00 47.76 N \\\\nATOM 1756 CA PRO A 222 -21.640 -7.176 -35.990 1.00 47.76 C \\\\nATOM 1757 C PRO A 222 -23.023 -7.337 -36.662 1.00 47.76 C \\\\nATOM 1758 CB PRO A 222 -21.442 -5.774 -35.404 1.00 47.76 C \\\\nATOM 1759 O PRO A 222 -23.148 -7.094 -37.864 1.00 47.76 O \\\\nATOM 1760 CG PRO A 222 -20.184 -5.225 -36.082 1.00 47.76 C \\\\nATOM 1761 CD PRO A 222 -19.949 -6.129 -37.291 1.00 47.76 C \\\\nATOM 1762 N PRO A 223 -24.074 -7.726 -35.913 1.00 42.45 N \\\\nATOM 1763 CA PRO A 223 -25.353 -8.184 -36.465 1.00 42.45 C \\\\nATOM 1764 C PRO A 223 -26.228 -7.049 -37.015 1.00 42.45 C \\\\nATOM 1765 CB PRO A 223 -26.073 -8.914 -35.318 1.00 42.45 C \\\\nATOM 1766 O PRO A 223 -26.425 -6.032 -36.351 1.00 42.45 O \\\\nATOM 1767 CG PRO A 223 -25.013 -9.078 -34.231 1.00 42.45 C \\\\nATOM 1768 CD PRO A 223 -24.088 -7.897 -34.472 1.00 42.45 C \\\\nATOM 1769 N GLY A 224 -26.819 -7.264 -38.195 1.00 31.26 N \\\\nATOM 1770 CA GLY A 224 -27.895 -6.433 -38.735 1.00 31.26 C \\\\nATOM 1771 C GLY A 224 -29.232 -6.735 -38.057 1.00 31.26 C \\\\nATOM 1772 O GLY A 224 -29.611 -7.898 -37.926 1.00 31.26 O \\\\nATOM 1773 N TYR A 225 -29.949 -5.687 -37.649 1.00 42.75 N \\\\nATOM 1774 CA TYR A 225 -31.335 -5.777 -37.197 1.00 42.75 C \\\\nATOM 1775 C TYR A 225 -32.252 -5.158 -38.255 1.00 42.75 C \\\\nATOM 1776 CB TYR A 225 -31.515 -5.177 -35.793 1.00 42.75 C \\\\nATOM 1777 O TYR A 225 -32.238 -3.956 -38.508 1.00 42.75 O \\\\nATOM 1778 CG TYR A 225 -32.127 -6.155 -34.804 1.00 42.75 C \\\\nATOM 1779 CD1 TYR A 225 -33.524 -6.206 -34.627 1.00 42.75 C \\\\nATOM 1780 CD2 TYR A 225 -31.296 -7.033 -34.081 1.00 42.75 C \\\\nATOM 1781 CE1 TYR A 225 -34.087 -7.112 -33.708 1.00 42.75 C \\\\nATOM 1782 CE2 TYR A 225 -31.855 -7.941 -33.160 1.00 42.75 C \\\\nATOM 1783 OH TYR A 225 -33.792 -8.853 -32.080 1.00 42.75 O \\\\nATOM 1784 CZ TYR A 225 -33.252 -7.978 -32.969 1.00 42.75 C \\\\nATOM 1785 N ILE A 226 -32.999 -6.051 -38.888 1.00 36.55 N \\\\nATOM 1786 CA ILE A 226 -34.214 -5.839 -39.670 1.00 36.55 C \\\\nATOM 1787 C ILE A 226 -35.349 -5.370 -38.745 1.00 36.55 C \\\\nATOM 1788 CB ILE A 226 -34.596 -7.182 -40.357 1.00 36.55 C \\\\nATOM 1789 O ILE A 226 -35.517 -5.922 -37.659 1.00 36.55 O \\\\nATOM 1790 CG1 ILE A 226 -34.358 -8.412 -39.430 1.00 36.55 C \\\\nATOM 1791 CG2 ILE A 226 -33.797 -7.334 -41.664 1.00 36.55 C \\\\nATOM 1792 CD1 ILE A 226 -34.952 -9.729 -39.929 1.00 36.55 C \\\\nATOM 1793 N SER A 227 -36.143 -4.400 -39.199 1.00 47.93 N \\\\nATOM 1794 CA SER A 227 -37.483 -4.130 -38.667 1.00 47.93 C \\\\nATOM 1795 C SER A 227 -38.434 -3.907 -39.840 1.00 47.93 C \\\\nATOM 1796 CB SER A 227 -37.516 -2.924 -37.725 1.00 47.93 C \\\\nATOM 1797 O SER A 227 -38.234 -2.993 -40.640 1.00 47.93 O \\\\nATOM 1798 OG SER A 227 -36.754 -3.159 -36.553 1.00 47.93 O \\\\nATOM 1799 N GLU A 228 -39.414 -4.800 -39.935 1.00 46.11 N \\\\nATOM 1800 CA GLU A 228 -40.514 -4.858 -40.896 1.00 46.11 C \\\\nATOM 1801 C GLU A 228 -41.667 -3.894 -40.525 1.00 46.11 C \\\\nATOM 1802 CB GLU A 228 -41.021 -6.321 -40.936 1.00 46.11 C \\\\nATOM 1803 O GLU A 228 -41.901 -3.624 -39.349 1.00 46.11 O \\\\nATOM 1804 CG GLU A 228 -40.045 -7.298 -41.618 1.00 46.11 C \\\\nATOM 1805 CD GLU A 228 -40.428 -8.779 -41.415 1.00 46.11 C \\\\nATOM 1806 OE1 GLU A 228 -40.687 -9.476 -42.424 1.00 46.11 O \\\\nATOM 1807 OE2 GLU A 228 -40.337 -9.242 -40.252 1.00 46.11 O \\\\nATOM 1808 N ASP A 229 -42.363 -3.439 -41.575 1.00 43.27 N \\\\nATOM 1809 CA ASP A 229 -43.800 -3.134 -41.730 1.00 43.27 C \\\\nATOM 1810 C ASP A 229 -44.535 -2.042 -40.918 1.00 43.27 C \\\\nATOM 1811 CB ASP A 229 -44.587 -4.454 -41.742 1.00 43.27 C \\\\nATOM 1812 O ASP A 229 -44.500 -1.981 -39.691 1.00 43.27 O \\\\nATOM 1813 CG ASP A 229 -44.099 -5.419 -42.832 1.00 43.27 C \\\\nATOM 1814 OD1 ASP A 229 -43.547 -4.923 -43.845 1.00 43.27 O \\\\nATOM 1815 OD2 ASP A 229 -44.293 -6.638 -42.646 1.00 43.27 O \\\\nATOM 1816 N GLY A 230 -45.339 -1.235 -41.644 1.00 41.83 N \\\\nATOM 1817 CA GLY A 230 -46.419 -0.420 -41.058 1.00 41.83 C \\\\nATOM 1818 C GLY A 230 -46.959 0.792 -41.851 1.00 41.83 C \\\\nATOM 1819 O GLY A 230 -46.917 1.899 -41.337 1.00 41.83 O \\\\nATOM 1820 N GLU A 231 -47.436 0.576 -43.083 1.00 42.15 N \\\\nATOM 1821 CA GLU A 231 -48.653 1.121 -43.747 1.00 42.15 C \\\\nATOM 1822 C GLU A 231 -49.152 2.603 -43.629 1.00 42.15 C \\\\nATOM 1823 CB GLU A 231 -49.811 0.155 -43.417 1.00 42.15 C \\\\nATOM 1824 O GLU A 231 -49.428 3.117 -42.550 1.00 42.15 O \\\\nATOM 1825 CG GLU A 231 -49.540 -1.282 -43.904 1.00 42.15 C \\\\nATOM 1826 CD GLU A 231 -50.767 -2.196 -43.772 1.00 42.15 C \\\\nATOM 1827 OE1 GLU A 231 -51.040 -2.932 -44.747 1.00 42.15 O \\\\nATOM 1828 OE2 GLU A 231 -51.429 -2.146 -42.712 1.00 42.15 O \\\\nATOM 1829 N THR A 232 -49.529 3.161 -44.808 1.00 42.91 N \\\\nATOM 1830 CA THR A 232 -50.599 4.171 -45.128 1.00 42.91 C \\\\nATOM 1831 C THR A 232 -50.304 5.675 -44.888 1.00 42.91 C \\\\nATOM 1832 CB THR A 232 -51.949 3.746 -44.514 1.00 42.91 C \\\\nATOM 1833 O THR A 232 -49.792 6.040 -43.845 1.00 42.91 O \\\\nATOM 1834 CG2 THR A 232 -52.463 2.399 -45.036 1.00 42.91 C \\\\nATOM 1835 OG1 THR A 232 -51.949 3.754 -43.110 1.00 42.91 O \\\\nATOM 1836 N SER A 233 -50.593 6.665 -45.754 1.00 42.08 N \\\\nATOM 1837 CA SER A 233 -51.392 6.803 -46.990 1.00 42.08 C \\\\nATOM 1838 C SER A 233 -50.855 7.944 -47.882 1.00 42.08 C \\\\nATOM 1839 CB SER A 233 -52.827 7.235 -46.655 1.00 42.08 C \\\\nATOM 1840 O SER A 233 -50.367 8.956 -47.382 1.00 42.08 O \\\\nATOM 1841 OG SER A 233 -53.568 6.191 -46.074 1.00 42.08 O \\\\nATOM 1842 N ASP A 234 -51.034 7.784 -49.195 1.00 37.27 N \\\\nATOM 1843 CA ASP A 234 -50.823 8.764 -50.269 1.00 37.27 C \\\\nATOM 1844 C ASP A 234 -51.973 9.792 -50.428 1.00 37.27 C \\\\nATOM 1845 CB ASP A 234 -50.708 7.975 -51.598 1.00 37.27 C \\\\nATOM 1846 O ASP A 234 -53.094 9.568 -49.971 1.00 37.27 O \\\\nATOM 1847 CG ASP A 234 -49.301 7.534 -51.967 1.00 37.27 C \\\\nATOM 1848 OD1 ASP A 234 -48.425 8.425 -51.963 1.00 37.27 O \\\\nATOM 1849 OD2 ASP A 234 -49.159 6.359 -52.367 1.00 37.27 O \\\\nATOM 1850 N GLN A 235 -51.692 10.795 -51.282 1.00 43.07 N \\\\nATOM 1851 CA GLN A 235 -52.589 11.706 -52.035 1.00 43.07 C \\\\nATOM 1852 C GLN A 235 -52.955 13.016 -51.294 1.00 43.07 C \\\\nATOM 1853 CB GLN A 235 -53.801 10.947 -52.638 1.00 43.07 C \\\\nATOM 1854 O GLN A 235 -53.390 12.989 -50.157 1.00 43.07 O \\\\nATOM 1855 CG GLN A 235 -53.418 9.621 -53.332 1.00 43.07 C \\\\nATOM 1856 CD GLN A 235 -54.524 8.941 -54.125 1.00 43.07 C \\\\nATOM 1857 NE2 GLN A 235 -54.307 7.709 -54.536 1.00 43.07 N \\\\nATOM 1858 OE1 GLN A 235 -55.570 9.491 -54.427 1.00 43.07 O \\\\nATOM 1859 N GLN A 236 -52.828 14.231 -51.848 1.00 40.77 N \\\\nATOM 1860 CA GLN A 236 -53.079 14.661 -53.225 1.00 40.77 C \\\\nATOM 1861 C GLN A 236 -52.575 16.115 -53.450 1.00 40.77 C \\\\nATOM 1862 CB GLN A 236 -54.617 14.612 -53.409 1.00 40.77 C \\\\nATOM 1863 O GLN A 236 -52.714 16.948 -52.564 1.00 40.77 O \\\\nATOM 1864 CG GLN A 236 -55.092 14.033 -54.742 1.00 40.77 C \\\\nATOM 1865 CD GLN A 236 -56.567 13.641 -54.715 1.00 40.77 C \\\\nATOM 1866 NE2 GLN A 236 -57.005 12.779 -55.602 1.00 40.77 N \\\\nATOM 1867 OE1 GLN A 236 -57.365 14.104 -53.921 1.00 40.77 O \\\\nATOM 1868 N LEU A 237 -51.998 16.353 -54.642 1.00 40.25 N \\\\nATOM 1869 CA LEU A 237 -51.968 17.543 -55.533 1.00 40.25 C \\\\nATOM 1870 C LEU A 237 -52.324 18.968 -55.019 1.00 40.25 C \\\\nATOM 1871 CB LEU A 237 -52.972 17.219 -56.665 1.00 40.25 C \\\\nATOM 1872 O LEU A 237 -53.214 19.127 -54.205 1.00 40.25 O \\\\nATOM 1873 CG LEU A 237 -52.494 16.164 -57.685 1.00 40.25 C \\\\nATOM 1874 CD1 LEU A 237 -53.184 14.814 -57.499 1.00 40.25 C \\\\nATOM 1875 CD2 LEU A 237 -52.813 16.621 -59.108 1.00 40.25 C \\\\nATOM 1876 N ASN A 238 -51.915 20.102 -55.611 1.00 38.01 N \\\\nATOM 1877 CA ASN A 238 -50.938 20.586 -56.609 1.00 38.01 C \\\\nATOM 1878 C ASN A 238 -51.364 22.056 -56.911 1.00 38.01 C \\\\nATOM 1879 CB ASN A 238 -50.998 19.776 -57.931 1.00 38.01 C \\\\nATOM 1880 O ASN A 238 -52.565 22.311 -56.914 1.00 38.01 O \\\\nATOM 1881 CG ASN A 238 -49.783 19.919 -58.827 1.00 38.01 C \\\\nATOM 1882 ND2 ASN A 238 -49.811 19.335 -60.006 1.00 38.01 N \\\\nATOM 1883 OD1 ASN A 238 -48.781 20.517 -58.487 1.00 38.01 O \\\\nATOM 1884 N GLN A 239 -50.420 22.937 -57.292 1.00 40.11 N \\\\nATOM 1885 CA GLN A 239 -50.619 24.237 -58.001 1.00 40.11 C \\\\nATOM 1886 C GLN A 239 -51.303 25.383 -57.200 1.00 40.11 C \\\\nATOM 1887 CB GLN A 239 -51.318 23.941 -59.348 1.00 40.11 C \\\\nATOM 1888 O GLN A 239 -52.139 25.132 -56.350 1.00 40.11 O \\\\nATOM 1889 CG GLN A 239 -50.440 23.130 -60.314 1.00 40.11 C \\\\nATOM 1890 CD GLN A 239 -51.238 22.565 -61.483 1.00 40.11 C \\\\nATOM 1891 NE2 GLN A 239 -51.226 21.271 -61.713 1.00 40.11 N \\\\nATOM 1892 OE1 GLN A 239 -51.873 23.269 -62.241 1.00 40.11 O \\\\nATOM 1893 N SER A 240 -51.038 26.686 -57.365 1.00 43.35 N \\\\nATOM 1894 CA SER A 240 -50.202 27.499 -58.269 1.00 43.35 C \\\\nATOM 1895 C SER A 240 -50.144 28.959 -57.738 1.00 43.35 C \\\\nATOM 1896 CB SER A 240 -50.762 27.509 -59.706 1.00 43.35 C \\\\nATOM 1897 O SER A 240 -50.901 29.325 -56.844 1.00 43.35 O \\\\nATOM 1898 OG SER A 240 -52.158 27.305 -59.748 1.00 43.35 O \\\\nATOM 1899 N MET A 241 -49.217 29.754 -58.286 1.00 42.24 N \\\\nATOM 1900 CA MET A 241 -48.848 31.152 -57.975 1.00 42.24 C \\\\nATOM 1901 C MET A 241 -49.996 32.180 -58.075 1.00 42.24 C \\\\nATOM 1902 CB MET A 241 -47.796 31.564 -59.029 1.00 42.24 C \\\\nATOM 1903 O MET A 241 -50.863 32.002 -58.918 1.00 42.24 O \\\\nATOM 1904 CG MET A 241 -46.510 30.723 -59.019 1.00 42.24 C \\\\nATOM 1905 SD MET A 241 -45.467 30.947 -60.489 1.00 42.24 S \\\\nATOM 1906 CE MET A 241 -44.030 29.949 -60.015 1.00 42.24 C \\\\nATOM 1907 N ASP A 242 -49.936 33.283 -57.305 1.00 40.97 N \\\\nATOM 1908 CA ASP A 242 -49.971 34.649 -57.871 1.00 40.97 C \\\\nATOM 1909 C ASP A 242 -49.706 35.794 -56.863 1.00 40.97 C \\\\nATOM 1910 CB ASP A 242 -51.237 34.953 -58.711 1.00 40.97 C \\\\nATOM 1911 O ASP A 242 -49.965 35.727 -55.664 1.00 40.97 O \\\\nATOM 1912 CG ASP A 242 -51.029 34.730 -60.222 1.00 40.97 C \\\\nATOM 1913 OD1 ASP A 242 -49.864 34.851 -60.676 1.00 40.97 O \\\\nATOM 1914 OD2 ASP A 242 -52.042 34.530 -60.928 1.00 40.97 O \\\\nATOM 1915 N THR A 243 -49.128 36.839 -57.450 1.00 38.70 N \\\\nATOM 1916 CA THR A 243 -48.641 38.169 -57.038 1.00 38.70 C \\\\nATOM 1917 C THR A 243 -49.545 39.095 -56.201 1.00 38.70 C \\\\nATOM 1918 CB THR A 243 -48.421 38.931 -58.366 1.00 38.70 C \\\\nATOM 1919 O THR A 243 -50.746 39.164 -56.437 1.00 38.70 O \\\\nATOM 1920 CG2 THR A 243 -47.054 38.660 -58.985 1.00 38.70 C \\\\nATOM 1921 OG1 THR A 243 -49.362 38.545 -59.348 1.00 38.70 O \\\\nATOM 1922 N GLY A 244 -48.926 39.973 -55.383 1.00 39.50 N \\\\nATOM 1923 CA GLY A 244 -49.496 41.283 -54.995 1.00 39.50 C \\\\nATOM 1924 C GLY A 244 -49.025 41.882 -53.651 1.00 39.50 C \\\\nATOM 1925 O GLY A 244 -49.585 41.568 -52.609 1.00 39.50 O \\\\nATOM 1926 N SER A 245 -48.027 42.774 -53.675 1.00 42.65 N \\\\nATOM 1927 CA SER A 245 -47.559 43.641 -52.560 1.00 42.65 C \\\\nATOM 1928 C SER A 245 -48.484 44.872 -52.339 1.00 42.65 C \\\\nATOM 1929 CB SER A 245 -46.157 44.149 -52.950 1.00 42.65 C \\\\nATOM 1930 O SER A 245 -49.369 45.087 -53.164 1.00 42.65 O \\\\nATOM 1931 OG SER A 245 -45.287 43.109 -53.350 1.00 42.65 O \\\\nATOM 1932 N PRO A 246 -48.160 45.856 -51.462 1.00 43.21 N \\\\nATOM 1933 CA PRO A 246 -47.896 45.842 -50.010 1.00 43.21 C \\\\nATOM 1934 C PRO A 246 -48.722 46.921 -49.241 1.00 43.21 C \\\\nATOM 1935 CB PRO A 246 -46.411 46.213 -49.915 1.00 43.21 C \\\\nATOM 1936 O PRO A 246 -49.145 47.911 -49.832 1.00 43.21 O \\\\nATOM 1937 CG PRO A 246 -46.212 47.195 -51.082 1.00 43.21 C \\\\nATOM 1938 CD PRO A 246 -47.416 46.984 -52.009 1.00 43.21 C \\\\nATOM 1939 N ALA A 247 -48.870 46.811 -47.911 1.00 43.57 N \\\\nATOM 1940 CA ALA A 247 -49.324 47.925 -47.059 1.00 43.57 C \\\\nATOM 1941 C ALA A 247 -48.847 47.812 -45.588 1.00 43.57 C \\\\nATOM 1942 CB ALA A 247 -50.855 48.047 -47.127 1.00 43.57 C \\\\nATOM 1943 O ALA A 247 -49.112 46.824 -44.914 1.00 43.57 O \\\\nATOM 1944 N GLU A 248 -48.155 48.869 -45.145 1.00 39.39 N \\\\nATOM 1945 CA GLU A 248 -48.252 49.554 -43.837 1.00 39.39 C \\\\nATOM 1946 C GLU A 248 -47.778 48.893 -42.512 1.00 39.39 C \\\\nATOM 1947 CB GLU A 248 -49.618 50.255 -43.728 1.00 39.39 C \\\\nATOM 1948 O GLU A 248 -48.478 48.144 -41.844 1.00 39.39 O \\\\nATOM 1949 CG GLU A 248 -49.804 51.247 -44.896 1.00 39.39 C \\\\nATOM 1950 CD GLU A 248 -51.023 52.160 -44.732 1.00 39.39 C \\\\nATOM 1951 OE1 GLU A 248 -50.856 53.370 -45.004 1.00 39.39 O \\\\nATOM 1952 OE2 GLU A 248 -52.101 51.647 -44.362 1.00 39.39 O \\\\nATOM 1953 N LEU A 249 -46.569 49.313 -42.100 1.00 41.33 N \\\\nATOM 1954 CA LEU A 249 -46.170 49.896 -40.798 1.00 41.33 C \\\\nATOM 1955 C LEU A 249 -46.823 49.398 -39.486 1.00 41.33 C \\\\nATOM 1956 CB LEU A 249 -46.370 51.429 -40.891 1.00 41.33 C \\\\nATOM 1957 O LEU A 249 -47.955 49.752 -39.176 1.00 41.33 O \\\\nATOM 1958 CG LEU A 249 -45.467 52.162 -41.899 1.00 41.33 C \\\\nATOM 1959 CD1 LEU A 249 -46.013 53.561 -42.181 1.00 41.33 C \\\\nATOM 1960 CD2 LEU A 249 -44.037 52.303 -41.372 1.00 41.33 C \\\\nATOM 1961 N SER A 250 -46.004 48.805 -38.602 1.00 40.23 N \\\\nATOM 1962 CA SER A 250 -45.986 49.060 -37.140 1.00 40.23 C \\\\nATOM 1963 C SER A 250 -44.722 48.453 -36.493 1.00 40.23 C \\\\nATOM 1964 CB SER A 250 -47.207 48.455 -36.435 1.00 40.23 C \\\\nATOM 1965 O SER A 250 -44.469 47.267 -36.697 1.00 40.23 O \\\\nATOM 1966 OG SER A 250 -48.333 49.282 -36.627 1.00 40.23 O \\\\nATOM 1967 N PRO A 251 -43.913 49.201 -35.712 1.00 37.55 N \\\\nATOM 1968 CA PRO A 251 -42.774 48.652 -34.979 1.00 37.55 C \\\\nATOM 1969 C PRO A 251 -43.180 48.301 -33.541 1.00 37.55 C \\\\nATOM 1970 CB PRO A 251 -41.722 49.764 -35.026 1.00 37.55 C \\\\nATOM 1971 O PRO A 251 -43.771 49.122 -32.841 1.00 37.55 O \\\\nATOM 1972 CG PRO A 251 -42.560 51.046 -34.979 1.00 37.55 C \\\\nATOM 1973 CD PRO A 251 -43.921 50.653 -35.571 1.00 37.55 C \\\\nATOM 1974 N THR A 252 -42.853 47.104 -33.053 1.00 40.99 N \\\\nATOM 1975 CA THR A 252 -42.973 46.801 -31.617 1.00 40.99 C \\\\nATOM 1976 C THR A 252 -41.962 45.744 -31.171 1.00 40.99 C \\\\nATOM 1977 CB THR A 252 -44.410 46.432 -31.164 1.00 40.99 C \\\\nATOM 1978 O THR A 252 -42.014 44.586 -31.566 1.00 40.99 O \\\\nATOM 1979 CG2 THR A 252 -44.923 47.403 -30.096 1.00 40.99 C \\\\nATOM 1980 OG1 THR A 252 -45.352 46.526 -32.205 1.00 40.99 O \\\\nATOM 1981 N THR A 253 -41.062 46.204 -30.295 1.00 40.72 N \\\\nATOM 1982 CA THR A 253 -40.430 45.482 -29.175 1.00 40.72 C \\\\nATOM 1983 C THR A 253 -39.524 44.280 -29.471 1.00 40.72 C \\\\nATOM 1984 CB THR A 253 -41.461 45.163 -28.079 1.00 40.72 C \\\\nATOM 1985 O THR A 253 -39.961 43.140 -29.593 1.00 40.72 O \\\\nATOM 1986 CG2 THR A 253 -41.946 46.453 -27.410 1.00 40.72 C \\\\nATOM 1987 OG1 THR A 253 -42.597 44.519 -28.600 1.00 40.72 O \\\\nATOM 1988 N LEU A 254 -38.216 44.561 -29.424 1.00 39.36 N \\\\nATOM 1989 CA LEU A 254 -37.133 43.610 -29.166 1.00 39.36 C \\\\nATOM 1990 C LEU A 254 -37.409 42.817 -27.876 1.00 39.36 C \\\\nATOM 1991 CB LEU A 254 -35.824 44.415 -29.003 1.00 39.36 C \\\\nATOM 1992 O LEU A 254 -37.460 43.395 -26.791 1.00 39.36 O \\\\nATOM 1993 CG LEU A 254 -35.280 45.017 -30.315 1.00 39.36 C \\\\nATOM 1994 CD1 LEU A 254 -34.831 46.466 -30.117 1.00 39.36 C \\\\nATOM 1995 CD2 LEU A 254 -34.086 44.210 -30.824 1.00 39.36 C \\\\nATOM 1996 N SER A 255 -37.551 41.499 -28.001 1.00 41.25 N \\\\nATOM 1997 CA SER A 255 -37.453 40.555 -26.882 1.00 41.25 C \\\\nATOM 1998 C SER A 255 -36.006 40.052 -26.797 1.00 41.25 C \\\\nATOM 1999 CB SER A 255 -38.413 39.381 -27.082 1.00 41.25 C \\\\nATOM 2000 O SER A 255 -35.414 39.783 -27.845 1.00 41.25 O \\\\nATOM 2001 OG SER A 255 -39.740 39.860 -27.175 1.00 41.25 O \\\\nATOM 2002 N PRO A 256 -35.403 39.934 -25.602 1.00 41.93 N \\\\nATOM 2003 CA PRO A 256 -34.027 39.477 -25.476 1.00 41.93 C \\\\nATOM 2004 C PRO A 256 -33.949 37.988 -25.824 1.00 41.93 C \\\\nATOM 2005 CB PRO A 256 -33.620 39.791 -24.034 1.00 41.93 C \\\\nATOM 2006 O PRO A 256 -34.719 37.173 -25.314 1.00 41.93 O \\\\nATOM 2007 CG PRO A 256 -34.942 39.739 -23.267 1.00 41.93 C \\\\nATOM 2008 CD PRO A 256 -35.998 40.152 -24.294 1.00 41.93 C \\\\nATOM 2009 N VAL A 257 -33.012 37.640 -26.704 1.00 38.71 N \\\\nATOM 2010 CA VAL A 257 -32.677 36.258 -27.054 1.00 38.71 C \\\\nATOM 2011 C VAL A 257 -32.097 35.594 -25.803 1.00 38.71 C \\\\nATOM 2012 CB VAL A 257 -31.690 36.217 -28.246 1.00 38.71 C \\\\nATOM 2013 O VAL A 257 -30.939 35.808 -25.450 1.00 38.71 O \\\\nATOM 2014 CG1 VAL A 257 -31.494 34.785 -28.757 1.00 38.71 C \\\\nATOM 2015 CG2 VAL A 257 -32.192 37.068 -29.424 1.00 38.71 C \\\\nATOM 2016 N ASN A 258 -32.916 34.816 -25.092 1.00 38.20 N \\\\nATOM 2017 CA ASN A 258 -32.433 33.894 -24.070 1.00 38.20 C \\\\nATOM 2018 C ASN A 258 -31.664 32.778 -24.786 1.00 38.20 C \\\\nATOM 2019 CB ASN A 258 -33.611 33.347 -23.225 1.00 38.20 C \\\\nATOM 2020 O ASN A 258 -32.248 31.774 -25.190 1.00 38.20 O \\\\nATOM 2021 CG ASN A 258 -33.801 34.022 -21.876 1.00 38.20 C \\\\nATOM 2022 ND2 ASN A 258 -34.835 33.652 -21.157 1.00 38.20 N \\\\nATOM 2023 OD1 ASN A 258 -33.028 34.845 -21.420 1.00 38.20 O \\\\nATOM 2024 N HIS A 259 -30.350 32.941 -24.936 1.00 43.97 N \\\\nATOM 2025 CA HIS A 259 -29.453 31.814 -25.172 1.00 43.97 C \\\\nATOM 2026 C HIS A 259 -29.431 30.956 -23.899 1.00 43.97 C \\\\nATOM 2027 CB HIS A 259 -28.052 32.306 -25.574 1.00 43.97 C \\\\nATOM 2028 O HIS A 259 -28.532 31.072 -23.068 1.00 43.97 O \\\\nATOM 2029 CG HIS A 259 -27.983 32.894 -26.961 1.00 43.97 C \\\\nATOM 2030 CD2 HIS A 259 -27.892 34.221 -27.283 1.00 43.97 C \\\\nATOM 2031 ND1 HIS A 259 -27.951 32.189 -28.145 1.00 43.97 N \\\\nATOM 2032 CE1 HIS A 259 -27.839 33.070 -29.153 1.00 43.97 C \\\\nATOM 2033 NE2 HIS A 259 -27.810 34.324 -28.674 1.00 43.97 N \\\\nATOM 2034 N SER A 260 -30.452 30.116 -23.702 1.00 46.85 N \\\\nATOM 2035 CA SER A 260 -30.347 29.020 -22.745 1.00 46.85 C \\\\nATOM 2036 C SER A 260 -29.341 28.033 -23.325 1.00 46.85 C \\\\nATOM 2037 CB SER A 260 -31.703 28.365 -22.442 1.00 46.85 C \\\\nATOM 2038 O SER A 260 -29.677 27.256 -24.218 1.00 46.85 O \\\\nATOM 2039 OG SER A 260 -32.255 27.717 -23.567 1.00 46.85 O \\\\nATOM 2040 N LEU A 261 -28.090 28.107 -22.870 1.00 57.93 N \\\\nATOM 2041 CA LEU A 261 -27.111 27.052 -23.102 1.00 57.93 C \\\\nATOM 2042 C LEU A 261 -27.748 25.739 -22.633 1.00 57.93 C \\\\nATOM 2043 CB LEU A 261 -25.818 27.369 -22.324 1.00 57.93 C \\\\nATOM 2044 O LEU A 261 -28.035 25.584 -21.445 1.00 57.93 O \\\\nATOM 2045 CG LEU A 261 -25.012 28.555 -22.887 1.00 57.93 C \\\\nATOM 2046 CD1 LEU A 261 -23.962 29.004 -21.869 1.00 57.93 C \\\\nATOM 2047 CD2 LEU A 261 -24.291 28.181 -24.185 1.00 57.93 C \\\\nATOM 2048 N ASP A 262 -28.031 24.838 -23.573 1.00 70.10 N \\\\nATOM 2049 CA ASP A 262 -28.588 23.519 -23.283 1.00 70.10 C \\\\nATOM 2050 C ASP A 262 -27.473 22.683 -22.635 1.00 70.10 C \\\\nATOM 2051 CB ASP A 262 -29.195 22.914 -24.566 1.00 70.10 C \\\\nATOM 2052 O ASP A 262 -26.625 22.085 -23.302 1.00 70.10 O \\\\nATOM 2053 CG ASP A 262 -30.120 21.714 -24.313 1.00 70.10 C \\\\nATOM 2054 OD1 ASP A 262 -30.649 21.595 -23.187 1.00 70.10 O \\\\nATOM 2055 OD2 ASP A 262 -30.301 20.904 -25.257 1.00 70.10 O \\\\nATOM 2056 N LEU A 263 -27.388 22.779 -21.307 1.00 79.04 N \\\\nATOM 2057 CA LEU A 263 -26.398 22.100 -20.479 1.00 79.04 C \\\\nATOM 2058 C LEU A 263 -26.907 20.697 -20.144 1.00 79.04 C \\\\nATOM 2059 CB LEU A 263 -26.142 22.921 -19.199 1.00 79.04 C \\\\nATOM 2060 O LEU A 263 -27.904 20.543 -19.438 1.00 79.04 O \\\\nATOM 2061 CG LEU A 263 -25.343 24.222 -19.402 1.00 79.04 C \\\\nATOM 2062 CD1 LEU A 263 -25.410 25.078 -18.136 1.00 79.04 C \\\\nATOM 2063 CD2 LEU A 263 -23.866 23.953 -19.694 1.00 79.04 C \\\\nATOM 2064 N GLN A 264 -26.191 19.668 -20.593 1.00 82.84 N \\\\nATOM 2065 CA GLN A 264 -26.520 18.281 -20.275 1.00 82.84 C \\\\nATOM 2066 C GLN A 264 -25.827 17.858 -18.964 1.00 82.84 C \\\\nATOM 2067 CB GLN A 264 -26.128 17.375 -21.451 1.00 82.84 C \\\\nATOM 2068 O GLN A 264 -24.595 17.875 -18.900 1.00 82.84 O \\\\nATOM 2069 CG GLN A 264 -26.586 15.919 -21.255 1.00 82.84 C \\\\nATOM 2070 CD GLN A 264 -28.099 15.731 -21.323 1.00 82.84 C \\\\nATOM 2071 NE2 GLN A 264 -28.653 14.767 -20.625 1.00 82.84 N \\\\nATOM 2072 OE1 GLN A 264 -28.816 16.404 -22.041 1.00 82.84 O \\\\nATOM 2073 N PRO A 265 -26.566 17.436 -17.920 1.00 88.13 N \\\\nATOM 2074 CA PRO A 265 -25.963 16.916 -16.697 1.00 88.13 C \\\\nATOM 2075 C PRO A 265 -25.456 15.478 -16.887 1.00 88.13 C \\\\nATOM 2076 CB PRO A 265 -27.061 17.016 -15.634 1.00 88.13 C \\\\nATOM 2077 O PRO A 265 -26.204 14.589 -17.296 1.00 88.13 O \\\\nATOM 2078 CG PRO A 265 -28.351 16.862 -16.442 1.00 88.13 C \\\\nATOM 2079 CD PRO A 265 -28.015 17.515 -17.783 1.00 88.13 C \\\\nATOM 2080 N VAL A 266 -24.196 15.235 -16.522 1.00 88.49 N \\\\nATOM 2081 CA VAL A 266 -23.542 13.920 -16.544 1.00 88.49 C \\\\nATOM 2082 C VAL A 266 -23.222 13.471 -15.117 1.00 88.49 C \\\\nATOM 2083 CB VAL A 266 -22.277 13.943 -17.424 1.00 88.49 C \\\\nATOM 2084 O VAL A 266 -22.374 14.053 -14.434 1.00 88.49 O \\\\nATOM 2085 CG1 VAL A 266 -21.631 12.554 -17.454 1.00 88.49 C \\\\nATOM 2086 CG2 VAL A 266 -22.603 14.340 -18.870 1.00 88.49 C \\\\nATOM 2087 N THR A 267 -23.899 12.416 -14.658 1.00 89.40 N \\\\nATOM 2088 CA THR A 267 -23.777 11.883 -13.292 1.00 89.40 C \\\\nATOM 2089 C THR A 267 -22.712 10.789 -13.167 1.00 89.40 C \\\\nATOM 2090 CB THR A 267 -25.125 11.358 -12.769 1.00 89.40 C \\\\nATOM 2091 O THR A 267 -22.523 9.952 -14.059 1.00 89.40 O \\\\nATOM 2092 CG2 THR A 267 -26.161 12.469 -12.601 1.00 89.40 C \\\\nATOM 2093 OG1 THR A 267 -25.678 10.415 -13.657 1.00 89.40 O \\\\nATOM 2094 N TYR A 268 -22.040 10.769 -12.013 1.00 89.45 N \\\\nATOM 2095 CA TYR A 268 -21.136 9.689 -11.622 1.00 89.45 C \\\\nATOM 2096 C TYR A 268 -21.918 8.409 -11.295 1.00 89.45 C \\\\nATOM 2097 CB TYR A 268 -20.292 10.126 -10.418 1.00 89.45 C \\\\nATOM 2098 O TYR A 268 -22.978 8.457 -10.670 1.00 89.45 O \\\\nATOM 2099 CG TYR A 268 -19.250 9.105 -9.993 1.00 89.45 C \\\\nATOM 2100 CD1 TYR A 268 -19.514 8.182 -8.961 1.00 89.45 C \\\\nATOM 2101 CD2 TYR A 268 -18.001 9.084 -10.631 1.00 89.45 C \\\\nATOM 2102 CE1 TYR A 268 -18.526 7.253 -8.569 1.00 89.45 C \\\\nATOM 2103 CE2 TYR A 268 -17.000 8.186 -10.220 1.00 89.45 C \\\\nATOM 2104 OH TYR A 268 -16.280 6.389 -8.811 1.00 89.45 O \\\\nATOM 2105 CZ TYR A 268 -17.259 7.256 -9.192 1.00 89.45 C \\\\nATOM 2106 N SER A 269 -21.368 7.259 -11.680 1.00 85.81 N \\\\nATOM 2107 CA SER A 269 -21.863 5.937 -11.292 1.00 85.81 C \\\\nATOM 2108 C SER A 269 -20.695 5.073 -10.841 1.00 85.81 C \\\\nATOM 2109 CB SER A 269 -22.624 5.259 -12.439 1.00 85.81 C \\\\nATOM 2110 O SER A 269 -19.671 5.038 -11.516 1.00 85.81 O \\\\nATOM 2111 OG SER A 269 -21.890 5.242 -13.658 1.00 85.81 O \\\\nATOM 2112 N GLU A 270 -20.845 4.374 -9.718 1.00 86.25 N \\\\nATOM 2113 CA GLU A 270 -19.789 3.501 -9.206 1.00 86.25 C \\\\nATOM 2114 C GLU A 270 -19.738 2.192 -10.023 1.00 86.25 C \\\\nATOM 2115 CB GLU A 270 -20.010 3.232 -7.709 1.00 86.25 C \\\\nATOM 2116 O GLU A 270 -20.766 1.516 -10.152 1.00 86.25 O \\\\nATOM 2117 CG GLU A 270 -18.728 2.796 -6.984 1.00 86.25 C \\\\nATOM 2118 CD GLU A 270 -17.764 3.974 -6.775 1.00 86.25 C \\\\nATOM 2119 OE1 GLU A 270 -16.707 4.031 -7.432 1.00 86.25 O \\\\nATOM 2120 OE2 GLU A 270 -18.057 4.870 -5.955 1.00 86.25 O \\\\nATOM 2121 N PRO A 271 -18.581 1.815 -10.592 1.00 91.14 N \\\\nATOM 2122 CA PRO A 271 -18.441 0.578 -11.353 1.00 91.14 C \\\\nATOM 2123 C PRO A 271 -18.353 -0.655 -10.440 1.00 91.14 C \\\\nATOM 2124 CB PRO A 271 -17.169 0.768 -12.180 1.00 91.14 C \\\\nATOM 2125 O PRO A 271 -17.957 -0.569 -9.280 1.00 91.14 O \\\\nATOM 2126 CG PRO A 271 -16.321 1.650 -11.272 1.00 91.14 C \\\\nATOM 2127 CD PRO A 271 -17.340 2.574 -10.621 1.00 91.14 C \\\\nATOM 2128 N ALA A 272 -18.644 -1.837 -10.995 1.00 89.84 N \\\\nATOM 2129 CA ALA A 272 -18.530 -3.114 -10.275 1.00 89.84 C \\\\nATOM 2130 C ALA A 272 -17.092 -3.431 -9.816 1.00 89.84 C \\\\nATOM 2131 CB ALA A 272 -19.057 -4.227 -11.189 1.00 89.84 C \\\\nATOM 2132 O ALA A 272 -16.889 -4.063 -8.781 1.00 89.84 O \\\\nATOM 2133 N PHE A 273 -16.099 -2.982 -10.588 1.00 94.27 N \\\\nATOM 2134 CA PHE A 273 -14.688 -3.017 -10.220 1.00 94.27 C \\\\nATOM 2135 C PHE A 273 -14.194 -1.585 -10.114 1.00 94.27 C \\\\nATOM 2136 CB PHE A 273 -13.874 -3.797 -11.260 1.00 94.27 C \\\\nATOM 2137 O PHE A 273 -14.209 -0.868 -11.114 1.00 94.27 O \\\\nATOM 2138 CG PHE A 273 -14.326 -5.227 -11.449 1.00 94.27 C \\\\nATOM 2139 CD1 PHE A 273 -13.887 -6.225 -10.564 1.00 94.27 C \\\\nATOM 2140 CD2 PHE A 273 -15.184 -5.565 -12.512 1.00 94.27 C \\\\nATOM 2141 CE1 PHE A 273 -14.299 -7.557 -10.732 1.00 94.27 C \\\\nATOM 2142 CE2 PHE A 273 -15.603 -6.897 -12.679 1.00 94.27 C \\\\nATOM 2143 CZ PHE A 273 -15.162 -7.892 -11.790 1.00 94.27 C \\\\nATOM 2144 N TRP A 274 -13.742 -1.160 -8.939 1.00 95.07 N \\\\nATOM 2145 CA TRP A 274 -13.333 0.229 -8.720 1.00 95.07 C \\\\nATOM 2146 C TRP A 274 -11.968 0.541 -9.349 1.00 95.07 C \\\\nATOM 2147 CB TRP A 274 -13.369 0.531 -7.223 1.00 95.07 C \\\\nATOM 2148 O TRP A 274 -11.717 1.679 -9.749 1.00 95.07 O \\\\nATOM 2149 CG TRP A 274 -12.348 -0.198 -6.411 1.00 95.07 C \\\\nATOM 2150 CD1 TRP A 274 -12.518 -1.390 -5.799 1.00 95.07 C \\\\nATOM 2151 CD2 TRP A 274 -10.987 0.221 -6.105 1.00 95.07 C \\\\nATOM 2152 CE2 TRP A 274 -10.390 -0.761 -5.262 1.00 95.07 C \\\\nATOM 2153 CE3 TRP A 274 -10.209 1.350 -6.438 1.00 95.07 C \\\\nATOM 2154 NE1 TRP A 274 -11.364 -1.725 -5.122 1.00 95.07 N \\\\nATOM 2155 CH2 TRP A 274 -8.338 0.512 -5.116 1.00 95.07 C \\\\nATOM 2156 CZ2 TRP A 274 -9.095 -0.612 -4.746 1.00 95.07 C \\\\nATOM 2157 CZ3 TRP A 274 -8.892 1.487 -5.963 1.00 95.07 C \\\\nATOM 2158 N CYS A 275 -11.102 -0.468 -9.505 1.00 97.41 N \\\\nATOM 2159 CA CYS A 275 -9.862 -0.335 -10.263 1.00 97.41 C \\\\nATOM 2160 C CYS A 275 -9.446 -1.606 -11.010 1.00 97.41 C \\\\nATOM 2161 CB CYS A 275 -8.727 0.177 -9.357 1.00 97.41 C \\\\nATOM 2162 O CYS A 275 -9.892 -2.718 -10.710 1.00 97.41 O \\\\nATOM 2163 SG CYS A 275 -8.172 -1.078 -8.170 1.00 97.41 S \\\\nATOM 2164 N SER A 276 -8.544 -1.421 -11.972 1.00 97.86 N \\\\nATOM 2165 CA SER A 276 -7.793 -2.494 -12.626 1.00 97.86 C \\\\nATOM 2166 C SER A 276 -6.289 -2.268 -12.470 1.00 97.86 C \\\\nATOM 2167 CB SER A 276 -8.208 -2.627 -14.092 1.00 97.86 C \\\\nATOM 2168 O SER A 276 -5.836 -1.124 -12.540 1.00 97.86 O \\\\nATOM 2169 OG SER A 276 -7.734 -1.550 -14.869 1.00 97.86 O \\\\nATOM 2170 N ILE A 277 -5.524 -3.339 -12.253 1.00 98.47 N \\\\nATOM 2171 CA ILE A 277 -4.088 -3.291 -11.952 1.00 98.47 C \\\\nATOM 2172 C ILE A 277 -3.315 -4.126 -12.969 1.00 98.47 C \\\\nATOM 2173 CB ILE A 277 -3.763 -3.772 -10.515 1.00 98.47 C \\\\nATOM 2174 O ILE A 277 -3.540 -5.331 -13.081 1.00 98.47 O \\\\nATOM 2175 CG1 ILE A 277 -4.882 -3.422 -9.506 1.00 98.47 C \\\\nATOM 2176 CG2 ILE A 277 -2.366 -3.251 -10.127 1.00 98.47 C \\\\nATOM 2177 CD1 ILE A 277 -4.496 -3.473 -8.027 1.00 98.47 C \\\\nATOM 2178 N ALA A 278 -2.370 -3.509 -13.673 1.00 98.55 N \\\\nATOM 2179 CA ALA A 278 -1.424 -4.200 -14.544 1.00 98.55 C \\\\nATOM 2180 C ALA A 278 -0.030 -4.218 -13.905 1.00 98.55 C \\\\nATOM 2181 CB ALA A 278 -1.436 -3.533 -15.922 1.00 98.55 C \\\\nATOM 2182 O ALA A 278 0.429 -3.200 -13.390 1.00 98.55 O \\\\nATOM 2183 N TYR A 279 0.645 -5.369 -13.934 1.00 98.63 N \\\\nATOM 2184 CA TYR A 279 2.011 -5.519 -13.431 1.00 98.63 C \\\\nATOM 2185 C TYR A 279 3.033 -5.476 -14.565 1.00 98.63 C \\\\nATOM 2186 CB TYR A 279 2.130 -6.801 -12.598 1.00 98.63 C \\\\nATOM 2187 O TYR A 279 2.824 -6.041 -15.641 1.00 98.63 O \\\\nATOM 2188 CG TYR A 279 3.542 -7.114 -12.125 1.00 98.63 C \\\\nATOM 2189 CD1 TYR A 279 4.171 -8.309 -12.518 1.00 98.63 C \\\\nATOM 2190 CD2 TYR A 279 4.229 -6.208 -11.296 1.00 98.63 C \\\\nATOM 2191 CE1 TYR A 279 5.469 -8.611 -12.068 1.00 98.63 C \\\\nATOM 2192 CE2 TYR A 279 5.536 -6.493 -10.858 1.00 98.63 C \\\\nATOM 2193 OH TYR A 279 7.386 -8.020 -10.749 1.00 98.63 O \\\\nATOM 2194 CZ TYR A 279 6.152 -7.707 -11.229 1.00 98.63 C \\\\nATOM 2195 N TYR A 280 4.157 -4.820 -14.295 1.00 98.73 N \\\\nATOM 2196 CA TYR A 280 5.253 -4.645 -15.227 1.00 98.73 C \\\\nATOM 2197 C TYR A 280 6.598 -4.950 -14.563 1.00 98.73 C \\\\nATOM 2198 CB TYR A 280 5.235 -3.217 -15.775 1.00 98.73 C \\\\nATOM 2199 O TYR A 280 6.865 -4.613 -13.403 1.00 98.73 O \\\\nATOM 2200 CG TYR A 280 4.056 -2.864 -16.663 1.00 98.73 C \\\\nATOM 2201 CD1 TYR A 280 4.181 -2.933 -18.064 1.00 98.73 C \\\\nATOM 2202 CD2 TYR A 280 2.855 -2.401 -16.090 1.00 98.73 C \\\\nATOM 2203 CE1 TYR A 280 3.098 -2.569 -18.890 1.00 98.73 C \\\\nATOM 2204 CE2 TYR A 280 1.780 -2.014 -16.913 1.00 98.73 C \\\\nATOM 2205 OH TYR A 280 0.868 -1.716 -19.113 1.00 98.73 O \\\\nATOM 2206 CZ TYR A 280 1.896 -2.105 -18.315 1.00 98.73 C \\\\nATOM 2207 N GLU A 281 7.479 -5.555 -15.351 1.00 98.51 N \\\\nATOM 2208 CA GLU A 281 8.898 -5.694 -15.056 1.00 98.51 C \\\\nATOM 2209 C GLU A 281 9.661 -4.903 -16.118 1.00 98.51 C \\\\nATOM 2210 CB GLU A 281 9.305 -7.179 -15.015 1.00 98.51 C \\\\nATOM 2211 O GLU A 281 9.632 -5.253 -17.297 1.00 98.51 O \\\\nATOM 2212 CG GLU A 281 8.652 -7.916 -13.832 1.00 98.51 C \\\\nATOM 2213 CD GLU A 281 8.992 -9.413 -13.731 1.00 98.51 C \\\\nATOM 2214 OE1 GLU A 281 8.462 -10.094 -12.822 1.00 98.51 O \\\\nATOM 2215 OE2 GLU A 281 9.816 -9.955 -14.502 1.00 98.51 O \\\\nATOM 2216 N LEU A 282 10.322 -3.812 -15.716 1.00 97.97 N \\\\nATOM 2217 CA LEU A 282 10.910 -2.843 -16.646 1.00 97.97 C \\\\nATOM 2218 C LEU A 282 9.847 -2.264 -17.600 1.00 97.97 C \\\\nATOM 2219 CB LEU A 282 12.144 -3.445 -17.358 1.00 97.97 C \\\\nATOM 2220 O LEU A 282 8.870 -1.684 -17.146 1.00 97.97 O \\\\nATOM 2221 CG LEU A 282 13.223 -3.999 -16.419 1.00 97.97 C \\\\nATOM 2222 CD1 LEU A 282 14.239 -4.800 -17.230 1.00 97.97 C \\\\nATOM 2223 CD2 LEU A 282 13.966 -2.879 -15.685 1.00 97.97 C \\\\nATOM 2224 N ASN A 283 10.004 -2.398 -18.913 1.00 97.02 N \\\\nATOM 2225 CA ASN A 283 9.026 -1.967 -19.914 1.00 97.02 C \\\\nATOM 2226 C ASN A 283 8.091 -3.098 -20.380 1.00 97.02 C \\\\nATOM 2227 CB ASN A 283 9.777 -1.319 -21.090 1.00 97.02 C \\\\nATOM 2228 O ASN A 283 7.291 -2.881 -21.287 1.00 97.02 O \\\\nATOM 2229 CG ASN A 283 10.673 -2.289 -21.843 1.00 97.02 C \\\\nATOM 2230 ND2 ASN A 283 10.969 -2.008 -23.087 1.00 97.02 N \\\\nATOM 2231 OD1 ASN A 283 11.151 -3.283 -21.320 1.00 97.02 O \\\\nATOM 2232 N GLN A 284 8.187 -4.297 -19.798 1.00 97.84 N \\\\nATOM 2233 CA GLN A 284 7.410 -5.460 -20.216 1.00 97.84 C \\\\nATOM 2234 C GLN A 284 6.244 -5.708 -19.260 1.00 97.84 C \\\\nATOM 2235 CB GLN A 284 8.342 -6.674 -20.321 1.00 97.84 C \\\\nATOM 2236 O GLN A 284 6.435 -5.811 -18.048 1.00 97.84 O \\\\nATOM 2237 CG GLN A 284 7.625 -7.885 -20.934 1.00 97.84 C \\\\nATOM 2238 CD GLN A 284 8.527 -9.101 -21.097 1.00 97.84 C \\\\nATOM 2239 NE2 GLN A 284 8.044 -10.153 -21.718 1.00 97.84 N \\\\nATOM 2240 OE1 GLN A 284 9.677 -9.143 -20.691 1.00 97.84 O \\\\nATOM 2241 N ARG A 285 5.033 -5.853 -19.806 1.00 98.04 N \\\\nATOM 2242 CA ARG A 285 3.860 -6.294 -19.041 1.00 98.04 C \\\\nATOM 2243 C ARG A 285 3.996 -7.771 -18.681 1.00 98.04 C \\\\nATOM 2244 CB ARG A 285 2.586 -6.010 -19.841 1.00 98.04 C \\\\nATOM 2245 O ARG A 285 4.353 -8.586 -19.531 1.00 98.04 O \\\\nATOM 2246 CG ARG A 285 1.316 -6.279 -19.020 1.00 98.04 C \\\\nATOM 2247 CD ARG A 285 0.115 -5.771 -19.815 1.00 98.04 C \\\\nATOM 2248 NE ARG A 285 -1.167 -6.187 -19.224 1.00 98.04 N \\\\nATOM 2249 NH1 ARG A 285 -2.464 -5.493 -20.990 1.00 98.04 N \\\\nATOM 2250 NH2 ARG A 285 -3.411 -6.566 -19.315 1.00 98.04 N \\\\nATOM 2251 CZ ARG A 285 -2.332 -6.079 -19.834 1.00 98.04 C \\\\nATOM 2252 N VAL A 286 3.700 -8.113 -17.432 1.00 98.24 N \\\\nATOM 2253 CA VAL A 286 3.852 -9.466 -16.892 1.00 98.24 C \\\\nATOM 2254 C VAL A 286 2.558 -9.890 -16.201 1.00 98.24 C \\\\nATOM 2255 CB VAL A 286 5.064 -9.534 -15.940 1.00 98.24 C \\\\nATOM 2256 O VAL A 286 2.137 -9.270 -15.229 1.00 98.24 O \\\\nATOM 2257 CG1 VAL A 286 5.211 -10.922 -15.307 1.00 98.24 C \\\\nATOM 2258 CG2 VAL A 286 6.374 -9.224 -16.675 1.00 98.24 C \\\\nATOM 2259 N GLY A 287 1.964 -10.987 -16.673 1.00 96.53 N \\\\nATOM 2260 CA GLY A 287 0.712 -11.524 -16.137 1.00 96.53 C \\\\nATOM 2261 C GLY A 287 -0.550 -10.832 -16.658 1.00 96.53 C \\\\nATOM 2262 O GLY A 287 -0.506 -9.941 -17.509 1.00 96.53 O \\\\nATOM 2263 N GLU A 288 -1.691 -11.282 -16.143 1.00 95.82 N \\\\nATOM 2264 CA GLU A 288 -3.015 -10.746 -16.466 1.00 95.82 C \\\\nATOM 2265 C GLU A 288 -3.318 -9.466 -15.673 1.00 95.82 C \\\\nATOM 2266 CB GLU A 288 -4.087 -11.816 -16.208 1.00 95.82 C \\\\nATOM 2267 O GLU A 288 -2.705 -9.190 -14.639 1.00 95.82 O \\\\nATOM 2268 CG GLU A 288 -3.880 -13.061 -17.087 1.00 95.82 C \\\\nATOM 2269 CD GLU A 288 -4.966 -14.124 -16.878 1.00 95.82 C \\\\nATOM 2270 OE1 GLU A 288 -5.203 -14.883 -17.841 1.00 95.82 O \\\\nATOM 2271 OE2 GLU A 288 -5.517 -14.185 -15.757 1.00 95.82 O \\\\nATOM 2272 N THR A 289 -4.281 -8.673 -16.151 1.00 97.10 N \\\\nATOM 2273 CA THR A 289 -4.793 -7.538 -15.371 1.00 97.10 C \\\\nATOM 2274 C THR A 289 -5.664 -8.040 -14.233 1.00 97.10 C \\\\nATOM 2275 CB THR A 289 -5.594 -6.550 -16.222 1.00 97.10 C \\\\nATOM 2276 O THR A 289 -6.643 -8.753 -14.450 1.00 97.10 O \\\\nATOM 2277 CG2 THR A 289 -6.231 -5.405 -15.443 1.00 97.10 C \\\\nATOM 2278 OG1 THR A 289 -4.718 -5.889 -17.089 1.00 97.10 O \\\\nATOM 2279 N PHE A 290 -5.354 -7.596 -13.022 1.00 96.97 N \\\\nATOM 2280 CA PHE A 290 -6.176 -7.846 -11.851 1.00 96.97 C \\\\nATOM 2281 C PHE A 290 -7.320 -6.830 -11.776 1.00 96.97 C \\\\nATOM 2282 CB PHE A 290 -5.278 -7.792 -10.620 1.00 96.97 C \\\\nATOM 2283 O PHE A 290 -7.086 -5.631 -11.914 1.00 96.97 O \\\\nATOM 2284 CG PHE A 290 -5.994 -8.160 -9.344 1.00 96.97 C \\\\nATOM 2285 CD1 PHE A 290 -6.638 -7.167 -8.583 1.00 96.97 C \\\\nATOM 2286 CD2 PHE A 290 -6.019 -9.502 -8.923 1.00 96.97 C \\\\nATOM 2287 CE1 PHE A 290 -7.286 -7.513 -7.387 1.00 96.97 C \\\\nATOM 2288 CE2 PHE A 290 -6.657 -9.847 -7.721 1.00 96.97 C \\\\nATOM 2289 CZ PHE A 290 -7.279 -8.850 -6.953 1.00 96.97 C \\\\nATOM 2290 N HIS A 291 -8.545 -7.287 -11.519 1.00 96.94 N \\\\nATOM 2291 CA HIS A 291 -9.725 -6.426 -11.405 1.00 96.94 C \\\\nATOM 2292 C HIS A 291 -10.249 -6.449 -9.969 1.00 96.94 C \\\\nATOM 2293 CB HIS A 291 -10.791 -6.861 -12.416 1.00 96.94 C \\\\nATOM 2294 O HIS A 291 -10.591 -7.504 -9.439 1.00 96.94 O \\\\nATOM 2295 CG HIS A 291 -10.338 -6.727 -13.848 1.00 96.94 C \\\\nATOM 2296 CD2 HIS A 291 -10.580 -5.670 -14.683 1.00 96.94 C \\\\nATOM 2297 ND1 HIS A 291 -9.591 -7.641 -14.559 1.00 96.94 N \\\\nATOM 2298 CE1 HIS A 291 -9.403 -7.152 -15.793 1.00 96.94 C \\\\nATOM 2299 NE2 HIS A 291 -9.971 -5.943 -15.910 1.00 96.94 N \\\\nATOM 2300 N ALA A 292 -10.304 -5.281 -9.332 1.00 94.85 N \\\\nATOM 2301 CA ALA A 292 -10.612 -5.160 -7.915 1.00 94.85 C \\\\nATOM 2302 C ALA A 292 -12.092 -4.856 -7.678 1.00 94.85 C \\\\nATOM 2303 CB ALA A 292 -9.737 -4.054 -7.345 1.00 94.85 C \\\\nATOM 2304 O ALA A 292 -12.557 -3.755 -7.970 1.00 94.85 O \\\\nATOM 2305 N SER A 293 -12.831 -5.824 -7.138 1.00 91.03 N \\\\nATOM 2306 CA SER A 293 -14.233 -5.637 -6.736 1.00 91.03 C \\\\nATOM 2307 C SER A 293 -14.364 -5.249 -5.264 1.00 91.03 C \\\\nATOM 2308 CB SER A 293 -15.029 -6.910 -7.021 1.00 91.03 C \\\\nATOM 2309 O SER A 293 -15.207 -4.432 -4.909 1.00 91.03 O \\\\nATOM 2310 OG SER A 293 -14.425 -8.035 -6.398 1.00 91.03 O \\\\nATOM 2311 N GLN A 294 -13.508 -5.801 -4.401 1.00 90.62 N \\\\nATOM 2312 CA GLN A 294 -13.521 -5.508 -2.970 1.00 90.62 C \\\\nATOM 2313 C GLN A 294 -12.933 -4.120 -2.681 1.00 90.62 C \\\\nATOM 2314 CB GLN A 294 -12.771 -6.602 -2.189 1.00 90.62 C \\\\nATOM 2315 O GLN A 294 -11.941 -3.742 -3.312 1.00 90.62 O \\\\nATOM 2316 CG GLN A 294 -13.435 -7.982 -2.320 1.00 90.62 C \\\\nATOM 2317 CD GLN A 294 -14.891 -7.991 -1.863 1.00 90.62 C \\\\nATOM 2318 NE2 GLN A 294 -15.742 -8.766 -2.496 1.00 90.62 N \\\\nATOM 2319 OE1 GLN A 294 -15.304 -7.279 -0.963 1.00 90.62 O \\\\nATOM 2320 N PRO A 295 -13.460 -3.378 -1.687 1.00 89.93 N \\\\nATOM 2321 CA PRO A 295 -12.981 -2.036 -1.345 1.00 89.93 C \\\\nATOM 2322 C PRO A 295 -11.551 -2.033 -0.797 1.00 89.93 C \\\\nATOM 2323 CB PRO A 295 -13.969 -1.515 -0.295 1.00 89.93 C \\\\nATOM 2324 O PRO A 295 -10.946 -0.978 -0.670 1.00 89.93 O \\\\nATOM 2325 CG PRO A 295 -14.477 -2.789 0.379 1.00 89.93 C \\\\nATOM 2326 CD PRO A 295 -14.529 -3.779 -0.780 1.00 89.93 C \\\\nATOM 2327 N SER A 296 -10.995 -3.195 -0.456 1.00 92.89 N \\\\nATOM 2328 CA SER A 296 -9.617 -3.358 -0.006 1.00 92.89 C \\\\nATOM 2329 C SER A 296 -8.981 -4.532 -0.741 1.00 92.89 C \\\\nATOM 2330 CB SER A 296 -9.600 -3.576 1.509 1.00 92.89 C \\\\nATOM 2331 O SER A 296 -9.544 -5.622 -0.763 1.00 92.89 O \\\\nATOM 2332 OG SER A 296 -8.313 -3.961 1.962 1.00 92.89 O \\\\nATOM 2333 N LEU A 297 -7.772 -4.335 -1.261 1.00 96.06 N \\\\nATOM 2334 CA LEU A 297 -6.951 -5.391 -1.853 1.00 96.06 C \\\\nATOM 2335 C LEU A 297 -5.479 -5.222 -1.463 1.00 96.06 C \\\\nATOM 2336 CB LEU A 297 -7.161 -5.421 -3.378 1.00 96.06 C \\\\nATOM 2337 O LEU A 297 -5.037 -4.141 -1.076 1.00 96.06 O \\\\nATOM 2338 CG LEU A 297 -6.436 -4.267 -4.101 1.00 96.06 C \\\\nATOM 2339 CD1 LEU A 297 -5.200 -4.773 -4.846 1.00 96.06 C \\\\nATOM 2340 CD2 LEU A 297 -7.335 -3.596 -5.117 1.00 96.06 C \\\\nATOM 2341 N THR A 298 -4.699 -6.290 -1.571 1.00 97.78 N \\\\nATOM 2342 CA THR A 298 -3.249 -6.266 -1.349 1.00 97.78 C \\\\nATOM 2343 C THR A 298 -2.525 -6.752 -2.597 1.00 97.78 C \\\\nATOM 2344 CB THR A 298 -2.871 -7.103 -0.118 1.00 97.78 C \\\\nATOM 2345 O THR A 298 -2.809 -7.838 -3.088 1.00 97.78 O \\\\nATOM 2346 CG2 THR A 298 -1.411 -6.913 0.276 1.00 97.78 C \\\\nATOM 2347 OG1 THR A 298 -3.663 -6.707 0.989 1.00 97.78 O \\\\nATOM 2348 N VAL A 299 -1.578 -5.969 -3.109 1.00 98.41 N \\\\nATOM 2349 CA VAL A 299 -0.645 -6.407 -4.154 1.00 98.41 C \\\\nATOM 2350 C VAL A 299 0.644 -6.826 -3.462 1.00 98.41 C \\\\nATOM 2351 CB VAL A 299 -0.384 -5.311 -5.202 1.00 98.41 C \\\\nATOM 2352 O VAL A 299 1.325 -5.978 -2.886 1.00 98.41 O \\\\nATOM 2353 CG1 VAL A 299 0.448 -5.885 -6.351 1.00 98.41 C \\\\nATOM 2354 CG2 VAL A 299 -1.672 -4.700 -5.766 1.00 98.41 C \\\\nATOM 2355 N ASP A 300 0.964 -8.118 -3.477 1.00 98.33 N \\\\nATOM 2356 CA ASP A 300 2.064 -8.694 -2.697 1.00 98.33 C \\\\nATOM 2357 C ASP A 300 2.994 -9.587 -3.532 1.00 98.33 C \\\\nATOM 2358 CB ASP A 300 1.516 -9.372 -1.427 1.00 98.33 C \\\\nATOM 2359 O ASP A 300 2.729 -9.896 -4.690 1.00 98.33 O \\\\nATOM 2360 CG ASP A 300 0.725 -10.659 -1.648 1.00 98.33 C \\\\nATOM 2361 OD1 ASP A 300 1.220 -11.561 -2.354 1.00 98.33 O \\\\nATOM 2362 OD2 ASP A 300 -0.292 -10.861 -0.942 1.00 98.33 O \\\\nATOM 2363 N GLY A 301 4.136 -9.963 -2.957 1.00 97.82 N \\\\nATOM 2364 CA GLY A 301 5.156 -10.794 -3.602 1.00 97.82 C \\\\nATOM 2365 C GLY A 301 4.979 -12.297 -3.375 1.00 97.82 C \\\\nATOM 2366 O GLY A 301 5.909 -13.049 -3.660 1.00 97.82 O \\\\nATOM 2367 N PHE A 302 3.843 -12.743 -2.830 1.00 97.35 N \\\\nATOM 2368 CA PHE A 302 3.573 -14.155 -2.546 1.00 97.35 C \\\\nATOM 2369 C PHE A 302 2.885 -14.841 -3.740 1.00 97.35 C \\\\nATOM 2370 CB PHE A 302 2.783 -14.263 -1.232 1.00 97.35 C \\\\nATOM 2371 O PHE A 302 2.907 -14.325 -4.856 1.00 97.35 O \\\\nATOM 2372 CG PHE A 302 3.435 -13.594 -0.030 1.00 97.35 C \\\\nATOM 2373 CD1 PHE A 302 4.690 -14.039 0.428 1.00 97.35 C \\\\nATOM 2374 CD2 PHE A 302 2.791 -12.539 0.644 1.00 97.35 C \\\\nATOM 2375 CE1 PHE A 302 5.291 -13.437 1.547 1.00 97.35 C \\\\nATOM 2376 CE2 PHE A 302 3.385 -11.946 1.771 1.00 97.35 C \\\\nATOM 2377 CZ PHE A 302 4.638 -12.392 2.223 1.00 97.35 C \\\\nATOM 2378 N THR A 303 2.335 -16.044 -3.546 1.00 96.72 N \\\\nATOM 2379 CA THR A 303 1.984 -16.964 -4.647 1.00 96.72 C \\\\nATOM 2380 C THR A 303 0.567 -17.547 -4.562 1.00 96.72 C \\\\nATOM 2381 CB THR A 303 3.019 -18.101 -4.740 1.00 96.72 C \\\\nATOM 2382 O THR A 303 0.355 -18.666 -5.015 1.00 96.72 O \\\\nATOM 2383 CG2 THR A 303 4.447 -17.610 -4.978 1.00 96.72 C \\\\nATOM 2384 OG1 THR A 303 3.013 -18.832 -3.534 1.00 96.72 O \\\\nATOM 2385 N ASP A 304 -0.398 -16.851 -3.956 1.00 94.15 N \\\\nATOM 2386 CA ASP A 304 -1.798 -17.309 -3.915 1.00 94.15 C \\\\nATOM 2387 C ASP A 304 -2.532 -16.889 -5.205 1.00 94.15 C \\\\nATOM 2388 CB ASP A 304 -2.473 -16.747 -2.658 1.00 94.15 C \\\\nATOM 2389 O ASP A 304 -2.710 -15.693 -5.423 1.00 94.15 O \\\\nATOM 2390 CG ASP A 304 -3.936 -17.159 -2.451 1.00 94.15 C \\\\nATOM 2391 OD1 ASP A 304 -4.527 -17.856 -3.318 1.00 94.15 O \\\\nATOM 2392 OD2 ASP A 304 -4.436 -16.746 -1.375 1.00 94.15 O \\\\nATOM 2393 N PRO A 305 -2.946 -17.827 -6.077 1.00 91.29 N \\\\nATOM 2394 CA PRO A 305 -3.564 -17.491 -7.360 1.00 91.29 C \\\\nATOM 2395 C PRO A 305 -5.070 -17.204 -7.267 1.00 91.29 C \\\\nATOM 2396 CB PRO A 305 -3.296 -18.721 -8.232 1.00 91.29 C \\\\nATOM 2397 O PRO A 305 -5.663 -16.781 -8.252 1.00 91.29 O \\\\nATOM 2398 CG PRO A 305 -3.376 -19.872 -7.230 1.00 91.29 C \\\\nATOM 2399 CD PRO A 305 -2.768 -19.270 -5.965 1.00 91.29 C \\\\nATOM 2400 N SER A 306 -5.711 -17.495 -6.131 1.00 88.57 N \\\\nATOM 2401 CA SER A 306 -7.172 -17.684 -6.059 1.00 88.57 C \\\\nATOM 2402 C SER A 306 -7.919 -16.630 -5.244 1.00 88.57 C \\\\nATOM 2403 CB SER A 306 -7.461 -19.087 -5.524 1.00 88.57 C \\\\nATOM 2404 O SER A 306 -9.147 -16.650 -5.163 1.00 88.57 O \\\\nATOM 2405 OG SER A 306 -6.983 -19.271 -4.198 1.00 88.57 O \\\\nATOM 2406 N ASN A 307 -7.193 -15.712 -4.614 1.00 87.96 N \\\\nATOM 2407 CA ASN A 307 -7.768 -14.765 -3.675 1.00 87.96 C \\\\nATOM 2408 C ASN A 307 -8.130 -13.440 -4.363 1.00 87.96 C \\\\nATOM 2409 CB ASN A 307 -6.780 -14.647 -2.514 1.00 87.96 C \\\\nATOM 2410 O ASN A 307 -7.258 -12.690 -4.791 1.00 87.96 O \\\\nATOM 2411 CG ASN A 307 -7.307 -13.822 -1.365 1.00 87.96 C \\\\nATOM 2412 ND2 ASN A 307 -6.954 -14.183 -0.156 1.00 87.96 N \\\\nATOM 2413 OD1 ASN A 307 -8.048 -12.869 -1.514 1.00 87.96 O \\\\nATOM 2414 N SER A 308 -9.423 -13.110 -4.406 1.00 89.03 N \\\\nATOM 2415 CA SER A 308 -9.940 -11.878 -5.023 1.00 89.03 C \\\\nATOM 2416 C SER A 308 -9.550 -10.582 -4.298 1.00 89.03 C \\\\nATOM 2417 CB SER A 308 -11.465 -11.960 -5.118 1.00 89.03 C \\\\nATOM 2418 O SER A 308 -9.783 -9.498 -4.821 1.00 89.03 O \\\\nATOM 2419 OG SER A 308 -12.037 -12.143 -3.834 1.00 89.03 O \\\\nATOM 2420 N GLU A 309 -8.983 -10.665 -3.094 1.00 92.14 N \\\\nATOM 2421 CA GLU A 309 -8.434 -9.529 -2.341 1.00 92.14 C \\\\nATOM 2422 C GLU A 309 -6.903 -9.457 -2.441 1.00 92.14 C \\\\nATOM 2423 CB GLU A 309 -8.846 -9.615 -0.863 1.00 92.14 C \\\\nATOM 2424 O GLU A 309 -6.290 -8.568 -1.843 1.00 92.14 O \\\\nATOM 2425 CG GLU A 309 -10.360 -9.535 -0.631 1.00 92.14 C \\\\nATOM 2426 CD GLU A 309 -10.740 -9.691 0.853 1.00 92.14 C \\\\nATOM 2427 OE1 GLU A 309 -11.953 -9.833 1.122 1.00 92.14 O \\\\nATOM 2428 OE2 GLU A 309 -9.837 -9.684 1.728 1.00 92.14 O \\\\nATOM 2429 N ARG A 310 -6.252 -10.390 -3.154 1.00 96.04 N \\\\nATOM 2430 CA ARG A 310 -4.791 -10.445 -3.258 1.00 96.04 C \\\\nATOM 2431 C ARG A 310 -4.327 -10.595 -4.697 1.00 96.04 C \\\\nATOM 2432 CB ARG A 310 -4.203 -11.564 -2.396 1.00 96.04 C \\\\nATOM 2433 O ARG A 310 -4.538 -11.619 -5.333 1.00 96.04 O \\\\nATOM 2434 CG ARG A 310 -4.527 -11.394 -0.906 1.00 96.04 C \\\\nATOM 2435 CD ARG A 310 -3.942 -12.550 -0.098 1.00 96.04 C \\\\nATOM 2436 NE ARG A 310 -2.472 -12.565 -0.148 1.00 96.04 N \\\\nATOM 2437 NH1 ARG A 310 -2.160 -14.826 0.181 1.00 96.04 N \\\\nATOM 2438 NH2 ARG A 310 -0.422 -13.452 -0.107 1.00 96.04 N \\\\nATOM 2439 CZ ARG A 310 -1.701 -13.620 -0.017 1.00 96.04 C \\\\nATOM 2440 N PHE A 311 -3.589 -9.599 -5.170 1.00 97.27 N \\\\nATOM 2441 CA PHE A 311 -2.848 -9.704 -6.414 1.00 97.27 C \\\\nATOM 2442 C PHE A 311 -1.417 -10.164 -6.116 1.00 97.27 C \\\\nATOM 2443 CB PHE A 311 -2.922 -8.385 -7.183 1.00 97.27 C \\\\nATOM 2444 O PHE A 311 -0.531 -9.370 -5.791 1.00 97.27 O \\\\nATOM 2445 CG PHE A 311 -2.310 -8.407 -8.574 1.00 97.27 C \\\\nATOM 2446 CD1 PHE A 311 -1.940 -7.188 -9.172 1.00 97.27 C \\\\nATOM 2447 CD2 PHE A 311 -2.148 -9.609 -9.300 1.00 97.27 C \\\\nATOM 2448 CE1 PHE A 311 -1.416 -7.167 -10.476 1.00 97.27 C \\\\nATOM 2449 CE2 PHE A 311 -1.618 -9.587 -10.599 1.00 97.27 C \\\\nATOM 2450 CZ PHE A 311 -1.255 -8.367 -11.190 1.00 97.27 C \\\\nATOM 2451 N CYS A 312 -1.209 -11.476 -6.173 1.00 97.36 N \\\\nATOM 2452 CA CYS A 312 0.056 -12.118 -5.839 1.00 97.36 C \\\\nATOM 2453 C CYS A 312 1.023 -12.116 -7.031 1.00 97.36 C \\\\nATOM 2454 CB CYS A 312 -0.262 -13.530 -5.345 1.00 97.36 C \\\\nATOM 2455 O CYS A 312 0.951 -12.957 -7.924 1.00 97.36 O \\\\nATOM 2456 SG CYS A 312 -0.905 -13.448 -3.650 1.00 97.36 S \\\\nATOM 2457 N LEU A 313 1.981 -11.193 -7.027 1.00 97.92 N \\\\nATOM 2458 CA LEU A 313 2.961 -11.027 -8.100 1.00 97.92 C \\\\nATOM 2459 C LEU A 313 3.986 -12.164 -8.147 1.00 97.92 C \\\\nATOM 2460 CB LEU A 313 3.682 -9.679 -7.923 1.00 97.92 C \\\\nATOM 2461 O LEU A 313 4.587 -12.400 -9.197 1.00 97.92 O \\\\nATOM 2462 CG LEU A 313 2.757 -8.448 -7.849 1.00 97.92 C \\\\nATOM 2463 CD1 LEU A 313 3.620 -7.194 -7.709 1.00 97.92 C \\\\nATOM 2464 CD2 LEU A 313 1.873 -8.320 -9.087 1.00 97.92 C \\\\nATOM 2465 N GLY A 314 4.205 -12.865 -7.030 1.00 97.10 N \\\\nATOM 2466 CA GLY A 314 5.233 -13.897 -6.866 1.00 97.10 C \\\\nATOM 2467 C GLY A 314 5.062 -15.102 -7.791 1.00 97.10 C \\\\nATOM 2468 O GLY A 314 6.067 -15.654 -8.237 1.00 97.10 O \\\\nATOM 2469 N LEU A 315 3.819 -15.453 -8.143 1.00 95.97 N \\\\nATOM 2470 CA LEU A 315 3.499 -16.566 -9.051 1.00 95.97 C \\\\nATOM 2471 C LEU A 315 3.662 -16.217 -10.539 1.00 95.97 C \\\\nATOM 2472 CB LEU A 315 2.086 -17.092 -8.729 1.00 95.97 C \\\\nATOM 2473 O LEU A 315 3.755 -17.111 -11.380 1.00 95.97 O \\\\nATOM 2474 CG LEU A 315 0.935 -16.120 -9.073 1.00 95.97 C \\\\nATOM 2475 CD1 LEU A 315 0.299 -16.433 -10.426 1.00 95.97 C \\\\nATOM 2476 CD2 LEU A 315 -0.157 -16.195 -8.008 1.00 95.97 C \\\\nATOM 2477 N LEU A 316 3.706 -14.925 -10.878 1.00 96.99 N \\\\nATOM 2478 CA LEU A 316 3.794 -14.481 -12.265 1.00 96.99 C \\\\nATOM 2479 C LEU A 316 5.173 -14.805 -12.842 1.00 96.99 C \\\\nATOM 2480 CB LEU A 316 3.471 -12.984 -12.385 1.00 96.99 C \\\\nATOM 2481 O LEU A 316 6.210 -14.418 -12.291 1.00 96.99 O \\\\nATOM 2482 CG LEU A 316 2.113 -12.561 -11.798 1.00 96.99 C \\\\nATOM 2483 CD1 LEU A 316 1.944 -11.053 -11.957 1.00 96.99 C \\\\nATOM 2484 CD2 LEU A 316 0.944 -13.261 -12.490 1.00 96.99 C \\\\nATOM 2485 N SER A 317 5.184 -15.500 -13.972 1.00 96.68 N \\\\nATOM 2486 CA SER A 317 6.404 -15.879 -14.683 1.00 96.68 C \\\\nATOM 2487 C SER A 317 6.768 -14.847 -15.747 1.00 96.68 C \\\\nATOM 2488 CB SER A 317 6.244 -17.279 -15.274 1.00 96.68 C \\\\nATOM 2489 O SER A 317 5.897 -14.247 -16.368 1.00 96.68 O \\\\nATOM 2490 OG SER A 317 6.150 -18.211 -14.215 1.00 96.68 O \\\\nATOM 2491 N ASN A 318 8.068 -14.645 -15.957 1.00 96.83 N \\\\nATOM 2492 CA ASN A 318 8.603 -13.826 -17.038 1.00 96.83 C \\\\nATOM 2493 C ASN A 318 9.930 -14.436 -17.500 1.00 96.83 C \\\\nATOM 2494 CB ASN A 318 8.779 -12.374 -16.559 1.00 96.83 C \\\\nATOM 2495 O ASN A 318 10.871 -14.531 -16.712 1.00 96.83 O \\\\nATOM 2496 CG ASN A 318 9.386 -11.484 -17.632 1.00 96.83 C \\\\nATOM 2497 ND2 ASN A 318 9.829 -10.306 -17.276 1.00 96.83 N \\\\nATOM 2498 OD1 ASN A 318 9.485 -11.850 -18.793 1.00 96.83 O \\\\nATOM 2499 N VAL A 319 10.000 -14.848 -18.766 1.00 97.17 N \\\\nATOM 2500 CA VAL A 319 11.196 -15.471 -19.359 1.00 97.17 C \\\\nATOM 2501 C VAL A 319 12.351 -14.482 -19.547 1.00 97.17 C \\\\nATOM 2502 CB VAL A 319 10.863 -16.166 -20.694 1.00 97.17 C \\\\nATOM 2503 O VAL A 319 13.506 -14.891 -19.538 1.00 97.17 O \\\\nATOM 2504 CG1 VAL A 319 9.882 -17.326 -20.475 1.00 97.17 C \\\\nATOM 2505 CG2 VAL A 319 10.269 -15.208 -21.737 1.00 97.17 C \\\\nATOM 2506 N ASN A 320 12.057 -13.181 -19.638 1.00 96.50 N \\\\nATOM 2507 CA ASN A 320 13.054 -12.117 -19.802 1.00 96.50 C \\\\nATOM 2508 C ASN A 320 13.523 -11.529 -18.459 1.00 96.50 C \\\\nATOM 2509 CB ASN A 320 12.464 -11.029 -20.705 1.00 96.50 C \\\\nATOM 2510 O ASN A 320 14.186 -10.488 -18.414 1.00 96.50 O \\\\nATOM 2511 CG ASN A 320 12.086 -11.526 -22.084 1.00 96.50 C \\\\nATOM 2512 ND2 ASN A 320 11.033 -10.985 -22.645 1.00 96.50 N \\\\nATOM 2513 OD1 ASN A 320 12.723 -12.384 -22.669 1.00 96.50 O \\\\nATOM 2514 N ARG A 321 13.147 -12.154 -17.338 1.00 97.58 N \\\\nATOM 2515 CA ARG A 321 13.455 -11.652 -16.001 1.00 97.58 C \\\\nATOM 2516 C ARG A 321 14.955 -11.720 -15.729 1.00 97.58 C \\\\nATOM 2517 CB ARG A 321 12.655 -12.456 -14.978 1.00 97.58 C \\\\nATOM 2518 O ARG A 321 15.547 -12.792 -15.714 1.00 97.58 O \\\\nATOM 2519 CG ARG A 321 12.835 -11.900 -13.562 1.00 97.58 C \\\\nATOM 2520 CD ARG A 321 11.934 -12.637 -12.575 1.00 97.58 C \\\\nATOM 2521 NE ARG A 321 10.512 -12.373 -12.857 1.00 97.58 N \\\\nATOM 2522 NH1 ARG A 321 9.606 -14.398 -12.205 1.00 97.58 N \\\\nATOM 2523 NH2 ARG A 321 8.307 -12.773 -12.966 1.00 97.58 N \\\\nATOM 2524 CZ ARG A 321 9.494 -13.189 -12.681 1.00 97.58 C \\\\nATOM 2525 N ASN A 322 15.557 -10.570 -15.437 1.00 97.73 N \\\\nATOM 2526 CA ASN A 322 16.963 -10.493 -15.040 1.00 97.73 C \\\\nATOM 2527 C ASN A 322 17.152 -10.588 -13.511 1.00 97.73 C \\\\nATOM 2528 CB ASN A 322 17.599 -9.249 -15.686 1.00 97.73 C \\\\nATOM 2529 O ASN A 322 16.209 -10.436 -12.729 1.00 97.73 O \\\\nATOM 2530 CG ASN A 322 17.151 -7.924 -15.094 1.00 97.73 C \\\\nATOM 2531 ND2 ASN A 322 16.987 -6.916 -15.913 1.00 97.73 N \\\\nATOM 2532 OD1 ASN A 322 16.995 -7.756 -13.892 1.00 97.73 O \\\\nATOM 2533 N ALA A 323 18.404 -10.758 -13.075 1.00 98.07 N \\\\nATOM 2534 CA ALA A 323 18.758 -10.909 -11.661 1.00 98.07 C \\\\nATOM 2535 C ALA A 323 18.328 -9.721 -10.772 1.00 98.07 C \\\\nATOM 2536 CB ALA A 323 20.276 -11.121 -11.582 1.00 98.07 C \\\\nATOM 2537 O ALA A 323 17.970 -9.910 -9.609 1.00 98.07 O \\\\nATOM 2538 N THR A 324 18.318 -8.489 -11.304 1.00 97.78 N \\\\nATOM 2539 CA THR A 324 17.886 -7.300 -10.543 1.00 97.78 C \\\\nATOM 2540 C THR A 324 16.382 -7.333 -10.272 1.00 97.78 C \\\\nATOM 2541 CB THR A 324 18.247 -5.996 -11.274 1.00 97.78 C \\\\nATOM 2542 O THR A 324 15.947 -7.012 -9.162 1.00 97.78 O \\\\nATOM 2543 CG2 THR A 324 17.804 -4.742 -10.517 1.00 97.78 C \\\\nATOM 2544 OG1 THR A 324 19.643 -5.883 -11.404 1.00 97.78 O \\\\nATOM 2545 N VAL A 325 15.585 -7.737 -11.264 1.00 98.29 N \\\\nATOM 2546 CA VAL A 325 14.136 -7.931 -11.116 1.00 98.29 C \\\\nATOM 2547 C VAL A 325 13.861 -9.056 -10.125 1.00 98.29 C \\\\nATOM 2548 CB VAL A 325 13.481 -8.218 -12.478 1.00 98.29 C \\\\nATOM 2549 O VAL A 325 13.096 -8.871 -9.184 1.00 98.29 O \\\\nATOM 2550 CG1 VAL A 325 11.986 -8.490 -12.319 1.00 98.29 C \\\\nATOM 2551 CG2 VAL A 325 13.630 -7.049 -13.462 1.00 98.29 C \\\\nATOM 2552 N GLU A 326 14.549 -10.189 -10.255 1.00 97.74 N \\\\nATOM 2553 CA GLU A 326 14.381 -11.326 -9.349 1.00 97.74 C \\\\nATOM 2554 C GLU A 326 14.725 -10.975 -7.890 1.00 97.74 C \\\\nATOM 2555 CB GLU A 326 15.262 -12.471 -9.852 1.00 97.74 C \\\\nATOM 2556 O GLU A 326 14.016 -11.359 -6.960 1.00 97.74 O \\\\nATOM 2557 CG GLU A 326 14.721 -13.828 -9.395 1.00 97.74 C \\\\nATOM 2558 CD GLU A 326 15.759 -14.933 -9.594 1.00 97.74 C \\\\nATOM 2559 OE1 GLU A 326 15.776 -15.832 -8.727 1.00 97.74 O \\\\nATOM 2560 OE2 GLU A 326 16.610 -14.789 -10.490 1.00 97.74 O \\\\nATOM 2561 N MET A 327 15.794 -10.209 -7.659 1.00 97.59 N \\\\nATOM 2562 CA MET A 327 16.147 -9.710 -6.327 1.00 97.59 C \\\\nATOM 2563 C MET A 327 15.103 -8.722 -5.792 1.00 97.59 C \\\\nATOM 2564 CB MET A 327 17.539 -9.070 -6.389 1.00 97.59 C \\\\nATOM 2565 O MET A 327 14.763 -8.762 -4.611 1.00 97.59 O \\\\nATOM 2566 CG MET A 327 18.035 -8.631 -5.006 1.00 97.59 C \\\\nATOM 2567 SD MET A 327 19.672 -7.856 -5.020 1.00 97.59 S \\\\nATOM 2568 CE MET A 327 20.725 -9.310 -5.290 1.00 97.59 C \\\\nATOM 2569 N THR A 328 14.567 -7.855 -6.653 1.00 98.24 N \\\\nATOM 2570 CA THR A 328 13.542 -6.872 -6.271 1.00 98.24 C \\\\nATOM 2571 C THR A 328 12.232 -7.556 -5.877 1.00 98.24 C \\\\nATOM 2572 CB THR A 328 13.318 -5.853 -7.398 1.00 98.24 C \\\\nATOM 2573 O THR A 328 11.670 -7.224 -4.836 1.00 98.24 O \\\\nATOM 2574 CG2 THR A 328 12.306 -4.781 -7.010 1.00 98.24 C \\\\nATOM 2575 OG1 THR A 328 14.542 -5.197 -7.673 1.00 98.24 O \\\\nATOM 2576 N ARG A 329 11.798 -8.577 -6.628 1.00 98.35 N \\\\nATOM 2577 CA ARG A 329 10.590 -9.370 -6.335 1.00 98.35 C \\\\nATOM 2578 C ARG A 329 10.609 -9.990 -4.937 1.00 98.35 C \\\\nATOM 2579 CB ARG A 329 10.412 -10.460 -7.402 1.00 98.35 C \\\\nATOM 2580 O ARG A 329 9.590 -9.963 -4.254 1.00 98.35 O \\\\nATOM 2581 CG ARG A 329 9.955 -9.872 -8.744 1.00 98.35 C \\\\nATOM 2582 CD ARG A 329 10.008 -10.903 -9.872 1.00 98.35 C \\\\nATOM 2583 NE ARG A 329 9.130 -12.058 -9.617 1.00 98.35 N \\\\nATOM 2584 NH1 ARG A 329 7.139 -11.118 -10.318 1.00 98.35 N \\\\nATOM 2585 NH2 ARG A 329 7.166 -13.166 -9.480 1.00 98.35 N \\\\nATOM 2586 CZ ARG A 329 7.825 -12.099 -9.806 1.00 98.35 C \\\\nATOM 2587 N ARG A 330 11.773 -10.465 -4.472 1.00 97.77 N \\\\nATOM 2588 CA ARG A 330 11.949 -11.017 -3.111 1.00 97.77 C \\\\nATOM 2589 C ARG A 330 11.653 -10.000 -2.003 1.00 97.77 C \\\\nATOM 2590 CB ARG A 330 13.377 -11.557 -2.929 1.00 97.77 C \\\\nATOM 2591 O ARG A 330 11.192 -10.388 -0.938 1.00 97.77 O \\\\nATOM 2592 CG ARG A 330 13.676 -12.800 -3.778 1.00 97.77 C \\\\nATOM 2593 CD ARG A 330 15.146 -13.199 -3.598 1.00 97.77 C \\\\nATOM 2594 NE ARG A 330 15.505 -14.389 -4.391 1.00 97.77 N \\\\nATOM 2595 NH1 ARG A 330 16.166 -13.356 -6.344 1.00 97.77 N \\\\nATOM 2596 NH2 ARG A 330 16.360 -15.551 -6.138 1.00 97.77 N \\\\nATOM 2597 CZ ARG A 330 16.011 -14.419 -5.612 1.00 97.77 C \\\\nATOM 2598 N HIS A 331 11.891 -8.714 -2.261 1.00 97.91 N \\\\nATOM 2599 CA HIS A 331 11.701 -7.631 -1.292 1.00 97.91 C \\\\nATOM 2600 C HIS A 331 10.309 -6.993 -1.356 1.00 97.91 C \\\\nATOM 2601 CB HIS A 331 12.799 -6.580 -1.485 1.00 97.91 C \\\\nATOM 2602 O HIS A 331 9.998 -6.134 -0.536 1.00 97.91 O \\\\nATOM 2603 CG HIS A 331 14.171 -7.075 -1.124 1.00 97.91 C \\\\nATOM 2604 CD2 HIS A 331 14.804 -6.915 0.079 1.00 97.91 C \\\\nATOM 2605 ND1 HIS A 331 15.028 -7.762 -1.952 1.00 97.91 N \\\\nATOM 2606 CE1 HIS A 331 16.153 -8.011 -1.265 1.00 97.91 C \\\\nATOM 2607 NE2 HIS A 331 16.067 -7.506 -0.028 1.00 97.91 N \\\\nATOM 2608 N ILE A 332 9.444 -7.410 -2.291 1.00 98.33 N \\\\nATOM 2609 CA ILE A 332 8.044 -6.968 -2.289 1.00 98.33 C \\\\nATOM 2610 C ILE A 332 7.382 -7.439 -0.989 1.00 98.33 C \\\\nATOM 2611 CB ILE A 332 7.289 -7.454 -3.548 1.00 98.33 C \\\\nATOM 2612 O ILE A 332 6.767 -6.633 -0.291 1.00 98.33 O \\\\nATOM 2613 CG1 ILE A 332 7.951 -6.868 -4.816 1.00 98.33 C \\\\nATOM 2614 CG2 ILE A 332 5.803 -7.051 -3.477 1.00 98.33 C \\\\nATOM 2615 CD1 ILE A 332 7.322 -7.321 -6.138 1.00 98.33 C \\\\nATOM 2616 N GLY A 333 7.564 -8.710 -0.613 1.00 96.97 N \\\\nATOM 2617 CA GLY A 333 7.011 -9.267 0.622 1.00 96.97 C \\\\nATOM 2618 C GLY A 333 5.499 -9.059 0.688 1.00 96.97 C \\\\nATOM 2619 O GLY A 333 4.781 -9.431 -0.234 1.00 96.97 O \\\\nATOM 2620 N ARG A 334 5.014 -8.404 1.747 1.00 96.99 N \\\\nATOM 2621 CA ARG A 334 3.590 -8.052 1.914 1.00 96.99 C \\\\nATOM 2622 C ARG A 334 3.105 -6.923 0.990 1.00 96.99 C \\\\nATOM 2623 CB ARG A 334 3.332 -7.682 3.376 1.00 96.99 C \\\\nATOM 2624 O ARG A 334 1.907 -6.669 0.949 1.00 96.99 O \\\\nATOM 2625 CG ARG A 334 3.610 -8.820 4.371 1.00 96.99 C \\\\nATOM 2626 CD ARG A 334 3.509 -8.312 5.813 1.00 96.99 C \\\\nATOM 2627 NE ARG A 334 2.156 -7.801 6.116 1.00 96.99 N \\\\nATOM 2628 NH1 ARG A 334 2.778 -6.270 7.713 1.00 96.99 N \\\\nATOM 2629 NH2 ARG A 334 0.650 -6.379 7.050 1.00 96.99 N \\\\nATOM 2630 CZ ARG A 334 1.871 -6.829 6.963 1.00 96.99 C \\\\nATOM 2631 N GLY A 335 4.019 -6.256 0.284 1.00 97.95 N \\\\nATOM 2632 CA GLY A 335 3.738 -5.303 -0.786 1.00 97.95 C \\\\nATOM 2633 C GLY A 335 2.956 -4.063 -0.355 1.00 97.95 C \\\\nATOM 2634 O GLY A 335 3.332 -3.387 0.604 1.00 97.95 O \\\\nATOM 2635 N VAL A 336 1.898 -3.735 -1.094 1.00 98.47 N \\\\nATOM 2636 CA VAL A 336 1.054 -2.552 -0.872 1.00 98.47 C \\\\nATOM 2637 C VAL A 336 -0.393 -2.973 -0.664 1.00 98.47 C \\\\nATOM 2638 CB VAL A 336 1.204 -1.522 -2.012 1.00 98.47 C \\\\nATOM 2639 O VAL A 336 -0.916 -3.807 -1.401 1.00 98.47 O \\\\nATOM 2640 CG1 VAL A 336 0.789 -2.047 -3.392 1.00 98.47 C \\\\nATOM 2641 CG2 VAL A 336 0.412 -0.237 -1.741 1.00 98.47 C \\\\nATOM 2642 N ARG A 337 -1.062 -2.375 0.322 1.00 97.58 N \\\\nATOM 2643 CA ARG A 337 -2.518 -2.443 0.435 1.00 97.58 C \\\\nATOM 2644 C ARG A 337 -3.132 -1.201 -0.182 1.00 97.58 C \\\\nATOM 2645 CB ARG A 337 -2.931 -2.656 1.887 1.00 97.58 C \\\\nATOM 2646 O ARG A 337 -2.751 -0.086 0.167 1.00 97.58 O \\\\nATOM 2647 CG ARG A 337 -4.458 -2.695 2.038 1.00 97.58 C \\\\nATOM 2648 CD ARG A 337 -4.849 -2.850 3.499 1.00 97.58 C \\\\nATOM 2649 NE ARG A 337 -4.440 -4.165 4.015 1.00 97.58 N \\\\nATOM 2650 NH1 ARG A 337 -4.005 -3.476 6.154 1.00 97.58 N \\\\nATOM 2651 NH2 ARG A 337 -4.062 -5.673 5.649 1.00 97.58 N \\\\nATOM 2652 CZ ARG A 337 -4.166 -4.427 5.272 1.00 97.58 C \\\\nATOM 2653 N LEU A 338 -4.098 -1.415 -1.063 1.00 97.59 N \\\\nATOM 2654 CA LEU A 338 -4.912 -0.367 -1.655 1.00 97.59 C \\\\nATOM 2655 C LEU A 338 -6.320 -0.481 -1.098 1.00 97.59 C \\\\nATOM 2656 CB LEU A 338 -4.897 -0.468 -3.187 1.00 97.59 C \\\\nATOM 2657 O LEU A 338 -6.879 -1.579 -1.059 1.00 97.59 O \\\\nATOM 2658 CG LEU A 338 -3.497 -0.423 -3.817 1.00 97.59 C \\\\nATOM 2659 CD1 LEU A 338 -3.606 -0.648 -5.321 1.00 97.59 C \\\\nATOM 2660 CD2 LEU A 338 -2.817 0.921 -3.570 1.00 97.59 C \\\\nATOM 2661 N TYR A 339 -6.886 0.635 -0.657 1.00 94.29 N \\\\nATOM 2662 CA TYR A 339 -8.265 0.657 -0.192 1.00 94.29 C \\\\nATOM 2663 C TYR A 339 -9.008 1.896 -0.686 1.00 94.29 C \\\\nATOM 2664 CB TYR A 339 -8.335 0.456 1.329 1.00 94.29 C \\\\nATOM 2665 O TYR A 339 -8.458 2.998 -0.687 1.00 94.29 O \\\\nATOM 2666 CG TYR A 339 -7.543 1.443 2.169 1.00 94.29 C \\\\nATOM 2667 CD1 TYR A 339 -6.210 1.165 2.529 1.00 94.29 C \\\\nATOM 2668 CD2 TYR A 339 -8.145 2.635 2.605 1.00 94.29 C \\\\nATOM 2669 CE1 TYR A 339 -5.487 2.074 3.325 1.00 94.29 C \\\\nATOM 2670 CE2 TYR A 339 -7.443 3.529 3.435 1.00 94.29 C \\\\nATOM 2671 OH TYR A 339 -5.372 4.184 4.461 1.00 94.29 O \\\\nATOM 2672 CZ TYR A 339 -6.099 3.260 3.778 1.00 94.29 C \\\\nATOM 2673 N TYR A 340 -10.252 1.677 -1.109 1.00 94.08 N \\\\nATOM 2674 CA TYR A 340 -11.198 2.666 -1.603 1.00 94.08 C \\\\nATOM 2675 C TYR A 340 -12.298 2.883 -0.566 1.00 94.08 C \\\\nATOM 2676 CB TYR A 340 -11.787 2.203 -2.940 1.00 94.08 C \\\\nATOM 2677 O TYR A 340 -13.059 1.967 -0.251 1.00 94.08 O \\\\nATOM 2678 CG TYR A 340 -12.829 3.157 -3.495 1.00 94.08 C \\\\nATOM 2679 CD1 TYR A 340 -14.131 2.706 -3.792 1.00 94.08 C \\\\nATOM 2680 CD2 TYR A 340 -12.493 4.507 -3.719 1.00 94.08 C \\\\nATOM 2681 CE1 TYR A 340 -15.084 3.595 -4.329 1.00 94.08 C \\\\nATOM 2682 CE2 TYR A 340 -13.440 5.394 -4.262 1.00 94.08 C \\\\nATOM 2683 OH TYR A 340 -15.648 5.811 -5.089 1.00 94.08 O \\\\nATOM 2684 CZ TYR A 340 -14.740 4.941 -4.572 1.00 94.08 C \\\\nATOM 2685 N ILE A 341 -12.338 4.078 0.021 1.00 89.81 N \\\\nATOM 2686 CA ILE A 341 -13.234 4.410 1.131 1.00 89.81 C \\\\nATOM 2687 C ILE A 341 -13.700 5.849 0.976 1.00 89.81 C \\\\nATOM 2688 CB ILE A 341 -12.529 4.199 2.489 1.00 89.81 C \\\\nATOM 2689 O ILE A 341 -12.882 6.758 0.866 1.00 89.81 O \\\\nATOM 2690 CG1 ILE A 341 -12.080 2.726 2.624 1.00 89.81 C \\\\nATOM 2691 CG2 ILE A 341 -13.460 4.596 3.652 1.00 89.81 C \\\\nATOM 2692 CD1 ILE A 341 -11.307 2.440 3.893 1.00 89.81 C \\\\nATOM 2693 N GLY A 342 -15.016 6.063 0.993 1.00 86.14 N \\\\nATOM 2694 CA GLY A 342 -15.597 7.405 0.992 1.00 86.14 C \\\\nATOM 2695 C GLY A 342 -15.259 8.241 -0.249 1.00 86.14 C \\\\nATOM 2696 O GLY A 342 -15.158 9.458 -0.142 1.00 86.14 O \\\\nATOM 2697 N GLY A 343 -15.028 7.616 -1.409 1.00 91.06 N \\\\nATOM 2698 CA GLY A 343 -14.581 8.324 -2.616 1.00 91.06 C \\\\nATOM 2699 C GLY A 343 -13.084 8.656 -2.634 1.00 91.06 C \\\\nATOM 2700 O GLY A 343 -12.636 9.430 -3.477 1.00 91.06 O \\\\nATOM 2701 N GLU A 344 -12.297 8.093 -1.718 1.00 95.31 N \\\\nATOM 2702 CA GLU A 344 -10.852 8.298 -1.624 1.00 95.31 C \\\\nATOM 2703 C GLU A 344 -10.106 6.972 -1.770 1.00 95.31 C \\\\nATOM 2704 CB GLU A 344 -10.482 8.970 -0.295 1.00 95.31 C \\\\nATOM 2705 O GLU A 344 -10.546 5.940 -1.260 1.00 95.31 O \\\\nATOM 2706 CG GLU A 344 -11.302 10.232 -0.002 1.00 95.31 C \\\\nATOM 2707 CD GLU A 344 -10.703 11.044 1.148 1.00 95.31 C \\\\nATOM 2708 OE1 GLU A 344 -10.492 12.263 0.951 1.00 95.31 O \\\\nATOM 2709 OE2 GLU A 344 -10.289 10.495 2.196 1.00 95.31 O \\\\nATOM 2710 N VAL A 345 -8.951 6.998 -2.437 1.00 97.02 N \\\\nATOM 2711 CA VAL A 345 -8.064 5.834 -2.562 1.00 97.02 C \\\\nATOM 2712 C VAL A 345 -6.793 6.093 -1.773 1.00 97.02 C \\\\nATOM 2713 CB VAL A 345 -7.734 5.471 -4.021 1.00 97.02 C \\\\nATOM 2714 O VAL A 345 -6.159 7.145 -1.907 1.00 97.02 O \\\\nATOM 2715 CG1 VAL A 345 -6.968 4.143 -4.103 1.00 97.02 C \\\\nATOM 2716 CG2 VAL A 345 -8.986 5.315 -4.892 1.00 97.02 C \\\\nATOM 2717 N PHE A 346 -6.380 5.106 -0.989 1.00 97.07 N \\\\nATOM 2718 CA PHE A 346 -5.151 5.148 -0.209 1.00 97.07 C \\\\nATOM 2719 C PHE A 346 -4.224 3.991 -0.574 1.00 97.07 C \\\\nATOM 2720 CB PHE A 346 -5.493 5.078 1.271 1.00 97.07 C \\\\nATOM 2721 O PHE A 346 -4.683 2.895 -0.893 1.00 97.07 O \\\\nATOM 2722 CG PHE A 346 -6.297 6.235 1.835 1.00 97.07 C \\\\nATOM 2723 CD1 PHE A 346 -5.655 7.239 2.584 1.00 97.07 C \\\\nATOM 2724 CD2 PHE A 346 -7.695 6.276 1.669 1.00 97.07 C \\\\nATOM 2725 CE1 PHE A 346 -6.405 8.281 3.159 1.00 97.07 C \\\\nATOM 2726 CE2 PHE A 346 -8.443 7.312 2.250 1.00 97.07 C \\\\nATOM 2727 CZ PHE A 346 -7.800 8.318 2.989 1.00 97.07 C \\\\nATOM 2728 N ALA A 347 -2.919 4.234 -0.463 1.00 97.96 N \\\\nATOM 2729 CA ALA A 347 -1.883 3.211 -0.516 1.00 97.96 C \\\\nATOM 2730 C ALA A 347 -1.181 3.105 0.840 1.00 97.96 C \\\\nATOM 2731 CB ALA A 347 -0.893 3.540 -1.640 1.00 97.96 C \\\\nATOM 2732 O ALA A 347 -0.631 4.091 1.324 1.00 97.96 O \\\\nATOM 2733 N GLU A 348 -1.175 1.913 1.434 1.00 97.60 N \\\\nATOM 2734 CA GLU A 348 -0.460 1.568 2.668 1.00 97.60 C \\\\nATOM 2735 C GLU A 348 0.707 0.628 2.335 1.00 97.60 C \\\\nATOM 2736 CB GLU A 348 -1.450 0.952 3.679 1.00 97.60 C \\\\nATOM 2737 O GLU A 348 0.514 -0.455 1.775 1.00 97.60 O \\\\nATOM 2738 CG GLU A 348 -0.813 0.537 5.019 1.00 97.60 C \\\\nATOM 2739 CD GLU A 348 -1.741 -0.274 5.959 1.00 97.60 C \\\\nATOM 2740 OE1 GLU A 348 -1.431 -0.329 7.170 1.00 97.60 O \\\\nATOM 2741 OE2 GLU A 348 -2.691 -0.964 5.499 1.00 97.60 O \\\\nATOM 2742 N CYS A 349 1.932 1.025 2.684 1.00 97.68 N \\\\nATOM 2743 CA CYS A 349 3.120 0.208 2.464 1.00 97.68 C \\\\nATOM 2744 C CYS A 349 3.221 -0.877 3.542 1.00 97.68 C \\\\nATOM 2745 CB CYS A 349 4.354 1.110 2.436 1.00 97.68 C \\\\nATOM 2746 O CYS A 349 3.591 -0.606 4.685 1.00 97.68 O \\\\nATOM 2747 SG CYS A 349 5.812 0.141 1.956 1.00 97.68 S \\\\nATOM 2748 N LEU A 350 2.915 -2.121 3.168 1.00 97.08 N \\\\nATOM 2749 CA LEU A 350 3.031 -3.288 4.046 1.00 97.08 C \\\\nATOM 2750 C LEU A 350 4.384 -3.999 3.924 1.00 97.08 C \\\\nATOM 2751 CB LEU A 350 1.897 -4.273 3.731 1.00 97.08 C \\\\nATOM 2752 O LEU A 350 4.718 -4.808 4.790 1.00 97.08 O \\\\nATOM 2753 CG LEU A 350 0.470 -3.734 3.912 1.00 97.08 C \\\\nATOM 2754 CD1 LEU A 350 -0.500 -4.899 3.700 1.00 97.08 C \\\\nATOM 2755 CD2 LEU A 350 0.237 -3.171 5.314 1.00 97.08 C \\\\nATOM 2756 N SER A 351 5.112 -3.742 2.837 1.00 97.55 N \\\\nATOM 2757 CA SER A 351 6.471 -4.219 2.599 1.00 97.55 C \\\\nATOM 2758 C SER A 351 7.459 -3.616 3.600 1.00 97.55 C \\\\nATOM 2759 CB SER A 351 6.889 -3.842 1.174 1.00 97.55 C \\\\nATOM 2760 O SER A 351 7.312 -2.464 4.008 1.00 97.55 O \\\\nATOM 2761 OG SER A 351 8.183 -4.338 0.888 1.00 97.55 O \\\\nATOM 2762 N ASP A 352 8.506 -4.376 3.928 1.00 97.73 N \\\\nATOM 2763 CA ASP A 352 9.672 -3.889 4.679 1.00 97.73 C \\\\nATOM 2764 C ASP A 352 10.552 -2.948 3.829 1.00 97.73 C \\\\nATOM 2765 CB ASP A 352 10.497 -5.086 5.177 1.00 97.73 C \\\\nATOM 2766 O ASP A 352 11.463 -2.295 4.335 1.00 97.73 O \\\\nATOM 2767 CG ASP A 352 9.687 -6.060 6.040 1.00 97.73 C \\\\nATOM 2768 OD1 ASP A 352 8.900 -5.590 6.891 1.00 97.73 O \\\\nATOM 2769 OD2 ASP A 352 9.822 -7.280 5.800 1.00 97.73 O \\\\nATOM 2770 N SER A 353 10.281 -2.861 2.523 1.00 97.87 N \\\\nATOM 2771 CA SER A 353 10.881 -1.908 1.590 1.00 97.87 C \\\\nATOM 2772 C SER A 353 9.872 -0.838 1.176 1.00 97.87 C \\\\nATOM 2773 CB SER A 353 11.387 -2.646 0.355 1.00 97.87 C \\\\nATOM 2774 O SER A 353 8.687 -1.110 1.029 1.00 97.87 O \\\\nATOM 2775 OG SER A 353 12.472 -3.474 0.711 1.00 97.87 O \\\\nATOM 2776 N ALA A 354 10.346 0.386 0.938 1.00 98.19 N \\\\nATOM 2777 CA ALA A 354 9.480 1.481 0.503 1.00 98.19 C \\\\nATOM 2778 C ALA A 354 8.854 1.226 -0.880 1.00 98.19 C \\\\nATOM 2779 CB ALA A 354 10.281 2.789 0.517 1.00 98.19 C \\\\nATOM 2780 O ALA A 354 9.454 0.578 -1.746 1.00 98.19 O \\\\nATOM 2781 N ILE A 355 7.686 1.826 -1.100 1.00 98.61 N \\\\nATOM 2782 CA ILE A 355 7.050 1.953 -2.416 1.00 98.61 C \\\\nATOM 2783 C ILE A 355 7.110 3.408 -2.884 1.00 98.61 C \\\\nATOM 2784 CB ILE A 355 5.617 1.375 -2.426 1.00 98.61 C \\\\nATOM 2785 O ILE A 355 7.277 4.332 -2.086 1.00 98.61 O \\\\nATOM 2786 CG1 ILE A 355 4.688 2.175 -1.494 1.00 98.61 C \\\\nATOM 2787 CG2 ILE A 355 5.653 -0.123 -2.075 1.00 98.61 C \\\\nATOM 2788 CD1 ILE A 355 3.241 1.685 -1.442 1.00 98.61 C \\\\nATOM 2789 N PHE A 356 6.994 3.616 -4.188 1.00 98.53 N \\\\nATOM 2790 CA PHE A 356 7.125 4.925 -4.823 1.00 98.53 C \\\\nATOM 2791 C PHE A 356 5.921 5.140 -5.721 1.00 98.53 C \\\\nATOM 2792 CB PHE A 356 8.440 4.970 -5.608 1.00 98.53 C \\\\nATOM 2793 O PHE A 356 5.652 4.287 -6.556 1.00 98.53 O \\\\nATOM 2794 CG PHE A 356 9.661 4.735 -4.752 1.00 98.53 C \\\\nATOM 2795 CD1 PHE A 356 10.376 5.816 -4.206 1.00 98.53 C \\\\nATOM 2796 CD2 PHE A 356 10.061 3.416 -4.470 1.00 98.53 C \\\\nATOM 2797 CE1 PHE A 356 11.488 5.562 -3.384 1.00 98.53 C \\\\nATOM 2798 CE2 PHE A 356 11.152 3.175 -3.623 1.00 98.53 C \\\\nATOM 2799 CZ PHE A 356 11.881 4.248 -3.096 1.00 98.53 C \\\\nATOM 2800 N VAL A 357 5.184 6.229 -5.533 1.00 98.21 N \\\\nATOM 2801 CA VAL A 357 3.879 6.458 -6.159 1.00 98.21 C \\\\nATOM 2802 C VAL A 357 3.912 7.739 -6.975 1.00 98.21 C \\\\nATOM 2803 CB VAL A 357 2.761 6.519 -5.101 1.00 98.21 C \\\\nATOM 2804 O VAL A 357 4.269 8.792 -6.458 1.00 98.21 O \\\\nATOM 2805 CG1 VAL A 357 1.389 6.733 -5.755 1.00 98.21 C \\\\nATOM 2806 CG2 VAL A 357 2.726 5.232 -4.262 1.00 98.21 C \\\\nATOM 2807 N GLN A 358 3.482 7.661 -8.228 1.00 98.17 N \\\\nATOM 2808 CA GLN A 358 3.169 8.813 -9.064 1.00 98.17 C \\\\nATOM 2809 C GLN A 358 1.657 8.841 -9.264 1.00 98.17 C \\\\nATOM 2810 CB GLN A 358 3.941 8.699 -10.381 1.00 98.17 C \\\\nATOM 2811 O GLN A 358 1.110 8.033 -10.017 1.00 98.17 O \\\\nATOM 2812 CG GLN A 358 3.722 9.881 -11.334 1.00 98.17 C \\\\nATOM 2813 CD GLN A 358 4.458 9.662 -12.654 1.00 98.17 C \\\\nATOM 2814 NE2 GLN A 358 5.532 10.379 -12.912 1.00 98.17 N \\\\nATOM 2815 OE1 GLN A 358 4.105 8.810 -13.458 1.00 98.17 O \\\\nATOM 2816 N SER A 359 0.989 9.755 -8.561 1.00 97.96 N \\\\nATOM 2817 CA SER A 359 -0.434 10.039 -8.743 1.00 97.96 C \\\\nATOM 2818 C SER A 359 -0.601 11.513 -9.107 1.00 97.96 C \\\\nATOM 2819 CB SER A 359 -1.239 9.712 -7.487 1.00 97.96 C \\\\nATOM 2820 O SER A 359 -0.374 12.367 -8.244 1.00 97.96 O \\\\nATOM 2821 OG SER A 359 -2.534 10.252 -7.659 1.00 97.96 O \\\\nATOM 2822 N PRO A 360 -1.021 11.832 -10.342 1.00 97.02 N \\\\nATOM 2823 CA PRO A 360 -1.266 13.212 -10.746 1.00 97.02 C \\\\nATOM 2824 C PRO A 360 -2.301 13.928 -9.861 1.00 97.02 C \\\\nATOM 2825 CB PRO A 360 -1.701 13.112 -12.207 1.00 97.02 C \\\\nATOM 2826 O PRO A 360 -2.092 15.082 -9.499 1.00 97.02 O \\\\nATOM 2827 CG PRO A 360 -0.983 11.862 -12.707 1.00 97.02 C \\\\nATOM 2828 CD PRO A 360 -1.102 10.942 -11.498 1.00 97.02 C \\\\nATOM 2829 N ASN A 361 -3.351 13.228 -9.408 1.00 97.36 N \\\\nATOM 2830 CA ASN A 361 -4.341 13.769 -8.464 1.00 97.36 C \\\\nATOM 2831 C ASN A 361 -3.713 14.156 -7.117 1.00 97.36 C \\\\nATOM 2832 CB ASN A 361 -5.472 12.738 -8.310 1.00 97.36 C \\\\nATOM 2833 O ASN A 361 -3.924 15.261 -6.622 1.00 97.36 O \\\\nATOM 2834 CG ASN A 361 -6.573 13.205 -7.372 1.00 97.36 C \\\\nATOM 2835 ND2 ASN A 361 -7.574 13.894 -7.865 1.00 97.36 N \\\\nATOM 2836 OD1 ASN A 361 -6.548 12.926 -6.183 1.00 97.36 O \\\\nATOM 2837 N CYS A 362 -2.876 13.280 -6.556 1.00 96.14 N \\\\nATOM 2838 CA CYS A 362 -2.138 13.572 -5.328 1.00 96.14 C \\\\nATOM 2839 C CYS A 362 -1.158 14.740 -5.520 1.00 96.14 C \\\\nATOM 2840 CB CYS A 362 -1.401 12.295 -4.912 1.00 96.14 C \\\\nATOM 2841 O CYS A 362 -1.072 15.621 -4.668 1.00 96.14 O \\\\nATOM 2842 SG CYS A 362 -0.540 12.518 -3.334 1.00 96.14 S \\\\nATOM 2843 N ASN A 363 -0.430 14.758 -6.637 1.00 96.49 N \\\\nATOM 2844 CA ASN A 363 0.555 15.793 -6.934 1.00 96.49 C \\\\nATOM 2845 C ASN A 363 -0.107 17.169 -7.060 1.00 96.49 C \\\\nATOM 2846 CB ASN A 363 1.332 15.387 -8.199 1.00 96.49 C \\\\nATOM 2847 O ASN A 363 0.365 18.123 -6.448 1.00 96.49 O \\\\nATOM 2848 CG ASN A 363 2.246 14.195 -7.964 1.00 96.49 C \\\\nATOM 2849 ND2 ASN A 363 2.709 13.537 -8.998 1.00 96.49 N \\\\nATOM 2850 OD1 ASN A 363 2.590 13.845 -6.847 1.00 96.49 O \\\\nATOM 2851 N GLN A 364 -1.248 17.251 -7.749 1.00 95.57 N \\\\nATOM 2852 CA GLN A 364 -2.022 18.483 -7.863 1.00 95.57 C \\\\nATOM 2853 C GLN A 364 -2.529 18.980 -6.503 1.00 95.57 C \\\\nATOM 2854 CB GLN A 364 -3.164 18.253 -8.857 1.00 95.57 C \\\\nATOM 2855 O GLN A 364 -2.400 20.168 -6.215 1.00 95.57 O \\\\nATOM 2856 CG GLN A 364 -3.989 19.528 -9.096 1.00 95.57 C \\\\nATOM 2857 CD GLN A 364 -4.957 19.385 -10.265 1.00 95.57 C \\\\nATOM 2858 NE2 GLN A 364 -5.916 20.272 -10.402 1.00 95.57 N \\\\nATOM 2859 OE1 GLN A 364 -4.870 18.483 -11.078 1.00 95.57 O \\\\nATOM 2860 N ARG A 365 -3.030 18.089 -5.632 1.00 95.41 N \\\\nATOM 2861 CA ARG A 365 -3.483 18.449 -4.273 1.00 95.41 C \\\\nATOM 2862 C ARG A 365 -2.396 19.155 -3.458 1.00 95.41 C \\\\nATOM 2863 CB ARG A 365 -3.955 17.182 -3.540 1.00 95.41 C \\\\nATOM 2864 O ARG A 365 -2.692 20.091 -2.721 1.00 95.41 O \\\\nATOM 2865 CG ARG A 365 -4.554 17.483 -2.151 1.00 95.41 C \\\\nATOM 2866 CD ARG A 365 -4.732 16.213 -1.315 1.00 95.41 C \\\\nATOM 2867 NE ARG A 365 -5.657 15.286 -1.972 1.00 95.41 N \\\\nATOM 2868 NH1 ARG A 365 -4.525 13.324 -1.744 1.00 95.41 N \\\\nATOM 2869 NH2 ARG A 365 -6.301 13.471 -3.120 1.00 95.41 N \\\\nATOM 2870 CZ ARG A 365 -5.495 14.021 -2.269 1.00 95.41 C \\\\nATOM 2871 N TYR A 366 -1.151 18.699 -3.571 1.00 94.64 N \\\\nATOM 2872 CA TYR A 366 -0.016 19.262 -2.833 1.00 94.64 C \\\\nATOM 2873 C TYR A 366 0.746 20.354 -3.601 1.00 94.64 C \\\\nATOM 2874 CB TYR A 366 0.897 18.124 -2.357 1.00 94.64 C \\\\nATOM 2875 O TYR A 366 1.752 20.850 -3.098 1.00 94.64 O \\\\nATOM 2876 CG TYR A 366 0.253 17.198 -1.339 1.00 94.64 C \\\\nATOM 2877 CD1 TYR A 366 -0.097 17.689 -0.066 1.00 94.64 C \\\\nATOM 2878 CD2 TYR A 366 0.010 15.849 -1.656 1.00 94.64 C \\\\nATOM 2879 CE1 TYR A 366 -0.699 16.839 0.883 1.00 94.64 C \\\\nATOM 2880 CE2 TYR A 366 -0.598 14.996 -0.716 1.00 94.64 C \\\\nATOM 2881 OH TYR A 366 -1.546 14.667 1.459 1.00 94.64 O \\\\nATOM 2882 CZ TYR A 366 -0.953 15.490 0.554 1.00 94.64 C \\\\nATOM 2883 N GLY A 367 0.293 20.740 -4.800 1.00 95.30 N \\\\nATOM 2884 CA GLY A 367 0.976 21.736 -5.634 1.00 95.30 C \\\\nATOM 2885 C GLY A 367 2.334 21.268 -6.168 1.00 95.30 C \\\\nATOM 2886 O GLY A 367 3.211 22.085 -6.441 1.00 95.30 O \\\\nATOM 2887 N TRP A 368 2.542 19.957 -6.288 1.00 95.17 N \\\\nATOM 2888 CA TRP A 368 3.743 19.377 -6.881 1.00 95.17 C \\\\nATOM 2889 C TRP A 368 3.590 19.216 -8.391 1.00 95.17 C \\\\nATOM 2890 CB TRP A 368 4.063 18.034 -6.218 1.00 95.17 C \\\\nATOM 2891 O TRP A 368 2.484 19.074 -8.910 1.00 95.17 O \\\\nATOM 2892 CG TRP A 368 4.353 18.072 -4.751 1.00 95.17 C \\\\nATOM 2893 CD1 TRP A 368 4.860 19.125 -4.069 1.00 95.17 C \\\\nATOM 2894 CD2 TRP A 368 4.110 17.033 -3.755 1.00 95.17 C \\\\nATOM 2895 CE2 TRP A 368 4.511 17.533 -2.480 1.00 95.17 C \\\\nATOM 2896 CE3 TRP A 368 3.550 15.737 -3.790 1.00 95.17 C \\\\nATOM 2897 NE1 TRP A 368 4.962 18.809 -2.732 1.00 95.17 N \\\\nATOM 2898 CH2 TRP A 368 3.799 15.509 -1.367 1.00 95.17 C \\\\nATOM 2899 CZ2 TRP A 368 4.378 16.786 -1.301 1.00 95.17 C \\\\nATOM 2900 CZ3 TRP A 368 3.374 14.997 -2.605 1.00 95.17 C \\\\nATOM 2901 N HIS A 369 4.722 19.151 -9.096 1.00 95.30 N \\\\nATOM 2902 CA HIS A 369 4.724 18.820 -10.518 1.00 95.30 C \\\\nATOM 2903 C HIS A 369 3.951 17.502 -10.767 1.00 95.30 C \\\\nATOM 2904 CB HIS A 369 6.175 18.730 -11.012 1.00 95.30 C \\\\nATOM 2905 O HIS A 369 4.157 16.543 -10.016 1.00 95.30 O \\\\nATOM 2906 CG HIS A 369 6.259 18.606 -12.508 1.00 95.30 C \\\\nATOM 2907 CD2 HIS A 369 6.255 19.634 -13.411 1.00 95.30 C \\\\nATOM 2908 ND1 HIS A 369 6.303 17.435 -13.227 1.00 95.30 N \\\\nATOM 2909 CE1 HIS A 369 6.308 17.747 -14.536 1.00 95.30 C \\\\nATOM 2910 NE2 HIS A 369 6.277 19.073 -14.687 1.00 95.30 N \\\\nATOM 2911 N PRO A 370 3.101 17.384 -11.811 1.00 93.40 N \\\\nATOM 2912 CA PRO A 370 2.279 16.186 -12.047 1.00 93.40 C \\\\nATOM 2913 C PRO A 370 3.077 14.876 -12.133 1.00 93.40 C \\\\nATOM 2914 CB PRO A 370 1.543 16.461 -13.362 1.00 93.40 C \\\\nATOM 2915 O PRO A 370 2.563 13.802 -11.826 1.00 93.40 O \\\\nATOM 2916 CG PRO A 370 1.414 17.981 -13.379 1.00 93.40 C \\\\nATOM 2917 CD PRO A 370 2.718 18.445 -12.736 1.00 93.40 C \\\\nATOM 2918 N ALA A 371 4.357 14.974 -12.496 1.00 94.38 N \\\\nATOM 2919 CA ALA A 371 5.297 13.861 -12.604 1.00 94.38 C \\\\nATOM 2920 C ALA A 371 5.973 13.426 -11.297 1.00 94.38 C \\\\nATOM 2921 CB ALA A 371 6.387 14.274 -13.578 1.00 94.38 C \\\\nATOM 2922 O ALA A 371 6.759 12.473 -11.329 1.00 94.38 O \\\\nATOM 2923 N THR A 372 5.744 14.139 -10.194 1.00 95.75 N \\\\nATOM 2924 CA THR A 372 6.399 13.888 -8.909 1.00 95.75 C \\\\nATOM 2925 C THR A 372 6.146 12.462 -8.433 1.00 95.75 C \\\\nATOM 2926 CB THR A 372 5.952 14.920 -7.865 1.00 95.75 C \\\\nATOM 2927 O THR A 372 5.046 11.922 -8.567 1.00 95.75 O \\\\nATOM 2928 CG2 THR A 372 6.466 14.662 -6.449 1.00 95.75 C \\\\nATOM 2929 OG1 THR A 372 6.486 16.161 -8.254 1.00 95.75 O \\\\nATOM 2930 N VAL A 373 7.196 11.851 -7.883 1.00 97.76 N \\\\nATOM 2931 CA VAL A 373 7.174 10.489 -7.352 1.00 97.76 C \\\\nATOM 2932 C VAL A 373 7.317 10.554 -5.835 1.00 97.76 C \\\\nATOM 2933 CB VAL A 373 8.270 9.626 -7.999 1.00 97.76 C \\\\nATOM 2934 O VAL A 373 8.382 10.863 -5.303 1.00 97.76 O \\\\nATOM 2935 CG1 VAL A 373 8.211 8.193 -7.461 1.00 97.76 C \\\\nATOM 2936 CG2 VAL A 373 8.108 9.574 -9.523 1.00 97.76 C \\\\nATOM 2937 N CYS A 374 6.238 10.243 -5.128 1.00 96.60 N \\\\nATOM 2938 CA CYS A 374 6.176 10.254 -3.674 1.00 96.60 C \\\\nATOM 2939 C CYS A 374 6.661 8.916 -3.110 1.00 96.60 C \\\\nATOM 2940 CB CYS A 374 4.736 10.540 -3.234 1.00 96.60 C \\\\nATOM 2941 O CYS A 374 6.140 7.856 -3.455 1.00 96.60 O \\\\nATOM 2942 SG CYS A 374 4.133 12.066 -4.000 1.00 96.60 S \\\\nATOM 2943 N LYS A 375 7.632 8.944 -2.196 1.00 97.82 N \\\\nATOM 2944 CA LYS A 375 8.061 7.751 -1.455 1.00 97.82 C \\\\nATOM 2945 C LYS A 375 7.115 7.495 -0.279 1.00 97.82 C \\\\nATOM 2946 CB LYS A 375 9.514 7.947 -1.006 1.00 97.82 C \\\\nATOM 2947 O LYS A 375 6.924 8.382 0.546 1.00 97.82 O \\\\nATOM 2948 CG LYS A 375 10.077 6.726 -0.267 1.00 97.82 C \\\\nATOM 2949 CD LYS A 375 11.522 7.007 0.156 1.00 97.82 C \\\\nATOM 2950 CE LYS A 375 12.114 5.801 0.888 1.00 97.82 C \\\\nATOM 2951 NZ LYS A 375 13.500 6.086 1.337 1.00 97.82 N \\\\nATOM 2952 N ILE A 376 6.602 6.272 -0.154 1.00 97.37 N \\\\nATOM 2953 CA ILE A 376 5.853 5.795 1.017 1.00 97.37 C \\\\nATOM 2954 C ILE A 376 6.740 4.781 1.759 1.00 97.37 C \\\\nATOM 2955 CB ILE A 376 4.485 5.196 0.624 1.00 97.37 C \\\\nATOM 2956 O ILE A 376 6.971 3.680 1.248 1.00 97.37 O \\\\nATOM 2957 CG1 ILE A 376 3.673 6.151 -0.281 1.00 97.37 C \\\\nATOM 2958 CG2 ILE A 376 3.690 4.828 1.893 1.00 97.37 C \\\\nATOM 2959 CD1 ILE A 376 2.346 5.562 -0.771 1.00 97.37 C \\\\nATOM 2960 N PRO A 377 7.299 5.143 2.929 1.00 97.58 N \\\\nATOM 2961 CA PRO A 377 8.103 4.230 3.740 1.00 97.58 C \\\\nATOM 2962 C PRO A 377 7.293 3.046 4.303 1.00 97.58 C \\\\nATOM 2963 CB PRO A 377 8.691 5.083 4.871 1.00 97.58 C \\\\nATOM 2964 O PRO A 377 6.067 3.136 4.395 1.00 97.58 O \\\\nATOM 2965 CG PRO A 377 8.623 6.511 4.334 1.00 97.58 C \\\\nATOM 2966 CD PRO A 377 7.356 6.487 3.489 1.00 97.58 C \\\\nATOM 2967 N PRO A 378 7.964 1.961 4.737 1.00 97.58 N \\\\nATOM 2968 CA PRO A 378 7.325 0.838 5.428 1.00 97.58 C \\\\nATOM 2969 C PRO A 378 6.428 1.283 6.590 1.00 97.58 C \\\\nATOM 2970 CB PRO A 378 8.480 -0.034 5.930 1.00 97.58 C \\\\nATOM 2971 O PRO A 378 6.843 2.075 7.434 1.00 97.58 O \\\\nATOM 2972 CG PRO A 378 9.568 0.224 4.894 1.00 97.58 C \\\\nATOM 2973 CD PRO A 378 9.391 1.707 4.591 1.00 97.58 C \\\\nATOM 2974 N GLY A 379 5.193 0.777 6.633 1.00 92.70 N \\\\nATOM 2975 CA GLY A 379 4.200 1.105 7.662 1.00 92.70 C \\\\nATOM 2976 C GLY A 379 3.500 2.459 7.491 1.00 92.70 C \\\\nATOM 2977 O GLY A 379 2.587 2.768 8.258 1.00 92.70 O \\\\nATOM 2978 N CYS A 380 3.885 3.268 6.500 1.00 95.04 N \\\\nATOM 2979 CA CYS A 380 3.205 4.520 6.177 1.00 95.04 C \\\\nATOM 2980 C CYS A 380 2.071 4.305 5.165 1.00 95.04 C \\\\nATOM 2981 CB CYS A 380 4.220 5.558 5.676 1.00 95.04 C \\\\nATOM 2982 O CYS A 380 2.049 3.328 4.415 1.00 95.04 O \\\\nATOM 2983 SG CYS A 380 5.459 5.922 6.954 1.00 95.04 S \\\\nATOM 2984 N ASN A 381 1.143 5.261 5.116 1.00 94.89 N \\\\nATOM 2985 CA ASN A 381 0.094 5.328 4.105 1.00 94.89 C \\\\nATOM 2986 C ASN A 381 0.009 6.730 3.486 1.00 94.89 C \\\\nATOM 2987 CB ASN A 381 -1.248 4.848 4.687 1.00 94.89 C \\\\nATOM 2988 O ASN A 381 0.466 7.703 4.085 1.00 94.89 O \\\\nATOM 2989 CG ASN A 381 -1.764 5.753 5.791 1.00 94.89 C \\\\nATOM 2990 ND2 ASN A 381 -1.454 5.453 7.031 1.00 94.89 N \\\\nATOM 2991 OD1 ASN A 381 -2.427 6.748 5.560 1.00 94.89 O \\\\nATOM 2992 N LEU A 382 -0.562 6.818 2.286 1.00 94.95 N \\\\nATOM 2993 CA LEU A 382 -0.778 8.062 1.549 1.00 94.95 C \\\\nATOM 2994 C LEU A 382 -2.145 8.028 0.863 1.00 94.95 C \\\\nATOM 2995 CB LEU A 382 0.357 8.226 0.521 1.00 94.95 C \\\\nATOM 2996 O LEU A 382 -2.516 7.012 0.275 1.00 94.95 O \\\\nATOM 2997 CG LEU A 382 0.314 9.514 -0.324 1.00 94.95 C \\\\nATOM 2998 CD1 LEU A 382 0.495 10.768 0.533 1.00 94.95 C \\\\nATOM 2999 CD2 LEU A 382 1.430 9.477 -1.368 1.00 94.95 C \\\\nATOM 3000 N LYS A 383 -2.872 9.150 0.889 1.00 96.88 N \\\\nATOM 3001 CA LYS A 383 -4.083 9.348 0.081 1.00 96.88 C \\\\nATOM 3002 C LYS A 383 -3.681 9.634 -1.363 1.00 96.88 C \\\\nATOM 3003 CB LYS A 383 -4.923 10.485 0.675 1.00 96.88 C \\\\nATOM 3004 O LYS A 383 -3.294 10.754 -1.690 1.00 96.88 O \\\\nATOM 3005 CG LYS A 383 -6.269 10.625 -0.058 1.00 96.88 C \\\\nATOM 3006 CD LYS A 383 -7.087 11.818 0.451 1.00 96.88 C \\\\nATOM 3007 CE LYS A 383 -7.420 11.669 1.938 1.00 96.88 C \\\\nATOM 3008 NZ LYS A 383 -8.317 12.746 2.405 1.00 96.88 N \\\\nATOM 3009 N ILE A 384 -3.771 8.626 -2.220 1.00 97.74 N \\\\nATOM 3010 CA ILE A 384 -3.300 8.703 -3.605 1.00 97.74 C \\\\nATOM 3011 C ILE A 384 -4.361 9.256 -4.559 1.00 97.74 C \\\\nATOM 3012 CB ILE A 384 -2.738 7.347 -4.082 1.00 97.74 C \\\\nATOM 3013 O ILE A 384 -3.991 9.710 -5.633 1.00 97.74 O \\\\nATOM 3014 CG1 ILE A 384 -3.828 6.254 -4.146 1.00 97.74 C \\\\nATOM 3015 CG2 ILE A 384 -1.557 6.924 -3.190 1.00 97.74 C \\\\nATOM 3016 CD1 ILE A 384 -3.349 4.937 -4.762 1.00 97.74 C \\\\nATOM 3017 N PHE A 385 -5.646 9.255 -4.196 1.00 97.98 N \\\\nATOM 3018 CA PHE A 385 -6.714 9.810 -5.034 1.00 97.98 C \\\\nATOM 3019 C PHE A 385 -7.903 10.309 -4.205 1.00 97.98 C \\\\nATOM 3020 CB PHE A 385 -7.190 8.749 -6.032 1.00 97.98 C \\\\nATOM 3021 O PHE A 385 -8.200 9.731 -3.159 1.00 97.98 O \\\\nATOM 3022 CG PHE A 385 -7.952 9.324 -7.205 1.00 97.98 C \\\\nATOM 3023 CD1 PHE A 385 -9.359 9.385 -7.181 1.00 97.98 C \\\\nATOM 3024 CD2 PHE A 385 -7.253 9.791 -8.333 1.00 97.98 C \\\\nATOM 3025 CE1 PHE A 385 -10.052 9.907 -8.285 1.00 97.98 C \\\\nATOM 3026 CE2 PHE A 385 -7.959 10.308 -9.432 1.00 97.98 C \\\\nATOM 3027 CZ PHE A 385 -9.358 10.352 -9.416 1.00 97.98 C \\\\nATOM 3028 N ASN A 386 -8.595 11.344 -4.681 1.00 95.89 N \\\\nATOM 3029 CA ASN A 386 -9.868 11.815 -4.134 1.00 95.89 C \\\\nATOM 3030 C ASN A 386 -10.840 12.167 -5.281 1.00 95.89 C \\\\nATOM 3031 CB ASN A 386 -9.582 12.993 -3.183 1.00 95.89 C \\\\nATOM 3032 O ASN A 386 -10.531 12.988 -6.148 1.00 95.89 O \\\\nATOM 3033 CG ASN A 386 -10.836 13.650 -2.638 1.00 95.89 C \\\\nATOM 3034 ND2 ASN A 386 -11.081 13.677 -1.353 1.00 95.89 N \\\\nATOM 3035 OD1 ASN A 386 -11.657 14.142 -3.385 1.00 95.89 O \\\\nATOM 3036 N ASN A 387 -12.028 11.554 -5.262 1.00 94.32 N \\\\nATOM 3037 CA ASN A 387 -13.050 11.721 -6.296 1.00 94.32 C \\\\nATOM 3038 C ASN A 387 -13.654 13.130 -6.338 1.00 94.32 C \\\\nATOM 3039 CB ASN A 387 -14.183 10.698 -6.083 1.00 94.32 C \\\\nATOM 3040 O ASN A 387 -14.024 13.580 -7.415 1.00 94.32 O \\\\nATOM 3041 CG ASN A 387 -13.870 9.277 -6.515 1.00 94.32 C \\\\nATOM 3042 ND2 ASN A 387 -14.802 8.374 -6.338 1.00 94.32 N \\\\nATOM 3043 OD1 ASN A 387 -12.814 8.959 -7.028 1.00 94.32 O \\\\nATOM 3044 N GLN A 388 -13.768 13.834 -5.209 1.00 93.82 N \\\\nATOM 3045 CA GLN A 388 -14.294 15.206 -5.180 1.00 93.82 C \\\\nATOM 3046 C GLN A 388 -13.327 16.188 -5.848 1.00 93.82 C \\\\nATOM 3047 CB GLN A 388 -14.558 15.666 -3.740 1.00 93.82 C \\\\nATOM 3048 O GLN A 388 -13.753 17.058 -6.602 1.00 93.82 O \\\\nATOM 3049 CG GLN A 388 -15.637 14.855 -3.015 1.00 93.82 C \\\\nATOM 3050 CD GLN A 388 -15.860 15.367 -1.596 1.00 93.82 C \\\\nATOM 3051 NE2 GLN A 388 -17.079 15.365 -1.111 1.00 93.82 N \\\\nATOM 3052 OE1 GLN A 388 -14.960 15.786 -0.891 1.00 93.82 O \\\\nATOM 3053 N GLU A 389 -12.024 16.024 -5.615 1.00 94.83 N \\\\nATOM 3054 CA GLU A 389 -10.987 16.821 -6.276 1.00 94.83 C \\\\nATOM 3055 C GLU A 389 -10.980 16.567 -7.786 1.00 94.83 C \\\\nATOM 3056 CB GLU A 389 -9.615 16.480 -5.684 1.00 94.83 C \\\\nATOM 3057 O GLU A 389 -10.916 17.509 -8.573 1.00 94.83 O \\\\nATOM 3058 CG GLU A 389 -9.465 16.962 -4.234 1.00 94.83 C \\\\nATOM 3059 CD GLU A 389 -8.200 16.419 -3.565 1.00 94.83 C \\\\nATOM 3060 OE1 GLU A 389 -8.029 16.604 -2.342 1.00 94.83 O \\\\nATOM 3061 OE2 GLU A 389 -7.391 15.714 -4.210 1.00 94.83 O \\\\nATOM 3062 N PHE A 390 -11.113 15.301 -8.197 1.00 96.24 N \\\\nATOM 3063 CA PHE A 390 -11.250 14.953 -9.609 1.00 96.24 C \\\\nATOM 3064 C PHE A 390 -12.540 15.514 -10.225 1.00 96.24 C \\\\nATOM 3065 CB PHE A 390 -11.166 13.434 -9.773 1.00 96.24 C \\\\nATOM 3066 O PHE A 390 -12.490 16.068 -11.317 1.00 96.24 O \\\\nATOM 3067 CG PHE A 390 -11.298 12.992 -11.217 1.00 96.24 C \\\\nATOM 3068 CD1 PHE A 390 -12.518 12.467 -11.688 1.00 96.24 C \\\\nATOM 3069 CD2 PHE A 390 -10.216 13.152 -12.103 1.00 96.24 C \\\\nATOM 3070 CE1 PHE A 390 -12.650 12.096 -13.038 1.00 96.24 C \\\\nATOM 3071 CE2 PHE A 390 -10.352 12.779 -13.452 1.00 96.24 C \\\\nATOM 3072 CZ PHE A 390 -11.566 12.248 -13.917 1.00 96.24 C \\\\nATOM 3073 N ALA A 391 -13.674 15.437 -9.519 1.00 94.09 N \\\\nATOM 3074 CA ALA A 391 -14.953 15.999 -9.956 1.00 94.09 C \\\\nATOM 3075 C ALA A 391 -14.858 17.504 -10.230 1.00 94.09 C \\\\nATOM 3076 CB ALA A 391 -15.999 15.773 -8.856 1.00 94.09 C \\\\nATOM 3077 O ALA A 391 -15.314 17.984 -11.267 1.00 94.09 O \\\\nATOM 3078 N ALA A 392 -14.256 18.246 -9.295 1.00 94.21 N \\\\nATOM 3079 CA ALA A 392 -14.075 19.686 -9.418 1.00 94.21 C \\\\nATOM 3080 C ALA A 392 -13.184 20.033 -10.617 1.00 94.21 C \\\\nATOM 3081 CB ALA A 392 -13.490 20.214 -8.103 1.00 94.21 C \\\\nATOM 3082 O ALA A 392 -13.516 20.936 -11.383 1.00 94.21 O \\\\nATOM 3083 N LEU A 393 -12.094 19.286 -10.811 1.00 94.52 N \\\\nATOM 3084 CA LEU A 393 -11.209 19.462 -11.958 1.00 94.52 C \\\\nATOM 3085 C LEU A 393 -11.916 19.143 -13.280 1.00 94.52 C \\\\nATOM 3086 CB LEU A 393 -9.968 18.587 -11.751 1.00 94.52 C \\\\nATOM 3087 O LEU A 393 -11.835 19.930 -14.214 1.00 94.52 O \\\\nATOM 3088 CG LEU A 393 -8.927 18.738 -12.870 1.00 94.52 C \\\\nATOM 3089 CD1 LEU A 393 -8.401 20.170 -12.984 1.00 94.52 C \\\\nATOM 3090 CD2 LEU A 393 -7.771 17.797 -12.558 1.00 94.52 C \\\\nATOM 3091 N LEU A 394 -12.662 18.038 -13.344 1.00 94.94 N \\\\nATOM 3092 CA LEU A 394 -13.439 17.651 -14.520 1.00 94.94 C \\\\nATOM 3093 C LEU A 394 -14.450 18.735 -14.906 1.00 94.94 C \\\\nATOM 3094 CB LEU A 394 -14.099 16.288 -14.237 1.00 94.94 C \\\\nATOM 3095 O LEU A 394 -14.493 19.146 -16.063 1.00 94.94 O \\\\nATOM 3096 CG LEU A 394 -14.979 15.742 -15.376 1.00 94.94 C \\\\nATOM 3097 CD1 LEU A 394 -14.211 15.600 -16.687 1.00 94.94 C \\\\nATOM 3098 CD2 LEU A 394 -15.510 14.362 -14.978 1.00 94.94 C \\\\nATOM 3099 N ALA A 395 -15.207 19.256 -13.937 1.00 93.07 N \\\\nATOM 3100 CA ALA A 395 -16.156 20.342 -14.169 1.00 93.07 C \\\\nATOM 3101 C ALA A 395 -15.480 21.632 -14.670 1.00 93.07 C \\\\nATOM 3102 CB ALA A 395 -16.929 20.587 -12.868 1.00 93.07 C \\\\nATOM 3103 O ALA A 395 -16.045 22.343 -15.498 1.00 93.07 O \\\\nATOM 3104 N GLN A 396 -14.266 21.935 -14.201 1.00 93.21 N \\\\nATOM 3105 CA GLN A 396 -13.488 23.081 -14.681 1.00 93.21 C \\\\nATOM 3106 C GLN A 396 -12.965 22.861 -16.107 1.00 93.21 C \\\\nATOM 3107 CB GLN A 396 -12.330 23.364 -13.715 1.00 93.21 C \\\\nATOM 3108 O GLN A 396 -13.097 23.755 -16.943 1.00 93.21 O \\\\nATOM 3109 CG GLN A 396 -12.817 23.965 -12.389 1.00 93.21 C \\\\nATOM 3110 CD GLN A 396 -11.714 24.049 -11.337 1.00 93.21 C \\\\nATOM 3111 NE2 GLN A 396 -12.058 24.325 -10.098 1.00 93.21 N \\\\nATOM 3112 OE1 GLN A 396 -10.531 23.896 -11.587 1.00 93.21 O \\\\nATOM 3113 N SER A 397 -12.420 21.677 -16.400 1.00 93.63 N \\\\nATOM 3114 CA SER A 397 -11.832 21.340 -17.702 1.00 93.63 C \\\\nATOM 3115 C SER A 397 -12.854 21.267 -18.834 1.00 93.63 C \\\\nATOM 3116 CB SER A 397 -11.082 20.010 -17.619 1.00 93.63 C \\\\nATOM 3117 O SER A 397 -12.492 21.547 -19.971 1.00 93.63 O \\\\nATOM 3118 OG SER A 397 -9.968 20.134 -16.755 1.00 93.63 O \\\\nATOM 3119 N VAL A 398 -14.131 20.978 -18.552 1.00 91.77 N \\\\nATOM 3120 CA VAL A 398 -15.205 21.048 -19.564 1.00 91.77 C \\\\nATOM 3121 C VAL A 398 -15.265 22.425 -20.234 1.00 91.77 C \\\\nATOM 3122 CB VAL A 398 -16.559 20.665 -18.938 1.00 91.77 C \\\\nATOM 3123 O VAL A 398 -15.428 22.509 -21.448 1.00 91.77 O \\\\nATOM 3124 CG1 VAL A 398 -17.769 21.034 -19.801 1.00 91.77 C \\\\nATOM 3125 CG2 VAL A 398 -16.616 19.149 -18.736 1.00 91.77 C \\\\nATOM 3126 N ASN A 399 -15.031 23.506 -19.484 1.00 88.71 N \\\\nATOM 3127 CA ASN A 399 -15.034 24.867 -20.034 1.00 88.71 C \\\\nATOM 3128 C ASN A 399 -13.769 25.208 -20.843 1.00 88.71 C \\\\nATOM 3129 CB ASN A 399 -15.237 25.870 -18.890 1.00 88.71 C \\\\nATOM 3130 O ASN A 399 -13.734 26.231 -21.518 1.00 88.71 O \\\\nATOM 3131 CG ASN A 399 -16.513 25.607 -18.116 1.00 88.71 C \\\\nATOM 3132 ND2 ASN A 399 -16.405 25.322 -16.841 1.00 88.71 N \\\\nATOM 3133 OD1 ASN A 399 -17.610 25.615 -18.643 1.00 88.71 O \\\\nATOM 3134 N GLN A 400 -12.726 24.377 -20.767 1.00 90.24 N \\\\nATOM 3135 CA GLN A 400 -11.464 24.554 -21.497 1.00 90.24 C \\\\nATOM 3136 C GLN A 400 -11.454 23.802 -22.840 1.00 90.24 C \\\\nATOM 3137 CB GLN A 400 -10.297 24.102 -20.607 1.00 90.24 C \\\\nATOM 3138 O GLN A 400 -10.539 23.982 -23.641 1.00 90.24 O \\\\nATOM 3139 CG GLN A 400 -10.160 24.910 -19.309 1.00 90.24 C \\\\nATOM 3140 CD GLN A 400 -9.090 24.349 -18.376 1.00 90.24 C \\\\nATOM 3141 NE2 GLN A 400 -8.996 24.853 -17.167 1.00 90.24 N \\\\nATOM 3142 OE1 GLN A 400 -8.341 23.435 -18.680 1.00 90.24 O \\\\nATOM 3143 N GLY A 401 -12.472 22.976 -23.102 1.00 89.27 N \\\\nATOM 3144 CA GLY A 401 -12.641 22.243 -24.353 1.00 89.27 C \\\\nATOM 3145 C GLY A 401 -12.207 20.776 -24.292 1.00 89.27 C \\\\nATOM 3146 O GLY A 401 -11.748 20.264 -23.271 1.00 89.27 O \\\\nATOM 3147 N PHE A 402 -12.382 20.086 -25.421 1.00 90.38 N \\\\nATOM 3148 CA PHE A 402 -12.212 18.635 -25.535 1.00 90.38 C \\\\nATOM 3149 C PHE A 402 -10.825 18.148 -25.092 1.00 90.38 C \\\\nATOM 3150 CB PHE A 402 -12.499 18.227 -26.989 1.00 90.38 C \\\\nATOM 3151 O PHE A 402 -10.730 17.192 -24.327 1.00 90.38 O \\\\nATOM 3152 CG PHE A 402 -12.438 16.732 -27.227 1.00 90.38 C \\\\nATOM 3153 CD1 PHE A 402 -11.204 16.100 -27.479 1.00 90.38 C \\\\nATOM 3154 CD2 PHE A 402 -13.615 15.964 -27.177 1.00 90.38 C \\\\nATOM 3155 CE1 PHE A 402 -11.148 14.707 -27.666 1.00 90.38 C \\\\nATOM 3156 CE2 PHE A 402 -13.560 14.573 -27.372 1.00 90.38 C \\\\nATOM 3157 CZ PHE A 402 -12.327 13.944 -27.616 1.00 90.38 C \\\\nATOM 3158 N GLU A 403 -9.752 18.816 -25.531 1.00 91.17 N \\\\nATOM 3159 CA GLU A 403 -8.376 18.393 -25.238 1.00 91.17 C \\\\nATOM 3160 C GLU A 403 -8.076 18.432 -23.734 1.00 91.17 C \\\\nATOM 3161 CB GLU A 403 -7.395 19.281 -26.026 1.00 91.17 C \\\\nATOM 3162 O GLU A 403 -7.521 17.483 -23.187 1.00 91.17 O \\\\nATOM 3163 CG GLU A 403 -5.925 18.840 -25.911 1.00 91.17 C \\\\nATOM 3164 CD GLU A 403 -5.677 17.399 -26.387 1.00 91.17 C \\\\nATOM 3165 OE1 GLU A 403 -4.748 16.760 -25.836 1.00 91.17 O \\\\nATOM 3166 OE2 GLU A 403 -6.428 16.933 -27.273 1.00 91.17 O \\\\nATOM 3167 N ALA A 404 -8.515 19.483 -23.035 1.00 92.62 N \\\\nATOM 3168 CA ALA A 404 -8.321 19.609 -21.593 1.00 92.62 C \\\\nATOM 3169 C ALA A 404 -9.007 18.472 -20.823 1.00 92.62 C \\\\nATOM 3170 CB ALA A 404 -8.858 20.971 -21.154 1.00 92.62 C \\\\nATOM 3171 O ALA A 404 -8.413 17.896 -19.912 1.00 92.62 O \\\\nATOM 3172 N VAL A 405 -10.231 18.107 -21.221 1.00 93.34 N \\\\nATOM 3173 CA VAL A 405 -10.944 16.953 -20.659 1.00 93.34 C \\\\nATOM 3174 C VAL A 405 -10.209 15.657 -21.007 1.00 93.34 C \\\\nATOM 3175 CB VAL A 405 -12.409 16.916 -21.137 1.00 93.34 C \\\\nATOM 3176 O VAL A 405 -9.949 14.849 -20.123 1.00 93.34 O \\\\nATOM 3177 CG1 VAL A 405 -13.168 15.723 -20.550 1.00 93.34 C \\\\nATOM 3178 CG2 VAL A 405 -13.171 18.174 -20.705 1.00 93.34 C \\\\nATOM 3179 N TYR A 406 -9.798 15.465 -22.260 1.00 92.37 N \\\\nATOM 3180 CA TYR A 406 -9.100 14.254 -22.696 1.00 92.37 C \\\\nATOM 3181 C TYR A 406 -7.802 14.006 -21.904 1.00 92.37 C \\\\nATOM 3182 CB TYR A 406 -8.839 14.353 -24.203 1.00 92.37 C \\\\nATOM 3183 O TYR A 406 -7.530 12.876 -21.483 1.00 92.37 O \\\\nATOM 3184 CG TYR A 406 -8.253 13.085 -24.782 1.00 92.37 C \\\\nATOM 3185 CD1 TYR A 406 -6.866 12.983 -24.999 1.00 92.37 C \\\\nATOM 3186 CD2 TYR A 406 -9.099 12.000 -25.083 1.00 92.37 C \\\\nATOM 3187 CE1 TYR A 406 -6.320 11.791 -25.513 1.00 92.37 C \\\\nATOM 3188 CE2 TYR A 406 -8.557 10.807 -25.597 1.00 92.37 C \\\\nATOM 3189 OH TYR A 406 -6.648 9.555 -26.324 1.00 92.37 O \\\\nATOM 3190 CZ TYR A 406 -7.168 10.702 -25.813 1.00 92.37 C \\\\nATOM 3191 N GLN A 407 -7.043 15.062 -21.594 1.00 92.56 N \\\\nATOM 3192 CA GLN A 407 -5.833 14.987 -20.766 1.00 92.56 C \\\\nATOM 3193 C GLN A 407 -6.097 14.491 -19.332 1.00 92.56 C \\\\nATOM 3194 CB GLN A 407 -5.140 16.361 -20.741 1.00 92.56 C \\\\nATOM 3195 O GLN A 407 -5.215 13.866 -18.729 1.00 92.56 O \\\\nATOM 3196 CG GLN A 407 -4.521 16.759 -22.093 1.00 92.56 C \\\\nATOM 3197 CD GLN A 407 -3.387 15.857 -22.554 1.00 92.56 C \\\\nATOM 3198 NE2 GLN A 407 -3.095 15.834 -23.833 1.00 92.56 N \\\\nATOM 3199 OE1 GLN A 407 -2.752 15.147 -21.784 1.00 92.56 O \\\\nATOM 3200 N LEU A 408 -7.314 14.661 -18.794 1.00 94.48 N \\\\nATOM 3201 CA LEU A 408 -7.694 14.129 -17.477 1.00 94.48 C \\\\nATOM 3202 C LEU A 408 -7.704 12.599 -17.416 1.00 94.48 C \\\\nATOM 3203 CB LEU A 408 -9.060 14.664 -17.020 1.00 94.48 C \\\\nATOM 3204 O LEU A 408 -7.690 12.040 -16.318 1.00 94.48 O \\\\nATOM 3205 CG LEU A 408 -9.156 16.186 -16.858 1.00 94.48 C \\\\nATOM 3206 CD1 LEU A 408 -10.550 16.528 -16.344 1.00 94.48 C \\\\nATOM 3207 CD2 LEU A 408 -8.130 16.720 -15.861 1.00 94.48 C \\\\nATOM 3208 N THR A 409 -7.622 11.906 -18.555 1.00 94.82 N \\\\nATOM 3209 CA THR A 409 -7.381 10.454 -18.586 1.00 94.82 C \\\\nATOM 3210 C THR A 409 -6.137 10.100 -17.766 1.00 94.82 C \\\\nATOM 3211 CB THR A 409 -7.208 9.953 -20.028 1.00 94.82 C \\\\nATOM 3212 O THR A 409 -6.144 9.133 -17.007 1.00 94.82 O \\\\nATOM 3213 CG2 THR A 409 -7.149 8.427 -20.100 1.00 94.82 C \\\\nATOM 3214 OG1 THR A 409 -8.301 10.347 -20.817 1.00 94.82 O \\\\nATOM 3215 N ARG A 410 -5.094 10.946 -17.816 1.00 93.13 N \\\\nATOM 3216 CA ARG A 410 -3.854 10.766 -17.042 1.00 93.13 C \\\\nATOM 3217 C ARG A 410 -4.078 10.857 -15.534 1.00 93.13 C \\\\nATOM 3218 CB ARG A 410 -2.806 11.807 -17.467 1.00 93.13 C \\\\nATOM 3219 O ARG A 410 -3.379 10.185 -14.784 1.00 93.13 O \\\\nATOM 3220 CG ARG A 410 -2.404 11.694 -18.945 1.00 93.13 C \\\\nATOM 3221 CD ARG A 410 -1.350 12.752 -19.299 1.00 93.13 C \\\\nATOM 3222 NE ARG A 410 -0.998 12.695 -20.728 1.00 93.13 N \\\\nATOM 3223 NH1 ARG A 410 0.238 14.644 -20.846 1.00 93.13 N \\\\nATOM 3224 NH2 ARG A 410 -0.291 13.571 -22.708 1.00 93.13 N \\\\nATOM 3225 CZ ARG A 410 -0.356 13.632 -21.409 1.00 93.13 C \\\\nATOM 3226 N MET A 411 -5.054 11.647 -15.081 1.00 94.91 N \\\\nATOM 3227 CA MET A 411 -5.395 11.753 -13.657 1.00 94.91 C \\\\nATOM 3228 C MET A 411 -5.948 10.439 -13.107 1.00 94.91 C \\\\nATOM 3229 CB MET A 411 -6.416 12.876 -13.415 1.00 94.91 C \\\\nATOM 3230 O MET A 411 -5.793 10.166 -11.920 1.00 94.91 O \\\\nATOM 3231 CG MET A 411 -5.905 14.262 -13.817 1.00 94.91 C \\\\nATOM 3232 SD MET A 411 -4.534 14.885 -12.816 1.00 94.91 S \\\\nATOM 3233 CE MET A 411 -5.412 15.315 -11.297 1.00 94.91 C \\\\nATOM 3234 N CYS A 412 -6.558 9.620 -13.965 1.00 96.87 N \\\\nATOM 3235 CA CYS A 412 -7.174 8.354 -13.588 1.00 96.87 C \\\\nATOM 3236 C CYS A 412 -6.182 7.176 -13.543 1.00 96.87 C \\\\nATOM 3237 CB CYS A 412 -8.323 8.061 -14.551 1.00 96.87 C \\\\nATOM 3238 O CYS A 412 -6.571 6.071 -13.153 1.00 96.87 O \\\\nATOM 3239 SG CYS A 412 -9.484 9.454 -14.693 1.00 96.87 S \\\\nATOM 3240 N THR A 413 -4.917 7.407 -13.918 1.00 97.46 N \\\\nATOM 3241 CA THR A 413 -3.845 6.408 -13.909 1.00 97.46 C \\\\nATOM 3242 C THR A 413 -2.819 6.731 -12.826 1.00 97.46 C \\\\nATOM 3243 CB THR A 413 -3.174 6.281 -15.284 1.00 97.46 C \\\\nATOM 3244 O THR A 413 -2.224 7.807 -12.805 1.00 97.46 O \\\\nATOM 3245 CG2 THR A 413 -2.057 5.237 -15.300 1.00 97.46 C \\\\nATOM 3246 OG1 THR A 413 -4.123 5.875 -16.241 1.00 97.46 O \\\\nATOM 3247 N ILE A 414 -2.566 5.773 -11.934 1.00 98.40 N \\\\nATOM 3248 CA ILE A 414 -1.571 5.888 -10.861 1.00 98.40 C \\\\nATOM 3249 C ILE A 414 -0.518 4.805 -11.048 1.00 98.40 C \\\\nATOM 3250 CB ILE A 414 -2.229 5.818 -9.466 1.00 98.40 C \\\\nATOM 3251 O ILE A 414 -0.847 3.631 -11.200 1.00 98.40 O \\\\nATOM 3252 CG1 ILE A 414 -3.288 6.932 -9.308 1.00 98.40 C \\\\nATOM 3253 CG2 ILE A 414 -1.145 5.904 -8.372 1.00 98.40 C \\\\nATOM 3254 CD1 ILE A 414 -4.102 6.848 -8.014 1.00 98.40 C \\\\nATOM 3255 N ARG A 415 0.762 5.174 -10.987 1.00 98.53 N \\\\nATOM 3256 CA ARG A 415 1.872 4.219 -11.121 1.00 98.53 C \\\\nATOM 3257 C ARG A 415 2.588 4.041 -9.800 1.00 98.53 C \\\\nATOM 3258 CB ARG A 415 2.820 4.644 -12.244 1.00 98.53 C \\\\nATOM 3259 O ARG A 415 2.842 5.023 -9.102 1.00 98.53 O \\\\nATOM 3260 CG ARG A 415 2.070 4.671 -13.580 1.00 98.53 C \\\\nATOM 3261 CD ARG A 415 3.027 4.946 -14.731 1.00 98.53 C \\\\nATOM 3262 NE ARG A 415 2.281 4.998 -15.992 1.00 98.53 N \\\\nATOM 3263 NH1 ARG A 415 2.570 7.221 -16.554 1.00 98.53 N \\\\nATOM 3264 NH2 ARG A 415 1.353 5.820 -17.837 1.00 98.53 N \\\\nATOM 3265 CZ ARG A 415 2.087 6.027 -16.786 1.00 98.53 C \\\\nATOM 3266 N MET A 416 2.925 2.800 -9.456 1.00 98.54 N \\\\nATOM 3267 CA MET A 416 3.635 2.491 -8.216 1.00 98.54 C \\\\nATOM 3268 C MET A 416 4.779 1.514 -8.450 1.00 98.54 C \\\\nATOM 3269 CB MET A 416 2.700 1.961 -7.119 1.00 98.54 C \\\\nATOM 3270 O MET A 416 4.558 0.423 -8.959 1.00 98.54 O \\\\nATOM 3271 CG MET A 416 1.465 2.837 -6.929 1.00 98.54 C \\\\nATOM 3272 SD MET A 416 0.417 2.357 -5.534 1.00 98.54 S \\\\nATOM 3273 CE MET A 416 -1.180 2.527 -6.374 1.00 98.54 C \\\\nATOM 3274 N SER A 417 5.989 1.874 -8.031 1.00 98.68 N \\\\nATOM 3275 CA SER A 417 7.156 0.987 -8.055 1.00 98.68 C \\\\nATOM 3276 C SER A 417 7.431 0.411 -6.673 1.00 98.68 C \\\\nATOM 3277 CB SER A 417 8.388 1.709 -8.591 1.00 98.68 C \\\\nATOM 3278 O SER A 417 7.337 1.110 -5.659 1.00 98.68 O \\\\nATOM 3279 OG SER A 417 9.519 0.869 -8.532 1.00 98.68 O \\\\nATOM 3280 N PHE A 418 7.828 -0.858 -6.638 1.00 98.70 N \\\\nATOM 3281 CA PHE A 418 8.259 -1.538 -5.425 1.00 98.70 C \\\\nATOM 3282 C PHE A 418 9.772 -1.417 -5.254 1.00 98.70 C \\\\nATOM 3283 CB PHE A 418 7.837 -3.009 -5.470 1.00 98.70 C \\\\nATOM 3284 O PHE A 418 10.532 -1.666 -6.191 1.00 98.70 O \\\\nATOM 3285 CG PHE A 418 6.342 -3.225 -5.552 1.00 98.70 C \\\\nATOM 3286 CD1 PHE A 418 5.569 -3.241 -4.376 1.00 98.70 C \\\\nATOM 3287 CD2 PHE A 418 5.721 -3.406 -6.801 1.00 98.70 C \\\\nATOM 3288 CE1 PHE A 418 4.181 -3.446 -4.448 1.00 98.70 C \\\\nATOM 3289 CE2 PHE A 418 4.333 -3.607 -6.870 1.00 98.70 C \\\\nATOM 3290 CZ PHE A 418 3.561 -3.627 -5.696 1.00 98.70 C \\\\nATOM 3291 N VAL A 419 10.227 -1.120 -4.030 1.00 98.25 N \\\\nATOM 3292 CA VAL A 419 11.637 -1.131 -3.584 1.00 98.25 C \\\\nATOM 3293 C VAL A 419 12.523 -0.048 -4.215 1.00 98.25 C \\\\nATOM 3294 CB VAL A 419 12.276 -2.522 -3.799 1.00 98.25 C \\\\nATOM 3295 O VAL A 419 13.370 0.525 -3.529 1.00 98.25 O \\\\nATOM 3296 CG1 VAL A 419 13.640 -2.667 -3.112 1.00 98.25 C \\\\nATOM 3297 CG2 VAL A 419 11.402 -3.700 -3.340 1.00 98.25 C \\\\nATOM 3298 N LYS A 420 12.376 0.248 -5.511 1.00 97.93 N \\\\nATOM 3299 CA LYS A 420 13.226 1.176 -6.269 1.00 97.93 C \\\\nATOM 3300 C LYS A 420 12.432 2.405 -6.714 1.00 97.93 C \\\\nATOM 3301 CB LYS A 420 13.845 0.453 -7.483 1.00 97.93 C \\\\nATOM 3302 O LYS A 420 11.447 2.270 -7.432 1.00 97.93 O \\\\nATOM 3303 CG LYS A 420 14.640 -0.827 -7.164 1.00 97.93 C \\\\nATOM 3304 CD LYS A 420 15.786 -0.620 -6.162 1.00 97.93 C \\\\nATOM 3305 CE LYS A 420 16.542 -1.940 -5.960 1.00 97.93 C \\\\nATOM 3306 NZ LYS A 420 17.556 -1.843 -4.877 1.00 97.93 N \\\\nATOM 3307 N GLY A 421 12.905 3.593 -6.345 1.00 96.38 N \\\\nATOM 3308 CA GLY A 421 12.352 4.863 -6.819 1.00 96.38 C \\\\nATOM 3309 C GLY A 421 12.787 5.220 -8.239 1.00 96.38 C \\\\nATOM 3310 O GLY A 421 13.769 4.675 -8.761 1.00 96.38 O \\\\nATOM 3311 N TRP A 422 12.042 6.146 -8.838 1.00 98.03 N \\\\nATOM 3312 CA TRP A 422 12.339 6.792 -10.116 1.00 98.03 C \\\\nATOM 3313 C TRP A 422 11.929 8.271 -10.069 1.00 98.03 C \\\\nATOM 3314 CB TRP A 422 11.632 6.065 -11.270 1.00 98.03 C \\\\nATOM 3315 O TRP A 422 11.267 8.695 -9.122 1.00 98.03 O \\\\nATOM 3316 CG TRP A 422 10.193 6.426 -11.478 1.00 98.03 C \\\\nATOM 3317 CD1 TRP A 422 9.735 7.303 -12.401 1.00 98.03 C \\\\nATOM 3318 CD2 TRP A 422 9.016 5.985 -10.737 1.00 98.03 C \\\\nATOM 3319 CE2 TRP A 422 7.867 6.612 -11.307 1.00 98.03 C \\\\nATOM 3320 CE3 TRP A 422 8.800 5.122 -9.642 1.00 98.03 C \\\\nATOM 3321 NE1 TRP A 422 8.363 7.409 -12.311 1.00 98.03 N \\\\nATOM 3322 CH2 TRP A 422 6.387 5.528 -9.740 1.00 98.03 C \\\\nATOM 3323 CZ2 TRP A 422 6.571 6.373 -10.842 1.00 98.03 C \\\\nATOM 3324 CZ3 TRP A 422 7.500 4.913 -9.146 1.00 98.03 C \\\\nATOM 3325 N GLY A 423 12.309 9.041 -11.083 1.00 94.75 N \\\\nATOM 3326 CA GLY A 423 12.044 10.475 -11.190 1.00 94.75 C \\\\nATOM 3327 C GLY A 423 13.250 11.323 -10.786 1.00 94.75 C \\\\nATOM 3328 O GLY A 423 14.344 10.795 -10.600 1.00 94.75 O \\\\nATOM 3329 N ALA A 424 13.032 12.634 -10.641 1.00 90.85 N \\\\nATOM 3330 CA ALA A 424 14.086 13.644 -10.487 1.00 90.85 C \\\\nATOM 3331 C ALA A 424 15.119 13.325 -9.386 1.00 90.85 C \\\\nATOM 3332 CB ALA A 424 13.394 14.987 -10.215 1.00 90.85 C \\\\nATOM 3333 O ALA A 424 16.310 13.545 -9.571 1.00 90.85 O \\\\nATOM 3334 N GLU A 425 14.673 12.721 -8.282 1.00 88.72 N \\\\nATOM 3335 CA GLU A 425 15.503 12.405 -7.109 1.00 88.72 C \\\\nATOM 3336 C GLU A 425 16.249 11.058 -7.203 1.00 88.72 C \\\\nATOM 3337 CB GLU A 425 14.613 12.434 -5.855 1.00 88.72 C \\\\nATOM 3338 O GLU A 425 16.893 10.619 -6.248 1.00 88.72 O \\\\nATOM 3339 CG GLU A 425 13.885 13.769 -5.639 1.00 88.72 C \\\\nATOM 3340 CD GLU A 425 14.850 14.961 -5.596 1.00 88.72 C \\\\nATOM 3341 OE1 GLU A 425 14.500 15.996 -6.201 1.00 88.72 O \\\\nATOM 3342 OE2 GLU A 425 15.920 14.809 -4.965 1.00 88.72 O \\\\nATOM 3343 N TYR A 426 16.141 10.341 -8.325 1.00 94.62 N \\\\nATOM 3344 CA TYR A 426 16.680 8.990 -8.470 1.00 94.62 C \\\\nATOM 3345 C TYR A 426 17.466 8.829 -9.770 1.00 94.62 C \\\\nATOM 3346 CB TYR A 426 15.548 7.953 -8.380 1.00 94.62 C \\\\nATOM 3347 O TYR A 426 17.192 9.450 -10.787 1.00 94.62 O \\\\nATOM 3348 CG TYR A 426 14.758 7.996 -7.084 1.00 94.62 C \\\\nATOM 3349 CD1 TYR A 426 15.210 7.314 -5.935 1.00 94.62 C \\\\nATOM 3350 CD2 TYR A 426 13.601 8.790 -7.013 1.00 94.62 C \\\\nATOM 3351 CE1 TYR A 426 14.518 7.457 -4.715 1.00 94.62 C \\\\nATOM 3352 CE2 TYR A 426 12.900 8.928 -5.804 1.00 94.62 C \\\\nATOM 3353 OH TYR A 426 12.775 8.538 -3.454 1.00 94.62 O \\\\nATOM 3354 CZ TYR A 426 13.380 8.292 -4.645 1.00 94.62 C \\\\nATOM 3355 N ARG A 427 18.413 7.880 -9.782 1.00 94.90 N \\\\nATOM 3356 CA ARG A 427 19.152 7.509 -11.005 1.00 94.90 C \\\\nATOM 3357 C ARG A 427 18.225 7.072 -12.151 1.00 94.90 C \\\\nATOM 3358 CB ARG A 427 20.176 6.414 -10.660 1.00 94.90 C \\\\nATOM 3359 O ARG A 427 18.559 7.251 -13.317 1.00 94.90 O \\\\nATOM 3360 CG ARG A 427 21.004 5.978 -11.879 1.00 94.90 C \\\\nATOM 3361 CD ARG A 427 22.040 4.915 -11.509 1.00 94.90 C \\\\nATOM 3362 NE ARG A 427 22.699 4.393 -12.720 1.00 94.90 N \\\\nATOM 3363 NH1 ARG A 427 23.904 2.705 -11.734 1.00 94.90 N \\\\nATOM 3364 NH2 ARG A 427 24.039 3.017 -13.941 1.00 94.90 N \\\\nATOM 3365 CZ ARG A 427 23.540 3.376 -12.793 1.00 94.90 C \\\\nATOM 3366 N ARG A 428 17.099 6.434 -11.823 1.00 96.14 N \\\\nATOM 3367 CA ARG A 428 16.100 5.985 -12.799 1.00 96.14 C \\\\nATOM 3368 C ARG A 428 15.198 7.158 -13.132 1.00 96.14 C \\\\nATOM 3369 CB ARG A 428 15.268 4.838 -12.216 1.00 96.14 C \\\\nATOM 3370 O ARG A 428 14.451 7.585 -12.263 1.00 96.14 O \\\\nATOM 3371 CG ARG A 428 16.093 3.561 -12.091 1.00 96.14 C \\\\nATOM 3372 CD ARG A 428 15.265 2.482 -11.392 1.00 96.14 C \\\\nATOM 3373 NE ARG A 428 16.005 1.210 -11.355 1.00 96.14 N \\\\nATOM 3374 NH1 ARG A 428 17.371 1.723 -9.587 1.00 96.14 N \\\\nATOM 3375 NH2 ARG A 428 17.678 -0.190 -10.713 1.00 96.14 N \\\\nATOM 3376 CZ ARG A 428 17.010 0.917 -10.552 1.00 96.14 C \\\\nATOM 3377 N GLN A 429 15.240 7.633 -14.370 1.00 95.89 N \\\\nATOM 3378 CA GLN A 429 14.371 8.733 -14.772 1.00 95.89 C \\\\nATOM 3379 C GLN A 429 12.954 8.245 -15.040 1.00 95.89 C \\\\nATOM 3380 CB GLN A 429 14.980 9.512 -15.947 1.00 95.89 C \\\\nATOM 3381 O GLN A 429 12.033 8.853 -14.522 1.00 95.89 O \\\\nATOM 3382 CG GLN A 429 16.301 10.202 -15.553 1.00 95.89 C \\\\nATOM 3383 CD GLN A 429 16.155 11.065 -14.298 1.00 95.89 C \\\\nATOM 3384 NE2 GLN A 429 17.031 10.926 -13.331 1.00 95.89 N \\\\nATOM 3385 OE1 GLN A 429 15.202 11.803 -14.129 1.00 95.89 O \\\\nATOM 3386 N THR A 430 12.769 7.111 -15.726 1.00 96.48 N \\\\nATOM 3387 CA THR A 430 11.447 6.572 -16.089 1.00 96.48 C \\\\nATOM 3388 C THR A 430 10.968 5.455 -15.162 1.00 96.48 C \\\\nATOM 3389 CB THR A 430 11.421 6.056 -17.537 1.00 96.48 C \\\\nATOM 3390 O THR A 430 11.773 4.695 -14.610 1.00 96.48 O \\\\nATOM 3391 CG2 THR A 430 11.843 7.080 -18.590 1.00 96.48 C \\\\nATOM 3392 OG1 THR A 430 12.267 4.932 -17.662 1.00 96.48 O \\\\nATOM 3393 N VAL A 431 9.646 5.283 -15.053 1.00 97.27 N \\\\nATOM 3394 CA VAL A 431 9.054 4.138 -14.332 1.00 97.27 C \\\\nATOM 3395 C VAL A 431 9.428 2.805 -14.989 1.00 97.27 C \\\\nATOM 3396 CB VAL A 431 7.529 4.293 -14.205 1.00 97.27 C \\\\nATOM 3397 O VAL A 431 9.712 1.830 -14.299 1.00 97.27 O \\\\nATOM 3398 CG1 VAL A 431 6.798 4.130 -15.543 1.00 97.27 C \\\\nATOM 3399 CG2 VAL A 431 6.972 3.310 -13.171 1.00 97.27 C \\\\nATOM 3400 N THR A 432 9.565 2.786 -16.317 1.00 97.83 N \\\\nATOM 3401 CA THR A 432 9.991 1.622 -17.112 1.00 97.83 C \\\\nATOM 3402 C THR A 432 11.432 1.181 -16.834 1.00 97.83 C \\\\nATOM 3403 CB THR A 432 9.828 1.917 -18.611 1.00 97.83 C \\\\nATOM 3404 O THR A 432 11.830 0.084 -17.210 1.00 97.83 O \\\\nATOM 3405 CG2 THR A 432 8.359 2.070 -19.004 1.00 97.83 C \\\\nATOM 3406 OG1 THR A 432 10.470 3.129 -18.958 1.00 97.83 O \\\\nATOM 3407 N SER A 433 12.220 1.998 -16.126 1.00 97.46 N \\\\nATOM 3408 CA SER A 433 13.549 1.621 -15.624 1.00 97.46 C \\\\nATOM 3409 C SER A 433 13.496 0.910 -14.263 1.00 97.46 C \\\\nATOM 3410 CB SER A 433 14.424 2.869 -15.505 1.00 97.46 C \\\\nATOM 3411 O SER A 433 14.527 0.454 -13.744 1.00 97.46 O \\\\nATOM 3412 OG SER A 433 14.595 3.524 -16.742 1.00 97.46 O \\\\nATOM 3413 N THR A 434 12.325 0.861 -13.621 1.00 98.11 N \\\\nATOM 3414 CA THR A 434 12.142 0.204 -12.325 1.00 98.11 C \\\\nATOM 3415 C THR A 434 11.928 -1.301 -12.509 1.00 98.11 C \\\\nATOM 3416 CB THR A 434 11.031 0.812 -11.463 1.00 98.11 C \\\\nATOM 3417 O THR A 434 11.259 -1.723 -13.452 1.00 98.11 O \\\\nATOM 3418 CG2 THR A 434 11.186 2.317 -11.262 1.00 98.11 C \\\\nATOM 3419 OG1 THR A 434 9.764 0.546 -11.980 1.00 98.11 O \\\\nATOM 3420 N PRO A 435 12.504 -2.154 -11.642 1.00 98.30 N \\\\nATOM 3421 CA PRO A 435 12.450 -3.596 -11.871 1.00 98.30 C \\\\nATOM 3422 C PRO A 435 11.050 -4.194 -11.694 1.00 98.30 C \\\\nATOM 3423 CB PRO A 435 13.442 -4.209 -10.878 1.00 98.30 C \\\\nATOM 3424 O PRO A 435 10.746 -5.203 -12.319 1.00 98.30 O \\\\nATOM 3425 CG PRO A 435 14.335 -3.047 -10.462 1.00 98.30 C \\\\nATOM 3426 CD PRO A 435 13.396 -1.854 -10.532 1.00 98.30 C \\\\nATOM 3427 N CYS A 436 10.221 -3.614 -10.823 1.00 98.65 N \\\\nATOM 3428 CA CYS A 436 8.884 -4.108 -10.502 1.00 98.65 C \\\\nATOM 3429 C CYS A 436 7.965 -2.926 -10.214 1.00 98.65 C \\\\nATOM 3430 CB CYS A 436 8.944 -5.000 -9.249 1.00 98.65 C \\\\nATOM 3431 O CYS A 436 8.176 -2.221 -9.224 1.00 98.65 O \\\\nATOM 3432 SG CYS A 436 10.042 -6.419 -9.493 1.00 98.65 S \\\\nATOM 3433 N TRP A 437 6.930 -2.745 -11.023 1.00 98.76 N \\\\nATOM 3434 CA TRP A 437 5.951 -1.685 -10.817 1.00 98.76 C \\\\nATOM 3435 C TRP A 437 4.570 -2.099 -11.314 1.00 98.76 C \\\\nATOM 3436 CB TRP A 437 6.443 -0.390 -11.475 1.00 98.76 C \\\\nATOM 3437 O TRP A 437 4.419 -3.065 -12.058 1.00 98.76 O \\\\nATOM 3438 CG TRP A 437 6.614 -0.447 -12.954 1.00 98.76 C \\\\nATOM 3439 CD1 TRP A 437 7.657 -1.001 -13.607 1.00 98.76 C \\\\nATOM 3440 CD2 TRP A 437 5.717 0.067 -13.983 1.00 98.76 C \\\\nATOM 3441 CE2 TRP A 437 6.302 -0.203 -15.253 1.00 98.76 C \\\\nATOM 3442 CE3 TRP A 437 4.477 0.739 -13.970 1.00 98.76 C \\\\nATOM 3443 NE1 TRP A 437 7.475 -0.852 -14.960 1.00 98.76 N \\\\nATOM 3444 CH2 TRP A 437 4.433 0.768 -16.408 1.00 98.76 C \\\\nATOM 3445 CZ2 TRP A 437 5.676 0.125 -16.457 1.00 98.76 C \\\\nATOM 3446 CZ3 TRP A 437 3.846 1.096 -15.175 1.00 98.76 C \\\\nATOM 3447 N ILE A 438 3.554 -1.388 -10.843 1.00 98.75 N \\\\nATOM 3448 CA ILE A 438 2.160 -1.576 -11.224 1.00 98.75 C \\\\nATOM 3449 C ILE A 438 1.571 -0.277 -11.759 1.00 98.75 C \\\\nATOM 3450 CB ILE A 438 1.303 -2.146 -10.072 1.00 98.75 C \\\\nATOM 3451 O ILE A 438 1.939 0.818 -11.324 1.00 98.75 O \\\\nATOM 3452 CG1 ILE A 438 1.413 -1.301 -8.783 1.00 98.75 C \\\\nATOM 3453 CG2 ILE A 438 1.664 -3.623 -9.848 1.00 98.75 C \\\\nATOM 3454 CD1 ILE A 438 0.412 -1.684 -7.687 1.00 98.75 C \\\\nATOM 3455 N GLU A 439 0.626 -0.425 -12.674 1.00 98.66 N \\\\nATOM 3456 CA GLU A 439 -0.226 0.638 -13.185 1.00 98.66 C \\\\nATOM 3457 C GLU A 439 -1.659 0.385 -12.722 1.00 98.66 C \\\\nATOM 3458 CB GLU A 439 -0.113 0.684 -14.711 1.00 98.66 C \\\\nATOM 3459 O GLU A 439 -2.210 -0.693 -12.943 1.00 98.66 O \\\\nATOM 3460 CG GLU A 439 -0.773 1.930 -15.307 1.00 98.66 C \\\\nATOM 3461 CD GLU A 439 -0.329 2.117 -16.764 1.00 98.66 C \\\\nATOM 3462 OE1 GLU A 439 -0.586 1.190 -17.567 1.00 98.66 O \\\\nATOM 3463 OE2 GLU A 439 0.372 3.136 -17.029 1.00 98.66 O \\\\nATOM 3464 N LEU A 440 -2.231 1.368 -12.034 1.00 98.22 N \\\\nATOM 3465 CA LEU A 440 -3.578 1.347 -11.491 1.00 98.22 C \\\\nATOM 3466 C LEU A 440 -4.466 2.258 -12.334 1.00 98.22 C \\\\nATOM 3467 CB LEU A 440 -3.521 1.826 -10.023 1.00 98.22 C \\\\nATOM 3468 O LEU A 440 -4.170 3.444 -12.452 1.00 98.22 O \\\\nATOM 3469 CG LEU A 440 -4.725 1.370 -9.189 1.00 98.22 C \\\\nATOM 3470 CD1 LEU A 440 -4.507 -0.084 -8.800 1.00 98.22 C \\\\nATOM 3471 CD2 LEU A 440 -4.859 2.179 -7.899 1.00 98.22 C \\\\nATOM 3472 N HIS A 441 -5.560 1.729 -12.870 1.00 98.13 N \\\\nATOM 3473 CA HIS A 441 -6.609 2.516 -13.522 1.00 98.13 C \\\\nATOM 3474 C HIS A 441 -7.832 2.593 -12.619 1.00 98.13 C \\\\nATOM 3475 CB HIS A 441 -6.971 1.905 -14.878 1.00 98.13 C \\\\nATOM 3476 O HIS A 441 -8.337 1.558 -12.183 1.00 98.13 O \\\\nATOM 3477 CG HIS A 441 -5.885 1.987 -15.917 1.00 98.13 C \\\\nATOM 3478 CD2 HIS A 441 -4.763 2.768 -15.870 1.00 98.13 C \\\\nATOM 3479 ND1 HIS A 441 -5.880 1.348 -17.135 1.00 98.13 N \\\\nATOM 3480 CE1 HIS A 441 -4.779 1.739 -17.802 1.00 98.13 C \\\\nATOM 3481 NE2 HIS A 441 -4.070 2.613 -17.069 1.00 98.13 N \\\\nATOM 3482 N LEU A 442 -8.298 3.808 -12.333 1.00 97.65 N \\\\nATOM 3483 CA LEU A 442 -9.493 4.052 -11.528 1.00 97.65 C \\\\nATOM 3484 C LEU A 442 -10.723 4.098 -12.435 1.00 97.65 C \\\\nATOM 3485 CB LEU A 442 -9.317 5.340 -10.712 1.00 97.65 C \\\\nATOM 3486 O LEU A 442 -10.966 5.081 -13.135 1.00 97.65 O \\\\nATOM 3487 CG LEU A 442 -8.113 5.327 -9.756 1.00 97.65 C \\\\nATOM 3488 CD1 LEU A 442 -8.076 6.651 -9.009 1.00 97.65 C \\\\nATOM 3489 CD2 LEU A 442 -8.185 4.200 -8.722 1.00 97.65 C \\\\nATOM 3490 N ASN A 443 -11.505 3.022 -12.414 1.00 96.77 N \\\\nATOM 3491 CA ASN A 443 -12.575 2.797 -13.384 1.00 96.77 C \\\\nATOM 3492 C ASN A 443 -13.730 3.790 -13.230 1.00 96.77 C \\\\nATOM 3493 CB ASN A 443 -13.079 1.359 -13.224 1.00 96.77 C \\\\nATOM 3494 O ASN A 443 -14.340 4.164 -14.223 1.00 96.77 O \\\\nATOM 3495 CG ASN A 443 -12.053 0.308 -13.601 1.00 96.77 C \\\\nATOM 3496 ND2 ASN A 443 -12.176 -0.876 -13.059 1.00 96.77 N \\\\nATOM 3497 OD1 ASN A 443 -11.132 0.524 -14.365 1.00 96.77 O \\\\nATOM 3498 N GLY A 444 -14.029 4.226 -12.003 1.00 94.54 N \\\\nATOM 3499 CA GLY A 444 -15.098 5.191 -11.745 1.00 94.54 C \\\\nATOM 3500 C GLY A 444 -14.801 6.553 -12.378 1.00 94.54 C \\\\nATOM 3501 O GLY A 444 -15.563 7.000 -13.235 1.00 94.54 O \\\\nATOM 3502 N PRO A 445 -13.667 7.192 -12.030 1.00 95.57 N \\\\nATOM 3503 CA PRO A 445 -13.183 8.395 -12.703 1.00 95.57 C \\\\nATOM 3504 C PRO A 445 -13.102 8.266 -14.232 1.00 95.57 C \\\\nATOM 3505 CB PRO A 445 -11.812 8.667 -12.076 1.00 95.57 C \\\\nATOM 3506 O PRO A 445 -13.582 9.157 -14.930 1.00 95.57 O \\\\nATOM 3507 CG PRO A 445 -11.990 8.153 -10.650 1.00 95.57 C \\\\nATOM 3508 CD PRO A 445 -12.852 6.911 -10.854 1.00 95.57 C \\\\nATOM 3509 N LEU A 446 -12.584 7.146 -14.758 1.00 96.12 N \\\\nATOM 3510 CA LEU A 446 -12.530 6.893 -16.207 1.00 96.12 C \\\\nATOM 3511 C LEU A 446 -13.920 6.832 -16.847 1.00 96.12 C \\\\nATOM 3512 CB LEU A 446 -11.786 5.576 -16.497 1.00 96.12 C \\\\nATOM 3513 O LEU A 446 -14.143 7.458 -17.876 1.00 96.12 O \\\\nATOM 3514 CG LEU A 446 -10.261 5.663 -16.366 1.00 96.12 C \\\\nATOM 3515 CD1 LEU A 446 -9.644 4.269 -16.456 1.00 96.12 C \\\\nATOM 3516 CD2 LEU A 446 -9.629 6.538 -17.453 1.00 96.12 C \\\\nATOM 3517 N GLN A 447 -14.867 6.114 -16.239 1.00 93.99 N \\\\nATOM 3518 CA GLN A 447 -16.236 6.022 -16.746 1.00 93.99 C \\\\nATOM 3519 C GLN A 447 -16.928 7.388 -16.734 1.00 93.99 C \\\\nATOM 3520 CB GLN A 447 -17.025 5.007 -15.900 1.00 93.99 C \\\\nATOM 3521 O GLN A 447 -17.694 7.710 -17.641 1.00 93.99 O \\\\nATOM 3522 CG GLN A 447 -18.453 4.827 -16.434 1.00 93.99 C \\\\nATOM 3523 CD GLN A 447 -19.274 3.840 -15.619 1.00 93.99 C \\\\nATOM 3524 NE2 GLN A 447 -19.847 2.835 -16.240 1.00 93.99 N \\\\nATOM 3525 OE1 GLN A 447 -19.488 3.984 -14.428 1.00 93.99 O \\\\nATOM 3526 N TRP A 448 -16.685 8.201 -15.705 1.00 93.61 N \\\\nATOM 3527 CA TRP A 448 -17.250 9.544 -15.649 1.00 93.61 C \\\\nATOM 3528 C TRP A 448 -16.668 10.445 -16.736 1.00 93.61 C \\\\nATOM 3529 CB TRP A 448 -17.020 10.139 -14.266 1.00 93.61 C \\\\nATOM 3530 O TRP A 448 -17.416 11.158 -17.403 1.00 93.61 O \\\\nATOM 3531 CG TRP A 448 -17.873 11.319 -13.917 1.00 93.61 C \\\\nATOM 3532 CD1 TRP A 448 -18.899 11.839 -14.637 1.00 93.61 C \\\\nATOM 3533 CD2 TRP A 448 -17.793 12.127 -12.714 1.00 93.61 C \\\\nATOM 3534 CE2 TRP A 448 -18.872 13.057 -12.721 1.00 93.61 C \\\\nATOM 3535 CE3 TRP A 448 -16.926 12.138 -11.604 1.00 93.61 C \\\\nATOM 3536 NE1 TRP A 448 -19.496 12.864 -13.931 1.00 93.61 N \\\\nATOM 3537 CH2 TRP A 448 -18.250 13.892 -10.548 1.00 93.61 C \\\\nATOM 3538 CZ2 TRP A 448 -19.116 13.916 -11.649 1.00 93.61 C \\\\nATOM 3539 CZ3 TRP A 448 -17.154 13.009 -10.530 1.00 93.61 C \\\\nATOM 3540 N LEU A 449 -15.354 10.358 -16.948 1.00 94.28 N \\\\nATOM 3541 CA LEU A 449 -14.655 11.076 -18.003 1.00 94.28 C \\\\nATOM 3542 C LEU A 449 -15.173 10.695 -19.397 1.00 94.28 C \\\\nATOM 3543 CB LEU A 449 -13.153 10.779 -17.862 1.00 94.28 C \\\\nATOM 3544 O LEU A 449 -15.466 11.579 -20.195 1.00 94.28 O \\\\nATOM 3545 CG LEU A 449 -12.289 11.610 -18.815 1.00 94.28 C \\\\nATOM 3546 CD1 LEU A 449 -12.347 13.079 -18.418 1.00 94.28 C \\\\nATOM 3547 CD2 LEU A 449 -10.841 11.143 -18.742 1.00 94.28 C \\\\nATOM 3548 N ASP A 450 -15.347 9.401 -19.664 1.00 92.60 N \\\\nATOM 3549 CA ASP A 450 -15.885 8.874 -20.924 1.00 92.60 C \\\\nATOM 3550 C ASP A 450 -17.291 9.424 -21.227 1.00 92.60 C \\\\nATOM 3551 CB ASP A 450 -15.886 7.343 -20.822 1.00 92.60 C \\\\nATOM 3552 O ASP A 450 -17.558 9.945 -22.313 1.00 92.60 O \\\\nATOM 3553 CG ASP A 450 -16.420 6.688 -22.093 1.00 92.60 C \\\\nATOM 3554 OD1 ASP A 450 -15.698 6.749 -23.110 1.00 92.60 O \\\\nATOM 3555 OD2 ASP A 450 -17.537 6.128 -22.015 1.00 92.60 O \\\\nATOM 3556 N LYS A 451 -18.181 9.440 -20.225 1.00 91.83 N \\\\nATOM 3557 CA LYS A 451 -19.519 10.041 -20.363 1.00 91.83 C \\\\nATOM 3558 C LYS A 451 -19.490 11.549 -20.640 1.00 91.83 C \\\\nATOM 3559 CB LYS A 451 -20.346 9.800 -19.104 1.00 91.83 C \\\\nATOM 3560 O LYS A 451 -20.411 12.062 -21.264 1.00 91.83 O \\\\nATOM 3561 CG LYS A 451 -20.774 8.346 -18.886 1.00 91.83 C \\\\nATOM 3562 CD LYS A 451 -21.546 8.299 -17.564 1.00 91.83 C \\\\nATOM 3563 CE LYS A 451 -21.927 6.876 -17.167 1.00 91.83 C \\\\nATOM 3564 NZ LYS A 451 -22.588 6.894 -15.839 1.00 91.83 N \\\\nATOM 3565 N VAL A 452 -18.482 12.272 -20.151 1.00 91.75 N \\\\nATOM 3566 CA VAL A 452 -18.313 13.704 -20.452 1.00 91.75 C \\\\nATOM 3567 C VAL A 452 -17.764 13.886 -21.868 1.00 91.75 C \\\\nATOM 3568 CB VAL A 452 -17.432 14.393 -19.392 1.00 91.75 C \\\\nATOM 3569 O VAL A 452 -18.312 14.673 -22.635 1.00 91.75 O \\\\nATOM 3570 CG1 VAL A 452 -17.045 15.822 -19.781 1.00 91.75 C \\\\nATOM 3571 CG2 VAL A 452 -18.180 14.477 -18.054 1.00 91.75 C \\\\nATOM 3572 N LEU A 453 -16.729 13.131 -22.246 1.00 91.05 N \\\\nATOM 3573 CA LEU A 453 -16.115 13.199 -23.577 1.00 91.05 C \\\\nATOM 3574 C LEU A 453 -17.106 12.863 -24.695 1.00 91.05 C \\\\nATOM 3575 CB LEU A 453 -14.907 12.248 -23.633 1.00 91.05 C \\\\nATOM 3576 O LEU A 453 -17.135 13.558 -25.707 1.00 91.05 O \\\\nATOM 3577 CG LEU A 453 -13.657 12.782 -22.915 1.00 91.05 C \\\\nATOM 3578 CD1 LEU A 453 -12.607 11.677 -22.819 1.00 91.05 C \\\\nATOM 3579 CD2 LEU A 453 -13.034 13.964 -23.666 1.00 91.05 C \\\\nATOM 3580 N THR A 454 -17.974 11.870 -24.489 1.00 88.74 N \\\\nATOM 3581 CA THR A 454 -19.038 11.510 -25.446 1.00 88.74 C \\\\nATOM 3582 C THR A 454 -20.045 12.639 -25.704 1.00 88.74 C \\\\nATOM 3583 CB THR A 454 -19.797 10.249 -25.000 1.00 88.74 C \\\\nATOM 3584 O THR A 454 -20.705 12.629 -26.739 1.00 88.74 O \\\\nATOM 3585 CG2 THR A 454 -18.964 8.980 -25.160 1.00 88.74 C \\\\nATOM 3586 OG1 THR A 454 -20.152 10.317 -23.644 1.00 88.74 O \\\\nATOM 3587 N GLN A 455 -20.145 13.631 -24.811 1.00 86.80 N \\\\nATOM 3588 CA GLN A 455 -21.014 14.806 -24.960 1.00 86.80 C \\\\nATOM 3589 C GLN A 455 -20.277 16.044 -25.514 1.00 86.80 C \\\\nATOM 3590 CB GLN A 455 -21.657 15.128 -23.598 1.00 86.80 C \\\\nATOM 3591 O GLN A 455 -20.926 16.977 -25.978 1.00 86.80 O \\\\nATOM 3592 CG GLN A 455 -22.542 14.008 -23.028 1.00 86.80 C \\\\nATOM 3593 CD GLN A 455 -23.867 13.803 -23.755 1.00 86.80 C \\\\nATOM 3594 NE2 GLN A 455 -24.498 12.666 -23.561 1.00 86.80 N \\\\nATOM 3595 OE1 GLN A 455 -24.396 14.643 -24.464 1.00 86.80 O \\\\nATOM 3596 N MET A 456 -18.937 16.067 -25.489 1.00 83.78 N \\\\nATOM 3597 CA MET A 456 -18.105 17.230 -25.855 1.00 83.78 C \\\\nATOM 3598 C MET A 456 -17.816 17.361 -27.364 1.00 83.78 C \\\\nATOM 3599 CB MET A 456 -16.786 17.177 -25.059 1.00 83.78 C \\\\nATOM 3600 O MET A 456 -17.165 18.316 -27.781 1.00 83.78 O \\\\nATOM 3601 CG MET A 456 -16.946 17.591 -23.591 1.00 83.78 C \\\\nATOM 3602 SD MET A 456 -17.155 19.371 -23.298 1.00 83.78 S \\\\nATOM 3603 CE MET A 456 -15.520 20.010 -23.739 1.00 83.78 C \\\\nATOM 3604 N GLY A 457 -18.270 16.423 -28.200 1.00 82.72 N \\\\nATOM 3605 CA GLY A 457 -17.965 16.416 -29.636 1.00 82.72 C \\\\nATOM 3606 C GLY A 457 -16.554 15.898 -29.944 1.00 82.72 C \\\\nATOM 3607 O GLY A 457 -16.102 14.932 -29.336 1.00 82.72 O \\\\nATOM 3608 N SER A 458 -15.869 16.502 -30.919 1.00 82.57 N \\\\nATOM 3609 CA SER A 458 -14.536 16.088 -31.390 1.00 82.57 C \\\\nATOM 3610 C SER A 458 -13.502 17.216 -31.256 1.00 82.57 C \\\\nATOM 3611 CB SER A 458 -14.626 15.612 -32.849 1.00 82.57 C \\\\nATOM 3612 O SER A 458 -13.892 18.384 -31.189 1.00 82.57 O \\\\nATOM 3613 OG SER A 458 -14.997 16.664 -33.725 1.00 82.57 O \\\\nATOM 3614 N PRO A 459 -12.187 16.917 -31.300 1.00 83.95 N \\\\nATOM 3615 CA PRO A 459 -11.150 17.944 -31.404 1.00 83.95 C \\\\nATOM 3616 C PRO A 459 -11.398 18.912 -32.571 1.00 83.95 C \\\\nATOM 3617 CB PRO A 459 -9.830 17.189 -31.592 1.00 83.95 C \\\\nATOM 3618 O PRO A 459 -11.916 18.519 -33.619 1.00 83.95 O \\\\nATOM 3619 CG PRO A 459 -10.104 15.818 -30.980 1.00 83.95 C \\\\nATOM 3620 CD PRO A 459 -11.586 15.591 -31.267 1.00 83.95 C \\\\nATOM 3621 N SER A 460 -10.991 20.174 -32.407 1.00 82.81 N \\\\nATOM 3622 CA SER A 460 -11.108 21.203 -33.452 1.00 82.81 C \\\\nATOM 3623 C SER A 460 -10.191 20.929 -34.648 1.00 82.81 C \\\\nATOM 3624 CB SER A 460 -10.787 22.579 -32.856 1.00 82.81 C \\\\nATOM 3625 O SER A 460 -10.555 21.194 -35.795 1.00 82.81 O \\\\nATOM 3626 OG SER A 460 -9.520 22.558 -32.219 1.00 82.81 O \\\\nATOM 3627 N VAL A 461 -9.008 20.365 -34.391 1.00 84.86 N \\\\nATOM 3628 CA VAL A 461 -8.042 19.977 -35.421 1.00 84.86 C \\\\nATOM 3629 C VAL A 461 -8.386 18.581 -35.931 1.00 84.86 C \\\\nATOM 3630 CB VAL A 461 -6.596 20.052 -34.897 1.00 84.86 C \\\\nATOM 3631 O VAL A 461 -8.351 17.603 -35.184 1.00 84.86 O \\\\nATOM 3632 CG1 VAL A 461 -5.591 19.735 -36.012 1.00 84.86 C \\\\nATOM 3633 CG2 VAL A 461 -6.274 21.456 -34.364 1.00 84.86 C \\\\nATOM 3634 N ARG A 462 -8.705 18.476 -37.224 1.00 86.91 N \\\\nATOM 3635 CA ARG A 462 -8.912 17.178 -37.878 1.00 86.91 C \\\\nATOM 3636 C ARG A 462 -7.580 16.446 -38.015 1.00 86.91 C \\\\nATOM 3637 CB ARG A 462 -9.587 17.337 -39.247 1.00 86.91 C \\\\nATOM 3638 O ARG A 462 -6.581 17.039 -38.412 1.00 86.91 O \\\\nATOM 3639 CG ARG A 462 -11.013 17.890 -39.126 1.00 86.91 C \\\\nATOM 3640 CD ARG A 462 -11.684 17.905 -40.502 1.00 86.91 C \\\\nATOM 3641 NE ARG A 462 -13.033 18.495 -40.434 1.00 86.91 N \\\\nATOM 3642 NH1 ARG A 462 -13.544 18.318 -42.665 1.00 86.91 N \\\\nATOM 3643 NH2 ARG A 462 -15.020 19.234 -41.262 1.00 86.91 N \\\\nATOM 3644 CZ ARG A 462 -13.857 18.679 -41.451 1.00 86.91 C \\\\nATOM 3645 N CYS A 463 -7.589 15.148 -37.736 1.00 86.96 N \\\\nATOM 3646 CA CYS A 463 -6.437 14.287 -37.969 1.00 86.96 C \\\\nATOM 3647 C CYS A 463 -6.320 13.944 -39.464 1.00 86.96 C \\\\nATOM 3648 CB CYS A 463 -6.570 13.047 -37.079 1.00 86.96 C \\\\nATOM 3649 O CYS A 463 -7.328 13.671 -40.121 1.00 86.96 O \\\\nATOM 3650 SG CYS A 463 -4.996 12.153 -37.080 1.00 86.96 S \\\\nATOM 3651 N SER A 464 -5.099 13.967 -40.000 1.00 88.07 N \\\\nATOM 3652 CA SER A 464 -4.820 13.510 -41.363 1.00 88.07 C \\\\nATOM 3653 C SER A 464 -4.835 11.983 -41.414 1.00 88.07 C \\\\nATOM 3654 CB SER A 464 -3.461 14.040 -41.824 1.00 88.07 C \\\\nATOM 3655 O SER A 464 -4.310 11.321 -40.526 1.00 88.07 O \\\\nATOM 3656 OG SER A 464 -3.099 13.502 -43.084 1.00 88.07 O \\\\nATOM 3657 N SER A 465 -5.379 11.407 -42.485 1.00 91.00 N \\\\nATOM 3658 CA SER A 465 -5.290 9.965 -42.748 1.00 91.00 C \\\\nATOM 3659 C SER A 465 -3.976 9.551 -43.433 1.00 91.00 C \\\\nATOM 3660 CB SER A 465 -6.508 9.521 -43.561 1.00 91.00 C \\\\nATOM 3661 O SER A 465 -3.864 8.409 -43.870 1.00 91.00 O \\\\nATOM 3662 OG SER A 465 -6.528 10.173 -44.818 1.00 91.00 O \\\\nATOM 3663 N MET A 466 -3.021 10.477 -43.604 1.00 85.74 N \\\\nATOM 3664 CA MET A 466 -1.770 10.264 -44.353 1.00 85.74 C \\\\nATOM 3665 C MET A 466 -0.494 10.702 -43.614 1.00 85.74 C \\\\nATOM 3666 CB MET A 466 -1.822 11.027 -45.692 1.00 85.74 C \\\\nATOM 3667 O MET A 466 0.590 10.472 -44.144 1.00 85.74 O \\\\nATOM 3668 CG MET A 466 -2.996 10.644 -46.597 1.00 85.74 C \\\\nATOM 3669 SD MET A 466 -2.952 11.423 -48.240 1.00 85.74 S \\\\nATOM 3670 CE MET A 466 -1.732 10.371 -49.073 1.00 85.74 C \\\\nATOM 3671 N SER A 467 -0.609 11.397 -42.475 1.00 72.38 N \\\\nATOM 3672 CA SER A 467 0.539 11.969 -41.746 1.00 72.38 C \\\\nATOM 3673 C SER A 467 1.298 10.949 -40.918 1.00 72.38 C \\\\nATOM 3674 CB SER A 467 0.108 13.100 -40.821 1.00 72.38 C \\\\nATOM 3675 O SER A 467 0.599 10.142 -40.264 1.00 72.38 O \\\\nATOM 3676 OG SER A 467 -0.858 12.568 -39.944 1.00 72.38 O \\\\nATOM 3677 OXT SER A 467 2.532 11.126 -40.865 1.00 72.38 O \\\\nTER 3678 SER A 467 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 9, 'score': 0}, {'residue_no': 10, 'score': 0}, {'residue_no': 11, 'score': 0}, {'residue_no': 12, 'score': 0}, {'residue_no': 13, 'score': 0}, {'residue_no': 14, 'score': 0}, {'residue_no': 15, 'score': 0}, {'residue_no': 16, 'score': 0}, {'residue_no': 17, 'score': 0}, {'residue_no': 18, 'score': 0}, {'residue_no': 19, 'score': 0}, {'residue_no': 20, 'score': 0}, {'residue_no': 21, 'score': 0}, {'residue_no': 22, 'score': 0}, {'residue_no': 23, 'score': 0}, {'residue_no': 24, 'score': 0}, {'residue_no': 25, 'score': 0}, {'residue_no': 26, 'score': 0}, {'residue_no': 27, 'score': 0}, {'residue_no': 28, 'score': 0}, {'residue_no': 29, 'score': 0}, {'residue_no': 30, 'score': 0}, {'residue_no': 31, 'score': 0}, {'residue_no': 32, 'score': 0}, {'residue_no': 33, 'score': 0}, {'residue_no': 34, 'score': 0}, {'residue_no': 35, 'score': 0}, {'residue_no': 36, 'score': 0}, {'residue_no': 37, 'score': 0}, {'residue_no': 38, 'score': 0}, {'residue_no': 39, 'score': 0}, {'residue_no': 40, 'score': 0}, {'residue_no': 41, 'score': 0}, {'residue_no': 42, 'score': 0}, {'residue_no': 43, 'score': 0}, {'residue_no': 44, 'score': 0}, {'residue_no': 45, 'score': 0}, {'residue_no': 46, 'score': 0}, {'residue_no': 47, 'score': 0}, {'residue_no': 48, 'score': 0}, {'residue_no': 49, 'score': 0}, {'residue_no': 50, 'score': 0}, {'residue_no': 51, 'score': 0}, {'residue_no': 52, 'score': 0}, {'residue_no': 53, 'score': 0}, {'residue_no': 54, 'score': 0}, {'residue_no': 55, 'score': 0}, {'residue_no': 56, 'score': 0}, {'residue_no': 57, 'score': 0}, {'residue_no': 58, 'score': 0}, {'residue_no': 59, 'score': 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{'residue_no': 419, 'score': 0.2302}, {'residue_no': 420, 'score': 0.2175}, {'residue_no': 421, 'score': 0.2119}, {'residue_no': 422, 'score': 0.2108}, {'residue_no': 423, 'score': 0.2133}, {'residue_no': 424, 'score': 0.2155}, {'residue_no': 425, 'score': 0.2078}], 'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 3 (P84022) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 425 UNP P84022 SMAD3_HUMAN 1 425 \\\\nSEQRES 1 A 425 MET SER SER ILE LEU PRO PHE THR PRO PRO ILE VAL LYS \\\\nSEQRES 2 A 425 ARG LEU LEU GLY TRP LYS LYS GLY GLU GLN ASN GLY GLN \\\\nSEQRES 3 A 425 GLU GLU LYS TRP CYS GLU LYS ALA VAL LYS SER LEU VAL \\\\nSEQRES 4 A 425 LYS LYS LEU LYS LYS THR GLY GLN LEU ASP GLU LEU GLU \\\\nSEQRES 5 A 425 LYS ALA ILE THR THR GLN ASN VAL ASN THR LYS CYS ILE \\\\nSEQRES 6 A 425 THR ILE PRO ARG SER LEU ASP GLY ARG LEU GLN VAL SER \\\\nSEQRES 7 A 425 HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG LEU \\\\nSEQRES 8 A 425 TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU ARG \\\\nSEQRES 9 A 425 ALA MET GLU LEU CYS GLU PHE ALA PHE ASN MET LYS LYS \\\\nSEQRES 10 A 425 ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG VAL \\\\nSEQRES 11 A 425 GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG HIS \\\\nSEQRES 12 A 425 THR GLU ILE PRO ALA GLU PHE PRO PRO LEU ASP ASP TYR \\\\nSEQRES 13 A 425 SER HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA GLY \\\\nSEQRES 14 A 425 ILE GLU PRO GLN SER ASN ILE PRO GLU THR PRO PRO PRO \\\\nSEQRES 15 A 425 GLY TYR LEU SER GLU ASP GLY GLU THR SER ASP HIS GLN \\\\nSEQRES 16 A 425 MET ASN HIS SER MET ASP ALA GLY SER PRO ASN LEU SER \\\\nSEQRES 17 A 425 PRO ASN PRO MET SER PRO ALA HIS ASN ASN LEU ASP LEU \\\\nSEQRES 18 A 425 GLN PRO VAL THR TYR CYS GLU PRO ALA PHE TRP CYS SER \\\\nSEQRES 19 A 425 ILE SER TYR TYR GLU LEU ASN GLN ARG VAL GLY GLU THR \\\\nSEQRES 20 A 425 PHE HIS ALA SER GLN PRO SER MET THR VAL ASP GLY PHE \\\\nSEQRES 21 A 425 THR ASP PRO SER ASN SER GLU ARG PHE CYS LEU GLY LEU \\\\nSEQRES 22 A 425 LEU SER ASN VAL ASN ARG ASN ALA ALA VAL GLU LEU THR \\\\nSEQRES 23 A 425 ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU TYR TYR ILE \\\\nSEQRES 24 A 425 GLY GLY GLU VAL PHE ALA GLU CYS LEU SER ASP SER ALA \\\\nSEQRES 25 A 425 ILE PHE VAL GLN SER PRO ASN CYS ASN GLN ARG TYR GLY \\\\nSEQRES 26 A 425 TRP HIS PRO ALA THR VAL CYS LYS ILE PRO PRO GLY CYS \\\\nSEQRES 27 A 425 ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE ALA ALA LEU \\\\nSEQRES 28 A 425 LEU ALA GLN SER VAL ASN GLN GLY PHE GLU ALA VAL TYR \\\\nSEQRES 29 A 425 GLN LEU THR ARG MET CYS THR ILE ARG MET SER PHE VAL \\\\nSEQRES 30 A 425 LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN THR VAL THR \\\\nSEQRES 31 A 425 SER THR PRO CYS TRP ILE GLU LEU HIS LEU ASN GLY PRO \\\\nSEQRES 32 A 425 LEU GLN TRP LEU ASP LYS VAL LEU THR GLN MET GLY SER \\\\nSEQRES 33 A 425 PRO SER ILE ARG CYS SER SER VAL SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 4.273 0.848 52.113 1.00 39.24 N \\\\nATOM 2 CA MET A 1 3.232 1.902 52.065 1.00 39.24 C \\\\nATOM 3 C MET A 1 2.383 1.673 50.826 1.00 39.24 C \\\\nATOM 4 CB MET A 1 3.847 3.308 52.057 1.00 39.24 C \\\\nATOM 5 O MET A 1 2.942 1.318 49.796 1.00 39.24 O \\\\nATOM 6 CG MET A 1 4.474 3.642 53.416 1.00 39.24 C \\\\nATOM 7 SD MET A 1 5.360 5.216 53.426 1.00 39.24 S \\\\nATOM 8 CE MET A 1 5.935 5.252 55.146 1.00 39.24 C \\\\nATOM 9 N SER A 2 1.062 1.771 50.948 1.00 36.12 N \\\\nATOM 10 CA SER A 2 0.109 1.246 49.960 1.00 36.12 C \\\\nATOM 11 C SER A 2 0.079 2.048 48.655 1.00 36.12 C \\\\nATOM 12 CB SER A 2 -1.295 1.213 50.580 1.00 36.12 C \\\\nATOM 13 O SER A 2 -0.137 3.258 48.672 1.00 36.12 O \\\\nATOM 14 OG SER A 2 -1.227 0.650 51.880 1.00 36.12 O \\\\nATOM 15 N SER A 3 0.231 1.370 47.514 1.00 38.89 N \\\\nATOM 16 CA SER A 3 0.023 1.960 46.189 1.00 38.89 C \\\\nATOM 17 C SER A 3 -1.462 2.235 45.957 1.00 38.89 C \\\\nATOM 18 CB SER A 3 0.557 1.029 45.093 1.00 38.89 C \\\\nATOM 19 O SER A 3 -2.252 1.303 45.792 1.00 38.89 O \\\\nATOM 20 OG SER A 3 -0.053 -0.245 45.163 1.00 38.89 O \\\\nATOM 21 N ILE A 4 -1.855 3.506 45.916 1.00 47.07 N \\\\nATOM 22 CA ILE A 4 -3.232 3.888 45.596 1.00 47.07 C \\\\nATOM 23 C ILE A 4 -3.496 3.548 44.123 1.00 47.07 C \\\\nATOM 24 CB ILE A 4 -3.468 5.379 45.927 1.00 47.07 C \\\\nATOM 25 O ILE A 4 -2.938 4.179 43.224 1.00 47.07 O \\\\nATOM 26 CG1 ILE A 4 -3.261 5.625 47.443 1.00 47.07 C \\\\nATOM 27 CG2 ILE A 4 -4.879 5.821 45.493 1.00 47.07 C \\\\nATOM 28 CD1 ILE A 4 -3.274 7.105 47.845 1.00 47.07 C \\\\nATOM 29 N LEU A 5 -4.344 2.546 43.868 1.00 53.20 N \\\\nATOM 30 CA LEU A 5 -4.810 2.232 42.516 1.00 53.20 C \\\\nATOM 31 C LEU A 5 -5.549 3.457 41.941 1.00 53.20 C \\\\nATOM 32 CB LEU A 5 -5.721 0.989 42.534 1.00 53.20 C \\\\nATOM 33 O LEU A 5 -6.408 4.021 42.625 1.00 53.20 O \\\\nATOM 34 CG LEU A 5 -4.992 -0.340 42.812 1.00 53.20 C \\\\nATOM 35 CD1 LEU A 5 -6.017 -1.450 43.037 1.00 53.20 C \\\\nATOM 36 CD2 LEU A 5 -4.094 -0.756 41.643 1.00 53.20 C \\\\nATOM 37 N PRO A 6 -5.246 3.897 40.705 1.00 60.37 N \\\\nATOM 38 CA PRO A 6 -5.812 5.125 40.159 1.00 60.37 C \\\\nATOM 39 C PRO A 6 -7.330 4.999 39.986 1.00 60.37 C \\\\nATOM 40 CB PRO A 6 -5.074 5.367 38.837 1.00 60.37 C \\\\nATOM 41 O PRO A 6 -7.816 4.186 39.200 1.00 60.37 O \\\\nATOM 42 CG PRO A 6 -4.604 3.971 38.422 1.00 60.37 C \\\\nATOM 43 CD PRO A 6 -4.319 3.294 39.760 1.00 60.37 C \\\\nATOM 44 N PHE A 7 -8.088 5.832 40.702 1.00 70.62 N \\\\nATOM 45 CA PHE A 7 -9.549 5.804 40.675 1.00 70.62 C \\\\nATOM 46 C PHE A 7 -10.094 6.178 39.288 1.00 70.62 C \\\\nATOM 47 CB PHE A 7 -10.103 6.723 41.773 1.00 70.62 C \\\\nATOM 48 O PHE A 7 -10.023 7.331 38.853 1.00 70.62 O \\\\nATOM 49 CG PHE A 7 -11.618 6.706 41.884 1.00 70.62 C \\\\nATOM 50 CD1 PHE A 7 -12.391 7.683 41.227 1.00 70.62 C \\\\nATOM 51 CD2 PHE A 7 -12.256 5.721 42.662 1.00 70.62 C \\\\nATOM 52 CE1 PHE A 7 -13.792 7.682 41.356 1.00 70.62 C \\\\nATOM 53 CE2 PHE A 7 -13.657 5.718 42.788 1.00 70.62 C \\\\nATOM 54 CZ PHE A 7 -14.425 6.699 42.137 1.00 70.62 C \\\\nATOM 55 N THR A 8 -10.670 5.201 38.590 1.00 75.98 N \\\\nATOM 56 CA THR A 8 -11.340 5.419 37.302 1.00 75.98 C \\\\nATOM 57 C THR A 8 -12.798 5.827 37.530 1.00 75.98 C \\\\nATOM 58 CB THR A 8 -11.204 4.193 36.395 1.00 75.98 C \\\\nATOM 59 O THR A 8 -13.551 5.029 38.095 1.00 75.98 O \\\\nATOM 60 CG2 THR A 8 -11.939 4.349 35.065 1.00 75.98 C \\\\nATOM 61 OG1 THR A 8 -9.832 4.107 36.111 1.00 75.98 O \\\\nATOM 62 N PRO A 9 -13.225 7.032 37.086 1.00 83.88 N \\\\nATOM 63 CA PRO A 9 -14.572 7.540 37.343 1.00 83.88 C \\\\nATOM 64 C PRO A 9 -15.673 6.578 36.863 1.00 83.88 C \\\\nATOM 65 CB PRO A 9 -14.661 8.884 36.610 1.00 83.88 C \\\\nATOM 66 O PRO A 9 -15.524 6.006 35.780 1.00 83.88 O \\\\nATOM 67 CG PRO A 9 -13.212 9.362 36.576 1.00 83.88 C \\\\nATOM 68 CD PRO A 9 -12.428 8.062 36.428 1.00 83.88 C \\\\nATOM 69 N PRO A 10 -16.809 6.445 37.578 1.00 90.89 N \\\\nATOM 70 CA PRO A 10 -17.865 5.488 37.225 1.00 90.89 C \\\\nATOM 71 C PRO A 10 -18.361 5.599 35.776 1.00 90.89 C \\\\nATOM 72 CB PRO A 10 -18.993 5.742 38.231 1.00 90.89 C \\\\nATOM 73 O PRO A 10 -18.535 4.588 35.102 1.00 90.89 O \\\\nATOM 74 CG PRO A 10 -18.247 6.237 39.468 1.00 90.89 C \\\\nATOM 75 CD PRO A 10 -17.097 7.049 38.875 1.00 90.89 C \\\\nATOM 76 N ILE A 11 -18.503 6.820 35.248 1.00 92.27 N \\\\nATOM 77 CA ILE A 11 -18.903 7.038 33.849 1.00 92.27 C \\\\nATOM 78 C ILE A 11 -17.867 6.545 32.827 1.00 92.27 C \\\\nATOM 79 CB ILE A 11 -19.300 8.510 33.624 1.00 92.27 C \\\\nATOM 80 O ILE A 11 -18.248 6.053 31.772 1.00 92.27 O \\\\nATOM 81 CG1 ILE A 11 -19.974 8.665 32.243 1.00 92.27 C \\\\nATOM 82 CG2 ILE A 11 -18.109 9.479 33.789 1.00 92.27 C \\\\nATOM 83 CD1 ILE A 11 -20.932 9.855 32.186 1.00 92.27 C \\\\nATOM 84 N VAL A 12 -16.570 6.592 33.149 1.00 93.66 N \\\\nATOM 85 CA VAL A 12 -15.523 6.020 32.287 1.00 93.66 C \\\\nATOM 86 C VAL A 12 -15.661 4.498 32.246 1.00 93.66 C \\\\nATOM 87 CB VAL A 12 -14.116 6.446 32.749 1.00 93.66 C \\\\nATOM 88 O VAL A 12 -15.583 3.927 31.165 1.00 93.66 O \\\\nATOM 89 CG1 VAL A 12 -12.997 5.748 31.970 1.00 93.66 C \\\\nATOM 90 CG2 VAL A 12 -13.919 7.961 32.599 1.00 93.66 C \\\\nATOM 91 N LYS A 13 -15.937 3.848 33.388 1.00 92.88 N \\\\nATOM 92 CA LYS A 13 -16.201 2.399 33.430 1.00 92.88 C \\\\nATOM 93 C LYS A 13 -17.434 2.024 32.600 1.00 92.88 C \\\\nATOM 94 CB LYS A 13 -16.346 1.887 34.873 1.00 92.88 C \\\\nATOM 95 O LYS A 13 -17.344 1.111 31.788 1.00 92.88 O \\\\nATOM 96 CG LYS A 13 -15.076 2.061 35.721 1.00 92.88 C \\\\nATOM 97 CD LYS A 13 -15.226 1.310 37.053 1.00 92.88 C \\\\nATOM 98 CE LYS A 13 -13.955 1.424 37.902 1.00 92.88 C \\\\nATOM 99 NZ LYS A 13 -14.041 0.572 39.118 1.00 92.88 N \\\\nATOM 100 N ARG A 14 -18.548 2.762 32.738 1.00 93.78 N \\\\nATOM 101 CA ARG A 14 -19.767 2.548 31.930 1.00 93.78 C \\\\nATOM 102 C ARG A 14 -19.486 2.672 30.430 1.00 93.78 C \\\\nATOM 103 CB ARG A 14 -20.903 3.501 32.350 1.00 93.78 C \\\\nATOM 104 O ARG A 14 -19.812 1.762 29.681 1.00 93.78 O \\\\nATOM 105 CG ARG A 14 -21.494 3.160 33.730 1.00 93.78 C \\\\nATOM 106 CD ARG A 14 -22.747 3.992 34.049 1.00 93.78 C \\\\nATOM 107 NE ARG A 14 -22.461 5.438 34.153 1.00 93.78 N \\\\nATOM 108 NH1 ARG A 14 -24.649 6.160 34.141 1.00 93.78 N \\\\nATOM 109 NH2 ARG A 14 -23.035 7.644 34.071 1.00 93.78 N \\\\nATOM 110 CZ ARG A 14 -23.376 6.396 34.150 1.00 93.78 C \\\\nATOM 111 N LEU A 15 -18.822 3.747 29.998 1.00 95.91 N \\\\nATOM 112 CA LEU A 15 -18.482 3.969 28.586 1.00 95.91 C \\\\nATOM 113 C LEU A 15 -17.500 2.923 28.024 1.00 95.91 C \\\\nATOM 114 CB LEU A 15 -17.910 5.388 28.430 1.00 95.91 C \\\\nATOM 115 O LEU A 15 -17.610 2.564 26.853 1.00 95.91 O \\\\nATOM 116 CG LEU A 15 -18.943 6.527 28.539 1.00 95.91 C \\\\nATOM 117 CD1 LEU A 15 -18.201 7.866 28.557 1.00 95.91 C \\\\nATOM 118 CD2 LEU A 15 -19.925 6.546 27.366 1.00 95.91 C \\\\nATOM 119 N LEU A 16 -16.567 2.412 28.835 1.00 94.13 N \\\\nATOM 120 CA LEU A 16 -15.676 1.311 28.444 1.00 94.13 C \\\\nATOM 121 C LEU A 16 -16.401 -0.038 28.358 1.00 94.13 C \\\\nATOM 122 CB LEU A 16 -14.492 1.222 29.420 1.00 94.13 C \\\\nATOM 123 O LEU A 16 -16.011 -0.863 27.540 1.00 94.13 O \\\\nATOM 124 CG LEU A 16 -13.472 2.357 29.249 1.00 94.13 C \\\\nATOM 125 CD1 LEU A 16 -12.531 2.383 30.449 1.00 94.13 C \\\\nATOM 126 CD2 LEU A 16 -12.618 2.203 27.986 1.00 94.13 C \\\\nATOM 127 N GLY A 17 -17.481 -0.245 29.117 1.00 93.26 N \\\\nATOM 128 CA GLY A 17 -18.336 -1.435 29.003 1.00 93.26 C \\\\nATOM 129 C GLY A 17 -19.018 -1.590 27.636 1.00 93.26 C \\\\nATOM 130 O GLY A 17 -19.403 -2.694 27.270 1.00 93.26 O \\\\nATOM 131 N TRP A 18 -19.112 -0.509 26.853 1.00 94.37 N \\\\nATOM 132 CA TRP A 18 -19.606 -0.526 25.470 1.00 94.37 C \\\\nATOM 133 C TRP A 18 -18.494 -0.673 24.414 1.00 94.37 C \\\\nATOM 134 CB TRP A 18 -20.455 0.728 25.232 1.00 94.37 C \\\\nATOM 135 O TRP A 18 -18.788 -0.656 23.216 1.00 94.37 O \\\\nATOM 136 CG TRP A 18 -21.736 0.776 26.007 1.00 94.37 C \\\\nATOM 137 CD1 TRP A 18 -21.931 1.414 27.182 1.00 94.37 C \\\\nATOM 138 CD2 TRP A 18 -23.021 0.170 25.667 1.00 94.37 C \\\\nATOM 139 CE2 TRP A 18 -23.955 0.477 26.701 1.00 94.37 C \\\\nATOM 140 CE3 TRP A 18 -23.489 -0.612 24.590 1.00 94.37 C \\\\nATOM 141 NE1 TRP A 18 -23.237 1.240 27.597 1.00 94.37 N \\\\nATOM 142 CH2 TRP A 18 -25.718 -0.746 25.586 1.00 94.37 C \\\\nATOM 143 CZ2 TRP A 18 -25.283 0.029 26.674 1.00 94.37 C \\\\nATOM 144 CZ3 TRP A 18 -24.821 -1.071 24.553 1.00 94.37 C \\\\nATOM 145 N LYS A 19 -17.220 -0.789 24.822 1.00 93.60 N \\\\nATOM 146 CA LYS A 19 -16.084 -0.967 23.904 1.00 93.60 C \\\\nATOM 147 C LYS A 19 -16.252 -2.261 23.100 1.00 93.60 C \\\\nATOM 148 CB LYS A 19 -14.760 -0.988 24.693 1.00 93.60 C \\\\nATOM 149 O LYS A 19 -16.579 -3.304 23.660 1.00 93.60 O \\\\nATOM 150 CG LYS A 19 -13.503 -0.930 23.802 1.00 93.60 C \\\\nATOM 151 CD LYS A 19 -12.226 -1.437 24.497 1.00 93.60 C \\\\nATOM 152 CE LYS A 19 -12.183 -2.968 24.676 1.00 93.60 C \\\\nATOM 153 NZ LYS A 19 -11.800 -3.697 23.436 1.00 93.60 N \\\\nATOM 154 N LYS A 20 -15.966 -2.216 21.800 1.00 91.32 N \\\\nATOM 155 CA LYS A 20 -15.914 -3.401 20.929 1.00 91.32 C \\\\nATOM 156 C LYS A 20 -14.490 -3.979 20.863 1.00 91.32 C \\\\nATOM 157 CB LYS A 20 -16.505 -3.040 19.552 1.00 91.32 C \\\\nATOM 158 O LYS A 20 -13.519 -3.312 21.226 1.00 91.32 O \\\\nATOM 159 CG LYS A 20 -17.955 -2.527 19.601 1.00 91.32 C \\\\nATOM 160 CD LYS A 20 -18.979 -3.550 20.111 1.00 91.32 C \\\\nATOM 161 CE LYS A 20 -20.374 -2.919 20.037 1.00 91.32 C \\\\nATOM 162 NZ LYS A 20 -21.437 -3.873 20.436 1.00 91.32 N \\\\nATOM 163 N GLY A 21 -14.358 -5.219 20.397 1.00 81.67 N \\\\nATOM 164 CA GLY A 21 -13.065 -5.891 20.200 1.00 81.67 C \\\\nATOM 165 C GLY A 21 -12.430 -6.446 21.479 1.00 81.67 C \\\\nATOM 166 O GLY A 21 -12.852 -6.136 22.595 1.00 81.67 O \\\\nATOM 167 N GLU A 22 -11.402 -7.268 21.296 1.00 73.16 N \\\\nATOM 168 CA GLU A 22 -10.807 -8.129 22.325 1.00 73.16 C \\\\nATOM 169 C GLU A 22 -10.076 -7.372 23.455 1.00 73.16 C \\\\nATOM 170 CB GLU A 22 -9.896 -9.162 21.638 1.00 73.16 C \\\\nATOM 171 O GLU A 22 -9.916 -6.143 23.435 1.00 73.16 O \\\\nATOM 172 CG GLU A 22 -10.687 -10.037 20.647 1.00 73.16 C \\\\nATOM 173 CD GLU A 22 -9.842 -11.154 20.025 1.00 73.16 C \\\\nATOM 174 OE1 GLU A 22 -10.462 -12.159 19.619 1.00 73.16 O \\\\nATOM 175 OE2 GLU A 22 -8.606 -10.975 19.959 1.00 73.16 O \\\\nATOM 176 N GLN A 23 -9.677 -8.115 24.493 1.00 63.69 N \\\\nATOM 177 CA GLN A 23 -9.051 -7.596 25.714 1.00 63.69 C \\\\nATOM 178 C GLN A 23 -7.518 -7.703 25.659 1.00 63.69 C \\\\nATOM 179 CB GLN A 23 -9.645 -8.273 26.962 1.00 63.69 C \\\\nATOM 180 O GLN A 23 -6.890 -8.444 26.413 1.00 63.69 O \\\\nATOM 181 CG GLN A 23 -11.129 -7.933 27.172 1.00 63.69 C \\\\nATOM 182 CD GLN A 23 -11.699 -8.529 28.459 1.00 63.69 C \\\\nATOM 183 NE2 GLN A 23 -13.005 -8.607 28.586 1.00 63.69 N \\\\nATOM 184 OE1 GLN A 23 -11.010 -8.940 29.374 1.00 63.69 O \\\\nATOM 185 N ASN A 24 -6.894 -6.916 24.782 1.00 71.71 N \\\\nATOM 186 CA ASN A 24 -5.439 -6.776 24.752 1.00 71.71 C \\\\nATOM 187 C ASN A 24 -4.978 -5.762 25.814 1.00 71.71 C \\\\nATOM 188 CB ASN A 24 -5.008 -6.406 23.321 1.00 71.71 C \\\\nATOM 189 O ASN A 24 -5.207 -4.560 25.680 1.00 71.71 O \\\\nATOM 190 CG ASN A 24 -5.145 -7.581 22.369 1.00 71.71 C \\\\nATOM 191 ND2 ASN A 24 -5.467 -7.332 21.123 1.00 71.71 N \\\\nATOM 192 OD1 ASN A 24 -4.943 -8.719 22.744 1.00 71.71 O \\\\nATOM 193 N GLY A 25 -4.286 -6.210 26.868 1.00 75.50 N \\\\nATOM 194 CA GLY A 25 -4.008 -5.386 28.061 1.00 75.50 C \\\\nATOM 195 C GLY A 25 -3.187 -4.097 27.844 1.00 75.50 C \\\\nATOM 196 O GLY A 25 -3.244 -3.176 28.665 1.00 75.50 O \\\\nATOM 197 N GLN A 26 -2.430 -3.977 26.746 1.00 77.51 N \\\\nATOM 198 CA GLN A 26 -1.778 -2.713 26.361 1.00 77.51 C \\\\nATOM 199 C GLN A 26 -2.749 -1.751 25.656 1.00 77.51 C \\\\nATOM 200 CB GLN A 26 -0.555 -3.004 25.477 1.00 77.51 C \\\\nATOM 201 O GLN A 26 -2.683 -0.536 25.861 1.00 77.51 O \\\\nATOM 202 CG GLN A 26 0.283 -1.736 25.216 1.00 77.51 C \\\\nATOM 203 CD GLN A 26 1.514 -1.993 24.352 1.00 77.51 C \\\\nATOM 204 NE2 GLN A 26 2.425 -1.051 24.240 1.00 77.51 N \\\\nATOM 205 OE1 GLN A 26 1.687 -3.027 23.745 1.00 77.51 O \\\\nATOM 206 N GLU A 27 -3.650 -2.291 24.839 1.00 83.83 N \\\\nATOM 207 CA GLU A 27 -4.675 -1.543 24.116 1.00 83.83 C \\\\nATOM 208 C GLU A 27 -5.765 -1.040 25.064 1.00 83.83 C \\\\nATOM 209 CB GLU A 27 -5.237 -2.448 23.019 1.00 83.83 C \\\\nATOM 210 O GLU A 27 -6.132 0.131 25.007 1.00 83.83 O \\\\nATOM 211 CG GLU A 27 -6.292 -1.739 22.170 1.00 83.83 C \\\\nATOM 212 CD GLU A 27 -6.606 -2.516 20.890 1.00 83.83 C \\\\nATOM 213 OE1 GLU A 27 -6.997 -1.820 19.927 1.00 83.83 O \\\\nATOM 214 OE2 GLU A 27 -6.412 -3.753 20.889 1.00 83.83 O \\\\nATOM 215 N GLU A 28 -6.189 -1.861 26.023 1.00 86.39 N \\\\nATOM 216 CA GLU A 28 -7.170 -1.496 27.046 1.00 86.39 C \\\\nATOM 217 C GLU A 28 -6.731 -0.262 27.858 1.00 86.39 C \\\\nATOM 218 CB GLU A 28 -7.381 -2.720 27.939 1.00 86.39 C \\\\nATOM 219 O GLU A 28 -7.491 0.700 28.008 1.00 86.39 O \\\\nATOM 220 CG GLU A 28 -8.544 -2.503 28.910 1.00 86.39 C \\\\nATOM 221 CD GLU A 28 -8.803 -3.737 29.776 1.00 86.39 C \\\\nATOM 222 OE1 GLU A 28 -9.988 -3.932 30.119 1.00 86.39 O \\\\nATOM 223 OE2 GLU A 28 -7.809 -4.416 30.120 1.00 86.39 O \\\\nATOM 224 N LYS A 29 -5.456 -0.210 28.275 1.00 89.47 N \\\\nATOM 225 CA LYS A 29 -4.847 0.972 28.919 1.00 89.47 C \\\\nATOM 226 C LYS A 29 -4.855 2.214 28.021 1.00 89.47 C \\\\nATOM 227 CB LYS A 29 -3.401 0.651 29.334 1.00 89.47 C \\\\nATOM 228 O LYS A 29 -4.849 3.338 28.529 1.00 89.47 O \\\\nATOM 229 CG LYS A 29 -3.332 -0.299 30.536 1.00 89.47 C \\\\nATOM 230 CD LYS A 29 -1.881 -0.697 30.847 1.00 89.47 C \\\\nATOM 231 CE LYS A 29 -1.878 -1.706 32.000 1.00 89.47 C \\\\nATOM 232 NZ LYS A 29 -0.524 -2.251 32.277 1.00 89.47 N \\\\nATOM 233 N TRP A 30 -4.836 2.050 26.699 1.00 92.08 N \\\\nATOM 234 CA TRP A 30 -4.953 3.163 25.757 1.00 92.08 C \\\\nATOM 235 C TRP A 30 -6.415 3.594 25.561 1.00 92.08 C \\\\nATOM 236 CB TRP A 30 -4.245 2.826 24.440 1.00 92.08 C \\\\nATOM 237 O TRP A 30 -6.694 4.792 25.632 1.00 92.08 O \\\\nATOM 238 CG TRP A 30 -4.246 3.969 23.477 1.00 92.08 C \\\\nATOM 239 CD1 TRP A 30 -3.329 4.961 23.418 1.00 92.08 C \\\\nATOM 240 CD2 TRP A 30 -5.266 4.301 22.489 1.00 92.08 C \\\\nATOM 241 CE2 TRP A 30 -4.898 5.529 21.862 1.00 92.08 C \\\\nATOM 242 CE3 TRP A 30 -6.468 3.691 22.071 1.00 92.08 C \\\\nATOM 243 NE1 TRP A 30 -3.720 5.898 22.481 1.00 92.08 N \\\\nATOM 244 CH2 TRP A 30 -6.859 5.472 20.450 1.00 92.08 C \\\\nATOM 245 CZ2 TRP A 30 -5.674 6.113 20.851 1.00 92.08 C \\\\nATOM 246 CZ3 TRP A 30 -7.259 4.273 21.064 1.00 92.08 C \\\\nATOM 247 N CYS A 31 -7.352 2.652 25.423 1.00 93.06 N \\\\nATOM 248 CA CYS A 31 -8.793 2.918 25.376 1.00 93.06 C \\\\nATOM 249 C CYS A 31 -9.267 3.664 26.631 1.00 93.06 C \\\\nATOM 250 CB CYS A 31 -9.547 1.589 25.225 1.00 93.06 C \\\\nATOM 251 O CYS A 31 -9.973 4.667 26.526 1.00 93.06 O \\\\nATOM 252 SG CYS A 31 -9.173 0.837 23.618 1.00 93.06 S \\\\nATOM 253 N GLU A 32 -8.811 3.253 27.818 1.00 93.85 N \\\\nATOM 254 CA GLU A 32 -9.129 3.942 29.068 1.00 93.85 C \\\\nATOM 255 C GLU A 32 -8.646 5.403 29.051 1.00 93.85 C \\\\nATOM 256 CB GLU A 32 -8.528 3.173 30.256 1.00 93.85 C \\\\nATOM 257 O GLU A 32 -9.396 6.315 29.410 1.00 93.85 O \\\\nATOM 258 CG GLU A 32 -9.135 3.703 31.560 1.00 93.85 C \\\\nATOM 259 CD GLU A 32 -8.376 3.311 32.819 1.00 93.85 C \\\\nATOM 260 OE1 GLU A 32 -9.063 3.201 33.856 1.00 93.85 O \\\\nATOM 261 OE2 GLU A 32 -7.156 3.567 32.892 1.00 93.85 O \\\\nATOM 262 N LYS A 33 -7.422 5.662 28.568 1.00 94.20 N \\\\nATOM 263 CA LYS A 33 -6.902 7.028 28.384 1.00 94.20 C \\\\nATOM 264 C LYS A 33 -7.714 7.822 27.350 1.00 94.20 C \\\\nATOM 265 CB LYS A 33 -5.416 6.983 27.997 1.00 94.20 C \\\\nATOM 266 O LYS A 33 -7.950 9.012 27.570 1.00 94.20 O \\\\nATOM 267 CG LYS A 33 -4.493 6.589 29.163 1.00 94.20 C \\\\nATOM 268 CD LYS A 33 -3.055 6.448 28.644 1.00 94.20 C \\\\nATOM 269 CE LYS A 33 -2.055 6.087 29.746 1.00 94.20 C \\\\nATOM 270 NZ LYS A 33 -0.678 5.970 29.197 1.00 94.20 N \\\\nATOM 271 N ALA A 34 -8.168 7.195 26.262 1.00 95.40 N \\\\nATOM 272 CA ALA A 34 -8.990 7.833 25.229 1.00 95.40 C \\\\nATOM 273 C ALA A 34 -10.354 8.286 25.776 1.00 95.40 C \\\\nATOM 274 CB ALA A 34 -9.158 6.870 24.043 1.00 95.40 C \\\\nATOM 275 O ALA A 34 -10.758 9.432 25.550 1.00 95.40 O \\\\nATOM 276 N VAL A 35 -11.025 7.426 26.551 1.00 96.53 N \\\\nATOM 277 CA VAL A 35 -12.314 7.731 27.196 1.00 96.53 C \\\\nATOM 278 C VAL A 35 -12.135 8.746 28.331 1.00 96.53 C \\\\nATOM 279 CB VAL A 35 -13.021 6.443 27.671 1.00 96.53 C \\\\nATOM 280 O VAL A 35 -12.880 9.723 28.382 1.00 96.53 O \\\\nATOM 281 CG1 VAL A 35 -14.354 6.736 28.371 1.00 96.53 C \\\\nATOM 282 CG2 VAL A 35 -13.342 5.528 26.481 1.00 96.53 C \\\\nATOM 283 N LYS A 36 -11.109 8.614 29.189 1.00 95.17 N \\\\nATOM 284 CA LYS A 36 -10.775 9.626 30.220 1.00 95.17 C \\\\nATOM 285 C LYS A 36 -10.539 11.013 29.600 1.00 95.17 C \\\\nATOM 286 CB LYS A 36 -9.550 9.177 31.053 1.00 95.17 C \\\\nATOM 287 O LYS A 36 -11.017 12.011 30.141 1.00 95.17 O \\\\nATOM 288 CG LYS A 36 -9.892 8.090 32.090 1.00 95.17 C \\\\nATOM 289 CD LYS A 36 -8.669 7.513 32.836 1.00 95.17 C \\\\nATOM 290 CE LYS A 36 -9.134 6.505 33.906 1.00 95.17 C \\\\nATOM 291 NZ LYS A 36 -8.036 5.721 34.536 1.00 95.17 N \\\\nATOM 292 N SER A 37 -9.846 11.077 28.460 1.00 94.09 N \\\\nATOM 293 CA SER A 37 -9.610 12.319 27.710 1.00 94.09 C \\\\nATOM 294 C SER A 37 -10.909 12.918 27.155 1.00 94.09 C \\\\nATOM 295 CB SER A 37 -8.606 12.064 26.581 1.00 94.09 C \\\\nATOM 296 O SER A 37 -11.152 14.114 27.340 1.00 94.09 O \\\\nATOM 297 OG SER A 37 -8.200 13.280 25.982 1.00 94.09 O \\\\nATOM 298 N LEU A 38 -11.783 12.096 26.554 1.00 96.68 N \\\\nATOM 299 CA LEU A 38 -13.076 12.562 26.040 1.00 96.68 C \\\\nATOM 300 C LEU A 38 -13.976 13.088 27.158 1.00 96.68 C \\\\nATOM 301 CB LEU A 38 -13.802 11.447 25.269 1.00 96.68 C \\\\nATOM 302 O LEU A 38 -14.448 14.217 27.080 1.00 96.68 O \\\\nATOM 303 CG LEU A 38 -15.076 11.947 24.555 1.00 96.68 C \\\\nATOM 304 CD1 LEU A 38 -14.806 13.050 23.532 1.00 96.68 C \\\\nATOM 305 CD2 LEU A 38 -15.755 10.790 23.841 1.00 96.68 C \\\\nATOM 306 N VAL A 39 -14.156 12.316 28.232 1.00 96.49 N \\\\nATOM 307 CA VAL A 39 -14.986 12.708 29.382 1.00 96.49 C \\\\nATOM 308 C VAL A 39 -14.498 14.033 29.979 1.00 96.49 C \\\\nATOM 309 CB VAL A 39 -15.018 11.573 30.428 1.00 96.49 C \\\\nATOM 310 O VAL A 39 -15.314 14.888 30.311 1.00 96.49 O \\\\nATOM 311 CG1 VAL A 39 -15.682 11.974 31.753 1.00 96.49 C \\\\nATOM 312 CG2 VAL A 39 -15.792 10.365 29.885 1.00 96.49 C \\\\nATOM 313 N LYS A 40 -13.179 14.271 30.054 1.00 94.22 N \\\\nATOM 314 CA LYS A 40 -12.625 15.559 30.512 1.00 94.22 C \\\\nATOM 315 C LYS A 40 -12.964 16.731 29.576 1.00 94.22 C \\\\nATOM 316 CB LYS A 40 -11.106 15.419 30.726 1.00 94.22 C \\\\nATOM 317 O LYS A 40 -13.098 17.851 30.064 1.00 94.22 O \\\\nATOM 318 CG LYS A 40 -10.491 16.668 31.386 1.00 94.22 C \\\\nATOM 319 CD LYS A 40 -8.990 16.506 31.663 1.00 94.22 C \\\\nATOM 320 CE LYS A 40 -8.447 17.779 32.331 1.00 94.22 C \\\\nATOM 321 NZ LYS A 40 -6.997 17.680 32.651 1.00 94.22 N \\\\nATOM 322 N LYS A 41 -13.090 16.499 28.263 1.00 94.36 N \\\\nATOM 323 CA LYS A 41 -13.530 17.509 27.283 1.00 94.36 C \\\\nATOM 324 C LYS A 41 -15.037 17.759 27.391 1.00 94.36 C \\\\nATOM 325 CB LYS A 41 -13.121 17.098 25.856 1.00 94.36 C \\\\nATOM 326 O LYS A 41 -15.428 18.897 27.622 1.00 94.36 O \\\\nATOM 327 CG LYS A 41 -11.608 17.217 25.604 1.00 94.36 C \\\\nATOM 328 CD LYS A 41 -11.234 16.547 24.272 1.00 94.36 C \\\\nATOM 329 CE LYS A 41 -9.768 16.770 23.874 1.00 94.36 C \\\\nATOM 330 NZ LYS A 41 -9.555 18.101 23.243 1.00 94.36 N \\\\nATOM 331 N LEU A 42 -15.862 16.712 27.337 1.00 96.39 N \\\\nATOM 332 CA LEU A 42 -17.328 16.840 27.334 1.00 96.39 C \\\\nATOM 333 C LEU A 42 -17.905 17.358 28.660 1.00 96.39 C \\\\nATOM 334 CB LEU A 42 -17.979 15.506 26.942 1.00 96.39 C \\\\nATOM 335 O LEU A 42 -18.942 18.012 28.663 1.00 96.39 O \\\\nATOM 336 CG LEU A 42 -17.544 14.942 25.578 1.00 96.39 C \\\\nATOM 337 CD1 LEU A 42 -18.333 13.665 25.325 1.00 96.39 C \\\\nATOM 338 CD2 LEU A 42 -17.753 15.890 24.400 1.00 96.39 C \\\\nATOM 339 N LYS A 43 -17.206 17.166 29.789 1.00 94.30 N \\\\nATOM 340 CA LYS A 43 -17.544 17.844 31.055 1.00 94.30 C \\\\nATOM 341 C LYS A 43 -17.469 19.373 30.981 1.00 94.30 C \\\\nATOM 342 CB LYS A 43 -16.642 17.354 32.200 1.00 94.30 C \\\\nATOM 343 O LYS A 43 -18.084 20.024 31.814 1.00 94.30 O \\\\nATOM 344 CG LYS A 43 -17.148 16.032 32.779 1.00 94.30 C \\\\nATOM 345 CD LYS A 43 -16.408 15.665 34.067 1.00 94.30 C \\\\nATOM 346 CE LYS A 43 -17.047 14.403 34.653 1.00 94.30 C \\\\nATOM 347 NZ LYS A 43 -16.722 14.247 36.092 1.00 94.30 N \\\\nATOM 348 N LYS A 44 -16.711 19.943 30.036 1.00 92.38 N \\\\nATOM 349 CA LYS A 44 -16.640 21.398 29.828 1.00 92.38 C \\\\nATOM 350 C LYS A 44 -17.732 21.922 28.893 1.00 92.38 C \\\\nATOM 351 CB LYS A 44 -15.269 21.811 29.280 1.00 92.38 C \\\\nATOM 352 O LYS A 44 -18.091 23.083 29.018 1.00 92.38 O \\\\nATOM 353 CG LYS A 44 -14.102 21.511 30.230 1.00 92.38 C \\\\nATOM 354 CD LYS A 44 -12.836 22.153 29.652 1.00 92.38 C \\\\nATOM 355 CE LYS A 44 -11.666 22.080 30.633 1.00 92.38 C \\\\nATOM 356 NZ LYS A 44 -10.614 23.058 30.251 1.00 92.38 N \\\\nATOM 357 N THR A 45 -18.227 21.093 27.971 1.00 92.89 N \\\\nATOM 358 CA THR A 45 -19.252 21.469 26.979 1.00 92.89 C \\\\nATOM 359 C THR A 45 -20.670 21.042 27.372 1.00 92.89 C \\\\nATOM 360 CB THR A 45 -18.919 20.901 25.588 1.00 92.89 C \\\\nATOM 361 O THR A 45 -21.625 21.418 26.705 1.00 92.89 O \\\\nATOM 362 CG2 THR A 45 -17.564 21.381 25.065 1.00 92.89 C \\\\nATOM 363 OG1 THR A 45 -18.867 19.493 25.628 1.00 92.89 O \\\\nATOM 364 N GLY A 46 -20.830 20.240 28.431 1.00 94.57 N \\\\nATOM 365 CA GLY A 46 -22.132 19.732 28.886 1.00 94.57 C \\\\nATOM 366 C GLY A 46 -22.679 18.545 28.078 1.00 94.57 C \\\\nATOM 367 O GLY A 46 -23.735 18.020 28.403 1.00 94.57 O \\\\nATOM 368 N GLN A 47 -21.958 18.059 27.064 1.00 96.14 N \\\\nATOM 369 CA GLN A 47 -22.416 16.991 26.154 1.00 96.14 C \\\\nATOM 370 C GLN A 47 -22.206 15.561 26.691 1.00 96.14 C \\\\nATOM 371 CB GLN A 47 -21.702 17.166 24.809 1.00 96.14 C \\\\nATOM 372 O GLN A 47 -22.330 14.589 25.945 1.00 96.14 O \\\\nATOM 373 CG GLN A 47 -22.141 18.419 24.037 1.00 96.14 C \\\\nATOM 374 CD GLN A 47 -21.126 18.755 22.955 1.00 96.14 C \\\\nATOM 375 NE2 GLN A 47 -21.521 18.931 21.715 1.00 96.14 N \\\\nATOM 376 OE1 GLN A 47 -19.939 18.835 23.226 1.00 96.14 O \\\\nATOM 377 N LEU A 48 -21.836 15.397 27.964 1.00 95.75 N \\\\nATOM 378 CA LEU A 48 -21.485 14.086 28.519 1.00 95.75 C \\\\nATOM 379 C LEU A 48 -22.686 13.127 28.579 1.00 95.75 C \\\\nATOM 380 CB LEU A 48 -20.831 14.306 29.891 1.00 95.75 C \\\\nATOM 381 O LEU A 48 -22.535 11.949 28.255 1.00 95.75 O \\\\nATOM 382 CG LEU A 48 -20.337 13.019 30.577 1.00 95.75 C \\\\nATOM 383 CD1 LEU A 48 -19.330 12.230 29.733 1.00 95.75 C \\\\nATOM 384 CD2 LEU A 48 -19.630 13.420 31.875 1.00 95.75 C \\\\nATOM 385 N ASP A 49 -23.866 13.642 28.922 1.00 95.20 N \\\\nATOM 386 CA ASP A 49 -25.095 12.846 29.016 1.00 95.20 C \\\\nATOM 387 C ASP A 49 -25.645 12.495 27.624 1.00 95.20 C \\\\nATOM 388 CB ASP A 49 -26.134 13.605 29.858 1.00 95.20 C \\\\nATOM 389 O ASP A 49 -26.134 11.388 27.407 1.00 95.20 O \\\\nATOM 390 CG ASP A 49 -25.631 13.965 31.265 1.00 95.20 C \\\\nATOM 391 OD1 ASP A 49 -24.765 13.233 31.800 1.00 95.20 O \\\\nATOM 392 OD2 ASP A 49 -26.072 15.015 31.774 1.00 95.20 O \\\\nATOM 393 N GLU A 50 -25.483 13.388 26.638 1.00 95.50 N \\\\nATOM 394 CA GLU A 50 -25.808 13.097 25.234 1.00 95.50 C \\\\nATOM 395 C GLU A 50 -24.863 12.031 24.649 1.00 95.50 C \\\\nATOM 396 CB GLU A 50 -25.787 14.382 24.385 1.00 95.50 C \\\\nATOM 397 O GLU A 50 -25.313 11.192 23.870 1.00 95.50 O \\\\nATOM 398 CG GLU A 50 -26.900 15.395 24.714 1.00 95.50 C \\\\nATOM 399 CD GLU A 50 -28.309 15.049 24.181 1.00 95.50 C \\\\nATOM 400 OE1 GLU A 50 -29.188 15.943 24.269 1.00 95.50 O \\\\nATOM 401 OE2 GLU A 50 -28.551 13.943 23.643 1.00 95.50 O \\\\nATOM 402 N LEU A 51 -23.579 11.987 25.051 1.00 96.84 N \\\\nATOM 403 CA LEU A 51 -22.690 10.876 24.681 1.00 96.84 C \\\\nATOM 404 C LEU A 51 -23.177 9.565 25.306 1.00 96.84 C \\\\nATOM 405 CB LEU A 51 -21.223 11.158 25.072 1.00 96.84 C \\\\nATOM 406 O LEU A 51 -23.258 8.559 24.608 1.00 96.84 O \\\\nATOM 407 CG LEU A 51 -20.286 9.951 24.816 1.00 96.84 C \\\\nATOM 408 CD1 LEU A 51 -20.083 9.664 23.326 1.00 96.84 C \\\\nATOM 409 CD2 LEU A 51 -18.912 10.170 25.444 1.00 96.84 C \\\\nATOM 410 N GLU A 52 -23.492 9.552 26.604 1.00 95.89 N \\\\nATOM 411 CA GLU A 52 -23.990 8.338 27.260 1.00 95.89 C \\\\nATOM 412 C GLU A 52 -25.289 7.842 26.603 1.00 95.89 C \\\\nATOM 413 CB GLU A 52 -24.130 8.559 28.777 1.00 95.89 C \\\\nATOM 414 O GLU A 52 -25.407 6.653 26.302 1.00 95.89 O \\\\nATOM 415 CG GLU A 52 -24.640 7.275 29.454 1.00 95.89 C \\\\nATOM 416 CD GLU A 52 -24.390 7.180 30.966 1.00 95.89 C \\\\nATOM 417 OE1 GLU A 52 -24.482 6.043 31.488 1.00 95.89 O \\\\nATOM 418 OE2 GLU A 52 -24.034 8.174 31.642 1.00 95.89 O \\\\nATOM 419 N LYS A 53 -26.214 8.750 26.274 1.00 96.28 N \\\\nATOM 420 CA LYS A 53 -27.424 8.464 25.493 1.00 96.28 C \\\\nATOM 421 C LYS A 53 -27.110 7.912 24.098 1.00 96.28 C \\\\nATOM 422 CB LYS A 53 -28.249 9.752 25.426 1.00 96.28 C \\\\nATOM 423 O LYS A 53 -27.704 6.910 23.710 1.00 96.28 O \\\\nATOM 424 CG LYS A 53 -29.588 9.592 24.694 1.00 96.28 C \\\\nATOM 425 CD LYS A 53 -30.278 10.958 24.673 1.00 96.28 C \\\\nATOM 426 CE LYS A 53 -31.551 10.955 23.829 1.00 96.28 C \\\\nATOM 427 NZ LYS A 53 -32.033 12.348 23.670 1.00 96.28 N \\\\nATOM 428 N ALA A 54 -26.183 8.509 23.347 1.00 96.62 N \\\\nATOM 429 CA ALA A 54 -25.789 8.024 22.020 1.00 96.62 C \\\\nATOM 430 C ALA A 54 -25.207 6.605 22.072 1.00 96.62 C \\\\nATOM 431 CB ALA A 54 -24.807 9.023 21.396 1.00 96.62 C \\\\nATOM 432 O ALA A 54 -25.616 5.742 21.298 1.00 96.62 O \\\\nATOM 433 N ILE A 55 -24.307 6.335 23.022 1.00 96.30 N \\\\nATOM 434 CA ILE A 55 -23.681 5.018 23.186 1.00 96.30 C \\\\nATOM 435 C ILE A 55 -24.688 3.949 23.637 1.00 96.30 C \\\\nATOM 436 CB ILE A 55 -22.447 5.125 24.110 1.00 96.30 C \\\\nATOM 437 O ILE A 55 -24.665 2.845 23.099 1.00 96.30 O \\\\nATOM 438 CG1 ILE A 55 -21.331 6.033 23.539 1.00 96.30 C \\\\nATOM 439 CG2 ILE A 55 -21.849 3.744 24.414 1.00 96.30 C \\\\nATOM 440 CD1 ILE A 55 -20.863 5.722 22.113 1.00 96.30 C \\\\nATOM 441 N THR A 56 -25.581 4.270 24.577 1.00 95.54 N \\\\nATOM 442 CA THR A 56 -26.559 3.307 25.119 1.00 95.54 C \\\\nATOM 443 C THR A 56 -27.722 3.023 24.169 1.00 95.54 C \\\\nATOM 444 CB THR A 56 -27.124 3.769 26.470 1.00 95.54 C \\\\nATOM 445 O THR A 56 -28.125 1.871 24.038 1.00 95.54 O \\\\nATOM 446 CG2 THR A 56 -26.083 3.724 27.588 1.00 95.54 C \\\\nATOM 447 OG1 THR A 56 -27.596 5.093 26.403 1.00 95.54 O \\\\nATOM 448 N THR A 57 -28.254 4.044 23.488 1.00 95.70 N \\\\nATOM 449 CA THR A 57 -29.405 3.891 22.573 1.00 95.70 C \\\\nATOM 450 C THR A 57 -29.015 3.477 21.157 1.00 95.70 C \\\\nATOM 451 CB THR A 57 -30.266 5.160 22.486 1.00 95.70 C \\\\nATOM 452 O THR A 57 -29.880 3.040 20.404 1.00 95.70 O \\\\nATOM 453 CG2 THR A 57 -30.814 5.604 23.842 1.00 95.70 C \\\\nATOM 454 OG1 THR A 57 -29.544 6.240 21.937 1.00 95.70 O \\\\nATOM 455 N GLN A 58 -27.740 3.634 20.781 1.00 94.54 N \\\\nATOM 456 CA GLN A 58 -27.207 3.349 19.440 1.00 94.54 C \\\\nATOM 457 C GLN A 58 -27.936 4.101 18.305 1.00 94.54 C \\\\nATOM 458 CB GLN A 58 -27.084 1.828 19.211 1.00 94.54 C \\\\nATOM 459 O GLN A 58 -27.935 3.680 17.149 1.00 94.54 O \\\\nATOM 460 CG GLN A 58 -26.407 1.116 20.396 1.00 94.54 C \\\\nATOM 461 CD GLN A 58 -26.008 -0.329 20.117 1.00 94.54 C \\\\nATOM 462 NE2 GLN A 58 -25.957 -1.152 21.140 1.00 94.54 N \\\\nATOM 463 OE1 GLN A 58 -25.721 -0.762 19.012 1.00 94.54 O \\\\nATOM 464 N ASN A 59 -28.581 5.224 18.639 1.00 92.87 N \\\\nATOM 465 CA ASN A 59 -29.505 5.929 17.759 1.00 92.87 C \\\\nATOM 466 C ASN A 59 -28.807 7.069 16.998 1.00 92.87 C \\\\nATOM 467 CB ASN A 59 -30.705 6.378 18.611 1.00 92.87 C \\\\nATOM 468 O ASN A 59 -28.278 8.009 17.602 1.00 92.87 O \\\\nATOM 469 CG ASN A 59 -31.841 7.012 17.826 1.00 92.87 C \\\\nATOM 470 ND2 ASN A 59 -32.980 7.188 18.452 1.00 92.87 N \\\\nATOM 471 OD1 ASN A 59 -31.741 7.366 16.661 1.00 92.87 O \\\\nATOM 472 N VAL A 60 -28.870 7.013 15.664 1.00 93.35 N \\\\nATOM 473 CA VAL A 60 -28.315 8.020 14.739 1.00 93.35 C \\\\nATOM 474 C VAL A 60 -28.921 9.418 14.934 1.00 93.35 C \\\\nATOM 475 CB VAL A 60 -28.468 7.567 13.270 1.00 93.35 C \\\\nATOM 476 O VAL A 60 -28.242 10.414 14.707 1.00 93.35 O \\\\nATOM 477 CG1 VAL A 60 -27.803 6.203 13.031 1.00 93.35 C \\\\nATOM 478 CG2 VAL A 60 -29.931 7.460 12.812 1.00 93.35 C \\\\nATOM 479 N ASN A 61 -30.156 9.502 15.441 1.00 95.00 N \\\\nATOM 480 CA ASN A 61 -30.888 10.750 15.696 1.00 95.00 C \\\\nATOM 481 C ASN A 61 -30.514 11.426 17.033 1.00 95.00 C \\\\nATOM 482 CB ASN A 61 -32.399 10.475 15.611 1.00 95.00 C \\\\nATOM 483 O ASN A 61 -31.206 12.332 17.498 1.00 95.00 O \\\\nATOM 484 CG ASN A 61 -32.808 9.842 14.297 1.00 95.00 C \\\\nATOM 485 ND2 ASN A 61 -33.213 8.595 14.305 1.00 95.00 N \\\\nATOM 486 OD1 ASN A 61 -32.733 10.444 13.246 1.00 95.00 O \\\\nATOM 487 N THR A 62 -29.454 10.970 17.706 1.00 95.86 N \\\\nATOM 488 CA THR A 62 -28.888 11.690 18.859 1.00 95.86 C \\\\nATOM 489 C THR A 62 -28.145 12.951 18.412 1.00 95.86 C \\\\nATOM 490 CB THR A 62 -28.010 10.785 19.738 1.00 95.86 C \\\\nATOM 491 O THR A 62 -27.816 13.104 17.239 1.00 95.86 O \\\\nATOM 492 CG2 THR A 62 -28.897 9.815 20.518 1.00 95.86 C \\\\nATOM 493 OG1 THR A 62 -27.070 10.038 18.995 1.00 95.86 O \\\\nATOM 494 N LYS A 63 -27.895 13.895 19.330 1.00 96.63 N \\\\nATOM 495 CA LYS A 63 -27.209 15.154 18.992 1.00 96.63 C \\\\nATOM 496 C LYS A 63 -25.744 14.921 18.605 1.00 96.63 C \\\\nATOM 497 CB LYS A 63 -27.314 16.159 20.148 1.00 96.63 C \\\\nATOM 498 O LYS A 63 -25.135 13.909 18.967 1.00 96.63 O \\\\nATOM 499 CG LYS A 63 -28.758 16.609 20.412 1.00 96.63 C \\\\nATOM 500 CD LYS A 63 -28.768 17.696 21.493 1.00 96.63 C \\\\nATOM 501 CE LYS A 63 -30.200 17.996 21.951 1.00 96.63 C \\\\nATOM 502 NZ LYS A 63 -30.233 18.277 23.405 1.00 96.63 N \\\\nATOM 503 N CYS A 64 -25.151 15.889 17.906 1.00 97.45 N \\\\nATOM 504 CA CYS A 64 -23.708 15.899 17.689 1.00 97.45 C \\\\nATOM 505 C CYS A 64 -22.976 16.013 19.035 1.00 97.45 C \\\\nATOM 506 CB CYS A 64 -23.301 17.032 16.736 1.00 97.45 C \\\\nATOM 507 O CYS A 64 -23.277 16.878 19.859 1.00 97.45 O \\\\nATOM 508 SG CYS A 64 -23.929 16.730 15.059 1.00 97.45 S \\\\nATOM 509 N ILE A 65 -21.986 15.145 19.238 1.00 97.88 N \\\\nATOM 510 CA ILE A 65 -21.057 15.214 20.369 1.00 97.88 C \\\\nATOM 511 C ILE A 65 -19.784 15.843 19.833 1.00 97.88 C \\\\nATOM 512 CB ILE A 65 -20.803 13.809 20.959 1.00 97.88 C \\\\nATOM 513 O ILE A 65 -19.086 15.193 19.059 1.00 97.88 O \\\\nATOM 514 CG1 ILE A 65 -22.099 13.076 21.362 1.00 97.88 C \\\\nATOM 515 CG2 ILE A 65 -19.845 13.902 22.156 1.00 97.88 C \\\\nATOM 516 CD1 ILE A 65 -23.002 13.838 22.332 1.00 97.88 C \\\\nATOM 517 N THR A 66 -19.495 17.093 20.178 1.00 97.50 N \\\\nATOM 518 CA THR A 66 -18.403 17.848 19.556 1.00 97.50 C \\\\nATOM 519 C THR A 66 -17.161 17.943 20.436 1.00 97.50 C \\\\nATOM 520 CB THR A 66 -18.853 19.226 19.043 1.00 97.50 C \\\\nATOM 521 O THR A 66 -17.208 17.860 21.663 1.00 97.50 O \\\\nATOM 522 CG2 THR A 66 -19.826 19.092 17.873 1.00 97.50 C \\\\nATOM 523 OG1 THR A 66 -19.484 20.007 20.020 1.00 97.50 O \\\\nATOM 524 N ILE A 67 -16.002 18.076 19.789 1.00 96.58 N \\\\nATOM 525 CA ILE A 67 -14.770 18.550 20.423 1.00 96.58 C \\\\nATOM 526 C ILE A 67 -14.099 19.604 19.526 1.00 96.58 C \\\\nATOM 527 CB ILE A 67 -13.795 17.398 20.776 1.00 96.58 C \\\\nATOM 528 O ILE A 67 -14.213 19.500 18.301 1.00 96.58 O \\\\nATOM 529 CG1 ILE A 67 -13.241 16.667 19.533 1.00 96.58 C \\\\nATOM 530 CG2 ILE A 67 -14.426 16.406 21.772 1.00 96.58 C \\\\nATOM 531 CD1 ILE A 67 -12.138 15.653 19.860 1.00 96.58 C \\\\nATOM 532 N PRO A 68 -13.321 20.546 20.093 1.00 95.38 N \\\\nATOM 533 CA PRO A 68 -12.526 21.483 19.303 1.00 95.38 C \\\\nATOM 534 C PRO A 68 -11.526 20.769 18.386 1.00 95.38 C \\\\nATOM 535 CB PRO A 68 -11.821 22.392 20.315 1.00 95.38 C \\\\nATOM 536 O PRO A 68 -10.821 19.845 18.818 1.00 95.38 O \\\\nATOM 537 CG PRO A 68 -12.757 22.354 21.521 1.00 95.38 C \\\\nATOM 538 CD PRO A 68 -13.292 20.923 21.498 1.00 95.38 C \\\\nATOM 539 N ARG A 69 -11.451 21.219 17.131 1.00 95.13 N \\\\nATOM 540 CA ARG A 69 -10.511 20.757 16.106 1.00 95.13 C \\\\nATOM 541 C ARG A 69 -9.103 21.296 16.394 1.00 95.13 C \\\\nATOM 542 CB ARG A 69 -11.061 21.203 14.735 1.00 95.13 C \\\\nATOM 543 O ARG A 69 -8.932 22.446 16.781 1.00 95.13 O \\\\nATOM 544 CG ARG A 69 -10.229 20.703 13.544 1.00 95.13 C \\\\nATOM 545 CD ARG A 69 -10.828 21.090 12.187 1.00 95.13 C \\\\nATOM 546 NE ARG A 69 -12.138 20.456 11.968 1.00 95.13 N \\\\nATOM 547 NH1 ARG A 69 -11.563 18.720 10.567 1.00 95.13 N \\\\nATOM 548 NH2 ARG A 69 -13.693 19.061 11.108 1.00 95.13 N \\\\nATOM 549 CZ ARG A 69 -12.449 19.415 11.226 1.00 95.13 C \\\\nATOM 550 N SER A 70 -8.076 20.463 16.218 1.00 93.69 N \\\\nATOM 551 CA SER A 70 -6.675 20.911 16.235 1.00 93.69 C \\\\nATOM 552 C SER A 70 -6.253 21.450 14.865 1.00 93.69 C \\\\nATOM 553 CB SER A 70 -5.742 19.766 16.648 1.00 93.69 C \\\\nATOM 554 O SER A 70 -6.850 21.094 13.851 1.00 93.69 O \\\\nATOM 555 OG SER A 70 -5.823 18.716 15.711 1.00 93.69 O \\\\nATOM 556 N LEU A 71 -5.163 22.222 14.818 1.00 90.27 N \\\\nATOM 557 CA LEU A 71 -4.580 22.745 13.570 1.00 90.27 C \\\\nATOM 558 C LEU A 71 -4.316 21.657 12.507 1.00 90.27 C \\\\nATOM 559 CB LEU A 71 -3.256 23.464 13.900 1.00 90.27 C \\\\nATOM 560 O LEU A 71 -4.434 21.918 11.318 1.00 90.27 O \\\\nATOM 561 CG LEU A 71 -3.372 24.686 14.832 1.00 90.27 C \\\\nATOM 562 CD1 LEU A 71 -1.974 25.203 15.173 1.00 90.27 C \\\\nATOM 563 CD2 LEU A 71 -4.171 25.824 14.201 1.00 90.27 C \\\\nATOM 564 N ASP A 72 -3.990 20.431 12.932 1.00 89.02 N \\\\nATOM 565 CA ASP A 72 -3.747 19.272 12.060 1.00 89.02 C \\\\nATOM 566 C ASP A 72 -4.926 18.276 11.996 1.00 89.02 C \\\\nATOM 567 CB ASP A 72 -2.433 18.589 12.485 1.00 89.02 C \\\\nATOM 568 O ASP A 72 -4.781 17.172 11.472 1.00 89.02 O \\\\nATOM 569 CG ASP A 72 -2.514 17.778 13.788 1.00 89.02 C \\\\nATOM 570 OD1 ASP A 72 -3.458 17.970 14.592 1.00 89.02 O \\\\nATOM 571 OD2 ASP A 72 -1.606 16.927 13.988 1.00 89.02 O \\\\nATOM 572 N GLY A 73 -6.075 18.615 12.589 1.00 90.68 N \\\\nATOM 573 CA GLY A 73 -7.268 17.767 12.680 1.00 90.68 C \\\\nATOM 574 C GLY A 73 -7.142 16.496 13.539 1.00 90.68 C \\\\nATOM 575 O GLY A 73 -8.121 15.751 13.646 1.00 90.68 O \\\\nATOM 576 N ARG A 74 -5.982 16.216 14.152 1.00 92.97 N \\\\nATOM 577 CA ARG A 74 -5.710 14.993 14.927 1.00 92.97 C \\\\nATOM 578 C ARG A 74 -5.775 15.211 16.439 1.00 92.97 C \\\\nATOM 579 CB ARG A 74 -4.347 14.404 14.541 1.00 92.97 C \\\\nATOM 580 O ARG A 74 -5.153 16.105 17.007 1.00 92.97 O \\\\nATOM 581 CG ARG A 74 -4.292 13.941 13.076 1.00 92.97 C \\\\nATOM 582 CD ARG A 74 -2.922 13.364 12.704 1.00 92.97 C \\\\nATOM 583 NE ARG A 74 -1.854 14.364 12.867 1.00 92.97 N \\\\nATOM 584 NH1 ARG A 74 -0.127 13.265 11.816 1.00 92.97 N \\\\nATOM 585 NH2 ARG A 74 0.142 15.350 12.593 1.00 92.97 N \\\\nATOM 586 CZ ARG A 74 -0.619 14.312 12.419 1.00 92.97 C \\\\nATOM 587 N LEU A 75 -6.436 14.284 17.124 1.00 94.38 N \\\\nATOM 588 CA LEU A 75 -6.420 14.175 18.577 1.00 94.38 C \\\\nATOM 589 C LEU A 75 -5.216 13.339 19.036 1.00 94.38 C \\\\nATOM 590 CB LEU A 75 -7.766 13.584 19.026 1.00 94.38 C \\\\nATOM 591 O LEU A 75 -4.989 12.231 18.547 1.00 94.38 O \\\\nATOM 592 CG LEU A 75 -7.917 13.386 20.543 1.00 94.38 C \\\\nATOM 593 CD1 LEU A 75 -7.888 14.711 21.312 1.00 94.38 C \\\\nATOM 594 CD2 LEU A 75 -9.250 12.703 20.838 1.00 94.38 C \\\\nATOM 595 N GLN A 76 -4.470 13.843 20.021 1.00 93.91 N \\\\nATOM 596 CA GLN A 76 -3.434 13.075 20.711 1.00 93.91 C \\\\nATOM 597 C GLN A 76 -4.001 12.383 21.959 1.00 93.91 C \\\\nATOM 598 CB GLN A 76 -2.228 13.973 21.025 1.00 93.91 C \\\\nATOM 599 O GLN A 76 -4.605 13.023 22.821 1.00 93.91 O \\\\nATOM 600 CG GLN A 76 -1.059 13.148 21.595 1.00 93.91 C \\\\nATOM 601 CD GLN A 76 0.254 13.919 21.672 1.00 93.91 C \\\\nATOM 602 NE2 GLN A 76 1.165 13.490 22.517 1.00 93.91 N \\\\nATOM 603 OE1 GLN A 76 0.496 14.875 20.951 1.00 93.91 O \\\\nATOM 604 N VAL A 77 -3.755 11.077 22.078 1.00 91.95 N \\\\nATOM 605 CA VAL A 77 -4.080 10.257 23.252 1.00 91.95 C \\\\nATOM 606 C VAL A 77 -2.822 9.505 23.690 1.00 91.95 C \\\\nATOM 607 CB VAL A 77 -5.244 9.286 22.969 1.00 91.95 C \\\\nATOM 608 O VAL A 77 -2.366 8.565 23.031 1.00 91.95 O \\\\nATOM 609 CG1 VAL A 77 -5.582 8.478 24.229 1.00 91.95 C \\\\nATOM 610 CG2 VAL A 77 -6.518 10.015 22.520 1.00 91.95 C \\\\nATOM 611 N SER A 78 -2.256 9.910 24.831 1.00 89.64 N \\\\nATOM 612 CA SER A 78 -0.940 9.453 25.304 1.00 89.64 C \\\\nATOM 613 C SER A 78 0.139 9.719 24.234 1.00 89.64 C \\\\nATOM 614 CB SER A 78 -1.034 7.999 25.813 1.00 89.64 C \\\\nATOM 615 O SER A 78 0.383 10.877 23.894 1.00 89.64 O \\\\nATOM 616 OG SER A 78 -0.107 7.700 26.853 1.00 89.64 O \\\\nATOM 617 N HIS A 79 0.750 8.669 23.679 1.00 87.62 N \\\\nATOM 618 CA HIS A 79 1.822 8.748 22.677 1.00 87.62 C \\\\nATOM 619 C HIS A 79 1.325 8.524 21.236 1.00 87.62 C \\\\nATOM 620 CB HIS A 79 2.944 7.764 23.061 1.00 87.62 C \\\\nATOM 621 O HIS A 79 2.130 8.502 20.315 1.00 87.62 O \\\\nATOM 622 CG HIS A 79 3.317 7.846 24.520 1.00 87.62 C \\\\nATOM 623 CD2 HIS A 79 2.824 7.047 25.515 1.00 87.62 C \\\\nATOM 624 ND1 HIS A 79 4.077 8.821 25.124 1.00 87.62 N \\\\nATOM 625 CE1 HIS A 79 4.026 8.622 26.453 1.00 87.62 C \\\\nATOM 626 NE2 HIS A 79 3.222 7.582 26.741 1.00 87.62 N \\\\nATOM 627 N ARG A 80 0.011 8.342 21.023 1.00 89.06 N \\\\nATOM 628 CA ARG A 80 -0.589 8.120 19.695 1.00 89.06 C \\\\nATOM 629 C ARG A 80 -1.371 9.360 19.252 1.00 89.06 C \\\\nATOM 630 CB ARG A 80 -1.469 6.850 19.695 1.00 89.06 C \\\\nATOM 631 O ARG A 80 -2.094 9.946 20.059 1.00 89.06 O \\\\nATOM 632 CG ARG A 80 -0.694 5.556 20.025 1.00 89.06 C \\\\nATOM 633 CD ARG A 80 -1.591 4.306 19.924 1.00 89.06 C \\\\nATOM 634 NE ARG A 80 -0.844 3.050 20.173 1.00 89.06 N \\\\nATOM 635 NH1 ARG A 80 -2.641 1.599 20.215 1.00 89.06 N \\\\nATOM 636 NH2 ARG A 80 -0.578 0.789 20.395 1.00 89.06 N \\\\nATOM 637 CZ ARG A 80 -1.357 1.827 20.262 1.00 89.06 C \\\\nATOM 638 N LYS A 81 -1.257 9.740 17.976 1.00 91.08 N \\\\nATOM 639 CA LYS A 81 -2.114 10.740 17.313 1.00 91.08 C \\\\nATOM 640 C LYS A 81 -3.033 10.033 16.320 1.00 91.08 C \\\\nATOM 641 CB LYS A 81 -1.278 11.818 16.596 1.00 91.08 C \\\\nATOM 642 O LYS A 81 -2.574 9.153 15.603 1.00 91.08 O \\\\nATOM 643 CG LYS A 81 -0.553 12.772 17.558 1.00 91.08 C \\\\nATOM 644 CD LYS A 81 0.071 13.948 16.788 1.00 91.08 C \\\\nATOM 645 CE LYS A 81 0.707 14.966 17.745 1.00 91.08 C \\\\nATOM 646 NZ LYS A 81 1.119 16.202 17.030 1.00 91.08 N \\\\nATOM 647 N GLY A 82 -4.296 10.436 16.252 1.00 92.21 N \\\\nATOM 648 CA GLY A 82 -5.266 9.886 15.305 1.00 92.21 C \\\\nATOM 649 C GLY A 82 -6.428 10.841 15.063 1.00 92.21 C \\\\nATOM 650 O GLY A 82 -6.586 11.836 15.770 1.00 92.21 O \\\\nATOM 651 N LEU A 83 -7.242 10.562 14.049 1.00 94.68 N \\\\nATOM 652 CA LEU A 83 -8.426 11.370 13.766 1.00 94.68 C \\\\nATOM 653 C LEU A 83 -9.513 11.089 14.819 1.00 94.68 C \\\\nATOM 654 CB LEU A 83 -8.899 11.097 12.332 1.00 94.68 C \\\\nATOM 655 O LEU A 83 -9.783 9.923 15.107 1.00 94.68 O \\\\nATOM 656 CG LEU A 83 -7.914 11.591 11.254 1.00 94.68 C \\\\nATOM 657 CD1 LEU A 83 -8.412 11.182 9.874 1.00 94.68 C \\\\nATOM 658 CD2 LEU A 83 -7.753 13.111 11.288 1.00 94.68 C \\\\nATOM 659 N PRO A 84 -10.135 12.117 15.424 1.00 96.13 N \\\\nATOM 660 CA PRO A 84 -10.963 11.926 16.613 1.00 96.13 C \\\\nATOM 661 C PRO A 84 -12.207 11.073 16.345 1.00 96.13 C \\\\nATOM 662 CB PRO A 84 -11.291 13.335 17.107 1.00 96.13 C \\\\nATOM 663 O PRO A 84 -12.475 10.141 17.096 1.00 96.13 O \\\\nATOM 664 CG PRO A 84 -11.097 14.233 15.887 1.00 96.13 C \\\\nATOM 665 CD PRO A 84 -9.985 13.531 15.117 1.00 96.13 C \\\\nATOM 666 N HIS A 85 -12.917 11.321 15.245 1.00 96.28 N \\\\nATOM 667 CA HIS A 85 -14.066 10.508 14.841 1.00 96.28 C \\\\nATOM 668 C HIS A 85 -13.681 9.035 14.599 1.00 96.28 C \\\\nATOM 669 CB HIS A 85 -14.733 11.152 13.620 1.00 96.28 C \\\\nATOM 670 O HIS A 85 -14.369 8.151 15.099 1.00 96.28 O \\\\nATOM 671 CG HIS A 85 -13.853 11.227 12.398 1.00 96.28 C \\\\nATOM 672 CD2 HIS A 85 -13.950 10.425 11.294 1.00 96.28 C \\\\nATOM 673 ND1 HIS A 85 -12.801 12.094 12.184 1.00 96.28 N \\\\nATOM 674 CE1 HIS A 85 -12.266 11.799 10.989 1.00 96.28 C \\\\nATOM 675 NE2 HIS A 85 -12.924 10.787 10.421 1.00 96.28 N \\\\nATOM 676 N VAL A 86 -12.538 8.761 13.950 1.00 95.91 N \\\\nATOM 677 CA VAL A 86 -12.007 7.394 13.763 1.00 95.91 C \\\\nATOM 678 C VAL A 86 -11.714 6.721 15.103 1.00 95.91 C \\\\nATOM 679 CB VAL A 86 -10.731 7.378 12.895 1.00 95.91 C \\\\nATOM 680 O VAL A 86 -12.126 5.586 15.305 1.00 95.91 O \\\\nATOM 681 CG1 VAL A 86 -10.186 5.964 12.647 1.00 95.91 C \\\\nATOM 682 CG2 VAL A 86 -10.992 7.999 11.526 1.00 95.91 C \\\\nATOM 683 N ILE A 87 -11.056 7.416 16.041 1.00 95.75 N \\\\nATOM 684 CA ILE A 87 -10.737 6.877 17.378 1.00 95.75 C \\\\nATOM 685 C ILE A 87 -12.005 6.382 18.085 1.00 95.75 C \\\\nATOM 686 CB ILE A 87 -9.989 7.938 18.229 1.00 95.75 C \\\\nATOM 687 O ILE A 87 -12.017 5.278 18.627 1.00 95.75 O \\\\nATOM 688 CG1 ILE A 87 -8.549 8.131 17.697 1.00 95.75 C \\\\nATOM 689 CG2 ILE A 87 -9.975 7.568 19.729 1.00 95.75 C \\\\nATOM 690 CD1 ILE A 87 -7.835 9.374 18.251 1.00 95.75 C \\\\nATOM 691 N TYR A 88 -13.070 7.184 18.078 1.00 97.01 N \\\\nATOM 692 CA TYR A 88 -14.292 6.876 18.820 1.00 97.01 C \\\\nATOM 693 C TYR A 88 -15.236 5.921 18.067 1.00 97.01 C \\\\nATOM 694 CB TYR A 88 -14.923 8.197 19.280 1.00 97.01 C \\\\nATOM 695 O TYR A 88 -15.862 5.073 18.706 1.00 97.01 O \\\\nATOM 696 CG TYR A 88 -14.039 8.958 20.269 1.00 97.01 C \\\\nATOM 697 CD1 TYR A 88 -13.650 8.363 21.488 1.00 97.01 C \\\\nATOM 698 CD2 TYR A 88 -13.542 10.235 19.946 1.00 97.01 C \\\\nATOM 699 CE1 TYR A 88 -12.758 9.025 22.356 1.00 97.01 C \\\\nATOM 700 CE2 TYR A 88 -12.657 10.909 20.809 1.00 97.01 C \\\\nATOM 701 OH TYR A 88 -11.359 10.917 22.833 1.00 97.01 O \\\\nATOM 702 CZ TYR A 88 -12.249 10.297 22.010 1.00 97.01 C \\\\nATOM 703 N CYS A 89 -15.259 5.944 16.728 1.00 97.14 N \\\\nATOM 704 CA CYS A 89 -15.911 4.899 15.927 1.00 97.14 C \\\\nATOM 705 C CYS A 89 -15.223 3.538 16.102 1.00 97.14 C \\\\nATOM 706 CB CYS A 89 -15.940 5.300 14.446 1.00 97.14 C \\\\nATOM 707 O CYS A 89 -15.909 2.531 16.282 1.00 97.14 O \\\\nATOM 708 SG CYS A 89 -17.012 6.741 14.207 1.00 97.14 S \\\\nATOM 709 N ARG A 90 -13.881 3.502 16.131 1.00 94.96 N \\\\nATOM 710 CA ARG A 90 -13.118 2.270 16.374 1.00 94.96 C \\\\nATOM 711 C ARG A 90 -13.416 1.683 17.753 1.00 94.96 C \\\\nATOM 712 CB ARG A 90 -11.610 2.504 16.148 1.00 94.96 C \\\\nATOM 713 O ARG A 90 -13.631 0.485 17.889 1.00 94.96 O \\\\nATOM 714 CG ARG A 90 -10.822 1.179 16.147 1.00 94.96 C \\\\nATOM 715 CD ARG A 90 -9.299 1.349 16.072 1.00 94.96 C \\\\nATOM 716 NE ARG A 90 -8.859 1.913 14.783 1.00 94.96 N \\\\nATOM 717 NH1 ARG A 90 -6.593 1.849 15.128 1.00 94.96 N \\\\nATOM 718 NH2 ARG A 90 -7.394 2.582 13.182 1.00 94.96 N \\\\nATOM 719 CZ ARG A 90 -7.620 2.119 14.376 1.00 94.96 C \\\\nATOM 720 N LEU A 91 -13.475 2.541 18.774 1.00 95.35 N \\\\nATOM 721 CA LEU A 91 -13.684 2.125 20.161 1.00 95.35 C \\\\nATOM 722 C LEU A 91 -15.085 1.529 20.399 1.00 95.35 C \\\\nATOM 723 CB LEU A 91 -13.349 3.325 21.071 1.00 95.35 C \\\\nATOM 724 O LEU A 91 -15.193 0.505 21.071 1.00 95.35 O \\\\nATOM 725 CG LEU A 91 -13.069 2.959 22.541 1.00 95.35 C \\\\nATOM 726 CD1 LEU A 91 -12.143 4.000 23.179 1.00 95.35 C \\\\nATOM 727 CD2 LEU A 91 -14.329 2.914 23.405 1.00 95.35 C \\\\nATOM 728 N TRP A 92 -16.144 2.141 19.854 1.00 96.60 N \\\\nATOM 729 CA TRP A 92 -17.537 1.766 20.157 1.00 96.60 C \\\\nATOM 730 C TRP A 92 -18.284 0.994 19.062 1.00 96.60 C \\\\nATOM 731 CB TRP A 92 -18.313 3.021 20.582 1.00 96.60 C \\\\nATOM 732 O TRP A 92 -19.358 0.464 19.347 1.00 96.60 O \\\\nATOM 733 CG TRP A 92 -17.957 3.535 21.942 1.00 96.60 C \\\\nATOM 734 CD1 TRP A 92 -18.066 2.819 23.082 1.00 96.60 C \\\\nATOM 735 CD2 TRP A 92 -17.462 4.850 22.345 1.00 96.60 C \\\\nATOM 736 CE2 TRP A 92 -17.256 4.832 23.759 1.00 96.60 C \\\\nATOM 737 CE3 TRP A 92 -17.178 6.059 21.672 1.00 96.60 C \\\\nATOM 738 NE1 TRP A 92 -17.647 3.572 24.156 1.00 96.60 N \\\\nATOM 739 CH2 TRP A 92 -16.458 7.112 23.753 1.00 96.60 C \\\\nATOM 740 CZ2 TRP A 92 -16.732 5.930 24.453 1.00 96.60 C \\\\nATOM 741 CZ3 TRP A 92 -16.710 7.188 22.373 1.00 96.60 C \\\\nATOM 742 N ARG A 93 -17.759 0.902 17.831 1.00 95.15 N \\\\nATOM 743 CA ARG A 93 -18.455 0.233 16.712 1.00 95.15 C \\\\nATOM 744 C ARG A 93 -17.601 -0.788 15.968 1.00 95.15 C \\\\nATOM 745 CB ARG A 93 -19.070 1.267 15.755 1.00 95.15 C \\\\nATOM 746 O ARG A 93 -17.990 -1.951 15.932 1.00 95.15 O \\\\nATOM 747 CG ARG A 93 -20.137 2.119 16.462 1.00 95.15 C \\\\nATOM 748 CD ARG A 93 -20.863 3.041 15.485 1.00 95.15 C \\\\nATOM 749 NE ARG A 93 -21.743 2.298 14.563 1.00 95.15 N \\\\nATOM 750 NH1 ARG A 93 -22.348 4.110 13.332 1.00 95.15 N \\\\nATOM 751 NH2 ARG A 93 -23.186 2.127 12.794 1.00 95.15 N \\\\nATOM 752 CZ ARG A 93 -22.420 2.840 13.570 1.00 95.15 C \\\\nATOM 753 N TRP A 94 -16.461 -0.377 15.415 1.00 94.17 N \\\\nATOM 754 CA TRP A 94 -15.676 -1.193 14.474 1.00 94.17 C \\\\nATOM 755 C TRP A 94 -14.194 -1.247 14.882 1.00 94.17 C \\\\nATOM 756 CB TRP A 94 -15.855 -0.623 13.061 1.00 94.17 C \\\\nATOM 757 O TRP A 94 -13.423 -0.380 14.469 1.00 94.17 O \\\\nATOM 758 CG TRP A 94 -17.264 -0.527 12.567 1.00 94.17 C \\\\nATOM 759 CD1 TRP A 94 -18.073 -1.569 12.277 1.00 94.17 C \\\\nATOM 760 CD2 TRP A 94 -18.039 0.675 12.283 1.00 94.17 C \\\\nATOM 761 CE2 TRP A 94 -19.324 0.281 11.803 1.00 94.17 C \\\\nATOM 762 CE3 TRP A 94 -17.778 2.060 12.376 1.00 94.17 C \\\\nATOM 763 NE1 TRP A 94 -19.289 -1.098 11.818 1.00 94.17 N \\\\nATOM 764 CH2 TRP A 94 -19.992 2.588 11.501 1.00 94.17 C \\\\nATOM 765 CZ2 TRP A 94 -20.291 1.216 11.407 1.00 94.17 C \\\\nATOM 766 CZ3 TRP A 94 -18.748 3.008 11.999 1.00 94.17 C \\\\nATOM 767 N PRO A 95 -13.767 -2.218 15.713 1.00 91.85 N \\\\nATOM 768 CA PRO A 95 -12.377 -2.334 16.180 1.00 91.85 C \\\\nATOM 769 C PRO A 95 -11.349 -2.409 15.044 1.00 91.85 C \\\\nATOM 770 CB PRO A 95 -12.335 -3.624 17.007 1.00 91.85 C \\\\nATOM 771 O PRO A 95 -10.232 -1.917 15.177 1.00 91.85 O \\\\nATOM 772 CG PRO A 95 -13.776 -3.784 17.471 1.00 91.85 C \\\\nATOM 773 CD PRO A 95 -14.589 -3.261 16.296 1.00 91.85 C \\\\nATOM 774 N ASP A 96 -11.778 -2.981 13.924 1.00 88.11 N \\\\nATOM 775 CA ASP A 96 -11.075 -3.212 12.665 1.00 88.11 C \\\\nATOM 776 C ASP A 96 -11.137 -2.021 11.684 1.00 88.11 C \\\\nATOM 777 CB ASP A 96 -11.697 -4.475 12.048 1.00 88.11 C \\\\nATOM 778 O ASP A 96 -10.795 -2.157 10.514 1.00 88.11 O \\\\nATOM 779 CG ASP A 96 -13.152 -4.244 11.620 1.00 88.11 C \\\\nATOM 780 OD1 ASP A 96 -13.968 -3.756 12.443 1.00 88.11 O \\\\nATOM 781 OD2 ASP A 96 -13.460 -4.509 10.440 1.00 88.11 O \\\\nATOM 782 N LEU A 97 -11.589 -0.845 12.128 1.00 90.03 N \\\\nATOM 783 CA LEU A 97 -11.603 0.378 11.321 1.00 90.03 C \\\\nATOM 784 C LEU A 97 -10.190 0.968 11.204 1.00 90.03 C \\\\nATOM 785 CB LEU A 97 -12.558 1.369 12.005 1.00 90.03 C \\\\nATOM 786 O LEU A 97 -9.690 1.539 12.177 1.00 90.03 O \\\\nATOM 787 CG LEU A 97 -12.699 2.703 11.262 1.00 90.03 C \\\\nATOM 788 CD1 LEU A 97 -13.601 2.541 10.045 1.00 90.03 C \\\\nATOM 789 CD2 LEU A 97 -13.313 3.751 12.188 1.00 90.03 C \\\\nATOM 790 N HIS A 98 -9.561 0.935 10.034 1.00 83.53 N \\\\nATOM 791 CA HIS A 98 -8.185 1.398 9.822 1.00 83.53 C \\\\nATOM 792 C HIS A 98 -8.109 2.885 9.443 1.00 83.53 C \\\\nATOM 793 CB HIS A 98 -7.491 0.500 8.787 1.00 83.53 C \\\\nATOM 794 O HIS A 98 -7.307 3.624 10.024 1.00 83.53 O \\\\nATOM 795 CG HIS A 98 -7.350 -0.918 9.279 1.00 83.53 C \\\\nATOM 796 CD2 HIS A 98 -6.292 -1.441 9.975 1.00 83.53 C \\\\nATOM 797 ND1 HIS A 98 -8.318 -1.894 9.231 1.00 83.53 N \\\\nATOM 798 CE1 HIS A 98 -7.867 -2.964 9.902 1.00 83.53 C \\\\nATOM 799 NE2 HIS A 98 -6.648 -2.722 10.403 1.00 83.53 N \\\\nATOM 800 N SER A 99 -8.966 3.349 8.528 1.00 85.84 N \\\\nATOM 801 CA SER A 99 -8.930 4.700 7.946 1.00 85.84 C \\\\nATOM 802 C SER A 99 -10.231 5.484 8.140 1.00 85.84 C \\\\nATOM 803 CB SER A 99 -8.601 4.601 6.452 1.00 85.84 C \\\\nATOM 804 O SER A 99 -11.318 4.925 8.226 1.00 85.84 O \\\\nATOM 805 OG SER A 99 -8.411 5.893 5.882 1.00 85.84 O \\\\nATOM 806 N HIS A 100 -10.141 6.818 8.123 1.00 89.28 N \\\\nATOM 807 CA HIS A 100 -11.322 7.683 7.992 1.00 89.28 C \\\\nATOM 808 C HIS A 100 -12.066 7.522 6.664 1.00 89.28 C \\\\nATOM 809 CB HIS A 100 -10.934 9.152 8.163 1.00 89.28 C \\\\nATOM 810 O HIS A 100 -13.252 7.814 6.608 1.00 89.28 O \\\\nATOM 811 CG HIS A 100 -10.106 9.767 7.057 1.00 89.28 C \\\\nATOM 812 CD2 HIS A 100 -10.271 11.039 6.582 1.00 89.28 C \\\\nATOM 813 ND1 HIS A 100 -9.054 9.208 6.355 1.00 89.28 N \\\\nATOM 814 CE1 HIS A 100 -8.602 10.136 5.494 1.00 89.28 C \\\\nATOM 815 NE2 HIS A 100 -9.290 11.280 5.620 1.00 89.28 N \\\\nATOM 816 N HIS A 101 -11.389 7.043 5.617 1.00 87.61 N \\\\nATOM 817 CA HIS A 101 -11.995 6.815 4.305 1.00 87.61 C \\\\nATOM 818 C HIS A 101 -13.023 5.667 4.339 1.00 87.61 C \\\\nATOM 819 CB HIS A 101 -10.877 6.550 3.288 1.00 87.61 C \\\\nATOM 820 O HIS A 101 -13.914 5.620 3.502 1.00 87.61 O \\\\nATOM 821 CG HIS A 101 -9.903 7.679 3.043 1.00 87.61 C \\\\nATOM 822 CD2 HIS A 101 -8.576 7.525 2.753 1.00 87.61 C \\\\nATOM 823 ND1 HIS A 101 -10.253 9.008 2.824 1.00 87.61 N \\\\nATOM 824 CE1 HIS A 101 -9.148 9.614 2.366 1.00 87.61 C \\\\nATOM 825 NE2 HIS A 101 -8.114 8.755 2.330 1.00 87.61 N \\\\nATOM 826 N GLU A 102 -12.947 4.778 5.340 1.00 91.34 N \\\\nATOM 827 CA GLU A 102 -13.962 3.748 5.612 1.00 91.34 C \\\\nATOM 828 C GLU A 102 -15.215 4.320 6.298 1.00 91.34 C \\\\nATOM 829 CB GLU A 102 -13.376 2.657 6.521 1.00 91.34 C \\\\nATOM 830 O GLU A 102 -16.148 3.567 6.567 1.00 91.34 O \\\\nATOM 831 CG GLU A 102 -12.282 1.772 5.924 1.00 91.34 C \\\\nATOM 832 CD GLU A 102 -11.709 0.897 7.044 1.00 91.34 C \\\\nATOM 833 OE1 GLU A 102 -10.610 1.257 7.528 1.00 91.34 O \\\\nATOM 834 OE2 GLU A 102 -12.403 -0.044 7.507 1.00 91.34 O \\\\nATOM 835 N LEU A 103 -15.260 5.621 6.617 1.00 94.44 N \\\\nATOM 836 CA LEU A 103 -16.401 6.278 7.252 1.00 94.44 C \\\\nATOM 837 C LEU A 103 -17.027 7.334 6.336 1.00 94.44 C \\\\nATOM 838 CB LEU A 103 -15.993 6.932 8.583 1.00 94.44 C \\\\nATOM 839 O LEU A 103 -16.368 8.273 5.892 1.00 94.44 O \\\\nATOM 840 CG LEU A 103 -15.497 5.984 9.685 1.00 94.44 C \\\\nATOM 841 CD1 LEU A 103 -15.192 6.821 10.931 1.00 94.44 C \\\\nATOM 842 CD2 LEU A 103 -16.527 4.918 10.060 1.00 94.44 C \\\\nATOM 843 N ARG A 104 -18.346 7.257 6.169 1.00 93.98 N \\\\nATOM 844 CA ARG A 104 -19.178 8.341 5.637 1.00 93.98 C \\\\nATOM 845 C ARG A 104 -19.914 9.007 6.796 1.00 93.98 C \\\\nATOM 846 CB ARG A 104 -20.119 7.758 4.574 1.00 93.98 C \\\\nATOM 847 O ARG A 104 -20.406 8.315 7.679 1.00 93.98 O \\\\nATOM 848 CG ARG A 104 -20.871 8.846 3.792 1.00 93.98 C \\\\nATOM 849 CD ARG A 104 -21.746 8.249 2.682 1.00 93.98 C \\\\nATOM 850 NE ARG A 104 -20.942 7.590 1.630 1.00 93.98 N \\\\nATOM 851 NH1 ARG A 104 -22.690 6.672 0.453 1.00 93.98 N \\\\nATOM 852 NH2 ARG A 104 -20.597 6.298 -0.217 1.00 93.98 N \\\\nATOM 853 CZ ARG A 104 -21.412 6.861 0.631 1.00 93.98 C \\\\nATOM 854 N ALA A 105 -19.987 10.334 6.832 1.00 95.58 N \\\\nATOM 855 CA ALA A 105 -20.825 11.016 7.817 1.00 95.58 C \\\\nATOM 856 C ALA A 105 -22.312 10.886 7.449 1.00 95.58 C \\\\nATOM 857 CB ALA A 105 -20.386 12.473 7.934 1.00 95.58 C \\\\nATOM 858 O ALA A 105 -22.654 10.912 6.269 1.00 95.58 O \\\\nATOM 859 N MET A 106 -23.180 10.771 8.454 1.00 94.73 N \\\\nATOM 860 CA MET A 106 -24.633 10.840 8.263 1.00 94.73 C \\\\nATOM 861 C MET A 106 -25.040 12.262 7.857 1.00 94.73 C \\\\nATOM 862 CB MET A 106 -25.367 10.441 9.556 1.00 94.73 C \\\\nATOM 863 O MET A 106 -24.473 13.227 8.368 1.00 94.73 O \\\\nATOM 864 CG MET A 106 -25.076 9.008 10.024 1.00 94.73 C \\\\nATOM 865 SD MET A 106 -25.501 7.677 8.871 1.00 94.73 S \\\\nATOM 866 CE MET A 106 -27.310 7.807 8.826 1.00 94.73 C \\\\nATOM 867 N GLU A 107 -26.060 12.403 7.010 1.00 93.15 N \\\\nATOM 868 CA GLU A 107 -26.558 13.710 6.533 1.00 93.15 C \\\\nATOM 869 C GLU A 107 -27.026 14.628 7.677 1.00 93.15 C \\\\nATOM 870 CB GLU A 107 -27.710 13.476 5.544 1.00 93.15 C \\\\nATOM 871 O GLU A 107 -26.850 15.841 7.622 1.00 93.15 O \\\\nATOM 872 CG GLU A 107 -27.247 12.693 4.303 1.00 93.15 C \\\\nATOM 873 CD GLU A 107 -28.367 12.438 3.284 1.00 93.15 C \\\\nATOM 874 OE1 GLU A 107 -28.010 11.970 2.181 1.00 93.15 O \\\\nATOM 875 OE2 GLU A 107 -29.546 12.670 3.630 1.00 93.15 O \\\\nATOM 876 N LEU A 108 -27.527 14.035 8.765 1.00 93.69 N \\\\nATOM 877 CA LEU A 108 -27.938 14.715 10.001 1.00 93.69 C \\\\nATOM 878 C LEU A 108 -26.760 15.276 10.835 1.00 93.69 C \\\\nATOM 879 CB LEU A 108 -28.760 13.713 10.841 1.00 93.69 C \\\\nATOM 880 O LEU A 108 -26.981 15.903 11.870 1.00 93.69 O \\\\nATOM 881 CG LEU A 108 -30.059 13.205 10.182 1.00 93.69 C \\\\nATOM 882 CD1 LEU A 108 -30.610 12.023 10.982 1.00 93.69 C \\\\nATOM 883 CD2 LEU A 108 -31.133 14.292 10.122 1.00 93.69 C \\\\nATOM 884 N CYS A 109 -25.503 15.021 10.455 1.00 96.21 N \\\\nATOM 885 CA CYS A 109 -24.330 15.402 11.242 1.00 96.21 C \\\\nATOM 886 C CYS A 109 -23.824 16.809 10.888 1.00 96.21 C \\\\nATOM 887 CB CYS A 109 -23.247 14.332 11.086 1.00 96.21 C \\\\nATOM 888 O CYS A 109 -22.939 16.987 10.050 1.00 96.21 O \\\\nATOM 889 SG CYS A 109 -21.880 14.671 12.240 1.00 96.21 S \\\\nATOM 890 N GLU A 110 -24.309 17.816 11.614 1.00 96.46 N \\\\nATOM 891 CA GLU A 110 -23.943 19.229 11.425 1.00 96.46 C \\\\nATOM 892 C GLU A 110 -22.450 19.545 11.646 1.00 96.46 C \\\\nATOM 893 CB GLU A 110 -24.740 20.085 12.415 1.00 96.46 C \\\\nATOM 894 O GLU A 110 -21.980 20.613 11.249 1.00 96.46 O \\\\nATOM 895 CG GLU A 110 -26.263 19.981 12.271 1.00 96.46 C \\\\nATOM 896 CD GLU A 110 -26.979 20.882 13.289 1.00 96.46 C \\\\nATOM 897 OE1 GLU A 110 -28.101 21.328 12.975 1.00 96.46 O \\\\nATOM 898 OE2 GLU A 110 -26.391 21.128 14.371 1.00 96.46 O \\\\nATOM 899 N PHE A 111 -21.695 18.655 12.297 1.00 97.34 N \\\\nATOM 900 CA PHE A 111 -20.281 18.845 12.653 1.00 97.34 C \\\\nATOM 901 C PHE A 111 -19.386 17.721 12.109 1.00 97.34 C \\\\nATOM 902 CB PHE A 111 -20.146 19.067 14.169 1.00 97.34 C \\\\nATOM 903 O PHE A 111 -18.363 17.375 12.709 1.00 97.34 O \\\\nATOM 904 CG PHE A 111 -20.828 20.321 14.674 1.00 97.34 C \\\\nATOM 905 CD1 PHE A 111 -20.106 21.524 14.784 1.00 97.34 C \\\\nATOM 906 CD2 PHE A 111 -22.187 20.286 15.038 1.00 97.34 C \\\\nATOM 907 CE1 PHE A 111 -20.739 22.681 15.274 1.00 97.34 C \\\\nATOM 908 CE2 PHE A 111 -22.828 21.447 15.497 1.00 97.34 C \\\\nATOM 909 CZ PHE A 111 -22.101 22.642 15.627 1.00 97.34 C \\\\nATOM 910 N ALA A 112 -19.768 17.115 10.985 1.00 95.98 N \\\\nATOM 911 CA ALA A 112 -19.009 16.040 10.359 1.00 95.98 C \\\\nATOM 912 C ALA A 112 -17.552 16.444 10.052 1.00 95.98 C \\\\nATOM 913 CB ALA A 112 -19.760 15.597 9.106 1.00 95.98 C \\\\nATOM 914 O ALA A 112 -17.249 17.588 9.699 1.00 95.98 O \\\\nATOM 915 N PHE A 113 -16.612 15.499 10.184 1.00 93.94 N \\\\nATOM 916 CA PHE A 113 -15.178 15.800 10.078 1.00 93.94 C \\\\nATOM 917 C PHE A 113 -14.775 16.480 8.756 1.00 93.94 C \\\\nATOM 918 CB PHE A 113 -14.367 14.516 10.278 1.00 93.94 C \\\\nATOM 919 O PHE A 113 -13.932 17.385 8.777 1.00 93.94 O \\\\nATOM 920 CG PHE A 113 -12.874 14.717 10.076 1.00 93.94 C \\\\nATOM 921 CD1 PHE A 113 -12.257 14.293 8.882 1.00 93.94 C \\\\nATOM 922 CD2 PHE A 113 -12.103 15.355 11.066 1.00 93.94 C \\\\nATOM 923 CE1 PHE A 113 -10.881 14.503 8.686 1.00 93.94 C \\\\nATOM 924 CE2 PHE A 113 -10.724 15.550 10.880 1.00 93.94 C \\\\nATOM 925 CZ PHE A 113 -10.117 15.137 9.681 1.00 93.94 C \\\\nATOM 926 N ASN A 114 -15.397 16.080 7.643 1.00 91.30 N \\\\nATOM 927 CA ASN A 114 -15.186 16.613 6.295 1.00 91.30 C \\\\nATOM 928 C ASN A 114 -15.691 18.056 6.101 1.00 91.30 C \\\\nATOM 929 CB ASN A 114 -15.829 15.658 5.264 1.00 91.30 C \\\\nATOM 930 O ASN A 114 -15.181 18.738 5.219 1.00 91.30 O \\\\nATOM 931 CG ASN A 114 -17.340 15.517 5.407 1.00 91.30 C \\\\nATOM 932 ND2 ASN A 114 -18.054 15.240 4.344 1.00 91.30 N \\\\nATOM 933 OD1 ASN A 114 -17.887 15.635 6.490 1.00 91.30 O \\\\nATOM 934 N MET A 115 -16.607 18.556 6.941 1.00 93.28 N \\\\nATOM 935 CA MET A 115 -17.109 19.941 6.870 1.00 93.28 C \\\\nATOM 936 C MET A 115 -16.089 20.993 7.338 1.00 93.28 C \\\\nATOM 937 CB MET A 115 -18.397 20.097 7.694 1.00 93.28 C \\\\nATOM 938 O MET A 115 -16.359 22.185 7.245 1.00 93.28 O \\\\nATOM 939 CG MET A 115 -19.531 19.178 7.245 1.00 93.28 C \\\\nATOM 940 SD MET A 115 -21.011 19.386 8.269 1.00 93.28 S \\\\nATOM 941 CE MET A 115 -22.025 20.428 7.188 1.00 93.28 C \\\\nATOM 942 N LYS A 116 -14.933 20.574 7.879 1.00 91.49 N \\\\nATOM 943 CA LYS A 116 -13.805 21.437 8.299 1.00 91.49 C \\\\nATOM 944 C LYS A 116 -14.143 22.582 9.284 1.00 91.49 C \\\\nATOM 945 CB LYS A 116 -13.025 21.940 7.064 1.00 91.49 C \\\\nATOM 946 O LYS A 116 -13.315 23.465 9.464 1.00 91.49 O \\\\nATOM 947 CG LYS A 116 -12.402 20.814 6.222 1.00 91.49 C \\\\nATOM 948 CD LYS A 116 -11.661 21.398 5.012 1.00 91.49 C \\\\nATOM 949 CE LYS A 116 -11.126 20.283 4.104 1.00 91.49 C \\\\nATOM 950 NZ LYS A 116 -10.485 20.836 2.882 1.00 91.49 N \\\\nATOM 951 N LYS A 117 -15.291 22.530 9.975 1.00 94.76 N \\\\nATOM 952 CA LYS A 117 -15.671 23.462 11.058 1.00 94.76 C \\\\nATOM 953 C LYS A 117 -14.675 23.438 12.231 1.00 94.76 C \\\\nATOM 954 CB LYS A 117 -17.094 23.133 11.562 1.00 94.76 C \\\\nATOM 955 O LYS A 117 -13.972 22.443 12.419 1.00 94.76 O \\\\nATOM 956 CG LYS A 117 -18.187 23.326 10.495 1.00 94.76 C \\\\nATOM 957 CD LYS A 117 -19.589 23.130 11.097 1.00 94.76 C \\\\nATOM 958 CE LYS A 117 -20.685 23.404 10.057 1.00 94.76 C \\\\nATOM 959 NZ LYS A 117 -22.042 23.260 10.645 1.00 94.76 N \\\\nATOM 960 N ASP A 118 -14.688 24.484 13.060 1.00 95.42 N \\\\nATOM 961 CA ASP A 118 -13.849 24.625 14.270 1.00 95.42 C \\\\nATOM 962 C ASP A 118 -14.050 23.504 15.300 1.00 95.42 C \\\\nATOM 963 CB ASP A 118 -14.163 25.963 14.953 1.00 95.42 C \\\\nATOM 964 O ASP A 118 -13.168 23.209 16.108 1.00 95.42 O \\\\nATOM 965 CG ASP A 118 -13.874 27.158 14.050 1.00 95.42 C \\\\nATOM 966 OD1 ASP A 118 -12.850 27.096 13.335 1.00 95.42 O \\\\nATOM 967 OD2 ASP A 118 -14.713 28.080 14.050 1.00 95.42 O \\\\nATOM 968 N GLU A 119 -15.197 22.831 15.240 1.00 96.27 N \\\\nATOM 969 CA GLU A 119 -15.482 21.617 15.990 1.00 96.27 C \\\\nATOM 970 C GLU A 119 -15.620 20.390 15.078 1.00 96.27 C \\\\nATOM 971 CB GLU A 119 -16.725 21.802 16.862 1.00 96.27 C \\\\nATOM 972 O GLU A 119 -15.860 20.478 13.870 1.00 96.27 O \\\\nATOM 973 CG GLU A 119 -16.575 22.893 17.932 1.00 96.27 C \\\\nATOM 974 CD GLU A 119 -17.483 22.585 19.128 1.00 96.27 C \\\\nATOM 975 OE1 GLU A 119 -16.925 22.384 20.230 1.00 96.27 O \\\\nATOM 976 OE2 GLU A 119 -18.703 22.390 18.922 1.00 96.27 O \\\\nATOM 977 N VAL A 120 -15.467 19.208 15.673 1.00 96.95 N \\\\nATOM 978 CA VAL A 120 -15.663 17.914 15.015 1.00 96.95 C \\\\nATOM 979 C VAL A 120 -16.561 17.015 15.856 1.00 96.95 C \\\\nATOM 980 CB VAL A 120 -14.313 17.253 14.669 1.00 96.95 C \\\\nATOM 981 O VAL A 120 -16.314 16.811 17.046 1.00 96.95 O \\\\nATOM 982 CG1 VAL A 120 -13.321 17.164 15.838 1.00 96.95 C \\\\nATOM 983 CG2 VAL A 120 -14.496 15.836 14.107 1.00 96.95 C \\\\nATOM 984 N CYS A 121 -17.576 16.433 15.216 1.00 97.92 N \\\\nATOM 985 CA CYS A 121 -18.431 15.420 15.813 1.00 97.92 C \\\\nATOM 986 C CYS A 121 -17.659 14.112 16.029 1.00 97.92 C \\\\nATOM 987 CB CYS A 121 -19.679 15.186 14.954 1.00 97.92 C \\\\nATOM 988 O CYS A 121 -17.033 13.574 15.111 1.00 97.92 O \\\\nATOM 989 SG CYS A 121 -20.832 14.159 15.908 1.00 97.92 S \\\\nATOM 990 N VAL A 122 -17.752 13.582 17.243 1.00 97.72 N \\\\nATOM 991 CA VAL A 122 -17.203 12.298 17.686 1.00 97.72 C \\\\nATOM 992 C VAL A 122 -18.285 11.307 18.125 1.00 97.72 C \\\\nATOM 993 CB VAL A 122 -16.141 12.495 18.782 1.00 97.72 C \\\\nATOM 994 O VAL A 122 -17.956 10.257 18.673 1.00 97.72 O \\\\nATOM 995 CG1 VAL A 122 -14.932 13.260 18.234 1.00 97.72 C \\\\nATOM 996 CG2 VAL A 122 -16.642 13.217 20.035 1.00 97.72 C \\\\nATOM 997 N ASN A 123 -19.565 11.613 17.879 1.00 97.71 N \\\\nATOM 998 CA ASN A 123 -20.654 10.650 18.046 1.00 97.71 C \\\\nATOM 999 C ASN A 123 -20.443 9.497 17.044 1.00 97.71 C \\\\nATOM 1000 CB ASN A 123 -22.010 11.357 17.833 1.00 97.71 C \\\\nATOM 1001 O ASN A 123 -20.509 9.739 15.837 1.00 97.71 O \\\\nATOM 1002 CG ASN A 123 -23.206 10.461 18.123 1.00 97.71 C \\\\nATOM 1003 ND2 ASN A 123 -24.356 11.036 18.386 1.00 97.71 N \\\\nATOM 1004 OD1 ASN A 123 -23.101 9.241 18.132 1.00 97.71 O \\\\nATOM 1005 N PRO A 124 -20.192 8.251 17.485 1.00 97.24 N \\\\nATOM 1006 CA PRO A 124 -19.894 7.164 16.560 1.00 97.24 C \\\\nATOM 1007 C PRO A 124 -21.113 6.735 15.729 1.00 97.24 C \\\\nATOM 1008 CB PRO A 124 -19.341 6.042 17.439 1.00 97.24 C \\\\nATOM 1009 O PRO A 124 -20.937 6.063 14.717 1.00 97.24 O \\\\nATOM 1010 CG PRO A 124 -20.066 6.254 18.763 1.00 97.24 C \\\\nATOM 1011 CD PRO A 124 -20.149 7.776 18.862 1.00 97.24 C \\\\nATOM 1012 N TYR A 125 -22.334 7.132 16.107 1.00 97.21 N \\\\nATOM 1013 CA TYR A 125 -23.568 6.894 15.342 1.00 97.21 C \\\\nATOM 1014 C TYR A 125 -23.873 8.001 14.322 1.00 97.21 C \\\\nATOM 1015 CB TYR A 125 -24.731 6.614 16.304 1.00 97.21 C \\\\nATOM 1016 O TYR A 125 -24.833 7.895 13.569 1.00 97.21 O \\\\nATOM 1017 CG TYR A 125 -24.449 5.401 17.166 1.00 97.21 C \\\\nATOM 1018 CD1 TYR A 125 -24.625 4.107 16.637 1.00 97.21 C \\\\nATOM 1019 CD2 TYR A 125 -23.912 5.567 18.455 1.00 97.21 C \\\\nATOM 1020 CE1 TYR A 125 -24.241 2.979 17.387 1.00 97.21 C \\\\nATOM 1021 CE2 TYR A 125 -23.528 4.440 19.204 1.00 97.21 C \\\\nATOM 1022 OH TYR A 125 -23.321 2.060 19.402 1.00 97.21 O \\\\nATOM 1023 CZ TYR A 125 -23.690 3.144 18.673 1.00 97.21 C \\\\nATOM 1024 N HIS A 126 -23.027 9.035 14.238 1.00 97.82 N \\\\nATOM 1025 CA HIS A 126 -23.063 10.054 13.176 1.00 97.82 C \\\\nATOM 1026 C HIS A 126 -22.159 9.726 11.984 1.00 97.82 C \\\\nATOM 1027 CB HIS A 126 -22.751 11.426 13.780 1.00 97.82 C \\\\nATOM 1028 O HIS A 126 -21.988 10.547 11.084 1.00 97.82 O \\\\nATOM 1029 CG HIS A 126 -23.879 12.016 14.583 1.00 97.82 C \\\\nATOM 1030 CD2 HIS A 126 -25.075 11.415 14.857 1.00 97.82 C \\\\nATOM 1031 ND1 HIS A 126 -23.925 13.346 15.007 1.00 97.82 N \\\\nATOM 1032 CE1 HIS A 126 -25.172 13.518 15.476 1.00 97.82 C \\\\nATOM 1033 NE2 HIS A 126 -25.864 12.375 15.425 1.00 97.82 N \\\\nATOM 1034 N TYR A 127 -21.611 8.513 11.960 1.00 97.31 N \\\\nATOM 1035 CA TYR A 127 -20.844 7.963 10.852 1.00 97.31 C \\\\nATOM 1036 C TYR A 127 -21.405 6.582 10.486 1.00 97.31 C \\\\nATOM 1037 CB TYR A 127 -19.353 7.915 11.234 1.00 97.31 C \\\\nATOM 1038 O TYR A 127 -21.826 5.831 11.364 1.00 97.31 O \\\\nATOM 1039 CG TYR A 127 -18.749 9.275 11.566 1.00 97.31 C \\\\nATOM 1040 CD1 TYR A 127 -18.178 10.061 10.546 1.00 97.31 C \\\\nATOM 1041 CD2 TYR A 127 -18.801 9.777 12.883 1.00 97.31 C \\\\nATOM 1042 CE1 TYR A 127 -17.676 11.346 10.836 1.00 97.31 C \\\\nATOM 1043 CE2 TYR A 127 -18.315 11.068 13.176 1.00 97.31 C \\\\nATOM 1044 OH TYR A 127 -17.256 13.099 12.420 1.00 97.31 O \\\\nATOM 1045 CZ TYR A 127 -17.754 11.859 12.148 1.00 97.31 C \\\\nATOM 1046 N GLN A 128 -21.398 6.218 9.210 1.00 94.94 N \\\\nATOM 1047 CA GLN A 128 -21.660 4.866 8.717 1.00 94.94 C \\\\nATOM 1048 C GLN A 128 -20.363 4.307 8.128 1.00 94.94 C \\\\nATOM 1049 CB GLN A 128 -22.818 4.891 7.707 1.00 94.94 C \\\\nATOM 1050 O GLN A 128 -19.571 5.061 7.559 1.00 94.94 O \\\\nATOM 1051 CG GLN A 128 -23.315 3.479 7.337 1.00 94.94 C \\\\nATOM 1052 CD GLN A 128 -24.500 3.481 6.375 1.00 94.94 C \\\\nATOM 1053 NE2 GLN A 128 -24.954 2.326 5.934 1.00 94.94 N \\\\nATOM 1054 OE1 GLN A 128 -25.037 4.517 6.017 1.00 94.94 O \\\\nATOM 1055 N ARG A 129 -20.128 2.999 8.271 1.00 93.24 N \\\\nATOM 1056 CA ARG A 129 -19.017 2.345 7.577 1.00 93.24 C \\\\nATOM 1057 C ARG A 129 -19.354 2.248 6.093 1.00 93.24 C \\\\nATOM 1058 CB ARG A 129 -18.701 0.979 8.201 1.00 93.24 C \\\\nATOM 1059 O ARG A 129 -20.494 1.964 5.745 1.00 93.24 O \\\\nATOM 1060 CG ARG A 129 -17.357 0.430 7.701 1.00 93.24 C \\\\nATOM 1061 CD ARG A 129 -17.001 -0.874 8.416 1.00 93.24 C \\\\nATOM 1062 NE ARG A 129 -15.580 -1.217 8.225 1.00 93.24 N \\\\nATOM 1063 NH1 ARG A 129 -15.545 -3.069 9.565 1.00 93.24 N \\\\nATOM 1064 NH2 ARG A 129 -13.654 -2.316 8.685 1.00 93.24 N \\\\nATOM 1065 CZ ARG A 129 -14.937 -2.199 8.816 1.00 93.24 C \\\\nATOM 1066 N VAL A 130 -18.379 2.493 5.228 1.00 90.59 N \\\\nATOM 1067 CA VAL A 130 -18.525 2.254 3.792 1.00 90.59 C \\\\nATOM 1068 C VAL A 130 -18.584 0.743 3.573 1.00 90.59 C \\\\nATOM 1069 CB VAL A 130 -17.388 2.919 2.995 1.00 90.59 C \\\\nATOM 1070 O VAL A 130 -17.615 0.034 3.834 1.00 90.59 O \\\\nATOM 1071 CG1 VAL A 130 -17.556 2.671 1.492 1.00 90.59 C \\\\nATOM 1072 CG2 VAL A 130 -17.383 4.441 3.214 1.00 90.59 C \\\\nATOM 1073 N GLU A 131 -19.744 0.256 3.146 1.00 83.73 N \\\\nATOM 1074 CA GLU A 131 -19.983 -1.153 2.835 1.00 83.73 C \\\\nATOM 1075 C GLU A 131 -19.492 -1.473 1.415 1.00 83.73 C \\\\nATOM 1076 CB GLU A 131 -21.480 -1.470 3.027 1.00 83.73 C \\\\nATOM 1077 O GLU A 131 -19.639 -0.659 0.501 1.00 83.73 O \\\\nATOM 1078 CG GLU A 131 -21.875 -1.449 4.519 1.00 83.73 C \\\\nATOM 1079 CD GLU A 131 -23.394 -1.409 4.770 1.00 83.73 C \\\\nATOM 1080 OE1 GLU A 131 -23.785 -0.811 5.806 1.00 83.73 O \\\\nATOM 1081 OE2 GLU A 131 -24.150 -1.953 3.938 1.00 83.73 O \\\\nATOM 1082 N THR A 132 -18.902 -2.655 1.219 1.00 81.31 N \\\\nATOM 1083 CA THR A 132 -18.564 -3.156 -0.121 1.00 81.31 C \\\\nATOM 1084 C THR A 132 -19.844 -3.639 -0.803 1.00 81.31 C \\\\nATOM 1085 CB THR A 132 -17.508 -4.271 -0.069 1.00 81.31 C \\\\nATOM 1086 O THR A 132 -20.510 -4.522 -0.257 1.00 81.31 O \\\\nATOM 1087 CG2 THR A 132 -17.101 -4.782 -1.451 1.00 81.31 C \\\\nATOM 1088 OG1 THR A 132 -16.328 -3.776 0.523 1.00 81.31 O \\\\nATOM 1089 N PRO A 133 -20.218 -3.090 -1.974 1.00 82.14 N \\\\nATOM 1090 CA PRO A 133 -21.417 -3.512 -2.676 1.00 82.14 C \\\\nATOM 1091 C PRO A 133 -21.256 -4.949 -3.177 1.00 82.14 C \\\\nATOM 1092 CB PRO A 133 -21.596 -2.513 -3.821 1.00 82.14 C \\\\nATOM 1093 O PRO A 133 -20.198 -5.332 -3.680 1.00 82.14 O \\\\nATOM 1094 CG PRO A 133 -20.167 -2.064 -4.130 1.00 82.14 C \\\\nATOM 1095 CD PRO A 133 -19.492 -2.105 -2.762 1.00 82.14 C \\\\nATOM 1096 N VAL A 134 -22.324 -5.742 -3.076 1.00 84.73 N \\\\nATOM 1097 CA VAL A 134 -22.350 -7.095 -3.640 1.00 84.73 C \\\\nATOM 1098 C VAL A 134 -22.305 -6.989 -5.163 1.00 84.73 C \\\\nATOM 1099 CB VAL A 134 -23.578 -7.896 -3.166 1.00 84.73 C \\\\nATOM 1100 O VAL A 134 -23.174 -6.370 -5.777 1.00 84.73 O \\\\nATOM 1101 CG1 VAL A 134 -23.554 -9.328 -3.718 1.00 84.73 C \\\\nATOM 1102 CG2 VAL A 134 -23.620 -7.990 -1.634 1.00 84.73 C \\\\nATOM 1103 N LEU A 135 -21.278 -7.581 -5.769 1.00 89.09 N \\\\nATOM 1104 CA LEU A 135 -21.108 -7.609 -7.219 1.00 89.09 C \\\\nATOM 1105 C LEU A 135 -21.987 -8.724 -7.819 1.00 89.09 C \\\\nATOM 1106 CB LEU A 135 -19.617 -7.789 -7.561 1.00 89.09 C \\\\nATOM 1107 O LEU A 135 -21.986 -9.837 -7.283 1.00 89.09 O \\\\nATOM 1108 CG LEU A 135 -18.693 -6.691 -6.997 1.00 89.09 C \\\\nATOM 1109 CD1 LEU A 135 -17.229 -7.061 -7.208 1.00 89.09 C \\\\nATOM 1110 CD2 LEU A 135 -18.944 -5.332 -7.652 1.00 89.09 C \\\\nATOM 1111 N PRO A 136 -22.738 -8.465 -8.907 1.00 88.64 N \\\\nATOM 1112 CA PRO A 136 -23.542 -9.495 -9.559 1.00 88.64 C \\\\nATOM 1113 C PRO A 136 -22.634 -10.566 -10.189 1.00 88.64 C \\\\nATOM 1114 CB PRO A 136 -24.372 -8.757 -10.614 1.00 88.64 C \\\\nATOM 1115 O PRO A 136 -21.542 -10.229 -10.650 1.00 88.64 O \\\\nATOM 1116 CG PRO A 136 -23.484 -7.567 -10.984 1.00 88.64 C \\\\nATOM 1117 CD PRO A 136 -22.802 -7.219 -9.660 1.00 88.64 C \\\\nATOM 1118 N PRO A 137 -23.050 -11.845 -10.241 1.00 90.23 N \\\\nATOM 1119 CA PRO A 137 -22.293 -12.873 -10.945 1.00 90.23 C \\\\nATOM 1120 C PRO A 137 -22.248 -12.582 -12.449 1.00 90.23 C \\\\nATOM 1121 CB PRO A 137 -23.010 -14.193 -10.650 1.00 90.23 C \\\\nATOM 1122 O PRO A 137 -23.247 -12.178 -13.044 1.00 90.23 O \\\\nATOM 1123 CG PRO A 137 -24.458 -13.757 -10.418 1.00 90.23 C \\\\nATOM 1124 CD PRO A 137 -24.311 -12.385 -9.756 1.00 90.23 C \\\\nATOM 1125 N VAL A 138 -21.102 -12.848 -13.072 1.00 90.43 N \\\\nATOM 1126 CA VAL A 138 -20.956 -12.812 -14.533 1.00 90.43 C \\\\nATOM 1127 C VAL A 138 -21.520 -14.113 -15.097 1.00 90.43 C \\\\nATOM 1128 CB VAL A 138 -19.483 -12.596 -14.923 1.00 90.43 C \\\\nATOM 1129 O VAL A 138 -21.149 -15.188 -14.634 1.00 90.43 O \\\\nATOM 1130 CG1 VAL A 138 -19.244 -12.761 -16.426 1.00 90.43 C \\\\nATOM 1131 CG2 VAL A 138 -19.033 -11.184 -14.531 1.00 90.43 C \\\\nATOM 1132 N LEU A 139 -22.432 -14.030 -16.064 1.00 90.13 N \\\\nATOM 1133 CA LEU A 139 -23.028 -15.201 -16.710 1.00 90.13 C \\\\nATOM 1134 C LEU A 139 -22.212 -15.571 -17.950 1.00 90.13 C \\\\nATOM 1135 CB LEU A 139 -24.497 -14.911 -17.070 1.00 90.13 C \\\\nATOM 1136 O LEU A 139 -22.111 -14.764 -18.870 1.00 90.13 O \\\\nATOM 1137 CG LEU A 139 -25.419 -14.571 -15.886 1.00 90.13 C \\\\nATOM 1138 CD1 LEU A 139 -26.852 -14.393 -16.388 1.00 90.13 C \\\\nATOM 1139 CD2 LEU A 139 -25.424 -15.658 -14.809 1.00 90.13 C \\\\nATOM 1140 N VAL A 140 -21.646 -16.777 -17.976 1.00 86.83 N \\\\nATOM 1141 CA VAL A 140 -20.816 -17.263 -19.086 1.00 86.83 C \\\\nATOM 1142 C VAL A 140 -21.594 -18.289 -19.916 1.00 86.83 C \\\\nATOM 1143 CB VAL A 140 -19.483 -17.841 -18.578 1.00 86.83 C \\\\nATOM 1144 O VAL A 140 -22.031 -19.297 -19.353 1.00 86.83 O \\\\nATOM 1145 CG1 VAL A 140 -18.603 -18.256 -19.760 1.00 86.83 C \\\\nATOM 1146 CG2 VAL A 140 -18.706 -16.789 -17.774 1.00 86.83 C \\\\nATOM 1147 N PRO A 141 -21.784 -18.080 -21.233 1.00 80.27 N \\\\nATOM 1148 CA PRO A 141 -22.358 -19.094 -22.111 1.00 80.27 C \\\\nATOM 1149 C PRO A 141 -21.443 -20.313 -22.197 1.00 80.27 C \\\\nATOM 1150 CB PRO A 141 -22.534 -18.428 -23.485 1.00 80.27 C \\\\nATOM 1151 O PRO A 141 -20.263 -20.186 -22.524 1.00 80.27 O \\\\nATOM 1152 CG PRO A 141 -22.470 -16.930 -23.190 1.00 80.27 C \\\\nATOM 1153 CD PRO A 141 -21.543 -16.855 -21.981 1.00 80.27 C \\\\nATOM 1154 N ARG A 142 -21.981 -21.514 -21.970 1.00 69.52 N \\\\nATOM 1155 CA ARG A 142 -21.269 -22.736 -22.351 1.00 69.52 C \\\\nATOM 1156 C ARG A 142 -21.185 -22.821 -23.872 1.00 69.52 C \\\\nATOM 1157 CB ARG A 142 -21.953 -23.967 -21.748 1.00 69.52 C \\\\nATOM 1158 O ARG A 142 -22.206 -22.891 -24.551 1.00 69.52 O \\\\nATOM 1159 CG ARG A 142 -21.631 -24.061 -20.254 1.00 69.52 C \\\\nATOM 1160 CD ARG A 142 -22.346 -25.257 -19.638 1.00 69.52 C \\\\nATOM 1161 NE ARG A 142 -21.928 -25.454 -18.243 1.00 69.52 N \\\\nATOM 1162 NH1 ARG A 142 -23.569 -26.951 -17.623 1.00 69.52 N \\\\nATOM 1163 NH2 ARG A 142 -21.996 -26.344 -16.175 1.00 69.52 N \\\\nATOM 1164 CZ ARG A 142 -22.504 -26.251 -17.367 1.00 69.52 C \\\\nATOM 1165 N HIS A 143 -19.965 -22.851 -24.403 1.00 60.13 N \\\\nATOM 1166 CA HIS A 143 -19.725 -23.115 -25.818 1.00 60.13 C \\\\nATOM 1167 C HIS A 143 -20.074 -24.569 -26.163 1.00 60.13 C \\\\nATOM 1168 CB HIS A 143 -18.268 -22.792 -26.187 1.00 60.13 C \\\\nATOM 1169 O HIS A 143 -19.233 -25.460 -26.058 1.00 60.13 O \\\\nATOM 1170 CG HIS A 143 -17.987 -21.319 -26.313 1.00 60.13 C \\\\nATOM 1171 CD2 HIS A 143 -17.154 -20.573 -25.523 1.00 60.13 C \\\\nATOM 1172 ND1 HIS A 143 -18.492 -20.479 -27.280 1.00 60.13 N \\\\nATOM 1173 CE1 HIS A 143 -17.978 -19.255 -27.072 1.00 60.13 C \\\\nATOM 1174 NE2 HIS A 143 -17.155 -19.264 -26.014 1.00 60.13 N \\\\nATOM 1175 N THR A 144 -21.307 -24.802 -26.609 1.00 49.08 N \\\\nATOM 1176 CA THR A 144 -21.659 -25.991 -27.399 1.00 49.08 C \\\\nATOM 1177 C THR A 144 -21.462 -25.753 -28.894 1.00 49.08 C \\\\nATOM 1178 CB THR A 144 -23.084 -26.500 -27.108 1.00 49.08 C \\\\nATOM 1179 O THR A 144 -20.954 -26.644 -29.567 1.00 49.08 O \\\\nATOM 1180 CG2 THR A 144 -23.051 -27.644 -26.096 1.00 49.08 C \\\\nATOM 1181 OG1 THR A 144 -23.908 -25.493 -26.561 1.00 49.08 O \\\\nATOM 1182 N GLU A 145 -21.785 -24.563 -29.417 1.00 43.90 N \\\\nATOM 1183 CA GLU A 145 -21.641 -24.222 -30.844 1.00 43.90 C \\\\nATOM 1184 C GLU A 145 -21.170 -22.762 -31.027 1.00 43.90 C \\\\nATOM 1185 CB GLU A 145 -22.952 -24.520 -31.606 1.00 43.90 C \\\\nATOM 1186 O GLU A 145 -21.480 -21.888 -30.216 1.00 43.90 O \\\\nATOM 1187 CG GLU A 145 -23.310 -26.023 -31.560 1.00 43.90 C \\\\nATOM 1188 CD GLU A 145 -24.548 -26.438 -32.366 1.00 43.90 C \\\\nATOM 1189 OE1 GLU A 145 -24.808 -27.663 -32.400 1.00 43.90 O \\\\nATOM 1190 OE2 GLU A 145 -25.231 -25.551 -32.922 1.00 43.90 O \\\\nATOM 1191 N ILE A 146 -20.371 -22.501 -32.070 1.00 47.79 N \\\\nATOM 1192 CA ILE A 146 -19.771 -21.185 -32.364 1.00 47.79 C \\\\nATOM 1193 C ILE A 146 -20.657 -20.445 -33.383 1.00 47.79 C \\\\nATOM 1194 CB ILE A 146 -18.323 -21.349 -32.905 1.00 47.79 C \\\\nATOM 1195 O ILE A 146 -20.850 -20.977 -34.478 1.00 47.79 O \\\\nATOM 1196 CG1 ILE A 146 -17.401 -22.045 -31.874 1.00 47.79 C \\\\nATOM 1197 CG2 ILE A 146 -17.724 -19.987 -33.308 1.00 47.79 C \\\\nATOM 1198 CD1 ILE A 146 -16.042 -22.481 -32.443 1.00 47.79 C \\\\nATOM 1199 N PRO A 147 -21.147 -19.220 -33.102 1.00 49.95 N \\\\nATOM 1200 CA PRO A 147 -21.773 -18.379 -34.121 1.00 49.95 C \\\\nATOM 1201 C PRO A 147 -20.759 -18.029 -35.219 1.00 49.95 C \\\\nATOM 1202 CB PRO A 147 -22.294 -17.133 -33.392 1.00 49.95 C \\\\nATOM 1203 O PRO A 147 -19.681 -17.514 -34.929 1.00 49.95 O \\\\nATOM 1204 CG PRO A 147 -22.374 -17.575 -31.931 1.00 49.95 C \\\\nATOM 1205 CD PRO A 147 -21.217 -18.565 -31.807 1.00 49.95 C \\\\nATOM 1206 N ALA A 148 -21.093 -18.327 -36.476 1.00 50.53 N \\\\nATOM 1207 CA ALA A 148 -20.153 -18.237 -37.599 1.00 50.53 C \\\\nATOM 1208 C ALA A 148 -19.879 -16.803 -38.099 1.00 50.53 C \\\\nATOM 1209 CB ALA A 148 -20.670 -19.141 -38.724 1.00 50.53 C \\\\nATOM 1210 O ALA A 148 -18.933 -16.601 -38.856 1.00 50.53 O \\\\nATOM 1211 N GLU A 149 -20.677 -15.819 -37.678 1.00 41.11 N \\\\nATOM 1212 CA GLU A 149 -20.536 -14.413 -38.062 1.00 41.11 C \\\\nATOM 1213 C GLU A 149 -20.661 -13.519 -36.822 1.00 41.11 C \\\\nATOM 1214 CB GLU A 149 -21.581 -14.032 -39.128 1.00 41.11 C \\\\nATOM 1215 O GLU A 149 -21.689 -13.507 -36.145 1.00 41.11 O \\\\nATOM 1216 CG GLU A 149 -21.326 -14.731 -40.475 1.00 41.11 C \\\\nATOM 1217 CD GLU A 149 -22.336 -14.338 -41.566 1.00 41.11 C \\\\nATOM 1218 OE1 GLU A 149 -21.917 -14.275 -42.745 1.00 41.11 O \\\\nATOM 1219 OE2 GLU A 149 -23.526 -14.141 -41.230 1.00 41.11 O \\\\nATOM 1220 N PHE A 150 -19.607 -12.752 -36.542 1.00 50.90 N \\\\nATOM 1221 CA PHE A 150 -19.629 -11.622 -35.614 1.00 50.90 C \\\\nATOM 1222 C PHE A 150 -19.395 -10.328 -36.409 1.00 50.90 C \\\\nATOM 1223 CB PHE A 150 -18.581 -11.808 -34.505 1.00 50.90 C \\\\nATOM 1224 O PHE A 150 -18.740 -10.377 -37.456 1.00 50.90 O \\\\nATOM 1225 CG PHE A 150 -18.997 -12.783 -33.417 1.00 50.90 C \\\\nATOM 1226 CD1 PHE A 150 -19.693 -12.318 -32.284 1.00 50.90 C \\\\nATOM 1227 CD2 PHE A 150 -18.701 -14.154 -33.536 1.00 50.90 C \\\\nATOM 1228 CE1 PHE A 150 -20.083 -13.215 -31.273 1.00 50.90 C \\\\nATOM 1229 CE2 PHE A 150 -19.093 -15.053 -32.528 1.00 50.90 C \\\\nATOM 1230 CZ PHE A 150 -19.783 -14.584 -31.395 1.00 50.90 C \\\\nATOM 1231 N PRO A 151 -19.893 -9.167 -35.939 1.00 45.48 N \\\\nATOM 1232 CA PRO A 151 -19.538 -7.879 -36.527 1.00 45.48 C \\\\nATOM 1233 C PRO A 151 -18.012 -7.690 -36.531 1.00 45.48 C \\\\nATOM 1234 CB PRO A 151 -20.222 -6.811 -35.664 1.00 45.48 C \\\\nATOM 1235 O PRO A 151 -17.342 -8.232 -35.645 1.00 45.48 O \\\\nATOM 1236 CG PRO A 151 -21.324 -7.575 -34.931 1.00 45.48 C \\\\nATOM 1237 CD PRO A 151 -20.732 -8.972 -34.769 1.00 45.48 C \\\\nATOM 1238 N PRO A 152 -17.448 -6.916 -37.477 1.00 43.35 N \\\\nATOM 1239 CA PRO A 152 -16.029 -6.596 -37.439 1.00 43.35 C \\\\nATOM 1240 C PRO A 152 -15.691 -5.935 -36.098 1.00 43.35 C \\\\nATOM 1241 CB PRO A 152 -15.767 -5.682 -38.642 1.00 43.35 C \\\\nATOM 1242 O PRO A 152 -16.322 -4.956 -35.703 1.00 43.35 O \\\\nATOM 1243 CG PRO A 152 -17.138 -5.077 -38.950 1.00 43.35 C \\\\nATOM 1244 CD PRO A 152 -18.120 -6.171 -38.530 1.00 43.35 C \\\\nATOM 1245 N LEU A 153 -14.708 -6.500 -35.396 1.00 46.99 N \\\\nATOM 1246 CA LEU A 153 -14.107 -5.858 -34.233 1.00 46.99 C \\\\nATOM 1247 C LEU A 153 -13.436 -4.565 -34.703 1.00 46.99 C \\\\nATOM 1248 CB LEU A 153 -13.072 -6.804 -33.587 1.00 46.99 C \\\\nATOM 1249 O LEU A 153 -12.665 -4.599 -35.664 1.00 46.99 O \\\\nATOM 1250 CG LEU A 153 -13.670 -8.031 -32.874 1.00 46.99 C \\\\nATOM 1251 CD1 LEU A 153 -12.566 -9.043 -32.557 1.00 46.99 C \\\\nATOM 1252 CD2 LEU A 153 -14.346 -7.649 -31.554 1.00 46.99 C \\\\nATOM 1253 N ASP A 154 -13.695 -3.453 -34.013 1.00 44.28 N \\\\nATOM 1254 CA ASP A 154 -12.870 -2.256 -34.164 1.00 44.28 C \\\\nATOM 1255 C ASP A 154 -11.413 -2.634 -33.881 1.00 44.28 C \\\\nATOM 1256 CB ASP A 154 -13.326 -1.135 -33.215 1.00 44.28 C \\\\nATOM 1257 O ASP A 154 -11.113 -3.281 -32.870 1.00 44.28 O \\\\nATOM 1258 CG ASP A 154 -14.562 -0.385 -33.716 1.00 44.28 C \\\\nATOM 1259 OD1 ASP A 154 -14.599 -0.065 -34.926 1.00 44.28 O \\\\nATOM 1260 OD2 ASP A 154 -15.441 -0.101 -32.871 1.00 44.28 O \\\\nATOM 1261 N ASP A 155 -10.504 -2.262 -34.786 1.00 39.25 N \\\\nATOM 1262 CA ASP A 155 -9.109 -2.671 -34.676 1.00 39.25 C \\\\nATOM 1263 C ASP A 155 -8.376 -1.873 -33.589 1.00 39.25 C \\\\nATOM 1264 CB ASP A 155 -8.374 -2.672 -36.023 1.00 39.25 C \\\\nATOM 1265 O ASP A 155 -7.690 -0.873 -33.821 1.00 39.25 O \\\\nATOM 1266 CG ASP A 155 -6.969 -3.266 -35.845 1.00 39.25 C \\\\nATOM 1267 OD1 ASP A 155 -6.731 -3.949 -34.821 1.00 39.25 O \\\\nATOM 1268 OD2 ASP A 155 -6.084 -3.012 -36.687 1.00 39.25 O \\\\nATOM 1269 N TYR A 156 -8.500 -2.367 -32.362 1.00 43.30 N \\\\nATOM 1270 CA TYR A 156 -7.770 -1.886 -31.202 1.00 43.30 C \\\\nATOM 1271 C TYR A 156 -6.262 -2.222 -31.252 1.00 43.30 C \\\\nATOM 1272 CB TYR A 156 -8.485 -2.362 -29.921 1.00 43.30 C \\\\nATOM 1273 O TYR A 156 -5.565 -1.899 -30.285 1.00 43.30 O \\\\nATOM 1274 CG TYR A 156 -9.726 -1.555 -29.566 1.00 43.30 C \\\\nATOM 1275 CD1 TYR A 156 -9.599 -0.300 -28.937 1.00 43.30 C \\\\nATOM 1276 CD2 TYR A 156 -11.012 -2.049 -29.857 1.00 43.30 C \\\\nATOM 1277 CE1 TYR A 156 -10.733 0.470 -28.621 1.00 43.30 C \\\\nATOM 1278 CE2 TYR A 156 -12.154 -1.294 -29.526 1.00 43.30 C \\\\nATOM 1279 OH TYR A 156 -13.120 0.694 -28.593 1.00 43.30 O \\\\nATOM 1280 CZ TYR A 156 -12.018 -0.032 -28.914 1.00 43.30 C \\\\nATOM 1281 N SER A 157 -5.703 -2.776 -32.343 1.00 44.03 N \\\\nATOM 1282 CA SER A 157 -4.243 -2.892 -32.529 1.00 44.03 C \\\\nATOM 1283 C SER A 157 -3.537 -1.535 -32.392 1.00 44.03 C \\\\nATOM 1284 CB SER A 157 -3.889 -3.535 -33.881 1.00 44.03 C \\\\nATOM 1285 O SER A 157 -2.504 -1.435 -31.732 1.00 44.03 O \\\\nATOM 1286 OG SER A 157 -4.039 -2.628 -34.955 1.00 44.03 O \\\\nATOM 1287 N HIS A 158 -4.160 -0.458 -32.880 1.00 38.34 N \\\\nATOM 1288 CA HIS A 158 -3.667 0.916 -32.739 1.00 38.34 C \\\\nATOM 1289 C HIS A 158 -3.891 1.533 -31.347 1.00 38.34 C \\\\nATOM 1290 CB HIS A 158 -4.280 1.774 -33.850 1.00 38.34 C \\\\nATOM 1291 O HIS A 158 -3.365 2.606 -31.059 1.00 38.34 O \\\\nATOM 1292 CG HIS A 158 -3.831 1.351 -35.226 1.00 38.34 C \\\\nATOM 1293 CD2 HIS A 158 -4.630 1.066 -36.301 1.00 38.34 C \\\\nATOM 1294 ND1 HIS A 158 -2.527 1.162 -35.629 1.00 38.34 N \\\\nATOM 1295 CE1 HIS A 158 -2.543 0.778 -36.915 1.00 38.34 C \\\\nATOM 1296 NE2 HIS A 158 -3.798 0.739 -37.379 1.00 38.34 N \\\\nATOM 1297 N SER A 159 -4.625 0.858 -30.456 1.00 38.83 N \\\\nATOM 1298 CA SER A 159 -4.744 1.260 -29.046 1.00 38.83 C \\\\nATOM 1299 C SER A 159 -3.651 0.669 -28.154 1.00 38.83 C \\\\nATOM 1300 CB SER A 159 -6.123 0.917 -28.499 1.00 38.83 C \\\\nATOM 1301 O SER A 159 -3.557 1.043 -26.982 1.00 38.83 O \\\\nATOM 1302 OG SER A 159 -6.218 -0.454 -28.156 1.00 38.83 O \\\\nATOM 1303 N ILE A 160 -2.822 -0.242 -28.689 1.00 40.21 N \\\\nATOM 1304 CA ILE A 160 -1.624 -0.744 -28.015 1.00 40.21 C \\\\nATOM 1305 C ILE A 160 -0.648 0.430 -27.888 1.00 40.21 C \\\\nATOM 1306 CB ILE A 160 -0.969 -1.918 -28.780 1.00 40.21 C \\\\nATOM 1307 O ILE A 160 -0.074 0.861 -28.888 1.00 40.21 O \\\\nATOM 1308 CG1 ILE A 160 -1.959 -3.092 -28.956 1.00 40.21 C \\\\nATOM 1309 CG2 ILE A 160 0.289 -2.393 -28.019 1.00 40.21 C \\\\nATOM 1310 CD1 ILE A 160 -1.440 -4.208 -29.872 1.00 40.21 C \\\\nATOM 1311 N PRO A 161 -0.412 0.962 -26.681 1.00 43.58 N \\\\nATOM 1312 CA PRO A 161 0.552 2.023 -26.524 1.00 43.58 C \\\\nATOM 1313 C PRO A 161 1.932 1.384 -26.370 1.00 43.58 C \\\\nATOM 1314 CB PRO A 161 0.068 2.791 -25.297 1.00 43.58 C \\\\nATOM 1315 O PRO A 161 2.152 0.600 -25.449 1.00 43.58 O \\\\nATOM 1316 CG PRO A 161 -0.750 1.782 -24.475 1.00 43.58 C \\\\nATOM 1317 CD PRO A 161 -0.924 0.562 -25.378 1.00 43.58 C \\\\nATOM 1318 N GLU A 162 2.907 1.787 -27.186 1.00 51.97 N \\\\nATOM 1319 CA GLU A 162 4.313 1.330 -27.096 1.00 51.97 C \\\\nATOM 1320 C GLU A 162 4.959 1.568 -25.708 1.00 51.97 C \\\\nATOM 1321 CB GLU A 162 5.148 2.041 -28.171 1.00 51.97 C \\\\nATOM 1322 O GLU A 162 6.053 1.091 -25.403 1.00 51.97 O \\\\nATOM 1323 CG GLU A 162 4.705 1.733 -29.611 1.00 51.97 C \\\\nATOM 1324 CD GLU A 162 5.627 2.428 -30.624 1.00 51.97 C \\\\nATOM 1325 OE1 GLU A 162 6.049 1.755 -31.589 1.00 51.97 O \\\\nATOM 1326 OE2 GLU A 162 5.927 3.624 -30.395 1.00 51.97 O \\\\nATOM 1327 N ASN A 163 4.263 2.268 -24.805 1.00 55.17 N \\\\nATOM 1328 CA ASN A 163 4.623 2.384 -23.398 1.00 55.17 C \\\\nATOM 1329 C ASN A 163 4.496 1.090 -22.566 1.00 55.17 C \\\\nATOM 1330 CB ASN A 163 3.936 3.622 -22.785 1.00 55.17 C \\\\nATOM 1331 O ASN A 163 4.902 1.119 -21.402 1.00 55.17 O \\\\nATOM 1332 CG ASN A 163 2.443 3.565 -22.528 1.00 55.17 C \\\\nATOM 1333 ND2 ASN A 163 1.793 4.704 -22.602 1.00 55.17 N \\\\nATOM 1334 OD1 ASN A 163 1.852 2.571 -22.154 1.00 55.17 O \\\\nATOM 1335 N THR A 164 4.011 -0.025 -23.135 1.00 50.75 N \\\\nATOM 1336 CA THR A 164 3.756 -1.293 -22.421 1.00 50.75 C \\\\nATOM 1337 C THR A 164 4.792 -2.411 -22.609 1.00 50.75 C \\\\nATOM 1338 CB THR A 164 2.345 -1.846 -22.708 1.00 50.75 C \\\\nATOM 1339 O THR A 164 4.489 -3.547 -22.245 1.00 50.75 O \\\\nATOM 1340 CG2 THR A 164 1.248 -0.843 -22.368 1.00 50.75 C \\\\nATOM 1341 OG1 THR A 164 2.175 -2.204 -24.057 1.00 50.75 O \\\\nATOM 1342 N ASN A 165 5.985 -2.158 -23.162 1.00 46.01 N \\\\nATOM 1343 CA ASN A 165 6.958 -3.231 -23.437 1.00 46.01 C \\\\nATOM 1344 C ASN A 165 7.416 -3.989 -22.172 1.00 46.01 C \\\\nATOM 1345 CB ASN A 165 8.159 -2.701 -24.250 1.00 46.01 C \\\\nATOM 1346 O ASN A 165 8.296 -3.539 -21.434 1.00 46.01 O \\\\nATOM 1347 CG ASN A 165 7.840 -2.535 -25.727 1.00 46.01 C \\\\nATOM 1348 ND2 ASN A 165 8.836 -2.447 -26.576 1.00 46.01 N \\\\nATOM 1349 OD1 ASN A 165 6.696 -2.500 -26.135 1.00 46.01 O \\\\nATOM 1350 N PHE A 166 6.859 -5.189 -21.983 1.00 39.23 N \\\\nATOM 1351 CA PHE A 166 7.439 -6.247 -21.160 1.00 39.23 C \\\\nATOM 1352 C PHE A 166 8.686 -6.815 -21.859 1.00 39.23 C \\\\nATOM 1353 CB PHE A 166 6.422 -7.383 -20.959 1.00 39.23 C \\\\nATOM 1354 O PHE A 166 8.648 -7.028 -23.072 1.00 39.23 O \\\\nATOM 1355 CG PHE A 166 5.298 -7.094 -19.983 1.00 39.23 C \\\\nATOM 1356 CD1 PHE A 166 5.477 -7.366 -18.612 1.00 39.23 C \\\\nATOM 1357 CD2 PHE A 166 4.061 -6.601 -20.440 1.00 39.23 C \\\\nATOM 1358 CE1 PHE A 166 4.427 -7.142 -17.704 1.00 39.23 C \\\\nATOM 1359 CE2 PHE A 166 3.004 -6.398 -19.533 1.00 39.23 C \\\\nATOM 1360 CZ PHE A 166 3.188 -6.666 -18.165 1.00 39.23 C \\\\nATOM 1361 N PRO A 167 9.773 -7.129 -21.133 1.00 38.71 N \\\\nATOM 1362 CA PRO A 167 10.925 -7.804 -21.715 1.00 38.71 C \\\\nATOM 1363 C PRO A 167 10.655 -9.311 -21.872 1.00 38.71 C \\\\nATOM 1364 CB PRO A 167 12.089 -7.465 -20.778 1.00 38.71 C \\\\nATOM 1365 O PRO A 167 11.086 -10.120 -21.052 1.00 38.71 O \\\\nATOM 1366 CG PRO A 167 11.413 -7.359 -19.411 1.00 38.71 C \\\\nATOM 1367 CD PRO A 167 10.026 -6.799 -19.738 1.00 38.71 C \\\\nATOM 1368 N ALA A 168 9.985 -9.694 -22.961 1.00 35.78 N \\\\nATOM 1369 CA ALA A 168 10.348 -10.935 -23.644 1.00 35.78 C \\\\nATOM 1370 C ALA A 168 11.684 -10.665 -24.361 1.00 35.78 C \\\\nATOM 1371 CB ALA A 168 9.221 -11.358 -24.591 1.00 35.78 C \\\\nATOM 1372 O ALA A 168 11.835 -9.631 -25.011 1.00 35.78 O \\\\nATOM 1373 N GLY A 169 12.697 -11.498 -24.123 1.00 29.87 N \\\\nATOM 1374 CA GLY A 169 14.087 -11.107 -24.379 1.00 29.87 C \\\\nATOM 1375 C GLY A 169 14.470 -11.009 -25.859 1.00 29.87 C \\\\nATOM 1376 O GLY A 169 14.032 -11.835 -26.648 1.00 29.87 O \\\\nATOM 1377 N ILE A 170 15.332 -10.035 -26.181 1.00 36.65 N \\\\nATOM 1378 CA ILE A 170 16.510 -10.086 -27.078 1.00 36.65 C \\\\nATOM 1379 C ILE A 170 17.256 -8.728 -26.959 1.00 36.65 C \\\\nATOM 1380 CB ILE A 170 16.148 -10.534 -28.525 1.00 36.65 C \\\\nATOM 1381 O ILE A 170 16.703 -7.734 -26.495 1.00 36.65 O \\\\nATOM 1382 CG1 ILE A 170 16.237 -12.082 -28.648 1.00 36.65 C \\\\nATOM 1383 CG2 ILE A 170 17.054 -9.959 -29.631 1.00 36.65 C \\\\nATOM 1384 CD1 ILE A 170 15.229 -12.665 -29.647 1.00 36.65 C \\\\nATOM 1385 N GLU A 171 18.553 -8.749 -27.253 1.00 33.34 N \\\\nATOM 1386 CA GLU A 171 19.647 -7.827 -26.886 1.00 33.34 C \\\\nATOM 1387 C GLU A 171 19.508 -6.322 -27.262 1.00 33.34 C \\\\nATOM 1388 CB GLU A 171 20.912 -8.384 -27.563 1.00 33.34 C \\\\nATOM 1389 O GLU A 171 18.815 -5.979 -28.219 1.00 33.34 O \\\\nATOM 1390 CG GLU A 171 21.205 -9.850 -27.182 1.00 33.34 C \\\\nATOM 1391 CD GLU A 171 22.413 -10.424 -27.929 1.00 33.34 C \\\\nATOM 1392 OE1 GLU A 171 23.174 -11.173 -27.278 1.00 33.34 O \\\\nATOM 1393 OE2 GLU A 171 22.553 -10.127 -29.136 1.00 33.34 O \\\\nATOM 1394 N PRO A 172 20.211 -5.394 -26.564 1.00 32.49 N \\\\nATOM 1395 CA PRO A 172 20.148 -3.952 -26.836 1.00 32.49 C \\\\nATOM 1396 C PRO A 172 21.300 -3.415 -27.713 1.00 32.49 C \\\\nATOM 1397 CB PRO A 172 20.199 -3.318 -25.443 1.00 32.49 C \\\\nATOM 1398 O PRO A 172 22.469 -3.712 -27.466 1.00 32.49 O \\\\nATOM 1399 CG PRO A 172 21.162 -4.236 -24.683 1.00 32.49 C \\\\nATOM 1400 CD PRO A 172 20.926 -5.616 -25.309 1.00 32.49 C \\\\nATOM 1401 N GLN A 173 21.001 -2.487 -28.635 1.00 36.11 N \\\\nATOM 1402 CA GLN A 173 22.011 -1.656 -29.317 1.00 36.11 C \\\\nATOM 1403 C GLN A 173 21.726 -0.141 -29.211 1.00 36.11 C \\\\nATOM 1404 CB GLN A 173 22.234 -2.115 -30.772 1.00 36.11 C \\\\nATOM 1405 O GLN A 173 20.910 0.426 -29.924 1.00 36.11 O \\\\nATOM 1406 CG GLN A 173 23.064 -3.412 -30.836 1.00 36.11 C \\\\nATOM 1407 CD GLN A 173 23.549 -3.774 -32.240 1.00 36.11 C \\\\nATOM 1408 NE2 GLN A 173 24.380 -4.785 -32.370 1.00 36.11 N \\\\nATOM 1409 OE1 GLN A 173 23.215 -3.168 -33.243 1.00 36.11 O \\\\nATOM 1410 N SER A 174 22.463 0.497 -28.294 1.00 35.78 N \\\\nATOM 1411 CA SER A 174 23.201 1.768 -28.464 1.00 35.78 C \\\\nATOM 1412 C SER A 174 22.584 3.014 -29.161 1.00 35.78 C \\\\nATOM 1413 CB SER A 174 24.544 1.424 -29.129 1.00 35.78 C \\\\nATOM 1414 O SER A 174 22.504 3.069 -30.383 1.00 35.78 O \\\\nATOM 1415 OG SER A 174 24.359 0.851 -30.404 1.00 35.78 O \\\\nATOM 1416 N ASN A 175 22.484 4.104 -28.369 1.00 35.08 N \\\\nATOM 1417 CA ASN A 175 23.258 5.374 -28.501 1.00 35.08 C \\\\nATOM 1418 C ASN A 175 22.610 6.746 -28.897 1.00 35.08 C \\\\nATOM 1419 CB ASN A 175 24.603 5.154 -29.250 1.00 35.08 C \\\\nATOM 1420 O ASN A 175 22.404 7.013 -30.071 1.00 35.08 O \\\\nATOM 1421 CG ASN A 175 25.726 4.615 -28.377 1.00 35.08 C \\\\nATOM 1422 ND2 ASN A 175 26.864 4.315 -28.954 1.00 35.08 N \\\\nATOM 1423 OD1 ASN A 175 25.602 4.449 -27.175 1.00 35.08 O \\\\nATOM 1424 N ILE A 176 22.622 7.684 -27.909 1.00 42.21 N \\\\nATOM 1425 CA ILE A 176 23.071 9.121 -27.980 1.00 42.21 C \\\\nATOM 1426 C ILE A 176 22.116 10.155 -28.683 1.00 42.21 C \\\\nATOM 1427 CB ILE A 176 24.533 9.124 -28.560 1.00 42.21 C \\\\nATOM 1428 O ILE A 176 21.554 9.825 -29.717 1.00 42.21 O \\\\nATOM 1429 CG1 ILE A 176 25.528 8.202 -27.803 1.00 42.21 C \\\\nATOM 1430 CG2 ILE A 176 25.248 10.481 -28.601 1.00 42.21 C \\\\nATOM 1431 CD1 ILE A 176 26.821 7.896 -28.587 1.00 42.21 C \\\\nATOM 1432 N PRO A 177 21.984 11.451 -28.260 1.00 34.10 N \\\\nATOM 1433 CA PRO A 177 21.878 12.076 -26.925 1.00 34.10 C \\\\nATOM 1434 C PRO A 177 20.748 13.164 -26.840 1.00 34.10 C \\\\nATOM 1435 CB PRO A 177 23.238 12.758 -26.772 1.00 34.10 C \\\\nATOM 1436 O PRO A 177 19.832 13.216 -27.651 1.00 34.10 O \\\\nATOM 1437 CG PRO A 177 23.430 13.356 -28.173 1.00 34.10 C \\\\nATOM 1438 CD PRO A 177 22.508 12.528 -29.094 1.00 34.10 C \\\\nATOM 1439 N GLU A 178 20.803 14.056 -25.840 1.00 31.22 N \\\\nATOM 1440 CA GLU A 178 19.766 15.049 -25.493 1.00 31.22 C \\\\nATOM 1441 C GLU A 178 19.873 16.441 -26.160 1.00 31.22 C \\\\nATOM 1442 CB GLU A 178 19.800 15.310 -23.972 1.00 31.22 C \\\\nATOM 1443 O GLU A 178 20.954 17.024 -26.197 1.00 31.22 O \\\\nATOM 1444 CG GLU A 178 19.939 14.061 -23.097 1.00 31.22 C \\\\nATOM 1445 CD GLU A 178 19.667 14.394 -21.630 1.00 31.22 C \\\\nATOM 1446 OE1 GLU A 178 18.475 14.276 -21.249 1.00 31.22 O \\\\nATOM 1447 OE2 GLU A 178 20.612 14.760 -20.908 1.00 31.22 O \\\\nATOM 1448 N THR A 179 18.718 17.054 -26.467 1.00 36.45 N \\\\nATOM 1449 CA THR A 179 18.493 18.520 -26.512 1.00 36.45 C \\\\nATOM 1450 C THR A 179 17.057 18.880 -26.052 1.00 36.45 C \\\\nATOM 1451 CB THR A 179 18.724 19.135 -27.909 1.00 36.45 C \\\\nATOM 1452 O THR A 179 16.109 18.175 -26.403 1.00 36.45 O \\\\nATOM 1453 CG2 THR A 179 20.193 19.431 -28.204 1.00 36.45 C \\\\nATOM 1454 OG1 THR A 179 18.255 18.284 -28.926 1.00 36.45 O \\\\nATOM 1455 N PRO A 180 16.865 19.933 -25.227 1.00 38.72 N \\\\nATOM 1456 CA PRO A 180 15.547 20.523 -24.897 1.00 38.72 C \\\\nATOM 1457 C PRO A 180 15.526 22.074 -25.039 1.00 38.72 C \\\\nATOM 1458 CB PRO A 180 15.411 20.132 -23.420 1.00 38.72 C \\\\nATOM 1459 O PRO A 180 16.585 22.664 -25.249 1.00 38.72 O \\\\nATOM 1460 CG PRO A 180 16.821 20.396 -22.876 1.00 38.72 C \\\\nATOM 1461 CD PRO A 180 17.742 20.136 -24.075 1.00 38.72 C \\\\nATOM 1462 N PRO A 181 14.425 22.785 -24.695 1.00 44.75 N \\\\nATOM 1463 CA PRO A 181 12.998 22.573 -24.970 1.00 44.75 C \\\\nATOM 1464 C PRO A 181 12.578 23.642 -26.037 1.00 44.75 C \\\\nATOM 1465 CB PRO A 181 12.406 22.621 -23.564 1.00 44.75 C \\\\nATOM 1466 O PRO A 181 13.211 23.555 -27.088 1.00 44.75 O \\\\nATOM 1467 CG PRO A 181 13.195 23.757 -22.893 1.00 44.75 C \\\\nATOM 1468 CD PRO A 181 14.509 23.832 -23.686 1.00 44.75 C \\\\nATOM 1469 N PRO A 182 11.679 24.667 -25.892 1.00 38.69 N \\\\nATOM 1470 CA PRO A 182 10.580 25.008 -24.958 1.00 38.69 C \\\\nATOM 1471 C PRO A 182 9.177 24.739 -25.580 1.00 38.69 C \\\\nATOM 1472 CB PRO A 182 10.839 26.493 -24.650 1.00 38.69 C \\\\nATOM 1473 O PRO A 182 9.040 23.844 -26.406 1.00 38.69 O \\\\nATOM 1474 CG PRO A 182 11.386 27.063 -25.956 1.00 38.69 C \\\\nATOM 1475 CD PRO A 182 11.791 25.833 -26.773 1.00 38.69 C \\\\nATOM 1476 N GLY A 183 8.136 25.483 -25.169 1.00 30.01 N \\\\nATOM 1477 CA GLY A 183 6.812 25.582 -25.824 1.00 30.01 C \\\\nATOM 1478 C GLY A 183 6.240 27.004 -25.675 1.00 30.01 C \\\\nATOM 1479 O GLY A 183 6.944 27.820 -25.092 1.00 30.01 O \\\\nATOM 1480 N TYR A 184 5.022 27.310 -26.155 1.00 39.51 N \\\\nATOM 1481 CA TYR A 184 4.191 28.473 -25.752 1.00 39.51 C \\\\nATOM 1482 C TYR A 184 2.738 28.354 -26.304 1.00 39.51 C \\\\nATOM 1483 CB TYR A 184 4.832 29.829 -26.159 1.00 39.51 C \\\\nATOM 1484 O TYR A 184 2.514 27.690 -27.308 1.00 39.51 O \\\\nATOM 1485 CG TYR A 184 5.058 30.825 -25.014 1.00 39.51 C \\\\nATOM 1486 CD1 TYR A 184 4.208 31.938 -24.856 1.00 39.51 C \\\\nATOM 1487 CD2 TYR A 184 6.147 30.684 -24.126 1.00 39.51 C \\\\nATOM 1488 CE1 TYR A 184 4.418 32.858 -23.805 1.00 39.51 C \\\\nATOM 1489 CE2 TYR A 184 6.360 31.588 -23.072 1.00 39.51 C \\\\nATOM 1490 OH TYR A 184 5.701 33.561 -21.892 1.00 39.51 O \\\\nATOM 1491 CZ TYR A 184 5.489 32.680 -22.905 1.00 39.51 C \\\\nATOM 1492 N LEU A 185 1.807 28.987 -25.580 1.00 35.19 N \\\\nATOM 1493 CA LEU A 185 0.381 29.350 -25.789 1.00 35.19 C \\\\nATOM 1494 C LEU A 185 -0.415 29.022 -27.091 1.00 35.19 C \\\\nATOM 1495 CB LEU A 185 0.305 30.876 -25.571 1.00 35.19 C \\\\nATOM 1496 O LEU A 185 -0.010 29.385 -28.186 1.00 35.19 O \\\\nATOM 1497 CG LEU A 185 0.771 31.371 -24.187 1.00 35.19 C \\\\nATOM 1498 CD1 LEU A 185 0.821 32.896 -24.155 1.00 35.19 C \\\\nATOM 1499 CD2 LEU A 185 -0.152 30.898 -23.064 1.00 35.19 C \\\\nATOM 1500 N SER A 186 -1.622 28.473 -26.858 1.00 34.39 N \\\\nATOM 1501 CA SER A 186 -2.988 28.878 -27.296 1.00 34.39 C \\\\nATOM 1502 C SER A 186 -3.303 29.479 -28.681 1.00 34.39 C \\\\nATOM 1503 CB SER A 186 -3.534 29.907 -26.294 1.00 34.39 C \\\\nATOM 1504 O SER A 186 -2.736 30.504 -29.031 1.00 34.39 O \\\\nATOM 1505 OG SER A 186 -3.317 29.516 -24.945 1.00 34.39 O \\\\nATOM 1506 N GLU A 187 -4.399 29.001 -29.302 1.00 39.49 N \\\\nATOM 1507 CA GLU A 187 -5.525 29.837 -29.798 1.00 39.49 C \\\\nATOM 1508 C GLU A 187 -6.809 29.001 -30.054 1.00 39.49 C \\\\nATOM 1509 CB GLU A 187 -5.139 30.702 -31.023 1.00 39.49 C \\\\nATOM 1510 O GLU A 187 -6.735 27.781 -30.217 1.00 39.49 O \\\\nATOM 1511 CG GLU A 187 -5.129 32.188 -30.606 1.00 39.49 C \\\\nATOM 1512 CD GLU A 187 -4.650 33.164 -31.695 1.00 39.49 C \\\\nATOM 1513 OE1 GLU A 187 -5.250 34.262 -31.783 1.00 39.49 O \\\\nATOM 1514 OE2 GLU A 187 -3.662 32.854 -32.400 1.00 39.49 O \\\\nATOM 1515 N ASP A 188 -7.981 29.651 -30.011 1.00 34.92 N \\\\nATOM 1516 CA ASP A 188 -9.330 29.047 -29.984 1.00 34.92 C \\\\nATOM 1517 C ASP A 188 -9.981 28.853 -31.376 1.00 34.92 C \\\\nATOM 1518 CB ASP A 188 -10.245 29.934 -29.116 1.00 34.92 C \\\\nATOM 1519 O ASP A 188 -9.538 29.415 -32.378 1.00 34.92 O \\\\nATOM 1520 CG ASP A 188 -9.788 30.022 -27.658 1.00 34.92 C \\\\nATOM 1521 OD1 ASP A 188 -9.987 29.023 -26.931 1.00 34.92 O \\\\nATOM 1522 OD2 ASP A 188 -9.236 31.080 -27.276 1.00 34.92 O \\\\nATOM 1523 N GLY A 189 -11.098 28.109 -31.437 1.00 37.79 N \\\\nATOM 1524 CA GLY A 189 -11.931 27.992 -32.644 1.00 37.79 C \\\\nATOM 1525 C GLY A 189 -13.313 27.363 -32.408 1.00 37.79 C \\\\nATOM 1526 O GLY A 189 -13.435 26.143 -32.331 1.00 37.79 O \\\\nATOM 1527 N GLU A 190 -14.361 28.192 -32.341 1.00 33.29 N \\\\nATOM 1528 CA GLU A 190 -15.779 27.783 -32.283 1.00 33.29 C \\\\nATOM 1529 C GLU A 190 -16.458 27.848 -33.669 1.00 33.29 C \\\\nATOM 1530 CB GLU A 190 -16.569 28.709 -31.334 1.00 33.29 C \\\\nATOM 1531 O GLU A 190 -16.091 28.687 -34.487 1.00 33.29 O \\\\nATOM 1532 CG GLU A 190 -16.107 28.723 -29.870 1.00 33.29 C \\\\nATOM 1533 CD GLU A 190 -17.007 29.639 -29.018 1.00 33.29 C \\\\nATOM 1534 OE1 GLU A 190 -17.574 29.139 -28.019 1.00 33.29 O \\\\nATOM 1535 OE2 GLU A 190 -17.140 30.831 -29.380 1.00 33.29 O \\\\nATOM 1536 N THR A 191 -17.458 26.990 -33.929 1.00 42.71 N \\\\nATOM 1537 CA THR A 191 -18.598 27.103 -34.895 1.00 42.71 C \\\\nATOM 1538 C THR A 191 -19.276 25.716 -35.016 1.00 42.71 C \\\\nATOM 1539 CB THR A 191 -18.207 27.533 -36.336 1.00 42.71 C \\\\nATOM 1540 O THR A 191 -18.584 24.710 -34.902 1.00 42.71 O \\\\nATOM 1541 CG2 THR A 191 -18.196 29.048 -36.589 1.00 42.71 C \\\\nATOM 1542 OG1 THR A 191 -16.938 27.058 -36.710 1.00 42.71 O \\\\nATOM 1543 N SER A 192 -20.579 25.502 -35.263 1.00 40.70 N \\\\nATOM 1544 CA SER A 192 -21.818 26.304 -35.160 1.00 40.70 C \\\\nATOM 1545 C SER A 192 -23.040 25.348 -35.172 1.00 40.70 C \\\\nATOM 1546 CB SER A 192 -21.980 27.261 -36.348 1.00 40.70 C \\\\nATOM 1547 O SER A 192 -22.941 24.232 -35.679 1.00 40.70 O \\\\nATOM 1548 OG SER A 192 -21.283 28.465 -36.112 1.00 40.70 O \\\\nATOM 1549 N ASP A 193 -24.191 25.782 -34.643 1.00 32.70 N \\\\nATOM 1550 CA ASP A 193 -25.446 25.002 -34.558 1.00 32.70 C \\\\nATOM 1551 C ASP A 193 -26.161 24.721 -35.895 1.00 32.70 C \\\\nATOM 1552 CB ASP A 193 -26.463 25.781 -33.704 1.00 32.70 C \\\\nATOM 1553 O ASP A 193 -26.122 25.534 -36.818 1.00 32.70 O \\\\nATOM 1554 CG ASP A 193 -26.155 25.743 -32.216 1.00 32.70 C \\\\nATOM 1555 OD1 ASP A 193 -26.245 24.629 -31.656 1.00 32.70 O \\\\nATOM 1556 OD2 ASP A 193 -25.885 26.830 -31.664 1.00 32.70 O \\\\nATOM 1557 N HIS A 194 -26.991 23.664 -35.917 1.00 43.62 N \\\\nATOM 1558 CA HIS A 194 -28.169 23.580 -36.797 1.00 43.62 C \\\\nATOM 1559 C HIS A 194 -29.393 22.927 -36.111 1.00 43.62 C \\\\nATOM 1560 CB HIS A 194 -27.822 22.876 -38.123 1.00 43.62 C \\\\nATOM 1561 O HIS A 194 -29.395 21.740 -35.792 1.00 43.62 O \\\\nATOM 1562 CG HIS A 194 -27.307 23.818 -39.187 1.00 43.62 C \\\\nATOM 1563 CD2 HIS A 194 -26.093 23.766 -39.821 1.00 43.62 C \\\\nATOM 1564 ND1 HIS A 194 -27.980 24.906 -39.701 1.00 43.62 N \\\\nATOM 1565 CE1 HIS A 194 -27.186 25.497 -40.608 1.00 43.62 C \\\\nATOM 1566 NE2 HIS A 194 -26.036 24.823 -40.740 1.00 43.62 N \\\\nATOM 1567 N GLN A 195 -30.471 23.707 -35.955 1.00 34.38 N \\\\nATOM 1568 CA GLN A 195 -31.841 23.260 -35.637 1.00 34.38 C \\\\nATOM 1569 C GLN A 195 -32.716 23.226 -36.901 1.00 34.38 C \\\\nATOM 1570 CB GLN A 195 -32.523 24.269 -34.690 1.00 34.38 C \\\\nATOM 1571 O GLN A 195 -32.548 24.103 -37.742 1.00 34.38 O \\\\nATOM 1572 CG GLN A 195 -32.220 24.116 -33.198 1.00 34.38 C \\\\nATOM 1573 CD GLN A 195 -32.992 25.136 -32.354 1.00 34.38 C \\\\nATOM 1574 NE2 GLN A 195 -32.890 25.070 -31.046 1.00 34.38 N \\\\nATOM 1575 OE1 GLN A 195 -33.706 26.001 -32.834 1.00 34.38 O \\\\nATOM 1576 N MET A 196 -33.689 22.298 -36.971 1.00 43.58 N \\\\nATOM 1577 CA MET A 196 -34.997 22.344 -37.686 1.00 43.58 C \\\\nATOM 1578 C MET A 196 -35.638 20.930 -37.660 1.00 43.58 C \\\\nATOM 1579 CB MET A 196 -34.835 22.770 -39.167 1.00 43.58 C \\\\nATOM 1580 O MET A 196 -34.898 19.954 -37.655 1.00 43.58 O \\\\nATOM 1581 CG MET A 196 -34.842 24.298 -39.367 1.00 43.58 C \\\\nATOM 1582 SD MET A 196 -36.152 24.997 -40.407 1.00 43.58 S \\\\nATOM 1583 CE MET A 196 -35.694 26.747 -40.262 1.00 43.58 C \\\\nATOM 1584 N ASN A 197 -36.958 20.690 -37.705 1.00 41.11 N \\\\nATOM 1585 CA ASN A 197 -38.153 21.466 -37.322 1.00 41.11 C \\\\nATOM 1586 C ASN A 197 -39.364 20.485 -37.186 1.00 41.11 C \\\\nATOM 1587 CB ASN A 197 -38.439 22.571 -38.361 1.00 41.11 C \\\\nATOM 1588 O ASN A 197 -39.254 19.313 -37.540 1.00 41.11 O \\\\nATOM 1589 CG ASN A 197 -39.298 23.710 -37.834 1.00 41.11 C \\\\nATOM 1590 ND2 ASN A 197 -39.465 24.753 -38.609 1.00 41.11 N \\\\nATOM 1591 OD1 ASN A 197 -39.813 23.690 -36.728 1.00 41.11 O \\\\nATOM 1592 N HIS A 198 -40.511 20.944 -36.673 1.00 40.12 N \\\\nATOM 1593 CA HIS A 198 -41.731 20.157 -36.393 1.00 40.12 C \\\\nATOM 1594 C HIS A 198 -42.478 19.583 -37.619 1.00 40.12 C \\\\nATOM 1595 CB HIS A 198 -42.733 21.089 -35.691 1.00 40.12 C \\\\nATOM 1596 O HIS A 198 -42.436 20.176 -38.696 1.00 40.12 O \\\\nATOM 1597 CG HIS A 198 -42.362 21.505 -34.298 1.00 40.12 C \\\\nATOM 1598 CD2 HIS A 198 -41.690 22.640 -33.929 1.00 40.12 C \\\\nATOM 1599 ND1 HIS A 198 -42.742 20.860 -33.143 1.00 40.12 N \\\\nATOM 1600 CE1 HIS A 198 -42.304 21.586 -32.102 1.00 40.12 C \\\\nATOM 1601 NE2 HIS A 198 -41.659 22.679 -32.531 1.00 40.12 N \\\\nATOM 1602 N SER A 199 -43.319 18.552 -37.397 1.00 44.95 N \\\\nATOM 1603 CA SER A 199 -44.767 18.530 -37.752 1.00 44.95 C \\\\nATOM 1604 C SER A 199 -45.504 17.297 -37.184 1.00 44.95 C \\\\nATOM 1605 CB SER A 199 -45.013 18.600 -39.264 1.00 44.95 C \\\\nATOM 1606 O SER A 199 -44.880 16.278 -36.905 1.00 44.95 O \\\\nATOM 1607 OG SER A 199 -44.858 19.940 -39.677 1.00 44.95 O \\\\nATOM 1608 N MET A 200 -46.827 17.399 -36.996 1.00 45.79 N \\\\nATOM 1609 CA MET A 200 -47.737 16.340 -36.510 1.00 45.79 C \\\\nATOM 1610 C MET A 200 -48.777 15.996 -37.591 1.00 45.79 C \\\\nATOM 1611 CB MET A 200 -48.544 16.849 -35.293 1.00 45.79 C \\\\nATOM 1612 O MET A 200 -49.139 16.913 -38.320 1.00 45.79 O \\\\nATOM 1613 CG MET A 200 -47.745 17.422 -34.119 1.00 45.79 C \\\\nATOM 1614 SD MET A 200 -48.821 18.013 -32.777 1.00 45.79 S \\\\nATOM 1615 CE MET A 200 -47.596 18.699 -31.636 1.00 45.79 C \\\\nATOM 1616 N ASP A 201 -49.331 14.771 -37.623 1.00 46.67 N \\\\nATOM 1617 CA ASP A 201 -50.800 14.576 -37.689 1.00 46.67 C \\\\nATOM 1618 C ASP A 201 -51.266 13.129 -37.369 1.00 46.67 C \\\\nATOM 1619 CB ASP A 201 -51.455 15.079 -38.999 1.00 46.67 C \\\\nATOM 1620 O ASP A 201 -50.450 12.229 -37.159 1.00 46.67 O \\\\nATOM 1621 CG ASP A 201 -52.680 15.954 -38.674 1.00 46.67 C \\\\nATOM 1622 OD1 ASP A 201 -53.380 15.616 -37.687 1.00 46.67 O \\\\nATOM 1623 OD2 ASP A 201 -52.926 16.935 -39.408 1.00 46.67 O \\\\nATOM 1624 N ALA A 202 -52.585 12.935 -37.251 1.00 43.71 N \\\\nATOM 1625 CA ALA A 202 -53.251 11.820 -36.563 1.00 43.71 C \\\\nATOM 1626 C ALA A 202 -53.674 10.601 -37.424 1.00 43.71 C \\\\nATOM 1627 CB ALA A 202 -54.477 12.426 -35.864 1.00 43.71 C \\\\nATOM 1628 O ALA A 202 -53.850 10.694 -38.636 1.00 43.71 O \\\\nATOM 1629 N GLY A 203 -53.959 9.462 -36.762 1.00 40.70 N \\\\nATOM 1630 CA GLY A 203 -54.671 8.322 -37.373 1.00 40.70 C \\\\nATOM 1631 C GLY A 203 -54.584 6.979 -36.622 1.00 40.70 C \\\\nATOM 1632 O GLY A 203 -53.621 6.241 -36.779 1.00 40.70 O \\\\nATOM 1633 N SER A 204 -55.635 6.626 -35.875 1.00 42.76 N \\\\nATOM 1634 CA SER A 204 -55.953 5.263 -35.375 1.00 42.76 C \\\\nATOM 1635 C SER A 204 -57.215 4.749 -36.114 1.00 42.76 C \\\\nATOM 1636 CB SER A 204 -56.175 5.346 -33.854 1.00 42.76 C \\\\nATOM 1637 O SER A 204 -57.909 5.613 -36.658 1.00 42.76 O \\\\nATOM 1638 OG SER A 204 -54.953 5.182 -33.165 1.00 42.76 O \\\\nATOM 1639 N PRO A 205 -57.600 3.440 -36.129 1.00 46.18 N \\\\nATOM 1640 CA PRO A 205 -57.311 2.419 -35.103 1.00 46.18 C \\\\nATOM 1641 C PRO A 205 -57.072 0.946 -35.563 1.00 46.18 C \\\\nATOM 1642 CB PRO A 205 -58.634 2.448 -34.321 1.00 46.18 C \\\\nATOM 1643 O PRO A 205 -57.305 0.567 -36.703 1.00 46.18 O \\\\nATOM 1644 CG PRO A 205 -59.689 2.523 -35.436 1.00 46.18 C \\\\nATOM 1645 CD PRO A 205 -58.931 3.098 -36.637 1.00 46.18 C \\\\nATOM 1646 N ASN A 206 -56.707 0.107 -34.579 1.00 39.37 N \\\\nATOM 1647 CA ASN A 206 -57.019 -1.327 -34.383 1.00 39.37 C \\\\nATOM 1648 C ASN A 206 -57.092 -2.311 -35.573 1.00 39.37 C \\\\nATOM 1649 CB ASN A 206 -58.360 -1.430 -33.622 1.00 39.37 C \\\\nATOM 1650 O ASN A 206 -58.089 -2.336 -36.285 1.00 39.37 O \\\\nATOM 1651 CG ASN A 206 -58.338 -0.871 -32.217 1.00 39.37 C \\\\nATOM 1652 ND2 ASN A 206 -59.478 -0.807 -31.571 1.00 39.37 N \\\\nATOM 1653 OD1 ASN A 206 -57.317 -0.484 -31.679 1.00 39.37 O \\\\nATOM 1654 N LEU A 207 -56.196 -3.312 -35.564 1.00 44.78 N \\\\nATOM 1655 CA LEU A 207 -56.487 -4.720 -35.904 1.00 44.78 C \\\\nATOM 1656 C LEU A 207 -55.433 -5.648 -35.248 1.00 44.78 C \\\\nATOM 1657 CB LEU A 207 -56.518 -4.928 -37.441 1.00 44.78 C \\\\nATOM 1658 O LEU A 207 -54.266 -5.622 -35.625 1.00 44.78 O \\\\nATOM 1659 CG LEU A 207 -57.917 -4.971 -38.099 1.00 44.78 C \\\\nATOM 1660 CD1 LEU A 207 -57.771 -4.972 -39.620 1.00 44.78 C \\\\nATOM 1661 CD2 LEU A 207 -58.716 -6.216 -37.699 1.00 44.78 C \\\\nATOM 1662 N SER A 208 -55.842 -6.478 -34.284 1.00 40.73 N \\\\nATOM 1663 CA SER A 208 -55.055 -7.621 -33.762 1.00 40.73 C \\\\nATOM 1664 C SER A 208 -55.432 -8.888 -34.557 1.00 40.73 C \\\\nATOM 1665 CB SER A 208 -55.324 -7.826 -32.261 1.00 40.73 C \\\\nATOM 1666 O SER A 208 -56.579 -8.945 -35.011 1.00 40.73 O \\\\nATOM 1667 OG SER A 208 -55.350 -6.605 -31.544 1.00 40.73 O \\\\nATOM 1668 N PRO A 209 -54.570 -9.926 -34.702 1.00 44.83 N \\\\nATOM 1669 CA PRO A 209 -54.400 -10.888 -33.596 1.00 44.83 C \\\\nATOM 1670 C PRO A 209 -53.067 -11.690 -33.521 1.00 44.83 C \\\\nATOM 1671 CB PRO A 209 -55.548 -11.872 -33.862 1.00 44.83 C \\\\nATOM 1672 O PRO A 209 -52.260 -11.716 -34.441 1.00 44.83 O \\\\nATOM 1673 CG PRO A 209 -55.517 -12.030 -35.384 1.00 44.83 C \\\\nATOM 1674 CD PRO A 209 -54.779 -10.779 -35.876 1.00 44.83 C \\\\nATOM 1675 N ASN A 210 -52.975 -12.466 -32.431 1.00 41.10 N \\\\nATOM 1676 CA ASN A 210 -52.140 -13.654 -32.163 1.00 41.10 C \\\\nATOM 1677 C ASN A 210 -50.635 -13.492 -31.825 1.00 41.10 C \\\\nATOM 1678 CB ASN A 210 -52.397 -14.760 -33.202 1.00 41.10 C \\\\nATOM 1679 O ASN A 210 -49.853 -13.017 -32.644 1.00 41.10 O \\\\nATOM 1680 CG ASN A 210 -53.775 -15.385 -33.076 1.00 41.10 C \\\\nATOM 1681 ND2 ASN A 210 -54.098 -16.329 -33.926 1.00 41.10 N \\\\nATOM 1682 OD1 ASN A 210 -54.574 -15.061 -32.210 1.00 41.10 O \\\\nATOM 1683 N PRO A 211 -50.195 -13.989 -30.644 1.00 40.72 N \\\\nATOM 1684 CA PRO A 211 -48.784 -14.075 -30.279 1.00 40.72 C \\\\nATOM 1685 C PRO A 211 -48.138 -15.368 -30.802 1.00 40.72 C \\\\nATOM 1686 CB PRO A 211 -48.777 -14.031 -28.748 1.00 40.72 C \\\\nATOM 1687 O PRO A 211 -48.693 -16.457 -30.648 1.00 40.72 O \\\\nATOM 1688 CG PRO A 211 -50.056 -14.780 -28.371 1.00 40.72 C \\\\nATOM 1689 CD PRO A 211 -51.010 -14.460 -29.524 1.00 40.72 C \\\\nATOM 1690 N MET A 212 -46.921 -15.265 -31.338 1.00 42.15 N \\\\nATOM 1691 CA MET A 212 -46.016 -16.412 -31.467 1.00 42.15 C \\\\nATOM 1692 C MET A 212 -45.120 -16.483 -30.229 1.00 42.15 C \\\\nATOM 1693 CB MET A 212 -45.197 -16.341 -32.766 1.00 42.15 C \\\\nATOM 1694 O MET A 212 -44.534 -15.481 -29.822 1.00 42.15 O \\\\nATOM 1695 CG MET A 212 -46.095 -16.597 -33.984 1.00 42.15 C \\\\nATOM 1696 SD MET A 212 -45.256 -16.690 -35.591 1.00 42.15 S \\\\nATOM 1697 CE MET A 212 -44.234 -18.174 -35.381 1.00 42.15 C \\\\nATOM 1698 N SER A 213 -45.035 -17.666 -29.621 1.00 39.51 N \\\\nATOM 1699 CA SER A 213 -44.201 -17.926 -28.446 1.00 39.51 C \\\\nATOM 1700 C SER A 213 -42.723 -17.623 -28.732 1.00 39.51 C \\\\nATOM 1701 CB SER A 213 -44.315 -19.400 -28.044 1.00 39.51 C \\\\nATOM 1702 O SER A 213 -42.234 -18.034 -29.788 1.00 39.51 O \\\\nATOM 1703 OG SER A 213 -45.673 -19.802 -27.981 1.00 39.51 O \\\\nATOM 1704 N PRO A 214 -41.972 -16.991 -27.810 1.00 42.72 N \\\\nATOM 1705 CA PRO A 214 -40.527 -16.881 -27.955 1.00 42.72 C \\\\nATOM 1706 C PRO A 214 -39.909 -18.278 -27.898 1.00 42.72 C \\\\nATOM 1707 CB PRO A 214 -40.030 -16.000 -26.800 1.00 42.72 C \\\\nATOM 1708 O PRO A 214 -40.210 -19.057 -26.990 1.00 42.72 O \\\\nATOM 1709 CG PRO A 214 -41.299 -15.382 -26.214 1.00 42.72 C \\\\nATOM 1710 CD PRO A 214 -42.392 -16.393 -26.555 1.00 42.72 C \\\\nATOM 1711 N ALA A 215 -39.018 -18.593 -28.837 1.00 38.54 N \\\\nATOM 1712 CA ALA A 215 -38.164 -19.761 -28.699 1.00 38.54 C \\\\nATOM 1713 C ALA A 215 -37.263 -19.558 -27.471 1.00 38.54 C \\\\nATOM 1714 CB ALA A 215 -37.366 -19.964 -29.993 1.00 38.54 C \\\\nATOM 1715 O ALA A 215 -36.411 -18.668 -27.457 1.00 38.54 O \\\\nATOM 1716 N HIS A 216 -37.455 -20.375 -26.433 1.00 40.42 N \\\\nATOM 1717 CA HIS A 216 -36.520 -20.447 -25.316 1.00 40.42 C \\\\nATOM 1718 C HIS A 216 -35.209 -21.071 -25.806 1.00 40.42 C \\\\nATOM 1719 CB HIS A 216 -37.123 -21.222 -24.129 1.00 40.42 C \\\\nATOM 1720 O HIS A 216 -35.005 -22.281 -25.704 1.00 40.42 O \\\\nATOM 1721 CG HIS A 216 -37.967 -20.379 -23.206 1.00 40.42 C \\\\nATOM 1722 CD2 HIS A 216 -39.316 -20.482 -22.997 1.00 40.42 C \\\\nATOM 1723 ND1 HIS A 216 -37.497 -19.419 -22.338 1.00 40.42 N \\\\nATOM 1724 CE1 HIS A 216 -38.538 -18.952 -21.629 1.00 40.42 C \\\\nATOM 1725 NE2 HIS A 216 -39.670 -19.572 -21.994 1.00 40.42 N \\\\nATOM 1726 N ASN A 217 -34.301 -20.230 -26.305 1.00 45.94 N \\\\nATOM 1727 CA ASN A 217 -32.886 -20.566 -26.348 1.00 45.94 C \\\\nATOM 1728 C ASN A 217 -32.417 -20.746 -24.900 1.00 45.94 C \\\\nATOM 1729 CB ASN A 217 -32.085 -19.479 -27.098 1.00 45.94 C \\\\nATOM 1730 O ASN A 217 -32.070 -19.777 -24.224 1.00 45.94 O \\\\nATOM 1731 CG ASN A 217 -32.078 -19.656 -28.607 1.00 45.94 C \\\\nATOM 1732 ND2 ASN A 217 -31.390 -18.796 -29.321 1.00 45.94 N \\\\nATOM 1733 OD1 ASN A 217 -32.661 -20.566 -29.167 1.00 45.94 O \\\\nATOM 1734 N ASN A 218 -32.422 -21.996 -24.430 1.00 48.29 N \\\\nATOM 1735 CA ASN A 218 -31.732 -22.420 -23.215 1.00 48.29 C \\\\nATOM 1736 C ASN A 218 -30.218 -22.322 -23.454 1.00 48.29 C \\\\nATOM 1737 CB ASN A 218 -32.196 -23.836 -22.795 1.00 48.29 C \\\\nATOM 1738 O ASN A 218 -29.524 -23.321 -23.636 1.00 48.29 O \\\\nATOM 1739 CG ASN A 218 -33.261 -23.865 -21.712 1.00 48.29 C \\\\nATOM 1740 ND2 ASN A 218 -33.691 -25.044 -21.328 1.00 48.29 N \\\\nATOM 1741 OD1 ASN A 218 -33.708 -22.868 -21.174 1.00 48.29 O \\\\nATOM 1742 N LEU A 219 -29.712 -21.090 -23.470 1.00 60.32 N \\\\nATOM 1743 CA LEU A 219 -28.303 -20.815 -23.246 1.00 60.32 C \\\\nATOM 1744 C LEU A 219 -27.998 -21.275 -21.819 1.00 60.32 C \\\\nATOM 1745 CB LEU A 219 -28.035 -19.313 -23.455 1.00 60.32 C \\\\nATOM 1746 O LEU A 219 -28.474 -20.677 -20.854 1.00 60.32 O \\\\nATOM 1747 CG LEU A 219 -28.042 -18.894 -24.937 1.00 60.32 C \\\\nATOM 1748 CD1 LEU A 219 -28.221 -17.382 -25.062 1.00 60.32 C \\\\nATOM 1749 CD2 LEU A 219 -26.732 -19.278 -25.630 1.00 60.32 C \\\\nATOM 1750 N ASP A 220 -27.247 -22.368 -21.699 1.00 74.45 N \\\\nATOM 1751 CA ASP A 220 -26.793 -22.909 -20.419 1.00 74.45 C \\\\nATOM 1752 C ASP A 220 -25.707 -21.976 -19.855 1.00 74.45 C \\\\nATOM 1753 CB ASP A 220 -26.366 -24.375 -20.612 1.00 74.45 C \\\\nATOM 1754 O ASP A 220 -24.509 -22.128 -20.106 1.00 74.45 O \\\\nATOM 1755 CG ASP A 220 -26.139 -25.137 -19.300 1.00 74.45 C \\\\nATOM 1756 OD1 ASP A 220 -26.610 -24.684 -18.235 1.00 74.45 O \\\\nATOM 1757 OD2 ASP A 220 -25.480 -26.202 -19.357 1.00 74.45 O \\\\nATOM 1758 N LEU A 221 -26.177 -20.912 -19.198 1.00 81.69 N \\\\nATOM 1759 CA LEU A 221 -25.384 -19.817 -18.652 1.00 81.69 C \\\\nATOM 1760 C LEU A 221 -24.868 -20.190 -17.261 1.00 81.69 C \\\\nATOM 1761 CB LEU A 221 -26.244 -18.539 -18.591 1.00 81.69 C \\\\nATOM 1762 O LEU A 221 -25.641 -20.307 -16.308 1.00 81.69 O \\\\nATOM 1763 CG LEU A 221 -26.532 -17.876 -19.951 1.00 81.69 C \\\\nATOM 1764 CD1 LEU A 221 -27.616 -16.809 -19.796 1.00 81.69 C \\\\nATOM 1765 CD2 LEU A 221 -25.300 -17.189 -20.537 1.00 81.69 C \\\\nATOM 1766 N GLN A 222 -23.551 -20.314 -17.121 1.00 85.05 N \\\\nATOM 1767 CA GLN A 222 -22.922 -20.623 -15.844 1.00 85.05 C \\\\nATOM 1768 C GLN A 222 -22.578 -19.327 -15.078 1.00 85.05 C \\\\nATOM 1769 CB GLN A 222 -21.723 -21.549 -16.088 1.00 85.05 C \\\\nATOM 1770 O GLN A 222 -21.875 -18.469 -15.616 1.00 85.05 O \\\\nATOM 1771 CG GLN A 222 -21.146 -22.068 -14.764 1.00 85.05 C \\\\nATOM 1772 CD GLN A 222 -20.201 -23.256 -14.935 1.00 85.05 C \\\\nATOM 1773 NE2 GLN A 222 -19.224 -23.405 -14.071 1.00 85.05 N \\\\nATOM 1774 OE1 GLN A 222 -20.361 -24.133 -15.776 1.00 85.05 O \\\\nATOM 1775 N PRO A 223 -23.056 -19.142 -13.830 1.00 90.37 N \\\\nATOM 1776 CA PRO A 223 -22.756 -17.950 -13.042 1.00 90.37 C \\\\nATOM 1777 C PRO A 223 -21.366 -18.020 -12.394 1.00 90.37 C \\\\nATOM 1778 CB PRO A 223 -23.877 -17.858 -12.003 1.00 90.37 C \\\\nATOM 1779 O PRO A 223 -21.036 -18.970 -11.681 1.00 90.37 O \\\\nATOM 1780 CG PRO A 223 -24.265 -19.319 -11.776 1.00 90.37 C \\\\nATOM 1781 CD PRO A 223 -24.053 -19.958 -13.149 1.00 90.37 C \\\\nATOM 1782 N VAL A 224 -20.577 -16.961 -12.571 1.00 90.45 N \\\\nATOM 1783 CA VAL A 224 -19.236 -16.791 -12.000 1.00 90.45 C \\\\nATOM 1784 C VAL A 224 -19.241 -15.674 -10.963 1.00 90.45 C \\\\nATOM 1785 CB VAL A 224 -18.185 -16.520 -13.094 1.00 90.45 C \\\\nATOM 1786 O VAL A 224 -19.332 -14.489 -11.293 1.00 90.45 O \\\\nATOM 1787 CG1 VAL A 224 -16.787 -16.560 -12.468 1.00 90.45 C \\\\nATOM 1788 CG2 VAL A 224 -18.242 -17.587 -14.185 1.00 90.45 C \\\\nATOM 1789 N THR A 225 -19.119 -16.047 -9.690 1.00 90.96 N \\\\nATOM 1790 CA THR A 225 -19.107 -15.113 -8.558 1.00 90.96 C \\\\nATOM 1791 C THR A 225 -17.708 -14.574 -8.245 1.00 90.96 C \\\\nATOM 1792 CB THR A 225 -19.718 -15.750 -7.299 1.00 90.96 C \\\\nATOM 1793 O THR A 225 -16.707 -15.306 -8.235 1.00 90.96 O \\\\nATOM 1794 CG2 THR A 225 -21.223 -15.974 -7.443 1.00 90.96 C \\\\nATOM 1795 OG1 THR A 225 -19.143 -17.012 -7.043 1.00 90.96 O \\\\nATOM 1796 N TYR A 226 -17.656 -13.279 -7.920 1.00 91.36 N \\\\nATOM 1797 CA TYR A 226 -16.485 -12.645 -7.317 1.00 91.36 C \\\\nATOM 1798 C TYR A 226 -16.177 -13.268 -5.947 1.00 91.36 C \\\\nATOM 1799 CB TYR A 226 -16.729 -11.137 -7.179 1.00 91.36 C \\\\nATOM 1800 O TYR A 226 -17.081 -13.659 -5.205 1.00 91.36 O \\\\nATOM 1801 CG TYR A 226 -15.526 -10.357 -6.675 1.00 91.36 C \\\\nATOM 1802 CD1 TYR A 226 -15.400 -10.011 -5.314 1.00 91.36 C \\\\nATOM 1803 CD2 TYR A 226 -14.536 -9.953 -7.586 1.00 91.36 C \\\\nATOM 1804 CE1 TYR A 226 -14.290 -9.258 -4.874 1.00 91.36 C \\\\nATOM 1805 CE2 TYR A 226 -13.447 -9.174 -7.158 1.00 91.36 C \\\\nATOM 1806 OH TYR A 226 -12.242 -8.086 -5.408 1.00 91.36 O \\\\nATOM 1807 CZ TYR A 226 -13.310 -8.831 -5.798 1.00 91.36 C \\\\nATOM 1808 N CYS A 227 -14.896 -13.343 -5.592 1.00 88.04 N \\\\nATOM 1809 CA CYS A 227 -14.446 -13.685 -4.245 1.00 88.04 C \\\\nATOM 1810 C CYS A 227 -13.320 -12.729 -3.857 1.00 88.04 C \\\\nATOM 1811 CB CYS A 227 -13.971 -15.144 -4.176 1.00 88.04 C \\\\nATOM 1812 O CYS A 227 -12.443 -12.461 -4.673 1.00 88.04 O \\\\nATOM 1813 SG CYS A 227 -15.324 -16.288 -4.590 1.00 88.04 S \\\\nATOM 1814 N GLU A 228 -13.341 -12.228 -2.624 1.00 87.08 N \\\\nATOM 1815 CA GLU A 228 -12.293 -11.333 -2.136 1.00 87.08 C \\\\nATOM 1816 C GLU A 228 -11.044 -12.157 -1.749 1.00 87.08 C \\\\nATOM 1817 CB GLU A 228 -12.835 -10.504 -0.959 1.00 87.08 C \\\\nATOM 1818 O GLU A 228 -11.162 -13.089 -0.945 1.00 87.08 O \\\\nATOM 1819 CG GLU A 228 -12.081 -9.184 -0.760 1.00 87.08 C \\\\nATOM 1820 CD GLU A 228 -12.445 -8.166 -1.847 1.00 87.08 C \\\\nATOM 1821 OE1 GLU A 228 -11.724 -8.084 -2.862 1.00 87.08 O \\\\nATOM 1822 OE2 GLU A 228 -13.462 -7.454 -1.705 1.00 87.08 O \\\\nATOM 1823 N PRO A 229 -9.856 -11.871 -2.307 1.00 91.38 N \\\\nATOM 1824 CA PRO A 229 -8.630 -12.602 -1.993 1.00 91.38 C \\\\nATOM 1825 C PRO A 229 -8.013 -12.151 -0.659 1.00 91.38 C \\\\nATOM 1826 CB PRO A 229 -7.696 -12.322 -3.172 1.00 91.38 C \\\\nATOM 1827 O PRO A 229 -8.198 -11.022 -0.213 1.00 91.38 O \\\\nATOM 1828 CG PRO A 229 -8.092 -10.899 -3.553 1.00 91.38 C \\\\nATOM 1829 CD PRO A 229 -9.602 -10.891 -3.353 1.00 91.38 C \\\\nATOM 1830 N ALA A 230 -7.183 -13.009 -0.054 1.00 90.34 N \\\\nATOM 1831 CA ALA A 230 -6.465 -12.698 1.192 1.00 90.34 C \\\\nATOM 1832 C ALA A 230 -5.456 -11.533 1.066 1.00 90.34 C \\\\nATOM 1833 CB ALA A 230 -5.759 -13.977 1.660 1.00 90.34 C \\\\nATOM 1834 O ALA A 230 -5.130 -10.879 2.056 1.00 90.34 O \\\\nATOM 1835 N PHE A 231 -4.973 -11.272 -0.152 1.00 94.61 N \\\\nATOM 1836 CA PHE A 231 -4.199 -10.086 -0.509 1.00 94.61 C \\\\nATOM 1837 C PHE A 231 -4.930 -9.383 -1.649 1.00 94.61 C \\\\nATOM 1838 CB PHE A 231 -2.775 -10.474 -0.935 1.00 94.61 C \\\\nATOM 1839 O PHE A 231 -5.084 -9.979 -2.715 1.00 94.61 O \\\\nATOM 1840 CG PHE A 231 -1.985 -11.239 0.107 1.00 94.61 C \\\\nATOM 1841 CD1 PHE A 231 -1.300 -10.545 1.119 1.00 94.61 C \\\\nATOM 1842 CD2 PHE A 231 -1.917 -12.644 0.056 1.00 94.61 C \\\\nATOM 1843 CE1 PHE A 231 -0.547 -11.247 2.076 1.00 94.61 C \\\\nATOM 1844 CE2 PHE A 231 -1.170 -13.349 1.017 1.00 94.61 C \\\\nATOM 1845 CZ PHE A 231 -0.486 -12.650 2.027 1.00 94.61 C \\\\nATOM 1846 N TRP A 232 -5.376 -8.142 -1.456 1.00 95.43 N \\\\nATOM 1847 CA TRP A 232 -6.197 -7.431 -2.445 1.00 95.43 C \\\\nATOM 1848 C TRP A 232 -5.375 -6.933 -3.644 1.00 95.43 C \\\\nATOM 1849 CB TRP A 232 -6.971 -6.306 -1.752 1.00 95.43 C \\\\nATOM 1850 O TRP A 232 -5.883 -6.886 -4.766 1.00 95.43 O \\\\nATOM 1851 CG TRP A 232 -6.131 -5.200 -1.196 1.00 95.43 C \\\\nATOM 1852 CD1 TRP A 232 -5.652 -5.120 0.065 1.00 95.43 C \\\\nATOM 1853 CD2 TRP A 232 -5.664 -3.998 -1.878 1.00 95.43 C \\\\nATOM 1854 CE2 TRP A 232 -4.882 -3.233 -0.963 1.00 95.43 C \\\\nATOM 1855 CE3 TRP A 232 -5.831 -3.479 -3.180 1.00 95.43 C \\\\nATOM 1856 NE1 TRP A 232 -4.917 -3.961 0.205 1.00 95.43 N \\\\nATOM 1857 CH2 TRP A 232 -4.469 -1.529 -2.630 1.00 95.43 C \\\\nATOM 1858 CZ2 TRP A 232 -4.287 -2.015 -1.323 1.00 95.43 C \\\\nATOM 1859 CZ3 TRP A 232 -5.238 -2.259 -3.554 1.00 95.43 C \\\\nATOM 1860 N CYS A 233 -4.085 -6.643 -3.443 1.00 97.66 N \\\\nATOM 1861 CA CYS A 233 -3.142 -6.409 -4.533 1.00 97.66 C \\\\nATOM 1862 C CYS A 233 -1.744 -6.980 -4.268 1.00 97.66 C \\\\nATOM 1863 CB CYS A 233 -3.097 -4.915 -4.904 1.00 97.66 C \\\\nATOM 1864 O CYS A 233 -1.371 -7.311 -3.137 1.00 97.66 O \\\\nATOM 1865 SG CYS A 233 -2.220 -3.908 -3.672 1.00 97.66 S \\\\nATOM 1866 N SER A 234 -0.963 -7.073 -5.340 1.00 98.00 N \\\\nATOM 1867 CA SER A 234 0.484 -7.274 -5.297 1.00 98.00 C \\\\nATOM 1868 C SER A 234 1.196 -6.126 -6.021 1.00 98.00 C \\\\nATOM 1869 CB SER A 234 0.855 -8.653 -5.846 1.00 98.00 C \\\\nATOM 1870 O SER A 234 0.656 -5.569 -6.978 1.00 98.00 O \\\\nATOM 1871 OG SER A 234 0.561 -8.773 -7.220 1.00 98.00 O \\\\nATOM 1872 N ILE A 235 2.374 -5.727 -5.534 1.00 98.48 N \\\\nATOM 1873 CA ILE A 235 3.124 -4.561 -6.018 1.00 98.48 C \\\\nATOM 1874 C ILE A 235 4.563 -4.957 -6.337 1.00 98.48 C \\\\nATOM 1875 CB ILE A 235 3.083 -3.380 -5.017 1.00 98.48 C \\\\nATOM 1876 O ILE A 235 5.286 -5.443 -5.467 1.00 98.48 O \\\\nATOM 1877 CG1 ILE A 235 1.628 -3.071 -4.597 1.00 98.48 C \\\\nATOM 1878 CG2 ILE A 235 3.764 -2.146 -5.646 1.00 98.48 C \\\\nATOM 1879 CD1 ILE A 235 1.453 -1.811 -3.745 1.00 98.48 C \\\\nATOM 1880 N SER A 236 5.002 -4.695 -7.566 1.00 98.56 N \\\\nATOM 1881 CA SER A 236 6.394 -4.879 -7.998 1.00 98.56 C \\\\nATOM 1882 C SER A 236 7.045 -3.523 -8.282 1.00 98.56 C \\\\nATOM 1883 CB SER A 236 6.453 -5.806 -9.215 1.00 98.56 C \\\\nATOM 1884 O SER A 236 6.434 -2.671 -8.924 1.00 98.56 O \\\\nATOM 1885 OG SER A 236 5.926 -7.081 -8.879 1.00 98.56 O \\\\nATOM 1886 N TYR A 237 8.271 -3.307 -7.796 1.00 98.69 N \\\\nATOM 1887 CA TYR A 237 9.032 -2.067 -7.999 1.00 98.69 C \\\\nATOM 1888 C TYR A 237 10.047 -2.195 -9.137 1.00 98.69 C \\\\nATOM 1889 CB TYR A 237 9.692 -1.633 -6.680 1.00 98.69 C \\\\nATOM 1890 O TYR A 237 10.666 -3.245 -9.328 1.00 98.69 O \\\\nATOM 1891 CG TYR A 237 10.637 -0.444 -6.789 1.00 98.69 C \\\\nATOM 1892 CD1 TYR A 237 12.003 -0.597 -6.486 1.00 98.69 C \\\\nATOM 1893 CD2 TYR A 237 10.156 0.816 -7.191 1.00 98.69 C \\\\nATOM 1894 CE1 TYR A 237 12.878 0.503 -6.562 1.00 98.69 C \\\\nATOM 1895 CE2 TYR A 237 11.029 1.915 -7.294 1.00 98.69 C \\\\nATOM 1896 OH TYR A 237 13.219 2.844 -6.988 1.00 98.69 O \\\\nATOM 1897 CZ TYR A 237 12.391 1.765 -6.962 1.00 98.69 C \\\\nATOM 1898 N TYR A 238 10.217 -1.103 -9.881 1.00 98.77 N \\\\nATOM 1899 CA TYR A 238 11.071 -1.011 -11.053 1.00 98.77 C \\\\nATOM 1900 C TYR A 238 11.893 0.282 -11.053 1.00 98.77 C \\\\nATOM 1901 CB TYR A 238 10.215 -1.095 -12.322 1.00 98.77 C \\\\nATOM 1902 O TYR A 238 11.424 1.369 -10.693 1.00 98.77 O \\\\nATOM 1903 CG TYR A 238 9.557 -2.438 -12.582 1.00 98.77 C \\\\nATOM 1904 CD1 TYR A 238 10.127 -3.335 -13.507 1.00 98.77 C \\\\nATOM 1905 CD2 TYR A 238 8.351 -2.771 -11.935 1.00 98.77 C \\\\nATOM 1906 CE1 TYR A 238 9.513 -4.577 -13.760 1.00 98.77 C \\\\nATOM 1907 CE2 TYR A 238 7.751 -4.023 -12.163 1.00 98.77 C \\\\nATOM 1908 OH TYR A 238 7.774 -6.155 -13.249 1.00 98.77 O \\\\nATOM 1909 CZ TYR A 238 8.338 -4.934 -13.063 1.00 98.77 C \\\\nATOM 1910 N GLU A 239 13.128 0.159 -11.527 1.00 98.62 N \\\\nATOM 1911 CA GLU A 239 14.019 1.264 -11.862 1.00 98.62 C \\\\nATOM 1912 C GLU A 239 14.323 1.165 -13.362 1.00 98.62 C \\\\nATOM 1913 CB GLU A 239 15.284 1.228 -10.979 1.00 98.62 C \\\\nATOM 1914 O GLU A 239 14.958 0.211 -13.810 1.00 98.62 O \\\\nATOM 1915 CG GLU A 239 14.940 1.495 -9.500 1.00 98.62 C \\\\nATOM 1916 CD GLU A 239 16.132 1.483 -8.527 1.00 98.62 C \\\\nATOM 1917 OE1 GLU A 239 15.922 1.704 -7.311 1.00 98.62 O \\\\nATOM 1918 OE2 GLU A 239 17.306 1.282 -8.916 1.00 98.62 O \\\\nATOM 1919 N LEU A 240 13.834 2.127 -14.153 1.00 98.06 N \\\\nATOM 1920 CA LEU A 240 13.823 2.051 -15.621 1.00 98.06 C \\\\nATOM 1921 C LEU A 240 13.079 0.792 -16.117 1.00 98.06 C \\\\nATOM 1922 CB LEU A 240 15.248 2.233 -16.192 1.00 98.06 C \\\\nATOM 1923 O LEU A 240 11.916 0.600 -15.776 1.00 98.06 O \\\\nATOM 1924 CG LEU A 240 15.969 3.510 -15.728 1.00 98.06 C \\\\nATOM 1925 CD1 LEU A 240 17.434 3.448 -16.154 1.00 98.06 C \\\\nATOM 1926 CD2 LEU A 240 15.350 4.776 -16.327 1.00 98.06 C \\\\nATOM 1927 N ASN A 241 13.710 -0.073 -16.912 1.00 97.14 N \\\\nATOM 1928 CA ASN A 241 13.154 -1.360 -17.346 1.00 97.14 C \\\\nATOM 1929 C ASN A 241 13.502 -2.533 -16.405 1.00 97.14 C \\\\nATOM 1930 CB ASN A 241 13.596 -1.633 -18.797 1.00 97.14 C \\\\nATOM 1931 O ASN A 241 13.069 -3.658 -16.655 1.00 97.14 O \\\\nATOM 1932 CG ASN A 241 15.097 -1.813 -18.965 1.00 97.14 C \\\\nATOM 1933 ND2 ASN A 241 15.528 -2.374 -20.069 1.00 97.14 N \\\\nATOM 1934 OD1 ASN A 241 15.903 -1.420 -18.136 1.00 97.14 O \\\\nATOM 1935 N GLN A 242 14.276 -2.305 -15.340 1.00 97.90 N \\\\nATOM 1936 CA GLN A 242 14.739 -3.357 -14.439 1.00 97.90 C \\\\nATOM 1937 C GLN A 242 13.834 -3.473 -13.211 1.00 97.90 C \\\\nATOM 1938 CB GLN A 242 16.203 -3.092 -14.058 1.00 97.90 C \\\\nATOM 1939 O GLN A 242 13.608 -2.500 -12.494 1.00 97.90 O \\\\nATOM 1940 CG GLN A 242 16.783 -4.233 -13.207 1.00 97.90 C \\\\nATOM 1941 CD GLN A 242 18.248 -4.032 -12.846 1.00 97.90 C \\\\nATOM 1942 NE2 GLN A 242 18.831 -4.925 -12.081 1.00 97.90 N \\\\nATOM 1943 OE1 GLN A 242 18.908 -3.084 -13.238 1.00 97.90 O \\\\nATOM 1944 N ARG A 243 13.365 -4.690 -12.920 1.00 98.06 N \\\\nATOM 1945 CA ARG A 243 12.677 -5.004 -11.663 1.00 98.06 C \\\\nATOM 1946 C ARG A 243 13.668 -4.998 -10.495 1.00 98.06 C \\\\nATOM 1947 CB ARG A 243 11.953 -6.346 -11.809 1.00 98.06 C \\\\nATOM 1948 O ARG A 243 14.748 -5.576 -10.598 1.00 98.06 O \\\\nATOM 1949 CG ARG A 243 11.106 -6.643 -10.571 1.00 98.06 C \\\\nATOM 1950 CD ARG A 243 10.301 -7.925 -10.764 1.00 98.06 C \\\\nATOM 1951 NE ARG A 243 9.956 -8.477 -9.451 1.00 98.06 N \\\\nATOM 1952 NH1 ARG A 243 8.193 -9.836 -10.058 1.00 98.06 N \\\\nATOM 1953 NH2 ARG A 243 8.897 -9.730 -7.940 1.00 98.06 N \\\\nATOM 1954 CZ ARG A 243 9.014 -9.349 -9.171 1.00 98.06 C \\\\nATOM 1955 N VAL A 244 13.291 -4.378 -9.379 1.00 98.38 N \\\\nATOM 1956 CA VAL A 244 14.143 -4.200 -8.196 1.00 98.38 C \\\\nATOM 1957 C VAL A 244 13.391 -4.645 -6.941 1.00 98.38 C \\\\nATOM 1958 CB VAL A 244 14.626 -2.736 -8.101 1.00 98.38 C \\\\nATOM 1959 O VAL A 244 12.381 -4.055 -6.570 1.00 98.38 O \\\\nATOM 1960 CG1 VAL A 244 15.439 -2.476 -6.827 1.00 98.38 C \\\\nATOM 1961 CG2 VAL A 244 15.519 -2.366 -9.293 1.00 98.38 C \\\\nATOM 1962 N GLY A 245 13.918 -5.665 -6.260 1.00 96.94 N \\\\nATOM 1963 CA GLY A 245 13.327 -6.223 -5.041 1.00 96.94 C \\\\nATOM 1964 C GLY A 245 12.210 -7.251 -5.269 1.00 96.94 C \\\\nATOM 1965 O GLY A 245 11.853 -7.617 -6.394 1.00 96.94 O \\\\nATOM 1966 N GLU A 246 11.680 -7.746 -4.153 1.00 96.05 N \\\\nATOM 1967 CA GLU A 246 10.594 -8.728 -4.106 1.00 96.05 C \\\\nATOM 1968 C GLU A 246 9.227 -8.084 -4.399 1.00 96.05 C \\\\nATOM 1969 CB GLU A 246 10.600 -9.438 -2.742 1.00 96.05 C \\\\nATOM 1970 O GLU A 246 9.067 -6.864 -4.327 1.00 96.05 O \\\\nATOM 1971 CG GLU A 246 11.927 -10.178 -2.493 1.00 96.05 C \\\\nATOM 1972 CD GLU A 246 11.932 -10.976 -1.182 1.00 96.05 C \\\\nATOM 1973 OE1 GLU A 246 12.596 -12.035 -1.169 1.00 96.05 O \\\\nATOM 1974 OE2 GLU A 246 11.300 -10.506 -0.211 1.00 96.05 O \\\\nATOM 1975 N THR A 247 8.223 -8.900 -4.741 1.00 97.28 N \\\\nATOM 1976 CA THR A 247 6.836 -8.416 -4.842 1.00 97.28 C \\\\nATOM 1977 C THR A 247 6.261 -8.242 -3.439 1.00 97.28 C \\\\nATOM 1978 CB THR A 247 5.942 -9.364 -5.659 1.00 97.28 C \\\\nATOM 1979 O THR A 247 6.203 -9.197 -2.663 1.00 97.28 O \\\\nATOM 1980 CG2 THR A 247 4.483 -8.934 -5.724 1.00 97.28 C \\\\nATOM 1981 OG1 THR A 247 6.361 -9.404 -7.003 1.00 97.28 O \\\\nATOM 1982 N PHE A 248 5.779 -7.043 -3.130 1.00 97.00 N \\\\nATOM 1983 CA PHE A 248 5.022 -6.783 -1.912 1.00 97.00 C \\\\nATOM 1984 C PHE A 248 3.574 -7.265 -2.077 1.00 97.00 C \\\\nATOM 1985 CB PHE A 248 5.102 -5.290 -1.588 1.00 97.00 C \\\\nATOM 1986 O PHE A 248 2.968 -7.046 -3.124 1.00 97.00 O \\\\nATOM 1987 CG PHE A 248 4.498 -4.937 -0.248 1.00 97.00 C \\\\nATOM 1988 CD1 PHE A 248 3.108 -4.751 -0.124 1.00 97.00 C \\\\nATOM 1989 CD2 PHE A 248 5.327 -4.822 0.884 1.00 97.00 C \\\\nATOM 1990 CE1 PHE A 248 2.550 -4.462 1.132 1.00 97.00 C \\\\nATOM 1991 CE2 PHE A 248 4.771 -4.501 2.134 1.00 97.00 C \\\\nATOM 1992 CZ PHE A 248 3.383 -4.322 2.254 1.00 97.00 C \\\\nATOM 1993 N HIS A 249 2.996 -7.886 -1.048 1.00 97.02 N \\\\nATOM 1994 CA HIS A 249 1.628 -8.415 -1.075 1.00 97.02 C \\\\nATOM 1995 C HIS A 249 0.777 -7.718 -0.006 1.00 97.02 C \\\\nATOM 1996 CB HIS A 249 1.668 -9.938 -0.893 1.00 97.02 C \\\\nATOM 1997 O HIS A 249 1.065 -7.816 1.186 1.00 97.02 O \\\\nATOM 1998 CG HIS A 249 2.379 -10.664 -2.010 1.00 97.02 C \\\\nATOM 1999 CD2 HIS A 249 1.784 -11.303 -3.065 1.00 97.02 C \\\\nATOM 2000 ND1 HIS A 249 3.740 -10.819 -2.165 1.00 97.02 N \\\\nATOM 2001 CE1 HIS A 249 3.954 -11.537 -3.277 1.00 97.02 C \\\\nATOM 2002 NE2 HIS A 249 2.791 -11.844 -3.870 1.00 97.02 N \\\\nATOM 2003 N ALA A 250 -0.265 -6.997 -0.425 1.00 95.01 N \\\\nATOM 2004 CA ALA A 250 -1.051 -6.142 0.459 1.00 95.01 C \\\\nATOM 2005 C ALA A 250 -2.266 -6.885 1.031 1.00 95.01 C \\\\nATOM 2006 CB ALA A 250 -1.460 -4.890 -0.323 1.00 95.01 C \\\\nATOM 2007 O ALA A 250 -3.233 -7.147 0.317 1.00 95.01 O \\\\nATOM 2008 N SER A 251 -2.227 -7.219 2.324 1.00 91.07 N \\\\nATOM 2009 CA SER A 251 -3.373 -7.794 3.047 1.00 91.07 C \\\\nATOM 2010 C SER A 251 -4.229 -6.731 3.737 1.00 91.07 C \\\\nATOM 2011 CB SER A 251 -2.896 -8.827 4.069 1.00 91.07 C \\\\nATOM 2012 O SER A 251 -5.447 -6.868 3.805 1.00 91.07 O \\\\nATOM 2013 OG SER A 251 -1.964 -8.254 4.975 1.00 91.07 O \\\\nATOM 2014 N GLN A 252 -3.615 -5.649 4.226 1.00 90.73 N \\\\nATOM 2015 CA GLN A 252 -4.331 -4.580 4.924 1.00 90.73 C \\\\nATOM 2016 C GLN A 252 -5.089 -3.667 3.945 1.00 90.73 C \\\\nATOM 2017 CB GLN A 252 -3.369 -3.767 5.810 1.00 90.73 C \\\\nATOM 2018 O GLN A 252 -4.523 -3.317 2.904 1.00 90.73 O \\\\nATOM 2019 CG GLN A 252 -2.758 -4.604 6.947 1.00 90.73 C \\\\nATOM 2020 CD GLN A 252 -3.801 -5.213 7.884 1.00 90.73 C \\\\nATOM 2021 NE2 GLN A 252 -3.472 -6.274 8.586 1.00 90.73 N \\\\nATOM 2022 OE1 GLN A 252 -4.936 -4.780 7.987 1.00 90.73 O \\\\nATOM 2023 N PRO A 253 -6.313 -3.194 4.272 1.00 90.20 N \\\\nATOM 2024 CA PRO A 253 -7.105 -2.315 3.397 1.00 90.20 C \\\\nATOM 2025 C PRO A 253 -6.448 -0.966 3.070 1.00 90.20 C \\\\nATOM 2026 CB PRO A 253 -8.428 -2.075 4.136 1.00 90.20 C \\\\nATOM 2027 O PRO A 253 -6.895 -0.256 2.175 1.00 90.20 O \\\\nATOM 2028 CG PRO A 253 -8.556 -3.278 5.064 1.00 90.20 C \\\\nATOM 2029 CD PRO A 253 -7.107 -3.576 5.437 1.00 90.20 C \\\\nATOM 2030 N SER A 254 -5.403 -0.580 3.802 1.00 93.37 N \\\\nATOM 2031 CA SER A 254 -4.603 0.618 3.560 1.00 93.37 C \\\\nATOM 2032 C SER A 254 -3.127 0.267 3.695 1.00 93.37 C \\\\nATOM 2033 CB SER A 254 -5.004 1.713 4.557 1.00 93.37 C \\\\nATOM 2034 O SER A 254 -2.726 -0.324 4.692 1.00 93.37 O \\\\nATOM 2035 OG SER A 254 -4.131 2.832 4.511 1.00 93.37 O \\\\nATOM 2036 N MET A 255 -2.311 0.706 2.741 1.00 95.32 N \\\\nATOM 2037 CA MET A 255 -0.854 0.588 2.792 1.00 95.32 C \\\\nATOM 2038 C MET A 255 -0.169 1.840 2.233 1.00 95.32 C \\\\nATOM 2039 CB MET A 255 -0.395 -0.682 2.060 1.00 95.32 C \\\\nATOM 2040 O MET A 255 -0.796 2.671 1.576 1.00 95.32 O \\\\nATOM 2041 CG MET A 255 -0.550 -0.591 0.534 1.00 95.32 C \\\\nATOM 2042 SD MET A 255 0.361 -1.848 -0.389 1.00 95.32 S \\\\nATOM 2043 CE MET A 255 2.074 -1.433 0.046 1.00 95.32 C \\\\nATOM 2044 N THR A 256 1.135 1.974 2.461 1.00 97.98 N \\\\nATOM 2045 CA THR A 256 1.963 3.043 1.885 1.00 97.98 C \\\\nATOM 2046 C THR A 256 3.144 2.443 1.129 1.00 97.98 C \\\\nATOM 2047 CB THR A 256 2.449 4.016 2.971 1.00 97.98 C \\\\nATOM 2048 O THR A 256 3.807 1.546 1.639 1.00 97.98 O \\\\nATOM 2049 CG2 THR A 256 3.014 5.307 2.385 1.00 97.98 C \\\\nATOM 2050 OG1 THR A 256 1.371 4.392 3.804 1.00 97.98 O \\\\nATOM 2051 N VAL A 257 3.434 2.942 -0.070 1.00 98.59 N \\\\nATOM 2052 CA VAL A 257 4.696 2.681 -0.775 1.00 98.59 C \\\\nATOM 2053 C VAL A 257 5.546 3.939 -0.637 1.00 98.59 C \\\\nATOM 2054 CB VAL A 257 4.466 2.311 -2.252 1.00 98.59 C \\\\nATOM 2055 O VAL A 257 5.147 4.992 -1.136 1.00 98.59 O \\\\nATOM 2056 CG1 VAL A 257 5.791 1.898 -2.897 1.00 98.59 C \\\\nATOM 2057 CG2 VAL A 257 3.451 1.175 -2.436 1.00 98.59 C \\\\nATOM 2058 N ASP A 258 6.672 3.861 0.073 1.00 98.59 N \\\\nATOM 2059 CA ASP A 258 7.464 5.030 0.481 1.00 98.59 C \\\\nATOM 2060 C ASP A 258 8.975 4.871 0.236 1.00 98.59 C \\\\nATOM 2061 CB ASP A 258 7.095 5.455 1.918 1.00 98.59 C \\\\nATOM 2062 O ASP A 258 9.464 3.803 -0.117 1.00 98.59 O \\\\nATOM 2063 CG ASP A 258 7.618 4.573 3.055 1.00 98.59 C \\\\nATOM 2064 OD1 ASP A 258 8.842 4.336 3.109 1.00 98.59 O \\\\nATOM 2065 OD2 ASP A 258 6.856 4.304 4.015 1.00 98.59 O \\\\nATOM 2066 N GLY A 259 9.722 5.970 0.356 1.00 98.35 N \\\\nATOM 2067 CA GLY A 259 11.163 6.037 0.098 1.00 98.35 C \\\\nATOM 2068 C GLY A 259 12.046 5.753 1.317 1.00 98.35 C \\\\nATOM 2069 O GLY A 259 13.248 6.001 1.246 1.00 98.35 O \\\\nATOM 2070 N PHE A 260 11.484 5.287 2.436 1.00 97.98 N \\\\nATOM 2071 CA PHE A 260 12.225 5.007 3.667 1.00 97.98 C \\\\nATOM 2072 C PHE A 260 12.692 3.537 3.722 1.00 97.98 C \\\\nATOM 2073 CB PHE A 260 11.377 5.441 4.874 1.00 97.98 C \\\\nATOM 2074 O PHE A 260 12.752 2.855 2.700 1.00 97.98 O \\\\nATOM 2075 CG PHE A 260 10.859 6.873 4.828 1.00 97.98 C \\\\nATOM 2076 CD1 PHE A 260 11.765 7.951 4.833 1.00 97.98 C \\\\nATOM 2077 CD2 PHE A 260 9.476 7.137 4.793 1.00 97.98 C \\\\nATOM 2078 CE1 PHE A 260 11.293 9.276 4.802 1.00 97.98 C \\\\nATOM 2079 CE2 PHE A 260 9.002 8.460 4.769 1.00 97.98 C \\\\nATOM 2080 CZ PHE A 260 9.911 9.533 4.771 1.00 97.98 C \\\\nATOM 2081 N THR A 261 13.114 3.057 4.898 1.00 97.45 N \\\\nATOM 2082 CA THR A 261 13.944 1.843 5.042 1.00 97.45 C \\\\nATOM 2083 C THR A 261 13.457 0.865 6.124 1.00 97.45 C \\\\nATOM 2084 CB THR A 261 15.413 2.228 5.303 1.00 97.45 C \\\\nATOM 2085 O THR A 261 14.274 0.237 6.791 1.00 97.45 O \\\\nATOM 2086 CG2 THR A 261 16.016 3.142 4.236 1.00 97.45 C \\\\nATOM 2087 OG1 THR A 261 15.497 2.905 6.536 1.00 97.45 O \\\\nATOM 2088 N ASP A 262 12.148 0.768 6.359 1.00 95.17 N \\\\nATOM 2089 CA ASP A 262 11.557 -0.171 7.330 1.00 95.17 C \\\\nATOM 2090 C ASP A 262 11.226 -1.508 6.631 1.00 95.17 C \\\\nATOM 2091 CB ASP A 262 10.329 0.514 7.949 1.00 95.17 C \\\\nATOM 2092 O ASP A 262 10.349 -1.517 5.765 1.00 95.17 O \\\\nATOM 2093 CG ASP A 262 9.506 -0.309 8.941 1.00 95.17 C \\\\nATOM 2094 OD1 ASP A 262 9.875 -1.471 9.213 1.00 95.17 O \\\\nATOM 2095 OD2 ASP A 262 8.501 0.287 9.413 1.00 95.17 O \\\\nATOM 2096 N PRO A 263 11.930 -2.617 6.940 1.00 92.14 N \\\\nATOM 2097 CA PRO A 263 11.783 -3.882 6.221 1.00 92.14 C \\\\nATOM 2098 C PRO A 263 10.658 -4.780 6.757 1.00 92.14 C \\\\nATOM 2099 CB PRO A 263 13.144 -4.569 6.390 1.00 92.14 C \\\\nATOM 2100 O PRO A 263 10.397 -5.820 6.161 1.00 92.14 O \\\\nATOM 2101 CG PRO A 263 13.546 -4.156 7.805 1.00 92.14 C \\\\nATOM 2102 CD PRO A 263 13.025 -2.721 7.898 1.00 92.14 C \\\\nATOM 2103 N SER A 264 10.043 -4.456 7.901 1.00 89.29 N \\\\nATOM 2104 CA SER A 264 9.228 -5.412 8.675 1.00 89.29 C \\\\nATOM 2105 C SER A 264 7.748 -5.047 8.797 1.00 89.29 C \\\\nATOM 2106 CB SER A 264 9.852 -5.611 10.058 1.00 89.29 C \\\\nATOM 2107 O SER A 264 6.975 -5.786 9.409 1.00 89.29 O \\\\nATOM 2108 OG SER A 264 9.904 -4.393 10.775 1.00 89.29 O \\\\nATOM 2109 N ASN A 265 7.334 -3.917 8.228 1.00 88.56 N \\\\nATOM 2110 CA ASN A 265 5.992 -3.379 8.391 1.00 88.56 C \\\\nATOM 2111 C ASN A 265 5.062 -3.788 7.234 1.00 88.56 C \\\\nATOM 2112 CB ASN A 265 6.154 -1.869 8.581 1.00 88.56 C \\\\nATOM 2113 O ASN A 265 5.209 -3.325 6.106 1.00 88.56 O \\\\nATOM 2114 CG ASN A 265 4.866 -1.162 8.931 1.00 88.56 C \\\\nATOM 2115 ND2 ASN A 265 4.961 -0.102 9.695 1.00 88.56 N \\\\nATOM 2116 OD1 ASN A 265 3.773 -1.539 8.554 1.00 88.56 O \\\\nATOM 2117 N SER A 266 4.054 -4.613 7.527 1.00 89.15 N \\\\nATOM 2118 CA SER A 266 3.077 -5.123 6.550 1.00 89.15 C \\\\nATOM 2119 C SER A 266 2.102 -4.074 5.990 1.00 89.15 C \\\\nATOM 2120 CB SER A 266 2.299 -6.287 7.168 1.00 89.15 C \\\\nATOM 2121 O SER A 266 1.358 -4.377 5.060 1.00 89.15 O \\\\nATOM 2122 OG SER A 266 1.744 -5.908 8.415 1.00 89.15 O \\\\nATOM 2123 N GLU A 267 2.116 -2.839 6.498 1.00 92.42 N \\\\nATOM 2124 CA GLU A 267 1.410 -1.688 5.916 1.00 92.42 C \\\\nATOM 2125 C GLU A 267 2.337 -0.796 5.064 1.00 92.42 C \\\\nATOM 2126 CB GLU A 267 0.740 -0.852 7.025 1.00 92.42 C \\\\nATOM 2127 O GLU A 267 1.879 0.211 4.517 1.00 92.42 O \\\\nATOM 2128 CG GLU A 267 -0.372 -1.588 7.791 1.00 92.42 C \\\\nATOM 2129 CD GLU A 267 -0.968 -0.749 8.942 1.00 92.42 C \\\\nATOM 2130 OE1 GLU A 267 -1.641 -1.347 9.812 1.00 92.42 O \\\\nATOM 2131 OE2 GLU A 267 -0.756 0.490 8.978 1.00 92.42 O \\\\nATOM 2132 N ARG A 268 3.642 -1.106 4.951 1.00 96.71 N \\\\nATOM 2133 CA ARG A 268 4.633 -0.235 4.295 1.00 96.71 C \\\\nATOM 2134 C ARG A 268 5.581 -0.984 3.360 1.00 96.71 C \\\\nATOM 2135 CB ARG A 268 5.451 0.535 5.336 1.00 96.71 C \\\\nATOM 2136 O ARG A 268 6.459 -1.720 3.799 1.00 96.71 O \\\\nATOM 2137 CG ARG A 268 4.598 1.470 6.205 1.00 96.71 C \\\\nATOM 2138 CD ARG A 268 5.471 2.197 7.229 1.00 96.71 C \\\\nATOM 2139 NE ARG A 268 6.461 3.067 6.578 1.00 96.71 N \\\\nATOM 2140 NH1 ARG A 268 8.178 2.875 8.116 1.00 96.71 N \\\\nATOM 2141 NH2 ARG A 268 8.428 4.071 6.252 1.00 96.71 N \\\\nATOM 2142 CZ ARG A 268 7.677 3.330 7.000 1.00 96.71 C \\\\nATOM 2143 N PHE A 269 5.496 -0.685 2.067 1.00 97.68 N \\\\nATOM 2144 CA PHE A 269 6.505 -1.092 1.095 1.00 97.68 C \\\\nATOM 2145 C PHE A 269 7.594 -0.013 0.995 1.00 97.68 C \\\\nATOM 2146 CB PHE A 269 5.841 -1.419 -0.246 1.00 97.68 C \\\\nATOM 2147 O PHE A 269 7.465 0.977 0.272 1.00 97.68 O \\\\nATOM 2148 CG PHE A 269 6.732 -2.035 -1.317 1.00 97.68 C \\\\nATOM 2149 CD1 PHE A 269 6.290 -2.019 -2.654 1.00 97.68 C \\\\nATOM 2150 CD2 PHE A 269 7.951 -2.678 -1.003 1.00 97.68 C \\\\nATOM 2151 CE1 PHE A 269 7.051 -2.635 -3.663 1.00 97.68 C \\\\nATOM 2152 CE2 PHE A 269 8.709 -3.292 -2.014 1.00 97.68 C \\\\nATOM 2153 CZ PHE A 269 8.260 -3.274 -3.343 1.00 97.68 C \\\\nATOM 2154 N CYS A 270 8.660 -0.192 1.772 1.00 97.96 N \\\\nATOM 2155 CA CYS A 270 9.772 0.749 1.880 1.00 97.96 C \\\\nATOM 2156 C CYS A 270 10.801 0.547 0.756 1.00 97.96 C \\\\nATOM 2157 CB CYS A 270 10.393 0.560 3.264 1.00 97.96 C \\\\nATOM 2158 O CYS A 270 11.706 -0.278 0.855 1.00 97.96 O \\\\nATOM 2159 SG CYS A 270 9.279 1.227 4.523 1.00 97.96 S \\\\nATOM 2160 N LEU A 271 10.700 1.336 -0.313 1.00 98.37 N \\\\nATOM 2161 CA LEU A 271 11.570 1.252 -1.490 1.00 98.37 C \\\\nATOM 2162 C LEU A 271 13.017 1.677 -1.204 1.00 98.37 C \\\\nATOM 2163 CB LEU A 271 10.985 2.129 -2.613 1.00 98.37 C \\\\nATOM 2164 O LEU A 271 13.931 1.282 -1.934 1.00 98.37 O \\\\nATOM 2165 CG LEU A 271 9.530 1.812 -3.013 1.00 98.37 C \\\\nATOM 2166 CD1 LEU A 271 9.126 2.737 -4.161 1.00 98.37 C \\\\nATOM 2167 CD2 LEU A 271 9.361 0.360 -3.452 1.00 98.37 C \\\\nATOM 2168 N GLY A 272 13.246 2.484 -0.163 1.00 97.79 N \\\\nATOM 2169 CA GLY A 272 14.545 3.069 0.179 1.00 97.79 C \\\\nATOM 2170 C GLY A 272 15.617 2.040 0.545 1.00 97.79 C \\\\nATOM 2171 O GLY A 272 16.781 2.254 0.210 1.00 97.79 O \\\\nATOM 2172 N LEU A 273 15.226 0.906 1.141 1.00 96.65 N \\\\nATOM 2173 CA LEU A 273 16.139 -0.196 1.493 1.00 96.65 C \\\\nATOM 2174 C LEU A 273 16.521 -1.096 0.307 1.00 96.65 C \\\\nATOM 2175 CB LEU A 273 15.547 -1.007 2.665 1.00 96.65 C \\\\nATOM 2176 O LEU A 273 17.466 -1.872 0.412 1.00 96.65 O \\\\nATOM 2177 CG LEU A 273 14.300 -1.851 2.311 1.00 96.65 C \\\\nATOM 2178 CD1 LEU A 273 14.642 -3.321 2.064 1.00 96.65 C \\\\nATOM 2179 CD2 LEU A 273 13.283 -1.793 3.449 1.00 96.65 C \\\\nATOM 2180 N LEU A 274 15.799 -1.014 -0.815 1.00 97.53 N \\\\nATOM 2181 CA LEU A 274 16.035 -1.883 -1.966 1.00 97.53 C \\\\nATOM 2182 C LEU A 274 17.331 -1.493 -2.693 1.00 97.53 C \\\\nATOM 2183 CB LEU A 274 14.819 -1.875 -2.911 1.00 97.53 C \\\\nATOM 2184 O LEU A 274 17.503 -0.348 -3.127 1.00 97.53 O \\\\nATOM 2185 CG LEU A 274 13.475 -2.263 -2.261 1.00 97.53 C \\\\nATOM 2186 CD1 LEU A 274 12.360 -2.159 -3.298 1.00 97.53 C \\\\nATOM 2187 CD2 LEU A 274 13.486 -3.689 -1.708 1.00 97.53 C \\\\nATOM 2188 N SER A 275 18.231 -2.457 -2.866 1.00 97.29 N \\\\nATOM 2189 CA SER A 275 19.495 -2.297 -3.593 1.00 97.29 C \\\\nATOM 2190 C SER A 275 19.337 -2.595 -5.084 1.00 97.29 C \\\\nATOM 2191 CB SER A 275 20.570 -3.202 -2.989 1.00 97.29 C \\\\nATOM 2192 O SER A 275 18.613 -3.508 -5.468 1.00 97.29 O \\\\nATOM 2193 OG SER A 275 20.889 -2.729 -1.698 1.00 97.29 O \\\\nATOM 2194 N ASN A 276 20.062 -1.854 -5.922 1.00 97.60 N \\\\nATOM 2195 CA ASN A 276 20.222 -2.133 -7.348 1.00 97.60 C \\\\nATOM 2196 C ASN A 276 21.642 -1.728 -7.766 1.00 97.60 C \\\\nATOM 2197 CB ASN A 276 19.150 -1.372 -8.147 1.00 97.60 C \\\\nATOM 2198 O ASN A 276 22.036 -0.583 -7.550 1.00 97.60 O \\\\nATOM 2199 CG ASN A 276 19.281 -1.562 -9.649 1.00 97.60 C \\\\nATOM 2200 ND2 ASN A 276 18.599 -0.758 -10.423 1.00 97.60 N \\\\nATOM 2201 OD1 ASN A 276 20.009 -2.418 -10.132 1.00 97.60 O \\\\nATOM 2202 N VAL A 277 22.401 -2.660 -8.347 1.00 97.53 N \\\\nATOM 2203 CA VAL A 277 23.790 -2.432 -8.788 1.00 97.53 C \\\\nATOM 2204 C VAL A 277 23.883 -1.607 -10.075 1.00 97.53 C \\\\nATOM 2205 CB VAL A 277 24.560 -3.758 -8.942 1.00 97.53 C \\\\nATOM 2206 O VAL A 277 24.888 -0.944 -10.296 1.00 97.53 O \\\\nATOM 2207 CG1 VAL A 277 24.703 -4.463 -7.586 1.00 97.53 C \\\\nATOM 2208 CG2 VAL A 277 23.902 -4.734 -9.928 1.00 97.53 C \\\\nATOM 2209 N ASN A 278 22.820 -1.582 -10.886 1.00 97.11 N \\\\nATOM 2210 CA ASN A 278 22.754 -0.822 -12.142 1.00 97.11 C \\\\nATOM 2211 C ASN A 278 22.172 0.592 -11.951 1.00 97.11 C \\\\nATOM 2212 CB ASN A 278 21.926 -1.625 -13.154 1.00 97.11 C \\\\nATOM 2213 O ASN A 278 21.821 1.276 -12.916 1.00 97.11 O \\\\nATOM 2214 CG ASN A 278 22.476 -3.007 -13.444 1.00 97.11 C \\\\nATOM 2215 ND2 ASN A 278 21.611 -3.949 -13.725 1.00 97.11 N \\\\nATOM 2216 OD1 ASN A 278 23.666 -3.263 -13.422 1.00 97.11 O \\\\nATOM 2217 N ARG A 279 21.996 1.027 -10.698 1.00 97.96 N \\\\nATOM 2218 CA ARG A 279 21.340 2.290 -10.366 1.00 97.96 C \\\\nATOM 2219 C ARG A 279 22.193 3.478 -10.809 1.00 97.96 C \\\\nATOM 2220 CB ARG A 279 21.060 2.312 -8.863 1.00 97.96 C \\\\nATOM 2221 O ARG A 279 23.320 3.644 -10.360 1.00 97.96 O \\\\nATOM 2222 CG ARG A 279 20.244 3.545 -8.475 1.00 97.96 C \\\\nATOM 2223 CD ARG A 279 19.859 3.495 -6.999 1.00 97.96 C \\\\nATOM 2224 NE ARG A 279 18.879 2.424 -6.746 1.00 97.96 N \\\\nATOM 2225 NH1 ARG A 279 19.536 1.773 -4.627 1.00 97.96 N \\\\nATOM 2226 NH2 ARG A 279 17.786 0.836 -5.597 1.00 97.96 N \\\\nATOM 2227 CZ ARG A 279 18.752 1.686 -5.665 1.00 97.96 C \\\\nATOM 2228 N ASN A 280 21.625 4.343 -11.646 1.00 98.01 N \\\\nATOM 2229 CA ASN A 280 22.284 5.575 -12.082 1.00 98.01 C \\\\nATOM 2230 C ASN A 280 21.891 6.792 -11.219 1.00 98.01 C \\\\nATOM 2231 CB ASN A 280 22.066 5.759 -13.597 1.00 98.01 C \\\\nATOM 2232 O ASN A 280 20.905 6.771 -10.476 1.00 98.01 O \\\\nATOM 2233 CG ASN A 280 20.659 6.171 -13.997 1.00 98.01 C \\\\nATOM 2234 ND2 ASN A 280 20.158 5.652 -15.090 1.00 98.01 N \\\\nATOM 2235 OD1 ASN A 280 20.010 6.991 -13.367 1.00 98.01 O \\\\nATOM 2236 N ALA A 281 22.632 7.894 -11.368 1.00 98.22 N \\\\nATOM 2237 CA ALA A 281 22.433 9.122 -10.594 1.00 98.22 C \\\\nATOM 2238 C ALA A 281 21.018 9.732 -10.717 1.00 98.22 C \\\\nATOM 2239 CB ALA A 281 23.501 10.127 -11.044 1.00 98.22 C \\\\nATOM 2240 O ALA A 281 20.518 10.328 -9.762 1.00 98.22 O \\\\nATOM 2241 N ALA A 282 20.339 9.570 -11.860 1.00 97.51 N \\\\nATOM 2242 CA ALA A 282 18.974 10.067 -12.047 1.00 97.51 C \\\\nATOM 2243 C ALA A 282 17.950 9.249 -11.239 1.00 97.51 C \\\\nATOM 2244 CB ALA A 282 18.643 10.075 -13.544 1.00 97.51 C \\\\nATOM 2245 O ALA A 282 16.999 9.815 -10.689 1.00 97.51 O \\\\nATOM 2246 N VAL A 283 18.165 7.934 -11.122 1.00 98.47 N \\\\nATOM 2247 CA VAL A 283 17.389 7.047 -10.245 1.00 98.47 C \\\\nATOM 2248 C VAL A 283 17.664 7.375 -8.778 1.00 98.47 C \\\\nATOM 2249 CB VAL A 283 17.676 5.565 -10.555 1.00 98.47 C \\\\nATOM 2250 O VAL A 283 16.717 7.591 -8.027 1.00 98.47 O \\\\nATOM 2251 CG1 VAL A 283 16.889 4.649 -9.617 1.00 98.47 C \\\\nATOM 2252 CG2 VAL A 283 17.304 5.177 -11.993 1.00 98.47 C \\\\nATOM 2253 N GLU A 284 18.928 7.516 -8.364 1.00 98.10 N \\\\nATOM 2254 CA GLU A 284 19.264 7.908 -6.985 1.00 98.10 C \\\\nATOM 2255 C GLU A 284 18.616 9.230 -6.565 1.00 98.10 C \\\\nATOM 2256 CB GLU A 284 20.767 8.100 -6.802 1.00 98.10 C \\\\nATOM 2257 O GLU A 284 18.015 9.320 -5.492 1.00 98.10 O \\\\nATOM 2258 CG GLU A 284 21.591 6.819 -6.912 1.00 98.10 C \\\\nATOM 2259 CD GLU A 284 23.012 7.033 -6.376 1.00 98.10 C \\\\nATOM 2260 OE1 GLU A 284 23.693 6.005 -6.206 1.00 98.10 O \\\\nATOM 2261 OE2 GLU A 284 23.355 8.200 -6.052 1.00 98.10 O \\\\nATOM 2262 N LEU A 285 18.712 10.256 -7.416 1.00 97.88 N \\\\nATOM 2263 CA LEU A 285 18.103 11.557 -7.160 1.00 97.88 C \\\\nATOM 2264 C LEU A 285 16.577 11.448 -7.064 1.00 97.88 C \\\\nATOM 2265 CB LEU A 285 18.540 12.528 -8.271 1.00 97.88 C \\\\nATOM 2266 O LEU A 285 15.972 12.091 -6.209 1.00 97.88 O \\\\nATOM 2267 CG LEU A 285 18.038 13.971 -8.080 1.00 97.88 C \\\\nATOM 2268 CD1 LEU A 285 18.614 14.620 -6.819 1.00 97.88 C \\\\nATOM 2269 CD2 LEU A 285 18.441 14.815 -9.287 1.00 97.88 C \\\\nATOM 2270 N THR A 286 15.953 10.614 -7.899 1.00 98.50 N \\\\nATOM 2271 CA THR A 286 14.501 10.386 -7.877 1.00 98.50 C \\\\nATOM 2272 C THR A 286 14.064 9.674 -6.596 1.00 98.50 C \\\\nATOM 2273 CB THR A 286 14.054 9.625 -9.133 1.00 98.50 C \\\\nATOM 2274 O THR A 286 13.122 10.129 -5.949 1.00 98.50 O \\\\nATOM 2275 CG2 THR A 286 12.547 9.397 -9.178 1.00 98.50 C \\\\nATOM 2276 OG1 THR A 286 14.390 10.398 -10.269 1.00 98.50 O \\\\nATOM 2277 N ARG A 287 14.794 8.638 -6.154 1.00 98.55 N \\\\nATOM 2278 CA ARG A 287 14.523 7.904 -4.901 1.00 98.55 C \\\\nATOM 2279 C ARG A 287 14.482 8.822 -3.678 1.00 98.55 C \\\\nATOM 2280 CB ARG A 287 15.564 6.790 -4.704 1.00 98.55 C \\\\nATOM 2281 O ARG A 287 13.576 8.694 -2.859 1.00 98.55 O \\\\nATOM 2282 CG ARG A 287 15.359 5.631 -5.690 1.00 98.55 C \\\\nATOM 2283 CD ARG A 287 16.531 4.646 -5.688 1.00 98.55 C \\\\nATOM 2284 NE ARG A 287 16.726 3.989 -4.382 1.00 98.55 N \\\\nATOM 2285 NH1 ARG A 287 15.047 2.408 -4.548 1.00 98.55 N \\\\nATOM 2286 NH2 ARG A 287 16.237 2.559 -2.695 1.00 98.55 N \\\\nATOM 2287 CZ ARG A 287 16.004 2.997 -3.893 1.00 98.55 C \\\\nATOM 2288 N ARG A 288 15.396 9.799 -3.592 1.00 98.14 N \\\\nATOM 2289 CA ARG A 288 15.428 10.806 -2.505 1.00 98.14 C \\\\nATOM 2290 C ARG A 288 14.143 11.644 -2.420 1.00 98.14 C \\\\nATOM 2291 CB ARG A 288 16.650 11.731 -2.667 1.00 98.14 C \\\\nATOM 2292 O ARG A 288 13.778 12.070 -1.332 1.00 98.14 O \\\\nATOM 2293 CG ARG A 288 17.993 11.000 -2.498 1.00 98.14 C \\\\nATOM 2294 CD ARG A 288 19.181 11.901 -2.874 1.00 98.14 C \\\\nATOM 2295 NE ARG A 288 20.398 11.107 -3.150 1.00 98.14 N \\\\nATOM 2296 NH1 ARG A 288 21.675 12.765 -4.097 1.00 98.14 N \\\\nATOM 2297 NH2 ARG A 288 22.412 10.662 -4.146 1.00 98.14 N \\\\nATOM 2298 CZ ARG A 288 21.488 11.511 -3.787 1.00 98.14 C \\\\nATOM 2299 N HIS A 289 13.449 11.845 -3.541 1.00 98.35 N \\\\nATOM 2300 CA HIS A 289 12.217 12.635 -3.628 1.00 98.35 C \\\\nATOM 2301 C HIS A 289 10.932 11.800 -3.487 1.00 98.35 C \\\\nATOM 2302 CB HIS A 289 12.228 13.443 -4.933 1.00 98.35 C \\\\nATOM 2303 O HIS A 289 9.845 12.371 -3.441 1.00 98.35 O \\\\nATOM 2304 CG HIS A 289 13.279 14.519 -4.971 1.00 98.35 C \\\\nATOM 2305 CD2 HIS A 289 13.114 15.837 -4.644 1.00 98.35 C \\\\nATOM 2306 ND1 HIS A 289 14.587 14.359 -5.363 1.00 98.35 N \\\\nATOM 2307 CE1 HIS A 289 15.198 15.549 -5.271 1.00 98.35 C \\\\nATOM 2308 NE2 HIS A 289 14.339 16.483 -4.845 1.00 98.35 N \\\\nATOM 2309 N ILE A 290 11.017 10.466 -3.369 1.00 98.63 N \\\\nATOM 2310 CA ILE A 290 9.841 9.639 -3.050 1.00 98.63 C \\\\nATOM 2311 C ILE A 290 9.306 10.043 -1.671 1.00 98.63 C \\\\nATOM 2312 CB ILE A 290 10.157 8.125 -3.141 1.00 98.63 C \\\\nATOM 2313 O ILE A 290 8.115 10.314 -1.533 1.00 98.63 O \\\\nATOM 2314 CG1 ILE A 290 10.603 7.762 -4.577 1.00 98.63 C \\\\nATOM 2315 CG2 ILE A 290 8.930 7.285 -2.733 1.00 98.63 C \\\\nATOM 2316 CD1 ILE A 290 11.006 6.296 -4.777 1.00 98.63 C \\\\nATOM 2317 N GLY A 291 10.179 10.159 -0.662 1.00 97.93 N \\\\nATOM 2318 CA GLY A 291 9.796 10.581 0.688 1.00 97.93 C \\\\nATOM 2319 C GLY A 291 8.689 9.692 1.258 1.00 97.93 C \\\\nATOM 2320 O GLY A 291 8.837 8.476 1.311 1.00 97.93 O \\\\nATOM 2321 N ARG A 292 7.549 10.284 1.631 1.00 97.98 N \\\\nATOM 2322 CA ARG A 292 6.356 9.552 2.107 1.00 97.98 C \\\\nATOM 2323 C ARG A 292 5.579 8.813 1.001 1.00 97.98 C \\\\nATOM 2324 CB ARG A 292 5.429 10.523 2.843 1.00 97.98 C \\\\nATOM 2325 O ARG A 292 4.648 8.084 1.323 1.00 97.98 O \\\\nATOM 2326 CG ARG A 292 6.043 11.155 4.102 1.00 97.98 C \\\\nATOM 2327 CD ARG A 292 5.155 12.291 4.625 1.00 97.98 C \\\\nATOM 2328 NE ARG A 292 3.816 11.807 5.025 1.00 97.98 N \\\\nATOM 2329 NH1 ARG A 292 2.560 13.478 4.052 1.00 97.98 N \\\\nATOM 2330 NH2 ARG A 292 1.550 11.850 5.190 1.00 97.98 N \\\\nATOM 2331 CZ ARG A 292 2.657 12.386 4.757 1.00 97.98 C \\\\nATOM 2332 N GLY A 293 5.940 9.013 -0.267 1.00 98.48 N \\\\nATOM 2333 CA GLY A 293 5.458 8.255 -1.421 1.00 98.48 C \\\\nATOM 2334 C GLY A 293 3.948 8.325 -1.660 1.00 98.48 C \\\\nATOM 2335 O GLY A 293 3.371 9.413 -1.711 1.00 98.48 O \\\\nATOM 2336 N VAL A 294 3.316 7.167 -1.851 1.00 98.76 N \\\\nATOM 2337 CA VAL A 294 1.883 7.027 -2.148 1.00 98.76 C \\\\nATOM 2338 C VAL A 294 1.199 6.162 -1.095 1.00 98.76 C \\\\nATOM 2339 CB VAL A 294 1.649 6.501 -3.583 1.00 98.76 C \\\\nATOM 2340 O VAL A 294 1.681 5.080 -0.764 1.00 98.76 O \\\\nATOM 2341 CG1 VAL A 294 2.258 5.122 -3.865 1.00 98.76 C \\\\nATOM 2342 CG2 VAL A 294 0.160 6.438 -3.941 1.00 98.76 C \\\\nATOM 2343 N ARG A 295 0.049 6.616 -0.588 1.00 98.09 N \\\\nATOM 2344 CA ARG A 295 -0.880 5.762 0.159 1.00 98.09 C \\\\nATOM 2345 C ARG A 295 -1.883 5.153 -0.811 1.00 98.09 C \\\\nATOM 2346 CB ARG A 295 -1.528 6.533 1.317 1.00 98.09 C \\\\nATOM 2347 O ARG A 295 -2.517 5.875 -1.576 1.00 98.09 O \\\\nATOM 2348 CG ARG A 295 -2.630 5.709 1.999 1.00 98.09 C \\\\nATOM 2349 CD ARG A 295 -3.123 6.304 3.319 1.00 98.09 C \\\\nATOM 2350 NE ARG A 295 -3.835 7.594 3.177 1.00 98.09 N \\\\nATOM 2351 NH1 ARG A 295 -4.351 7.823 5.400 1.00 98.09 N \\\\nATOM 2352 NH2 ARG A 295 -4.968 9.401 4.026 1.00 98.09 N \\\\nATOM 2353 CZ ARG A 295 -4.365 8.267 4.180 1.00 98.09 C \\\\nATOM 2354 N LEU A 296 -2.036 3.839 -0.738 1.00 98.08 N \\\\nATOM 2355 CA LEU A 296 -3.010 3.062 -1.490 1.00 98.08 C \\\\nATOM 2356 C LEU A 296 -4.043 2.516 -0.509 1.00 98.08 C \\\\nATOM 2357 CB LEU A 296 -2.294 1.924 -2.231 1.00 98.08 C \\\\nATOM 2358 O LEU A 296 -3.667 2.012 0.551 1.00 98.08 O \\\\nATOM 2359 CG LEU A 296 -1.248 2.381 -3.261 1.00 98.08 C \\\\nATOM 2360 CD1 LEU A 296 -0.411 1.178 -3.685 1.00 98.08 C \\\\nATOM 2361 CD2 LEU A 296 -1.904 3.007 -4.492 1.00 98.08 C \\\\nATOM 2362 N TYR A 297 -5.329 2.623 -0.832 1.00 95.51 N \\\\nATOM 2363 CA TYR A 297 -6.385 2.059 0.007 1.00 95.51 C \\\\nATOM 2364 C TYR A 297 -7.529 1.468 -0.814 1.00 95.51 C \\\\nATOM 2365 CB TYR A 297 -6.864 3.077 1.057 1.00 95.51 C \\\\nATOM 2366 O TYR A 297 -7.959 2.065 -1.801 1.00 95.51 O \\\\nATOM 2367 CG TYR A 297 -7.340 4.429 0.545 1.00 95.51 C \\\\nATOM 2368 CD1 TYR A 297 -6.414 5.466 0.324 1.00 95.51 C \\\\nATOM 2369 CD2 TYR A 297 -8.708 4.666 0.320 1.00 95.51 C \\\\nATOM 2370 CE1 TYR A 297 -6.849 6.736 -0.100 1.00 95.51 C \\\\nATOM 2371 CE2 TYR A 297 -9.157 5.940 -0.083 1.00 95.51 C \\\\nATOM 2372 OH TYR A 297 -8.632 8.188 -0.768 1.00 95.51 O \\\\nATOM 2373 CZ TYR A 297 -8.223 6.975 -0.311 1.00 95.51 C \\\\nATOM 2374 N TYR A 298 -8.002 0.301 -0.375 1.00 94.74 N \\\\nATOM 2375 CA TYR A 298 -9.119 -0.454 -0.933 1.00 94.74 C \\\\nATOM 2376 C TYR A 298 -10.305 -0.400 0.031 1.00 94.74 C \\\\nATOM 2377 CB TYR A 298 -8.687 -1.901 -1.202 1.00 94.74 C \\\\nATOM 2378 O TYR A 298 -10.216 -0.871 1.165 1.00 94.74 O \\\\nATOM 2379 CG TYR A 298 -9.816 -2.794 -1.687 1.00 94.74 C \\\\nATOM 2380 CD1 TYR A 298 -10.159 -3.964 -0.979 1.00 94.74 C \\\\nATOM 2381 CD2 TYR A 298 -10.533 -2.448 -2.849 1.00 94.74 C \\\\nATOM 2382 CE1 TYR A 298 -11.210 -4.787 -1.436 1.00 94.74 C \\\\nATOM 2383 CE2 TYR A 298 -11.572 -3.276 -3.314 1.00 94.74 C \\\\nATOM 2384 OH TYR A 298 -12.949 -5.212 -3.055 1.00 94.74 O \\\\nATOM 2385 CZ TYR A 298 -11.919 -4.446 -2.607 1.00 94.74 C \\\\nATOM 2386 N ILE A 299 -11.394 0.244 -0.388 1.00 91.25 N \\\\nATOM 2387 CA ILE A 299 -12.558 0.535 0.455 1.00 91.25 C \\\\nATOM 2388 C ILE A 299 -13.815 0.469 -0.405 1.00 91.25 C \\\\nATOM 2389 CB ILE A 299 -12.423 1.927 1.118 1.00 91.25 C \\\\nATOM 2390 O ILE A 299 -13.893 1.129 -1.436 1.00 91.25 O \\\\nATOM 2391 CG1 ILE A 299 -11.142 1.993 1.981 1.00 91.25 C \\\\nATOM 2392 CG2 ILE A 299 -13.670 2.255 1.966 1.00 91.25 C \\\\nATOM 2393 CD1 ILE A 299 -10.920 3.332 2.662 1.00 91.25 C \\\\nATOM 2394 N GLY A 300 -14.817 -0.298 0.027 1.00 87.74 N \\\\nATOM 2395 CA GLY A 300 -16.122 -0.324 -0.635 1.00 87.74 C \\\\nATOM 2396 C GLY A 300 -16.095 -0.843 -2.079 1.00 87.74 C \\\\nATOM 2397 O GLY A 300 -16.918 -0.420 -2.883 1.00 87.74 O \\\\nATOM 2398 N GLY A 301 -15.134 -1.703 -2.439 1.00 92.50 N \\\\nATOM 2399 CA GLY A 301 -14.932 -2.138 -3.827 1.00 92.50 C \\\\nATOM 2400 C GLY A 301 -14.189 -1.123 -4.709 1.00 92.50 C \\\\nATOM 2401 O GLY A 301 -14.130 -1.302 -5.923 1.00 92.50 O \\\\nATOM 2402 N GLU A 302 -13.621 -0.061 -4.133 1.00 96.35 N \\\\nATOM 2403 CA GLU A 302 -12.888 0.985 -4.850 1.00 96.35 C \\\\nATOM 2404 C GLU A 302 -11.437 1.070 -4.369 1.00 96.35 C \\\\nATOM 2405 CB GLU A 302 -13.577 2.348 -4.682 1.00 96.35 C \\\\nATOM 2406 O GLU A 302 -11.167 0.962 -3.172 1.00 96.35 O \\\\nATOM 2407 CG GLU A 302 -15.088 2.312 -4.939 1.00 96.35 C \\\\nATOM 2408 CD GLU A 302 -15.652 3.709 -5.205 1.00 96.35 C \\\\nATOM 2409 OE1 GLU A 302 -16.276 3.889 -6.275 1.00 96.35 O \\\\nATOM 2410 OE2 GLU A 302 -15.407 4.677 -4.447 1.00 96.35 O \\\\nATOM 2411 N VAL A 303 -10.497 1.306 -5.288 1.00 97.65 N \\\\nATOM 2412 CA VAL A 303 -9.086 1.555 -4.958 1.00 97.65 C \\\\nATOM 2413 C VAL A 303 -8.758 3.017 -5.223 1.00 97.65 C \\\\nATOM 2414 CB VAL A 303 -8.101 0.632 -5.703 1.00 97.65 C \\\\nATOM 2415 O VAL A 303 -9.085 3.566 -6.279 1.00 97.65 O \\\\nATOM 2416 CG1 VAL A 303 -6.685 0.759 -5.122 1.00 97.65 C \\\\nATOM 2417 CG2 VAL A 303 -8.473 -0.853 -5.616 1.00 97.65 C \\\\nATOM 2418 N PHE A 304 -8.050 3.639 -4.287 1.00 98.07 N \\\\nATOM 2419 CA PHE A 304 -7.582 5.017 -4.387 1.00 98.07 C \\\\nATOM 2420 C PHE A 304 -6.065 5.109 -4.219 1.00 98.07 C \\\\nATOM 2421 CB PHE A 304 -8.259 5.861 -3.314 1.00 98.07 C \\\\nATOM 2422 O PHE A 304 -5.465 4.343 -3.462 1.00 98.07 O \\\\nATOM 2423 CG PHE A 304 -9.768 5.994 -3.396 1.00 98.07 C \\\\nATOM 2424 CD1 PHE A 304 -10.346 7.178 -3.895 1.00 98.07 C \\\\nATOM 2425 CD2 PHE A 304 -10.598 4.970 -2.898 1.00 98.07 C \\\\nATOM 2426 CE1 PHE A 304 -11.745 7.331 -3.908 1.00 98.07 C \\\\nATOM 2427 CE2 PHE A 304 -11.993 5.130 -2.902 1.00 98.07 C \\\\nATOM 2428 CZ PHE A 304 -12.568 6.303 -3.416 1.00 98.07 C \\\\nATOM 2429 N ALA A 305 -5.465 6.102 -4.876 1.00 98.57 N \\\\nATOM 2430 CA ALA A 305 -4.087 6.528 -4.654 1.00 98.57 C \\\\nATOM 2431 C ALA A 305 -4.061 7.952 -4.097 1.00 98.57 C \\\\nATOM 2432 CB ALA A 305 -3.307 6.433 -5.966 1.00 98.57 C \\\\nATOM 2433 O ALA A 305 -4.728 8.836 -4.629 1.00 98.57 O \\\\nATOM 2434 N GLU A 306 -3.273 8.188 -3.053 1.00 98.38 N \\\\nATOM 2435 CA GLU A 306 -3.106 9.485 -2.395 1.00 98.38 C \\\\nATOM 2436 C GLU A 306 -1.620 9.847 -2.324 1.00 98.38 C \\\\nATOM 2437 CB GLU A 306 -3.768 9.411 -1.014 1.00 98.38 C \\\\nATOM 2438 O GLU A 306 -0.812 9.109 -1.754 1.00 98.38 O \\\\nATOM 2439 CG GLU A 306 -3.686 10.690 -0.165 1.00 98.38 C \\\\nATOM 2440 CD GLU A 306 -4.307 10.462 1.224 1.00 98.38 C \\\\nATOM 2441 OE1 GLU A 306 -3.891 11.102 2.218 1.00 98.38 O \\\\nATOM 2442 OE2 GLU A 306 -5.160 9.553 1.396 1.00 98.38 O \\\\nATOM 2443 N CYS A 307 -1.250 10.987 -2.907 1.00 98.55 N \\\\nATOM 2444 CA CYS A 307 0.134 11.440 -2.960 1.00 98.55 C \\\\nATOM 2445 C CYS A 307 0.551 12.019 -1.602 1.00 98.55 C \\\\nATOM 2446 CB CYS A 307 0.277 12.448 -4.103 1.00 98.55 C \\\\nATOM 2447 O CYS A 307 0.202 13.148 -1.256 1.00 98.55 O \\\\nATOM 2448 SG CYS A 307 2.033 12.800 -4.388 1.00 98.55 S \\\\nATOM 2449 N LEU A 308 1.309 11.243 -0.824 1.00 98.21 N \\\\nATOM 2450 CA LEU A 308 1.869 11.676 0.458 1.00 98.21 C \\\\nATOM 2451 C LEU A 308 3.240 12.351 0.316 1.00 98.21 C \\\\nATOM 2452 CB LEU A 308 1.971 10.471 1.404 1.00 98.21 C \\\\nATOM 2453 O LEU A 308 3.667 13.040 1.247 1.00 98.21 O \\\\nATOM 2454 CG LEU A 308 0.651 9.781 1.786 1.00 98.21 C \\\\nATOM 2455 CD1 LEU A 308 0.945 8.821 2.942 1.00 98.21 C \\\\nATOM 2456 CD2 LEU A 308 -0.428 10.758 2.256 1.00 98.21 C \\\\nATOM 2457 N SER A 309 3.918 12.113 -0.808 1.00 98.38 N \\\\nATOM 2458 CA SER A 309 5.160 12.764 -1.220 1.00 98.38 C \\\\nATOM 2459 C SER A 309 4.962 14.255 -1.504 1.00 98.38 C \\\\nATOM 2460 CB SER A 309 5.692 12.085 -2.486 1.00 98.38 C \\\\nATOM 2461 O SER A 309 3.910 14.669 -1.993 1.00 98.38 O \\\\nATOM 2462 OG SER A 309 6.949 12.629 -2.837 1.00 98.38 O \\\\nATOM 2463 N ASP A 310 6.018 15.035 -1.266 1.00 98.37 N \\\\nATOM 2464 CA ASP A 310 6.132 16.441 -1.669 1.00 98.37 C \\\\nATOM 2465 C ASP A 310 6.377 16.594 -3.189 1.00 98.37 C \\\\nATOM 2466 CB ASP A 310 7.257 17.105 -0.855 1.00 98.37 C \\\\nATOM 2467 O ASP A 310 6.329 17.696 -3.731 1.00 98.37 O \\\\nATOM 2468 CG ASP A 310 7.108 16.885 0.657 1.00 98.37 C \\\\nATOM 2469 OD1 ASP A 310 6.020 17.183 1.199 1.00 98.37 O \\\\nATOM 2470 OD2 ASP A 310 8.070 16.356 1.258 1.00 98.37 O \\\\nATOM 2471 N SER A 311 6.618 15.485 -3.899 1.00 98.40 N \\\\nATOM 2472 CA SER A 311 6.662 15.398 -5.363 1.00 98.40 C \\\\nATOM 2473 C SER A 311 5.446 14.649 -5.905 1.00 98.40 C \\\\nATOM 2474 CB SER A 311 7.935 14.680 -5.804 1.00 98.40 C \\\\nATOM 2475 O SER A 311 5.000 13.672 -5.314 1.00 98.40 O \\\\nATOM 2476 OG SER A 311 9.054 15.498 -5.541 1.00 98.40 O \\\\nATOM 2477 N ALA A 312 4.929 15.070 -7.062 1.00 98.66 N \\\\nATOM 2478 CA ALA A 312 3.782 14.415 -7.693 1.00 98.66 C \\\\nATOM 2479 C ALA A 312 4.071 12.953 -8.088 1.00 98.66 C \\\\nATOM 2480 CB ALA A 312 3.342 15.240 -8.910 1.00 98.66 C \\\\nATOM 2481 O ALA A 312 5.201 12.598 -8.445 1.00 98.66 O \\\\nATOM 2482 N ILE A 313 3.015 12.141 -8.102 1.00 98.82 N \\\\nATOM 2483 CA ILE A 313 2.999 10.804 -8.707 1.00 98.82 C \\\\nATOM 2484 C ILE A 313 2.170 10.823 -9.996 1.00 98.82 C \\\\nATOM 2485 CB ILE A 313 2.538 9.719 -7.707 1.00 98.82 C \\\\nATOM 2486 O ILE A 313 1.347 11.714 -10.212 1.00 98.82 O \\\\nATOM 2487 CG1 ILE A 313 1.073 9.935 -7.277 1.00 98.82 C \\\\nATOM 2488 CG2 ILE A 313 3.504 9.665 -6.509 1.00 98.82 C \\\\nATOM 2489 CD1 ILE A 313 0.539 8.921 -6.265 1.00 98.82 C \\\\nATOM 2490 N PHE A 314 2.401 9.848 -10.865 1.00 98.73 N \\\\nATOM 2491 CA PHE A 314 1.799 9.763 -12.195 1.00 98.73 C \\\\nATOM 2492 C PHE A 314 1.232 8.361 -12.370 1.00 98.73 C \\\\nATOM 2493 CB PHE A 314 2.873 10.087 -13.242 1.00 98.73 C \\\\nATOM 2494 O PHE A 314 1.959 7.403 -12.131 1.00 98.73 O \\\\nATOM 2495 CG PHE A 314 3.483 11.464 -13.086 1.00 98.73 C \\\\nATOM 2496 CD1 PHE A 314 2.991 12.550 -13.832 1.00 98.73 C \\\\nATOM 2497 CD2 PHE A 314 4.534 11.664 -12.170 1.00 98.73 C \\\\nATOM 2498 CE1 PHE A 314 3.556 13.826 -13.660 1.00 98.73 C \\\\nATOM 2499 CE2 PHE A 314 5.066 12.949 -11.972 1.00 98.73 C \\\\nATOM 2500 CZ PHE A 314 4.588 14.029 -12.729 1.00 98.73 C \\\\nATOM 2501 N VAL A 315 -0.044 8.232 -12.728 1.00 98.59 N \\\\nATOM 2502 CA VAL A 315 -0.794 6.970 -12.686 1.00 98.59 C \\\\nATOM 2503 C VAL A 315 -1.401 6.660 -14.047 1.00 98.59 C \\\\nATOM 2504 CB VAL A 315 -1.905 7.017 -11.616 1.00 98.59 C \\\\nATOM 2505 O VAL A 315 -2.157 7.463 -14.581 1.00 98.59 O \\\\nATOM 2506 CG1 VAL A 315 -2.648 5.676 -11.526 1.00 98.59 C \\\\nATOM 2507 CG2 VAL A 315 -1.334 7.361 -10.232 1.00 98.59 C \\\\nATOM 2508 N GLN A 316 -1.131 5.467 -14.567 1.00 98.50 N \\\\nATOM 2509 CA GLN A 316 -1.849 4.879 -15.694 1.00 98.50 C \\\\nATOM 2510 C GLN A 316 -2.736 3.760 -15.142 1.00 98.50 C \\\\nATOM 2511 CB GLN A 316 -0.823 4.384 -16.721 1.00 98.50 C \\\\nATOM 2512 O GLN A 316 -2.234 2.719 -14.716 1.00 98.50 O \\\\nATOM 2513 CG GLN A 316 -1.429 3.791 -17.999 1.00 98.50 C \\\\nATOM 2514 CD GLN A 316 -0.336 3.221 -18.902 1.00 98.50 C \\\\nATOM 2515 NE2 GLN A 316 -0.040 3.836 -20.027 1.00 98.50 N \\\\nATOM 2516 OE1 GLN A 316 0.309 2.230 -18.589 1.00 98.50 O \\\\nATOM 2517 N SER A 317 -4.049 3.996 -15.117 1.00 98.39 N \\\\nATOM 2518 CA SER A 317 -5.060 2.984 -14.795 1.00 98.39 C \\\\nATOM 2519 C SER A 317 -6.089 2.946 -15.923 1.00 98.39 C \\\\nATOM 2520 CB SER A 317 -5.762 3.277 -13.467 1.00 98.39 C \\\\nATOM 2521 O SER A 317 -6.858 3.903 -16.054 1.00 98.39 O \\\\nATOM 2522 OG SER A 317 -6.874 2.408 -13.353 1.00 98.39 O \\\\nATOM 2523 N PRO A 318 -6.152 1.862 -16.715 1.00 97.77 N \\\\nATOM 2524 CA PRO A 318 -7.133 1.740 -17.789 1.00 97.77 C \\\\nATOM 2525 C PRO A 318 -8.589 1.853 -17.303 1.00 97.77 C \\\\nATOM 2526 CB PRO A 318 -6.821 0.396 -18.446 1.00 97.77 C \\\\nATOM 2527 O PRO A 318 -9.390 2.516 -17.953 1.00 97.77 O \\\\nATOM 2528 CG PRO A 318 -5.322 0.232 -18.214 1.00 97.77 C \\\\nATOM 2529 CD PRO A 318 -5.171 0.786 -16.801 1.00 97.77 C \\\\nATOM 2530 N ASN A 319 -8.918 1.326 -16.113 1.00 97.99 N \\\\nATOM 2531 CA ASN A 319 -10.244 1.493 -15.496 1.00 97.99 C \\\\nATOM 2532 C ASN A 319 -10.566 2.966 -15.183 1.00 97.99 C \\\\nATOM 2533 CB ASN A 319 -10.309 0.611 -14.236 1.00 97.99 C \\\\nATOM 2534 O ASN A 319 -11.661 3.438 -15.478 1.00 97.99 O \\\\nATOM 2535 CG ASN A 319 -11.614 0.775 -13.470 1.00 97.99 C \\\\nATOM 2536 ND2 ASN A 319 -12.663 0.081 -13.837 1.00 97.99 N \\\\nATOM 2537 OD1 ASN A 319 -11.698 1.547 -12.527 1.00 97.99 O \\\\nATOM 2538 N CYS A 320 -9.600 3.715 -14.641 1.00 97.61 N \\\\nATOM 2539 CA CYS A 320 -9.765 5.149 -14.404 1.00 97.61 C \\\\nATOM 2540 C CYS A 320 -9.915 5.926 -15.721 1.00 97.61 C \\\\nATOM 2541 CB CYS A 320 -8.560 5.644 -13.598 1.00 97.61 C \\\\nATOM 2542 O CYS A 320 -10.769 6.803 -15.818 1.00 97.61 O \\\\nATOM 2543 SG CYS A 320 -8.805 7.360 -13.069 1.00 97.61 S \\\\nATOM 2544 N ASN A 321 -9.107 5.597 -16.730 1.00 97.67 N \\\\nATOM 2545 CA ASN A 321 -9.126 6.263 -18.030 1.00 97.67 C \\\\nATOM 2546 C ASN A 321 -10.470 6.049 -18.742 1.00 97.67 C \\\\nATOM 2547 CB ASN A 321 -7.913 5.779 -18.849 1.00 97.67 C \\\\nATOM 2548 O ASN A 321 -11.088 7.022 -19.169 1.00 97.67 O \\\\nATOM 2549 CG ASN A 321 -6.587 6.264 -18.280 1.00 97.67 C \\\\nATOM 2550 ND2 ASN A 321 -5.481 5.659 -18.640 1.00 97.67 N \\\\nATOM 2551 OD1 ASN A 321 -6.511 7.213 -17.517 1.00 97.67 O \\\\nATOM 2552 N GLN A 322 -10.981 4.814 -18.757 1.00 96.68 N \\\\nATOM 2553 CA GLN A 322 -12.291 4.489 -19.322 1.00 96.68 C \\\\nATOM 2554 C GLN A 322 -13.438 5.228 -18.615 1.00 96.68 C \\\\nATOM 2555 CB GLN A 322 -12.479 2.967 -19.285 1.00 96.68 C \\\\nATOM 2556 O GLN A 322 -14.307 5.769 -19.296 1.00 96.68 O \\\\nATOM 2557 CG GLN A 322 -13.796 2.518 -19.940 1.00 96.68 C \\\\nATOM 2558 CD GLN A 322 -13.909 1.001 -20.053 1.00 96.68 C \\\\nATOM 2559 NE2 GLN A 322 -15.063 0.474 -20.393 1.00 96.68 N \\\\nATOM 2560 OE1 GLN A 322 -12.970 0.258 -19.833 1.00 96.68 O \\\\nATOM 2561 N ARG A 323 -13.426 5.330 -17.274 1.00 96.89 N \\\\nATOM 2562 CA ARG A 323 -14.443 6.083 -16.507 1.00 96.89 C \\\\nATOM 2563 C ARG A 323 -14.564 7.543 -16.958 1.00 96.89 C \\\\nATOM 2564 CB ARG A 323 -14.107 6.024 -15.006 1.00 96.89 C \\\\nATOM 2565 O ARG A 323 -15.663 8.090 -16.961 1.00 96.89 O \\\\nATOM 2566 CG ARG A 323 -15.199 6.657 -14.117 1.00 96.89 C \\\\nATOM 2567 CD ARG A 323 -14.716 6.904 -12.685 1.00 96.89 C \\\\nATOM 2568 NE ARG A 323 -14.325 5.643 -12.043 1.00 96.89 N \\\\nATOM 2569 NH1 ARG A 323 -12.182 6.137 -11.428 1.00 96.89 N \\\\nATOM 2570 NH2 ARG A 323 -12.918 4.017 -11.386 1.00 96.89 N \\\\nATOM 2571 CZ ARG A 323 -13.140 5.272 -11.615 1.00 96.89 C \\\\nATOM 2572 N TYR A 324 -13.446 8.175 -17.312 1.00 96.60 N \\\\nATOM 2573 CA TYR A 324 -13.397 9.579 -17.733 1.00 96.60 C \\\\nATOM 2574 C TYR A 324 -13.390 9.773 -19.261 1.00 96.60 C \\\\nATOM 2575 CB TYR A 324 -12.221 10.278 -17.032 1.00 96.60 C \\\\nATOM 2576 O TYR A 324 -13.228 10.900 -19.721 1.00 96.60 O \\\\nATOM 2577 CG TYR A 324 -12.352 10.360 -15.519 1.00 96.60 C \\\\nATOM 2578 CD1 TYR A 324 -13.401 11.106 -14.946 1.00 96.60 C \\\\nATOM 2579 CD2 TYR A 324 -11.424 9.710 -14.684 1.00 96.60 C \\\\nATOM 2580 CE1 TYR A 324 -13.535 11.186 -13.547 1.00 96.60 C \\\\nATOM 2581 CE2 TYR A 324 -11.555 9.779 -13.283 1.00 96.60 C \\\\nATOM 2582 OH TYR A 324 -12.750 10.575 -11.362 1.00 96.60 O \\\\nATOM 2583 CZ TYR A 324 -12.613 10.515 -12.714 1.00 96.60 C \\\\nATOM 2584 N GLY A 325 -13.566 8.706 -20.052 1.00 96.83 N \\\\nATOM 2585 CA GLY A 325 -13.546 8.778 -21.518 1.00 96.83 C \\\\nATOM 2586 C GLY A 325 -12.171 9.110 -22.114 1.00 96.83 C \\\\nATOM 2587 O GLY A 325 -12.085 9.595 -23.239 1.00 96.83 O \\\\nATOM 2588 N TRP A 326 -11.088 8.885 -21.368 1.00 96.86 N \\\\nATOM 2589 CA TRP A 326 -9.719 9.104 -21.832 1.00 96.86 C \\\\nATOM 2590 C TRP A 326 -9.160 7.863 -22.529 1.00 96.86 C \\\\nATOM 2591 CB TRP A 326 -8.824 9.520 -20.657 1.00 96.86 C \\\\nATOM 2592 O TRP A 326 -9.530 6.733 -22.211 1.00 96.86 O \\\\nATOM 2593 CG TRP A 326 -9.208 10.774 -19.932 1.00 96.86 C \\\\nATOM 2594 CD1 TRP A 326 -9.869 11.827 -20.467 1.00 96.86 C \\\\nATOM 2595 CD2 TRP A 326 -9.012 11.108 -18.521 1.00 96.86 C \\\\nATOM 2596 CE2 TRP A 326 -9.585 12.393 -18.279 1.00 96.86 C \\\\nATOM 2597 CE3 TRP A 326 -8.445 10.441 -17.410 1.00 96.86 C \\\\nATOM 2598 NE1 TRP A 326 -10.085 12.785 -19.500 1.00 96.86 N \\\\nATOM 2599 CH2 TRP A 326 -9.046 12.288 -15.922 1.00 96.86 C \\\\nATOM 2600 CZ2 TRP A 326 -9.597 12.988 -17.008 1.00 96.86 C \\\\nATOM 2601 CZ3 TRP A 326 -8.480 11.017 -16.125 1.00 96.86 C \\\\nATOM 2602 N HIS A 327 -8.192 8.071 -23.429 1.00 96.47 N \\\\nATOM 2603 CA HIS A 327 -7.456 6.975 -24.059 1.00 96.47 C \\\\nATOM 2604 C HIS A 327 -6.885 6.008 -22.993 1.00 96.47 C \\\\nATOM 2605 CB HIS A 327 -6.341 7.555 -24.942 1.00 96.47 C \\\\nATOM 2606 O HIS A 327 -6.330 6.481 -21.996 1.00 96.47 O \\\\nATOM 2607 CG HIS A 327 -5.666 6.498 -25.775 1.00 96.47 C \\\\nATOM 2608 CD2 HIS A 327 -6.181 5.901 -26.894 1.00 96.47 C \\\\nATOM 2609 ND1 HIS A 327 -4.451 5.902 -25.523 1.00 96.47 N \\\\nATOM 2610 CE1 HIS A 327 -4.247 4.955 -26.458 1.00 96.47 C \\\\nATOM 2611 NE2 HIS A 327 -5.285 4.912 -27.299 1.00 96.47 N \\\\nATOM 2612 N PRO A 328 -6.948 4.670 -23.168 1.00 94.55 N \\\\nATOM 2613 CA PRO A 328 -6.511 3.714 -22.142 1.00 94.55 C \\\\nATOM 2614 C PRO A 328 -5.063 3.912 -21.667 1.00 94.55 C \\\\nATOM 2615 CB PRO A 328 -6.707 2.331 -22.770 1.00 94.55 C \\\\nATOM 2616 O PRO A 328 -4.744 3.622 -20.514 1.00 94.55 O \\\\nATOM 2617 CG PRO A 328 -7.873 2.550 -23.731 1.00 94.55 C \\\\nATOM 2618 CD PRO A 328 -7.614 3.961 -24.254 1.00 94.55 C \\\\nATOM 2619 N ALA A 329 -4.203 4.470 -22.525 1.00 95.38 N \\\\nATOM 2620 CA ALA A 329 -2.805 4.780 -22.223 1.00 95.38 C \\\\nATOM 2621 C ALA A 329 -2.573 6.023 -21.339 1.00 95.38 C \\\\nATOM 2622 CB ALA A 329 -2.057 4.963 -23.546 1.00 95.38 C \\\\nATOM 2623 O ALA A 329 -1.431 6.232 -20.922 1.00 95.38 O \\\\nATOM 2624 N THR A 330 -3.592 6.859 -21.101 1.00 97.03 N \\\\nATOM 2625 CA THR A 330 -3.469 8.168 -20.437 1.00 97.03 C \\\\nATOM 2626 C THR A 330 -2.818 8.070 -19.056 1.00 97.03 C \\\\nATOM 2627 CB THR A 330 -4.839 8.868 -20.371 1.00 97.03 C \\\\nATOM 2628 O THR A 330 -3.058 7.131 -18.293 1.00 97.03 O \\\\nATOM 2629 CG2 THR A 330 -4.888 10.148 -19.534 1.00 97.03 C \\\\nATOM 2630 OG1 THR A 330 -5.162 9.258 -21.682 1.00 97.03 O \\\\nATOM 2631 N VAL A 331 -1.977 9.059 -18.743 1.00 98.32 N \\\\nATOM 2632 CA VAL A 331 -1.197 9.127 -17.503 1.00 98.32 C \\\\nATOM 2633 C VAL A 331 -1.662 10.319 -16.667 1.00 98.32 C \\\\nATOM 2634 CB VAL A 331 0.314 9.177 -17.801 1.00 98.32 C \\\\nATOM 2635 O VAL A 331 -1.331 11.473 -16.939 1.00 98.32 O \\\\nATOM 2636 CG1 VAL A 331 1.119 9.167 -16.496 1.00 98.32 C \\\\nATOM 2637 CG2 VAL A 331 0.754 7.971 -18.641 1.00 98.32 C \\\\nATOM 2638 N CYS A 332 -2.424 10.038 -15.616 1.00 97.93 N \\\\nATOM 2639 CA CYS A 332 -2.985 11.032 -14.711 1.00 97.93 C \\\\nATOM 2640 C CYS A 332 -1.943 11.484 -13.678 1.00 97.93 C \\\\nATOM 2641 CB CYS A 332 -4.212 10.433 -14.013 1.00 97.93 C \\\\nATOM 2642 O CYS A 332 -1.425 10.677 -12.904 1.00 97.93 O \\\\nATOM 2643 SG CYS A 332 -5.401 9.801 -15.228 1.00 97.93 S \\\\nATOM 2644 N LYS A 333 -1.662 12.786 -13.603 1.00 98.40 N \\\\nATOM 2645 CA LYS A 333 -0.823 13.367 -12.544 1.00 98.40 C \\\\nATOM 2646 C LYS A 333 -1.639 13.558 -11.262 1.00 98.40 C \\\\nATOM 2647 CB LYS A 333 -0.231 14.684 -13.062 1.00 98.40 C \\\\nATOM 2648 O LYS A 333 -2.661 14.236 -11.287 1.00 98.40 O \\\\nATOM 2649 CG LYS A 333 0.684 15.383 -12.046 1.00 98.40 C \\\\nATOM 2650 CD LYS A 333 1.203 16.686 -12.664 1.00 98.40 C \\\\nATOM 2651 CE LYS A 333 2.105 17.450 -11.694 1.00 98.40 C \\\\nATOM 2652 NZ LYS A 333 2.527 18.742 -12.291 1.00 98.40 N \\\\nATOM 2653 N ILE A 334 -1.145 13.050 -10.134 1.00 98.51 N \\\\nATOM 2654 CA ILE A 334 -1.685 13.314 -8.792 1.00 98.51 C \\\\nATOM 2655 C ILE A 334 -0.687 14.224 -8.050 1.00 98.51 C \\\\nATOM 2656 CB ILE A 334 -1.975 12.007 -8.019 1.00 98.51 C \\\\nATOM 2657 O ILE A 334 0.409 13.772 -7.703 1.00 98.51 O \\\\nATOM 2658 CG1 ILE A 334 -2.838 11.022 -8.842 1.00 98.51 C \\\\nATOM 2659 CG2 ILE A 334 -2.655 12.336 -6.674 1.00 98.51 C \\\\nATOM 2660 CD1 ILE A 334 -3.066 9.673 -8.151 1.00 98.51 C \\\\nATOM 2661 N PRO A 335 -1.013 15.514 -7.831 1.00 98.57 N \\\\nATOM 2662 CA PRO A 335 -0.159 16.433 -7.078 1.00 98.57 C \\\\nATOM 2663 C PRO A 335 -0.027 16.061 -5.586 1.00 98.57 C \\\\nATOM 2664 CB PRO A 335 -0.788 17.823 -7.244 1.00 98.57 C \\\\nATOM 2665 O PRO A 335 -0.885 15.351 -5.057 1.00 98.57 O \\\\nATOM 2666 CG PRO A 335 -1.649 17.696 -8.499 1.00 98.57 C \\\\nATOM 2667 CD PRO A 335 -2.117 16.247 -8.435 1.00 98.57 C \\\\nATOM 2668 N PRO A 336 0.997 16.579 -4.880 1.00 98.51 N \\\\nATOM 2669 CA PRO A 336 1.147 16.432 -3.429 1.00 98.51 C \\\\nATOM 2670 C PRO A 336 -0.131 16.770 -2.651 1.00 98.51 C \\\\nATOM 2671 CB PRO A 336 2.291 17.377 -3.044 1.00 98.51 C \\\\nATOM 2672 O PRO A 336 -0.737 17.819 -2.856 1.00 98.51 O \\\\nATOM 2673 CG PRO A 336 3.155 17.374 -4.300 1.00 98.51 C \\\\nATOM 2674 CD PRO A 336 2.115 17.342 -5.414 1.00 98.51 C \\\\nATOM 2675 N GLY A 337 -0.549 15.876 -1.752 1.00 95.96 N \\\\nATOM 2676 CA GLY A 337 -1.767 16.020 -0.948 1.00 95.96 C \\\\nATOM 2677 C GLY A 337 -3.084 15.715 -1.678 1.00 95.96 C \\\\nATOM 2678 O GLY A 337 -4.129 15.661 -1.028 1.00 95.96 O \\\\nATOM 2679 N CYS A 338 -3.066 15.485 -2.994 1.00 97.97 N \\\\nATOM 2680 CA CYS A 338 -4.239 15.055 -3.755 1.00 97.97 C \\\\nATOM 2681 C CYS A 338 -4.426 13.529 -3.706 1.00 97.97 C \\\\nATOM 2682 CB CYS A 338 -4.149 15.568 -5.200 1.00 97.97 C \\\\nATOM 2683 O CYS A 338 -3.501 12.769 -3.408 1.00 97.97 O \\\\nATOM 2684 SG CYS A 338 -4.101 17.385 -5.234 1.00 97.97 S \\\\nATOM 2685 N ASN A 339 -5.636 13.079 -4.040 1.00 97.19 N \\\\nATOM 2686 CA ASN A 339 -5.968 11.670 -4.234 1.00 97.19 C \\\\nATOM 2687 C ASN A 339 -6.816 11.470 -5.499 1.00 97.19 C \\\\nATOM 2688 CB ASN A 339 -6.641 11.094 -2.973 1.00 97.19 C \\\\nATOM 2689 O ASN A 339 -7.424 12.420 -5.991 1.00 97.19 O \\\\nATOM 2690 CG ASN A 339 -8.006 11.697 -2.697 1.00 97.19 C \\\\nATOM 2691 ND2 ASN A 339 -8.068 12.787 -1.966 1.00 97.19 N \\\\nATOM 2692 OD1 ASN A 339 -9.032 11.213 -3.137 1.00 97.19 O \\\\nATOM 2693 N LEU A 340 -6.834 10.241 -6.013 1.00 97.74 N \\\\nATOM 2694 CA LEU A 340 -7.588 9.821 -7.194 1.00 97.74 C \\\\nATOM 2695 C LEU A 340 -8.170 8.421 -6.967 1.00 97.74 C \\\\nATOM 2696 CB LEU A 340 -6.636 9.839 -8.406 1.00 97.74 C \\\\nATOM 2697 O LEU A 340 -7.485 7.548 -6.431 1.00 97.74 O \\\\nATOM 2698 CG LEU A 340 -7.252 9.450 -9.765 1.00 97.74 C \\\\nATOM 2699 CD1 LEU A 340 -8.359 10.414 -10.195 1.00 97.74 C \\\\nATOM 2700 CD2 LEU A 340 -6.159 9.459 -10.835 1.00 97.74 C \\\\nATOM 2701 N LYS A 341 -9.407 8.188 -7.420 1.00 97.97 N \\\\nATOM 2702 CA LYS A 341 -10.010 6.849 -7.498 1.00 97.97 C \\\\nATOM 2703 C LYS A 341 -9.441 6.115 -8.710 1.00 97.97 C \\\\nATOM 2704 CB LYS A 341 -11.538 6.971 -7.566 1.00 97.97 C \\\\nATOM 2705 O LYS A 341 -9.873 6.340 -9.838 1.00 97.97 O \\\\nATOM 2706 CG LYS A 341 -12.210 5.588 -7.497 1.00 97.97 C \\\\nATOM 2707 CD LYS A 341 -13.726 5.666 -7.704 1.00 97.97 C \\\\nATOM 2708 CE LYS A 341 -14.397 6.548 -6.645 1.00 97.97 C \\\\nATOM 2709 NZ LYS A 341 -15.870 6.475 -6.744 1.00 97.97 N \\\\nATOM 2710 N ILE A 342 -8.457 5.254 -8.483 1.00 98.34 N \\\\nATOM 2711 CA ILE A 342 -7.732 4.562 -9.552 1.00 98.34 C \\\\nATOM 2712 C ILE A 342 -8.460 3.309 -10.050 1.00 98.34 C \\\\nATOM 2713 CB ILE A 342 -6.280 4.249 -9.132 1.00 98.34 C \\\\nATOM 2714 O ILE A 342 -8.189 2.889 -11.168 1.00 98.34 O \\\\nATOM 2715 CG1 ILE A 342 -6.231 3.224 -7.976 1.00 98.34 C \\\\nATOM 2716 CG2 ILE A 342 -5.535 5.553 -8.793 1.00 98.34 C \\\\nATOM 2717 CD1 ILE A 342 -4.827 2.765 -7.596 1.00 98.34 C \\\\nATOM 2718 N PHE A 343 -9.368 2.720 -9.264 1.00 98.38 N \\\\nATOM 2719 CA PHE A 343 -10.139 1.539 -9.668 1.00 98.38 C \\\\nATOM 2720 C PHE A 343 -11.522 1.488 -9.004 1.00 98.38 C \\\\nATOM 2721 CB PHE A 343 -9.354 0.262 -9.343 1.00 98.38 C \\\\nATOM 2722 O PHE A 343 -11.668 1.935 -7.865 1.00 98.38 O \\\\nATOM 2723 CG PHE A 343 -9.807 -0.946 -10.137 1.00 98.38 C \\\\nATOM 2724 CD1 PHE A 343 -10.721 -1.865 -9.586 1.00 98.38 C \\\\nATOM 2725 CD2 PHE A 343 -9.294 -1.165 -11.430 1.00 98.38 C \\\\nATOM 2726 CE1 PHE A 343 -11.108 -2.997 -10.323 1.00 98.38 C \\\\nATOM 2727 CE2 PHE A 343 -9.684 -2.301 -12.160 1.00 98.38 C \\\\nATOM 2728 CZ PHE A 343 -10.580 -3.224 -11.602 1.00 98.38 C \\\\nATOM 2729 N ASN A 344 -12.511 0.898 -9.675 1.00 96.95 N \\\\nATOM 2730 CA ASN A 344 -13.810 0.538 -9.101 1.00 96.95 C \\\\nATOM 2731 C ASN A 344 -14.249 -0.852 -9.617 1.00 96.95 C \\\\nATOM 2732 CB ASN A 344 -14.811 1.671 -9.406 1.00 96.95 C \\\\nATOM 2733 O ASN A 344 -14.299 -1.098 -10.824 1.00 96.95 O \\\\nATOM 2734 CG ASN A 344 -16.252 1.329 -9.067 1.00 96.95 C \\\\nATOM 2735 ND2 ASN A 344 -16.917 2.009 -8.169 1.00 96.95 N \\\\nATOM 2736 OD1 ASN A 344 -16.815 0.393 -9.597 1.00 96.95 O \\\\nATOM 2737 N ASN A 345 -14.585 -1.756 -8.691 1.00 95.65 N \\\\nATOM 2738 CA ASN A 345 -14.955 -3.140 -8.994 1.00 95.65 C \\\\nATOM 2739 C ASN A 345 -16.313 -3.279 -9.705 1.00 95.65 C \\\\nATOM 2740 CB ASN A 345 -14.978 -3.970 -7.695 1.00 95.65 C \\\\nATOM 2741 O ASN A 345 -16.496 -4.245 -10.438 1.00 95.65 O \\\\nATOM 2742 CG ASN A 345 -13.622 -4.311 -7.098 1.00 95.65 C \\\\nATOM 2743 ND2 ASN A 345 -13.616 -5.022 -5.996 1.00 95.65 N \\\\nATOM 2744 OD1 ASN A 345 -12.567 -3.976 -7.606 1.00 95.65 O \\\\nATOM 2745 N GLN A 346 -17.266 -2.360 -9.509 1.00 95.14 N \\\\nATOM 2746 CA GLN A 346 -18.570 -2.389 -10.192 1.00 95.14 C \\\\nATOM 2747 C GLN A 346 -18.434 -2.020 -11.675 1.00 95.14 C \\\\nATOM 2748 CB GLN A 346 -19.572 -1.432 -9.520 1.00 95.14 C \\\\nATOM 2749 O GLN A 346 -19.045 -2.656 -12.528 1.00 95.14 O \\\\nATOM 2750 CG GLN A 346 -19.850 -1.744 -8.045 1.00 95.14 C \\\\nATOM 2751 CD GLN A 346 -20.867 -0.771 -7.458 1.00 95.14 C \\\\nATOM 2752 NE2 GLN A 346 -21.978 -1.246 -6.939 1.00 95.14 N \\\\nATOM 2753 OE1 GLN A 346 -20.692 0.434 -7.453 1.00 95.14 O \\\\nATOM 2754 N GLU A 347 -17.593 -1.034 -11.990 1.00 95.97 N \\\\nATOM 2755 CA GLU A 347 -17.256 -0.657 -13.367 1.00 95.97 C \\\\nATOM 2756 C GLU A 347 -16.535 -1.805 -14.087 1.00 95.97 C \\\\nATOM 2757 CB GLU A 347 -16.368 0.596 -13.346 1.00 95.97 C \\\\nATOM 2758 O GLU A 347 -16.882 -2.144 -15.217 1.00 95.97 O \\\\nATOM 2759 CG GLU A 347 -17.108 1.858 -12.867 1.00 95.97 C \\\\nATOM 2760 CD GLU A 347 -16.146 3.008 -12.540 1.00 95.97 C \\\\nATOM 2761 OE1 GLU A 347 -16.567 4.018 -11.935 1.00 95.97 O \\\\nATOM 2762 OE2 GLU A 347 -14.927 2.898 -12.799 1.00 95.97 O \\\\nATOM 2763 N PHE A 348 -15.586 -2.464 -13.409 1.00 97.03 N \\\\nATOM 2764 CA PHE A 348 -14.939 -3.667 -13.936 1.00 97.03 C \\\\nATOM 2765 C PHE A 348 -15.919 -4.841 -14.102 1.00 97.03 C \\\\nATOM 2766 CB PHE A 348 -13.752 -4.044 -13.043 1.00 97.03 C \\\\nATOM 2767 O PHE A 348 -15.876 -5.515 -15.126 1.00 97.03 O \\\\nATOM 2768 CG PHE A 348 -13.012 -5.279 -13.524 1.00 97.03 C \\\\nATOM 2769 CD1 PHE A 348 -13.244 -6.527 -12.912 1.00 97.03 C \\\\nATOM 2770 CD2 PHE A 348 -12.127 -5.191 -14.616 1.00 97.03 C \\\\nATOM 2771 CE1 PHE A 348 -12.591 -7.679 -13.387 1.00 97.03 C \\\\nATOM 2772 CE2 PHE A 348 -11.474 -6.344 -15.089 1.00 97.03 C \\\\nATOM 2773 CZ PHE A 348 -11.706 -7.586 -14.474 1.00 97.03 C \\\\nATOM 2774 N ALA A 349 -16.836 -5.061 -13.151 1.00 95.38 N \\\\nATOM 2775 CA ALA A 349 -17.877 -6.089 -13.243 1.00 95.38 C \\\\nATOM 2776 C ALA A 349 -18.769 -5.904 -14.478 1.00 95.38 C \\\\nATOM 2777 CB ALA A 349 -18.758 -6.034 -11.985 1.00 95.38 C \\\\nATOM 2778 O ALA A 349 -19.033 -6.861 -15.205 1.00 95.38 O \\\\nATOM 2779 N ALA A 350 -19.224 -4.669 -14.713 1.00 95.44 N \\\\nATOM 2780 CA ALA A 350 -20.069 -4.329 -15.850 1.00 95.44 C \\\\nATOM 2781 C ALA A 350 -19.336 -4.555 -17.180 1.00 95.44 C \\\\nATOM 2782 CB ALA A 350 -20.535 -2.877 -15.689 1.00 95.44 C \\\\nATOM 2783 O ALA A 350 -19.901 -5.157 -18.091 1.00 95.44 O \\\\nATOM 2784 N LEU A 351 -18.068 -4.140 -17.268 1.00 95.45 N \\\\nATOM 2785 CA LEU A 351 -17.235 -4.369 -18.446 1.00 95.45 C \\\\nATOM 2786 C LEU A 351 -16.982 -5.863 -18.691 1.00 95.45 C \\\\nATOM 2787 CB LEU A 351 -15.927 -3.589 -18.264 1.00 95.45 C \\\\nATOM 2788 O LEU A 351 -17.164 -6.335 -19.808 1.00 95.45 O \\\\nATOM 2789 CG LEU A 351 -14.970 -3.702 -19.462 1.00 95.45 C \\\\nATOM 2790 CD1 LEU A 351 -15.584 -3.164 -20.755 1.00 95.45 C \\\\nATOM 2791 CD2 LEU A 351 -13.718 -2.901 -19.127 1.00 95.45 C \\\\nATOM 2792 N LEU A 352 -16.637 -6.626 -17.649 1.00 96.13 N \\\\nATOM 2793 CA LEU A 352 -16.427 -8.072 -17.739 1.00 96.13 C \\\\nATOM 2794 C LEU A 352 -17.687 -8.794 -18.240 1.00 96.13 C \\\\nATOM 2795 CB LEU A 352 -15.943 -8.577 -16.365 1.00 96.13 C \\\\nATOM 2796 O LEU A 352 -17.603 -9.603 -19.160 1.00 96.13 O \\\\nATOM 2797 CG LEU A 352 -15.683 -10.092 -16.272 1.00 96.13 C \\\\nATOM 2798 CD1 LEU A 352 -14.689 -10.587 -17.318 1.00 96.13 C \\\\nATOM 2799 CD2 LEU A 352 -15.118 -10.422 -14.887 1.00 96.13 C \\\\nATOM 2800 N ALA A 353 -18.862 -8.453 -17.703 1.00 94.39 N \\\\nATOM 2801 CA ALA A 353 -20.137 -9.006 -18.157 1.00 94.39 C \\\\nATOM 2802 C ALA A 353 -20.473 -8.643 -19.618 1.00 94.39 C \\\\nATOM 2803 CB ALA A 353 -21.234 -8.528 -17.198 1.00 94.39 C \\\\nATOM 2804 O ALA A 353 -21.095 -9.440 -20.318 1.00 94.39 O \\\\nATOM 2805 N GLN A 354 -20.057 -7.466 -20.099 1.00 94.04 N \\\\nATOM 2806 CA GLN A 354 -20.220 -7.067 -21.500 1.00 94.04 C \\\\nATOM 2807 C GLN A 354 -19.262 -7.839 -22.420 1.00 94.04 C \\\\nATOM 2808 CB GLN A 354 -20.038 -5.547 -21.636 1.00 94.04 C \\\\nATOM 2809 O GLN A 354 -19.718 -8.442 -23.394 1.00 94.04 O \\\\nATOM 2810 CG GLN A 354 -21.235 -4.775 -21.055 1.00 94.04 C \\\\nATOM 2811 CD GLN A 354 -20.982 -3.275 -20.915 1.00 94.04 C \\\\nATOM 2812 NE2 GLN A 354 -21.886 -2.546 -20.298 1.00 94.04 N \\\\nATOM 2813 OE1 GLN A 354 -19.994 -2.713 -21.353 1.00 94.04 O \\\\nATOM 2814 N SER A 355 -17.968 -7.887 -22.088 1.00 94.46 N \\\\nATOM 2815 CA SER A 355 -16.929 -8.520 -22.912 1.00 94.46 C \\\\nATOM 2816 C SER A 355 -17.077 -10.034 -23.059 1.00 94.46 C \\\\nATOM 2817 CB SER A 355 -15.537 -8.197 -22.368 1.00 94.46 C \\\\nATOM 2818 O SER A 355 -16.649 -10.571 -24.074 1.00 94.46 O \\\\nATOM 2819 OG SER A 355 -15.291 -6.809 -22.469 1.00 94.46 O \\\\nATOM 2820 N VAL A 356 -17.745 -10.732 -22.131 1.00 92.71 N \\\\nATOM 2821 CA VAL A 356 -18.093 -12.160 -22.307 1.00 92.71 C \\\\nATOM 2822 C VAL A 356 -18.860 -12.407 -23.613 1.00 92.71 C \\\\nATOM 2823 CB VAL A 356 -18.887 -12.669 -21.087 1.00 92.71 C \\\\nATOM 2824 O VAL A 356 -18.597 -13.386 -24.306 1.00 92.71 O \\\\nATOM 2825 CG1 VAL A 356 -19.590 -14.012 -21.311 1.00 92.71 C \\\\nATOM 2826 CG2 VAL A 356 -17.941 -12.871 -19.900 1.00 92.71 C \\\\nATOM 2827 N ASN A 357 -19.745 -11.487 -24.013 1.00 89.37 N \\\\nATOM 2828 CA ASN A 357 -20.513 -11.601 -25.261 1.00 89.37 C \\\\nATOM 2829 C ASN A 357 -19.690 -11.255 -26.519 1.00 89.37 C \\\\nATOM 2830 CB ASN A 357 -21.776 -10.732 -25.163 1.00 89.37 C \\\\nATOM 2831 O ASN A 357 -20.150 -11.488 -27.633 1.00 89.37 O \\\\nATOM 2832 CG ASN A 357 -22.604 -11.057 -23.936 1.00 89.37 C \\\\nATOM 2833 ND2 ASN A 357 -22.554 -10.217 -22.930 1.00 89.37 N \\\\nATOM 2834 OD1 ASN A 357 -23.262 -12.078 -23.847 1.00 89.37 O \\\\nATOM 2835 N GLN A 358 -18.487 -10.699 -26.346 1.00 91.08 N \\\\nATOM 2836 CA GLN A 358 -17.529 -10.374 -27.411 1.00 91.08 C \\\\nATOM 2837 C GLN A 358 -16.492 -11.499 -27.621 1.00 91.08 C \\\\nATOM 2838 CB GLN A 358 -16.841 -9.038 -27.074 1.00 91.08 C \\\\nATOM 2839 O GLN A 358 -15.707 -11.448 -28.566 1.00 91.08 O \\\\nATOM 2840 CG GLN A 358 -17.800 -7.840 -26.950 1.00 91.08 C \\\\nATOM 2841 CD GLN A 358 -17.139 -6.596 -26.353 1.00 91.08 C \\\\nATOM 2842 NE2 GLN A 358 -17.807 -5.465 -26.381 1.00 91.08 N \\\\nATOM 2843 OE1 GLN A 358 -16.049 -6.607 -25.801 1.00 91.08 O \\\\nATOM 2844 N GLY A 359 -16.494 -12.529 -26.765 1.00 90.37 N \\\\nATOM 2845 CA GLY A 359 -15.665 -13.728 -26.894 1.00 90.37 C \\\\nATOM 2846 C GLY A 359 -14.324 -13.684 -26.151 1.00 90.37 C \\\\nATOM 2847 O GLY A 359 -14.008 -12.750 -25.412 1.00 90.37 O \\\\nATOM 2848 N PHE A 360 -13.531 -14.747 -26.339 1.00 90.85 N \\\\nATOM 2849 CA PHE A 360 -12.313 -15.020 -25.561 1.00 90.85 C \\\\nATOM 2850 C PHE A 360 -11.310 -13.865 -25.550 1.00 90.85 C \\\\nATOM 2851 CB PHE A 360 -11.668 -16.329 -26.041 1.00 90.85 C \\\\nATOM 2852 O PHE A 360 -10.863 -13.465 -24.477 1.00 90.85 O \\\\nATOM 2853 CG PHE A 360 -10.561 -16.809 -25.121 1.00 90.85 C \\\\nATOM 2854 CD1 PHE A 360 -9.265 -16.267 -25.227 1.00 90.85 C \\\\nATOM 2855 CD2 PHE A 360 -10.837 -17.763 -24.121 1.00 90.85 C \\\\nATOM 2856 CE1 PHE A 360 -8.253 -16.670 -24.338 1.00 90.85 C \\\\nATOM 2857 CE2 PHE A 360 -9.824 -18.168 -23.234 1.00 90.85 C \\\\nATOM 2858 CZ PHE A 360 -8.532 -17.623 -23.343 1.00 90.85 C \\\\nATOM 2859 N GLU A 361 -10.982 -13.310 -26.717 1.00 91.71 N \\\\nATOM 2860 CA GLU A 361 -9.951 -12.274 -26.825 1.00 91.71 C \\\\nATOM 2861 C GLU A 361 -10.351 -10.987 -26.091 1.00 91.71 C \\\\nATOM 2862 CB GLU A 361 -9.656 -12.018 -28.313 1.00 91.71 C \\\\nATOM 2863 O GLU A 361 -9.552 -10.427 -25.345 1.00 91.71 O \\\\nATOM 2864 CG GLU A 361 -8.429 -11.123 -28.545 1.00 91.71 C \\\\nATOM 2865 CD GLU A 361 -7.154 -11.667 -27.883 1.00 91.71 C \\\\nATOM 2866 OE1 GLU A 361 -6.342 -10.831 -27.422 1.00 91.71 O \\\\nATOM 2867 OE2 GLU A 361 -7.010 -12.908 -27.800 1.00 91.71 O \\\\nATOM 2868 N ALA A 362 -11.613 -10.562 -26.213 1.00 93.21 N \\\\nATOM 2869 CA ALA A 362 -12.117 -9.369 -25.538 1.00 93.21 C \\\\nATOM 2870 C ALA A 362 -11.999 -9.481 -24.010 1.00 93.21 C \\\\nATOM 2871 CB ALA A 362 -13.566 -9.150 -25.973 1.00 93.21 C \\\\nATOM 2872 O ALA A 362 -11.527 -8.553 -23.355 1.00 93.21 O \\\\nATOM 2873 N VAL A 363 -12.357 -10.639 -23.441 1.00 93.93 N \\\\nATOM 2874 CA VAL A 363 -12.168 -10.907 -22.007 1.00 93.93 C \\\\nATOM 2875 C VAL A 363 -10.682 -11.016 -21.660 1.00 93.93 C \\\\nATOM 2876 CB VAL A 363 -12.953 -12.156 -21.569 1.00 93.93 C \\\\nATOM 2877 O VAL A 363 -10.252 -10.433 -20.670 1.00 93.93 O \\\\nATOM 2878 CG1 VAL A 363 -12.751 -12.502 -20.091 1.00 93.93 C \\\\nATOM 2879 CG2 VAL A 363 -14.456 -11.915 -21.749 1.00 93.93 C \\\\nATOM 2880 N TYR A 364 -9.862 -11.685 -22.472 1.00 93.20 N \\\\nATOM 2881 CA TYR A 364 -8.427 -11.825 -22.207 1.00 93.20 C \\\\nATOM 2882 C TYR A 364 -7.715 -10.462 -22.122 1.00 93.20 C \\\\nATOM 2883 CB TYR A 364 -7.800 -12.732 -23.272 1.00 93.20 C \\\\nATOM 2884 O TYR A 364 -6.920 -10.228 -21.204 1.00 93.20 O \\\\nATOM 2885 CG TYR A 364 -6.345 -13.042 -22.995 1.00 93.20 C \\\\nATOM 2886 CD1 TYR A 364 -5.330 -12.355 -23.688 1.00 93.20 C \\\\nATOM 2887 CD2 TYR A 364 -6.013 -13.994 -22.012 1.00 93.20 C \\\\nATOM 2888 CE1 TYR A 364 -3.979 -12.605 -23.380 1.00 93.20 C \\\\nATOM 2889 CE2 TYR A 364 -4.663 -14.253 -21.707 1.00 93.20 C \\\\nATOM 2890 OH TYR A 364 -2.341 -13.787 -22.088 1.00 93.20 O \\\\nATOM 2891 CZ TYR A 364 -3.645 -13.550 -22.388 1.00 93.20 C \\\\nATOM 2892 N GLN A 365 -8.072 -9.512 -22.994 1.00 93.42 N \\\\nATOM 2893 CA GLN A 365 -7.553 -8.140 -22.965 1.00 93.42 C \\\\nATOM 2894 C GLN A 365 -7.907 -7.379 -21.672 1.00 93.42 C \\\\nATOM 2895 CB GLN A 365 -8.040 -7.370 -24.206 1.00 93.42 C \\\\nATOM 2896 O GLN A 365 -7.131 -6.515 -21.249 1.00 93.42 O \\\\nATOM 2897 CG GLN A 365 -7.428 -7.884 -25.524 1.00 93.42 C \\\\nATOM 2898 CD GLN A 365 -5.914 -7.725 -25.629 1.00 93.42 C \\\\nATOM 2899 NE2 GLN A 365 -5.257 -8.548 -26.410 1.00 93.42 N \\\\nATOM 2900 OE1 GLN A 365 -5.283 -6.872 -25.015 1.00 93.42 O \\\\nATOM 2901 N LEU A 366 -8.993 -7.738 -20.967 1.00 95.17 N \\\\nATOM 2902 CA LEU A 366 -9.334 -7.145 -19.664 1.00 95.17 C \\\\nATOM 2903 C LEU A 366 -8.290 -7.423 -18.574 1.00 95.17 C \\\\nATOM 2904 CB LEU A 366 -10.722 -7.583 -19.165 1.00 95.17 C \\\\nATOM 2905 O LEU A 366 -8.277 -6.712 -17.570 1.00 95.17 O \\\\nATOM 2906 CG LEU A 366 -11.909 -7.249 -20.080 1.00 95.17 C \\\\nATOM 2907 CD1 LEU A 366 -13.200 -7.665 -19.379 1.00 95.17 C \\\\nATOM 2908 CD2 LEU A 366 -11.996 -5.757 -20.398 1.00 95.17 C \\\\nATOM 2909 N THR A 367 -7.352 -8.355 -18.783 1.00 95.31 N \\\\nATOM 2910 CA THR A 367 -6.177 -8.527 -17.907 1.00 95.31 C \\\\nATOM 2911 C THR A 367 -5.436 -7.198 -17.716 1.00 95.31 C \\\\nATOM 2912 CB THR A 367 -5.206 -9.573 -18.482 1.00 95.31 C \\\\nATOM 2913 O THR A 367 -5.001 -6.880 -16.610 1.00 95.31 O \\\\nATOM 2914 CG2 THR A 367 -4.080 -9.922 -17.507 1.00 95.31 C \\\\nATOM 2915 OG1 THR A 367 -5.878 -10.777 -18.753 1.00 95.31 O \\\\nATOM 2916 N ARG A 368 -5.376 -6.362 -18.767 1.00 94.06 N \\\\nATOM 2917 CA ARG A 368 -4.761 -5.024 -18.728 1.00 94.06 C \\\\nATOM 2918 C ARG A 368 -5.491 -4.059 -17.790 1.00 94.06 C \\\\nATOM 2919 CB ARG A 368 -4.712 -4.429 -20.146 1.00 94.06 C \\\\nATOM 2920 O ARG A 368 -4.845 -3.193 -17.211 1.00 94.06 O \\\\nATOM 2921 CG ARG A 368 -3.878 -5.258 -21.138 1.00 94.06 C \\\\nATOM 2922 CD ARG A 368 -3.914 -4.608 -22.527 1.00 94.06 C \\\\nATOM 2923 NE ARG A 368 -3.118 -5.365 -23.510 1.00 94.06 N \\\\nATOM 2924 NH1 ARG A 368 -3.408 -3.937 -25.296 1.00 94.06 N \\\\nATOM 2925 NH2 ARG A 368 -2.269 -5.831 -25.575 1.00 94.06 N \\\\nATOM 2926 CZ ARG A 368 -2.938 -5.042 -24.782 1.00 94.06 C \\\\nATOM 2927 N MET A 369 -6.806 -4.208 -17.603 1.00 95.92 N \\\\nATOM 2928 CA MET A 369 -7.591 -3.369 -16.685 1.00 95.92 C \\\\nATOM 2929 C MET A 369 -7.190 -3.597 -15.226 1.00 95.92 C \\\\nATOM 2930 CB MET A 369 -9.098 -3.637 -16.840 1.00 95.92 C \\\\nATOM 2931 O MET A 369 -7.254 -2.670 -14.421 1.00 95.92 O \\\\nATOM 2932 CG MET A 369 -9.631 -3.405 -18.258 1.00 95.92 C \\\\nATOM 2933 SD MET A 369 -9.534 -1.698 -18.853 1.00 95.92 S \\\\nATOM 2934 CE MET A 369 -10.858 -0.933 -17.889 1.00 95.92 C \\\\nATOM 2935 N CYS A 370 -6.756 -4.814 -14.892 1.00 97.33 N \\\\nATOM 2936 CA CYS A 370 -6.361 -5.210 -13.542 1.00 97.33 C \\\\nATOM 2937 C CYS A 370 -4.930 -4.783 -13.163 1.00 97.33 C \\\\nATOM 2938 CB CYS A 370 -6.520 -6.726 -13.419 1.00 97.33 C \\\\nATOM 2939 O CYS A 370 -4.534 -4.961 -12.006 1.00 97.33 O \\\\nATOM 2940 SG CYS A 370 -8.188 -7.266 -13.897 1.00 97.33 S \\\\nATOM 2941 N THR A 371 -4.166 -4.227 -14.112 1.00 97.75 N \\\\nATOM 2942 CA THR A 371 -2.799 -3.731 -13.912 1.00 97.75 C \\\\nATOM 2943 C THR A 371 -2.781 -2.203 -13.909 1.00 97.75 C \\\\nATOM 2944 CB THR A 371 -1.831 -4.295 -14.965 1.00 97.75 C \\\\nATOM 2945 O THR A 371 -3.195 -1.556 -14.869 1.00 97.75 O \\\\nATOM 2946 CG2 THR A 371 -0.398 -3.796 -14.784 1.00 97.75 C \\\\nATOM 2947 OG1 THR A 371 -1.781 -5.699 -14.867 1.00 97.75 O \\\\nATOM 2948 N ILE A 372 -2.257 -1.608 -12.836 1.00 98.54 N \\\\nATOM 2949 CA ILE A 372 -2.121 -0.152 -12.686 1.00 98.54 C \\\\nATOM 2950 C ILE A 372 -0.647 0.191 -12.503 1.00 98.54 C \\\\nATOM 2951 CB ILE A 372 -2.996 0.374 -11.525 1.00 98.54 C \\\\nATOM 2952 O ILE A 372 0.026 -0.382 -11.648 1.00 98.54 O \\\\nATOM 2953 CG1 ILE A 372 -4.488 0.075 -11.799 1.00 98.54 C \\\\nATOM 2954 CG2 ILE A 372 -2.745 1.881 -11.307 1.00 98.54 C \\\\nATOM 2955 CD1 ILE A 372 -5.428 0.435 -10.644 1.00 98.54 C \\\\nATOM 2956 N ARG A 373 -0.136 1.158 -13.267 1.00 98.65 N \\\\nATOM 2957 CA ARG A 373 1.268 1.590 -13.178 1.00 98.65 C \\\\nATOM 2958 C ARG A 373 1.374 2.972 -12.567 1.00 98.65 C \\\\nATOM 2959 CB ARG A 373 1.950 1.501 -14.547 1.00 98.65 C \\\\nATOM 2960 O ARG A 373 0.597 3.860 -12.919 1.00 98.65 O \\\\nATOM 2961 CG ARG A 373 1.956 0.049 -15.037 1.00 98.65 C \\\\nATOM 2962 CD ARG A 373 2.780 -0.093 -16.310 1.00 98.65 C \\\\nATOM 2963 NE ARG A 373 2.808 -1.498 -16.728 1.00 98.65 N \\\\nATOM 2964 NH1 ARG A 373 1.773 -1.380 -18.785 1.00 98.65 N \\\\nATOM 2965 NH2 ARG A 373 2.486 -3.339 -17.937 1.00 98.65 N \\\\nATOM 2966 CZ ARG A 373 2.352 -2.053 -17.828 1.00 98.65 C \\\\nATOM 2967 N MET A 374 2.340 3.170 -11.670 1.00 98.70 N \\\\nATOM 2968 CA MET A 374 2.595 4.475 -11.055 1.00 98.70 C \\\\nATOM 2969 C MET A 374 4.073 4.844 -11.050 1.00 98.70 C \\\\nATOM 2970 CB MET A 374 2.054 4.573 -9.625 1.00 98.70 C \\\\nATOM 2971 O MET A 374 4.883 4.113 -10.489 1.00 98.70 O \\\\nATOM 2972 CG MET A 374 0.607 4.118 -9.491 1.00 98.70 C \\\\nATOM 2973 SD MET A 374 -0.088 4.536 -7.879 1.00 98.70 S \\\\nATOM 2974 CE MET A 374 -1.719 3.823 -8.145 1.00 98.70 C \\\\nATOM 2975 N SER A 375 4.416 6.010 -11.595 1.00 98.78 N \\\\nATOM 2976 CA SER A 375 5.757 6.597 -11.498 1.00 98.78 C \\\\nATOM 2977 C SER A 375 5.819 7.646 -10.391 1.00 98.78 C \\\\nATOM 2978 CB SER A 375 6.193 7.202 -12.831 1.00 98.78 C \\\\nATOM 2979 O SER A 375 4.895 8.447 -10.214 1.00 98.78 O \\\\nATOM 2980 OG SER A 375 7.441 7.846 -12.697 1.00 98.78 O \\\\nATOM 2981 N PHE A 376 6.942 7.680 -9.677 1.00 98.81 N \\\\nATOM 2982 CA PHE A 376 7.247 8.703 -8.685 1.00 98.81 C \\\\nATOM 2983 C PHE A 376 8.044 9.849 -9.319 1.00 98.81 C \\\\nATOM 2984 CB PHE A 376 8.019 8.080 -7.515 1.00 98.81 C \\\\nATOM 2985 O PHE A 376 9.028 9.620 -10.023 1.00 98.81 O \\\\nATOM 2986 CG PHE A 376 7.275 6.993 -6.762 1.00 98.81 C \\\\nATOM 2987 CD1 PHE A 376 6.403 7.336 -5.711 1.00 98.81 C \\\\nATOM 2988 CD2 PHE A 376 7.459 5.639 -7.102 1.00 98.81 C \\\\nATOM 2989 CE1 PHE A 376 5.723 6.330 -5.001 1.00 98.81 C \\\\nATOM 2990 CE2 PHE A 376 6.777 4.635 -6.393 1.00 98.81 C \\\\nATOM 2991 CZ PHE A 376 5.910 4.979 -5.342 1.00 98.81 C \\\\nATOM 2992 N VAL A 377 7.682 11.099 -9.004 1.00 98.56 N \\\\nATOM 2993 CA VAL A 377 8.406 12.346 -9.346 1.00 98.56 C \\\\nATOM 2994 C VAL A 377 8.447 12.701 -10.843 1.00 98.56 C \\\\nATOM 2995 CB VAL A 377 9.846 12.335 -8.774 1.00 98.56 C \\\\nATOM 2996 O VAL A 377 8.438 13.885 -11.182 1.00 98.56 O \\\\nATOM 2997 CG1 VAL A 377 10.498 13.724 -8.771 1.00 98.56 C \\\\nATOM 2998 CG2 VAL A 377 9.970 11.778 -7.346 1.00 98.56 C \\\\nATOM 2999 N LYS A 378 8.509 11.725 -11.758 1.00 98.24 N \\\\nATOM 3000 CA LYS A 378 8.670 11.928 -13.209 1.00 98.24 C \\\\nATOM 3001 C LYS A 378 7.483 11.353 -13.989 1.00 98.24 C \\\\nATOM 3002 CB LYS A 378 9.996 11.299 -13.693 1.00 98.24 C \\\\nATOM 3003 O LYS A 378 7.233 10.155 -13.919 1.00 98.24 O \\\\nATOM 3004 CG LYS A 378 11.266 11.754 -12.948 1.00 98.24 C \\\\nATOM 3005 CD LYS A 378 11.501 13.272 -12.973 1.00 98.24 C \\\\nATOM 3006 CE LYS A 378 12.773 13.608 -12.185 1.00 98.24 C \\\\nATOM 3007 NZ LYS A 378 12.933 15.073 -12.002 1.00 98.24 N \\\\nATOM 3008 N GLY A 379 6.803 12.192 -14.767 1.00 97.29 N \\\\nATOM 3009 CA GLY A 379 5.748 11.760 -15.689 1.00 97.29 C \\\\nATOM 3010 C GLY A 379 6.277 11.053 -16.939 1.00 97.29 C \\\\nATOM 3011 O GLY A 379 7.464 11.159 -17.273 1.00 97.29 O \\\\nATOM 3012 N TRP A 380 5.368 10.348 -17.612 1.00 98.27 N \\\\nATOM 3013 CA TRP A 380 5.543 9.736 -18.930 1.00 98.27 C \\\\nATOM 3014 C TRP A 380 4.223 9.790 -19.721 1.00 98.27 C \\\\nATOM 3015 CB TRP A 380 6.049 8.290 -18.793 1.00 98.27 C \\\\nATOM 3016 O TRP A 380 3.188 10.128 -19.148 1.00 98.27 O \\\\nATOM 3017 CG TRP A 380 5.001 7.249 -18.540 1.00 98.27 C \\\\nATOM 3018 CD1 TRP A 380 4.437 6.468 -19.491 1.00 98.27 C \\\\nATOM 3019 CD2 TRP A 380 4.327 6.901 -17.293 1.00 98.27 C \\\\nATOM 3020 CE2 TRP A 380 3.395 5.855 -17.564 1.00 98.27 C \\\\nATOM 3021 CE3 TRP A 380 4.395 7.369 -15.962 1.00 98.27 C \\\\nATOM 3022 NE1 TRP A 380 3.495 5.638 -18.919 1.00 98.27 N \\\\nATOM 3023 CH2 TRP A 380 2.678 5.771 -15.259 1.00 98.27 C \\\\nATOM 3024 CZ2 TRP A 380 2.605 5.271 -16.567 1.00 98.27 C \\\\nATOM 3025 CZ3 TRP A 380 3.563 6.822 -14.967 1.00 98.27 C \\\\nATOM 3026 N GLY A 381 4.259 9.453 -21.010 1.00 95.83 N \\\\nATOM 3027 CA GLY A 381 3.134 9.560 -21.944 1.00 95.83 C \\\\nATOM 3028 C GLY A 381 3.169 10.863 -22.749 1.00 95.83 C \\\\nATOM 3029 O GLY A 381 4.135 11.616 -22.647 1.00 95.83 O \\\\nATOM 3030 N ALA A 382 2.109 11.126 -23.522 1.00 92.96 N \\\\nATOM 3031 CA ALA A 382 2.044 12.198 -24.528 1.00 92.96 C \\\\nATOM 3032 C ALA A 382 2.542 13.575 -24.035 1.00 92.96 C \\\\nATOM 3033 CB ALA A 382 0.592 12.282 -25.020 1.00 92.96 C \\\\nATOM 3034 O ALA A 382 3.350 14.214 -24.702 1.00 92.96 O \\\\nATOM 3035 N GLU A 383 2.152 13.976 -22.821 1.00 91.46 N \\\\nATOM 3036 CA GLU A 383 2.499 15.270 -22.206 1.00 91.46 C \\\\nATOM 3037 C GLU A 383 3.948 15.372 -21.678 1.00 91.46 C \\\\nATOM 3038 CB GLU A 383 1.507 15.559 -21.063 1.00 91.46 C \\\\nATOM 3039 O GLU A 383 4.318 16.347 -21.019 1.00 91.46 O \\\\nATOM 3040 CG GLU A 383 0.031 15.522 -21.482 1.00 91.46 C \\\\nATOM 3041 CD GLU A 383 -0.228 16.402 -22.707 1.00 91.46 C \\\\nATOM 3042 OE1 GLU A 383 -0.810 15.863 -23.671 1.00 91.46 O \\\\nATOM 3043 OE2 GLU A 383 0.203 17.575 -22.659 1.00 91.46 O \\\\nATOM 3044 N TYR A 384 4.787 14.351 -21.888 1.00 95.61 N \\\\nATOM 3045 CA TYR A 384 6.121 14.262 -21.297 1.00 95.61 C \\\\nATOM 3046 C TYR A 384 7.166 13.757 -22.295 1.00 95.61 C \\\\nATOM 3047 CB TYR A 384 6.084 13.357 -20.051 1.00 95.61 C \\\\nATOM 3048 O TYR A 384 6.925 12.880 -23.113 1.00 95.61 O \\\\nATOM 3049 CG TYR A 384 5.120 13.811 -18.968 1.00 95.61 C \\\\nATOM 3050 CD1 TYR A 384 5.477 14.837 -18.069 1.00 95.61 C \\\\nATOM 3051 CD2 TYR A 384 3.824 13.267 -18.924 1.00 95.61 C \\\\nATOM 3052 CE1 TYR A 384 4.523 15.344 -17.162 1.00 95.61 C \\\\nATOM 3053 CE2 TYR A 384 2.872 13.758 -18.015 1.00 95.61 C \\\\nATOM 3054 OH TYR A 384 2.248 15.383 -16.376 1.00 95.61 O \\\\nATOM 3055 CZ TYR A 384 3.208 14.827 -17.161 1.00 95.61 C \\\\nATOM 3056 N ARG A 385 8.418 14.209 -22.132 1.00 95.60 N \\\\nATOM 3057 CA ARG A 385 9.572 13.721 -22.919 1.00 95.60 C \\\\nATOM 3058 C ARG A 385 9.787 12.195 -22.835 1.00 95.60 C \\\\nATOM 3059 CB ARG A 385 10.822 14.516 -22.492 1.00 95.60 C \\\\nATOM 3060 O ARG A 385 10.451 11.618 -23.689 1.00 95.60 O \\\\nATOM 3061 CG ARG A 385 12.085 14.098 -23.262 1.00 95.60 C \\\\nATOM 3062 CD ARG A 385 13.284 15.003 -22.977 1.00 95.60 C \\\\nATOM 3063 NE ARG A 385 14.513 14.388 -23.516 1.00 95.60 N \\\\nATOM 3064 NH1 ARG A 385 15.973 15.009 -21.858 1.00 95.60 N \\\\nATOM 3065 NH2 ARG A 385 16.623 13.531 -23.347 1.00 95.60 N \\\\nATOM 3066 CZ ARG A 385 15.687 14.316 -22.919 1.00 95.60 C \\\\nATOM 3067 N ARG A 386 9.276 11.538 -21.790 1.00 96.56 N \\\\nATOM 3068 CA ARG A 386 9.328 10.080 -21.615 1.00 96.56 C \\\\nATOM 3069 C ARG A 386 8.064 9.473 -22.206 1.00 96.56 C \\\\nATOM 3070 CB ARG A 386 9.416 9.737 -20.120 1.00 96.56 C \\\\nATOM 3071 O ARG A 386 7.011 9.641 -21.612 1.00 96.56 O \\\\nATOM 3072 CG ARG A 386 10.779 10.093 -19.533 1.00 96.56 C \\\\nATOM 3073 CD ARG A 386 10.772 9.857 -18.020 1.00 96.56 C \\\\nATOM 3074 NE ARG A 386 12.126 10.031 -17.471 1.00 96.56 N \\\\nATOM 3075 NH1 ARG A 386 12.152 12.322 -17.440 1.00 96.56 N \\\\nATOM 3076 NH2 ARG A 386 14.040 11.183 -17.055 1.00 96.56 N \\\\nATOM 3077 CZ ARG A 386 12.764 11.175 -17.316 1.00 96.56 C \\\\nATOM 3078 N GLN A 387 8.162 8.731 -23.303 1.00 96.27 N \\\\nATOM 3079 CA GLN A 387 6.978 8.072 -23.868 1.00 96.27 C \\\\nATOM 3080 C GLN A 387 6.599 6.798 -23.101 1.00 96.27 C \\\\nATOM 3081 CB GLN A 387 7.175 7.829 -25.375 1.00 96.27 C \\\\nATOM 3082 O GLN A 387 5.418 6.542 -22.877 1.00 96.27 O \\\\nATOM 3083 CG GLN A 387 7.368 9.140 -26.168 1.00 96.27 C \\\\nATOM 3084 CD GLN A 387 6.268 10.168 -25.894 1.00 96.27 C \\\\nATOM 3085 NE2 GLN A 387 6.591 11.439 -25.828 1.00 96.27 N \\\\nATOM 3086 OE1 GLN A 387 5.116 9.840 -25.663 1.00 96.27 O \\\\nATOM 3087 N THR A 388 7.585 6.039 -22.609 1.00 96.77 N \\\\nATOM 3088 CA THR A 388 7.359 4.769 -21.901 1.00 96.77 C \\\\nATOM 3089 C THR A 388 7.482 4.891 -20.379 1.00 96.77 C \\\\nATOM 3090 CB THR A 388 8.262 3.641 -22.424 1.00 96.77 C \\\\nATOM 3091 O THR A 388 8.281 5.683 -19.868 1.00 96.77 O \\\\nATOM 3092 CG2 THR A 388 8.328 3.568 -23.951 1.00 96.77 C \\\\nATOM 3093 OG1 THR A 388 9.576 3.812 -21.939 1.00 96.77 O \\\\nATOM 3094 N VAL A 389 6.756 4.048 -19.633 1.00 97.45 N \\\\nATOM 3095 CA VAL A 389 6.912 3.957 -18.167 1.00 97.45 C \\\\nATOM 3096 C VAL A 389 8.310 3.454 -17.785 1.00 97.45 C \\\\nATOM 3097 CB VAL A 389 5.801 3.086 -17.550 1.00 97.45 C \\\\nATOM 3098 O VAL A 389 8.912 3.944 -16.831 1.00 97.45 O \\\\nATOM 3099 CG1 VAL A 389 5.955 1.595 -17.873 1.00 97.45 C \\\\nATOM 3100 CG2 VAL A 389 5.724 3.294 -16.035 1.00 97.45 C \\\\nATOM 3101 N THR A 390 8.887 2.575 -18.610 1.00 97.99 N \\\\nATOM 3102 CA THR A 390 10.258 2.053 -18.489 1.00 97.99 C \\\\nATOM 3103 C THR A 390 11.346 3.119 -18.676 1.00 97.99 C \\\\nATOM 3104 CB THR A 390 10.484 0.908 -19.489 1.00 97.99 C \\\\nATOM 3105 O THR A 390 12.499 2.887 -18.328 1.00 97.99 O \\\\nATOM 3106 CG2 THR A 390 9.628 -0.312 -19.156 1.00 97.99 C \\\\nATOM 3107 OG1 THR A 390 10.131 1.299 -20.801 1.00 97.99 O \\\\nATOM 3108 N SER A 391 10.993 4.315 -19.163 1.00 97.57 N \\\\nATOM 3109 CA SER A 391 11.880 5.488 -19.190 1.00 97.57 C \\\\nATOM 3110 C SER A 391 11.865 6.287 -17.876 1.00 97.57 C \\\\nATOM 3111 CB SER A 391 11.491 6.413 -20.347 1.00 97.57 C \\\\nATOM 3112 O SER A 391 12.628 7.250 -17.716 1.00 97.57 O \\\\nATOM 3113 OG SER A 391 11.570 5.771 -21.600 1.00 97.57 O \\\\nATOM 3114 N THR A 392 10.972 5.959 -16.936 1.00 98.21 N \\\\nATOM 3115 CA THR A 392 10.876 6.643 -15.639 1.00 98.21 C \\\\nATOM 3116 C THR A 392 11.872 6.052 -14.631 1.00 98.21 C \\\\nATOM 3117 CB THR A 392 9.458 6.672 -15.051 1.00 98.21 C \\\\nATOM 3118 O THR A 392 12.089 4.840 -14.616 1.00 98.21 O \\\\nATOM 3119 CG2 THR A 392 8.388 7.194 -16.015 1.00 98.21 C \\\\nATOM 3120 OG1 THR A 392 9.084 5.412 -14.573 1.00 98.21 O \\\\nATOM 3121 N PRO A 393 12.518 6.866 -13.771 1.00 98.48 N \\\\nATOM 3122 CA PRO A 393 13.592 6.349 -12.921 1.00 98.48 C \\\\nATOM 3123 C PRO A 393 13.100 5.443 -11.783 1.00 98.48 C \\\\nATOM 3124 CB PRO A 393 14.326 7.582 -12.381 1.00 98.48 C \\\\nATOM 3125 O PRO A 393 13.865 4.617 -11.299 1.00 98.48 O \\\\nATOM 3126 CG PRO A 393 13.897 8.717 -13.306 1.00 98.48 C \\\\nATOM 3127 CD PRO A 393 12.477 8.318 -13.683 1.00 98.48 C \\\\nATOM 3128 N CYS A 394 11.856 5.613 -11.327 1.00 98.74 N \\\\nATOM 3129 CA CYS A 394 11.266 4.879 -10.207 1.00 98.74 C \\\\nATOM 3130 C CYS A 394 9.761 4.723 -10.431 1.00 98.74 C \\\\nATOM 3131 CB CYS A 394 11.484 5.670 -8.905 1.00 98.74 C \\\\nATOM 3132 O CYS A 394 9.036 5.719 -10.370 1.00 98.74 O \\\\nATOM 3133 SG CYS A 394 13.241 5.820 -8.497 1.00 98.74 S \\\\nATOM 3134 N TRP A 395 9.288 3.495 -10.619 1.00 98.82 N \\\\nATOM 3135 CA TRP A 395 7.864 3.208 -10.776 1.00 98.82 C \\\\nATOM 3136 C TRP A 395 7.477 1.861 -10.162 1.00 98.82 C \\\\nATOM 3137 CB TRP A 395 7.465 3.314 -12.257 1.00 98.82 C \\\\nATOM 3138 O TRP A 395 8.329 1.046 -9.813 1.00 98.82 O \\\\nATOM 3139 CG TRP A 395 8.092 2.330 -13.189 1.00 98.82 C \\\\nATOM 3140 CD1 TRP A 395 9.343 2.411 -13.690 1.00 98.82 C \\\\nATOM 3141 CD2 TRP A 395 7.504 1.123 -13.769 1.00 98.82 C \\\\nATOM 3142 CE2 TRP A 395 8.473 0.520 -14.624 1.00 98.82 C \\\\nATOM 3143 CE3 TRP A 395 6.250 0.480 -13.671 1.00 98.82 C \\\\nATOM 3144 NE1 TRP A 395 9.567 1.348 -14.535 1.00 98.82 N \\\\nATOM 3145 CH2 TRP A 395 6.985 -1.301 -15.179 1.00 98.82 C \\\\nATOM 3146 CZ2 TRP A 395 8.237 -0.677 -15.311 1.00 98.82 C \\\\nATOM 3147 CZ3 TRP A 395 5.993 -0.713 -14.374 1.00 98.82 C \\\\nATOM 3148 N ILE A 396 6.178 1.660 -9.978 1.00 98.81 N \\\\nATOM 3149 CA ILE A 396 5.573 0.439 -9.447 1.00 98.81 C \\\\nATOM 3150 C ILE A 396 4.464 -0.057 -10.370 1.00 98.81 C \\\\nATOM 3151 CB ILE A 396 5.055 0.618 -7.998 1.00 98.81 C \\\\nATOM 3152 O ILE A 396 3.745 0.736 -10.983 1.00 98.81 O \\\\nATOM 3153 CG1 ILE A 396 4.207 1.900 -7.835 1.00 98.81 C \\\\nATOM 3154 CG2 ILE A 396 6.250 0.602 -7.030 1.00 98.81 C \\\\nATOM 3155 CD1 ILE A 396 3.470 2.058 -6.498 1.00 98.81 C \\\\nATOM 3156 N GLU A 397 4.315 -1.374 -10.421 1.00 98.72 N \\\\nATOM 3157 CA GLU A 397 3.209 -2.078 -11.062 1.00 98.72 C \\\\nATOM 3158 C GLU A 397 2.344 -2.726 -9.976 1.00 98.72 C \\\\nATOM 3159 CB GLU A 397 3.781 -3.100 -12.056 1.00 98.72 C \\\\nATOM 3160 O GLU A 397 2.847 -3.509 -9.169 1.00 98.72 O \\\\nATOM 3161 CG GLU A 397 2.709 -3.684 -12.983 1.00 98.72 C \\\\nATOM 3162 CD GLU A 397 3.354 -4.370 -14.196 1.00 98.72 C \\\\nATOM 3163 OE1 GLU A 397 4.027 -5.404 -14.009 1.00 98.72 O \\\\nATOM 3164 OE2 GLU A 397 3.229 -3.803 -15.313 1.00 98.72 O \\\\nATOM 3165 N LEU A 398 1.064 -2.356 -9.931 1.00 98.36 N \\\\nATOM 3166 CA LEU A 398 0.030 -2.936 -9.076 1.00 98.36 C \\\\nATOM 3167 C LEU A 398 -0.766 -3.952 -9.890 1.00 98.36 C \\\\nATOM 3168 CB LEU A 398 -0.960 -1.852 -8.600 1.00 98.36 C \\\\nATOM 3169 O LEU A 398 -1.309 -3.596 -10.934 1.00 98.36 O \\\\nATOM 3170 CG LEU A 398 -0.604 -1.058 -7.342 1.00 98.36 C \\\\nATOM 3171 CD1 LEU A 398 0.694 -0.268 -7.468 1.00 98.36 C \\\\nATOM 3172 CD2 LEU A 398 -1.738 -0.065 -7.071 1.00 98.36 C \\\\nATOM 3173 N HIS A 399 -0.933 -5.157 -9.358 1.00 98.32 N \\\\nATOM 3174 CA HIS A 399 -1.912 -6.134 -9.832 1.00 98.32 C \\\\nATOM 3175 C HIS A 399 -3.045 -6.261 -8.817 1.00 98.32 C \\\\nATOM 3176 CB HIS A 399 -1.212 -7.476 -10.077 1.00 98.32 C \\\\nATOM 3177 O HIS A 399 -2.795 -6.535 -7.642 1.00 98.32 O \\\\nATOM 3178 CG HIS A 399 -0.309 -7.495 -11.284 1.00 98.32 C \\\\nATOM 3179 CD2 HIS A 399 -0.246 -6.557 -12.278 1.00 98.32 C \\\\nATOM 3180 ND1 HIS A 399 0.574 -8.494 -11.622 1.00 98.32 N \\\\nATOM 3181 CE1 HIS A 399 1.150 -8.160 -12.792 1.00 98.32 C \\\\nATOM 3182 NE2 HIS A 399 0.669 -6.989 -13.236 1.00 98.32 N \\\\nATOM 3183 N LEU A 400 -4.286 -6.050 -9.260 1.00 98.07 N \\\\nATOM 3184 CA LEU A 400 -5.481 -6.181 -8.426 1.00 98.07 C \\\\nATOM 3185 C LEU A 400 -5.967 -7.633 -8.445 1.00 98.07 C \\\\nATOM 3186 CB LEU A 400 -6.556 -5.184 -8.888 1.00 98.07 C \\\\nATOM 3187 O LEU A 400 -6.554 -8.105 -9.419 1.00 98.07 O \\\\nATOM 3188 CG LEU A 400 -6.121 -3.708 -8.840 1.00 98.07 C \\\\nATOM 3189 CD1 LEU A 400 -7.303 -2.837 -9.244 1.00 98.07 C \\\\nATOM 3190 CD2 LEU A 400 -5.657 -3.258 -7.451 1.00 98.07 C \\\\nATOM 3191 N ASN A 401 -5.706 -8.350 -7.354 1.00 97.27 N \\\\nATOM 3192 CA ASN A 401 -5.823 -9.807 -7.309 1.00 97.27 C \\\\nATOM 3193 C ASN A 401 -7.278 -10.291 -7.399 1.00 97.27 C \\\\nATOM 3194 CB ASN A 401 -5.159 -10.310 -6.019 1.00 97.27 C \\\\nATOM 3195 O ASN A 401 -7.529 -11.344 -7.975 1.00 97.27 O \\\\nATOM 3196 CG ASN A 401 -3.660 -10.068 -5.942 1.00 97.27 C \\\\nATOM 3197 ND2 ASN A 401 -3.127 -10.033 -4.747 1.00 97.27 N \\\\nATOM 3198 OD1 ASN A 401 -2.948 -9.899 -6.917 1.00 97.27 O \\\\nATOM 3199 N GLY A 402 -8.237 -9.532 -6.858 1.00 95.66 N \\\\nATOM 3200 CA GLY A 402 -9.663 -9.875 -6.913 1.00 95.66 C \\\\nATOM 3201 C GLY A 402 -10.217 -9.810 -8.341 1.00 95.66 C \\\\nATOM 3202 O GLY A 402 -10.705 -10.824 -8.843 1.00 95.66 O \\\\nATOM 3203 N PRO A 403 -10.083 -8.665 -9.040 1.00 96.62 N \\\\nATOM 3204 CA PRO A 403 -10.371 -8.549 -10.469 1.00 96.62 C \\\\nATOM 3205 C PRO A 403 -9.676 -9.615 -11.333 1.00 96.62 C \\\\nATOM 3206 CB PRO A 403 -9.945 -7.123 -10.839 1.00 96.62 C \\\\nATOM 3207 O PRO A 403 -10.339 -10.236 -12.160 1.00 96.62 O \\\\nATOM 3208 CG PRO A 403 -10.232 -6.348 -9.555 1.00 96.62 C \\\\nATOM 3209 CD PRO A 403 -9.818 -7.347 -8.476 1.00 96.62 C \\\\nATOM 3210 N LEU A 404 -8.385 -9.904 -11.099 1.00 96.80 N \\\\nATOM 3211 CA LEU A 404 -7.666 -10.983 -11.798 1.00 96.80 C \\\\nATOM 3212 C LEU A 404 -8.263 -12.371 -11.528 1.00 96.80 C \\\\nATOM 3213 CB LEU A 404 -6.174 -10.983 -11.410 1.00 96.80 C \\\\nATOM 3214 O LEU A 404 -8.483 -13.127 -12.468 1.00 96.80 O \\\\nATOM 3215 CG LEU A 404 -5.348 -9.857 -12.047 1.00 96.80 C \\\\nATOM 3216 CD1 LEU A 404 -3.952 -9.816 -11.431 1.00 96.80 C \\\\nATOM 3217 CD2 LEU A 404 -5.193 -10.022 -13.561 1.00 96.80 C \\\\nATOM 3218 N GLN A 405 -8.560 -12.711 -10.271 1.00 94.96 N \\\\nATOM 3219 CA GLN A 405 -9.154 -14.005 -9.921 1.00 94.96 C \\\\nATOM 3220 C GLN A 405 -10.559 -14.168 -10.515 1.00 94.96 C \\\\nATOM 3221 CB GLN A 405 -9.194 -14.155 -8.390 1.00 94.96 C \\\\nATOM 3222 O GLN A 405 -10.961 -15.273 -10.878 1.00 94.96 O \\\\nATOM 3223 CG GLN A 405 -9.640 -15.569 -7.985 1.00 94.96 C \\\\nATOM 3224 CD GLN A 405 -9.740 -15.779 -6.480 1.00 94.96 C \\\\nATOM 3225 NE2 GLN A 405 -9.435 -16.962 -5.997 1.00 94.96 N \\\\nATOM 3226 OE1 GLN A 405 -10.159 -14.935 -5.711 1.00 94.96 O \\\\nATOM 3227 N TRP A 406 -11.330 -13.084 -10.611 1.00 94.76 N \\\\nATOM 3228 CA TRP A 406 -12.641 -13.131 -11.250 1.00 94.76 C \\\\nATOM 3229 C TRP A 406 -12.522 -13.339 -12.760 1.00 94.76 C \\\\nATOM 3230 CB TRP A 406 -13.421 -11.861 -10.921 1.00 94.76 C \\\\nATOM 3231 O TRP A 406 -13.245 -14.162 -13.318 1.00 94.76 O \\\\nATOM 3232 CG TRP A 406 -14.901 -11.926 -11.139 1.00 94.76 C \\\\nATOM 3233 CD1 TRP A 406 -15.639 -13.020 -11.452 1.00 94.76 C \\\\nATOM 3234 CD2 TRP A 406 -15.853 -10.833 -11.027 1.00 94.76 C \\\\nATOM 3235 CE2 TRP A 406 -17.167 -11.362 -11.172 1.00 94.76 C \\\\nATOM 3236 CE3 TRP A 406 -15.734 -9.448 -10.788 1.00 94.76 C \\\\nATOM 3237 NE1 TRP A 406 -16.980 -12.692 -11.466 1.00 94.76 N \\\\nATOM 3238 CH2 TRP A 406 -18.161 -9.205 -10.753 1.00 94.76 C \\\\nATOM 3239 CZ2 TRP A 406 -18.308 -10.573 -11.020 1.00 94.76 C \\\\nATOM 3240 CZ3 TRP A 406 -16.875 -8.643 -10.643 1.00 94.76 C \\\\nATOM 3241 N LEU A 407 -11.569 -12.651 -13.393 1.00 95.07 N \\\\nATOM 3242 CA LEU A 407 -11.270 -12.788 -14.812 1.00 95.07 C \\\\nATOM 3243 C LEU A 407 -10.824 -14.213 -15.175 1.00 95.07 C \\\\nATOM 3244 CB LEU A 407 -10.192 -11.749 -15.164 1.00 95.07 C \\\\nATOM 3245 O LEU A 407 -11.353 -14.798 -16.115 1.00 95.07 O \\\\nATOM 3246 CG LEU A 407 -9.929 -11.642 -16.669 1.00 95.07 C \\\\nATOM 3247 CD1 LEU A 407 -11.149 -11.068 -17.375 1.00 95.07 C \\\\nATOM 3248 CD2 LEU A 407 -8.748 -10.715 -16.923 1.00 95.07 C \\\\nATOM 3249 N ASP A 408 -9.917 -14.797 -14.390 1.00 93.11 N \\\\nATOM 3250 CA ASP A 408 -9.437 -16.178 -14.539 1.00 93.11 C \\\\nATOM 3251 C ASP A 408 -10.587 -17.204 -14.477 1.00 93.11 C \\\\nATOM 3252 CB ASP A 408 -8.399 -16.419 -13.435 1.00 93.11 C \\\\nATOM 3253 O ASP A 408 -10.728 -18.059 -15.355 1.00 93.11 O \\\\nATOM 3254 CG ASP A 408 -7.860 -17.847 -13.445 1.00 93.11 C \\\\nATOM 3255 OD1 ASP A 408 -7.091 -18.163 -14.378 1.00 93.11 O \\\\nATOM 3256 OD2 ASP A 408 -8.220 -18.594 -12.507 1.00 93.11 O \\\\nATOM 3257 N LYS A 409 -11.502 -17.057 -13.508 1.00 92.52 N \\\\nATOM 3258 CA LYS A 409 -12.709 -17.897 -13.397 1.00 92.52 C \\\\nATOM 3259 C LYS A 409 -13.689 -17.758 -14.570 1.00 92.52 C \\\\nATOM 3260 CB LYS A 409 -13.466 -17.549 -12.121 1.00 92.52 C \\\\nATOM 3261 O LYS A 409 -14.478 -18.674 -14.795 1.00 92.52 O \\\\nATOM 3262 CG LYS A 409 -12.815 -18.012 -10.816 1.00 92.52 C \\\\nATOM 3263 CD LYS A 409 -13.636 -17.364 -9.697 1.00 92.52 C \\\\nATOM 3264 CE LYS A 409 -13.255 -17.844 -8.303 1.00 92.52 C \\\\nATOM 3265 NZ LYS A 409 -14.099 -17.132 -7.314 1.00 92.52 N \\\\nATOM 3266 N VAL A 410 -13.695 -16.619 -15.268 1.00 92.90 N \\\\nATOM 3267 CA VAL A 410 -14.493 -16.418 -16.489 1.00 92.90 C \\\\nATOM 3268 C VAL A 410 -13.777 -17.046 -17.685 1.00 92.90 C \\\\nATOM 3269 CB VAL A 410 -14.818 -14.925 -16.709 1.00 92.90 C \\\\nATOM 3270 O VAL A 410 -14.371 -17.866 -18.380 1.00 92.90 O \\\\nATOM 3271 CG1 VAL A 410 -15.438 -14.649 -18.082 1.00 92.90 C \\\\nATOM 3272 CG2 VAL A 410 -15.821 -14.432 -15.656 1.00 92.90 C \\\\nATOM 3273 N LEU A 411 -12.490 -16.743 -17.889 1.00 91.89 N \\\\nATOM 3274 CA LEU A 411 -11.679 -17.284 -18.988 1.00 91.89 C \\\\nATOM 3275 C LEU A 411 -11.652 -18.818 -18.994 1.00 91.89 C \\\\nATOM 3276 CB LEU A 411 -10.248 -16.723 -18.887 1.00 91.89 C \\\\nATOM 3277 O LEU A 411 -11.850 -19.428 -20.042 1.00 91.89 O \\\\nATOM 3278 CG LEU A 411 -10.117 -15.253 -19.320 1.00 91.89 C \\\\nATOM 3279 CD1 LEU A 411 -8.733 -14.724 -18.945 1.00 91.89 C \\\\nATOM 3280 CD2 LEU A 411 -10.290 -15.094 -20.834 1.00 91.89 C \\\\nATOM 3281 N THR A 412 -11.507 -19.444 -17.823 1.00 89.09 N \\\\nATOM 3282 CA THR A 412 -11.554 -20.911 -17.663 1.00 89.09 C \\\\nATOM 3283 C THR A 412 -12.888 -21.550 -18.070 1.00 89.09 C \\\\nATOM 3284 CB THR A 412 -11.218 -21.336 -16.222 1.00 89.09 C \\\\nATOM 3285 O THR A 412 -12.927 -22.757 -18.300 1.00 89.09 O \\\\nATOM 3286 CG2 THR A 412 -9.732 -21.190 -15.906 1.00 89.09 C \\\\nATOM 3287 OG1 THR A 412 -11.912 -20.558 -15.277 1.00 89.09 O \\\\nATOM 3288 N GLN A 413 -13.972 -20.775 -18.201 1.00 86.81 N \\\\nATOM 3289 CA GLN A 413 -15.280 -21.252 -18.672 1.00 86.81 C \\\\nATOM 3290 C GLN A 413 -15.551 -20.940 -20.153 1.00 86.81 C \\\\nATOM 3291 CB GLN A 413 -16.392 -20.705 -17.761 1.00 86.81 C \\\\nATOM 3292 O GLN A 413 -16.411 -21.583 -20.748 1.00 86.81 O \\\\nATOM 3293 CG GLN A 413 -16.258 -21.285 -16.347 1.00 86.81 C \\\\nATOM 3294 CD GLN A 413 -17.349 -20.835 -15.387 1.00 86.81 C \\\\nATOM 3295 NE2 GLN A 413 -17.067 -20.833 -14.103 1.00 86.81 N \\\\nATOM 3296 OE1 GLN A 413 -18.474 -20.520 -15.728 1.00 86.81 O \\\\nATOM 3297 N MET A 414 -14.802 -20.018 -20.773 1.00 85.54 N \\\\nATOM 3298 CA MET A 414 -14.980 -19.637 -22.185 1.00 85.54 C \\\\nATOM 3299 C MET A 414 -14.133 -20.455 -23.177 1.00 85.54 C \\\\nATOM 3300 CB MET A 414 -14.761 -18.132 -22.380 1.00 85.54 C \\\\nATOM 3301 O MET A 414 -14.115 -20.160 -24.369 1.00 85.54 O \\\\nATOM 3302 CG MET A 414 -15.737 -17.300 -21.541 1.00 85.54 C \\\\nATOM 3303 SD MET A 414 -15.963 -15.552 -21.980 1.00 85.54 S \\\\nATOM 3304 CE MET A 414 -14.405 -15.179 -22.806 1.00 85.54 C \\\\nATOM 3305 N GLY A 415 -13.432 -21.496 -22.723 1.00 82.14 N \\\\nATOM 3306 CA GLY A 415 -12.658 -22.373 -23.604 1.00 82.14 C \\\\nATOM 3307 C GLY A 415 -11.343 -21.744 -24.076 1.00 82.14 C \\\\nATOM 3308 O GLY A 415 -10.474 -21.450 -23.260 1.00 82.14 O \\\\nATOM 3309 N SER A 416 -11.159 -21.607 -25.392 1.00 81.44 N \\\\nATOM 3310 CA SER A 416 -9.897 -21.178 -26.015 1.00 81.44 C \\\\nATOM 3311 C SER A 416 -10.125 -20.213 -27.186 1.00 81.44 C \\\\nATOM 3312 CB SER A 416 -9.114 -22.408 -26.502 1.00 81.44 C \\\\nATOM 3313 O SER A 416 -11.213 -20.226 -27.766 1.00 81.44 O \\\\nATOM 3314 OG SER A 416 -9.784 -23.090 -27.551 1.00 81.44 O \\\\nATOM 3315 N PRO A 417 -9.103 -19.446 -27.618 1.00 82.09 N \\\\nATOM 3316 CA PRO A 417 -9.158 -18.678 -28.861 1.00 82.09 C \\\\nATOM 3317 C PRO A 417 -9.571 -19.530 -30.072 1.00 82.09 C \\\\nATOM 3318 CB PRO A 417 -7.753 -18.096 -29.059 1.00 82.09 C \\\\nATOM 3319 O PRO A 417 -9.239 -20.715 -30.158 1.00 82.09 O \\\\nATOM 3320 CG PRO A 417 -7.186 -18.034 -27.644 1.00 82.09 C \\\\nATOM 3321 CD PRO A 417 -7.814 -19.252 -26.967 1.00 82.09 C \\\\nATOM 3322 N SER A 418 -10.262 -18.910 -31.031 1.00 80.99 N \\\\nATOM 3323 CA SER A 418 -10.662 -19.545 -32.296 1.00 80.99 C \\\\nATOM 3324 C SER A 418 -9.466 -19.816 -33.218 1.00 80.99 C \\\\nATOM 3325 CB SER A 418 -11.680 -18.649 -33.011 1.00 80.99 C \\\\nATOM 3326 O SER A 418 -9.413 -20.846 -33.893 1.00 80.99 O \\\\nATOM 3327 OG SER A 418 -11.172 -17.331 -33.132 1.00 80.99 O \\\\nATOM 3328 N ILE A 419 -8.483 -18.912 -33.221 1.00 81.26 N \\\\nATOM 3329 CA ILE A 419 -7.231 -19.055 -33.965 1.00 81.26 C \\\\nATOM 3330 C ILE A 419 -6.295 -19.973 -33.174 1.00 81.26 C \\\\nATOM 3331 CB ILE A 419 -6.594 -17.676 -34.263 1.00 81.26 C \\\\nATOM 3332 O ILE A 419 -5.882 -19.659 -32.058 1.00 81.26 O \\\\nATOM 3333 CG1 ILE A 419 -7.578 -16.783 -35.058 1.00 81.26 C \\\\nATOM 3334 CG2 ILE A 419 -5.278 -17.863 -35.045 1.00 81.26 C \\\\nATOM 3335 CD1 ILE A 419 -7.081 -15.352 -35.301 1.00 81.26 C \\\\nATOM 3336 N ARG A 420 -5.929 -21.114 -33.767 1.00 83.97 N \\\\nATOM 3337 CA ARG A 420 -4.920 -22.014 -33.193 1.00 83.97 C \\\\nATOM 3338 C ARG A 420 -3.526 -21.423 -33.385 1.00 83.97 C \\\\nATOM 3339 CB ARG A 420 -5.003 -23.414 -33.814 1.00 83.97 C \\\\nATOM 3340 O ARG A 420 -3.164 -21.055 -34.499 1.00 83.97 O \\\\nATOM 3341 CG ARG A 420 -6.335 -24.106 -33.502 1.00 83.97 C \\\\nATOM 3342 CD ARG A 420 -6.312 -25.543 -34.028 1.00 83.97 C \\\\nATOM 3343 NE ARG A 420 -7.597 -26.219 -33.779 1.00 83.97 N \\\\nATOM 3344 NH1 ARG A 420 -6.954 -28.339 -34.384 1.00 83.97 N \\\\nATOM 3345 NH2 ARG A 420 -9.053 -27.965 -33.716 1.00 83.97 N \\\\nATOM 3346 CZ ARG A 420 -7.860 -27.500 -33.960 1.00 83.97 C \\\\nATOM 3347 N CYS A 421 -2.733 -21.398 -32.318 1.00 83.68 N \\\\nATOM 3348 CA CYS A 421 -1.320 -21.044 -32.406 1.00 83.68 C \\\\nATOM 3349 C CYS A 421 -0.531 -22.142 -33.143 1.00 83.68 C \\\\nATOM 3350 CB CYS A 421 -0.786 -20.779 -30.993 1.00 83.68 C \\\\nATOM 3351 O CYS A 421 -0.792 -23.334 -32.955 1.00 83.68 O \\\\nATOM 3352 SG CYS A 421 0.817 -19.947 -31.129 1.00 83.68 S \\\\nATOM 3353 N SER A 422 0.433 -21.746 -33.976 1.00 85.93 N \\\\nATOM 3354 CA SER A 422 1.379 -22.670 -34.607 1.00 85.93 C \\\\nATOM 3355 C SER A 422 2.461 -23.078 -33.607 1.00 85.93 C \\\\nATOM 3356 CB SER A 422 2.006 -22.014 -35.839 1.00 85.93 C \\\\nATOM 3357 O SER A 422 2.934 -22.264 -32.823 1.00 85.93 O \\\\nATOM 3358 OG SER A 422 3.003 -22.843 -36.411 1.00 85.93 O \\\\nATOM 3359 N SER A 423 2.904 -24.335 -33.658 1.00 89.58 N \\\\nATOM 3360 CA SER A 423 4.051 -24.816 -32.874 1.00 89.58 C \\\\nATOM 3361 C SER A 423 5.402 -24.609 -33.580 1.00 89.58 C \\\\nATOM 3362 CB SER A 423 3.834 -26.286 -32.505 1.00 89.58 C \\\\nATOM 3363 O SER A 423 6.389 -25.223 -33.179 1.00 89.58 O \\\\nATOM 3364 OG SER A 423 3.847 -27.096 -33.667 1.00 89.58 O \\\\nATOM 3365 N VAL A 424 5.430 -23.853 -34.686 1.00 86.04 N \\\\nATOM 3366 CA VAL A 424 6.582 -23.732 -35.608 1.00 86.04 C \\\\nATOM 3367 C VAL A 424 6.860 -22.279 -36.040 1.00 86.04 C \\\\nATOM 3368 CB VAL A 424 6.367 -24.626 -36.861 1.00 86.04 C \\\\nATOM 3369 O VAL A 424 7.895 -22.021 -36.645 1.00 86.04 O \\\\nATOM 3370 CG1 VAL A 424 7.640 -24.833 -37.700 1.00 86.04 C \\\\nATOM 3371 CG2 VAL A 424 5.872 -26.041 -36.507 1.00 86.04 C \\\\nATOM 3372 N SER A 425 5.935 -21.348 -35.773 1.00 67.52 N \\\\nATOM 3373 CA SER A 425 6.045 -19.920 -36.132 1.00 67.52 C \\\\nATOM 3374 C SER A 425 7.004 -19.152 -35.232 1.00 67.52 C \\\\nATOM 3375 CB SER A 425 4.678 -19.249 -36.048 1.00 67.52 C \\\\nATOM 3376 O SER A 425 6.854 -19.333 -34.002 1.00 67.52 O \\\\nATOM 3377 OG SER A 425 4.186 -19.498 -34.749 1.00 67.52 O \\\\nATOM 3378 OXT SER A 425 7.754 -18.328 -35.788 1.00 67.52 O \\\\nTER 3379 SER A 425 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 9, 'score': 0}, {'residue_no': 10, 'score': 0}, {'residue_no': 11, 'score': 0}, {'residue_no': 12, 'score': 0}, {'residue_no': 13, 'score': 0}, {'residue_no': 14, 'score': 0}, {'residue_no': 15, 'score': 0}, {'residue_no': 16, 'score': 0}, {'residue_no': 17, 'score': 0}, {'residue_no': 18, 'score': 0}, {'residue_no': 19, 'score': 0}, {'residue_no': 20, 'score': 0}, {'residue_no': 21, 'score': 0}, {'residue_no': 22, 'score': 0}, {'residue_no': 23, 'score': 0}, {'residue_no': 24, 'score': 0}, {'residue_no': 25, 'score': 0}, {'residue_no': 26, 'score': 0}, {'residue_no': 27, 'score': 0}, {'residue_no': 28, 'score': 0}, {'residue_no': 29, 'score': 0}, {'residue_no': 30, 'score': 0}, {'residue_no': 31, 'score': 0}, {'residue_no': 32, 'score': 0}, {'residue_no': 33, 'score': 0}, {'residue_no': 34, 'score': 0}, {'residue_no': 35, 'score': 0}, {'residue_no': 36, 'score': 0}, {'residue_no': 37, 'score': 0}, {'residue_no': 38, 'score': 0}, {'residue_no': 39, 'score': 0}, {'residue_no': 40, 'score': 0}, {'residue_no': 41, 'score': 0}, {'residue_no': 42, 'score': 0}, {'residue_no': 43, 'score': 0}, {'residue_no': 44, 'score': 0}, {'residue_no': 45, 'score': 0}, {'residue_no': 46, 'score': 0}, {'residue_no': 47, 'score': 0}, {'residue_no': 48, 'score': 0}, {'residue_no': 49, 'score': 0}, {'residue_no': 50, 'score': 0}, {'residue_no': 51, 'score': 0}, {'residue_no': 52, 'score': 0}, {'residue_no': 53, 'score': 0}, {'residue_no': 54, 'score': 0}, {'residue_no': 55, 'score': 0}, {'residue_no': 56, 'score': 0}, {'residue_no': 57, 'score': 0}, {'residue_no': 58, 'score': 0}, {'residue_no': 59, 'score': 0}, {'residue_no': 60, 'score': 0}, {'residue_no': 61, 'score': 0}, {'residue_no': 62, 'score': 0}, {'residue_no': 63, 'score': 0}, {'residue_no': 64, 'score': 0}, {'residue_no': 65, 'score': 0}, {'residue_no': 66, 'score': 0}, {'residue_no': 67, 'score': 0}, {'residue_no': 68, 'score': 0}, {'residue_no': 69, 'score': 0}, {'residue_no': 70, 'score': 0}, {'residue_no': 71, 'score': 0}, {'residue_no': 72, 'score': 0}, {'residue_no': 73, 'score': 0}, {'residue_no': 74, 'score': 0}, {'residue_no': 75, 'score': 0}, {'residue_no': 76, 'score': 0}, {'residue_no': 77, 'score': 0}, {'residue_no': 78, 'score': 0}, {'residue_no': 79, 'score': 0}, {'residue_no': 80, 'score': 0}, {'residue_no': 81, 'score': 0}, {'residue_no': 82, 'score': 0}, {'residue_no': 83, 'score': 0}, {'residue_no': 84, 'score': 0}, {'residue_no': 85, 'score': 0}, {'residue_no': 86, 'score': 0}, {'residue_no': 87, 'score': 0}, {'residue_no': 88, 'score': 0}, {'residue_no': 89, 'score': 0}, {'residue_no': 90, 'score': 0}, {'residue_no': 91, 'score': 0}, {'residue_no': 92, 'score': 0}, {'residue_no': 93, 'score': 0}, {'residue_no': 94, 'score': 0}, {'residue_no': 95, 'score': 0}, {'residue_no': 96, 'score': 0}, {'residue_no': 97, 'score': 0}, {'residue_no': 98, 'score': 0}, {'residue_no': 99, 'score': 0}, {'residue_no': 100, 'score': 0}, {'residue_no': 101, 'score': 0}, {'residue_no': 102, 'score': 0}, {'residue_no': 103, 'score': 0}, {'residue_no': 104, 'score': 0}, {'residue_no': 105, 'score': 0}, {'residue_no': 106, 'score': 0}, {'residue_no': 107, 'score': 0}, {'residue_no': 108, 'score': 0}, {'residue_no': 109, 'score': 0}, {'residue_no': 110, 'score': 0}, {'residue_no': 111, 'score': 0}, {'residue_no': 112, 'score': 0}, {'residue_no': 113, 'score': 0}, {'residue_no': 114, 'score': 0}, {'residue_no': 115, 'score': 0}, {'residue_no': 116, 'score': 0}, {'residue_no': 117, 'score': 0}, {'residue_no': 118, 'score': 0}, {'residue_no': 119, 'score': 0}, {'residue_no': 120, 'score': 0}, {'residue_no': 121, 'score': 0}, {'residue_no': 122, 'score': 0}, {'residue_no': 123, 'score': 0}, {'residue_no': 124, 'score': 0}, {'residue_no': 125, 'score': 0}, {'residue_no': 126, 'score': 0}, {'residue_no': 127, 'score': 0}, {'residue_no': 128, 'score': 0}, {'residue_no': 129, 'score': 0}, {'residue_no': 130, 'score': 0}, {'residue_no': 131, 'score': 0}, {'residue_no': 132, 'score': 0}, {'residue_no': 133, 'score': 0}, {'residue_no': 134, 'score': 0}, {'residue_no': 135, 'score': 0}, {'residue_no': 136, 'score': 0}, {'residue_no': 137, 'score': 0}, {'residue_no': 138, 'score': 0}, {'residue_no': 139, 'score': 0}, {'residue_no': 140, 'score': 0}, {'residue_no': 141, 'score': 0}, {'residue_no': 142, 'score': 0}, {'residue_no': 143, 'score': 0}, {'residue_no': 144, 'score': 0}, {'residue_no': 145, 'score': 0}, {'residue_no': 146, 'score': 0}, {'residue_no': 147, 'score': 0}, {'residue_no': 148, 'score': 0}, {'residue_no': 149, 'score': 0}, {'residue_no': 150, 'score': 0}, {'residue_no': 151, 'score': 0}, {'residue_no': 152, 'score': 0}, {'residue_no': 153, 'score': 0}, {'residue_no': 154, 'score': 0}, {'residue_no': 155, 'score': 0}, {'residue_no': 156, 'score': 0}, {'residue_no': 157, 'score': 0}, {'residue_no': 158, 'score': 0}, {'residue_no': 159, 'score': 0}, {'residue_no': 160, 'score': 0}, {'residue_no': 161, 'score': 0}, {'residue_no': 162, 'score': 0}, 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'P84022_C394', 'P84022_C421'], 'hyperreactive_residues': [], 'ligandable_residues': [], 'is_act_site_residues': [], 'near_act_site_residues': [], 'is_bind_site_residues': ['P84022_C64', 'P84022_C109', 'P84022_C121'], 'near_bind_site_residues': [], 'near_act_site_neighbors': [], 'near_bind_site_neighbors': [], 'near_act_site_neighbors_per_residue': {}, 'near_bind_site_neighbors_per_residue': {}, 'has_any_flag': True, 'include_cysdb': True}}, 'labels': {1: 'MET1', 2: 'SER2', 3: 'SER3', 4: 'ILE4', 5: 'LEU5', 6: 'PRO6', 7: 'PHE7', 8: 'THR8', 9: 'PRO9', 10: 'PRO10', 11: 'ILE11', 12: 'VAL12', 13: 'LYS13', 14: 'ARG14', 15: 'LEU15', 16: 'LEU16', 17: 'GLY17', 18: 'TRP18', 19: 'LYS19', 20: 'LYS20', 21: 'GLY21', 22: 'GLU22', 23: 'GLN23', 24: 'ASN24', 25: 'GLY25', 26: 'GLN26', 27: 'GLU27', 28: 'GLU28', 29: 'LYS29', 30: 'TRP30', 31: 'CYS31', 32: 'GLU32', 33: 'LYS33', 34: 'ALA34', 35: 'VAL35', 36: 'LYS36', 37: 'SER37', 38: 'LEU38', 39: 'VAL39', 40: 'LYS40', 41: 'LYS41', 42: 'LEU42', 43: 'LYS43', 44: 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'ASP118', 119: 'GLU119', 120: 'VAL120', 121: 'CYS121', 122: 'VAL122', 123: 'ASN123', 124: 'PRO124', 125: 'TYR125', 126: 'HIS126', 127: 'TYR127', 128: 'GLN128', 129: 'ARG129', 130: 'VAL130', 131: 'GLU131', 132: 'THR132', 133: 'PRO133', 134: 'VAL134', 135: 'LEU135', 136: 'PRO136', 137: 'PRO137', 138: 'VAL138', 139: 'LEU139', 140: 'VAL140', 141: 'PRO141', 142: 'ARG142', 143: 'HIS143', 144: 'THR144', 145: 'GLU145', 146: 'ILE146', 147: 'PRO147', 148: 'ALA148', 149: 'GLU149', 150: 'PHE150', 151: 'PRO151', 152: 'PRO152', 153: 'LEU153', 154: 'ASP154', 155: 'ASP155', 156: 'TYR156', 157: 'SER157', 158: 'HIS158', 159: 'SER159', 160: 'ILE160', 161: 'PRO161', 162: 'GLU162', 163: 'ASN163', 164: 'THR164', 165: 'ASN165', 166: 'PHE166', 167: 'PRO167', 168: 'ALA168', 169: 'GLY169', 170: 'ILE170', 171: 'GLU171', 172: 'PRO172', 173: 'GLN173', 174: 'SER174', 175: 'ASN175', 176: 'ILE176', 177: 'PRO177', 178: 'GLU178', 179: 'THR179', 180: 'PRO180', 181: 'PRO181', 182: 'PRO182', 183: 'GLY183', 184: 'TYR184', 185: 'LEU185', 186: 'SER186', 187: 'GLU187', 188: 'ASP188', 189: 'GLY189', 190: 'GLU190', 191: 'THR191', 192: 'SER192', 193: 'ASP193', 194: 'HIS194', 195: 'GLN195', 196: 'MET196', 197: 'ASN197', 198: 'HIS198', 199: 'SER199', 200: 'MET200', 201: 'ASP201', 202: 'ALA202', 203: 'GLY203', 204: 'SER204', 205: 'PRO205', 206: 'ASN206', 207: 'LEU207', 208: 'SER208', 209: 'PRO209', 210: 'ASN210', 211: 'PRO211', 212: 'MET212', 213: 'SER213', 214: 'PRO214', 215: 'ALA215', 216: 'HIS216', 217: 'ASN217', 218: 'ASN218', 219: 'LEU219', 220: 'ASP220', 221: 'LEU221', 222: 'GLN222', 223: 'PRO223', 224: 'VAL224', 225: 'THR225', 226: 'TYR226', 227: 'CYS227', 228: 'GLU228', 229: 'PRO229', 230: 'ALA230', 231: 'PHE231', 232: 'TRP232', 233: 'CYS233', 234: 'SER234', 235: 'ILE235', 236: 'SER236', 237: 'TYR237', 238: 'TYR238', 239: 'GLU239', 240: 'LEU240', 241: 'ASN241', 242: 'GLN242', 243: 'ARG243', 244: 'VAL244', 245: 'GLY245', 246: 'GLU246', 247: 'THR247', 248: 'PHE248', 249: 'HIS249', 250: 'ALA250', 251: 'SER251', 252: 'GLN252', 253: 'PRO253', 254: 'SER254', 255: 'MET255', 256: 'THR256', 257: 'VAL257', 258: 'ASP258', 259: 'GLY259', 260: 'PHE260', 261: 'THR261', 262: 'ASP262', 263: 'PRO263', 264: 'SER264', 265: 'ASN265', 266: 'SER266', 267: 'GLU267', 268: 'ARG268', 269: 'PHE269', 270: 'CYS270', 271: 'LEU271', 272: 'GLY272', 273: 'LEU273', 274: 'LEU274', 275: 'SER275', 276: 'ASN276', 277: 'VAL277', 278: 'ASN278', 279: 'ARG279', 280: 'ASN280', 281: 'ALA281', 282: 'ALA282', 283: 'VAL283', 284: 'GLU284', 285: 'LEU285', 286: 'THR286', 287: 'ARG287', 288: 'ARG288', 289: 'HIS289', 290: 'ILE290', 291: 'GLY291', 292: 'ARG292', 293: 'GLY293', 294: 'VAL294', 295: 'ARG295', 296: 'LEU296', 297: 'TYR297', 298: 'TYR298', 299: 'ILE299', 300: 'GLY300', 301: 'GLY301', 302: 'GLU302', 303: 'VAL303', 304: 'PHE304', 305: 'ALA305', 306: 'GLU306', 307: 'CYS307', 308: 'LEU308', 309: 'SER309', 310: 'ASP310', 311: 'SER311', 312: 'ALA312', 313: 'ILE313', 314: 'PHE314', 315: 'VAL315', 316: 'GLN316', 317: 'SER317', 318: 'PRO318', 319: 'ASN319', 320: 'CYS320', 321: 'ASN321', 322: 'GLN322', 323: 'ARG323', 324: 'TYR324', 325: 'GLY325', 326: 'TRP326', 327: 'HIS327', 328: 'PRO328', 329: 'ALA329', 330: 'THR330', 331: 'VAL331', 332: 'CYS332', 333: 'LYS333', 334: 'ILE334', 335: 'PRO335', 336: 'PRO336', 337: 'GLY337', 338: 'CYS338', 339: 'ASN339', 340: 'LEU340', 341: 'LYS341', 342: 'ILE342', 343: 'PHE343', 344: 'ASN344', 345: 'ASN345', 346: 'GLN346', 347: 'GLU347', 348: 'PHE348', 349: 'ALA349', 350: 'ALA350', 351: 'LEU351', 352: 'LEU352', 353: 'ALA353', 354: 'GLN354', 355: 'SER355', 356: 'VAL356', 357: 'ASN357', 358: 'GLN358', 359: 'GLY359', 360: 'PHE360', 361: 'GLU361', 362: 'ALA362', 363: 'VAL363', 364: 'TYR364', 365: 'GLN365', 366: 'LEU366', 367: 'THR367', 368: 'ARG368', 369: 'MET369', 370: 'CYS370', 371: 'THR371', 372: 'ILE372', 373: 'ARG373', 374: 'MET374', 375: 'SER375', 376: 'PHE376', 377: 'VAL377', 378: 'LYS378', 379: 'GLY379', 380: 'TRP380', 381: 'GLY381', 382: 'ALA382', 383: 'GLU383', 384: 'TYR384', 385: 'ARG385', 386: 'ARG386', 387: 'GLN387', 388: 'THR388', 389: 'VAL389', 390: 'THR390', 391: 'SER391', 392: 'THR392', 393: 'PRO393', 394: 'CYS394', 395: 'TRP395', 396: 'ILE396', 397: 'GLU397', 398: 'LEU398', 399: 'HIS399', 400: 'LEU400', 401: 'ASN401', 402: 'GLY402', 403: 'PRO403', 404: 'LEU404', 405: 'GLN405', 406: 'TRP406', 407: 'LEU407', 408: 'ASP408', 409: 'LYS409', 410: 'VAL410', 411: 'LEU411', 412: 'THR412', 413: 'GLN413', 414: 'MET414', 415: 'GLY415', 416: 'SER416', 417: 'PRO417', 418: 'SER418', 419: 'ILE419', 420: 'ARG420', 421: 'CYS421', 422: 'SER422', 423: 'SER423', 424: 'VAL424', 425: 'SER425'}}}}\\n[TOOL RUN] → uniprot_base\\nFetching UniProt entries for 2 genes: ['SMAD2', 'SMAD3']\\nFetching UniProt entry for gene: SMAD2\\nUNIPROT RESULTS [{'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'Q15796', 'uniProtkbId': 'SMAD2_HUMAN', 'entryAudit': {'firstPublicDate': '2001-04-27', 'lastAnnotationUpdateDate': '2025-06-18', 'lastSequenceUpdateDate': '1996-11-01', 'entryVersion': 253, 'sequenceVersion': 1}, 'annotationScore': 5.0, 'organism': {'scientificName': 'Homo sapiens', 'commonName': 'Human', 'taxonId': 9606, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Mothers against decapentaplegic homolog 2'}, 'shortNames': [{'value': 'MAD homolog 2'}, {'value': 'Mothers against DPP homolog 2'}]}, 'alternativeNames': [{'fullName': {'value': 'JV18-1'}}, {'fullName': {'value': 'Mad-related protein 2'}, 'shortNames': [{'value': 'hMAD-2'}]}, {'fullName': {'value': 'SMAD family member 2'}, 'shortNames': [{'value': 'SMAD 2'}, {'value': 'Smad2'}, {'value': 'hSMAD2'}]}]}, 'genes': [{'geneName': {'value': 'SMAD2'}, 'synonyms': [{'value': 'MADH2'}, {'value': 'MADR2'}]}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': 'Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209)'}], 'commentType': 'FUNCTION'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10615055'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10835638'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11278756'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11387212'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11389444'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15350224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15647271'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16200078'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751102'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17099224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17292623'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18568018'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19049980'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24324267'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24627487'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25105025'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9670020'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9702198'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}, {'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '20061380'}], 'value': \\\"Monomer; in the absence of TGF-beta (PubMed:9670020). Heterodimer; in the presence of TGF-beta (PubMed:9670020). Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4 (PubMed:15350224, PubMed:24324267, PubMed:9670020). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta (PubMed:16751102). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (PubMed:24324267). Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD (PubMed:10615055). Interacts with TAZ/WWRT1 (PubMed:18568018). Interacts with FOXH1 (PubMed:9702198). Interacts with SNW1 (PubMed:11278756). Interacts with CREB-binding protein (CBP) and EP300 (PubMed:16862174). Interacts with SNON (PubMed:11389444). Interacts with ALK4/ACVR1B (PubMed:10615055, PubMed:9892009). Interacts with SKOR1 (PubMed:17292623). Interacts with SKOR2 (PubMed:16200078). Interacts with PRDM16 (PubMed:19049980). Interacts (via MH2 domain) with LEMD3 (PubMed:15601644, PubMed:15647271). Interacts with RBPMS (PubMed:17099224). Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (PubMed:19289081). Interacts with PDPK1 (via PH domain) (PubMed:17327236). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (PubMed:11387212). Interacts with USP15 (PubMed:21947082). Interacts with PPP5C (PubMed:22781750). Interacts with LDLRAD4 (via the SMAD interaction motif) (PubMed:24627487). Interacts (via MH2 domain) with PMEPA1 (via the SMAD interaction motif) (PubMed:20129061). Interacts with ZFHX3 (PubMed:25105025). Interacts with ZNF451 (PubMed:24324267). Interacts with SMURF2 when phosphorylated on Ser-465/467 (PubMed:11389444). Interacts with PPM1A (PubMed:16751101). Interacts with TGF-beta (PubMed:8980228). Interacts with TGFBR1 (PubMed:9865696). Interacts with TGIF (PubMed:10835638). Interacts with SMAD3 and TRIM33 (PubMed:16751102). Interacts with ZNF580 (PubMed:21599657). Interacts with NEDD4L in response to TGF-beta (By similarity). Interacts with HGS (By similarity). Interacts with AIP1 (By similarity). Interacts with WWP1 (By similarity). Interacts with PML (By similarity). Interacts weakly with ZNF8 (By similarity). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD2 inhibitors (By similarity). Interacts with YAP1 (when phosphorylated at 'Ser-127') (By similarity). Interacts when phosphorylated with IPO7; the interaction facilitates translocation of SMAD2 to the nucleus (By similarity). Interacts with MTMR4; negatively regulates TGF-beta signaling through SMAD2 dephosphorylation and retention in endosomes (Probable)\\\"}], 'commentType': 'SUBUNIT'}, {'commentType': 'INTERACTION', 'interactions': [{'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q12955', 'geneName': 'ANK3', 'intActId': 'EBI-2691178'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P05060', 'geneName': 'CHGB', 'intActId': 'EBI-712619'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O15111', 'geneName': 'CHUK', 'intActId': 'EBI-81249'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P98082', 'geneName': 'DAB2', 'intActId': 'EBI-1171238'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZ29', 'geneName': 'DOCK9', 'intActId': 'EBI-2695893'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O75593', 'geneName': 'FOXH1', 'intActId': 'EBI-1759806'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P05412', 'geneName': 'JUN', 'intActId': 'EBI-852823'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9NYA4', 'geneName': 'MTMR4', 'intActId': 'EBI-1052346'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P07197', 'geneName': 'NEFM', 'intActId': 'EBI-1105035'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q8TAK6', 'geneName': 'OLIG1', 'intActId': 'EBI-3867416'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P35813', 'geneName': 'PPM1A', 'intActId': 'EBI-989143'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H6Z4', 'geneName': 'RANBP3', 'intActId': 'EBI-992681'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P61586', 'geneName': 'RHOA', 'intActId': 'EBI-446668'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P12755', 'geneName': 'SKI', 'intActId': 'EBI-347281'}, 'numberOfExperiments': 11, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P12757', 'geneName': 'SKIL', 'intActId': 'EBI-2902468'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q15796', 'geneName': 'SMAD2', 'intActId': 'EBI-1040141'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P84022', 'geneName': 'SMAD3', 'intActId': 'EBI-347161'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q13485', 'geneName': 'SMAD4', 'intActId': 'EBI-347263'}, 'numberOfExperiments': 24, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9HAU4', 'geneName': 'SMURF2', 'intActId': 'EBI-396727'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q13573', 'geneName': 'SNW1', 'intActId': 'EBI-632715'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P04637', 'geneName': 'TP53', 'intActId': 'EBI-366083'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H3D4', 'geneName': 'TP63', 'intActId': 'EBI-2337775'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9UPN9', 'geneName': 'TRIM33', 'intActId': 'EBI-2214398'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O00308', 'geneName': 'WWP2', 'intActId': 'EBI-743923'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q96KR1', 'geneName': 'ZFR', 'intActId': 'EBI-2513582'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O95405', 'geneName': 'ZFYVE9', 'intActId': 'EBI-296817'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P70056', 'geneName': 'foxh1', 'intActId': 'EBI-9969973'}, 'numberOfExperiments': 4, 'organismDiffer': True}]}, {'commentType': 'SUBCELLULAR LOCATION', 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 (PubMed:21145499, PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)'}]}, 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Cytoplasm', 'id': 'SL-0086'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Nucleus', 'id': 'SL-0191'}}]}, {'commentType': 'ALTERNATIVE PRODUCTS', 'events': ['Alternative splicing'], 'isoforms': [{'name': {'value': 'Long'}, 'isoformIds': ['Q15796-1'], 'isoformSequenceStatus': 'Displayed'}, {'name': {'value': 'Short'}, 'synonyms': [{'value': 'Smad2Deltaexon3'}], 'isoformIds': ['Q15796-2'], 'sequenceIds': ['VSP_006178'], 'isoformSequenceStatus': 'Described'}]}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}], 'value': 'Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta'}], 'commentType': 'TISSUE SPECIFICITY'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11879191'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12193595'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}], 'value': 'Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'value': \\\"In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding (By similarity). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover (By similarity)\\\"}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}], 'value': 'Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. Isoform short: Acetylation increases DNA binding activity in vitro and enhances its association with target promoters in vivo. Acetylation in the nucleus by EP300 is enhanced by TGF-beta'}], 'commentType': 'PTM'}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Congenital heart defects, multiple types, 8, with or without heterotaxy', 'diseaseAccession': 'DI-06292', 'acronym': 'CHTD8', 'description': 'An autosomal dominant disorder characterized by congenital developmental abnormalities involving structures of the heart. Common CHTD8 features include double-outlet right ventricle, unbalanced complete atrioventricular canal, and valvular anomalies. Vascular anomalies include dextroposition of the great arteries, anomalous pulmonary venous return, and superior vena cava to left atrium defect. Patients may also exhibit laterality defects, including dextrocardia, atrial isomerism, dextrogastria, left-sided gallbladder, and intestinal malrotation.', 'diseaseCrossReference': {'database': 'MIM', 'id': '619657'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23665959'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Loeys-Dietz syndrome 6', 'diseaseAccession': 'DI-06280', 'acronym': 'LDS6', 'description': 'A form of Loeys-Dietz syndrome, a syndrome with widespread systemic involvement characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Most LDS6 patients have thoracic aortic aneurysm involving the ascending aorta and/or aortic root, but cerebral and iliac arteries can be affected, and abdominal aortic aneurysm has been observed. Arterial tortuosity involving cerebral vessels, the aorta, and/or iliac arteries has also been reported. LDS6 inheritance is autosomal dominant.', 'diseaseCrossReference': {'database': 'MIM', 'id': '619656'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28283438'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Belongs to the dwarfin/SMAD family'}], 'commentType': 'SIMILARITY'}, {'commentType': 'WEB RESOURCE', 'resourceName': 'Atlas of Genetics and Cytogenetics in Oncology and Haematology', 'resourceUrl': 'https://atlasgeneticsoncology.org/gene/370/SMAD2', 'ftp': False}], 'features': [{'type': 'Initiator methionine', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 1, 'modifier': 'EXACT'}}, 'description': 'Removed', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22223895'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Chain', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Mothers against decapentaplegic homolog 2', 'featureId': 'PRO_0000090852'}, {'type': 'Domain', 'location': {'start': {'value': 10, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'MH1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00438'}]}, {'type': 'Domain', 'location': {'start': {'value': 274, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'MH2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Region', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Motif', 'location': {'start': {'value': 221, 'modifier': 'EXACT'}, 'end': {'value': 225, 'modifier': 'EXACT'}}, 'description': 'PY-motif'}, {'type': 'Compositional bias', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 217, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Compositional bias', 'location': {'start': {'value': 233, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Binding site', 'location': {'start': {'value': 74, 'modifier': 'EXACT'}, 'end': {'value': 74, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 149, 'modifier': 'EXACT'}, 'end': {'value': 149, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 161, 'modifier': 'EXACT'}, 'end': {'value': 161, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 166, 'modifier': 'EXACT'}, 'end': {'value': 166, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Modified residue', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 2, 'modifier': 'EXACT'}}, 'description': 'N-acetylserine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22223895'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by MAPK3', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12193595'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18691976'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 19, 'modifier': 'EXACT'}, 'end': {'value': 19, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 220, 'modifier': 'EXACT'}, 'end': {'value': 220, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 240, 'modifier': 'EXACT'}, 'end': {'value': 240, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CAMK2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11879191'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 255, 'modifier': 'EXACT'}, 'end': {'value': 255, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 458, 'modifier': 'EXACT'}, 'end': {'value': 458, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18669648'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 460, 'modifier': 'EXACT'}, 'end': {'value': 460, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 464, 'modifier': 'EXACT'}, 'end': {'value': 464, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}]}, {'type': 'Alternative sequence', 'location': {'start': {'value': 79, 'modifier': 'EXACT'}, 'end': {'value': 108, 'modifier': 'EXACT'}}, 'description': 'in isoform Short', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'featureId': 'VSP_006178', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 133, 'modifier': 'EXACT'}, 'end': {'value': 133, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011375', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 159, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}], 'featureId': 'VAR_086573', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 274, 'modifier': 'EXACT'}, 'end': {'value': 274, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23665959'}], 'featureId': 'VAR_086574', 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 278, 'modifier': 'EXACT'}, 'end': {'value': 278, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28283438'}], 'featureId': 'VAR_086575', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 300, 'modifier': 'EXACT'}, 'end': {'value': 300, 'modifier': 'EXACT'}}, 'description': 'in a colorectal cancer sample; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}], 'featureId': 'VAR_036473', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 312, 'modifier': 'EXACT'}, 'end': {'value': 312, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}], 'featureId': 'VAR_086576', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 318, 'modifier': 'EXACT'}, 'end': {'value': 318, 'modifier': 'EXACT'}}, 'description': 'found in a patient with Marfan syndrome-like phenotype; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086577', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 344, 'modifier': 'EXACT'}, 'end': {'value': 358, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8673135'}], 'featureId': 'VAR_011376', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 361, 'modifier': 'EXACT'}, 'end': {'value': 361, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086578', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 388, 'modifier': 'EXACT'}, 'end': {'value': 388, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}], 'featureId': 'VAR_086579', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 397, 'modifier': 'EXACT'}, 'end': {'value': 397, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086580', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 440, 'modifier': 'EXACT'}, 'end': {'value': 440, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011377', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 445, 'modifier': 'EXACT'}, 'end': {'value': 445, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011378', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 449, 'modifier': 'EXACT'}, 'end': {'value': 449, 'modifier': 'EXACT'}}, 'description': 'in LDS6; 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uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086583', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['L']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 19, 'modifier': 'EXACT'}, 'end': {'value': 19, 'modifier': 'EXACT'}}, 'description': 'Loss of acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 20, 'modifier': 'EXACT'}, 'end': {'value': 20, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 221, 'modifier': 'EXACT'}, 'end': {'value': 225, 'modifier': 'EXACT'}}, 'description': 'Loss of binding to SMURF2.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11389444'}], 'alternativeSequence': {}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 368, 'modifier': 'EXACT'}, 'end': {'value': 368, 'modifier': 'EXACT'}}, 'description': 'Loss of interaction with PMEPA1.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}], 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 381, 'modifier': 'EXACT'}, 'end': {'value': 381, 'modifier': 'EXACT'}}, 'description': 'Loss of binding to SARA.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10615055'}], 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['S']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 398, 'modifier': 'EXACT'}, 'end': {'value': 398, 'modifier': 'EXACT'}}, 'description': 'Increased binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}], 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 464, 'modifier': 'EXACT'}, 'end': {'value': 464, 'modifier': 'EXACT'}}, 'description': 'Loss of phosphorylation by TGFBR1; when associated with A-465 and A-467.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Binds RANBP3.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}], 'alternativeSequence': {'originalSequence': 'SMS', 'alternativeSequences': ['AMA']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced RANBP2 binding.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}], 'alternativeSequence': {'originalSequence': 'SMS', 'alternativeSequences': ['DMD']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A. Loss of phosphorylation by TGFBR1; when associated with A-464 and A-467.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A. Loss of phosphorylation by TGFBR1; when associated with A-464 and A-465.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Beta strand', 'location': {'start': {'value': 264, 'modifier': 'EXACT'}, 'end': {'value': 267, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1DEV'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 272, 'modifier': 'EXACT'}, 'end': {'value': 281, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 290, 'modifier': 'EXACT'}, 'end': {'value': 292, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 294, 'modifier': 'EXACT'}, 'end': {'value': 302, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 305, 'modifier': 'EXACT'}, 'end': {'value': 307, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1U7V'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 310, 'modifier': 'EXACT'}, 'end': {'value': 312, 'modifier': 'EXACT'}}, 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'properties': [{'key': 'EntryName', 'value': 'SMAD-like_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR001132', 'properties': [{'key': 'EntryName', 'value': 'SMAD_dom_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR008984', 'properties': [{'key': 'EntryName', 'value': 'SMAD_FHA_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR036578', 'properties': [{'key': 'EntryName', 'value': 'SMAD_MH1_sf'}]}, {'database': 'PANTHER', 'id': 'PTHR13703:SF42', 'properties': [{'key': 'EntryName', 'value': 'MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PANTHER', 'id': 'PTHR13703', 'properties': [{'key': 'EntryName', 'value': 'SMAD'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03165', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03166', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00523', 'properties': [{'key': 'EntryName', 'value': 'DWA'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00524', 'properties': [{'key': 'EntryName', 'value': 'DWB'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF56366', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF49879', 'properties': [{'key': 'EntryName', 'value': 'SMAD/FHA domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51075', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51076', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}], 'sequence': {'value': 'MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS', 'length': 467, 'molWeight': 52306, 'crc64': '95406DB5FC0AA4C9', 'md5': '53ADC62345013C9B257D9D822215079A'}, 'extraAttributes': {'countByCommentType': {'FUNCTION': 1, 'SUBUNIT': 1, 'INTERACTION': 27, 'SUBCELLULAR LOCATION': 1, 'ALTERNATIVE PRODUCTS': 2, 'TISSUE SPECIFICITY': 1, 'PTM': 3, 'DISEASE': 2, 'SIMILARITY': 1, 'WEB RESOURCE': 1}, 'countByFeatureType': {'Initiator methionine': 1, 'Chain': 1, 'Domain': 2, 'Region': 1, 'Motif': 1, 'Compositional bias': 2, 'Binding site': 4, 'Modified residue': 13, 'Alternative sequence': 1, 'Natural variant': 17, 'Mutagenesis': 13, 'Beta strand': 15, 'Helix': 8, 'Turn': 1}, 'uniParcId': 'UPI0000032EE7'}}]\\nENTRY BASE {'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'Q15796', 'uniProtkbId': 'SMAD2_HUMAN', 'entryAudit': {'firstPublicDate': '2001-04-27', 'lastAnnotationUpdateDate': '2025-06-18', 'lastSequenceUpdateDate': '1996-11-01', 'entryVersion': 253, 'sequenceVersion': 1}, 'annotationScore': 5.0, 'organism': {'scientificName': 'Homo sapiens', 'commonName': 'Human', 'taxonId': 9606, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Mothers against decapentaplegic homolog 2'}, 'shortNames': [{'value': 'MAD homolog 2'}, {'value': 'Mothers against DPP homolog 2'}]}, 'alternativeNames': [{'fullName': {'value': 'JV18-1'}}, {'fullName': {'value': 'Mad-related protein 2'}, 'shortNames': [{'value': 'hMAD-2'}]}, {'fullName': {'value': 'SMAD family member 2'}, 'shortNames': [{'value': 'SMAD 2'}, {'value': 'Smad2'}, {'value': 'hSMAD2'}]}]}, 'genes': [{'geneName': {'value': 'SMAD2'}, 'synonyms': [{'value': 'MADH2'}, {'value': 'MADR2'}]}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': 'Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209)'}], 'commentType': 'FUNCTION'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10615055'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10835638'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11278756'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11387212'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11389444'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15350224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15647271'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16200078'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751102'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17099224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17292623'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18568018'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19049980'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24324267'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24627487'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25105025'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9670020'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9702198'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}, {'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '20061380'}], 'value': \\\"Monomer; in the absence of TGF-beta (PubMed:9670020). Heterodimer; in the presence of TGF-beta (PubMed:9670020). Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4 (PubMed:15350224, PubMed:24324267, PubMed:9670020). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta (PubMed:16751102). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (PubMed:24324267). Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD (PubMed:10615055). Interacts with TAZ/WWRT1 (PubMed:18568018). Interacts with FOXH1 (PubMed:9702198). Interacts with SNW1 (PubMed:11278756). Interacts with CREB-binding protein (CBP) and EP300 (PubMed:16862174). Interacts with SNON (PubMed:11389444). Interacts with ALK4/ACVR1B (PubMed:10615055, PubMed:9892009). Interacts with SKOR1 (PubMed:17292623). Interacts with SKOR2 (PubMed:16200078). Interacts with PRDM16 (PubMed:19049980). Interacts (via MH2 domain) with LEMD3 (PubMed:15601644, PubMed:15647271). Interacts with RBPMS (PubMed:17099224). Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (PubMed:19289081). Interacts with PDPK1 (via PH domain) (PubMed:17327236). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (PubMed:11387212). Interacts with USP15 (PubMed:21947082). Interacts with PPP5C (PubMed:22781750). Interacts with LDLRAD4 (via the SMAD interaction motif) (PubMed:24627487). Interacts (via MH2 domain) with PMEPA1 (via the SMAD interaction motif) (PubMed:20129061). Interacts with ZFHX3 (PubMed:25105025). Interacts with ZNF451 (PubMed:24324267). Interacts with SMURF2 when phosphorylated on Ser-465/467 (PubMed:11389444). Interacts with PPM1A (PubMed:16751101). Interacts with TGF-beta (PubMed:8980228). Interacts with TGFBR1 (PubMed:9865696). Interacts with TGIF (PubMed:10835638). Interacts with SMAD3 and TRIM33 (PubMed:16751102). Interacts with ZNF580 (PubMed:21599657). Interacts with NEDD4L in response to TGF-beta (By similarity). Interacts with HGS (By similarity). Interacts with AIP1 (By similarity). Interacts with WWP1 (By similarity). Interacts with PML (By similarity). Interacts weakly with ZNF8 (By similarity). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD2 inhibitors (By similarity). Interacts with YAP1 (when phosphorylated at 'Ser-127') (By similarity). Interacts when phosphorylated with IPO7; the interaction facilitates translocation of SMAD2 to the nucleus (By similarity). Interacts with MTMR4; negatively regulates TGF-beta signaling through SMAD2 dephosphorylation and retention in endosomes (Probable)\\\"}], 'commentType': 'SUBUNIT'}, {'commentType': 'INTERACTION', 'interactions': [{'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q12955', 'geneName': 'ANK3', 'intActId': 'EBI-2691178'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P05060', 'geneName': 'CHGB', 'intActId': 'EBI-712619'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O15111', 'geneName': 'CHUK', 'intActId': 'EBI-81249'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P98082', 'geneName': 'DAB2', 'intActId': 'EBI-1171238'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZ29', 'geneName': 'DOCK9', 'intActId': 'EBI-2695893'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O75593', 'geneName': 'FOXH1', 'intActId': 'EBI-1759806'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P05412', 'geneName': 'JUN', 'intActId': 'EBI-852823'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9NYA4', 'geneName': 'MTMR4', 'intActId': 'EBI-1052346'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P07197', 'geneName': 'NEFM', 'intActId': 'EBI-1105035'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q8TAK6', 'geneName': 'OLIG1', 'intActId': 'EBI-3867416'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P35813', 'geneName': 'PPM1A', 'intActId': 'EBI-989143'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H6Z4', 'geneName': 'RANBP3', 'intActId': 'EBI-992681'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P61586', 'geneName': 'RHOA', 'intActId': 'EBI-446668'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P12755', 'geneName': 'SKI', 'intActId': 'EBI-347281'}, 'numberOfExperiments': 11, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P12757', 'geneName': 'SKIL', 'intActId': 'EBI-2902468'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q15796', 'geneName': 'SMAD2', 'intActId': 'EBI-1040141'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P84022', 'geneName': 'SMAD3', 'intActId': 'EBI-347161'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q13485', 'geneName': 'SMAD4', 'intActId': 'EBI-347263'}, 'numberOfExperiments': 24, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9HAU4', 'geneName': 'SMURF2', 'intActId': 'EBI-396727'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q13573', 'geneName': 'SNW1', 'intActId': 'EBI-632715'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P04637', 'geneName': 'TP53', 'intActId': 'EBI-366083'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H3D4', 'geneName': 'TP63', 'intActId': 'EBI-2337775'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9UPN9', 'geneName': 'TRIM33', 'intActId': 'EBI-2214398'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O00308', 'geneName': 'WWP2', 'intActId': 'EBI-743923'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q96KR1', 'geneName': 'ZFR', 'intActId': 'EBI-2513582'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O95405', 'geneName': 'ZFYVE9', 'intActId': 'EBI-296817'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P70056', 'geneName': 'foxh1', 'intActId': 'EBI-9969973'}, 'numberOfExperiments': 4, 'organismDiffer': True}]}, {'commentType': 'SUBCELLULAR LOCATION', 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 (PubMed:21145499, PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)'}]}, 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Cytoplasm', 'id': 'SL-0086'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Nucleus', 'id': 'SL-0191'}}]}, {'commentType': 'ALTERNATIVE PRODUCTS', 'events': ['Alternative splicing'], 'isoforms': [{'name': {'value': 'Long'}, 'isoformIds': ['Q15796-1'], 'isoformSequenceStatus': 'Displayed'}, {'name': {'value': 'Short'}, 'synonyms': [{'value': 'Smad2Deltaexon3'}], 'isoformIds': ['Q15796-2'], 'sequenceIds': ['VSP_006178'], 'isoformSequenceStatus': 'Described'}]}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}], 'value': 'Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta'}], 'commentType': 'TISSUE SPECIFICITY'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11879191'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12193595'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}], 'value': 'Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'value': \\\"In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding (By similarity). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover (By similarity)\\\"}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}], 'value': 'Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. Isoform short: Acetylation increases DNA binding activity in vitro and enhances its association with target promoters in vivo. Acetylation in the nucleus by EP300 is enhanced by TGF-beta'}], 'commentType': 'PTM'}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Congenital heart defects, multiple types, 8, with or without heterotaxy', 'diseaseAccession': 'DI-06292', 'acronym': 'CHTD8', 'description': 'An autosomal dominant disorder characterized by congenital developmental abnormalities involving structures of the heart. Common CHTD8 features include double-outlet right ventricle, unbalanced complete atrioventricular canal, and valvular anomalies. Vascular anomalies include dextroposition of the great arteries, anomalous pulmonary venous return, and superior vena cava to left atrium defect. Patients may also exhibit laterality defects, including dextrocardia, atrial isomerism, dextrogastria, left-sided gallbladder, and intestinal malrotation.', 'diseaseCrossReference': {'database': 'MIM', 'id': '619657'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23665959'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Loeys-Dietz syndrome 6', 'diseaseAccession': 'DI-06280', 'acronym': 'LDS6', 'description': 'A form of Loeys-Dietz syndrome, a syndrome with widespread systemic involvement characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Most LDS6 patients have thoracic aortic aneurysm involving the ascending aorta and/or aortic root, but cerebral and iliac arteries can be affected, and abdominal aortic aneurysm has been observed. Arterial tortuosity involving cerebral vessels, the aorta, and/or iliac arteries has also been reported. LDS6 inheritance is autosomal dominant.', 'diseaseCrossReference': {'database': 'MIM', 'id': '619656'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28283438'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Belongs to the dwarfin/SMAD family'}], 'commentType': 'SIMILARITY'}, {'commentType': 'WEB RESOURCE', 'resourceName': 'Atlas of Genetics and Cytogenetics in Oncology and Haematology', 'resourceUrl': 'https://atlasgeneticsoncology.org/gene/370/SMAD2', 'ftp': False}], 'features': [{'type': 'Initiator methionine', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 1, 'modifier': 'EXACT'}}, 'description': 'Removed', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22223895'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Chain', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Mothers against decapentaplegic homolog 2', 'featureId': 'PRO_0000090852'}, {'type': 'Domain', 'location': {'start': {'value': 10, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'MH1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00438'}]}, {'type': 'Domain', 'location': {'start': {'value': 274, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'MH2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Region', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Motif', 'location': {'start': {'value': 221, 'modifier': 'EXACT'}, 'end': {'value': 225, 'modifier': 'EXACT'}}, 'description': 'PY-motif'}, {'type': 'Compositional bias', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 217, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Compositional bias', 'location': {'start': {'value': 233, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Binding site', 'location': {'start': {'value': 74, 'modifier': 'EXACT'}, 'end': {'value': 74, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 149, 'modifier': 'EXACT'}, 'end': {'value': 149, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 161, 'modifier': 'EXACT'}, 'end': {'value': 161, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 166, 'modifier': 'EXACT'}, 'end': {'value': 166, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Modified residue', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 2, 'modifier': 'EXACT'}}, 'description': 'N-acetylserine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22223895'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by MAPK3', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12193595'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18691976'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 19, 'modifier': 'EXACT'}, 'end': {'value': 19, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 220, 'modifier': 'EXACT'}, 'end': {'value': 220, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 240, 'modifier': 'EXACT'}, 'end': {'value': 240, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CAMK2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11879191'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 255, 'modifier': 'EXACT'}, 'end': {'value': 255, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 458, 'modifier': 'EXACT'}, 'end': {'value': 458, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18669648'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 460, 'modifier': 'EXACT'}, 'end': {'value': 460, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 464, 'modifier': 'EXACT'}, 'end': {'value': 464, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}]}, {'type': 'Alternative sequence', 'location': {'start': {'value': 79, 'modifier': 'EXACT'}, 'end': {'value': 108, 'modifier': 'EXACT'}}, 'description': 'in isoform Short', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'featureId': 'VSP_006178', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 133, 'modifier': 'EXACT'}, 'end': {'value': 133, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011375', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 159, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}], 'featureId': 'VAR_086573', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 274, 'modifier': 'EXACT'}, 'end': {'value': 274, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23665959'}], 'featureId': 'VAR_086574', 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 278, 'modifier': 'EXACT'}, 'end': {'value': 278, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28283438'}], 'featureId': 'VAR_086575', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 300, 'modifier': 'EXACT'}, 'end': {'value': 300, 'modifier': 'EXACT'}}, 'description': 'in a colorectal cancer sample; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}], 'featureId': 'VAR_036473', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 312, 'modifier': 'EXACT'}, 'end': {'value': 312, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}], 'featureId': 'VAR_086576', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 318, 'modifier': 'EXACT'}, 'end': {'value': 318, 'modifier': 'EXACT'}}, 'description': 'found in a patient with Marfan syndrome-like phenotype; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086577', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 344, 'modifier': 'EXACT'}, 'end': {'value': 358, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8673135'}], 'featureId': 'VAR_011376', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 361, 'modifier': 'EXACT'}, 'end': {'value': 361, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086578', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 388, 'modifier': 'EXACT'}, 'end': {'value': 388, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}], 'featureId': 'VAR_086579', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 397, 'modifier': 'EXACT'}, 'end': {'value': 397, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086580', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 440, 'modifier': 'EXACT'}, 'end': {'value': 440, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011377', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 445, 'modifier': 'EXACT'}, 'end': {'value': 445, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011378', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 449, 'modifier': 'EXACT'}, 'end': {'value': 449, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}], 'featureId': 'VAR_086581', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 450, 'modifier': 'EXACT'}, 'end': {'value': 450, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011379', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 457, 'modifier': 'EXACT'}, 'end': {'value': 457, 'modifier': 'EXACT'}}, 'description': 'in LDS6', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}], 'featureId': 'VAR_086582', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'found in a patient suspected to suffer from Marfan syndrome; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086583', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['L']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 19, 'modifier': 'EXACT'}, 'end': {'value': 19, 'modifier': 'EXACT'}}, 'description': 'Loss of acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 20, 'modifier': 'EXACT'}, 'end': {'value': 20, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 221, 'modifier': 'EXACT'}, 'end': {'value': 225, 'modifier': 'EXACT'}}, 'description': 'Loss of binding to SMURF2.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11389444'}], 'alternativeSequence': {}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 368, 'modifier': 'EXACT'}, 'end': {'value': 368, 'modifier': 'EXACT'}}, 'description': 'Loss of interaction with PMEPA1.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}], 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 381, 'modifier': 'EXACT'}, 'end': {'value': 381, 'modifier': 'EXACT'}}, 'description': 'Loss of binding to SARA.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10615055'}], 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['S']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 398, 'modifier': 'EXACT'}, 'end': {'value': 398, 'modifier': 'EXACT'}}, 'description': 'Increased binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}], 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 464, 'modifier': 'EXACT'}, 'end': {'value': 464, 'modifier': 'EXACT'}}, 'description': 'Loss of phosphorylation by TGFBR1; when associated with A-465 and A-467.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Binds RANBP3.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}], 'alternativeSequence': {'originalSequence': 'SMS', 'alternativeSequences': ['AMA']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced RANBP2 binding.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}], 'alternativeSequence': {'originalSequence': 'SMS', 'alternativeSequences': ['DMD']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A. Loss of phosphorylation by TGFBR1; when associated with A-464 and A-467.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A. Loss of phosphorylation by TGFBR1; when associated with A-464 and A-465.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Beta strand', 'location': {'start': {'value': 264, 'modifier': 'EXACT'}, 'end': {'value': 267, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1DEV'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 272, 'modifier': 'EXACT'}, 'end': {'value': 281, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 290, 'modifier': 'EXACT'}, 'end': {'value': 292, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 294, 'modifier': 'EXACT'}, 'end': {'value': 302, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 305, 'modifier': 'EXACT'}, 'end': {'value': 307, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1U7V'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 310, 'modifier': 'EXACT'}, 'end': {'value': 312, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Helix', 'location': {'start': {'value': 313, 'modifier': 'EXACT'}, 'end': {'value': 315, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Helix', 'location': {'start': {'value': 323, 'modifier': 'EXACT'}, 'end': {'value': 329, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 'Turn', 'location': {'start': {'value': 330, 'modifier': 'EXACT'}, 'end': {'value': 334, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1KHX'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 336, 'modifier': 'EXACT'}, 'end': {'value': 341, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}, {'type': 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{'value': 453, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6M64'}]}], 'keywords': [{'id': 'KW-0002', 'category': 'Technical term', 'name': '3D-structure'}, {'id': 'KW-0007', 'category': 'PTM', 'name': 'Acetylation'}, {'id': 'KW-0025', 'category': 'Coding sequence diversity', 'name': 'Alternative splicing'}, {'id': 'KW-0963', 'category': 'Cellular component', 'name': 'Cytoplasm'}, {'id': 'KW-0903', 'category': 'Technical term', 'name': 'Direct protein sequencing'}, {'id': 'KW-0225', 'category': 'Disease', 'name': 'Disease variant'}, {'id': 'KW-0238', 'category': 'Molecular function', 'name': 'DNA-binding'}, {'id': 'KW-1056', 'category': 'Disease', 'name': 'Heterotaxy'}, {'id': 'KW-0479', 'category': 'Ligand', 'name': 'Metal-binding'}, {'id': 'KW-0539', 'category': 'Cellular component', 'name': 'Nucleus'}, {'id': 'KW-0597', 'category': 'PTM', 'name': 'Phosphoprotein'}, {'id': 'KW-1267', 'category': 'Technical term', 'name': 'Proteomics identification'}, {'id': 'KW-1185', 'category': 'Technical term', 'name': 'Reference proteome'}, {'id': 'KW-0804', 'category': 'Biological process', 'name': 'Transcription'}, {'id': 'KW-0805', 'category': 'Biological process', 'name': 'Transcription regulation'}, {'id': 'KW-0832', 'category': 'PTM', 'name': 'Ubl conjugation'}, {'id': 'KW-0862', 'category': 'Ligand', 'name': 'Zinc'}], 'references': [{'referenceNumber': 1, 'citation': {'id': '8673135', 'citationType': 'journal article', 'authors': ['Riggins G.J.', 'Thiagalingam S.', 'Rosenblum E.', 'Weinstein C.L.', 'Kern S.E.', 'Hamilton S.R.', 'Willson J.K.V.', 'Markowitz S.D.', 'Kinzler K.W.', 'Vogelstein B.V.'], 'citationCrossReferences': [{'database': 'PubMed', 'id': '8673135'}, {'database': 'DOI', 'id': '10.1038/ng0796-347'}], 'title': 'Mad-related genes in the human.', 'publicationDate': '1996', 'journal': 'Nat. 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SER-465 AND SER-467', 'MUTAGENESIS OF SER-464; SER-465 AND SER-467']}, {'referenceNumber': 9, 'citation': {'id': '9865696', 'citationType': 'journal article', 'authors': ['Tsukazaki T.', 'Chiang T.A.', 'Davison A.F.', 'Attisano L.', 'Wrana J.L.'], 'citationCrossReferences': [{'database': 'PubMed', 'id': '9865696'}, {'database': 'DOI', 'id': '10.1016/s0092-8674(00)81701-8'}], 'title': 'SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.', 'publicationDate': '1998', 'journal': 'Cell', 'firstPage': '779', 'lastPage': '791', 'volume': '95'}, 'referencePositions': ['INTERACTION WITH ZFYVE9', 'SUBCELLULAR LOCATION']}, {'referenceNumber': 10, 'citation': {'id': '9670020', 'citationType': 'journal article', 'authors': ['Kawabata M.', 'Inoue H.', 'Hanyu A.', 'Imamura T.', 'Miyazono K.'], 'citationCrossReferences': [{'database': 'PubMed', 'id': '9670020'}, {'database': 'DOI', 'id': '10.1093/emboj/17.14.4056'}], 'title': 'Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors.', 'publicationDate': '1998', 'journal': 'EMBO J.', 'firstPage': '4056', 'lastPage': '4065', 'volume': '17'}, 'referencePositions': ['SUBUNIT', 'INTERACTION WITH SMAD4']}, {'referenceNumber': 11, 'citation': {'id': '9873005', 'citationType': 'journal article', 'authors': ['Yagi K.', 'Goto D.', 'Hamamoto T.', 'Takenoshita S.', 'Kato M.', 'Miyazono K.'], 'citationCrossReferences': [{'database': 'PubMed', 'id': '9873005'}, {'database': 'DOI', 'id': '10.1074/jbc.274.2.703'}], 'title': 'Alternatively spliced variant of Smad2 lacking exon 3. 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'value': 'P:positive regulation of DNA-templated transcription'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9389648'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9732876'}]}, {'database': 'GO', 'id': 'GO:0010718', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of epithelial to mesenchymal transition'}, {'key': 'GoEvidenceType', 'value': 'ISS:BHF-UCL'}]}, {'database': 'GO', 'id': 'GO:0010628', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of gene expression'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0045944', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of transcription by RNA polymerase II'}, {'key': 'GoEvidenceType', 'value': 'IDA:NTNU_SB'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9389648'}]}, {'database': 'GO', 'id': 'GO:0009791', 'properties': [{'key': 'GoTerm', 'value': 'P:post-embryonic development'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0031053', 'properties': [{'key': 'GoTerm', 'value': 'P:primary miRNA processing'}, {'key': 'GoEvidenceType', 'value': 'TAS:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000304', 'source': 'PubMed', 'id': '19018011'}]}, {'database': 'GO', 'id': 'GO:0003184', 'properties': [{'key': 'GoTerm', 'value': 'P:pulmonary valve morphogenesis'}, {'key': 'GoEvidenceType', 'value': 'ISS:BHF-UCL'}]}, {'database': 'GO', 'id': 'GO:0006355', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of DNA-templated transcription'}, {'key': 'GoEvidenceType', 'value': 'NAS:ComplexPortal'}], 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '35359452'}]}, {'database': 'GO', 'id': 'GO:0017015', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of transforming growth factor beta receptor signaling pathway'}, {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000315', 'source': 'PubMed', 'id': '14555988'}]}, {'database': 'GO', 'id': 'GO:0070723', 'properties': [{'key': 'GoTerm', 'value': 'P:response to cholesterol'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '17878231'}]}, {'database': 'GO', 'id': 'GO:0009749', 'properties': [{'key': 'GoTerm', 'value': 'P:response to glucose'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0062009', 'properties': [{'key': 'GoTerm', 'value': 'P:secondary palate development'}, {'key': 'GoEvidenceType', 'value': 'ISS:BHF-UCL'}]}, {'database': 'GO', 'id': 'GO:0060395', 'properties': [{'key': 'GoTerm', 'value': 'P:SMAD protein signal transduction'}, {'key': 'GoEvidenceType', 'value': 'IDA:MGI'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '16806156'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9111321'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9732876'}]}, {'database': 'GO', 'id': 'GO:0007179', 'properties': [{'key': 'GoTerm', 'value': 'P:transforming growth factor beta receptor signaling pathway'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '18548003'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '8752209'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9389648'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9732876'}]}, {'database': 'GO', 'id': 'GO:0061450', 'properties': [{'key': 'GoTerm', 'value': 'P:trophoblast cell migration'}, {'key': 'GoEvidenceType', 'value': 'IDA:UniProt'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '34432647'}]}, {'database': 'GO', 'id': 'GO:0001657', 'properties': [{'key': 'GoTerm', 'value': 'P:ureteric bud development'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0007352', 'properties': [{'key': 'GoTerm', 'value': 'P:zygotic specification of dorsal/ventral axis'}, {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000315', 'source': 'PubMed', 'id': '9436979'}]}, {'database': 'CDD', 'id': 'cd10491', 'properties': [{'key': 'EntryName', 'value': 'MH1_SMAD_2_3'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'CDD', 'id': 'cd10985', 'properties': [{'key': 'EntryName', 'value': 'MH2_SMAD_2_3'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'DisProt', 'id': 'DP01319', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'FunFam', 'id': '2.60.200.10:FF:000001', 'properties': [{'key': 'EntryName', 'value': 'Mothers against decapentaplegic homolog'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'FunFam', 'id': '3.90.520.10:FF:000007', 'properties': [{'key': 'EntryName', 'value': 'Mothers against decapentaplegic homolog'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Gene3D', 'id': '2.60.200.10', 'properties': [{'key': 'EntryName', 'value': '-'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Gene3D', 'id': '3.90.520.10', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'IDEAL', 'id': 'IID00127', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'InterPro', 'id': 'IPR013790', 'properties': [{'key': 'EntryName', 'value': 'Dwarfin'}]}, {'database': 'InterPro', 'id': 'IPR003619', 'properties': [{'key': 'EntryName', 'value': 'MAD_homology1_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR013019', 'properties': [{'key': 'EntryName', 'value': 'MAD_homology_MH1'}]}, {'database': 'InterPro', 'id': 'IPR017855', 'properties': [{'key': 'EntryName', 'value': 'SMAD-like_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR001132', 'properties': [{'key': 'EntryName', 'value': 'SMAD_dom_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR008984', 'properties': [{'key': 'EntryName', 'value': 'SMAD_FHA_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR036578', 'properties': [{'key': 'EntryName', 'value': 'SMAD_MH1_sf'}]}, {'database': 'PANTHER', 'id': 'PTHR13703:SF42', 'properties': [{'key': 'EntryName', 'value': 'MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PANTHER', 'id': 'PTHR13703', 'properties': [{'key': 'EntryName', 'value': 'SMAD'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03165', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03166', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00523', 'properties': [{'key': 'EntryName', 'value': 'DWA'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00524', 'properties': [{'key': 'EntryName', 'value': 'DWB'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF56366', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF49879', 'properties': [{'key': 'EntryName', 'value': 'SMAD/FHA domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51075', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51076', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}], 'sequence': {'value': 'MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS', 'length': 467, 'molWeight': 52306, 'crc64': '95406DB5FC0AA4C9', 'md5': '53ADC62345013C9B257D9D822215079A'}, 'extraAttributes': {'countByCommentType': {'FUNCTION': 1, 'SUBUNIT': 1, 'INTERACTION': 27, 'SUBCELLULAR LOCATION': 1, 'ALTERNATIVE PRODUCTS': 2, 'TISSUE SPECIFICITY': 1, 'PTM': 3, 'DISEASE': 2, 'SIMILARITY': 1, 'WEB RESOURCE': 1}, 'countByFeatureType': {'Initiator methionine': 1, 'Chain': 1, 'Domain': 2, 'Region': 1, 'Motif': 1, 'Compositional bias': 2, 'Binding site': 4, 'Modified residue': 13, 'Alternative sequence': 1, 'Natural variant': 17, 'Mutagenesis': 13, 'Beta strand': 15, 'Helix': 8, 'Turn': 1}, 'uniParcId': 'UPI0000032EE7'}}\\nExtracting summaries\\nExtracting disease traits\\nExtracting function traits\\nExtracting GO terms\\nparse_uniprot_isoforms_localization {'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}\\nExtracted summaries: {'locations': {'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, 'uniprotID': 'Q15796', 'diseases': ['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], 'function': 'Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma', 'go_terms': ['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis']}\\nFetching UniProt entry for gene: SMAD3\\nUNIPROT RESULTS [{'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'P84022', 'secondaryAccessions': ['A8K4B6', 'B7Z4Z5', 'B7Z6M9', 'B7Z9Q2', 'F5H383', 'O09064', 'O09144', 'O14510', 'O35273', 'Q92940', 'Q93002', 'Q9GKR4'], 'uniProtkbId': 'SMAD3_HUMAN', 'entryAudit': {'firstPublicDate': '2004-07-05', 'lastAnnotationUpdateDate': '2025-06-18', 'lastSequenceUpdateDate': '2004-07-05', 'entryVersion': 215, 'sequenceVersion': 1}, 'annotationScore': 5.0, 'organism': {'scientificName': 'Homo sapiens', 'commonName': 'Human', 'taxonId': 9606, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Mothers against decapentaplegic homolog 3'}, 'shortNames': [{'value': 'MAD homolog 3'}, {'value': 'Mad3'}, {'value': 'Mothers against DPP homolog 3'}, {'value': 'hMAD-3'}]}, 'alternativeNames': [{'fullName': {'value': 'JV15-2'}}, {'fullName': {'value': 'SMAD family member 3'}, 'shortNames': [{'value': 'SMAD 3'}, {'value': 'Smad3'}, {'value': 'hSMAD3'}]}]}, 'genes': [{'geneName': {'value': 'SMAD3'}, 'synonyms': [{'value': 'MADH3'}]}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9732876'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': 'Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'}], 'commentType': 'FUNCTION'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P84025'}, {'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11274402'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11278756'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11387212'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11427533'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12154125'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12370310'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14525983'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15051726'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15350224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15561701'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15647271'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15897867'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16200078'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751102'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16777850'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17099224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17292623'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18568018'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19049980'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20061380'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20935647'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24324267'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24613385'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24627487'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25105025'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29899023'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9665135'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9670020'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9732876'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9843571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': \\\"Monomer; in the absence of TGF-beta (PubMed:9670020). Homooligomer; in the presence of TGF-beta (PubMed:9670020). Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex (PubMed:11224571, PubMed:15350224, PubMed:15799969, PubMed:9670020). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:9892009). Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta (PubMed:16751102). Found in a complex composed of SMAD3, RAN and XPO4; within the complex interacts directly with XPO4 (PubMed:16449645). Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta (PubMed:10995748, PubMed:9732876). Part of a ternary complex composed of SMAD3, ITCH/AIP4 and NEDD9/HEF1; within the complex NEDD9/HEF1 interacts (via N-terminus) with ITCH/AIP4; the complex mediates ubiquitination and proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). Interacts with NEDD9; the interaction promotes NEDD9 ubiquitination and proteasomal degradation (PubMed:15051726). Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta (PubMed:10995748, PubMed:9732876). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (PubMed:24324267). Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling (PubMed:16751101). Interacts (via MH2 domain) with ZMIZ1 (via SP-RING-type domain); in the TGF-beta signaling pathway increases the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD3 inhibitors (PubMed:9311995). Interacts (dephosphorylated form via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (PubMed:19289081). Interacts (via MH2 domain) with LEMD3; the interaction represses SMAD3 transcriptional activity through preventing the formation of the heteromeric complex with SMAD4 and translocation to the nucleus (PubMed:15601644, PubMed:15647271). Interacts (via the linker region) with EP300 (C-terminal); the interaction promotes SMAD3 acetylation and is enhanced by TGF-beta phosphorylation in the C-terminal of SMAD3 (PubMed:15588252, PubMed:9843571). This interaction can be blocked by competitive binding of adenovirus oncoprotein E1A to the same C-terminal site on EP300, which then results in partially inhibited SMAD3/SMAD4 transcriptional activity (PubMed:15588252, PubMed:9843571). Interacts with TGFBR1 (PubMed:9311995). Interacts with TGFB1I1 (PubMed:15561701). Interacts with PRDM16 (PubMed:19049980). Interacts with SNW1 (PubMed:11278756). Interacts (via MH2 domain) with ZFYVE9 (PubMed:12154125, PubMed:9865696). Interacts with HDAC1 (PubMed:19049980). Interacts with TGIF2 (PubMed:11427533). Interacts with SKOR1 (PubMed:17292623). Interacts with SKOR2 (PubMed:16200078). Interacts with DACH1; the interaction inhibits the TGF-beta signaling (PubMed:14525983). Interacts with RBPMS (PubMed:17099224). Interacts (via MH2 domain) with MECOM (PubMed:15897867, PubMed:9665135). Interacts with WWTR1 (via its coiled-coil domain) (PubMed:18568018). Interacts with SKI; the interaction represses SMAD3 transcriptional activity (PubMed:19049980). Interacts with MEN1 (PubMed:11274402). Interacts with IL1F7 (PubMed:20935647). Interaction with CSNK1G2 (PubMed:18794808). Interacts with PDPK1 (via PH domain) (PubMed:17327236). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (PubMed:11387212). Interacts with USP15 (PubMed:21947082). Interacts with PPP5C; the interaction decreases SMAD3 phosphorylation and protein levels (PubMed:22781750). Interacts with LDLRAD4 (via the SMAD interaction motif) (PubMed:24627487). Interacts with PMEPA1 (PubMed:20129061). Interacts with ZNF451 (PubMed:24324267). Interacts with ZFHX3 (PubMed:25105025). Interacts weakly with ZNF8 (PubMed:12370310). Interacts with STUB1, HSPA1A, HSPA1B, HSP90AA1 and HSP90AB1 (PubMed:24613385). Interacts with YAP1 (when phosphorylated at 'Ser-127') (By similarity). Interacts with MAGI2/ARIP1 (By similarity). Interacts (via MH2 domain) with CITED2 (via C-terminus) (By similarity). Interacts with HGS (By similarity). Interacts with WWP1 (By similarity). Interacts with TTRAP (By similarity). Interacts with FOXL2 (By similarity). Interacts with PML (By similarity). Interacts with NEDD4L; the interaction requires TGF-beta stimulation (By similarity). Interacts with ZC3H3 (By similarity). Interacts with TGIF. Interacts with CREBBP. Interacts with ATF2. Interacts with NEDD9; the interaction is inhibited by oxidation of NEDD9 (PubMed:29899023). Interacts with MTMR4; negatively regulates TGF-beta signaling through SMAD3 dephosphorylation and retention in endosomes (PubMed:20061380)\\\"}], 'commentType': 'SUBUNIT'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18055455'}], 'value': '(Microbial infection) Interacts with SARS-CoV nucleoprotein'}], 'commentType': 'SUBUNIT'}, {'commentType': 'INTERACTION', 'interactions': [{'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q06481-5', 'geneName': 'APLP2', 'intActId': 'EBI-25646567'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P05067', 'geneName': 'APP', 'intActId': 'EBI-77613'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H2G9', 'geneName': 'BLZF1', 'intActId': 'EBI-2548012'}, 'numberOfExperiments': 9, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9UQM7', 'geneName': 'CAMK2A', 'intActId': 'EBI-1383687'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P29466-3', 'geneName': 'CASP1', 'intActId': 'EBI-12248206'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'E9PSE9', 'geneName': 'CCDC198', 'intActId': 'EBI-11748295'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N5R6', 'geneName': 'CCDC33', 'intActId': 'EBI-740841'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H2X0', 'geneName': 'CHRD', 'intActId': 'EBI-947551'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N684', 'geneName': 'CPSF7', 'intActId': 'EBI-746909'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N684-3', 'geneName': 'CPSF7', 'intActId': 'EBI-11523759'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O43186', 'geneName': 'CRX', 'intActId': 'EBI-748171'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q96PZ7', 'geneName': 'CSMD1', 'intActId': 'EBI-766158'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P48730-2', 'geneName': 'CSNK1D', 'intActId': 'EBI-9087876'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P98082', 'geneName': 'DAB2', 'intActId': 'EBI-1171238'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P17844', 'geneName': 'DDX5', 'intActId': 'EBI-351962'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZ29', 'geneName': 'DOCK9', 'intActId': 'EBI-2695893'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q86YD7', 'geneName': 'FAM90A1', 'intActId': 'EBI-6658203'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q01543', 'geneName': 'FLI1', 'intActId': 'EBI-2271018'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O75593', 'geneName': 'FOXH1', 'intActId': 'EBI-1759806'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O43524', 'geneName': 'FOXO3', 'intActId': 'EBI-1644164'}, 'numberOfExperiments': 5, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P10070', 'geneName': 'GLI2', 'intActId': 'EBI-10821567'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q16665', 'geneName': 'HIF1A', 'intActId': 'EBI-447269'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O15397', 'geneName': 'IPO8', 'intActId': 'EBI-358808'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8WXH2', 'geneName': 'JPH3', 'intActId': 'EBI-1055254'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P50222', 'geneName': 'MEOX2', 'intActId': 'EBI-748397'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9NYA4', 'geneName': 'MTMR4', 'intActId': 'EBI-1052346'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q99836', 'geneName': 'MYD88', 'intActId': 'EBI-447677'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P46934-3', 'geneName': 'NEDD4', 'intActId': 'EBI-11980721'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q16822', 'geneName': 'PCK2', 'intActId': 'EBI-2825219'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8IXK0', 'geneName': 'PHC2', 'intActId': 'EBI-713786'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8IXK0-5', 'geneName': 'PHC2', 'intActId': 'EBI-11527347'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P27986-2', 'geneName': 'PIK3R1', 'intActId': 'EBI-9090282'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZL4', 'geneName': 'PPP1R12C', 'intActId': 'EBI-721802'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P17612', 'geneName': 'PRKACA', 'intActId': 'EBI-476586'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P20618', 'geneName': 'PSMB1', 'intActId': 'EBI-372273'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q96EP0', 'geneName': 'RNF31', 'intActId': 'EBI-948111'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P0C264', 'geneName': 'SBK3', 'intActId': 'EBI-17181801'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BYW2', 'geneName': 'SETD2', 'intActId': 'EBI-945869'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P12755', 'geneName': 'SKI', 'intActId': 'EBI-347281'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q15796', 'geneName': 'SMAD2', 'intActId': 'EBI-1040141'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P84022', 'geneName': 'SMAD3', 'intActId': 'EBI-347161'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13485', 'geneName': 'SMAD4', 'intActId': 'EBI-347263'}, 'numberOfExperiments': 37, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9HAU4', 'geneName': 'SMURF2', 'intActId': 'EBI-396727'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13573', 'geneName': 'SNW1', 'intActId': 'EBI-632715'}, 'numberOfExperiments': 5, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13501', 'geneName': 'SQSTM1', 'intActId': 'EBI-307104'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8WW24', 'geneName': 'TEKT4', 'intActId': 'EBI-750487'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q15583', 'geneName': 'TGIF1', 'intActId': 'EBI-714215'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q08117', 'geneName': 'TLE5', 'intActId': 'EBI-717810'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q08117-2', 'geneName': 'TLE5', 'intActId': 'EBI-11741437'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9Y3Q8', 'geneName': 'TSC22D4', 'intActId': 'EBI-739485'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q93009', 'geneName': 'USP7', 'intActId': 'EBI-302474'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H0M0', 'geneName': 'WWP1', 'intActId': 'EBI-742157'}, 'numberOfExperiments': 9, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O00308', 'geneName': 'WWP2', 'intActId': 'EBI-743923'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q5D1E8', 'geneName': 'ZC3H12A', 'intActId': 'EBI-747793'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O95405', 'geneName': 'ZFYVE9', 'intActId': 'EBI-296817'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q6NX45', 'geneName': 'ZNF774', 'intActId': 'EBI-10251462'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q64729', 'geneName': 'Tgfbr1', 'intActId': 'EBI-2899393'}, 'numberOfExperiments': 6, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O92972', 'chainId': 'PRO_0000278742', 'intActId': 'EBI-9213553'}, 'numberOfExperiments': 6, 'organismDiffer': True}]}, {'commentType': 'SUBCELLULAR LOCATION', 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}], 'value': 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)'}]}, 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}], 'value': 'Cytoplasm', 'id': 'SL-0086'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}], 'value': 'Nucleus', 'id': 'SL-0191'}}]}, {'commentType': 'ALTERNATIVE PRODUCTS', 'events': ['Alternative splicing'], 'isoforms': [{'name': {'value': '1'}, 'isoformIds': ['P84022-1'], 'isoformSequenceStatus': 'Displayed'}, {'name': {'value': '2'}, 'isoformIds': ['P84022-2'], 'sequenceIds': ['VSP_042900'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '3'}, 'isoformIds': ['P84022-3'], 'sequenceIds': ['VSP_043793'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '4'}, 'isoformIds': ['P84022-4'], 'sequenceIds': ['VSP_045348'], 'isoformSequenceStatus': 'Described'}]}, {'texts': [{'value': 'The MH1 domain is required for DNA binding. Also binds zinc ions which are necessary for the DNA binding'}], 'commentType': 'DOMAIN'}, {'texts': [{'value': 'The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import'}], 'commentType': 'DOMAIN'}, {'texts': [{'value': 'The linker region is required for the TGFbeta-mediated transcriptional activity and acts synergistically with the MH2 domain'}], 'commentType': 'DOMAIN'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8774881'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9843571'}], 'value': 'Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF and TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Phosphorylated by PDPK1'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'value': 'Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25133494'}], 'value': 'Poly-ADP-ribosylated by PARP1 and PARP2. ADP-ribosylation negatively regulates SMAD3 transcriptional responses during the course of TGF-beta signaling'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24613385'}], 'value': \\\"Ubiquitinated. Monoubiquitinated, leading to prevent DNA-binding (PubMed:21947082). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD3 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD3 and regulating its turnover (By similarity). Undergoes STUB1-mediated ubiquitination and degradation (PubMed:24613385)\\\"}], 'commentType': 'PTM'}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Colorectal cancer', 'diseaseAccession': 'DI-01359', 'acronym': 'CRC', 'description': 'A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.', 'diseaseCrossReference': {'database': 'MIM', 'id': '114500'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}]}, 'note': {'texts': [{'value': 'The disease may be caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Loeys-Dietz syndrome 3', 'diseaseAccession': 'DI-03064', 'acronym': 'LDS3', 'description': 'An aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by the triad of arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Patients with LDS3 also manifest early-onset osteoarthritis. They lack craniosynostosis and intellectual disability.', 'diseaseCrossReference': {'database': 'MIM', 'id': '613795'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}]}, 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'value': 'The disease is caused by variants affecting the gene represented in this entry. SMAD3 mutations have been reported to be also associated with thoracic aortic aneurysms and dissection (TAAD) (PubMed:21778426). This phenotype is distinguised from LDS3 by having aneurysms restricted to thoracic aorta. As individuals carrying these mutations also exhibit aneurysms of other arteries, including abdominal aorta, iliac, and/or intracranial arteries (PubMed:21778426), they have been classified as LDS3 by the OMIM resource'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Belongs to the dwarfin/SMAD family'}], 'commentType': 'SIMILARITY'}], 'features': [{'type': 'Initiator methionine', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 1, 'modifier': 'EXACT'}}, 'description': 'Removed', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Chain', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Mothers against decapentaplegic homolog 3', 'featureId': 'PRO_0000090856'}, {'type': 'Domain', 'location': {'start': {'value': 10, 'modifier': 'EXACT'}, 'end': {'value': 136, 'modifier': 'EXACT'}}, 'description': 'MH1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00438'}]}, {'type': 'Domain', 'location': {'start': {'value': 232, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'MH2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Region', 'location': {'start': {'value': 137, 'modifier': 'EXACT'}, 'end': {'value': 231, 'modifier': 'EXACT'}}, 'description': 'Linker'}, {'type': 'Region', 'location': {'start': {'value': 165, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Region', 'location': {'start': {'value': 271, 'modifier': 'EXACT'}, 'end': {'value': 324, 'modifier': 'EXACT'}}, 'description': 'Sufficient for interaction with XPO4', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}]}, {'type': 'Compositional bias', 'location': {'start': {'value': 165, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Binding site', 'location': {'start': {'value': 64, 'modifier': 'EXACT'}, 'end': {'value': 64, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 109, 'modifier': 'EXACT'}, 'end': {'value': 109, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 121, 'modifier': 'EXACT'}, 'end': {'value': 121, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 126, 'modifier': 'EXACT'}, 'end': {'value': 126, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Site', 'location': {'start': {'value': 40, 'modifier': 'EXACT'}, 'end': {'value': 40, 'modifier': 'EXACT'}}, 'description': 'Required for trimerization'}, {'type': 'Site', 'location': {'start': {'value': 41, 'modifier': 'EXACT'}, 'end': {'value': 41, 'modifier': 'EXACT'}}, 'description': 'Required for interaction with DNA and JUN and for functional cooperation with JUN'}, {'type': 'Modified residue', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 2, 'modifier': 'EXACT'}}, 'description': 'N-acetylserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by CDK2 and CDK4', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by CDK2, CDK4 and MAPK', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 204, 'modifier': 'EXACT'}, 'end': {'value': 204, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by GSK3 and MAPK', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 208, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by MAPK', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 213, 'modifier': 'EXACT'}, 'end': {'value': 213, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CDK2 and CDK4', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 416, 'modifier': 'EXACT'}, 'end': {'value': 416, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18669648'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CK1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 422, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 423, 'modifier': 'EXACT'}, 'end': {'value': 423, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 425, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 33, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '21947082'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 81, 'modifier': 'EXACT'}, 'end': {'value': 81, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '21947082'}]}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 195, 'modifier': 'EXACT'}}, 'description': 'in isoform 4', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_045348', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 105, 'modifier': 'EXACT'}}, 'description': 'in isoform 3', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_043793', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 68, 'modifier': 'EXACT'}}, 'description': 'in isoform 2', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_042900', 'alternativeSequence': {'originalSequence': 'MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIP', 'alternativeSequences': ['MSCLHPRQTWKGAALVHRKAWWMG']}}, {'type': 'Natural variant', 'location': {'start': {'value': 112, 'modifier': 'EXACT'}, 'end': {'value': 112, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906854', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906854'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067051', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 170, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs35874463', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs35874463'}], 'featureId': 'VAR_052021', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 239, 'modifier': 'EXACT'}, 'end': {'value': 239, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906853', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906853'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067047', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 261, 'modifier': 'EXACT'}, 'end': {'value': 261, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906851', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906851'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}], 'featureId': 'VAR_065578', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 279, 'modifier': 'EXACT'}, 'end': {'value': 279, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906852', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906852'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067048', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 287, 'modifier': 'EXACT'}, 'end': {'value': 287, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906850', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906850'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}], 'featureId': 'VAR_065579', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 393, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'in a colorectal cancer sample; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}], 'featureId': 'VAR_036474', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation, increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-179 and A-213.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['V']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 33, 'modifier': 'EXACT'}}, 'description': 'Slightly decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 40, 'modifier': 'EXACT'}, 'end': {'value': 40, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-41; A-43 and A-44.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 41, 'modifier': 'EXACT'}, 'end': {'value': 41, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced interaction with DNA and JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-44 and A-43.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 43, 'modifier': 'EXACT'}, 'end': {'value': 43, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-41 and A-44.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 44, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with JUN; when associated with A-40; A-41 and A-43.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 53, 'modifier': 'EXACT'}, 'end': {'value': 53, 'modifier': 'EXACT'}}, 'description': 'Slightly decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 74, 'modifier': 'EXACT'}, 'end': {'value': 74, 'modifier': 'EXACT'}}, 'description': 'Reduced interaction with JUN. Loss of transcriptional activity and cooperation with JUN.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 81, 'modifier': 'EXACT'}, 'end': {'value': 81, 'modifier': 'EXACT'}}, 'description': 'Decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['V']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 204, 'modifier': 'EXACT'}, 'end': {'value': 204, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. Further increased transcriptional activity; when associated with S-208.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 208, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. Further increased transcriptional activity; when associated with S-208.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 213, 'modifier': 'EXACT'}, 'end': {'value': 213, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation. Increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and V-179.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 333, 'modifier': 'EXACT'}, 'end': {'value': 333, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-341; R-378 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 341, 'modifier': 'EXACT'}, 'end': {'value': 341, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-378 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. No further increase in transcriptional activity with EP300.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['Q']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced acetylation and 85% reduction in transcriptional activity. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 409, 'modifier': 'EXACT'}, 'end': {'value': 409, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-378.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Increased constitutive activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Decreased activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Does not abolish protein nuclear export. Abolishes almost completely acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'SSVS', 'alternativeSequences': ['AAVA']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Forms heterotrimers.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'SSVS', 'alternativeSequences': ['EEVE']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Diminishes cargo protein export.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'SSVS', 'alternativeSequences': ['RRVR']}}, {'type': 'Sequence conflict', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in Ref. 3; BAA22032', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['EVGTWAAQAGL']}}, {'type': 'Sequence conflict', 'location': {'start': {'value': 360, 'modifier': 'EXACT'}, 'end': {'value': 360, 'modifier': 'EXACT'}}, 'description': 'in Ref. 5; BAH13315', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['L']}}, {'type': 'Helix', 'location': {'start': {'value': 11, 'modifier': 'EXACT'}, 'end': {'value': 17, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Helix', 'location': {'start': {'value': 25, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Helix', 'location': {'start': {'value': 48, 'modifier': 'EXACT'}, 'end': {'value': 57, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 60, 'modifier': 'EXACT'}, 'end': {'value': 62, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 66, 'modifier': 'EXACT'}, 'end': {'value': 68, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 71, 'modifier': 'EXACT'}, 'end': {'value': 73, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '6ZMN'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 75, 'modifier': 'EXACT'}, 'end': {'value': 77, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 80, 'modifier': 'EXACT'}, 'end': {'value': 82, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Helix', 'location': {'start': {'value': 84, 'modifier': 'EXACT'}, 'end': {'value': 92, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Helix', 'location': {'start': {'value': 100, 'modifier': 'EXACT'}, 'end': {'value': 102, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 103, 'modifier': 'EXACT'}, 'end': {'value': 105, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Helix', 'location': {'start': {'value': 113, 'modifier': 'EXACT'}, 'end': {'value': 115, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 118, 'modifier': 'EXACT'}, 'end': {'value': 121, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Helix', 'location': {'start': {'value': 124, 'modifier': 'EXACT'}, 'end': {'value': 126, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 127, 'modifier': 'EXACT'}, 'end': {'value': 129, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '5OD6'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 221, 'modifier': 'EXACT'}, 'end': {'value': 225, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MK2'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 231, 'modifier': 'EXACT'}, 'end': {'value': 239, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 242, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 252, 'modifier': 'EXACT'}, 'end': {'value': 258, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 268, 'modifier': 'EXACT'}, 'end': {'value': 270, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Helix', 'location': {'start': {'value': 271, 'modifier': 'EXACT'}, 'end': {'value': 273, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1U7F'}]}, {'type': 'Helix', 'location': {'start': {'value': 281, 'modifier': 'EXACT'}, 'end': {'value': 290, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 294, 'modifier': 'EXACT'}, 'end': {'value': 299, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 302, 'modifier': 'EXACT'}, 'end': {'value': 307, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 309, 'modifier': 'EXACT'}, 'end': {'value': 311, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 313, 'modifier': 'EXACT'}, 'end': {'value': 316, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Helix', 'location': {'start': {'value': 318, 'modifier': 'EXACT'}, 'end': {'value': 321, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Helix', 'location': {'start': {'value': 323, 'modifier': 'EXACT'}, 'end': {'value': 325, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MK2'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 332, 'modifier': 'EXACT'}, 'end': {'value': 334, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 339, 'modifier': 'EXACT'}, 'end': {'value': 343, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Helix', 'location': {'start': {'value': 345, 'modifier': 'EXACT'}, 'end': {'value': 358, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Helix', 'location': {'start': {'value': 360, 'modifier': 'EXACT'}, 'end': {'value': 364, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Helix', 'location': {'start': {'value': 365, 'modifier': 'EXACT'}, 'end': {'value': 370, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 371, 'modifier': 'EXACT'}, 'end': {'value': 377, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MJS'}]}, {'type': 'Beta strand', 'location': {'start': {'value': 384, 'modifier': 'EXACT'}, 'end': {'value': 386, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1MK2'}]}, {'type': 'Helix', 'location': {'start': {'value': 389, 'modifier': 'EXACT'}, 'end': {'value': 391, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 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'value': '-'}]}, {'database': 'InterPro', 'id': 'IPR013790', 'properties': [{'key': 'EntryName', 'value': 'Dwarfin'}]}, {'database': 'InterPro', 'id': 'IPR003619', 'properties': [{'key': 'EntryName', 'value': 'MAD_homology1_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR013019', 'properties': [{'key': 'EntryName', 'value': 'MAD_homology_MH1'}]}, {'database': 'InterPro', 'id': 'IPR017855', 'properties': [{'key': 'EntryName', 'value': 'SMAD-like_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR001132', 'properties': [{'key': 'EntryName', 'value': 'SMAD_dom_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR008984', 'properties': [{'key': 'EntryName', 'value': 'SMAD_FHA_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR036578', 'properties': [{'key': 'EntryName', 'value': 'SMAD_MH1_sf'}]}, {'database': 'PANTHER', 'id': 'PTHR13703:SF53', 'properties': [{'key': 'EntryName', 'value': 'MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PANTHER', 'id': 'PTHR13703', 'properties': [{'key': 'EntryName', 'value': 'SMAD'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03165', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03166', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00523', 'properties': [{'key': 'EntryName', 'value': 'DWA'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00524', 'properties': [{'key': 'EntryName', 'value': 'DWB'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF56366', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF49879', 'properties': [{'key': 'EntryName', 'value': 'SMAD/FHA domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51075', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51076', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}], 'sequence': {'value': 'MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS', 'length': 425, 'molWeight': 48081, 'crc64': '46DF5E8B371321AC', 'md5': 'E53D209C5415702B891BABFE30ECE27A'}, 'extraAttributes': {'countByCommentType': {'FUNCTION': 1, 'SUBUNIT': 2, 'INTERACTION': 58, 'SUBCELLULAR LOCATION': 1, 'ALTERNATIVE PRODUCTS': 4, 'DOMAIN': 3, 'PTM': 4, 'DISEASE': 2, 'SIMILARITY': 1}, 'countByFeatureType': {'Initiator methionine': 1, 'Chain': 1, 'Domain': 2, 'Region': 3, 'Compositional bias': 1, 'Binding site': 4, 'Site': 2, 'Modified residue': 12, 'Cross-link': 2, 'Alternative sequence': 3, 'Natural variant': 7, 'Mutagenesis': 23, 'Sequence conflict': 2, 'Helix': 16, 'Beta strand': 22}, 'uniParcId': 'UPI0000023A91'}}]\\nENTRY BASE {'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'P84022', 'secondaryAccessions': ['A8K4B6', 'B7Z4Z5', 'B7Z6M9', 'B7Z9Q2', 'F5H383', 'O09064', 'O09144', 'O14510', 'O35273', 'Q92940', 'Q93002', 'Q9GKR4'], 'uniProtkbId': 'SMAD3_HUMAN', 'entryAudit': {'firstPublicDate': '2004-07-05', 'lastAnnotationUpdateDate': '2025-06-18', 'lastSequenceUpdateDate': '2004-07-05', 'entryVersion': 215, 'sequenceVersion': 1}, 'annotationScore': 5.0, 'organism': {'scientificName': 'Homo sapiens', 'commonName': 'Human', 'taxonId': 9606, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Mothers against decapentaplegic homolog 3'}, 'shortNames': [{'value': 'MAD homolog 3'}, {'value': 'Mad3'}, {'value': 'Mothers against DPP homolog 3'}, {'value': 'hMAD-3'}]}, 'alternativeNames': [{'fullName': {'value': 'JV15-2'}}, {'fullName': {'value': 'SMAD family member 3'}, 'shortNames': [{'value': 'SMAD 3'}, {'value': 'Smad3'}, {'value': 'hSMAD3'}]}]}, 'genes': [{'geneName': {'value': 'SMAD3'}, 'synonyms': [{'value': 'MADH3'}]}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9732876'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': 'Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'}], 'commentType': 'FUNCTION'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P84025'}, {'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11274402'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11278756'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11387212'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11427533'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12154125'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12370310'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14525983'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15051726'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15350224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15561701'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15647271'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15897867'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16200078'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751102'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16777850'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17099224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17292623'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18568018'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19049980'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20061380'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20935647'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24324267'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24613385'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24627487'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25105025'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29899023'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9665135'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9670020'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9732876'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9843571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': \\\"Monomer; in the absence of TGF-beta (PubMed:9670020). Homooligomer; in the presence of TGF-beta (PubMed:9670020). Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex (PubMed:11224571, PubMed:15350224, PubMed:15799969, PubMed:9670020). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:9892009). Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta (PubMed:16751102). Found in a complex composed of SMAD3, RAN and XPO4; within the complex interacts directly with XPO4 (PubMed:16449645). Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta (PubMed:10995748, PubMed:9732876). Part of a ternary complex composed of SMAD3, ITCH/AIP4 and NEDD9/HEF1; within the complex NEDD9/HEF1 interacts (via N-terminus) with ITCH/AIP4; the complex mediates ubiquitination and proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). Interacts with NEDD9; the interaction promotes NEDD9 ubiquitination and proteasomal degradation (PubMed:15051726). Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta (PubMed:10995748, PubMed:9732876). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (PubMed:24324267). Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling (PubMed:16751101). Interacts (via MH2 domain) with ZMIZ1 (via SP-RING-type domain); in the TGF-beta signaling pathway increases the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD3 inhibitors (PubMed:9311995). Interacts (dephosphorylated form via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (PubMed:19289081). Interacts (via MH2 domain) with LEMD3; the interaction represses SMAD3 transcriptional activity through preventing the formation of the heteromeric complex with SMAD4 and translocation to the nucleus (PubMed:15601644, PubMed:15647271). Interacts (via the linker region) with EP300 (C-terminal); the interaction promotes SMAD3 acetylation and is enhanced by TGF-beta phosphorylation in the C-terminal of SMAD3 (PubMed:15588252, PubMed:9843571). This interaction can be blocked by competitive binding of adenovirus oncoprotein E1A to the same C-terminal site on EP300, which then results in partially inhibited SMAD3/SMAD4 transcriptional activity (PubMed:15588252, PubMed:9843571). Interacts with TGFBR1 (PubMed:9311995). Interacts with TGFB1I1 (PubMed:15561701). Interacts with PRDM16 (PubMed:19049980). Interacts with SNW1 (PubMed:11278756). Interacts (via MH2 domain) with ZFYVE9 (PubMed:12154125, PubMed:9865696). Interacts with HDAC1 (PubMed:19049980). Interacts with TGIF2 (PubMed:11427533). Interacts with SKOR1 (PubMed:17292623). Interacts with SKOR2 (PubMed:16200078). Interacts with DACH1; the interaction inhibits the TGF-beta signaling (PubMed:14525983). Interacts with RBPMS (PubMed:17099224). Interacts (via MH2 domain) with MECOM (PubMed:15897867, PubMed:9665135). Interacts with WWTR1 (via its coiled-coil domain) (PubMed:18568018). Interacts with SKI; the interaction represses SMAD3 transcriptional activity (PubMed:19049980). Interacts with MEN1 (PubMed:11274402). Interacts with IL1F7 (PubMed:20935647). Interaction with CSNK1G2 (PubMed:18794808). Interacts with PDPK1 (via PH domain) (PubMed:17327236). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (PubMed:11387212). Interacts with USP15 (PubMed:21947082). Interacts with PPP5C; the interaction decreases SMAD3 phosphorylation and protein levels (PubMed:22781750). Interacts with LDLRAD4 (via the SMAD interaction motif) (PubMed:24627487). Interacts with PMEPA1 (PubMed:20129061). Interacts with ZNF451 (PubMed:24324267). Interacts with ZFHX3 (PubMed:25105025). Interacts weakly with ZNF8 (PubMed:12370310). Interacts with STUB1, HSPA1A, HSPA1B, HSP90AA1 and HSP90AB1 (PubMed:24613385). Interacts with YAP1 (when phosphorylated at 'Ser-127') (By similarity). Interacts with MAGI2/ARIP1 (By similarity). Interacts (via MH2 domain) with CITED2 (via C-terminus) (By similarity). Interacts with HGS (By similarity). Interacts with WWP1 (By similarity). Interacts with TTRAP (By similarity). Interacts with FOXL2 (By similarity). Interacts with PML (By similarity). Interacts with NEDD4L; the interaction requires TGF-beta stimulation (By similarity). Interacts with ZC3H3 (By similarity). Interacts with TGIF. Interacts with CREBBP. Interacts with ATF2. Interacts with NEDD9; the interaction is inhibited by oxidation of NEDD9 (PubMed:29899023). Interacts with MTMR4; negatively regulates TGF-beta signaling through SMAD3 dephosphorylation and retention in endosomes (PubMed:20061380)\\\"}], 'commentType': 'SUBUNIT'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18055455'}], 'value': '(Microbial infection) Interacts with SARS-CoV nucleoprotein'}], 'commentType': 'SUBUNIT'}, {'commentType': 'INTERACTION', 'interactions': [{'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q06481-5', 'geneName': 'APLP2', 'intActId': 'EBI-25646567'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P05067', 'geneName': 'APP', 'intActId': 'EBI-77613'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H2G9', 'geneName': 'BLZF1', 'intActId': 'EBI-2548012'}, 'numberOfExperiments': 9, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9UQM7', 'geneName': 'CAMK2A', 'intActId': 'EBI-1383687'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P29466-3', 'geneName': 'CASP1', 'intActId': 'EBI-12248206'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'E9PSE9', 'geneName': 'CCDC198', 'intActId': 'EBI-11748295'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N5R6', 'geneName': 'CCDC33', 'intActId': 'EBI-740841'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H2X0', 'geneName': 'CHRD', 'intActId': 'EBI-947551'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N684', 'geneName': 'CPSF7', 'intActId': 'EBI-746909'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N684-3', 'geneName': 'CPSF7', 'intActId': 'EBI-11523759'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O43186', 'geneName': 'CRX', 'intActId': 'EBI-748171'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q96PZ7', 'geneName': 'CSMD1', 'intActId': 'EBI-766158'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P48730-2', 'geneName': 'CSNK1D', 'intActId': 'EBI-9087876'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P98082', 'geneName': 'DAB2', 'intActId': 'EBI-1171238'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P17844', 'geneName': 'DDX5', 'intActId': 'EBI-351962'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZ29', 'geneName': 'DOCK9', 'intActId': 'EBI-2695893'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q86YD7', 'geneName': 'FAM90A1', 'intActId': 'EBI-6658203'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q01543', 'geneName': 'FLI1', 'intActId': 'EBI-2271018'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O75593', 'geneName': 'FOXH1', 'intActId': 'EBI-1759806'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O43524', 'geneName': 'FOXO3', 'intActId': 'EBI-1644164'}, 'numberOfExperiments': 5, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P10070', 'geneName': 'GLI2', 'intActId': 'EBI-10821567'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q16665', 'geneName': 'HIF1A', 'intActId': 'EBI-447269'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O15397', 'geneName': 'IPO8', 'intActId': 'EBI-358808'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8WXH2', 'geneName': 'JPH3', 'intActId': 'EBI-1055254'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P50222', 'geneName': 'MEOX2', 'intActId': 'EBI-748397'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9NYA4', 'geneName': 'MTMR4', 'intActId': 'EBI-1052346'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q99836', 'geneName': 'MYD88', 'intActId': 'EBI-447677'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P46934-3', 'geneName': 'NEDD4', 'intActId': 'EBI-11980721'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q16822', 'geneName': 'PCK2', 'intActId': 'EBI-2825219'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8IXK0', 'geneName': 'PHC2', 'intActId': 'EBI-713786'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8IXK0-5', 'geneName': 'PHC2', 'intActId': 'EBI-11527347'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P27986-2', 'geneName': 'PIK3R1', 'intActId': 'EBI-9090282'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZL4', 'geneName': 'PPP1R12C', 'intActId': 'EBI-721802'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P17612', 'geneName': 'PRKACA', 'intActId': 'EBI-476586'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P20618', 'geneName': 'PSMB1', 'intActId': 'EBI-372273'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q96EP0', 'geneName': 'RNF31', 'intActId': 'EBI-948111'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P0C264', 'geneName': 'SBK3', 'intActId': 'EBI-17181801'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BYW2', 'geneName': 'SETD2', 'intActId': 'EBI-945869'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P12755', 'geneName': 'SKI', 'intActId': 'EBI-347281'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q15796', 'geneName': 'SMAD2', 'intActId': 'EBI-1040141'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P84022', 'geneName': 'SMAD3', 'intActId': 'EBI-347161'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13485', 'geneName': 'SMAD4', 'intActId': 'EBI-347263'}, 'numberOfExperiments': 37, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9HAU4', 'geneName': 'SMURF2', 'intActId': 'EBI-396727'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13573', 'geneName': 'SNW1', 'intActId': 'EBI-632715'}, 'numberOfExperiments': 5, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13501', 'geneName': 'SQSTM1', 'intActId': 'EBI-307104'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8WW24', 'geneName': 'TEKT4', 'intActId': 'EBI-750487'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q15583', 'geneName': 'TGIF1', 'intActId': 'EBI-714215'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q08117', 'geneName': 'TLE5', 'intActId': 'EBI-717810'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q08117-2', 'geneName': 'TLE5', 'intActId': 'EBI-11741437'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9Y3Q8', 'geneName': 'TSC22D4', 'intActId': 'EBI-739485'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q93009', 'geneName': 'USP7', 'intActId': 'EBI-302474'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H0M0', 'geneName': 'WWP1', 'intActId': 'EBI-742157'}, 'numberOfExperiments': 9, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O00308', 'geneName': 'WWP2', 'intActId': 'EBI-743923'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q5D1E8', 'geneName': 'ZC3H12A', 'intActId': 'EBI-747793'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O95405', 'geneName': 'ZFYVE9', 'intActId': 'EBI-296817'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q6NX45', 'geneName': 'ZNF774', 'intActId': 'EBI-10251462'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q64729', 'geneName': 'Tgfbr1', 'intActId': 'EBI-2899393'}, 'numberOfExperiments': 6, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O92972', 'chainId': 'PRO_0000278742', 'intActId': 'EBI-9213553'}, 'numberOfExperiments': 6, 'organismDiffer': True}]}, {'commentType': 'SUBCELLULAR LOCATION', 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}], 'value': 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)'}]}, 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}], 'value': 'Cytoplasm', 'id': 'SL-0086'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}], 'value': 'Nucleus', 'id': 'SL-0191'}}]}, {'commentType': 'ALTERNATIVE PRODUCTS', 'events': ['Alternative splicing'], 'isoforms': [{'name': {'value': '1'}, 'isoformIds': ['P84022-1'], 'isoformSequenceStatus': 'Displayed'}, {'name': {'value': '2'}, 'isoformIds': ['P84022-2'], 'sequenceIds': ['VSP_042900'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '3'}, 'isoformIds': ['P84022-3'], 'sequenceIds': ['VSP_043793'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '4'}, 'isoformIds': ['P84022-4'], 'sequenceIds': ['VSP_045348'], 'isoformSequenceStatus': 'Described'}]}, {'texts': [{'value': 'The MH1 domain is required for DNA binding. Also binds zinc ions which are necessary for the DNA binding'}], 'commentType': 'DOMAIN'}, {'texts': [{'value': 'The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import'}], 'commentType': 'DOMAIN'}, {'texts': [{'value': 'The linker region is required for the TGFbeta-mediated transcriptional activity and acts synergistically with the MH2 domain'}], 'commentType': 'DOMAIN'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8774881'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9843571'}], 'value': 'Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF and TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Phosphorylated by PDPK1'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'value': 'Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25133494'}], 'value': 'Poly-ADP-ribosylated by PARP1 and PARP2. ADP-ribosylation negatively regulates SMAD3 transcriptional responses during the course of TGF-beta signaling'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24613385'}], 'value': \\\"Ubiquitinated. Monoubiquitinated, leading to prevent DNA-binding (PubMed:21947082). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD3 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD3 and regulating its turnover (By similarity). Undergoes STUB1-mediated ubiquitination and degradation (PubMed:24613385)\\\"}], 'commentType': 'PTM'}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Colorectal cancer', 'diseaseAccession': 'DI-01359', 'acronym': 'CRC', 'description': 'A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.', 'diseaseCrossReference': {'database': 'MIM', 'id': '114500'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}]}, 'note': {'texts': [{'value': 'The disease may be caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Loeys-Dietz syndrome 3', 'diseaseAccession': 'DI-03064', 'acronym': 'LDS3', 'description': 'An aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by the triad of arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Patients with LDS3 also manifest early-onset osteoarthritis. They lack craniosynostosis and intellectual disability.', 'diseaseCrossReference': {'database': 'MIM', 'id': '613795'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}]}, 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'value': 'The disease is caused by variants affecting the gene represented in this entry. SMAD3 mutations have been reported to be also associated with thoracic aortic aneurysms and dissection (TAAD) (PubMed:21778426). This phenotype is distinguised from LDS3 by having aneurysms restricted to thoracic aorta. As individuals carrying these mutations also exhibit aneurysms of other arteries, including abdominal aorta, iliac, and/or intracranial arteries (PubMed:21778426), they have been classified as LDS3 by the OMIM resource'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Belongs to the dwarfin/SMAD family'}], 'commentType': 'SIMILARITY'}], 'features': [{'type': 'Initiator methionine', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 1, 'modifier': 'EXACT'}}, 'description': 'Removed', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Chain', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Mothers against decapentaplegic homolog 3', 'featureId': 'PRO_0000090856'}, {'type': 'Domain', 'location': {'start': {'value': 10, 'modifier': 'EXACT'}, 'end': {'value': 136, 'modifier': 'EXACT'}}, 'description': 'MH1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00438'}]}, {'type': 'Domain', 'location': {'start': {'value': 232, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'MH2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Region', 'location': {'start': {'value': 137, 'modifier': 'EXACT'}, 'end': {'value': 231, 'modifier': 'EXACT'}}, 'description': 'Linker'}, {'type': 'Region', 'location': {'start': {'value': 165, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Region', 'location': {'start': {'value': 271, 'modifier': 'EXACT'}, 'end': {'value': 324, 'modifier': 'EXACT'}}, 'description': 'Sufficient for interaction with XPO4', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}]}, {'type': 'Compositional bias', 'location': {'start': {'value': 165, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Binding site', 'location': {'start': {'value': 64, 'modifier': 'EXACT'}, 'end': {'value': 64, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 109, 'modifier': 'EXACT'}, 'end': {'value': 109, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 121, 'modifier': 'EXACT'}, 'end': {'value': 121, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 126, 'modifier': 'EXACT'}, 'end': {'value': 126, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Site', 'location': {'start': {'value': 40, 'modifier': 'EXACT'}, 'end': {'value': 40, 'modifier': 'EXACT'}}, 'description': 'Required for trimerization'}, {'type': 'Site', 'location': {'start': {'value': 41, 'modifier': 'EXACT'}, 'end': {'value': 41, 'modifier': 'EXACT'}}, 'description': 'Required for interaction with DNA and JUN and for functional cooperation with JUN'}, {'type': 'Modified residue', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 2, 'modifier': 'EXACT'}}, 'description': 'N-acetylserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by CDK2 and CDK4', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by CDK2, CDK4 and MAPK', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 204, 'modifier': 'EXACT'}, 'end': {'value': 204, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by GSK3 and MAPK', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 208, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by MAPK', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 213, 'modifier': 'EXACT'}, 'end': {'value': 213, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CDK2 and CDK4', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 416, 'modifier': 'EXACT'}, 'end': {'value': 416, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18669648'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CK1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 422, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 423, 'modifier': 'EXACT'}, 'end': {'value': 423, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 425, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 33, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '21947082'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 81, 'modifier': 'EXACT'}, 'end': {'value': 81, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '21947082'}]}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 195, 'modifier': 'EXACT'}}, 'description': 'in isoform 4', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_045348', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 105, 'modifier': 'EXACT'}}, 'description': 'in isoform 3', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_043793', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 68, 'modifier': 'EXACT'}}, 'description': 'in isoform 2', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_042900', 'alternativeSequence': {'originalSequence': 'MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIP', 'alternativeSequences': ['MSCLHPRQTWKGAALVHRKAWWMG']}}, {'type': 'Natural variant', 'location': {'start': {'value': 112, 'modifier': 'EXACT'}, 'end': {'value': 112, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906854', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906854'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067051', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 170, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs35874463', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs35874463'}], 'featureId': 'VAR_052021', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 239, 'modifier': 'EXACT'}, 'end': {'value': 239, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906853', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906853'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067047', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 261, 'modifier': 'EXACT'}, 'end': {'value': 261, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906851', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906851'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}], 'featureId': 'VAR_065578', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 279, 'modifier': 'EXACT'}, 'end': {'value': 279, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906852', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906852'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067048', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 287, 'modifier': 'EXACT'}, 'end': {'value': 287, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906850', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906850'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}], 'featureId': 'VAR_065579', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 393, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'in a colorectal cancer sample; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}], 'featureId': 'VAR_036474', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation, increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-179 and A-213.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['V']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 33, 'modifier': 'EXACT'}}, 'description': 'Slightly decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 40, 'modifier': 'EXACT'}, 'end': {'value': 40, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-41; A-43 and A-44.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 41, 'modifier': 'EXACT'}, 'end': {'value': 41, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced interaction with DNA and JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-44 and A-43.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 43, 'modifier': 'EXACT'}, 'end': {'value': 43, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-41 and A-44.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 44, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with JUN; when associated with A-40; A-41 and A-43.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 53, 'modifier': 'EXACT'}, 'end': {'value': 53, 'modifier': 'EXACT'}}, 'description': 'Slightly decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 74, 'modifier': 'EXACT'}, 'end': {'value': 74, 'modifier': 'EXACT'}}, 'description': 'Reduced interaction with JUN. Loss of transcriptional activity and cooperation with JUN.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 81, 'modifier': 'EXACT'}, 'end': {'value': 81, 'modifier': 'EXACT'}}, 'description': 'Decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['V']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 204, 'modifier': 'EXACT'}, 'end': {'value': 204, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. Further increased transcriptional activity; when associated with S-208.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 208, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. Further increased transcriptional activity; when associated with S-208.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 213, 'modifier': 'EXACT'}, 'end': {'value': 213, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation. Increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and V-179.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 333, 'modifier': 'EXACT'}, 'end': {'value': 333, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-341; R-378 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 341, 'modifier': 'EXACT'}, 'end': {'value': 341, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-378 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. No further increase in transcriptional activity with EP300.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['Q']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced acetylation and 85% reduction in transcriptional activity. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 409, 'modifier': 'EXACT'}, 'end': {'value': 409, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-378.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Increased constitutive activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Decreased activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Does not abolish protein nuclear export. Abolishes almost completely acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'SSVS', 'alternativeSequences': ['AAVA']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Forms heterotrimers.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'SSVS', 'alternativeSequences': ['EEVE']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Diminishes cargo protein export.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'SSVS', 'alternativeSequences': ['RRVR']}}, {'type': 'Sequence conflict', 'location': {'start': {'value': 178, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'in Ref. 3; BAA22032', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['EVGTWAAQAGL']}}, {'type': 'Sequence conflict', 'location': {'start': {'value': 360, 'modifier': 'EXACT'}, 'end': {'value': 360, 'modifier': 'EXACT'}}, 'description': 'in Ref. 5; BAH13315', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'alternativeSequence': {'originalSequence': 'F', 'alternativeSequences': ['L']}}, {'type': 'Helix', 'location': {'start': 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{'database': 'GO', 'id': 'GO:0030279', 'properties': [{'key': 'GoTerm', 'value': 'P:negative regulation of ossification'}, {'key': 'GoEvidenceType', 'value': 'IDA:UniProt'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '22155034'}]}, {'database': 'GO', 'id': 'GO:0045668', 'properties': [{'key': 'GoTerm', 'value': 'P:negative regulation of osteoblast differentiation'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0033689', 'properties': [{'key': 'GoTerm', 'value': 'P:negative regulation of osteoblast proliferation'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0042177', 'properties': [{'key': 'GoTerm', 'value': 'P:negative regulation of protein catabolic process'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0000122', 'properties': [{'key': 'GoTerm', 'value': 'P:negative regulation of transcription by RNA polymerase II'}, {'key': 'GoEvidenceType', 'value': 'IDA:ARUK-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '28467929'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '8774881'}]}, {'database': 'GO', 'id': 'GO:0061045', 'properties': [{'key': 'GoTerm', 'value': 'P:negative regulation of wound healing'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0038092', 'properties': [{'key': 'GoTerm', 'value': 'P:nodal signaling pathway'}, {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000315', 'source': 'PubMed', 'id': '15150278'}]}, {'database': 'GO', 'id': 'GO:0002076', 'properties': [{'key': 'GoTerm', 'value': 'P:osteoblast development'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0048340', 'properties': [{'key': 'GoTerm', 'value': 'P:paraxial mesoderm morphogenesis'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0060039', 'properties': [{'key': 'GoTerm', 'value': 'P:pericardium development'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0030501', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of bone mineralization'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0090263', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of canonical Wnt signaling pathway'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0030335', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of cell migration'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0032332', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of chondrocyte differentiation'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0045893', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of DNA-templated transcription'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9111321'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9732876'}]}, {'database': 'GO', 'id': 'GO:0010718', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of epithelial to mesenchymal transition'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '21307346'}]}, {'database': 'GO', 'id': 'GO:1901203', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of extracellular matrix assembly'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '21307346'}]}, {'database': 'GO', 'id': 'GO:0051894', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of focal adhesion assembly'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0010628', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of gene expression'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '21307346'}]}, {'database': 'GO', 'id': 'GO:0032731', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of interleukin-1 beta production'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:1902895', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of miRNA transcription'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '24378993'}]}, {'database': 'GO', 'id': 'GO:0045429', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of nitric oxide biosynthetic process'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '27038547'}]}, {'database': 'GO', 'id': 'GO:0050927', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of positive chemotaxis'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0042307', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of protein import into nucleus'}, {'key': 'GoEvidenceType', 'value': 'NAS:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '15799969'}]}, {'database': 'GO', 'id': 'GO:0060391', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of SMAD protein signal transduction'}, {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000315', 'source': 'PubMed', 'id': '15107418'}]}, {'database': 'GO', 'id': 'GO:0051496', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of stress fiber assembly'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0045944', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of transcription by RNA polymerase II'}, {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '18832382'}]}, {'database': 'GO', 'id': 'GO:0032916', 'properties': [{'key': 'GoTerm', 'value': 'P:positive regulation of transforming growth factor beta3 production'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0031053', 'properties': [{'key': 'GoTerm', 'value': 'P:primary miRNA processing'}, {'key': 'GoEvidenceType', 'value': 'TAS:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000304', 'source': 'PubMed', 'id': '19018011'}]}, {'database': 'GO', 'id': 'GO:0050821', 'properties': [{'key': 'GoTerm', 'value': 'P:protein stabilization'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0006355', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of DNA-templated transcription'}, {'key': 'GoEvidenceType', 'value': 'IDA:ComplexPortal'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '25060702'}]}, {'database': 'GO', 'id': 'GO:0050678', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of epithelial cell proliferation'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0050776', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of immune response'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:1902893', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of miRNA transcription'}, {'key': 'GoEvidenceType', 'value': 'IC:ARUK-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '25605017'}]}, {'database': 'GO', 'id': 'GO:0051881', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of mitochondrial membrane potential'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0016202', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of striated muscle tissue development'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0006357', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of transcription by RNA polymerase II'}, {'key': 'GoEvidenceType', 'value': 'IDA:NTNU_SB'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '21947082'}]}, {'database': 'GO', 'id': 'GO:0017015', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of transforming growth factor beta receptor signaling pathway'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0032909', 'properties': [{'key': 'GoTerm', 'value': 'P:regulation of transforming growth factor beta2 production'}, {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000315', 'source': 'PubMed', 'id': '12411310'}]}, {'database': 'GO', 'id': 'GO:0001836', 'properties': [{'key': 'GoTerm', 'value': 'P:release of cytochrome c from mitochondria'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:1990776', 'properties': [{'key': 'GoTerm', 'value': 'P:response to angiotensin'}, {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000315', 'source': 'PubMed', 'id': '30729664'}]}, {'database': 'GO', 'id': 'GO:0001666', 'properties': [{'key': 'GoTerm', 'value': 'P:response to hypoxia'}, {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000315', 'source': 'PubMed', 'id': '12411310'}]}, {'database': 'GO', 'id': 'GO:0023019', 'properties': [{'key': 'GoTerm', 'value': 'P:signal transduction involved in regulation of gene expression'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0060395', 'properties': [{'key': 'GoTerm', 'value': 'P:SMAD protein signal transduction'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '10823886'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9111321'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9732876'}]}, {'database': 'GO', 'id': 'GO:0001756', 'properties': [{'key': 'GoTerm', 'value': 'P:somitogenesis'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0042110', 'properties': [{'key': 'GoTerm', 'value': 'P:T cell activation'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0030878', 'properties': [{'key': 'GoTerm', 'value': 'P:thyroid gland development'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0060290', 'properties': [{'key': 'GoTerm', 'value': 'P:transdifferentiation'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0007179', 'properties': [{'key': 'GoTerm', 'value': 'P:transforming growth factor beta receptor signaling pathway'}, {'key': 'GoEvidenceType', 'value': 'IDA:UniProtKB'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '21947082'}]}, {'database': 'GO', 'id': 'GO:0061450', 'properties': [{'key': 'GoTerm', 'value': 'P:trophoblast cell migration'}, {'key': 'GoEvidenceType', 'value': 'IDA:UniProt'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '34432647'}]}, {'database': 'GO', 'id': 'GO:0001657', 'properties': [{'key': 'GoTerm', 'value': 'P:ureteric bud development'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0042060', 'properties': [{'key': 'GoTerm', 'value': 'P:wound healing'}, {'key': 'GoEvidenceType', 'value': 'TAS:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000304', 'source': 'PubMed', 'id': '19018011'}]}, {'database': 'CDD', 'id': 'cd10491', 'properties': [{'key': 'EntryName', 'value': 'MH1_SMAD_2_3'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'CDD', 'id': 'cd10985', 'properties': [{'key': 'EntryName', 'value': 'MH2_SMAD_2_3'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'DisProt', 'id': 'DP01648', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'FunFam', 'id': '2.60.200.10:FF:000001', 'properties': [{'key': 'EntryName', 'value': 'Mothers against decapentaplegic homolog'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'FunFam', 'id': '3.90.520.10:FF:000001', 'properties': [{'key': 'EntryName', 'value': 'Mothers against decapentaplegic homolog'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Gene3D', 'id': '2.60.200.10', 'properties': [{'key': 'EntryName', 'value': '-'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Gene3D', 'id': '3.90.520.10', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'IDEAL', 'id': 'IID00113', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'InterPro', 'id': 'IPR013790', 'properties': [{'key': 'EntryName', 'value': 'Dwarfin'}]}, {'database': 'InterPro', 'id': 'IPR003619', 'properties': [{'key': 'EntryName', 'value': 'MAD_homology1_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR013019', 'properties': [{'key': 'EntryName', 'value': 'MAD_homology_MH1'}]}, {'database': 'InterPro', 'id': 'IPR017855', 'properties': [{'key': 'EntryName', 'value': 'SMAD-like_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR001132', 'properties': [{'key': 'EntryName', 'value': 'SMAD_dom_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR008984', 'properties': [{'key': 'EntryName', 'value': 'SMAD_FHA_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR036578', 'properties': [{'key': 'EntryName', 'value': 'SMAD_MH1_sf'}]}, {'database': 'PANTHER', 'id': 'PTHR13703:SF53', 'properties': [{'key': 'EntryName', 'value': 'MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PANTHER', 'id': 'PTHR13703', 'properties': [{'key': 'EntryName', 'value': 'SMAD'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03165', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03166', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00523', 'properties': [{'key': 'EntryName', 'value': 'DWA'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00524', 'properties': [{'key': 'EntryName', 'value': 'DWB'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF56366', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF49879', 'properties': [{'key': 'EntryName', 'value': 'SMAD/FHA domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51075', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51076', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}], 'sequence': {'value': 'MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS', 'length': 425, 'molWeight': 48081, 'crc64': '46DF5E8B371321AC', 'md5': 'E53D209C5415702B891BABFE30ECE27A'}, 'extraAttributes': {'countByCommentType': {'FUNCTION': 1, 'SUBUNIT': 2, 'INTERACTION': 58, 'SUBCELLULAR LOCATION': 1, 'ALTERNATIVE PRODUCTS': 4, 'DOMAIN': 3, 'PTM': 4, 'DISEASE': 2, 'SIMILARITY': 1}, 'countByFeatureType': {'Initiator methionine': 1, 'Chain': 1, 'Domain': 2, 'Region': 3, 'Compositional bias': 1, 'Binding site': 4, 'Site': 2, 'Modified residue': 12, 'Cross-link': 2, 'Alternative sequence': 3, 'Natural variant': 7, 'Mutagenesis': 23, 'Sequence conflict': 2, 'Helix': 16, 'Beta strand': 22}, 'uniParcId': 'UPI0000023A91'}}\\nExtracting summaries\\nExtracting disease traits\\nExtracting function traits\\nExtracting GO terms\\nparse_uniprot_isoforms_localization {'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}\\nExtracted summaries: {'locations': {'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, 'uniprotID': 'P84022', 'diseases': ['Colorectal cancer', 'Loeys-Dietz syndrome 3'], 'function': 'Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator', 'go_terms': ['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing']}\\n*NAME* BioGRID\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': ['SMAD2', 'SMAD3'], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id='Q15796', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma'], diseases=['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={}, nonhuman_interactions={}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, avg_exons_per_transcript=None, transcript_count=None, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id='P84022', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'], diseases=['Colorectal cancer', 'Loeys-Dietz syndrome 3'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={}, nonhuman_interactions={}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, avg_exons_per_transcript=None, transcript_count=None, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry'])}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 0, 'used_tools': ['prot', 'chembl', 'drug_central'], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID'], 'ui': {}, 'prot_html': '\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 2 (Q15796) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 467 UNP Q15796 SMAD2_HUMAN 1 467 \\\\nSEQRES 1 A 467 MET SER SER ILE LEU PRO PHE THR PRO PRO VAL VAL LYS \\\\nSEQRES 2 A 467 ARG LEU LEU GLY TRP LYS LYS SER ALA GLY GLY SER GLY \\\\nSEQRES 3 A 467 GLY ALA GLY GLY GLY GLU GLN ASN GLY GLN GLU GLU LYS \\\\nSEQRES 4 A 467 TRP CYS GLU LYS ALA VAL LYS SER LEU VAL LYS LYS LEU \\\\nSEQRES 5 A 467 LYS LYS THR GLY ARG LEU ASP GLU LEU GLU LYS ALA ILE \\\\nSEQRES 6 A 467 THR THR GLN ASN CYS ASN THR LYS CYS VAL THR ILE PRO \\\\nSEQRES 7 A 467 SER THR CYS SER GLU ILE TRP GLY LEU SER THR PRO ASN \\\\nSEQRES 8 A 467 THR ILE ASP GLN TRP ASP THR THR GLY LEU TYR SER PHE \\\\nSEQRES 9 A 467 SER GLU GLN THR ARG SER LEU ASP GLY ARG LEU GLN VAL \\\\nSEQRES 10 A 467 SER HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG \\\\nSEQRES 11 A 467 LEU TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU \\\\nSEQRES 12 A 467 LYS ALA ILE GLU ASN CYS GLU TYR ALA PHE ASN LEU LYS \\\\nSEQRES 13 A 467 LYS ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG \\\\nSEQRES 14 A 467 VAL GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG \\\\nSEQRES 15 A 467 HIS THR GLU ILE LEU THR GLU LEU PRO PRO LEU ASP ASP \\\\nSEQRES 16 A 467 TYR THR HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA \\\\nSEQRES 17 A 467 GLY ILE GLU PRO GLN SER ASN TYR ILE PRO GLU THR PRO \\\\nSEQRES 18 A 467 PRO PRO GLY TYR ILE SER GLU ASP GLY GLU THR SER ASP \\\\nSEQRES 19 A 467 GLN GLN LEU ASN GLN SER MET ASP THR GLY SER PRO ALA \\\\nSEQRES 20 A 467 GLU LEU SER PRO THR THR LEU SER PRO VAL ASN HIS SER \\\\nSEQRES 21 A 467 LEU ASP LEU GLN PRO VAL THR TYR SER GLU PRO ALA PHE \\\\nSEQRES 22 A 467 TRP CYS SER ILE ALA TYR TYR GLU LEU ASN GLN ARG VAL \\\\nSEQRES 23 A 467 GLY GLU THR PHE HIS ALA SER GLN PRO SER LEU THR VAL \\\\nSEQRES 24 A 467 ASP GLY PHE THR ASP PRO SER ASN SER GLU ARG PHE CYS \\\\nSEQRES 25 A 467 LEU GLY LEU LEU SER ASN VAL ASN ARG ASN ALA THR VAL \\\\nSEQRES 26 A 467 GLU MET THR ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU \\\\nSEQRES 27 A 467 TYR TYR ILE GLY GLY GLU VAL PHE ALA GLU CYS LEU SER \\\\nSEQRES 28 A 467 ASP SER ALA ILE PHE VAL GLN SER PRO ASN CYS ASN GLN \\\\nSEQRES 29 A 467 ARG TYR GLY TRP HIS PRO ALA THR VAL CYS LYS ILE PRO \\\\nSEQRES 30 A 467 PRO GLY CYS ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE \\\\nSEQRES 31 A 467 ALA ALA LEU LEU ALA GLN SER VAL ASN GLN GLY PHE GLU \\\\nSEQRES 32 A 467 ALA VAL TYR GLN LEU THR ARG MET CYS THR ILE ARG MET \\\\nSEQRES 33 A 467 SER PHE VAL LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN \\\\nSEQRES 34 A 467 THR VAL THR SER THR PRO CYS TRP ILE GLU LEU HIS LEU \\\\nSEQRES 35 A 467 ASN GLY PRO LEU GLN TRP LEU ASP LYS VAL LEU THR GLN \\\\nSEQRES 36 A 467 MET GLY SER PRO SER VAL ARG CYS SER SER MET SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 -24.572 -42.101 26.586 1.00 40.65 N \\\\nATOM 2 CA MET A 1 -23.660 -40.986 26.918 1.00 40.65 C \\\\nATOM 3 C MET A 1 -24.312 -39.697 26.444 1.00 40.65 C \\\\nATOM 4 CB MET A 1 -22.280 -41.179 26.264 1.00 40.65 C \\\\nATOM 5 O MET A 1 -24.227 -39.375 25.268 1.00 40.65 O \\\\nATOM 6 CG MET A 1 -21.477 -42.313 26.910 1.00 40.65 C \\\\nATOM 7 SD MET A 1 -19.880 -42.579 26.105 1.00 40.65 S \\\\nATOM 8 CE MET A 1 -19.199 -43.908 27.135 1.00 40.65 C \\\\nATOM 9 N SER A 2 -25.061 -39.026 27.318 1.00 40.07 N \\\\nATOM 10 CA SER A 2 -25.762 -37.787 26.974 1.00 40.07 C \\\\nATOM 11 C SER A 2 -24.744 -36.657 26.853 1.00 40.07 C \\\\nATOM 12 CB SER A 2 -26.833 -37.463 28.023 1.00 40.07 C \\\\nATOM 13 O SER A 2 -24.164 -36.225 27.847 1.00 40.07 O \\\\nATOM 14 OG SER A 2 -27.659 -38.600 28.207 1.00 40.07 O \\\\nATOM 15 N SER A 3 -24.488 -36.213 25.627 1.00 41.96 N \\\\nATOM 16 CA SER A 3 -23.669 -35.042 25.327 1.00 41.96 C \\\\nATOM 17 C SER A 3 -24.297 -33.802 25.968 1.00 41.96 C \\\\nATOM 18 CB SER A 3 -23.571 -34.885 23.804 1.00 41.96 C \\\\nATOM 19 O SER A 3 -25.347 -33.334 25.529 1.00 41.96 O \\\\nATOM 20 OG SER A 3 -24.856 -34.989 23.221 1.00 41.96 O \\\\nATOM 21 N ILE A 4 -23.663 -33.281 27.020 1.00 49.09 N \\\\nATOM 22 CA ILE A 4 -24.019 -32.004 27.645 1.00 49.09 C \\\\nATOM 23 C ILE A 4 -23.817 -30.914 26.587 1.00 49.09 C \\\\nATOM 24 CB ILE A 4 -23.162 -31.774 28.918 1.00 49.09 C \\\\nATOM 25 O ILE A 4 -22.683 -30.590 26.230 1.00 49.09 O \\\\nATOM 26 CG1 ILE A 4 -23.467 -32.865 29.975 1.00 49.09 C \\\\nATOM 27 CG2 ILE A 4 -23.401 -30.371 29.509 1.00 49.09 C \\\\nATOM 28 CD1 ILE A 4 -22.507 -32.870 31.172 1.00 49.09 C \\\\nATOM 29 N LEU A 5 -24.914 -30.374 26.051 1.00 54.35 N \\\\nATOM 30 CA LEU A 5 -24.866 -29.217 25.160 1.00 54.35 C \\\\nATOM 31 C LEU A 5 -24.174 -28.057 25.901 1.00 54.35 C \\\\nATOM 32 CB LEU A 5 -26.287 -28.820 24.715 1.00 54.35 C \\\\nATOM 33 O LEU A 5 -24.526 -27.781 27.052 1.00 54.35 O \\\\nATOM 34 CG LEU A 5 -26.968 -29.818 23.758 1.00 54.35 C \\\\nATOM 35 CD1 LEU A 5 -28.438 -29.436 23.583 1.00 54.35 C \\\\nATOM 36 CD2 LEU A 5 -26.309 -29.824 22.376 1.00 54.35 C \\\\nATOM 37 N PRO A 6 -23.190 -27.372 25.292 1.00 60.96 N \\\\nATOM 38 CA PRO A 6 -22.455 -26.309 25.964 1.00 60.96 C \\\\nATOM 39 C PRO A 6 -23.410 -25.182 26.380 1.00 60.96 C \\\\nATOM 40 CB PRO A 6 -21.373 -25.863 24.972 1.00 60.96 C \\\\nATOM 41 O PRO A 6 -24.093 -24.583 25.551 1.00 60.96 O \\\\nATOM 42 CG PRO A 6 -21.914 -26.299 23.609 1.00 60.96 C \\\\nATOM 43 CD PRO A 6 -22.720 -27.553 23.930 1.00 60.96 C \\\\nATOM 44 N PHE A 7 -23.456 -24.883 27.680 1.00 70.11 N \\\\nATOM 45 CA PHE A 7 -24.301 -23.825 28.228 1.00 70.11 C \\\\nATOM 46 C PHE A 7 -23.821 -22.449 27.741 1.00 70.11 C \\\\nATOM 47 CB PHE A 7 -24.316 -23.929 29.761 1.00 70.11 C \\\\nATOM 48 O PHE A 7 -22.785 -21.940 28.176 1.00 70.11 O \\\\nATOM 49 CG PHE A 7 -25.218 -22.917 30.448 1.00 70.11 C \\\\nATOM 50 CD1 PHE A 7 -24.682 -21.724 30.971 1.00 70.11 C \\\\nATOM 51 CD2 PHE A 7 -26.594 -23.180 30.586 1.00 70.11 C \\\\nATOM 52 CE1 PHE A 7 -25.515 -20.804 31.634 1.00 70.11 C \\\\nATOM 53 CE2 PHE A 7 -27.427 -22.259 31.246 1.00 70.11 C \\\\nATOM 54 CZ PHE A 7 -26.888 -21.073 31.773 1.00 70.11 C \\\\nATOM 55 N THR A 8 -24.572 -21.829 26.831 1.00 74.66 N \\\\nATOM 56 CA THR A 8 -24.329 -20.445 26.401 1.00 74.66 C \\\\nATOM 57 C THR A 8 -25.030 -19.480 27.363 1.00 74.66 C \\\\nATOM 58 CB THR A 8 -24.728 -20.221 24.936 1.00 74.66 C \\\\nATOM 59 O THR A 8 -26.260 -19.534 27.459 1.00 74.66 O \\\\nATOM 60 CG2 THR A 8 -24.478 -18.787 24.475 1.00 74.66 C \\\\nATOM 61 OG1 THR A 8 -23.883 -21.048 24.178 1.00 74.66 O \\\\nATOM 62 N PRO A 9 -24.291 -18.587 28.061 1.00 81.38 N \\\\nATOM 63 CA PRO A 9 -24.875 -17.665 29.034 1.00 81.38 C \\\\nATOM 64 C PRO A 9 -26.022 -16.833 28.430 1.00 81.38 C \\\\nATOM 65 CB PRO A 9 -23.725 -16.765 29.501 1.00 81.38 C \\\\nATOM 66 O PRO A 9 -25.880 -16.379 27.291 1.00 81.38 O \\\\nATOM 67 CG PRO A 9 -22.486 -17.630 29.288 1.00 81.38 C \\\\nATOM 68 CD PRO A 9 -22.839 -18.444 28.047 1.00 81.38 C \\\\nATOM 69 N PRO A 10 -27.113 -16.546 29.170 1.00 88.04 N \\\\nATOM 70 CA PRO A 10 -28.265 -15.803 28.643 1.00 88.04 C \\\\nATOM 71 C PRO A 10 -27.903 -14.455 28.006 1.00 88.04 C \\\\nATOM 72 CB PRO A 10 -29.206 -15.617 29.838 1.00 88.04 C \\\\nATOM 73 O PRO A 10 -28.428 -14.103 26.954 1.00 88.04 O \\\\nATOM 74 CG PRO A 10 -28.904 -16.831 30.714 1.00 88.04 C \\\\nATOM 75 CD PRO A 10 -27.408 -17.050 30.507 1.00 88.04 C \\\\nATOM 76 N VAL A 11 -26.942 -13.728 28.587 1.00 89.17 N \\\\nATOM 77 CA VAL A 11 -26.420 -12.472 28.018 1.00 89.17 C \\\\nATOM 78 C VAL A 11 -25.778 -12.654 26.641 1.00 89.17 C \\\\nATOM 79 CB VAL A 11 -25.444 -11.785 28.991 1.00 89.17 C \\\\nATOM 80 O VAL A 11 -25.989 -11.835 25.755 1.00 89.17 O \\\\nATOM 81 CG1 VAL A 11 -24.266 -12.670 29.436 1.00 89.17 C \\\\nATOM 82 CG2 VAL A 11 -24.874 -10.512 28.374 1.00 89.17 C \\\\nATOM 83 N VAL A 12 -25.047 -13.750 26.421 1.00 90.18 N \\\\nATOM 84 CA VAL A 12 -24.426 -14.037 25.121 1.00 90.18 C \\\\nATOM 85 C VAL A 12 -25.511 -14.301 24.081 1.00 90.18 C \\\\nATOM 86 CB VAL A 12 -23.450 -15.222 25.221 1.00 90.18 C \\\\nATOM 87 O VAL A 12 -25.415 -13.779 22.976 1.00 90.18 O \\\\nATOM 88 CG1 VAL A 12 -22.897 -15.653 23.860 1.00 90.18 C \\\\nATOM 89 CG2 VAL A 12 -22.261 -14.884 26.131 1.00 90.18 C \\\\nATOM 90 N LYS A 13 -26.567 -15.046 24.443 1.00 90.09 N \\\\nATOM 91 CA LYS A 13 -27.716 -15.269 23.551 1.00 90.09 C \\\\nATOM 92 C LYS A 13 -28.409 -13.955 23.179 1.00 90.09 C \\\\nATOM 93 CB LYS A 13 -28.730 -16.246 24.165 1.00 90.09 C \\\\nATOM 94 O LYS A 13 -28.685 -13.747 22.005 1.00 90.09 O \\\\nATOM 95 CG LYS A 13 -28.180 -17.668 24.349 1.00 90.09 C \\\\nATOM 96 CD LYS A 13 -29.318 -18.629 24.722 1.00 90.09 C \\\\nATOM 97 CE LYS A 13 -28.790 -20.054 24.924 1.00 90.09 C \\\\nATOM 98 NZ LYS A 13 -29.892 -21.005 25.223 1.00 90.09 N \\\\nATOM 99 N ARG A 14 -28.629 -13.054 24.148 1.00 91.11 N \\\\nATOM 100 CA ARG A 14 -29.205 -11.720 23.892 1.00 91.11 C \\\\nATOM 101 C ARG A 14 -28.332 -10.898 22.938 1.00 91.11 C \\\\nATOM 102 CB ARG A 14 -29.461 -10.958 25.206 1.00 91.11 C \\\\nATOM 103 O ARG A 14 -28.825 -10.440 21.917 1.00 91.11 O \\\\nATOM 104 CG ARG A 14 -30.632 -11.542 26.016 1.00 91.11 C \\\\nATOM 105 CD ARG A 14 -31.021 -10.655 27.210 1.00 91.11 C \\\\nATOM 106 NE ARG A 14 -29.967 -10.579 28.245 1.00 91.11 N \\\\nATOM 107 NH1 ARG A 14 -30.351 -8.417 28.976 1.00 91.11 N \\\\nATOM 108 NH2 ARG A 14 -28.636 -9.524 29.765 1.00 91.11 N \\\\nATOM 109 CZ ARG A 14 -29.674 -9.525 28.994 1.00 91.11 C \\\\nATOM 110 N LEU A 15 -27.028 -10.803 23.213 1.00 92.52 N \\\\nATOM 111 CA LEU A 15 -26.075 -10.061 22.377 1.00 92.52 C \\\\nATOM 112 C LEU A 15 -25.955 -10.606 20.948 1.00 92.52 C \\\\nATOM 113 CB LEU A 15 -24.703 -10.023 23.065 1.00 92.52 C \\\\nATOM 114 O LEU A 15 -25.822 -9.822 20.009 1.00 92.52 O \\\\nATOM 115 CG LEU A 15 -24.615 -9.069 24.270 1.00 92.52 C \\\\nATOM 116 CD1 LEU A 15 -23.259 -9.267 24.947 1.00 92.52 C \\\\nATOM 117 CD2 LEU A 15 -24.711 -7.596 23.880 1.00 92.52 C \\\\nATOM 118 N LEU A 16 -26.018 -11.929 20.780 1.00 91.58 N \\\\nATOM 119 CA LEU A 16 -26.069 -12.567 19.463 1.00 91.58 C \\\\nATOM 120 C LEU A 16 -27.408 -12.329 18.751 1.00 91.58 C \\\\nATOM 121 CB LEU A 16 -25.795 -14.073 19.608 1.00 91.58 C \\\\nATOM 122 O LEU A 16 -27.421 -12.254 17.529 1.00 91.58 O \\\\nATOM 123 CG LEU A 16 -24.336 -14.414 19.952 1.00 91.58 C \\\\nATOM 124 CD1 LEU A 16 -24.237 -15.887 20.345 1.00 91.58 C \\\\nATOM 125 CD2 LEU A 16 -23.386 -14.167 18.776 1.00 91.58 C \\\\nATOM 126 N GLY A 17 -28.506 -12.153 19.491 1.00 90.58 N \\\\nATOM 127 CA GLY A 17 -29.823 -11.820 18.939 1.00 90.58 C \\\\nATOM 128 C GLY A 17 -29.896 -10.443 18.269 1.00 90.58 C \\\\nATOM 129 O GLY A 17 -30.723 -10.244 17.387 1.00 90.58 O \\\\nATOM 130 N TRP A 18 -29.005 -9.510 18.625 1.00 91.39 N \\\\nATOM 131 CA TRP A 18 -28.865 -8.217 17.938 1.00 91.39 C \\\\nATOM 132 C TRP A 18 -27.843 -8.234 16.792 1.00 91.39 C \\\\nATOM 133 CB TRP A 18 -28.548 -7.112 18.953 1.00 91.39 C \\\\nATOM 134 O TRP A 18 -27.576 -7.184 16.202 1.00 91.39 O \\\\nATOM 135 CG TRP A 18 -29.603 -6.871 19.988 1.00 91.39 C \\\\nATOM 136 CD1 TRP A 18 -30.872 -6.473 19.747 1.00 91.39 C \\\\nATOM 137 CD2 TRP A 18 -29.499 -6.995 21.436 1.00 91.39 C \\\\nATOM 138 CE2 TRP A 18 -30.766 -6.701 22.015 1.00 91.39 C \\\\nATOM 139 CE3 TRP A 18 -28.444 -7.289 22.320 1.00 91.39 C \\\\nATOM 140 NE1 TRP A 18 -31.560 -6.364 20.941 1.00 91.39 N \\\\nATOM 141 CH2 TRP A 18 -29.924 -7.101 24.250 1.00 91.39 C \\\\nATOM 142 CZ2 TRP A 18 -30.987 -6.753 23.399 1.00 91.39 C \\\\nATOM 143 CZ3 TRP A 18 -28.652 -7.369 23.711 1.00 91.39 C \\\\nATOM 144 N LYS A 19 -27.241 -9.392 16.475 1.00 91.72 N \\\\nATOM 145 CA LYS A 19 -26.306 -9.514 15.351 1.00 91.72 C \\\\nATOM 146 C LYS A 19 -27.019 -9.139 14.049 1.00 91.72 C \\\\nATOM 147 CB LYS A 19 -25.718 -10.938 15.266 1.00 91.72 C \\\\nATOM 148 O LYS A 19 -28.107 -9.635 13.766 1.00 91.72 O \\\\nATOM 149 CG LYS A 19 -24.561 -11.002 14.256 1.00 91.72 C \\\\nATOM 150 CD LYS A 19 -23.988 -12.398 13.957 1.00 91.72 C \\\\nATOM 151 CE LYS A 19 -24.732 -13.086 12.796 1.00 91.72 C \\\\nATOM 152 NZ LYS A 19 -23.912 -14.127 12.109 1.00 91.72 N \\\\nATOM 153 N LYS A 20 -26.391 -8.297 13.232 1.00 89.42 N \\\\nATOM 154 CA LYS A 20 -26.866 -8.016 11.872 1.00 89.42 C \\\\nATOM 155 C LYS A 20 -26.457 -9.165 10.944 1.00 89.42 C \\\\nATOM 156 CB LYS A 20 -26.344 -6.646 11.412 1.00 89.42 C \\\\nATOM 157 O LYS A 20 -25.346 -9.681 11.042 1.00 89.42 O \\\\nATOM 158 CG LYS A 20 -26.864 -5.469 12.253 1.00 89.42 C \\\\nATOM 159 CD LYS A 20 -28.377 -5.244 12.136 1.00 89.42 C \\\\nATOM 160 CE LYS A 20 -28.752 -3.968 12.896 1.00 89.42 C \\\\nATOM 161 NZ LYS A 20 -30.202 -3.672 12.787 1.00 89.42 N \\\\nATOM 162 N SER A 21 -27.358 -9.582 10.060 1.00 76.73 N \\\\nATOM 163 CA SER A 21 -27.071 -10.613 9.052 1.00 76.73 C \\\\nATOM 164 C SER A 21 -26.585 -9.953 7.766 1.00 76.73 C \\\\nATOM 165 CB SER A 21 -28.301 -11.487 8.791 1.00 76.73 C \\\\nATOM 166 O SER A 21 -27.132 -8.922 7.375 1.00 76.73 O \\\\nATOM 167 OG SER A 21 -28.651 -12.154 9.990 1.00 76.73 O \\\\nATOM 168 N ALA A 22 -25.577 -10.531 7.110 1.00 64.94 N \\\\nATOM 169 CA ALA A 22 -25.187 -10.124 5.764 1.00 64.94 C \\\\nATOM 170 C ALA A 22 -26.336 -10.489 4.805 1.00 64.94 C \\\\nATOM 171 CB ALA A 22 -23.856 -10.800 5.410 1.00 64.94 C \\\\nATOM 172 O ALA A 22 -26.600 -11.663 4.556 1.00 64.94 O \\\\nATOM 173 N GLY A 23 -27.108 -9.492 4.371 1.00 48.74 N \\\\nATOM 174 CA GLY A 23 -28.290 -9.689 3.538 1.00 48.74 C \\\\nATOM 175 C GLY A 23 -27.919 -10.007 2.093 1.00 48.74 C \\\\nATOM 176 O GLY A 23 -27.514 -9.117 1.356 1.00 48.74 O \\\\nATOM 177 N GLY A 24 -28.113 -11.264 1.698 1.00 39.25 N \\\\nATOM 178 CA GLY A 24 -28.194 -11.733 0.318 1.00 39.25 C \\\\nATOM 179 C GLY A 24 -29.205 -12.877 0.266 1.00 39.25 C \\\\nATOM 180 O GLY A 24 -29.023 -13.914 0.899 1.00 39.25 O \\\\nATOM 181 N SER A 25 -30.318 -12.649 -0.416 1.00 33.12 N \\\\nATOM 182 CA SER A 25 -31.419 -13.586 -0.628 1.00 33.12 C \\\\nATOM 183 C SER A 25 -30.967 -14.913 -1.254 1.00 33.12 C \\\\nATOM 184 CB SER A 25 -32.416 -12.900 -1.572 1.00 33.12 C \\\\nATOM 185 O SER A 25 -30.346 -14.912 -2.309 1.00 33.12 O \\\\nATOM 186 OG SER A 25 -31.719 -12.289 -2.643 1.00 33.12 O \\\\nATOM 187 N GLY A 26 -31.363 -16.033 -0.638 1.00 28.12 N \\\\nATOM 188 CA GLY A 26 -31.713 -17.288 -1.318 1.00 28.12 C \\\\nATOM 189 C GLY A 26 -30.714 -17.865 -2.327 1.00 28.12 C \\\\nATOM 190 O GLY A 26 -31.011 -17.915 -3.514 1.00 28.12 O \\\\nATOM 191 N GLY A 27 -29.588 -18.400 -1.852 1.00 31.96 N \\\\nATOM 192 CA GLY A 27 -28.741 -19.320 -2.619 1.00 31.96 C \\\\nATOM 193 C GLY A 27 -28.473 -20.587 -1.809 1.00 31.96 C \\\\nATOM 194 O GLY A 27 -27.802 -20.534 -0.781 1.00 31.96 O \\\\nATOM 195 N ALA A 28 -29.004 -21.729 -2.247 1.00 35.83 N \\\\nATOM 196 CA ALA A 28 -29.006 -23.014 -1.534 1.00 35.83 C \\\\nATOM 197 C ALA A 28 -27.627 -23.724 -1.429 1.00 35.83 C \\\\nATOM 198 CB ALA A 28 -30.091 -23.891 -2.180 1.00 35.83 C \\\\nATOM 199 O ALA A 28 -27.569 -24.948 -1.371 1.00 35.83 O \\\\nATOM 200 N GLY A 29 -26.513 -22.981 -1.385 1.00 39.37 N \\\\nATOM 201 CA GLY A 29 -25.144 -23.526 -1.411 1.00 39.37 C \\\\nATOM 202 C GLY A 29 -24.241 -23.187 -0.213 1.00 39.37 C \\\\nATOM 203 O GLY A 29 -23.067 -23.534 -0.238 1.00 39.37 O \\\\nATOM 204 N GLY A 30 -24.737 -22.500 0.828 1.00 39.93 N \\\\nATOM 205 CA GLY A 30 -23.887 -21.862 1.859 1.00 39.93 C \\\\nATOM 206 C GLY A 30 -23.858 -22.484 3.267 1.00 39.93 C \\\\nATOM 207 O GLY A 30 -23.334 -21.854 4.188 1.00 39.93 O \\\\nATOM 208 N GLY A 31 -24.432 -23.674 3.480 1.00 42.15 N \\\\nATOM 209 CA GLY A 31 -24.710 -24.205 4.828 1.00 42.15 C \\\\nATOM 210 C GLY A 31 -23.492 -24.328 5.759 1.00 42.15 C \\\\nATOM 211 O GLY A 31 -23.576 -23.985 6.939 1.00 42.15 O \\\\nATOM 212 N GLU A 32 -22.342 -24.764 5.242 1.00 51.18 N \\\\nATOM 213 CA GLU A 32 -21.145 -24.982 6.069 1.00 51.18 C \\\\nATOM 214 C GLU A 32 -20.403 -23.684 6.416 1.00 51.18 C \\\\nATOM 215 CB GLU A 32 -20.194 -25.962 5.376 1.00 51.18 C \\\\nATOM 216 O GLU A 32 -19.970 -23.505 7.559 1.00 51.18 O \\\\nATOM 217 CG GLU A 32 -20.775 -27.382 5.322 1.00 51.18 C \\\\nATOM 218 CD GLU A 32 -19.740 -28.389 4.808 1.00 51.18 C \\\\nATOM 219 OE1 GLU A 32 -19.671 -29.487 5.403 1.00 51.18 O \\\\nATOM 220 OE2 GLU A 32 -19.012 -28.029 3.858 1.00 51.18 O \\\\nATOM 221 N GLN A 33 -20.293 -22.752 5.461 1.00 56.72 N \\\\nATOM 222 CA GLN A 33 -19.598 -21.478 5.677 1.00 56.72 C \\\\nATOM 223 C GLN A 33 -20.337 -20.610 6.701 1.00 56.72 C \\\\nATOM 224 CB GLN A 33 -19.417 -20.721 4.353 1.00 56.72 C \\\\nATOM 225 O GLN A 33 -19.711 -20.066 7.616 1.00 56.72 O \\\\nATOM 226 CG GLN A 33 -18.447 -21.436 3.398 1.00 56.72 C \\\\nATOM 227 CD GLN A 33 -18.143 -20.615 2.147 1.00 56.72 C \\\\nATOM 228 NE2 GLN A 33 -17.830 -21.246 1.038 1.00 56.72 N \\\\nATOM 229 OE1 GLN A 33 -18.163 -19.397 2.144 1.00 56.72 O \\\\nATOM 230 N ASN A 34 -21.671 -20.572 6.618 1.00 67.29 N \\\\nATOM 231 CA ASN A 34 -22.498 -19.839 7.573 1.00 67.29 C \\\\nATOM 232 C ASN A 34 -22.352 -20.414 8.999 1.00 67.29 C \\\\nATOM 233 CB ASN A 34 -23.947 -19.854 7.053 1.00 67.29 C \\\\nATOM 234 O ASN A 34 -22.158 -19.676 9.965 1.00 67.29 O \\\\nATOM 235 CG ASN A 34 -24.826 -18.811 7.724 1.00 67.29 C \\\\nATOM 236 ND2 ASN A 34 -26.122 -18.906 7.550 1.00 67.29 N \\\\nATOM 237 OD1 ASN A 34 -24.377 -17.899 8.394 1.00 67.29 O \\\\nATOM 238 N GLY A 35 -22.302 -21.746 9.141 1.00 76.97 N \\\\nATOM 239 CA GLY A 35 -22.104 -22.400 10.439 1.00 76.97 C \\\\nATOM 240 C GLY A 35 -20.735 -22.124 11.081 1.00 76.97 C \\\\nATOM 241 O GLY A 35 -20.624 -22.025 12.309 1.00 76.97 O \\\\nATOM 242 N GLN A 36 -19.672 -21.979 10.284 1.00 80.76 N \\\\nATOM 243 CA GLN A 36 -18.354 -21.600 10.805 1.00 80.76 C \\\\nATOM 244 C GLN A 36 -18.326 -20.136 11.266 1.00 80.76 C \\\\nATOM 245 CB GLN A 36 -17.275 -21.880 9.750 1.00 80.76 C \\\\nATOM 246 O GLN A 36 -17.717 -19.827 12.298 1.00 80.76 O \\\\nATOM 247 CG GLN A 36 -15.860 -21.709 10.331 1.00 80.76 C \\\\nATOM 248 CD GLN A 36 -14.756 -22.070 9.342 1.00 80.76 C \\\\nATOM 249 NE2 GLN A 36 -13.504 -22.038 9.743 1.00 80.76 N \\\\nATOM 250 OE1 GLN A 36 -14.971 -22.380 8.191 1.00 80.76 O \\\\nATOM 251 N GLU A 37 -18.996 -19.248 10.534 1.00 83.37 N \\\\nATOM 252 CA GLU A 37 -19.110 -17.836 10.887 1.00 83.37 C \\\\nATOM 253 C GLU A 37 -19.920 -17.630 12.171 1.00 83.37 C \\\\nATOM 254 CB GLU A 37 -19.705 -17.064 9.706 1.00 83.37 C \\\\nATOM 255 O GLU A 37 -19.465 -16.931 13.078 1.00 83.37 O \\\\nATOM 256 CG GLU A 37 -19.659 -15.560 9.998 1.00 83.37 C \\\\nATOM 257 CD GLU A 37 -20.107 -14.688 8.825 1.00 83.37 C \\\\nATOM 258 OE1 GLU A 37 -20.015 -13.455 9.018 1.00 83.37 O \\\\nATOM 259 OE2 GLU A 37 -20.523 -15.243 7.790 1.00 83.37 O \\\\nATOM 260 N GLU A 38 -21.059 -18.306 12.322 1.00 85.66 N \\\\nATOM 261 CA GLU A 38 -21.865 -18.251 13.546 1.00 85.66 C \\\\nATOM 262 C GLU A 38 -21.082 -18.708 14.781 1.00 85.66 C \\\\nATOM 263 CB GLU A 38 -23.114 -19.119 13.390 1.00 85.66 C \\\\nATOM 264 O GLU A 38 -21.068 -18.015 15.806 1.00 85.66 O \\\\nATOM 265 CG GLU A 38 -24.157 -18.467 12.474 1.00 85.66 C \\\\nATOM 266 CD GLU A 38 -25.460 -19.276 12.420 1.00 85.66 C \\\\nATOM 267 OE1 GLU A 38 -26.457 -18.690 11.946 1.00 85.66 O \\\\nATOM 268 OE2 GLU A 38 -25.466 -20.426 12.919 1.00 85.66 O \\\\nATOM 269 N LYS A 39 -20.345 -19.823 14.671 1.00 86.55 N \\\\nATOM 270 CA LYS A 39 -19.451 -20.302 15.740 1.00 86.55 C \\\\nATOM 271 C LYS A 39 -18.372 -19.274 16.081 1.00 86.55 C \\\\nATOM 272 CB LYS A 39 -18.795 -21.626 15.317 1.00 86.55 C \\\\nATOM 273 O LYS A 39 -17.981 -19.150 17.245 1.00 86.55 O \\\\nATOM 274 CG LYS A 39 -19.767 -22.812 15.382 1.00 86.55 C \\\\nATOM 275 CD LYS A 39 -19.109 -24.081 14.822 1.00 86.55 C \\\\nATOM 276 CE LYS A 39 -20.135 -25.219 14.776 1.00 86.55 C \\\\nATOM 277 NZ LYS A 39 -19.592 -26.445 14.136 1.00 86.55 N \\\\nATOM 278 N TRP A 40 -17.863 -18.545 15.089 1.00 88.25 N \\\\nATOM 279 CA TRP A 40 -16.889 -17.482 15.316 1.00 88.25 C \\\\nATOM 280 C TRP A 40 -17.515 -16.281 16.041 1.00 88.25 C \\\\nATOM 281 CB TRP A 40 -16.221 -17.086 13.997 1.00 88.25 C \\\\nATOM 282 O TRP A 40 -16.951 -15.825 17.040 1.00 88.25 O \\\\nATOM 283 CG TRP A 40 -15.165 -16.048 14.177 1.00 88.25 C \\\\nATOM 284 CD1 TRP A 40 -13.860 -16.285 14.429 1.00 88.25 C \\\\nATOM 285 CD2 TRP A 40 -15.322 -14.598 14.178 1.00 88.25 C \\\\nATOM 286 CE2 TRP A 40 -14.050 -14.013 14.456 1.00 88.25 C \\\\nATOM 287 CE3 TRP A 40 -16.408 -13.723 13.961 1.00 88.25 C \\\\nATOM 288 NE1 TRP A 40 -13.204 -15.089 14.630 1.00 88.25 N \\\\nATOM 289 CH2 TRP A 40 -14.955 -11.783 14.248 1.00 88.25 C \\\\nATOM 290 CZ2 TRP A 40 -13.857 -12.626 14.495 1.00 88.25 C \\\\nATOM 291 CZ3 TRP A 40 -16.226 -12.329 13.998 1.00 88.25 C \\\\nATOM 292 N CYS A 41 -18.700 -15.828 15.616 1.00 90.26 N \\\\nATOM 293 CA CYS A 41 -19.451 -14.756 16.275 1.00 90.26 C \\\\nATOM 294 C CYS A 41 -19.745 -15.096 17.741 1.00 90.26 C \\\\nATOM 295 CB CYS A 41 -20.771 -14.510 15.529 1.00 90.26 C \\\\nATOM 296 O CYS A 41 -19.511 -14.274 18.629 1.00 90.26 O \\\\nATOM 297 SG CYS A 41 -20.480 -13.830 13.874 1.00 90.26 S \\\\nATOM 298 N GLU A 42 -20.186 -16.325 18.023 1.00 90.51 N \\\\nATOM 299 CA GLU A 42 -20.450 -16.772 19.390 1.00 90.51 C \\\\nATOM 300 C GLU A 42 -19.185 -16.721 20.259 1.00 90.51 C \\\\nATOM 301 CB GLU A 42 -21.072 -18.176 19.365 1.00 90.51 C \\\\nATOM 302 O GLU A 42 -19.226 -16.228 21.390 1.00 90.51 O \\\\nATOM 303 CG GLU A 42 -21.423 -18.629 20.789 1.00 90.51 C \\\\nATOM 304 CD GLU A 42 -22.094 -19.999 20.874 1.00 90.51 C \\\\nATOM 305 OE1 GLU A 42 -22.668 -20.264 21.960 1.00 90.51 O \\\\nATOM 306 OE2 GLU A 42 -21.847 -20.845 20.000 1.00 90.51 O \\\\nATOM 307 N LYS A 43 -18.035 -17.168 19.737 1.00 89.89 N \\\\nATOM 308 CA LYS A 43 -16.750 -17.069 20.449 1.00 89.89 C \\\\nATOM 309 C LYS A 43 -16.331 -15.615 20.685 1.00 89.89 C \\\\nATOM 310 CB LYS A 43 -15.656 -17.823 19.682 1.00 89.89 C \\\\nATOM 311 O LYS A 43 -15.843 -15.308 21.776 1.00 89.89 O \\\\nATOM 312 CG LYS A 43 -15.801 -19.351 19.770 1.00 89.89 C \\\\nATOM 313 CD LYS A 43 -14.681 -20.010 18.954 1.00 89.89 C \\\\nATOM 314 CE LYS A 43 -14.843 -21.529 18.842 1.00 89.89 C \\\\nATOM 315 NZ LYS A 43 -13.695 -22.134 18.114 1.00 89.89 N \\\\nATOM 316 N ALA A 44 -16.529 -14.728 19.707 1.00 90.90 N \\\\nATOM 317 CA ALA A 44 -16.215 -13.304 19.832 1.00 90.90 C \\\\nATOM 318 C ALA A 44 -17.040 -12.649 20.951 1.00 90.90 C \\\\nATOM 319 CB ALA A 44 -16.439 -12.611 18.479 1.00 90.90 C \\\\nATOM 320 O ALA A 44 -16.475 -12.035 21.857 1.00 90.90 O \\\\nATOM 321 N VAL A 45 -18.359 -12.866 20.957 1.00 93.13 N \\\\nATOM 322 CA VAL A 45 -19.264 -12.328 21.985 1.00 93.13 C \\\\nATOM 323 C VAL A 45 -18.977 -12.940 23.359 1.00 93.13 C \\\\nATOM 324 CB VAL A 45 -20.738 -12.517 21.575 1.00 93.13 C \\\\nATOM 325 O VAL A 45 -18.897 -12.206 24.342 1.00 93.13 O \\\\nATOM 326 CG1 VAL A 45 -21.709 -12.028 22.656 1.00 93.13 C \\\\nATOM 327 CG2 VAL A 45 -21.050 -11.716 20.305 1.00 93.13 C \\\\nATOM 328 N LYS A 46 -18.734 -14.257 23.460 1.00 90.75 N \\\\nATOM 329 CA LYS A 46 -18.327 -14.904 24.727 1.00 90.75 C \\\\nATOM 330 C LYS A 46 -17.047 -14.284 25.295 1.00 90.75 C \\\\nATOM 331 CB LYS A 46 -18.140 -16.425 24.535 1.00 90.75 C \\\\nATOM 332 O LYS A 46 -16.974 -14.020 26.497 1.00 90.75 O \\\\nATOM 333 CG LYS A 46 -19.477 -17.178 24.493 1.00 90.75 C \\\\nATOM 334 CD LYS A 46 -19.334 -18.690 24.241 1.00 90.75 C \\\\nATOM 335 CE LYS A 46 -20.738 -19.316 24.203 1.00 90.75 C \\\\nATOM 336 NZ LYS A 46 -20.772 -20.741 23.784 1.00 90.75 N \\\\nATOM 337 N SER A 47 -16.056 -14.031 24.437 1.00 89.31 N \\\\nATOM 338 CA SER A 47 -14.799 -13.380 24.817 1.00 89.31 C \\\\nATOM 339 C SER A 47 -15.031 -11.948 25.303 1.00 89.31 C \\\\nATOM 340 CB SER A 47 -13.825 -13.406 23.636 1.00 89.31 C \\\\nATOM 341 O SER A 47 -14.521 -11.576 26.363 1.00 89.31 O \\\\nATOM 342 OG SER A 47 -12.541 -12.957 24.032 1.00 89.31 O \\\\nATOM 343 N LEU A 48 -15.863 -11.169 24.599 1.00 92.11 N \\\\nATOM 344 CA LEU A 48 -16.211 -9.811 25.014 1.00 92.11 C \\\\nATOM 345 C LEU A 48 -16.908 -9.789 26.372 1.00 92.11 C \\\\nATOM 346 CB LEU A 48 -17.112 -9.131 23.972 1.00 92.11 C \\\\nATOM 347 O LEU A 48 -16.472 -9.073 27.267 1.00 92.11 O \\\\nATOM 348 CG LEU A 48 -17.369 -7.649 24.313 1.00 92.11 C \\\\nATOM 349 CD1 LEU A 48 -16.103 -6.796 24.387 1.00 92.11 C \\\\nATOM 350 CD2 LEU A 48 -18.318 -7.034 23.304 1.00 92.11 C \\\\nATOM 351 N VAL A 49 -17.948 -10.606 26.555 1.00 92.83 N \\\\nATOM 352 CA VAL A 49 -18.707 -10.674 27.811 1.00 92.83 C \\\\nATOM 353 C VAL A 49 -17.786 -11.020 28.981 1.00 92.83 C \\\\nATOM 354 CB VAL A 49 -19.863 -11.686 27.690 1.00 92.83 C \\\\nATOM 355 O VAL A 49 -17.889 -10.408 30.042 1.00 92.83 O \\\\nATOM 356 CG1 VAL A 49 -20.549 -11.969 29.034 1.00 92.83 C \\\\nATOM 357 CG2 VAL A 49 -20.943 -11.156 26.741 1.00 92.83 C \\\\nATOM 358 N LYS A 50 -16.836 -11.949 28.798 1.00 89.33 N \\\\nATOM 359 CA LYS A 50 -15.842 -12.282 29.831 1.00 89.33 C \\\\nATOM 360 C LYS A 50 -14.967 -11.079 30.205 1.00 89.33 C \\\\nATOM 361 CB LYS A 50 -14.997 -13.479 29.361 1.00 89.33 C \\\\nATOM 362 O LYS A 50 -14.634 -10.933 31.378 1.00 89.33 O \\\\nATOM 363 CG LYS A 50 -14.066 -14.014 30.465 1.00 89.33 C \\\\nATOM 364 CD LYS A 50 -13.259 -15.231 29.984 1.00 89.33 C \\\\nATOM 365 CE LYS A 50 -12.365 -15.766 31.114 1.00 89.33 C \\\\nATOM 366 NZ LYS A 50 -11.588 -16.967 30.703 1.00 89.33 N \\\\nATOM 367 N LYS A 51 -14.597 -10.230 29.238 1.00 88.71 N \\\\nATOM 368 CA LYS A 51 -13.817 -9.003 29.480 1.00 88.71 C \\\\nATOM 369 C LYS A 51 -14.659 -7.919 30.158 1.00 88.71 C \\\\nATOM 370 CB LYS A 51 -13.192 -8.490 28.171 1.00 88.71 C \\\\nATOM 371 O LYS A 51 -14.231 -7.385 31.174 1.00 88.71 O \\\\nATOM 372 CG LYS A 51 -12.089 -9.419 27.637 1.00 88.71 C \\\\nATOM 373 CD LYS A 51 -11.479 -8.842 26.352 1.00 88.71 C \\\\nATOM 374 CE LYS A 51 -10.367 -9.752 25.816 1.00 88.71 C \\\\nATOM 375 NZ LYS A 51 -9.566 -9.062 24.772 1.00 88.71 N \\\\nATOM 376 N LEU A 52 -15.874 -7.662 29.674 1.00 92.02 N \\\\nATOM 377 CA LEU A 52 -16.737 -6.597 30.202 1.00 92.02 C \\\\nATOM 378 C LEU A 52 -17.308 -6.897 31.591 1.00 92.02 C \\\\nATOM 379 CB LEU A 52 -17.871 -6.289 29.216 1.00 92.02 C \\\\nATOM 380 O LEU A 52 -17.553 -5.970 32.358 1.00 92.02 O \\\\nATOM 381 CG LEU A 52 -17.411 -5.796 27.835 1.00 92.02 C \\\\nATOM 382 CD1 LEU A 52 -18.646 -5.450 27.015 1.00 92.02 C \\\\nATOM 383 CD2 LEU A 52 -16.510 -4.565 27.878 1.00 92.02 C \\\\nATOM 384 N LYS A 53 -17.466 -8.177 31.956 1.00 90.21 N \\\\nATOM 385 CA LYS A 53 -17.799 -8.568 33.336 1.00 90.21 C \\\\nATOM 386 C LYS A 53 -16.706 -8.190 34.335 1.00 90.21 C \\\\nATOM 387 CB LYS A 53 -18.079 -10.075 33.425 1.00 90.21 C \\\\nATOM 388 O LYS A 53 -17.027 -7.907 35.480 1.00 90.21 O \\\\nATOM 389 CG LYS A 53 -19.488 -10.416 32.930 1.00 90.21 C \\\\nATOM 390 CD LYS A 53 -19.791 -11.901 33.151 1.00 90.21 C \\\\nATOM 391 CE LYS A 53 -21.242 -12.185 32.753 1.00 90.21 C \\\\nATOM 392 NZ LYS A 53 -21.682 -13.518 33.232 1.00 90.21 N \\\\nATOM 393 N LYS A 54 -15.435 -8.178 33.916 1.00 86.28 N \\\\nATOM 394 CA LYS A 54 -14.317 -7.762 34.778 1.00 86.28 C \\\\nATOM 395 C LYS A 54 -14.244 -6.244 34.944 1.00 86.28 C \\\\nATOM 396 CB LYS A 54 -12.983 -8.291 34.238 1.00 86.28 C \\\\nATOM 397 O LYS A 54 -13.834 -5.789 36.000 1.00 86.28 O \\\\nATOM 398 CG LYS A 54 -12.859 -9.818 34.308 1.00 86.28 C \\\\nATOM 399 CD LYS A 54 -11.468 -10.222 33.806 1.00 86.28 C \\\\nATOM 400 CE LYS A 54 -11.221 -11.720 33.988 1.00 86.28 C \\\\nATOM 401 NZ LYS A 54 -9.779 -12.030 33.803 1.00 86.28 N \\\\nATOM 402 N THR A 55 -14.635 -5.479 33.922 1.00 85.96 N \\\\nATOM 403 CA THR A 55 -14.583 -4.005 33.936 1.00 85.96 C \\\\nATOM 404 C THR A 55 -15.893 -3.341 34.372 1.00 85.96 C \\\\nATOM 405 CB THR A 55 -14.146 -3.452 32.568 1.00 85.96 C \\\\nATOM 406 O THR A 55 -15.940 -2.122 34.496 1.00 85.96 O \\\\nATOM 407 CG2 THR A 55 -12.763 -3.949 32.150 1.00 85.96 C \\\\nATOM 408 OG1 THR A 55 -15.038 -3.846 31.547 1.00 85.96 O \\\\nATOM 409 N GLY A 56 -16.972 -4.108 34.575 1.00 88.71 N \\\\nATOM 410 CA GLY A 56 -18.290 -3.575 34.942 1.00 88.71 C \\\\nATOM 411 C GLY A 56 -18.988 -2.791 33.821 1.00 88.71 C \\\\nATOM 412 O GLY A 56 -19.892 -2.010 34.088 1.00 88.71 O \\\\nATOM 413 N ARG A 57 -18.578 -2.970 32.557 1.00 89.65 N \\\\nATOM 414 CA ARG A 57 -19.094 -2.215 31.392 1.00 89.65 C \\\\nATOM 415 C ARG A 57 -20.141 -2.977 30.570 1.00 89.65 C \\\\nATOM 416 CB ARG A 57 -17.914 -1.754 30.516 1.00 89.65 C \\\\nATOM 417 O ARG A 57 -20.518 -2.529 29.490 1.00 89.65 O \\\\nATOM 418 CG ARG A 57 -16.913 -0.808 31.193 1.00 89.65 C \\\\nATOM 419 CD ARG A 57 -17.510 0.564 31.522 1.00 89.65 C \\\\nATOM 420 NE ARG A 57 -16.465 1.467 32.040 1.00 89.65 N \\\\nATOM 421 NH1 ARG A 57 -17.446 3.467 31.478 1.00 89.65 N \\\\nATOM 422 NH2 ARG A 57 -15.450 3.456 32.477 1.00 89.65 N \\\\nATOM 423 CZ ARG A 57 -16.463 2.787 32.001 1.00 89.65 C \\\\nATOM 424 N LEU A 58 -20.583 -4.146 31.039 1.00 92.08 N \\\\nATOM 425 CA LEU A 58 -21.513 -5.006 30.299 1.00 92.08 C \\\\nATOM 426 C LEU A 58 -22.893 -4.354 30.123 1.00 92.08 C \\\\nATOM 427 CB LEU A 58 -21.603 -6.366 31.010 1.00 92.08 C \\\\nATOM 428 O LEU A 58 -23.426 -4.374 29.017 1.00 92.08 O \\\\nATOM 429 CG LEU A 58 -22.493 -7.403 30.296 1.00 92.08 C \\\\nATOM 430 CD1 LEU A 58 -21.978 -7.747 28.893 1.00 92.08 C \\\\nATOM 431 CD2 LEU A 58 -22.483 -8.687 31.132 1.00 92.08 C \\\\nATOM 432 N ASP A 59 -23.422 -3.728 31.174 1.00 92.16 N \\\\nATOM 433 CA ASP A 59 -24.736 -3.072 31.134 1.00 92.16 C \\\\nATOM 434 C ASP A 59 -24.733 -1.855 30.197 1.00 92.16 C \\\\nATOM 435 CB ASP A 59 -25.151 -2.655 32.554 1.00 92.16 C \\\\nATOM 436 O ASP A 59 -25.700 -1.618 29.476 1.00 92.16 O \\\\nATOM 437 CG ASP A 59 -25.249 -3.839 33.523 1.00 92.16 C \\\\nATOM 438 OD1 ASP A 59 -25.561 -4.960 33.061 1.00 92.16 O \\\\nATOM 439 OD2 ASP A 59 -24.929 -3.629 34.711 1.00 92.16 O \\\\nATOM 440 N GLU A 60 -23.615 -1.123 30.132 1.00 92.46 N \\\\nATOM 441 CA GLU A 60 -23.435 -0.012 29.188 1.00 92.46 C \\\\nATOM 442 C GLU A 60 -23.424 -0.503 27.732 1.00 92.46 C \\\\nATOM 443 CB GLU A 60 -22.143 0.763 29.502 1.00 92.46 C \\\\nATOM 444 O GLU A 60 -24.003 0.152 26.867 1.00 92.46 O \\\\nATOM 445 CG GLU A 60 -22.169 1.524 30.841 1.00 92.46 C \\\\nATOM 446 CD GLU A 60 -23.135 2.728 30.898 1.00 92.46 C \\\\nATOM 447 OE1 GLU A 60 -23.315 3.275 32.013 1.00 92.46 O \\\\nATOM 448 OE2 GLU A 60 -23.622 3.188 29.838 1.00 92.46 O \\\\nATOM 449 N LEU A 61 -22.840 -1.678 27.449 1.00 93.87 N \\\\nATOM 450 CA LEU A 61 -22.908 -2.284 26.114 1.00 93.87 C \\\\nATOM 451 C LEU A 61 -24.337 -2.705 25.755 1.00 93.87 C \\\\nATOM 452 CB LEU A 61 -21.944 -3.481 26.011 1.00 93.87 C \\\\nATOM 453 O LEU A 61 -24.794 -2.415 24.650 1.00 93.87 O \\\\nATOM 454 CG LEU A 61 -21.969 -4.148 24.618 1.00 93.87 C \\\\nATOM 455 CD1 LEU A 61 -21.420 -3.231 23.519 1.00 93.87 C \\\\nATOM 456 CD2 LEU A 61 -21.150 -5.433 24.618 1.00 93.87 C \\\\nATOM 457 N GLU A 62 -25.045 -3.378 26.668 1.00 93.54 N \\\\nATOM 458 CA GLU A 62 -26.443 -3.769 26.441 1.00 93.54 C \\\\nATOM 459 C GLU A 62 -27.325 -2.540 26.204 1.00 93.54 C \\\\nATOM 460 CB GLU A 62 -26.995 -4.589 27.621 1.00 93.54 C \\\\nATOM 461 O GLU A 62 -28.126 -2.525 25.266 1.00 93.54 O \\\\nATOM 462 CG GLU A 62 -26.402 -6.004 27.667 1.00 93.54 C \\\\nATOM 463 CD GLU A 62 -27.088 -6.953 28.667 1.00 93.54 C \\\\nATOM 464 OE1 GLU A 62 -26.574 -8.083 28.830 1.00 93.54 O \\\\nATOM 465 OE2 GLU A 62 -28.202 -6.695 29.181 1.00 93.54 O \\\\nATOM 466 N LYS A 63 -27.129 -1.479 26.994 1.00 93.28 N \\\\nATOM 467 CA LYS A 63 -27.811 -0.197 26.818 1.00 93.28 C \\\\nATOM 468 C LYS A 63 -27.486 0.430 25.467 1.00 93.28 C \\\\nATOM 469 CB LYS A 63 -27.437 0.728 27.983 1.00 93.28 C \\\\nATOM 470 O LYS A 63 -28.412 0.847 24.775 1.00 93.28 O \\\\nATOM 471 CG LYS A 63 -28.233 2.040 27.961 1.00 93.28 C \\\\nATOM 472 CD LYS A 63 -27.803 2.920 29.138 1.00 93.28 C \\\\nATOM 473 CE LYS A 63 -28.577 4.240 29.125 1.00 93.28 C \\\\nATOM 474 NZ LYS A 63 -28.150 5.106 30.250 1.00 93.28 N \\\\nATOM 475 N ALA A 64 -26.217 0.479 25.066 1.00 93.52 N \\\\nATOM 476 CA ALA A 64 -25.806 1.046 23.784 1.00 93.52 C \\\\nATOM 477 C ALA A 64 -26.443 0.309 22.596 1.00 93.52 C \\\\nATOM 478 CB ALA A 64 -24.277 1.032 23.700 1.00 93.52 C \\\\nATOM 479 O ALA A 64 -27.006 0.953 21.716 1.00 93.52 O \\\\nATOM 480 N ILE A 65 -26.426 -1.029 22.605 1.00 93.03 N \\\\nATOM 481 CA ILE A 65 -27.017 -1.851 21.537 1.00 93.03 C \\\\nATOM 482 C ILE A 65 -28.545 -1.735 21.510 1.00 93.03 C \\\\nATOM 483 CB ILE A 65 -26.532 -3.315 21.639 1.00 93.03 C \\\\nATOM 484 O ILE A 65 -29.130 -1.622 20.437 1.00 93.03 O \\\\nATOM 485 CG1 ILE A 65 -25.006 -3.390 21.390 1.00 93.03 C \\\\nATOM 486 CG2 ILE A 65 -27.264 -4.212 20.620 1.00 93.03 C \\\\nATOM 487 CD1 ILE A 65 -24.401 -4.746 21.764 1.00 93.03 C \\\\nATOM 488 N THR A 66 -29.194 -1.718 22.676 1.00 92.60 N \\\\nATOM 489 CA THR A 66 -30.662 -1.653 22.763 1.00 92.60 C \\\\nATOM 490 C THR A 66 -31.198 -0.273 22.379 1.00 92.60 C \\\\nATOM 491 CB THR A 66 -31.146 -2.028 24.174 1.00 92.60 C \\\\nATOM 492 O THR A 66 -32.177 -0.171 21.647 1.00 92.60 O \\\\nATOM 493 CG2 THR A 66 -32.667 -2.135 24.269 1.00 92.60 C \\\\nATOM 494 OG1 THR A 66 -30.633 -3.284 24.551 1.00 92.60 O \\\\nATOM 495 N THR A 67 -30.559 0.797 22.863 1.00 92.64 N \\\\nATOM 496 CA THR A 67 -31.003 2.185 22.623 1.00 92.64 C \\\\nATOM 497 C THR A 67 -30.495 2.773 21.314 1.00 92.64 C \\\\nATOM 498 CB THR A 67 -30.606 3.133 23.765 1.00 92.64 C \\\\nATOM 499 O THR A 67 -31.008 3.799 20.880 1.00 92.64 O \\\\nATOM 500 CG2 THR A 67 -31.188 2.700 25.110 1.00 92.64 C \\\\nATOM 501 OG1 THR A 67 -29.206 3.215 23.915 1.00 92.64 O \\\\nATOM 502 N GLN A 68 -29.488 2.148 20.700 1.00 91.97 N \\\\nATOM 503 CA GLN A 68 -28.839 2.620 19.478 1.00 91.97 C \\\\nATOM 504 C GLN A 68 -28.338 4.071 19.573 1.00 91.97 C \\\\nATOM 505 CB GLN A 68 -29.736 2.359 18.258 1.00 91.97 C \\\\nATOM 506 O GLN A 68 -28.393 4.832 18.609 1.00 91.97 O \\\\nATOM 507 CG GLN A 68 -30.251 0.912 18.216 1.00 91.97 C \\\\nATOM 508 CD GLN A 68 -30.759 0.500 16.843 1.00 91.97 C \\\\nATOM 509 NE2 GLN A 68 -31.744 -0.367 16.782 1.00 91.97 N \\\\nATOM 510 OE1 GLN A 68 -30.267 0.904 15.800 1.00 91.97 O \\\\nATOM 511 N ASN A 69 -27.872 4.466 20.760 1.00 89.65 N \\\\nATOM 512 CA ASN A 69 -27.577 5.856 21.090 1.00 89.65 C \\\\nATOM 513 C ASN A 69 -26.068 6.099 21.251 1.00 89.65 C \\\\nATOM 514 CB ASN A 69 -28.402 6.229 22.331 1.00 89.65 C \\\\nATOM 515 O ASN A 69 -25.402 5.468 22.080 1.00 89.65 O \\\\nATOM 516 CG ASN A 69 -28.392 7.714 22.640 1.00 89.65 C \\\\nATOM 517 ND2 ASN A 69 -29.345 8.179 23.410 1.00 89.65 N \\\\nATOM 518 OD1 ASN A 69 -27.539 8.474 22.219 1.00 89.65 O \\\\nATOM 519 N CYS A 70 -25.540 7.065 20.499 1.00 90.18 N \\\\nATOM 520 CA CYS A 70 -24.140 7.490 20.554 1.00 90.18 C \\\\nATOM 521 C CYS A 70 -23.754 8.189 21.873 1.00 90.18 C \\\\nATOM 522 CB CYS A 70 -23.859 8.383 19.337 1.00 90.18 C \\\\nATOM 523 O CYS A 70 -22.586 8.165 22.245 1.00 90.18 O \\\\nATOM 524 SG CYS A 70 -24.988 9.806 19.301 1.00 90.18 S \\\\nATOM 525 N ASN A 71 -24.720 8.727 22.625 1.00 91.25 N \\\\nATOM 526 CA ASN A 71 -24.501 9.393 23.918 1.00 91.25 C \\\\nATOM 527 C ASN A 71 -24.326 8.416 25.098 1.00 91.25 C \\\\nATOM 528 CB ASN A 71 -25.653 10.379 24.174 1.00 91.25 C \\\\nATOM 529 O ASN A 71 -24.219 8.830 26.252 1.00 91.25 O \\\\nATOM 530 CG ASN A 71 -25.709 11.485 23.138 1.00 91.25 C \\\\nATOM 531 ND2 ASN A 71 -26.879 11.845 22.666 1.00 91.25 N \\\\nATOM 532 OD1 ASN A 71 -24.702 12.045 22.745 1.00 91.25 O \\\\nATOM 533 N THR A 72 -24.336 7.107 24.840 1.00 92.41 N \\\\nATOM 534 CA THR A 72 -23.986 6.097 25.850 1.00 92.41 C \\\\nATOM 535 C THR A 72 -22.507 6.193 26.239 1.00 92.41 C \\\\nATOM 536 CB THR A 72 -24.354 4.682 25.377 1.00 92.41 C \\\\nATOM 537 O THR A 72 -21.696 6.758 25.505 1.00 92.41 O \\\\nATOM 538 CG2 THR A 72 -25.874 4.478 25.331 1.00 92.41 C \\\\nATOM 539 OG1 THR A 72 -23.835 4.411 24.093 1.00 92.41 O \\\\nATOM 540 N LYS A 73 -22.125 5.663 27.410 1.00 93.98 N \\\\nATOM 541 CA LYS A 73 -20.726 5.719 27.862 1.00 93.98 C \\\\nATOM 542 C LYS A 73 -19.822 4.856 26.976 1.00 93.98 C \\\\nATOM 543 CB LYS A 73 -20.611 5.312 29.339 1.00 93.98 C \\\\nATOM 544 O LYS A 73 -20.266 3.904 26.332 1.00 93.98 O \\\\nATOM 545 CG LYS A 73 -21.291 6.319 30.278 1.00 93.98 C \\\\nATOM 546 CD LYS A 73 -21.077 5.906 31.737 1.00 93.98 C \\\\nATOM 547 CE LYS A 73 -21.893 6.794 32.679 1.00 93.98 C \\\\nATOM 548 NZ LYS A 73 -21.996 6.174 34.021 1.00 93.98 N \\\\nATOM 549 N CYS A 74 -18.523 5.163 26.980 1.00 94.08 N \\\\nATOM 550 CA CYS A 74 -17.531 4.311 26.328 1.00 94.08 C \\\\nATOM 551 C CYS A 74 -17.552 2.905 26.948 1.00 94.08 C \\\\nATOM 552 CB CYS A 74 -16.129 4.936 26.412 1.00 94.08 C \\\\nATOM 553 O CYS A 74 -17.532 2.745 28.173 1.00 94.08 O \\\\nATOM 554 SG CYS A 74 -16.008 6.429 25.382 1.00 94.08 S \\\\nATOM 555 N VAL A 75 -17.562 1.888 26.088 1.00 94.76 N \\\\nATOM 556 CA VAL A 75 -17.382 0.483 26.468 1.00 94.76 C \\\\nATOM 557 C VAL A 75 -15.969 0.112 26.067 1.00 94.76 C \\\\nATOM 558 CB VAL A 75 -18.406 -0.431 25.770 1.00 94.76 C \\\\nATOM 559 O VAL A 75 -15.702 -0.009 24.878 1.00 94.76 O \\\\nATOM 560 CG1 VAL A 75 -18.184 -1.901 26.146 1.00 94.76 C \\\\nATOM 561 CG2 VAL A 75 -19.841 -0.057 26.150 1.00 94.76 C \\\\nATOM 562 N THR A 76 -15.059 -0.032 27.023 1.00 93.46 N \\\\nATOM 563 CA THR A 76 -13.633 -0.205 26.735 1.00 93.46 C \\\\nATOM 564 C THR A 76 -13.158 -1.636 26.965 1.00 93.46 C \\\\nATOM 565 CB THR A 76 -12.778 0.807 27.509 1.00 93.46 C \\\\nATOM 566 O THR A 76 -13.692 -2.372 27.801 1.00 93.46 O \\\\nATOM 567 CG2 THR A 76 -13.114 2.240 27.106 1.00 93.46 C \\\\nATOM 568 OG1 THR A 76 -12.960 0.698 28.899 1.00 93.46 O \\\\nATOM 569 N ILE A 77 -12.156 -2.050 26.189 1.00 90.10 N \\\\nATOM 570 CA ILE A 77 -11.353 -3.243 26.468 1.00 90.10 C \\\\nATOM 571 C ILE A 77 -9.863 -2.894 26.371 1.00 90.10 C \\\\nATOM 572 CB ILE A 77 -11.712 -4.433 25.550 1.00 90.10 C \\\\nATOM 573 O ILE A 77 -9.518 -2.003 25.590 1.00 90.10 O \\\\nATOM 574 CG1 ILE A 77 -11.311 -4.212 24.075 1.00 90.10 C \\\\nATOM 575 CG2 ILE A 77 -13.194 -4.824 25.678 1.00 90.10 C \\\\nATOM 576 CD1 ILE A 77 -11.446 -5.492 23.246 1.00 90.10 C \\\\nATOM 577 N PRO A 78 -8.974 -3.630 27.063 1.00 85.17 N \\\\nATOM 578 CA PRO A 78 -7.536 -3.446 26.912 1.00 85.17 C \\\\nATOM 579 C PRO A 78 -7.113 -3.584 25.447 1.00 85.17 C \\\\nATOM 580 CB PRO A 78 -6.879 -4.504 27.802 1.00 85.17 C \\\\nATOM 581 O PRO A 78 -7.439 -4.582 24.787 1.00 85.17 O \\\\nATOM 582 CG PRO A 78 -7.942 -4.768 28.866 1.00 85.17 C \\\\nATOM 583 CD PRO A 78 -9.253 -4.611 28.100 1.00 85.17 C \\\\nATOM 584 N SER A 79 -6.401 -2.580 24.949 1.00 71.62 N \\\\nATOM 585 CA SER A 79 -5.681 -2.636 23.687 1.00 71.62 C \\\\nATOM 586 C SER A 79 -4.462 -3.539 23.896 1.00 71.62 C \\\\nATOM 587 CB SER A 79 -5.308 -1.217 23.219 1.00 71.62 C \\\\nATOM 588 O SER A 79 -3.763 -3.440 24.900 1.00 71.62 O \\\\nATOM 589 OG SER A 79 -4.110 -0.770 23.807 1.00 71.62 O \\\\nATOM 590 N THR A 80 -4.172 -4.464 22.983 1.00 59.90 N \\\\nATOM 591 CA THR A 80 -2.960 -5.301 23.097 1.00 59.90 C \\\\nATOM 592 C THR A 80 -1.685 -4.537 22.707 1.00 59.90 C \\\\nATOM 593 CB THR A 80 -3.101 -6.618 22.320 1.00 59.90 C \\\\nATOM 594 O THR A 80 -0.674 -5.158 22.406 1.00 59.90 O \\\\nATOM 595 CG2 THR A 80 -4.223 -7.497 22.877 1.00 59.90 C \\\\nATOM 596 OG1 THR A 80 -3.398 -6.369 20.967 1.00 59.90 O \\\\nATOM 597 N CYS A 81 -1.736 -3.200 22.677 1.00 47.74 N \\\\nATOM 598 CA CYS A 81 -0.661 -2.323 22.214 1.00 47.74 C \\\\nATOM 599 C CYS A 81 0.280 -1.863 23.350 1.00 47.74 C \\\\nATOM 600 CB CYS A 81 -1.319 -1.126 21.503 1.00 47.74 C \\\\nATOM 601 O CYS A 81 1.355 -1.333 23.082 1.00 47.74 O \\\\nATOM 602 SG CYS A 81 -0.392 -0.705 20.001 1.00 47.74 S \\\\nATOM 603 N SER A 82 -0.104 -2.063 24.615 1.00 37.47 N \\\\nATOM 604 CA SER A 82 0.460 -1.334 25.764 1.00 37.47 C \\\\nATOM 605 C SER A 82 1.840 -1.773 26.281 1.00 37.47 C \\\\nATOM 606 CB SER A 82 -0.560 -1.324 26.906 1.00 37.47 C \\\\nATOM 607 O SER A 82 2.295 -1.221 27.273 1.00 37.47 O \\\\nATOM 608 OG SER A 82 -1.732 -0.678 26.466 1.00 37.47 O \\\\nATOM 609 N GLU A 83 2.556 -2.707 25.645 1.00 31.77 N \\\\nATOM 610 CA GLU A 83 3.882 -3.150 26.139 1.00 31.77 C \\\\nATOM 611 C GLU A 83 5.094 -2.591 25.370 1.00 31.77 C \\\\nATOM 612 CB GLU A 83 3.915 -4.680 26.315 1.00 31.77 C \\\\nATOM 613 O GLU A 83 6.224 -2.919 25.710 1.00 31.77 O \\\\nATOM 614 CG GLU A 83 3.294 -5.082 27.666 1.00 31.77 C \\\\nATOM 615 CD GLU A 83 3.256 -6.598 27.899 1.00 31.77 C \\\\nATOM 616 OE1 GLU A 83 2.828 -7.025 29.001 1.00 31.77 O \\\\nATOM 617 OE2 GLU A 83 3.452 -7.382 26.936 1.00 31.77 O \\\\nATOM 618 N ILE A 84 4.906 -1.712 24.376 1.00 36.42 N \\\\nATOM 619 CA ILE A 84 6.024 -1.180 23.555 1.00 36.42 C \\\\nATOM 620 C ILE A 84 6.279 0.324 23.782 1.00 36.42 C \\\\nATOM 621 CB ILE A 84 5.843 -1.596 22.072 1.00 36.42 C \\\\nATOM 622 O ILE A 84 7.289 0.856 23.338 1.00 36.42 O \\\\nATOM 623 CG1 ILE A 84 5.726 -3.139 21.977 1.00 36.42 C \\\\nATOM 624 CG2 ILE A 84 6.992 -1.116 21.162 1.00 36.42 C \\\\nATOM 625 CD1 ILE A 84 5.420 -3.649 20.568 1.00 36.42 C \\\\nATOM 626 N TRP A 85 5.426 1.014 24.546 1.00 34.71 N \\\\nATOM 627 CA TRP A 85 5.549 2.464 24.793 1.00 34.71 C \\\\nATOM 628 C TRP A 85 5.761 2.828 26.271 1.00 34.71 C \\\\nATOM 629 CB TRP A 85 4.381 3.188 24.113 1.00 34.71 C \\\\nATOM 630 O TRP A 85 5.601 3.981 26.669 1.00 34.71 O \\\\nATOM 631 CG TRP A 85 4.342 2.970 22.629 1.00 34.71 C \\\\nATOM 632 CD1 TRP A 85 3.536 2.101 21.977 1.00 34.71 C \\\\nATOM 633 CD2 TRP A 85 5.203 3.561 21.607 1.00 34.71 C \\\\nATOM 634 CE2 TRP A 85 4.849 3.004 20.342 1.00 34.71 C \\\\nATOM 635 CE3 TRP A 85 6.259 4.499 21.624 1.00 34.71 C \\\\nATOM 636 NE1 TRP A 85 3.833 2.116 20.628 1.00 34.71 N \\\\nATOM 637 CH2 TRP A 85 6.542 4.307 19.203 1.00 34.71 C \\\\nATOM 638 CZ2 TRP A 85 5.500 3.365 19.152 1.00 34.71 C \\\\nATOM 639 CZ3 TRP A 85 6.920 4.870 20.436 1.00 34.71 C \\\\nATOM 640 N GLY A 86 6.149 1.843 27.086 1.00 29.44 N \\\\nATOM 641 CA GLY A 86 6.509 2.026 28.486 1.00 29.44 C \\\\nATOM 642 C GLY A 86 7.871 2.694 28.626 1.00 29.44 C \\\\nATOM 643 O GLY A 86 8.901 2.051 28.456 1.00 29.44 O \\\\nATOM 644 N LEU A 87 7.829 3.989 28.932 1.00 30.48 N \\\\nATOM 645 CA LEU A 87 8.833 4.761 29.663 1.00 30.48 C \\\\nATOM 646 C LEU A 87 9.878 3.875 30.357 1.00 30.48 C \\\\nATOM 647 CB LEU A 87 8.064 5.590 30.711 1.00 30.48 C \\\\nATOM 648 O LEU A 87 9.633 3.302 31.418 1.00 30.48 O \\\\nATOM 649 CG LEU A 87 7.241 6.738 30.097 1.00 30.48 C \\\\nATOM 650 CD1 LEU A 87 6.038 7.073 30.977 1.00 30.48 C \\\\nATOM 651 CD2 LEU A 87 8.101 7.992 29.942 1.00 30.48 C \\\\nATOM 652 N SER A 88 11.063 3.814 29.760 1.00 25.22 N \\\\nATOM 653 CA SER A 88 12.293 3.451 30.440 1.00 25.22 C \\\\nATOM 654 C SER A 88 12.496 4.428 31.599 1.00 25.22 C \\\\nATOM 655 CB SER A 88 13.476 3.470 29.450 1.00 25.22 C \\\\nATOM 656 O SER A 88 12.966 5.549 31.422 1.00 25.22 O \\\\nATOM 657 OG SER A 88 13.191 4.184 28.252 1.00 25.22 O \\\\nATOM 658 N THR A 89 12.136 4.009 32.810 1.00 30.16 N \\\\nATOM 659 CA THR A 89 12.752 4.561 34.014 1.00 30.16 C \\\\nATOM 660 C THR A 89 14.230 4.167 33.984 1.00 30.16 C \\\\nATOM 661 CB THR A 89 12.091 4.035 35.295 1.00 30.16 C \\\\nATOM 662 O THR A 89 14.527 2.970 33.921 1.00 30.16 O \\\\nATOM 663 CG2 THR A 89 10.757 4.732 35.552 1.00 30.16 C \\\\nATOM 664 OG1 THR A 89 11.841 2.651 35.201 1.00 30.16 O \\\\nATOM 665 N PRO A 90 15.173 5.124 34.002 1.00 28.90 N \\\\nATOM 666 CA PRO A 90 16.584 4.803 34.088 1.00 28.90 C \\\\nATOM 667 C PRO A 90 16.835 4.377 35.529 1.00 28.90 C \\\\nATOM 668 CB PRO A 90 17.313 6.095 33.707 1.00 28.90 C \\\\nATOM 669 O PRO A 90 16.705 5.202 36.424 1.00 28.90 O \\\\nATOM 670 CG PRO A 90 16.362 7.203 34.168 1.00 28.90 C \\\\nATOM 671 CD PRO A 90 14.973 6.563 34.105 1.00 28.90 C \\\\nATOM 672 N ASN A 91 17.056 3.084 35.752 1.00 29.36 N \\\\nATOM 673 CA ASN A 91 17.805 2.494 36.867 1.00 29.36 C \\\\nATOM 674 C ASN A 91 17.425 1.019 36.949 1.00 29.36 C \\\\nATOM 675 CB ASN A 91 17.552 3.179 38.232 1.00 29.36 C \\\\nATOM 676 O ASN A 91 16.373 0.683 37.484 1.00 29.36 O \\\\nATOM 677 CG ASN A 91 18.396 4.431 38.428 1.00 29.36 C \\\\nATOM 678 ND2 ASN A 91 18.022 5.292 39.346 1.00 29.36 N \\\\nATOM 679 OD1 ASN A 91 19.401 4.654 37.771 1.00 29.36 O \\\\nATOM 680 N THR A 92 18.254 0.164 36.353 1.00 32.37 N \\\\nATOM 681 CA THR A 92 18.830 -1.072 36.920 1.00 32.37 C \\\\nATOM 682 C THR A 92 19.379 -1.865 35.730 1.00 32.37 C \\\\nATOM 683 CB THR A 92 17.909 -1.961 37.789 1.00 32.37 C \\\\nATOM 684 O THR A 92 18.694 -2.679 35.117 1.00 32.37 O \\\\nATOM 685 CG2 THR A 92 18.737 -3.005 38.536 1.00 32.37 C \\\\nATOM 686 OG1 THR A 92 17.303 -1.246 38.836 1.00 32.37 O \\\\nATOM 687 N ILE A 93 20.615 -1.541 35.349 1.00 28.03 N \\\\nATOM 688 CA ILE A 93 21.522 -2.503 34.722 1.00 28.03 C \\\\nATOM 689 C ILE A 93 21.924 -3.445 35.857 1.00 28.03 C \\\\nATOM 690 CB ILE A 93 22.731 -1.736 34.106 1.00 28.03 C \\\\nATOM 691 O ILE A 93 22.379 -2.948 36.879 1.00 28.03 O \\\\nATOM 692 CG1 ILE A 93 22.439 -1.434 32.620 1.00 28.03 C \\\\nATOM 693 CG2 ILE A 93 24.089 -2.445 34.256 1.00 28.03 C \\\\nATOM 694 CD1 ILE A 93 23.420 -0.446 31.969 1.00 28.03 C \\\\nATOM 695 N ASP A 94 21.669 -4.747 35.726 1.00 28.87 N \\\\nATOM 696 CA ASP A 94 22.699 -5.776 35.917 1.00 28.87 C \\\\nATOM 697 C ASP A 94 22.152 -7.210 35.825 1.00 28.87 C \\\\nATOM 698 CB ASP A 94 23.527 -5.601 37.216 1.00 28.87 C \\\\nATOM 699 O ASP A 94 21.021 -7.503 36.202 1.00 28.87 O \\\\nATOM 700 CG ASP A 94 24.797 -4.765 36.982 1.00 28.87 C \\\\nATOM 701 OD1 ASP A 94 25.372 -4.904 35.874 1.00 28.87 O \\\\nATOM 702 OD2 ASP A 94 25.229 -4.050 37.912 1.00 28.87 O \\\\nATOM 703 N GLN A 95 23.048 -8.084 35.356 1.00 28.34 N \\\\nATOM 704 CA GLN A 95 23.051 -9.550 35.431 1.00 28.34 C \\\\nATOM 705 C GLN A 95 22.244 -10.349 34.398 1.00 28.34 C \\\\nATOM 706 CB GLN A 95 22.909 -10.039 36.878 1.00 28.34 C \\\\nATOM 707 O GLN A 95 21.122 -10.808 34.592 1.00 28.34 O \\\\nATOM 708 CG GLN A 95 24.224 -9.778 37.628 1.00 28.34 C \\\\nATOM 709 CD GLN A 95 24.151 -10.082 39.115 1.00 28.34 C \\\\nATOM 710 NE2 GLN A 95 25.259 -9.974 39.813 1.00 28.34 N \\\\nATOM 711 OE1 GLN A 95 23.125 -10.391 39.695 1.00 28.34 O \\\\nATOM 712 N TRP A 96 22.942 -10.621 33.298 1.00 28.28 N \\\\nATOM 713 CA TRP A 96 22.775 -11.798 32.453 1.00 28.28 C \\\\nATOM 714 C TRP A 96 23.284 -13.016 33.228 1.00 28.28 C \\\\nATOM 715 CB TRP A 96 23.558 -11.586 31.132 1.00 28.28 C \\\\nATOM 716 O TRP A 96 24.493 -13.222 33.312 1.00 28.28 O \\\\nATOM 717 CG TRP A 96 24.418 -10.350 31.070 1.00 28.28 C \\\\nATOM 718 CD1 TRP A 96 23.944 -9.116 30.787 1.00 28.28 C \\\\nATOM 719 CD2 TRP A 96 25.832 -10.165 31.407 1.00 28.28 C \\\\nATOM 720 CE2 TRP A 96 26.137 -8.773 31.296 1.00 28.28 C \\\\nATOM 721 CE3 TRP A 96 26.882 -11.012 31.826 1.00 28.28 C \\\\nATOM 722 NE1 TRP A 96 24.950 -8.184 30.923 1.00 28.28 N \\\\nATOM 723 CH2 TRP A 96 28.435 -9.124 31.956 1.00 28.28 C \\\\nATOM 724 CZ2 TRP A 96 27.409 -8.249 31.563 1.00 28.28 C \\\\nATOM 725 CZ3 TRP A 96 28.169 -10.499 32.089 1.00 28.28 C \\\\nATOM 726 N ASP A 97 22.372 -13.816 33.783 1.00 30.80 N \\\\nATOM 727 CA ASP A 97 22.724 -15.109 34.364 1.00 30.80 C \\\\nATOM 728 C ASP A 97 22.295 -16.277 33.477 1.00 30.80 C \\\\nATOM 729 CB ASP A 97 22.293 -15.250 35.836 1.00 30.80 C \\\\nATOM 730 O ASP A 97 21.179 -16.376 32.964 1.00 30.80 O \\\\nATOM 731 CG ASP A 97 23.484 -15.319 36.808 1.00 30.80 C \\\\nATOM 732 OD1 ASP A 97 24.590 -15.712 36.366 1.00 30.80 O \\\\nATOM 733 OD2 ASP A 97 23.262 -15.039 38.003 1.00 30.80 O \\\\nATOM 734 N THR A 98 23.271 -17.153 33.269 1.00 31.38 N \\\\nATOM 735 CA THR A 98 23.314 -18.206 32.260 1.00 31.38 C \\\\nATOM 736 C THR A 98 22.985 -19.534 32.926 1.00 31.38 C \\\\nATOM 737 CB THR A 98 24.722 -18.229 31.618 1.00 31.38 C \\\\nATOM 738 O THR A 98 23.879 -20.339 33.113 1.00 31.38 O \\\\nATOM 739 CG2 THR A 98 24.846 -19.152 30.402 1.00 31.38 C \\\\nATOM 740 OG1 THR A 98 25.071 -16.945 31.158 1.00 31.38 O \\\\nATOM 741 N THR A 99 21.741 -19.796 33.338 1.00 33.23 N \\\\nATOM 742 CA THR A 99 21.313 -21.157 33.728 1.00 33.23 C \\\\nATOM 743 C THR A 99 19.787 -21.311 33.746 1.00 33.23 C \\\\nATOM 744 CB THR A 99 21.846 -21.623 35.107 1.00 33.23 C \\\\nATOM 745 O THR A 99 19.082 -20.562 34.402 1.00 33.23 O \\\\nATOM 746 CG2 THR A 99 23.257 -22.219 35.127 1.00 33.23 C \\\\nATOM 747 OG1 THR A 99 21.824 -20.599 36.064 1.00 33.23 O \\\\nATOM 748 N GLY A 100 19.296 -22.335 33.041 1.00 27.30 N \\\\nATOM 749 CA GLY A 100 18.237 -23.241 33.502 1.00 27.30 C \\\\nATOM 750 C GLY A 100 16.857 -22.696 33.906 1.00 27.30 C \\\\nATOM 751 O GLY A 100 16.671 -22.157 34.986 1.00 27.30 O \\\\nATOM 752 N LEU A 101 15.853 -23.125 33.132 1.00 27.46 N \\\\nATOM 753 CA LEU A 101 14.538 -23.565 33.627 1.00 27.46 C \\\\nATOM 754 C LEU A 101 13.613 -22.492 34.228 1.00 27.46 C \\\\nATOM 755 CB LEU A 101 14.733 -24.746 34.612 1.00 27.46 C \\\\nATOM 756 O LEU A 101 13.380 -22.483 35.428 1.00 27.46 O \\\\nATOM 757 CG LEU A 101 15.334 -26.022 34.005 1.00 27.46 C \\\\nATOM 758 CD1 LEU A 101 15.954 -26.888 35.100 1.00 27.46 C \\\\nATOM 759 CD2 LEU A 101 14.255 -26.838 33.290 1.00 27.46 C \\\\nATOM 760 N TYR A 102 12.916 -21.736 33.373 1.00 30.22 N \\\\nATOM 761 CA TYR A 102 11.531 -21.351 33.669 1.00 30.22 C \\\\nATOM 762 C TYR A 102 10.646 -21.485 32.430 1.00 30.22 C \\\\nATOM 763 CB TYR A 102 11.414 -19.976 34.345 1.00 30.22 C \\\\nATOM 764 O TYR A 102 10.863 -20.877 31.385 1.00 30.22 O \\\\nATOM 765 CG TYR A 102 11.474 -20.073 35.861 1.00 30.22 C \\\\nATOM 766 CD1 TYR A 102 10.316 -20.404 36.597 1.00 30.22 C \\\\nATOM 767 CD2 TYR A 102 12.702 -19.909 36.528 1.00 30.22 C \\\\nATOM 768 CE1 TYR A 102 10.395 -20.584 37.993 1.00 30.22 C \\\\nATOM 769 CE2 TYR A 102 12.789 -20.106 37.919 1.00 30.22 C \\\\nATOM 770 OH TYR A 102 11.715 -20.639 39.995 1.00 30.22 O \\\\nATOM 771 CZ TYR A 102 11.635 -20.446 38.653 1.00 30.22 C \\\\nATOM 772 N SER A 103 9.636 -22.332 32.579 1.00 24.84 N \\\\nATOM 773 CA SER A 103 8.519 -22.529 31.672 1.00 24.84 C \\\\nATOM 774 C SER A 103 7.653 -21.269 31.646 1.00 24.84 C \\\\nATOM 775 CB SER A 103 7.727 -23.752 32.167 1.00 24.84 C \\\\nATOM 776 O SER A 103 6.948 -20.964 32.604 1.00 24.84 O \\\\nATOM 777 OG SER A 103 7.608 -23.765 33.584 1.00 24.84 O \\\\nATOM 778 N PHE A 104 7.684 -20.532 30.536 1.00 27.44 N \\\\nATOM 779 CA PHE A 104 6.739 -19.449 30.283 1.00 27.44 C \\\\nATOM 780 C PHE A 104 5.822 -19.864 29.138 1.00 27.44 C \\\\nATOM 781 CB PHE A 104 7.459 -18.110 30.061 1.00 27.44 C \\\\nATOM 782 O PHE A 104 6.258 -20.127 28.023 1.00 27.44 O \\\\nATOM 783 CG PHE A 104 6.856 -16.986 30.884 1.00 27.44 C \\\\nATOM 784 CD1 PHE A 104 5.896 -16.119 30.327 1.00 27.44 C \\\\nATOM 785 CD2 PHE A 104 7.246 -16.822 32.227 1.00 27.44 C \\\\nATOM 786 CE1 PHE A 104 5.346 -15.083 31.105 1.00 27.44 C \\\\nATOM 787 CE2 PHE A 104 6.696 -15.788 33.004 1.00 27.44 C \\\\nATOM 788 CZ PHE A 104 5.749 -14.915 32.443 1.00 27.44 C \\\\nATOM 789 N SER A 105 4.533 -19.978 29.442 1.00 27.30 N \\\\nATOM 790 CA SER A 105 3.481 -20.297 28.485 1.00 27.30 C \\\\nATOM 791 C SER A 105 3.463 -19.278 27.338 1.00 27.30 C \\\\nATOM 792 CB SER A 105 2.141 -20.303 29.231 1.00 27.30 C \\\\nATOM 793 O SER A 105 3.019 -18.142 27.521 1.00 27.30 O \\\\nATOM 794 OG SER A 105 1.982 -19.098 29.958 1.00 27.30 O \\\\nATOM 795 N GLU A 106 3.917 -19.692 26.156 1.00 25.42 N \\\\nATOM 796 CA GLU A 106 3.860 -18.921 24.914 1.00 25.42 C \\\\nATOM 797 C GLU A 106 2.403 -18.745 24.448 1.00 25.42 C \\\\nATOM 798 CB GLU A 106 4.702 -19.607 23.823 1.00 25.42 C \\\\nATOM 799 O GLU A 106 1.842 -19.550 23.706 1.00 25.42 O \\\\nATOM 800 CG GLU A 106 6.214 -19.418 24.009 1.00 25.42 C \\\\nATOM 801 CD GLU A 106 7.009 -20.112 22.892 1.00 25.42 C \\\\nATOM 802 OE1 GLU A 106 7.955 -19.480 22.375 1.00 25.42 O \\\\nATOM 803 OE2 GLU A 106 6.631 -21.253 22.542 1.00 25.42 O \\\\nATOM 804 N GLN A 107 1.765 -17.653 24.872 1.00 28.28 N \\\\nATOM 805 CA GLN A 107 0.642 -17.059 24.146 1.00 28.28 C \\\\nATOM 806 C GLN A 107 1.187 -15.917 23.290 1.00 28.28 C \\\\nATOM 807 CB GLN A 107 -0.488 -16.621 25.098 1.00 28.28 C \\\\nATOM 808 O GLN A 107 1.437 -14.817 23.774 1.00 28.28 O \\\\nATOM 809 CG GLN A 107 -1.620 -17.657 25.091 1.00 28.28 C \\\\nATOM 810 CD GLN A 107 -2.763 -17.340 26.051 1.00 28.28 C \\\\nATOM 811 NE2 GLN A 107 -3.799 -18.150 26.062 1.00 28.28 N \\\\nATOM 812 OE1 GLN A 107 -2.782 -16.380 26.803 1.00 28.28 O \\\\nATOM 813 N THR A 108 1.370 -16.198 22.003 1.00 28.45 N \\\\nATOM 814 CA THR A 108 1.763 -15.256 20.948 1.00 28.45 C \\\\nATOM 815 C THR A 108 0.865 -14.004 20.952 1.00 28.45 C \\\\nATOM 816 CB THR A 108 1.719 -15.973 19.575 1.00 28.45 C \\\\nATOM 817 O THR A 108 -0.259 -14.024 20.446 1.00 28.45 O \\\\nATOM 818 CG2 THR A 108 3.096 -16.467 19.142 1.00 28.45 C \\\\nATOM 819 OG1 THR A 108 0.905 -17.134 19.580 1.00 28.45 O \\\\nATOM 820 N ARG A 109 1.351 -12.899 21.542 1.00 34.15 N \\\\nATOM 821 CA ARG A 109 0.684 -11.581 21.578 1.00 34.15 C \\\\nATOM 822 C ARG A 109 0.880 -10.832 20.252 1.00 34.15 C \\\\nATOM 823 CB ARG A 109 1.190 -10.740 22.773 1.00 34.15 C \\\\nATOM 824 O ARG A 109 1.962 -10.830 19.675 1.00 34.15 O \\\\nATOM 825 CG ARG A 109 0.662 -11.219 24.138 1.00 34.15 C \\\\nATOM 826 CD ARG A 109 1.170 -10.320 25.277 1.00 34.15 C \\\\nATOM 827 NE ARG A 109 0.667 -10.750 26.600 1.00 34.15 N \\\\nATOM 828 NH1 ARG A 109 1.439 -8.933 27.757 1.00 34.15 N \\\\nATOM 829 NH2 ARG A 109 0.374 -10.503 28.864 1.00 34.15 N \\\\nATOM 830 CZ ARG A 109 0.826 -10.067 27.724 1.00 34.15 C \\\\nATOM 831 N SER A 110 -0.182 -10.209 19.747 1.00 40.36 N \\\\nATOM 832 CA SER A 110 -0.188 -9.347 18.556 1.00 40.36 C \\\\nATOM 833 C SER A 110 0.285 -7.932 18.902 1.00 40.36 C \\\\nATOM 834 CB SER A 110 -1.599 -9.285 17.940 1.00 40.36 C \\\\nATOM 835 O SER A 110 -0.391 -7.226 19.647 1.00 40.36 O \\\\nATOM 836 OG SER A 110 -2.593 -9.587 18.901 1.00 40.36 O \\\\nATOM 837 N LEU A 111 1.410 -7.521 18.308 1.00 46.85 N \\\\nATOM 838 CA LEU A 111 2.098 -6.232 18.510 1.00 46.85 C \\\\nATOM 839 C LEU A 111 1.354 -5.012 17.914 1.00 46.85 C \\\\nATOM 840 CB LEU A 111 3.521 -6.342 17.906 1.00 46.85 C \\\\nATOM 841 O LEU A 111 1.835 -3.891 18.007 1.00 46.85 O \\\\nATOM 842 CG LEU A 111 4.412 -7.471 18.467 1.00 46.85 C \\\\nATOM 843 CD1 LEU A 111 5.636 -7.678 17.575 1.00 46.85 C \\\\nATOM 844 CD2 LEU A 111 4.914 -7.198 19.881 1.00 46.85 C \\\\nATOM 845 N ASP A 112 0.196 -5.213 17.281 1.00 55.73 N \\\\nATOM 846 CA ASP A 112 -0.514 -4.217 16.466 1.00 55.73 C \\\\nATOM 847 C ASP A 112 -1.930 -3.883 16.980 1.00 55.73 C \\\\nATOM 848 CB ASP A 112 -0.510 -4.692 15.001 1.00 55.73 C \\\\nATOM 849 O ASP A 112 -2.784 -3.407 16.231 1.00 55.73 O \\\\nATOM 850 CG ASP A 112 -1.314 -5.975 14.740 1.00 55.73 C \\\\nATOM 851 OD1 ASP A 112 -1.678 -6.702 15.700 1.00 55.73 O \\\\nATOM 852 OD2 ASP A 112 -1.580 -6.257 13.548 1.00 55.73 O \\\\nATOM 853 N GLY A 113 -2.224 -4.171 18.253 1.00 59.81 N \\\\nATOM 854 CA GLY A 113 -3.535 -3.895 18.857 1.00 59.81 C \\\\nATOM 855 C GLY A 113 -4.675 -4.818 18.389 1.00 59.81 C \\\\nATOM 856 O GLY A 113 -5.836 -4.599 18.750 1.00 59.81 O \\\\nATOM 857 N ARG A 114 -4.391 -5.854 17.582 1.00 63.47 N \\\\nATOM 858 CA ARG A 114 -5.409 -6.800 17.093 1.00 63.47 C \\\\nATOM 859 C ARG A 114 -5.798 -7.824 18.152 1.00 63.47 C \\\\nATOM 860 CB ARG A 114 -4.942 -7.495 15.809 1.00 63.47 C \\\\nATOM 861 O ARG A 114 -4.953 -8.455 18.775 1.00 63.47 O \\\\nATOM 862 CG ARG A 114 -4.841 -6.507 14.643 1.00 63.47 C \\\\nATOM 863 CD ARG A 114 -4.440 -7.238 13.362 1.00 63.47 C \\\\nATOM 864 NE ARG A 114 -4.171 -6.273 12.286 1.00 63.47 N \\\\nATOM 865 NH1 ARG A 114 -3.462 -7.784 10.712 1.00 63.47 N \\\\nATOM 866 NH2 ARG A 114 -3.261 -5.593 10.321 1.00 63.47 N \\\\nATOM 867 CZ ARG A 114 -3.634 -6.555 11.116 1.00 63.47 C \\\\nATOM 868 N LEU A 115 -7.096 -8.079 18.277 1.00 74.63 N \\\\nATOM 869 CA LEU A 115 -7.659 -9.174 19.058 1.00 74.63 C \\\\nATOM 870 C LEU A 115 -7.690 -10.461 18.228 1.00 74.63 C \\\\nATOM 871 CB LEU A 115 -9.063 -8.754 19.520 1.00 74.63 C \\\\nATOM 872 O LEU A 115 -8.206 -10.474 17.111 1.00 74.63 O \\\\nATOM 873 CG LEU A 115 -9.828 -9.795 20.351 1.00 74.63 C \\\\nATOM 874 CD1 LEU A 115 -9.130 -10.049 21.690 1.00 74.63 C \\\\nATOM 875 CD2 LEU A 115 -11.243 -9.286 20.637 1.00 74.63 C \\\\nATOM 876 N GLN A 116 -7.198 -11.560 18.799 1.00 75.91 N \\\\nATOM 877 CA GLN A 116 -7.332 -12.890 18.211 1.00 75.91 C \\\\nATOM 878 C GLN A 116 -8.573 -13.606 18.758 1.00 75.91 C \\\\nATOM 879 CB GLN A 116 -6.034 -13.680 18.419 1.00 75.91 C \\\\nATOM 880 O GLN A 116 -8.695 -13.840 19.961 1.00 75.91 O \\\\nATOM 881 CG GLN A 116 -6.031 -15.028 17.672 1.00 75.91 C \\\\nATOM 882 CD GLN A 116 -4.640 -15.661 17.623 1.00 75.91 C \\\\nATOM 883 NE2 GLN A 116 -4.521 -16.957 17.437 1.00 75.91 N \\\\nATOM 884 OE1 GLN A 116 -3.625 -14.996 17.701 1.00 75.91 O \\\\nATOM 885 N VAL A 117 -9.483 -13.994 17.865 1.00 72.04 N \\\\nATOM 886 CA VAL A 117 -10.655 -14.827 18.167 1.00 72.04 C \\\\nATOM 887 C VAL A 117 -10.622 -16.049 17.256 1.00 72.04 C \\\\nATOM 888 CB VAL A 117 -11.978 -14.051 17.996 1.00 72.04 C \\\\nATOM 889 O VAL A 117 -10.773 -15.928 16.043 1.00 72.04 O \\\\nATOM 890 CG1 VAL A 117 -13.165 -14.936 18.402 1.00 72.04 C \\\\nATOM 891 CG2 VAL A 117 -12.019 -12.777 18.849 1.00 72.04 C \\\\nATOM 892 N SER A 118 -10.434 -17.240 17.837 1.00 68.99 N \\\\nATOM 893 CA SER A 118 -10.448 -18.525 17.114 1.00 68.99 C \\\\nATOM 894 C SER A 118 -9.568 -18.523 15.851 1.00 68.99 C \\\\nATOM 895 CB SER A 118 -11.902 -18.925 16.820 1.00 68.99 C \\\\nATOM 896 O SER A 118 -10.045 -18.857 14.771 1.00 68.99 O \\\\nATOM 897 OG SER A 118 -12.005 -20.289 16.448 1.00 68.99 O \\\\nATOM 898 N HIS A 119 -8.298 -18.123 15.997 1.00 68.93 N \\\\nATOM 899 CA HIS A 119 -7.280 -17.992 14.933 1.00 68.93 C \\\\nATOM 900 C HIS A 119 -7.458 -16.828 13.945 1.00 68.93 C \\\\nATOM 901 CB HIS A 119 -7.038 -19.332 14.213 1.00 68.93 C \\\\nATOM 902 O HIS A 119 -6.550 -16.568 13.163 1.00 68.93 O \\\\nATOM 903 CG HIS A 119 -6.783 -20.471 15.161 1.00 68.93 C \\\\nATOM 904 CD2 HIS A 119 -7.722 -21.318 15.683 1.00 68.93 C \\\\nATOM 905 ND1 HIS A 119 -5.566 -20.833 15.692 1.00 68.93 N \\\\nATOM 906 CE1 HIS A 119 -5.772 -21.870 16.522 1.00 68.93 C \\\\nATOM 907 NE2 HIS A 119 -7.079 -22.174 16.576 1.00 68.93 N \\\\nATOM 908 N ARG A 120 -8.551 -16.058 14.018 1.00 73.52 N \\\\nATOM 909 CA ARG A 120 -8.704 -14.816 13.243 1.00 73.52 C \\\\nATOM 910 C ARG A 120 -8.238 -13.621 14.072 1.00 73.52 C \\\\nATOM 911 CB ARG A 120 -10.150 -14.654 12.750 1.00 73.52 C \\\\nATOM 912 O ARG A 120 -8.711 -13.441 15.194 1.00 73.52 O \\\\nATOM 913 CG ARG A 120 -10.598 -15.814 11.841 1.00 73.52 C \\\\nATOM 914 CD ARG A 120 -11.986 -15.551 11.237 1.00 73.52 C \\\\nATOM 915 NE ARG A 120 -12.393 -16.616 10.296 1.00 73.52 N \\\\nATOM 916 NH1 ARG A 120 -14.515 -15.835 9.841 1.00 73.52 N \\\\nATOM 917 NH2 ARG A 120 -13.766 -17.643 8.785 1.00 73.52 N \\\\nATOM 918 CZ ARG A 120 -13.550 -16.692 9.650 1.00 73.52 C \\\\nATOM 919 N LYS A 121 -7.316 -12.819 13.535 1.00 76.82 N \\\\nATOM 920 CA LYS A 121 -6.859 -11.555 14.138 1.00 76.82 C \\\\nATOM 921 C LYS A 121 -7.628 -10.391 13.514 1.00 76.82 C \\\\nATOM 922 CB LYS A 121 -5.338 -11.376 13.963 1.00 76.82 C \\\\nATOM 923 O LYS A 121 -7.679 -10.288 12.295 1.00 76.82 O \\\\nATOM 924 CG LYS A 121 -4.515 -12.378 14.792 1.00 76.82 C \\\\nATOM 925 CD LYS A 121 -3.003 -12.124 14.659 1.00 76.82 C \\\\nATOM 926 CE LYS A 121 -2.218 -13.100 15.552 1.00 76.82 C \\\\nATOM 927 NZ LYS A 121 -0.748 -12.887 15.486 1.00 76.82 N \\\\nATOM 928 N GLY A 122 -8.187 -9.507 14.332 1.00 81.47 N \\\\nATOM 929 CA GLY A 122 -8.886 -8.310 13.863 1.00 81.47 C \\\\nATOM 930 C GLY A 122 -8.894 -7.214 14.919 1.00 81.47 C \\\\nATOM 931 O GLY A 122 -8.692 -7.476 16.103 1.00 81.47 O \\\\nATOM 932 N LEU A 123 -9.103 -5.968 14.505 1.00 87.81 N \\\\nATOM 933 CA LEU A 123 -9.176 -4.849 15.442 1.00 87.81 C \\\\nATOM 934 C LEU A 123 -10.486 -4.927 16.247 1.00 87.81 C \\\\nATOM 935 CB LEU A 123 -9.035 -3.529 14.676 1.00 87.81 C \\\\nATOM 936 O LEU A 123 -11.540 -5.149 15.648 1.00 87.81 O \\\\nATOM 937 CG LEU A 123 -7.629 -3.315 14.083 1.00 87.81 C \\\\nATOM 938 CD1 LEU A 123 -7.642 -2.128 13.128 1.00 87.81 C \\\\nATOM 939 CD2 LEU A 123 -6.585 -3.067 15.172 1.00 87.81 C \\\\nATOM 940 N PRO A 124 -10.460 -4.748 17.583 1.00 91.18 N \\\\nATOM 941 CA PRO A 124 -11.645 -4.955 18.413 1.00 91.18 C \\\\nATOM 942 C PRO A 124 -12.867 -4.149 17.976 1.00 91.18 C \\\\nATOM 943 CB PRO A 124 -11.227 -4.558 19.825 1.00 91.18 C \\\\nATOM 944 O PRO A 124 -13.944 -4.708 17.804 1.00 91.18 O \\\\nATOM 945 CG PRO A 124 -9.724 -4.812 19.848 1.00 91.18 C \\\\nATOM 946 CD PRO A 124 -9.285 -4.515 18.417 1.00 91.18 C \\\\nATOM 947 N HIS A 125 -12.693 -2.846 17.760 1.00 92.35 N \\\\nATOM 948 CA HIS A 125 -13.778 -1.954 17.364 1.00 92.35 C \\\\nATOM 949 C HIS A 125 -14.386 -2.352 16.009 1.00 92.35 C \\\\nATOM 950 CB HIS A 125 -13.265 -0.512 17.371 1.00 92.35 C \\\\nATOM 951 O HIS A 125 -15.605 -2.341 15.875 1.00 92.35 O \\\\nATOM 952 CG HIS A 125 -12.171 -0.245 16.372 1.00 92.35 C \\\\nATOM 953 CD2 HIS A 125 -12.325 0.383 15.167 1.00 92.35 C \\\\nATOM 954 ND1 HIS A 125 -10.841 -0.590 16.492 1.00 92.35 N \\\\nATOM 955 CE1 HIS A 125 -10.216 -0.192 15.373 1.00 92.35 C \\\\nATOM 956 NE2 HIS A 125 -11.081 0.391 14.540 1.00 92.35 N \\\\nATOM 957 N VAL A 126 -13.568 -2.806 15.049 1.00 92.28 N \\\\nATOM 958 CA VAL A 126 -14.039 -3.320 13.750 1.00 92.28 C \\\\nATOM 959 C VAL A 126 -14.865 -4.590 13.928 1.00 92.28 C \\\\nATOM 960 CB VAL A 126 -12.871 -3.598 12.784 1.00 92.28 C \\\\nATOM 961 O VAL A 126 -15.959 -4.678 13.385 1.00 92.28 O \\\\nATOM 962 CG1 VAL A 126 -13.341 -4.074 11.404 1.00 92.28 C \\\\nATOM 963 CG2 VAL A 126 -12.036 -2.341 12.566 1.00 92.28 C \\\\nATOM 964 N ILE A 127 -14.385 -5.556 14.724 1.00 92.20 N \\\\nATOM 965 CA ILE A 127 -15.093 -6.826 14.975 1.00 92.20 C \\\\nATOM 966 C ILE A 127 -16.507 -6.566 15.506 1.00 92.20 C \\\\nATOM 967 CB ILE A 127 -14.283 -7.710 15.959 1.00 92.20 C \\\\nATOM 968 O ILE A 127 -17.475 -7.159 15.032 1.00 92.20 O \\\\nATOM 969 CG1 ILE A 127 -13.002 -8.244 15.276 1.00 92.20 C \\\\nATOM 970 CG2 ILE A 127 -15.144 -8.865 16.517 1.00 92.20 C \\\\nATOM 971 CD1 ILE A 127 -11.991 -8.869 16.249 1.00 92.20 C \\\\nATOM 972 N TYR A 128 -16.629 -5.678 16.490 1.00 94.45 N \\\\nATOM 973 CA TYR A 128 -17.897 -5.428 17.169 1.00 94.45 C \\\\nATOM 974 C TYR A 128 -18.826 -4.489 16.387 1.00 94.45 C \\\\nATOM 975 CB TYR A 128 -17.579 -4.936 18.580 1.00 94.45 C \\\\nATOM 976 O TYR A 128 -20.036 -4.712 16.376 1.00 94.45 O \\\\nATOM 977 CG TYR A 128 -16.888 -5.987 19.446 1.00 94.45 C \\\\nATOM 978 CD1 TYR A 128 -17.417 -7.286 19.612 1.00 94.45 C \\\\nATOM 979 CD2 TYR A 128 -15.647 -5.676 20.023 1.00 94.45 C \\\\nATOM 980 CE1 TYR A 128 -16.688 -8.263 20.326 1.00 94.45 C \\\\nATOM 981 CE2 TYR A 128 -14.923 -6.631 20.751 1.00 94.45 C \\\\nATOM 982 OH TYR A 128 -14.702 -8.853 21.570 1.00 94.45 O \\\\nATOM 983 CZ TYR A 128 -15.439 -7.932 20.894 1.00 94.45 C \\\\nATOM 984 N CYS A 129 -18.287 -3.513 15.647 1.00 94.84 N \\\\nATOM 985 CA CYS A 129 -19.075 -2.754 14.671 1.00 94.84 C \\\\nATOM 986 C CYS A 129 -19.608 -3.661 13.555 1.00 94.84 C \\\\nATOM 987 CB CYS A 129 -18.240 -1.615 14.078 1.00 94.84 C \\\\nATOM 988 O CYS A 129 -20.777 -3.539 13.185 1.00 94.84 O \\\\nATOM 989 SG CYS A 129 -17.923 -0.349 15.334 1.00 94.84 S \\\\nATOM 990 N ARG A 130 -18.794 -4.612 13.071 1.00 93.45 N \\\\nATOM 991 CA ARG A 130 -19.218 -5.591 12.064 1.00 93.45 C \\\\nATOM 992 C ARG A 130 -20.382 -6.446 12.561 1.00 93.45 C \\\\nATOM 993 CB ARG A 130 -18.024 -6.446 11.593 1.00 93.45 C \\\\nATOM 994 O ARG A 130 -21.346 -6.669 11.841 1.00 93.45 O \\\\nATOM 995 CG ARG A 130 -18.402 -7.345 10.401 1.00 93.45 C \\\\nATOM 996 CD ARG A 130 -17.297 -8.325 9.987 1.00 93.45 C \\\\nATOM 997 NE ARG A 130 -16.140 -7.643 9.388 1.00 93.45 N \\\\nATOM 998 NH1 ARG A 130 -14.894 -9.481 8.823 1.00 93.45 N \\\\nATOM 999 NH2 ARG A 130 -14.164 -7.456 8.280 1.00 93.45 N \\\\nATOM 1000 CZ ARG A 130 -15.073 -8.194 8.841 1.00 93.45 C \\\\nATOM 1001 N LEU A 131 -20.314 -6.886 13.817 1.00 93.42 N \\\\nATOM 1002 CA LEU A 131 -21.314 -7.774 14.406 1.00 93.42 C \\\\nATOM 1003 C LEU A 131 -22.680 -7.088 14.596 1.00 93.42 C \\\\nATOM 1004 CB LEU A 131 -20.719 -8.351 15.707 1.00 93.42 C \\\\nATOM 1005 O LEU A 131 -23.709 -7.687 14.289 1.00 93.42 O \\\\nATOM 1006 CG LEU A 131 -21.370 -9.671 16.157 1.00 93.42 C \\\\nATOM 1007 CD1 LEU A 131 -20.361 -10.540 16.910 1.00 93.42 C \\\\nATOM 1008 CD2 LEU A 131 -22.557 -9.466 17.093 1.00 93.42 C \\\\nATOM 1009 N TRP A 132 -22.702 -5.844 15.089 1.00 95.06 N \\\\nATOM 1010 CA TRP A 132 -23.948 -5.172 15.499 1.00 95.06 C \\\\nATOM 1011 C TRP A 132 -24.456 -4.081 14.555 1.00 95.06 C \\\\nATOM 1012 CB TRP A 132 -23.787 -4.636 16.926 1.00 95.06 C \\\\nATOM 1013 O TRP A 132 -25.597 -3.646 14.709 1.00 95.06 O \\\\nATOM 1014 CG TRP A 132 -23.688 -5.707 17.963 1.00 95.06 C \\\\nATOM 1015 CD1 TRP A 132 -24.630 -6.650 18.186 1.00 95.06 C \\\\nATOM 1016 CD2 TRP A 132 -22.612 -5.982 18.908 1.00 95.06 C \\\\nATOM 1017 CE2 TRP A 132 -22.962 -7.158 19.640 1.00 95.06 C \\\\nATOM 1018 CE3 TRP A 132 -21.388 -5.357 19.239 1.00 95.06 C \\\\nATOM 1019 NE1 TRP A 132 -24.209 -7.512 19.174 1.00 95.06 N \\\\nATOM 1020 CH2 TRP A 132 -20.887 -7.109 20.860 1.00 95.06 C \\\\nATOM 1021 CZ2 TRP A 132 -22.104 -7.738 20.579 1.00 95.06 C \\\\nATOM 1022 CZ3 TRP A 132 -20.553 -5.900 20.234 1.00 95.06 C \\\\nATOM 1023 N ARG A 133 -23.656 -3.624 13.585 1.00 93.80 N \\\\nATOM 1024 CA ARG A 133 -24.057 -2.527 12.688 1.00 93.80 C \\\\nATOM 1025 C ARG A 133 -23.903 -2.858 11.214 1.00 93.80 C \\\\nATOM 1026 CB ARG A 133 -23.327 -1.232 13.054 1.00 93.80 C \\\\nATOM 1027 O ARG A 133 -24.900 -2.799 10.502 1.00 93.80 O \\\\nATOM 1028 CG ARG A 133 -23.740 -0.768 14.456 1.00 93.80 C \\\\nATOM 1029 CD ARG A 133 -23.208 0.630 14.740 1.00 93.80 C \\\\nATOM 1030 NE ARG A 133 -23.885 1.638 13.906 1.00 93.80 N \\\\nATOM 1031 NH1 ARG A 133 -22.534 3.330 14.523 1.00 93.80 N \\\\nATOM 1032 NH2 ARG A 133 -24.172 3.753 13.078 1.00 93.80 N \\\\nATOM 1033 CZ ARG A 133 -23.534 2.902 13.829 1.00 93.80 C \\\\nATOM 1034 N TRP A 134 -22.698 -3.219 10.781 1.00 92.86 N \\\\nATOM 1035 CA TRP A 134 -22.355 -3.332 9.359 1.00 92.86 C \\\\nATOM 1036 C TRP A 134 -21.638 -4.658 9.065 1.00 92.86 C \\\\nATOM 1037 CB TRP A 134 -21.502 -2.122 8.961 1.00 92.86 C \\\\nATOM 1038 O TRP A 134 -20.412 -4.713 9.159 1.00 92.86 O \\\\nATOM 1039 CG TRP A 134 -22.128 -0.786 9.203 1.00 92.86 C \\\\nATOM 1040 CD1 TRP A 134 -23.200 -0.283 8.552 1.00 92.86 C \\\\nATOM 1041 CD2 TRP A 134 -21.717 0.237 10.155 1.00 92.86 C \\\\nATOM 1042 CE2 TRP A 134 -22.578 1.364 10.001 1.00 92.86 C \\\\nATOM 1043 CE3 TRP A 134 -20.693 0.326 11.122 1.00 92.86 C \\\\nATOM 1044 NE1 TRP A 134 -23.466 0.992 9.014 1.00 92.86 N \\\\nATOM 1045 CH2 TRP A 134 -21.345 2.608 11.666 1.00 92.86 C \\\\nATOM 1046 CZ2 TRP A 134 -22.397 2.543 10.734 1.00 92.86 C \\\\nATOM 1047 CZ3 TRP A 134 -20.518 1.495 11.882 1.00 92.86 C \\\\nATOM 1048 N PRO A 135 -22.366 -5.742 8.736 1.00 90.70 N \\\\nATOM 1049 CA PRO A 135 -21.776 -7.058 8.453 1.00 90.70 C \\\\nATOM 1050 C PRO A 135 -20.717 -7.044 7.344 1.00 90.70 C \\\\nATOM 1051 CB PRO A 135 -22.955 -7.949 8.049 1.00 90.70 C \\\\nATOM 1052 O PRO A 135 -19.789 -7.847 7.363 1.00 90.70 O \\\\nATOM 1053 CG PRO A 135 -24.131 -7.309 8.777 1.00 90.70 C \\\\nATOM 1054 CD PRO A 135 -23.817 -5.820 8.695 1.00 90.70 C \\\\nATOM 1055 N ASP A 136 -20.846 -6.097 6.421 1.00 86.88 N \\\\nATOM 1056 CA ASP A 136 -19.995 -5.838 5.263 1.00 86.88 C \\\\nATOM 1057 C ASP A 136 -18.812 -4.895 5.560 1.00 86.88 C \\\\nATOM 1058 CB ASP A 136 -20.896 -5.265 4.158 1.00 86.88 C \\\\nATOM 1059 O ASP A 136 -18.151 -4.428 4.642 1.00 86.88 O \\\\nATOM 1060 CG ASP A 136 -21.458 -3.882 4.516 1.00 86.88 C \\\\nATOM 1061 OD1 ASP A 136 -21.929 -3.679 5.663 1.00 86.88 O \\\\nATOM 1062 OD2 ASP A 136 -21.416 -2.979 3.656 1.00 86.88 O \\\\nATOM 1063 N LEU A 137 -18.537 -4.569 6.825 1.00 87.97 N \\\\nATOM 1064 CA LEU A 137 -17.401 -3.726 7.204 1.00 87.97 C \\\\nATOM 1065 C LEU A 137 -16.083 -4.498 7.075 1.00 87.97 C \\\\nATOM 1066 CB LEU A 137 -17.626 -3.275 8.656 1.00 87.97 C \\\\nATOM 1067 O LEU A 137 -15.883 -5.449 7.826 1.00 87.97 O \\\\nATOM 1068 CG LEU A 137 -16.543 -2.322 9.169 1.00 87.97 C \\\\nATOM 1069 CD1 LEU A 137 -16.738 -0.932 8.577 1.00 87.97 C \\\\nATOM 1070 CD2 LEU A 137 -16.615 -2.224 10.690 1.00 87.97 C \\\\nATOM 1071 N HIS A 138 -15.128 -4.080 6.248 1.00 80.97 N \\\\nATOM 1072 CA HIS A 138 -13.871 -4.808 6.009 1.00 80.97 C \\\\nATOM 1073 C HIS A 138 -12.685 -4.237 6.790 1.00 80.97 C \\\\nATOM 1074 CB HIS A 138 -13.578 -4.858 4.507 1.00 80.97 C \\\\nATOM 1075 O HIS A 138 -11.864 -4.998 7.313 1.00 80.97 O \\\\nATOM 1076 CG HIS A 138 -14.632 -5.637 3.769 1.00 80.97 C \\\\nATOM 1077 CD2 HIS A 138 -14.644 -6.985 3.527 1.00 80.97 C \\\\nATOM 1078 ND1 HIS A 138 -15.826 -5.137 3.311 1.00 80.97 N \\\\nATOM 1079 CE1 HIS A 138 -16.550 -6.158 2.830 1.00 80.97 C \\\\nATOM 1080 NE2 HIS A 138 -15.882 -7.311 2.973 1.00 80.97 N \\\\nATOM 1081 N SER A 139 -12.614 -2.912 6.917 1.00 83.17 N \\\\nATOM 1082 CA SER A 139 -11.460 -2.200 7.465 1.00 83.17 C \\\\nATOM 1083 C SER A 139 -11.837 -1.201 8.559 1.00 83.17 C \\\\nATOM 1084 CB SER A 139 -10.727 -1.495 6.323 1.00 83.17 C \\\\nATOM 1085 O SER A 139 -12.946 -0.681 8.615 1.00 83.17 O \\\\nATOM 1086 OG SER A 139 -9.516 -0.929 6.795 1.00 83.17 O \\\\nATOM 1087 N HIS A 140 -10.874 -0.881 9.425 1.00 86.11 N \\\\nATOM 1088 CA HIS A 140 -11.016 0.216 10.386 1.00 86.11 C \\\\nATOM 1089 C HIS A 140 -11.071 1.593 9.723 1.00 86.11 C \\\\nATOM 1090 CB HIS A 140 -9.873 0.183 11.399 1.00 86.11 C \\\\nATOM 1091 O HIS A 140 -11.634 2.512 10.302 1.00 86.11 O \\\\nATOM 1092 CG HIS A 140 -8.528 0.596 10.861 1.00 86.11 C \\\\nATOM 1093 CD2 HIS A 140 -7.865 1.738 11.215 1.00 86.11 C \\\\nATOM 1094 ND1 HIS A 140 -7.736 -0.065 9.944 1.00 86.11 N \\\\nATOM 1095 CE1 HIS A 140 -6.614 0.656 9.776 1.00 86.11 C \\\\nATOM 1096 NE2 HIS A 140 -6.642 1.752 10.548 1.00 86.11 N \\\\nATOM 1097 N HIS A 141 -10.518 1.731 8.516 1.00 83.95 N \\\\nATOM 1098 CA HIS A 141 -10.558 2.982 7.763 1.00 83.95 C \\\\nATOM 1099 C HIS A 141 -11.983 3.357 7.319 1.00 83.95 C \\\\nATOM 1100 CB HIS A 141 -9.626 2.852 6.557 1.00 83.95 C \\\\nATOM 1101 O HIS A 141 -12.252 4.526 7.079 1.00 83.95 O \\\\nATOM 1102 CG HIS A 141 -8.176 2.638 6.875 1.00 83.95 C \\\\nATOM 1103 CD2 HIS A 141 -7.388 1.619 6.415 1.00 83.95 C \\\\nATOM 1104 ND1 HIS A 141 -7.370 3.480 7.600 1.00 83.95 N \\\\nATOM 1105 CE1 HIS A 141 -6.130 2.966 7.596 1.00 83.95 C \\\\nATOM 1106 NE2 HIS A 141 -6.101 1.811 6.913 1.00 83.95 N \\\\nATOM 1107 N GLU A 142 -12.907 2.391 7.256 1.00 89.04 N \\\\nATOM 1108 CA GLU A 142 -14.330 2.634 6.979 1.00 89.04 C \\\\nATOM 1109 C GLU A 142 -15.081 3.182 8.203 1.00 89.04 C \\\\nATOM 1110 CB GLU A 142 -14.996 1.327 6.533 1.00 89.04 C \\\\nATOM 1111 O GLU A 142 -16.275 3.461 8.114 1.00 89.04 O \\\\nATOM 1112 CG GLU A 142 -14.534 0.776 5.184 1.00 89.04 C \\\\nATOM 1113 CD GLU A 142 -15.197 -0.587 4.961 1.00 89.04 C \\\\nATOM 1114 OE1 GLU A 142 -14.500 -1.600 5.214 1.00 89.04 O \\\\nATOM 1115 OE2 GLU A 142 -16.417 -0.627 4.667 1.00 89.04 O \\\\nATOM 1116 N LEU A 143 -14.414 3.318 9.354 1.00 92.20 N \\\\nATOM 1117 CA LEU A 143 -14.996 3.828 10.589 1.00 92.20 C \\\\nATOM 1118 C LEU A 143 -14.329 5.133 11.019 1.00 92.20 C \\\\nATOM 1119 CB LEU A 143 -14.878 2.787 11.713 1.00 92.20 C \\\\nATOM 1120 O LEU A 143 -13.109 5.228 11.135 1.00 92.20 O \\\\nATOM 1121 CG LEU A 143 -15.634 1.470 11.494 1.00 92.20 C \\\\nATOM 1122 CD1 LEU A 143 -15.407 0.591 12.728 1.00 92.20 C \\\\nATOM 1123 CD2 LEU A 143 -17.138 1.678 11.311 1.00 92.20 C \\\\nATOM 1124 N LYS A 144 -15.152 6.111 11.389 1.00 92.19 N \\\\nATOM 1125 CA LYS A 144 -14.738 7.329 12.086 1.00 92.19 C \\\\nATOM 1126 C LYS A 144 -15.326 7.324 13.491 1.00 92.19 C \\\\nATOM 1127 CB LYS A 144 -15.184 8.540 11.257 1.00 92.19 C \\\\nATOM 1128 O LYS A 144 -16.518 7.089 13.653 1.00 92.19 O \\\\nATOM 1129 CG LYS A 144 -14.603 9.851 11.803 1.00 92.19 C \\\\nATOM 1130 CD LYS A 144 -15.084 11.048 10.975 1.00 92.19 C \\\\nATOM 1131 CE LYS A 144 -14.518 12.350 11.557 1.00 92.19 C \\\\nATOM 1132 NZ LYS A 144 -15.052 13.546 10.857 1.00 92.19 N \\\\nATOM 1133 N ALA A 145 -14.516 7.560 14.518 1.00 93.48 N \\\\nATOM 1134 CA ALA A 145 -15.049 7.713 15.868 1.00 93.48 C \\\\nATOM 1135 C ALA A 145 -15.831 9.030 16.001 1.00 93.48 C \\\\nATOM 1136 CB ALA A 145 -13.917 7.608 16.883 1.00 93.48 C \\\\nATOM 1137 O ALA A 145 -15.466 10.033 15.386 1.00 93.48 O \\\\nATOM 1138 N ILE A 146 -16.892 9.026 16.808 1.00 93.88 N \\\\nATOM 1139 CA ILE A 146 -17.597 10.257 17.182 1.00 93.88 C \\\\nATOM 1140 C ILE A 146 -16.704 11.122 18.078 1.00 93.88 C \\\\nATOM 1141 CB ILE A 146 -18.961 9.968 17.849 1.00 93.88 C \\\\nATOM 1142 O ILE A 146 -15.877 10.599 18.826 1.00 93.88 O \\\\nATOM 1143 CG1 ILE A 146 -18.805 9.282 19.226 1.00 93.88 C \\\\nATOM 1144 CG2 ILE A 146 -19.859 9.172 16.883 1.00 93.88 C \\\\nATOM 1145 CD1 ILE A 146 -20.121 9.053 19.971 1.00 93.88 C \\\\nATOM 1146 N GLU A 147 -16.913 12.435 18.052 1.00 91.33 N \\\\nATOM 1147 CA GLU A 147 -16.085 13.403 18.790 1.00 91.33 C \\\\nATOM 1148 C GLU A 147 -16.111 13.177 20.310 1.00 91.33 C \\\\nATOM 1149 CB GLU A 147 -16.553 14.823 18.439 1.00 91.33 C \\\\nATOM 1150 O GLU A 147 -15.098 13.340 20.983 1.00 91.33 O \\\\nATOM 1151 CG GLU A 147 -16.354 15.112 16.940 1.00 91.33 C \\\\nATOM 1152 CD GLU A 147 -16.770 16.525 16.513 1.00 91.33 C \\\\nATOM 1153 OE1 GLU A 147 -16.509 16.831 15.328 1.00 91.33 O \\\\nATOM 1154 OE2 GLU A 147 -17.365 17.248 17.340 1.00 91.33 O \\\\nATOM 1155 N ASN A 148 -17.234 12.684 20.840 1.00 91.34 N \\\\nATOM 1156 CA ASN A 148 -17.417 12.424 22.271 1.00 91.34 C \\\\nATOM 1157 C ASN A 148 -16.788 11.098 22.750 1.00 91.34 C \\\\nATOM 1158 CB ASN A 148 -18.923 12.499 22.595 1.00 91.34 C \\\\nATOM 1159 O ASN A 148 -16.949 10.719 23.912 1.00 91.34 O \\\\nATOM 1160 CG ASN A 148 -19.535 13.868 22.344 1.00 91.34 C \\\\nATOM 1161 ND2 ASN A 148 -20.838 13.988 22.425 1.00 91.34 N \\\\nATOM 1162 OD1 ASN A 148 -18.871 14.846 22.065 1.00 91.34 O \\\\nATOM 1163 N CYS A 149 -16.116 10.339 21.876 1.00 93.59 N \\\\nATOM 1164 CA CYS A 149 -15.512 9.064 22.252 1.00 93.59 C \\\\nATOM 1165 C CYS A 149 -14.118 9.261 22.868 1.00 93.59 C \\\\nATOM 1166 CB CYS A 149 -15.482 8.123 21.045 1.00 93.59 C \\\\nATOM 1167 O CYS A 149 -13.117 9.411 22.171 1.00 93.59 O \\\\nATOM 1168 SG CYS A 149 -15.018 6.462 21.626 1.00 93.59 S \\\\nATOM 1169 N GLU A 150 -14.029 9.163 24.194 1.00 93.72 N \\\\nATOM 1170 CA GLU A 150 -12.774 9.344 24.940 1.00 93.72 C \\\\nATOM 1171 C GLU A 150 -11.730 8.236 24.711 1.00 93.72 C \\\\nATOM 1172 CB GLU A 150 -13.086 9.387 26.438 1.00 93.72 C \\\\nATOM 1173 O GLU A 150 -10.553 8.426 25.023 1.00 93.72 O \\\\nATOM 1174 CG GLU A 150 -13.967 10.569 26.859 1.00 93.72 C \\\\nATOM 1175 CD GLU A 150 -14.248 10.552 28.369 1.00 93.72 C \\\\nATOM 1176 OE1 GLU A 150 -14.711 11.592 28.878 1.00 93.72 O \\\\nATOM 1177 OE2 GLU A 150 -14.031 9.488 29.003 1.00 93.72 O \\\\nATOM 1178 N TYR A 151 -12.142 7.075 24.195 1.00 93.47 N \\\\nATOM 1179 CA TYR A 151 -11.293 5.890 23.995 1.00 93.47 C \\\\nATOM 1180 C TYR A 151 -11.321 5.414 22.538 1.00 93.47 C \\\\nATOM 1181 CB TYR A 151 -11.669 4.785 24.992 1.00 93.47 C \\\\nATOM 1182 O TYR A 151 -11.233 4.219 22.254 1.00 93.47 O \\\\nATOM 1183 CG TYR A 151 -11.472 5.166 26.442 1.00 93.47 C \\\\nATOM 1184 CD1 TYR A 151 -10.273 4.836 27.103 1.00 93.47 C \\\\nATOM 1185 CD2 TYR A 151 -12.494 5.844 27.131 1.00 93.47 C \\\\nATOM 1186 CE1 TYR A 151 -10.105 5.180 28.459 1.00 93.47 C \\\\nATOM 1187 CE2 TYR A 151 -12.315 6.225 28.472 1.00 93.47 C \\\\nATOM 1188 OH TYR A 151 -10.938 6.273 30.427 1.00 93.47 O \\\\nATOM 1189 CZ TYR A 151 -11.120 5.884 29.140 1.00 93.47 C \\\\nATOM 1190 N ALA A 152 -11.501 6.342 21.600 1.00 91.45 N \\\\nATOM 1191 CA ALA A 152 -11.484 6.039 20.179 1.00 91.45 C \\\\nATOM 1192 C ALA A 152 -10.160 5.383 19.747 1.00 91.45 C \\\\nATOM 1193 CB ALA A 152 -11.749 7.336 19.422 1.00 91.45 C \\\\nATOM 1194 O ALA A 152 -9.087 5.708 20.256 1.00 91.45 O \\\\nATOM 1195 N PHE A 153 -10.225 4.463 18.780 1.00 88.26 N \\\\nATOM 1196 CA PHE A 153 -9.057 3.704 18.316 1.00 88.26 C \\\\nATOM 1197 C PHE A 153 -7.881 4.587 17.858 1.00 88.26 C \\\\nATOM 1198 CB PHE A 153 -9.508 2.782 17.176 1.00 88.26 C \\\\nATOM 1199 O PHE A 153 -6.724 4.286 18.149 1.00 88.26 O \\\\nATOM 1200 CG PHE A 153 -8.366 2.037 16.511 1.00 88.26 C \\\\nATOM 1201 CD1 PHE A 153 -7.961 2.377 15.205 1.00 88.26 C \\\\nATOM 1202 CD2 PHE A 153 -7.685 1.024 17.212 1.00 88.26 C \\\\nATOM 1203 CE1 PHE A 153 -6.883 1.703 14.605 1.00 88.26 C \\\\nATOM 1204 CE2 PHE A 153 -6.613 0.347 16.607 1.00 88.26 C \\\\nATOM 1205 CZ PHE A 153 -6.213 0.684 15.303 1.00 88.26 C \\\\nATOM 1206 N ASN A 154 -8.167 5.704 17.189 1.00 84.98 N \\\\nATOM 1207 CA ASN A 154 -7.164 6.657 16.710 1.00 84.98 C \\\\nATOM 1208 C ASN A 154 -6.425 7.402 17.838 1.00 84.98 C \\\\nATOM 1209 CB ASN A 154 -7.825 7.648 15.730 1.00 84.98 C \\\\nATOM 1210 O ASN A 154 -5.341 7.921 17.585 1.00 84.98 O \\\\nATOM 1211 CG ASN A 154 -8.927 8.482 16.366 1.00 84.98 C \\\\nATOM 1212 ND2 ASN A 154 -9.030 9.748 16.048 1.00 84.98 N \\\\nATOM 1213 OD1 ASN A 154 -9.725 7.990 17.145 1.00 84.98 O \\\\nATOM 1214 N LEU A 155 -6.959 7.425 19.067 1.00 87.90 N \\\\nATOM 1215 CA LEU A 155 -6.299 8.036 20.228 1.00 87.90 C \\\\nATOM 1216 C LEU A 155 -5.151 7.181 20.790 1.00 87.90 C \\\\nATOM 1217 CB LEU A 155 -7.331 8.347 21.331 1.00 87.90 C \\\\nATOM 1218 O LEU A 155 -4.417 7.667 21.644 1.00 87.90 O \\\\nATOM 1219 CG LEU A 155 -8.442 9.332 20.931 1.00 87.90 C \\\\nATOM 1220 CD1 LEU A 155 -9.445 9.459 22.078 1.00 87.90 C \\\\nATOM 1221 CD2 LEU A 155 -7.894 10.724 20.616 1.00 87.90 C \\\\nATOM 1222 N LYS A 156 -4.992 5.926 20.330 1.00 83.25 N \\\\nATOM 1223 CA LYS A 156 -3.895 5.009 20.710 1.00 83.25 C \\\\nATOM 1224 C LYS A 156 -3.679 4.876 22.230 1.00 83.25 C \\\\nATOM 1225 CB LYS A 156 -2.595 5.394 19.979 1.00 83.25 C \\\\nATOM 1226 O LYS A 156 -2.548 4.755 22.690 1.00 83.25 O \\\\nATOM 1227 CG LYS A 156 -2.698 5.336 18.450 1.00 83.25 C \\\\nATOM 1228 CD LYS A 156 -1.342 5.712 17.841 1.00 83.25 C \\\\nATOM 1229 CE LYS A 156 -1.398 5.654 16.312 1.00 83.25 C \\\\nATOM 1230 NZ LYS A 156 -0.087 6.019 15.718 1.00 83.25 N \\\\nATOM 1231 N LYS A 157 -4.767 4.903 23.003 1.00 86.70 N \\\\nATOM 1232 CA LYS A 157 -4.747 4.689 24.457 1.00 86.70 C \\\\nATOM 1233 C LYS A 157 -4.578 3.207 24.801 1.00 86.70 C \\\\nATOM 1234 CB LYS A 157 -6.028 5.266 25.084 1.00 86.70 C \\\\nATOM 1235 O LYS A 157 -4.794 2.338 23.958 1.00 86.70 O \\\\nATOM 1236 CG LYS A 157 -6.087 6.797 24.984 1.00 86.70 C \\\\nATOM 1237 CD LYS A 157 -7.306 7.338 25.742 1.00 86.70 C \\\\nATOM 1238 CE LYS A 157 -7.300 8.869 25.738 1.00 86.70 C \\\\nATOM 1239 NZ LYS A 157 -8.459 9.409 26.489 1.00 86.70 N \\\\nATOM 1240 N ASP A 158 -4.286 2.931 26.072 1.00 86.03 N \\\\nATOM 1241 CA ASP A 158 -4.174 1.565 26.599 1.00 86.03 C \\\\nATOM 1242 C ASP A 158 -5.472 0.765 26.502 1.00 86.03 C \\\\nATOM 1243 CB ASP A 158 -3.732 1.605 28.067 1.00 86.03 C \\\\nATOM 1244 O ASP A 158 -5.446 -0.463 26.437 1.00 86.03 O \\\\nATOM 1245 CG ASP A 158 -2.309 2.127 28.218 1.00 86.03 C \\\\nATOM 1246 OD1 ASP A 158 -1.483 1.767 27.348 1.00 86.03 O \\\\nATOM 1247 OD2 ASP A 158 -2.084 2.884 29.182 1.00 86.03 O \\\\nATOM 1248 N GLU A 159 -6.611 1.447 26.423 1.00 90.02 N \\\\nATOM 1249 CA GLU A 159 -7.905 0.844 26.152 1.00 90.02 C \\\\nATOM 1250 C GLU A 159 -8.516 1.379 24.857 1.00 90.02 C \\\\nATOM 1251 CB GLU A 159 -8.876 1.060 27.310 1.00 90.02 C \\\\nATOM 1252 O GLU A 159 -8.314 2.531 24.473 1.00 90.02 O \\\\nATOM 1253 CG GLU A 159 -8.393 0.591 28.687 1.00 90.02 C \\\\nATOM 1254 CD GLU A 159 -9.585 0.508 29.654 1.00 90.02 C \\\\nATOM 1255 OE1 GLU A 159 -9.783 -0.580 30.240 1.00 90.02 O \\\\nATOM 1256 OE2 GLU A 159 -10.397 1.463 29.700 1.00 90.02 O \\\\nATOM 1257 N VAL A 160 -9.326 0.542 24.209 1.00 92.39 N \\\\nATOM 1258 CA VAL A 160 -10.071 0.894 22.997 1.00 92.39 C \\\\nATOM 1259 C VAL A 160 -11.570 0.743 23.224 1.00 92.39 C \\\\nATOM 1260 CB VAL A 160 -9.555 0.097 21.785 1.00 92.39 C \\\\nATOM 1261 O VAL A 160 -12.034 -0.267 23.762 1.00 92.39 O \\\\nATOM 1262 CG1 VAL A 160 -9.741 -1.423 21.908 1.00 92.39 C \\\\nATOM 1263 CG2 VAL A 160 -10.216 0.560 20.481 1.00 92.39 C \\\\nATOM 1264 N CYS A 161 -12.340 1.738 22.786 1.00 95.50 N \\\\nATOM 1265 CA CYS A 161 -13.791 1.693 22.797 1.00 95.50 C \\\\nATOM 1266 C CYS A 161 -14.298 0.686 21.760 1.00 95.50 C \\\\nATOM 1267 CB CYS A 161 -14.386 3.086 22.558 1.00 95.50 C \\\\nATOM 1268 O CYS A 161 -13.922 0.727 20.589 1.00 95.50 O \\\\nATOM 1269 SG CYS A 161 -16.167 3.003 22.908 1.00 95.50 S \\\\nATOM 1270 N VAL A 162 -15.186 -0.203 22.184 1.00 94.95 N \\\\nATOM 1271 CA VAL A 162 -15.862 -1.212 21.362 1.00 94.95 C \\\\nATOM 1272 C VAL A 162 -17.372 -0.992 21.289 1.00 94.95 C \\\\nATOM 1273 CB VAL A 162 -15.524 -2.631 21.842 1.00 94.95 C \\\\nATOM 1274 O VAL A 162 -18.089 -1.851 20.781 1.00 94.95 O \\\\nATOM 1275 CG1 VAL A 162 -14.031 -2.924 21.651 1.00 94.95 C \\\\nATOM 1276 CG2 VAL A 162 -15.898 -2.904 23.300 1.00 94.95 C \\\\nATOM 1277 N ASN A 163 -17.863 0.148 21.786 1.00 95.41 N \\\\nATOM 1278 CA ASN A 163 -19.251 0.553 21.605 1.00 95.41 C \\\\nATOM 1279 C ASN A 163 -19.493 0.835 20.110 1.00 95.41 C \\\\nATOM 1280 CB ASN A 163 -19.545 1.782 22.483 1.00 95.41 C \\\\nATOM 1281 O ASN A 163 -18.922 1.790 19.579 1.00 95.41 O \\\\nATOM 1282 CG ASN A 163 -20.991 2.243 22.403 1.00 95.41 C \\\\nATOM 1283 ND2 ASN A 163 -21.418 3.024 23.364 1.00 95.41 N \\\\nATOM 1284 OD1 ASN A 163 -21.735 1.892 21.496 1.00 95.41 O \\\\nATOM 1285 N PRO A 164 -20.333 0.052 19.411 1.00 94.93 N \\\\nATOM 1286 CA PRO A 164 -20.509 0.213 17.974 1.00 94.93 C \\\\nATOM 1287 C PRO A 164 -21.177 1.545 17.590 1.00 94.93 C \\\\nATOM 1288 CB PRO A 164 -21.316 -1.015 17.552 1.00 94.93 C \\\\nATOM 1289 O PRO A 164 -21.033 1.986 16.452 1.00 94.93 O \\\\nATOM 1290 CG PRO A 164 -22.135 -1.362 18.793 1.00 94.93 C \\\\nATOM 1291 CD PRO A 164 -21.163 -1.033 19.920 1.00 94.93 C \\\\nATOM 1292 N TYR A 165 -21.868 2.218 18.518 1.00 95.74 N \\\\nATOM 1293 CA TYR A 165 -22.497 3.531 18.306 1.00 95.74 C \\\\nATOM 1294 C TYR A 165 -21.555 4.711 18.578 1.00 95.74 C \\\\nATOM 1295 CB TYR A 165 -23.792 3.622 19.123 1.00 95.74 C \\\\nATOM 1296 O TYR A 165 -21.940 5.860 18.384 1.00 95.74 O \\\\nATOM 1297 CG TYR A 165 -24.828 2.636 18.631 1.00 95.74 C \\\\nATOM 1298 CD1 TYR A 165 -25.656 2.982 17.546 1.00 95.74 C \\\\nATOM 1299 CD2 TYR A 165 -24.897 1.347 19.187 1.00 95.74 C \\\\nATOM 1300 CE1 TYR A 165 -26.551 2.039 17.010 1.00 95.74 C \\\\nATOM 1301 CE2 TYR A 165 -25.770 0.394 18.630 1.00 95.74 C \\\\nATOM 1302 OH TYR A 165 -27.473 -0.173 17.044 1.00 95.74 O \\\\nATOM 1303 CZ TYR A 165 -26.611 0.741 17.555 1.00 95.74 C \\\\nATOM 1304 N HIS A 166 -20.311 4.438 18.983 1.00 96.55 N \\\\nATOM 1305 CA HIS A 166 -19.236 5.436 19.062 1.00 96.55 C \\\\nATOM 1306 C HIS A 166 -18.425 5.553 17.774 1.00 96.55 C \\\\nATOM 1307 CB HIS A 166 -18.339 5.141 20.265 1.00 96.55 C \\\\nATOM 1308 O HIS A 166 -17.483 6.337 17.705 1.00 96.55 O \\\\nATOM 1309 CG HIS A 166 -18.963 5.469 21.593 1.00 96.55 C \\\\nATOM 1310 CD2 HIS A 166 -20.246 5.881 21.816 1.00 96.55 C \\\\nATOM 1311 ND1 HIS A 166 -18.243 5.555 22.785 1.00 96.55 N \\\\nATOM 1312 CE1 HIS A 166 -19.104 6.056 23.681 1.00 96.55 C \\\\nATOM 1313 NE2 HIS A 166 -20.313 6.236 23.137 1.00 96.55 N \\\\nATOM 1314 N TYR A 167 -18.809 4.800 16.749 1.00 95.99 N \\\\nATOM 1315 CA TYR A 167 -18.234 4.870 15.418 1.00 95.99 C \\\\nATOM 1316 C TYR A 167 -19.323 5.244 14.415 1.00 95.99 C \\\\nATOM 1317 CB TYR A 167 -17.535 3.543 15.095 1.00 95.99 C \\\\nATOM 1318 O TYR A 167 -20.494 4.939 14.606 1.00 95.99 O \\\\nATOM 1319 CG TYR A 167 -16.391 3.227 16.045 1.00 95.99 C \\\\nATOM 1320 CD1 TYR A 167 -15.102 3.728 15.781 1.00 95.99 C \\\\nATOM 1321 CD2 TYR A 167 -16.626 2.488 17.222 1.00 95.99 C \\\\nATOM 1322 CE1 TYR A 167 -14.053 3.494 16.690 1.00 95.99 C \\\\nATOM 1323 CE2 TYR A 167 -15.583 2.263 18.142 1.00 95.99 C \\\\nATOM 1324 OH TYR A 167 -13.262 2.544 18.736 1.00 95.99 O \\\\nATOM 1325 CZ TYR A 167 -14.291 2.772 17.876 1.00 95.99 C \\\\nATOM 1326 N GLN A 168 -18.962 5.909 13.336 1.00 93.44 N \\\\nATOM 1327 CA GLN A 168 -19.802 6.190 12.182 1.00 93.44 C \\\\nATOM 1328 C GLN A 168 -19.122 5.567 10.971 1.00 93.44 C \\\\nATOM 1329 CB GLN A 168 -19.992 7.702 12.024 1.00 93.44 C \\\\nATOM 1330 O GLN A 168 -17.891 5.559 10.897 1.00 93.44 O \\\\nATOM 1331 CG GLN A 168 -20.874 8.284 13.141 1.00 93.44 C \\\\nATOM 1332 CD GLN A 168 -20.992 9.804 13.068 1.00 93.44 C \\\\nATOM 1333 NE2 GLN A 168 -21.814 10.413 13.894 1.00 93.44 N \\\\nATOM 1334 OE1 GLN A 168 -20.336 10.479 12.298 1.00 93.44 O \\\\nATOM 1335 N ARG A 169 -19.905 5.005 10.051 1.00 91.38 N \\\\nATOM 1336 CA ARG A 169 -19.352 4.515 8.793 1.00 91.38 C \\\\nATOM 1337 C ARG A 169 -18.992 5.723 7.940 1.00 91.38 C \\\\nATOM 1338 CB ARG A 169 -20.329 3.558 8.104 1.00 91.38 C \\\\nATOM 1339 O ARG A 169 -19.748 6.688 7.908 1.00 91.38 O \\\\nATOM 1340 CG ARG A 169 -19.688 2.835 6.915 1.00 91.38 C \\\\nATOM 1341 CD ARG A 169 -20.634 1.759 6.375 1.00 91.38 C \\\\nATOM 1342 NE ARG A 169 -19.942 0.894 5.407 1.00 91.38 N \\\\nATOM 1343 NH1 ARG A 169 -21.627 -0.625 5.046 1.00 91.38 N \\\\nATOM 1344 NH2 ARG A 169 -19.646 -0.939 4.109 1.00 91.38 N \\\\nATOM 1345 CZ ARG A 169 -20.411 -0.206 4.856 1.00 91.38 C \\\\nATOM 1346 N VAL A 170 -17.837 5.680 7.296 1.00 88.40 N \\\\nATOM 1347 CA VAL A 170 -17.450 6.695 6.318 1.00 88.40 C \\\\nATOM 1348 C VAL A 170 -18.362 6.528 5.104 1.00 88.40 C \\\\nATOM 1349 CB VAL A 170 -15.959 6.576 5.956 1.00 88.40 C \\\\nATOM 1350 O VAL A 170 -18.325 5.495 4.438 1.00 88.40 O \\\\nATOM 1351 CG1 VAL A 170 -15.564 7.639 4.927 1.00 88.40 C \\\\nATOM 1352 CG2 VAL A 170 -15.075 6.775 7.199 1.00 88.40 C \\\\nATOM 1353 N GLU A 171 -19.219 7.514 4.864 1.00 82.22 N \\\\nATOM 1354 CA GLU A 171 -20.124 7.540 3.715 1.00 82.22 C \\\\nATOM 1355 C GLU A 171 -19.408 8.133 2.499 1.00 82.22 C \\\\nATOM 1356 CB GLU A 171 -21.407 8.317 4.059 1.00 82.22 C \\\\nATOM 1357 O GLU A 171 -18.624 9.076 2.625 1.00 82.22 O \\\\nATOM 1358 CG GLU A 171 -22.244 7.575 5.118 1.00 82.22 C \\\\nATOM 1359 CD GLU A 171 -23.545 8.288 5.520 1.00 82.22 C \\\\nATOM 1360 OE1 GLU A 171 -24.246 7.719 6.392 1.00 82.22 O \\\\nATOM 1361 OE2 GLU A 171 -23.828 9.381 4.983 1.00 82.22 O \\\\nATOM 1362 N THR A 172 -19.669 7.580 1.313 1.00 80.03 N \\\\nATOM 1363 CA THR A 172 -19.195 8.172 0.059 1.00 80.03 C \\\\nATOM 1364 C THR A 172 -20.025 9.421 -0.233 1.00 80.03 C \\\\nATOM 1365 CB THR A 172 -19.256 7.179 -1.107 1.00 80.03 C \\\\nATOM 1366 O THR A 172 -21.246 9.310 -0.362 1.00 80.03 O \\\\nATOM 1367 CG2 THR A 172 -18.685 7.755 -2.404 1.00 80.03 C \\\\nATOM 1368 OG1 THR A 172 -18.475 6.045 -0.796 1.00 80.03 O \\\\nATOM 1369 N PRO A 173 -19.405 10.609 -0.330 1.00 80.47 N \\\\nATOM 1370 CA PRO A 173 -20.132 11.834 -0.616 1.00 80.47 C \\\\nATOM 1371 C PRO A 173 -20.764 11.762 -2.009 1.00 80.47 C \\\\nATOM 1372 CB PRO A 173 -19.098 12.954 -0.499 1.00 80.47 C \\\\nATOM 1373 O PRO A 173 -20.144 11.285 -2.960 1.00 80.47 O \\\\nATOM 1374 CG PRO A 173 -17.772 12.263 -0.826 1.00 80.47 C \\\\nATOM 1375 CD PRO A 173 -17.973 10.853 -0.292 1.00 80.47 C \\\\nATOM 1376 N VAL A 174 -21.991 12.272 -2.140 1.00 82.51 N \\\\nATOM 1377 CA VAL A 174 -22.652 12.398 -3.445 1.00 82.51 C \\\\nATOM 1378 C VAL A 174 -21.908 13.453 -4.264 1.00 82.51 C \\\\nATOM 1379 CB VAL A 174 -24.147 12.744 -3.305 1.00 82.51 C \\\\nATOM 1380 O VAL A 174 -21.784 14.602 -3.839 1.00 82.51 O \\\\nATOM 1381 CG1 VAL A 174 -24.830 12.822 -4.677 1.00 82.51 C \\\\nATOM 1382 CG2 VAL A 174 -24.885 11.685 -2.474 1.00 82.51 C \\\\nATOM 1383 N LEU A 175 -21.392 13.056 -5.426 1.00 85.88 N \\\\nATOM 1384 CA LEU A 175 -20.677 13.953 -6.333 1.00 85.88 C \\\\nATOM 1385 C LEU A 175 -21.683 14.739 -7.196 1.00 85.88 C \\\\nATOM 1386 CB LEU A 175 -19.685 13.147 -7.190 1.00 85.88 C \\\\nATOM 1387 O LEU A 175 -22.635 14.137 -7.702 1.00 85.88 O \\\\nATOM 1388 CG LEU A 175 -18.604 12.400 -6.386 1.00 85.88 C \\\\nATOM 1389 CD1 LEU A 175 -17.801 11.463 -7.283 1.00 85.88 C \\\\nATOM 1390 CD2 LEU A 175 -17.627 13.363 -5.708 1.00 85.88 C \\\\nATOM 1391 N PRO A 176 -21.506 16.062 -7.378 1.00 86.02 N \\\\nATOM 1392 CA PRO A 176 -22.392 16.857 -8.224 1.00 86.02 C \\\\nATOM 1393 C PRO A 176 -22.263 16.431 -9.698 1.00 86.02 C \\\\nATOM 1394 CB PRO A 176 -21.967 18.312 -8.009 1.00 86.02 C \\\\nATOM 1395 O PRO A 176 -21.165 16.064 -10.123 1.00 86.02 O \\\\nATOM 1396 CG PRO A 176 -20.483 18.195 -7.657 1.00 86.02 C \\\\nATOM 1397 CD PRO A 176 -20.411 16.882 -6.878 1.00 86.02 C \\\\nATOM 1398 N PRO A 177 -23.344 16.482 -10.499 1.00 87.29 N \\\\nATOM 1399 CA PRO A 177 -23.257 16.213 -11.931 1.00 87.29 C \\\\nATOM 1400 C PRO A 177 -22.373 17.251 -12.631 1.00 87.29 C \\\\nATOM 1401 CB PRO A 177 -24.697 16.255 -12.451 1.00 87.29 C \\\\nATOM 1402 O PRO A 177 -22.425 18.440 -12.314 1.00 87.29 O \\\\nATOM 1403 CG PRO A 177 -25.403 17.184 -11.463 1.00 87.29 C \\\\nATOM 1404 CD PRO A 177 -24.688 16.909 -10.139 1.00 87.29 C \\\\nATOM 1405 N VAL A 178 -21.600 16.805 -13.619 1.00 87.57 N \\\\nATOM 1406 CA VAL A 178 -20.834 17.696 -14.500 1.00 87.57 C \\\\nATOM 1407 C VAL A 178 -21.767 18.192 -15.599 1.00 87.57 C \\\\nATOM 1408 CB VAL A 178 -19.596 16.981 -15.070 1.00 87.57 C \\\\nATOM 1409 O VAL A 178 -22.409 17.384 -16.266 1.00 87.57 O \\\\nATOM 1410 CG1 VAL A 178 -18.864 17.835 -16.108 1.00 87.57 C \\\\nATOM 1411 CG2 VAL A 178 -18.600 16.666 -13.950 1.00 87.57 C \\\\nATOM 1412 N LEU A 179 -21.873 19.509 -15.769 1.00 87.79 N \\\\nATOM 1413 CA LEU A 179 -22.702 20.119 -16.808 1.00 87.79 C \\\\nATOM 1414 C LEU A 179 -21.874 20.288 -18.081 1.00 87.79 C \\\\nATOM 1415 CB LEU A 179 -23.254 21.470 -16.317 1.00 87.79 C \\\\nATOM 1416 O LEU A 179 -20.872 20.998 -18.060 1.00 87.79 O \\\\nATOM 1417 CG LEU A 179 -24.097 21.415 -15.032 1.00 87.79 C \\\\nATOM 1418 CD1 LEU A 179 -24.620 22.811 -14.697 1.00 87.79 C \\\\nATOM 1419 CD2 LEU A 179 -25.295 20.471 -15.156 1.00 87.79 C \\\\nATOM 1420 N VAL A 180 -22.289 19.647 -19.172 1.00 84.28 N \\\\nATOM 1421 CA VAL A 180 -21.601 19.720 -20.466 1.00 84.28 C \\\\nATOM 1422 C VAL A 180 -22.396 20.613 -21.422 1.00 84.28 C \\\\nATOM 1423 CB VAL A 180 -21.359 18.323 -21.065 1.00 84.28 C \\\\nATOM 1424 O VAL A 180 -23.571 20.321 -21.665 1.00 84.28 O \\\\nATOM 1425 CG1 VAL A 180 -20.531 18.447 -22.348 1.00 84.28 C \\\\nATOM 1426 CG2 VAL A 180 -20.586 17.436 -20.078 1.00 84.28 C \\\\nATOM 1427 N PRO A 181 -21.807 21.693 -21.967 1.00 78.12 N \\\\nATOM 1428 CA PRO A 181 -22.442 22.482 -23.017 1.00 78.12 C \\\\nATOM 1429 C PRO A 181 -22.627 21.643 -24.281 1.00 78.12 C \\\\nATOM 1430 CB PRO A 181 -21.519 23.687 -23.260 1.00 78.12 C \\\\nATOM 1431 O PRO A 181 -21.658 21.102 -24.813 1.00 78.12 O \\\\nATOM 1432 CG PRO A 181 -20.643 23.753 -22.010 1.00 78.12 C \\\\nATOM 1433 CD PRO A 181 -20.538 22.293 -21.584 1.00 78.12 C \\\\nATOM 1434 N ARG A 182 -23.855 21.550 -24.801 1.00 67.49 N \\\\nATOM 1435 CA ARG A 182 -24.062 21.007 -26.146 1.00 67.49 C \\\\nATOM 1436 C ARG A 182 -23.515 21.998 -27.170 1.00 67.49 C \\\\nATOM 1437 CB ARG A 182 -25.542 20.692 -26.386 1.00 67.49 C \\\\nATOM 1438 O ARG A 182 -23.953 23.146 -27.230 1.00 67.49 O \\\\nATOM 1439 CG ARG A 182 -25.978 19.452 -25.594 1.00 67.49 C \\\\nATOM 1440 CD ARG A 182 -27.438 19.144 -25.917 1.00 67.49 C \\\\nATOM 1441 NE ARG A 182 -27.885 17.885 -25.302 1.00 67.49 N \\\\nATOM 1442 NH1 ARG A 182 -30.126 18.198 -25.717 1.00 67.49 N \\\\nATOM 1443 NH2 ARG A 182 -29.440 16.332 -24.732 1.00 67.49 N \\\\nATOM 1444 CZ ARG A 182 -29.139 17.478 -25.265 1.00 67.49 C \\\\nATOM 1445 N HIS A 183 -22.548 21.562 -27.974 1.00 57.15 N \\\\nATOM 1446 CA HIS A 183 -22.051 22.350 -29.097 1.00 57.15 C \\\\nATOM 1447 C HIS A 183 -23.143 22.490 -30.162 1.00 57.15 C \\\\nATOM 1448 CB HIS A 183 -20.776 21.713 -29.680 1.00 57.15 C \\\\nATOM 1449 O HIS A 183 -23.293 21.614 -31.012 1.00 57.15 O \\\\nATOM 1450 CG HIS A 183 -19.515 22.141 -28.978 1.00 57.15 C \\\\nATOM 1451 CD2 HIS A 183 -18.673 21.359 -28.233 1.00 57.15 C \\\\nATOM 1452 ND1 HIS A 183 -18.973 23.407 -29.012 1.00 57.15 N \\\\nATOM 1453 CE1 HIS A 183 -17.836 23.388 -28.298 1.00 57.15 C \\\\nATOM 1454 NE2 HIS A 183 -17.608 22.162 -27.810 1.00 57.15 N \\\\nATOM 1455 N THR A 184 -23.876 23.605 -30.134 1.00 46.80 N \\\\nATOM 1456 CA THR A 184 -24.677 24.042 -31.286 1.00 46.80 C \\\\nATOM 1457 C THR A 184 -23.954 25.106 -32.118 1.00 46.80 C \\\\nATOM 1458 CB THR A 184 -26.113 24.462 -30.917 1.00 46.80 C \\\\nATOM 1459 O THR A 184 -24.179 25.140 -33.319 1.00 46.80 O \\\\nATOM 1460 CG2 THR A 184 -27.094 24.160 -32.053 1.00 46.80 C \\\\nATOM 1461 OG1 THR A 184 -26.596 23.744 -29.802 1.00 46.80 O \\\\nATOM 1462 N GLU A 185 -23.029 25.915 -31.574 1.00 42.59 N \\\\nATOM 1463 CA GLU A 185 -22.300 26.939 -32.355 1.00 42.59 C \\\\nATOM 1464 C GLU A 185 -20.865 27.188 -31.829 1.00 42.59 C \\\\nATOM 1465 CB GLU A 185 -23.118 28.248 -32.437 1.00 42.59 C \\\\nATOM 1466 O GLU A 185 -20.599 27.141 -30.628 1.00 42.59 O \\\\nATOM 1467 CG GLU A 185 -24.438 28.065 -33.220 1.00 42.59 C \\\\nATOM 1468 CD GLU A 185 -25.260 29.335 -33.440 1.00 42.59 C \\\\nATOM 1469 OE1 GLU A 185 -26.206 29.262 -34.258 1.00 42.59 O \\\\nATOM 1470 OE2 GLU A 185 -24.976 30.351 -32.769 1.00 42.59 O \\\\nATOM 1471 N ILE A 186 -19.920 27.403 -32.751 1.00 43.70 N \\\\nATOM 1472 CA ILE A 186 -18.473 27.564 -32.524 1.00 43.70 C \\\\nATOM 1473 C ILE A 186 -18.190 28.959 -31.940 1.00 43.70 C \\\\nATOM 1474 CB ILE A 186 -17.731 27.351 -33.876 1.00 43.70 C \\\\nATOM 1475 O ILE A 186 -18.321 29.960 -32.645 1.00 43.70 O \\\\nATOM 1476 CG1 ILE A 186 -17.917 25.903 -34.397 1.00 43.70 C \\\\nATOM 1477 CG2 ILE A 186 -16.227 27.681 -33.786 1.00 43.70 C \\\\nATOM 1478 CD1 ILE A 186 -17.621 25.743 -35.895 1.00 43.70 C \\\\nATOM 1479 N LEU A 187 -17.743 29.045 -30.682 1.00 41.65 N \\\\nATOM 1480 CA LEU A 187 -17.145 30.279 -30.164 1.00 41.65 C \\\\nATOM 1481 C LEU A 187 -15.734 30.433 -30.738 1.00 41.65 C \\\\nATOM 1482 CB LEU A 187 -17.170 30.334 -28.626 1.00 41.65 C \\\\nATOM 1483 O LEU A 187 -14.805 29.707 -30.389 1.00 41.65 O \\\\nATOM 1484 CG LEU A 187 -18.565 30.585 -28.022 1.00 41.65 C \\\\nATOM 1485 CD1 LEU A 187 -18.455 30.600 -26.497 1.00 41.65 C \\\\nATOM 1486 CD2 LEU A 187 -19.178 31.921 -28.456 1.00 41.65 C \\\\nATOM 1487 N THR A 188 -15.608 31.387 -31.655 1.00 39.88 N \\\\nATOM 1488 CA THR A 188 -14.369 31.743 -32.347 1.00 39.88 C \\\\nATOM 1489 C THR A 188 -13.667 32.847 -31.557 1.00 39.88 C \\\\nATOM 1490 CB THR A 188 -14.652 32.176 -33.805 1.00 39.88 C \\\\nATOM 1491 O THR A 188 -13.729 33.993 -31.963 1.00 39.88 O \\\\nATOM 1492 CG2 THR A 188 -13.409 32.051 -34.686 1.00 39.88 C \\\\nATOM 1493 OG1 THR A 188 -15.632 31.356 -34.407 1.00 39.88 O \\\\nATOM 1494 N GLU A 189 -13.096 32.520 -30.393 1.00 39.17 N \\\\nATOM 1495 CA GLU A 189 -12.008 33.261 -29.717 1.00 39.17 C \\\\nATOM 1496 C GLU A 189 -11.721 32.594 -28.357 1.00 39.17 C \\\\nATOM 1497 CB GLU A 189 -12.299 34.776 -29.537 1.00 39.17 C \\\\nATOM 1498 O GLU A 189 -12.476 32.743 -27.398 1.00 39.17 O \\\\nATOM 1499 CG GLU A 189 -11.503 35.615 -30.564 1.00 39.17 C \\\\nATOM 1500 CD GLU A 189 -11.864 37.112 -30.592 1.00 39.17 C \\\\nATOM 1501 OE1 GLU A 189 -11.347 37.804 -31.501 1.00 39.17 O \\\\nATOM 1502 OE2 GLU A 189 -12.600 37.578 -29.692 1.00 39.17 O \\\\nATOM 1503 N LEU A 190 -10.632 31.819 -28.274 1.00 46.02 N \\\\nATOM 1504 CA LEU A 190 -10.084 31.291 -27.019 1.00 46.02 C \\\\nATOM 1505 C LEU A 190 -8.787 32.052 -26.685 1.00 46.02 C \\\\nATOM 1506 CB LEU A 190 -9.839 29.770 -27.126 1.00 46.02 C \\\\nATOM 1507 O LEU A 190 -7.996 32.310 -27.598 1.00 46.02 O \\\\nATOM 1508 CG LEU A 190 -11.069 28.909 -26.773 1.00 46.02 C \\\\nATOM 1509 CD1 LEU A 190 -10.925 27.510 -27.372 1.00 46.02 C \\\\nATOM 1510 CD2 LEU A 190 -11.236 28.751 -25.258 1.00 46.02 C \\\\nATOM 1511 N PRO A 191 -8.544 32.405 -25.407 1.00 44.40 N \\\\nATOM 1512 CA PRO A 191 -7.281 32.997 -24.973 1.00 44.40 C \\\\nATOM 1513 C PRO A 191 -6.117 32.019 -25.213 1.00 44.40 C \\\\nATOM 1514 CB PRO A 191 -7.478 33.357 -23.496 1.00 44.40 C \\\\nATOM 1515 O PRO A 191 -6.349 30.810 -25.301 1.00 44.40 O \\\\nATOM 1516 CG PRO A 191 -8.582 32.417 -23.018 1.00 44.40 C \\\\nATOM 1517 CD PRO A 191 -9.399 32.116 -24.270 1.00 44.40 C \\\\nATOM 1518 N PRO A 192 -4.872 32.515 -25.343 1.00 44.87 N \\\\nATOM 1519 CA PRO A 192 -3.722 31.678 -25.668 1.00 44.87 C \\\\nATOM 1520 C PRO A 192 -3.588 30.547 -24.642 1.00 44.87 C \\\\nATOM 1521 CB PRO A 192 -2.510 32.619 -25.694 1.00 44.87 C \\\\nATOM 1522 O PRO A 192 -3.456 30.796 -23.446 1.00 44.87 O \\\\nATOM 1523 CG PRO A 192 -2.947 33.804 -24.832 1.00 44.87 C \\\\nATOM 1524 CD PRO A 192 -4.452 33.878 -25.071 1.00 44.87 C \\\\nATOM 1525 N LEU A 193 -3.669 29.307 -25.127 1.00 47.96 N \\\\nATOM 1526 CA LEU A 193 -3.348 28.114 -24.354 1.00 47.96 C \\\\nATOM 1527 C LEU A 193 -1.859 28.168 -24.002 1.00 47.96 C \\\\nATOM 1528 CB LEU A 193 -3.669 26.855 -25.189 1.00 47.96 C \\\\nATOM 1529 O LEU A 193 -1.025 28.289 -24.900 1.00 47.96 O \\\\nATOM 1530 CG LEU A 193 -5.169 26.516 -25.287 1.00 47.96 C \\\\nATOM 1531 CD1 LEU A 193 -5.420 25.532 -26.432 1.00 47.96 C \\\\nATOM 1532 CD2 LEU A 193 -5.678 25.874 -23.994 1.00 47.96 C \\\\nATOM 1533 N ASP A 194 -1.534 28.058 -22.714 1.00 43.48 N \\\\nATOM 1534 CA ASP A 194 -0.163 27.779 -22.297 1.00 43.48 C \\\\nATOM 1535 C ASP A 194 0.288 26.455 -22.931 1.00 43.48 C \\\\nATOM 1536 CB ASP A 194 -0.029 27.747 -20.764 1.00 43.48 C \\\\nATOM 1537 O ASP A 194 -0.447 25.463 -22.966 1.00 43.48 O \\\\nATOM 1538 CG ASP A 194 0.055 29.139 -20.120 1.00 43.48 C \\\\nATOM 1539 OD1 ASP A 194 0.655 30.045 -20.741 1.00 43.48 O \\\\nATOM 1540 OD2 ASP A 194 -0.427 29.269 -18.971 1.00 43.48 O \\\\nATOM 1541 N ASP A 195 1.502 26.463 -23.471 1.00 40.98 N \\\\nATOM 1542 CA ASP A 195 2.109 25.353 -24.193 1.00 40.98 C \\\\nATOM 1543 C ASP A 195 2.381 24.181 -23.226 1.00 40.98 C \\\\nATOM 1544 CB ASP A 195 3.357 25.896 -24.920 1.00 40.98 C \\\\nATOM 1545 O ASP A 195 3.425 24.073 -22.582 1.00 40.98 O \\\\nATOM 1546 CG ASP A 195 3.821 25.038 -26.099 1.00 40.98 C \\\\nATOM 1547 OD1 ASP A 195 3.338 23.887 -26.222 1.00 40.98 O \\\\nATOM 1548 OD2 ASP A 195 4.683 25.520 -26.864 1.00 40.98 O \\\\nATOM 1549 N TYR A 196 1.401 23.287 -23.074 1.00 45.99 N \\\\nATOM 1550 CA TYR A 196 1.498 22.073 -22.256 1.00 45.99 C \\\\nATOM 1551 C TYR A 196 2.280 20.949 -22.954 1.00 45.99 C \\\\nATOM 1552 CB TYR A 196 0.104 21.626 -21.782 1.00 45.99 C \\\\nATOM 1553 O TYR A 196 2.133 19.776 -22.601 1.00 45.99 O \\\\nATOM 1554 CG TYR A 196 -0.449 22.425 -20.621 1.00 45.99 C \\\\nATOM 1555 CD1 TYR A 196 0.004 22.188 -19.305 1.00 45.99 C \\\\nATOM 1556 CD2 TYR A 196 -1.435 23.397 -20.858 1.00 45.99 C \\\\nATOM 1557 CE1 TYR A 196 -0.532 22.927 -18.231 1.00 45.99 C \\\\nATOM 1558 CE2 TYR A 196 -1.974 24.134 -19.790 1.00 45.99 C \\\\nATOM 1559 OH TYR A 196 -2.055 24.617 -17.450 1.00 45.99 O \\\\nATOM 1560 CZ TYR A 196 -1.526 23.902 -18.477 1.00 45.99 C \\\\nATOM 1561 N THR A 197 3.168 21.259 -23.899 1.00 44.07 N \\\\nATOM 1562 CA THR A 197 4.138 20.294 -24.449 1.00 44.07 C \\\\nATOM 1563 C THR A 197 5.068 19.704 -23.373 1.00 44.07 C \\\\nATOM 1564 CB THR A 197 4.937 20.916 -25.605 1.00 44.07 C \\\\nATOM 1565 O THR A 197 5.636 18.633 -23.572 1.00 44.07 O \\\\nATOM 1566 CG2 THR A 197 4.119 20.933 -26.895 1.00 44.07 C \\\\nATOM 1567 OG1 THR A 197 5.316 22.233 -25.300 1.00 44.07 O \\\\nATOM 1568 N HIS A 198 5.111 20.292 -22.171 1.00 42.09 N \\\\nATOM 1569 CA HIS A 198 5.744 19.726 -20.969 1.00 42.09 C \\\\nATOM 1570 C HIS A 198 4.830 18.831 -20.098 1.00 42.09 C \\\\nATOM 1571 CB HIS A 198 6.354 20.877 -20.161 1.00 42.09 C \\\\nATOM 1572 O HIS A 198 5.241 18.362 -19.037 1.00 42.09 O \\\\nATOM 1573 CG HIS A 198 7.428 21.607 -20.924 1.00 42.09 C \\\\nATOM 1574 CD2 HIS A 198 7.425 22.924 -21.302 1.00 42.09 C \\\\nATOM 1575 ND1 HIS A 198 8.589 21.047 -21.409 1.00 42.09 N \\\\nATOM 1576 CE1 HIS A 198 9.273 22.005 -22.054 1.00 42.09 C \\\\nATOM 1577 NE2 HIS A 198 8.615 23.170 -21.994 1.00 42.09 N \\\\nATOM 1578 N SER A 199 3.585 18.569 -20.513 1.00 43.75 N \\\\nATOM 1579 CA SER A 199 2.611 17.784 -19.731 1.00 43.75 C \\\\nATOM 1580 C SER A 199 2.780 16.269 -19.848 1.00 43.75 C \\\\nATOM 1581 CB SER A 199 1.176 18.147 -20.110 1.00 43.75 C \\\\nATOM 1582 O SER A 199 2.189 15.538 -19.049 1.00 43.75 O \\\\nATOM 1583 OG SER A 199 0.904 17.723 -21.433 1.00 43.75 O \\\\nATOM 1584 N ILE A 200 3.559 15.781 -20.821 1.00 42.94 N \\\\nATOM 1585 CA ILE A 200 4.083 14.414 -20.812 1.00 42.94 C \\\\nATOM 1586 C ILE A 200 5.367 14.491 -20.005 1.00 42.94 C \\\\nATOM 1587 CB ILE A 200 4.378 13.862 -22.226 1.00 42.94 C \\\\nATOM 1588 O ILE A 200 6.360 15.025 -20.501 1.00 42.94 O \\\\nATOM 1589 CG1 ILE A 200 3.113 13.892 -23.105 1.00 42.94 C \\\\nATOM 1590 CG2 ILE A 200 4.921 12.419 -22.113 1.00 42.94 C \\\\nATOM 1591 CD1 ILE A 200 3.385 13.574 -24.580 1.00 42.94 C \\\\nATOM 1592 N PRO A 201 5.411 13.973 -18.773 1.00 48.89 N \\\\nATOM 1593 CA PRO A 201 6.698 13.882 -18.145 1.00 48.89 C \\\\nATOM 1594 C PRO A 201 7.513 12.838 -18.892 1.00 48.89 C \\\\nATOM 1595 CB PRO A 201 6.435 13.536 -16.703 1.00 48.89 C \\\\nATOM 1596 O PRO A 201 7.066 11.701 -19.058 1.00 48.89 O \\\\nATOM 1597 CG PRO A 201 4.922 13.301 -16.558 1.00 48.89 C \\\\nATOM 1598 CD PRO A 201 4.381 13.323 -17.983 1.00 48.89 C \\\\nATOM 1599 N GLU A 202 8.725 13.207 -19.300 1.00 54.78 N \\\\nATOM 1600 CA GLU A 202 9.679 12.321 -19.981 1.00 54.78 C \\\\nATOM 1601 C GLU A 202 9.876 10.989 -19.236 1.00 54.78 C \\\\nATOM 1602 CB GLU A 202 11.032 13.036 -20.092 1.00 54.78 C \\\\nATOM 1603 O GLU A 202 10.212 9.968 -19.833 1.00 54.78 O \\\\nATOM 1604 CG GLU A 202 11.007 14.228 -21.061 1.00 54.78 C \\\\nATOM 1605 CD GLU A 202 12.381 14.908 -21.171 1.00 54.78 C \\\\nATOM 1606 OE1 GLU A 202 12.648 15.502 -22.237 1.00 54.78 O \\\\nATOM 1607 OE2 GLU A 202 13.154 14.818 -20.188 1.00 54.78 O \\\\nATOM 1608 N ASN A 203 9.570 10.956 -17.934 1.00 64.59 N \\\\nATOM 1609 CA ASN A 203 9.573 9.748 -17.121 1.00 64.59 C \\\\nATOM 1610 C ASN A 203 8.459 8.712 -17.415 1.00 64.59 C \\\\nATOM 1611 CB ASN A 203 9.696 10.114 -15.636 1.00 64.59 C \\\\nATOM 1612 O ASN A 203 8.453 7.652 -16.776 1.00 64.59 O \\\\nATOM 1613 CG ASN A 203 8.514 10.710 -14.914 1.00 64.59 C \\\\nATOM 1614 ND2 ASN A 203 8.751 11.229 -13.733 1.00 64.59 N \\\\nATOM 1615 OD1 ASN A 203 7.370 10.626 -15.308 1.00 64.59 O \\\\nATOM 1616 N THR A 204 7.555 8.980 -18.366 1.00 56.41 N \\\\nATOM 1617 CA THR A 204 6.367 8.156 -18.675 1.00 56.41 C \\\\nATOM 1618 C THR A 204 6.367 7.475 -20.049 1.00 56.41 C \\\\nATOM 1619 CB THR A 204 5.059 8.951 -18.512 1.00 56.41 C \\\\nATOM 1620 O THR A 204 5.433 6.726 -20.332 1.00 56.41 O \\\\nATOM 1621 CG2 THR A 204 4.880 9.530 -17.113 1.00 56.41 C \\\\nATOM 1622 OG1 THR A 204 4.971 10.026 -19.414 1.00 56.41 O \\\\nATOM 1623 N ASN A 205 7.384 7.676 -20.897 1.00 49.30 N \\\\nATOM 1624 CA ASN A 205 7.339 7.163 -22.271 1.00 49.30 C \\\\nATOM 1625 C ASN A 205 7.411 5.624 -22.351 1.00 49.30 C \\\\nATOM 1626 CB ASN A 205 8.401 7.859 -23.157 1.00 49.30 C \\\\nATOM 1627 O ASN A 205 8.383 4.995 -21.919 1.00 49.30 O \\\\nATOM 1628 CG ASN A 205 7.823 8.911 -24.097 1.00 49.30 C \\\\nATOM 1629 ND2 ASN A 205 8.634 9.491 -24.948 1.00 49.30 N \\\\nATOM 1630 OD1 ASN A 205 6.647 9.226 -24.088 1.00 49.30 O \\\\nATOM 1631 N PHE A 206 6.385 5.039 -22.974 1.00 41.13 N \\\\nATOM 1632 CA PHE A 206 6.423 3.713 -23.590 1.00 41.13 C \\\\nATOM 1633 C PHE A 206 6.857 3.858 -25.057 1.00 41.13 C \\\\nATOM 1634 CB PHE A 206 5.035 3.059 -23.535 1.00 41.13 C \\\\nATOM 1635 O PHE A 206 6.550 4.880 -25.673 1.00 41.13 O \\\\nATOM 1636 CG PHE A 206 4.514 2.747 -22.147 1.00 41.13 C \\\\nATOM 1637 CD1 PHE A 206 4.761 1.489 -21.561 1.00 41.13 C \\\\nATOM 1638 CD2 PHE A 206 3.716 3.689 -21.474 1.00 41.13 C \\\\nATOM 1639 CE1 PHE A 206 4.166 1.158 -20.330 1.00 41.13 C \\\\nATOM 1640 CE2 PHE A 206 3.120 3.357 -20.247 1.00 41.13 C \\\\nATOM 1641 CZ PHE A 206 3.318 2.084 -19.694 1.00 41.13 C \\\\nATOM 1642 N PRO A 207 7.522 2.860 -25.663 1.00 35.10 N \\\\nATOM 1643 CA PRO A 207 7.728 2.862 -27.104 1.00 35.10 C \\\\nATOM 1644 C PRO A 207 6.383 2.618 -27.804 1.00 35.10 C \\\\nATOM 1645 CB PRO A 207 8.771 1.770 -27.363 1.00 35.10 C \\\\nATOM 1646 O PRO A 207 5.911 1.486 -27.892 1.00 35.10 O \\\\nATOM 1647 CG PRO A 207 8.559 0.782 -26.214 1.00 35.10 C \\\\nATOM 1648 CD PRO A 207 8.049 1.647 -25.059 1.00 35.10 C \\\\nATOM 1649 N ALA A 208 5.752 3.680 -28.303 1.00 33.84 N \\\\nATOM 1650 CA ALA A 208 4.773 3.562 -29.375 1.00 33.84 C \\\\nATOM 1651 C ALA A 208 5.554 3.220 -30.654 1.00 33.84 C \\\\nATOM 1652 CB ALA A 208 3.977 4.870 -29.479 1.00 33.84 C \\\\nATOM 1653 O ALA A 208 6.194 4.086 -31.242 1.00 33.84 O \\\\nATOM 1654 N GLY A 209 5.598 1.936 -31.016 1.00 29.29 N \\\\nATOM 1655 CA GLY A 209 6.338 1.481 -32.193 1.00 29.29 C \\\\nATOM 1656 C GLY A 209 6.670 -0.006 -32.166 1.00 29.29 C \\\\nATOM 1657 O GLY A 209 7.836 -0.376 -32.081 1.00 29.29 O \\\\nATOM 1658 N ILE A 210 5.653 -0.865 -32.237 1.00 34.22 N \\\\nATOM 1659 CA ILE A 210 5.816 -2.192 -32.838 1.00 34.22 C \\\\nATOM 1660 C ILE A 210 4.875 -2.199 -34.036 1.00 34.22 C \\\\nATOM 1661 CB ILE A 210 5.576 -3.353 -31.843 1.00 34.22 C \\\\nATOM 1662 O ILE A 210 3.655 -2.203 -33.873 1.00 34.22 O \\\\nATOM 1663 CG1 ILE A 210 6.570 -3.264 -30.660 1.00 34.22 C \\\\nATOM 1664 CG2 ILE A 210 5.729 -4.704 -32.570 1.00 34.22 C \\\\nATOM 1665 CD1 ILE A 210 6.384 -4.344 -29.585 1.00 34.22 C \\\\nATOM 1666 N GLU A 211 5.458 -2.118 -35.229 1.00 29.47 N \\\\nATOM 1667 CA GLU A 211 4.771 -2.379 -36.491 1.00 29.47 C \\\\nATOM 1668 C GLU A 211 4.011 -3.714 -36.392 1.00 29.47 C \\\\nATOM 1669 CB GLU A 211 5.802 -2.499 -37.624 1.00 29.47 C \\\\nATOM 1670 O GLU A 211 4.579 -4.702 -35.910 1.00 29.47 O \\\\nATOM 1671 CG GLU A 211 6.550 -1.198 -37.940 1.00 29.47 C \\\\nATOM 1672 CD GLU A 211 7.571 -1.409 -39.071 1.00 29.47 C \\\\nATOM 1673 OE1 GLU A 211 7.591 -0.576 -40.002 1.00 29.47 O \\\\nATOM 1674 OE2 GLU A 211 8.328 -2.405 -38.988 1.00 29.47 O \\\\nATOM 1675 N PRO A 212 2.747 -3.800 -36.837 1.00 32.98 N \\\\nATOM 1676 CA PRO A 212 2.040 -5.065 -36.836 1.00 32.98 C \\\\nATOM 1677 C PRO A 212 2.586 -5.915 -37.986 1.00 32.98 C \\\\nATOM 1678 CB PRO A 212 0.560 -4.696 -36.957 1.00 32.98 C \\\\nATOM 1679 O PRO A 212 2.143 -5.812 -39.129 1.00 32.98 O \\\\nATOM 1680 CG PRO A 212 0.579 -3.395 -37.760 1.00 32.98 C \\\\nATOM 1681 CD PRO A 212 1.919 -2.746 -37.402 1.00 32.98 C \\\\nATOM 1682 N GLN A 213 3.550 -6.788 -37.688 1.00 33.15 N \\\\nATOM 1683 CA GLN A 213 3.832 -7.926 -38.553 1.00 33.15 C \\\\nATOM 1684 C GLN A 213 2.620 -8.861 -38.511 1.00 33.15 C \\\\nATOM 1685 CB GLN A 213 5.141 -8.631 -38.170 1.00 33.15 C \\\\nATOM 1686 O GLN A 213 2.426 -9.630 -37.572 1.00 33.15 O \\\\nATOM 1687 CG GLN A 213 6.360 -7.846 -38.680 1.00 33.15 C \\\\nATOM 1688 CD GLN A 213 7.684 -8.575 -38.463 1.00 33.15 C \\\\nATOM 1689 NE2 GLN A 213 8.735 -8.163 -39.138 1.00 33.15 N \\\\nATOM 1690 OE1 GLN A 213 7.815 -9.515 -37.695 1.00 33.15 O \\\\nATOM 1691 N SER A 214 1.776 -8.698 -39.530 1.00 28.82 N \\\\nATOM 1692 CA SER A 214 0.949 -9.711 -40.183 1.00 28.82 C \\\\nATOM 1693 C SER A 214 0.850 -11.054 -39.449 1.00 28.82 C \\\\nATOM 1694 CB SER A 214 1.532 -9.943 -41.589 1.00 28.82 C \\\\nATOM 1695 O SER A 214 1.736 -11.894 -39.588 1.00 28.82 O \\\\nATOM 1696 OG SER A 214 2.881 -10.376 -41.529 1.00 28.82 O \\\\nATOM 1697 N ASN A 215 -0.261 -11.301 -38.753 1.00 34.40 N \\\\nATOM 1698 CA ASN A 215 -0.771 -12.656 -38.568 1.00 34.40 C \\\\nATOM 1699 C ASN A 215 -2.291 -12.627 -38.360 1.00 34.40 C \\\\nATOM 1700 CB ASN A 215 -0.009 -13.410 -37.457 1.00 34.40 C \\\\nATOM 1701 O ASN A 215 -2.806 -12.058 -37.404 1.00 34.40 O \\\\nATOM 1702 CG ASN A 215 1.130 -14.267 -38.005 1.00 34.40 C \\\\nATOM 1703 ND2 ASN A 215 2.151 -14.511 -37.219 1.00 34.40 N \\\\nATOM 1704 OD1 ASN A 215 1.103 -14.773 -39.116 1.00 34.40 O \\\\nATOM 1705 N TYR A 216 -2.961 -13.225 -39.344 1.00 29.75 N \\\\nATOM 1706 CA TYR A 216 -4.365 -13.598 -39.470 1.00 29.75 C \\\\nATOM 1707 C TYR A 216 -5.182 -13.675 -38.168 1.00 29.75 C \\\\nATOM 1708 CB TYR A 216 -4.356 -14.989 -40.129 1.00 29.75 C \\\\nATOM 1709 O TYR A 216 -4.917 -14.511 -37.307 1.00 29.75 O \\\\nATOM 1710 CG TYR A 216 -4.028 -14.992 -41.611 1.00 29.75 C \\\\nATOM 1711 CD1 TYR A 216 -5.088 -15.091 -42.531 1.00 29.75 C \\\\nATOM 1712 CD2 TYR A 216 -2.697 -14.914 -42.080 1.00 29.75 C \\\\nATOM 1713 CE1 TYR A 216 -4.830 -15.108 -43.913 1.00 29.75 C \\\\nATOM 1714 CE2 TYR A 216 -2.437 -14.907 -43.466 1.00 29.75 C \\\\nATOM 1715 OH TYR A 216 -3.271 -15.017 -45.721 1.00 29.75 O \\\\nATOM 1716 CZ TYR A 216 -3.507 -15.008 -44.384 1.00 29.75 C \\\\nATOM 1717 N ILE A 217 -6.277 -12.912 -38.117 1.00 36.30 N \\\\nATOM 1718 CA ILE A 217 -7.477 -13.261 -37.345 1.00 36.30 C \\\\nATOM 1719 C ILE A 217 -8.657 -13.233 -38.337 1.00 36.30 C \\\\nATOM 1720 CB ILE A 217 -7.702 -12.323 -36.136 1.00 36.30 C \\\\nATOM 1721 O ILE A 217 -8.815 -12.221 -39.022 1.00 36.30 O \\\\nATOM 1722 CG1 ILE A 217 -6.452 -12.275 -35.225 1.00 36.30 C \\\\nATOM 1723 CG2 ILE A 217 -8.930 -12.810 -35.341 1.00 36.30 C \\\\nATOM 1724 CD1 ILE A 217 -6.571 -11.314 -34.035 1.00 36.30 C \\\\nATOM 1725 N PRO A 218 -9.443 -14.318 -38.481 1.00 32.96 N \\\\nATOM 1726 CA PRO A 218 -10.608 -14.346 -39.360 1.00 32.96 C \\\\nATOM 1727 C PRO A 218 -11.803 -13.572 -38.782 1.00 32.96 C \\\\nATOM 1728 CB PRO A 218 -10.946 -15.820 -39.605 1.00 32.96 C \\\\nATOM 1729 O PRO A 218 -11.941 -13.411 -37.572 1.00 32.96 O \\\\nATOM 1730 CG PRO A 218 -10.051 -16.621 -38.658 1.00 32.96 C \\\\nATOM 1731 CD PRO A 218 -9.295 -15.598 -37.813 1.00 32.96 C \\\\nATOM 1732 N GLU A 219 -12.654 -13.127 -39.705 1.00 30.87 N \\\\nATOM 1733 CA GLU A 219 -13.843 -12.283 -39.574 1.00 30.87 C \\\\nATOM 1734 C GLU A 219 -14.855 -12.670 -38.479 1.00 30.87 C \\\\nATOM 1735 CB GLU A 219 -14.609 -12.357 -40.910 1.00 30.87 C \\\\nATOM 1736 O GLU A 219 -15.227 -13.832 -38.327 1.00 30.87 O \\\\nATOM 1737 CG GLU A 219 -13.824 -11.896 -42.144 1.00 30.87 C \\\\nATOM 1738 CD GLU A 219 -14.698 -12.002 -43.401 1.00 30.87 C \\\\nATOM 1739 OE1 GLU A 219 -14.979 -10.943 -44.004 1.00 30.87 O \\\\nATOM 1740 OE2 GLU A 219 -15.076 -13.146 -43.743 1.00 30.87 O \\\\nATOM 1741 N THR A 220 -15.441 -11.649 -37.848 1.00 36.68 N \\\\nATOM 1742 CA THR A 220 -16.836 -11.658 -37.378 1.00 36.68 C \\\\nATOM 1743 C THR A 220 -17.442 -10.258 -37.576 1.00 36.68 C \\\\nATOM 1744 CB THR A 220 -17.000 -12.083 -35.902 1.00 36.68 C \\\\nATOM 1745 O THR A 220 -16.932 -9.297 -36.999 1.00 36.68 O \\\\nATOM 1746 CG2 THR A 220 -17.311 -13.572 -35.758 1.00 36.68 C \\\\nATOM 1747 OG1 THR A 220 -15.859 -11.832 -35.113 1.00 36.68 O \\\\nATOM 1748 N PRO A 221 -18.508 -10.089 -38.385 1.00 42.32 N \\\\nATOM 1749 CA PRO A 221 -19.201 -8.809 -38.514 1.00 42.32 C \\\\nATOM 1750 C PRO A 221 -20.236 -8.633 -37.382 1.00 42.32 C \\\\nATOM 1751 CB PRO A 221 -19.847 -8.851 -39.900 1.00 42.32 C \\\\nATOM 1752 O PRO A 221 -20.784 -9.632 -36.904 1.00 42.32 O \\\\nATOM 1753 CG PRO A 221 -20.189 -10.332 -40.078 1.00 42.32 C \\\\nATOM 1754 CD PRO A 221 -19.111 -11.072 -39.279 1.00 42.32 C \\\\nATOM 1755 N PRO A 222 -20.556 -7.399 -36.941 1.00 47.76 N \\\\nATOM 1756 CA PRO A 222 -21.640 -7.176 -35.990 1.00 47.76 C \\\\nATOM 1757 C PRO A 222 -23.023 -7.337 -36.662 1.00 47.76 C \\\\nATOM 1758 CB PRO A 222 -21.442 -5.774 -35.404 1.00 47.76 C \\\\nATOM 1759 O PRO A 222 -23.148 -7.094 -37.864 1.00 47.76 O \\\\nATOM 1760 CG PRO A 222 -20.184 -5.225 -36.082 1.00 47.76 C \\\\nATOM 1761 CD PRO A 222 -19.949 -6.129 -37.291 1.00 47.76 C \\\\nATOM 1762 N PRO A 223 -24.074 -7.726 -35.913 1.00 42.45 N \\\\nATOM 1763 CA PRO A 223 -25.353 -8.184 -36.465 1.00 42.45 C \\\\nATOM 1764 C PRO A 223 -26.228 -7.049 -37.015 1.00 42.45 C \\\\nATOM 1765 CB PRO A 223 -26.073 -8.914 -35.318 1.00 42.45 C \\\\nATOM 1766 O PRO A 223 -26.425 -6.032 -36.351 1.00 42.45 O \\\\nATOM 1767 CG PRO A 223 -25.013 -9.078 -34.231 1.00 42.45 C \\\\nATOM 1768 CD PRO A 223 -24.088 -7.897 -34.472 1.00 42.45 C \\\\nATOM 1769 N GLY A 224 -26.819 -7.264 -38.195 1.00 31.26 N \\\\nATOM 1770 CA GLY A 224 -27.895 -6.433 -38.735 1.00 31.26 C \\\\nATOM 1771 C GLY A 224 -29.232 -6.735 -38.057 1.00 31.26 C \\\\nATOM 1772 O GLY A 224 -29.611 -7.898 -37.926 1.00 31.26 O \\\\nATOM 1773 N TYR A 225 -29.949 -5.687 -37.649 1.00 42.75 N \\\\nATOM 1774 CA TYR A 225 -31.335 -5.777 -37.197 1.00 42.75 C \\\\nATOM 1775 C TYR A 225 -32.252 -5.158 -38.255 1.00 42.75 C \\\\nATOM 1776 CB TYR A 225 -31.515 -5.177 -35.793 1.00 42.75 C \\\\nATOM 1777 O TYR A 225 -32.238 -3.956 -38.508 1.00 42.75 O \\\\nATOM 1778 CG TYR A 225 -32.127 -6.155 -34.804 1.00 42.75 C \\\\nATOM 1779 CD1 TYR A 225 -33.524 -6.206 -34.627 1.00 42.75 C \\\\nATOM 1780 CD2 TYR A 225 -31.296 -7.033 -34.081 1.00 42.75 C \\\\nATOM 1781 CE1 TYR A 225 -34.087 -7.112 -33.708 1.00 42.75 C \\\\nATOM 1782 CE2 TYR A 225 -31.855 -7.941 -33.160 1.00 42.75 C \\\\nATOM 1783 OH TYR A 225 -33.792 -8.853 -32.080 1.00 42.75 O \\\\nATOM 1784 CZ TYR A 225 -33.252 -7.978 -32.969 1.00 42.75 C \\\\nATOM 1785 N ILE A 226 -32.999 -6.051 -38.888 1.00 36.55 N \\\\nATOM 1786 CA ILE A 226 -34.214 -5.839 -39.670 1.00 36.55 C \\\\nATOM 1787 C ILE A 226 -35.349 -5.370 -38.745 1.00 36.55 C \\\\nATOM 1788 CB ILE A 226 -34.596 -7.182 -40.357 1.00 36.55 C \\\\nATOM 1789 O ILE A 226 -35.517 -5.922 -37.659 1.00 36.55 O \\\\nATOM 1790 CG1 ILE A 226 -34.358 -8.412 -39.430 1.00 36.55 C \\\\nATOM 1791 CG2 ILE A 226 -33.797 -7.334 -41.664 1.00 36.55 C \\\\nATOM 1792 CD1 ILE A 226 -34.952 -9.729 -39.929 1.00 36.55 C \\\\nATOM 1793 N SER A 227 -36.143 -4.400 -39.199 1.00 47.93 N \\\\nATOM 1794 CA SER A 227 -37.483 -4.130 -38.667 1.00 47.93 C \\\\nATOM 1795 C SER A 227 -38.434 -3.907 -39.840 1.00 47.93 C \\\\nATOM 1796 CB SER A 227 -37.516 -2.924 -37.725 1.00 47.93 C \\\\nATOM 1797 O SER A 227 -38.234 -2.993 -40.640 1.00 47.93 O \\\\nATOM 1798 OG SER A 227 -36.754 -3.159 -36.553 1.00 47.93 O \\\\nATOM 1799 N GLU A 228 -39.414 -4.800 -39.935 1.00 46.11 N \\\\nATOM 1800 CA GLU A 228 -40.514 -4.858 -40.896 1.00 46.11 C \\\\nATOM 1801 C GLU A 228 -41.667 -3.894 -40.525 1.00 46.11 C \\\\nATOM 1802 CB GLU A 228 -41.021 -6.321 -40.936 1.00 46.11 C \\\\nATOM 1803 O GLU A 228 -41.901 -3.624 -39.349 1.00 46.11 O \\\\nATOM 1804 CG GLU A 228 -40.045 -7.298 -41.618 1.00 46.11 C \\\\nATOM 1805 CD GLU A 228 -40.428 -8.779 -41.415 1.00 46.11 C \\\\nATOM 1806 OE1 GLU A 228 -40.687 -9.476 -42.424 1.00 46.11 O \\\\nATOM 1807 OE2 GLU A 228 -40.337 -9.242 -40.252 1.00 46.11 O \\\\nATOM 1808 N ASP A 229 -42.363 -3.439 -41.575 1.00 43.27 N \\\\nATOM 1809 CA ASP A 229 -43.800 -3.134 -41.730 1.00 43.27 C \\\\nATOM 1810 C ASP A 229 -44.535 -2.042 -40.918 1.00 43.27 C \\\\nATOM 1811 CB ASP A 229 -44.587 -4.454 -41.742 1.00 43.27 C \\\\nATOM 1812 O ASP A 229 -44.500 -1.981 -39.691 1.00 43.27 O \\\\nATOM 1813 CG ASP A 229 -44.099 -5.419 -42.832 1.00 43.27 C \\\\nATOM 1814 OD1 ASP A 229 -43.547 -4.923 -43.845 1.00 43.27 O \\\\nATOM 1815 OD2 ASP A 229 -44.293 -6.638 -42.646 1.00 43.27 O \\\\nATOM 1816 N GLY A 230 -45.339 -1.235 -41.644 1.00 41.83 N \\\\nATOM 1817 CA GLY A 230 -46.419 -0.420 -41.058 1.00 41.83 C \\\\nATOM 1818 C GLY A 230 -46.959 0.792 -41.851 1.00 41.83 C \\\\nATOM 1819 O GLY A 230 -46.917 1.899 -41.337 1.00 41.83 O \\\\nATOM 1820 N GLU A 231 -47.436 0.576 -43.083 1.00 42.15 N \\\\nATOM 1821 CA GLU A 231 -48.653 1.121 -43.747 1.00 42.15 C \\\\nATOM 1822 C GLU A 231 -49.152 2.603 -43.629 1.00 42.15 C \\\\nATOM 1823 CB GLU A 231 -49.811 0.155 -43.417 1.00 42.15 C \\\\nATOM 1824 O GLU A 231 -49.428 3.117 -42.550 1.00 42.15 O \\\\nATOM 1825 CG GLU A 231 -49.540 -1.282 -43.904 1.00 42.15 C \\\\nATOM 1826 CD GLU A 231 -50.767 -2.196 -43.772 1.00 42.15 C \\\\nATOM 1827 OE1 GLU A 231 -51.040 -2.932 -44.747 1.00 42.15 O \\\\nATOM 1828 OE2 GLU A 231 -51.429 -2.146 -42.712 1.00 42.15 O \\\\nATOM 1829 N THR A 232 -49.529 3.161 -44.808 1.00 42.91 N \\\\nATOM 1830 CA THR A 232 -50.599 4.171 -45.128 1.00 42.91 C \\\\nATOM 1831 C THR A 232 -50.304 5.675 -44.888 1.00 42.91 C \\\\nATOM 1832 CB THR A 232 -51.949 3.746 -44.514 1.00 42.91 C \\\\nATOM 1833 O THR A 232 -49.792 6.040 -43.845 1.00 42.91 O \\\\nATOM 1834 CG2 THR A 232 -52.463 2.399 -45.036 1.00 42.91 C \\\\nATOM 1835 OG1 THR A 232 -51.949 3.754 -43.110 1.00 42.91 O \\\\nATOM 1836 N SER A 233 -50.593 6.665 -45.754 1.00 42.08 N \\\\nATOM 1837 CA SER A 233 -51.392 6.803 -46.990 1.00 42.08 C \\\\nATOM 1838 C SER A 233 -50.855 7.944 -47.882 1.00 42.08 C \\\\nATOM 1839 CB SER A 233 -52.827 7.235 -46.655 1.00 42.08 C \\\\nATOM 1840 O SER A 233 -50.367 8.956 -47.382 1.00 42.08 O \\\\nATOM 1841 OG SER A 233 -53.568 6.191 -46.074 1.00 42.08 O \\\\nATOM 1842 N ASP A 234 -51.034 7.784 -49.195 1.00 37.27 N \\\\nATOM 1843 CA ASP A 234 -50.823 8.764 -50.269 1.00 37.27 C \\\\nATOM 1844 C ASP A 234 -51.973 9.792 -50.428 1.00 37.27 C \\\\nATOM 1845 CB ASP A 234 -50.708 7.975 -51.598 1.00 37.27 C \\\\nATOM 1846 O ASP A 234 -53.094 9.568 -49.971 1.00 37.27 O \\\\nATOM 1847 CG ASP A 234 -49.301 7.534 -51.967 1.00 37.27 C \\\\nATOM 1848 OD1 ASP A 234 -48.425 8.425 -51.963 1.00 37.27 O \\\\nATOM 1849 OD2 ASP A 234 -49.159 6.359 -52.367 1.00 37.27 O \\\\nATOM 1850 N GLN A 235 -51.692 10.795 -51.282 1.00 43.07 N \\\\nATOM 1851 CA GLN A 235 -52.589 11.706 -52.035 1.00 43.07 C \\\\nATOM 1852 C GLN A 235 -52.955 13.016 -51.294 1.00 43.07 C \\\\nATOM 1853 CB GLN A 235 -53.801 10.947 -52.638 1.00 43.07 C \\\\nATOM 1854 O GLN A 235 -53.390 12.989 -50.157 1.00 43.07 O \\\\nATOM 1855 CG GLN A 235 -53.418 9.621 -53.332 1.00 43.07 C \\\\nATOM 1856 CD GLN A 235 -54.524 8.941 -54.125 1.00 43.07 C \\\\nATOM 1857 NE2 GLN A 235 -54.307 7.709 -54.536 1.00 43.07 N \\\\nATOM 1858 OE1 GLN A 235 -55.570 9.491 -54.427 1.00 43.07 O \\\\nATOM 1859 N GLN A 236 -52.828 14.231 -51.848 1.00 40.77 N \\\\nATOM 1860 CA GLN A 236 -53.079 14.661 -53.225 1.00 40.77 C \\\\nATOM 1861 C GLN A 236 -52.575 16.115 -53.450 1.00 40.77 C \\\\nATOM 1862 CB GLN A 236 -54.617 14.612 -53.409 1.00 40.77 C \\\\nATOM 1863 O GLN A 236 -52.714 16.948 -52.564 1.00 40.77 O \\\\nATOM 1864 CG GLN A 236 -55.092 14.033 -54.742 1.00 40.77 C \\\\nATOM 1865 CD GLN A 236 -56.567 13.641 -54.715 1.00 40.77 C \\\\nATOM 1866 NE2 GLN A 236 -57.005 12.779 -55.602 1.00 40.77 N \\\\nATOM 1867 OE1 GLN A 236 -57.365 14.104 -53.921 1.00 40.77 O \\\\nATOM 1868 N LEU A 237 -51.998 16.353 -54.642 1.00 40.25 N \\\\nATOM 1869 CA LEU A 237 -51.968 17.543 -55.533 1.00 40.25 C \\\\nATOM 1870 C LEU A 237 -52.324 18.968 -55.019 1.00 40.25 C \\\\nATOM 1871 CB LEU A 237 -52.972 17.219 -56.665 1.00 40.25 C \\\\nATOM 1872 O LEU A 237 -53.214 19.127 -54.205 1.00 40.25 O \\\\nATOM 1873 CG LEU A 237 -52.494 16.164 -57.685 1.00 40.25 C \\\\nATOM 1874 CD1 LEU A 237 -53.184 14.814 -57.499 1.00 40.25 C \\\\nATOM 1875 CD2 LEU A 237 -52.813 16.621 -59.108 1.00 40.25 C \\\\nATOM 1876 N ASN A 238 -51.915 20.102 -55.611 1.00 38.01 N \\\\nATOM 1877 CA ASN A 238 -50.938 20.586 -56.609 1.00 38.01 C \\\\nATOM 1878 C ASN A 238 -51.364 22.056 -56.911 1.00 38.01 C \\\\nATOM 1879 CB ASN A 238 -50.998 19.776 -57.931 1.00 38.01 C \\\\nATOM 1880 O ASN A 238 -52.565 22.311 -56.914 1.00 38.01 O \\\\nATOM 1881 CG ASN A 238 -49.783 19.919 -58.827 1.00 38.01 C \\\\nATOM 1882 ND2 ASN A 238 -49.811 19.335 -60.006 1.00 38.01 N \\\\nATOM 1883 OD1 ASN A 238 -48.781 20.517 -58.487 1.00 38.01 O \\\\nATOM 1884 N GLN A 239 -50.420 22.937 -57.292 1.00 40.11 N \\\\nATOM 1885 CA GLN A 239 -50.619 24.237 -58.001 1.00 40.11 C \\\\nATOM 1886 C GLN A 239 -51.303 25.383 -57.200 1.00 40.11 C \\\\nATOM 1887 CB GLN A 239 -51.318 23.941 -59.348 1.00 40.11 C \\\\nATOM 1888 O GLN A 239 -52.139 25.132 -56.350 1.00 40.11 O \\\\nATOM 1889 CG GLN A 239 -50.440 23.130 -60.314 1.00 40.11 C \\\\nATOM 1890 CD GLN A 239 -51.238 22.565 -61.483 1.00 40.11 C \\\\nATOM 1891 NE2 GLN A 239 -51.226 21.271 -61.713 1.00 40.11 N \\\\nATOM 1892 OE1 GLN A 239 -51.873 23.269 -62.241 1.00 40.11 O \\\\nATOM 1893 N SER A 240 -51.038 26.686 -57.365 1.00 43.35 N \\\\nATOM 1894 CA SER A 240 -50.202 27.499 -58.269 1.00 43.35 C \\\\nATOM 1895 C SER A 240 -50.144 28.959 -57.738 1.00 43.35 C \\\\nATOM 1896 CB SER A 240 -50.762 27.509 -59.706 1.00 43.35 C \\\\nATOM 1897 O SER A 240 -50.901 29.325 -56.844 1.00 43.35 O \\\\nATOM 1898 OG SER A 240 -52.158 27.305 -59.748 1.00 43.35 O \\\\nATOM 1899 N MET A 241 -49.217 29.754 -58.286 1.00 42.24 N \\\\nATOM 1900 CA MET A 241 -48.848 31.152 -57.975 1.00 42.24 C \\\\nATOM 1901 C MET A 241 -49.996 32.180 -58.075 1.00 42.24 C \\\\nATOM 1902 CB MET A 241 -47.796 31.564 -59.029 1.00 42.24 C \\\\nATOM 1903 O MET A 241 -50.863 32.002 -58.918 1.00 42.24 O \\\\nATOM 1904 CG MET A 241 -46.510 30.723 -59.019 1.00 42.24 C \\\\nATOM 1905 SD MET A 241 -45.467 30.947 -60.489 1.00 42.24 S \\\\nATOM 1906 CE MET A 241 -44.030 29.949 -60.015 1.00 42.24 C \\\\nATOM 1907 N ASP A 242 -49.936 33.283 -57.305 1.00 40.97 N \\\\nATOM 1908 CA ASP A 242 -49.971 34.649 -57.871 1.00 40.97 C \\\\nATOM 1909 C ASP A 242 -49.706 35.794 -56.863 1.00 40.97 C \\\\nATOM 1910 CB ASP A 242 -51.237 34.953 -58.711 1.00 40.97 C \\\\nATOM 1911 O ASP A 242 -49.965 35.727 -55.664 1.00 40.97 O \\\\nATOM 1912 CG ASP A 242 -51.029 34.730 -60.222 1.00 40.97 C \\\\nATOM 1913 OD1 ASP A 242 -49.864 34.851 -60.676 1.00 40.97 O \\\\nATOM 1914 OD2 ASP A 242 -52.042 34.530 -60.928 1.00 40.97 O \\\\nATOM 1915 N THR A 243 -49.128 36.839 -57.450 1.00 38.70 N \\\\nATOM 1916 CA THR A 243 -48.641 38.169 -57.038 1.00 38.70 C \\\\nATOM 1917 C THR A 243 -49.545 39.095 -56.201 1.00 38.70 C \\\\nATOM 1918 CB THR A 243 -48.421 38.931 -58.366 1.00 38.70 C \\\\nATOM 1919 O THR A 243 -50.746 39.164 -56.437 1.00 38.70 O \\\\nATOM 1920 CG2 THR A 243 -47.054 38.660 -58.985 1.00 38.70 C \\\\nATOM 1921 OG1 THR A 243 -49.362 38.545 -59.348 1.00 38.70 O \\\\nATOM 1922 N GLY A 244 -48.926 39.973 -55.383 1.00 39.50 N \\\\nATOM 1923 CA GLY A 244 -49.496 41.283 -54.995 1.00 39.50 C \\\\nATOM 1924 C GLY A 244 -49.025 41.882 -53.651 1.00 39.50 C \\\\nATOM 1925 O GLY A 244 -49.585 41.568 -52.609 1.00 39.50 O \\\\nATOM 1926 N SER A 245 -48.027 42.774 -53.675 1.00 42.65 N \\\\nATOM 1927 CA SER A 245 -47.559 43.641 -52.560 1.00 42.65 C \\\\nATOM 1928 C SER A 245 -48.484 44.872 -52.339 1.00 42.65 C \\\\nATOM 1929 CB SER A 245 -46.157 44.149 -52.950 1.00 42.65 C \\\\nATOM 1930 O SER A 245 -49.369 45.087 -53.164 1.00 42.65 O \\\\nATOM 1931 OG SER A 245 -45.287 43.109 -53.350 1.00 42.65 O \\\\nATOM 1932 N PRO A 246 -48.160 45.856 -51.462 1.00 43.21 N \\\\nATOM 1933 CA PRO A 246 -47.896 45.842 -50.010 1.00 43.21 C \\\\nATOM 1934 C PRO A 246 -48.722 46.921 -49.241 1.00 43.21 C \\\\nATOM 1935 CB PRO A 246 -46.411 46.213 -49.915 1.00 43.21 C \\\\nATOM 1936 O PRO A 246 -49.145 47.911 -49.832 1.00 43.21 O \\\\nATOM 1937 CG PRO A 246 -46.212 47.195 -51.082 1.00 43.21 C \\\\nATOM 1938 CD PRO A 246 -47.416 46.984 -52.009 1.00 43.21 C \\\\nATOM 1939 N ALA A 247 -48.870 46.811 -47.911 1.00 43.57 N \\\\nATOM 1940 CA ALA A 247 -49.324 47.925 -47.059 1.00 43.57 C \\\\nATOM 1941 C ALA A 247 -48.847 47.812 -45.588 1.00 43.57 C \\\\nATOM 1942 CB ALA A 247 -50.855 48.047 -47.127 1.00 43.57 C \\\\nATOM 1943 O ALA A 247 -49.112 46.824 -44.914 1.00 43.57 O \\\\nATOM 1944 N GLU A 248 -48.155 48.869 -45.145 1.00 39.39 N \\\\nATOM 1945 CA GLU A 248 -48.252 49.554 -43.837 1.00 39.39 C \\\\nATOM 1946 C GLU A 248 -47.778 48.893 -42.512 1.00 39.39 C \\\\nATOM 1947 CB GLU A 248 -49.618 50.255 -43.728 1.00 39.39 C \\\\nATOM 1948 O GLU A 248 -48.478 48.144 -41.844 1.00 39.39 O \\\\nATOM 1949 CG GLU A 248 -49.804 51.247 -44.896 1.00 39.39 C \\\\nATOM 1950 CD GLU A 248 -51.023 52.160 -44.732 1.00 39.39 C \\\\nATOM 1951 OE1 GLU A 248 -50.856 53.370 -45.004 1.00 39.39 O \\\\nATOM 1952 OE2 GLU A 248 -52.101 51.647 -44.362 1.00 39.39 O \\\\nATOM 1953 N LEU A 249 -46.569 49.313 -42.100 1.00 41.33 N \\\\nATOM 1954 CA LEU A 249 -46.170 49.896 -40.798 1.00 41.33 C \\\\nATOM 1955 C LEU A 249 -46.823 49.398 -39.486 1.00 41.33 C \\\\nATOM 1956 CB LEU A 249 -46.370 51.429 -40.891 1.00 41.33 C \\\\nATOM 1957 O LEU A 249 -47.955 49.752 -39.176 1.00 41.33 O \\\\nATOM 1958 CG LEU A 249 -45.467 52.162 -41.899 1.00 41.33 C \\\\nATOM 1959 CD1 LEU A 249 -46.013 53.561 -42.181 1.00 41.33 C \\\\nATOM 1960 CD2 LEU A 249 -44.037 52.303 -41.372 1.00 41.33 C \\\\nATOM 1961 N SER A 250 -46.004 48.805 -38.602 1.00 40.23 N \\\\nATOM 1962 CA SER A 250 -45.986 49.060 -37.140 1.00 40.23 C \\\\nATOM 1963 C SER A 250 -44.722 48.453 -36.493 1.00 40.23 C \\\\nATOM 1964 CB SER A 250 -47.207 48.455 -36.435 1.00 40.23 C \\\\nATOM 1965 O SER A 250 -44.469 47.267 -36.697 1.00 40.23 O \\\\nATOM 1966 OG SER A 250 -48.333 49.282 -36.627 1.00 40.23 O \\\\nATOM 1967 N PRO A 251 -43.913 49.201 -35.712 1.00 37.55 N \\\\nATOM 1968 CA PRO A 251 -42.774 48.652 -34.979 1.00 37.55 C \\\\nATOM 1969 C PRO A 251 -43.180 48.301 -33.541 1.00 37.55 C \\\\nATOM 1970 CB PRO A 251 -41.722 49.764 -35.026 1.00 37.55 C \\\\nATOM 1971 O PRO A 251 -43.771 49.122 -32.841 1.00 37.55 O \\\\nATOM 1972 CG PRO A 251 -42.560 51.046 -34.979 1.00 37.55 C \\\\nATOM 1973 CD PRO A 251 -43.921 50.653 -35.571 1.00 37.55 C \\\\nATOM 1974 N THR A 252 -42.853 47.104 -33.053 1.00 40.99 N \\\\nATOM 1975 CA THR A 252 -42.973 46.801 -31.617 1.00 40.99 C \\\\nATOM 1976 C THR A 252 -41.962 45.744 -31.171 1.00 40.99 C \\\\nATOM 1977 CB THR A 252 -44.410 46.432 -31.164 1.00 40.99 C \\\\nATOM 1978 O THR A 252 -42.014 44.586 -31.566 1.00 40.99 O \\\\nATOM 1979 CG2 THR A 252 -44.923 47.403 -30.096 1.00 40.99 C \\\\nATOM 1980 OG1 THR A 252 -45.352 46.526 -32.205 1.00 40.99 O \\\\nATOM 1981 N THR A 253 -41.062 46.204 -30.295 1.00 40.72 N \\\\nATOM 1982 CA THR A 253 -40.430 45.482 -29.175 1.00 40.72 C \\\\nATOM 1983 C THR A 253 -39.524 44.280 -29.471 1.00 40.72 C \\\\nATOM 1984 CB THR A 253 -41.461 45.163 -28.079 1.00 40.72 C \\\\nATOM 1985 O THR A 253 -39.961 43.140 -29.593 1.00 40.72 O \\\\nATOM 1986 CG2 THR A 253 -41.946 46.453 -27.410 1.00 40.72 C \\\\nATOM 1987 OG1 THR A 253 -42.597 44.519 -28.600 1.00 40.72 O \\\\nATOM 1988 N LEU A 254 -38.216 44.561 -29.424 1.00 39.36 N \\\\nATOM 1989 CA LEU A 254 -37.133 43.610 -29.166 1.00 39.36 C \\\\nATOM 1990 C LEU A 254 -37.409 42.817 -27.876 1.00 39.36 C \\\\nATOM 1991 CB LEU A 254 -35.824 44.415 -29.003 1.00 39.36 C \\\\nATOM 1992 O LEU A 254 -37.460 43.395 -26.791 1.00 39.36 O \\\\nATOM 1993 CG LEU A 254 -35.280 45.017 -30.315 1.00 39.36 C \\\\nATOM 1994 CD1 LEU A 254 -34.831 46.466 -30.117 1.00 39.36 C \\\\nATOM 1995 CD2 LEU A 254 -34.086 44.210 -30.824 1.00 39.36 C \\\\nATOM 1996 N SER A 255 -37.551 41.499 -28.001 1.00 41.25 N \\\\nATOM 1997 CA SER A 255 -37.453 40.555 -26.882 1.00 41.25 C \\\\nATOM 1998 C SER A 255 -36.006 40.052 -26.797 1.00 41.25 C \\\\nATOM 1999 CB SER A 255 -38.413 39.381 -27.082 1.00 41.25 C \\\\nATOM 2000 O SER A 255 -35.414 39.783 -27.845 1.00 41.25 O \\\\nATOM 2001 OG SER A 255 -39.740 39.860 -27.175 1.00 41.25 O \\\\nATOM 2002 N PRO A 256 -35.403 39.934 -25.602 1.00 41.93 N \\\\nATOM 2003 CA PRO A 256 -34.027 39.477 -25.476 1.00 41.93 C \\\\nATOM 2004 C PRO A 256 -33.949 37.988 -25.824 1.00 41.93 C \\\\nATOM 2005 CB PRO A 256 -33.620 39.791 -24.034 1.00 41.93 C \\\\nATOM 2006 O PRO A 256 -34.719 37.173 -25.314 1.00 41.93 O \\\\nATOM 2007 CG PRO A 256 -34.942 39.739 -23.267 1.00 41.93 C \\\\nATOM 2008 CD PRO A 256 -35.998 40.152 -24.294 1.00 41.93 C \\\\nATOM 2009 N VAL A 257 -33.012 37.640 -26.704 1.00 38.71 N \\\\nATOM 2010 CA VAL A 257 -32.677 36.258 -27.054 1.00 38.71 C \\\\nATOM 2011 C VAL A 257 -32.097 35.594 -25.803 1.00 38.71 C \\\\nATOM 2012 CB VAL A 257 -31.690 36.217 -28.246 1.00 38.71 C \\\\nATOM 2013 O VAL A 257 -30.939 35.808 -25.450 1.00 38.71 O \\\\nATOM 2014 CG1 VAL A 257 -31.494 34.785 -28.757 1.00 38.71 C \\\\nATOM 2015 CG2 VAL A 257 -32.192 37.068 -29.424 1.00 38.71 C \\\\nATOM 2016 N ASN A 258 -32.916 34.816 -25.092 1.00 38.20 N \\\\nATOM 2017 CA ASN A 258 -32.433 33.894 -24.070 1.00 38.20 C \\\\nATOM 2018 C ASN A 258 -31.664 32.778 -24.786 1.00 38.20 C \\\\nATOM 2019 CB ASN A 258 -33.611 33.347 -23.225 1.00 38.20 C \\\\nATOM 2020 O ASN A 258 -32.248 31.774 -25.190 1.00 38.20 O \\\\nATOM 2021 CG ASN A 258 -33.801 34.022 -21.876 1.00 38.20 C \\\\nATOM 2022 ND2 ASN A 258 -34.835 33.652 -21.157 1.00 38.20 N \\\\nATOM 2023 OD1 ASN A 258 -33.028 34.845 -21.420 1.00 38.20 O \\\\nATOM 2024 N HIS A 259 -30.350 32.941 -24.936 1.00 43.97 N \\\\nATOM 2025 CA HIS A 259 -29.453 31.814 -25.172 1.00 43.97 C \\\\nATOM 2026 C HIS A 259 -29.431 30.956 -23.899 1.00 43.97 C \\\\nATOM 2027 CB HIS A 259 -28.052 32.306 -25.574 1.00 43.97 C \\\\nATOM 2028 O HIS A 259 -28.532 31.072 -23.068 1.00 43.97 O \\\\nATOM 2029 CG HIS A 259 -27.983 32.894 -26.961 1.00 43.97 C \\\\nATOM 2030 CD2 HIS A 259 -27.892 34.221 -27.283 1.00 43.97 C \\\\nATOM 2031 ND1 HIS A 259 -27.951 32.189 -28.145 1.00 43.97 N \\\\nATOM 2032 CE1 HIS A 259 -27.839 33.070 -29.153 1.00 43.97 C \\\\nATOM 2033 NE2 HIS A 259 -27.810 34.324 -28.674 1.00 43.97 N \\\\nATOM 2034 N SER A 260 -30.452 30.116 -23.702 1.00 46.85 N \\\\nATOM 2035 CA SER A 260 -30.347 29.020 -22.745 1.00 46.85 C \\\\nATOM 2036 C SER A 260 -29.341 28.033 -23.325 1.00 46.85 C \\\\nATOM 2037 CB SER A 260 -31.703 28.365 -22.442 1.00 46.85 C \\\\nATOM 2038 O SER A 260 -29.677 27.256 -24.218 1.00 46.85 O \\\\nATOM 2039 OG SER A 260 -32.255 27.717 -23.567 1.00 46.85 O \\\\nATOM 2040 N LEU A 261 -28.090 28.107 -22.870 1.00 57.93 N \\\\nATOM 2041 CA LEU A 261 -27.111 27.052 -23.102 1.00 57.93 C \\\\nATOM 2042 C LEU A 261 -27.748 25.739 -22.633 1.00 57.93 C \\\\nATOM 2043 CB LEU A 261 -25.818 27.369 -22.324 1.00 57.93 C \\\\nATOM 2044 O LEU A 261 -28.035 25.584 -21.445 1.00 57.93 O \\\\nATOM 2045 CG LEU A 261 -25.012 28.555 -22.887 1.00 57.93 C \\\\nATOM 2046 CD1 LEU A 261 -23.962 29.004 -21.869 1.00 57.93 C \\\\nATOM 2047 CD2 LEU A 261 -24.291 28.181 -24.185 1.00 57.93 C \\\\nATOM 2048 N ASP A 262 -28.031 24.838 -23.573 1.00 70.10 N \\\\nATOM 2049 CA ASP A 262 -28.588 23.519 -23.283 1.00 70.10 C \\\\nATOM 2050 C ASP A 262 -27.473 22.683 -22.635 1.00 70.10 C \\\\nATOM 2051 CB ASP A 262 -29.195 22.914 -24.566 1.00 70.10 C \\\\nATOM 2052 O ASP A 262 -26.625 22.085 -23.302 1.00 70.10 O \\\\nATOM 2053 CG ASP A 262 -30.120 21.714 -24.313 1.00 70.10 C \\\\nATOM 2054 OD1 ASP A 262 -30.649 21.595 -23.187 1.00 70.10 O \\\\nATOM 2055 OD2 ASP A 262 -30.301 20.904 -25.257 1.00 70.10 O \\\\nATOM 2056 N LEU A 263 -27.388 22.779 -21.307 1.00 79.04 N \\\\nATOM 2057 CA LEU A 263 -26.398 22.100 -20.479 1.00 79.04 C \\\\nATOM 2058 C LEU A 263 -26.907 20.697 -20.144 1.00 79.04 C \\\\nATOM 2059 CB LEU A 263 -26.142 22.921 -19.199 1.00 79.04 C \\\\nATOM 2060 O LEU A 263 -27.904 20.543 -19.438 1.00 79.04 O \\\\nATOM 2061 CG LEU A 263 -25.343 24.222 -19.402 1.00 79.04 C \\\\nATOM 2062 CD1 LEU A 263 -25.410 25.078 -18.136 1.00 79.04 C \\\\nATOM 2063 CD2 LEU A 263 -23.866 23.953 -19.694 1.00 79.04 C \\\\nATOM 2064 N GLN A 264 -26.191 19.668 -20.593 1.00 82.84 N \\\\nATOM 2065 CA GLN A 264 -26.520 18.281 -20.275 1.00 82.84 C \\\\nATOM 2066 C GLN A 264 -25.827 17.858 -18.964 1.00 82.84 C \\\\nATOM 2067 CB GLN A 264 -26.128 17.375 -21.451 1.00 82.84 C \\\\nATOM 2068 O GLN A 264 -24.595 17.875 -18.900 1.00 82.84 O \\\\nATOM 2069 CG GLN A 264 -26.586 15.919 -21.255 1.00 82.84 C \\\\nATOM 2070 CD GLN A 264 -28.099 15.731 -21.323 1.00 82.84 C \\\\nATOM 2071 NE2 GLN A 264 -28.653 14.767 -20.625 1.00 82.84 N \\\\nATOM 2072 OE1 GLN A 264 -28.816 16.404 -22.041 1.00 82.84 O \\\\nATOM 2073 N PRO A 265 -26.566 17.436 -17.920 1.00 88.13 N \\\\nATOM 2074 CA PRO A 265 -25.963 16.916 -16.697 1.00 88.13 C \\\\nATOM 2075 C PRO A 265 -25.456 15.478 -16.887 1.00 88.13 C \\\\nATOM 2076 CB PRO A 265 -27.061 17.016 -15.634 1.00 88.13 C \\\\nATOM 2077 O PRO A 265 -26.204 14.589 -17.296 1.00 88.13 O \\\\nATOM 2078 CG PRO A 265 -28.351 16.862 -16.442 1.00 88.13 C \\\\nATOM 2079 CD PRO A 265 -28.015 17.515 -17.783 1.00 88.13 C \\\\nATOM 2080 N VAL A 266 -24.196 15.235 -16.522 1.00 88.49 N \\\\nATOM 2081 CA VAL A 266 -23.542 13.920 -16.544 1.00 88.49 C \\\\nATOM 2082 C VAL A 266 -23.222 13.471 -15.117 1.00 88.49 C \\\\nATOM 2083 CB VAL A 266 -22.277 13.943 -17.424 1.00 88.49 C \\\\nATOM 2084 O VAL A 266 -22.374 14.053 -14.434 1.00 88.49 O \\\\nATOM 2085 CG1 VAL A 266 -21.631 12.554 -17.454 1.00 88.49 C \\\\nATOM 2086 CG2 VAL A 266 -22.603 14.340 -18.870 1.00 88.49 C \\\\nATOM 2087 N THR A 267 -23.899 12.416 -14.658 1.00 89.40 N \\\\nATOM 2088 CA THR A 267 -23.777 11.883 -13.292 1.00 89.40 C \\\\nATOM 2089 C THR A 267 -22.712 10.789 -13.167 1.00 89.40 C \\\\nATOM 2090 CB THR A 267 -25.125 11.358 -12.769 1.00 89.40 C \\\\nATOM 2091 O THR A 267 -22.523 9.952 -14.059 1.00 89.40 O \\\\nATOM 2092 CG2 THR A 267 -26.161 12.469 -12.601 1.00 89.40 C \\\\nATOM 2093 OG1 THR A 267 -25.678 10.415 -13.657 1.00 89.40 O \\\\nATOM 2094 N TYR A 268 -22.040 10.769 -12.013 1.00 89.45 N \\\\nATOM 2095 CA TYR A 268 -21.136 9.689 -11.622 1.00 89.45 C \\\\nATOM 2096 C TYR A 268 -21.918 8.409 -11.295 1.00 89.45 C \\\\nATOM 2097 CB TYR A 268 -20.292 10.126 -10.418 1.00 89.45 C \\\\nATOM 2098 O TYR A 268 -22.978 8.457 -10.670 1.00 89.45 O \\\\nATOM 2099 CG TYR A 268 -19.250 9.105 -9.993 1.00 89.45 C \\\\nATOM 2100 CD1 TYR A 268 -19.514 8.182 -8.961 1.00 89.45 C \\\\nATOM 2101 CD2 TYR A 268 -18.001 9.084 -10.631 1.00 89.45 C \\\\nATOM 2102 CE1 TYR A 268 -18.526 7.253 -8.569 1.00 89.45 C \\\\nATOM 2103 CE2 TYR A 268 -17.000 8.186 -10.220 1.00 89.45 C \\\\nATOM 2104 OH TYR A 268 -16.280 6.389 -8.811 1.00 89.45 O \\\\nATOM 2105 CZ TYR A 268 -17.259 7.256 -9.192 1.00 89.45 C \\\\nATOM 2106 N SER A 269 -21.368 7.259 -11.680 1.00 85.81 N \\\\nATOM 2107 CA SER A 269 -21.863 5.937 -11.292 1.00 85.81 C \\\\nATOM 2108 C SER A 269 -20.695 5.073 -10.841 1.00 85.81 C \\\\nATOM 2109 CB SER A 269 -22.624 5.259 -12.439 1.00 85.81 C \\\\nATOM 2110 O SER A 269 -19.671 5.038 -11.516 1.00 85.81 O \\\\nATOM 2111 OG SER A 269 -21.890 5.242 -13.658 1.00 85.81 O \\\\nATOM 2112 N GLU A 270 -20.845 4.374 -9.718 1.00 86.25 N \\\\nATOM 2113 CA GLU A 270 -19.789 3.501 -9.206 1.00 86.25 C \\\\nATOM 2114 C GLU A 270 -19.738 2.192 -10.023 1.00 86.25 C \\\\nATOM 2115 CB GLU A 270 -20.010 3.232 -7.709 1.00 86.25 C \\\\nATOM 2116 O GLU A 270 -20.766 1.516 -10.152 1.00 86.25 O \\\\nATOM 2117 CG GLU A 270 -18.728 2.796 -6.984 1.00 86.25 C \\\\nATOM 2118 CD GLU A 270 -17.764 3.974 -6.775 1.00 86.25 C \\\\nATOM 2119 OE1 GLU A 270 -16.707 4.031 -7.432 1.00 86.25 O \\\\nATOM 2120 OE2 GLU A 270 -18.057 4.870 -5.955 1.00 86.25 O \\\\nATOM 2121 N PRO A 271 -18.581 1.815 -10.592 1.00 91.14 N \\\\nATOM 2122 CA PRO A 271 -18.441 0.578 -11.353 1.00 91.14 C \\\\nATOM 2123 C PRO A 271 -18.353 -0.655 -10.440 1.00 91.14 C \\\\nATOM 2124 CB PRO A 271 -17.169 0.768 -12.180 1.00 91.14 C \\\\nATOM 2125 O PRO A 271 -17.957 -0.569 -9.280 1.00 91.14 O \\\\nATOM 2126 CG PRO A 271 -16.321 1.650 -11.272 1.00 91.14 C \\\\nATOM 2127 CD PRO A 271 -17.340 2.574 -10.621 1.00 91.14 C \\\\nATOM 2128 N ALA A 272 -18.644 -1.837 -10.995 1.00 89.84 N \\\\nATOM 2129 CA ALA A 272 -18.530 -3.114 -10.275 1.00 89.84 C \\\\nATOM 2130 C ALA A 272 -17.092 -3.431 -9.816 1.00 89.84 C \\\\nATOM 2131 CB ALA A 272 -19.057 -4.227 -11.189 1.00 89.84 C \\\\nATOM 2132 O ALA A 272 -16.889 -4.063 -8.781 1.00 89.84 O \\\\nATOM 2133 N PHE A 273 -16.099 -2.982 -10.588 1.00 94.27 N \\\\nATOM 2134 CA PHE A 273 -14.688 -3.017 -10.220 1.00 94.27 C \\\\nATOM 2135 C PHE A 273 -14.194 -1.585 -10.114 1.00 94.27 C \\\\nATOM 2136 CB PHE A 273 -13.874 -3.797 -11.260 1.00 94.27 C \\\\nATOM 2137 O PHE A 273 -14.209 -0.868 -11.114 1.00 94.27 O \\\\nATOM 2138 CG PHE A 273 -14.326 -5.227 -11.449 1.00 94.27 C \\\\nATOM 2139 CD1 PHE A 273 -13.887 -6.225 -10.564 1.00 94.27 C \\\\nATOM 2140 CD2 PHE A 273 -15.184 -5.565 -12.512 1.00 94.27 C \\\\nATOM 2141 CE1 PHE A 273 -14.299 -7.557 -10.732 1.00 94.27 C \\\\nATOM 2142 CE2 PHE A 273 -15.603 -6.897 -12.679 1.00 94.27 C \\\\nATOM 2143 CZ PHE A 273 -15.162 -7.892 -11.790 1.00 94.27 C \\\\nATOM 2144 N TRP A 274 -13.742 -1.160 -8.939 1.00 95.07 N \\\\nATOM 2145 CA TRP A 274 -13.333 0.229 -8.720 1.00 95.07 C \\\\nATOM 2146 C TRP A 274 -11.968 0.541 -9.349 1.00 95.07 C \\\\nATOM 2147 CB TRP A 274 -13.369 0.531 -7.223 1.00 95.07 C \\\\nATOM 2148 O TRP A 274 -11.717 1.679 -9.749 1.00 95.07 O \\\\nATOM 2149 CG TRP A 274 -12.348 -0.198 -6.411 1.00 95.07 C \\\\nATOM 2150 CD1 TRP A 274 -12.518 -1.390 -5.799 1.00 95.07 C \\\\nATOM 2151 CD2 TRP A 274 -10.987 0.221 -6.105 1.00 95.07 C \\\\nATOM 2152 CE2 TRP A 274 -10.390 -0.761 -5.262 1.00 95.07 C \\\\nATOM 2153 CE3 TRP A 274 -10.209 1.350 -6.438 1.00 95.07 C \\\\nATOM 2154 NE1 TRP A 274 -11.364 -1.725 -5.122 1.00 95.07 N \\\\nATOM 2155 CH2 TRP A 274 -8.338 0.512 -5.116 1.00 95.07 C \\\\nATOM 2156 CZ2 TRP A 274 -9.095 -0.612 -4.746 1.00 95.07 C \\\\nATOM 2157 CZ3 TRP A 274 -8.892 1.487 -5.963 1.00 95.07 C \\\\nATOM 2158 N CYS A 275 -11.102 -0.468 -9.505 1.00 97.41 N \\\\nATOM 2159 CA CYS A 275 -9.862 -0.335 -10.263 1.00 97.41 C \\\\nATOM 2160 C CYS A 275 -9.446 -1.606 -11.010 1.00 97.41 C \\\\nATOM 2161 CB CYS A 275 -8.727 0.177 -9.357 1.00 97.41 C \\\\nATOM 2162 O CYS A 275 -9.892 -2.718 -10.710 1.00 97.41 O \\\\nATOM 2163 SG CYS A 275 -8.172 -1.078 -8.170 1.00 97.41 S \\\\nATOM 2164 N SER A 276 -8.544 -1.421 -11.972 1.00 97.86 N \\\\nATOM 2165 CA SER A 276 -7.793 -2.494 -12.626 1.00 97.86 C \\\\nATOM 2166 C SER A 276 -6.289 -2.268 -12.470 1.00 97.86 C \\\\nATOM 2167 CB SER A 276 -8.208 -2.627 -14.092 1.00 97.86 C \\\\nATOM 2168 O SER A 276 -5.836 -1.124 -12.540 1.00 97.86 O \\\\nATOM 2169 OG SER A 276 -7.734 -1.550 -14.869 1.00 97.86 O \\\\nATOM 2170 N ILE A 277 -5.524 -3.339 -12.253 1.00 98.47 N \\\\nATOM 2171 CA ILE A 277 -4.088 -3.291 -11.952 1.00 98.47 C \\\\nATOM 2172 C ILE A 277 -3.315 -4.126 -12.969 1.00 98.47 C \\\\nATOM 2173 CB ILE A 277 -3.763 -3.772 -10.515 1.00 98.47 C \\\\nATOM 2174 O ILE A 277 -3.540 -5.331 -13.081 1.00 98.47 O \\\\nATOM 2175 CG1 ILE A 277 -4.882 -3.422 -9.506 1.00 98.47 C \\\\nATOM 2176 CG2 ILE A 277 -2.366 -3.251 -10.127 1.00 98.47 C \\\\nATOM 2177 CD1 ILE A 277 -4.496 -3.473 -8.027 1.00 98.47 C \\\\nATOM 2178 N ALA A 278 -2.370 -3.509 -13.673 1.00 98.55 N \\\\nATOM 2179 CA ALA A 278 -1.424 -4.200 -14.544 1.00 98.55 C \\\\nATOM 2180 C ALA A 278 -0.030 -4.218 -13.905 1.00 98.55 C \\\\nATOM 2181 CB ALA A 278 -1.436 -3.533 -15.922 1.00 98.55 C \\\\nATOM 2182 O ALA A 278 0.429 -3.200 -13.390 1.00 98.55 O \\\\nATOM 2183 N TYR A 279 0.645 -5.369 -13.934 1.00 98.63 N \\\\nATOM 2184 CA TYR A 279 2.011 -5.519 -13.431 1.00 98.63 C \\\\nATOM 2185 C TYR A 279 3.033 -5.476 -14.565 1.00 98.63 C \\\\nATOM 2186 CB TYR A 279 2.130 -6.801 -12.598 1.00 98.63 C \\\\nATOM 2187 O TYR A 279 2.824 -6.041 -15.641 1.00 98.63 O \\\\nATOM 2188 CG TYR A 279 3.542 -7.114 -12.125 1.00 98.63 C \\\\nATOM 2189 CD1 TYR A 279 4.171 -8.309 -12.518 1.00 98.63 C \\\\nATOM 2190 CD2 TYR A 279 4.229 -6.208 -11.296 1.00 98.63 C \\\\nATOM 2191 CE1 TYR A 279 5.469 -8.611 -12.068 1.00 98.63 C \\\\nATOM 2192 CE2 TYR A 279 5.536 -6.493 -10.858 1.00 98.63 C \\\\nATOM 2193 OH TYR A 279 7.386 -8.020 -10.749 1.00 98.63 O \\\\nATOM 2194 CZ TYR A 279 6.152 -7.707 -11.229 1.00 98.63 C \\\\nATOM 2195 N TYR A 280 4.157 -4.820 -14.295 1.00 98.73 N \\\\nATOM 2196 CA TYR A 280 5.253 -4.645 -15.227 1.00 98.73 C \\\\nATOM 2197 C TYR A 280 6.598 -4.950 -14.563 1.00 98.73 C \\\\nATOM 2198 CB TYR A 280 5.235 -3.217 -15.775 1.00 98.73 C \\\\nATOM 2199 O TYR A 280 6.865 -4.613 -13.403 1.00 98.73 O \\\\nATOM 2200 CG TYR A 280 4.056 -2.864 -16.663 1.00 98.73 C \\\\nATOM 2201 CD1 TYR A 280 4.181 -2.933 -18.064 1.00 98.73 C \\\\nATOM 2202 CD2 TYR A 280 2.855 -2.401 -16.090 1.00 98.73 C \\\\nATOM 2203 CE1 TYR A 280 3.098 -2.569 -18.890 1.00 98.73 C \\\\nATOM 2204 CE2 TYR A 280 1.780 -2.014 -16.913 1.00 98.73 C \\\\nATOM 2205 OH TYR A 280 0.868 -1.716 -19.113 1.00 98.73 O \\\\nATOM 2206 CZ TYR A 280 1.896 -2.105 -18.315 1.00 98.73 C \\\\nATOM 2207 N GLU A 281 7.479 -5.555 -15.351 1.00 98.51 N \\\\nATOM 2208 CA GLU A 281 8.898 -5.694 -15.056 1.00 98.51 C \\\\nATOM 2209 C GLU A 281 9.661 -4.903 -16.118 1.00 98.51 C \\\\nATOM 2210 CB GLU A 281 9.305 -7.179 -15.015 1.00 98.51 C \\\\nATOM 2211 O GLU A 281 9.632 -5.253 -17.297 1.00 98.51 O \\\\nATOM 2212 CG GLU A 281 8.652 -7.916 -13.832 1.00 98.51 C \\\\nATOM 2213 CD GLU A 281 8.992 -9.413 -13.731 1.00 98.51 C \\\\nATOM 2214 OE1 GLU A 281 8.462 -10.094 -12.822 1.00 98.51 O \\\\nATOM 2215 OE2 GLU A 281 9.816 -9.955 -14.502 1.00 98.51 O \\\\nATOM 2216 N LEU A 282 10.322 -3.812 -15.716 1.00 97.97 N \\\\nATOM 2217 CA LEU A 282 10.910 -2.843 -16.646 1.00 97.97 C \\\\nATOM 2218 C LEU A 282 9.847 -2.264 -17.600 1.00 97.97 C \\\\nATOM 2219 CB LEU A 282 12.144 -3.445 -17.358 1.00 97.97 C \\\\nATOM 2220 O LEU A 282 8.870 -1.684 -17.146 1.00 97.97 O \\\\nATOM 2221 CG LEU A 282 13.223 -3.999 -16.419 1.00 97.97 C \\\\nATOM 2222 CD1 LEU A 282 14.239 -4.800 -17.230 1.00 97.97 C \\\\nATOM 2223 CD2 LEU A 282 13.966 -2.879 -15.685 1.00 97.97 C \\\\nATOM 2224 N ASN A 283 10.004 -2.398 -18.913 1.00 97.02 N \\\\nATOM 2225 CA ASN A 283 9.026 -1.967 -19.914 1.00 97.02 C \\\\nATOM 2226 C ASN A 283 8.091 -3.098 -20.380 1.00 97.02 C \\\\nATOM 2227 CB ASN A 283 9.777 -1.319 -21.090 1.00 97.02 C \\\\nATOM 2228 O ASN A 283 7.291 -2.881 -21.287 1.00 97.02 O \\\\nATOM 2229 CG ASN A 283 10.673 -2.289 -21.843 1.00 97.02 C \\\\nATOM 2230 ND2 ASN A 283 10.969 -2.008 -23.087 1.00 97.02 N \\\\nATOM 2231 OD1 ASN A 283 11.151 -3.283 -21.320 1.00 97.02 O \\\\nATOM 2232 N GLN A 284 8.187 -4.297 -19.798 1.00 97.84 N \\\\nATOM 2233 CA GLN A 284 7.410 -5.460 -20.216 1.00 97.84 C \\\\nATOM 2234 C GLN A 284 6.244 -5.708 -19.260 1.00 97.84 C \\\\nATOM 2235 CB GLN A 284 8.342 -6.674 -20.321 1.00 97.84 C \\\\nATOM 2236 O GLN A 284 6.435 -5.811 -18.048 1.00 97.84 O \\\\nATOM 2237 CG GLN A 284 7.625 -7.885 -20.934 1.00 97.84 C \\\\nATOM 2238 CD GLN A 284 8.527 -9.101 -21.097 1.00 97.84 C \\\\nATOM 2239 NE2 GLN A 284 8.044 -10.153 -21.718 1.00 97.84 N \\\\nATOM 2240 OE1 GLN A 284 9.677 -9.143 -20.691 1.00 97.84 O \\\\nATOM 2241 N ARG A 285 5.033 -5.853 -19.806 1.00 98.04 N \\\\nATOM 2242 CA ARG A 285 3.860 -6.294 -19.041 1.00 98.04 C \\\\nATOM 2243 C ARG A 285 3.996 -7.771 -18.681 1.00 98.04 C \\\\nATOM 2244 CB ARG A 285 2.586 -6.010 -19.841 1.00 98.04 C \\\\nATOM 2245 O ARG A 285 4.353 -8.586 -19.531 1.00 98.04 O \\\\nATOM 2246 CG ARG A 285 1.316 -6.279 -19.020 1.00 98.04 C \\\\nATOM 2247 CD ARG A 285 0.115 -5.771 -19.815 1.00 98.04 C \\\\nATOM 2248 NE ARG A 285 -1.167 -6.187 -19.224 1.00 98.04 N \\\\nATOM 2249 NH1 ARG A 285 -2.464 -5.493 -20.990 1.00 98.04 N \\\\nATOM 2250 NH2 ARG A 285 -3.411 -6.566 -19.315 1.00 98.04 N \\\\nATOM 2251 CZ ARG A 285 -2.332 -6.079 -19.834 1.00 98.04 C \\\\nATOM 2252 N VAL A 286 3.700 -8.113 -17.432 1.00 98.24 N \\\\nATOM 2253 CA VAL A 286 3.852 -9.466 -16.892 1.00 98.24 C \\\\nATOM 2254 C VAL A 286 2.558 -9.890 -16.201 1.00 98.24 C \\\\nATOM 2255 CB VAL A 286 5.064 -9.534 -15.940 1.00 98.24 C \\\\nATOM 2256 O VAL A 286 2.137 -9.270 -15.229 1.00 98.24 O \\\\nATOM 2257 CG1 VAL A 286 5.211 -10.922 -15.307 1.00 98.24 C \\\\nATOM 2258 CG2 VAL A 286 6.374 -9.224 -16.675 1.00 98.24 C \\\\nATOM 2259 N GLY A 287 1.964 -10.987 -16.673 1.00 96.53 N \\\\nATOM 2260 CA GLY A 287 0.712 -11.524 -16.137 1.00 96.53 C \\\\nATOM 2261 C GLY A 287 -0.550 -10.832 -16.658 1.00 96.53 C \\\\nATOM 2262 O GLY A 287 -0.506 -9.941 -17.509 1.00 96.53 O \\\\nATOM 2263 N GLU A 288 -1.691 -11.282 -16.143 1.00 95.82 N \\\\nATOM 2264 CA GLU A 288 -3.015 -10.746 -16.466 1.00 95.82 C \\\\nATOM 2265 C GLU A 288 -3.318 -9.466 -15.673 1.00 95.82 C \\\\nATOM 2266 CB GLU A 288 -4.087 -11.816 -16.208 1.00 95.82 C \\\\nATOM 2267 O GLU A 288 -2.705 -9.190 -14.639 1.00 95.82 O \\\\nATOM 2268 CG GLU A 288 -3.880 -13.061 -17.087 1.00 95.82 C \\\\nATOM 2269 CD GLU A 288 -4.966 -14.124 -16.878 1.00 95.82 C \\\\nATOM 2270 OE1 GLU A 288 -5.203 -14.883 -17.841 1.00 95.82 O \\\\nATOM 2271 OE2 GLU A 288 -5.517 -14.185 -15.757 1.00 95.82 O \\\\nATOM 2272 N THR A 289 -4.281 -8.673 -16.151 1.00 97.10 N \\\\nATOM 2273 CA THR A 289 -4.793 -7.538 -15.371 1.00 97.10 C \\\\nATOM 2274 C THR A 289 -5.664 -8.040 -14.233 1.00 97.10 C \\\\nATOM 2275 CB THR A 289 -5.594 -6.550 -16.222 1.00 97.10 C \\\\nATOM 2276 O THR A 289 -6.643 -8.753 -14.450 1.00 97.10 O \\\\nATOM 2277 CG2 THR A 289 -6.231 -5.405 -15.443 1.00 97.10 C \\\\nATOM 2278 OG1 THR A 289 -4.718 -5.889 -17.089 1.00 97.10 O \\\\nATOM 2279 N PHE A 290 -5.354 -7.596 -13.022 1.00 96.97 N \\\\nATOM 2280 CA PHE A 290 -6.176 -7.846 -11.851 1.00 96.97 C \\\\nATOM 2281 C PHE A 290 -7.320 -6.830 -11.776 1.00 96.97 C \\\\nATOM 2282 CB PHE A 290 -5.278 -7.792 -10.620 1.00 96.97 C \\\\nATOM 2283 O PHE A 290 -7.086 -5.631 -11.914 1.00 96.97 O \\\\nATOM 2284 CG PHE A 290 -5.994 -8.160 -9.344 1.00 96.97 C \\\\nATOM 2285 CD1 PHE A 290 -6.638 -7.167 -8.583 1.00 96.97 C \\\\nATOM 2286 CD2 PHE A 290 -6.019 -9.502 -8.923 1.00 96.97 C \\\\nATOM 2287 CE1 PHE A 290 -7.286 -7.513 -7.387 1.00 96.97 C \\\\nATOM 2288 CE2 PHE A 290 -6.657 -9.847 -7.721 1.00 96.97 C \\\\nATOM 2289 CZ PHE A 290 -7.279 -8.850 -6.953 1.00 96.97 C \\\\nATOM 2290 N HIS A 291 -8.545 -7.287 -11.519 1.00 96.94 N \\\\nATOM 2291 CA HIS A 291 -9.725 -6.426 -11.405 1.00 96.94 C \\\\nATOM 2292 C HIS A 291 -10.249 -6.449 -9.969 1.00 96.94 C \\\\nATOM 2293 CB HIS A 291 -10.791 -6.861 -12.416 1.00 96.94 C \\\\nATOM 2294 O HIS A 291 -10.591 -7.504 -9.439 1.00 96.94 O \\\\nATOM 2295 CG HIS A 291 -10.338 -6.727 -13.848 1.00 96.94 C \\\\nATOM 2296 CD2 HIS A 291 -10.580 -5.670 -14.683 1.00 96.94 C \\\\nATOM 2297 ND1 HIS A 291 -9.591 -7.641 -14.559 1.00 96.94 N \\\\nATOM 2298 CE1 HIS A 291 -9.403 -7.152 -15.793 1.00 96.94 C \\\\nATOM 2299 NE2 HIS A 291 -9.971 -5.943 -15.910 1.00 96.94 N \\\\nATOM 2300 N ALA A 292 -10.304 -5.281 -9.332 1.00 94.85 N \\\\nATOM 2301 CA ALA A 292 -10.612 -5.160 -7.915 1.00 94.85 C \\\\nATOM 2302 C ALA A 292 -12.092 -4.856 -7.678 1.00 94.85 C \\\\nATOM 2303 CB ALA A 292 -9.737 -4.054 -7.345 1.00 94.85 C \\\\nATOM 2304 O ALA A 292 -12.557 -3.755 -7.970 1.00 94.85 O \\\\nATOM 2305 N SER A 293 -12.831 -5.824 -7.138 1.00 91.03 N \\\\nATOM 2306 CA SER A 293 -14.233 -5.637 -6.736 1.00 91.03 C \\\\nATOM 2307 C SER A 293 -14.364 -5.249 -5.264 1.00 91.03 C \\\\nATOM 2308 CB SER A 293 -15.029 -6.910 -7.021 1.00 91.03 C \\\\nATOM 2309 O SER A 293 -15.207 -4.432 -4.909 1.00 91.03 O \\\\nATOM 2310 OG SER A 293 -14.425 -8.035 -6.398 1.00 91.03 O \\\\nATOM 2311 N GLN A 294 -13.508 -5.801 -4.401 1.00 90.62 N \\\\nATOM 2312 CA GLN A 294 -13.521 -5.508 -2.970 1.00 90.62 C \\\\nATOM 2313 C GLN A 294 -12.933 -4.120 -2.681 1.00 90.62 C \\\\nATOM 2314 CB GLN A 294 -12.771 -6.602 -2.189 1.00 90.62 C \\\\nATOM 2315 O GLN A 294 -11.941 -3.742 -3.312 1.00 90.62 O \\\\nATOM 2316 CG GLN A 294 -13.435 -7.982 -2.320 1.00 90.62 C \\\\nATOM 2317 CD GLN A 294 -14.891 -7.991 -1.863 1.00 90.62 C \\\\nATOM 2318 NE2 GLN A 294 -15.742 -8.766 -2.496 1.00 90.62 N \\\\nATOM 2319 OE1 GLN A 294 -15.304 -7.279 -0.963 1.00 90.62 O \\\\nATOM 2320 N PRO A 295 -13.460 -3.378 -1.687 1.00 89.93 N \\\\nATOM 2321 CA PRO A 295 -12.981 -2.036 -1.345 1.00 89.93 C \\\\nATOM 2322 C PRO A 295 -11.551 -2.033 -0.797 1.00 89.93 C \\\\nATOM 2323 CB PRO A 295 -13.969 -1.515 -0.295 1.00 89.93 C \\\\nATOM 2324 O PRO A 295 -10.946 -0.978 -0.670 1.00 89.93 O \\\\nATOM 2325 CG PRO A 295 -14.477 -2.789 0.379 1.00 89.93 C \\\\nATOM 2326 CD PRO A 295 -14.529 -3.779 -0.780 1.00 89.93 C \\\\nATOM 2327 N SER A 296 -10.995 -3.195 -0.456 1.00 92.89 N \\\\nATOM 2328 CA SER A 296 -9.617 -3.358 -0.006 1.00 92.89 C \\\\nATOM 2329 C SER A 296 -8.981 -4.532 -0.741 1.00 92.89 C \\\\nATOM 2330 CB SER A 296 -9.600 -3.576 1.509 1.00 92.89 C \\\\nATOM 2331 O SER A 296 -9.544 -5.622 -0.763 1.00 92.89 O \\\\nATOM 2332 OG SER A 296 -8.313 -3.961 1.962 1.00 92.89 O \\\\nATOM 2333 N LEU A 297 -7.772 -4.335 -1.261 1.00 96.06 N \\\\nATOM 2334 CA LEU A 297 -6.951 -5.391 -1.853 1.00 96.06 C \\\\nATOM 2335 C LEU A 297 -5.479 -5.222 -1.463 1.00 96.06 C \\\\nATOM 2336 CB LEU A 297 -7.161 -5.421 -3.378 1.00 96.06 C \\\\nATOM 2337 O LEU A 297 -5.037 -4.141 -1.076 1.00 96.06 O \\\\nATOM 2338 CG LEU A 297 -6.436 -4.267 -4.101 1.00 96.06 C \\\\nATOM 2339 CD1 LEU A 297 -5.200 -4.773 -4.846 1.00 96.06 C \\\\nATOM 2340 CD2 LEU A 297 -7.335 -3.596 -5.117 1.00 96.06 C \\\\nATOM 2341 N THR A 298 -4.699 -6.290 -1.571 1.00 97.78 N \\\\nATOM 2342 CA THR A 298 -3.249 -6.266 -1.349 1.00 97.78 C \\\\nATOM 2343 C THR A 298 -2.525 -6.752 -2.597 1.00 97.78 C \\\\nATOM 2344 CB THR A 298 -2.871 -7.103 -0.118 1.00 97.78 C \\\\nATOM 2345 O THR A 298 -2.809 -7.838 -3.088 1.00 97.78 O \\\\nATOM 2346 CG2 THR A 298 -1.411 -6.913 0.276 1.00 97.78 C \\\\nATOM 2347 OG1 THR A 298 -3.663 -6.707 0.989 1.00 97.78 O \\\\nATOM 2348 N VAL A 299 -1.578 -5.969 -3.109 1.00 98.41 N \\\\nATOM 2349 CA VAL A 299 -0.645 -6.407 -4.154 1.00 98.41 C \\\\nATOM 2350 C VAL A 299 0.644 -6.826 -3.462 1.00 98.41 C \\\\nATOM 2351 CB VAL A 299 -0.384 -5.311 -5.202 1.00 98.41 C \\\\nATOM 2352 O VAL A 299 1.325 -5.978 -2.886 1.00 98.41 O \\\\nATOM 2353 CG1 VAL A 299 0.448 -5.885 -6.351 1.00 98.41 C \\\\nATOM 2354 CG2 VAL A 299 -1.672 -4.700 -5.766 1.00 98.41 C \\\\nATOM 2355 N ASP A 300 0.964 -8.118 -3.477 1.00 98.33 N \\\\nATOM 2356 CA ASP A 300 2.064 -8.694 -2.697 1.00 98.33 C \\\\nATOM 2357 C ASP A 300 2.994 -9.587 -3.532 1.00 98.33 C \\\\nATOM 2358 CB ASP A 300 1.516 -9.372 -1.427 1.00 98.33 C \\\\nATOM 2359 O ASP A 300 2.729 -9.896 -4.690 1.00 98.33 O \\\\nATOM 2360 CG ASP A 300 0.725 -10.659 -1.648 1.00 98.33 C \\\\nATOM 2361 OD1 ASP A 300 1.220 -11.561 -2.354 1.00 98.33 O \\\\nATOM 2362 OD2 ASP A 300 -0.292 -10.861 -0.942 1.00 98.33 O \\\\nATOM 2363 N GLY A 301 4.136 -9.963 -2.957 1.00 97.82 N \\\\nATOM 2364 CA GLY A 301 5.156 -10.794 -3.602 1.00 97.82 C \\\\nATOM 2365 C GLY A 301 4.979 -12.297 -3.375 1.00 97.82 C \\\\nATOM 2366 O GLY A 301 5.909 -13.049 -3.660 1.00 97.82 O \\\\nATOM 2367 N PHE A 302 3.843 -12.743 -2.830 1.00 97.35 N \\\\nATOM 2368 CA PHE A 302 3.573 -14.155 -2.546 1.00 97.35 C \\\\nATOM 2369 C PHE A 302 2.885 -14.841 -3.740 1.00 97.35 C \\\\nATOM 2370 CB PHE A 302 2.783 -14.263 -1.232 1.00 97.35 C \\\\nATOM 2371 O PHE A 302 2.907 -14.325 -4.856 1.00 97.35 O \\\\nATOM 2372 CG PHE A 302 3.435 -13.594 -0.030 1.00 97.35 C \\\\nATOM 2373 CD1 PHE A 302 4.690 -14.039 0.428 1.00 97.35 C \\\\nATOM 2374 CD2 PHE A 302 2.791 -12.539 0.644 1.00 97.35 C \\\\nATOM 2375 CE1 PHE A 302 5.291 -13.437 1.547 1.00 97.35 C \\\\nATOM 2376 CE2 PHE A 302 3.385 -11.946 1.771 1.00 97.35 C \\\\nATOM 2377 CZ PHE A 302 4.638 -12.392 2.223 1.00 97.35 C \\\\nATOM 2378 N THR A 303 2.335 -16.044 -3.546 1.00 96.72 N \\\\nATOM 2379 CA THR A 303 1.984 -16.964 -4.647 1.00 96.72 C \\\\nATOM 2380 C THR A 303 0.567 -17.547 -4.562 1.00 96.72 C \\\\nATOM 2381 CB THR A 303 3.019 -18.101 -4.740 1.00 96.72 C \\\\nATOM 2382 O THR A 303 0.355 -18.666 -5.015 1.00 96.72 O \\\\nATOM 2383 CG2 THR A 303 4.447 -17.610 -4.978 1.00 96.72 C \\\\nATOM 2384 OG1 THR A 303 3.013 -18.832 -3.534 1.00 96.72 O \\\\nATOM 2385 N ASP A 304 -0.398 -16.851 -3.956 1.00 94.15 N \\\\nATOM 2386 CA ASP A 304 -1.798 -17.309 -3.915 1.00 94.15 C \\\\nATOM 2387 C ASP A 304 -2.532 -16.889 -5.205 1.00 94.15 C \\\\nATOM 2388 CB ASP A 304 -2.473 -16.747 -2.658 1.00 94.15 C \\\\nATOM 2389 O ASP A 304 -2.710 -15.693 -5.423 1.00 94.15 O \\\\nATOM 2390 CG ASP A 304 -3.936 -17.159 -2.451 1.00 94.15 C \\\\nATOM 2391 OD1 ASP A 304 -4.527 -17.856 -3.318 1.00 94.15 O \\\\nATOM 2392 OD2 ASP A 304 -4.436 -16.746 -1.375 1.00 94.15 O \\\\nATOM 2393 N PRO A 305 -2.946 -17.827 -6.077 1.00 91.29 N \\\\nATOM 2394 CA PRO A 305 -3.564 -17.491 -7.360 1.00 91.29 C \\\\nATOM 2395 C PRO A 305 -5.070 -17.204 -7.267 1.00 91.29 C \\\\nATOM 2396 CB PRO A 305 -3.296 -18.721 -8.232 1.00 91.29 C \\\\nATOM 2397 O PRO A 305 -5.663 -16.781 -8.252 1.00 91.29 O \\\\nATOM 2398 CG PRO A 305 -3.376 -19.872 -7.230 1.00 91.29 C \\\\nATOM 2399 CD PRO A 305 -2.768 -19.270 -5.965 1.00 91.29 C \\\\nATOM 2400 N SER A 306 -5.711 -17.495 -6.131 1.00 88.57 N \\\\nATOM 2401 CA SER A 306 -7.172 -17.684 -6.059 1.00 88.57 C \\\\nATOM 2402 C SER A 306 -7.919 -16.630 -5.244 1.00 88.57 C \\\\nATOM 2403 CB SER A 306 -7.461 -19.087 -5.524 1.00 88.57 C \\\\nATOM 2404 O SER A 306 -9.147 -16.650 -5.163 1.00 88.57 O \\\\nATOM 2405 OG SER A 306 -6.983 -19.271 -4.198 1.00 88.57 O \\\\nATOM 2406 N ASN A 307 -7.193 -15.712 -4.614 1.00 87.96 N \\\\nATOM 2407 CA ASN A 307 -7.768 -14.765 -3.675 1.00 87.96 C \\\\nATOM 2408 C ASN A 307 -8.130 -13.440 -4.363 1.00 87.96 C \\\\nATOM 2409 CB ASN A 307 -6.780 -14.647 -2.514 1.00 87.96 C \\\\nATOM 2410 O ASN A 307 -7.258 -12.690 -4.791 1.00 87.96 O \\\\nATOM 2411 CG ASN A 307 -7.307 -13.822 -1.365 1.00 87.96 C \\\\nATOM 2412 ND2 ASN A 307 -6.954 -14.183 -0.156 1.00 87.96 N \\\\nATOM 2413 OD1 ASN A 307 -8.048 -12.869 -1.514 1.00 87.96 O \\\\nATOM 2414 N SER A 308 -9.423 -13.110 -4.406 1.00 89.03 N \\\\nATOM 2415 CA SER A 308 -9.940 -11.878 -5.023 1.00 89.03 C \\\\nATOM 2416 C SER A 308 -9.550 -10.582 -4.298 1.00 89.03 C \\\\nATOM 2417 CB SER A 308 -11.465 -11.960 -5.118 1.00 89.03 C \\\\nATOM 2418 O SER A 308 -9.783 -9.498 -4.821 1.00 89.03 O \\\\nATOM 2419 OG SER A 308 -12.037 -12.143 -3.834 1.00 89.03 O \\\\nATOM 2420 N GLU A 309 -8.983 -10.665 -3.094 1.00 92.14 N \\\\nATOM 2421 CA GLU A 309 -8.434 -9.529 -2.341 1.00 92.14 C \\\\nATOM 2422 C GLU A 309 -6.903 -9.457 -2.441 1.00 92.14 C \\\\nATOM 2423 CB GLU A 309 -8.846 -9.615 -0.863 1.00 92.14 C \\\\nATOM 2424 O GLU A 309 -6.290 -8.568 -1.843 1.00 92.14 O \\\\nATOM 2425 CG GLU A 309 -10.360 -9.535 -0.631 1.00 92.14 C \\\\nATOM 2426 CD GLU A 309 -10.740 -9.691 0.853 1.00 92.14 C \\\\nATOM 2427 OE1 GLU A 309 -11.953 -9.833 1.122 1.00 92.14 O \\\\nATOM 2428 OE2 GLU A 309 -9.837 -9.684 1.728 1.00 92.14 O \\\\nATOM 2429 N ARG A 310 -6.252 -10.390 -3.154 1.00 96.04 N \\\\nATOM 2430 CA ARG A 310 -4.791 -10.445 -3.258 1.00 96.04 C \\\\nATOM 2431 C ARG A 310 -4.327 -10.595 -4.697 1.00 96.04 C \\\\nATOM 2432 CB ARG A 310 -4.203 -11.564 -2.396 1.00 96.04 C \\\\nATOM 2433 O ARG A 310 -4.538 -11.619 -5.333 1.00 96.04 O \\\\nATOM 2434 CG ARG A 310 -4.527 -11.394 -0.906 1.00 96.04 C \\\\nATOM 2435 CD ARG A 310 -3.942 -12.550 -0.098 1.00 96.04 C \\\\nATOM 2436 NE ARG A 310 -2.472 -12.565 -0.148 1.00 96.04 N \\\\nATOM 2437 NH1 ARG A 310 -2.160 -14.826 0.181 1.00 96.04 N \\\\nATOM 2438 NH2 ARG A 310 -0.422 -13.452 -0.107 1.00 96.04 N \\\\nATOM 2439 CZ ARG A 310 -1.701 -13.620 -0.017 1.00 96.04 C \\\\nATOM 2440 N PHE A 311 -3.589 -9.599 -5.170 1.00 97.27 N \\\\nATOM 2441 CA PHE A 311 -2.848 -9.704 -6.414 1.00 97.27 C \\\\nATOM 2442 C PHE A 311 -1.417 -10.164 -6.116 1.00 97.27 C \\\\nATOM 2443 CB PHE A 311 -2.922 -8.385 -7.183 1.00 97.27 C \\\\nATOM 2444 O PHE A 311 -0.531 -9.370 -5.791 1.00 97.27 O \\\\nATOM 2445 CG PHE A 311 -2.310 -8.407 -8.574 1.00 97.27 C \\\\nATOM 2446 CD1 PHE A 311 -1.940 -7.188 -9.172 1.00 97.27 C \\\\nATOM 2447 CD2 PHE A 311 -2.148 -9.609 -9.300 1.00 97.27 C \\\\nATOM 2448 CE1 PHE A 311 -1.416 -7.167 -10.476 1.00 97.27 C \\\\nATOM 2449 CE2 PHE A 311 -1.618 -9.587 -10.599 1.00 97.27 C \\\\nATOM 2450 CZ PHE A 311 -1.255 -8.367 -11.190 1.00 97.27 C \\\\nATOM 2451 N CYS A 312 -1.209 -11.476 -6.173 1.00 97.36 N \\\\nATOM 2452 CA CYS A 312 0.056 -12.118 -5.839 1.00 97.36 C \\\\nATOM 2453 C CYS A 312 1.023 -12.116 -7.031 1.00 97.36 C \\\\nATOM 2454 CB CYS A 312 -0.262 -13.530 -5.345 1.00 97.36 C \\\\nATOM 2455 O CYS A 312 0.951 -12.957 -7.924 1.00 97.36 O \\\\nATOM 2456 SG CYS A 312 -0.905 -13.448 -3.650 1.00 97.36 S \\\\nATOM 2457 N LEU A 313 1.981 -11.193 -7.027 1.00 97.92 N \\\\nATOM 2458 CA LEU A 313 2.961 -11.027 -8.100 1.00 97.92 C \\\\nATOM 2459 C LEU A 313 3.986 -12.164 -8.147 1.00 97.92 C \\\\nATOM 2460 CB LEU A 313 3.682 -9.679 -7.923 1.00 97.92 C \\\\nATOM 2461 O LEU A 313 4.587 -12.400 -9.197 1.00 97.92 O \\\\nATOM 2462 CG LEU A 313 2.757 -8.448 -7.849 1.00 97.92 C \\\\nATOM 2463 CD1 LEU A 313 3.620 -7.194 -7.709 1.00 97.92 C \\\\nATOM 2464 CD2 LEU A 313 1.873 -8.320 -9.087 1.00 97.92 C \\\\nATOM 2465 N GLY A 314 4.205 -12.865 -7.030 1.00 97.10 N \\\\nATOM 2466 CA GLY A 314 5.233 -13.897 -6.866 1.00 97.10 C \\\\nATOM 2467 C GLY A 314 5.062 -15.102 -7.791 1.00 97.10 C \\\\nATOM 2468 O GLY A 314 6.067 -15.654 -8.237 1.00 97.10 O \\\\nATOM 2469 N LEU A 315 3.819 -15.453 -8.143 1.00 95.97 N \\\\nATOM 2470 CA LEU A 315 3.499 -16.566 -9.051 1.00 95.97 C \\\\nATOM 2471 C LEU A 315 3.662 -16.217 -10.539 1.00 95.97 C \\\\nATOM 2472 CB LEU A 315 2.086 -17.092 -8.729 1.00 95.97 C \\\\nATOM 2473 O LEU A 315 3.755 -17.111 -11.380 1.00 95.97 O \\\\nATOM 2474 CG LEU A 315 0.935 -16.120 -9.073 1.00 95.97 C \\\\nATOM 2475 CD1 LEU A 315 0.299 -16.433 -10.426 1.00 95.97 C \\\\nATOM 2476 CD2 LEU A 315 -0.157 -16.195 -8.008 1.00 95.97 C \\\\nATOM 2477 N LEU A 316 3.706 -14.925 -10.878 1.00 96.99 N \\\\nATOM 2478 CA LEU A 316 3.794 -14.481 -12.265 1.00 96.99 C \\\\nATOM 2479 C LEU A 316 5.173 -14.805 -12.842 1.00 96.99 C \\\\nATOM 2480 CB LEU A 316 3.471 -12.984 -12.385 1.00 96.99 C \\\\nATOM 2481 O LEU A 316 6.210 -14.418 -12.291 1.00 96.99 O \\\\nATOM 2482 CG LEU A 316 2.113 -12.561 -11.798 1.00 96.99 C \\\\nATOM 2483 CD1 LEU A 316 1.944 -11.053 -11.957 1.00 96.99 C \\\\nATOM 2484 CD2 LEU A 316 0.944 -13.261 -12.490 1.00 96.99 C \\\\nATOM 2485 N SER A 317 5.184 -15.500 -13.972 1.00 96.68 N \\\\nATOM 2486 CA SER A 317 6.404 -15.879 -14.683 1.00 96.68 C \\\\nATOM 2487 C SER A 317 6.768 -14.847 -15.747 1.00 96.68 C \\\\nATOM 2488 CB SER A 317 6.244 -17.279 -15.274 1.00 96.68 C \\\\nATOM 2489 O SER A 317 5.897 -14.247 -16.368 1.00 96.68 O \\\\nATOM 2490 OG SER A 317 6.150 -18.211 -14.215 1.00 96.68 O \\\\nATOM 2491 N ASN A 318 8.068 -14.645 -15.957 1.00 96.83 N \\\\nATOM 2492 CA ASN A 318 8.603 -13.826 -17.038 1.00 96.83 C \\\\nATOM 2493 C ASN A 318 9.930 -14.436 -17.500 1.00 96.83 C \\\\nATOM 2494 CB ASN A 318 8.779 -12.374 -16.559 1.00 96.83 C \\\\nATOM 2495 O ASN A 318 10.871 -14.531 -16.712 1.00 96.83 O \\\\nATOM 2496 CG ASN A 318 9.386 -11.484 -17.632 1.00 96.83 C \\\\nATOM 2497 ND2 ASN A 318 9.829 -10.306 -17.276 1.00 96.83 N \\\\nATOM 2498 OD1 ASN A 318 9.485 -11.850 -18.793 1.00 96.83 O \\\\nATOM 2499 N VAL A 319 10.000 -14.848 -18.766 1.00 97.17 N \\\\nATOM 2500 CA VAL A 319 11.196 -15.471 -19.359 1.00 97.17 C \\\\nATOM 2501 C VAL A 319 12.351 -14.482 -19.547 1.00 97.17 C \\\\nATOM 2502 CB VAL A 319 10.863 -16.166 -20.694 1.00 97.17 C \\\\nATOM 2503 O VAL A 319 13.506 -14.891 -19.538 1.00 97.17 O \\\\nATOM 2504 CG1 VAL A 319 9.882 -17.326 -20.475 1.00 97.17 C \\\\nATOM 2505 CG2 VAL A 319 10.269 -15.208 -21.737 1.00 97.17 C \\\\nATOM 2506 N ASN A 320 12.057 -13.181 -19.638 1.00 96.50 N \\\\nATOM 2507 CA ASN A 320 13.054 -12.117 -19.802 1.00 96.50 C \\\\nATOM 2508 C ASN A 320 13.523 -11.529 -18.459 1.00 96.50 C \\\\nATOM 2509 CB ASN A 320 12.464 -11.029 -20.705 1.00 96.50 C \\\\nATOM 2510 O ASN A 320 14.186 -10.488 -18.414 1.00 96.50 O \\\\nATOM 2511 CG ASN A 320 12.086 -11.526 -22.084 1.00 96.50 C \\\\nATOM 2512 ND2 ASN A 320 11.033 -10.985 -22.645 1.00 96.50 N \\\\nATOM 2513 OD1 ASN A 320 12.723 -12.384 -22.669 1.00 96.50 O \\\\nATOM 2514 N ARG A 321 13.147 -12.154 -17.338 1.00 97.58 N \\\\nATOM 2515 CA ARG A 321 13.455 -11.652 -16.001 1.00 97.58 C \\\\nATOM 2516 C ARG A 321 14.955 -11.720 -15.729 1.00 97.58 C \\\\nATOM 2517 CB ARG A 321 12.655 -12.456 -14.978 1.00 97.58 C \\\\nATOM 2518 O ARG A 321 15.547 -12.792 -15.714 1.00 97.58 O \\\\nATOM 2519 CG ARG A 321 12.835 -11.900 -13.562 1.00 97.58 C \\\\nATOM 2520 CD ARG A 321 11.934 -12.637 -12.575 1.00 97.58 C \\\\nATOM 2521 NE ARG A 321 10.512 -12.373 -12.857 1.00 97.58 N \\\\nATOM 2522 NH1 ARG A 321 9.606 -14.398 -12.205 1.00 97.58 N \\\\nATOM 2523 NH2 ARG A 321 8.307 -12.773 -12.966 1.00 97.58 N \\\\nATOM 2524 CZ ARG A 321 9.494 -13.189 -12.681 1.00 97.58 C \\\\nATOM 2525 N ASN A 322 15.557 -10.570 -15.437 1.00 97.73 N \\\\nATOM 2526 CA ASN A 322 16.963 -10.493 -15.040 1.00 97.73 C \\\\nATOM 2527 C ASN A 322 17.152 -10.588 -13.511 1.00 97.73 C \\\\nATOM 2528 CB ASN A 322 17.599 -9.249 -15.686 1.00 97.73 C \\\\nATOM 2529 O ASN A 322 16.209 -10.436 -12.729 1.00 97.73 O \\\\nATOM 2530 CG ASN A 322 17.151 -7.924 -15.094 1.00 97.73 C \\\\nATOM 2531 ND2 ASN A 322 16.987 -6.916 -15.913 1.00 97.73 N \\\\nATOM 2532 OD1 ASN A 322 16.995 -7.756 -13.892 1.00 97.73 O \\\\nATOM 2533 N ALA A 323 18.404 -10.758 -13.075 1.00 98.07 N \\\\nATOM 2534 CA ALA A 323 18.758 -10.909 -11.661 1.00 98.07 C \\\\nATOM 2535 C ALA A 323 18.328 -9.721 -10.772 1.00 98.07 C \\\\nATOM 2536 CB ALA A 323 20.276 -11.121 -11.582 1.00 98.07 C \\\\nATOM 2537 O ALA A 323 17.970 -9.910 -9.609 1.00 98.07 O \\\\nATOM 2538 N THR A 324 18.318 -8.489 -11.304 1.00 97.78 N \\\\nATOM 2539 CA THR A 324 17.886 -7.300 -10.543 1.00 97.78 C \\\\nATOM 2540 C THR A 324 16.382 -7.333 -10.272 1.00 97.78 C \\\\nATOM 2541 CB THR A 324 18.247 -5.996 -11.274 1.00 97.78 C \\\\nATOM 2542 O THR A 324 15.947 -7.012 -9.162 1.00 97.78 O \\\\nATOM 2543 CG2 THR A 324 17.804 -4.742 -10.517 1.00 97.78 C \\\\nATOM 2544 OG1 THR A 324 19.643 -5.883 -11.404 1.00 97.78 O \\\\nATOM 2545 N VAL A 325 15.585 -7.737 -11.264 1.00 98.29 N \\\\nATOM 2546 CA VAL A 325 14.136 -7.931 -11.116 1.00 98.29 C \\\\nATOM 2547 C VAL A 325 13.861 -9.056 -10.125 1.00 98.29 C \\\\nATOM 2548 CB VAL A 325 13.481 -8.218 -12.478 1.00 98.29 C \\\\nATOM 2549 O VAL A 325 13.096 -8.871 -9.184 1.00 98.29 O \\\\nATOM 2550 CG1 VAL A 325 11.986 -8.490 -12.319 1.00 98.29 C \\\\nATOM 2551 CG2 VAL A 325 13.630 -7.049 -13.462 1.00 98.29 C \\\\nATOM 2552 N GLU A 326 14.549 -10.189 -10.255 1.00 97.74 N \\\\nATOM 2553 CA GLU A 326 14.381 -11.326 -9.349 1.00 97.74 C \\\\nATOM 2554 C GLU A 326 14.725 -10.975 -7.890 1.00 97.74 C \\\\nATOM 2555 CB GLU A 326 15.262 -12.471 -9.852 1.00 97.74 C \\\\nATOM 2556 O GLU A 326 14.016 -11.359 -6.960 1.00 97.74 O \\\\nATOM 2557 CG GLU A 326 14.721 -13.828 -9.395 1.00 97.74 C \\\\nATOM 2558 CD GLU A 326 15.759 -14.933 -9.594 1.00 97.74 C \\\\nATOM 2559 OE1 GLU A 326 15.776 -15.832 -8.727 1.00 97.74 O \\\\nATOM 2560 OE2 GLU A 326 16.610 -14.789 -10.490 1.00 97.74 O \\\\nATOM 2561 N MET A 327 15.794 -10.209 -7.659 1.00 97.59 N \\\\nATOM 2562 CA MET A 327 16.147 -9.710 -6.327 1.00 97.59 C \\\\nATOM 2563 C MET A 327 15.103 -8.722 -5.792 1.00 97.59 C \\\\nATOM 2564 CB MET A 327 17.539 -9.070 -6.389 1.00 97.59 C \\\\nATOM 2565 O MET A 327 14.763 -8.762 -4.611 1.00 97.59 O \\\\nATOM 2566 CG MET A 327 18.035 -8.631 -5.006 1.00 97.59 C \\\\nATOM 2567 SD MET A 327 19.672 -7.856 -5.020 1.00 97.59 S \\\\nATOM 2568 CE MET A 327 20.725 -9.310 -5.290 1.00 97.59 C \\\\nATOM 2569 N THR A 328 14.567 -7.855 -6.653 1.00 98.24 N \\\\nATOM 2570 CA THR A 328 13.542 -6.872 -6.271 1.00 98.24 C \\\\nATOM 2571 C THR A 328 12.232 -7.556 -5.877 1.00 98.24 C \\\\nATOM 2572 CB THR A 328 13.318 -5.853 -7.398 1.00 98.24 C \\\\nATOM 2573 O THR A 328 11.670 -7.224 -4.836 1.00 98.24 O \\\\nATOM 2574 CG2 THR A 328 12.306 -4.781 -7.010 1.00 98.24 C \\\\nATOM 2575 OG1 THR A 328 14.542 -5.197 -7.673 1.00 98.24 O \\\\nATOM 2576 N ARG A 329 11.798 -8.577 -6.628 1.00 98.35 N \\\\nATOM 2577 CA ARG A 329 10.590 -9.370 -6.335 1.00 98.35 C \\\\nATOM 2578 C ARG A 329 10.609 -9.990 -4.937 1.00 98.35 C \\\\nATOM 2579 CB ARG A 329 10.412 -10.460 -7.402 1.00 98.35 C \\\\nATOM 2580 O ARG A 329 9.590 -9.963 -4.254 1.00 98.35 O \\\\nATOM 2581 CG ARG A 329 9.955 -9.872 -8.744 1.00 98.35 C \\\\nATOM 2582 CD ARG A 329 10.008 -10.903 -9.872 1.00 98.35 C \\\\nATOM 2583 NE ARG A 329 9.130 -12.058 -9.617 1.00 98.35 N \\\\nATOM 2584 NH1 ARG A 329 7.139 -11.118 -10.318 1.00 98.35 N \\\\nATOM 2585 NH2 ARG A 329 7.166 -13.166 -9.480 1.00 98.35 N \\\\nATOM 2586 CZ ARG A 329 7.825 -12.099 -9.806 1.00 98.35 C \\\\nATOM 2587 N ARG A 330 11.773 -10.465 -4.472 1.00 97.77 N \\\\nATOM 2588 CA ARG A 330 11.949 -11.017 -3.111 1.00 97.77 C \\\\nATOM 2589 C ARG A 330 11.653 -10.000 -2.003 1.00 97.77 C \\\\nATOM 2590 CB ARG A 330 13.377 -11.557 -2.929 1.00 97.77 C \\\\nATOM 2591 O ARG A 330 11.192 -10.388 -0.938 1.00 97.77 O \\\\nATOM 2592 CG ARG A 330 13.676 -12.800 -3.778 1.00 97.77 C \\\\nATOM 2593 CD ARG A 330 15.146 -13.199 -3.598 1.00 97.77 C \\\\nATOM 2594 NE ARG A 330 15.505 -14.389 -4.391 1.00 97.77 N \\\\nATOM 2595 NH1 ARG A 330 16.166 -13.356 -6.344 1.00 97.77 N \\\\nATOM 2596 NH2 ARG A 330 16.360 -15.551 -6.138 1.00 97.77 N \\\\nATOM 2597 CZ ARG A 330 16.011 -14.419 -5.612 1.00 97.77 C \\\\nATOM 2598 N HIS A 331 11.891 -8.714 -2.261 1.00 97.91 N \\\\nATOM 2599 CA HIS A 331 11.701 -7.631 -1.292 1.00 97.91 C \\\\nATOM 2600 C HIS A 331 10.309 -6.993 -1.356 1.00 97.91 C \\\\nATOM 2601 CB HIS A 331 12.799 -6.580 -1.485 1.00 97.91 C \\\\nATOM 2602 O HIS A 331 9.998 -6.134 -0.536 1.00 97.91 O \\\\nATOM 2603 CG HIS A 331 14.171 -7.075 -1.124 1.00 97.91 C \\\\nATOM 2604 CD2 HIS A 331 14.804 -6.915 0.079 1.00 97.91 C \\\\nATOM 2605 ND1 HIS A 331 15.028 -7.762 -1.952 1.00 97.91 N \\\\nATOM 2606 CE1 HIS A 331 16.153 -8.011 -1.265 1.00 97.91 C \\\\nATOM 2607 NE2 HIS A 331 16.067 -7.506 -0.028 1.00 97.91 N \\\\nATOM 2608 N ILE A 332 9.444 -7.410 -2.291 1.00 98.33 N \\\\nATOM 2609 CA ILE A 332 8.044 -6.968 -2.289 1.00 98.33 C \\\\nATOM 2610 C ILE A 332 7.382 -7.439 -0.989 1.00 98.33 C \\\\nATOM 2611 CB ILE A 332 7.289 -7.454 -3.548 1.00 98.33 C \\\\nATOM 2612 O ILE A 332 6.767 -6.633 -0.291 1.00 98.33 O \\\\nATOM 2613 CG1 ILE A 332 7.951 -6.868 -4.816 1.00 98.33 C \\\\nATOM 2614 CG2 ILE A 332 5.803 -7.051 -3.477 1.00 98.33 C \\\\nATOM 2615 CD1 ILE A 332 7.322 -7.321 -6.138 1.00 98.33 C \\\\nATOM 2616 N GLY A 333 7.564 -8.710 -0.613 1.00 96.97 N \\\\nATOM 2617 CA GLY A 333 7.011 -9.267 0.622 1.00 96.97 C \\\\nATOM 2618 C GLY A 333 5.499 -9.059 0.688 1.00 96.97 C \\\\nATOM 2619 O GLY A 333 4.781 -9.431 -0.234 1.00 96.97 O \\\\nATOM 2620 N ARG A 334 5.014 -8.404 1.747 1.00 96.99 N \\\\nATOM 2621 CA ARG A 334 3.590 -8.052 1.914 1.00 96.99 C \\\\nATOM 2622 C ARG A 334 3.105 -6.923 0.990 1.00 96.99 C \\\\nATOM 2623 CB ARG A 334 3.332 -7.682 3.376 1.00 96.99 C \\\\nATOM 2624 O ARG A 334 1.907 -6.669 0.949 1.00 96.99 O \\\\nATOM 2625 CG ARG A 334 3.610 -8.820 4.371 1.00 96.99 C \\\\nATOM 2626 CD ARG A 334 3.509 -8.312 5.813 1.00 96.99 C \\\\nATOM 2627 NE ARG A 334 2.156 -7.801 6.116 1.00 96.99 N \\\\nATOM 2628 NH1 ARG A 334 2.778 -6.270 7.713 1.00 96.99 N \\\\nATOM 2629 NH2 ARG A 334 0.650 -6.379 7.050 1.00 96.99 N \\\\nATOM 2630 CZ ARG A 334 1.871 -6.829 6.963 1.00 96.99 C \\\\nATOM 2631 N GLY A 335 4.019 -6.256 0.284 1.00 97.95 N \\\\nATOM 2632 CA GLY A 335 3.738 -5.303 -0.786 1.00 97.95 C \\\\nATOM 2633 C GLY A 335 2.956 -4.063 -0.355 1.00 97.95 C \\\\nATOM 2634 O GLY A 335 3.332 -3.387 0.604 1.00 97.95 O \\\\nATOM 2635 N VAL A 336 1.898 -3.735 -1.094 1.00 98.47 N \\\\nATOM 2636 CA VAL A 336 1.054 -2.552 -0.872 1.00 98.47 C \\\\nATOM 2637 C VAL A 336 -0.393 -2.973 -0.664 1.00 98.47 C \\\\nATOM 2638 CB VAL A 336 1.204 -1.522 -2.012 1.00 98.47 C \\\\nATOM 2639 O VAL A 336 -0.916 -3.807 -1.401 1.00 98.47 O \\\\nATOM 2640 CG1 VAL A 336 0.789 -2.047 -3.392 1.00 98.47 C \\\\nATOM 2641 CG2 VAL A 336 0.412 -0.237 -1.741 1.00 98.47 C \\\\nATOM 2642 N ARG A 337 -1.062 -2.375 0.322 1.00 97.58 N \\\\nATOM 2643 CA ARG A 337 -2.518 -2.443 0.435 1.00 97.58 C \\\\nATOM 2644 C ARG A 337 -3.132 -1.201 -0.182 1.00 97.58 C \\\\nATOM 2645 CB ARG A 337 -2.931 -2.656 1.887 1.00 97.58 C \\\\nATOM 2646 O ARG A 337 -2.751 -0.086 0.167 1.00 97.58 O \\\\nATOM 2647 CG ARG A 337 -4.458 -2.695 2.038 1.00 97.58 C \\\\nATOM 2648 CD ARG A 337 -4.849 -2.850 3.499 1.00 97.58 C \\\\nATOM 2649 NE ARG A 337 -4.440 -4.165 4.015 1.00 97.58 N \\\\nATOM 2650 NH1 ARG A 337 -4.005 -3.476 6.154 1.00 97.58 N \\\\nATOM 2651 NH2 ARG A 337 -4.062 -5.673 5.649 1.00 97.58 N \\\\nATOM 2652 CZ ARG A 337 -4.166 -4.427 5.272 1.00 97.58 C \\\\nATOM 2653 N LEU A 338 -4.098 -1.415 -1.063 1.00 97.59 N \\\\nATOM 2654 CA LEU A 338 -4.912 -0.367 -1.655 1.00 97.59 C \\\\nATOM 2655 C LEU A 338 -6.320 -0.481 -1.098 1.00 97.59 C \\\\nATOM 2656 CB LEU A 338 -4.897 -0.468 -3.187 1.00 97.59 C \\\\nATOM 2657 O LEU A 338 -6.879 -1.579 -1.059 1.00 97.59 O \\\\nATOM 2658 CG LEU A 338 -3.497 -0.423 -3.817 1.00 97.59 C \\\\nATOM 2659 CD1 LEU A 338 -3.606 -0.648 -5.321 1.00 97.59 C \\\\nATOM 2660 CD2 LEU A 338 -2.817 0.921 -3.570 1.00 97.59 C \\\\nATOM 2661 N TYR A 339 -6.886 0.635 -0.657 1.00 94.29 N \\\\nATOM 2662 CA TYR A 339 -8.265 0.657 -0.192 1.00 94.29 C \\\\nATOM 2663 C TYR A 339 -9.008 1.896 -0.686 1.00 94.29 C \\\\nATOM 2664 CB TYR A 339 -8.335 0.456 1.329 1.00 94.29 C \\\\nATOM 2665 O TYR A 339 -8.458 2.998 -0.687 1.00 94.29 O \\\\nATOM 2666 CG TYR A 339 -7.543 1.443 2.169 1.00 94.29 C \\\\nATOM 2667 CD1 TYR A 339 -6.210 1.165 2.529 1.00 94.29 C \\\\nATOM 2668 CD2 TYR A 339 -8.145 2.635 2.605 1.00 94.29 C \\\\nATOM 2669 CE1 TYR A 339 -5.487 2.074 3.325 1.00 94.29 C \\\\nATOM 2670 CE2 TYR A 339 -7.443 3.529 3.435 1.00 94.29 C \\\\nATOM 2671 OH TYR A 339 -5.372 4.184 4.461 1.00 94.29 O \\\\nATOM 2672 CZ TYR A 339 -6.099 3.260 3.778 1.00 94.29 C \\\\nATOM 2673 N TYR A 340 -10.252 1.677 -1.109 1.00 94.08 N \\\\nATOM 2674 CA TYR A 340 -11.198 2.666 -1.603 1.00 94.08 C \\\\nATOM 2675 C TYR A 340 -12.298 2.883 -0.566 1.00 94.08 C \\\\nATOM 2676 CB TYR A 340 -11.787 2.203 -2.940 1.00 94.08 C \\\\nATOM 2677 O TYR A 340 -13.059 1.967 -0.251 1.00 94.08 O \\\\nATOM 2678 CG TYR A 340 -12.829 3.157 -3.495 1.00 94.08 C \\\\nATOM 2679 CD1 TYR A 340 -14.131 2.706 -3.792 1.00 94.08 C \\\\nATOM 2680 CD2 TYR A 340 -12.493 4.507 -3.719 1.00 94.08 C \\\\nATOM 2681 CE1 TYR A 340 -15.084 3.595 -4.329 1.00 94.08 C \\\\nATOM 2682 CE2 TYR A 340 -13.440 5.394 -4.262 1.00 94.08 C \\\\nATOM 2683 OH TYR A 340 -15.648 5.811 -5.089 1.00 94.08 O \\\\nATOM 2684 CZ TYR A 340 -14.740 4.941 -4.572 1.00 94.08 C \\\\nATOM 2685 N ILE A 341 -12.338 4.078 0.021 1.00 89.81 N \\\\nATOM 2686 CA ILE A 341 -13.234 4.410 1.131 1.00 89.81 C \\\\nATOM 2687 C ILE A 341 -13.700 5.849 0.976 1.00 89.81 C \\\\nATOM 2688 CB ILE A 341 -12.529 4.199 2.489 1.00 89.81 C \\\\nATOM 2689 O ILE A 341 -12.882 6.758 0.866 1.00 89.81 O \\\\nATOM 2690 CG1 ILE A 341 -12.080 2.726 2.624 1.00 89.81 C \\\\nATOM 2691 CG2 ILE A 341 -13.460 4.596 3.652 1.00 89.81 C \\\\nATOM 2692 CD1 ILE A 341 -11.307 2.440 3.893 1.00 89.81 C \\\\nATOM 2693 N GLY A 342 -15.016 6.063 0.993 1.00 86.14 N \\\\nATOM 2694 CA GLY A 342 -15.597 7.405 0.992 1.00 86.14 C \\\\nATOM 2695 C GLY A 342 -15.259 8.241 -0.249 1.00 86.14 C \\\\nATOM 2696 O GLY A 342 -15.158 9.458 -0.142 1.00 86.14 O \\\\nATOM 2697 N GLY A 343 -15.028 7.616 -1.409 1.00 91.06 N \\\\nATOM 2698 CA GLY A 343 -14.581 8.324 -2.616 1.00 91.06 C \\\\nATOM 2699 C GLY A 343 -13.084 8.656 -2.634 1.00 91.06 C \\\\nATOM 2700 O GLY A 343 -12.636 9.430 -3.477 1.00 91.06 O \\\\nATOM 2701 N GLU A 344 -12.297 8.093 -1.718 1.00 95.31 N \\\\nATOM 2702 CA GLU A 344 -10.852 8.298 -1.624 1.00 95.31 C \\\\nATOM 2703 C GLU A 344 -10.106 6.972 -1.770 1.00 95.31 C \\\\nATOM 2704 CB GLU A 344 -10.482 8.970 -0.295 1.00 95.31 C \\\\nATOM 2705 O GLU A 344 -10.546 5.940 -1.260 1.00 95.31 O \\\\nATOM 2706 CG GLU A 344 -11.302 10.232 -0.002 1.00 95.31 C \\\\nATOM 2707 CD GLU A 344 -10.703 11.044 1.148 1.00 95.31 C \\\\nATOM 2708 OE1 GLU A 344 -10.492 12.263 0.951 1.00 95.31 O \\\\nATOM 2709 OE2 GLU A 344 -10.289 10.495 2.196 1.00 95.31 O \\\\nATOM 2710 N VAL A 345 -8.951 6.998 -2.437 1.00 97.02 N \\\\nATOM 2711 CA VAL A 345 -8.064 5.834 -2.562 1.00 97.02 C \\\\nATOM 2712 C VAL A 345 -6.793 6.093 -1.773 1.00 97.02 C \\\\nATOM 2713 CB VAL A 345 -7.734 5.471 -4.021 1.00 97.02 C \\\\nATOM 2714 O VAL A 345 -6.159 7.145 -1.907 1.00 97.02 O \\\\nATOM 2715 CG1 VAL A 345 -6.968 4.143 -4.103 1.00 97.02 C \\\\nATOM 2716 CG2 VAL A 345 -8.986 5.315 -4.892 1.00 97.02 C \\\\nATOM 2717 N PHE A 346 -6.380 5.106 -0.989 1.00 97.07 N \\\\nATOM 2718 CA PHE A 346 -5.151 5.148 -0.209 1.00 97.07 C \\\\nATOM 2719 C PHE A 346 -4.224 3.991 -0.574 1.00 97.07 C \\\\nATOM 2720 CB PHE A 346 -5.493 5.078 1.271 1.00 97.07 C \\\\nATOM 2721 O PHE A 346 -4.683 2.895 -0.893 1.00 97.07 O \\\\nATOM 2722 CG PHE A 346 -6.297 6.235 1.835 1.00 97.07 C \\\\nATOM 2723 CD1 PHE A 346 -5.655 7.239 2.584 1.00 97.07 C \\\\nATOM 2724 CD2 PHE A 346 -7.695 6.276 1.669 1.00 97.07 C \\\\nATOM 2725 CE1 PHE A 346 -6.405 8.281 3.159 1.00 97.07 C \\\\nATOM 2726 CE2 PHE A 346 -8.443 7.312 2.250 1.00 97.07 C \\\\nATOM 2727 CZ PHE A 346 -7.800 8.318 2.989 1.00 97.07 C \\\\nATOM 2728 N ALA A 347 -2.919 4.234 -0.463 1.00 97.96 N \\\\nATOM 2729 CA ALA A 347 -1.883 3.211 -0.516 1.00 97.96 C \\\\nATOM 2730 C ALA A 347 -1.181 3.105 0.840 1.00 97.96 C \\\\nATOM 2731 CB ALA A 347 -0.893 3.540 -1.640 1.00 97.96 C \\\\nATOM 2732 O ALA A 347 -0.631 4.091 1.324 1.00 97.96 O \\\\nATOM 2733 N GLU A 348 -1.175 1.913 1.434 1.00 97.60 N \\\\nATOM 2734 CA GLU A 348 -0.460 1.568 2.668 1.00 97.60 C \\\\nATOM 2735 C GLU A 348 0.707 0.628 2.335 1.00 97.60 C \\\\nATOM 2736 CB GLU A 348 -1.450 0.952 3.679 1.00 97.60 C \\\\nATOM 2737 O GLU A 348 0.514 -0.455 1.775 1.00 97.60 O \\\\nATOM 2738 CG GLU A 348 -0.813 0.537 5.019 1.00 97.60 C \\\\nATOM 2739 CD GLU A 348 -1.741 -0.274 5.959 1.00 97.60 C \\\\nATOM 2740 OE1 GLU A 348 -1.431 -0.329 7.170 1.00 97.60 O \\\\nATOM 2741 OE2 GLU A 348 -2.691 -0.964 5.499 1.00 97.60 O \\\\nATOM 2742 N CYS A 349 1.932 1.025 2.684 1.00 97.68 N \\\\nATOM 2743 CA CYS A 349 3.120 0.208 2.464 1.00 97.68 C \\\\nATOM 2744 C CYS A 349 3.221 -0.877 3.542 1.00 97.68 C \\\\nATOM 2745 CB CYS A 349 4.354 1.110 2.436 1.00 97.68 C \\\\nATOM 2746 O CYS A 349 3.591 -0.606 4.685 1.00 97.68 O \\\\nATOM 2747 SG CYS A 349 5.812 0.141 1.956 1.00 97.68 S \\\\nATOM 2748 N LEU A 350 2.915 -2.121 3.168 1.00 97.08 N \\\\nATOM 2749 CA LEU A 350 3.031 -3.288 4.046 1.00 97.08 C \\\\nATOM 2750 C LEU A 350 4.384 -3.999 3.924 1.00 97.08 C \\\\nATOM 2751 CB LEU A 350 1.897 -4.273 3.731 1.00 97.08 C \\\\nATOM 2752 O LEU A 350 4.718 -4.808 4.790 1.00 97.08 O \\\\nATOM 2753 CG LEU A 350 0.470 -3.734 3.912 1.00 97.08 C \\\\nATOM 2754 CD1 LEU A 350 -0.500 -4.899 3.700 1.00 97.08 C \\\\nATOM 2755 CD2 LEU A 350 0.237 -3.171 5.314 1.00 97.08 C \\\\nATOM 2756 N SER A 351 5.112 -3.742 2.837 1.00 97.55 N \\\\nATOM 2757 CA SER A 351 6.471 -4.219 2.599 1.00 97.55 C \\\\nATOM 2758 C SER A 351 7.459 -3.616 3.600 1.00 97.55 C \\\\nATOM 2759 CB SER A 351 6.889 -3.842 1.174 1.00 97.55 C \\\\nATOM 2760 O SER A 351 7.312 -2.464 4.008 1.00 97.55 O \\\\nATOM 2761 OG SER A 351 8.183 -4.338 0.888 1.00 97.55 O \\\\nATOM 2762 N ASP A 352 8.506 -4.376 3.928 1.00 97.73 N \\\\nATOM 2763 CA ASP A 352 9.672 -3.889 4.679 1.00 97.73 C \\\\nATOM 2764 C ASP A 352 10.552 -2.948 3.829 1.00 97.73 C \\\\nATOM 2765 CB ASP A 352 10.497 -5.086 5.177 1.00 97.73 C \\\\nATOM 2766 O ASP A 352 11.463 -2.295 4.335 1.00 97.73 O \\\\nATOM 2767 CG ASP A 352 9.687 -6.060 6.040 1.00 97.73 C \\\\nATOM 2768 OD1 ASP A 352 8.900 -5.590 6.891 1.00 97.73 O \\\\nATOM 2769 OD2 ASP A 352 9.822 -7.280 5.800 1.00 97.73 O \\\\nATOM 2770 N SER A 353 10.281 -2.861 2.523 1.00 97.87 N \\\\nATOM 2771 CA SER A 353 10.881 -1.908 1.590 1.00 97.87 C \\\\nATOM 2772 C SER A 353 9.872 -0.838 1.176 1.00 97.87 C \\\\nATOM 2773 CB SER A 353 11.387 -2.646 0.355 1.00 97.87 C \\\\nATOM 2774 O SER A 353 8.687 -1.110 1.029 1.00 97.87 O \\\\nATOM 2775 OG SER A 353 12.472 -3.474 0.711 1.00 97.87 O \\\\nATOM 2776 N ALA A 354 10.346 0.386 0.938 1.00 98.19 N \\\\nATOM 2777 CA ALA A 354 9.480 1.481 0.503 1.00 98.19 C \\\\nATOM 2778 C ALA A 354 8.854 1.226 -0.880 1.00 98.19 C \\\\nATOM 2779 CB ALA A 354 10.281 2.789 0.517 1.00 98.19 C \\\\nATOM 2780 O ALA A 354 9.454 0.578 -1.746 1.00 98.19 O \\\\nATOM 2781 N ILE A 355 7.686 1.826 -1.100 1.00 98.61 N \\\\nATOM 2782 CA ILE A 355 7.050 1.953 -2.416 1.00 98.61 C \\\\nATOM 2783 C ILE A 355 7.110 3.408 -2.884 1.00 98.61 C \\\\nATOM 2784 CB ILE A 355 5.617 1.375 -2.426 1.00 98.61 C \\\\nATOM 2785 O ILE A 355 7.277 4.332 -2.086 1.00 98.61 O \\\\nATOM 2786 CG1 ILE A 355 4.688 2.175 -1.494 1.00 98.61 C \\\\nATOM 2787 CG2 ILE A 355 5.653 -0.123 -2.075 1.00 98.61 C \\\\nATOM 2788 CD1 ILE A 355 3.241 1.685 -1.442 1.00 98.61 C \\\\nATOM 2789 N PHE A 356 6.994 3.616 -4.188 1.00 98.53 N \\\\nATOM 2790 CA PHE A 356 7.125 4.925 -4.823 1.00 98.53 C \\\\nATOM 2791 C PHE A 356 5.921 5.140 -5.721 1.00 98.53 C \\\\nATOM 2792 CB PHE A 356 8.440 4.970 -5.608 1.00 98.53 C \\\\nATOM 2793 O PHE A 356 5.652 4.287 -6.556 1.00 98.53 O \\\\nATOM 2794 CG PHE A 356 9.661 4.735 -4.752 1.00 98.53 C \\\\nATOM 2795 CD1 PHE A 356 10.376 5.816 -4.206 1.00 98.53 C \\\\nATOM 2796 CD2 PHE A 356 10.061 3.416 -4.470 1.00 98.53 C \\\\nATOM 2797 CE1 PHE A 356 11.488 5.562 -3.384 1.00 98.53 C \\\\nATOM 2798 CE2 PHE A 356 11.152 3.175 -3.623 1.00 98.53 C \\\\nATOM 2799 CZ PHE A 356 11.881 4.248 -3.096 1.00 98.53 C \\\\nATOM 2800 N VAL A 357 5.184 6.229 -5.533 1.00 98.21 N \\\\nATOM 2801 CA VAL A 357 3.879 6.458 -6.159 1.00 98.21 C \\\\nATOM 2802 C VAL A 357 3.912 7.739 -6.975 1.00 98.21 C \\\\nATOM 2803 CB VAL A 357 2.761 6.519 -5.101 1.00 98.21 C \\\\nATOM 2804 O VAL A 357 4.269 8.792 -6.458 1.00 98.21 O \\\\nATOM 2805 CG1 VAL A 357 1.389 6.733 -5.755 1.00 98.21 C \\\\nATOM 2806 CG2 VAL A 357 2.726 5.232 -4.262 1.00 98.21 C \\\\nATOM 2807 N GLN A 358 3.482 7.661 -8.228 1.00 98.17 N \\\\nATOM 2808 CA GLN A 358 3.169 8.813 -9.064 1.00 98.17 C \\\\nATOM 2809 C GLN A 358 1.657 8.841 -9.264 1.00 98.17 C \\\\nATOM 2810 CB GLN A 358 3.941 8.699 -10.381 1.00 98.17 C \\\\nATOM 2811 O GLN A 358 1.110 8.033 -10.017 1.00 98.17 O \\\\nATOM 2812 CG GLN A 358 3.722 9.881 -11.334 1.00 98.17 C \\\\nATOM 2813 CD GLN A 358 4.458 9.662 -12.654 1.00 98.17 C \\\\nATOM 2814 NE2 GLN A 358 5.532 10.379 -12.912 1.00 98.17 N \\\\nATOM 2815 OE1 GLN A 358 4.105 8.810 -13.458 1.00 98.17 O \\\\nATOM 2816 N SER A 359 0.989 9.755 -8.561 1.00 97.96 N \\\\nATOM 2817 CA SER A 359 -0.434 10.039 -8.743 1.00 97.96 C \\\\nATOM 2818 C SER A 359 -0.601 11.513 -9.107 1.00 97.96 C \\\\nATOM 2819 CB SER A 359 -1.239 9.712 -7.487 1.00 97.96 C \\\\nATOM 2820 O SER A 359 -0.374 12.367 -8.244 1.00 97.96 O \\\\nATOM 2821 OG SER A 359 -2.534 10.252 -7.659 1.00 97.96 O \\\\nATOM 2822 N PRO A 360 -1.021 11.832 -10.342 1.00 97.02 N \\\\nATOM 2823 CA PRO A 360 -1.266 13.212 -10.746 1.00 97.02 C \\\\nATOM 2824 C PRO A 360 -2.301 13.928 -9.861 1.00 97.02 C \\\\nATOM 2825 CB PRO A 360 -1.701 13.112 -12.207 1.00 97.02 C \\\\nATOM 2826 O PRO A 360 -2.092 15.082 -9.499 1.00 97.02 O \\\\nATOM 2827 CG PRO A 360 -0.983 11.862 -12.707 1.00 97.02 C \\\\nATOM 2828 CD PRO A 360 -1.102 10.942 -11.498 1.00 97.02 C \\\\nATOM 2829 N ASN A 361 -3.351 13.228 -9.408 1.00 97.36 N \\\\nATOM 2830 CA ASN A 361 -4.341 13.769 -8.464 1.00 97.36 C \\\\nATOM 2831 C ASN A 361 -3.713 14.156 -7.117 1.00 97.36 C \\\\nATOM 2832 CB ASN A 361 -5.472 12.738 -8.310 1.00 97.36 C \\\\nATOM 2833 O ASN A 361 -3.924 15.261 -6.622 1.00 97.36 O \\\\nATOM 2834 CG ASN A 361 -6.573 13.205 -7.372 1.00 97.36 C \\\\nATOM 2835 ND2 ASN A 361 -7.574 13.894 -7.865 1.00 97.36 N \\\\nATOM 2836 OD1 ASN A 361 -6.548 12.926 -6.183 1.00 97.36 O \\\\nATOM 2837 N CYS A 362 -2.876 13.280 -6.556 1.00 96.14 N \\\\nATOM 2838 CA CYS A 362 -2.138 13.572 -5.328 1.00 96.14 C \\\\nATOM 2839 C CYS A 362 -1.158 14.740 -5.520 1.00 96.14 C \\\\nATOM 2840 CB CYS A 362 -1.401 12.295 -4.912 1.00 96.14 C \\\\nATOM 2841 O CYS A 362 -1.072 15.621 -4.668 1.00 96.14 O \\\\nATOM 2842 SG CYS A 362 -0.540 12.518 -3.334 1.00 96.14 S \\\\nATOM 2843 N ASN A 363 -0.430 14.758 -6.637 1.00 96.49 N \\\\nATOM 2844 CA ASN A 363 0.555 15.793 -6.934 1.00 96.49 C \\\\nATOM 2845 C ASN A 363 -0.107 17.169 -7.060 1.00 96.49 C \\\\nATOM 2846 CB ASN A 363 1.332 15.387 -8.199 1.00 96.49 C \\\\nATOM 2847 O ASN A 363 0.365 18.123 -6.448 1.00 96.49 O \\\\nATOM 2848 CG ASN A 363 2.246 14.195 -7.964 1.00 96.49 C \\\\nATOM 2849 ND2 ASN A 363 2.709 13.537 -8.998 1.00 96.49 N \\\\nATOM 2850 OD1 ASN A 363 2.590 13.845 -6.847 1.00 96.49 O \\\\nATOM 2851 N GLN A 364 -1.248 17.251 -7.749 1.00 95.57 N \\\\nATOM 2852 CA GLN A 364 -2.022 18.483 -7.863 1.00 95.57 C \\\\nATOM 2853 C GLN A 364 -2.529 18.980 -6.503 1.00 95.57 C \\\\nATOM 2854 CB GLN A 364 -3.164 18.253 -8.857 1.00 95.57 C \\\\nATOM 2855 O GLN A 364 -2.400 20.168 -6.215 1.00 95.57 O \\\\nATOM 2856 CG GLN A 364 -3.989 19.528 -9.096 1.00 95.57 C \\\\nATOM 2857 CD GLN A 364 -4.957 19.385 -10.265 1.00 95.57 C \\\\nATOM 2858 NE2 GLN A 364 -5.916 20.272 -10.402 1.00 95.57 N \\\\nATOM 2859 OE1 GLN A 364 -4.870 18.483 -11.078 1.00 95.57 O \\\\nATOM 2860 N ARG A 365 -3.030 18.089 -5.632 1.00 95.41 N \\\\nATOM 2861 CA ARG A 365 -3.483 18.449 -4.273 1.00 95.41 C \\\\nATOM 2862 C ARG A 365 -2.396 19.155 -3.458 1.00 95.41 C \\\\nATOM 2863 CB ARG A 365 -3.955 17.182 -3.540 1.00 95.41 C \\\\nATOM 2864 O ARG A 365 -2.692 20.091 -2.721 1.00 95.41 O \\\\nATOM 2865 CG ARG A 365 -4.554 17.483 -2.151 1.00 95.41 C \\\\nATOM 2866 CD ARG A 365 -4.732 16.213 -1.315 1.00 95.41 C \\\\nATOM 2867 NE ARG A 365 -5.657 15.286 -1.972 1.00 95.41 N \\\\nATOM 2868 NH1 ARG A 365 -4.525 13.324 -1.744 1.00 95.41 N \\\\nATOM 2869 NH2 ARG A 365 -6.301 13.471 -3.120 1.00 95.41 N \\\\nATOM 2870 CZ ARG A 365 -5.495 14.021 -2.269 1.00 95.41 C \\\\nATOM 2871 N TYR A 366 -1.151 18.699 -3.571 1.00 94.64 N \\\\nATOM 2872 CA TYR A 366 -0.016 19.262 -2.833 1.00 94.64 C \\\\nATOM 2873 C TYR A 366 0.746 20.354 -3.601 1.00 94.64 C \\\\nATOM 2874 CB TYR A 366 0.897 18.124 -2.357 1.00 94.64 C \\\\nATOM 2875 O TYR A 366 1.752 20.850 -3.098 1.00 94.64 O \\\\nATOM 2876 CG TYR A 366 0.253 17.198 -1.339 1.00 94.64 C \\\\nATOM 2877 CD1 TYR A 366 -0.097 17.689 -0.066 1.00 94.64 C \\\\nATOM 2878 CD2 TYR A 366 0.010 15.849 -1.656 1.00 94.64 C \\\\nATOM 2879 CE1 TYR A 366 -0.699 16.839 0.883 1.00 94.64 C \\\\nATOM 2880 CE2 TYR A 366 -0.598 14.996 -0.716 1.00 94.64 C \\\\nATOM 2881 OH TYR A 366 -1.546 14.667 1.459 1.00 94.64 O \\\\nATOM 2882 CZ TYR A 366 -0.953 15.490 0.554 1.00 94.64 C \\\\nATOM 2883 N GLY A 367 0.293 20.740 -4.800 1.00 95.30 N \\\\nATOM 2884 CA GLY A 367 0.976 21.736 -5.634 1.00 95.30 C \\\\nATOM 2885 C GLY A 367 2.334 21.268 -6.168 1.00 95.30 C \\\\nATOM 2886 O GLY A 367 3.211 22.085 -6.441 1.00 95.30 O \\\\nATOM 2887 N TRP A 368 2.542 19.957 -6.288 1.00 95.17 N \\\\nATOM 2888 CA TRP A 368 3.743 19.377 -6.881 1.00 95.17 C \\\\nATOM 2889 C TRP A 368 3.590 19.216 -8.391 1.00 95.17 C \\\\nATOM 2890 CB TRP A 368 4.063 18.034 -6.218 1.00 95.17 C \\\\nATOM 2891 O TRP A 368 2.484 19.074 -8.910 1.00 95.17 O \\\\nATOM 2892 CG TRP A 368 4.353 18.072 -4.751 1.00 95.17 C \\\\nATOM 2893 CD1 TRP A 368 4.860 19.125 -4.069 1.00 95.17 C \\\\nATOM 2894 CD2 TRP A 368 4.110 17.033 -3.755 1.00 95.17 C \\\\nATOM 2895 CE2 TRP A 368 4.511 17.533 -2.480 1.00 95.17 C \\\\nATOM 2896 CE3 TRP A 368 3.550 15.737 -3.790 1.00 95.17 C \\\\nATOM 2897 NE1 TRP A 368 4.962 18.809 -2.732 1.00 95.17 N \\\\nATOM 2898 CH2 TRP A 368 3.799 15.509 -1.367 1.00 95.17 C \\\\nATOM 2899 CZ2 TRP A 368 4.378 16.786 -1.301 1.00 95.17 C \\\\nATOM 2900 CZ3 TRP A 368 3.374 14.997 -2.605 1.00 95.17 C \\\\nATOM 2901 N HIS A 369 4.722 19.151 -9.096 1.00 95.30 N \\\\nATOM 2902 CA HIS A 369 4.724 18.820 -10.518 1.00 95.30 C \\\\nATOM 2903 C HIS A 369 3.951 17.502 -10.767 1.00 95.30 C \\\\nATOM 2904 CB HIS A 369 6.175 18.730 -11.012 1.00 95.30 C \\\\nATOM 2905 O HIS A 369 4.157 16.543 -10.016 1.00 95.30 O \\\\nATOM 2906 CG HIS A 369 6.259 18.606 -12.508 1.00 95.30 C \\\\nATOM 2907 CD2 HIS A 369 6.255 19.634 -13.411 1.00 95.30 C \\\\nATOM 2908 ND1 HIS A 369 6.303 17.435 -13.227 1.00 95.30 N \\\\nATOM 2909 CE1 HIS A 369 6.308 17.747 -14.536 1.00 95.30 C \\\\nATOM 2910 NE2 HIS A 369 6.277 19.073 -14.687 1.00 95.30 N \\\\nATOM 2911 N PRO A 370 3.101 17.384 -11.811 1.00 93.40 N \\\\nATOM 2912 CA PRO A 370 2.279 16.186 -12.047 1.00 93.40 C \\\\nATOM 2913 C PRO A 370 3.077 14.876 -12.133 1.00 93.40 C \\\\nATOM 2914 CB PRO A 370 1.543 16.461 -13.362 1.00 93.40 C \\\\nATOM 2915 O PRO A 370 2.563 13.802 -11.826 1.00 93.40 O \\\\nATOM 2916 CG PRO A 370 1.414 17.981 -13.379 1.00 93.40 C \\\\nATOM 2917 CD PRO A 370 2.718 18.445 -12.736 1.00 93.40 C \\\\nATOM 2918 N ALA A 371 4.357 14.974 -12.496 1.00 94.38 N \\\\nATOM 2919 CA ALA A 371 5.297 13.861 -12.604 1.00 94.38 C \\\\nATOM 2920 C ALA A 371 5.973 13.426 -11.297 1.00 94.38 C \\\\nATOM 2921 CB ALA A 371 6.387 14.274 -13.578 1.00 94.38 C \\\\nATOM 2922 O ALA A 371 6.759 12.473 -11.329 1.00 94.38 O \\\\nATOM 2923 N THR A 372 5.744 14.139 -10.194 1.00 95.75 N \\\\nATOM 2924 CA THR A 372 6.399 13.888 -8.909 1.00 95.75 C \\\\nATOM 2925 C THR A 372 6.146 12.462 -8.433 1.00 95.75 C \\\\nATOM 2926 CB THR A 372 5.952 14.920 -7.865 1.00 95.75 C \\\\nATOM 2927 O THR A 372 5.046 11.922 -8.567 1.00 95.75 O \\\\nATOM 2928 CG2 THR A 372 6.466 14.662 -6.449 1.00 95.75 C \\\\nATOM 2929 OG1 THR A 372 6.486 16.161 -8.254 1.00 95.75 O \\\\nATOM 2930 N VAL A 373 7.196 11.851 -7.883 1.00 97.76 N \\\\nATOM 2931 CA VAL A 373 7.174 10.489 -7.352 1.00 97.76 C \\\\nATOM 2932 C VAL A 373 7.317 10.554 -5.835 1.00 97.76 C \\\\nATOM 2933 CB VAL A 373 8.270 9.626 -7.999 1.00 97.76 C \\\\nATOM 2934 O VAL A 373 8.382 10.863 -5.303 1.00 97.76 O \\\\nATOM 2935 CG1 VAL A 373 8.211 8.193 -7.461 1.00 97.76 C \\\\nATOM 2936 CG2 VAL A 373 8.108 9.574 -9.523 1.00 97.76 C \\\\nATOM 2937 N CYS A 374 6.238 10.243 -5.128 1.00 96.60 N \\\\nATOM 2938 CA CYS A 374 6.176 10.254 -3.674 1.00 96.60 C \\\\nATOM 2939 C CYS A 374 6.661 8.916 -3.110 1.00 96.60 C \\\\nATOM 2940 CB CYS A 374 4.736 10.540 -3.234 1.00 96.60 C \\\\nATOM 2941 O CYS A 374 6.140 7.856 -3.455 1.00 96.60 O \\\\nATOM 2942 SG CYS A 374 4.133 12.066 -4.000 1.00 96.60 S \\\\nATOM 2943 N LYS A 375 7.632 8.944 -2.196 1.00 97.82 N \\\\nATOM 2944 CA LYS A 375 8.061 7.751 -1.455 1.00 97.82 C \\\\nATOM 2945 C LYS A 375 7.115 7.495 -0.279 1.00 97.82 C \\\\nATOM 2946 CB LYS A 375 9.514 7.947 -1.006 1.00 97.82 C \\\\nATOM 2947 O LYS A 375 6.924 8.382 0.546 1.00 97.82 O \\\\nATOM 2948 CG LYS A 375 10.077 6.726 -0.267 1.00 97.82 C \\\\nATOM 2949 CD LYS A 375 11.522 7.007 0.156 1.00 97.82 C \\\\nATOM 2950 CE LYS A 375 12.114 5.801 0.888 1.00 97.82 C \\\\nATOM 2951 NZ LYS A 375 13.500 6.086 1.337 1.00 97.82 N \\\\nATOM 2952 N ILE A 376 6.602 6.272 -0.154 1.00 97.37 N \\\\nATOM 2953 CA ILE A 376 5.853 5.795 1.017 1.00 97.37 C \\\\nATOM 2954 C ILE A 376 6.740 4.781 1.759 1.00 97.37 C \\\\nATOM 2955 CB ILE A 376 4.485 5.196 0.624 1.00 97.37 C \\\\nATOM 2956 O ILE A 376 6.971 3.680 1.248 1.00 97.37 O \\\\nATOM 2957 CG1 ILE A 376 3.673 6.151 -0.281 1.00 97.37 C \\\\nATOM 2958 CG2 ILE A 376 3.690 4.828 1.893 1.00 97.37 C \\\\nATOM 2959 CD1 ILE A 376 2.346 5.562 -0.771 1.00 97.37 C \\\\nATOM 2960 N PRO A 377 7.299 5.143 2.929 1.00 97.58 N \\\\nATOM 2961 CA PRO A 377 8.103 4.230 3.740 1.00 97.58 C \\\\nATOM 2962 C PRO A 377 7.293 3.046 4.303 1.00 97.58 C \\\\nATOM 2963 CB PRO A 377 8.691 5.083 4.871 1.00 97.58 C \\\\nATOM 2964 O PRO A 377 6.067 3.136 4.395 1.00 97.58 O \\\\nATOM 2965 CG PRO A 377 8.623 6.511 4.334 1.00 97.58 C \\\\nATOM 2966 CD PRO A 377 7.356 6.487 3.489 1.00 97.58 C \\\\nATOM 2967 N PRO A 378 7.964 1.961 4.737 1.00 97.58 N \\\\nATOM 2968 CA PRO A 378 7.325 0.838 5.428 1.00 97.58 C \\\\nATOM 2969 C PRO A 378 6.428 1.283 6.590 1.00 97.58 C \\\\nATOM 2970 CB PRO A 378 8.480 -0.034 5.930 1.00 97.58 C \\\\nATOM 2971 O PRO A 378 6.843 2.075 7.434 1.00 97.58 O \\\\nATOM 2972 CG PRO A 378 9.568 0.224 4.894 1.00 97.58 C \\\\nATOM 2973 CD PRO A 378 9.391 1.707 4.591 1.00 97.58 C \\\\nATOM 2974 N GLY A 379 5.193 0.777 6.633 1.00 92.70 N \\\\nATOM 2975 CA GLY A 379 4.200 1.105 7.662 1.00 92.70 C \\\\nATOM 2976 C GLY A 379 3.500 2.459 7.491 1.00 92.70 C \\\\nATOM 2977 O GLY A 379 2.587 2.768 8.258 1.00 92.70 O \\\\nATOM 2978 N CYS A 380 3.885 3.268 6.500 1.00 95.04 N \\\\nATOM 2979 CA CYS A 380 3.205 4.520 6.177 1.00 95.04 C \\\\nATOM 2980 C CYS A 380 2.071 4.305 5.165 1.00 95.04 C \\\\nATOM 2981 CB CYS A 380 4.220 5.558 5.676 1.00 95.04 C \\\\nATOM 2982 O CYS A 380 2.049 3.328 4.415 1.00 95.04 O \\\\nATOM 2983 SG CYS A 380 5.459 5.922 6.954 1.00 95.04 S \\\\nATOM 2984 N ASN A 381 1.143 5.261 5.116 1.00 94.89 N \\\\nATOM 2985 CA ASN A 381 0.094 5.328 4.105 1.00 94.89 C \\\\nATOM 2986 C ASN A 381 0.009 6.730 3.486 1.00 94.89 C \\\\nATOM 2987 CB ASN A 381 -1.248 4.848 4.687 1.00 94.89 C \\\\nATOM 2988 O ASN A 381 0.466 7.703 4.085 1.00 94.89 O \\\\nATOM 2989 CG ASN A 381 -1.764 5.753 5.791 1.00 94.89 C \\\\nATOM 2990 ND2 ASN A 381 -1.454 5.453 7.031 1.00 94.89 N \\\\nATOM 2991 OD1 ASN A 381 -2.427 6.748 5.560 1.00 94.89 O \\\\nATOM 2992 N LEU A 382 -0.562 6.818 2.286 1.00 94.95 N \\\\nATOM 2993 CA LEU A 382 -0.778 8.062 1.549 1.00 94.95 C \\\\nATOM 2994 C LEU A 382 -2.145 8.028 0.863 1.00 94.95 C \\\\nATOM 2995 CB LEU A 382 0.357 8.226 0.521 1.00 94.95 C \\\\nATOM 2996 O LEU A 382 -2.516 7.012 0.275 1.00 94.95 O \\\\nATOM 2997 CG LEU A 382 0.314 9.514 -0.324 1.00 94.95 C \\\\nATOM 2998 CD1 LEU A 382 0.495 10.768 0.533 1.00 94.95 C \\\\nATOM 2999 CD2 LEU A 382 1.430 9.477 -1.368 1.00 94.95 C \\\\nATOM 3000 N LYS A 383 -2.872 9.150 0.889 1.00 96.88 N \\\\nATOM 3001 CA LYS A 383 -4.083 9.348 0.081 1.00 96.88 C \\\\nATOM 3002 C LYS A 383 -3.681 9.634 -1.363 1.00 96.88 C \\\\nATOM 3003 CB LYS A 383 -4.923 10.485 0.675 1.00 96.88 C \\\\nATOM 3004 O LYS A 383 -3.294 10.754 -1.690 1.00 96.88 O \\\\nATOM 3005 CG LYS A 383 -6.269 10.625 -0.058 1.00 96.88 C \\\\nATOM 3006 CD LYS A 383 -7.087 11.818 0.451 1.00 96.88 C \\\\nATOM 3007 CE LYS A 383 -7.420 11.669 1.938 1.00 96.88 C \\\\nATOM 3008 NZ LYS A 383 -8.317 12.746 2.405 1.00 96.88 N \\\\nATOM 3009 N ILE A 384 -3.771 8.626 -2.220 1.00 97.74 N \\\\nATOM 3010 CA ILE A 384 -3.300 8.703 -3.605 1.00 97.74 C \\\\nATOM 3011 C ILE A 384 -4.361 9.256 -4.559 1.00 97.74 C \\\\nATOM 3012 CB ILE A 384 -2.738 7.347 -4.082 1.00 97.74 C \\\\nATOM 3013 O ILE A 384 -3.991 9.710 -5.633 1.00 97.74 O \\\\nATOM 3014 CG1 ILE A 384 -3.828 6.254 -4.146 1.00 97.74 C \\\\nATOM 3015 CG2 ILE A 384 -1.557 6.924 -3.190 1.00 97.74 C \\\\nATOM 3016 CD1 ILE A 384 -3.349 4.937 -4.762 1.00 97.74 C \\\\nATOM 3017 N PHE A 385 -5.646 9.255 -4.196 1.00 97.98 N \\\\nATOM 3018 CA PHE A 385 -6.714 9.810 -5.034 1.00 97.98 C \\\\nATOM 3019 C PHE A 385 -7.903 10.309 -4.205 1.00 97.98 C \\\\nATOM 3020 CB PHE A 385 -7.190 8.749 -6.032 1.00 97.98 C \\\\nATOM 3021 O PHE A 385 -8.200 9.731 -3.159 1.00 97.98 O \\\\nATOM 3022 CG PHE A 385 -7.952 9.324 -7.205 1.00 97.98 C \\\\nATOM 3023 CD1 PHE A 385 -9.359 9.385 -7.181 1.00 97.98 C \\\\nATOM 3024 CD2 PHE A 385 -7.253 9.791 -8.333 1.00 97.98 C \\\\nATOM 3025 CE1 PHE A 385 -10.052 9.907 -8.285 1.00 97.98 C \\\\nATOM 3026 CE2 PHE A 385 -7.959 10.308 -9.432 1.00 97.98 C \\\\nATOM 3027 CZ PHE A 385 -9.358 10.352 -9.416 1.00 97.98 C \\\\nATOM 3028 N ASN A 386 -8.595 11.344 -4.681 1.00 95.89 N \\\\nATOM 3029 CA ASN A 386 -9.868 11.815 -4.134 1.00 95.89 C \\\\nATOM 3030 C ASN A 386 -10.840 12.167 -5.281 1.00 95.89 C \\\\nATOM 3031 CB ASN A 386 -9.582 12.993 -3.183 1.00 95.89 C \\\\nATOM 3032 O ASN A 386 -10.531 12.988 -6.148 1.00 95.89 O \\\\nATOM 3033 CG ASN A 386 -10.836 13.650 -2.638 1.00 95.89 C \\\\nATOM 3034 ND2 ASN A 386 -11.081 13.677 -1.353 1.00 95.89 N \\\\nATOM 3035 OD1 ASN A 386 -11.657 14.142 -3.385 1.00 95.89 O \\\\nATOM 3036 N ASN A 387 -12.028 11.554 -5.262 1.00 94.32 N \\\\nATOM 3037 CA ASN A 387 -13.050 11.721 -6.296 1.00 94.32 C \\\\nATOM 3038 C ASN A 387 -13.654 13.130 -6.338 1.00 94.32 C \\\\nATOM 3039 CB ASN A 387 -14.183 10.698 -6.083 1.00 94.32 C \\\\nATOM 3040 O ASN A 387 -14.024 13.580 -7.415 1.00 94.32 O \\\\nATOM 3041 CG ASN A 387 -13.870 9.277 -6.515 1.00 94.32 C \\\\nATOM 3042 ND2 ASN A 387 -14.802 8.374 -6.338 1.00 94.32 N \\\\nATOM 3043 OD1 ASN A 387 -12.814 8.959 -7.028 1.00 94.32 O \\\\nATOM 3044 N GLN A 388 -13.768 13.834 -5.209 1.00 93.82 N \\\\nATOM 3045 CA GLN A 388 -14.294 15.206 -5.180 1.00 93.82 C \\\\nATOM 3046 C GLN A 388 -13.327 16.188 -5.848 1.00 93.82 C \\\\nATOM 3047 CB GLN A 388 -14.558 15.666 -3.740 1.00 93.82 C \\\\nATOM 3048 O GLN A 388 -13.753 17.058 -6.602 1.00 93.82 O \\\\nATOM 3049 CG GLN A 388 -15.637 14.855 -3.015 1.00 93.82 C \\\\nATOM 3050 CD GLN A 388 -15.860 15.367 -1.596 1.00 93.82 C \\\\nATOM 3051 NE2 GLN A 388 -17.079 15.365 -1.111 1.00 93.82 N \\\\nATOM 3052 OE1 GLN A 388 -14.960 15.786 -0.891 1.00 93.82 O \\\\nATOM 3053 N GLU A 389 -12.024 16.024 -5.615 1.00 94.83 N \\\\nATOM 3054 CA GLU A 389 -10.987 16.821 -6.276 1.00 94.83 C \\\\nATOM 3055 C GLU A 389 -10.980 16.567 -7.786 1.00 94.83 C \\\\nATOM 3056 CB GLU A 389 -9.615 16.480 -5.684 1.00 94.83 C \\\\nATOM 3057 O GLU A 389 -10.916 17.509 -8.573 1.00 94.83 O \\\\nATOM 3058 CG GLU A 389 -9.465 16.962 -4.234 1.00 94.83 C \\\\nATOM 3059 CD GLU A 389 -8.200 16.419 -3.565 1.00 94.83 C \\\\nATOM 3060 OE1 GLU A 389 -8.029 16.604 -2.342 1.00 94.83 O \\\\nATOM 3061 OE2 GLU A 389 -7.391 15.714 -4.210 1.00 94.83 O \\\\nATOM 3062 N PHE A 390 -11.113 15.301 -8.197 1.00 96.24 N \\\\nATOM 3063 CA PHE A 390 -11.250 14.953 -9.609 1.00 96.24 C \\\\nATOM 3064 C PHE A 390 -12.540 15.514 -10.225 1.00 96.24 C \\\\nATOM 3065 CB PHE A 390 -11.166 13.434 -9.773 1.00 96.24 C \\\\nATOM 3066 O PHE A 390 -12.490 16.068 -11.317 1.00 96.24 O \\\\nATOM 3067 CG PHE A 390 -11.298 12.992 -11.217 1.00 96.24 C \\\\nATOM 3068 CD1 PHE A 390 -12.518 12.467 -11.688 1.00 96.24 C \\\\nATOM 3069 CD2 PHE A 390 -10.216 13.152 -12.103 1.00 96.24 C \\\\nATOM 3070 CE1 PHE A 390 -12.650 12.096 -13.038 1.00 96.24 C \\\\nATOM 3071 CE2 PHE A 390 -10.352 12.779 -13.452 1.00 96.24 C \\\\nATOM 3072 CZ PHE A 390 -11.566 12.248 -13.917 1.00 96.24 C \\\\nATOM 3073 N ALA A 391 -13.674 15.437 -9.519 1.00 94.09 N \\\\nATOM 3074 CA ALA A 391 -14.953 15.999 -9.956 1.00 94.09 C \\\\nATOM 3075 C ALA A 391 -14.858 17.504 -10.230 1.00 94.09 C \\\\nATOM 3076 CB ALA A 391 -15.999 15.773 -8.856 1.00 94.09 C \\\\nATOM 3077 O ALA A 391 -15.314 17.984 -11.267 1.00 94.09 O \\\\nATOM 3078 N ALA A 392 -14.256 18.246 -9.295 1.00 94.21 N \\\\nATOM 3079 CA ALA A 392 -14.075 19.686 -9.418 1.00 94.21 C \\\\nATOM 3080 C ALA A 392 -13.184 20.033 -10.617 1.00 94.21 C \\\\nATOM 3081 CB ALA A 392 -13.490 20.214 -8.103 1.00 94.21 C \\\\nATOM 3082 O ALA A 392 -13.516 20.936 -11.383 1.00 94.21 O \\\\nATOM 3083 N LEU A 393 -12.094 19.286 -10.811 1.00 94.52 N \\\\nATOM 3084 CA LEU A 393 -11.209 19.462 -11.958 1.00 94.52 C \\\\nATOM 3085 C LEU A 393 -11.916 19.143 -13.280 1.00 94.52 C \\\\nATOM 3086 CB LEU A 393 -9.968 18.587 -11.751 1.00 94.52 C \\\\nATOM 3087 O LEU A 393 -11.835 19.930 -14.214 1.00 94.52 O \\\\nATOM 3088 CG LEU A 393 -8.927 18.738 -12.870 1.00 94.52 C \\\\nATOM 3089 CD1 LEU A 393 -8.401 20.170 -12.984 1.00 94.52 C \\\\nATOM 3090 CD2 LEU A 393 -7.771 17.797 -12.558 1.00 94.52 C \\\\nATOM 3091 N LEU A 394 -12.662 18.038 -13.344 1.00 94.94 N \\\\nATOM 3092 CA LEU A 394 -13.439 17.651 -14.520 1.00 94.94 C \\\\nATOM 3093 C LEU A 394 -14.450 18.735 -14.906 1.00 94.94 C \\\\nATOM 3094 CB LEU A 394 -14.099 16.288 -14.237 1.00 94.94 C \\\\nATOM 3095 O LEU A 394 -14.493 19.146 -16.063 1.00 94.94 O \\\\nATOM 3096 CG LEU A 394 -14.979 15.742 -15.376 1.00 94.94 C \\\\nATOM 3097 CD1 LEU A 394 -14.211 15.600 -16.687 1.00 94.94 C \\\\nATOM 3098 CD2 LEU A 394 -15.510 14.362 -14.978 1.00 94.94 C \\\\nATOM 3099 N ALA A 395 -15.207 19.256 -13.937 1.00 93.07 N \\\\nATOM 3100 CA ALA A 395 -16.156 20.342 -14.169 1.00 93.07 C \\\\nATOM 3101 C ALA A 395 -15.480 21.632 -14.670 1.00 93.07 C \\\\nATOM 3102 CB ALA A 395 -16.929 20.587 -12.868 1.00 93.07 C \\\\nATOM 3103 O ALA A 395 -16.045 22.343 -15.498 1.00 93.07 O \\\\nATOM 3104 N GLN A 396 -14.266 21.935 -14.201 1.00 93.21 N \\\\nATOM 3105 CA GLN A 396 -13.488 23.081 -14.681 1.00 93.21 C \\\\nATOM 3106 C GLN A 396 -12.965 22.861 -16.107 1.00 93.21 C \\\\nATOM 3107 CB GLN A 396 -12.330 23.364 -13.715 1.00 93.21 C \\\\nATOM 3108 O GLN A 396 -13.097 23.755 -16.943 1.00 93.21 O \\\\nATOM 3109 CG GLN A 396 -12.817 23.965 -12.389 1.00 93.21 C \\\\nATOM 3110 CD GLN A 396 -11.714 24.049 -11.337 1.00 93.21 C \\\\nATOM 3111 NE2 GLN A 396 -12.058 24.325 -10.098 1.00 93.21 N \\\\nATOM 3112 OE1 GLN A 396 -10.531 23.896 -11.587 1.00 93.21 O \\\\nATOM 3113 N SER A 397 -12.420 21.677 -16.400 1.00 93.63 N \\\\nATOM 3114 CA SER A 397 -11.832 21.340 -17.702 1.00 93.63 C \\\\nATOM 3115 C SER A 397 -12.854 21.267 -18.834 1.00 93.63 C \\\\nATOM 3116 CB SER A 397 -11.082 20.010 -17.619 1.00 93.63 C \\\\nATOM 3117 O SER A 397 -12.492 21.547 -19.971 1.00 93.63 O \\\\nATOM 3118 OG SER A 397 -9.968 20.134 -16.755 1.00 93.63 O \\\\nATOM 3119 N VAL A 398 -14.131 20.978 -18.552 1.00 91.77 N \\\\nATOM 3120 CA VAL A 398 -15.205 21.048 -19.564 1.00 91.77 C \\\\nATOM 3121 C VAL A 398 -15.265 22.425 -20.234 1.00 91.77 C \\\\nATOM 3122 CB VAL A 398 -16.559 20.665 -18.938 1.00 91.77 C \\\\nATOM 3123 O VAL A 398 -15.428 22.509 -21.448 1.00 91.77 O \\\\nATOM 3124 CG1 VAL A 398 -17.769 21.034 -19.801 1.00 91.77 C \\\\nATOM 3125 CG2 VAL A 398 -16.616 19.149 -18.736 1.00 91.77 C \\\\nATOM 3126 N ASN A 399 -15.031 23.506 -19.484 1.00 88.71 N \\\\nATOM 3127 CA ASN A 399 -15.034 24.867 -20.034 1.00 88.71 C \\\\nATOM 3128 C ASN A 399 -13.769 25.208 -20.843 1.00 88.71 C \\\\nATOM 3129 CB ASN A 399 -15.237 25.870 -18.890 1.00 88.71 C \\\\nATOM 3130 O ASN A 399 -13.734 26.231 -21.518 1.00 88.71 O \\\\nATOM 3131 CG ASN A 399 -16.513 25.607 -18.116 1.00 88.71 C \\\\nATOM 3132 ND2 ASN A 399 -16.405 25.322 -16.841 1.00 88.71 N \\\\nATOM 3133 OD1 ASN A 399 -17.610 25.615 -18.643 1.00 88.71 O \\\\nATOM 3134 N GLN A 400 -12.726 24.377 -20.767 1.00 90.24 N \\\\nATOM 3135 CA GLN A 400 -11.464 24.554 -21.497 1.00 90.24 C \\\\nATOM 3136 C GLN A 400 -11.454 23.802 -22.840 1.00 90.24 C \\\\nATOM 3137 CB GLN A 400 -10.297 24.102 -20.607 1.00 90.24 C \\\\nATOM 3138 O GLN A 400 -10.539 23.982 -23.641 1.00 90.24 O \\\\nATOM 3139 CG GLN A 400 -10.160 24.910 -19.309 1.00 90.24 C \\\\nATOM 3140 CD GLN A 400 -9.090 24.349 -18.376 1.00 90.24 C \\\\nATOM 3141 NE2 GLN A 400 -8.996 24.853 -17.167 1.00 90.24 N \\\\nATOM 3142 OE1 GLN A 400 -8.341 23.435 -18.680 1.00 90.24 O \\\\nATOM 3143 N GLY A 401 -12.472 22.976 -23.102 1.00 89.27 N \\\\nATOM 3144 CA GLY A 401 -12.641 22.243 -24.353 1.00 89.27 C \\\\nATOM 3145 C GLY A 401 -12.207 20.776 -24.292 1.00 89.27 C \\\\nATOM 3146 O GLY A 401 -11.748 20.264 -23.271 1.00 89.27 O \\\\nATOM 3147 N PHE A 402 -12.382 20.086 -25.421 1.00 90.38 N \\\\nATOM 3148 CA PHE A 402 -12.212 18.635 -25.535 1.00 90.38 C \\\\nATOM 3149 C PHE A 402 -10.825 18.148 -25.092 1.00 90.38 C \\\\nATOM 3150 CB PHE A 402 -12.499 18.227 -26.989 1.00 90.38 C \\\\nATOM 3151 O PHE A 402 -10.730 17.192 -24.327 1.00 90.38 O \\\\nATOM 3152 CG PHE A 402 -12.438 16.732 -27.227 1.00 90.38 C \\\\nATOM 3153 CD1 PHE A 402 -11.204 16.100 -27.479 1.00 90.38 C \\\\nATOM 3154 CD2 PHE A 402 -13.615 15.964 -27.177 1.00 90.38 C \\\\nATOM 3155 CE1 PHE A 402 -11.148 14.707 -27.666 1.00 90.38 C \\\\nATOM 3156 CE2 PHE A 402 -13.560 14.573 -27.372 1.00 90.38 C \\\\nATOM 3157 CZ PHE A 402 -12.327 13.944 -27.616 1.00 90.38 C \\\\nATOM 3158 N GLU A 403 -9.752 18.816 -25.531 1.00 91.17 N \\\\nATOM 3159 CA GLU A 403 -8.376 18.393 -25.238 1.00 91.17 C \\\\nATOM 3160 C GLU A 403 -8.076 18.432 -23.734 1.00 91.17 C \\\\nATOM 3161 CB GLU A 403 -7.395 19.281 -26.026 1.00 91.17 C \\\\nATOM 3162 O GLU A 403 -7.521 17.483 -23.187 1.00 91.17 O \\\\nATOM 3163 CG GLU A 403 -5.925 18.840 -25.911 1.00 91.17 C \\\\nATOM 3164 CD GLU A 403 -5.677 17.399 -26.387 1.00 91.17 C \\\\nATOM 3165 OE1 GLU A 403 -4.748 16.760 -25.836 1.00 91.17 O \\\\nATOM 3166 OE2 GLU A 403 -6.428 16.933 -27.273 1.00 91.17 O \\\\nATOM 3167 N ALA A 404 -8.515 19.483 -23.035 1.00 92.62 N \\\\nATOM 3168 CA ALA A 404 -8.321 19.609 -21.593 1.00 92.62 C \\\\nATOM 3169 C ALA A 404 -9.007 18.472 -20.823 1.00 92.62 C \\\\nATOM 3170 CB ALA A 404 -8.858 20.971 -21.154 1.00 92.62 C \\\\nATOM 3171 O ALA A 404 -8.413 17.896 -19.912 1.00 92.62 O \\\\nATOM 3172 N VAL A 405 -10.231 18.107 -21.221 1.00 93.34 N \\\\nATOM 3173 CA VAL A 405 -10.944 16.953 -20.659 1.00 93.34 C \\\\nATOM 3174 C VAL A 405 -10.209 15.657 -21.007 1.00 93.34 C \\\\nATOM 3175 CB VAL A 405 -12.409 16.916 -21.137 1.00 93.34 C \\\\nATOM 3176 O VAL A 405 -9.949 14.849 -20.123 1.00 93.34 O \\\\nATOM 3177 CG1 VAL A 405 -13.168 15.723 -20.550 1.00 93.34 C \\\\nATOM 3178 CG2 VAL A 405 -13.171 18.174 -20.705 1.00 93.34 C \\\\nATOM 3179 N TYR A 406 -9.798 15.465 -22.260 1.00 92.37 N \\\\nATOM 3180 CA TYR A 406 -9.100 14.254 -22.696 1.00 92.37 C \\\\nATOM 3181 C TYR A 406 -7.802 14.006 -21.904 1.00 92.37 C \\\\nATOM 3182 CB TYR A 406 -8.839 14.353 -24.203 1.00 92.37 C \\\\nATOM 3183 O TYR A 406 -7.530 12.876 -21.483 1.00 92.37 O \\\\nATOM 3184 CG TYR A 406 -8.253 13.085 -24.782 1.00 92.37 C \\\\nATOM 3185 CD1 TYR A 406 -6.866 12.983 -24.999 1.00 92.37 C \\\\nATOM 3186 CD2 TYR A 406 -9.099 12.000 -25.083 1.00 92.37 C \\\\nATOM 3187 CE1 TYR A 406 -6.320 11.791 -25.513 1.00 92.37 C \\\\nATOM 3188 CE2 TYR A 406 -8.557 10.807 -25.597 1.00 92.37 C \\\\nATOM 3189 OH TYR A 406 -6.648 9.555 -26.324 1.00 92.37 O \\\\nATOM 3190 CZ TYR A 406 -7.168 10.702 -25.813 1.00 92.37 C \\\\nATOM 3191 N GLN A 407 -7.043 15.062 -21.594 1.00 92.56 N \\\\nATOM 3192 CA GLN A 407 -5.833 14.987 -20.766 1.00 92.56 C \\\\nATOM 3193 C GLN A 407 -6.097 14.491 -19.332 1.00 92.56 C \\\\nATOM 3194 CB GLN A 407 -5.140 16.361 -20.741 1.00 92.56 C \\\\nATOM 3195 O GLN A 407 -5.215 13.866 -18.729 1.00 92.56 O \\\\nATOM 3196 CG GLN A 407 -4.521 16.759 -22.093 1.00 92.56 C \\\\nATOM 3197 CD GLN A 407 -3.387 15.857 -22.554 1.00 92.56 C \\\\nATOM 3198 NE2 GLN A 407 -3.095 15.834 -23.833 1.00 92.56 N \\\\nATOM 3199 OE1 GLN A 407 -2.752 15.147 -21.784 1.00 92.56 O \\\\nATOM 3200 N LEU A 408 -7.314 14.661 -18.794 1.00 94.48 N \\\\nATOM 3201 CA LEU A 408 -7.694 14.129 -17.477 1.00 94.48 C \\\\nATOM 3202 C LEU A 408 -7.704 12.599 -17.416 1.00 94.48 C \\\\nATOM 3203 CB LEU A 408 -9.060 14.664 -17.020 1.00 94.48 C \\\\nATOM 3204 O LEU A 408 -7.690 12.040 -16.318 1.00 94.48 O \\\\nATOM 3205 CG LEU A 408 -9.156 16.186 -16.858 1.00 94.48 C \\\\nATOM 3206 CD1 LEU A 408 -10.550 16.528 -16.344 1.00 94.48 C \\\\nATOM 3207 CD2 LEU A 408 -8.130 16.720 -15.861 1.00 94.48 C \\\\nATOM 3208 N THR A 409 -7.622 11.906 -18.555 1.00 94.82 N \\\\nATOM 3209 CA THR A 409 -7.381 10.454 -18.586 1.00 94.82 C \\\\nATOM 3210 C THR A 409 -6.137 10.100 -17.766 1.00 94.82 C \\\\nATOM 3211 CB THR A 409 -7.208 9.953 -20.028 1.00 94.82 C \\\\nATOM 3212 O THR A 409 -6.144 9.133 -17.007 1.00 94.82 O \\\\nATOM 3213 CG2 THR A 409 -7.149 8.427 -20.100 1.00 94.82 C \\\\nATOM 3214 OG1 THR A 409 -8.301 10.347 -20.817 1.00 94.82 O \\\\nATOM 3215 N ARG A 410 -5.094 10.946 -17.816 1.00 93.13 N \\\\nATOM 3216 CA ARG A 410 -3.854 10.766 -17.042 1.00 93.13 C \\\\nATOM 3217 C ARG A 410 -4.078 10.857 -15.534 1.00 93.13 C \\\\nATOM 3218 CB ARG A 410 -2.806 11.807 -17.467 1.00 93.13 C \\\\nATOM 3219 O ARG A 410 -3.379 10.185 -14.784 1.00 93.13 O \\\\nATOM 3220 CG ARG A 410 -2.404 11.694 -18.945 1.00 93.13 C \\\\nATOM 3221 CD ARG A 410 -1.350 12.752 -19.299 1.00 93.13 C \\\\nATOM 3222 NE ARG A 410 -0.998 12.695 -20.728 1.00 93.13 N \\\\nATOM 3223 NH1 ARG A 410 0.238 14.644 -20.846 1.00 93.13 N \\\\nATOM 3224 NH2 ARG A 410 -0.291 13.571 -22.708 1.00 93.13 N \\\\nATOM 3225 CZ ARG A 410 -0.356 13.632 -21.409 1.00 93.13 C \\\\nATOM 3226 N MET A 411 -5.054 11.647 -15.081 1.00 94.91 N \\\\nATOM 3227 CA MET A 411 -5.395 11.753 -13.657 1.00 94.91 C \\\\nATOM 3228 C MET A 411 -5.948 10.439 -13.107 1.00 94.91 C \\\\nATOM 3229 CB MET A 411 -6.416 12.876 -13.415 1.00 94.91 C \\\\nATOM 3230 O MET A 411 -5.793 10.166 -11.920 1.00 94.91 O \\\\nATOM 3231 CG MET A 411 -5.905 14.262 -13.817 1.00 94.91 C \\\\nATOM 3232 SD MET A 411 -4.534 14.885 -12.816 1.00 94.91 S \\\\nATOM 3233 CE MET A 411 -5.412 15.315 -11.297 1.00 94.91 C \\\\nATOM 3234 N CYS A 412 -6.558 9.620 -13.965 1.00 96.87 N \\\\nATOM 3235 CA CYS A 412 -7.174 8.354 -13.588 1.00 96.87 C \\\\nATOM 3236 C CYS A 412 -6.182 7.176 -13.543 1.00 96.87 C \\\\nATOM 3237 CB CYS A 412 -8.323 8.061 -14.551 1.00 96.87 C \\\\nATOM 3238 O CYS A 412 -6.571 6.071 -13.153 1.00 96.87 O \\\\nATOM 3239 SG CYS A 412 -9.484 9.454 -14.693 1.00 96.87 S \\\\nATOM 3240 N THR A 413 -4.917 7.407 -13.918 1.00 97.46 N \\\\nATOM 3241 CA THR A 413 -3.845 6.408 -13.909 1.00 97.46 C \\\\nATOM 3242 C THR A 413 -2.819 6.731 -12.826 1.00 97.46 C \\\\nATOM 3243 CB THR A 413 -3.174 6.281 -15.284 1.00 97.46 C \\\\nATOM 3244 O THR A 413 -2.224 7.807 -12.805 1.00 97.46 O \\\\nATOM 3245 CG2 THR A 413 -2.057 5.237 -15.300 1.00 97.46 C \\\\nATOM 3246 OG1 THR A 413 -4.123 5.875 -16.241 1.00 97.46 O \\\\nATOM 3247 N ILE A 414 -2.566 5.773 -11.934 1.00 98.40 N \\\\nATOM 3248 CA ILE A 414 -1.571 5.888 -10.861 1.00 98.40 C \\\\nATOM 3249 C ILE A 414 -0.518 4.805 -11.048 1.00 98.40 C \\\\nATOM 3250 CB ILE A 414 -2.229 5.818 -9.466 1.00 98.40 C \\\\nATOM 3251 O ILE A 414 -0.847 3.631 -11.200 1.00 98.40 O \\\\nATOM 3252 CG1 ILE A 414 -3.288 6.932 -9.308 1.00 98.40 C \\\\nATOM 3253 CG2 ILE A 414 -1.145 5.904 -8.372 1.00 98.40 C \\\\nATOM 3254 CD1 ILE A 414 -4.102 6.848 -8.014 1.00 98.40 C \\\\nATOM 3255 N ARG A 415 0.762 5.174 -10.987 1.00 98.53 N \\\\nATOM 3256 CA ARG A 415 1.872 4.219 -11.121 1.00 98.53 C \\\\nATOM 3257 C ARG A 415 2.588 4.041 -9.800 1.00 98.53 C \\\\nATOM 3258 CB ARG A 415 2.820 4.644 -12.244 1.00 98.53 C \\\\nATOM 3259 O ARG A 415 2.842 5.023 -9.102 1.00 98.53 O \\\\nATOM 3260 CG ARG A 415 2.070 4.671 -13.580 1.00 98.53 C \\\\nATOM 3261 CD ARG A 415 3.027 4.946 -14.731 1.00 98.53 C \\\\nATOM 3262 NE ARG A 415 2.281 4.998 -15.992 1.00 98.53 N \\\\nATOM 3263 NH1 ARG A 415 2.570 7.221 -16.554 1.00 98.53 N \\\\nATOM 3264 NH2 ARG A 415 1.353 5.820 -17.837 1.00 98.53 N \\\\nATOM 3265 CZ ARG A 415 2.087 6.027 -16.786 1.00 98.53 C \\\\nATOM 3266 N MET A 416 2.925 2.800 -9.456 1.00 98.54 N \\\\nATOM 3267 CA MET A 416 3.635 2.491 -8.216 1.00 98.54 C \\\\nATOM 3268 C MET A 416 4.779 1.514 -8.450 1.00 98.54 C \\\\nATOM 3269 CB MET A 416 2.700 1.961 -7.119 1.00 98.54 C \\\\nATOM 3270 O MET A 416 4.558 0.423 -8.959 1.00 98.54 O \\\\nATOM 3271 CG MET A 416 1.465 2.837 -6.929 1.00 98.54 C \\\\nATOM 3272 SD MET A 416 0.417 2.357 -5.534 1.00 98.54 S \\\\nATOM 3273 CE MET A 416 -1.180 2.527 -6.374 1.00 98.54 C \\\\nATOM 3274 N SER A 417 5.989 1.874 -8.031 1.00 98.68 N \\\\nATOM 3275 CA SER A 417 7.156 0.987 -8.055 1.00 98.68 C \\\\nATOM 3276 C SER A 417 7.431 0.411 -6.673 1.00 98.68 C \\\\nATOM 3277 CB SER A 417 8.388 1.709 -8.591 1.00 98.68 C \\\\nATOM 3278 O SER A 417 7.337 1.110 -5.659 1.00 98.68 O \\\\nATOM 3279 OG SER A 417 9.519 0.869 -8.532 1.00 98.68 O \\\\nATOM 3280 N PHE A 418 7.828 -0.858 -6.638 1.00 98.70 N \\\\nATOM 3281 CA PHE A 418 8.259 -1.538 -5.425 1.00 98.70 C \\\\nATOM 3282 C PHE A 418 9.772 -1.417 -5.254 1.00 98.70 C \\\\nATOM 3283 CB PHE A 418 7.837 -3.009 -5.470 1.00 98.70 C \\\\nATOM 3284 O PHE A 418 10.532 -1.666 -6.191 1.00 98.70 O \\\\nATOM 3285 CG PHE A 418 6.342 -3.225 -5.552 1.00 98.70 C \\\\nATOM 3286 CD1 PHE A 418 5.569 -3.241 -4.376 1.00 98.70 C \\\\nATOM 3287 CD2 PHE A 418 5.721 -3.406 -6.801 1.00 98.70 C \\\\nATOM 3288 CE1 PHE A 418 4.181 -3.446 -4.448 1.00 98.70 C \\\\nATOM 3289 CE2 PHE A 418 4.333 -3.607 -6.870 1.00 98.70 C \\\\nATOM 3290 CZ PHE A 418 3.561 -3.627 -5.696 1.00 98.70 C \\\\nATOM 3291 N VAL A 419 10.227 -1.120 -4.030 1.00 98.25 N \\\\nATOM 3292 CA VAL A 419 11.637 -1.131 -3.584 1.00 98.25 C \\\\nATOM 3293 C VAL A 419 12.523 -0.048 -4.215 1.00 98.25 C \\\\nATOM 3294 CB VAL A 419 12.276 -2.522 -3.799 1.00 98.25 C \\\\nATOM 3295 O VAL A 419 13.370 0.525 -3.529 1.00 98.25 O \\\\nATOM 3296 CG1 VAL A 419 13.640 -2.667 -3.112 1.00 98.25 C \\\\nATOM 3297 CG2 VAL A 419 11.402 -3.700 -3.340 1.00 98.25 C \\\\nATOM 3298 N LYS A 420 12.376 0.248 -5.511 1.00 97.93 N \\\\nATOM 3299 CA LYS A 420 13.226 1.176 -6.269 1.00 97.93 C \\\\nATOM 3300 C LYS A 420 12.432 2.405 -6.714 1.00 97.93 C \\\\nATOM 3301 CB LYS A 420 13.845 0.453 -7.483 1.00 97.93 C \\\\nATOM 3302 O LYS A 420 11.447 2.270 -7.432 1.00 97.93 O \\\\nATOM 3303 CG LYS A 420 14.640 -0.827 -7.164 1.00 97.93 C \\\\nATOM 3304 CD LYS A 420 15.786 -0.620 -6.162 1.00 97.93 C \\\\nATOM 3305 CE LYS A 420 16.542 -1.940 -5.960 1.00 97.93 C \\\\nATOM 3306 NZ LYS A 420 17.556 -1.843 -4.877 1.00 97.93 N \\\\nATOM 3307 N GLY A 421 12.905 3.593 -6.345 1.00 96.38 N \\\\nATOM 3308 CA GLY A 421 12.352 4.863 -6.819 1.00 96.38 C \\\\nATOM 3309 C GLY A 421 12.787 5.220 -8.239 1.00 96.38 C \\\\nATOM 3310 O GLY A 421 13.769 4.675 -8.761 1.00 96.38 O \\\\nATOM 3311 N TRP A 422 12.042 6.146 -8.838 1.00 98.03 N \\\\nATOM 3312 CA TRP A 422 12.339 6.792 -10.116 1.00 98.03 C \\\\nATOM 3313 C TRP A 422 11.929 8.271 -10.069 1.00 98.03 C \\\\nATOM 3314 CB TRP A 422 11.632 6.065 -11.270 1.00 98.03 C \\\\nATOM 3315 O TRP A 422 11.267 8.695 -9.122 1.00 98.03 O \\\\nATOM 3316 CG TRP A 422 10.193 6.426 -11.478 1.00 98.03 C \\\\nATOM 3317 CD1 TRP A 422 9.735 7.303 -12.401 1.00 98.03 C \\\\nATOM 3318 CD2 TRP A 422 9.016 5.985 -10.737 1.00 98.03 C \\\\nATOM 3319 CE2 TRP A 422 7.867 6.612 -11.307 1.00 98.03 C \\\\nATOM 3320 CE3 TRP A 422 8.800 5.122 -9.642 1.00 98.03 C \\\\nATOM 3321 NE1 TRP A 422 8.363 7.409 -12.311 1.00 98.03 N \\\\nATOM 3322 CH2 TRP A 422 6.387 5.528 -9.740 1.00 98.03 C \\\\nATOM 3323 CZ2 TRP A 422 6.571 6.373 -10.842 1.00 98.03 C \\\\nATOM 3324 CZ3 TRP A 422 7.500 4.913 -9.146 1.00 98.03 C \\\\nATOM 3325 N GLY A 423 12.309 9.041 -11.083 1.00 94.75 N \\\\nATOM 3326 CA GLY A 423 12.044 10.475 -11.190 1.00 94.75 C \\\\nATOM 3327 C GLY A 423 13.250 11.323 -10.786 1.00 94.75 C \\\\nATOM 3328 O GLY A 423 14.344 10.795 -10.600 1.00 94.75 O \\\\nATOM 3329 N ALA A 424 13.032 12.634 -10.641 1.00 90.85 N \\\\nATOM 3330 CA ALA A 424 14.086 13.644 -10.487 1.00 90.85 C \\\\nATOM 3331 C ALA A 424 15.119 13.325 -9.386 1.00 90.85 C \\\\nATOM 3332 CB ALA A 424 13.394 14.987 -10.215 1.00 90.85 C \\\\nATOM 3333 O ALA A 424 16.310 13.545 -9.571 1.00 90.85 O \\\\nATOM 3334 N GLU A 425 14.673 12.721 -8.282 1.00 88.72 N \\\\nATOM 3335 CA GLU A 425 15.503 12.405 -7.109 1.00 88.72 C \\\\nATOM 3336 C GLU A 425 16.249 11.058 -7.203 1.00 88.72 C \\\\nATOM 3337 CB GLU A 425 14.613 12.434 -5.855 1.00 88.72 C \\\\nATOM 3338 O GLU A 425 16.893 10.619 -6.248 1.00 88.72 O \\\\nATOM 3339 CG GLU A 425 13.885 13.769 -5.639 1.00 88.72 C \\\\nATOM 3340 CD GLU A 425 14.850 14.961 -5.596 1.00 88.72 C \\\\nATOM 3341 OE1 GLU A 425 14.500 15.996 -6.201 1.00 88.72 O \\\\nATOM 3342 OE2 GLU A 425 15.920 14.809 -4.965 1.00 88.72 O \\\\nATOM 3343 N TYR A 426 16.141 10.341 -8.325 1.00 94.62 N \\\\nATOM 3344 CA TYR A 426 16.680 8.990 -8.470 1.00 94.62 C \\\\nATOM 3345 C TYR A 426 17.466 8.829 -9.770 1.00 94.62 C \\\\nATOM 3346 CB TYR A 426 15.548 7.953 -8.380 1.00 94.62 C \\\\nATOM 3347 O TYR A 426 17.192 9.450 -10.787 1.00 94.62 O \\\\nATOM 3348 CG TYR A 426 14.758 7.996 -7.084 1.00 94.62 C \\\\nATOM 3349 CD1 TYR A 426 15.210 7.314 -5.935 1.00 94.62 C \\\\nATOM 3350 CD2 TYR A 426 13.601 8.790 -7.013 1.00 94.62 C \\\\nATOM 3351 CE1 TYR A 426 14.518 7.457 -4.715 1.00 94.62 C \\\\nATOM 3352 CE2 TYR A 426 12.900 8.928 -5.804 1.00 94.62 C \\\\nATOM 3353 OH TYR A 426 12.775 8.538 -3.454 1.00 94.62 O \\\\nATOM 3354 CZ TYR A 426 13.380 8.292 -4.645 1.00 94.62 C \\\\nATOM 3355 N ARG A 427 18.413 7.880 -9.782 1.00 94.90 N \\\\nATOM 3356 CA ARG A 427 19.152 7.509 -11.005 1.00 94.90 C \\\\nATOM 3357 C ARG A 427 18.225 7.072 -12.151 1.00 94.90 C \\\\nATOM 3358 CB ARG A 427 20.176 6.414 -10.660 1.00 94.90 C \\\\nATOM 3359 O ARG A 427 18.559 7.251 -13.317 1.00 94.90 O \\\\nATOM 3360 CG ARG A 427 21.004 5.978 -11.879 1.00 94.90 C \\\\nATOM 3361 CD ARG A 427 22.040 4.915 -11.509 1.00 94.90 C \\\\nATOM 3362 NE ARG A 427 22.699 4.393 -12.720 1.00 94.90 N \\\\nATOM 3363 NH1 ARG A 427 23.904 2.705 -11.734 1.00 94.90 N \\\\nATOM 3364 NH2 ARG A 427 24.039 3.017 -13.941 1.00 94.90 N \\\\nATOM 3365 CZ ARG A 427 23.540 3.376 -12.793 1.00 94.90 C \\\\nATOM 3366 N ARG A 428 17.099 6.434 -11.823 1.00 96.14 N \\\\nATOM 3367 CA ARG A 428 16.100 5.985 -12.799 1.00 96.14 C \\\\nATOM 3368 C ARG A 428 15.198 7.158 -13.132 1.00 96.14 C \\\\nATOM 3369 CB ARG A 428 15.268 4.838 -12.216 1.00 96.14 C \\\\nATOM 3370 O ARG A 428 14.451 7.585 -12.263 1.00 96.14 O \\\\nATOM 3371 CG ARG A 428 16.093 3.561 -12.091 1.00 96.14 C \\\\nATOM 3372 CD ARG A 428 15.265 2.482 -11.392 1.00 96.14 C \\\\nATOM 3373 NE ARG A 428 16.005 1.210 -11.355 1.00 96.14 N \\\\nATOM 3374 NH1 ARG A 428 17.371 1.723 -9.587 1.00 96.14 N \\\\nATOM 3375 NH2 ARG A 428 17.678 -0.190 -10.713 1.00 96.14 N \\\\nATOM 3376 CZ ARG A 428 17.010 0.917 -10.552 1.00 96.14 C \\\\nATOM 3377 N GLN A 429 15.240 7.633 -14.370 1.00 95.89 N \\\\nATOM 3378 CA GLN A 429 14.371 8.733 -14.772 1.00 95.89 C \\\\nATOM 3379 C GLN A 429 12.954 8.245 -15.040 1.00 95.89 C \\\\nATOM 3380 CB GLN A 429 14.980 9.512 -15.947 1.00 95.89 C \\\\nATOM 3381 O GLN A 429 12.033 8.853 -14.522 1.00 95.89 O \\\\nATOM 3382 CG GLN A 429 16.301 10.202 -15.553 1.00 95.89 C \\\\nATOM 3383 CD GLN A 429 16.155 11.065 -14.298 1.00 95.89 C \\\\nATOM 3384 NE2 GLN A 429 17.031 10.926 -13.331 1.00 95.89 N \\\\nATOM 3385 OE1 GLN A 429 15.202 11.803 -14.129 1.00 95.89 O \\\\nATOM 3386 N THR A 430 12.769 7.111 -15.726 1.00 96.48 N \\\\nATOM 3387 CA THR A 430 11.447 6.572 -16.089 1.00 96.48 C \\\\nATOM 3388 C THR A 430 10.968 5.455 -15.162 1.00 96.48 C \\\\nATOM 3389 CB THR A 430 11.421 6.056 -17.537 1.00 96.48 C \\\\nATOM 3390 O THR A 430 11.773 4.695 -14.610 1.00 96.48 O \\\\nATOM 3391 CG2 THR A 430 11.843 7.080 -18.590 1.00 96.48 C \\\\nATOM 3392 OG1 THR A 430 12.267 4.932 -17.662 1.00 96.48 O \\\\nATOM 3393 N VAL A 431 9.646 5.283 -15.053 1.00 97.27 N \\\\nATOM 3394 CA VAL A 431 9.054 4.138 -14.332 1.00 97.27 C \\\\nATOM 3395 C VAL A 431 9.428 2.805 -14.989 1.00 97.27 C \\\\nATOM 3396 CB VAL A 431 7.529 4.293 -14.205 1.00 97.27 C \\\\nATOM 3397 O VAL A 431 9.712 1.830 -14.299 1.00 97.27 O \\\\nATOM 3398 CG1 VAL A 431 6.798 4.130 -15.543 1.00 97.27 C \\\\nATOM 3399 CG2 VAL A 431 6.972 3.310 -13.171 1.00 97.27 C \\\\nATOM 3400 N THR A 432 9.565 2.786 -16.317 1.00 97.83 N \\\\nATOM 3401 CA THR A 432 9.991 1.622 -17.112 1.00 97.83 C \\\\nATOM 3402 C THR A 432 11.432 1.181 -16.834 1.00 97.83 C \\\\nATOM 3403 CB THR A 432 9.828 1.917 -18.611 1.00 97.83 C \\\\nATOM 3404 O THR A 432 11.830 0.084 -17.210 1.00 97.83 O \\\\nATOM 3405 CG2 THR A 432 8.359 2.070 -19.004 1.00 97.83 C \\\\nATOM 3406 OG1 THR A 432 10.470 3.129 -18.958 1.00 97.83 O \\\\nATOM 3407 N SER A 433 12.220 1.998 -16.126 1.00 97.46 N \\\\nATOM 3408 CA SER A 433 13.549 1.621 -15.624 1.00 97.46 C \\\\nATOM 3409 C SER A 433 13.496 0.910 -14.263 1.00 97.46 C \\\\nATOM 3410 CB SER A 433 14.424 2.869 -15.505 1.00 97.46 C \\\\nATOM 3411 O SER A 433 14.527 0.454 -13.744 1.00 97.46 O \\\\nATOM 3412 OG SER A 433 14.595 3.524 -16.742 1.00 97.46 O \\\\nATOM 3413 N THR A 434 12.325 0.861 -13.621 1.00 98.11 N \\\\nATOM 3414 CA THR A 434 12.142 0.204 -12.325 1.00 98.11 C \\\\nATOM 3415 C THR A 434 11.928 -1.301 -12.509 1.00 98.11 C \\\\nATOM 3416 CB THR A 434 11.031 0.812 -11.463 1.00 98.11 C \\\\nATOM 3417 O THR A 434 11.259 -1.723 -13.452 1.00 98.11 O \\\\nATOM 3418 CG2 THR A 434 11.186 2.317 -11.262 1.00 98.11 C \\\\nATOM 3419 OG1 THR A 434 9.764 0.546 -11.980 1.00 98.11 O \\\\nATOM 3420 N PRO A 435 12.504 -2.154 -11.642 1.00 98.30 N \\\\nATOM 3421 CA PRO A 435 12.450 -3.596 -11.871 1.00 98.30 C \\\\nATOM 3422 C PRO A 435 11.050 -4.194 -11.694 1.00 98.30 C \\\\nATOM 3423 CB PRO A 435 13.442 -4.209 -10.878 1.00 98.30 C \\\\nATOM 3424 O PRO A 435 10.746 -5.203 -12.319 1.00 98.30 O \\\\nATOM 3425 CG PRO A 435 14.335 -3.047 -10.462 1.00 98.30 C \\\\nATOM 3426 CD PRO A 435 13.396 -1.854 -10.532 1.00 98.30 C \\\\nATOM 3427 N CYS A 436 10.221 -3.614 -10.823 1.00 98.65 N \\\\nATOM 3428 CA CYS A 436 8.884 -4.108 -10.502 1.00 98.65 C \\\\nATOM 3429 C CYS A 436 7.965 -2.926 -10.214 1.00 98.65 C \\\\nATOM 3430 CB CYS A 436 8.944 -5.000 -9.249 1.00 98.65 C \\\\nATOM 3431 O CYS A 436 8.176 -2.221 -9.224 1.00 98.65 O \\\\nATOM 3432 SG CYS A 436 10.042 -6.419 -9.493 1.00 98.65 S \\\\nATOM 3433 N TRP A 437 6.930 -2.745 -11.023 1.00 98.76 N \\\\nATOM 3434 CA TRP A 437 5.951 -1.685 -10.817 1.00 98.76 C \\\\nATOM 3435 C TRP A 437 4.570 -2.099 -11.314 1.00 98.76 C \\\\nATOM 3436 CB TRP A 437 6.443 -0.390 -11.475 1.00 98.76 C \\\\nATOM 3437 O TRP A 437 4.419 -3.065 -12.058 1.00 98.76 O \\\\nATOM 3438 CG TRP A 437 6.614 -0.447 -12.954 1.00 98.76 C \\\\nATOM 3439 CD1 TRP A 437 7.657 -1.001 -13.607 1.00 98.76 C \\\\nATOM 3440 CD2 TRP A 437 5.717 0.067 -13.983 1.00 98.76 C \\\\nATOM 3441 CE2 TRP A 437 6.302 -0.203 -15.253 1.00 98.76 C \\\\nATOM 3442 CE3 TRP A 437 4.477 0.739 -13.970 1.00 98.76 C \\\\nATOM 3443 NE1 TRP A 437 7.475 -0.852 -14.960 1.00 98.76 N \\\\nATOM 3444 CH2 TRP A 437 4.433 0.768 -16.408 1.00 98.76 C \\\\nATOM 3445 CZ2 TRP A 437 5.676 0.125 -16.457 1.00 98.76 C \\\\nATOM 3446 CZ3 TRP A 437 3.846 1.096 -15.175 1.00 98.76 C \\\\nATOM 3447 N ILE A 438 3.554 -1.388 -10.843 1.00 98.75 N \\\\nATOM 3448 CA ILE A 438 2.160 -1.576 -11.224 1.00 98.75 C \\\\nATOM 3449 C ILE A 438 1.571 -0.277 -11.759 1.00 98.75 C \\\\nATOM 3450 CB ILE A 438 1.303 -2.146 -10.072 1.00 98.75 C \\\\nATOM 3451 O ILE A 438 1.939 0.818 -11.324 1.00 98.75 O \\\\nATOM 3452 CG1 ILE A 438 1.413 -1.301 -8.783 1.00 98.75 C \\\\nATOM 3453 CG2 ILE A 438 1.664 -3.623 -9.848 1.00 98.75 C \\\\nATOM 3454 CD1 ILE A 438 0.412 -1.684 -7.687 1.00 98.75 C \\\\nATOM 3455 N GLU A 439 0.626 -0.425 -12.674 1.00 98.66 N \\\\nATOM 3456 CA GLU A 439 -0.226 0.638 -13.185 1.00 98.66 C \\\\nATOM 3457 C GLU A 439 -1.659 0.385 -12.722 1.00 98.66 C \\\\nATOM 3458 CB GLU A 439 -0.113 0.684 -14.711 1.00 98.66 C \\\\nATOM 3459 O GLU A 439 -2.210 -0.693 -12.943 1.00 98.66 O \\\\nATOM 3460 CG GLU A 439 -0.773 1.930 -15.307 1.00 98.66 C \\\\nATOM 3461 CD GLU A 439 -0.329 2.117 -16.764 1.00 98.66 C \\\\nATOM 3462 OE1 GLU A 439 -0.586 1.190 -17.567 1.00 98.66 O \\\\nATOM 3463 OE2 GLU A 439 0.372 3.136 -17.029 1.00 98.66 O \\\\nATOM 3464 N LEU A 440 -2.231 1.368 -12.034 1.00 98.22 N \\\\nATOM 3465 CA LEU A 440 -3.578 1.347 -11.491 1.00 98.22 C \\\\nATOM 3466 C LEU A 440 -4.466 2.258 -12.334 1.00 98.22 C \\\\nATOM 3467 CB LEU A 440 -3.521 1.826 -10.023 1.00 98.22 C \\\\nATOM 3468 O LEU A 440 -4.170 3.444 -12.452 1.00 98.22 O \\\\nATOM 3469 CG LEU A 440 -4.725 1.370 -9.189 1.00 98.22 C \\\\nATOM 3470 CD1 LEU A 440 -4.507 -0.084 -8.800 1.00 98.22 C \\\\nATOM 3471 CD2 LEU A 440 -4.859 2.179 -7.899 1.00 98.22 C \\\\nATOM 3472 N HIS A 441 -5.560 1.729 -12.870 1.00 98.13 N \\\\nATOM 3473 CA HIS A 441 -6.609 2.516 -13.522 1.00 98.13 C \\\\nATOM 3474 C HIS A 441 -7.832 2.593 -12.619 1.00 98.13 C \\\\nATOM 3475 CB HIS A 441 -6.971 1.905 -14.878 1.00 98.13 C \\\\nATOM 3476 O HIS A 441 -8.337 1.558 -12.183 1.00 98.13 O \\\\nATOM 3477 CG HIS A 441 -5.885 1.987 -15.917 1.00 98.13 C \\\\nATOM 3478 CD2 HIS A 441 -4.763 2.768 -15.870 1.00 98.13 C \\\\nATOM 3479 ND1 HIS A 441 -5.880 1.348 -17.135 1.00 98.13 N \\\\nATOM 3480 CE1 HIS A 441 -4.779 1.739 -17.802 1.00 98.13 C \\\\nATOM 3481 NE2 HIS A 441 -4.070 2.613 -17.069 1.00 98.13 N \\\\nATOM 3482 N LEU A 442 -8.298 3.808 -12.333 1.00 97.65 N \\\\nATOM 3483 CA LEU A 442 -9.493 4.052 -11.528 1.00 97.65 C \\\\nATOM 3484 C LEU A 442 -10.723 4.098 -12.435 1.00 97.65 C \\\\nATOM 3485 CB LEU A 442 -9.317 5.340 -10.712 1.00 97.65 C \\\\nATOM 3486 O LEU A 442 -10.966 5.081 -13.135 1.00 97.65 O \\\\nATOM 3487 CG LEU A 442 -8.113 5.327 -9.756 1.00 97.65 C \\\\nATOM 3488 CD1 LEU A 442 -8.076 6.651 -9.009 1.00 97.65 C \\\\nATOM 3489 CD2 LEU A 442 -8.185 4.200 -8.722 1.00 97.65 C \\\\nATOM 3490 N ASN A 443 -11.505 3.022 -12.414 1.00 96.77 N \\\\nATOM 3491 CA ASN A 443 -12.575 2.797 -13.384 1.00 96.77 C \\\\nATOM 3492 C ASN A 443 -13.730 3.790 -13.230 1.00 96.77 C \\\\nATOM 3493 CB ASN A 443 -13.079 1.359 -13.224 1.00 96.77 C \\\\nATOM 3494 O ASN A 443 -14.340 4.164 -14.223 1.00 96.77 O \\\\nATOM 3495 CG ASN A 443 -12.053 0.308 -13.601 1.00 96.77 C \\\\nATOM 3496 ND2 ASN A 443 -12.176 -0.876 -13.059 1.00 96.77 N \\\\nATOM 3497 OD1 ASN A 443 -11.132 0.524 -14.365 1.00 96.77 O \\\\nATOM 3498 N GLY A 444 -14.029 4.226 -12.003 1.00 94.54 N \\\\nATOM 3499 CA GLY A 444 -15.098 5.191 -11.745 1.00 94.54 C \\\\nATOM 3500 C GLY A 444 -14.801 6.553 -12.378 1.00 94.54 C \\\\nATOM 3501 O GLY A 444 -15.563 7.000 -13.235 1.00 94.54 O \\\\nATOM 3502 N PRO A 445 -13.667 7.192 -12.030 1.00 95.57 N \\\\nATOM 3503 CA PRO A 445 -13.183 8.395 -12.703 1.00 95.57 C \\\\nATOM 3504 C PRO A 445 -13.102 8.266 -14.232 1.00 95.57 C \\\\nATOM 3505 CB PRO A 445 -11.812 8.667 -12.076 1.00 95.57 C \\\\nATOM 3506 O PRO A 445 -13.582 9.157 -14.930 1.00 95.57 O \\\\nATOM 3507 CG PRO A 445 -11.990 8.153 -10.650 1.00 95.57 C \\\\nATOM 3508 CD PRO A 445 -12.852 6.911 -10.854 1.00 95.57 C \\\\nATOM 3509 N LEU A 446 -12.584 7.146 -14.758 1.00 96.12 N \\\\nATOM 3510 CA LEU A 446 -12.530 6.893 -16.207 1.00 96.12 C \\\\nATOM 3511 C LEU A 446 -13.920 6.832 -16.847 1.00 96.12 C \\\\nATOM 3512 CB LEU A 446 -11.786 5.576 -16.497 1.00 96.12 C \\\\nATOM 3513 O LEU A 446 -14.143 7.458 -17.876 1.00 96.12 O \\\\nATOM 3514 CG LEU A 446 -10.261 5.663 -16.366 1.00 96.12 C \\\\nATOM 3515 CD1 LEU A 446 -9.644 4.269 -16.456 1.00 96.12 C \\\\nATOM 3516 CD2 LEU A 446 -9.629 6.538 -17.453 1.00 96.12 C \\\\nATOM 3517 N GLN A 447 -14.867 6.114 -16.239 1.00 93.99 N \\\\nATOM 3518 CA GLN A 447 -16.236 6.022 -16.746 1.00 93.99 C \\\\nATOM 3519 C GLN A 447 -16.928 7.388 -16.734 1.00 93.99 C \\\\nATOM 3520 CB GLN A 447 -17.025 5.007 -15.900 1.00 93.99 C \\\\nATOM 3521 O GLN A 447 -17.694 7.710 -17.641 1.00 93.99 O \\\\nATOM 3522 CG GLN A 447 -18.453 4.827 -16.434 1.00 93.99 C \\\\nATOM 3523 CD GLN A 447 -19.274 3.840 -15.619 1.00 93.99 C \\\\nATOM 3524 NE2 GLN A 447 -19.847 2.835 -16.240 1.00 93.99 N \\\\nATOM 3525 OE1 GLN A 447 -19.488 3.984 -14.428 1.00 93.99 O \\\\nATOM 3526 N TRP A 448 -16.685 8.201 -15.705 1.00 93.61 N \\\\nATOM 3527 CA TRP A 448 -17.250 9.544 -15.649 1.00 93.61 C \\\\nATOM 3528 C TRP A 448 -16.668 10.445 -16.736 1.00 93.61 C \\\\nATOM 3529 CB TRP A 448 -17.020 10.139 -14.266 1.00 93.61 C \\\\nATOM 3530 O TRP A 448 -17.416 11.158 -17.403 1.00 93.61 O \\\\nATOM 3531 CG TRP A 448 -17.873 11.319 -13.917 1.00 93.61 C \\\\nATOM 3532 CD1 TRP A 448 -18.899 11.839 -14.637 1.00 93.61 C \\\\nATOM 3533 CD2 TRP A 448 -17.793 12.127 -12.714 1.00 93.61 C \\\\nATOM 3534 CE2 TRP A 448 -18.872 13.057 -12.721 1.00 93.61 C \\\\nATOM 3535 CE3 TRP A 448 -16.926 12.138 -11.604 1.00 93.61 C \\\\nATOM 3536 NE1 TRP A 448 -19.496 12.864 -13.931 1.00 93.61 N \\\\nATOM 3537 CH2 TRP A 448 -18.250 13.892 -10.548 1.00 93.61 C \\\\nATOM 3538 CZ2 TRP A 448 -19.116 13.916 -11.649 1.00 93.61 C \\\\nATOM 3539 CZ3 TRP A 448 -17.154 13.009 -10.530 1.00 93.61 C \\\\nATOM 3540 N LEU A 449 -15.354 10.358 -16.948 1.00 94.28 N \\\\nATOM 3541 CA LEU A 449 -14.655 11.076 -18.003 1.00 94.28 C \\\\nATOM 3542 C LEU A 449 -15.173 10.695 -19.397 1.00 94.28 C \\\\nATOM 3543 CB LEU A 449 -13.153 10.779 -17.862 1.00 94.28 C \\\\nATOM 3544 O LEU A 449 -15.466 11.579 -20.195 1.00 94.28 O \\\\nATOM 3545 CG LEU A 449 -12.289 11.610 -18.815 1.00 94.28 C \\\\nATOM 3546 CD1 LEU A 449 -12.347 13.079 -18.418 1.00 94.28 C \\\\nATOM 3547 CD2 LEU A 449 -10.841 11.143 -18.742 1.00 94.28 C \\\\nATOM 3548 N ASP A 450 -15.347 9.401 -19.664 1.00 92.60 N \\\\nATOM 3549 CA ASP A 450 -15.885 8.874 -20.924 1.00 92.60 C \\\\nATOM 3550 C ASP A 450 -17.291 9.424 -21.227 1.00 92.60 C \\\\nATOM 3551 CB ASP A 450 -15.886 7.343 -20.822 1.00 92.60 C \\\\nATOM 3552 O ASP A 450 -17.558 9.945 -22.313 1.00 92.60 O \\\\nATOM 3553 CG ASP A 450 -16.420 6.688 -22.093 1.00 92.60 C \\\\nATOM 3554 OD1 ASP A 450 -15.698 6.749 -23.110 1.00 92.60 O \\\\nATOM 3555 OD2 ASP A 450 -17.537 6.128 -22.015 1.00 92.60 O \\\\nATOM 3556 N LYS A 451 -18.181 9.440 -20.225 1.00 91.83 N \\\\nATOM 3557 CA LYS A 451 -19.519 10.041 -20.363 1.00 91.83 C \\\\nATOM 3558 C LYS A 451 -19.490 11.549 -20.640 1.00 91.83 C \\\\nATOM 3559 CB LYS A 451 -20.346 9.800 -19.104 1.00 91.83 C \\\\nATOM 3560 O LYS A 451 -20.411 12.062 -21.264 1.00 91.83 O \\\\nATOM 3561 CG LYS A 451 -20.774 8.346 -18.886 1.00 91.83 C \\\\nATOM 3562 CD LYS A 451 -21.546 8.299 -17.564 1.00 91.83 C \\\\nATOM 3563 CE LYS A 451 -21.927 6.876 -17.167 1.00 91.83 C \\\\nATOM 3564 NZ LYS A 451 -22.588 6.894 -15.839 1.00 91.83 N \\\\nATOM 3565 N VAL A 452 -18.482 12.272 -20.151 1.00 91.75 N \\\\nATOM 3566 CA VAL A 452 -18.313 13.704 -20.452 1.00 91.75 C \\\\nATOM 3567 C VAL A 452 -17.764 13.886 -21.868 1.00 91.75 C \\\\nATOM 3568 CB VAL A 452 -17.432 14.393 -19.392 1.00 91.75 C \\\\nATOM 3569 O VAL A 452 -18.312 14.673 -22.635 1.00 91.75 O \\\\nATOM 3570 CG1 VAL A 452 -17.045 15.822 -19.781 1.00 91.75 C \\\\nATOM 3571 CG2 VAL A 452 -18.180 14.477 -18.054 1.00 91.75 C \\\\nATOM 3572 N LEU A 453 -16.729 13.131 -22.246 1.00 91.05 N \\\\nATOM 3573 CA LEU A 453 -16.115 13.199 -23.577 1.00 91.05 C \\\\nATOM 3574 C LEU A 453 -17.106 12.863 -24.695 1.00 91.05 C \\\\nATOM 3575 CB LEU A 453 -14.907 12.248 -23.633 1.00 91.05 C \\\\nATOM 3576 O LEU A 453 -17.135 13.558 -25.707 1.00 91.05 O \\\\nATOM 3577 CG LEU A 453 -13.657 12.782 -22.915 1.00 91.05 C \\\\nATOM 3578 CD1 LEU A 453 -12.607 11.677 -22.819 1.00 91.05 C \\\\nATOM 3579 CD2 LEU A 453 -13.034 13.964 -23.666 1.00 91.05 C \\\\nATOM 3580 N THR A 454 -17.974 11.870 -24.489 1.00 88.74 N \\\\nATOM 3581 CA THR A 454 -19.038 11.510 -25.446 1.00 88.74 C \\\\nATOM 3582 C THR A 454 -20.045 12.639 -25.704 1.00 88.74 C \\\\nATOM 3583 CB THR A 454 -19.797 10.249 -25.000 1.00 88.74 C \\\\nATOM 3584 O THR A 454 -20.705 12.629 -26.739 1.00 88.74 O \\\\nATOM 3585 CG2 THR A 454 -18.964 8.980 -25.160 1.00 88.74 C \\\\nATOM 3586 OG1 THR A 454 -20.152 10.317 -23.644 1.00 88.74 O \\\\nATOM 3587 N GLN A 455 -20.145 13.631 -24.811 1.00 86.80 N \\\\nATOM 3588 CA GLN A 455 -21.014 14.806 -24.960 1.00 86.80 C \\\\nATOM 3589 C GLN A 455 -20.277 16.044 -25.514 1.00 86.80 C \\\\nATOM 3590 CB GLN A 455 -21.657 15.128 -23.598 1.00 86.80 C \\\\nATOM 3591 O GLN A 455 -20.926 16.977 -25.978 1.00 86.80 O \\\\nATOM 3592 CG GLN A 455 -22.542 14.008 -23.028 1.00 86.80 C \\\\nATOM 3593 CD GLN A 455 -23.867 13.803 -23.755 1.00 86.80 C \\\\nATOM 3594 NE2 GLN A 455 -24.498 12.666 -23.561 1.00 86.80 N \\\\nATOM 3595 OE1 GLN A 455 -24.396 14.643 -24.464 1.00 86.80 O \\\\nATOM 3596 N MET A 456 -18.937 16.067 -25.489 1.00 83.78 N \\\\nATOM 3597 CA MET A 456 -18.105 17.230 -25.855 1.00 83.78 C \\\\nATOM 3598 C MET A 456 -17.816 17.361 -27.364 1.00 83.78 C \\\\nATOM 3599 CB MET A 456 -16.786 17.177 -25.059 1.00 83.78 C \\\\nATOM 3600 O MET A 456 -17.165 18.316 -27.781 1.00 83.78 O \\\\nATOM 3601 CG MET A 456 -16.946 17.591 -23.591 1.00 83.78 C \\\\nATOM 3602 SD MET A 456 -17.155 19.371 -23.298 1.00 83.78 S \\\\nATOM 3603 CE MET A 456 -15.520 20.010 -23.739 1.00 83.78 C \\\\nATOM 3604 N GLY A 457 -18.270 16.423 -28.200 1.00 82.72 N \\\\nATOM 3605 CA GLY A 457 -17.965 16.416 -29.636 1.00 82.72 C \\\\nATOM 3606 C GLY A 457 -16.554 15.898 -29.944 1.00 82.72 C \\\\nATOM 3607 O GLY A 457 -16.102 14.932 -29.336 1.00 82.72 O \\\\nATOM 3608 N SER A 458 -15.869 16.502 -30.919 1.00 82.57 N \\\\nATOM 3609 CA SER A 458 -14.536 16.088 -31.390 1.00 82.57 C \\\\nATOM 3610 C SER A 458 -13.502 17.216 -31.256 1.00 82.57 C \\\\nATOM 3611 CB SER A 458 -14.626 15.612 -32.849 1.00 82.57 C \\\\nATOM 3612 O SER A 458 -13.892 18.384 -31.189 1.00 82.57 O \\\\nATOM 3613 OG SER A 458 -14.997 16.664 -33.725 1.00 82.57 O \\\\nATOM 3614 N PRO A 459 -12.187 16.917 -31.300 1.00 83.95 N \\\\nATOM 3615 CA PRO A 459 -11.150 17.944 -31.404 1.00 83.95 C \\\\nATOM 3616 C PRO A 459 -11.398 18.912 -32.571 1.00 83.95 C \\\\nATOM 3617 CB PRO A 459 -9.830 17.189 -31.592 1.00 83.95 C \\\\nATOM 3618 O PRO A 459 -11.916 18.519 -33.619 1.00 83.95 O \\\\nATOM 3619 CG PRO A 459 -10.104 15.818 -30.980 1.00 83.95 C \\\\nATOM 3620 CD PRO A 459 -11.586 15.591 -31.267 1.00 83.95 C \\\\nATOM 3621 N SER A 460 -10.991 20.174 -32.407 1.00 82.81 N \\\\nATOM 3622 CA SER A 460 -11.108 21.203 -33.452 1.00 82.81 C \\\\nATOM 3623 C SER A 460 -10.191 20.929 -34.648 1.00 82.81 C \\\\nATOM 3624 CB SER A 460 -10.787 22.579 -32.856 1.00 82.81 C \\\\nATOM 3625 O SER A 460 -10.555 21.194 -35.795 1.00 82.81 O \\\\nATOM 3626 OG SER A 460 -9.520 22.558 -32.219 1.00 82.81 O \\\\nATOM 3627 N VAL A 461 -9.008 20.365 -34.391 1.00 84.86 N \\\\nATOM 3628 CA VAL A 461 -8.042 19.977 -35.421 1.00 84.86 C \\\\nATOM 3629 C VAL A 461 -8.386 18.581 -35.931 1.00 84.86 C \\\\nATOM 3630 CB VAL A 461 -6.596 20.052 -34.897 1.00 84.86 C \\\\nATOM 3631 O VAL A 461 -8.351 17.603 -35.184 1.00 84.86 O \\\\nATOM 3632 CG1 VAL A 461 -5.591 19.735 -36.012 1.00 84.86 C \\\\nATOM 3633 CG2 VAL A 461 -6.274 21.456 -34.364 1.00 84.86 C \\\\nATOM 3634 N ARG A 462 -8.705 18.476 -37.224 1.00 86.91 N \\\\nATOM 3635 CA ARG A 462 -8.912 17.178 -37.878 1.00 86.91 C \\\\nATOM 3636 C ARG A 462 -7.580 16.446 -38.015 1.00 86.91 C \\\\nATOM 3637 CB ARG A 462 -9.587 17.337 -39.247 1.00 86.91 C \\\\nATOM 3638 O ARG A 462 -6.581 17.039 -38.412 1.00 86.91 O \\\\nATOM 3639 CG ARG A 462 -11.013 17.890 -39.126 1.00 86.91 C \\\\nATOM 3640 CD ARG A 462 -11.684 17.905 -40.502 1.00 86.91 C \\\\nATOM 3641 NE ARG A 462 -13.033 18.495 -40.434 1.00 86.91 N \\\\nATOM 3642 NH1 ARG A 462 -13.544 18.318 -42.665 1.00 86.91 N \\\\nATOM 3643 NH2 ARG A 462 -15.020 19.234 -41.262 1.00 86.91 N \\\\nATOM 3644 CZ ARG A 462 -13.857 18.679 -41.451 1.00 86.91 C \\\\nATOM 3645 N CYS A 463 -7.589 15.148 -37.736 1.00 86.96 N \\\\nATOM 3646 CA CYS A 463 -6.437 14.287 -37.969 1.00 86.96 C \\\\nATOM 3647 C CYS A 463 -6.320 13.944 -39.464 1.00 86.96 C \\\\nATOM 3648 CB CYS A 463 -6.570 13.047 -37.079 1.00 86.96 C \\\\nATOM 3649 O CYS A 463 -7.328 13.671 -40.121 1.00 86.96 O \\\\nATOM 3650 SG CYS A 463 -4.996 12.153 -37.080 1.00 86.96 S \\\\nATOM 3651 N SER A 464 -5.099 13.967 -40.000 1.00 88.07 N \\\\nATOM 3652 CA SER A 464 -4.820 13.510 -41.363 1.00 88.07 C \\\\nATOM 3653 C SER A 464 -4.835 11.983 -41.414 1.00 88.07 C \\\\nATOM 3654 CB SER A 464 -3.461 14.040 -41.824 1.00 88.07 C \\\\nATOM 3655 O SER A 464 -4.310 11.321 -40.526 1.00 88.07 O \\\\nATOM 3656 OG SER A 464 -3.099 13.502 -43.084 1.00 88.07 O \\\\nATOM 3657 N SER A 465 -5.379 11.407 -42.485 1.00 91.00 N \\\\nATOM 3658 CA SER A 465 -5.290 9.965 -42.748 1.00 91.00 C \\\\nATOM 3659 C SER A 465 -3.976 9.551 -43.433 1.00 91.00 C \\\\nATOM 3660 CB SER A 465 -6.508 9.521 -43.561 1.00 91.00 C \\\\nATOM 3661 O SER A 465 -3.864 8.409 -43.870 1.00 91.00 O \\\\nATOM 3662 OG SER A 465 -6.528 10.173 -44.818 1.00 91.00 O \\\\nATOM 3663 N MET A 466 -3.021 10.477 -43.604 1.00 85.74 N \\\\nATOM 3664 CA MET A 466 -1.770 10.264 -44.353 1.00 85.74 C \\\\nATOM 3665 C MET A 466 -0.494 10.702 -43.614 1.00 85.74 C \\\\nATOM 3666 CB MET A 466 -1.822 11.027 -45.692 1.00 85.74 C \\\\nATOM 3667 O MET A 466 0.590 10.472 -44.144 1.00 85.74 O \\\\nATOM 3668 CG MET A 466 -2.996 10.644 -46.597 1.00 85.74 C \\\\nATOM 3669 SD MET A 466 -2.952 11.423 -48.240 1.00 85.74 S \\\\nATOM 3670 CE MET A 466 -1.732 10.371 -49.073 1.00 85.74 C \\\\nATOM 3671 N SER A 467 -0.609 11.397 -42.475 1.00 72.38 N \\\\nATOM 3672 CA SER A 467 0.539 11.969 -41.746 1.00 72.38 C \\\\nATOM 3673 C SER A 467 1.298 10.949 -40.918 1.00 72.38 C \\\\nATOM 3674 CB SER A 467 0.108 13.100 -40.821 1.00 72.38 C \\\\nATOM 3675 O SER A 467 0.599 10.142 -40.264 1.00 72.38 O \\\\nATOM 3676 OG SER A 467 -0.858 12.568 -39.944 1.00 72.38 O \\\\nATOM 3677 OXT SER A 467 2.532 11.126 -40.865 1.00 72.38 O \\\\nTER 3678 SER A 467 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 9, 'score': 0}, {'residue_no': 10, 'score': 0}, {'residue_no': 11, 'score': 0}, {'residue_no': 12, 'score': 0}, {'residue_no': 13, 'score': 0}, {'residue_no': 14, 'score': 0}, {'residue_no': 15, 'score': 0}, {'residue_no': 16, 'score': 0}, {'residue_no': 17, 'score': 0}, {'residue_no': 18, 'score': 0}, {'residue_no': 19, 'score': 0}, {'residue_no': 20, 'score': 0}, {'residue_no': 21, 'score': 0}, {'residue_no': 22, 'score': 0}, {'residue_no': 23, 'score': 0}, {'residue_no': 24, 'score': 0}, {'residue_no': 25, 'score': 0}, {'residue_no': 26, 'score': 0}, {'residue_no': 27, 'score': 0}, {'residue_no': 28, 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{'residue_no': 419, 'score': 0.2302}, {'residue_no': 420, 'score': 0.2175}, {'residue_no': 421, 'score': 0.2119}, {'residue_no': 422, 'score': 0.2108}, {'residue_no': 423, 'score': 0.2133}, {'residue_no': 424, 'score': 0.2155}, {'residue_no': 425, 'score': 0.2078}], 'pdb': 'HEADER 01-JUN-22 \\\\nTITLE ALPHAFOLD MONOMER V2.0 PREDICTION FOR MOTHERS AGAINST DECAPENTAPLEGIC \\\\nTITLE 2 HOMOLOG 3 (P84022) \\\\nCOMPND MOL_ID: 1; \\\\nCOMPND 2 MOLECULE: MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3; \\\\nCOMPND 3 CHAIN: A \\\\nSOURCE MOL_ID: 1; \\\\nSOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; \\\\nSOURCE 3 ORGANISM_TAXID: 9606 \\\\nREMARK 1 \\\\nREMARK 1 REFERENCE 1 \\\\nREMARK 1 AUTH JOHN JUMPER, RICHARD EVANS, ALEXANDER PRITZEL, TIM GREEN, \\\\nREMARK 1 AUTH 2 MICHAEL FIGURNOV, OLAF RONNEBERGER, KATHRYN TUNYASUVUNAKOOL, \\\\nREMARK 1 AUTH 3 RUSS BATES, AUGUSTIN ZIDEK, ANNA POTAPENKO, ALEX BRIDGLAND, \\\\nREMARK 1 AUTH 4 CLEMENS MEYER, SIMON A A KOHL, ANDREW J BALLARD, \\\\nREMARK 1 AUTH 5 ANDREW COWIE, BERNARDINO ROMERA-PAREDES, STANISLAV NIKOLOV, \\\\nREMARK 1 AUTH 6 RISHUB JAIN, JONAS ADLER, TREVOR BACK, STIG PETERSEN, \\\\nREMARK 1 AUTH 7 DAVID REIMAN, ELLEN CLANCY, MICHAL ZIELINSKI, \\\\nREMARK 1 AUTH 8 MARTIN STEINEGGER, MICHALINA PACHOLSKA, TAMAS BERGHAMMER, \\\\nREMARK 1 AUTH 9 DAVID SILVER, ORIOL VINYALS, ANDREW W SENIOR, \\\\nREMARK 1 AUTH10 KORAY KAVUKCUOGLU, PUSHMEET KOHLI, DEMIS HASSABIS \\\\nREMARK 1 TITL HIGHLY ACCURATE PROTEIN STRUCTURE PREDICTION WITH ALPHAFOLD \\\\nREMARK 1 REF NATURE V. 596 583 2021 \\\\nREMARK 1 REFN ISSN 0028-0836 \\\\nREMARK 1 PMID 34265844 \\\\nREMARK 1 DOI 10.1038/s41586-021-03819-2 \\\\nREMARK 1 \\\\nREMARK 1 DISCLAIMERS \\\\nREMARK 1 ALPHAFOLD DATA, COPYRIGHT (2021) DEEPMIND TECHNOLOGIES LIMITED. THE \\\\nREMARK 1 INFORMATION PROVIDED IS THEORETICAL MODELLING ONLY AND CAUTION SHOULD\\\\nREMARK 1 BE EXERCISED IN ITS USE. IT IS PROVIDED \\\"AS-IS\\\" WITHOUT ANY WARRANTY \\\\nREMARK 1 OF ANY KIND, WHETHER EXPRESSED OR IMPLIED. NO WARRANTY IS GIVEN THAT \\\\nREMARK 1 USE OF THE INFORMATION SHALL NOT INFRINGE THE RIGHTS OF ANY THIRD \\\\nREMARK 1 PARTY. THE INFORMATION IS NOT INTENDED TO BE A SUBSTITUTE FOR \\\\nREMARK 1 PROFESSIONAL MEDICAL ADVICE, DIAGNOSIS, OR TREATMENT, AND DOES NOT \\\\nREMARK 1 CONSTITUTE MEDICAL OR OTHER PROFESSIONAL ADVICE. IT IS AVAILABLE FOR \\\\nREMARK 1 ACADEMIC AND COMMERCIAL PURPOSES, UNDER CC-BY 4.0 LICENCE. \\\\nDBREF XXXX A 1 425 UNP P84022 SMAD3_HUMAN 1 425 \\\\nSEQRES 1 A 425 MET SER SER ILE LEU PRO PHE THR PRO PRO ILE VAL LYS \\\\nSEQRES 2 A 425 ARG LEU LEU GLY TRP LYS LYS GLY GLU GLN ASN GLY GLN \\\\nSEQRES 3 A 425 GLU GLU LYS TRP CYS GLU LYS ALA VAL LYS SER LEU VAL \\\\nSEQRES 4 A 425 LYS LYS LEU LYS LYS THR GLY GLN LEU ASP GLU LEU GLU \\\\nSEQRES 5 A 425 LYS ALA ILE THR THR GLN ASN VAL ASN THR LYS CYS ILE \\\\nSEQRES 6 A 425 THR ILE PRO ARG SER LEU ASP GLY ARG LEU GLN VAL SER \\\\nSEQRES 7 A 425 HIS ARG LYS GLY LEU PRO HIS VAL ILE TYR CYS ARG LEU \\\\nSEQRES 8 A 425 TRP ARG TRP PRO ASP LEU HIS SER HIS HIS GLU LEU ARG \\\\nSEQRES 9 A 425 ALA MET GLU LEU CYS GLU PHE ALA PHE ASN MET LYS LYS \\\\nSEQRES 10 A 425 ASP GLU VAL CYS VAL ASN PRO TYR HIS TYR GLN ARG VAL \\\\nSEQRES 11 A 425 GLU THR PRO VAL LEU PRO PRO VAL LEU VAL PRO ARG HIS \\\\nSEQRES 12 A 425 THR GLU ILE PRO ALA GLU PHE PRO PRO LEU ASP ASP TYR \\\\nSEQRES 13 A 425 SER HIS SER ILE PRO GLU ASN THR ASN PHE PRO ALA GLY \\\\nSEQRES 14 A 425 ILE GLU PRO GLN SER ASN ILE PRO GLU THR PRO PRO PRO \\\\nSEQRES 15 A 425 GLY TYR LEU SER GLU ASP GLY GLU THR SER ASP HIS GLN \\\\nSEQRES 16 A 425 MET ASN HIS SER MET ASP ALA GLY SER PRO ASN LEU SER \\\\nSEQRES 17 A 425 PRO ASN PRO MET SER PRO ALA HIS ASN ASN LEU ASP LEU \\\\nSEQRES 18 A 425 GLN PRO VAL THR TYR CYS GLU PRO ALA PHE TRP CYS SER \\\\nSEQRES 19 A 425 ILE SER TYR TYR GLU LEU ASN GLN ARG VAL GLY GLU THR \\\\nSEQRES 20 A 425 PHE HIS ALA SER GLN PRO SER MET THR VAL ASP GLY PHE \\\\nSEQRES 21 A 425 THR ASP PRO SER ASN SER GLU ARG PHE CYS LEU GLY LEU \\\\nSEQRES 22 A 425 LEU SER ASN VAL ASN ARG ASN ALA ALA VAL GLU LEU THR \\\\nSEQRES 23 A 425 ARG ARG HIS ILE GLY ARG GLY VAL ARG LEU TYR TYR ILE \\\\nSEQRES 24 A 425 GLY GLY GLU VAL PHE ALA GLU CYS LEU SER ASP SER ALA \\\\nSEQRES 25 A 425 ILE PHE VAL GLN SER PRO ASN CYS ASN GLN ARG TYR GLY \\\\nSEQRES 26 A 425 TRP HIS PRO ALA THR VAL CYS LYS ILE PRO PRO GLY CYS \\\\nSEQRES 27 A 425 ASN LEU LYS ILE PHE ASN ASN GLN GLU PHE ALA ALA LEU \\\\nSEQRES 28 A 425 LEU ALA GLN SER VAL ASN GLN GLY PHE GLU ALA VAL TYR \\\\nSEQRES 29 A 425 GLN LEU THR ARG MET CYS THR ILE ARG MET SER PHE VAL \\\\nSEQRES 30 A 425 LYS GLY TRP GLY ALA GLU TYR ARG ARG GLN THR VAL THR \\\\nSEQRES 31 A 425 SER THR PRO CYS TRP ILE GLU LEU HIS LEU ASN GLY PRO \\\\nSEQRES 32 A 425 LEU GLN TRP LEU ASP LYS VAL LEU THR GLN MET GLY SER \\\\nSEQRES 33 A 425 PRO SER ILE ARG CYS SER SER VAL SER \\\\nCRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1 \\\\nORIGX1 1.000000 0.000000 0.000000 0.00000 \\\\nORIGX2 0.000000 1.000000 0.000000 0.00000 \\\\nORIGX3 0.000000 0.000000 1.000000 0.00000 \\\\nSCALE1 1.000000 0.000000 0.000000 0.00000 \\\\nSCALE2 0.000000 1.000000 0.000000 0.00000 \\\\nSCALE3 0.000000 0.000000 1.000000 0.00000 \\\\nMODEL 1 \\\\nATOM 1 N MET A 1 4.273 0.848 52.113 1.00 39.24 N \\\\nATOM 2 CA MET A 1 3.232 1.902 52.065 1.00 39.24 C \\\\nATOM 3 C MET A 1 2.383 1.673 50.826 1.00 39.24 C \\\\nATOM 4 CB MET A 1 3.847 3.308 52.057 1.00 39.24 C \\\\nATOM 5 O MET A 1 2.942 1.318 49.796 1.00 39.24 O \\\\nATOM 6 CG MET A 1 4.474 3.642 53.416 1.00 39.24 C \\\\nATOM 7 SD MET A 1 5.360 5.216 53.426 1.00 39.24 S \\\\nATOM 8 CE MET A 1 5.935 5.252 55.146 1.00 39.24 C \\\\nATOM 9 N SER A 2 1.062 1.771 50.948 1.00 36.12 N \\\\nATOM 10 CA SER A 2 0.109 1.246 49.960 1.00 36.12 C \\\\nATOM 11 C SER A 2 0.079 2.048 48.655 1.00 36.12 C \\\\nATOM 12 CB SER A 2 -1.295 1.213 50.580 1.00 36.12 C \\\\nATOM 13 O SER A 2 -0.137 3.258 48.672 1.00 36.12 O \\\\nATOM 14 OG SER A 2 -1.227 0.650 51.880 1.00 36.12 O \\\\nATOM 15 N SER A 3 0.231 1.370 47.514 1.00 38.89 N \\\\nATOM 16 CA SER A 3 0.023 1.960 46.189 1.00 38.89 C \\\\nATOM 17 C SER A 3 -1.462 2.235 45.957 1.00 38.89 C \\\\nATOM 18 CB SER A 3 0.557 1.029 45.093 1.00 38.89 C \\\\nATOM 19 O SER A 3 -2.252 1.303 45.792 1.00 38.89 O \\\\nATOM 20 OG SER A 3 -0.053 -0.245 45.163 1.00 38.89 O \\\\nATOM 21 N ILE A 4 -1.855 3.506 45.916 1.00 47.07 N \\\\nATOM 22 CA ILE A 4 -3.232 3.888 45.596 1.00 47.07 C \\\\nATOM 23 C ILE A 4 -3.496 3.548 44.123 1.00 47.07 C \\\\nATOM 24 CB ILE A 4 -3.468 5.379 45.927 1.00 47.07 C \\\\nATOM 25 O ILE A 4 -2.938 4.179 43.224 1.00 47.07 O \\\\nATOM 26 CG1 ILE A 4 -3.261 5.625 47.443 1.00 47.07 C \\\\nATOM 27 CG2 ILE A 4 -4.879 5.821 45.493 1.00 47.07 C \\\\nATOM 28 CD1 ILE A 4 -3.274 7.105 47.845 1.00 47.07 C \\\\nATOM 29 N LEU A 5 -4.344 2.546 43.868 1.00 53.20 N \\\\nATOM 30 CA LEU A 5 -4.810 2.232 42.516 1.00 53.20 C \\\\nATOM 31 C LEU A 5 -5.549 3.457 41.941 1.00 53.20 C \\\\nATOM 32 CB LEU A 5 -5.721 0.989 42.534 1.00 53.20 C \\\\nATOM 33 O LEU A 5 -6.408 4.021 42.625 1.00 53.20 O \\\\nATOM 34 CG LEU A 5 -4.992 -0.340 42.812 1.00 53.20 C \\\\nATOM 35 CD1 LEU A 5 -6.017 -1.450 43.037 1.00 53.20 C \\\\nATOM 36 CD2 LEU A 5 -4.094 -0.756 41.643 1.00 53.20 C \\\\nATOM 37 N PRO A 6 -5.246 3.897 40.705 1.00 60.37 N \\\\nATOM 38 CA PRO A 6 -5.812 5.125 40.159 1.00 60.37 C \\\\nATOM 39 C PRO A 6 -7.330 4.999 39.986 1.00 60.37 C \\\\nATOM 40 CB PRO A 6 -5.074 5.367 38.837 1.00 60.37 C \\\\nATOM 41 O PRO A 6 -7.816 4.186 39.200 1.00 60.37 O \\\\nATOM 42 CG PRO A 6 -4.604 3.971 38.422 1.00 60.37 C \\\\nATOM 43 CD PRO A 6 -4.319 3.294 39.760 1.00 60.37 C \\\\nATOM 44 N PHE A 7 -8.088 5.832 40.702 1.00 70.62 N \\\\nATOM 45 CA PHE A 7 -9.549 5.804 40.675 1.00 70.62 C \\\\nATOM 46 C PHE A 7 -10.094 6.178 39.288 1.00 70.62 C \\\\nATOM 47 CB PHE A 7 -10.103 6.723 41.773 1.00 70.62 C \\\\nATOM 48 O PHE A 7 -10.023 7.331 38.853 1.00 70.62 O \\\\nATOM 49 CG PHE A 7 -11.618 6.706 41.884 1.00 70.62 C \\\\nATOM 50 CD1 PHE A 7 -12.391 7.683 41.227 1.00 70.62 C \\\\nATOM 51 CD2 PHE A 7 -12.256 5.721 42.662 1.00 70.62 C \\\\nATOM 52 CE1 PHE A 7 -13.792 7.682 41.356 1.00 70.62 C \\\\nATOM 53 CE2 PHE A 7 -13.657 5.718 42.788 1.00 70.62 C \\\\nATOM 54 CZ PHE A 7 -14.425 6.699 42.137 1.00 70.62 C \\\\nATOM 55 N THR A 8 -10.670 5.201 38.590 1.00 75.98 N \\\\nATOM 56 CA THR A 8 -11.340 5.419 37.302 1.00 75.98 C \\\\nATOM 57 C THR A 8 -12.798 5.827 37.530 1.00 75.98 C \\\\nATOM 58 CB THR A 8 -11.204 4.193 36.395 1.00 75.98 C \\\\nATOM 59 O THR A 8 -13.551 5.029 38.095 1.00 75.98 O \\\\nATOM 60 CG2 THR A 8 -11.939 4.349 35.065 1.00 75.98 C \\\\nATOM 61 OG1 THR A 8 -9.832 4.107 36.111 1.00 75.98 O \\\\nATOM 62 N PRO A 9 -13.225 7.032 37.086 1.00 83.88 N \\\\nATOM 63 CA PRO A 9 -14.572 7.540 37.343 1.00 83.88 C \\\\nATOM 64 C PRO A 9 -15.673 6.578 36.863 1.00 83.88 C \\\\nATOM 65 CB PRO A 9 -14.661 8.884 36.610 1.00 83.88 C \\\\nATOM 66 O PRO A 9 -15.524 6.006 35.780 1.00 83.88 O \\\\nATOM 67 CG PRO A 9 -13.212 9.362 36.576 1.00 83.88 C \\\\nATOM 68 CD PRO A 9 -12.428 8.062 36.428 1.00 83.88 C \\\\nATOM 69 N PRO A 10 -16.809 6.445 37.578 1.00 90.89 N \\\\nATOM 70 CA PRO A 10 -17.865 5.488 37.225 1.00 90.89 C \\\\nATOM 71 C PRO A 10 -18.361 5.599 35.776 1.00 90.89 C \\\\nATOM 72 CB PRO A 10 -18.993 5.742 38.231 1.00 90.89 C \\\\nATOM 73 O PRO A 10 -18.535 4.588 35.102 1.00 90.89 O \\\\nATOM 74 CG PRO A 10 -18.247 6.237 39.468 1.00 90.89 C \\\\nATOM 75 CD PRO A 10 -17.097 7.049 38.875 1.00 90.89 C \\\\nATOM 76 N ILE A 11 -18.503 6.820 35.248 1.00 92.27 N \\\\nATOM 77 CA ILE A 11 -18.903 7.038 33.849 1.00 92.27 C \\\\nATOM 78 C ILE A 11 -17.867 6.545 32.827 1.00 92.27 C \\\\nATOM 79 CB ILE A 11 -19.300 8.510 33.624 1.00 92.27 C \\\\nATOM 80 O ILE A 11 -18.248 6.053 31.772 1.00 92.27 O \\\\nATOM 81 CG1 ILE A 11 -19.974 8.665 32.243 1.00 92.27 C \\\\nATOM 82 CG2 ILE A 11 -18.109 9.479 33.789 1.00 92.27 C \\\\nATOM 83 CD1 ILE A 11 -20.932 9.855 32.186 1.00 92.27 C \\\\nATOM 84 N VAL A 12 -16.570 6.592 33.149 1.00 93.66 N \\\\nATOM 85 CA VAL A 12 -15.523 6.020 32.287 1.00 93.66 C \\\\nATOM 86 C VAL A 12 -15.661 4.498 32.246 1.00 93.66 C \\\\nATOM 87 CB VAL A 12 -14.116 6.446 32.749 1.00 93.66 C \\\\nATOM 88 O VAL A 12 -15.583 3.927 31.165 1.00 93.66 O \\\\nATOM 89 CG1 VAL A 12 -12.997 5.748 31.970 1.00 93.66 C \\\\nATOM 90 CG2 VAL A 12 -13.919 7.961 32.599 1.00 93.66 C \\\\nATOM 91 N LYS A 13 -15.937 3.848 33.388 1.00 92.88 N \\\\nATOM 92 CA LYS A 13 -16.201 2.399 33.430 1.00 92.88 C \\\\nATOM 93 C LYS A 13 -17.434 2.024 32.600 1.00 92.88 C \\\\nATOM 94 CB LYS A 13 -16.346 1.887 34.873 1.00 92.88 C \\\\nATOM 95 O LYS A 13 -17.344 1.111 31.788 1.00 92.88 O \\\\nATOM 96 CG LYS A 13 -15.076 2.061 35.721 1.00 92.88 C \\\\nATOM 97 CD LYS A 13 -15.226 1.310 37.053 1.00 92.88 C \\\\nATOM 98 CE LYS A 13 -13.955 1.424 37.902 1.00 92.88 C \\\\nATOM 99 NZ LYS A 13 -14.041 0.572 39.118 1.00 92.88 N \\\\nATOM 100 N ARG A 14 -18.548 2.762 32.738 1.00 93.78 N \\\\nATOM 101 CA ARG A 14 -19.767 2.548 31.930 1.00 93.78 C \\\\nATOM 102 C ARG A 14 -19.486 2.672 30.430 1.00 93.78 C \\\\nATOM 103 CB ARG A 14 -20.903 3.501 32.350 1.00 93.78 C \\\\nATOM 104 O ARG A 14 -19.812 1.762 29.681 1.00 93.78 O \\\\nATOM 105 CG ARG A 14 -21.494 3.160 33.730 1.00 93.78 C \\\\nATOM 106 CD ARG A 14 -22.747 3.992 34.049 1.00 93.78 C \\\\nATOM 107 NE ARG A 14 -22.461 5.438 34.153 1.00 93.78 N \\\\nATOM 108 NH1 ARG A 14 -24.649 6.160 34.141 1.00 93.78 N \\\\nATOM 109 NH2 ARG A 14 -23.035 7.644 34.071 1.00 93.78 N \\\\nATOM 110 CZ ARG A 14 -23.376 6.396 34.150 1.00 93.78 C \\\\nATOM 111 N LEU A 15 -18.822 3.747 29.998 1.00 95.91 N \\\\nATOM 112 CA LEU A 15 -18.482 3.969 28.586 1.00 95.91 C \\\\nATOM 113 C LEU A 15 -17.500 2.923 28.024 1.00 95.91 C \\\\nATOM 114 CB LEU A 15 -17.910 5.388 28.430 1.00 95.91 C \\\\nATOM 115 O LEU A 15 -17.610 2.564 26.853 1.00 95.91 O \\\\nATOM 116 CG LEU A 15 -18.943 6.527 28.539 1.00 95.91 C \\\\nATOM 117 CD1 LEU A 15 -18.201 7.866 28.557 1.00 95.91 C \\\\nATOM 118 CD2 LEU A 15 -19.925 6.546 27.366 1.00 95.91 C \\\\nATOM 119 N LEU A 16 -16.567 2.412 28.835 1.00 94.13 N \\\\nATOM 120 CA LEU A 16 -15.676 1.311 28.444 1.00 94.13 C \\\\nATOM 121 C LEU A 16 -16.401 -0.038 28.358 1.00 94.13 C \\\\nATOM 122 CB LEU A 16 -14.492 1.222 29.420 1.00 94.13 C \\\\nATOM 123 O LEU A 16 -16.011 -0.863 27.540 1.00 94.13 O \\\\nATOM 124 CG LEU A 16 -13.472 2.357 29.249 1.00 94.13 C \\\\nATOM 125 CD1 LEU A 16 -12.531 2.383 30.449 1.00 94.13 C \\\\nATOM 126 CD2 LEU A 16 -12.618 2.203 27.986 1.00 94.13 C \\\\nATOM 127 N GLY A 17 -17.481 -0.245 29.117 1.00 93.26 N \\\\nATOM 128 CA GLY A 17 -18.336 -1.435 29.003 1.00 93.26 C \\\\nATOM 129 C GLY A 17 -19.018 -1.590 27.636 1.00 93.26 C \\\\nATOM 130 O GLY A 17 -19.403 -2.694 27.270 1.00 93.26 O \\\\nATOM 131 N TRP A 18 -19.112 -0.509 26.853 1.00 94.37 N \\\\nATOM 132 CA TRP A 18 -19.606 -0.526 25.470 1.00 94.37 C \\\\nATOM 133 C TRP A 18 -18.494 -0.673 24.414 1.00 94.37 C \\\\nATOM 134 CB TRP A 18 -20.455 0.728 25.232 1.00 94.37 C \\\\nATOM 135 O TRP A 18 -18.788 -0.656 23.216 1.00 94.37 O \\\\nATOM 136 CG TRP A 18 -21.736 0.776 26.007 1.00 94.37 C \\\\nATOM 137 CD1 TRP A 18 -21.931 1.414 27.182 1.00 94.37 C \\\\nATOM 138 CD2 TRP A 18 -23.021 0.170 25.667 1.00 94.37 C \\\\nATOM 139 CE2 TRP A 18 -23.955 0.477 26.701 1.00 94.37 C \\\\nATOM 140 CE3 TRP A 18 -23.489 -0.612 24.590 1.00 94.37 C \\\\nATOM 141 NE1 TRP A 18 -23.237 1.240 27.597 1.00 94.37 N \\\\nATOM 142 CH2 TRP A 18 -25.718 -0.746 25.586 1.00 94.37 C \\\\nATOM 143 CZ2 TRP A 18 -25.283 0.029 26.674 1.00 94.37 C \\\\nATOM 144 CZ3 TRP A 18 -24.821 -1.071 24.553 1.00 94.37 C \\\\nATOM 145 N LYS A 19 -17.220 -0.789 24.822 1.00 93.60 N \\\\nATOM 146 CA LYS A 19 -16.084 -0.967 23.904 1.00 93.60 C \\\\nATOM 147 C LYS A 19 -16.252 -2.261 23.100 1.00 93.60 C \\\\nATOM 148 CB LYS A 19 -14.760 -0.988 24.693 1.00 93.60 C \\\\nATOM 149 O LYS A 19 -16.579 -3.304 23.660 1.00 93.60 O \\\\nATOM 150 CG LYS A 19 -13.503 -0.930 23.802 1.00 93.60 C \\\\nATOM 151 CD LYS A 19 -12.226 -1.437 24.497 1.00 93.60 C \\\\nATOM 152 CE LYS A 19 -12.183 -2.968 24.676 1.00 93.60 C \\\\nATOM 153 NZ LYS A 19 -11.800 -3.697 23.436 1.00 93.60 N \\\\nATOM 154 N LYS A 20 -15.966 -2.216 21.800 1.00 91.32 N \\\\nATOM 155 CA LYS A 20 -15.914 -3.401 20.929 1.00 91.32 C \\\\nATOM 156 C LYS A 20 -14.490 -3.979 20.863 1.00 91.32 C \\\\nATOM 157 CB LYS A 20 -16.505 -3.040 19.552 1.00 91.32 C \\\\nATOM 158 O LYS A 20 -13.519 -3.312 21.226 1.00 91.32 O \\\\nATOM 159 CG LYS A 20 -17.955 -2.527 19.601 1.00 91.32 C \\\\nATOM 160 CD LYS A 20 -18.979 -3.550 20.111 1.00 91.32 C \\\\nATOM 161 CE LYS A 20 -20.374 -2.919 20.037 1.00 91.32 C \\\\nATOM 162 NZ LYS A 20 -21.437 -3.873 20.436 1.00 91.32 N \\\\nATOM 163 N GLY A 21 -14.358 -5.219 20.397 1.00 81.67 N \\\\nATOM 164 CA GLY A 21 -13.065 -5.891 20.200 1.00 81.67 C \\\\nATOM 165 C GLY A 21 -12.430 -6.446 21.479 1.00 81.67 C \\\\nATOM 166 O GLY A 21 -12.852 -6.136 22.595 1.00 81.67 O \\\\nATOM 167 N GLU A 22 -11.402 -7.268 21.296 1.00 73.16 N \\\\nATOM 168 CA GLU A 22 -10.807 -8.129 22.325 1.00 73.16 C \\\\nATOM 169 C GLU A 22 -10.076 -7.372 23.455 1.00 73.16 C \\\\nATOM 170 CB GLU A 22 -9.896 -9.162 21.638 1.00 73.16 C \\\\nATOM 171 O GLU A 22 -9.916 -6.143 23.435 1.00 73.16 O \\\\nATOM 172 CG GLU A 22 -10.687 -10.037 20.647 1.00 73.16 C \\\\nATOM 173 CD GLU A 22 -9.842 -11.154 20.025 1.00 73.16 C \\\\nATOM 174 OE1 GLU A 22 -10.462 -12.159 19.619 1.00 73.16 O \\\\nATOM 175 OE2 GLU A 22 -8.606 -10.975 19.959 1.00 73.16 O \\\\nATOM 176 N GLN A 23 -9.677 -8.115 24.493 1.00 63.69 N \\\\nATOM 177 CA GLN A 23 -9.051 -7.596 25.714 1.00 63.69 C \\\\nATOM 178 C GLN A 23 -7.518 -7.703 25.659 1.00 63.69 C \\\\nATOM 179 CB GLN A 23 -9.645 -8.273 26.962 1.00 63.69 C \\\\nATOM 180 O GLN A 23 -6.890 -8.444 26.413 1.00 63.69 O \\\\nATOM 181 CG GLN A 23 -11.129 -7.933 27.172 1.00 63.69 C \\\\nATOM 182 CD GLN A 23 -11.699 -8.529 28.459 1.00 63.69 C \\\\nATOM 183 NE2 GLN A 23 -13.005 -8.607 28.586 1.00 63.69 N \\\\nATOM 184 OE1 GLN A 23 -11.010 -8.940 29.374 1.00 63.69 O \\\\nATOM 185 N ASN A 24 -6.894 -6.916 24.782 1.00 71.71 N \\\\nATOM 186 CA ASN A 24 -5.439 -6.776 24.752 1.00 71.71 C \\\\nATOM 187 C ASN A 24 -4.978 -5.762 25.814 1.00 71.71 C \\\\nATOM 188 CB ASN A 24 -5.008 -6.406 23.321 1.00 71.71 C \\\\nATOM 189 O ASN A 24 -5.207 -4.560 25.680 1.00 71.71 O \\\\nATOM 190 CG ASN A 24 -5.145 -7.581 22.369 1.00 71.71 C \\\\nATOM 191 ND2 ASN A 24 -5.467 -7.332 21.123 1.00 71.71 N \\\\nATOM 192 OD1 ASN A 24 -4.943 -8.719 22.744 1.00 71.71 O \\\\nATOM 193 N GLY A 25 -4.286 -6.210 26.868 1.00 75.50 N \\\\nATOM 194 CA GLY A 25 -4.008 -5.386 28.061 1.00 75.50 C \\\\nATOM 195 C GLY A 25 -3.187 -4.097 27.844 1.00 75.50 C \\\\nATOM 196 O GLY A 25 -3.244 -3.176 28.665 1.00 75.50 O \\\\nATOM 197 N GLN A 26 -2.430 -3.977 26.746 1.00 77.51 N \\\\nATOM 198 CA GLN A 26 -1.778 -2.713 26.361 1.00 77.51 C \\\\nATOM 199 C GLN A 26 -2.749 -1.751 25.656 1.00 77.51 C \\\\nATOM 200 CB GLN A 26 -0.555 -3.004 25.477 1.00 77.51 C \\\\nATOM 201 O GLN A 26 -2.683 -0.536 25.861 1.00 77.51 O \\\\nATOM 202 CG GLN A 26 0.283 -1.736 25.216 1.00 77.51 C \\\\nATOM 203 CD GLN A 26 1.514 -1.993 24.352 1.00 77.51 C \\\\nATOM 204 NE2 GLN A 26 2.425 -1.051 24.240 1.00 77.51 N \\\\nATOM 205 OE1 GLN A 26 1.687 -3.027 23.745 1.00 77.51 O \\\\nATOM 206 N GLU A 27 -3.650 -2.291 24.839 1.00 83.83 N \\\\nATOM 207 CA GLU A 27 -4.675 -1.543 24.116 1.00 83.83 C \\\\nATOM 208 C GLU A 27 -5.765 -1.040 25.064 1.00 83.83 C \\\\nATOM 209 CB GLU A 27 -5.237 -2.448 23.019 1.00 83.83 C \\\\nATOM 210 O GLU A 27 -6.132 0.131 25.007 1.00 83.83 O \\\\nATOM 211 CG GLU A 27 -6.292 -1.739 22.170 1.00 83.83 C \\\\nATOM 212 CD GLU A 27 -6.606 -2.516 20.890 1.00 83.83 C \\\\nATOM 213 OE1 GLU A 27 -6.997 -1.820 19.927 1.00 83.83 O \\\\nATOM 214 OE2 GLU A 27 -6.412 -3.753 20.889 1.00 83.83 O \\\\nATOM 215 N GLU A 28 -6.189 -1.861 26.023 1.00 86.39 N \\\\nATOM 216 CA GLU A 28 -7.170 -1.496 27.046 1.00 86.39 C \\\\nATOM 217 C GLU A 28 -6.731 -0.262 27.858 1.00 86.39 C \\\\nATOM 218 CB GLU A 28 -7.381 -2.720 27.939 1.00 86.39 C \\\\nATOM 219 O GLU A 28 -7.491 0.700 28.008 1.00 86.39 O \\\\nATOM 220 CG GLU A 28 -8.544 -2.503 28.910 1.00 86.39 C \\\\nATOM 221 CD GLU A 28 -8.803 -3.737 29.776 1.00 86.39 C \\\\nATOM 222 OE1 GLU A 28 -9.988 -3.932 30.119 1.00 86.39 O \\\\nATOM 223 OE2 GLU A 28 -7.809 -4.416 30.120 1.00 86.39 O \\\\nATOM 224 N LYS A 29 -5.456 -0.210 28.275 1.00 89.47 N \\\\nATOM 225 CA LYS A 29 -4.847 0.972 28.919 1.00 89.47 C \\\\nATOM 226 C LYS A 29 -4.855 2.214 28.021 1.00 89.47 C \\\\nATOM 227 CB LYS A 29 -3.401 0.651 29.334 1.00 89.47 C \\\\nATOM 228 O LYS A 29 -4.849 3.338 28.529 1.00 89.47 O \\\\nATOM 229 CG LYS A 29 -3.332 -0.299 30.536 1.00 89.47 C \\\\nATOM 230 CD LYS A 29 -1.881 -0.697 30.847 1.00 89.47 C \\\\nATOM 231 CE LYS A 29 -1.878 -1.706 32.000 1.00 89.47 C \\\\nATOM 232 NZ LYS A 29 -0.524 -2.251 32.277 1.00 89.47 N \\\\nATOM 233 N TRP A 30 -4.836 2.050 26.699 1.00 92.08 N \\\\nATOM 234 CA TRP A 30 -4.953 3.163 25.757 1.00 92.08 C \\\\nATOM 235 C TRP A 30 -6.415 3.594 25.561 1.00 92.08 C \\\\nATOM 236 CB TRP A 30 -4.245 2.826 24.440 1.00 92.08 C \\\\nATOM 237 O TRP A 30 -6.694 4.792 25.632 1.00 92.08 O \\\\nATOM 238 CG TRP A 30 -4.246 3.969 23.477 1.00 92.08 C \\\\nATOM 239 CD1 TRP A 30 -3.329 4.961 23.418 1.00 92.08 C \\\\nATOM 240 CD2 TRP A 30 -5.266 4.301 22.489 1.00 92.08 C \\\\nATOM 241 CE2 TRP A 30 -4.898 5.529 21.862 1.00 92.08 C \\\\nATOM 242 CE3 TRP A 30 -6.468 3.691 22.071 1.00 92.08 C \\\\nATOM 243 NE1 TRP A 30 -3.720 5.898 22.481 1.00 92.08 N \\\\nATOM 244 CH2 TRP A 30 -6.859 5.472 20.450 1.00 92.08 C \\\\nATOM 245 CZ2 TRP A 30 -5.674 6.113 20.851 1.00 92.08 C \\\\nATOM 246 CZ3 TRP A 30 -7.259 4.273 21.064 1.00 92.08 C \\\\nATOM 247 N CYS A 31 -7.352 2.652 25.423 1.00 93.06 N \\\\nATOM 248 CA CYS A 31 -8.793 2.918 25.376 1.00 93.06 C \\\\nATOM 249 C CYS A 31 -9.267 3.664 26.631 1.00 93.06 C \\\\nATOM 250 CB CYS A 31 -9.547 1.589 25.225 1.00 93.06 C \\\\nATOM 251 O CYS A 31 -9.973 4.667 26.526 1.00 93.06 O \\\\nATOM 252 SG CYS A 31 -9.173 0.837 23.618 1.00 93.06 S \\\\nATOM 253 N GLU A 32 -8.811 3.253 27.818 1.00 93.85 N \\\\nATOM 254 CA GLU A 32 -9.129 3.942 29.068 1.00 93.85 C \\\\nATOM 255 C GLU A 32 -8.646 5.403 29.051 1.00 93.85 C \\\\nATOM 256 CB GLU A 32 -8.528 3.173 30.256 1.00 93.85 C \\\\nATOM 257 O GLU A 32 -9.396 6.315 29.410 1.00 93.85 O \\\\nATOM 258 CG GLU A 32 -9.135 3.703 31.560 1.00 93.85 C \\\\nATOM 259 CD GLU A 32 -8.376 3.311 32.819 1.00 93.85 C \\\\nATOM 260 OE1 GLU A 32 -9.063 3.201 33.856 1.00 93.85 O \\\\nATOM 261 OE2 GLU A 32 -7.156 3.567 32.892 1.00 93.85 O \\\\nATOM 262 N LYS A 33 -7.422 5.662 28.568 1.00 94.20 N \\\\nATOM 263 CA LYS A 33 -6.902 7.028 28.384 1.00 94.20 C \\\\nATOM 264 C LYS A 33 -7.714 7.822 27.350 1.00 94.20 C \\\\nATOM 265 CB LYS A 33 -5.416 6.983 27.997 1.00 94.20 C \\\\nATOM 266 O LYS A 33 -7.950 9.012 27.570 1.00 94.20 O \\\\nATOM 267 CG LYS A 33 -4.493 6.589 29.163 1.00 94.20 C \\\\nATOM 268 CD LYS A 33 -3.055 6.448 28.644 1.00 94.20 C \\\\nATOM 269 CE LYS A 33 -2.055 6.087 29.746 1.00 94.20 C \\\\nATOM 270 NZ LYS A 33 -0.678 5.970 29.197 1.00 94.20 N \\\\nATOM 271 N ALA A 34 -8.168 7.195 26.262 1.00 95.40 N \\\\nATOM 272 CA ALA A 34 -8.990 7.833 25.229 1.00 95.40 C \\\\nATOM 273 C ALA A 34 -10.354 8.286 25.776 1.00 95.40 C \\\\nATOM 274 CB ALA A 34 -9.158 6.870 24.043 1.00 95.40 C \\\\nATOM 275 O ALA A 34 -10.758 9.432 25.550 1.00 95.40 O \\\\nATOM 276 N VAL A 35 -11.025 7.426 26.551 1.00 96.53 N \\\\nATOM 277 CA VAL A 35 -12.314 7.731 27.196 1.00 96.53 C \\\\nATOM 278 C VAL A 35 -12.135 8.746 28.331 1.00 96.53 C \\\\nATOM 279 CB VAL A 35 -13.021 6.443 27.671 1.00 96.53 C \\\\nATOM 280 O VAL A 35 -12.880 9.723 28.382 1.00 96.53 O \\\\nATOM 281 CG1 VAL A 35 -14.354 6.736 28.371 1.00 96.53 C \\\\nATOM 282 CG2 VAL A 35 -13.342 5.528 26.481 1.00 96.53 C \\\\nATOM 283 N LYS A 36 -11.109 8.614 29.189 1.00 95.17 N \\\\nATOM 284 CA LYS A 36 -10.775 9.626 30.220 1.00 95.17 C \\\\nATOM 285 C LYS A 36 -10.539 11.013 29.600 1.00 95.17 C \\\\nATOM 286 CB LYS A 36 -9.550 9.177 31.053 1.00 95.17 C \\\\nATOM 287 O LYS A 36 -11.017 12.011 30.141 1.00 95.17 O \\\\nATOM 288 CG LYS A 36 -9.892 8.090 32.090 1.00 95.17 C \\\\nATOM 289 CD LYS A 36 -8.669 7.513 32.836 1.00 95.17 C \\\\nATOM 290 CE LYS A 36 -9.134 6.505 33.906 1.00 95.17 C \\\\nATOM 291 NZ LYS A 36 -8.036 5.721 34.536 1.00 95.17 N \\\\nATOM 292 N SER A 37 -9.846 11.077 28.460 1.00 94.09 N \\\\nATOM 293 CA SER A 37 -9.610 12.319 27.710 1.00 94.09 C \\\\nATOM 294 C SER A 37 -10.909 12.918 27.155 1.00 94.09 C \\\\nATOM 295 CB SER A 37 -8.606 12.064 26.581 1.00 94.09 C \\\\nATOM 296 O SER A 37 -11.152 14.114 27.340 1.00 94.09 O \\\\nATOM 297 OG SER A 37 -8.200 13.280 25.982 1.00 94.09 O \\\\nATOM 298 N LEU A 38 -11.783 12.096 26.554 1.00 96.68 N \\\\nATOM 299 CA LEU A 38 -13.076 12.562 26.040 1.00 96.68 C \\\\nATOM 300 C LEU A 38 -13.976 13.088 27.158 1.00 96.68 C \\\\nATOM 301 CB LEU A 38 -13.802 11.447 25.269 1.00 96.68 C \\\\nATOM 302 O LEU A 38 -14.448 14.217 27.080 1.00 96.68 O \\\\nATOM 303 CG LEU A 38 -15.076 11.947 24.555 1.00 96.68 C \\\\nATOM 304 CD1 LEU A 38 -14.806 13.050 23.532 1.00 96.68 C \\\\nATOM 305 CD2 LEU A 38 -15.755 10.790 23.841 1.00 96.68 C \\\\nATOM 306 N VAL A 39 -14.156 12.316 28.232 1.00 96.49 N \\\\nATOM 307 CA VAL A 39 -14.986 12.708 29.382 1.00 96.49 C \\\\nATOM 308 C VAL A 39 -14.498 14.033 29.979 1.00 96.49 C \\\\nATOM 309 CB VAL A 39 -15.018 11.573 30.428 1.00 96.49 C \\\\nATOM 310 O VAL A 39 -15.314 14.888 30.311 1.00 96.49 O \\\\nATOM 311 CG1 VAL A 39 -15.682 11.974 31.753 1.00 96.49 C \\\\nATOM 312 CG2 VAL A 39 -15.792 10.365 29.885 1.00 96.49 C \\\\nATOM 313 N LYS A 40 -13.179 14.271 30.054 1.00 94.22 N \\\\nATOM 314 CA LYS A 40 -12.625 15.559 30.512 1.00 94.22 C \\\\nATOM 315 C LYS A 40 -12.964 16.731 29.576 1.00 94.22 C \\\\nATOM 316 CB LYS A 40 -11.106 15.419 30.726 1.00 94.22 C \\\\nATOM 317 O LYS A 40 -13.098 17.851 30.064 1.00 94.22 O \\\\nATOM 318 CG LYS A 40 -10.491 16.668 31.386 1.00 94.22 C \\\\nATOM 319 CD LYS A 40 -8.990 16.506 31.663 1.00 94.22 C \\\\nATOM 320 CE LYS A 40 -8.447 17.779 32.331 1.00 94.22 C \\\\nATOM 321 NZ LYS A 40 -6.997 17.680 32.651 1.00 94.22 N \\\\nATOM 322 N LYS A 41 -13.090 16.499 28.263 1.00 94.36 N \\\\nATOM 323 CA LYS A 41 -13.530 17.509 27.283 1.00 94.36 C \\\\nATOM 324 C LYS A 41 -15.037 17.759 27.391 1.00 94.36 C \\\\nATOM 325 CB LYS A 41 -13.121 17.098 25.856 1.00 94.36 C \\\\nATOM 326 O LYS A 41 -15.428 18.897 27.622 1.00 94.36 O \\\\nATOM 327 CG LYS A 41 -11.608 17.217 25.604 1.00 94.36 C \\\\nATOM 328 CD LYS A 41 -11.234 16.547 24.272 1.00 94.36 C \\\\nATOM 329 CE LYS A 41 -9.768 16.770 23.874 1.00 94.36 C \\\\nATOM 330 NZ LYS A 41 -9.555 18.101 23.243 1.00 94.36 N \\\\nATOM 331 N LEU A 42 -15.862 16.712 27.337 1.00 96.39 N \\\\nATOM 332 CA LEU A 42 -17.328 16.840 27.334 1.00 96.39 C \\\\nATOM 333 C LEU A 42 -17.905 17.358 28.660 1.00 96.39 C \\\\nATOM 334 CB LEU A 42 -17.979 15.506 26.942 1.00 96.39 C \\\\nATOM 335 O LEU A 42 -18.942 18.012 28.663 1.00 96.39 O \\\\nATOM 336 CG LEU A 42 -17.544 14.942 25.578 1.00 96.39 C \\\\nATOM 337 CD1 LEU A 42 -18.333 13.665 25.325 1.00 96.39 C \\\\nATOM 338 CD2 LEU A 42 -17.753 15.890 24.400 1.00 96.39 C \\\\nATOM 339 N LYS A 43 -17.206 17.166 29.789 1.00 94.30 N \\\\nATOM 340 CA LYS A 43 -17.544 17.844 31.055 1.00 94.30 C \\\\nATOM 341 C LYS A 43 -17.469 19.373 30.981 1.00 94.30 C \\\\nATOM 342 CB LYS A 43 -16.642 17.354 32.200 1.00 94.30 C \\\\nATOM 343 O LYS A 43 -18.084 20.024 31.814 1.00 94.30 O \\\\nATOM 344 CG LYS A 43 -17.148 16.032 32.779 1.00 94.30 C \\\\nATOM 345 CD LYS A 43 -16.408 15.665 34.067 1.00 94.30 C \\\\nATOM 346 CE LYS A 43 -17.047 14.403 34.653 1.00 94.30 C \\\\nATOM 347 NZ LYS A 43 -16.722 14.247 36.092 1.00 94.30 N \\\\nATOM 348 N LYS A 44 -16.711 19.943 30.036 1.00 92.38 N \\\\nATOM 349 CA LYS A 44 -16.640 21.398 29.828 1.00 92.38 C \\\\nATOM 350 C LYS A 44 -17.732 21.922 28.893 1.00 92.38 C \\\\nATOM 351 CB LYS A 44 -15.269 21.811 29.280 1.00 92.38 C \\\\nATOM 352 O LYS A 44 -18.091 23.083 29.018 1.00 92.38 O \\\\nATOM 353 CG LYS A 44 -14.102 21.511 30.230 1.00 92.38 C \\\\nATOM 354 CD LYS A 44 -12.836 22.153 29.652 1.00 92.38 C \\\\nATOM 355 CE LYS A 44 -11.666 22.080 30.633 1.00 92.38 C \\\\nATOM 356 NZ LYS A 44 -10.614 23.058 30.251 1.00 92.38 N \\\\nATOM 357 N THR A 45 -18.227 21.093 27.971 1.00 92.89 N \\\\nATOM 358 CA THR A 45 -19.252 21.469 26.979 1.00 92.89 C \\\\nATOM 359 C THR A 45 -20.670 21.042 27.372 1.00 92.89 C \\\\nATOM 360 CB THR A 45 -18.919 20.901 25.588 1.00 92.89 C \\\\nATOM 361 O THR A 45 -21.625 21.418 26.705 1.00 92.89 O \\\\nATOM 362 CG2 THR A 45 -17.564 21.381 25.065 1.00 92.89 C \\\\nATOM 363 OG1 THR A 45 -18.867 19.493 25.628 1.00 92.89 O \\\\nATOM 364 N GLY A 46 -20.830 20.240 28.431 1.00 94.57 N \\\\nATOM 365 CA GLY A 46 -22.132 19.732 28.886 1.00 94.57 C \\\\nATOM 366 C GLY A 46 -22.679 18.545 28.078 1.00 94.57 C \\\\nATOM 367 O GLY A 46 -23.735 18.020 28.403 1.00 94.57 O \\\\nATOM 368 N GLN A 47 -21.958 18.059 27.064 1.00 96.14 N \\\\nATOM 369 CA GLN A 47 -22.416 16.991 26.154 1.00 96.14 C \\\\nATOM 370 C GLN A 47 -22.206 15.561 26.691 1.00 96.14 C \\\\nATOM 371 CB GLN A 47 -21.702 17.166 24.809 1.00 96.14 C \\\\nATOM 372 O GLN A 47 -22.330 14.589 25.945 1.00 96.14 O \\\\nATOM 373 CG GLN A 47 -22.141 18.419 24.037 1.00 96.14 C \\\\nATOM 374 CD GLN A 47 -21.126 18.755 22.955 1.00 96.14 C \\\\nATOM 375 NE2 GLN A 47 -21.521 18.931 21.715 1.00 96.14 N \\\\nATOM 376 OE1 GLN A 47 -19.939 18.835 23.226 1.00 96.14 O \\\\nATOM 377 N LEU A 48 -21.836 15.397 27.964 1.00 95.75 N \\\\nATOM 378 CA LEU A 48 -21.485 14.086 28.519 1.00 95.75 C \\\\nATOM 379 C LEU A 48 -22.686 13.127 28.579 1.00 95.75 C \\\\nATOM 380 CB LEU A 48 -20.831 14.306 29.891 1.00 95.75 C \\\\nATOM 381 O LEU A 48 -22.535 11.949 28.255 1.00 95.75 O \\\\nATOM 382 CG LEU A 48 -20.337 13.019 30.577 1.00 95.75 C \\\\nATOM 383 CD1 LEU A 48 -19.330 12.230 29.733 1.00 95.75 C \\\\nATOM 384 CD2 LEU A 48 -19.630 13.420 31.875 1.00 95.75 C \\\\nATOM 385 N ASP A 49 -23.866 13.642 28.922 1.00 95.20 N \\\\nATOM 386 CA ASP A 49 -25.095 12.846 29.016 1.00 95.20 C \\\\nATOM 387 C ASP A 49 -25.645 12.495 27.624 1.00 95.20 C \\\\nATOM 388 CB ASP A 49 -26.134 13.605 29.858 1.00 95.20 C \\\\nATOM 389 O ASP A 49 -26.134 11.388 27.407 1.00 95.20 O \\\\nATOM 390 CG ASP A 49 -25.631 13.965 31.265 1.00 95.20 C \\\\nATOM 391 OD1 ASP A 49 -24.765 13.233 31.800 1.00 95.20 O \\\\nATOM 392 OD2 ASP A 49 -26.072 15.015 31.774 1.00 95.20 O \\\\nATOM 393 N GLU A 50 -25.483 13.388 26.638 1.00 95.50 N \\\\nATOM 394 CA GLU A 50 -25.808 13.097 25.234 1.00 95.50 C \\\\nATOM 395 C GLU A 50 -24.863 12.031 24.649 1.00 95.50 C \\\\nATOM 396 CB GLU A 50 -25.787 14.382 24.385 1.00 95.50 C \\\\nATOM 397 O GLU A 50 -25.313 11.192 23.870 1.00 95.50 O \\\\nATOM 398 CG GLU A 50 -26.900 15.395 24.714 1.00 95.50 C \\\\nATOM 399 CD GLU A 50 -28.309 15.049 24.181 1.00 95.50 C \\\\nATOM 400 OE1 GLU A 50 -29.188 15.943 24.269 1.00 95.50 O \\\\nATOM 401 OE2 GLU A 50 -28.551 13.943 23.643 1.00 95.50 O \\\\nATOM 402 N LEU A 51 -23.579 11.987 25.051 1.00 96.84 N \\\\nATOM 403 CA LEU A 51 -22.690 10.876 24.681 1.00 96.84 C \\\\nATOM 404 C LEU A 51 -23.177 9.565 25.306 1.00 96.84 C \\\\nATOM 405 CB LEU A 51 -21.223 11.158 25.072 1.00 96.84 C \\\\nATOM 406 O LEU A 51 -23.258 8.559 24.608 1.00 96.84 O \\\\nATOM 407 CG LEU A 51 -20.286 9.951 24.816 1.00 96.84 C \\\\nATOM 408 CD1 LEU A 51 -20.083 9.664 23.326 1.00 96.84 C \\\\nATOM 409 CD2 LEU A 51 -18.912 10.170 25.444 1.00 96.84 C \\\\nATOM 410 N GLU A 52 -23.492 9.552 26.604 1.00 95.89 N \\\\nATOM 411 CA GLU A 52 -23.990 8.338 27.260 1.00 95.89 C \\\\nATOM 412 C GLU A 52 -25.289 7.842 26.603 1.00 95.89 C \\\\nATOM 413 CB GLU A 52 -24.130 8.559 28.777 1.00 95.89 C \\\\nATOM 414 O GLU A 52 -25.407 6.653 26.302 1.00 95.89 O \\\\nATOM 415 CG GLU A 52 -24.640 7.275 29.454 1.00 95.89 C \\\\nATOM 416 CD GLU A 52 -24.390 7.180 30.966 1.00 95.89 C \\\\nATOM 417 OE1 GLU A 52 -24.482 6.043 31.488 1.00 95.89 O \\\\nATOM 418 OE2 GLU A 52 -24.034 8.174 31.642 1.00 95.89 O \\\\nATOM 419 N LYS A 53 -26.214 8.750 26.274 1.00 96.28 N \\\\nATOM 420 CA LYS A 53 -27.424 8.464 25.493 1.00 96.28 C \\\\nATOM 421 C LYS A 53 -27.110 7.912 24.098 1.00 96.28 C \\\\nATOM 422 CB LYS A 53 -28.249 9.752 25.426 1.00 96.28 C \\\\nATOM 423 O LYS A 53 -27.704 6.910 23.710 1.00 96.28 O \\\\nATOM 424 CG LYS A 53 -29.588 9.592 24.694 1.00 96.28 C \\\\nATOM 425 CD LYS A 53 -30.278 10.958 24.673 1.00 96.28 C \\\\nATOM 426 CE LYS A 53 -31.551 10.955 23.829 1.00 96.28 C \\\\nATOM 427 NZ LYS A 53 -32.033 12.348 23.670 1.00 96.28 N \\\\nATOM 428 N ALA A 54 -26.183 8.509 23.347 1.00 96.62 N \\\\nATOM 429 CA ALA A 54 -25.789 8.024 22.020 1.00 96.62 C \\\\nATOM 430 C ALA A 54 -25.207 6.605 22.072 1.00 96.62 C \\\\nATOM 431 CB ALA A 54 -24.807 9.023 21.396 1.00 96.62 C \\\\nATOM 432 O ALA A 54 -25.616 5.742 21.298 1.00 96.62 O \\\\nATOM 433 N ILE A 55 -24.307 6.335 23.022 1.00 96.30 N \\\\nATOM 434 CA ILE A 55 -23.681 5.018 23.186 1.00 96.30 C \\\\nATOM 435 C ILE A 55 -24.688 3.949 23.637 1.00 96.30 C \\\\nATOM 436 CB ILE A 55 -22.447 5.125 24.110 1.00 96.30 C \\\\nATOM 437 O ILE A 55 -24.665 2.845 23.099 1.00 96.30 O \\\\nATOM 438 CG1 ILE A 55 -21.331 6.033 23.539 1.00 96.30 C \\\\nATOM 439 CG2 ILE A 55 -21.849 3.744 24.414 1.00 96.30 C \\\\nATOM 440 CD1 ILE A 55 -20.863 5.722 22.113 1.00 96.30 C \\\\nATOM 441 N THR A 56 -25.581 4.270 24.577 1.00 95.54 N \\\\nATOM 442 CA THR A 56 -26.559 3.307 25.119 1.00 95.54 C \\\\nATOM 443 C THR A 56 -27.722 3.023 24.169 1.00 95.54 C \\\\nATOM 444 CB THR A 56 -27.124 3.769 26.470 1.00 95.54 C \\\\nATOM 445 O THR A 56 -28.125 1.871 24.038 1.00 95.54 O \\\\nATOM 446 CG2 THR A 56 -26.083 3.724 27.588 1.00 95.54 C \\\\nATOM 447 OG1 THR A 56 -27.596 5.093 26.403 1.00 95.54 O \\\\nATOM 448 N THR A 57 -28.254 4.044 23.488 1.00 95.70 N \\\\nATOM 449 CA THR A 57 -29.405 3.891 22.573 1.00 95.70 C \\\\nATOM 450 C THR A 57 -29.015 3.477 21.157 1.00 95.70 C \\\\nATOM 451 CB THR A 57 -30.266 5.160 22.486 1.00 95.70 C \\\\nATOM 452 O THR A 57 -29.880 3.040 20.404 1.00 95.70 O \\\\nATOM 453 CG2 THR A 57 -30.814 5.604 23.842 1.00 95.70 C \\\\nATOM 454 OG1 THR A 57 -29.544 6.240 21.937 1.00 95.70 O \\\\nATOM 455 N GLN A 58 -27.740 3.634 20.781 1.00 94.54 N \\\\nATOM 456 CA GLN A 58 -27.207 3.349 19.440 1.00 94.54 C \\\\nATOM 457 C GLN A 58 -27.936 4.101 18.305 1.00 94.54 C \\\\nATOM 458 CB GLN A 58 -27.084 1.828 19.211 1.00 94.54 C \\\\nATOM 459 O GLN A 58 -27.935 3.680 17.149 1.00 94.54 O \\\\nATOM 460 CG GLN A 58 -26.407 1.116 20.396 1.00 94.54 C \\\\nATOM 461 CD GLN A 58 -26.008 -0.329 20.117 1.00 94.54 C \\\\nATOM 462 NE2 GLN A 58 -25.957 -1.152 21.140 1.00 94.54 N \\\\nATOM 463 OE1 GLN A 58 -25.721 -0.762 19.012 1.00 94.54 O \\\\nATOM 464 N ASN A 59 -28.581 5.224 18.639 1.00 92.87 N \\\\nATOM 465 CA ASN A 59 -29.505 5.929 17.759 1.00 92.87 C \\\\nATOM 466 C ASN A 59 -28.807 7.069 16.998 1.00 92.87 C \\\\nATOM 467 CB ASN A 59 -30.705 6.378 18.611 1.00 92.87 C \\\\nATOM 468 O ASN A 59 -28.278 8.009 17.602 1.00 92.87 O \\\\nATOM 469 CG ASN A 59 -31.841 7.012 17.826 1.00 92.87 C \\\\nATOM 470 ND2 ASN A 59 -32.980 7.188 18.452 1.00 92.87 N \\\\nATOM 471 OD1 ASN A 59 -31.741 7.366 16.661 1.00 92.87 O \\\\nATOM 472 N VAL A 60 -28.870 7.013 15.664 1.00 93.35 N \\\\nATOM 473 CA VAL A 60 -28.315 8.020 14.739 1.00 93.35 C \\\\nATOM 474 C VAL A 60 -28.921 9.418 14.934 1.00 93.35 C \\\\nATOM 475 CB VAL A 60 -28.468 7.567 13.270 1.00 93.35 C \\\\nATOM 476 O VAL A 60 -28.242 10.414 14.707 1.00 93.35 O \\\\nATOM 477 CG1 VAL A 60 -27.803 6.203 13.031 1.00 93.35 C \\\\nATOM 478 CG2 VAL A 60 -29.931 7.460 12.812 1.00 93.35 C \\\\nATOM 479 N ASN A 61 -30.156 9.502 15.441 1.00 95.00 N \\\\nATOM 480 CA ASN A 61 -30.888 10.750 15.696 1.00 95.00 C \\\\nATOM 481 C ASN A 61 -30.514 11.426 17.033 1.00 95.00 C \\\\nATOM 482 CB ASN A 61 -32.399 10.475 15.611 1.00 95.00 C \\\\nATOM 483 O ASN A 61 -31.206 12.332 17.498 1.00 95.00 O \\\\nATOM 484 CG ASN A 61 -32.808 9.842 14.297 1.00 95.00 C \\\\nATOM 485 ND2 ASN A 61 -33.213 8.595 14.305 1.00 95.00 N \\\\nATOM 486 OD1 ASN A 61 -32.733 10.444 13.246 1.00 95.00 O \\\\nATOM 487 N THR A 62 -29.454 10.970 17.706 1.00 95.86 N \\\\nATOM 488 CA THR A 62 -28.888 11.690 18.859 1.00 95.86 C \\\\nATOM 489 C THR A 62 -28.145 12.951 18.412 1.00 95.86 C \\\\nATOM 490 CB THR A 62 -28.010 10.785 19.738 1.00 95.86 C \\\\nATOM 491 O THR A 62 -27.816 13.104 17.239 1.00 95.86 O \\\\nATOM 492 CG2 THR A 62 -28.897 9.815 20.518 1.00 95.86 C \\\\nATOM 493 OG1 THR A 62 -27.070 10.038 18.995 1.00 95.86 O \\\\nATOM 494 N LYS A 63 -27.895 13.895 19.330 1.00 96.63 N \\\\nATOM 495 CA LYS A 63 -27.209 15.154 18.992 1.00 96.63 C \\\\nATOM 496 C LYS A 63 -25.744 14.921 18.605 1.00 96.63 C \\\\nATOM 497 CB LYS A 63 -27.314 16.159 20.148 1.00 96.63 C \\\\nATOM 498 O LYS A 63 -25.135 13.909 18.967 1.00 96.63 O \\\\nATOM 499 CG LYS A 63 -28.758 16.609 20.412 1.00 96.63 C \\\\nATOM 500 CD LYS A 63 -28.768 17.696 21.493 1.00 96.63 C \\\\nATOM 501 CE LYS A 63 -30.200 17.996 21.951 1.00 96.63 C \\\\nATOM 502 NZ LYS A 63 -30.233 18.277 23.405 1.00 96.63 N \\\\nATOM 503 N CYS A 64 -25.151 15.889 17.906 1.00 97.45 N \\\\nATOM 504 CA CYS A 64 -23.708 15.899 17.689 1.00 97.45 C \\\\nATOM 505 C CYS A 64 -22.976 16.013 19.035 1.00 97.45 C \\\\nATOM 506 CB CYS A 64 -23.301 17.032 16.736 1.00 97.45 C \\\\nATOM 507 O CYS A 64 -23.277 16.878 19.859 1.00 97.45 O \\\\nATOM 508 SG CYS A 64 -23.929 16.730 15.059 1.00 97.45 S \\\\nATOM 509 N ILE A 65 -21.986 15.145 19.238 1.00 97.88 N \\\\nATOM 510 CA ILE A 65 -21.057 15.214 20.369 1.00 97.88 C \\\\nATOM 511 C ILE A 65 -19.784 15.843 19.833 1.00 97.88 C \\\\nATOM 512 CB ILE A 65 -20.803 13.809 20.959 1.00 97.88 C \\\\nATOM 513 O ILE A 65 -19.086 15.193 19.059 1.00 97.88 O \\\\nATOM 514 CG1 ILE A 65 -22.099 13.076 21.362 1.00 97.88 C \\\\nATOM 515 CG2 ILE A 65 -19.845 13.902 22.156 1.00 97.88 C \\\\nATOM 516 CD1 ILE A 65 -23.002 13.838 22.332 1.00 97.88 C \\\\nATOM 517 N THR A 66 -19.495 17.093 20.178 1.00 97.50 N \\\\nATOM 518 CA THR A 66 -18.403 17.848 19.556 1.00 97.50 C \\\\nATOM 519 C THR A 66 -17.161 17.943 20.436 1.00 97.50 C \\\\nATOM 520 CB THR A 66 -18.853 19.226 19.043 1.00 97.50 C \\\\nATOM 521 O THR A 66 -17.208 17.860 21.663 1.00 97.50 O \\\\nATOM 522 CG2 THR A 66 -19.826 19.092 17.873 1.00 97.50 C \\\\nATOM 523 OG1 THR A 66 -19.484 20.007 20.020 1.00 97.50 O \\\\nATOM 524 N ILE A 67 -16.002 18.076 19.789 1.00 96.58 N \\\\nATOM 525 CA ILE A 67 -14.770 18.550 20.423 1.00 96.58 C \\\\nATOM 526 C ILE A 67 -14.099 19.604 19.526 1.00 96.58 C \\\\nATOM 527 CB ILE A 67 -13.795 17.398 20.776 1.00 96.58 C \\\\nATOM 528 O ILE A 67 -14.213 19.500 18.301 1.00 96.58 O \\\\nATOM 529 CG1 ILE A 67 -13.241 16.667 19.533 1.00 96.58 C \\\\nATOM 530 CG2 ILE A 67 -14.426 16.406 21.772 1.00 96.58 C \\\\nATOM 531 CD1 ILE A 67 -12.138 15.653 19.860 1.00 96.58 C \\\\nATOM 532 N PRO A 68 -13.321 20.546 20.093 1.00 95.38 N \\\\nATOM 533 CA PRO A 68 -12.526 21.483 19.303 1.00 95.38 C \\\\nATOM 534 C PRO A 68 -11.526 20.769 18.386 1.00 95.38 C \\\\nATOM 535 CB PRO A 68 -11.821 22.392 20.315 1.00 95.38 C \\\\nATOM 536 O PRO A 68 -10.821 19.845 18.818 1.00 95.38 O \\\\nATOM 537 CG PRO A 68 -12.757 22.354 21.521 1.00 95.38 C \\\\nATOM 538 CD PRO A 68 -13.292 20.923 21.498 1.00 95.38 C \\\\nATOM 539 N ARG A 69 -11.451 21.219 17.131 1.00 95.13 N \\\\nATOM 540 CA ARG A 69 -10.511 20.757 16.106 1.00 95.13 C \\\\nATOM 541 C ARG A 69 -9.103 21.296 16.394 1.00 95.13 C \\\\nATOM 542 CB ARG A 69 -11.061 21.203 14.735 1.00 95.13 C \\\\nATOM 543 O ARG A 69 -8.932 22.446 16.781 1.00 95.13 O \\\\nATOM 544 CG ARG A 69 -10.229 20.703 13.544 1.00 95.13 C \\\\nATOM 545 CD ARG A 69 -10.828 21.090 12.187 1.00 95.13 C \\\\nATOM 546 NE ARG A 69 -12.138 20.456 11.968 1.00 95.13 N \\\\nATOM 547 NH1 ARG A 69 -11.563 18.720 10.567 1.00 95.13 N \\\\nATOM 548 NH2 ARG A 69 -13.693 19.061 11.108 1.00 95.13 N \\\\nATOM 549 CZ ARG A 69 -12.449 19.415 11.226 1.00 95.13 C \\\\nATOM 550 N SER A 70 -8.076 20.463 16.218 1.00 93.69 N \\\\nATOM 551 CA SER A 70 -6.675 20.911 16.235 1.00 93.69 C \\\\nATOM 552 C SER A 70 -6.253 21.450 14.865 1.00 93.69 C \\\\nATOM 553 CB SER A 70 -5.742 19.766 16.648 1.00 93.69 C \\\\nATOM 554 O SER A 70 -6.850 21.094 13.851 1.00 93.69 O \\\\nATOM 555 OG SER A 70 -5.823 18.716 15.711 1.00 93.69 O \\\\nATOM 556 N LEU A 71 -5.163 22.222 14.818 1.00 90.27 N \\\\nATOM 557 CA LEU A 71 -4.580 22.745 13.570 1.00 90.27 C \\\\nATOM 558 C LEU A 71 -4.316 21.657 12.507 1.00 90.27 C \\\\nATOM 559 CB LEU A 71 -3.256 23.464 13.900 1.00 90.27 C \\\\nATOM 560 O LEU A 71 -4.434 21.918 11.318 1.00 90.27 O \\\\nATOM 561 CG LEU A 71 -3.372 24.686 14.832 1.00 90.27 C \\\\nATOM 562 CD1 LEU A 71 -1.974 25.203 15.173 1.00 90.27 C \\\\nATOM 563 CD2 LEU A 71 -4.171 25.824 14.201 1.00 90.27 C \\\\nATOM 564 N ASP A 72 -3.990 20.431 12.932 1.00 89.02 N \\\\nATOM 565 CA ASP A 72 -3.747 19.272 12.060 1.00 89.02 C \\\\nATOM 566 C ASP A 72 -4.926 18.276 11.996 1.00 89.02 C \\\\nATOM 567 CB ASP A 72 -2.433 18.589 12.485 1.00 89.02 C \\\\nATOM 568 O ASP A 72 -4.781 17.172 11.472 1.00 89.02 O \\\\nATOM 569 CG ASP A 72 -2.514 17.778 13.788 1.00 89.02 C \\\\nATOM 570 OD1 ASP A 72 -3.458 17.970 14.592 1.00 89.02 O \\\\nATOM 571 OD2 ASP A 72 -1.606 16.927 13.988 1.00 89.02 O \\\\nATOM 572 N GLY A 73 -6.075 18.615 12.589 1.00 90.68 N \\\\nATOM 573 CA GLY A 73 -7.268 17.767 12.680 1.00 90.68 C \\\\nATOM 574 C GLY A 73 -7.142 16.496 13.539 1.00 90.68 C \\\\nATOM 575 O GLY A 73 -8.121 15.751 13.646 1.00 90.68 O \\\\nATOM 576 N ARG A 74 -5.982 16.216 14.152 1.00 92.97 N \\\\nATOM 577 CA ARG A 74 -5.710 14.993 14.927 1.00 92.97 C \\\\nATOM 578 C ARG A 74 -5.775 15.211 16.439 1.00 92.97 C \\\\nATOM 579 CB ARG A 74 -4.347 14.404 14.541 1.00 92.97 C \\\\nATOM 580 O ARG A 74 -5.153 16.105 17.007 1.00 92.97 O \\\\nATOM 581 CG ARG A 74 -4.292 13.941 13.076 1.00 92.97 C \\\\nATOM 582 CD ARG A 74 -2.922 13.364 12.704 1.00 92.97 C \\\\nATOM 583 NE ARG A 74 -1.854 14.364 12.867 1.00 92.97 N \\\\nATOM 584 NH1 ARG A 74 -0.127 13.265 11.816 1.00 92.97 N \\\\nATOM 585 NH2 ARG A 74 0.142 15.350 12.593 1.00 92.97 N \\\\nATOM 586 CZ ARG A 74 -0.619 14.312 12.419 1.00 92.97 C \\\\nATOM 587 N LEU A 75 -6.436 14.284 17.124 1.00 94.38 N \\\\nATOM 588 CA LEU A 75 -6.420 14.175 18.577 1.00 94.38 C \\\\nATOM 589 C LEU A 75 -5.216 13.339 19.036 1.00 94.38 C \\\\nATOM 590 CB LEU A 75 -7.766 13.584 19.026 1.00 94.38 C \\\\nATOM 591 O LEU A 75 -4.989 12.231 18.547 1.00 94.38 O \\\\nATOM 592 CG LEU A 75 -7.917 13.386 20.543 1.00 94.38 C \\\\nATOM 593 CD1 LEU A 75 -7.888 14.711 21.312 1.00 94.38 C \\\\nATOM 594 CD2 LEU A 75 -9.250 12.703 20.838 1.00 94.38 C \\\\nATOM 595 N GLN A 76 -4.470 13.843 20.021 1.00 93.91 N \\\\nATOM 596 CA GLN A 76 -3.434 13.075 20.711 1.00 93.91 C \\\\nATOM 597 C GLN A 76 -4.001 12.383 21.959 1.00 93.91 C \\\\nATOM 598 CB GLN A 76 -2.228 13.973 21.025 1.00 93.91 C \\\\nATOM 599 O GLN A 76 -4.605 13.023 22.821 1.00 93.91 O \\\\nATOM 600 CG GLN A 76 -1.059 13.148 21.595 1.00 93.91 C \\\\nATOM 601 CD GLN A 76 0.254 13.919 21.672 1.00 93.91 C \\\\nATOM 602 NE2 GLN A 76 1.165 13.490 22.517 1.00 93.91 N \\\\nATOM 603 OE1 GLN A 76 0.496 14.875 20.951 1.00 93.91 O \\\\nATOM 604 N VAL A 77 -3.755 11.077 22.078 1.00 91.95 N \\\\nATOM 605 CA VAL A 77 -4.080 10.257 23.252 1.00 91.95 C \\\\nATOM 606 C VAL A 77 -2.822 9.505 23.690 1.00 91.95 C \\\\nATOM 607 CB VAL A 77 -5.244 9.286 22.969 1.00 91.95 C \\\\nATOM 608 O VAL A 77 -2.366 8.565 23.031 1.00 91.95 O \\\\nATOM 609 CG1 VAL A 77 -5.582 8.478 24.229 1.00 91.95 C \\\\nATOM 610 CG2 VAL A 77 -6.518 10.015 22.520 1.00 91.95 C \\\\nATOM 611 N SER A 78 -2.256 9.910 24.831 1.00 89.64 N \\\\nATOM 612 CA SER A 78 -0.940 9.453 25.304 1.00 89.64 C \\\\nATOM 613 C SER A 78 0.139 9.719 24.234 1.00 89.64 C \\\\nATOM 614 CB SER A 78 -1.034 7.999 25.813 1.00 89.64 C \\\\nATOM 615 O SER A 78 0.383 10.877 23.894 1.00 89.64 O \\\\nATOM 616 OG SER A 78 -0.107 7.700 26.853 1.00 89.64 O \\\\nATOM 617 N HIS A 79 0.750 8.669 23.679 1.00 87.62 N \\\\nATOM 618 CA HIS A 79 1.822 8.748 22.677 1.00 87.62 C \\\\nATOM 619 C HIS A 79 1.325 8.524 21.236 1.00 87.62 C \\\\nATOM 620 CB HIS A 79 2.944 7.764 23.061 1.00 87.62 C \\\\nATOM 621 O HIS A 79 2.130 8.502 20.315 1.00 87.62 O \\\\nATOM 622 CG HIS A 79 3.317 7.846 24.520 1.00 87.62 C \\\\nATOM 623 CD2 HIS A 79 2.824 7.047 25.515 1.00 87.62 C \\\\nATOM 624 ND1 HIS A 79 4.077 8.821 25.124 1.00 87.62 N \\\\nATOM 625 CE1 HIS A 79 4.026 8.622 26.453 1.00 87.62 C \\\\nATOM 626 NE2 HIS A 79 3.222 7.582 26.741 1.00 87.62 N \\\\nATOM 627 N ARG A 80 0.011 8.342 21.023 1.00 89.06 N \\\\nATOM 628 CA ARG A 80 -0.589 8.120 19.695 1.00 89.06 C \\\\nATOM 629 C ARG A 80 -1.371 9.360 19.252 1.00 89.06 C \\\\nATOM 630 CB ARG A 80 -1.469 6.850 19.695 1.00 89.06 C \\\\nATOM 631 O ARG A 80 -2.094 9.946 20.059 1.00 89.06 O \\\\nATOM 632 CG ARG A 80 -0.694 5.556 20.025 1.00 89.06 C \\\\nATOM 633 CD ARG A 80 -1.591 4.306 19.924 1.00 89.06 C \\\\nATOM 634 NE ARG A 80 -0.844 3.050 20.173 1.00 89.06 N \\\\nATOM 635 NH1 ARG A 80 -2.641 1.599 20.215 1.00 89.06 N \\\\nATOM 636 NH2 ARG A 80 -0.578 0.789 20.395 1.00 89.06 N \\\\nATOM 637 CZ ARG A 80 -1.357 1.827 20.262 1.00 89.06 C \\\\nATOM 638 N LYS A 81 -1.257 9.740 17.976 1.00 91.08 N \\\\nATOM 639 CA LYS A 81 -2.114 10.740 17.313 1.00 91.08 C \\\\nATOM 640 C LYS A 81 -3.033 10.033 16.320 1.00 91.08 C \\\\nATOM 641 CB LYS A 81 -1.278 11.818 16.596 1.00 91.08 C \\\\nATOM 642 O LYS A 81 -2.574 9.153 15.603 1.00 91.08 O \\\\nATOM 643 CG LYS A 81 -0.553 12.772 17.558 1.00 91.08 C \\\\nATOM 644 CD LYS A 81 0.071 13.948 16.788 1.00 91.08 C \\\\nATOM 645 CE LYS A 81 0.707 14.966 17.745 1.00 91.08 C \\\\nATOM 646 NZ LYS A 81 1.119 16.202 17.030 1.00 91.08 N \\\\nATOM 647 N GLY A 82 -4.296 10.436 16.252 1.00 92.21 N \\\\nATOM 648 CA GLY A 82 -5.266 9.886 15.305 1.00 92.21 C \\\\nATOM 649 C GLY A 82 -6.428 10.841 15.063 1.00 92.21 C \\\\nATOM 650 O GLY A 82 -6.586 11.836 15.770 1.00 92.21 O \\\\nATOM 651 N LEU A 83 -7.242 10.562 14.049 1.00 94.68 N \\\\nATOM 652 CA LEU A 83 -8.426 11.370 13.766 1.00 94.68 C \\\\nATOM 653 C LEU A 83 -9.513 11.089 14.819 1.00 94.68 C \\\\nATOM 654 CB LEU A 83 -8.899 11.097 12.332 1.00 94.68 C \\\\nATOM 655 O LEU A 83 -9.783 9.923 15.107 1.00 94.68 O \\\\nATOM 656 CG LEU A 83 -7.914 11.591 11.254 1.00 94.68 C \\\\nATOM 657 CD1 LEU A 83 -8.412 11.182 9.874 1.00 94.68 C \\\\nATOM 658 CD2 LEU A 83 -7.753 13.111 11.288 1.00 94.68 C \\\\nATOM 659 N PRO A 84 -10.135 12.117 15.424 1.00 96.13 N \\\\nATOM 660 CA PRO A 84 -10.963 11.926 16.613 1.00 96.13 C \\\\nATOM 661 C PRO A 84 -12.207 11.073 16.345 1.00 96.13 C \\\\nATOM 662 CB PRO A 84 -11.291 13.335 17.107 1.00 96.13 C \\\\nATOM 663 O PRO A 84 -12.475 10.141 17.096 1.00 96.13 O \\\\nATOM 664 CG PRO A 84 -11.097 14.233 15.887 1.00 96.13 C \\\\nATOM 665 CD PRO A 84 -9.985 13.531 15.117 1.00 96.13 C \\\\nATOM 666 N HIS A 85 -12.917 11.321 15.245 1.00 96.28 N \\\\nATOM 667 CA HIS A 85 -14.066 10.508 14.841 1.00 96.28 C \\\\nATOM 668 C HIS A 85 -13.681 9.035 14.599 1.00 96.28 C \\\\nATOM 669 CB HIS A 85 -14.733 11.152 13.620 1.00 96.28 C \\\\nATOM 670 O HIS A 85 -14.369 8.151 15.099 1.00 96.28 O \\\\nATOM 671 CG HIS A 85 -13.853 11.227 12.398 1.00 96.28 C \\\\nATOM 672 CD2 HIS A 85 -13.950 10.425 11.294 1.00 96.28 C \\\\nATOM 673 ND1 HIS A 85 -12.801 12.094 12.184 1.00 96.28 N \\\\nATOM 674 CE1 HIS A 85 -12.266 11.799 10.989 1.00 96.28 C \\\\nATOM 675 NE2 HIS A 85 -12.924 10.787 10.421 1.00 96.28 N \\\\nATOM 676 N VAL A 86 -12.538 8.761 13.950 1.00 95.91 N \\\\nATOM 677 CA VAL A 86 -12.007 7.394 13.763 1.00 95.91 C \\\\nATOM 678 C VAL A 86 -11.714 6.721 15.103 1.00 95.91 C \\\\nATOM 679 CB VAL A 86 -10.731 7.378 12.895 1.00 95.91 C \\\\nATOM 680 O VAL A 86 -12.126 5.586 15.305 1.00 95.91 O \\\\nATOM 681 CG1 VAL A 86 -10.186 5.964 12.647 1.00 95.91 C \\\\nATOM 682 CG2 VAL A 86 -10.992 7.999 11.526 1.00 95.91 C \\\\nATOM 683 N ILE A 87 -11.056 7.416 16.041 1.00 95.75 N \\\\nATOM 684 CA ILE A 87 -10.737 6.877 17.378 1.00 95.75 C \\\\nATOM 685 C ILE A 87 -12.005 6.382 18.085 1.00 95.75 C \\\\nATOM 686 CB ILE A 87 -9.989 7.938 18.229 1.00 95.75 C \\\\nATOM 687 O ILE A 87 -12.017 5.278 18.627 1.00 95.75 O \\\\nATOM 688 CG1 ILE A 87 -8.549 8.131 17.697 1.00 95.75 C \\\\nATOM 689 CG2 ILE A 87 -9.975 7.568 19.729 1.00 95.75 C \\\\nATOM 690 CD1 ILE A 87 -7.835 9.374 18.251 1.00 95.75 C \\\\nATOM 691 N TYR A 88 -13.070 7.184 18.078 1.00 97.01 N \\\\nATOM 692 CA TYR A 88 -14.292 6.876 18.820 1.00 97.01 C \\\\nATOM 693 C TYR A 88 -15.236 5.921 18.067 1.00 97.01 C \\\\nATOM 694 CB TYR A 88 -14.923 8.197 19.280 1.00 97.01 C \\\\nATOM 695 O TYR A 88 -15.862 5.073 18.706 1.00 97.01 O \\\\nATOM 696 CG TYR A 88 -14.039 8.958 20.269 1.00 97.01 C \\\\nATOM 697 CD1 TYR A 88 -13.650 8.363 21.488 1.00 97.01 C \\\\nATOM 698 CD2 TYR A 88 -13.542 10.235 19.946 1.00 97.01 C \\\\nATOM 699 CE1 TYR A 88 -12.758 9.025 22.356 1.00 97.01 C \\\\nATOM 700 CE2 TYR A 88 -12.657 10.909 20.809 1.00 97.01 C \\\\nATOM 701 OH TYR A 88 -11.359 10.917 22.833 1.00 97.01 O \\\\nATOM 702 CZ TYR A 88 -12.249 10.297 22.010 1.00 97.01 C \\\\nATOM 703 N CYS A 89 -15.259 5.944 16.728 1.00 97.14 N \\\\nATOM 704 CA CYS A 89 -15.911 4.899 15.927 1.00 97.14 C \\\\nATOM 705 C CYS A 89 -15.223 3.538 16.102 1.00 97.14 C \\\\nATOM 706 CB CYS A 89 -15.940 5.300 14.446 1.00 97.14 C \\\\nATOM 707 O CYS A 89 -15.909 2.531 16.282 1.00 97.14 O \\\\nATOM 708 SG CYS A 89 -17.012 6.741 14.207 1.00 97.14 S \\\\nATOM 709 N ARG A 90 -13.881 3.502 16.131 1.00 94.96 N \\\\nATOM 710 CA ARG A 90 -13.118 2.270 16.374 1.00 94.96 C \\\\nATOM 711 C ARG A 90 -13.416 1.683 17.753 1.00 94.96 C \\\\nATOM 712 CB ARG A 90 -11.610 2.504 16.148 1.00 94.96 C \\\\nATOM 713 O ARG A 90 -13.631 0.485 17.889 1.00 94.96 O \\\\nATOM 714 CG ARG A 90 -10.822 1.179 16.147 1.00 94.96 C \\\\nATOM 715 CD ARG A 90 -9.299 1.349 16.072 1.00 94.96 C \\\\nATOM 716 NE ARG A 90 -8.859 1.913 14.783 1.00 94.96 N \\\\nATOM 717 NH1 ARG A 90 -6.593 1.849 15.128 1.00 94.96 N \\\\nATOM 718 NH2 ARG A 90 -7.394 2.582 13.182 1.00 94.96 N \\\\nATOM 719 CZ ARG A 90 -7.620 2.119 14.376 1.00 94.96 C \\\\nATOM 720 N LEU A 91 -13.475 2.541 18.774 1.00 95.35 N \\\\nATOM 721 CA LEU A 91 -13.684 2.125 20.161 1.00 95.35 C \\\\nATOM 722 C LEU A 91 -15.085 1.529 20.399 1.00 95.35 C \\\\nATOM 723 CB LEU A 91 -13.349 3.325 21.071 1.00 95.35 C \\\\nATOM 724 O LEU A 91 -15.193 0.505 21.071 1.00 95.35 O \\\\nATOM 725 CG LEU A 91 -13.069 2.959 22.541 1.00 95.35 C \\\\nATOM 726 CD1 LEU A 91 -12.143 4.000 23.179 1.00 95.35 C \\\\nATOM 727 CD2 LEU A 91 -14.329 2.914 23.405 1.00 95.35 C \\\\nATOM 728 N TRP A 92 -16.144 2.141 19.854 1.00 96.60 N \\\\nATOM 729 CA TRP A 92 -17.537 1.766 20.157 1.00 96.60 C \\\\nATOM 730 C TRP A 92 -18.284 0.994 19.062 1.00 96.60 C \\\\nATOM 731 CB TRP A 92 -18.313 3.021 20.582 1.00 96.60 C \\\\nATOM 732 O TRP A 92 -19.358 0.464 19.347 1.00 96.60 O \\\\nATOM 733 CG TRP A 92 -17.957 3.535 21.942 1.00 96.60 C \\\\nATOM 734 CD1 TRP A 92 -18.066 2.819 23.082 1.00 96.60 C \\\\nATOM 735 CD2 TRP A 92 -17.462 4.850 22.345 1.00 96.60 C \\\\nATOM 736 CE2 TRP A 92 -17.256 4.832 23.759 1.00 96.60 C \\\\nATOM 737 CE3 TRP A 92 -17.178 6.059 21.672 1.00 96.60 C \\\\nATOM 738 NE1 TRP A 92 -17.647 3.572 24.156 1.00 96.60 N \\\\nATOM 739 CH2 TRP A 92 -16.458 7.112 23.753 1.00 96.60 C \\\\nATOM 740 CZ2 TRP A 92 -16.732 5.930 24.453 1.00 96.60 C \\\\nATOM 741 CZ3 TRP A 92 -16.710 7.188 22.373 1.00 96.60 C \\\\nATOM 742 N ARG A 93 -17.759 0.902 17.831 1.00 95.15 N \\\\nATOM 743 CA ARG A 93 -18.455 0.233 16.712 1.00 95.15 C \\\\nATOM 744 C ARG A 93 -17.601 -0.788 15.968 1.00 95.15 C \\\\nATOM 745 CB ARG A 93 -19.070 1.267 15.755 1.00 95.15 C \\\\nATOM 746 O ARG A 93 -17.990 -1.951 15.932 1.00 95.15 O \\\\nATOM 747 CG ARG A 93 -20.137 2.119 16.462 1.00 95.15 C \\\\nATOM 748 CD ARG A 93 -20.863 3.041 15.485 1.00 95.15 C \\\\nATOM 749 NE ARG A 93 -21.743 2.298 14.563 1.00 95.15 N \\\\nATOM 750 NH1 ARG A 93 -22.348 4.110 13.332 1.00 95.15 N \\\\nATOM 751 NH2 ARG A 93 -23.186 2.127 12.794 1.00 95.15 N \\\\nATOM 752 CZ ARG A 93 -22.420 2.840 13.570 1.00 95.15 C \\\\nATOM 753 N TRP A 94 -16.461 -0.377 15.415 1.00 94.17 N \\\\nATOM 754 CA TRP A 94 -15.676 -1.193 14.474 1.00 94.17 C \\\\nATOM 755 C TRP A 94 -14.194 -1.247 14.882 1.00 94.17 C \\\\nATOM 756 CB TRP A 94 -15.855 -0.623 13.061 1.00 94.17 C \\\\nATOM 757 O TRP A 94 -13.423 -0.380 14.469 1.00 94.17 O \\\\nATOM 758 CG TRP A 94 -17.264 -0.527 12.567 1.00 94.17 C \\\\nATOM 759 CD1 TRP A 94 -18.073 -1.569 12.277 1.00 94.17 C \\\\nATOM 760 CD2 TRP A 94 -18.039 0.675 12.283 1.00 94.17 C \\\\nATOM 761 CE2 TRP A 94 -19.324 0.281 11.803 1.00 94.17 C \\\\nATOM 762 CE3 TRP A 94 -17.778 2.060 12.376 1.00 94.17 C \\\\nATOM 763 NE1 TRP A 94 -19.289 -1.098 11.818 1.00 94.17 N \\\\nATOM 764 CH2 TRP A 94 -19.992 2.588 11.501 1.00 94.17 C \\\\nATOM 765 CZ2 TRP A 94 -20.291 1.216 11.407 1.00 94.17 C \\\\nATOM 766 CZ3 TRP A 94 -18.748 3.008 11.999 1.00 94.17 C \\\\nATOM 767 N PRO A 95 -13.767 -2.218 15.713 1.00 91.85 N \\\\nATOM 768 CA PRO A 95 -12.377 -2.334 16.180 1.00 91.85 C \\\\nATOM 769 C PRO A 95 -11.349 -2.409 15.044 1.00 91.85 C \\\\nATOM 770 CB PRO A 95 -12.335 -3.624 17.007 1.00 91.85 C \\\\nATOM 771 O PRO A 95 -10.232 -1.917 15.177 1.00 91.85 O \\\\nATOM 772 CG PRO A 95 -13.776 -3.784 17.471 1.00 91.85 C \\\\nATOM 773 CD PRO A 95 -14.589 -3.261 16.296 1.00 91.85 C \\\\nATOM 774 N ASP A 96 -11.778 -2.981 13.924 1.00 88.11 N \\\\nATOM 775 CA ASP A 96 -11.075 -3.212 12.665 1.00 88.11 C \\\\nATOM 776 C ASP A 96 -11.137 -2.021 11.684 1.00 88.11 C \\\\nATOM 777 CB ASP A 96 -11.697 -4.475 12.048 1.00 88.11 C \\\\nATOM 778 O ASP A 96 -10.795 -2.157 10.514 1.00 88.11 O \\\\nATOM 779 CG ASP A 96 -13.152 -4.244 11.620 1.00 88.11 C \\\\nATOM 780 OD1 ASP A 96 -13.968 -3.756 12.443 1.00 88.11 O \\\\nATOM 781 OD2 ASP A 96 -13.460 -4.509 10.440 1.00 88.11 O \\\\nATOM 782 N LEU A 97 -11.589 -0.845 12.128 1.00 90.03 N \\\\nATOM 783 CA LEU A 97 -11.603 0.378 11.321 1.00 90.03 C \\\\nATOM 784 C LEU A 97 -10.190 0.968 11.204 1.00 90.03 C \\\\nATOM 785 CB LEU A 97 -12.558 1.369 12.005 1.00 90.03 C \\\\nATOM 786 O LEU A 97 -9.690 1.539 12.177 1.00 90.03 O \\\\nATOM 787 CG LEU A 97 -12.699 2.703 11.262 1.00 90.03 C \\\\nATOM 788 CD1 LEU A 97 -13.601 2.541 10.045 1.00 90.03 C \\\\nATOM 789 CD2 LEU A 97 -13.313 3.751 12.188 1.00 90.03 C \\\\nATOM 790 N HIS A 98 -9.561 0.935 10.034 1.00 83.53 N \\\\nATOM 791 CA HIS A 98 -8.185 1.398 9.822 1.00 83.53 C \\\\nATOM 792 C HIS A 98 -8.109 2.885 9.443 1.00 83.53 C \\\\nATOM 793 CB HIS A 98 -7.491 0.500 8.787 1.00 83.53 C \\\\nATOM 794 O HIS A 98 -7.307 3.624 10.024 1.00 83.53 O \\\\nATOM 795 CG HIS A 98 -7.350 -0.918 9.279 1.00 83.53 C \\\\nATOM 796 CD2 HIS A 98 -6.292 -1.441 9.975 1.00 83.53 C \\\\nATOM 797 ND1 HIS A 98 -8.318 -1.894 9.231 1.00 83.53 N \\\\nATOM 798 CE1 HIS A 98 -7.867 -2.964 9.902 1.00 83.53 C \\\\nATOM 799 NE2 HIS A 98 -6.648 -2.722 10.403 1.00 83.53 N \\\\nATOM 800 N SER A 99 -8.966 3.349 8.528 1.00 85.84 N \\\\nATOM 801 CA SER A 99 -8.930 4.700 7.946 1.00 85.84 C \\\\nATOM 802 C SER A 99 -10.231 5.484 8.140 1.00 85.84 C \\\\nATOM 803 CB SER A 99 -8.601 4.601 6.452 1.00 85.84 C \\\\nATOM 804 O SER A 99 -11.318 4.925 8.226 1.00 85.84 O \\\\nATOM 805 OG SER A 99 -8.411 5.893 5.882 1.00 85.84 O \\\\nATOM 806 N HIS A 100 -10.141 6.818 8.123 1.00 89.28 N \\\\nATOM 807 CA HIS A 100 -11.322 7.683 7.992 1.00 89.28 C \\\\nATOM 808 C HIS A 100 -12.066 7.522 6.664 1.00 89.28 C \\\\nATOM 809 CB HIS A 100 -10.934 9.152 8.163 1.00 89.28 C \\\\nATOM 810 O HIS A 100 -13.252 7.814 6.608 1.00 89.28 O \\\\nATOM 811 CG HIS A 100 -10.106 9.767 7.057 1.00 89.28 C \\\\nATOM 812 CD2 HIS A 100 -10.271 11.039 6.582 1.00 89.28 C \\\\nATOM 813 ND1 HIS A 100 -9.054 9.208 6.355 1.00 89.28 N \\\\nATOM 814 CE1 HIS A 100 -8.602 10.136 5.494 1.00 89.28 C \\\\nATOM 815 NE2 HIS A 100 -9.290 11.280 5.620 1.00 89.28 N \\\\nATOM 816 N HIS A 101 -11.389 7.043 5.617 1.00 87.61 N \\\\nATOM 817 CA HIS A 101 -11.995 6.815 4.305 1.00 87.61 C \\\\nATOM 818 C HIS A 101 -13.023 5.667 4.339 1.00 87.61 C \\\\nATOM 819 CB HIS A 101 -10.877 6.550 3.288 1.00 87.61 C \\\\nATOM 820 O HIS A 101 -13.914 5.620 3.502 1.00 87.61 O \\\\nATOM 821 CG HIS A 101 -9.903 7.679 3.043 1.00 87.61 C \\\\nATOM 822 CD2 HIS A 101 -8.576 7.525 2.753 1.00 87.61 C \\\\nATOM 823 ND1 HIS A 101 -10.253 9.008 2.824 1.00 87.61 N \\\\nATOM 824 CE1 HIS A 101 -9.148 9.614 2.366 1.00 87.61 C \\\\nATOM 825 NE2 HIS A 101 -8.114 8.755 2.330 1.00 87.61 N \\\\nATOM 826 N GLU A 102 -12.947 4.778 5.340 1.00 91.34 N \\\\nATOM 827 CA GLU A 102 -13.962 3.748 5.612 1.00 91.34 C \\\\nATOM 828 C GLU A 102 -15.215 4.320 6.298 1.00 91.34 C \\\\nATOM 829 CB GLU A 102 -13.376 2.657 6.521 1.00 91.34 C \\\\nATOM 830 O GLU A 102 -16.148 3.567 6.567 1.00 91.34 O \\\\nATOM 831 CG GLU A 102 -12.282 1.772 5.924 1.00 91.34 C \\\\nATOM 832 CD GLU A 102 -11.709 0.897 7.044 1.00 91.34 C \\\\nATOM 833 OE1 GLU A 102 -10.610 1.257 7.528 1.00 91.34 O \\\\nATOM 834 OE2 GLU A 102 -12.403 -0.044 7.507 1.00 91.34 O \\\\nATOM 835 N LEU A 103 -15.260 5.621 6.617 1.00 94.44 N \\\\nATOM 836 CA LEU A 103 -16.401 6.278 7.252 1.00 94.44 C \\\\nATOM 837 C LEU A 103 -17.027 7.334 6.336 1.00 94.44 C \\\\nATOM 838 CB LEU A 103 -15.993 6.932 8.583 1.00 94.44 C \\\\nATOM 839 O LEU A 103 -16.368 8.273 5.892 1.00 94.44 O \\\\nATOM 840 CG LEU A 103 -15.497 5.984 9.685 1.00 94.44 C \\\\nATOM 841 CD1 LEU A 103 -15.192 6.821 10.931 1.00 94.44 C \\\\nATOM 842 CD2 LEU A 103 -16.527 4.918 10.060 1.00 94.44 C \\\\nATOM 843 N ARG A 104 -18.346 7.257 6.169 1.00 93.98 N \\\\nATOM 844 CA ARG A 104 -19.178 8.341 5.637 1.00 93.98 C \\\\nATOM 845 C ARG A 104 -19.914 9.007 6.796 1.00 93.98 C \\\\nATOM 846 CB ARG A 104 -20.119 7.758 4.574 1.00 93.98 C \\\\nATOM 847 O ARG A 104 -20.406 8.315 7.679 1.00 93.98 O \\\\nATOM 848 CG ARG A 104 -20.871 8.846 3.792 1.00 93.98 C \\\\nATOM 849 CD ARG A 104 -21.746 8.249 2.682 1.00 93.98 C \\\\nATOM 850 NE ARG A 104 -20.942 7.590 1.630 1.00 93.98 N \\\\nATOM 851 NH1 ARG A 104 -22.690 6.672 0.453 1.00 93.98 N \\\\nATOM 852 NH2 ARG A 104 -20.597 6.298 -0.217 1.00 93.98 N \\\\nATOM 853 CZ ARG A 104 -21.412 6.861 0.631 1.00 93.98 C \\\\nATOM 854 N ALA A 105 -19.987 10.334 6.832 1.00 95.58 N \\\\nATOM 855 CA ALA A 105 -20.825 11.016 7.817 1.00 95.58 C \\\\nATOM 856 C ALA A 105 -22.312 10.886 7.449 1.00 95.58 C \\\\nATOM 857 CB ALA A 105 -20.386 12.473 7.934 1.00 95.58 C \\\\nATOM 858 O ALA A 105 -22.654 10.912 6.269 1.00 95.58 O \\\\nATOM 859 N MET A 106 -23.180 10.771 8.454 1.00 94.73 N \\\\nATOM 860 CA MET A 106 -24.633 10.840 8.263 1.00 94.73 C \\\\nATOM 861 C MET A 106 -25.040 12.262 7.857 1.00 94.73 C \\\\nATOM 862 CB MET A 106 -25.367 10.441 9.556 1.00 94.73 C \\\\nATOM 863 O MET A 106 -24.473 13.227 8.368 1.00 94.73 O \\\\nATOM 864 CG MET A 106 -25.076 9.008 10.024 1.00 94.73 C \\\\nATOM 865 SD MET A 106 -25.501 7.677 8.871 1.00 94.73 S \\\\nATOM 866 CE MET A 106 -27.310 7.807 8.826 1.00 94.73 C \\\\nATOM 867 N GLU A 107 -26.060 12.403 7.010 1.00 93.15 N \\\\nATOM 868 CA GLU A 107 -26.558 13.710 6.533 1.00 93.15 C \\\\nATOM 869 C GLU A 107 -27.026 14.628 7.677 1.00 93.15 C \\\\nATOM 870 CB GLU A 107 -27.710 13.476 5.544 1.00 93.15 C \\\\nATOM 871 O GLU A 107 -26.850 15.841 7.622 1.00 93.15 O \\\\nATOM 872 CG GLU A 107 -27.247 12.693 4.303 1.00 93.15 C \\\\nATOM 873 CD GLU A 107 -28.367 12.438 3.284 1.00 93.15 C \\\\nATOM 874 OE1 GLU A 107 -28.010 11.970 2.181 1.00 93.15 O \\\\nATOM 875 OE2 GLU A 107 -29.546 12.670 3.630 1.00 93.15 O \\\\nATOM 876 N LEU A 108 -27.527 14.035 8.765 1.00 93.69 N \\\\nATOM 877 CA LEU A 108 -27.938 14.715 10.001 1.00 93.69 C \\\\nATOM 878 C LEU A 108 -26.760 15.276 10.835 1.00 93.69 C \\\\nATOM 879 CB LEU A 108 -28.760 13.713 10.841 1.00 93.69 C \\\\nATOM 880 O LEU A 108 -26.981 15.903 11.870 1.00 93.69 O \\\\nATOM 881 CG LEU A 108 -30.059 13.205 10.182 1.00 93.69 C \\\\nATOM 882 CD1 LEU A 108 -30.610 12.023 10.982 1.00 93.69 C \\\\nATOM 883 CD2 LEU A 108 -31.133 14.292 10.122 1.00 93.69 C \\\\nATOM 884 N CYS A 109 -25.503 15.021 10.455 1.00 96.21 N \\\\nATOM 885 CA CYS A 109 -24.330 15.402 11.242 1.00 96.21 C \\\\nATOM 886 C CYS A 109 -23.824 16.809 10.888 1.00 96.21 C \\\\nATOM 887 CB CYS A 109 -23.247 14.332 11.086 1.00 96.21 C \\\\nATOM 888 O CYS A 109 -22.939 16.987 10.050 1.00 96.21 O \\\\nATOM 889 SG CYS A 109 -21.880 14.671 12.240 1.00 96.21 S \\\\nATOM 890 N GLU A 110 -24.309 17.816 11.614 1.00 96.46 N \\\\nATOM 891 CA GLU A 110 -23.943 19.229 11.425 1.00 96.46 C \\\\nATOM 892 C GLU A 110 -22.450 19.545 11.646 1.00 96.46 C \\\\nATOM 893 CB GLU A 110 -24.740 20.085 12.415 1.00 96.46 C \\\\nATOM 894 O GLU A 110 -21.980 20.613 11.249 1.00 96.46 O \\\\nATOM 895 CG GLU A 110 -26.263 19.981 12.271 1.00 96.46 C \\\\nATOM 896 CD GLU A 110 -26.979 20.882 13.289 1.00 96.46 C \\\\nATOM 897 OE1 GLU A 110 -28.101 21.328 12.975 1.00 96.46 O \\\\nATOM 898 OE2 GLU A 110 -26.391 21.128 14.371 1.00 96.46 O \\\\nATOM 899 N PHE A 111 -21.695 18.655 12.297 1.00 97.34 N \\\\nATOM 900 CA PHE A 111 -20.281 18.845 12.653 1.00 97.34 C \\\\nATOM 901 C PHE A 111 -19.386 17.721 12.109 1.00 97.34 C \\\\nATOM 902 CB PHE A 111 -20.146 19.067 14.169 1.00 97.34 C \\\\nATOM 903 O PHE A 111 -18.363 17.375 12.709 1.00 97.34 O \\\\nATOM 904 CG PHE A 111 -20.828 20.321 14.674 1.00 97.34 C \\\\nATOM 905 CD1 PHE A 111 -20.106 21.524 14.784 1.00 97.34 C \\\\nATOM 906 CD2 PHE A 111 -22.187 20.286 15.038 1.00 97.34 C \\\\nATOM 907 CE1 PHE A 111 -20.739 22.681 15.274 1.00 97.34 C \\\\nATOM 908 CE2 PHE A 111 -22.828 21.447 15.497 1.00 97.34 C \\\\nATOM 909 CZ PHE A 111 -22.101 22.642 15.627 1.00 97.34 C \\\\nATOM 910 N ALA A 112 -19.768 17.115 10.985 1.00 95.98 N \\\\nATOM 911 CA ALA A 112 -19.009 16.040 10.359 1.00 95.98 C \\\\nATOM 912 C ALA A 112 -17.552 16.444 10.052 1.00 95.98 C \\\\nATOM 913 CB ALA A 112 -19.760 15.597 9.106 1.00 95.98 C \\\\nATOM 914 O ALA A 112 -17.249 17.588 9.699 1.00 95.98 O \\\\nATOM 915 N PHE A 113 -16.612 15.499 10.184 1.00 93.94 N \\\\nATOM 916 CA PHE A 113 -15.178 15.800 10.078 1.00 93.94 C \\\\nATOM 917 C PHE A 113 -14.775 16.480 8.756 1.00 93.94 C \\\\nATOM 918 CB PHE A 113 -14.367 14.516 10.278 1.00 93.94 C \\\\nATOM 919 O PHE A 113 -13.932 17.385 8.777 1.00 93.94 O \\\\nATOM 920 CG PHE A 113 -12.874 14.717 10.076 1.00 93.94 C \\\\nATOM 921 CD1 PHE A 113 -12.257 14.293 8.882 1.00 93.94 C \\\\nATOM 922 CD2 PHE A 113 -12.103 15.355 11.066 1.00 93.94 C \\\\nATOM 923 CE1 PHE A 113 -10.881 14.503 8.686 1.00 93.94 C \\\\nATOM 924 CE2 PHE A 113 -10.724 15.550 10.880 1.00 93.94 C \\\\nATOM 925 CZ PHE A 113 -10.117 15.137 9.681 1.00 93.94 C \\\\nATOM 926 N ASN A 114 -15.397 16.080 7.643 1.00 91.30 N \\\\nATOM 927 CA ASN A 114 -15.186 16.613 6.295 1.00 91.30 C \\\\nATOM 928 C ASN A 114 -15.691 18.056 6.101 1.00 91.30 C \\\\nATOM 929 CB ASN A 114 -15.829 15.658 5.264 1.00 91.30 C \\\\nATOM 930 O ASN A 114 -15.181 18.738 5.219 1.00 91.30 O \\\\nATOM 931 CG ASN A 114 -17.340 15.517 5.407 1.00 91.30 C \\\\nATOM 932 ND2 ASN A 114 -18.054 15.240 4.344 1.00 91.30 N \\\\nATOM 933 OD1 ASN A 114 -17.887 15.635 6.490 1.00 91.30 O \\\\nATOM 934 N MET A 115 -16.607 18.556 6.941 1.00 93.28 N \\\\nATOM 935 CA MET A 115 -17.109 19.941 6.870 1.00 93.28 C \\\\nATOM 936 C MET A 115 -16.089 20.993 7.338 1.00 93.28 C \\\\nATOM 937 CB MET A 115 -18.397 20.097 7.694 1.00 93.28 C \\\\nATOM 938 O MET A 115 -16.359 22.185 7.245 1.00 93.28 O \\\\nATOM 939 CG MET A 115 -19.531 19.178 7.245 1.00 93.28 C \\\\nATOM 940 SD MET A 115 -21.011 19.386 8.269 1.00 93.28 S \\\\nATOM 941 CE MET A 115 -22.025 20.428 7.188 1.00 93.28 C \\\\nATOM 942 N LYS A 116 -14.933 20.574 7.879 1.00 91.49 N \\\\nATOM 943 CA LYS A 116 -13.805 21.437 8.299 1.00 91.49 C \\\\nATOM 944 C LYS A 116 -14.143 22.582 9.284 1.00 91.49 C \\\\nATOM 945 CB LYS A 116 -13.025 21.940 7.064 1.00 91.49 C \\\\nATOM 946 O LYS A 116 -13.315 23.465 9.464 1.00 91.49 O \\\\nATOM 947 CG LYS A 116 -12.402 20.814 6.222 1.00 91.49 C \\\\nATOM 948 CD LYS A 116 -11.661 21.398 5.012 1.00 91.49 C \\\\nATOM 949 CE LYS A 116 -11.126 20.283 4.104 1.00 91.49 C \\\\nATOM 950 NZ LYS A 116 -10.485 20.836 2.882 1.00 91.49 N \\\\nATOM 951 N LYS A 117 -15.291 22.530 9.975 1.00 94.76 N \\\\nATOM 952 CA LYS A 117 -15.671 23.462 11.058 1.00 94.76 C \\\\nATOM 953 C LYS A 117 -14.675 23.438 12.231 1.00 94.76 C \\\\nATOM 954 CB LYS A 117 -17.094 23.133 11.562 1.00 94.76 C \\\\nATOM 955 O LYS A 117 -13.972 22.443 12.419 1.00 94.76 O \\\\nATOM 956 CG LYS A 117 -18.187 23.326 10.495 1.00 94.76 C \\\\nATOM 957 CD LYS A 117 -19.589 23.130 11.097 1.00 94.76 C \\\\nATOM 958 CE LYS A 117 -20.685 23.404 10.057 1.00 94.76 C \\\\nATOM 959 NZ LYS A 117 -22.042 23.260 10.645 1.00 94.76 N \\\\nATOM 960 N ASP A 118 -14.688 24.484 13.060 1.00 95.42 N \\\\nATOM 961 CA ASP A 118 -13.849 24.625 14.270 1.00 95.42 C \\\\nATOM 962 C ASP A 118 -14.050 23.504 15.300 1.00 95.42 C \\\\nATOM 963 CB ASP A 118 -14.163 25.963 14.953 1.00 95.42 C \\\\nATOM 964 O ASP A 118 -13.168 23.209 16.108 1.00 95.42 O \\\\nATOM 965 CG ASP A 118 -13.874 27.158 14.050 1.00 95.42 C \\\\nATOM 966 OD1 ASP A 118 -12.850 27.096 13.335 1.00 95.42 O \\\\nATOM 967 OD2 ASP A 118 -14.713 28.080 14.050 1.00 95.42 O \\\\nATOM 968 N GLU A 119 -15.197 22.831 15.240 1.00 96.27 N \\\\nATOM 969 CA GLU A 119 -15.482 21.617 15.990 1.00 96.27 C \\\\nATOM 970 C GLU A 119 -15.620 20.390 15.078 1.00 96.27 C \\\\nATOM 971 CB GLU A 119 -16.725 21.802 16.862 1.00 96.27 C \\\\nATOM 972 O GLU A 119 -15.860 20.478 13.870 1.00 96.27 O \\\\nATOM 973 CG GLU A 119 -16.575 22.893 17.932 1.00 96.27 C \\\\nATOM 974 CD GLU A 119 -17.483 22.585 19.128 1.00 96.27 C \\\\nATOM 975 OE1 GLU A 119 -16.925 22.384 20.230 1.00 96.27 O \\\\nATOM 976 OE2 GLU A 119 -18.703 22.390 18.922 1.00 96.27 O \\\\nATOM 977 N VAL A 120 -15.467 19.208 15.673 1.00 96.95 N \\\\nATOM 978 CA VAL A 120 -15.663 17.914 15.015 1.00 96.95 C \\\\nATOM 979 C VAL A 120 -16.561 17.015 15.856 1.00 96.95 C \\\\nATOM 980 CB VAL A 120 -14.313 17.253 14.669 1.00 96.95 C \\\\nATOM 981 O VAL A 120 -16.314 16.811 17.046 1.00 96.95 O \\\\nATOM 982 CG1 VAL A 120 -13.321 17.164 15.838 1.00 96.95 C \\\\nATOM 983 CG2 VAL A 120 -14.496 15.836 14.107 1.00 96.95 C \\\\nATOM 984 N CYS A 121 -17.576 16.433 15.216 1.00 97.92 N \\\\nATOM 985 CA CYS A 121 -18.431 15.420 15.813 1.00 97.92 C \\\\nATOM 986 C CYS A 121 -17.659 14.112 16.029 1.00 97.92 C \\\\nATOM 987 CB CYS A 121 -19.679 15.186 14.954 1.00 97.92 C \\\\nATOM 988 O CYS A 121 -17.033 13.574 15.111 1.00 97.92 O \\\\nATOM 989 SG CYS A 121 -20.832 14.159 15.908 1.00 97.92 S \\\\nATOM 990 N VAL A 122 -17.752 13.582 17.243 1.00 97.72 N \\\\nATOM 991 CA VAL A 122 -17.203 12.298 17.686 1.00 97.72 C \\\\nATOM 992 C VAL A 122 -18.285 11.307 18.125 1.00 97.72 C \\\\nATOM 993 CB VAL A 122 -16.141 12.495 18.782 1.00 97.72 C \\\\nATOM 994 O VAL A 122 -17.956 10.257 18.673 1.00 97.72 O \\\\nATOM 995 CG1 VAL A 122 -14.932 13.260 18.234 1.00 97.72 C \\\\nATOM 996 CG2 VAL A 122 -16.642 13.217 20.035 1.00 97.72 C \\\\nATOM 997 N ASN A 123 -19.565 11.613 17.879 1.00 97.71 N \\\\nATOM 998 CA ASN A 123 -20.654 10.650 18.046 1.00 97.71 C \\\\nATOM 999 C ASN A 123 -20.443 9.497 17.044 1.00 97.71 C \\\\nATOM 1000 CB ASN A 123 -22.010 11.357 17.833 1.00 97.71 C \\\\nATOM 1001 O ASN A 123 -20.509 9.739 15.837 1.00 97.71 O \\\\nATOM 1002 CG ASN A 123 -23.206 10.461 18.123 1.00 97.71 C \\\\nATOM 1003 ND2 ASN A 123 -24.356 11.036 18.386 1.00 97.71 N \\\\nATOM 1004 OD1 ASN A 123 -23.101 9.241 18.132 1.00 97.71 O \\\\nATOM 1005 N PRO A 124 -20.192 8.251 17.485 1.00 97.24 N \\\\nATOM 1006 CA PRO A 124 -19.894 7.164 16.560 1.00 97.24 C \\\\nATOM 1007 C PRO A 124 -21.113 6.735 15.729 1.00 97.24 C \\\\nATOM 1008 CB PRO A 124 -19.341 6.042 17.439 1.00 97.24 C \\\\nATOM 1009 O PRO A 124 -20.937 6.063 14.717 1.00 97.24 O \\\\nATOM 1010 CG PRO A 124 -20.066 6.254 18.763 1.00 97.24 C \\\\nATOM 1011 CD PRO A 124 -20.149 7.776 18.862 1.00 97.24 C \\\\nATOM 1012 N TYR A 125 -22.334 7.132 16.107 1.00 97.21 N \\\\nATOM 1013 CA TYR A 125 -23.568 6.894 15.342 1.00 97.21 C \\\\nATOM 1014 C TYR A 125 -23.873 8.001 14.322 1.00 97.21 C \\\\nATOM 1015 CB TYR A 125 -24.731 6.614 16.304 1.00 97.21 C \\\\nATOM 1016 O TYR A 125 -24.833 7.895 13.569 1.00 97.21 O \\\\nATOM 1017 CG TYR A 125 -24.449 5.401 17.166 1.00 97.21 C \\\\nATOM 1018 CD1 TYR A 125 -24.625 4.107 16.637 1.00 97.21 C \\\\nATOM 1019 CD2 TYR A 125 -23.912 5.567 18.455 1.00 97.21 C \\\\nATOM 1020 CE1 TYR A 125 -24.241 2.979 17.387 1.00 97.21 C \\\\nATOM 1021 CE2 TYR A 125 -23.528 4.440 19.204 1.00 97.21 C \\\\nATOM 1022 OH TYR A 125 -23.321 2.060 19.402 1.00 97.21 O \\\\nATOM 1023 CZ TYR A 125 -23.690 3.144 18.673 1.00 97.21 C \\\\nATOM 1024 N HIS A 126 -23.027 9.035 14.238 1.00 97.82 N \\\\nATOM 1025 CA HIS A 126 -23.063 10.054 13.176 1.00 97.82 C \\\\nATOM 1026 C HIS A 126 -22.159 9.726 11.984 1.00 97.82 C \\\\nATOM 1027 CB HIS A 126 -22.751 11.426 13.780 1.00 97.82 C \\\\nATOM 1028 O HIS A 126 -21.988 10.547 11.084 1.00 97.82 O \\\\nATOM 1029 CG HIS A 126 -23.879 12.016 14.583 1.00 97.82 C \\\\nATOM 1030 CD2 HIS A 126 -25.075 11.415 14.857 1.00 97.82 C \\\\nATOM 1031 ND1 HIS A 126 -23.925 13.346 15.007 1.00 97.82 N \\\\nATOM 1032 CE1 HIS A 126 -25.172 13.518 15.476 1.00 97.82 C \\\\nATOM 1033 NE2 HIS A 126 -25.864 12.375 15.425 1.00 97.82 N \\\\nATOM 1034 N TYR A 127 -21.611 8.513 11.960 1.00 97.31 N \\\\nATOM 1035 CA TYR A 127 -20.844 7.963 10.852 1.00 97.31 C \\\\nATOM 1036 C TYR A 127 -21.405 6.582 10.486 1.00 97.31 C \\\\nATOM 1037 CB TYR A 127 -19.353 7.915 11.234 1.00 97.31 C \\\\nATOM 1038 O TYR A 127 -21.826 5.831 11.364 1.00 97.31 O \\\\nATOM 1039 CG TYR A 127 -18.749 9.275 11.566 1.00 97.31 C \\\\nATOM 1040 CD1 TYR A 127 -18.178 10.061 10.546 1.00 97.31 C \\\\nATOM 1041 CD2 TYR A 127 -18.801 9.777 12.883 1.00 97.31 C \\\\nATOM 1042 CE1 TYR A 127 -17.676 11.346 10.836 1.00 97.31 C \\\\nATOM 1043 CE2 TYR A 127 -18.315 11.068 13.176 1.00 97.31 C \\\\nATOM 1044 OH TYR A 127 -17.256 13.099 12.420 1.00 97.31 O \\\\nATOM 1045 CZ TYR A 127 -17.754 11.859 12.148 1.00 97.31 C \\\\nATOM 1046 N GLN A 128 -21.398 6.218 9.210 1.00 94.94 N \\\\nATOM 1047 CA GLN A 128 -21.660 4.866 8.717 1.00 94.94 C \\\\nATOM 1048 C GLN A 128 -20.363 4.307 8.128 1.00 94.94 C \\\\nATOM 1049 CB GLN A 128 -22.818 4.891 7.707 1.00 94.94 C \\\\nATOM 1050 O GLN A 128 -19.571 5.061 7.559 1.00 94.94 O \\\\nATOM 1051 CG GLN A 128 -23.315 3.479 7.337 1.00 94.94 C \\\\nATOM 1052 CD GLN A 128 -24.500 3.481 6.375 1.00 94.94 C \\\\nATOM 1053 NE2 GLN A 128 -24.954 2.326 5.934 1.00 94.94 N \\\\nATOM 1054 OE1 GLN A 128 -25.037 4.517 6.017 1.00 94.94 O \\\\nATOM 1055 N ARG A 129 -20.128 2.999 8.271 1.00 93.24 N \\\\nATOM 1056 CA ARG A 129 -19.017 2.345 7.577 1.00 93.24 C \\\\nATOM 1057 C ARG A 129 -19.354 2.248 6.093 1.00 93.24 C \\\\nATOM 1058 CB ARG A 129 -18.701 0.979 8.201 1.00 93.24 C \\\\nATOM 1059 O ARG A 129 -20.494 1.964 5.745 1.00 93.24 O \\\\nATOM 1060 CG ARG A 129 -17.357 0.430 7.701 1.00 93.24 C \\\\nATOM 1061 CD ARG A 129 -17.001 -0.874 8.416 1.00 93.24 C \\\\nATOM 1062 NE ARG A 129 -15.580 -1.217 8.225 1.00 93.24 N \\\\nATOM 1063 NH1 ARG A 129 -15.545 -3.069 9.565 1.00 93.24 N \\\\nATOM 1064 NH2 ARG A 129 -13.654 -2.316 8.685 1.00 93.24 N \\\\nATOM 1065 CZ ARG A 129 -14.937 -2.199 8.816 1.00 93.24 C \\\\nATOM 1066 N VAL A 130 -18.379 2.493 5.228 1.00 90.59 N \\\\nATOM 1067 CA VAL A 130 -18.525 2.254 3.792 1.00 90.59 C \\\\nATOM 1068 C VAL A 130 -18.584 0.743 3.573 1.00 90.59 C \\\\nATOM 1069 CB VAL A 130 -17.388 2.919 2.995 1.00 90.59 C \\\\nATOM 1070 O VAL A 130 -17.615 0.034 3.834 1.00 90.59 O \\\\nATOM 1071 CG1 VAL A 130 -17.556 2.671 1.492 1.00 90.59 C \\\\nATOM 1072 CG2 VAL A 130 -17.383 4.441 3.214 1.00 90.59 C \\\\nATOM 1073 N GLU A 131 -19.744 0.256 3.146 1.00 83.73 N \\\\nATOM 1074 CA GLU A 131 -19.983 -1.153 2.835 1.00 83.73 C \\\\nATOM 1075 C GLU A 131 -19.492 -1.473 1.415 1.00 83.73 C \\\\nATOM 1076 CB GLU A 131 -21.480 -1.470 3.027 1.00 83.73 C \\\\nATOM 1077 O GLU A 131 -19.639 -0.659 0.501 1.00 83.73 O \\\\nATOM 1078 CG GLU A 131 -21.875 -1.449 4.519 1.00 83.73 C \\\\nATOM 1079 CD GLU A 131 -23.394 -1.409 4.770 1.00 83.73 C \\\\nATOM 1080 OE1 GLU A 131 -23.785 -0.811 5.806 1.00 83.73 O \\\\nATOM 1081 OE2 GLU A 131 -24.150 -1.953 3.938 1.00 83.73 O \\\\nATOM 1082 N THR A 132 -18.902 -2.655 1.219 1.00 81.31 N \\\\nATOM 1083 CA THR A 132 -18.564 -3.156 -0.121 1.00 81.31 C \\\\nATOM 1084 C THR A 132 -19.844 -3.639 -0.803 1.00 81.31 C \\\\nATOM 1085 CB THR A 132 -17.508 -4.271 -0.069 1.00 81.31 C \\\\nATOM 1086 O THR A 132 -20.510 -4.522 -0.257 1.00 81.31 O \\\\nATOM 1087 CG2 THR A 132 -17.101 -4.782 -1.451 1.00 81.31 C \\\\nATOM 1088 OG1 THR A 132 -16.328 -3.776 0.523 1.00 81.31 O \\\\nATOM 1089 N PRO A 133 -20.218 -3.090 -1.974 1.00 82.14 N \\\\nATOM 1090 CA PRO A 133 -21.417 -3.512 -2.676 1.00 82.14 C \\\\nATOM 1091 C PRO A 133 -21.256 -4.949 -3.177 1.00 82.14 C \\\\nATOM 1092 CB PRO A 133 -21.596 -2.513 -3.821 1.00 82.14 C \\\\nATOM 1093 O PRO A 133 -20.198 -5.332 -3.680 1.00 82.14 O \\\\nATOM 1094 CG PRO A 133 -20.167 -2.064 -4.130 1.00 82.14 C \\\\nATOM 1095 CD PRO A 133 -19.492 -2.105 -2.762 1.00 82.14 C \\\\nATOM 1096 N VAL A 134 -22.324 -5.742 -3.076 1.00 84.73 N \\\\nATOM 1097 CA VAL A 134 -22.350 -7.095 -3.640 1.00 84.73 C \\\\nATOM 1098 C VAL A 134 -22.305 -6.989 -5.163 1.00 84.73 C \\\\nATOM 1099 CB VAL A 134 -23.578 -7.896 -3.166 1.00 84.73 C \\\\nATOM 1100 O VAL A 134 -23.174 -6.370 -5.777 1.00 84.73 O \\\\nATOM 1101 CG1 VAL A 134 -23.554 -9.328 -3.718 1.00 84.73 C \\\\nATOM 1102 CG2 VAL A 134 -23.620 -7.990 -1.634 1.00 84.73 C \\\\nATOM 1103 N LEU A 135 -21.278 -7.581 -5.769 1.00 89.09 N \\\\nATOM 1104 CA LEU A 135 -21.108 -7.609 -7.219 1.00 89.09 C \\\\nATOM 1105 C LEU A 135 -21.987 -8.724 -7.819 1.00 89.09 C \\\\nATOM 1106 CB LEU A 135 -19.617 -7.789 -7.561 1.00 89.09 C \\\\nATOM 1107 O LEU A 135 -21.986 -9.837 -7.283 1.00 89.09 O \\\\nATOM 1108 CG LEU A 135 -18.693 -6.691 -6.997 1.00 89.09 C \\\\nATOM 1109 CD1 LEU A 135 -17.229 -7.061 -7.208 1.00 89.09 C \\\\nATOM 1110 CD2 LEU A 135 -18.944 -5.332 -7.652 1.00 89.09 C \\\\nATOM 1111 N PRO A 136 -22.738 -8.465 -8.907 1.00 88.64 N \\\\nATOM 1112 CA PRO A 136 -23.542 -9.495 -9.559 1.00 88.64 C \\\\nATOM 1113 C PRO A 136 -22.634 -10.566 -10.189 1.00 88.64 C \\\\nATOM 1114 CB PRO A 136 -24.372 -8.757 -10.614 1.00 88.64 C \\\\nATOM 1115 O PRO A 136 -21.542 -10.229 -10.650 1.00 88.64 O \\\\nATOM 1116 CG PRO A 136 -23.484 -7.567 -10.984 1.00 88.64 C \\\\nATOM 1117 CD PRO A 136 -22.802 -7.219 -9.660 1.00 88.64 C \\\\nATOM 1118 N PRO A 137 -23.050 -11.845 -10.241 1.00 90.23 N \\\\nATOM 1119 CA PRO A 137 -22.293 -12.873 -10.945 1.00 90.23 C \\\\nATOM 1120 C PRO A 137 -22.248 -12.582 -12.449 1.00 90.23 C \\\\nATOM 1121 CB PRO A 137 -23.010 -14.193 -10.650 1.00 90.23 C \\\\nATOM 1122 O PRO A 137 -23.247 -12.178 -13.044 1.00 90.23 O \\\\nATOM 1123 CG PRO A 137 -24.458 -13.757 -10.418 1.00 90.23 C \\\\nATOM 1124 CD PRO A 137 -24.311 -12.385 -9.756 1.00 90.23 C \\\\nATOM 1125 N VAL A 138 -21.102 -12.848 -13.072 1.00 90.43 N \\\\nATOM 1126 CA VAL A 138 -20.956 -12.812 -14.533 1.00 90.43 C \\\\nATOM 1127 C VAL A 138 -21.520 -14.113 -15.097 1.00 90.43 C \\\\nATOM 1128 CB VAL A 138 -19.483 -12.596 -14.923 1.00 90.43 C \\\\nATOM 1129 O VAL A 138 -21.149 -15.188 -14.634 1.00 90.43 O \\\\nATOM 1130 CG1 VAL A 138 -19.244 -12.761 -16.426 1.00 90.43 C \\\\nATOM 1131 CG2 VAL A 138 -19.033 -11.184 -14.531 1.00 90.43 C \\\\nATOM 1132 N LEU A 139 -22.432 -14.030 -16.064 1.00 90.13 N \\\\nATOM 1133 CA LEU A 139 -23.028 -15.201 -16.710 1.00 90.13 C \\\\nATOM 1134 C LEU A 139 -22.212 -15.571 -17.950 1.00 90.13 C \\\\nATOM 1135 CB LEU A 139 -24.497 -14.911 -17.070 1.00 90.13 C \\\\nATOM 1136 O LEU A 139 -22.111 -14.764 -18.870 1.00 90.13 O \\\\nATOM 1137 CG LEU A 139 -25.419 -14.571 -15.886 1.00 90.13 C \\\\nATOM 1138 CD1 LEU A 139 -26.852 -14.393 -16.388 1.00 90.13 C \\\\nATOM 1139 CD2 LEU A 139 -25.424 -15.658 -14.809 1.00 90.13 C \\\\nATOM 1140 N VAL A 140 -21.646 -16.777 -17.976 1.00 86.83 N \\\\nATOM 1141 CA VAL A 140 -20.816 -17.263 -19.086 1.00 86.83 C \\\\nATOM 1142 C VAL A 140 -21.594 -18.289 -19.916 1.00 86.83 C \\\\nATOM 1143 CB VAL A 140 -19.483 -17.841 -18.578 1.00 86.83 C \\\\nATOM 1144 O VAL A 140 -22.031 -19.297 -19.353 1.00 86.83 O \\\\nATOM 1145 CG1 VAL A 140 -18.603 -18.256 -19.760 1.00 86.83 C \\\\nATOM 1146 CG2 VAL A 140 -18.706 -16.789 -17.774 1.00 86.83 C \\\\nATOM 1147 N PRO A 141 -21.784 -18.080 -21.233 1.00 80.27 N \\\\nATOM 1148 CA PRO A 141 -22.358 -19.094 -22.111 1.00 80.27 C \\\\nATOM 1149 C PRO A 141 -21.443 -20.313 -22.197 1.00 80.27 C \\\\nATOM 1150 CB PRO A 141 -22.534 -18.428 -23.485 1.00 80.27 C \\\\nATOM 1151 O PRO A 141 -20.263 -20.186 -22.524 1.00 80.27 O \\\\nATOM 1152 CG PRO A 141 -22.470 -16.930 -23.190 1.00 80.27 C \\\\nATOM 1153 CD PRO A 141 -21.543 -16.855 -21.981 1.00 80.27 C \\\\nATOM 1154 N ARG A 142 -21.981 -21.514 -21.970 1.00 69.52 N \\\\nATOM 1155 CA ARG A 142 -21.269 -22.736 -22.351 1.00 69.52 C \\\\nATOM 1156 C ARG A 142 -21.185 -22.821 -23.872 1.00 69.52 C \\\\nATOM 1157 CB ARG A 142 -21.953 -23.967 -21.748 1.00 69.52 C \\\\nATOM 1158 O ARG A 142 -22.206 -22.891 -24.551 1.00 69.52 O \\\\nATOM 1159 CG ARG A 142 -21.631 -24.061 -20.254 1.00 69.52 C \\\\nATOM 1160 CD ARG A 142 -22.346 -25.257 -19.638 1.00 69.52 C \\\\nATOM 1161 NE ARG A 142 -21.928 -25.454 -18.243 1.00 69.52 N \\\\nATOM 1162 NH1 ARG A 142 -23.569 -26.951 -17.623 1.00 69.52 N \\\\nATOM 1163 NH2 ARG A 142 -21.996 -26.344 -16.175 1.00 69.52 N \\\\nATOM 1164 CZ ARG A 142 -22.504 -26.251 -17.367 1.00 69.52 C \\\\nATOM 1165 N HIS A 143 -19.965 -22.851 -24.403 1.00 60.13 N \\\\nATOM 1166 CA HIS A 143 -19.725 -23.115 -25.818 1.00 60.13 C \\\\nATOM 1167 C HIS A 143 -20.074 -24.569 -26.163 1.00 60.13 C \\\\nATOM 1168 CB HIS A 143 -18.268 -22.792 -26.187 1.00 60.13 C \\\\nATOM 1169 O HIS A 143 -19.233 -25.460 -26.058 1.00 60.13 O \\\\nATOM 1170 CG HIS A 143 -17.987 -21.319 -26.313 1.00 60.13 C \\\\nATOM 1171 CD2 HIS A 143 -17.154 -20.573 -25.523 1.00 60.13 C \\\\nATOM 1172 ND1 HIS A 143 -18.492 -20.479 -27.280 1.00 60.13 N \\\\nATOM 1173 CE1 HIS A 143 -17.978 -19.255 -27.072 1.00 60.13 C \\\\nATOM 1174 NE2 HIS A 143 -17.155 -19.264 -26.014 1.00 60.13 N \\\\nATOM 1175 N THR A 144 -21.307 -24.802 -26.609 1.00 49.08 N \\\\nATOM 1176 CA THR A 144 -21.659 -25.991 -27.399 1.00 49.08 C \\\\nATOM 1177 C THR A 144 -21.462 -25.753 -28.894 1.00 49.08 C \\\\nATOM 1178 CB THR A 144 -23.084 -26.500 -27.108 1.00 49.08 C \\\\nATOM 1179 O THR A 144 -20.954 -26.644 -29.567 1.00 49.08 O \\\\nATOM 1180 CG2 THR A 144 -23.051 -27.644 -26.096 1.00 49.08 C \\\\nATOM 1181 OG1 THR A 144 -23.908 -25.493 -26.561 1.00 49.08 O \\\\nATOM 1182 N GLU A 145 -21.785 -24.563 -29.417 1.00 43.90 N \\\\nATOM 1183 CA GLU A 145 -21.641 -24.222 -30.844 1.00 43.90 C \\\\nATOM 1184 C GLU A 145 -21.170 -22.762 -31.027 1.00 43.90 C \\\\nATOM 1185 CB GLU A 145 -22.952 -24.520 -31.606 1.00 43.90 C \\\\nATOM 1186 O GLU A 145 -21.480 -21.888 -30.216 1.00 43.90 O \\\\nATOM 1187 CG GLU A 145 -23.310 -26.023 -31.560 1.00 43.90 C \\\\nATOM 1188 CD GLU A 145 -24.548 -26.438 -32.366 1.00 43.90 C \\\\nATOM 1189 OE1 GLU A 145 -24.808 -27.663 -32.400 1.00 43.90 O \\\\nATOM 1190 OE2 GLU A 145 -25.231 -25.551 -32.922 1.00 43.90 O \\\\nATOM 1191 N ILE A 146 -20.371 -22.501 -32.070 1.00 47.79 N \\\\nATOM 1192 CA ILE A 146 -19.771 -21.185 -32.364 1.00 47.79 C \\\\nATOM 1193 C ILE A 146 -20.657 -20.445 -33.383 1.00 47.79 C \\\\nATOM 1194 CB ILE A 146 -18.323 -21.349 -32.905 1.00 47.79 C \\\\nATOM 1195 O ILE A 146 -20.850 -20.977 -34.478 1.00 47.79 O \\\\nATOM 1196 CG1 ILE A 146 -17.401 -22.045 -31.874 1.00 47.79 C \\\\nATOM 1197 CG2 ILE A 146 -17.724 -19.987 -33.308 1.00 47.79 C \\\\nATOM 1198 CD1 ILE A 146 -16.042 -22.481 -32.443 1.00 47.79 C \\\\nATOM 1199 N PRO A 147 -21.147 -19.220 -33.102 1.00 49.95 N \\\\nATOM 1200 CA PRO A 147 -21.773 -18.379 -34.121 1.00 49.95 C \\\\nATOM 1201 C PRO A 147 -20.759 -18.029 -35.219 1.00 49.95 C \\\\nATOM 1202 CB PRO A 147 -22.294 -17.133 -33.392 1.00 49.95 C \\\\nATOM 1203 O PRO A 147 -19.681 -17.514 -34.929 1.00 49.95 O \\\\nATOM 1204 CG PRO A 147 -22.374 -17.575 -31.931 1.00 49.95 C \\\\nATOM 1205 CD PRO A 147 -21.217 -18.565 -31.807 1.00 49.95 C \\\\nATOM 1206 N ALA A 148 -21.093 -18.327 -36.476 1.00 50.53 N \\\\nATOM 1207 CA ALA A 148 -20.153 -18.237 -37.599 1.00 50.53 C \\\\nATOM 1208 C ALA A 148 -19.879 -16.803 -38.099 1.00 50.53 C \\\\nATOM 1209 CB ALA A 148 -20.670 -19.141 -38.724 1.00 50.53 C \\\\nATOM 1210 O ALA A 148 -18.933 -16.601 -38.856 1.00 50.53 O \\\\nATOM 1211 N GLU A 149 -20.677 -15.819 -37.678 1.00 41.11 N \\\\nATOM 1212 CA GLU A 149 -20.536 -14.413 -38.062 1.00 41.11 C \\\\nATOM 1213 C GLU A 149 -20.661 -13.519 -36.822 1.00 41.11 C \\\\nATOM 1214 CB GLU A 149 -21.581 -14.032 -39.128 1.00 41.11 C \\\\nATOM 1215 O GLU A 149 -21.689 -13.507 -36.145 1.00 41.11 O \\\\nATOM 1216 CG GLU A 149 -21.326 -14.731 -40.475 1.00 41.11 C \\\\nATOM 1217 CD GLU A 149 -22.336 -14.338 -41.566 1.00 41.11 C \\\\nATOM 1218 OE1 GLU A 149 -21.917 -14.275 -42.745 1.00 41.11 O \\\\nATOM 1219 OE2 GLU A 149 -23.526 -14.141 -41.230 1.00 41.11 O \\\\nATOM 1220 N PHE A 150 -19.607 -12.752 -36.542 1.00 50.90 N \\\\nATOM 1221 CA PHE A 150 -19.629 -11.622 -35.614 1.00 50.90 C \\\\nATOM 1222 C PHE A 150 -19.395 -10.328 -36.409 1.00 50.90 C \\\\nATOM 1223 CB PHE A 150 -18.581 -11.808 -34.505 1.00 50.90 C \\\\nATOM 1224 O PHE A 150 -18.740 -10.377 -37.456 1.00 50.90 O \\\\nATOM 1225 CG PHE A 150 -18.997 -12.783 -33.417 1.00 50.90 C \\\\nATOM 1226 CD1 PHE A 150 -19.693 -12.318 -32.284 1.00 50.90 C \\\\nATOM 1227 CD2 PHE A 150 -18.701 -14.154 -33.536 1.00 50.90 C \\\\nATOM 1228 CE1 PHE A 150 -20.083 -13.215 -31.273 1.00 50.90 C \\\\nATOM 1229 CE2 PHE A 150 -19.093 -15.053 -32.528 1.00 50.90 C \\\\nATOM 1230 CZ PHE A 150 -19.783 -14.584 -31.395 1.00 50.90 C \\\\nATOM 1231 N PRO A 151 -19.893 -9.167 -35.939 1.00 45.48 N \\\\nATOM 1232 CA PRO A 151 -19.538 -7.879 -36.527 1.00 45.48 C \\\\nATOM 1233 C PRO A 151 -18.012 -7.690 -36.531 1.00 45.48 C \\\\nATOM 1234 CB PRO A 151 -20.222 -6.811 -35.664 1.00 45.48 C \\\\nATOM 1235 O PRO A 151 -17.342 -8.232 -35.645 1.00 45.48 O \\\\nATOM 1236 CG PRO A 151 -21.324 -7.575 -34.931 1.00 45.48 C \\\\nATOM 1237 CD PRO A 151 -20.732 -8.972 -34.769 1.00 45.48 C \\\\nATOM 1238 N PRO A 152 -17.448 -6.916 -37.477 1.00 43.35 N \\\\nATOM 1239 CA PRO A 152 -16.029 -6.596 -37.439 1.00 43.35 C \\\\nATOM 1240 C PRO A 152 -15.691 -5.935 -36.098 1.00 43.35 C \\\\nATOM 1241 CB PRO A 152 -15.767 -5.682 -38.642 1.00 43.35 C \\\\nATOM 1242 O PRO A 152 -16.322 -4.956 -35.703 1.00 43.35 O \\\\nATOM 1243 CG PRO A 152 -17.138 -5.077 -38.950 1.00 43.35 C \\\\nATOM 1244 CD PRO A 152 -18.120 -6.171 -38.530 1.00 43.35 C \\\\nATOM 1245 N LEU A 153 -14.708 -6.500 -35.396 1.00 46.99 N \\\\nATOM 1246 CA LEU A 153 -14.107 -5.858 -34.233 1.00 46.99 C \\\\nATOM 1247 C LEU A 153 -13.436 -4.565 -34.703 1.00 46.99 C \\\\nATOM 1248 CB LEU A 153 -13.072 -6.804 -33.587 1.00 46.99 C \\\\nATOM 1249 O LEU A 153 -12.665 -4.599 -35.664 1.00 46.99 O \\\\nATOM 1250 CG LEU A 153 -13.670 -8.031 -32.874 1.00 46.99 C \\\\nATOM 1251 CD1 LEU A 153 -12.566 -9.043 -32.557 1.00 46.99 C \\\\nATOM 1252 CD2 LEU A 153 -14.346 -7.649 -31.554 1.00 46.99 C \\\\nATOM 1253 N ASP A 154 -13.695 -3.453 -34.013 1.00 44.28 N \\\\nATOM 1254 CA ASP A 154 -12.870 -2.256 -34.164 1.00 44.28 C \\\\nATOM 1255 C ASP A 154 -11.413 -2.634 -33.881 1.00 44.28 C \\\\nATOM 1256 CB ASP A 154 -13.326 -1.135 -33.215 1.00 44.28 C \\\\nATOM 1257 O ASP A 154 -11.113 -3.281 -32.870 1.00 44.28 O \\\\nATOM 1258 CG ASP A 154 -14.562 -0.385 -33.716 1.00 44.28 C \\\\nATOM 1259 OD1 ASP A 154 -14.599 -0.065 -34.926 1.00 44.28 O \\\\nATOM 1260 OD2 ASP A 154 -15.441 -0.101 -32.871 1.00 44.28 O \\\\nATOM 1261 N ASP A 155 -10.504 -2.262 -34.786 1.00 39.25 N \\\\nATOM 1262 CA ASP A 155 -9.109 -2.671 -34.676 1.00 39.25 C \\\\nATOM 1263 C ASP A 155 -8.376 -1.873 -33.589 1.00 39.25 C \\\\nATOM 1264 CB ASP A 155 -8.374 -2.672 -36.023 1.00 39.25 C \\\\nATOM 1265 O ASP A 155 -7.690 -0.873 -33.821 1.00 39.25 O \\\\nATOM 1266 CG ASP A 155 -6.969 -3.266 -35.845 1.00 39.25 C \\\\nATOM 1267 OD1 ASP A 155 -6.731 -3.949 -34.821 1.00 39.25 O \\\\nATOM 1268 OD2 ASP A 155 -6.084 -3.012 -36.687 1.00 39.25 O \\\\nATOM 1269 N TYR A 156 -8.500 -2.367 -32.362 1.00 43.30 N \\\\nATOM 1270 CA TYR A 156 -7.770 -1.886 -31.202 1.00 43.30 C \\\\nATOM 1271 C TYR A 156 -6.262 -2.222 -31.252 1.00 43.30 C \\\\nATOM 1272 CB TYR A 156 -8.485 -2.362 -29.921 1.00 43.30 C \\\\nATOM 1273 O TYR A 156 -5.565 -1.899 -30.285 1.00 43.30 O \\\\nATOM 1274 CG TYR A 156 -9.726 -1.555 -29.566 1.00 43.30 C \\\\nATOM 1275 CD1 TYR A 156 -9.599 -0.300 -28.937 1.00 43.30 C \\\\nATOM 1276 CD2 TYR A 156 -11.012 -2.049 -29.857 1.00 43.30 C \\\\nATOM 1277 CE1 TYR A 156 -10.733 0.470 -28.621 1.00 43.30 C \\\\nATOM 1278 CE2 TYR A 156 -12.154 -1.294 -29.526 1.00 43.30 C \\\\nATOM 1279 OH TYR A 156 -13.120 0.694 -28.593 1.00 43.30 O \\\\nATOM 1280 CZ TYR A 156 -12.018 -0.032 -28.914 1.00 43.30 C \\\\nATOM 1281 N SER A 157 -5.703 -2.776 -32.343 1.00 44.03 N \\\\nATOM 1282 CA SER A 157 -4.243 -2.892 -32.529 1.00 44.03 C \\\\nATOM 1283 C SER A 157 -3.537 -1.535 -32.392 1.00 44.03 C \\\\nATOM 1284 CB SER A 157 -3.889 -3.535 -33.881 1.00 44.03 C \\\\nATOM 1285 O SER A 157 -2.504 -1.435 -31.732 1.00 44.03 O \\\\nATOM 1286 OG SER A 157 -4.039 -2.628 -34.955 1.00 44.03 O \\\\nATOM 1287 N HIS A 158 -4.160 -0.458 -32.880 1.00 38.34 N \\\\nATOM 1288 CA HIS A 158 -3.667 0.916 -32.739 1.00 38.34 C \\\\nATOM 1289 C HIS A 158 -3.891 1.533 -31.347 1.00 38.34 C \\\\nATOM 1290 CB HIS A 158 -4.280 1.774 -33.850 1.00 38.34 C \\\\nATOM 1291 O HIS A 158 -3.365 2.606 -31.059 1.00 38.34 O \\\\nATOM 1292 CG HIS A 158 -3.831 1.351 -35.226 1.00 38.34 C \\\\nATOM 1293 CD2 HIS A 158 -4.630 1.066 -36.301 1.00 38.34 C \\\\nATOM 1294 ND1 HIS A 158 -2.527 1.162 -35.629 1.00 38.34 N \\\\nATOM 1295 CE1 HIS A 158 -2.543 0.778 -36.915 1.00 38.34 C \\\\nATOM 1296 NE2 HIS A 158 -3.798 0.739 -37.379 1.00 38.34 N \\\\nATOM 1297 N SER A 159 -4.625 0.858 -30.456 1.00 38.83 N \\\\nATOM 1298 CA SER A 159 -4.744 1.260 -29.046 1.00 38.83 C \\\\nATOM 1299 C SER A 159 -3.651 0.669 -28.154 1.00 38.83 C \\\\nATOM 1300 CB SER A 159 -6.123 0.917 -28.499 1.00 38.83 C \\\\nATOM 1301 O SER A 159 -3.557 1.043 -26.982 1.00 38.83 O \\\\nATOM 1302 OG SER A 159 -6.218 -0.454 -28.156 1.00 38.83 O \\\\nATOM 1303 N ILE A 160 -2.822 -0.242 -28.689 1.00 40.21 N \\\\nATOM 1304 CA ILE A 160 -1.624 -0.744 -28.015 1.00 40.21 C \\\\nATOM 1305 C ILE A 160 -0.648 0.430 -27.888 1.00 40.21 C \\\\nATOM 1306 CB ILE A 160 -0.969 -1.918 -28.780 1.00 40.21 C \\\\nATOM 1307 O ILE A 160 -0.074 0.861 -28.888 1.00 40.21 O \\\\nATOM 1308 CG1 ILE A 160 -1.959 -3.092 -28.956 1.00 40.21 C \\\\nATOM 1309 CG2 ILE A 160 0.289 -2.393 -28.019 1.00 40.21 C \\\\nATOM 1310 CD1 ILE A 160 -1.440 -4.208 -29.872 1.00 40.21 C \\\\nATOM 1311 N PRO A 161 -0.412 0.962 -26.681 1.00 43.58 N \\\\nATOM 1312 CA PRO A 161 0.552 2.023 -26.524 1.00 43.58 C \\\\nATOM 1313 C PRO A 161 1.932 1.384 -26.370 1.00 43.58 C \\\\nATOM 1314 CB PRO A 161 0.068 2.791 -25.297 1.00 43.58 C \\\\nATOM 1315 O PRO A 161 2.152 0.600 -25.449 1.00 43.58 O \\\\nATOM 1316 CG PRO A 161 -0.750 1.782 -24.475 1.00 43.58 C \\\\nATOM 1317 CD PRO A 161 -0.924 0.562 -25.378 1.00 43.58 C \\\\nATOM 1318 N GLU A 162 2.907 1.787 -27.186 1.00 51.97 N \\\\nATOM 1319 CA GLU A 162 4.313 1.330 -27.096 1.00 51.97 C \\\\nATOM 1320 C GLU A 162 4.959 1.568 -25.708 1.00 51.97 C \\\\nATOM 1321 CB GLU A 162 5.148 2.041 -28.171 1.00 51.97 C \\\\nATOM 1322 O GLU A 162 6.053 1.091 -25.403 1.00 51.97 O \\\\nATOM 1323 CG GLU A 162 4.705 1.733 -29.611 1.00 51.97 C \\\\nATOM 1324 CD GLU A 162 5.627 2.428 -30.624 1.00 51.97 C \\\\nATOM 1325 OE1 GLU A 162 6.049 1.755 -31.589 1.00 51.97 O \\\\nATOM 1326 OE2 GLU A 162 5.927 3.624 -30.395 1.00 51.97 O \\\\nATOM 1327 N ASN A 163 4.263 2.268 -24.805 1.00 55.17 N \\\\nATOM 1328 CA ASN A 163 4.623 2.384 -23.398 1.00 55.17 C \\\\nATOM 1329 C ASN A 163 4.496 1.090 -22.566 1.00 55.17 C \\\\nATOM 1330 CB ASN A 163 3.936 3.622 -22.785 1.00 55.17 C \\\\nATOM 1331 O ASN A 163 4.902 1.119 -21.402 1.00 55.17 O \\\\nATOM 1332 CG ASN A 163 2.443 3.565 -22.528 1.00 55.17 C \\\\nATOM 1333 ND2 ASN A 163 1.793 4.704 -22.602 1.00 55.17 N \\\\nATOM 1334 OD1 ASN A 163 1.852 2.571 -22.154 1.00 55.17 O \\\\nATOM 1335 N THR A 164 4.011 -0.025 -23.135 1.00 50.75 N \\\\nATOM 1336 CA THR A 164 3.756 -1.293 -22.421 1.00 50.75 C \\\\nATOM 1337 C THR A 164 4.792 -2.411 -22.609 1.00 50.75 C \\\\nATOM 1338 CB THR A 164 2.345 -1.846 -22.708 1.00 50.75 C \\\\nATOM 1339 O THR A 164 4.489 -3.547 -22.245 1.00 50.75 O \\\\nATOM 1340 CG2 THR A 164 1.248 -0.843 -22.368 1.00 50.75 C \\\\nATOM 1341 OG1 THR A 164 2.175 -2.204 -24.057 1.00 50.75 O \\\\nATOM 1342 N ASN A 165 5.985 -2.158 -23.162 1.00 46.01 N \\\\nATOM 1343 CA ASN A 165 6.958 -3.231 -23.437 1.00 46.01 C \\\\nATOM 1344 C ASN A 165 7.416 -3.989 -22.172 1.00 46.01 C \\\\nATOM 1345 CB ASN A 165 8.159 -2.701 -24.250 1.00 46.01 C \\\\nATOM 1346 O ASN A 165 8.296 -3.539 -21.434 1.00 46.01 O \\\\nATOM 1347 CG ASN A 165 7.840 -2.535 -25.727 1.00 46.01 C \\\\nATOM 1348 ND2 ASN A 165 8.836 -2.447 -26.576 1.00 46.01 N \\\\nATOM 1349 OD1 ASN A 165 6.696 -2.500 -26.135 1.00 46.01 O \\\\nATOM 1350 N PHE A 166 6.859 -5.189 -21.983 1.00 39.23 N \\\\nATOM 1351 CA PHE A 166 7.439 -6.247 -21.160 1.00 39.23 C \\\\nATOM 1352 C PHE A 166 8.686 -6.815 -21.859 1.00 39.23 C \\\\nATOM 1353 CB PHE A 166 6.422 -7.383 -20.959 1.00 39.23 C \\\\nATOM 1354 O PHE A 166 8.648 -7.028 -23.072 1.00 39.23 O \\\\nATOM 1355 CG PHE A 166 5.298 -7.094 -19.983 1.00 39.23 C \\\\nATOM 1356 CD1 PHE A 166 5.477 -7.366 -18.612 1.00 39.23 C \\\\nATOM 1357 CD2 PHE A 166 4.061 -6.601 -20.440 1.00 39.23 C \\\\nATOM 1358 CE1 PHE A 166 4.427 -7.142 -17.704 1.00 39.23 C \\\\nATOM 1359 CE2 PHE A 166 3.004 -6.398 -19.533 1.00 39.23 C \\\\nATOM 1360 CZ PHE A 166 3.188 -6.666 -18.165 1.00 39.23 C \\\\nATOM 1361 N PRO A 167 9.773 -7.129 -21.133 1.00 38.71 N \\\\nATOM 1362 CA PRO A 167 10.925 -7.804 -21.715 1.00 38.71 C \\\\nATOM 1363 C PRO A 167 10.655 -9.311 -21.872 1.00 38.71 C \\\\nATOM 1364 CB PRO A 167 12.089 -7.465 -20.778 1.00 38.71 C \\\\nATOM 1365 O PRO A 167 11.086 -10.120 -21.052 1.00 38.71 O \\\\nATOM 1366 CG PRO A 167 11.413 -7.359 -19.411 1.00 38.71 C \\\\nATOM 1367 CD PRO A 167 10.026 -6.799 -19.738 1.00 38.71 C \\\\nATOM 1368 N ALA A 168 9.985 -9.694 -22.961 1.00 35.78 N \\\\nATOM 1369 CA ALA A 168 10.348 -10.935 -23.644 1.00 35.78 C \\\\nATOM 1370 C ALA A 168 11.684 -10.665 -24.361 1.00 35.78 C \\\\nATOM 1371 CB ALA A 168 9.221 -11.358 -24.591 1.00 35.78 C \\\\nATOM 1372 O ALA A 168 11.835 -9.631 -25.011 1.00 35.78 O \\\\nATOM 1373 N GLY A 169 12.697 -11.498 -24.123 1.00 29.87 N \\\\nATOM 1374 CA GLY A 169 14.087 -11.107 -24.379 1.00 29.87 C \\\\nATOM 1375 C GLY A 169 14.470 -11.009 -25.859 1.00 29.87 C \\\\nATOM 1376 O GLY A 169 14.032 -11.835 -26.648 1.00 29.87 O \\\\nATOM 1377 N ILE A 170 15.332 -10.035 -26.181 1.00 36.65 N \\\\nATOM 1378 CA ILE A 170 16.510 -10.086 -27.078 1.00 36.65 C \\\\nATOM 1379 C ILE A 170 17.256 -8.728 -26.959 1.00 36.65 C \\\\nATOM 1380 CB ILE A 170 16.148 -10.534 -28.525 1.00 36.65 C \\\\nATOM 1381 O ILE A 170 16.703 -7.734 -26.495 1.00 36.65 O \\\\nATOM 1382 CG1 ILE A 170 16.237 -12.082 -28.648 1.00 36.65 C \\\\nATOM 1383 CG2 ILE A 170 17.054 -9.959 -29.631 1.00 36.65 C \\\\nATOM 1384 CD1 ILE A 170 15.229 -12.665 -29.647 1.00 36.65 C \\\\nATOM 1385 N GLU A 171 18.553 -8.749 -27.253 1.00 33.34 N \\\\nATOM 1386 CA GLU A 171 19.647 -7.827 -26.886 1.00 33.34 C \\\\nATOM 1387 C GLU A 171 19.508 -6.322 -27.262 1.00 33.34 C \\\\nATOM 1388 CB GLU A 171 20.912 -8.384 -27.563 1.00 33.34 C \\\\nATOM 1389 O GLU A 171 18.815 -5.979 -28.219 1.00 33.34 O \\\\nATOM 1390 CG GLU A 171 21.205 -9.850 -27.182 1.00 33.34 C \\\\nATOM 1391 CD GLU A 171 22.413 -10.424 -27.929 1.00 33.34 C \\\\nATOM 1392 OE1 GLU A 171 23.174 -11.173 -27.278 1.00 33.34 O \\\\nATOM 1393 OE2 GLU A 171 22.553 -10.127 -29.136 1.00 33.34 O \\\\nATOM 1394 N PRO A 172 20.211 -5.394 -26.564 1.00 32.49 N \\\\nATOM 1395 CA PRO A 172 20.148 -3.952 -26.836 1.00 32.49 C \\\\nATOM 1396 C PRO A 172 21.300 -3.415 -27.713 1.00 32.49 C \\\\nATOM 1397 CB PRO A 172 20.199 -3.318 -25.443 1.00 32.49 C \\\\nATOM 1398 O PRO A 172 22.469 -3.712 -27.466 1.00 32.49 O \\\\nATOM 1399 CG PRO A 172 21.162 -4.236 -24.683 1.00 32.49 C \\\\nATOM 1400 CD PRO A 172 20.926 -5.616 -25.309 1.00 32.49 C \\\\nATOM 1401 N GLN A 173 21.001 -2.487 -28.635 1.00 36.11 N \\\\nATOM 1402 CA GLN A 173 22.011 -1.656 -29.317 1.00 36.11 C \\\\nATOM 1403 C GLN A 173 21.726 -0.141 -29.211 1.00 36.11 C \\\\nATOM 1404 CB GLN A 173 22.234 -2.115 -30.772 1.00 36.11 C \\\\nATOM 1405 O GLN A 173 20.910 0.426 -29.924 1.00 36.11 O \\\\nATOM 1406 CG GLN A 173 23.064 -3.412 -30.836 1.00 36.11 C \\\\nATOM 1407 CD GLN A 173 23.549 -3.774 -32.240 1.00 36.11 C \\\\nATOM 1408 NE2 GLN A 173 24.380 -4.785 -32.370 1.00 36.11 N \\\\nATOM 1409 OE1 GLN A 173 23.215 -3.168 -33.243 1.00 36.11 O \\\\nATOM 1410 N SER A 174 22.463 0.497 -28.294 1.00 35.78 N \\\\nATOM 1411 CA SER A 174 23.201 1.768 -28.464 1.00 35.78 C \\\\nATOM 1412 C SER A 174 22.584 3.014 -29.161 1.00 35.78 C \\\\nATOM 1413 CB SER A 174 24.544 1.424 -29.129 1.00 35.78 C \\\\nATOM 1414 O SER A 174 22.504 3.069 -30.383 1.00 35.78 O \\\\nATOM 1415 OG SER A 174 24.359 0.851 -30.404 1.00 35.78 O \\\\nATOM 1416 N ASN A 175 22.484 4.104 -28.369 1.00 35.08 N \\\\nATOM 1417 CA ASN A 175 23.258 5.374 -28.501 1.00 35.08 C \\\\nATOM 1418 C ASN A 175 22.610 6.746 -28.897 1.00 35.08 C \\\\nATOM 1419 CB ASN A 175 24.603 5.154 -29.250 1.00 35.08 C \\\\nATOM 1420 O ASN A 175 22.404 7.013 -30.071 1.00 35.08 O \\\\nATOM 1421 CG ASN A 175 25.726 4.615 -28.377 1.00 35.08 C \\\\nATOM 1422 ND2 ASN A 175 26.864 4.315 -28.954 1.00 35.08 N \\\\nATOM 1423 OD1 ASN A 175 25.602 4.449 -27.175 1.00 35.08 O \\\\nATOM 1424 N ILE A 176 22.622 7.684 -27.909 1.00 42.21 N \\\\nATOM 1425 CA ILE A 176 23.071 9.121 -27.980 1.00 42.21 C \\\\nATOM 1426 C ILE A 176 22.116 10.155 -28.683 1.00 42.21 C \\\\nATOM 1427 CB ILE A 176 24.533 9.124 -28.560 1.00 42.21 C \\\\nATOM 1428 O ILE A 176 21.554 9.825 -29.717 1.00 42.21 O \\\\nATOM 1429 CG1 ILE A 176 25.528 8.202 -27.803 1.00 42.21 C \\\\nATOM 1430 CG2 ILE A 176 25.248 10.481 -28.601 1.00 42.21 C \\\\nATOM 1431 CD1 ILE A 176 26.821 7.896 -28.587 1.00 42.21 C \\\\nATOM 1432 N PRO A 177 21.984 11.451 -28.260 1.00 34.10 N \\\\nATOM 1433 CA PRO A 177 21.878 12.076 -26.925 1.00 34.10 C \\\\nATOM 1434 C PRO A 177 20.748 13.164 -26.840 1.00 34.10 C \\\\nATOM 1435 CB PRO A 177 23.238 12.758 -26.772 1.00 34.10 C \\\\nATOM 1436 O PRO A 177 19.832 13.216 -27.651 1.00 34.10 O \\\\nATOM 1437 CG PRO A 177 23.430 13.356 -28.173 1.00 34.10 C \\\\nATOM 1438 CD PRO A 177 22.508 12.528 -29.094 1.00 34.10 C \\\\nATOM 1439 N GLU A 178 20.803 14.056 -25.840 1.00 31.22 N \\\\nATOM 1440 CA GLU A 178 19.766 15.049 -25.493 1.00 31.22 C \\\\nATOM 1441 C GLU A 178 19.873 16.441 -26.160 1.00 31.22 C \\\\nATOM 1442 CB GLU A 178 19.800 15.310 -23.972 1.00 31.22 C \\\\nATOM 1443 O GLU A 178 20.954 17.024 -26.197 1.00 31.22 O \\\\nATOM 1444 CG GLU A 178 19.939 14.061 -23.097 1.00 31.22 C \\\\nATOM 1445 CD GLU A 178 19.667 14.394 -21.630 1.00 31.22 C \\\\nATOM 1446 OE1 GLU A 178 18.475 14.276 -21.249 1.00 31.22 O \\\\nATOM 1447 OE2 GLU A 178 20.612 14.760 -20.908 1.00 31.22 O \\\\nATOM 1448 N THR A 179 18.718 17.054 -26.467 1.00 36.45 N \\\\nATOM 1449 CA THR A 179 18.493 18.520 -26.512 1.00 36.45 C \\\\nATOM 1450 C THR A 179 17.057 18.880 -26.052 1.00 36.45 C \\\\nATOM 1451 CB THR A 179 18.724 19.135 -27.909 1.00 36.45 C \\\\nATOM 1452 O THR A 179 16.109 18.175 -26.403 1.00 36.45 O \\\\nATOM 1453 CG2 THR A 179 20.193 19.431 -28.204 1.00 36.45 C \\\\nATOM 1454 OG1 THR A 179 18.255 18.284 -28.926 1.00 36.45 O \\\\nATOM 1455 N PRO A 180 16.865 19.933 -25.227 1.00 38.72 N \\\\nATOM 1456 CA PRO A 180 15.547 20.523 -24.897 1.00 38.72 C \\\\nATOM 1457 C PRO A 180 15.526 22.074 -25.039 1.00 38.72 C \\\\nATOM 1458 CB PRO A 180 15.411 20.132 -23.420 1.00 38.72 C \\\\nATOM 1459 O PRO A 180 16.585 22.664 -25.249 1.00 38.72 O \\\\nATOM 1460 CG PRO A 180 16.821 20.396 -22.876 1.00 38.72 C \\\\nATOM 1461 CD PRO A 180 17.742 20.136 -24.075 1.00 38.72 C \\\\nATOM 1462 N PRO A 181 14.425 22.785 -24.695 1.00 44.75 N \\\\nATOM 1463 CA PRO A 181 12.998 22.573 -24.970 1.00 44.75 C \\\\nATOM 1464 C PRO A 181 12.578 23.642 -26.037 1.00 44.75 C \\\\nATOM 1465 CB PRO A 181 12.406 22.621 -23.564 1.00 44.75 C \\\\nATOM 1466 O PRO A 181 13.211 23.555 -27.088 1.00 44.75 O \\\\nATOM 1467 CG PRO A 181 13.195 23.757 -22.893 1.00 44.75 C \\\\nATOM 1468 CD PRO A 181 14.509 23.832 -23.686 1.00 44.75 C \\\\nATOM 1469 N PRO A 182 11.679 24.667 -25.892 1.00 38.69 N \\\\nATOM 1470 CA PRO A 182 10.580 25.008 -24.958 1.00 38.69 C \\\\nATOM 1471 C PRO A 182 9.177 24.739 -25.580 1.00 38.69 C \\\\nATOM 1472 CB PRO A 182 10.839 26.493 -24.650 1.00 38.69 C \\\\nATOM 1473 O PRO A 182 9.040 23.844 -26.406 1.00 38.69 O \\\\nATOM 1474 CG PRO A 182 11.386 27.063 -25.956 1.00 38.69 C \\\\nATOM 1475 CD PRO A 182 11.791 25.833 -26.773 1.00 38.69 C \\\\nATOM 1476 N GLY A 183 8.136 25.483 -25.169 1.00 30.01 N \\\\nATOM 1477 CA GLY A 183 6.812 25.582 -25.824 1.00 30.01 C \\\\nATOM 1478 C GLY A 183 6.240 27.004 -25.675 1.00 30.01 C \\\\nATOM 1479 O GLY A 183 6.944 27.820 -25.092 1.00 30.01 O \\\\nATOM 1480 N TYR A 184 5.022 27.310 -26.155 1.00 39.51 N \\\\nATOM 1481 CA TYR A 184 4.191 28.473 -25.752 1.00 39.51 C \\\\nATOM 1482 C TYR A 184 2.738 28.354 -26.304 1.00 39.51 C \\\\nATOM 1483 CB TYR A 184 4.832 29.829 -26.159 1.00 39.51 C \\\\nATOM 1484 O TYR A 184 2.514 27.690 -27.308 1.00 39.51 O \\\\nATOM 1485 CG TYR A 184 5.058 30.825 -25.014 1.00 39.51 C \\\\nATOM 1486 CD1 TYR A 184 4.208 31.938 -24.856 1.00 39.51 C \\\\nATOM 1487 CD2 TYR A 184 6.147 30.684 -24.126 1.00 39.51 C \\\\nATOM 1488 CE1 TYR A 184 4.418 32.858 -23.805 1.00 39.51 C \\\\nATOM 1489 CE2 TYR A 184 6.360 31.588 -23.072 1.00 39.51 C \\\\nATOM 1490 OH TYR A 184 5.701 33.561 -21.892 1.00 39.51 O \\\\nATOM 1491 CZ TYR A 184 5.489 32.680 -22.905 1.00 39.51 C \\\\nATOM 1492 N LEU A 185 1.807 28.987 -25.580 1.00 35.19 N \\\\nATOM 1493 CA LEU A 185 0.381 29.350 -25.789 1.00 35.19 C \\\\nATOM 1494 C LEU A 185 -0.415 29.022 -27.091 1.00 35.19 C \\\\nATOM 1495 CB LEU A 185 0.305 30.876 -25.571 1.00 35.19 C \\\\nATOM 1496 O LEU A 185 -0.010 29.385 -28.186 1.00 35.19 O \\\\nATOM 1497 CG LEU A 185 0.771 31.371 -24.187 1.00 35.19 C \\\\nATOM 1498 CD1 LEU A 185 0.821 32.896 -24.155 1.00 35.19 C \\\\nATOM 1499 CD2 LEU A 185 -0.152 30.898 -23.064 1.00 35.19 C \\\\nATOM 1500 N SER A 186 -1.622 28.473 -26.858 1.00 34.39 N \\\\nATOM 1501 CA SER A 186 -2.988 28.878 -27.296 1.00 34.39 C \\\\nATOM 1502 C SER A 186 -3.303 29.479 -28.681 1.00 34.39 C \\\\nATOM 1503 CB SER A 186 -3.534 29.907 -26.294 1.00 34.39 C \\\\nATOM 1504 O SER A 186 -2.736 30.504 -29.031 1.00 34.39 O \\\\nATOM 1505 OG SER A 186 -3.317 29.516 -24.945 1.00 34.39 O \\\\nATOM 1506 N GLU A 187 -4.399 29.001 -29.302 1.00 39.49 N \\\\nATOM 1507 CA GLU A 187 -5.525 29.837 -29.798 1.00 39.49 C \\\\nATOM 1508 C GLU A 187 -6.809 29.001 -30.054 1.00 39.49 C \\\\nATOM 1509 CB GLU A 187 -5.139 30.702 -31.023 1.00 39.49 C \\\\nATOM 1510 O GLU A 187 -6.735 27.781 -30.217 1.00 39.49 O \\\\nATOM 1511 CG GLU A 187 -5.129 32.188 -30.606 1.00 39.49 C \\\\nATOM 1512 CD GLU A 187 -4.650 33.164 -31.695 1.00 39.49 C \\\\nATOM 1513 OE1 GLU A 187 -5.250 34.262 -31.783 1.00 39.49 O \\\\nATOM 1514 OE2 GLU A 187 -3.662 32.854 -32.400 1.00 39.49 O \\\\nATOM 1515 N ASP A 188 -7.981 29.651 -30.011 1.00 34.92 N \\\\nATOM 1516 CA ASP A 188 -9.330 29.047 -29.984 1.00 34.92 C \\\\nATOM 1517 C ASP A 188 -9.981 28.853 -31.376 1.00 34.92 C \\\\nATOM 1518 CB ASP A 188 -10.245 29.934 -29.116 1.00 34.92 C \\\\nATOM 1519 O ASP A 188 -9.538 29.415 -32.378 1.00 34.92 O \\\\nATOM 1520 CG ASP A 188 -9.788 30.022 -27.658 1.00 34.92 C \\\\nATOM 1521 OD1 ASP A 188 -9.987 29.023 -26.931 1.00 34.92 O \\\\nATOM 1522 OD2 ASP A 188 -9.236 31.080 -27.276 1.00 34.92 O \\\\nATOM 1523 N GLY A 189 -11.098 28.109 -31.437 1.00 37.79 N \\\\nATOM 1524 CA GLY A 189 -11.931 27.992 -32.644 1.00 37.79 C \\\\nATOM 1525 C GLY A 189 -13.313 27.363 -32.408 1.00 37.79 C \\\\nATOM 1526 O GLY A 189 -13.435 26.143 -32.331 1.00 37.79 O \\\\nATOM 1527 N GLU A 190 -14.361 28.192 -32.341 1.00 33.29 N \\\\nATOM 1528 CA GLU A 190 -15.779 27.783 -32.283 1.00 33.29 C \\\\nATOM 1529 C GLU A 190 -16.458 27.848 -33.669 1.00 33.29 C \\\\nATOM 1530 CB GLU A 190 -16.569 28.709 -31.334 1.00 33.29 C \\\\nATOM 1531 O GLU A 190 -16.091 28.687 -34.487 1.00 33.29 O \\\\nATOM 1532 CG GLU A 190 -16.107 28.723 -29.870 1.00 33.29 C \\\\nATOM 1533 CD GLU A 190 -17.007 29.639 -29.018 1.00 33.29 C \\\\nATOM 1534 OE1 GLU A 190 -17.574 29.139 -28.019 1.00 33.29 O \\\\nATOM 1535 OE2 GLU A 190 -17.140 30.831 -29.380 1.00 33.29 O \\\\nATOM 1536 N THR A 191 -17.458 26.990 -33.929 1.00 42.71 N \\\\nATOM 1537 CA THR A 191 -18.598 27.103 -34.895 1.00 42.71 C \\\\nATOM 1538 C THR A 191 -19.276 25.716 -35.016 1.00 42.71 C \\\\nATOM 1539 CB THR A 191 -18.207 27.533 -36.336 1.00 42.71 C \\\\nATOM 1540 O THR A 191 -18.584 24.710 -34.902 1.00 42.71 O \\\\nATOM 1541 CG2 THR A 191 -18.196 29.048 -36.589 1.00 42.71 C \\\\nATOM 1542 OG1 THR A 191 -16.938 27.058 -36.710 1.00 42.71 O \\\\nATOM 1543 N SER A 192 -20.579 25.502 -35.263 1.00 40.70 N \\\\nATOM 1544 CA SER A 192 -21.818 26.304 -35.160 1.00 40.70 C \\\\nATOM 1545 C SER A 192 -23.040 25.348 -35.172 1.00 40.70 C \\\\nATOM 1546 CB SER A 192 -21.980 27.261 -36.348 1.00 40.70 C \\\\nATOM 1547 O SER A 192 -22.941 24.232 -35.679 1.00 40.70 O \\\\nATOM 1548 OG SER A 192 -21.283 28.465 -36.112 1.00 40.70 O \\\\nATOM 1549 N ASP A 193 -24.191 25.782 -34.643 1.00 32.70 N \\\\nATOM 1550 CA ASP A 193 -25.446 25.002 -34.558 1.00 32.70 C \\\\nATOM 1551 C ASP A 193 -26.161 24.721 -35.895 1.00 32.70 C \\\\nATOM 1552 CB ASP A 193 -26.463 25.781 -33.704 1.00 32.70 C \\\\nATOM 1553 O ASP A 193 -26.122 25.534 -36.818 1.00 32.70 O \\\\nATOM 1554 CG ASP A 193 -26.155 25.743 -32.216 1.00 32.70 C \\\\nATOM 1555 OD1 ASP A 193 -26.245 24.629 -31.656 1.00 32.70 O \\\\nATOM 1556 OD2 ASP A 193 -25.885 26.830 -31.664 1.00 32.70 O \\\\nATOM 1557 N HIS A 194 -26.991 23.664 -35.917 1.00 43.62 N \\\\nATOM 1558 CA HIS A 194 -28.169 23.580 -36.797 1.00 43.62 C \\\\nATOM 1559 C HIS A 194 -29.393 22.927 -36.111 1.00 43.62 C \\\\nATOM 1560 CB HIS A 194 -27.822 22.876 -38.123 1.00 43.62 C \\\\nATOM 1561 O HIS A 194 -29.395 21.740 -35.792 1.00 43.62 O \\\\nATOM 1562 CG HIS A 194 -27.307 23.818 -39.187 1.00 43.62 C \\\\nATOM 1563 CD2 HIS A 194 -26.093 23.766 -39.821 1.00 43.62 C \\\\nATOM 1564 ND1 HIS A 194 -27.980 24.906 -39.701 1.00 43.62 N \\\\nATOM 1565 CE1 HIS A 194 -27.186 25.497 -40.608 1.00 43.62 C \\\\nATOM 1566 NE2 HIS A 194 -26.036 24.823 -40.740 1.00 43.62 N \\\\nATOM 1567 N GLN A 195 -30.471 23.707 -35.955 1.00 34.38 N \\\\nATOM 1568 CA GLN A 195 -31.841 23.260 -35.637 1.00 34.38 C \\\\nATOM 1569 C GLN A 195 -32.716 23.226 -36.901 1.00 34.38 C \\\\nATOM 1570 CB GLN A 195 -32.523 24.269 -34.690 1.00 34.38 C \\\\nATOM 1571 O GLN A 195 -32.548 24.103 -37.742 1.00 34.38 O \\\\nATOM 1572 CG GLN A 195 -32.220 24.116 -33.198 1.00 34.38 C \\\\nATOM 1573 CD GLN A 195 -32.992 25.136 -32.354 1.00 34.38 C \\\\nATOM 1574 NE2 GLN A 195 -32.890 25.070 -31.046 1.00 34.38 N \\\\nATOM 1575 OE1 GLN A 195 -33.706 26.001 -32.834 1.00 34.38 O \\\\nATOM 1576 N MET A 196 -33.689 22.298 -36.971 1.00 43.58 N \\\\nATOM 1577 CA MET A 196 -34.997 22.344 -37.686 1.00 43.58 C \\\\nATOM 1578 C MET A 196 -35.638 20.930 -37.660 1.00 43.58 C \\\\nATOM 1579 CB MET A 196 -34.835 22.770 -39.167 1.00 43.58 C \\\\nATOM 1580 O MET A 196 -34.898 19.954 -37.655 1.00 43.58 O \\\\nATOM 1581 CG MET A 196 -34.842 24.298 -39.367 1.00 43.58 C \\\\nATOM 1582 SD MET A 196 -36.152 24.997 -40.407 1.00 43.58 S \\\\nATOM 1583 CE MET A 196 -35.694 26.747 -40.262 1.00 43.58 C \\\\nATOM 1584 N ASN A 197 -36.958 20.690 -37.705 1.00 41.11 N \\\\nATOM 1585 CA ASN A 197 -38.153 21.466 -37.322 1.00 41.11 C \\\\nATOM 1586 C ASN A 197 -39.364 20.485 -37.186 1.00 41.11 C \\\\nATOM 1587 CB ASN A 197 -38.439 22.571 -38.361 1.00 41.11 C \\\\nATOM 1588 O ASN A 197 -39.254 19.313 -37.540 1.00 41.11 O \\\\nATOM 1589 CG ASN A 197 -39.298 23.710 -37.834 1.00 41.11 C \\\\nATOM 1590 ND2 ASN A 197 -39.465 24.753 -38.609 1.00 41.11 N \\\\nATOM 1591 OD1 ASN A 197 -39.813 23.690 -36.728 1.00 41.11 O \\\\nATOM 1592 N HIS A 198 -40.511 20.944 -36.673 1.00 40.12 N \\\\nATOM 1593 CA HIS A 198 -41.731 20.157 -36.393 1.00 40.12 C \\\\nATOM 1594 C HIS A 198 -42.478 19.583 -37.619 1.00 40.12 C \\\\nATOM 1595 CB HIS A 198 -42.733 21.089 -35.691 1.00 40.12 C \\\\nATOM 1596 O HIS A 198 -42.436 20.176 -38.696 1.00 40.12 O \\\\nATOM 1597 CG HIS A 198 -42.362 21.505 -34.298 1.00 40.12 C \\\\nATOM 1598 CD2 HIS A 198 -41.690 22.640 -33.929 1.00 40.12 C \\\\nATOM 1599 ND1 HIS A 198 -42.742 20.860 -33.143 1.00 40.12 N \\\\nATOM 1600 CE1 HIS A 198 -42.304 21.586 -32.102 1.00 40.12 C \\\\nATOM 1601 NE2 HIS A 198 -41.659 22.679 -32.531 1.00 40.12 N \\\\nATOM 1602 N SER A 199 -43.319 18.552 -37.397 1.00 44.95 N \\\\nATOM 1603 CA SER A 199 -44.767 18.530 -37.752 1.00 44.95 C \\\\nATOM 1604 C SER A 199 -45.504 17.297 -37.184 1.00 44.95 C \\\\nATOM 1605 CB SER A 199 -45.013 18.600 -39.264 1.00 44.95 C \\\\nATOM 1606 O SER A 199 -44.880 16.278 -36.905 1.00 44.95 O \\\\nATOM 1607 OG SER A 199 -44.858 19.940 -39.677 1.00 44.95 O \\\\nATOM 1608 N MET A 200 -46.827 17.399 -36.996 1.00 45.79 N \\\\nATOM 1609 CA MET A 200 -47.737 16.340 -36.510 1.00 45.79 C \\\\nATOM 1610 C MET A 200 -48.777 15.996 -37.591 1.00 45.79 C \\\\nATOM 1611 CB MET A 200 -48.544 16.849 -35.293 1.00 45.79 C \\\\nATOM 1612 O MET A 200 -49.139 16.913 -38.320 1.00 45.79 O \\\\nATOM 1613 CG MET A 200 -47.745 17.422 -34.119 1.00 45.79 C \\\\nATOM 1614 SD MET A 200 -48.821 18.013 -32.777 1.00 45.79 S \\\\nATOM 1615 CE MET A 200 -47.596 18.699 -31.636 1.00 45.79 C \\\\nATOM 1616 N ASP A 201 -49.331 14.771 -37.623 1.00 46.67 N \\\\nATOM 1617 CA ASP A 201 -50.800 14.576 -37.689 1.00 46.67 C \\\\nATOM 1618 C ASP A 201 -51.266 13.129 -37.369 1.00 46.67 C \\\\nATOM 1619 CB ASP A 201 -51.455 15.079 -38.999 1.00 46.67 C \\\\nATOM 1620 O ASP A 201 -50.450 12.229 -37.159 1.00 46.67 O \\\\nATOM 1621 CG ASP A 201 -52.680 15.954 -38.674 1.00 46.67 C \\\\nATOM 1622 OD1 ASP A 201 -53.380 15.616 -37.687 1.00 46.67 O \\\\nATOM 1623 OD2 ASP A 201 -52.926 16.935 -39.408 1.00 46.67 O \\\\nATOM 1624 N ALA A 202 -52.585 12.935 -37.251 1.00 43.71 N \\\\nATOM 1625 CA ALA A 202 -53.251 11.820 -36.563 1.00 43.71 C \\\\nATOM 1626 C ALA A 202 -53.674 10.601 -37.424 1.00 43.71 C \\\\nATOM 1627 CB ALA A 202 -54.477 12.426 -35.864 1.00 43.71 C \\\\nATOM 1628 O ALA A 202 -53.850 10.694 -38.636 1.00 43.71 O \\\\nATOM 1629 N GLY A 203 -53.959 9.462 -36.762 1.00 40.70 N \\\\nATOM 1630 CA GLY A 203 -54.671 8.322 -37.373 1.00 40.70 C \\\\nATOM 1631 C GLY A 203 -54.584 6.979 -36.622 1.00 40.70 C \\\\nATOM 1632 O GLY A 203 -53.621 6.241 -36.779 1.00 40.70 O \\\\nATOM 1633 N SER A 204 -55.635 6.626 -35.875 1.00 42.76 N \\\\nATOM 1634 CA SER A 204 -55.953 5.263 -35.375 1.00 42.76 C \\\\nATOM 1635 C SER A 204 -57.215 4.749 -36.114 1.00 42.76 C \\\\nATOM 1636 CB SER A 204 -56.175 5.346 -33.854 1.00 42.76 C \\\\nATOM 1637 O SER A 204 -57.909 5.613 -36.658 1.00 42.76 O \\\\nATOM 1638 OG SER A 204 -54.953 5.182 -33.165 1.00 42.76 O \\\\nATOM 1639 N PRO A 205 -57.600 3.440 -36.129 1.00 46.18 N \\\\nATOM 1640 CA PRO A 205 -57.311 2.419 -35.103 1.00 46.18 C \\\\nATOM 1641 C PRO A 205 -57.072 0.946 -35.563 1.00 46.18 C \\\\nATOM 1642 CB PRO A 205 -58.634 2.448 -34.321 1.00 46.18 C \\\\nATOM 1643 O PRO A 205 -57.305 0.567 -36.703 1.00 46.18 O \\\\nATOM 1644 CG PRO A 205 -59.689 2.523 -35.436 1.00 46.18 C \\\\nATOM 1645 CD PRO A 205 -58.931 3.098 -36.637 1.00 46.18 C \\\\nATOM 1646 N ASN A 206 -56.707 0.107 -34.579 1.00 39.37 N \\\\nATOM 1647 CA ASN A 206 -57.019 -1.327 -34.383 1.00 39.37 C \\\\nATOM 1648 C ASN A 206 -57.092 -2.311 -35.573 1.00 39.37 C \\\\nATOM 1649 CB ASN A 206 -58.360 -1.430 -33.622 1.00 39.37 C \\\\nATOM 1650 O ASN A 206 -58.089 -2.336 -36.285 1.00 39.37 O \\\\nATOM 1651 CG ASN A 206 -58.338 -0.871 -32.217 1.00 39.37 C \\\\nATOM 1652 ND2 ASN A 206 -59.478 -0.807 -31.571 1.00 39.37 N \\\\nATOM 1653 OD1 ASN A 206 -57.317 -0.484 -31.679 1.00 39.37 O \\\\nATOM 1654 N LEU A 207 -56.196 -3.312 -35.564 1.00 44.78 N \\\\nATOM 1655 CA LEU A 207 -56.487 -4.720 -35.904 1.00 44.78 C \\\\nATOM 1656 C LEU A 207 -55.433 -5.648 -35.248 1.00 44.78 C \\\\nATOM 1657 CB LEU A 207 -56.518 -4.928 -37.441 1.00 44.78 C \\\\nATOM 1658 O LEU A 207 -54.266 -5.622 -35.625 1.00 44.78 O \\\\nATOM 1659 CG LEU A 207 -57.917 -4.971 -38.099 1.00 44.78 C \\\\nATOM 1660 CD1 LEU A 207 -57.771 -4.972 -39.620 1.00 44.78 C \\\\nATOM 1661 CD2 LEU A 207 -58.716 -6.216 -37.699 1.00 44.78 C \\\\nATOM 1662 N SER A 208 -55.842 -6.478 -34.284 1.00 40.73 N \\\\nATOM 1663 CA SER A 208 -55.055 -7.621 -33.762 1.00 40.73 C \\\\nATOM 1664 C SER A 208 -55.432 -8.888 -34.557 1.00 40.73 C \\\\nATOM 1665 CB SER A 208 -55.324 -7.826 -32.261 1.00 40.73 C \\\\nATOM 1666 O SER A 208 -56.579 -8.945 -35.011 1.00 40.73 O \\\\nATOM 1667 OG SER A 208 -55.350 -6.605 -31.544 1.00 40.73 O \\\\nATOM 1668 N PRO A 209 -54.570 -9.926 -34.702 1.00 44.83 N \\\\nATOM 1669 CA PRO A 209 -54.400 -10.888 -33.596 1.00 44.83 C \\\\nATOM 1670 C PRO A 209 -53.067 -11.690 -33.521 1.00 44.83 C \\\\nATOM 1671 CB PRO A 209 -55.548 -11.872 -33.862 1.00 44.83 C \\\\nATOM 1672 O PRO A 209 -52.260 -11.716 -34.441 1.00 44.83 O \\\\nATOM 1673 CG PRO A 209 -55.517 -12.030 -35.384 1.00 44.83 C \\\\nATOM 1674 CD PRO A 209 -54.779 -10.779 -35.876 1.00 44.83 C \\\\nATOM 1675 N ASN A 210 -52.975 -12.466 -32.431 1.00 41.10 N \\\\nATOM 1676 CA ASN A 210 -52.140 -13.654 -32.163 1.00 41.10 C \\\\nATOM 1677 C ASN A 210 -50.635 -13.492 -31.825 1.00 41.10 C \\\\nATOM 1678 CB ASN A 210 -52.397 -14.760 -33.202 1.00 41.10 C \\\\nATOM 1679 O ASN A 210 -49.853 -13.017 -32.644 1.00 41.10 O \\\\nATOM 1680 CG ASN A 210 -53.775 -15.385 -33.076 1.00 41.10 C \\\\nATOM 1681 ND2 ASN A 210 -54.098 -16.329 -33.926 1.00 41.10 N \\\\nATOM 1682 OD1 ASN A 210 -54.574 -15.061 -32.210 1.00 41.10 O \\\\nATOM 1683 N PRO A 211 -50.195 -13.989 -30.644 1.00 40.72 N \\\\nATOM 1684 CA PRO A 211 -48.784 -14.075 -30.279 1.00 40.72 C \\\\nATOM 1685 C PRO A 211 -48.138 -15.368 -30.802 1.00 40.72 C \\\\nATOM 1686 CB PRO A 211 -48.777 -14.031 -28.748 1.00 40.72 C \\\\nATOM 1687 O PRO A 211 -48.693 -16.457 -30.648 1.00 40.72 O \\\\nATOM 1688 CG PRO A 211 -50.056 -14.780 -28.371 1.00 40.72 C \\\\nATOM 1689 CD PRO A 211 -51.010 -14.460 -29.524 1.00 40.72 C \\\\nATOM 1690 N MET A 212 -46.921 -15.265 -31.338 1.00 42.15 N \\\\nATOM 1691 CA MET A 212 -46.016 -16.412 -31.467 1.00 42.15 C \\\\nATOM 1692 C MET A 212 -45.120 -16.483 -30.229 1.00 42.15 C \\\\nATOM 1693 CB MET A 212 -45.197 -16.341 -32.766 1.00 42.15 C \\\\nATOM 1694 O MET A 212 -44.534 -15.481 -29.822 1.00 42.15 O \\\\nATOM 1695 CG MET A 212 -46.095 -16.597 -33.984 1.00 42.15 C \\\\nATOM 1696 SD MET A 212 -45.256 -16.690 -35.591 1.00 42.15 S \\\\nATOM 1697 CE MET A 212 -44.234 -18.174 -35.381 1.00 42.15 C \\\\nATOM 1698 N SER A 213 -45.035 -17.666 -29.621 1.00 39.51 N \\\\nATOM 1699 CA SER A 213 -44.201 -17.926 -28.446 1.00 39.51 C \\\\nATOM 1700 C SER A 213 -42.723 -17.623 -28.732 1.00 39.51 C \\\\nATOM 1701 CB SER A 213 -44.315 -19.400 -28.044 1.00 39.51 C \\\\nATOM 1702 O SER A 213 -42.234 -18.034 -29.788 1.00 39.51 O \\\\nATOM 1703 OG SER A 213 -45.673 -19.802 -27.981 1.00 39.51 O \\\\nATOM 1704 N PRO A 214 -41.972 -16.991 -27.810 1.00 42.72 N \\\\nATOM 1705 CA PRO A 214 -40.527 -16.881 -27.955 1.00 42.72 C \\\\nATOM 1706 C PRO A 214 -39.909 -18.278 -27.898 1.00 42.72 C \\\\nATOM 1707 CB PRO A 214 -40.030 -16.000 -26.800 1.00 42.72 C \\\\nATOM 1708 O PRO A 214 -40.210 -19.057 -26.990 1.00 42.72 O \\\\nATOM 1709 CG PRO A 214 -41.299 -15.382 -26.214 1.00 42.72 C \\\\nATOM 1710 CD PRO A 214 -42.392 -16.393 -26.555 1.00 42.72 C \\\\nATOM 1711 N ALA A 215 -39.018 -18.593 -28.837 1.00 38.54 N \\\\nATOM 1712 CA ALA A 215 -38.164 -19.761 -28.699 1.00 38.54 C \\\\nATOM 1713 C ALA A 215 -37.263 -19.558 -27.471 1.00 38.54 C \\\\nATOM 1714 CB ALA A 215 -37.366 -19.964 -29.993 1.00 38.54 C \\\\nATOM 1715 O ALA A 215 -36.411 -18.668 -27.457 1.00 38.54 O \\\\nATOM 1716 N HIS A 216 -37.455 -20.375 -26.433 1.00 40.42 N \\\\nATOM 1717 CA HIS A 216 -36.520 -20.447 -25.316 1.00 40.42 C \\\\nATOM 1718 C HIS A 216 -35.209 -21.071 -25.806 1.00 40.42 C \\\\nATOM 1719 CB HIS A 216 -37.123 -21.222 -24.129 1.00 40.42 C \\\\nATOM 1720 O HIS A 216 -35.005 -22.281 -25.704 1.00 40.42 O \\\\nATOM 1721 CG HIS A 216 -37.967 -20.379 -23.206 1.00 40.42 C \\\\nATOM 1722 CD2 HIS A 216 -39.316 -20.482 -22.997 1.00 40.42 C \\\\nATOM 1723 ND1 HIS A 216 -37.497 -19.419 -22.338 1.00 40.42 N \\\\nATOM 1724 CE1 HIS A 216 -38.538 -18.952 -21.629 1.00 40.42 C \\\\nATOM 1725 NE2 HIS A 216 -39.670 -19.572 -21.994 1.00 40.42 N \\\\nATOM 1726 N ASN A 217 -34.301 -20.230 -26.305 1.00 45.94 N \\\\nATOM 1727 CA ASN A 217 -32.886 -20.566 -26.348 1.00 45.94 C \\\\nATOM 1728 C ASN A 217 -32.417 -20.746 -24.900 1.00 45.94 C \\\\nATOM 1729 CB ASN A 217 -32.085 -19.479 -27.098 1.00 45.94 C \\\\nATOM 1730 O ASN A 217 -32.070 -19.777 -24.224 1.00 45.94 O \\\\nATOM 1731 CG ASN A 217 -32.078 -19.656 -28.607 1.00 45.94 C \\\\nATOM 1732 ND2 ASN A 217 -31.390 -18.796 -29.321 1.00 45.94 N \\\\nATOM 1733 OD1 ASN A 217 -32.661 -20.566 -29.167 1.00 45.94 O \\\\nATOM 1734 N ASN A 218 -32.422 -21.996 -24.430 1.00 48.29 N \\\\nATOM 1735 CA ASN A 218 -31.732 -22.420 -23.215 1.00 48.29 C \\\\nATOM 1736 C ASN A 218 -30.218 -22.322 -23.454 1.00 48.29 C \\\\nATOM 1737 CB ASN A 218 -32.196 -23.836 -22.795 1.00 48.29 C \\\\nATOM 1738 O ASN A 218 -29.524 -23.321 -23.636 1.00 48.29 O \\\\nATOM 1739 CG ASN A 218 -33.261 -23.865 -21.712 1.00 48.29 C \\\\nATOM 1740 ND2 ASN A 218 -33.691 -25.044 -21.328 1.00 48.29 N \\\\nATOM 1741 OD1 ASN A 218 -33.708 -22.868 -21.174 1.00 48.29 O \\\\nATOM 1742 N LEU A 219 -29.712 -21.090 -23.470 1.00 60.32 N \\\\nATOM 1743 CA LEU A 219 -28.303 -20.815 -23.246 1.00 60.32 C \\\\nATOM 1744 C LEU A 219 -27.998 -21.275 -21.819 1.00 60.32 C \\\\nATOM 1745 CB LEU A 219 -28.035 -19.313 -23.455 1.00 60.32 C \\\\nATOM 1746 O LEU A 219 -28.474 -20.677 -20.854 1.00 60.32 O \\\\nATOM 1747 CG LEU A 219 -28.042 -18.894 -24.937 1.00 60.32 C \\\\nATOM 1748 CD1 LEU A 219 -28.221 -17.382 -25.062 1.00 60.32 C \\\\nATOM 1749 CD2 LEU A 219 -26.732 -19.278 -25.630 1.00 60.32 C \\\\nATOM 1750 N ASP A 220 -27.247 -22.368 -21.699 1.00 74.45 N \\\\nATOM 1751 CA ASP A 220 -26.793 -22.909 -20.419 1.00 74.45 C \\\\nATOM 1752 C ASP A 220 -25.707 -21.976 -19.855 1.00 74.45 C \\\\nATOM 1753 CB ASP A 220 -26.366 -24.375 -20.612 1.00 74.45 C \\\\nATOM 1754 O ASP A 220 -24.509 -22.128 -20.106 1.00 74.45 O \\\\nATOM 1755 CG ASP A 220 -26.139 -25.137 -19.300 1.00 74.45 C \\\\nATOM 1756 OD1 ASP A 220 -26.610 -24.684 -18.235 1.00 74.45 O \\\\nATOM 1757 OD2 ASP A 220 -25.480 -26.202 -19.357 1.00 74.45 O \\\\nATOM 1758 N LEU A 221 -26.177 -20.912 -19.198 1.00 81.69 N \\\\nATOM 1759 CA LEU A 221 -25.384 -19.817 -18.652 1.00 81.69 C \\\\nATOM 1760 C LEU A 221 -24.868 -20.190 -17.261 1.00 81.69 C \\\\nATOM 1761 CB LEU A 221 -26.244 -18.539 -18.591 1.00 81.69 C \\\\nATOM 1762 O LEU A 221 -25.641 -20.307 -16.308 1.00 81.69 O \\\\nATOM 1763 CG LEU A 221 -26.532 -17.876 -19.951 1.00 81.69 C \\\\nATOM 1764 CD1 LEU A 221 -27.616 -16.809 -19.796 1.00 81.69 C \\\\nATOM 1765 CD2 LEU A 221 -25.300 -17.189 -20.537 1.00 81.69 C \\\\nATOM 1766 N GLN A 222 -23.551 -20.314 -17.121 1.00 85.05 N \\\\nATOM 1767 CA GLN A 222 -22.922 -20.623 -15.844 1.00 85.05 C \\\\nATOM 1768 C GLN A 222 -22.578 -19.327 -15.078 1.00 85.05 C \\\\nATOM 1769 CB GLN A 222 -21.723 -21.549 -16.088 1.00 85.05 C \\\\nATOM 1770 O GLN A 222 -21.875 -18.469 -15.616 1.00 85.05 O \\\\nATOM 1771 CG GLN A 222 -21.146 -22.068 -14.764 1.00 85.05 C \\\\nATOM 1772 CD GLN A 222 -20.201 -23.256 -14.935 1.00 85.05 C \\\\nATOM 1773 NE2 GLN A 222 -19.224 -23.405 -14.071 1.00 85.05 N \\\\nATOM 1774 OE1 GLN A 222 -20.361 -24.133 -15.776 1.00 85.05 O \\\\nATOM 1775 N PRO A 223 -23.056 -19.142 -13.830 1.00 90.37 N \\\\nATOM 1776 CA PRO A 223 -22.756 -17.950 -13.042 1.00 90.37 C \\\\nATOM 1777 C PRO A 223 -21.366 -18.020 -12.394 1.00 90.37 C \\\\nATOM 1778 CB PRO A 223 -23.877 -17.858 -12.003 1.00 90.37 C \\\\nATOM 1779 O PRO A 223 -21.036 -18.970 -11.681 1.00 90.37 O \\\\nATOM 1780 CG PRO A 223 -24.265 -19.319 -11.776 1.00 90.37 C \\\\nATOM 1781 CD PRO A 223 -24.053 -19.958 -13.149 1.00 90.37 C \\\\nATOM 1782 N VAL A 224 -20.577 -16.961 -12.571 1.00 90.45 N \\\\nATOM 1783 CA VAL A 224 -19.236 -16.791 -12.000 1.00 90.45 C \\\\nATOM 1784 C VAL A 224 -19.241 -15.674 -10.963 1.00 90.45 C \\\\nATOM 1785 CB VAL A 224 -18.185 -16.520 -13.094 1.00 90.45 C \\\\nATOM 1786 O VAL A 224 -19.332 -14.489 -11.293 1.00 90.45 O \\\\nATOM 1787 CG1 VAL A 224 -16.787 -16.560 -12.468 1.00 90.45 C \\\\nATOM 1788 CG2 VAL A 224 -18.242 -17.587 -14.185 1.00 90.45 C \\\\nATOM 1789 N THR A 225 -19.119 -16.047 -9.690 1.00 90.96 N \\\\nATOM 1790 CA THR A 225 -19.107 -15.113 -8.558 1.00 90.96 C \\\\nATOM 1791 C THR A 225 -17.708 -14.574 -8.245 1.00 90.96 C \\\\nATOM 1792 CB THR A 225 -19.718 -15.750 -7.299 1.00 90.96 C \\\\nATOM 1793 O THR A 225 -16.707 -15.306 -8.235 1.00 90.96 O \\\\nATOM 1794 CG2 THR A 225 -21.223 -15.974 -7.443 1.00 90.96 C \\\\nATOM 1795 OG1 THR A 225 -19.143 -17.012 -7.043 1.00 90.96 O \\\\nATOM 1796 N TYR A 226 -17.656 -13.279 -7.920 1.00 91.36 N \\\\nATOM 1797 CA TYR A 226 -16.485 -12.645 -7.317 1.00 91.36 C \\\\nATOM 1798 C TYR A 226 -16.177 -13.268 -5.947 1.00 91.36 C \\\\nATOM 1799 CB TYR A 226 -16.729 -11.137 -7.179 1.00 91.36 C \\\\nATOM 1800 O TYR A 226 -17.081 -13.659 -5.205 1.00 91.36 O \\\\nATOM 1801 CG TYR A 226 -15.526 -10.357 -6.675 1.00 91.36 C \\\\nATOM 1802 CD1 TYR A 226 -15.400 -10.011 -5.314 1.00 91.36 C \\\\nATOM 1803 CD2 TYR A 226 -14.536 -9.953 -7.586 1.00 91.36 C \\\\nATOM 1804 CE1 TYR A 226 -14.290 -9.258 -4.874 1.00 91.36 C \\\\nATOM 1805 CE2 TYR A 226 -13.447 -9.174 -7.158 1.00 91.36 C \\\\nATOM 1806 OH TYR A 226 -12.242 -8.086 -5.408 1.00 91.36 O \\\\nATOM 1807 CZ TYR A 226 -13.310 -8.831 -5.798 1.00 91.36 C \\\\nATOM 1808 N CYS A 227 -14.896 -13.343 -5.592 1.00 88.04 N \\\\nATOM 1809 CA CYS A 227 -14.446 -13.685 -4.245 1.00 88.04 C \\\\nATOM 1810 C CYS A 227 -13.320 -12.729 -3.857 1.00 88.04 C \\\\nATOM 1811 CB CYS A 227 -13.971 -15.144 -4.176 1.00 88.04 C \\\\nATOM 1812 O CYS A 227 -12.443 -12.461 -4.673 1.00 88.04 O \\\\nATOM 1813 SG CYS A 227 -15.324 -16.288 -4.590 1.00 88.04 S \\\\nATOM 1814 N GLU A 228 -13.341 -12.228 -2.624 1.00 87.08 N \\\\nATOM 1815 CA GLU A 228 -12.293 -11.333 -2.136 1.00 87.08 C \\\\nATOM 1816 C GLU A 228 -11.044 -12.157 -1.749 1.00 87.08 C \\\\nATOM 1817 CB GLU A 228 -12.835 -10.504 -0.959 1.00 87.08 C \\\\nATOM 1818 O GLU A 228 -11.162 -13.089 -0.945 1.00 87.08 O \\\\nATOM 1819 CG GLU A 228 -12.081 -9.184 -0.760 1.00 87.08 C \\\\nATOM 1820 CD GLU A 228 -12.445 -8.166 -1.847 1.00 87.08 C \\\\nATOM 1821 OE1 GLU A 228 -11.724 -8.084 -2.862 1.00 87.08 O \\\\nATOM 1822 OE2 GLU A 228 -13.462 -7.454 -1.705 1.00 87.08 O \\\\nATOM 1823 N PRO A 229 -9.856 -11.871 -2.307 1.00 91.38 N \\\\nATOM 1824 CA PRO A 229 -8.630 -12.602 -1.993 1.00 91.38 C \\\\nATOM 1825 C PRO A 229 -8.013 -12.151 -0.659 1.00 91.38 C \\\\nATOM 1826 CB PRO A 229 -7.696 -12.322 -3.172 1.00 91.38 C \\\\nATOM 1827 O PRO A 229 -8.198 -11.022 -0.213 1.00 91.38 O \\\\nATOM 1828 CG PRO A 229 -8.092 -10.899 -3.553 1.00 91.38 C \\\\nATOM 1829 CD PRO A 229 -9.602 -10.891 -3.353 1.00 91.38 C \\\\nATOM 1830 N ALA A 230 -7.183 -13.009 -0.054 1.00 90.34 N \\\\nATOM 1831 CA ALA A 230 -6.465 -12.698 1.192 1.00 90.34 C \\\\nATOM 1832 C ALA A 230 -5.456 -11.533 1.066 1.00 90.34 C \\\\nATOM 1833 CB ALA A 230 -5.759 -13.977 1.660 1.00 90.34 C \\\\nATOM 1834 O ALA A 230 -5.130 -10.879 2.056 1.00 90.34 O \\\\nATOM 1835 N PHE A 231 -4.973 -11.272 -0.152 1.00 94.61 N \\\\nATOM 1836 CA PHE A 231 -4.199 -10.086 -0.509 1.00 94.61 C \\\\nATOM 1837 C PHE A 231 -4.930 -9.383 -1.649 1.00 94.61 C \\\\nATOM 1838 CB PHE A 231 -2.775 -10.474 -0.935 1.00 94.61 C \\\\nATOM 1839 O PHE A 231 -5.084 -9.979 -2.715 1.00 94.61 O \\\\nATOM 1840 CG PHE A 231 -1.985 -11.239 0.107 1.00 94.61 C \\\\nATOM 1841 CD1 PHE A 231 -1.300 -10.545 1.119 1.00 94.61 C \\\\nATOM 1842 CD2 PHE A 231 -1.917 -12.644 0.056 1.00 94.61 C \\\\nATOM 1843 CE1 PHE A 231 -0.547 -11.247 2.076 1.00 94.61 C \\\\nATOM 1844 CE2 PHE A 231 -1.170 -13.349 1.017 1.00 94.61 C \\\\nATOM 1845 CZ PHE A 231 -0.486 -12.650 2.027 1.00 94.61 C \\\\nATOM 1846 N TRP A 232 -5.376 -8.142 -1.456 1.00 95.43 N \\\\nATOM 1847 CA TRP A 232 -6.197 -7.431 -2.445 1.00 95.43 C \\\\nATOM 1848 C TRP A 232 -5.375 -6.933 -3.644 1.00 95.43 C \\\\nATOM 1849 CB TRP A 232 -6.971 -6.306 -1.752 1.00 95.43 C \\\\nATOM 1850 O TRP A 232 -5.883 -6.886 -4.766 1.00 95.43 O \\\\nATOM 1851 CG TRP A 232 -6.131 -5.200 -1.196 1.00 95.43 C \\\\nATOM 1852 CD1 TRP A 232 -5.652 -5.120 0.065 1.00 95.43 C \\\\nATOM 1853 CD2 TRP A 232 -5.664 -3.998 -1.878 1.00 95.43 C \\\\nATOM 1854 CE2 TRP A 232 -4.882 -3.233 -0.963 1.00 95.43 C \\\\nATOM 1855 CE3 TRP A 232 -5.831 -3.479 -3.180 1.00 95.43 C \\\\nATOM 1856 NE1 TRP A 232 -4.917 -3.961 0.205 1.00 95.43 N \\\\nATOM 1857 CH2 TRP A 232 -4.469 -1.529 -2.630 1.00 95.43 C \\\\nATOM 1858 CZ2 TRP A 232 -4.287 -2.015 -1.323 1.00 95.43 C \\\\nATOM 1859 CZ3 TRP A 232 -5.238 -2.259 -3.554 1.00 95.43 C \\\\nATOM 1860 N CYS A 233 -4.085 -6.643 -3.443 1.00 97.66 N \\\\nATOM 1861 CA CYS A 233 -3.142 -6.409 -4.533 1.00 97.66 C \\\\nATOM 1862 C CYS A 233 -1.744 -6.980 -4.268 1.00 97.66 C \\\\nATOM 1863 CB CYS A 233 -3.097 -4.915 -4.904 1.00 97.66 C \\\\nATOM 1864 O CYS A 233 -1.371 -7.311 -3.137 1.00 97.66 O \\\\nATOM 1865 SG CYS A 233 -2.220 -3.908 -3.672 1.00 97.66 S \\\\nATOM 1866 N SER A 234 -0.963 -7.073 -5.340 1.00 98.00 N \\\\nATOM 1867 CA SER A 234 0.484 -7.274 -5.297 1.00 98.00 C \\\\nATOM 1868 C SER A 234 1.196 -6.126 -6.021 1.00 98.00 C \\\\nATOM 1869 CB SER A 234 0.855 -8.653 -5.846 1.00 98.00 C \\\\nATOM 1870 O SER A 234 0.656 -5.569 -6.978 1.00 98.00 O \\\\nATOM 1871 OG SER A 234 0.561 -8.773 -7.220 1.00 98.00 O \\\\nATOM 1872 N ILE A 235 2.374 -5.727 -5.534 1.00 98.48 N \\\\nATOM 1873 CA ILE A 235 3.124 -4.561 -6.018 1.00 98.48 C \\\\nATOM 1874 C ILE A 235 4.563 -4.957 -6.337 1.00 98.48 C \\\\nATOM 1875 CB ILE A 235 3.083 -3.380 -5.017 1.00 98.48 C \\\\nATOM 1876 O ILE A 235 5.286 -5.443 -5.467 1.00 98.48 O \\\\nATOM 1877 CG1 ILE A 235 1.628 -3.071 -4.597 1.00 98.48 C \\\\nATOM 1878 CG2 ILE A 235 3.764 -2.146 -5.646 1.00 98.48 C \\\\nATOM 1879 CD1 ILE A 235 1.453 -1.811 -3.745 1.00 98.48 C \\\\nATOM 1880 N SER A 236 5.002 -4.695 -7.566 1.00 98.56 N \\\\nATOM 1881 CA SER A 236 6.394 -4.879 -7.998 1.00 98.56 C \\\\nATOM 1882 C SER A 236 7.045 -3.523 -8.282 1.00 98.56 C \\\\nATOM 1883 CB SER A 236 6.453 -5.806 -9.215 1.00 98.56 C \\\\nATOM 1884 O SER A 236 6.434 -2.671 -8.924 1.00 98.56 O \\\\nATOM 1885 OG SER A 236 5.926 -7.081 -8.879 1.00 98.56 O \\\\nATOM 1886 N TYR A 237 8.271 -3.307 -7.796 1.00 98.69 N \\\\nATOM 1887 CA TYR A 237 9.032 -2.067 -7.999 1.00 98.69 C \\\\nATOM 1888 C TYR A 237 10.047 -2.195 -9.137 1.00 98.69 C \\\\nATOM 1889 CB TYR A 237 9.692 -1.633 -6.680 1.00 98.69 C \\\\nATOM 1890 O TYR A 237 10.666 -3.245 -9.328 1.00 98.69 O \\\\nATOM 1891 CG TYR A 237 10.637 -0.444 -6.789 1.00 98.69 C \\\\nATOM 1892 CD1 TYR A 237 12.003 -0.597 -6.486 1.00 98.69 C \\\\nATOM 1893 CD2 TYR A 237 10.156 0.816 -7.191 1.00 98.69 C \\\\nATOM 1894 CE1 TYR A 237 12.878 0.503 -6.562 1.00 98.69 C \\\\nATOM 1895 CE2 TYR A 237 11.029 1.915 -7.294 1.00 98.69 C \\\\nATOM 1896 OH TYR A 237 13.219 2.844 -6.988 1.00 98.69 O \\\\nATOM 1897 CZ TYR A 237 12.391 1.765 -6.962 1.00 98.69 C \\\\nATOM 1898 N TYR A 238 10.217 -1.103 -9.881 1.00 98.77 N \\\\nATOM 1899 CA TYR A 238 11.071 -1.011 -11.053 1.00 98.77 C \\\\nATOM 1900 C TYR A 238 11.893 0.282 -11.053 1.00 98.77 C \\\\nATOM 1901 CB TYR A 238 10.215 -1.095 -12.322 1.00 98.77 C \\\\nATOM 1902 O TYR A 238 11.424 1.369 -10.693 1.00 98.77 O \\\\nATOM 1903 CG TYR A 238 9.557 -2.438 -12.582 1.00 98.77 C \\\\nATOM 1904 CD1 TYR A 238 10.127 -3.335 -13.507 1.00 98.77 C \\\\nATOM 1905 CD2 TYR A 238 8.351 -2.771 -11.935 1.00 98.77 C \\\\nATOM 1906 CE1 TYR A 238 9.513 -4.577 -13.760 1.00 98.77 C \\\\nATOM 1907 CE2 TYR A 238 7.751 -4.023 -12.163 1.00 98.77 C \\\\nATOM 1908 OH TYR A 238 7.774 -6.155 -13.249 1.00 98.77 O \\\\nATOM 1909 CZ TYR A 238 8.338 -4.934 -13.063 1.00 98.77 C \\\\nATOM 1910 N GLU A 239 13.128 0.159 -11.527 1.00 98.62 N \\\\nATOM 1911 CA GLU A 239 14.019 1.264 -11.862 1.00 98.62 C \\\\nATOM 1912 C GLU A 239 14.323 1.165 -13.362 1.00 98.62 C \\\\nATOM 1913 CB GLU A 239 15.284 1.228 -10.979 1.00 98.62 C \\\\nATOM 1914 O GLU A 239 14.958 0.211 -13.810 1.00 98.62 O \\\\nATOM 1915 CG GLU A 239 14.940 1.495 -9.500 1.00 98.62 C \\\\nATOM 1916 CD GLU A 239 16.132 1.483 -8.527 1.00 98.62 C \\\\nATOM 1917 OE1 GLU A 239 15.922 1.704 -7.311 1.00 98.62 O \\\\nATOM 1918 OE2 GLU A 239 17.306 1.282 -8.916 1.00 98.62 O \\\\nATOM 1919 N LEU A 240 13.834 2.127 -14.153 1.00 98.06 N \\\\nATOM 1920 CA LEU A 240 13.823 2.051 -15.621 1.00 98.06 C \\\\nATOM 1921 C LEU A 240 13.079 0.792 -16.117 1.00 98.06 C \\\\nATOM 1922 CB LEU A 240 15.248 2.233 -16.192 1.00 98.06 C \\\\nATOM 1923 O LEU A 240 11.916 0.600 -15.776 1.00 98.06 O \\\\nATOM 1924 CG LEU A 240 15.969 3.510 -15.728 1.00 98.06 C \\\\nATOM 1925 CD1 LEU A 240 17.434 3.448 -16.154 1.00 98.06 C \\\\nATOM 1926 CD2 LEU A 240 15.350 4.776 -16.327 1.00 98.06 C \\\\nATOM 1927 N ASN A 241 13.710 -0.073 -16.912 1.00 97.14 N \\\\nATOM 1928 CA ASN A 241 13.154 -1.360 -17.346 1.00 97.14 C \\\\nATOM 1929 C ASN A 241 13.502 -2.533 -16.405 1.00 97.14 C \\\\nATOM 1930 CB ASN A 241 13.596 -1.633 -18.797 1.00 97.14 C \\\\nATOM 1931 O ASN A 241 13.069 -3.658 -16.655 1.00 97.14 O \\\\nATOM 1932 CG ASN A 241 15.097 -1.813 -18.965 1.00 97.14 C \\\\nATOM 1933 ND2 ASN A 241 15.528 -2.374 -20.069 1.00 97.14 N \\\\nATOM 1934 OD1 ASN A 241 15.903 -1.420 -18.136 1.00 97.14 O \\\\nATOM 1935 N GLN A 242 14.276 -2.305 -15.340 1.00 97.90 N \\\\nATOM 1936 CA GLN A 242 14.739 -3.357 -14.439 1.00 97.90 C \\\\nATOM 1937 C GLN A 242 13.834 -3.473 -13.211 1.00 97.90 C \\\\nATOM 1938 CB GLN A 242 16.203 -3.092 -14.058 1.00 97.90 C \\\\nATOM 1939 O GLN A 242 13.608 -2.500 -12.494 1.00 97.90 O \\\\nATOM 1940 CG GLN A 242 16.783 -4.233 -13.207 1.00 97.90 C \\\\nATOM 1941 CD GLN A 242 18.248 -4.032 -12.846 1.00 97.90 C \\\\nATOM 1942 NE2 GLN A 242 18.831 -4.925 -12.081 1.00 97.90 N \\\\nATOM 1943 OE1 GLN A 242 18.908 -3.084 -13.238 1.00 97.90 O \\\\nATOM 1944 N ARG A 243 13.365 -4.690 -12.920 1.00 98.06 N \\\\nATOM 1945 CA ARG A 243 12.677 -5.004 -11.663 1.00 98.06 C \\\\nATOM 1946 C ARG A 243 13.668 -4.998 -10.495 1.00 98.06 C \\\\nATOM 1947 CB ARG A 243 11.953 -6.346 -11.809 1.00 98.06 C \\\\nATOM 1948 O ARG A 243 14.748 -5.576 -10.598 1.00 98.06 O \\\\nATOM 1949 CG ARG A 243 11.106 -6.643 -10.571 1.00 98.06 C \\\\nATOM 1950 CD ARG A 243 10.301 -7.925 -10.764 1.00 98.06 C \\\\nATOM 1951 NE ARG A 243 9.956 -8.477 -9.451 1.00 98.06 N \\\\nATOM 1952 NH1 ARG A 243 8.193 -9.836 -10.058 1.00 98.06 N \\\\nATOM 1953 NH2 ARG A 243 8.897 -9.730 -7.940 1.00 98.06 N \\\\nATOM 1954 CZ ARG A 243 9.014 -9.349 -9.171 1.00 98.06 C \\\\nATOM 1955 N VAL A 244 13.291 -4.378 -9.379 1.00 98.38 N \\\\nATOM 1956 CA VAL A 244 14.143 -4.200 -8.196 1.00 98.38 C \\\\nATOM 1957 C VAL A 244 13.391 -4.645 -6.941 1.00 98.38 C \\\\nATOM 1958 CB VAL A 244 14.626 -2.736 -8.101 1.00 98.38 C \\\\nATOM 1959 O VAL A 244 12.381 -4.055 -6.570 1.00 98.38 O \\\\nATOM 1960 CG1 VAL A 244 15.439 -2.476 -6.827 1.00 98.38 C \\\\nATOM 1961 CG2 VAL A 244 15.519 -2.366 -9.293 1.00 98.38 C \\\\nATOM 1962 N GLY A 245 13.918 -5.665 -6.260 1.00 96.94 N \\\\nATOM 1963 CA GLY A 245 13.327 -6.223 -5.041 1.00 96.94 C \\\\nATOM 1964 C GLY A 245 12.210 -7.251 -5.269 1.00 96.94 C \\\\nATOM 1965 O GLY A 245 11.853 -7.617 -6.394 1.00 96.94 O \\\\nATOM 1966 N GLU A 246 11.680 -7.746 -4.153 1.00 96.05 N \\\\nATOM 1967 CA GLU A 246 10.594 -8.728 -4.106 1.00 96.05 C \\\\nATOM 1968 C GLU A 246 9.227 -8.084 -4.399 1.00 96.05 C \\\\nATOM 1969 CB GLU A 246 10.600 -9.438 -2.742 1.00 96.05 C \\\\nATOM 1970 O GLU A 246 9.067 -6.864 -4.327 1.00 96.05 O \\\\nATOM 1971 CG GLU A 246 11.927 -10.178 -2.493 1.00 96.05 C \\\\nATOM 1972 CD GLU A 246 11.932 -10.976 -1.182 1.00 96.05 C \\\\nATOM 1973 OE1 GLU A 246 12.596 -12.035 -1.169 1.00 96.05 O \\\\nATOM 1974 OE2 GLU A 246 11.300 -10.506 -0.211 1.00 96.05 O \\\\nATOM 1975 N THR A 247 8.223 -8.900 -4.741 1.00 97.28 N \\\\nATOM 1976 CA THR A 247 6.836 -8.416 -4.842 1.00 97.28 C \\\\nATOM 1977 C THR A 247 6.261 -8.242 -3.439 1.00 97.28 C \\\\nATOM 1978 CB THR A 247 5.942 -9.364 -5.659 1.00 97.28 C \\\\nATOM 1979 O THR A 247 6.203 -9.197 -2.663 1.00 97.28 O \\\\nATOM 1980 CG2 THR A 247 4.483 -8.934 -5.724 1.00 97.28 C \\\\nATOM 1981 OG1 THR A 247 6.361 -9.404 -7.003 1.00 97.28 O \\\\nATOM 1982 N PHE A 248 5.779 -7.043 -3.130 1.00 97.00 N \\\\nATOM 1983 CA PHE A 248 5.022 -6.783 -1.912 1.00 97.00 C \\\\nATOM 1984 C PHE A 248 3.574 -7.265 -2.077 1.00 97.00 C \\\\nATOM 1985 CB PHE A 248 5.102 -5.290 -1.588 1.00 97.00 C \\\\nATOM 1986 O PHE A 248 2.968 -7.046 -3.124 1.00 97.00 O \\\\nATOM 1987 CG PHE A 248 4.498 -4.937 -0.248 1.00 97.00 C \\\\nATOM 1988 CD1 PHE A 248 3.108 -4.751 -0.124 1.00 97.00 C \\\\nATOM 1989 CD2 PHE A 248 5.327 -4.822 0.884 1.00 97.00 C \\\\nATOM 1990 CE1 PHE A 248 2.550 -4.462 1.132 1.00 97.00 C \\\\nATOM 1991 CE2 PHE A 248 4.771 -4.501 2.134 1.00 97.00 C \\\\nATOM 1992 CZ PHE A 248 3.383 -4.322 2.254 1.00 97.00 C \\\\nATOM 1993 N HIS A 249 2.996 -7.886 -1.048 1.00 97.02 N \\\\nATOM 1994 CA HIS A 249 1.628 -8.415 -1.075 1.00 97.02 C \\\\nATOM 1995 C HIS A 249 0.777 -7.718 -0.006 1.00 97.02 C \\\\nATOM 1996 CB HIS A 249 1.668 -9.938 -0.893 1.00 97.02 C \\\\nATOM 1997 O HIS A 249 1.065 -7.816 1.186 1.00 97.02 O \\\\nATOM 1998 CG HIS A 249 2.379 -10.664 -2.010 1.00 97.02 C \\\\nATOM 1999 CD2 HIS A 249 1.784 -11.303 -3.065 1.00 97.02 C \\\\nATOM 2000 ND1 HIS A 249 3.740 -10.819 -2.165 1.00 97.02 N \\\\nATOM 2001 CE1 HIS A 249 3.954 -11.537 -3.277 1.00 97.02 C \\\\nATOM 2002 NE2 HIS A 249 2.791 -11.844 -3.870 1.00 97.02 N \\\\nATOM 2003 N ALA A 250 -0.265 -6.997 -0.425 1.00 95.01 N \\\\nATOM 2004 CA ALA A 250 -1.051 -6.142 0.459 1.00 95.01 C \\\\nATOM 2005 C ALA A 250 -2.266 -6.885 1.031 1.00 95.01 C \\\\nATOM 2006 CB ALA A 250 -1.460 -4.890 -0.323 1.00 95.01 C \\\\nATOM 2007 O ALA A 250 -3.233 -7.147 0.317 1.00 95.01 O \\\\nATOM 2008 N SER A 251 -2.227 -7.219 2.324 1.00 91.07 N \\\\nATOM 2009 CA SER A 251 -3.373 -7.794 3.047 1.00 91.07 C \\\\nATOM 2010 C SER A 251 -4.229 -6.731 3.737 1.00 91.07 C \\\\nATOM 2011 CB SER A 251 -2.896 -8.827 4.069 1.00 91.07 C \\\\nATOM 2012 O SER A 251 -5.447 -6.868 3.805 1.00 91.07 O \\\\nATOM 2013 OG SER A 251 -1.964 -8.254 4.975 1.00 91.07 O \\\\nATOM 2014 N GLN A 252 -3.615 -5.649 4.226 1.00 90.73 N \\\\nATOM 2015 CA GLN A 252 -4.331 -4.580 4.924 1.00 90.73 C \\\\nATOM 2016 C GLN A 252 -5.089 -3.667 3.945 1.00 90.73 C \\\\nATOM 2017 CB GLN A 252 -3.369 -3.767 5.810 1.00 90.73 C \\\\nATOM 2018 O GLN A 252 -4.523 -3.317 2.904 1.00 90.73 O \\\\nATOM 2019 CG GLN A 252 -2.758 -4.604 6.947 1.00 90.73 C \\\\nATOM 2020 CD GLN A 252 -3.801 -5.213 7.884 1.00 90.73 C \\\\nATOM 2021 NE2 GLN A 252 -3.472 -6.274 8.586 1.00 90.73 N \\\\nATOM 2022 OE1 GLN A 252 -4.936 -4.780 7.987 1.00 90.73 O \\\\nATOM 2023 N PRO A 253 -6.313 -3.194 4.272 1.00 90.20 N \\\\nATOM 2024 CA PRO A 253 -7.105 -2.315 3.397 1.00 90.20 C \\\\nATOM 2025 C PRO A 253 -6.448 -0.966 3.070 1.00 90.20 C \\\\nATOM 2026 CB PRO A 253 -8.428 -2.075 4.136 1.00 90.20 C \\\\nATOM 2027 O PRO A 253 -6.895 -0.256 2.175 1.00 90.20 O \\\\nATOM 2028 CG PRO A 253 -8.556 -3.278 5.064 1.00 90.20 C \\\\nATOM 2029 CD PRO A 253 -7.107 -3.576 5.437 1.00 90.20 C \\\\nATOM 2030 N SER A 254 -5.403 -0.580 3.802 1.00 93.37 N \\\\nATOM 2031 CA SER A 254 -4.603 0.618 3.560 1.00 93.37 C \\\\nATOM 2032 C SER A 254 -3.127 0.267 3.695 1.00 93.37 C \\\\nATOM 2033 CB SER A 254 -5.004 1.713 4.557 1.00 93.37 C \\\\nATOM 2034 O SER A 254 -2.726 -0.324 4.692 1.00 93.37 O \\\\nATOM 2035 OG SER A 254 -4.131 2.832 4.511 1.00 93.37 O \\\\nATOM 2036 N MET A 255 -2.311 0.706 2.741 1.00 95.32 N \\\\nATOM 2037 CA MET A 255 -0.854 0.588 2.792 1.00 95.32 C \\\\nATOM 2038 C MET A 255 -0.169 1.840 2.233 1.00 95.32 C \\\\nATOM 2039 CB MET A 255 -0.395 -0.682 2.060 1.00 95.32 C \\\\nATOM 2040 O MET A 255 -0.796 2.671 1.576 1.00 95.32 O \\\\nATOM 2041 CG MET A 255 -0.550 -0.591 0.534 1.00 95.32 C \\\\nATOM 2042 SD MET A 255 0.361 -1.848 -0.389 1.00 95.32 S \\\\nATOM 2043 CE MET A 255 2.074 -1.433 0.046 1.00 95.32 C \\\\nATOM 2044 N THR A 256 1.135 1.974 2.461 1.00 97.98 N \\\\nATOM 2045 CA THR A 256 1.963 3.043 1.885 1.00 97.98 C \\\\nATOM 2046 C THR A 256 3.144 2.443 1.129 1.00 97.98 C \\\\nATOM 2047 CB THR A 256 2.449 4.016 2.971 1.00 97.98 C \\\\nATOM 2048 O THR A 256 3.807 1.546 1.639 1.00 97.98 O \\\\nATOM 2049 CG2 THR A 256 3.014 5.307 2.385 1.00 97.98 C \\\\nATOM 2050 OG1 THR A 256 1.371 4.392 3.804 1.00 97.98 O \\\\nATOM 2051 N VAL A 257 3.434 2.942 -0.070 1.00 98.59 N \\\\nATOM 2052 CA VAL A 257 4.696 2.681 -0.775 1.00 98.59 C \\\\nATOM 2053 C VAL A 257 5.546 3.939 -0.637 1.00 98.59 C \\\\nATOM 2054 CB VAL A 257 4.466 2.311 -2.252 1.00 98.59 C \\\\nATOM 2055 O VAL A 257 5.147 4.992 -1.136 1.00 98.59 O \\\\nATOM 2056 CG1 VAL A 257 5.791 1.898 -2.897 1.00 98.59 C \\\\nATOM 2057 CG2 VAL A 257 3.451 1.175 -2.436 1.00 98.59 C \\\\nATOM 2058 N ASP A 258 6.672 3.861 0.073 1.00 98.59 N \\\\nATOM 2059 CA ASP A 258 7.464 5.030 0.481 1.00 98.59 C \\\\nATOM 2060 C ASP A 258 8.975 4.871 0.236 1.00 98.59 C \\\\nATOM 2061 CB ASP A 258 7.095 5.455 1.918 1.00 98.59 C \\\\nATOM 2062 O ASP A 258 9.464 3.803 -0.117 1.00 98.59 O \\\\nATOM 2063 CG ASP A 258 7.618 4.573 3.055 1.00 98.59 C \\\\nATOM 2064 OD1 ASP A 258 8.842 4.336 3.109 1.00 98.59 O \\\\nATOM 2065 OD2 ASP A 258 6.856 4.304 4.015 1.00 98.59 O \\\\nATOM 2066 N GLY A 259 9.722 5.970 0.356 1.00 98.35 N \\\\nATOM 2067 CA GLY A 259 11.163 6.037 0.098 1.00 98.35 C \\\\nATOM 2068 C GLY A 259 12.046 5.753 1.317 1.00 98.35 C \\\\nATOM 2069 O GLY A 259 13.248 6.001 1.246 1.00 98.35 O \\\\nATOM 2070 N PHE A 260 11.484 5.287 2.436 1.00 97.98 N \\\\nATOM 2071 CA PHE A 260 12.225 5.007 3.667 1.00 97.98 C \\\\nATOM 2072 C PHE A 260 12.692 3.537 3.722 1.00 97.98 C \\\\nATOM 2073 CB PHE A 260 11.377 5.441 4.874 1.00 97.98 C \\\\nATOM 2074 O PHE A 260 12.752 2.855 2.700 1.00 97.98 O \\\\nATOM 2075 CG PHE A 260 10.859 6.873 4.828 1.00 97.98 C \\\\nATOM 2076 CD1 PHE A 260 11.765 7.951 4.833 1.00 97.98 C \\\\nATOM 2077 CD2 PHE A 260 9.476 7.137 4.793 1.00 97.98 C \\\\nATOM 2078 CE1 PHE A 260 11.293 9.276 4.802 1.00 97.98 C \\\\nATOM 2079 CE2 PHE A 260 9.002 8.460 4.769 1.00 97.98 C \\\\nATOM 2080 CZ PHE A 260 9.911 9.533 4.771 1.00 97.98 C \\\\nATOM 2081 N THR A 261 13.114 3.057 4.898 1.00 97.45 N \\\\nATOM 2082 CA THR A 261 13.944 1.843 5.042 1.00 97.45 C \\\\nATOM 2083 C THR A 261 13.457 0.865 6.124 1.00 97.45 C \\\\nATOM 2084 CB THR A 261 15.413 2.228 5.303 1.00 97.45 C \\\\nATOM 2085 O THR A 261 14.274 0.237 6.791 1.00 97.45 O \\\\nATOM 2086 CG2 THR A 261 16.016 3.142 4.236 1.00 97.45 C \\\\nATOM 2087 OG1 THR A 261 15.497 2.905 6.536 1.00 97.45 O \\\\nATOM 2088 N ASP A 262 12.148 0.768 6.359 1.00 95.17 N \\\\nATOM 2089 CA ASP A 262 11.557 -0.171 7.330 1.00 95.17 C \\\\nATOM 2090 C ASP A 262 11.226 -1.508 6.631 1.00 95.17 C \\\\nATOM 2091 CB ASP A 262 10.329 0.514 7.949 1.00 95.17 C \\\\nATOM 2092 O ASP A 262 10.349 -1.517 5.765 1.00 95.17 O \\\\nATOM 2093 CG ASP A 262 9.506 -0.309 8.941 1.00 95.17 C \\\\nATOM 2094 OD1 ASP A 262 9.875 -1.471 9.213 1.00 95.17 O \\\\nATOM 2095 OD2 ASP A 262 8.501 0.287 9.413 1.00 95.17 O \\\\nATOM 2096 N PRO A 263 11.930 -2.617 6.940 1.00 92.14 N \\\\nATOM 2097 CA PRO A 263 11.783 -3.882 6.221 1.00 92.14 C \\\\nATOM 2098 C PRO A 263 10.658 -4.780 6.757 1.00 92.14 C \\\\nATOM 2099 CB PRO A 263 13.144 -4.569 6.390 1.00 92.14 C \\\\nATOM 2100 O PRO A 263 10.397 -5.820 6.161 1.00 92.14 O \\\\nATOM 2101 CG PRO A 263 13.546 -4.156 7.805 1.00 92.14 C \\\\nATOM 2102 CD PRO A 263 13.025 -2.721 7.898 1.00 92.14 C \\\\nATOM 2103 N SER A 264 10.043 -4.456 7.901 1.00 89.29 N \\\\nATOM 2104 CA SER A 264 9.228 -5.412 8.675 1.00 89.29 C \\\\nATOM 2105 C SER A 264 7.748 -5.047 8.797 1.00 89.29 C \\\\nATOM 2106 CB SER A 264 9.852 -5.611 10.058 1.00 89.29 C \\\\nATOM 2107 O SER A 264 6.975 -5.786 9.409 1.00 89.29 O \\\\nATOM 2108 OG SER A 264 9.904 -4.393 10.775 1.00 89.29 O \\\\nATOM 2109 N ASN A 265 7.334 -3.917 8.228 1.00 88.56 N \\\\nATOM 2110 CA ASN A 265 5.992 -3.379 8.391 1.00 88.56 C \\\\nATOM 2111 C ASN A 265 5.062 -3.788 7.234 1.00 88.56 C \\\\nATOM 2112 CB ASN A 265 6.154 -1.869 8.581 1.00 88.56 C \\\\nATOM 2113 O ASN A 265 5.209 -3.325 6.106 1.00 88.56 O \\\\nATOM 2114 CG ASN A 265 4.866 -1.162 8.931 1.00 88.56 C \\\\nATOM 2115 ND2 ASN A 265 4.961 -0.102 9.695 1.00 88.56 N \\\\nATOM 2116 OD1 ASN A 265 3.773 -1.539 8.554 1.00 88.56 O \\\\nATOM 2117 N SER A 266 4.054 -4.613 7.527 1.00 89.15 N \\\\nATOM 2118 CA SER A 266 3.077 -5.123 6.550 1.00 89.15 C \\\\nATOM 2119 C SER A 266 2.102 -4.074 5.990 1.00 89.15 C \\\\nATOM 2120 CB SER A 266 2.299 -6.287 7.168 1.00 89.15 C \\\\nATOM 2121 O SER A 266 1.358 -4.377 5.060 1.00 89.15 O \\\\nATOM 2122 OG SER A 266 1.744 -5.908 8.415 1.00 89.15 O \\\\nATOM 2123 N GLU A 267 2.116 -2.839 6.498 1.00 92.42 N \\\\nATOM 2124 CA GLU A 267 1.410 -1.688 5.916 1.00 92.42 C \\\\nATOM 2125 C GLU A 267 2.337 -0.796 5.064 1.00 92.42 C \\\\nATOM 2126 CB GLU A 267 0.740 -0.852 7.025 1.00 92.42 C \\\\nATOM 2127 O GLU A 267 1.879 0.211 4.517 1.00 92.42 O \\\\nATOM 2128 CG GLU A 267 -0.372 -1.588 7.791 1.00 92.42 C \\\\nATOM 2129 CD GLU A 267 -0.968 -0.749 8.942 1.00 92.42 C \\\\nATOM 2130 OE1 GLU A 267 -1.641 -1.347 9.812 1.00 92.42 O \\\\nATOM 2131 OE2 GLU A 267 -0.756 0.490 8.978 1.00 92.42 O \\\\nATOM 2132 N ARG A 268 3.642 -1.106 4.951 1.00 96.71 N \\\\nATOM 2133 CA ARG A 268 4.633 -0.235 4.295 1.00 96.71 C \\\\nATOM 2134 C ARG A 268 5.581 -0.984 3.360 1.00 96.71 C \\\\nATOM 2135 CB ARG A 268 5.451 0.535 5.336 1.00 96.71 C \\\\nATOM 2136 O ARG A 268 6.459 -1.720 3.799 1.00 96.71 O \\\\nATOM 2137 CG ARG A 268 4.598 1.470 6.205 1.00 96.71 C \\\\nATOM 2138 CD ARG A 268 5.471 2.197 7.229 1.00 96.71 C \\\\nATOM 2139 NE ARG A 268 6.461 3.067 6.578 1.00 96.71 N \\\\nATOM 2140 NH1 ARG A 268 8.178 2.875 8.116 1.00 96.71 N \\\\nATOM 2141 NH2 ARG A 268 8.428 4.071 6.252 1.00 96.71 N \\\\nATOM 2142 CZ ARG A 268 7.677 3.330 7.000 1.00 96.71 C \\\\nATOM 2143 N PHE A 269 5.496 -0.685 2.067 1.00 97.68 N \\\\nATOM 2144 CA PHE A 269 6.505 -1.092 1.095 1.00 97.68 C \\\\nATOM 2145 C PHE A 269 7.594 -0.013 0.995 1.00 97.68 C \\\\nATOM 2146 CB PHE A 269 5.841 -1.419 -0.246 1.00 97.68 C \\\\nATOM 2147 O PHE A 269 7.465 0.977 0.272 1.00 97.68 O \\\\nATOM 2148 CG PHE A 269 6.732 -2.035 -1.317 1.00 97.68 C \\\\nATOM 2149 CD1 PHE A 269 6.290 -2.019 -2.654 1.00 97.68 C \\\\nATOM 2150 CD2 PHE A 269 7.951 -2.678 -1.003 1.00 97.68 C \\\\nATOM 2151 CE1 PHE A 269 7.051 -2.635 -3.663 1.00 97.68 C \\\\nATOM 2152 CE2 PHE A 269 8.709 -3.292 -2.014 1.00 97.68 C \\\\nATOM 2153 CZ PHE A 269 8.260 -3.274 -3.343 1.00 97.68 C \\\\nATOM 2154 N CYS A 270 8.660 -0.192 1.772 1.00 97.96 N \\\\nATOM 2155 CA CYS A 270 9.772 0.749 1.880 1.00 97.96 C \\\\nATOM 2156 C CYS A 270 10.801 0.547 0.756 1.00 97.96 C \\\\nATOM 2157 CB CYS A 270 10.393 0.560 3.264 1.00 97.96 C \\\\nATOM 2158 O CYS A 270 11.706 -0.278 0.855 1.00 97.96 O \\\\nATOM 2159 SG CYS A 270 9.279 1.227 4.523 1.00 97.96 S \\\\nATOM 2160 N LEU A 271 10.700 1.336 -0.313 1.00 98.37 N \\\\nATOM 2161 CA LEU A 271 11.570 1.252 -1.490 1.00 98.37 C \\\\nATOM 2162 C LEU A 271 13.017 1.677 -1.204 1.00 98.37 C \\\\nATOM 2163 CB LEU A 271 10.985 2.129 -2.613 1.00 98.37 C \\\\nATOM 2164 O LEU A 271 13.931 1.282 -1.934 1.00 98.37 O \\\\nATOM 2165 CG LEU A 271 9.530 1.812 -3.013 1.00 98.37 C \\\\nATOM 2166 CD1 LEU A 271 9.126 2.737 -4.161 1.00 98.37 C \\\\nATOM 2167 CD2 LEU A 271 9.361 0.360 -3.452 1.00 98.37 C \\\\nATOM 2168 N GLY A 272 13.246 2.484 -0.163 1.00 97.79 N \\\\nATOM 2169 CA GLY A 272 14.545 3.069 0.179 1.00 97.79 C \\\\nATOM 2170 C GLY A 272 15.617 2.040 0.545 1.00 97.79 C \\\\nATOM 2171 O GLY A 272 16.781 2.254 0.210 1.00 97.79 O \\\\nATOM 2172 N LEU A 273 15.226 0.906 1.141 1.00 96.65 N \\\\nATOM 2173 CA LEU A 273 16.139 -0.196 1.493 1.00 96.65 C \\\\nATOM 2174 C LEU A 273 16.521 -1.096 0.307 1.00 96.65 C \\\\nATOM 2175 CB LEU A 273 15.547 -1.007 2.665 1.00 96.65 C \\\\nATOM 2176 O LEU A 273 17.466 -1.872 0.412 1.00 96.65 O \\\\nATOM 2177 CG LEU A 273 14.300 -1.851 2.311 1.00 96.65 C \\\\nATOM 2178 CD1 LEU A 273 14.642 -3.321 2.064 1.00 96.65 C \\\\nATOM 2179 CD2 LEU A 273 13.283 -1.793 3.449 1.00 96.65 C \\\\nATOM 2180 N LEU A 274 15.799 -1.014 -0.815 1.00 97.53 N \\\\nATOM 2181 CA LEU A 274 16.035 -1.883 -1.966 1.00 97.53 C \\\\nATOM 2182 C LEU A 274 17.331 -1.493 -2.693 1.00 97.53 C \\\\nATOM 2183 CB LEU A 274 14.819 -1.875 -2.911 1.00 97.53 C \\\\nATOM 2184 O LEU A 274 17.503 -0.348 -3.127 1.00 97.53 O \\\\nATOM 2185 CG LEU A 274 13.475 -2.263 -2.261 1.00 97.53 C \\\\nATOM 2186 CD1 LEU A 274 12.360 -2.159 -3.298 1.00 97.53 C \\\\nATOM 2187 CD2 LEU A 274 13.486 -3.689 -1.708 1.00 97.53 C \\\\nATOM 2188 N SER A 275 18.231 -2.457 -2.866 1.00 97.29 N \\\\nATOM 2189 CA SER A 275 19.495 -2.297 -3.593 1.00 97.29 C \\\\nATOM 2190 C SER A 275 19.337 -2.595 -5.084 1.00 97.29 C \\\\nATOM 2191 CB SER A 275 20.570 -3.202 -2.989 1.00 97.29 C \\\\nATOM 2192 O SER A 275 18.613 -3.508 -5.468 1.00 97.29 O \\\\nATOM 2193 OG SER A 275 20.889 -2.729 -1.698 1.00 97.29 O \\\\nATOM 2194 N ASN A 276 20.062 -1.854 -5.922 1.00 97.60 N \\\\nATOM 2195 CA ASN A 276 20.222 -2.133 -7.348 1.00 97.60 C \\\\nATOM 2196 C ASN A 276 21.642 -1.728 -7.766 1.00 97.60 C \\\\nATOM 2197 CB ASN A 276 19.150 -1.372 -8.147 1.00 97.60 C \\\\nATOM 2198 O ASN A 276 22.036 -0.583 -7.550 1.00 97.60 O \\\\nATOM 2199 CG ASN A 276 19.281 -1.562 -9.649 1.00 97.60 C \\\\nATOM 2200 ND2 ASN A 276 18.599 -0.758 -10.423 1.00 97.60 N \\\\nATOM 2201 OD1 ASN A 276 20.009 -2.418 -10.132 1.00 97.60 O \\\\nATOM 2202 N VAL A 277 22.401 -2.660 -8.347 1.00 97.53 N \\\\nATOM 2203 CA VAL A 277 23.790 -2.432 -8.788 1.00 97.53 C \\\\nATOM 2204 C VAL A 277 23.883 -1.607 -10.075 1.00 97.53 C \\\\nATOM 2205 CB VAL A 277 24.560 -3.758 -8.942 1.00 97.53 C \\\\nATOM 2206 O VAL A 277 24.888 -0.944 -10.296 1.00 97.53 O \\\\nATOM 2207 CG1 VAL A 277 24.703 -4.463 -7.586 1.00 97.53 C \\\\nATOM 2208 CG2 VAL A 277 23.902 -4.734 -9.928 1.00 97.53 C \\\\nATOM 2209 N ASN A 278 22.820 -1.582 -10.886 1.00 97.11 N \\\\nATOM 2210 CA ASN A 278 22.754 -0.822 -12.142 1.00 97.11 C \\\\nATOM 2211 C ASN A 278 22.172 0.592 -11.951 1.00 97.11 C \\\\nATOM 2212 CB ASN A 278 21.926 -1.625 -13.154 1.00 97.11 C \\\\nATOM 2213 O ASN A 278 21.821 1.276 -12.916 1.00 97.11 O \\\\nATOM 2214 CG ASN A 278 22.476 -3.007 -13.444 1.00 97.11 C \\\\nATOM 2215 ND2 ASN A 278 21.611 -3.949 -13.725 1.00 97.11 N \\\\nATOM 2216 OD1 ASN A 278 23.666 -3.263 -13.422 1.00 97.11 O \\\\nATOM 2217 N ARG A 279 21.996 1.027 -10.698 1.00 97.96 N \\\\nATOM 2218 CA ARG A 279 21.340 2.290 -10.366 1.00 97.96 C \\\\nATOM 2219 C ARG A 279 22.193 3.478 -10.809 1.00 97.96 C \\\\nATOM 2220 CB ARG A 279 21.060 2.312 -8.863 1.00 97.96 C \\\\nATOM 2221 O ARG A 279 23.320 3.644 -10.360 1.00 97.96 O \\\\nATOM 2222 CG ARG A 279 20.244 3.545 -8.475 1.00 97.96 C \\\\nATOM 2223 CD ARG A 279 19.859 3.495 -6.999 1.00 97.96 C \\\\nATOM 2224 NE ARG A 279 18.879 2.424 -6.746 1.00 97.96 N \\\\nATOM 2225 NH1 ARG A 279 19.536 1.773 -4.627 1.00 97.96 N \\\\nATOM 2226 NH2 ARG A 279 17.786 0.836 -5.597 1.00 97.96 N \\\\nATOM 2227 CZ ARG A 279 18.752 1.686 -5.665 1.00 97.96 C \\\\nATOM 2228 N ASN A 280 21.625 4.343 -11.646 1.00 98.01 N \\\\nATOM 2229 CA ASN A 280 22.284 5.575 -12.082 1.00 98.01 C \\\\nATOM 2230 C ASN A 280 21.891 6.792 -11.219 1.00 98.01 C \\\\nATOM 2231 CB ASN A 280 22.066 5.759 -13.597 1.00 98.01 C \\\\nATOM 2232 O ASN A 280 20.905 6.771 -10.476 1.00 98.01 O \\\\nATOM 2233 CG ASN A 280 20.659 6.171 -13.997 1.00 98.01 C \\\\nATOM 2234 ND2 ASN A 280 20.158 5.652 -15.090 1.00 98.01 N \\\\nATOM 2235 OD1 ASN A 280 20.010 6.991 -13.367 1.00 98.01 O \\\\nATOM 2236 N ALA A 281 22.632 7.894 -11.368 1.00 98.22 N \\\\nATOM 2237 CA ALA A 281 22.433 9.122 -10.594 1.00 98.22 C \\\\nATOM 2238 C ALA A 281 21.018 9.732 -10.717 1.00 98.22 C \\\\nATOM 2239 CB ALA A 281 23.501 10.127 -11.044 1.00 98.22 C \\\\nATOM 2240 O ALA A 281 20.518 10.328 -9.762 1.00 98.22 O \\\\nATOM 2241 N ALA A 282 20.339 9.570 -11.860 1.00 97.51 N \\\\nATOM 2242 CA ALA A 282 18.974 10.067 -12.047 1.00 97.51 C \\\\nATOM 2243 C ALA A 282 17.950 9.249 -11.239 1.00 97.51 C \\\\nATOM 2244 CB ALA A 282 18.643 10.075 -13.544 1.00 97.51 C \\\\nATOM 2245 O ALA A 282 16.999 9.815 -10.689 1.00 97.51 O \\\\nATOM 2246 N VAL A 283 18.165 7.934 -11.122 1.00 98.47 N \\\\nATOM 2247 CA VAL A 283 17.389 7.047 -10.245 1.00 98.47 C \\\\nATOM 2248 C VAL A 283 17.664 7.375 -8.778 1.00 98.47 C \\\\nATOM 2249 CB VAL A 283 17.676 5.565 -10.555 1.00 98.47 C \\\\nATOM 2250 O VAL A 283 16.717 7.591 -8.027 1.00 98.47 O \\\\nATOM 2251 CG1 VAL A 283 16.889 4.649 -9.617 1.00 98.47 C \\\\nATOM 2252 CG2 VAL A 283 17.304 5.177 -11.993 1.00 98.47 C \\\\nATOM 2253 N GLU A 284 18.928 7.516 -8.364 1.00 98.10 N \\\\nATOM 2254 CA GLU A 284 19.264 7.908 -6.985 1.00 98.10 C \\\\nATOM 2255 C GLU A 284 18.616 9.230 -6.565 1.00 98.10 C \\\\nATOM 2256 CB GLU A 284 20.767 8.100 -6.802 1.00 98.10 C \\\\nATOM 2257 O GLU A 284 18.015 9.320 -5.492 1.00 98.10 O \\\\nATOM 2258 CG GLU A 284 21.591 6.819 -6.912 1.00 98.10 C \\\\nATOM 2259 CD GLU A 284 23.012 7.033 -6.376 1.00 98.10 C \\\\nATOM 2260 OE1 GLU A 284 23.693 6.005 -6.206 1.00 98.10 O \\\\nATOM 2261 OE2 GLU A 284 23.355 8.200 -6.052 1.00 98.10 O \\\\nATOM 2262 N LEU A 285 18.712 10.256 -7.416 1.00 97.88 N \\\\nATOM 2263 CA LEU A 285 18.103 11.557 -7.160 1.00 97.88 C \\\\nATOM 2264 C LEU A 285 16.577 11.448 -7.064 1.00 97.88 C \\\\nATOM 2265 CB LEU A 285 18.540 12.528 -8.271 1.00 97.88 C \\\\nATOM 2266 O LEU A 285 15.972 12.091 -6.209 1.00 97.88 O \\\\nATOM 2267 CG LEU A 285 18.038 13.971 -8.080 1.00 97.88 C \\\\nATOM 2268 CD1 LEU A 285 18.614 14.620 -6.819 1.00 97.88 C \\\\nATOM 2269 CD2 LEU A 285 18.441 14.815 -9.287 1.00 97.88 C \\\\nATOM 2270 N THR A 286 15.953 10.614 -7.899 1.00 98.50 N \\\\nATOM 2271 CA THR A 286 14.501 10.386 -7.877 1.00 98.50 C \\\\nATOM 2272 C THR A 286 14.064 9.674 -6.596 1.00 98.50 C \\\\nATOM 2273 CB THR A 286 14.054 9.625 -9.133 1.00 98.50 C \\\\nATOM 2274 O THR A 286 13.122 10.129 -5.949 1.00 98.50 O \\\\nATOM 2275 CG2 THR A 286 12.547 9.397 -9.178 1.00 98.50 C \\\\nATOM 2276 OG1 THR A 286 14.390 10.398 -10.269 1.00 98.50 O \\\\nATOM 2277 N ARG A 287 14.794 8.638 -6.154 1.00 98.55 N \\\\nATOM 2278 CA ARG A 287 14.523 7.904 -4.901 1.00 98.55 C \\\\nATOM 2279 C ARG A 287 14.482 8.822 -3.678 1.00 98.55 C \\\\nATOM 2280 CB ARG A 287 15.564 6.790 -4.704 1.00 98.55 C \\\\nATOM 2281 O ARG A 287 13.576 8.694 -2.859 1.00 98.55 O \\\\nATOM 2282 CG ARG A 287 15.359 5.631 -5.690 1.00 98.55 C \\\\nATOM 2283 CD ARG A 287 16.531 4.646 -5.688 1.00 98.55 C \\\\nATOM 2284 NE ARG A 287 16.726 3.989 -4.382 1.00 98.55 N \\\\nATOM 2285 NH1 ARG A 287 15.047 2.408 -4.548 1.00 98.55 N \\\\nATOM 2286 NH2 ARG A 287 16.237 2.559 -2.695 1.00 98.55 N \\\\nATOM 2287 CZ ARG A 287 16.004 2.997 -3.893 1.00 98.55 C \\\\nATOM 2288 N ARG A 288 15.396 9.799 -3.592 1.00 98.14 N \\\\nATOM 2289 CA ARG A 288 15.428 10.806 -2.505 1.00 98.14 C \\\\nATOM 2290 C ARG A 288 14.143 11.644 -2.420 1.00 98.14 C \\\\nATOM 2291 CB ARG A 288 16.650 11.731 -2.667 1.00 98.14 C \\\\nATOM 2292 O ARG A 288 13.778 12.070 -1.332 1.00 98.14 O \\\\nATOM 2293 CG ARG A 288 17.993 11.000 -2.498 1.00 98.14 C \\\\nATOM 2294 CD ARG A 288 19.181 11.901 -2.874 1.00 98.14 C \\\\nATOM 2295 NE ARG A 288 20.398 11.107 -3.150 1.00 98.14 N \\\\nATOM 2296 NH1 ARG A 288 21.675 12.765 -4.097 1.00 98.14 N \\\\nATOM 2297 NH2 ARG A 288 22.412 10.662 -4.146 1.00 98.14 N \\\\nATOM 2298 CZ ARG A 288 21.488 11.511 -3.787 1.00 98.14 C \\\\nATOM 2299 N HIS A 289 13.449 11.845 -3.541 1.00 98.35 N \\\\nATOM 2300 CA HIS A 289 12.217 12.635 -3.628 1.00 98.35 C \\\\nATOM 2301 C HIS A 289 10.932 11.800 -3.487 1.00 98.35 C \\\\nATOM 2302 CB HIS A 289 12.228 13.443 -4.933 1.00 98.35 C \\\\nATOM 2303 O HIS A 289 9.845 12.371 -3.441 1.00 98.35 O \\\\nATOM 2304 CG HIS A 289 13.279 14.519 -4.971 1.00 98.35 C \\\\nATOM 2305 CD2 HIS A 289 13.114 15.837 -4.644 1.00 98.35 C \\\\nATOM 2306 ND1 HIS A 289 14.587 14.359 -5.363 1.00 98.35 N \\\\nATOM 2307 CE1 HIS A 289 15.198 15.549 -5.271 1.00 98.35 C \\\\nATOM 2308 NE2 HIS A 289 14.339 16.483 -4.845 1.00 98.35 N \\\\nATOM 2309 N ILE A 290 11.017 10.466 -3.369 1.00 98.63 N \\\\nATOM 2310 CA ILE A 290 9.841 9.639 -3.050 1.00 98.63 C \\\\nATOM 2311 C ILE A 290 9.306 10.043 -1.671 1.00 98.63 C \\\\nATOM 2312 CB ILE A 290 10.157 8.125 -3.141 1.00 98.63 C \\\\nATOM 2313 O ILE A 290 8.115 10.314 -1.533 1.00 98.63 O \\\\nATOM 2314 CG1 ILE A 290 10.603 7.762 -4.577 1.00 98.63 C \\\\nATOM 2315 CG2 ILE A 290 8.930 7.285 -2.733 1.00 98.63 C \\\\nATOM 2316 CD1 ILE A 290 11.006 6.296 -4.777 1.00 98.63 C \\\\nATOM 2317 N GLY A 291 10.179 10.159 -0.662 1.00 97.93 N \\\\nATOM 2318 CA GLY A 291 9.796 10.581 0.688 1.00 97.93 C \\\\nATOM 2319 C GLY A 291 8.689 9.692 1.258 1.00 97.93 C \\\\nATOM 2320 O GLY A 291 8.837 8.476 1.311 1.00 97.93 O \\\\nATOM 2321 N ARG A 292 7.549 10.284 1.631 1.00 97.98 N \\\\nATOM 2322 CA ARG A 292 6.356 9.552 2.107 1.00 97.98 C \\\\nATOM 2323 C ARG A 292 5.579 8.813 1.001 1.00 97.98 C \\\\nATOM 2324 CB ARG A 292 5.429 10.523 2.843 1.00 97.98 C \\\\nATOM 2325 O ARG A 292 4.648 8.084 1.323 1.00 97.98 O \\\\nATOM 2326 CG ARG A 292 6.043 11.155 4.102 1.00 97.98 C \\\\nATOM 2327 CD ARG A 292 5.155 12.291 4.625 1.00 97.98 C \\\\nATOM 2328 NE ARG A 292 3.816 11.807 5.025 1.00 97.98 N \\\\nATOM 2329 NH1 ARG A 292 2.560 13.478 4.052 1.00 97.98 N \\\\nATOM 2330 NH2 ARG A 292 1.550 11.850 5.190 1.00 97.98 N \\\\nATOM 2331 CZ ARG A 292 2.657 12.386 4.757 1.00 97.98 C \\\\nATOM 2332 N GLY A 293 5.940 9.013 -0.267 1.00 98.48 N \\\\nATOM 2333 CA GLY A 293 5.458 8.255 -1.421 1.00 98.48 C \\\\nATOM 2334 C GLY A 293 3.948 8.325 -1.660 1.00 98.48 C \\\\nATOM 2335 O GLY A 293 3.371 9.413 -1.711 1.00 98.48 O \\\\nATOM 2336 N VAL A 294 3.316 7.167 -1.851 1.00 98.76 N \\\\nATOM 2337 CA VAL A 294 1.883 7.027 -2.148 1.00 98.76 C \\\\nATOM 2338 C VAL A 294 1.199 6.162 -1.095 1.00 98.76 C \\\\nATOM 2339 CB VAL A 294 1.649 6.501 -3.583 1.00 98.76 C \\\\nATOM 2340 O VAL A 294 1.681 5.080 -0.764 1.00 98.76 O \\\\nATOM 2341 CG1 VAL A 294 2.258 5.122 -3.865 1.00 98.76 C \\\\nATOM 2342 CG2 VAL A 294 0.160 6.438 -3.941 1.00 98.76 C \\\\nATOM 2343 N ARG A 295 0.049 6.616 -0.588 1.00 98.09 N \\\\nATOM 2344 CA ARG A 295 -0.880 5.762 0.159 1.00 98.09 C \\\\nATOM 2345 C ARG A 295 -1.883 5.153 -0.811 1.00 98.09 C \\\\nATOM 2346 CB ARG A 295 -1.528 6.533 1.317 1.00 98.09 C \\\\nATOM 2347 O ARG A 295 -2.517 5.875 -1.576 1.00 98.09 O \\\\nATOM 2348 CG ARG A 295 -2.630 5.709 1.999 1.00 98.09 C \\\\nATOM 2349 CD ARG A 295 -3.123 6.304 3.319 1.00 98.09 C \\\\nATOM 2350 NE ARG A 295 -3.835 7.594 3.177 1.00 98.09 N \\\\nATOM 2351 NH1 ARG A 295 -4.351 7.823 5.400 1.00 98.09 N \\\\nATOM 2352 NH2 ARG A 295 -4.968 9.401 4.026 1.00 98.09 N \\\\nATOM 2353 CZ ARG A 295 -4.365 8.267 4.180 1.00 98.09 C \\\\nATOM 2354 N LEU A 296 -2.036 3.839 -0.738 1.00 98.08 N \\\\nATOM 2355 CA LEU A 296 -3.010 3.062 -1.490 1.00 98.08 C \\\\nATOM 2356 C LEU A 296 -4.043 2.516 -0.509 1.00 98.08 C \\\\nATOM 2357 CB LEU A 296 -2.294 1.924 -2.231 1.00 98.08 C \\\\nATOM 2358 O LEU A 296 -3.667 2.012 0.551 1.00 98.08 O \\\\nATOM 2359 CG LEU A 296 -1.248 2.381 -3.261 1.00 98.08 C \\\\nATOM 2360 CD1 LEU A 296 -0.411 1.178 -3.685 1.00 98.08 C \\\\nATOM 2361 CD2 LEU A 296 -1.904 3.007 -4.492 1.00 98.08 C \\\\nATOM 2362 N TYR A 297 -5.329 2.623 -0.832 1.00 95.51 N \\\\nATOM 2363 CA TYR A 297 -6.385 2.059 0.007 1.00 95.51 C \\\\nATOM 2364 C TYR A 297 -7.529 1.468 -0.814 1.00 95.51 C \\\\nATOM 2365 CB TYR A 297 -6.864 3.077 1.057 1.00 95.51 C \\\\nATOM 2366 O TYR A 297 -7.959 2.065 -1.801 1.00 95.51 O \\\\nATOM 2367 CG TYR A 297 -7.340 4.429 0.545 1.00 95.51 C \\\\nATOM 2368 CD1 TYR A 297 -6.414 5.466 0.324 1.00 95.51 C \\\\nATOM 2369 CD2 TYR A 297 -8.708 4.666 0.320 1.00 95.51 C \\\\nATOM 2370 CE1 TYR A 297 -6.849 6.736 -0.100 1.00 95.51 C \\\\nATOM 2371 CE2 TYR A 297 -9.157 5.940 -0.083 1.00 95.51 C \\\\nATOM 2372 OH TYR A 297 -8.632 8.188 -0.768 1.00 95.51 O \\\\nATOM 2373 CZ TYR A 297 -8.223 6.975 -0.311 1.00 95.51 C \\\\nATOM 2374 N TYR A 298 -8.002 0.301 -0.375 1.00 94.74 N \\\\nATOM 2375 CA TYR A 298 -9.119 -0.454 -0.933 1.00 94.74 C \\\\nATOM 2376 C TYR A 298 -10.305 -0.400 0.031 1.00 94.74 C \\\\nATOM 2377 CB TYR A 298 -8.687 -1.901 -1.202 1.00 94.74 C \\\\nATOM 2378 O TYR A 298 -10.216 -0.871 1.165 1.00 94.74 O \\\\nATOM 2379 CG TYR A 298 -9.816 -2.794 -1.687 1.00 94.74 C \\\\nATOM 2380 CD1 TYR A 298 -10.159 -3.964 -0.979 1.00 94.74 C \\\\nATOM 2381 CD2 TYR A 298 -10.533 -2.448 -2.849 1.00 94.74 C \\\\nATOM 2382 CE1 TYR A 298 -11.210 -4.787 -1.436 1.00 94.74 C \\\\nATOM 2383 CE2 TYR A 298 -11.572 -3.276 -3.314 1.00 94.74 C \\\\nATOM 2384 OH TYR A 298 -12.949 -5.212 -3.055 1.00 94.74 O \\\\nATOM 2385 CZ TYR A 298 -11.919 -4.446 -2.607 1.00 94.74 C \\\\nATOM 2386 N ILE A 299 -11.394 0.244 -0.388 1.00 91.25 N \\\\nATOM 2387 CA ILE A 299 -12.558 0.535 0.455 1.00 91.25 C \\\\nATOM 2388 C ILE A 299 -13.815 0.469 -0.405 1.00 91.25 C \\\\nATOM 2389 CB ILE A 299 -12.423 1.927 1.118 1.00 91.25 C \\\\nATOM 2390 O ILE A 299 -13.893 1.129 -1.436 1.00 91.25 O \\\\nATOM 2391 CG1 ILE A 299 -11.142 1.993 1.981 1.00 91.25 C \\\\nATOM 2392 CG2 ILE A 299 -13.670 2.255 1.966 1.00 91.25 C \\\\nATOM 2393 CD1 ILE A 299 -10.920 3.332 2.662 1.00 91.25 C \\\\nATOM 2394 N GLY A 300 -14.817 -0.298 0.027 1.00 87.74 N \\\\nATOM 2395 CA GLY A 300 -16.122 -0.324 -0.635 1.00 87.74 C \\\\nATOM 2396 C GLY A 300 -16.095 -0.843 -2.079 1.00 87.74 C \\\\nATOM 2397 O GLY A 300 -16.918 -0.420 -2.883 1.00 87.74 O \\\\nATOM 2398 N GLY A 301 -15.134 -1.703 -2.439 1.00 92.50 N \\\\nATOM 2399 CA GLY A 301 -14.932 -2.138 -3.827 1.00 92.50 C \\\\nATOM 2400 C GLY A 301 -14.189 -1.123 -4.709 1.00 92.50 C \\\\nATOM 2401 O GLY A 301 -14.130 -1.302 -5.923 1.00 92.50 O \\\\nATOM 2402 N GLU A 302 -13.621 -0.061 -4.133 1.00 96.35 N \\\\nATOM 2403 CA GLU A 302 -12.888 0.985 -4.850 1.00 96.35 C \\\\nATOM 2404 C GLU A 302 -11.437 1.070 -4.369 1.00 96.35 C \\\\nATOM 2405 CB GLU A 302 -13.577 2.348 -4.682 1.00 96.35 C \\\\nATOM 2406 O GLU A 302 -11.167 0.962 -3.172 1.00 96.35 O \\\\nATOM 2407 CG GLU A 302 -15.088 2.312 -4.939 1.00 96.35 C \\\\nATOM 2408 CD GLU A 302 -15.652 3.709 -5.205 1.00 96.35 C \\\\nATOM 2409 OE1 GLU A 302 -16.276 3.889 -6.275 1.00 96.35 O \\\\nATOM 2410 OE2 GLU A 302 -15.407 4.677 -4.447 1.00 96.35 O \\\\nATOM 2411 N VAL A 303 -10.497 1.306 -5.288 1.00 97.65 N \\\\nATOM 2412 CA VAL A 303 -9.086 1.555 -4.958 1.00 97.65 C \\\\nATOM 2413 C VAL A 303 -8.758 3.017 -5.223 1.00 97.65 C \\\\nATOM 2414 CB VAL A 303 -8.101 0.632 -5.703 1.00 97.65 C \\\\nATOM 2415 O VAL A 303 -9.085 3.566 -6.279 1.00 97.65 O \\\\nATOM 2416 CG1 VAL A 303 -6.685 0.759 -5.122 1.00 97.65 C \\\\nATOM 2417 CG2 VAL A 303 -8.473 -0.853 -5.616 1.00 97.65 C \\\\nATOM 2418 N PHE A 304 -8.050 3.639 -4.287 1.00 98.07 N \\\\nATOM 2419 CA PHE A 304 -7.582 5.017 -4.387 1.00 98.07 C \\\\nATOM 2420 C PHE A 304 -6.065 5.109 -4.219 1.00 98.07 C \\\\nATOM 2421 CB PHE A 304 -8.259 5.861 -3.314 1.00 98.07 C \\\\nATOM 2422 O PHE A 304 -5.465 4.343 -3.462 1.00 98.07 O \\\\nATOM 2423 CG PHE A 304 -9.768 5.994 -3.396 1.00 98.07 C \\\\nATOM 2424 CD1 PHE A 304 -10.346 7.178 -3.895 1.00 98.07 C \\\\nATOM 2425 CD2 PHE A 304 -10.598 4.970 -2.898 1.00 98.07 C \\\\nATOM 2426 CE1 PHE A 304 -11.745 7.331 -3.908 1.00 98.07 C \\\\nATOM 2427 CE2 PHE A 304 -11.993 5.130 -2.902 1.00 98.07 C \\\\nATOM 2428 CZ PHE A 304 -12.568 6.303 -3.416 1.00 98.07 C \\\\nATOM 2429 N ALA A 305 -5.465 6.102 -4.876 1.00 98.57 N \\\\nATOM 2430 CA ALA A 305 -4.087 6.528 -4.654 1.00 98.57 C \\\\nATOM 2431 C ALA A 305 -4.061 7.952 -4.097 1.00 98.57 C \\\\nATOM 2432 CB ALA A 305 -3.307 6.433 -5.966 1.00 98.57 C \\\\nATOM 2433 O ALA A 305 -4.728 8.836 -4.629 1.00 98.57 O \\\\nATOM 2434 N GLU A 306 -3.273 8.188 -3.053 1.00 98.38 N \\\\nATOM 2435 CA GLU A 306 -3.106 9.485 -2.395 1.00 98.38 C \\\\nATOM 2436 C GLU A 306 -1.620 9.847 -2.324 1.00 98.38 C \\\\nATOM 2437 CB GLU A 306 -3.768 9.411 -1.014 1.00 98.38 C \\\\nATOM 2438 O GLU A 306 -0.812 9.109 -1.754 1.00 98.38 O \\\\nATOM 2439 CG GLU A 306 -3.686 10.690 -0.165 1.00 98.38 C \\\\nATOM 2440 CD GLU A 306 -4.307 10.462 1.224 1.00 98.38 C \\\\nATOM 2441 OE1 GLU A 306 -3.891 11.102 2.218 1.00 98.38 O \\\\nATOM 2442 OE2 GLU A 306 -5.160 9.553 1.396 1.00 98.38 O \\\\nATOM 2443 N CYS A 307 -1.250 10.987 -2.907 1.00 98.55 N \\\\nATOM 2444 CA CYS A 307 0.134 11.440 -2.960 1.00 98.55 C \\\\nATOM 2445 C CYS A 307 0.551 12.019 -1.602 1.00 98.55 C \\\\nATOM 2446 CB CYS A 307 0.277 12.448 -4.103 1.00 98.55 C \\\\nATOM 2447 O CYS A 307 0.202 13.148 -1.256 1.00 98.55 O \\\\nATOM 2448 SG CYS A 307 2.033 12.800 -4.388 1.00 98.55 S \\\\nATOM 2449 N LEU A 308 1.309 11.243 -0.824 1.00 98.21 N \\\\nATOM 2450 CA LEU A 308 1.869 11.676 0.458 1.00 98.21 C \\\\nATOM 2451 C LEU A 308 3.240 12.351 0.316 1.00 98.21 C \\\\nATOM 2452 CB LEU A 308 1.971 10.471 1.404 1.00 98.21 C \\\\nATOM 2453 O LEU A 308 3.667 13.040 1.247 1.00 98.21 O \\\\nATOM 2454 CG LEU A 308 0.651 9.781 1.786 1.00 98.21 C \\\\nATOM 2455 CD1 LEU A 308 0.945 8.821 2.942 1.00 98.21 C \\\\nATOM 2456 CD2 LEU A 308 -0.428 10.758 2.256 1.00 98.21 C \\\\nATOM 2457 N SER A 309 3.918 12.113 -0.808 1.00 98.38 N \\\\nATOM 2458 CA SER A 309 5.160 12.764 -1.220 1.00 98.38 C \\\\nATOM 2459 C SER A 309 4.962 14.255 -1.504 1.00 98.38 C \\\\nATOM 2460 CB SER A 309 5.692 12.085 -2.486 1.00 98.38 C \\\\nATOM 2461 O SER A 309 3.910 14.669 -1.993 1.00 98.38 O \\\\nATOM 2462 OG SER A 309 6.949 12.629 -2.837 1.00 98.38 O \\\\nATOM 2463 N ASP A 310 6.018 15.035 -1.266 1.00 98.37 N \\\\nATOM 2464 CA ASP A 310 6.132 16.441 -1.669 1.00 98.37 C \\\\nATOM 2465 C ASP A 310 6.377 16.594 -3.189 1.00 98.37 C \\\\nATOM 2466 CB ASP A 310 7.257 17.105 -0.855 1.00 98.37 C \\\\nATOM 2467 O ASP A 310 6.329 17.696 -3.731 1.00 98.37 O \\\\nATOM 2468 CG ASP A 310 7.108 16.885 0.657 1.00 98.37 C \\\\nATOM 2469 OD1 ASP A 310 6.020 17.183 1.199 1.00 98.37 O \\\\nATOM 2470 OD2 ASP A 310 8.070 16.356 1.258 1.00 98.37 O \\\\nATOM 2471 N SER A 311 6.618 15.485 -3.899 1.00 98.40 N \\\\nATOM 2472 CA SER A 311 6.662 15.398 -5.363 1.00 98.40 C \\\\nATOM 2473 C SER A 311 5.446 14.649 -5.905 1.00 98.40 C \\\\nATOM 2474 CB SER A 311 7.935 14.680 -5.804 1.00 98.40 C \\\\nATOM 2475 O SER A 311 5.000 13.672 -5.314 1.00 98.40 O \\\\nATOM 2476 OG SER A 311 9.054 15.498 -5.541 1.00 98.40 O \\\\nATOM 2477 N ALA A 312 4.929 15.070 -7.062 1.00 98.66 N \\\\nATOM 2478 CA ALA A 312 3.782 14.415 -7.693 1.00 98.66 C \\\\nATOM 2479 C ALA A 312 4.071 12.953 -8.088 1.00 98.66 C \\\\nATOM 2480 CB ALA A 312 3.342 15.240 -8.910 1.00 98.66 C \\\\nATOM 2481 O ALA A 312 5.201 12.598 -8.445 1.00 98.66 O \\\\nATOM 2482 N ILE A 313 3.015 12.141 -8.102 1.00 98.82 N \\\\nATOM 2483 CA ILE A 313 2.999 10.804 -8.707 1.00 98.82 C \\\\nATOM 2484 C ILE A 313 2.170 10.823 -9.996 1.00 98.82 C \\\\nATOM 2485 CB ILE A 313 2.538 9.719 -7.707 1.00 98.82 C \\\\nATOM 2486 O ILE A 313 1.347 11.714 -10.212 1.00 98.82 O \\\\nATOM 2487 CG1 ILE A 313 1.073 9.935 -7.277 1.00 98.82 C \\\\nATOM 2488 CG2 ILE A 313 3.504 9.665 -6.509 1.00 98.82 C \\\\nATOM 2489 CD1 ILE A 313 0.539 8.921 -6.265 1.00 98.82 C \\\\nATOM 2490 N PHE A 314 2.401 9.848 -10.865 1.00 98.73 N \\\\nATOM 2491 CA PHE A 314 1.799 9.763 -12.195 1.00 98.73 C \\\\nATOM 2492 C PHE A 314 1.232 8.361 -12.370 1.00 98.73 C \\\\nATOM 2493 CB PHE A 314 2.873 10.087 -13.242 1.00 98.73 C \\\\nATOM 2494 O PHE A 314 1.959 7.403 -12.131 1.00 98.73 O \\\\nATOM 2495 CG PHE A 314 3.483 11.464 -13.086 1.00 98.73 C \\\\nATOM 2496 CD1 PHE A 314 2.991 12.550 -13.832 1.00 98.73 C \\\\nATOM 2497 CD2 PHE A 314 4.534 11.664 -12.170 1.00 98.73 C \\\\nATOM 2498 CE1 PHE A 314 3.556 13.826 -13.660 1.00 98.73 C \\\\nATOM 2499 CE2 PHE A 314 5.066 12.949 -11.972 1.00 98.73 C \\\\nATOM 2500 CZ PHE A 314 4.588 14.029 -12.729 1.00 98.73 C \\\\nATOM 2501 N VAL A 315 -0.044 8.232 -12.728 1.00 98.59 N \\\\nATOM 2502 CA VAL A 315 -0.794 6.970 -12.686 1.00 98.59 C \\\\nATOM 2503 C VAL A 315 -1.401 6.660 -14.047 1.00 98.59 C \\\\nATOM 2504 CB VAL A 315 -1.905 7.017 -11.616 1.00 98.59 C \\\\nATOM 2505 O VAL A 315 -2.157 7.463 -14.581 1.00 98.59 O \\\\nATOM 2506 CG1 VAL A 315 -2.648 5.676 -11.526 1.00 98.59 C \\\\nATOM 2507 CG2 VAL A 315 -1.334 7.361 -10.232 1.00 98.59 C \\\\nATOM 2508 N GLN A 316 -1.131 5.467 -14.567 1.00 98.50 N \\\\nATOM 2509 CA GLN A 316 -1.849 4.879 -15.694 1.00 98.50 C \\\\nATOM 2510 C GLN A 316 -2.736 3.760 -15.142 1.00 98.50 C \\\\nATOM 2511 CB GLN A 316 -0.823 4.384 -16.721 1.00 98.50 C \\\\nATOM 2512 O GLN A 316 -2.234 2.719 -14.716 1.00 98.50 O \\\\nATOM 2513 CG GLN A 316 -1.429 3.791 -17.999 1.00 98.50 C \\\\nATOM 2514 CD GLN A 316 -0.336 3.221 -18.902 1.00 98.50 C \\\\nATOM 2515 NE2 GLN A 316 -0.040 3.836 -20.027 1.00 98.50 N \\\\nATOM 2516 OE1 GLN A 316 0.309 2.230 -18.589 1.00 98.50 O \\\\nATOM 2517 N SER A 317 -4.049 3.996 -15.117 1.00 98.39 N \\\\nATOM 2518 CA SER A 317 -5.060 2.984 -14.795 1.00 98.39 C \\\\nATOM 2519 C SER A 317 -6.089 2.946 -15.923 1.00 98.39 C \\\\nATOM 2520 CB SER A 317 -5.762 3.277 -13.467 1.00 98.39 C \\\\nATOM 2521 O SER A 317 -6.858 3.903 -16.054 1.00 98.39 O \\\\nATOM 2522 OG SER A 317 -6.874 2.408 -13.353 1.00 98.39 O \\\\nATOM 2523 N PRO A 318 -6.152 1.862 -16.715 1.00 97.77 N \\\\nATOM 2524 CA PRO A 318 -7.133 1.740 -17.789 1.00 97.77 C \\\\nATOM 2525 C PRO A 318 -8.589 1.853 -17.303 1.00 97.77 C \\\\nATOM 2526 CB PRO A 318 -6.821 0.396 -18.446 1.00 97.77 C \\\\nATOM 2527 O PRO A 318 -9.390 2.516 -17.953 1.00 97.77 O \\\\nATOM 2528 CG PRO A 318 -5.322 0.232 -18.214 1.00 97.77 C \\\\nATOM 2529 CD PRO A 318 -5.171 0.786 -16.801 1.00 97.77 C \\\\nATOM 2530 N ASN A 319 -8.918 1.326 -16.113 1.00 97.99 N \\\\nATOM 2531 CA ASN A 319 -10.244 1.493 -15.496 1.00 97.99 C \\\\nATOM 2532 C ASN A 319 -10.566 2.966 -15.183 1.00 97.99 C \\\\nATOM 2533 CB ASN A 319 -10.309 0.611 -14.236 1.00 97.99 C \\\\nATOM 2534 O ASN A 319 -11.661 3.438 -15.478 1.00 97.99 O \\\\nATOM 2535 CG ASN A 319 -11.614 0.775 -13.470 1.00 97.99 C \\\\nATOM 2536 ND2 ASN A 319 -12.663 0.081 -13.837 1.00 97.99 N \\\\nATOM 2537 OD1 ASN A 319 -11.698 1.547 -12.527 1.00 97.99 O \\\\nATOM 2538 N CYS A 320 -9.600 3.715 -14.641 1.00 97.61 N \\\\nATOM 2539 CA CYS A 320 -9.765 5.149 -14.404 1.00 97.61 C \\\\nATOM 2540 C CYS A 320 -9.915 5.926 -15.721 1.00 97.61 C \\\\nATOM 2541 CB CYS A 320 -8.560 5.644 -13.598 1.00 97.61 C \\\\nATOM 2542 O CYS A 320 -10.769 6.803 -15.818 1.00 97.61 O \\\\nATOM 2543 SG CYS A 320 -8.805 7.360 -13.069 1.00 97.61 S \\\\nATOM 2544 N ASN A 321 -9.107 5.597 -16.730 1.00 97.67 N \\\\nATOM 2545 CA ASN A 321 -9.126 6.263 -18.030 1.00 97.67 C \\\\nATOM 2546 C ASN A 321 -10.470 6.049 -18.742 1.00 97.67 C \\\\nATOM 2547 CB ASN A 321 -7.913 5.779 -18.849 1.00 97.67 C \\\\nATOM 2548 O ASN A 321 -11.088 7.022 -19.169 1.00 97.67 O \\\\nATOM 2549 CG ASN A 321 -6.587 6.264 -18.280 1.00 97.67 C \\\\nATOM 2550 ND2 ASN A 321 -5.481 5.659 -18.640 1.00 97.67 N \\\\nATOM 2551 OD1 ASN A 321 -6.511 7.213 -17.517 1.00 97.67 O \\\\nATOM 2552 N GLN A 322 -10.981 4.814 -18.757 1.00 96.68 N \\\\nATOM 2553 CA GLN A 322 -12.291 4.489 -19.322 1.00 96.68 C \\\\nATOM 2554 C GLN A 322 -13.438 5.228 -18.615 1.00 96.68 C \\\\nATOM 2555 CB GLN A 322 -12.479 2.967 -19.285 1.00 96.68 C \\\\nATOM 2556 O GLN A 322 -14.307 5.769 -19.296 1.00 96.68 O \\\\nATOM 2557 CG GLN A 322 -13.796 2.518 -19.940 1.00 96.68 C \\\\nATOM 2558 CD GLN A 322 -13.909 1.001 -20.053 1.00 96.68 C \\\\nATOM 2559 NE2 GLN A 322 -15.063 0.474 -20.393 1.00 96.68 N \\\\nATOM 2560 OE1 GLN A 322 -12.970 0.258 -19.833 1.00 96.68 O \\\\nATOM 2561 N ARG A 323 -13.426 5.330 -17.274 1.00 96.89 N \\\\nATOM 2562 CA ARG A 323 -14.443 6.083 -16.507 1.00 96.89 C \\\\nATOM 2563 C ARG A 323 -14.564 7.543 -16.958 1.00 96.89 C \\\\nATOM 2564 CB ARG A 323 -14.107 6.024 -15.006 1.00 96.89 C \\\\nATOM 2565 O ARG A 323 -15.663 8.090 -16.961 1.00 96.89 O \\\\nATOM 2566 CG ARG A 323 -15.199 6.657 -14.117 1.00 96.89 C \\\\nATOM 2567 CD ARG A 323 -14.716 6.904 -12.685 1.00 96.89 C \\\\nATOM 2568 NE ARG A 323 -14.325 5.643 -12.043 1.00 96.89 N \\\\nATOM 2569 NH1 ARG A 323 -12.182 6.137 -11.428 1.00 96.89 N \\\\nATOM 2570 NH2 ARG A 323 -12.918 4.017 -11.386 1.00 96.89 N \\\\nATOM 2571 CZ ARG A 323 -13.140 5.272 -11.615 1.00 96.89 C \\\\nATOM 2572 N TYR A 324 -13.446 8.175 -17.312 1.00 96.60 N \\\\nATOM 2573 CA TYR A 324 -13.397 9.579 -17.733 1.00 96.60 C \\\\nATOM 2574 C TYR A 324 -13.390 9.773 -19.261 1.00 96.60 C \\\\nATOM 2575 CB TYR A 324 -12.221 10.278 -17.032 1.00 96.60 C \\\\nATOM 2576 O TYR A 324 -13.228 10.900 -19.721 1.00 96.60 O \\\\nATOM 2577 CG TYR A 324 -12.352 10.360 -15.519 1.00 96.60 C \\\\nATOM 2578 CD1 TYR A 324 -13.401 11.106 -14.946 1.00 96.60 C \\\\nATOM 2579 CD2 TYR A 324 -11.424 9.710 -14.684 1.00 96.60 C \\\\nATOM 2580 CE1 TYR A 324 -13.535 11.186 -13.547 1.00 96.60 C \\\\nATOM 2581 CE2 TYR A 324 -11.555 9.779 -13.283 1.00 96.60 C \\\\nATOM 2582 OH TYR A 324 -12.750 10.575 -11.362 1.00 96.60 O \\\\nATOM 2583 CZ TYR A 324 -12.613 10.515 -12.714 1.00 96.60 C \\\\nATOM 2584 N GLY A 325 -13.566 8.706 -20.052 1.00 96.83 N \\\\nATOM 2585 CA GLY A 325 -13.546 8.778 -21.518 1.00 96.83 C \\\\nATOM 2586 C GLY A 325 -12.171 9.110 -22.114 1.00 96.83 C \\\\nATOM 2587 O GLY A 325 -12.085 9.595 -23.239 1.00 96.83 O \\\\nATOM 2588 N TRP A 326 -11.088 8.885 -21.368 1.00 96.86 N \\\\nATOM 2589 CA TRP A 326 -9.719 9.104 -21.832 1.00 96.86 C \\\\nATOM 2590 C TRP A 326 -9.160 7.863 -22.529 1.00 96.86 C \\\\nATOM 2591 CB TRP A 326 -8.824 9.520 -20.657 1.00 96.86 C \\\\nATOM 2592 O TRP A 326 -9.530 6.733 -22.211 1.00 96.86 O \\\\nATOM 2593 CG TRP A 326 -9.208 10.774 -19.932 1.00 96.86 C \\\\nATOM 2594 CD1 TRP A 326 -9.869 11.827 -20.467 1.00 96.86 C \\\\nATOM 2595 CD2 TRP A 326 -9.012 11.108 -18.521 1.00 96.86 C \\\\nATOM 2596 CE2 TRP A 326 -9.585 12.393 -18.279 1.00 96.86 C \\\\nATOM 2597 CE3 TRP A 326 -8.445 10.441 -17.410 1.00 96.86 C \\\\nATOM 2598 NE1 TRP A 326 -10.085 12.785 -19.500 1.00 96.86 N \\\\nATOM 2599 CH2 TRP A 326 -9.046 12.288 -15.922 1.00 96.86 C \\\\nATOM 2600 CZ2 TRP A 326 -9.597 12.988 -17.008 1.00 96.86 C \\\\nATOM 2601 CZ3 TRP A 326 -8.480 11.017 -16.125 1.00 96.86 C \\\\nATOM 2602 N HIS A 327 -8.192 8.071 -23.429 1.00 96.47 N \\\\nATOM 2603 CA HIS A 327 -7.456 6.975 -24.059 1.00 96.47 C \\\\nATOM 2604 C HIS A 327 -6.885 6.008 -22.993 1.00 96.47 C \\\\nATOM 2605 CB HIS A 327 -6.341 7.555 -24.942 1.00 96.47 C \\\\nATOM 2606 O HIS A 327 -6.330 6.481 -21.996 1.00 96.47 O \\\\nATOM 2607 CG HIS A 327 -5.666 6.498 -25.775 1.00 96.47 C \\\\nATOM 2608 CD2 HIS A 327 -6.181 5.901 -26.894 1.00 96.47 C \\\\nATOM 2609 ND1 HIS A 327 -4.451 5.902 -25.523 1.00 96.47 N \\\\nATOM 2610 CE1 HIS A 327 -4.247 4.955 -26.458 1.00 96.47 C \\\\nATOM 2611 NE2 HIS A 327 -5.285 4.912 -27.299 1.00 96.47 N \\\\nATOM 2612 N PRO A 328 -6.948 4.670 -23.168 1.00 94.55 N \\\\nATOM 2613 CA PRO A 328 -6.511 3.714 -22.142 1.00 94.55 C \\\\nATOM 2614 C PRO A 328 -5.063 3.912 -21.667 1.00 94.55 C \\\\nATOM 2615 CB PRO A 328 -6.707 2.331 -22.770 1.00 94.55 C \\\\nATOM 2616 O PRO A 328 -4.744 3.622 -20.514 1.00 94.55 O \\\\nATOM 2617 CG PRO A 328 -7.873 2.550 -23.731 1.00 94.55 C \\\\nATOM 2618 CD PRO A 328 -7.614 3.961 -24.254 1.00 94.55 C \\\\nATOM 2619 N ALA A 329 -4.203 4.470 -22.525 1.00 95.38 N \\\\nATOM 2620 CA ALA A 329 -2.805 4.780 -22.223 1.00 95.38 C \\\\nATOM 2621 C ALA A 329 -2.573 6.023 -21.339 1.00 95.38 C \\\\nATOM 2622 CB ALA A 329 -2.057 4.963 -23.546 1.00 95.38 C \\\\nATOM 2623 O ALA A 329 -1.431 6.232 -20.922 1.00 95.38 O \\\\nATOM 2624 N THR A 330 -3.592 6.859 -21.101 1.00 97.03 N \\\\nATOM 2625 CA THR A 330 -3.469 8.168 -20.437 1.00 97.03 C \\\\nATOM 2626 C THR A 330 -2.818 8.070 -19.056 1.00 97.03 C \\\\nATOM 2627 CB THR A 330 -4.839 8.868 -20.371 1.00 97.03 C \\\\nATOM 2628 O THR A 330 -3.058 7.131 -18.293 1.00 97.03 O \\\\nATOM 2629 CG2 THR A 330 -4.888 10.148 -19.534 1.00 97.03 C \\\\nATOM 2630 OG1 THR A 330 -5.162 9.258 -21.682 1.00 97.03 O \\\\nATOM 2631 N VAL A 331 -1.977 9.059 -18.743 1.00 98.32 N \\\\nATOM 2632 CA VAL A 331 -1.197 9.127 -17.503 1.00 98.32 C \\\\nATOM 2633 C VAL A 331 -1.662 10.319 -16.667 1.00 98.32 C \\\\nATOM 2634 CB VAL A 331 0.314 9.177 -17.801 1.00 98.32 C \\\\nATOM 2635 O VAL A 331 -1.331 11.473 -16.939 1.00 98.32 O \\\\nATOM 2636 CG1 VAL A 331 1.119 9.167 -16.496 1.00 98.32 C \\\\nATOM 2637 CG2 VAL A 331 0.754 7.971 -18.641 1.00 98.32 C \\\\nATOM 2638 N CYS A 332 -2.424 10.038 -15.616 1.00 97.93 N \\\\nATOM 2639 CA CYS A 332 -2.985 11.032 -14.711 1.00 97.93 C \\\\nATOM 2640 C CYS A 332 -1.943 11.484 -13.678 1.00 97.93 C \\\\nATOM 2641 CB CYS A 332 -4.212 10.433 -14.013 1.00 97.93 C \\\\nATOM 2642 O CYS A 332 -1.425 10.677 -12.904 1.00 97.93 O \\\\nATOM 2643 SG CYS A 332 -5.401 9.801 -15.228 1.00 97.93 S \\\\nATOM 2644 N LYS A 333 -1.662 12.786 -13.603 1.00 98.40 N \\\\nATOM 2645 CA LYS A 333 -0.823 13.367 -12.544 1.00 98.40 C \\\\nATOM 2646 C LYS A 333 -1.639 13.558 -11.262 1.00 98.40 C \\\\nATOM 2647 CB LYS A 333 -0.231 14.684 -13.062 1.00 98.40 C \\\\nATOM 2648 O LYS A 333 -2.661 14.236 -11.287 1.00 98.40 O \\\\nATOM 2649 CG LYS A 333 0.684 15.383 -12.046 1.00 98.40 C \\\\nATOM 2650 CD LYS A 333 1.203 16.686 -12.664 1.00 98.40 C \\\\nATOM 2651 CE LYS A 333 2.105 17.450 -11.694 1.00 98.40 C \\\\nATOM 2652 NZ LYS A 333 2.527 18.742 -12.291 1.00 98.40 N \\\\nATOM 2653 N ILE A 334 -1.145 13.050 -10.134 1.00 98.51 N \\\\nATOM 2654 CA ILE A 334 -1.685 13.314 -8.792 1.00 98.51 C \\\\nATOM 2655 C ILE A 334 -0.687 14.224 -8.050 1.00 98.51 C \\\\nATOM 2656 CB ILE A 334 -1.975 12.007 -8.019 1.00 98.51 C \\\\nATOM 2657 O ILE A 334 0.409 13.772 -7.703 1.00 98.51 O \\\\nATOM 2658 CG1 ILE A 334 -2.838 11.022 -8.842 1.00 98.51 C \\\\nATOM 2659 CG2 ILE A 334 -2.655 12.336 -6.674 1.00 98.51 C \\\\nATOM 2660 CD1 ILE A 334 -3.066 9.673 -8.151 1.00 98.51 C \\\\nATOM 2661 N PRO A 335 -1.013 15.514 -7.831 1.00 98.57 N \\\\nATOM 2662 CA PRO A 335 -0.159 16.433 -7.078 1.00 98.57 C \\\\nATOM 2663 C PRO A 335 -0.027 16.061 -5.586 1.00 98.57 C \\\\nATOM 2664 CB PRO A 335 -0.788 17.823 -7.244 1.00 98.57 C \\\\nATOM 2665 O PRO A 335 -0.885 15.351 -5.057 1.00 98.57 O \\\\nATOM 2666 CG PRO A 335 -1.649 17.696 -8.499 1.00 98.57 C \\\\nATOM 2667 CD PRO A 335 -2.117 16.247 -8.435 1.00 98.57 C \\\\nATOM 2668 N PRO A 336 0.997 16.579 -4.880 1.00 98.51 N \\\\nATOM 2669 CA PRO A 336 1.147 16.432 -3.429 1.00 98.51 C \\\\nATOM 2670 C PRO A 336 -0.131 16.770 -2.651 1.00 98.51 C \\\\nATOM 2671 CB PRO A 336 2.291 17.377 -3.044 1.00 98.51 C \\\\nATOM 2672 O PRO A 336 -0.737 17.819 -2.856 1.00 98.51 O \\\\nATOM 2673 CG PRO A 336 3.155 17.374 -4.300 1.00 98.51 C \\\\nATOM 2674 CD PRO A 336 2.115 17.342 -5.414 1.00 98.51 C \\\\nATOM 2675 N GLY A 337 -0.549 15.876 -1.752 1.00 95.96 N \\\\nATOM 2676 CA GLY A 337 -1.767 16.020 -0.948 1.00 95.96 C \\\\nATOM 2677 C GLY A 337 -3.084 15.715 -1.678 1.00 95.96 C \\\\nATOM 2678 O GLY A 337 -4.129 15.661 -1.028 1.00 95.96 O \\\\nATOM 2679 N CYS A 338 -3.066 15.485 -2.994 1.00 97.97 N \\\\nATOM 2680 CA CYS A 338 -4.239 15.055 -3.755 1.00 97.97 C \\\\nATOM 2681 C CYS A 338 -4.426 13.529 -3.706 1.00 97.97 C \\\\nATOM 2682 CB CYS A 338 -4.149 15.568 -5.200 1.00 97.97 C \\\\nATOM 2683 O CYS A 338 -3.501 12.769 -3.408 1.00 97.97 O \\\\nATOM 2684 SG CYS A 338 -4.101 17.385 -5.234 1.00 97.97 S \\\\nATOM 2685 N ASN A 339 -5.636 13.079 -4.040 1.00 97.19 N \\\\nATOM 2686 CA ASN A 339 -5.968 11.670 -4.234 1.00 97.19 C \\\\nATOM 2687 C ASN A 339 -6.816 11.470 -5.499 1.00 97.19 C \\\\nATOM 2688 CB ASN A 339 -6.641 11.094 -2.973 1.00 97.19 C \\\\nATOM 2689 O ASN A 339 -7.424 12.420 -5.991 1.00 97.19 O \\\\nATOM 2690 CG ASN A 339 -8.006 11.697 -2.697 1.00 97.19 C \\\\nATOM 2691 ND2 ASN A 339 -8.068 12.787 -1.966 1.00 97.19 N \\\\nATOM 2692 OD1 ASN A 339 -9.032 11.213 -3.137 1.00 97.19 O \\\\nATOM 2693 N LEU A 340 -6.834 10.241 -6.013 1.00 97.74 N \\\\nATOM 2694 CA LEU A 340 -7.588 9.821 -7.194 1.00 97.74 C \\\\nATOM 2695 C LEU A 340 -8.170 8.421 -6.967 1.00 97.74 C \\\\nATOM 2696 CB LEU A 340 -6.636 9.839 -8.406 1.00 97.74 C \\\\nATOM 2697 O LEU A 340 -7.485 7.548 -6.431 1.00 97.74 O \\\\nATOM 2698 CG LEU A 340 -7.252 9.450 -9.765 1.00 97.74 C \\\\nATOM 2699 CD1 LEU A 340 -8.359 10.414 -10.195 1.00 97.74 C \\\\nATOM 2700 CD2 LEU A 340 -6.159 9.459 -10.835 1.00 97.74 C \\\\nATOM 2701 N LYS A 341 -9.407 8.188 -7.420 1.00 97.97 N \\\\nATOM 2702 CA LYS A 341 -10.010 6.849 -7.498 1.00 97.97 C \\\\nATOM 2703 C LYS A 341 -9.441 6.115 -8.710 1.00 97.97 C \\\\nATOM 2704 CB LYS A 341 -11.538 6.971 -7.566 1.00 97.97 C \\\\nATOM 2705 O LYS A 341 -9.873 6.340 -9.838 1.00 97.97 O \\\\nATOM 2706 CG LYS A 341 -12.210 5.588 -7.497 1.00 97.97 C \\\\nATOM 2707 CD LYS A 341 -13.726 5.666 -7.704 1.00 97.97 C \\\\nATOM 2708 CE LYS A 341 -14.397 6.548 -6.645 1.00 97.97 C \\\\nATOM 2709 NZ LYS A 341 -15.870 6.475 -6.744 1.00 97.97 N \\\\nATOM 2710 N ILE A 342 -8.457 5.254 -8.483 1.00 98.34 N \\\\nATOM 2711 CA ILE A 342 -7.732 4.562 -9.552 1.00 98.34 C \\\\nATOM 2712 C ILE A 342 -8.460 3.309 -10.050 1.00 98.34 C \\\\nATOM 2713 CB ILE A 342 -6.280 4.249 -9.132 1.00 98.34 C \\\\nATOM 2714 O ILE A 342 -8.189 2.889 -11.168 1.00 98.34 O \\\\nATOM 2715 CG1 ILE A 342 -6.231 3.224 -7.976 1.00 98.34 C \\\\nATOM 2716 CG2 ILE A 342 -5.535 5.553 -8.793 1.00 98.34 C \\\\nATOM 2717 CD1 ILE A 342 -4.827 2.765 -7.596 1.00 98.34 C \\\\nATOM 2718 N PHE A 343 -9.368 2.720 -9.264 1.00 98.38 N \\\\nATOM 2719 CA PHE A 343 -10.139 1.539 -9.668 1.00 98.38 C \\\\nATOM 2720 C PHE A 343 -11.522 1.488 -9.004 1.00 98.38 C \\\\nATOM 2721 CB PHE A 343 -9.354 0.262 -9.343 1.00 98.38 C \\\\nATOM 2722 O PHE A 343 -11.668 1.935 -7.865 1.00 98.38 O \\\\nATOM 2723 CG PHE A 343 -9.807 -0.946 -10.137 1.00 98.38 C \\\\nATOM 2724 CD1 PHE A 343 -10.721 -1.865 -9.586 1.00 98.38 C \\\\nATOM 2725 CD2 PHE A 343 -9.294 -1.165 -11.430 1.00 98.38 C \\\\nATOM 2726 CE1 PHE A 343 -11.108 -2.997 -10.323 1.00 98.38 C \\\\nATOM 2727 CE2 PHE A 343 -9.684 -2.301 -12.160 1.00 98.38 C \\\\nATOM 2728 CZ PHE A 343 -10.580 -3.224 -11.602 1.00 98.38 C \\\\nATOM 2729 N ASN A 344 -12.511 0.898 -9.675 1.00 96.95 N \\\\nATOM 2730 CA ASN A 344 -13.810 0.538 -9.101 1.00 96.95 C \\\\nATOM 2731 C ASN A 344 -14.249 -0.852 -9.617 1.00 96.95 C \\\\nATOM 2732 CB ASN A 344 -14.811 1.671 -9.406 1.00 96.95 C \\\\nATOM 2733 O ASN A 344 -14.299 -1.098 -10.824 1.00 96.95 O \\\\nATOM 2734 CG ASN A 344 -16.252 1.329 -9.067 1.00 96.95 C \\\\nATOM 2735 ND2 ASN A 344 -16.917 2.009 -8.169 1.00 96.95 N \\\\nATOM 2736 OD1 ASN A 344 -16.815 0.393 -9.597 1.00 96.95 O \\\\nATOM 2737 N ASN A 345 -14.585 -1.756 -8.691 1.00 95.65 N \\\\nATOM 2738 CA ASN A 345 -14.955 -3.140 -8.994 1.00 95.65 C \\\\nATOM 2739 C ASN A 345 -16.313 -3.279 -9.705 1.00 95.65 C \\\\nATOM 2740 CB ASN A 345 -14.978 -3.970 -7.695 1.00 95.65 C \\\\nATOM 2741 O ASN A 345 -16.496 -4.245 -10.438 1.00 95.65 O \\\\nATOM 2742 CG ASN A 345 -13.622 -4.311 -7.098 1.00 95.65 C \\\\nATOM 2743 ND2 ASN A 345 -13.616 -5.022 -5.996 1.00 95.65 N \\\\nATOM 2744 OD1 ASN A 345 -12.567 -3.976 -7.606 1.00 95.65 O \\\\nATOM 2745 N GLN A 346 -17.266 -2.360 -9.509 1.00 95.14 N \\\\nATOM 2746 CA GLN A 346 -18.570 -2.389 -10.192 1.00 95.14 C \\\\nATOM 2747 C GLN A 346 -18.434 -2.020 -11.675 1.00 95.14 C \\\\nATOM 2748 CB GLN A 346 -19.572 -1.432 -9.520 1.00 95.14 C \\\\nATOM 2749 O GLN A 346 -19.045 -2.656 -12.528 1.00 95.14 O \\\\nATOM 2750 CG GLN A 346 -19.850 -1.744 -8.045 1.00 95.14 C \\\\nATOM 2751 CD GLN A 346 -20.867 -0.771 -7.458 1.00 95.14 C \\\\nATOM 2752 NE2 GLN A 346 -21.978 -1.246 -6.939 1.00 95.14 N \\\\nATOM 2753 OE1 GLN A 346 -20.692 0.434 -7.453 1.00 95.14 O \\\\nATOM 2754 N GLU A 347 -17.593 -1.034 -11.990 1.00 95.97 N \\\\nATOM 2755 CA GLU A 347 -17.256 -0.657 -13.367 1.00 95.97 C \\\\nATOM 2756 C GLU A 347 -16.535 -1.805 -14.087 1.00 95.97 C \\\\nATOM 2757 CB GLU A 347 -16.368 0.596 -13.346 1.00 95.97 C \\\\nATOM 2758 O GLU A 347 -16.882 -2.144 -15.217 1.00 95.97 O \\\\nATOM 2759 CG GLU A 347 -17.108 1.858 -12.867 1.00 95.97 C \\\\nATOM 2760 CD GLU A 347 -16.146 3.008 -12.540 1.00 95.97 C \\\\nATOM 2761 OE1 GLU A 347 -16.567 4.018 -11.935 1.00 95.97 O \\\\nATOM 2762 OE2 GLU A 347 -14.927 2.898 -12.799 1.00 95.97 O \\\\nATOM 2763 N PHE A 348 -15.586 -2.464 -13.409 1.00 97.03 N \\\\nATOM 2764 CA PHE A 348 -14.939 -3.667 -13.936 1.00 97.03 C \\\\nATOM 2765 C PHE A 348 -15.919 -4.841 -14.102 1.00 97.03 C \\\\nATOM 2766 CB PHE A 348 -13.752 -4.044 -13.043 1.00 97.03 C \\\\nATOM 2767 O PHE A 348 -15.876 -5.515 -15.126 1.00 97.03 O \\\\nATOM 2768 CG PHE A 348 -13.012 -5.279 -13.524 1.00 97.03 C \\\\nATOM 2769 CD1 PHE A 348 -13.244 -6.527 -12.912 1.00 97.03 C \\\\nATOM 2770 CD2 PHE A 348 -12.127 -5.191 -14.616 1.00 97.03 C \\\\nATOM 2771 CE1 PHE A 348 -12.591 -7.679 -13.387 1.00 97.03 C \\\\nATOM 2772 CE2 PHE A 348 -11.474 -6.344 -15.089 1.00 97.03 C \\\\nATOM 2773 CZ PHE A 348 -11.706 -7.586 -14.474 1.00 97.03 C \\\\nATOM 2774 N ALA A 349 -16.836 -5.061 -13.151 1.00 95.38 N \\\\nATOM 2775 CA ALA A 349 -17.877 -6.089 -13.243 1.00 95.38 C \\\\nATOM 2776 C ALA A 349 -18.769 -5.904 -14.478 1.00 95.38 C \\\\nATOM 2777 CB ALA A 349 -18.758 -6.034 -11.985 1.00 95.38 C \\\\nATOM 2778 O ALA A 349 -19.033 -6.861 -15.205 1.00 95.38 O \\\\nATOM 2779 N ALA A 350 -19.224 -4.669 -14.713 1.00 95.44 N \\\\nATOM 2780 CA ALA A 350 -20.069 -4.329 -15.850 1.00 95.44 C \\\\nATOM 2781 C ALA A 350 -19.336 -4.555 -17.180 1.00 95.44 C \\\\nATOM 2782 CB ALA A 350 -20.535 -2.877 -15.689 1.00 95.44 C \\\\nATOM 2783 O ALA A 350 -19.901 -5.157 -18.091 1.00 95.44 O \\\\nATOM 2784 N LEU A 351 -18.068 -4.140 -17.268 1.00 95.45 N \\\\nATOM 2785 CA LEU A 351 -17.235 -4.369 -18.446 1.00 95.45 C \\\\nATOM 2786 C LEU A 351 -16.982 -5.863 -18.691 1.00 95.45 C \\\\nATOM 2787 CB LEU A 351 -15.927 -3.589 -18.264 1.00 95.45 C \\\\nATOM 2788 O LEU A 351 -17.164 -6.335 -19.808 1.00 95.45 O \\\\nATOM 2789 CG LEU A 351 -14.970 -3.702 -19.462 1.00 95.45 C \\\\nATOM 2790 CD1 LEU A 351 -15.584 -3.164 -20.755 1.00 95.45 C \\\\nATOM 2791 CD2 LEU A 351 -13.718 -2.901 -19.127 1.00 95.45 C \\\\nATOM 2792 N LEU A 352 -16.637 -6.626 -17.649 1.00 96.13 N \\\\nATOM 2793 CA LEU A 352 -16.427 -8.072 -17.739 1.00 96.13 C \\\\nATOM 2794 C LEU A 352 -17.687 -8.794 -18.240 1.00 96.13 C \\\\nATOM 2795 CB LEU A 352 -15.943 -8.577 -16.365 1.00 96.13 C \\\\nATOM 2796 O LEU A 352 -17.603 -9.603 -19.160 1.00 96.13 O \\\\nATOM 2797 CG LEU A 352 -15.683 -10.092 -16.272 1.00 96.13 C \\\\nATOM 2798 CD1 LEU A 352 -14.689 -10.587 -17.318 1.00 96.13 C \\\\nATOM 2799 CD2 LEU A 352 -15.118 -10.422 -14.887 1.00 96.13 C \\\\nATOM 2800 N ALA A 353 -18.862 -8.453 -17.703 1.00 94.39 N \\\\nATOM 2801 CA ALA A 353 -20.137 -9.006 -18.157 1.00 94.39 C \\\\nATOM 2802 C ALA A 353 -20.473 -8.643 -19.618 1.00 94.39 C \\\\nATOM 2803 CB ALA A 353 -21.234 -8.528 -17.198 1.00 94.39 C \\\\nATOM 2804 O ALA A 353 -21.095 -9.440 -20.318 1.00 94.39 O \\\\nATOM 2805 N GLN A 354 -20.057 -7.466 -20.099 1.00 94.04 N \\\\nATOM 2806 CA GLN A 354 -20.220 -7.067 -21.500 1.00 94.04 C \\\\nATOM 2807 C GLN A 354 -19.262 -7.839 -22.420 1.00 94.04 C \\\\nATOM 2808 CB GLN A 354 -20.038 -5.547 -21.636 1.00 94.04 C \\\\nATOM 2809 O GLN A 354 -19.718 -8.442 -23.394 1.00 94.04 O \\\\nATOM 2810 CG GLN A 354 -21.235 -4.775 -21.055 1.00 94.04 C \\\\nATOM 2811 CD GLN A 354 -20.982 -3.275 -20.915 1.00 94.04 C \\\\nATOM 2812 NE2 GLN A 354 -21.886 -2.546 -20.298 1.00 94.04 N \\\\nATOM 2813 OE1 GLN A 354 -19.994 -2.713 -21.353 1.00 94.04 O \\\\nATOM 2814 N SER A 355 -17.968 -7.887 -22.088 1.00 94.46 N \\\\nATOM 2815 CA SER A 355 -16.929 -8.520 -22.912 1.00 94.46 C \\\\nATOM 2816 C SER A 355 -17.077 -10.034 -23.059 1.00 94.46 C \\\\nATOM 2817 CB SER A 355 -15.537 -8.197 -22.368 1.00 94.46 C \\\\nATOM 2818 O SER A 355 -16.649 -10.571 -24.074 1.00 94.46 O \\\\nATOM 2819 OG SER A 355 -15.291 -6.809 -22.469 1.00 94.46 O \\\\nATOM 2820 N VAL A 356 -17.745 -10.732 -22.131 1.00 92.71 N \\\\nATOM 2821 CA VAL A 356 -18.093 -12.160 -22.307 1.00 92.71 C \\\\nATOM 2822 C VAL A 356 -18.860 -12.407 -23.613 1.00 92.71 C \\\\nATOM 2823 CB VAL A 356 -18.887 -12.669 -21.087 1.00 92.71 C \\\\nATOM 2824 O VAL A 356 -18.597 -13.386 -24.306 1.00 92.71 O \\\\nATOM 2825 CG1 VAL A 356 -19.590 -14.012 -21.311 1.00 92.71 C \\\\nATOM 2826 CG2 VAL A 356 -17.941 -12.871 -19.900 1.00 92.71 C \\\\nATOM 2827 N ASN A 357 -19.745 -11.487 -24.013 1.00 89.37 N \\\\nATOM 2828 CA ASN A 357 -20.513 -11.601 -25.261 1.00 89.37 C \\\\nATOM 2829 C ASN A 357 -19.690 -11.255 -26.519 1.00 89.37 C \\\\nATOM 2830 CB ASN A 357 -21.776 -10.732 -25.163 1.00 89.37 C \\\\nATOM 2831 O ASN A 357 -20.150 -11.488 -27.633 1.00 89.37 O \\\\nATOM 2832 CG ASN A 357 -22.604 -11.057 -23.936 1.00 89.37 C \\\\nATOM 2833 ND2 ASN A 357 -22.554 -10.217 -22.930 1.00 89.37 N \\\\nATOM 2834 OD1 ASN A 357 -23.262 -12.078 -23.847 1.00 89.37 O \\\\nATOM 2835 N GLN A 358 -18.487 -10.699 -26.346 1.00 91.08 N \\\\nATOM 2836 CA GLN A 358 -17.529 -10.374 -27.411 1.00 91.08 C \\\\nATOM 2837 C GLN A 358 -16.492 -11.499 -27.621 1.00 91.08 C \\\\nATOM 2838 CB GLN A 358 -16.841 -9.038 -27.074 1.00 91.08 C \\\\nATOM 2839 O GLN A 358 -15.707 -11.448 -28.566 1.00 91.08 O \\\\nATOM 2840 CG GLN A 358 -17.800 -7.840 -26.950 1.00 91.08 C \\\\nATOM 2841 CD GLN A 358 -17.139 -6.596 -26.353 1.00 91.08 C \\\\nATOM 2842 NE2 GLN A 358 -17.807 -5.465 -26.381 1.00 91.08 N \\\\nATOM 2843 OE1 GLN A 358 -16.049 -6.607 -25.801 1.00 91.08 O \\\\nATOM 2844 N GLY A 359 -16.494 -12.529 -26.765 1.00 90.37 N \\\\nATOM 2845 CA GLY A 359 -15.665 -13.728 -26.894 1.00 90.37 C \\\\nATOM 2846 C GLY A 359 -14.324 -13.684 -26.151 1.00 90.37 C \\\\nATOM 2847 O GLY A 359 -14.008 -12.750 -25.412 1.00 90.37 O \\\\nATOM 2848 N PHE A 360 -13.531 -14.747 -26.339 1.00 90.85 N \\\\nATOM 2849 CA PHE A 360 -12.313 -15.020 -25.561 1.00 90.85 C \\\\nATOM 2850 C PHE A 360 -11.310 -13.865 -25.550 1.00 90.85 C \\\\nATOM 2851 CB PHE A 360 -11.668 -16.329 -26.041 1.00 90.85 C \\\\nATOM 2852 O PHE A 360 -10.863 -13.465 -24.477 1.00 90.85 O \\\\nATOM 2853 CG PHE A 360 -10.561 -16.809 -25.121 1.00 90.85 C \\\\nATOM 2854 CD1 PHE A 360 -9.265 -16.267 -25.227 1.00 90.85 C \\\\nATOM 2855 CD2 PHE A 360 -10.837 -17.763 -24.121 1.00 90.85 C \\\\nATOM 2856 CE1 PHE A 360 -8.253 -16.670 -24.338 1.00 90.85 C \\\\nATOM 2857 CE2 PHE A 360 -9.824 -18.168 -23.234 1.00 90.85 C \\\\nATOM 2858 CZ PHE A 360 -8.532 -17.623 -23.343 1.00 90.85 C \\\\nATOM 2859 N GLU A 361 -10.982 -13.310 -26.717 1.00 91.71 N \\\\nATOM 2860 CA GLU A 361 -9.951 -12.274 -26.825 1.00 91.71 C \\\\nATOM 2861 C GLU A 361 -10.351 -10.987 -26.091 1.00 91.71 C \\\\nATOM 2862 CB GLU A 361 -9.656 -12.018 -28.313 1.00 91.71 C \\\\nATOM 2863 O GLU A 361 -9.552 -10.427 -25.345 1.00 91.71 O \\\\nATOM 2864 CG GLU A 361 -8.429 -11.123 -28.545 1.00 91.71 C \\\\nATOM 2865 CD GLU A 361 -7.154 -11.667 -27.883 1.00 91.71 C \\\\nATOM 2866 OE1 GLU A 361 -6.342 -10.831 -27.422 1.00 91.71 O \\\\nATOM 2867 OE2 GLU A 361 -7.010 -12.908 -27.800 1.00 91.71 O \\\\nATOM 2868 N ALA A 362 -11.613 -10.562 -26.213 1.00 93.21 N \\\\nATOM 2869 CA ALA A 362 -12.117 -9.369 -25.538 1.00 93.21 C \\\\nATOM 2870 C ALA A 362 -11.999 -9.481 -24.010 1.00 93.21 C \\\\nATOM 2871 CB ALA A 362 -13.566 -9.150 -25.973 1.00 93.21 C \\\\nATOM 2872 O ALA A 362 -11.527 -8.553 -23.355 1.00 93.21 O \\\\nATOM 2873 N VAL A 363 -12.357 -10.639 -23.441 1.00 93.93 N \\\\nATOM 2874 CA VAL A 363 -12.168 -10.907 -22.007 1.00 93.93 C \\\\nATOM 2875 C VAL A 363 -10.682 -11.016 -21.660 1.00 93.93 C \\\\nATOM 2876 CB VAL A 363 -12.953 -12.156 -21.569 1.00 93.93 C \\\\nATOM 2877 O VAL A 363 -10.252 -10.433 -20.670 1.00 93.93 O \\\\nATOM 2878 CG1 VAL A 363 -12.751 -12.502 -20.091 1.00 93.93 C \\\\nATOM 2879 CG2 VAL A 363 -14.456 -11.915 -21.749 1.00 93.93 C \\\\nATOM 2880 N TYR A 364 -9.862 -11.685 -22.472 1.00 93.20 N \\\\nATOM 2881 CA TYR A 364 -8.427 -11.825 -22.207 1.00 93.20 C \\\\nATOM 2882 C TYR A 364 -7.715 -10.462 -22.122 1.00 93.20 C \\\\nATOM 2883 CB TYR A 364 -7.800 -12.732 -23.272 1.00 93.20 C \\\\nATOM 2884 O TYR A 364 -6.920 -10.228 -21.204 1.00 93.20 O \\\\nATOM 2885 CG TYR A 364 -6.345 -13.042 -22.995 1.00 93.20 C \\\\nATOM 2886 CD1 TYR A 364 -5.330 -12.355 -23.688 1.00 93.20 C \\\\nATOM 2887 CD2 TYR A 364 -6.013 -13.994 -22.012 1.00 93.20 C \\\\nATOM 2888 CE1 TYR A 364 -3.979 -12.605 -23.380 1.00 93.20 C \\\\nATOM 2889 CE2 TYR A 364 -4.663 -14.253 -21.707 1.00 93.20 C \\\\nATOM 2890 OH TYR A 364 -2.341 -13.787 -22.088 1.00 93.20 O \\\\nATOM 2891 CZ TYR A 364 -3.645 -13.550 -22.388 1.00 93.20 C \\\\nATOM 2892 N GLN A 365 -8.072 -9.512 -22.994 1.00 93.42 N \\\\nATOM 2893 CA GLN A 365 -7.553 -8.140 -22.965 1.00 93.42 C \\\\nATOM 2894 C GLN A 365 -7.907 -7.379 -21.672 1.00 93.42 C \\\\nATOM 2895 CB GLN A 365 -8.040 -7.370 -24.206 1.00 93.42 C \\\\nATOM 2896 O GLN A 365 -7.131 -6.515 -21.249 1.00 93.42 O \\\\nATOM 2897 CG GLN A 365 -7.428 -7.884 -25.524 1.00 93.42 C \\\\nATOM 2898 CD GLN A 365 -5.914 -7.725 -25.629 1.00 93.42 C \\\\nATOM 2899 NE2 GLN A 365 -5.257 -8.548 -26.410 1.00 93.42 N \\\\nATOM 2900 OE1 GLN A 365 -5.283 -6.872 -25.015 1.00 93.42 O \\\\nATOM 2901 N LEU A 366 -8.993 -7.738 -20.967 1.00 95.17 N \\\\nATOM 2902 CA LEU A 366 -9.334 -7.145 -19.664 1.00 95.17 C \\\\nATOM 2903 C LEU A 366 -8.290 -7.423 -18.574 1.00 95.17 C \\\\nATOM 2904 CB LEU A 366 -10.722 -7.583 -19.165 1.00 95.17 C \\\\nATOM 2905 O LEU A 366 -8.277 -6.712 -17.570 1.00 95.17 O \\\\nATOM 2906 CG LEU A 366 -11.909 -7.249 -20.080 1.00 95.17 C \\\\nATOM 2907 CD1 LEU A 366 -13.200 -7.665 -19.379 1.00 95.17 C \\\\nATOM 2908 CD2 LEU A 366 -11.996 -5.757 -20.398 1.00 95.17 C \\\\nATOM 2909 N THR A 367 -7.352 -8.355 -18.783 1.00 95.31 N \\\\nATOM 2910 CA THR A 367 -6.177 -8.527 -17.907 1.00 95.31 C \\\\nATOM 2911 C THR A 367 -5.436 -7.198 -17.716 1.00 95.31 C \\\\nATOM 2912 CB THR A 367 -5.206 -9.573 -18.482 1.00 95.31 C \\\\nATOM 2913 O THR A 367 -5.001 -6.880 -16.610 1.00 95.31 O \\\\nATOM 2914 CG2 THR A 367 -4.080 -9.922 -17.507 1.00 95.31 C \\\\nATOM 2915 OG1 THR A 367 -5.878 -10.777 -18.753 1.00 95.31 O \\\\nATOM 2916 N ARG A 368 -5.376 -6.362 -18.767 1.00 94.06 N \\\\nATOM 2917 CA ARG A 368 -4.761 -5.024 -18.728 1.00 94.06 C \\\\nATOM 2918 C ARG A 368 -5.491 -4.059 -17.790 1.00 94.06 C \\\\nATOM 2919 CB ARG A 368 -4.712 -4.429 -20.146 1.00 94.06 C \\\\nATOM 2920 O ARG A 368 -4.845 -3.193 -17.211 1.00 94.06 O \\\\nATOM 2921 CG ARG A 368 -3.878 -5.258 -21.138 1.00 94.06 C \\\\nATOM 2922 CD ARG A 368 -3.914 -4.608 -22.527 1.00 94.06 C \\\\nATOM 2923 NE ARG A 368 -3.118 -5.365 -23.510 1.00 94.06 N \\\\nATOM 2924 NH1 ARG A 368 -3.408 -3.937 -25.296 1.00 94.06 N \\\\nATOM 2925 NH2 ARG A 368 -2.269 -5.831 -25.575 1.00 94.06 N \\\\nATOM 2926 CZ ARG A 368 -2.938 -5.042 -24.782 1.00 94.06 C \\\\nATOM 2927 N MET A 369 -6.806 -4.208 -17.603 1.00 95.92 N \\\\nATOM 2928 CA MET A 369 -7.591 -3.369 -16.685 1.00 95.92 C \\\\nATOM 2929 C MET A 369 -7.190 -3.597 -15.226 1.00 95.92 C \\\\nATOM 2930 CB MET A 369 -9.098 -3.637 -16.840 1.00 95.92 C \\\\nATOM 2931 O MET A 369 -7.254 -2.670 -14.421 1.00 95.92 O \\\\nATOM 2932 CG MET A 369 -9.631 -3.405 -18.258 1.00 95.92 C \\\\nATOM 2933 SD MET A 369 -9.534 -1.698 -18.853 1.00 95.92 S \\\\nATOM 2934 CE MET A 369 -10.858 -0.933 -17.889 1.00 95.92 C \\\\nATOM 2935 N CYS A 370 -6.756 -4.814 -14.892 1.00 97.33 N \\\\nATOM 2936 CA CYS A 370 -6.361 -5.210 -13.542 1.00 97.33 C \\\\nATOM 2937 C CYS A 370 -4.930 -4.783 -13.163 1.00 97.33 C \\\\nATOM 2938 CB CYS A 370 -6.520 -6.726 -13.419 1.00 97.33 C \\\\nATOM 2939 O CYS A 370 -4.534 -4.961 -12.006 1.00 97.33 O \\\\nATOM 2940 SG CYS A 370 -8.188 -7.266 -13.897 1.00 97.33 S \\\\nATOM 2941 N THR A 371 -4.166 -4.227 -14.112 1.00 97.75 N \\\\nATOM 2942 CA THR A 371 -2.799 -3.731 -13.912 1.00 97.75 C \\\\nATOM 2943 C THR A 371 -2.781 -2.203 -13.909 1.00 97.75 C \\\\nATOM 2944 CB THR A 371 -1.831 -4.295 -14.965 1.00 97.75 C \\\\nATOM 2945 O THR A 371 -3.195 -1.556 -14.869 1.00 97.75 O \\\\nATOM 2946 CG2 THR A 371 -0.398 -3.796 -14.784 1.00 97.75 C \\\\nATOM 2947 OG1 THR A 371 -1.781 -5.699 -14.867 1.00 97.75 O \\\\nATOM 2948 N ILE A 372 -2.257 -1.608 -12.836 1.00 98.54 N \\\\nATOM 2949 CA ILE A 372 -2.121 -0.152 -12.686 1.00 98.54 C \\\\nATOM 2950 C ILE A 372 -0.647 0.191 -12.503 1.00 98.54 C \\\\nATOM 2951 CB ILE A 372 -2.996 0.374 -11.525 1.00 98.54 C \\\\nATOM 2952 O ILE A 372 0.026 -0.382 -11.648 1.00 98.54 O \\\\nATOM 2953 CG1 ILE A 372 -4.488 0.075 -11.799 1.00 98.54 C \\\\nATOM 2954 CG2 ILE A 372 -2.745 1.881 -11.307 1.00 98.54 C \\\\nATOM 2955 CD1 ILE A 372 -5.428 0.435 -10.644 1.00 98.54 C \\\\nATOM 2956 N ARG A 373 -0.136 1.158 -13.267 1.00 98.65 N \\\\nATOM 2957 CA ARG A 373 1.268 1.590 -13.178 1.00 98.65 C \\\\nATOM 2958 C ARG A 373 1.374 2.972 -12.567 1.00 98.65 C \\\\nATOM 2959 CB ARG A 373 1.950 1.501 -14.547 1.00 98.65 C \\\\nATOM 2960 O ARG A 373 0.597 3.860 -12.919 1.00 98.65 O \\\\nATOM 2961 CG ARG A 373 1.956 0.049 -15.037 1.00 98.65 C \\\\nATOM 2962 CD ARG A 373 2.780 -0.093 -16.310 1.00 98.65 C \\\\nATOM 2963 NE ARG A 373 2.808 -1.498 -16.728 1.00 98.65 N \\\\nATOM 2964 NH1 ARG A 373 1.773 -1.380 -18.785 1.00 98.65 N \\\\nATOM 2965 NH2 ARG A 373 2.486 -3.339 -17.937 1.00 98.65 N \\\\nATOM 2966 CZ ARG A 373 2.352 -2.053 -17.828 1.00 98.65 C \\\\nATOM 2967 N MET A 374 2.340 3.170 -11.670 1.00 98.70 N \\\\nATOM 2968 CA MET A 374 2.595 4.475 -11.055 1.00 98.70 C \\\\nATOM 2969 C MET A 374 4.073 4.844 -11.050 1.00 98.70 C \\\\nATOM 2970 CB MET A 374 2.054 4.573 -9.625 1.00 98.70 C \\\\nATOM 2971 O MET A 374 4.883 4.113 -10.489 1.00 98.70 O \\\\nATOM 2972 CG MET A 374 0.607 4.118 -9.491 1.00 98.70 C \\\\nATOM 2973 SD MET A 374 -0.088 4.536 -7.879 1.00 98.70 S \\\\nATOM 2974 CE MET A 374 -1.719 3.823 -8.145 1.00 98.70 C \\\\nATOM 2975 N SER A 375 4.416 6.010 -11.595 1.00 98.78 N \\\\nATOM 2976 CA SER A 375 5.757 6.597 -11.498 1.00 98.78 C \\\\nATOM 2977 C SER A 375 5.819 7.646 -10.391 1.00 98.78 C \\\\nATOM 2978 CB SER A 375 6.193 7.202 -12.831 1.00 98.78 C \\\\nATOM 2979 O SER A 375 4.895 8.447 -10.214 1.00 98.78 O \\\\nATOM 2980 OG SER A 375 7.441 7.846 -12.697 1.00 98.78 O \\\\nATOM 2981 N PHE A 376 6.942 7.680 -9.677 1.00 98.81 N \\\\nATOM 2982 CA PHE A 376 7.247 8.703 -8.685 1.00 98.81 C \\\\nATOM 2983 C PHE A 376 8.044 9.849 -9.319 1.00 98.81 C \\\\nATOM 2984 CB PHE A 376 8.019 8.080 -7.515 1.00 98.81 C \\\\nATOM 2985 O PHE A 376 9.028 9.620 -10.023 1.00 98.81 O \\\\nATOM 2986 CG PHE A 376 7.275 6.993 -6.762 1.00 98.81 C \\\\nATOM 2987 CD1 PHE A 376 6.403 7.336 -5.711 1.00 98.81 C \\\\nATOM 2988 CD2 PHE A 376 7.459 5.639 -7.102 1.00 98.81 C \\\\nATOM 2989 CE1 PHE A 376 5.723 6.330 -5.001 1.00 98.81 C \\\\nATOM 2990 CE2 PHE A 376 6.777 4.635 -6.393 1.00 98.81 C \\\\nATOM 2991 CZ PHE A 376 5.910 4.979 -5.342 1.00 98.81 C \\\\nATOM 2992 N VAL A 377 7.682 11.099 -9.004 1.00 98.56 N \\\\nATOM 2993 CA VAL A 377 8.406 12.346 -9.346 1.00 98.56 C \\\\nATOM 2994 C VAL A 377 8.447 12.701 -10.843 1.00 98.56 C \\\\nATOM 2995 CB VAL A 377 9.846 12.335 -8.774 1.00 98.56 C \\\\nATOM 2996 O VAL A 377 8.438 13.885 -11.182 1.00 98.56 O \\\\nATOM 2997 CG1 VAL A 377 10.498 13.724 -8.771 1.00 98.56 C \\\\nATOM 2998 CG2 VAL A 377 9.970 11.778 -7.346 1.00 98.56 C \\\\nATOM 2999 N LYS A 378 8.509 11.725 -11.758 1.00 98.24 N \\\\nATOM 3000 CA LYS A 378 8.670 11.928 -13.209 1.00 98.24 C \\\\nATOM 3001 C LYS A 378 7.483 11.353 -13.989 1.00 98.24 C \\\\nATOM 3002 CB LYS A 378 9.996 11.299 -13.693 1.00 98.24 C \\\\nATOM 3003 O LYS A 378 7.233 10.155 -13.919 1.00 98.24 O \\\\nATOM 3004 CG LYS A 378 11.266 11.754 -12.948 1.00 98.24 C \\\\nATOM 3005 CD LYS A 378 11.501 13.272 -12.973 1.00 98.24 C \\\\nATOM 3006 CE LYS A 378 12.773 13.608 -12.185 1.00 98.24 C \\\\nATOM 3007 NZ LYS A 378 12.933 15.073 -12.002 1.00 98.24 N \\\\nATOM 3008 N GLY A 379 6.803 12.192 -14.767 1.00 97.29 N \\\\nATOM 3009 CA GLY A 379 5.748 11.760 -15.689 1.00 97.29 C \\\\nATOM 3010 C GLY A 379 6.277 11.053 -16.939 1.00 97.29 C \\\\nATOM 3011 O GLY A 379 7.464 11.159 -17.273 1.00 97.29 O \\\\nATOM 3012 N TRP A 380 5.368 10.348 -17.612 1.00 98.27 N \\\\nATOM 3013 CA TRP A 380 5.543 9.736 -18.930 1.00 98.27 C \\\\nATOM 3014 C TRP A 380 4.223 9.790 -19.721 1.00 98.27 C \\\\nATOM 3015 CB TRP A 380 6.049 8.290 -18.793 1.00 98.27 C \\\\nATOM 3016 O TRP A 380 3.188 10.128 -19.148 1.00 98.27 O \\\\nATOM 3017 CG TRP A 380 5.001 7.249 -18.540 1.00 98.27 C \\\\nATOM 3018 CD1 TRP A 380 4.437 6.468 -19.491 1.00 98.27 C \\\\nATOM 3019 CD2 TRP A 380 4.327 6.901 -17.293 1.00 98.27 C \\\\nATOM 3020 CE2 TRP A 380 3.395 5.855 -17.564 1.00 98.27 C \\\\nATOM 3021 CE3 TRP A 380 4.395 7.369 -15.962 1.00 98.27 C \\\\nATOM 3022 NE1 TRP A 380 3.495 5.638 -18.919 1.00 98.27 N \\\\nATOM 3023 CH2 TRP A 380 2.678 5.771 -15.259 1.00 98.27 C \\\\nATOM 3024 CZ2 TRP A 380 2.605 5.271 -16.567 1.00 98.27 C \\\\nATOM 3025 CZ3 TRP A 380 3.563 6.822 -14.967 1.00 98.27 C \\\\nATOM 3026 N GLY A 381 4.259 9.453 -21.010 1.00 95.83 N \\\\nATOM 3027 CA GLY A 381 3.134 9.560 -21.944 1.00 95.83 C \\\\nATOM 3028 C GLY A 381 3.169 10.863 -22.749 1.00 95.83 C \\\\nATOM 3029 O GLY A 381 4.135 11.616 -22.647 1.00 95.83 O \\\\nATOM 3030 N ALA A 382 2.109 11.126 -23.522 1.00 92.96 N \\\\nATOM 3031 CA ALA A 382 2.044 12.198 -24.528 1.00 92.96 C \\\\nATOM 3032 C ALA A 382 2.542 13.575 -24.035 1.00 92.96 C \\\\nATOM 3033 CB ALA A 382 0.592 12.282 -25.020 1.00 92.96 C \\\\nATOM 3034 O ALA A 382 3.350 14.214 -24.702 1.00 92.96 O \\\\nATOM 3035 N GLU A 383 2.152 13.976 -22.821 1.00 91.46 N \\\\nATOM 3036 CA GLU A 383 2.499 15.270 -22.206 1.00 91.46 C \\\\nATOM 3037 C GLU A 383 3.948 15.372 -21.678 1.00 91.46 C \\\\nATOM 3038 CB GLU A 383 1.507 15.559 -21.063 1.00 91.46 C \\\\nATOM 3039 O GLU A 383 4.318 16.347 -21.019 1.00 91.46 O \\\\nATOM 3040 CG GLU A 383 0.031 15.522 -21.482 1.00 91.46 C \\\\nATOM 3041 CD GLU A 383 -0.228 16.402 -22.707 1.00 91.46 C \\\\nATOM 3042 OE1 GLU A 383 -0.810 15.863 -23.671 1.00 91.46 O \\\\nATOM 3043 OE2 GLU A 383 0.203 17.575 -22.659 1.00 91.46 O \\\\nATOM 3044 N TYR A 384 4.787 14.351 -21.888 1.00 95.61 N \\\\nATOM 3045 CA TYR A 384 6.121 14.262 -21.297 1.00 95.61 C \\\\nATOM 3046 C TYR A 384 7.166 13.757 -22.295 1.00 95.61 C \\\\nATOM 3047 CB TYR A 384 6.084 13.357 -20.051 1.00 95.61 C \\\\nATOM 3048 O TYR A 384 6.925 12.880 -23.113 1.00 95.61 O \\\\nATOM 3049 CG TYR A 384 5.120 13.811 -18.968 1.00 95.61 C \\\\nATOM 3050 CD1 TYR A 384 5.477 14.837 -18.069 1.00 95.61 C \\\\nATOM 3051 CD2 TYR A 384 3.824 13.267 -18.924 1.00 95.61 C \\\\nATOM 3052 CE1 TYR A 384 4.523 15.344 -17.162 1.00 95.61 C \\\\nATOM 3053 CE2 TYR A 384 2.872 13.758 -18.015 1.00 95.61 C \\\\nATOM 3054 OH TYR A 384 2.248 15.383 -16.376 1.00 95.61 O \\\\nATOM 3055 CZ TYR A 384 3.208 14.827 -17.161 1.00 95.61 C \\\\nATOM 3056 N ARG A 385 8.418 14.209 -22.132 1.00 95.60 N \\\\nATOM 3057 CA ARG A 385 9.572 13.721 -22.919 1.00 95.60 C \\\\nATOM 3058 C ARG A 385 9.787 12.195 -22.835 1.00 95.60 C \\\\nATOM 3059 CB ARG A 385 10.822 14.516 -22.492 1.00 95.60 C \\\\nATOM 3060 O ARG A 385 10.451 11.618 -23.689 1.00 95.60 O \\\\nATOM 3061 CG ARG A 385 12.085 14.098 -23.262 1.00 95.60 C \\\\nATOM 3062 CD ARG A 385 13.284 15.003 -22.977 1.00 95.60 C \\\\nATOM 3063 NE ARG A 385 14.513 14.388 -23.516 1.00 95.60 N \\\\nATOM 3064 NH1 ARG A 385 15.973 15.009 -21.858 1.00 95.60 N \\\\nATOM 3065 NH2 ARG A 385 16.623 13.531 -23.347 1.00 95.60 N \\\\nATOM 3066 CZ ARG A 385 15.687 14.316 -22.919 1.00 95.60 C \\\\nATOM 3067 N ARG A 386 9.276 11.538 -21.790 1.00 96.56 N \\\\nATOM 3068 CA ARG A 386 9.328 10.080 -21.615 1.00 96.56 C \\\\nATOM 3069 C ARG A 386 8.064 9.473 -22.206 1.00 96.56 C \\\\nATOM 3070 CB ARG A 386 9.416 9.737 -20.120 1.00 96.56 C \\\\nATOM 3071 O ARG A 386 7.011 9.641 -21.612 1.00 96.56 O \\\\nATOM 3072 CG ARG A 386 10.779 10.093 -19.533 1.00 96.56 C \\\\nATOM 3073 CD ARG A 386 10.772 9.857 -18.020 1.00 96.56 C \\\\nATOM 3074 NE ARG A 386 12.126 10.031 -17.471 1.00 96.56 N \\\\nATOM 3075 NH1 ARG A 386 12.152 12.322 -17.440 1.00 96.56 N \\\\nATOM 3076 NH2 ARG A 386 14.040 11.183 -17.055 1.00 96.56 N \\\\nATOM 3077 CZ ARG A 386 12.764 11.175 -17.316 1.00 96.56 C \\\\nATOM 3078 N GLN A 387 8.162 8.731 -23.303 1.00 96.27 N \\\\nATOM 3079 CA GLN A 387 6.978 8.072 -23.868 1.00 96.27 C \\\\nATOM 3080 C GLN A 387 6.599 6.798 -23.101 1.00 96.27 C \\\\nATOM 3081 CB GLN A 387 7.175 7.829 -25.375 1.00 96.27 C \\\\nATOM 3082 O GLN A 387 5.418 6.542 -22.877 1.00 96.27 O \\\\nATOM 3083 CG GLN A 387 7.368 9.140 -26.168 1.00 96.27 C \\\\nATOM 3084 CD GLN A 387 6.268 10.168 -25.894 1.00 96.27 C \\\\nATOM 3085 NE2 GLN A 387 6.591 11.439 -25.828 1.00 96.27 N \\\\nATOM 3086 OE1 GLN A 387 5.116 9.840 -25.663 1.00 96.27 O \\\\nATOM 3087 N THR A 388 7.585 6.039 -22.609 1.00 96.77 N \\\\nATOM 3088 CA THR A 388 7.359 4.769 -21.901 1.00 96.77 C \\\\nATOM 3089 C THR A 388 7.482 4.891 -20.379 1.00 96.77 C \\\\nATOM 3090 CB THR A 388 8.262 3.641 -22.424 1.00 96.77 C \\\\nATOM 3091 O THR A 388 8.281 5.683 -19.868 1.00 96.77 O \\\\nATOM 3092 CG2 THR A 388 8.328 3.568 -23.951 1.00 96.77 C \\\\nATOM 3093 OG1 THR A 388 9.576 3.812 -21.939 1.00 96.77 O \\\\nATOM 3094 N VAL A 389 6.756 4.048 -19.633 1.00 97.45 N \\\\nATOM 3095 CA VAL A 389 6.912 3.957 -18.167 1.00 97.45 C \\\\nATOM 3096 C VAL A 389 8.310 3.454 -17.785 1.00 97.45 C \\\\nATOM 3097 CB VAL A 389 5.801 3.086 -17.550 1.00 97.45 C \\\\nATOM 3098 O VAL A 389 8.912 3.944 -16.831 1.00 97.45 O \\\\nATOM 3099 CG1 VAL A 389 5.955 1.595 -17.873 1.00 97.45 C \\\\nATOM 3100 CG2 VAL A 389 5.724 3.294 -16.035 1.00 97.45 C \\\\nATOM 3101 N THR A 390 8.887 2.575 -18.610 1.00 97.99 N \\\\nATOM 3102 CA THR A 390 10.258 2.053 -18.489 1.00 97.99 C \\\\nATOM 3103 C THR A 390 11.346 3.119 -18.676 1.00 97.99 C \\\\nATOM 3104 CB THR A 390 10.484 0.908 -19.489 1.00 97.99 C \\\\nATOM 3105 O THR A 390 12.499 2.887 -18.328 1.00 97.99 O \\\\nATOM 3106 CG2 THR A 390 9.628 -0.312 -19.156 1.00 97.99 C \\\\nATOM 3107 OG1 THR A 390 10.131 1.299 -20.801 1.00 97.99 O \\\\nATOM 3108 N SER A 391 10.993 4.315 -19.163 1.00 97.57 N \\\\nATOM 3109 CA SER A 391 11.880 5.488 -19.190 1.00 97.57 C \\\\nATOM 3110 C SER A 391 11.865 6.287 -17.876 1.00 97.57 C \\\\nATOM 3111 CB SER A 391 11.491 6.413 -20.347 1.00 97.57 C \\\\nATOM 3112 O SER A 391 12.628 7.250 -17.716 1.00 97.57 O \\\\nATOM 3113 OG SER A 391 11.570 5.771 -21.600 1.00 97.57 O \\\\nATOM 3114 N THR A 392 10.972 5.959 -16.936 1.00 98.21 N \\\\nATOM 3115 CA THR A 392 10.876 6.643 -15.639 1.00 98.21 C \\\\nATOM 3116 C THR A 392 11.872 6.052 -14.631 1.00 98.21 C \\\\nATOM 3117 CB THR A 392 9.458 6.672 -15.051 1.00 98.21 C \\\\nATOM 3118 O THR A 392 12.089 4.840 -14.616 1.00 98.21 O \\\\nATOM 3119 CG2 THR A 392 8.388 7.194 -16.015 1.00 98.21 C \\\\nATOM 3120 OG1 THR A 392 9.084 5.412 -14.573 1.00 98.21 O \\\\nATOM 3121 N PRO A 393 12.518 6.866 -13.771 1.00 98.48 N \\\\nATOM 3122 CA PRO A 393 13.592 6.349 -12.921 1.00 98.48 C \\\\nATOM 3123 C PRO A 393 13.100 5.443 -11.783 1.00 98.48 C \\\\nATOM 3124 CB PRO A 393 14.326 7.582 -12.381 1.00 98.48 C \\\\nATOM 3125 O PRO A 393 13.865 4.617 -11.299 1.00 98.48 O \\\\nATOM 3126 CG PRO A 393 13.897 8.717 -13.306 1.00 98.48 C \\\\nATOM 3127 CD PRO A 393 12.477 8.318 -13.683 1.00 98.48 C \\\\nATOM 3128 N CYS A 394 11.856 5.613 -11.327 1.00 98.74 N \\\\nATOM 3129 CA CYS A 394 11.266 4.879 -10.207 1.00 98.74 C \\\\nATOM 3130 C CYS A 394 9.761 4.723 -10.431 1.00 98.74 C \\\\nATOM 3131 CB CYS A 394 11.484 5.670 -8.905 1.00 98.74 C \\\\nATOM 3132 O CYS A 394 9.036 5.719 -10.370 1.00 98.74 O \\\\nATOM 3133 SG CYS A 394 13.241 5.820 -8.497 1.00 98.74 S \\\\nATOM 3134 N TRP A 395 9.288 3.495 -10.619 1.00 98.82 N \\\\nATOM 3135 CA TRP A 395 7.864 3.208 -10.776 1.00 98.82 C \\\\nATOM 3136 C TRP A 395 7.477 1.861 -10.162 1.00 98.82 C \\\\nATOM 3137 CB TRP A 395 7.465 3.314 -12.257 1.00 98.82 C \\\\nATOM 3138 O TRP A 395 8.329 1.046 -9.813 1.00 98.82 O \\\\nATOM 3139 CG TRP A 395 8.092 2.330 -13.189 1.00 98.82 C \\\\nATOM 3140 CD1 TRP A 395 9.343 2.411 -13.690 1.00 98.82 C \\\\nATOM 3141 CD2 TRP A 395 7.504 1.123 -13.769 1.00 98.82 C \\\\nATOM 3142 CE2 TRP A 395 8.473 0.520 -14.624 1.00 98.82 C \\\\nATOM 3143 CE3 TRP A 395 6.250 0.480 -13.671 1.00 98.82 C \\\\nATOM 3144 NE1 TRP A 395 9.567 1.348 -14.535 1.00 98.82 N \\\\nATOM 3145 CH2 TRP A 395 6.985 -1.301 -15.179 1.00 98.82 C \\\\nATOM 3146 CZ2 TRP A 395 8.237 -0.677 -15.311 1.00 98.82 C \\\\nATOM 3147 CZ3 TRP A 395 5.993 -0.713 -14.374 1.00 98.82 C \\\\nATOM 3148 N ILE A 396 6.178 1.660 -9.978 1.00 98.81 N \\\\nATOM 3149 CA ILE A 396 5.573 0.439 -9.447 1.00 98.81 C \\\\nATOM 3150 C ILE A 396 4.464 -0.057 -10.370 1.00 98.81 C \\\\nATOM 3151 CB ILE A 396 5.055 0.618 -7.998 1.00 98.81 C \\\\nATOM 3152 O ILE A 396 3.745 0.736 -10.983 1.00 98.81 O \\\\nATOM 3153 CG1 ILE A 396 4.207 1.900 -7.835 1.00 98.81 C \\\\nATOM 3154 CG2 ILE A 396 6.250 0.602 -7.030 1.00 98.81 C \\\\nATOM 3155 CD1 ILE A 396 3.470 2.058 -6.498 1.00 98.81 C \\\\nATOM 3156 N GLU A 397 4.315 -1.374 -10.421 1.00 98.72 N \\\\nATOM 3157 CA GLU A 397 3.209 -2.078 -11.062 1.00 98.72 C \\\\nATOM 3158 C GLU A 397 2.344 -2.726 -9.976 1.00 98.72 C \\\\nATOM 3159 CB GLU A 397 3.781 -3.100 -12.056 1.00 98.72 C \\\\nATOM 3160 O GLU A 397 2.847 -3.509 -9.169 1.00 98.72 O \\\\nATOM 3161 CG GLU A 397 2.709 -3.684 -12.983 1.00 98.72 C \\\\nATOM 3162 CD GLU A 397 3.354 -4.370 -14.196 1.00 98.72 C \\\\nATOM 3163 OE1 GLU A 397 4.027 -5.404 -14.009 1.00 98.72 O \\\\nATOM 3164 OE2 GLU A 397 3.229 -3.803 -15.313 1.00 98.72 O \\\\nATOM 3165 N LEU A 398 1.064 -2.356 -9.931 1.00 98.36 N \\\\nATOM 3166 CA LEU A 398 0.030 -2.936 -9.076 1.00 98.36 C \\\\nATOM 3167 C LEU A 398 -0.766 -3.952 -9.890 1.00 98.36 C \\\\nATOM 3168 CB LEU A 398 -0.960 -1.852 -8.600 1.00 98.36 C \\\\nATOM 3169 O LEU A 398 -1.309 -3.596 -10.934 1.00 98.36 O \\\\nATOM 3170 CG LEU A 398 -0.604 -1.058 -7.342 1.00 98.36 C \\\\nATOM 3171 CD1 LEU A 398 0.694 -0.268 -7.468 1.00 98.36 C \\\\nATOM 3172 CD2 LEU A 398 -1.738 -0.065 -7.071 1.00 98.36 C \\\\nATOM 3173 N HIS A 399 -0.933 -5.157 -9.358 1.00 98.32 N \\\\nATOM 3174 CA HIS A 399 -1.912 -6.134 -9.832 1.00 98.32 C \\\\nATOM 3175 C HIS A 399 -3.045 -6.261 -8.817 1.00 98.32 C \\\\nATOM 3176 CB HIS A 399 -1.212 -7.476 -10.077 1.00 98.32 C \\\\nATOM 3177 O HIS A 399 -2.795 -6.535 -7.642 1.00 98.32 O \\\\nATOM 3178 CG HIS A 399 -0.309 -7.495 -11.284 1.00 98.32 C \\\\nATOM 3179 CD2 HIS A 399 -0.246 -6.557 -12.278 1.00 98.32 C \\\\nATOM 3180 ND1 HIS A 399 0.574 -8.494 -11.622 1.00 98.32 N \\\\nATOM 3181 CE1 HIS A 399 1.150 -8.160 -12.792 1.00 98.32 C \\\\nATOM 3182 NE2 HIS A 399 0.669 -6.989 -13.236 1.00 98.32 N \\\\nATOM 3183 N LEU A 400 -4.286 -6.050 -9.260 1.00 98.07 N \\\\nATOM 3184 CA LEU A 400 -5.481 -6.181 -8.426 1.00 98.07 C \\\\nATOM 3185 C LEU A 400 -5.967 -7.633 -8.445 1.00 98.07 C \\\\nATOM 3186 CB LEU A 400 -6.556 -5.184 -8.888 1.00 98.07 C \\\\nATOM 3187 O LEU A 400 -6.554 -8.105 -9.419 1.00 98.07 O \\\\nATOM 3188 CG LEU A 400 -6.121 -3.708 -8.840 1.00 98.07 C \\\\nATOM 3189 CD1 LEU A 400 -7.303 -2.837 -9.244 1.00 98.07 C \\\\nATOM 3190 CD2 LEU A 400 -5.657 -3.258 -7.451 1.00 98.07 C \\\\nATOM 3191 N ASN A 401 -5.706 -8.350 -7.354 1.00 97.27 N \\\\nATOM 3192 CA ASN A 401 -5.823 -9.807 -7.309 1.00 97.27 C \\\\nATOM 3193 C ASN A 401 -7.278 -10.291 -7.399 1.00 97.27 C \\\\nATOM 3194 CB ASN A 401 -5.159 -10.310 -6.019 1.00 97.27 C \\\\nATOM 3195 O ASN A 401 -7.529 -11.344 -7.975 1.00 97.27 O \\\\nATOM 3196 CG ASN A 401 -3.660 -10.068 -5.942 1.00 97.27 C \\\\nATOM 3197 ND2 ASN A 401 -3.127 -10.033 -4.747 1.00 97.27 N \\\\nATOM 3198 OD1 ASN A 401 -2.948 -9.899 -6.917 1.00 97.27 O \\\\nATOM 3199 N GLY A 402 -8.237 -9.532 -6.858 1.00 95.66 N \\\\nATOM 3200 CA GLY A 402 -9.663 -9.875 -6.913 1.00 95.66 C \\\\nATOM 3201 C GLY A 402 -10.217 -9.810 -8.341 1.00 95.66 C \\\\nATOM 3202 O GLY A 402 -10.705 -10.824 -8.843 1.00 95.66 O \\\\nATOM 3203 N PRO A 403 -10.083 -8.665 -9.040 1.00 96.62 N \\\\nATOM 3204 CA PRO A 403 -10.371 -8.549 -10.469 1.00 96.62 C \\\\nATOM 3205 C PRO A 403 -9.676 -9.615 -11.333 1.00 96.62 C \\\\nATOM 3206 CB PRO A 403 -9.945 -7.123 -10.839 1.00 96.62 C \\\\nATOM 3207 O PRO A 403 -10.339 -10.236 -12.160 1.00 96.62 O \\\\nATOM 3208 CG PRO A 403 -10.232 -6.348 -9.555 1.00 96.62 C \\\\nATOM 3209 CD PRO A 403 -9.818 -7.347 -8.476 1.00 96.62 C \\\\nATOM 3210 N LEU A 404 -8.385 -9.904 -11.099 1.00 96.80 N \\\\nATOM 3211 CA LEU A 404 -7.666 -10.983 -11.798 1.00 96.80 C \\\\nATOM 3212 C LEU A 404 -8.263 -12.371 -11.528 1.00 96.80 C \\\\nATOM 3213 CB LEU A 404 -6.174 -10.983 -11.410 1.00 96.80 C \\\\nATOM 3214 O LEU A 404 -8.483 -13.127 -12.468 1.00 96.80 O \\\\nATOM 3215 CG LEU A 404 -5.348 -9.857 -12.047 1.00 96.80 C \\\\nATOM 3216 CD1 LEU A 404 -3.952 -9.816 -11.431 1.00 96.80 C \\\\nATOM 3217 CD2 LEU A 404 -5.193 -10.022 -13.561 1.00 96.80 C \\\\nATOM 3218 N GLN A 405 -8.560 -12.711 -10.271 1.00 94.96 N \\\\nATOM 3219 CA GLN A 405 -9.154 -14.005 -9.921 1.00 94.96 C \\\\nATOM 3220 C GLN A 405 -10.559 -14.168 -10.515 1.00 94.96 C \\\\nATOM 3221 CB GLN A 405 -9.194 -14.155 -8.390 1.00 94.96 C \\\\nATOM 3222 O GLN A 405 -10.961 -15.273 -10.878 1.00 94.96 O \\\\nATOM 3223 CG GLN A 405 -9.640 -15.569 -7.985 1.00 94.96 C \\\\nATOM 3224 CD GLN A 405 -9.740 -15.779 -6.480 1.00 94.96 C \\\\nATOM 3225 NE2 GLN A 405 -9.435 -16.962 -5.997 1.00 94.96 N \\\\nATOM 3226 OE1 GLN A 405 -10.159 -14.935 -5.711 1.00 94.96 O \\\\nATOM 3227 N TRP A 406 -11.330 -13.084 -10.611 1.00 94.76 N \\\\nATOM 3228 CA TRP A 406 -12.641 -13.131 -11.250 1.00 94.76 C \\\\nATOM 3229 C TRP A 406 -12.522 -13.339 -12.760 1.00 94.76 C \\\\nATOM 3230 CB TRP A 406 -13.421 -11.861 -10.921 1.00 94.76 C \\\\nATOM 3231 O TRP A 406 -13.245 -14.162 -13.318 1.00 94.76 O \\\\nATOM 3232 CG TRP A 406 -14.901 -11.926 -11.139 1.00 94.76 C \\\\nATOM 3233 CD1 TRP A 406 -15.639 -13.020 -11.452 1.00 94.76 C \\\\nATOM 3234 CD2 TRP A 406 -15.853 -10.833 -11.027 1.00 94.76 C \\\\nATOM 3235 CE2 TRP A 406 -17.167 -11.362 -11.172 1.00 94.76 C \\\\nATOM 3236 CE3 TRP A 406 -15.734 -9.448 -10.788 1.00 94.76 C \\\\nATOM 3237 NE1 TRP A 406 -16.980 -12.692 -11.466 1.00 94.76 N \\\\nATOM 3238 CH2 TRP A 406 -18.161 -9.205 -10.753 1.00 94.76 C \\\\nATOM 3239 CZ2 TRP A 406 -18.308 -10.573 -11.020 1.00 94.76 C \\\\nATOM 3240 CZ3 TRP A 406 -16.875 -8.643 -10.643 1.00 94.76 C \\\\nATOM 3241 N LEU A 407 -11.569 -12.651 -13.393 1.00 95.07 N \\\\nATOM 3242 CA LEU A 407 -11.270 -12.788 -14.812 1.00 95.07 C \\\\nATOM 3243 C LEU A 407 -10.824 -14.213 -15.175 1.00 95.07 C \\\\nATOM 3244 CB LEU A 407 -10.192 -11.749 -15.164 1.00 95.07 C \\\\nATOM 3245 O LEU A 407 -11.353 -14.798 -16.115 1.00 95.07 O \\\\nATOM 3246 CG LEU A 407 -9.929 -11.642 -16.669 1.00 95.07 C \\\\nATOM 3247 CD1 LEU A 407 -11.149 -11.068 -17.375 1.00 95.07 C \\\\nATOM 3248 CD2 LEU A 407 -8.748 -10.715 -16.923 1.00 95.07 C \\\\nATOM 3249 N ASP A 408 -9.917 -14.797 -14.390 1.00 93.11 N \\\\nATOM 3250 CA ASP A 408 -9.437 -16.178 -14.539 1.00 93.11 C \\\\nATOM 3251 C ASP A 408 -10.587 -17.204 -14.477 1.00 93.11 C \\\\nATOM 3252 CB ASP A 408 -8.399 -16.419 -13.435 1.00 93.11 C \\\\nATOM 3253 O ASP A 408 -10.728 -18.059 -15.355 1.00 93.11 O \\\\nATOM 3254 CG ASP A 408 -7.860 -17.847 -13.445 1.00 93.11 C \\\\nATOM 3255 OD1 ASP A 408 -7.091 -18.163 -14.378 1.00 93.11 O \\\\nATOM 3256 OD2 ASP A 408 -8.220 -18.594 -12.507 1.00 93.11 O \\\\nATOM 3257 N LYS A 409 -11.502 -17.057 -13.508 1.00 92.52 N \\\\nATOM 3258 CA LYS A 409 -12.709 -17.897 -13.397 1.00 92.52 C \\\\nATOM 3259 C LYS A 409 -13.689 -17.758 -14.570 1.00 92.52 C \\\\nATOM 3260 CB LYS A 409 -13.466 -17.549 -12.121 1.00 92.52 C \\\\nATOM 3261 O LYS A 409 -14.478 -18.674 -14.795 1.00 92.52 O \\\\nATOM 3262 CG LYS A 409 -12.815 -18.012 -10.816 1.00 92.52 C \\\\nATOM 3263 CD LYS A 409 -13.636 -17.364 -9.697 1.00 92.52 C \\\\nATOM 3264 CE LYS A 409 -13.255 -17.844 -8.303 1.00 92.52 C \\\\nATOM 3265 NZ LYS A 409 -14.099 -17.132 -7.314 1.00 92.52 N \\\\nATOM 3266 N VAL A 410 -13.695 -16.619 -15.268 1.00 92.90 N \\\\nATOM 3267 CA VAL A 410 -14.493 -16.418 -16.489 1.00 92.90 C \\\\nATOM 3268 C VAL A 410 -13.777 -17.046 -17.685 1.00 92.90 C \\\\nATOM 3269 CB VAL A 410 -14.818 -14.925 -16.709 1.00 92.90 C \\\\nATOM 3270 O VAL A 410 -14.371 -17.866 -18.380 1.00 92.90 O \\\\nATOM 3271 CG1 VAL A 410 -15.438 -14.649 -18.082 1.00 92.90 C \\\\nATOM 3272 CG2 VAL A 410 -15.821 -14.432 -15.656 1.00 92.90 C \\\\nATOM 3273 N LEU A 411 -12.490 -16.743 -17.889 1.00 91.89 N \\\\nATOM 3274 CA LEU A 411 -11.679 -17.284 -18.988 1.00 91.89 C \\\\nATOM 3275 C LEU A 411 -11.652 -18.818 -18.994 1.00 91.89 C \\\\nATOM 3276 CB LEU A 411 -10.248 -16.723 -18.887 1.00 91.89 C \\\\nATOM 3277 O LEU A 411 -11.850 -19.428 -20.042 1.00 91.89 O \\\\nATOM 3278 CG LEU A 411 -10.117 -15.253 -19.320 1.00 91.89 C \\\\nATOM 3279 CD1 LEU A 411 -8.733 -14.724 -18.945 1.00 91.89 C \\\\nATOM 3280 CD2 LEU A 411 -10.290 -15.094 -20.834 1.00 91.89 C \\\\nATOM 3281 N THR A 412 -11.507 -19.444 -17.823 1.00 89.09 N \\\\nATOM 3282 CA THR A 412 -11.554 -20.911 -17.663 1.00 89.09 C \\\\nATOM 3283 C THR A 412 -12.888 -21.550 -18.070 1.00 89.09 C \\\\nATOM 3284 CB THR A 412 -11.218 -21.336 -16.222 1.00 89.09 C \\\\nATOM 3285 O THR A 412 -12.927 -22.757 -18.300 1.00 89.09 O \\\\nATOM 3286 CG2 THR A 412 -9.732 -21.190 -15.906 1.00 89.09 C \\\\nATOM 3287 OG1 THR A 412 -11.912 -20.558 -15.277 1.00 89.09 O \\\\nATOM 3288 N GLN A 413 -13.972 -20.775 -18.201 1.00 86.81 N \\\\nATOM 3289 CA GLN A 413 -15.280 -21.252 -18.672 1.00 86.81 C \\\\nATOM 3290 C GLN A 413 -15.551 -20.940 -20.153 1.00 86.81 C \\\\nATOM 3291 CB GLN A 413 -16.392 -20.705 -17.761 1.00 86.81 C \\\\nATOM 3292 O GLN A 413 -16.411 -21.583 -20.748 1.00 86.81 O \\\\nATOM 3293 CG GLN A 413 -16.258 -21.285 -16.347 1.00 86.81 C \\\\nATOM 3294 CD GLN A 413 -17.349 -20.835 -15.387 1.00 86.81 C \\\\nATOM 3295 NE2 GLN A 413 -17.067 -20.833 -14.103 1.00 86.81 N \\\\nATOM 3296 OE1 GLN A 413 -18.474 -20.520 -15.728 1.00 86.81 O \\\\nATOM 3297 N MET A 414 -14.802 -20.018 -20.773 1.00 85.54 N \\\\nATOM 3298 CA MET A 414 -14.980 -19.637 -22.185 1.00 85.54 C \\\\nATOM 3299 C MET A 414 -14.133 -20.455 -23.177 1.00 85.54 C \\\\nATOM 3300 CB MET A 414 -14.761 -18.132 -22.380 1.00 85.54 C \\\\nATOM 3301 O MET A 414 -14.115 -20.160 -24.369 1.00 85.54 O \\\\nATOM 3302 CG MET A 414 -15.737 -17.300 -21.541 1.00 85.54 C \\\\nATOM 3303 SD MET A 414 -15.963 -15.552 -21.980 1.00 85.54 S \\\\nATOM 3304 CE MET A 414 -14.405 -15.179 -22.806 1.00 85.54 C \\\\nATOM 3305 N GLY A 415 -13.432 -21.496 -22.723 1.00 82.14 N \\\\nATOM 3306 CA GLY A 415 -12.658 -22.373 -23.604 1.00 82.14 C \\\\nATOM 3307 C GLY A 415 -11.343 -21.744 -24.076 1.00 82.14 C \\\\nATOM 3308 O GLY A 415 -10.474 -21.450 -23.260 1.00 82.14 O \\\\nATOM 3309 N SER A 416 -11.159 -21.607 -25.392 1.00 81.44 N \\\\nATOM 3310 CA SER A 416 -9.897 -21.178 -26.015 1.00 81.44 C \\\\nATOM 3311 C SER A 416 -10.125 -20.213 -27.186 1.00 81.44 C \\\\nATOM 3312 CB SER A 416 -9.114 -22.408 -26.502 1.00 81.44 C \\\\nATOM 3313 O SER A 416 -11.213 -20.226 -27.766 1.00 81.44 O \\\\nATOM 3314 OG SER A 416 -9.784 -23.090 -27.551 1.00 81.44 O \\\\nATOM 3315 N PRO A 417 -9.103 -19.446 -27.618 1.00 82.09 N \\\\nATOM 3316 CA PRO A 417 -9.158 -18.678 -28.861 1.00 82.09 C \\\\nATOM 3317 C PRO A 417 -9.571 -19.530 -30.072 1.00 82.09 C \\\\nATOM 3318 CB PRO A 417 -7.753 -18.096 -29.059 1.00 82.09 C \\\\nATOM 3319 O PRO A 417 -9.239 -20.715 -30.158 1.00 82.09 O \\\\nATOM 3320 CG PRO A 417 -7.186 -18.034 -27.644 1.00 82.09 C \\\\nATOM 3321 CD PRO A 417 -7.814 -19.252 -26.967 1.00 82.09 C \\\\nATOM 3322 N SER A 418 -10.262 -18.910 -31.031 1.00 80.99 N \\\\nATOM 3323 CA SER A 418 -10.662 -19.545 -32.296 1.00 80.99 C \\\\nATOM 3324 C SER A 418 -9.466 -19.816 -33.218 1.00 80.99 C \\\\nATOM 3325 CB SER A 418 -11.680 -18.649 -33.011 1.00 80.99 C \\\\nATOM 3326 O SER A 418 -9.413 -20.846 -33.893 1.00 80.99 O \\\\nATOM 3327 OG SER A 418 -11.172 -17.331 -33.132 1.00 80.99 O \\\\nATOM 3328 N ILE A 419 -8.483 -18.912 -33.221 1.00 81.26 N \\\\nATOM 3329 CA ILE A 419 -7.231 -19.055 -33.965 1.00 81.26 C \\\\nATOM 3330 C ILE A 419 -6.295 -19.973 -33.174 1.00 81.26 C \\\\nATOM 3331 CB ILE A 419 -6.594 -17.676 -34.263 1.00 81.26 C \\\\nATOM 3332 O ILE A 419 -5.882 -19.659 -32.058 1.00 81.26 O \\\\nATOM 3333 CG1 ILE A 419 -7.578 -16.783 -35.058 1.00 81.26 C \\\\nATOM 3334 CG2 ILE A 419 -5.278 -17.863 -35.045 1.00 81.26 C \\\\nATOM 3335 CD1 ILE A 419 -7.081 -15.352 -35.301 1.00 81.26 C \\\\nATOM 3336 N ARG A 420 -5.929 -21.114 -33.767 1.00 83.97 N \\\\nATOM 3337 CA ARG A 420 -4.920 -22.014 -33.193 1.00 83.97 C \\\\nATOM 3338 C ARG A 420 -3.526 -21.423 -33.385 1.00 83.97 C \\\\nATOM 3339 CB ARG A 420 -5.003 -23.414 -33.814 1.00 83.97 C \\\\nATOM 3340 O ARG A 420 -3.164 -21.055 -34.499 1.00 83.97 O \\\\nATOM 3341 CG ARG A 420 -6.335 -24.106 -33.502 1.00 83.97 C \\\\nATOM 3342 CD ARG A 420 -6.312 -25.543 -34.028 1.00 83.97 C \\\\nATOM 3343 NE ARG A 420 -7.597 -26.219 -33.779 1.00 83.97 N \\\\nATOM 3344 NH1 ARG A 420 -6.954 -28.339 -34.384 1.00 83.97 N \\\\nATOM 3345 NH2 ARG A 420 -9.053 -27.965 -33.716 1.00 83.97 N \\\\nATOM 3346 CZ ARG A 420 -7.860 -27.500 -33.960 1.00 83.97 C \\\\nATOM 3347 N CYS A 421 -2.733 -21.398 -32.318 1.00 83.68 N \\\\nATOM 3348 CA CYS A 421 -1.320 -21.044 -32.406 1.00 83.68 C \\\\nATOM 3349 C CYS A 421 -0.531 -22.142 -33.143 1.00 83.68 C \\\\nATOM 3350 CB CYS A 421 -0.786 -20.779 -30.993 1.00 83.68 C \\\\nATOM 3351 O CYS A 421 -0.792 -23.334 -32.955 1.00 83.68 O \\\\nATOM 3352 SG CYS A 421 0.817 -19.947 -31.129 1.00 83.68 S \\\\nATOM 3353 N SER A 422 0.433 -21.746 -33.976 1.00 85.93 N \\\\nATOM 3354 CA SER A 422 1.379 -22.670 -34.607 1.00 85.93 C \\\\nATOM 3355 C SER A 422 2.461 -23.078 -33.607 1.00 85.93 C \\\\nATOM 3356 CB SER A 422 2.006 -22.014 -35.839 1.00 85.93 C \\\\nATOM 3357 O SER A 422 2.934 -22.264 -32.823 1.00 85.93 O \\\\nATOM 3358 OG SER A 422 3.003 -22.843 -36.411 1.00 85.93 O \\\\nATOM 3359 N SER A 423 2.904 -24.335 -33.658 1.00 89.58 N \\\\nATOM 3360 CA SER A 423 4.051 -24.816 -32.874 1.00 89.58 C \\\\nATOM 3361 C SER A 423 5.402 -24.609 -33.580 1.00 89.58 C \\\\nATOM 3362 CB SER A 423 3.834 -26.286 -32.505 1.00 89.58 C \\\\nATOM 3363 O SER A 423 6.389 -25.223 -33.179 1.00 89.58 O \\\\nATOM 3364 OG SER A 423 3.847 -27.096 -33.667 1.00 89.58 O \\\\nATOM 3365 N VAL A 424 5.430 -23.853 -34.686 1.00 86.04 N \\\\nATOM 3366 CA VAL A 424 6.582 -23.732 -35.608 1.00 86.04 C \\\\nATOM 3367 C VAL A 424 6.860 -22.279 -36.040 1.00 86.04 C \\\\nATOM 3368 CB VAL A 424 6.367 -24.626 -36.861 1.00 86.04 C \\\\nATOM 3369 O VAL A 424 7.895 -22.021 -36.645 1.00 86.04 O \\\\nATOM 3370 CG1 VAL A 424 7.640 -24.833 -37.700 1.00 86.04 C \\\\nATOM 3371 CG2 VAL A 424 5.872 -26.041 -36.507 1.00 86.04 C \\\\nATOM 3372 N SER A 425 5.935 -21.348 -35.773 1.00 67.52 N \\\\nATOM 3373 CA SER A 425 6.045 -19.920 -36.132 1.00 67.52 C \\\\nATOM 3374 C SER A 425 7.004 -19.152 -35.232 1.00 67.52 C \\\\nATOM 3375 CB SER A 425 4.678 -19.249 -36.048 1.00 67.52 C \\\\nATOM 3376 O SER A 425 6.854 -19.333 -34.002 1.00 67.52 O \\\\nATOM 3377 OG SER A 425 4.186 -19.498 -34.749 1.00 67.52 O \\\\nATOM 3378 OXT SER A 425 7.754 -18.328 -35.788 1.00 67.52 O \\\\nTER 3379 SER A 425 \\\\nENDMDL \\\\nEND ', 'biolip2': [], 'cysdb_hyperreactive': [{'residue_no': 1, 'score': 0}, {'residue_no': 2, 'score': 0}, {'residue_no': 3, 'score': 0}, {'residue_no': 4, 'score': 0}, {'residue_no': 5, 'score': 0}, {'residue_no': 6, 'score': 0}, {'residue_no': 7, 'score': 0}, {'residue_no': 8, 'score': 0}, {'residue_no': 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'ASP118', 119: 'GLU119', 120: 'VAL120', 121: 'CYS121', 122: 'VAL122', 123: 'ASN123', 124: 'PRO124', 125: 'TYR125', 126: 'HIS126', 127: 'TYR127', 128: 'GLN128', 129: 'ARG129', 130: 'VAL130', 131: 'GLU131', 132: 'THR132', 133: 'PRO133', 134: 'VAL134', 135: 'LEU135', 136: 'PRO136', 137: 'PRO137', 138: 'VAL138', 139: 'LEU139', 140: 'VAL140', 141: 'PRO141', 142: 'ARG142', 143: 'HIS143', 144: 'THR144', 145: 'GLU145', 146: 'ILE146', 147: 'PRO147', 148: 'ALA148', 149: 'GLU149', 150: 'PHE150', 151: 'PRO151', 152: 'PRO152', 153: 'LEU153', 154: 'ASP154', 155: 'ASP155', 156: 'TYR156', 157: 'SER157', 158: 'HIS158', 159: 'SER159', 160: 'ILE160', 161: 'PRO161', 162: 'GLU162', 163: 'ASN163', 164: 'THR164', 165: 'ASN165', 166: 'PHE166', 167: 'PRO167', 168: 'ALA168', 169: 'GLY169', 170: 'ILE170', 171: 'GLU171', 172: 'PRO172', 173: 'GLN173', 174: 'SER174', 175: 'ASN175', 176: 'ILE176', 177: 'PRO177', 178: 'GLU178', 179: 'THR179', 180: 'PRO180', 181: 'PRO181', 182: 'PRO182', 183: 'GLY183', 184: 'TYR184', 185: 'LEU185', 186: 'SER186', 187: 'GLU187', 188: 'ASP188', 189: 'GLY189', 190: 'GLU190', 191: 'THR191', 192: 'SER192', 193: 'ASP193', 194: 'HIS194', 195: 'GLN195', 196: 'MET196', 197: 'ASN197', 198: 'HIS198', 199: 'SER199', 200: 'MET200', 201: 'ASP201', 202: 'ALA202', 203: 'GLY203', 204: 'SER204', 205: 'PRO205', 206: 'ASN206', 207: 'LEU207', 208: 'SER208', 209: 'PRO209', 210: 'ASN210', 211: 'PRO211', 212: 'MET212', 213: 'SER213', 214: 'PRO214', 215: 'ALA215', 216: 'HIS216', 217: 'ASN217', 218: 'ASN218', 219: 'LEU219', 220: 'ASP220', 221: 'LEU221', 222: 'GLN222', 223: 'PRO223', 224: 'VAL224', 225: 'THR225', 226: 'TYR226', 227: 'CYS227', 228: 'GLU228', 229: 'PRO229', 230: 'ALA230', 231: 'PHE231', 232: 'TRP232', 233: 'CYS233', 234: 'SER234', 235: 'ILE235', 236: 'SER236', 237: 'TYR237', 238: 'TYR238', 239: 'GLU239', 240: 'LEU240', 241: 'ASN241', 242: 'GLN242', 243: 'ARG243', 244: 'VAL244', 245: 'GLY245', 246: 'GLU246', 247: 'THR247', 248: 'PHE248', 249: 'HIS249', 250: 'ALA250', 251: 'SER251', 252: 'GLN252', 253: 'PRO253', 254: 'SER254', 255: 'MET255', 256: 'THR256', 257: 'VAL257', 258: 'ASP258', 259: 'GLY259', 260: 'PHE260', 261: 'THR261', 262: 'ASP262', 263: 'PRO263', 264: 'SER264', 265: 'ASN265', 266: 'SER266', 267: 'GLU267', 268: 'ARG268', 269: 'PHE269', 270: 'CYS270', 271: 'LEU271', 272: 'GLY272', 273: 'LEU273', 274: 'LEU274', 275: 'SER275', 276: 'ASN276', 277: 'VAL277', 278: 'ASN278', 279: 'ARG279', 280: 'ASN280', 281: 'ALA281', 282: 'ALA282', 283: 'VAL283', 284: 'GLU284', 285: 'LEU285', 286: 'THR286', 287: 'ARG287', 288: 'ARG288', 289: 'HIS289', 290: 'ILE290', 291: 'GLY291', 292: 'ARG292', 293: 'GLY293', 294: 'VAL294', 295: 'ARG295', 296: 'LEU296', 297: 'TYR297', 298: 'TYR298', 299: 'ILE299', 300: 'GLY300', 301: 'GLY301', 302: 'GLU302', 303: 'VAL303', 304: 'PHE304', 305: 'ALA305', 306: 'GLU306', 307: 'CYS307', 308: 'LEU308', 309: 'SER309', 310: 'ASP310', 311: 'SER311', 312: 'ALA312', 313: 'ILE313', 314: 'PHE314', 315: 'VAL315', 316: 'GLN316', 317: 'SER317', 318: 'PRO318', 319: 'ASN319', 320: 'CYS320', 321: 'ASN321', 322: 'GLN322', 323: 'ARG323', 324: 'TYR324', 325: 'GLY325', 326: 'TRP326', 327: 'HIS327', 328: 'PRO328', 329: 'ALA329', 330: 'THR330', 331: 'VAL331', 332: 'CYS332', 333: 'LYS333', 334: 'ILE334', 335: 'PRO335', 336: 'PRO336', 337: 'GLY337', 338: 'CYS338', 339: 'ASN339', 340: 'LEU340', 341: 'LYS341', 342: 'ILE342', 343: 'PHE343', 344: 'ASN344', 345: 'ASN345', 346: 'GLN346', 347: 'GLU347', 348: 'PHE348', 349: 'ALA349', 350: 'ALA350', 351: 'LEU351', 352: 'LEU352', 353: 'ALA353', 354: 'GLN354', 355: 'SER355', 356: 'VAL356', 357: 'ASN357', 358: 'GLN358', 359: 'GLY359', 360: 'PHE360', 361: 'GLU361', 362: 'ALA362', 363: 'VAL363', 364: 'TYR364', 365: 'GLN365', 366: 'LEU366', 367: 'THR367', 368: 'ARG368', 369: 'MET369', 370: 'CYS370', 371: 'THR371', 372: 'ILE372', 373: 'ARG373', 374: 'MET374', 375: 'SER375', 376: 'PHE376', 377: 'VAL377', 378: 'LYS378', 379: 'GLY379', 380: 'TRP380', 381: 'GLY381', 382: 'ALA382', 383: 'GLU383', 384: 'TYR384', 385: 'ARG385', 386: 'ARG386', 387: 'GLN387', 388: 'THR388', 389: 'VAL389', 390: 'THR390', 391: 'SER391', 392: 'THR392', 393: 'PRO393', 394: 'CYS394', 395: 'TRP395', 396: 'ILE396', 397: 'GLU397', 398: 'LEU398', 399: 'HIS399', 400: 'LEU400', 401: 'ASN401', 402: 'GLY402', 403: 'PRO403', 404: 'LEU404', 405: 'GLN405', 406: 'TRP406', 407: 'LEU407', 408: 'ASP408', 409: 'LYS409', 410: 'VAL410', 411: 'LEU411', 412: 'THR412', 413: 'GLN413', 414: 'MET414', 415: 'GLY415', 416: 'SER416', 417: 'PRO417', 418: 'SER418', 419: 'ILE419', 420: 'ARG420', 421: 'CYS421', 422: 'SER422', 423: 'SER423', 424: 'VAL424', 425: 'SER425'}}}}\\n[TOOL RUN] → BioGRID\\n[BioGRID] Fetching predictions for gene symbol: SMAD2\\n[BioGRID] Fetching predictions for gene symbol: SMAD3\\n[BioGRID] Predictions fetched\\n[TOOL SELECTION] Selecting additional tools based on current state.\\n[create_context_block function] preparing context block...\\n****************************************\\n****************************************\\n[create_context_block] genes to summarize: ['SMAD3', 'SMAD2']\\n[TOOL SELECTION PROMPT] You are an assistant deciding which tools to use to answer a biomedical question. User question: \\\"\\\"\\\"Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues\\\"\\\"\\\" \\n\\n If the question mentioned a database or tool and we do not have it, use the most similar available ones. If there are multiple tools with complementary or similar information, you are allowed to use complementary tools. However, avoid calling tools that create long context unless needed to answer the question. Try to get as much relevant information as possible. Available tools: - extract_entities: Extract genes and biomedical entities from the user question. This must run before any downstream tool to populate gene/trait context.\\n- aa_seq: Resolve amino acid sequences (not gene symbols) to UniProt and gene-level information using a local copy of the UniProt database. The tool updates per-gene text summaries and returns both a structured result, a global text summary, and an interactive HTML viewer for AA-sequence mappings.\\n- AllianceOfGenomes: Fetches species-specific gene summary descriptions from the Alliance of Genome Resources, a consortium integrating curated data from major model organism databases for yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans), fruit fly (Drosophila melanogaster), zebrafish (Danio rerio), mouse (Mus musculus), rat (Rattus norvegicus), and frog (Xenopus species). The returned summaries provide high-level functional and biological context for the input genes across available model organisms (for example, core molecular function, conserved biological roles, and representative phenotypes described in model systems).\\n- alphamissense: Fetches Alphamissense predicted pathogenicity classes for given variants. This requires variant_annotations to be run first.\\n- BioGRID: Fetches gene interactions from BioGRID for the input genes. Provides a curated context-specific list of protein-protein, genetic and chemical interactions.\\n- chembl: Query ChEMBL for drug-target information about one or more genes, finding whether there are any drugs targeting this gene and their status. Specifically, this tool summarizes FDA-approved drugs (with black-box, withdrawn, indication, MoA), clinical and preclinical trials, and assay bioactivity data. Generates text summaries and an interactive HTML viewer with 2D molecular renderings.\\n- clinvar_gene_node: Annotates genes with ClinVar gene–disease associations (disease name, source, last updated). \\n- clinvar_variants_node: Retrieves pathogenic and likely pathogenic variants for input genes (rsID, variant type, name, clinical significance) from the ClinVar database. Should only be called if exact variant information such as amino acid substitution or variant ID is required to answer the question, otherwise use ClinVar gene-level. Might create excessively long context for commonly implicated genes.\\n- variant_annotations: Annotate existing variants with dbSNP coordinates and context required by downstream nodes.\\n- variant_population_summaries: Extend dbSNP annotations with population frequency summaries for each variant. Useful for characterizing the frequency of variants in the population.\\n- DisGeNet: Fetches information about disease annotations for the input genes from DisGeNet, which provides curated data linking human genes to a wide range of diseases, including Mendelian, complex, environmental, and rare diseases.\\n- drug_central: Query Drug Central for drug-centric information given one or more drugs identified by name, synonym, ChEMBL ID, CAS number, struct_id, or external IDs. Summarizes drug description, information, structural properties, regulatory status, pharmacologic actions, HUMAN gene-level targets (MoA and off-target), indications, contraindications, FAERS safety signals, and cross references, with text summaries and an optional interactive HTML viewer.\\n- gencode_gene_node: Annotate genes with GENCODE metadata (transcripts, spans, gene type, number of exons). Essential for many downstream analyses.\\n- Summarize_GO: Summarizes GO terms for the input genes, to condense long list into representative terms.\\n- Summarize_bioGRID_GO: This is a summarized version of BIOGRID that queries BioGRID but returns summarized GO enrichment rather than individual interactors. Use when individual interactor names are not needed or a summary of interactions would be helpful to answer the query. Provides a summarized list of GO terms significantly enriched for the interacting genes of each input gene fetched from BioGRID.\\n- query_gwas_by_gene: Retrieves genome-wide association study (GWAS) results for a given gene. It collects traits and diseases associated with genetic variants linked to that gene, along with the specific variants\\n- query_gwas_extensive: This is a more comprehensive version of the query_gwas_by_gene tool, and it is used to retrieve more detailed information about the GWAS results. It collects an extensive list of traits/diseases associated with an extensive list of genetic variants linked to that gene. Use this tool *ONLY* if the question is very specific that requires what is equivalent to an extensive database search, not to general characterisation of the gene.\\n- humanbase_functions: Fetch per-gene functional predictions from HumanBase tissue-specific networks. Provides expanded list of functions.\\n- expectosc_predictions_agent: Annotates variants with predicted (from sequence) cell type-specific expression disruption predictions. Requires variant_annotations to be run first\\n- intact_viral: Fetches curated host–virus molecular interactions from the IntAct Virus dataset, reporting experimentally supported protein–protein interactions between host genes/proteins and viral proteins, with organism and taxon context for each interactor.\\n- miRDB: Looks up predicted target genes for the miRNA of interest using miRDB, with organism-specific predictions.\\n- MSigDB: Fetches MSigDB annotations for input genes across collections (H, C1–C8), including hallmark biological processes, positional cytogenetic bands per gene, curated pathways, regulatory target information (e.g. transcription-factor binding in promoter region of the gene and miRNAs predicted to target this gene), computational signatures from cancer-oriented expression data, oncogenic signatures of pathways dysregulated in cancer, immunologic signatures, and cell-type markers.\\n- OMIM: Fetches curated OMIM entries describing Mendelian disease phenotypes caused by pathogenic variants in the input genes, including clinical features, inheritance patterns, and molecular genetic evidence.\\n- OpenTargets: Fetches target-disease associations, tissue-specific expression, essentiality, genetic constraint for synonymous, missense, and loss-of-function variants, associations between target genes and drug-induced adverse effects, and variant to drug response associations from Open Targets for the input genes.\\n- prot: Visualize AlphaFold-predicted protein structures for one or more genes. Overlays include: per-residue confidence scores (pLDDT, AlphaFold); pocket druggability and geometric features (FPocket); solvent-accessible surface area and polarity index (FreeSASA); intrinsic disorder consensus (IUPred3 + DisProt); MoRF propensity predictions (IUPred3/ANCHOR2); ligand-binding evidence (BioLiP2 + ChEMBL); and cysteine chemoproteomics annotations from CysDB, including detected, ligandable, hyperreactive, and active-site or binding-site–proximal cysteines. Generates interactive 3Dmol.js views with color-coded surfaces, binding-site context, summary statistics, and interpretation notes.\\n- reactome: Fetches Reactome pathways associated with the input genes, providing curated, expert-reviewed pathway information that describe molecular interactions, signaling cascades, and biological processes in which the genes participate.\\n- remap_crm_agent: Fetches cis-regulatory modules (CRMs) from the ReMap 2022 database that are proximal to the transcription start site (TSS) of the input genes. Reports transcription factors with supporting ChIP-seq binding evidence overlapping these regions. Requires GENCODE annotation (gencode_gene_node) to be run first. Useful for exploratory analysis of potential transcriptional regulatory contexts.\\n- sei: Fetches predictions of the sequence regulatory activity for given variants. This requires variant_annotations to be run first.\\n- uniprot_base: Fetch UniProt entries for genes, extracting diseases, GO terms, and isoform annotations. Helps to expand the base annotations.\\n- uniprot_gwas: Fetch UniProt entries for genes, extracting diseases, GO terms, and isoform annotations. Helps to expand the base annotations..\\n\\n Examples selection and outputs: EXAMPLE PIPELINES (pay attention to dependencies):\\n\\n1. Variant regulatory activity:\\n [\\\"extract_entities\\\", \\\"gencode_gene_node\\\", \\\"query_gwas_by_gene\\\", \\\"variant_annotations\\\", \\\"sei\\\", \\\"expectosc_predictions_agent\\\", \\\"remap_crm_agent\\\"]\\n\\n2. Variant pathogenicity:\\n [\\\"extract_entities\\\", \\\"query_gwas_by_gene\\\", \\\"variant_annotations\\\", \\\"alphamissense\\\"] \\n\\n3. Gene-level functional annotation:\\n [\\\"extract_entities\\\", \\\"gencode_gene_node\\\", \\\"humanbase_functions\\\", \\\"uniprot_base\\\", \\\"reactome\\\", \\\"Summarize_bioGRID_GO\\\", \\\"uniprot_gwas\\\", 'clinvar_gene_node']\\n\\n4. Protein structure, visualization and druggability:\\n [\\\"extract_entities\\\", \\\"prot\\\", \\\"chembl\\\", \\\"drug_central\\\", \\\"MSigDB\\\"]\\n \\n5. Protein-protein interactions and gene function questions summaries: \\n [\\\"extract_entities\\\", \\\"Summarize_bioGRID_GO\\\", \\\"Summarize_GO\\\", \\\"AllianceOfGenomes\\\"]\\n \\n6. Specific protein-protein interactions and gene function questions: \\n [\\\"extract_entities\\\", \\\"BioGRID\\\", \\\"reactome\\\", \\\"intact_viral\\\"]\\n \\nNote these are only examples, and in real life you may need to run combinations of these tools **depending on the user intent and the entities extracted**.\\n\\nRespond *ONLY* with a Python list of tool names. Example: [\\\"humanbase_functions\\\", \\\"uniprot_base\\\"] or [\\\"humanbase_functions\\\", \\\"uniprot_base\\\", \\\"query_gwas_by_gene\\\"] or [\\\"query_gwas_by_gene\\\", \\\"BioGRID\\\"]\\n\\nDo not include any explanations or extra text outside the list.\\n\\n\\nAlready used tools: BioGRID, MSigDB, chembl, drug_central, extract_entities, prot, uniprot_base\\nDo not repeat tools already used.\\nBased on the current context block, select ADDITIONAL tools needed to answer the question.\\nBe inclusive in tool selection. Include tools with possible relevance, not just certain relevance. For example in variant questions be thorough and unless specified use all variant models available.\\nIMPORTANT: if no additional tools are needed, return [] with no explanation.\\nOverall, NO explanation, downstream parser can only work with a list of tools.\\n\\nCurrent context block:\\n• Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 • Transcripts: n_transcripts=0: • Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 • Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 • Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 • Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 • Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 • Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 • Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 • Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 • Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A • Interactions from human data (FRET): SMAD4, STUB1 • Interactions from human data (PCA): SMAD4, SMAD7 • Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 • Interactions from human data (Phenotypic Suppression): SMAD7, STRAP • Interactions from human data (Positive Genetic): JAK1 • Interactions from human data (Protein-RNA): LINC00941 • Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 • Interactions from human data (Proximity Label-MS): NFIA • Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 • Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 • Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 • Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 • Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 • Interactions from additional (non-human) data: (Co-localization): E7, N • Interactions from additional (non-human) data: (PCA): E6 • Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A • Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A • Interactions from additional (non-human) data: (Proximity Label-MS): M • Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 • Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 • Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 • *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 • *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004. • *ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 • *ChEMBL: Interpretation Notes - Bioactivity values are normalized to nM and aggregated per compound. - Only positive numeric IC50 / Ki / EC50 values with molar units were considered. - Reported values are the lowest (strongest) potency observed per assay type. - pChEMBL is -log10(molar potency): higher values = stronger activity. - Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.). - Canonical SMILES are provided for RDKit.js 2D rendering. - InChIKeys are provided for PubChem enrichment. - Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available). - Black-box text and FDA label links are retrieved from the openFDA API. - Schema version = 35.0 (local snapshot). - These summaries are heuristic and not a substitute for experimental validation. • *MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE. • *UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.\\n• Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 • Transcripts: n_transcripts=0: • Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 • Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 • Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 • Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 • Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 • Interactions from human data (Co-crystal Structure): SMAD4 • Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 • Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 • Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 • Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 • Interactions from human data (Phenotypic Suppression): SMAD7, STRAP • Interactions from human data (Positive Genetic): SPPL3 • Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 • Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 • Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 • Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 • Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 • Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 • Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 • Interactions from additional (non-human) data: (PCA): E6, SMOX • Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI • Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX • Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 • Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN • *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 • *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. • *MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: . • *UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.\\n\\n No other words should be included in the response.\\n[TOOL SELECTION RESPONSE][claude-sonnet-4-5-20250929] Message(id='msg_01XYmEzVXjAczj9kyY4qhHYq', content=[TextBlock(citations=None, text='[\\\"OpenTargets\\\", \\\"reactome\\\", \\\"humanbase_functions\\\", \\\"Summarize_GO\\\"]', type='text')], model='claude-sonnet-4-5-20250929', role='assistant', stop_reason='end_turn', stop_sequence=None, type='message', usage=Usage(cache_creation_input_tokens=0, cache_read_input_tokens=0, input_tokens=26772, output_tokens=25, server_tool_use=None, service_tier='standard', cache_creation={'ephemeral_5m_input_tokens': 0, 'ephemeral_1h_input_tokens': 0}))\\n[TOOL SELECTION] Selected tools: ['OpenTargets', 'reactome', 'humanbase_functions', 'Summarize_GO']\\n[TOOL INVOKE] Selected tools: ['OpenTargets', 'reactome', 'humanbase_functions', 'Summarize_GO']\\n[TOOL INVOKE] Already used tools: ['BioGRID', 'MSigDB', 'chembl', 'drug_central', 'extract_entities', 'prot', 'uniprot_base']\\n*NAME* OpenTargets\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': ['SMAD2', 'SMAD3'], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id='Q15796', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma'], diseases=['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['SMAD3', 'SMAD4', 'SMURF2'], 'Affinity Capture-MS': ['ARID1A', 'ARID1B', 'ASH2L', 'ATAD3B', 'BCL7A', 'BTBD9', 'BUB3', 'C1ORF116', 'CAD', 'CCT6A', 'CDC27', 'CGA', 'CPSF7', 'CREBBP', 'CSNK1D', 'CTNNB1', 'CUL4A', 'CUL4B', 'DCAF7', 'DDX3Y', 'DGKA', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'EPB41L5', 'ERBB2IP', 'EZH2', 'FAM83G', 'FLOT1', 'FLOT2', 'FYN', 'GSK3A', 'GTF3C2', 'GTF3C6', 'HCFC1', 'HDAC2', 'HDAC4', 'HINT3', 'HSPA4', 'ITGB4', 'KLF5', 'KMT2C', 'LDLRAD4', 'LEMD3', 'MED15', 'MED16', 'MED17', 'MED19', 'MED20', 'MED22', 'MED25', 'MED31', 'MED4', 'MED9', 'MEN1', 'MTMR4', 'NCOA3', 'OGT', 'OPA1', 'OTUB1', 'PARK2', 'PCBP1', 'PCID2', 'PLEKHA4', 'PSPC1', 'RIN1', 'SGSH', 'SIK3', 'SKI', 'SKIL', 'SLC25A3', 'SLC25A5', 'SLC25A6', 'SMAD1', 'SMAD3', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMARCD2', 'SMPDL3B', 'SMURF2', 'SNW1', 'SNX27', 'SQRDL', 'TAF1', 'TAF2', 'TAF3', 'TAF5', 'TAF6', 'TMED8', 'TMOD1', 'TRIM28', 'TRIM33', 'TRIM67', 'U2AF2', 'WDR82', 'WRNIP1', 'WWP2', 'YAF2', 'YY1', 'ZFYVE9'], 'Affinity Capture-RNA': ['DDX58', 'ELAVL1'], 'Affinity Capture-Western': ['ACVR1B', 'ACVR2B', 'AKT1', 'ANAPC10', 'ATF3', 'BRCA2', 'CDC16', 'CDC27', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DAB2', 'DOCK9', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'ETV4', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'FOXP1', 'GLI1', 'GTF2I', 'GTF2IRD1', 'HDAC1', 'HGS', 'HYAL2', 'ING2', 'INSR', 'IRF3', 'IRF7', 'ITCH', 'JUN', 'KAT2A', 'KAT2B', 'KDM6B', 'KLF5', 'LEF1', 'MAPT', 'MED15', 'MED24', 'MED6', 'MEF2A', 'METTL14', 'METTL3', 'MYC', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFYC', 'NOTCH4', 'NUP214', 'OTUB1', 'OVOL2', 'PIAS3', 'PIAS4', 'PIN1', 'PML', 'PRDM16', 'RBBP5', 'RELB', 'RGCC', 'RNF111', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD6', 'SMAD7', 'SMARCA4', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'STRAP', 'TCF12', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TP53', 'TRIM28', 'TRIM33', 'TSC2', 'UCHL1', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWP1', 'WWP2', 'YAP1', 'ZEB1', 'ZFYVE9'], 'Biochemical Activity': ['ACVR1B', 'CAMK2G', 'CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'ITCH', 'TGFBR1'], 'Co-crystal Structure': ['SMAD4'], 'Co-fractionation': ['AP1M1', 'ARID1B', 'CAV1', 'CREBBP', 'CTNNB1', 'HDAC1', 'HMGA2', 'MTA2', 'NAA15', 'NCOA3', 'PARP1', 'PML', 'PRKDC', 'RBM14', 'RELA', 'SMAD3', 'SMAD4', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SUB1', 'TGFBR1', 'TRIM33', 'XRCC6', 'ZFYVE9'], 'Co-localization': ['CAMK2A', 'TGFBR1', 'TP53'], 'FRET': ['BECN1', 'LATS2', 'MYC', 'SMAD1'], 'Phenotypic Enhancement': ['SMAD3', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['SPPL3'], 'Proximity Label-MS': ['CCNF', 'EPHA2', 'OPTN', 'RAB7A', 'SNCA', 'TGOLN2'], 'Reconstituted Complex': ['ANAPC10', 'ANP32B', 'ANP32E', 'ATP5I', 'BPTF', 'CREBBP', 'DAB2', 'DVL1', 'ELAC2', 'ERBB2IP', 'ESR1', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'HDAC2', 'HIPK2', 'HYAL2', 'INSR', 'IRF7', 'JUN', 'KAT2B', 'LCK', 'LEF1', 'MECOM', 'MEF2A', 'MEF2C', 'MYC', 'MYOCD', 'NEDD4L', 'NEFM', 'NFIA', 'NUP214', 'OTUB1', 'PARD3', 'PIAS3', 'PIK3CA', 'PIN1', 'PTMS', 'RHOA', 'SH2D2A', 'SKI', 'SMAD4', 'SMAD7', 'SMURF2', 'SNW1', 'SOD1', 'SP1', 'STUB1', 'SYT1', 'TP53', 'TUBA1B', 'UCHL5', 'YY1', 'ZFYVE9'], 'Two-hybrid': ['ABTB1', 'AKT1', 'ANAPC2', 'ANK3', 'ANTXR2', 'BAZ1A', 'BTBD2', 'C22ORF46', 'C9ORF156', 'CISH', 'COPS5', 'CORO2A', 'CREBBP', 'CSH1', 'CSH2', 'CUL5', 'CYLC2', 'CYP11A1', 'DCUN1D1', 'DNAJB5', 'DNAJC7', 'DOCK8', 'DYNC1H1', 'DYRK1A', 'EEF1A1', 'EIF3L', 'EP300', 'ETV4', 'FAM161B', 'FBP2', 'FOXH1', 'GATAD2B', 'GFER', 'HSD17B3', 'INSR', 'KHDRBS1', 'KIAA1033', 'KPNB1', 'LAMA5', 'LEMD3', 'MAP2K1', 'MLLT4', 'MYC', 'NAGK', 'NCOA6', 'NEDD4L', 'OS9', 'PAPOLA', 'PAPPA', 'PAXIP1', 'PEX19', 'PIAS4', 'PLIN3', 'POU2AF1', 'PPP2R1A', 'PRKAR1A', 'PSAP', 'PSG9', 'PSMD11', 'PSMD8', 'RANBP6', 'RANBP9', 'RARB', 'RASA1', 'RNF123', 'RNPC3', 'ROCK1', 'RPS14', 'RPS27A', 'RXRA', 'SKI', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD9', 'SMURF1', 'SMURF2', 'SNAPIN', 'SNIP1', 'SNRNP70', 'SNW1', 'SP1', 'SRI', 'ST13', 'ST5', 'TBC1D1', 'TGIF1', 'TGM2', 'TRIM62', 'UBA52', 'UBR5', 'XPA', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF41', 'ZNF510', 'ZNHIT6']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF1', 'ARHGEF6', 'ARHGEF7', 'ARL4D', 'CDC40', 'FBXO3', 'IRAK2', 'LHX9', 'LMO2', 'MAP2K3', 'NUAK2', 'PPP2R2D', 'RAB34', 'RAB38', 'RASD2', 'RGS3', 'RHEBL1', 'RHOBTB1', 'RHOD', 'RHOJ', 'RPS27A', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'UHMK1', 'WWP2'], 'Affinity Capture-MS': ['ALDH4A1', 'BACH1', 'E6', 'FANCD2', 'NSP16AB', 'OTUB1', 'PAXIP1', 'RUNX1'], 'Affinity Capture-Western': ['COL1A1', 'COL3A1', 'COL5A1', 'DOK1', 'E6', 'E7', 'GATA4', 'HCVGP1', 'KAP-ALPHA3', 'KLF4', 'LEF1', 'MED', 'MED15', 'MEF2A', 'RNF111', 'SKI', 'SMAD2', 'SMAD4', 'SMOX', 'SNOO', 'UBX', 'VIS', 'WWTR1', 'YAP1'], 'Co-localization': ['E7', 'EZH2-A', 'KLF4'], 'PCA': ['E6', 'SMOX'], 'Phenotypic Enhancement': ['BABO', 'INR', 'SMOX', 'YKI'], 'Phenotypic Suppression': ['BABO', 'HPO', 'INR', 'MYO', 'PLUM', 'PTEN', 'SCGDELTA', 'SMOX'], 'Reconstituted Complex': ['E7', 'LEMD3', 'SMAD2', 'SOX9', 'UBX', 'ZFP128'], 'Two-hybrid': ['CG18095', 'D', 'E6', 'EG', 'FOXH1', 'HOXA13', 'HOXD13', 'HR78', 'SMAD2', 'SMOX', 'UBX', 'ZEB2', 'ZEN']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id='P84022', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'], diseases=['Colorectal cancer', 'Loeys-Dietz syndrome 3'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['BAG3', 'HIF1A', 'SMAD2', 'SMAD4', 'SMURF1', 'SMURF2', 'SP1'], 'Affinity Capture-MS': ['ARID1A', 'ATG14', 'ATG16L1', 'ATXN2L', 'BUB3', 'C1ORF116', 'CD6', 'CDK11A', 'CHD8', 'CIC', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DCAF4', 'DCAF7', 'DDX3X', 'DDX3Y', 'DDX4', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'DZIP3', 'EPB41L5', 'ERBB2IP', 'EVA1B', 'EZH2', 'FAM83G', 'FURIN', 'HINT3', 'HSPA4', 'IRF7', 'IRS1', 'ITGB4', 'KAT6A', 'KCTD16', 'LACRT', 'LDLRAD4', 'LEMD3', 'LRCH1', 'LSR', 'MAP2K3', 'MAPK1', 'MED16', 'MED4', 'NCOA3', 'NF2', 'OPA1', 'OTUB1', 'OTUD1', 'PABPC1', 'PARK2', 'PJA1', 'PLEKHA4', 'PPIE', 'PRNP', 'PSPC1', 'PTPN6', 'RAB11FIP5', 'RPL3', 'RPL4', 'RPSAP15', 'SIK3', 'SLC25A12', 'SLC9A3R2', 'SMAD1', 'SMAD2', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMURF2', 'SNW1', 'SQRDL', 'SUZ12', 'TAF1', 'TAF2', 'TCP1', 'TGFB1', 'TMEM192', 'TRIM33', 'TRIM67', 'TRIP4', 'U2AF2', 'UGT1A10', 'USP33', 'USP7', 'VAV2', 'WWP2', 'YTHDF2', 'YY1', 'ZFP69B', 'ZFYVE9', 'ZRANB1'], 'Affinity Capture-RNA': ['DDX58', 'TRIM25'], 'Affinity Capture-Western': ['ACTB', 'ACVR1B', 'AKT1', 'ANAPC10', 'AR', 'ATF2', 'ATF3', 'BACH1', 'BRCA1', 'BRCA2', 'BTRC', 'CBL', 'CDC16', 'CDC25A', 'CDC27', 'CDKN1A', 'CEBPD', 'CHRD', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CSNK1G2', 'CTCF', 'CTNNB1', 'CUL1', 'DAB2', 'DACH1', 'DEDD', 'DOCK9', 'E2F4', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXL2', 'FOXM1', 'FOXO1', 'FOXO3', 'FOXO4', 'GRIP1', 'GSK3B', 'HDAC4', 'HDAC5', 'HGS', 'HIF1A', 'HNF4A', 'HYAL2', 'ID1', 'IRF7', 'JUN', 'KAT2A', 'KAT2B', 'KAT6A', 'KDM5C', 'KDM6B', 'KLF5', 'KPNB1', 'LEF1', 'MAFK', 'MECOM', 'MED15', 'MED24', 'MED6', 'MEN1', 'METTL14', 'METTL3', 'MKL1', 'MYC', 'MYD88', 'MYOCD', 'NCOA1', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIC', 'NFYC', 'NOTCH1', 'NOTCH4', 'NR3C1', 'NR4A1', 'NUP214', 'OTUB1', 'OTUD1', 'OVOL2', 'PAX6', 'PCK2', 'PDLIM5', 'PIAS3', 'PIAS4', 'PIN1', 'PITX1', 'PITX2', 'PML', 'PPARG', 'PPP1R12C', 'PRDM16', 'PRTN3', 'RARA', 'RBBP5', 'RBL1', 'RBX1', 'RELB', 'RGCC', 'RNF111', 'RNF31', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SETD2', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD7', 'SMARCA4', 'SMARCC2', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'SQSTM1', 'SREBF2', 'SRY', 'STRAP', 'STUB1', 'SUV39H1', 'TCF12', 'TGFB1I1', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TGIF2', 'TOB1', 'TP53', 'TRIB3', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'TSC22D4', 'UCHL1', 'UCHL5', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWOX', 'WWP1', 'WWP2', 'YAP1', 'ZC3H12A', 'ZEB1', 'ZEB2', 'ZFYVE9', 'ZMIZ1'], 'Biochemical Activity': ['CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'CSNK1G2', 'MAPK1', 'NEDD4', 'NEDD4L', 'OTUB1', 'TGFBR1', 'USP15', 'USP7', 'WWP2'], 'Co-crystal Structure': ['SMAD3', 'SMAD4', 'ZFYVE9'], 'Co-fractionation': ['ALKBH2', 'ANAPC10', 'APP', 'ARID1B', 'CDH1', 'CREBBP', 'CTCF', 'CTNNB1', 'CUL1', 'DDR1', 'FOXO3', 'HDAC1', 'HMGA2', 'IGF1R', 'ITGB1', 'JUND', 'MTA2', 'NAA15', 'NT5DC3', 'PARP1', 'PRKDC', 'RBM14', 'RBX1', 'RELA', 'RIPK1', 'RNMT', 'SIN3A', 'SKP1', 'SMAD2', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SP1', 'SUB1', 'TRIM33', 'XRCC5', 'XRCC6', 'ZFHX3', 'ZFYVE9'], 'Co-localization': ['AKT1', 'BMP7', 'CAMK2G', 'CDK2', 'CDK4', 'EPAS1', 'ETS1', 'FOXO3', 'HIF1A', 'IRF7', 'MAP3K7', 'MAPK8', 'MAX', 'TP53', 'TRIM62'], 'Cross-Linking-MS (XL-MS)': ['RPL10A'], 'FRET': ['SMAD4', 'STUB1'], 'PCA': ['SMAD4', 'SMAD7'], 'Phenotypic Enhancement': ['HIF1A', 'SMAD2', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['JAK1'], 'Protein-RNA': ['LINC00941'], 'Protein-peptide': ['CREBBP', 'FOXH1', 'ITCH', 'LEF1', 'NEDD4', 'PIN1'], 'Proximity Label-MS': ['NFIA'], 'Reconstituted Complex': ['ANAPC10', 'APP', 'AR', 'ATF2', 'ATF3', 'BPTF', 'BRCA1', 'BRCA2', 'CEBPA', 'CEBPB', 'CEBPD', 'CITED2', 'CREBBP', 'CTCF', 'DAB2', 'DDX5', 'DEDD', 'DNMT3L', 'DVL1', 'E2F4', 'EID2', 'EIF4B', 'EP300', 'ERBB2IP', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXM1', 'GSK3B', 'HDAC1', 'HDAC4', 'HDAC5', 'HIF1A', 'HIPK2', 'HNF4A', 'HYAL2', 'IRF7', 'ITCH', 'JUN', 'JUNB', 'JUND', 'KAT2B', 'KAT6A', 'KPNB1', 'LCK', 'LEF1', 'LEMD3', 'MAX', 'MDM4', 'MECOM', 'MYC', 'MYOCD', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIA', 'NOTCH1', 'NR3C1', 'NUP153', 'NUP214', 'PARD3', 'PIAS2', 'PIAS3', 'PIAS4', 'PIK3CA', 'PIN1', 'RBL1', 'RUNX2', 'S100A4', 'SH2D2A', 'SIN3A', 'SKI', 'SKIL', 'SMAD3', 'SMAD4', 'SMURF2', 'SNW1', 'SP1', 'STUB1', 'TFE3', 'TGFB1I1', 'TGFBR1', 'TGIF1', 'TP53', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'UCHL5', 'USP15', 'VDR', 'WWOX', 'XPO6', 'YY1', 'ZFYVE9', 'ZMIZ1'], 'Two-hybrid': ['AATF', 'AES', 'ANK3', 'APMAP', 'APOB', 'AR', 'ATF2', 'BLZF1', 'C10ORF54', 'C14ORF105', 'CCDC33', 'CDC25A', 'CFDP1', 'CFH', 'CFLAR', 'CHRD', 'CORO1A', 'CPSF7', 'CPTP', 'CREBBP', 'CRX', 'CSH2', 'CXXC5', 'CYP11A1', 'DEDD', 'DNAJB4', 'DNAJB5', 'EBI3', 'EP300', 'EPAS1', 'FAM90A1', 'FBLN1', 'FLI1', 'FLNA', 'FOS', 'FOXH1', 'GGA1', 'GIT2', 'GMEB1', 'HDAC1', 'HEY1', 'HEYL', 'HIF1A', 'HIVEP1', 'HNRNPK', 'HOXC11', 'HP', 'ISL1', 'JUN', 'JUNB', 'KANSL1', 'KDM2A', 'KMT2B', 'LBP', 'MCM3AP', 'MEOX2', 'MTF2', 'MYC', 'MYD88', 'NCOA6', 'NEDD4', 'NEDD9', 'NR4A1', 'PAPPA', 'PARP4', 'PCDH1', 'PCK2', 'PHC2', 'PIAS4', 'PIN1', 'PLAG1', 'PLAGL1', 'PLG', 'PPP1R12C', 'PPP2R1A', 'PRDM4', 'PROX1', 'PSMB1', 'PSMD11', 'RANBP9', 'RBPMS', 'RBX1', 'RCVRN', 'RELA', 'RIOK2', 'RNF31', 'RPA1', 'RPLP0', 'SAP130', 'SBK3', 'SERTAD1', 'SETD2', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMURF1', 'SMURF2', 'SNRNP70', 'SNW1', 'SP1', 'SQSTM1', 'SS18L1', 'ST6GALNAC2', 'SVEP1', 'TANK', 'TDP2', 'TEKT4', 'TF', 'TGM2', 'TLR4', 'TMED1', 'TSC22D4', 'UBQLN4', 'USP7', 'VDR', 'WWP1', 'WWP2', 'XRCC6', 'ZBTB16', 'ZBTB3', 'ZC3H12A', 'ZCCHC14', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF329', 'ZNF774', 'ZNF83']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF6', 'ARHGEF7', 'CLASRP', 'FBXO3', 'GSC', 'MAP2K3', 'PPP2R2D', 'RAB38', 'RASD2', 'RGS3', 'RRAS2', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'WEE1', 'WWP2'], 'Affinity Capture-MS': ['ATG16L1', 'E6', 'NSP6', 'OTUB1', 'SMAD3'], 'Affinity Capture-Western': ['AXIN1', 'COL1A1', 'COL3A1', 'COL5A1', 'DDX5', 'DOK1', 'E6', 'E7', 'EP300', 'GATA4', 'GNB2L1', 'HCVGP1', 'HDAC4', 'KLF4', 'MED15', 'MELK', 'N', 'RNF111', 'SKI', 'SMAD3', 'SMAD3A', 'SMAD4', 'TGFB1I1', 'TOB1', 'TOB1A', 'TOB1B', 'VDR', 'ZEB1'], 'Co-localization': ['E7', 'N'], 'PCA': ['E6'], 'Phenotypic Enhancement': ['SMAD3A'], 'Phenotypic Suppression': ['SMAD3A'], 'Proximity Label-MS': ['M'], 'Reconstituted Complex': ['E6', 'E7', 'GATA4', 'N', 'SIN3A', 'SMAD3', 'SOX9', 'YAP1', 'ZFP128'], 'Synthetic Growth Defect': ['MMP9'], 'Two-hybrid': ['DVL1', 'E6', 'ERBB2IP', 'FOXH1', 'GATA4', 'HCVGP1', 'JUN', 'MAGI2', 'PARD3', 'SMAD3', 'ZEB2']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=[], tissue_specific_expression={}, is_essential=False, genetic_constraint={}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID'])}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 2, 'used_tools': ['BioGRID', 'MSigDB', 'chembl', 'drug_central', 'extract_entities', 'prot', 'uniprot_base'], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID', 'OpenTargets', 'reactome', 'humanbase_functions', 'Summarize_GO'], 'ui': {}, 'prot_html': '\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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    \\\\n\\\\n\\\\n', 'drug_central_html': '', 'aa_seq_html': '', 'text_notes': []}\\n[TOOL RUN] → OpenTargets\\nFailed to pull pharmacovigilance: Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id='Q15796', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma'], diseases=['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['SMAD3', 'SMAD4', 'SMURF2'], 'Affinity Capture-MS': ['ARID1A', 'ARID1B', 'ASH2L', 'ATAD3B', 'BCL7A', 'BTBD9', 'BUB3', 'C1ORF116', 'CAD', 'CCT6A', 'CDC27', 'CGA', 'CPSF7', 'CREBBP', 'CSNK1D', 'CTNNB1', 'CUL4A', 'CUL4B', 'DCAF7', 'DDX3Y', 'DGKA', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'EPB41L5', 'ERBB2IP', 'EZH2', 'FAM83G', 'FLOT1', 'FLOT2', 'FYN', 'GSK3A', 'GTF3C2', 'GTF3C6', 'HCFC1', 'HDAC2', 'HDAC4', 'HINT3', 'HSPA4', 'ITGB4', 'KLF5', 'KMT2C', 'LDLRAD4', 'LEMD3', 'MED15', 'MED16', 'MED17', 'MED19', 'MED20', 'MED22', 'MED25', 'MED31', 'MED4', 'MED9', 'MEN1', 'MTMR4', 'NCOA3', 'OGT', 'OPA1', 'OTUB1', 'PARK2', 'PCBP1', 'PCID2', 'PLEKHA4', 'PSPC1', 'RIN1', 'SGSH', 'SIK3', 'SKI', 'SKIL', 'SLC25A3', 'SLC25A5', 'SLC25A6', 'SMAD1', 'SMAD3', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMARCD2', 'SMPDL3B', 'SMURF2', 'SNW1', 'SNX27', 'SQRDL', 'TAF1', 'TAF2', 'TAF3', 'TAF5', 'TAF6', 'TMED8', 'TMOD1', 'TRIM28', 'TRIM33', 'TRIM67', 'U2AF2', 'WDR82', 'WRNIP1', 'WWP2', 'YAF2', 'YY1', 'ZFYVE9'], 'Affinity Capture-RNA': ['DDX58', 'ELAVL1'], 'Affinity Capture-Western': ['ACVR1B', 'ACVR2B', 'AKT1', 'ANAPC10', 'ATF3', 'BRCA2', 'CDC16', 'CDC27', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DAB2', 'DOCK9', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'ETV4', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'FOXP1', 'GLI1', 'GTF2I', 'GTF2IRD1', 'HDAC1', 'HGS', 'HYAL2', 'ING2', 'INSR', 'IRF3', 'IRF7', 'ITCH', 'JUN', 'KAT2A', 'KAT2B', 'KDM6B', 'KLF5', 'LEF1', 'MAPT', 'MED15', 'MED24', 'MED6', 'MEF2A', 'METTL14', 'METTL3', 'MYC', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFYC', 'NOTCH4', 'NUP214', 'OTUB1', 'OVOL2', 'PIAS3', 'PIAS4', 'PIN1', 'PML', 'PRDM16', 'RBBP5', 'RELB', 'RGCC', 'RNF111', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD6', 'SMAD7', 'SMARCA4', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'STRAP', 'TCF12', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TP53', 'TRIM28', 'TRIM33', 'TSC2', 'UCHL1', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWP1', 'WWP2', 'YAP1', 'ZEB1', 'ZFYVE9'], 'Biochemical Activity': ['ACVR1B', 'CAMK2G', 'CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'ITCH', 'TGFBR1'], 'Co-crystal Structure': ['SMAD4'], 'Co-fractionation': ['AP1M1', 'ARID1B', 'CAV1', 'CREBBP', 'CTNNB1', 'HDAC1', 'HMGA2', 'MTA2', 'NAA15', 'NCOA3', 'PARP1', 'PML', 'PRKDC', 'RBM14', 'RELA', 'SMAD3', 'SMAD4', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SUB1', 'TGFBR1', 'TRIM33', 'XRCC6', 'ZFYVE9'], 'Co-localization': ['CAMK2A', 'TGFBR1', 'TP53'], 'FRET': ['BECN1', 'LATS2', 'MYC', 'SMAD1'], 'Phenotypic Enhancement': ['SMAD3', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['SPPL3'], 'Proximity Label-MS': ['CCNF', 'EPHA2', 'OPTN', 'RAB7A', 'SNCA', 'TGOLN2'], 'Reconstituted Complex': ['ANAPC10', 'ANP32B', 'ANP32E', 'ATP5I', 'BPTF', 'CREBBP', 'DAB2', 'DVL1', 'ELAC2', 'ERBB2IP', 'ESR1', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'HDAC2', 'HIPK2', 'HYAL2', 'INSR', 'IRF7', 'JUN', 'KAT2B', 'LCK', 'LEF1', 'MECOM', 'MEF2A', 'MEF2C', 'MYC', 'MYOCD', 'NEDD4L', 'NEFM', 'NFIA', 'NUP214', 'OTUB1', 'PARD3', 'PIAS3', 'PIK3CA', 'PIN1', 'PTMS', 'RHOA', 'SH2D2A', 'SKI', 'SMAD4', 'SMAD7', 'SMURF2', 'SNW1', 'SOD1', 'SP1', 'STUB1', 'SYT1', 'TP53', 'TUBA1B', 'UCHL5', 'YY1', 'ZFYVE9'], 'Two-hybrid': ['ABTB1', 'AKT1', 'ANAPC2', 'ANK3', 'ANTXR2', 'BAZ1A', 'BTBD2', 'C22ORF46', 'C9ORF156', 'CISH', 'COPS5', 'CORO2A', 'CREBBP', 'CSH1', 'CSH2', 'CUL5', 'CYLC2', 'CYP11A1', 'DCUN1D1', 'DNAJB5', 'DNAJC7', 'DOCK8', 'DYNC1H1', 'DYRK1A', 'EEF1A1', 'EIF3L', 'EP300', 'ETV4', 'FAM161B', 'FBP2', 'FOXH1', 'GATAD2B', 'GFER', 'HSD17B3', 'INSR', 'KHDRBS1', 'KIAA1033', 'KPNB1', 'LAMA5', 'LEMD3', 'MAP2K1', 'MLLT4', 'MYC', 'NAGK', 'NCOA6', 'NEDD4L', 'OS9', 'PAPOLA', 'PAPPA', 'PAXIP1', 'PEX19', 'PIAS4', 'PLIN3', 'POU2AF1', 'PPP2R1A', 'PRKAR1A', 'PSAP', 'PSG9', 'PSMD11', 'PSMD8', 'RANBP6', 'RANBP9', 'RARB', 'RASA1', 'RNF123', 'RNPC3', 'ROCK1', 'RPS14', 'RPS27A', 'RXRA', 'SKI', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD9', 'SMURF1', 'SMURF2', 'SNAPIN', 'SNIP1', 'SNRNP70', 'SNW1', 'SP1', 'SRI', 'ST13', 'ST5', 'TBC1D1', 'TGIF1', 'TGM2', 'TRIM62', 'UBA52', 'UBR5', 'XPA', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF41', 'ZNF510', 'ZNHIT6']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF1', 'ARHGEF6', 'ARHGEF7', 'ARL4D', 'CDC40', 'FBXO3', 'IRAK2', 'LHX9', 'LMO2', 'MAP2K3', 'NUAK2', 'PPP2R2D', 'RAB34', 'RAB38', 'RASD2', 'RGS3', 'RHEBL1', 'RHOBTB1', 'RHOD', 'RHOJ', 'RPS27A', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'UHMK1', 'WWP2'], 'Affinity Capture-MS': ['ALDH4A1', 'BACH1', 'E6', 'FANCD2', 'NSP16AB', 'OTUB1', 'PAXIP1', 'RUNX1'], 'Affinity Capture-Western': ['COL1A1', 'COL3A1', 'COL5A1', 'DOK1', 'E6', 'E7', 'GATA4', 'HCVGP1', 'KAP-ALPHA3', 'KLF4', 'LEF1', 'MED', 'MED15', 'MEF2A', 'RNF111', 'SKI', 'SMAD2', 'SMAD4', 'SMOX', 'SNOO', 'UBX', 'VIS', 'WWTR1', 'YAP1'], 'Co-localization': ['E7', 'EZH2-A', 'KLF4'], 'PCA': ['E6', 'SMOX'], 'Phenotypic Enhancement': ['BABO', 'INR', 'SMOX', 'YKI'], 'Phenotypic Suppression': ['BABO', 'HPO', 'INR', 'MYO', 'PLUM', 'PTEN', 'SCGDELTA', 'SMOX'], 'Reconstituted Complex': ['E7', 'LEMD3', 'SMAD2', 'SOX9', 'UBX', 'ZFP128'], 'Two-hybrid': ['CG18095', 'D', 'E6', 'EG', 'FOXH1', 'HOXA13', 'HOXD13', 'HR78', 'SMAD2', 'SMOX', 'UBX', 'ZEB2', 'ZEN']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Overgrowth', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Myocardial fibrosis', 'Increased total eosinophil count', 'Thrombocytosis', 'Anemia', 'Acute kidney injury', 'Glucose intolerance', 'Pulmonary hypoplasia', 'Pneumonia', 'Asthma', 'Ischemic stroke', 'Cerebral ischemia', 'Vascular dilatation', 'Aortic dissection', 'Systemic lupus erythematosus', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Skeletal muscle atrophy', 'Muscular dystrophy', 'Cachexia', 'Thrombophlebitis', 'Miscarriage', 'Ureteral obstruction', 'Airway obstruction', 'Amyotrophic lateral sclerosis', 'Peripheral demyelination', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Reduced sperm motility', 'Urethral stricture', 'Renal atrophy', 'Cervical polyp', 'Shock', 'Granuloma', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Sepsis', 'geleophysic dysplasia', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'hydronephrosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'renal cell adenocarcinoma', 'Autoimmune Hepatitis', 'neurodegenerative disease', 'brain disease', 'aortic disease', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'head and neck neoplasia', 'breast ductal adenocarcinoma', 'laryngeal squamous cell carcinoma', 'ovarian adenocarcinoma', 'ovarian mucinous adenocarcinoma', 'ovarian teratoma', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'dysplastic oral keratinocyte', 'undifferentiated carcinoma', 'cerebral amyloid angiopathy', 'head and neck malignant neoplasia', 'breastfeeding duration', 'urgency urinary incontinence', 'fibrosis', 'Balkan nephropathy', 'congenital rubella', 'echinococcosis', 'Gerstmann syndrome', 'inclusion body myositis', 'muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10', 'severe neurodegenerative syndrome with lipodystrophy', 'Diamond-Blackfan anemia', 'cardiofaciocutaneous syndrome', 'adrenomyeloneuropathy', 'hereditary sensory and autonomic neuropathy', 'nasopharyngeal carcinoma', 'keratoconus', 'dentin dysplasia', 'T-cell non-Hodgkin lymphoma', 'dyskeratosis congenita', 'pneumoconiosis', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'cryopyrin-associated periodic syndrome', 'holoprosencephaly', 'pachyonychia congenita', 'familial rhabdoid tumor', 'familial hyperaldosteronism', 'primary ciliary dyskinesia', 'meningioma', 'pilocytic astrocytoma', 'hemangioblastoma', 'microcephaly-brain defect-spasticity-hypernatremia syndrome', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'heritable pulmonary arterial hypertension', 'juvenile polyposis syndrome', 'congenital herpes simplex virus infection', 'popliteal pterygium syndrome', 'ameloblastoma', 'hypersensitivity pneumonitis', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'emphysema', 'epilepsy', 'esophageal adenocarcinoma', 'fetal growth restriction', 'follicular thyroid adenoma', 'ganglioneuroma', 'follicular thyroid carcinoma', 'gastric adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'genetic disorder', 'germ cell tumor', 'glioblastoma multiforme', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'large cell neuroendocrine carcinoma', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'neural tube defect', 'tuberculosis', 'glioblastoma', 'carcinoma of liver and intrahepatic biliary tract', 'hereditary nonpolyposis colon cancer', 'Zika virus infectious disease', 'left ventricular noncompaction', 'multiminicore myopathy', 'Loeys-Dietz syndrome', 'neurofibromatosis type 1', 'Leber congenital amaurosis', 'osteogenesis imperfecta', 'progressive supranuclear palsy', 'intrahepatic cholestasis', 'lymphedema', 'posterior cortical atrophy', 'follicular lymphoma', 'kidney Wilms tumor', 'bronchopulmonary dysplasia', 'sarcoidosis', 'peeling skin syndrome', 'lissencephaly with cerebellar hypoplasia', 'aggressive NK-cell leukemia', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'familial thoracic aortic aneurysm and aortic dissection', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'precursor B-cell acute lymphoblastic leukemia', 'superficial spreading melanoma', 'lung neoplasm', 'intestinal neoplasm', 'odontogenic neoplasm', 'disorder of ear', 'endometrium neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'carcinoma of pharynx', 'polyp of colon', 'low grade glioma', 'corticobasal degeneration disorder', 'cervical intraepithelial neoplasia', 'viral myocarditis', 'lip and oral cavity carcinoma', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'chondrogenic neoplasm', 'intraepithelial neoplasia', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'pulmonary sarcoidosis', 'gonorrhea', 'B-cell acute lymphoblastic leukemia', 'chronic lymphocytic leukemia', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'myelodysplastic syndrome', 'oral squamous cell carcinoma', 'gastritis', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'acute promyelocytic leukemia', 'adenocarcinoma', 'adenoma', 'age', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', \\\"Barrett's esophagus\\\", 'benign prostatic hyperplasia', 'bladder tumor', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'central nervous system cancer', 'chondrosarcoma', 'chromophobe renal cell carcinoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'clear cell renal carcinoma', 'endometrial carcinoma', 'ovarian serous carcinoma', 'renal fibrosis', 'Abruptio Placentae', 'Adenomyosis', 'Carcinoma, Lewis Lung', 'chronic myelomonocytic leukemia', 'Marchiafava-Bignami Disease', 'oral submucous fibrosis', 'osteoradionecrosis', 'renal nutcracker syndrome', 'amyloidosis', 'mucositis', 'neuroendocrine neoplasm', 'neuromuscular disease', 'oral mucositis', 'Spinal cord injury', 'cutaneous squamous cell carcinoma', 'Barrett adenocarcinoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'pharyngeal squamous cell carcinoma', 'soft tissue sarcoma', 'undifferentiated pleomorphic sarcoma', 'connective tissue disease', 'pneumonitis', 'intrahepatic cholangiocarcinoma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'glomerular disease', 'nephritis', 'Neurogenic bladder', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Uterine leiomyoma', 'Cleft palate', 'Hydrocephalus', 'Cataract', 'Myopia', 'Autism', 'Infertility', 'Diabetes mellitus', 'Insulin resistance', 'Osteoporosis', 'Hyperkeratosis', 'Intellectual disability', 'Ataxia', 'Mental deterioration', 'Stroke', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Hepatic steatosis', 'Obesity', 'mixed connective tissue disease', 'pneumocystosis', 'pseudomyxoma peritonei', 'silicosis', 'toxoplasmosis', 'hemoglobin A1 measurement', 'BMI-adjusted waist-hip ratio', 'liver dysplastic nodule', 'gut microbiome measurement', 'platelet crit', 'allergen exposure measurement', 'calf circumference measurement', 'dysplasia', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'digestive system neoplasm', 'Hepatobiliary Neoplasm', 'American trypanosomiasis', 'acute myocardial infarction', 'pemphigus foliaceus', 'cystic kidney disease', 'Polycystic Kidney Disease', 'arteriosclerosis', 'hyperuricemia', 'skin carcinoma', 'heel bone mineral density', 'pulmonary fibrosis', 'hyperaldosteronism', 'gastric ulcer', 'infarction', 'aortic valve disease', 'heart valve disease', 'mitral valve disease', 'urinary tract obstruction', 'prostate disease', 'stomach disease', 'myocarditis', 'aneurysm', 'enthesopathy', 'musculoskeletal system disease', 'metastasis', 'Gallbladder Adenocarcinoma', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Malignant Mesothelioma', 'Malignant Pancreatic Neoplasm', 'Medullomyoblastoma with Myogenic Differentiation', 'Microcystic Meningioma', 'Mixed Tumor of the Salivary Gland', 'Nasal Cavity Polyp', 'Osteoblastoma', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Paraganglioma', 'Placental Choriocarcinoma', 'Rectal Tubular Adenoma', 'Sarcomatoid Carcinoma', 'Signet Ring Cell Gastric Adenocarcinoma', 'Synovial Chondromatosis', 'Testicular Non-Seminomatous Germ Cell Tumor', 'Testicular Yolk Sac Tumor', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vulvar Squamous Cell Carcinoma', 'acute respiratory distress syndrome', 'sarcopenia', 'rectum cancer', 'acanthosis nigricans', 'mucous membrane pemphigoid', 'punctate palmoplantar keratoderma type III', 'adrenal cortex carcinoma', 'alcoholic liver cirrhosis', 'atrophic gastritis', 'dental fluorosis', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'multiple system atrophy', 'myeloid sarcoma', 'nodular goiter', 'periapical granuloma', 'pulmonary edema', 'renovascular hypertension', 'retinopathy of prematurity', 'rheumatic heart disease', 'thromboangiitis obliterans', 'tooth disease', 'uremia', 'non-alcoholic steatohepatitis', 'Cryptogenic Organizing Pneumonia', 'Fascioliasis', 'Follicular Cyst', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Myocardial Ischemia', 'Pelvic Inflammatory Disease', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Pneumonia, Aspiration', 'Respiratory Syncytial Virus Infection', 'diabetic cardiomyopathy', 'diabetic foot', 'endothelial dysfunction', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'schistosomiasis', 'abortion', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'Bartsocas-Papas syndrome 1', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'SHOX-related short stature', 'intellectual disability, X-linked syndromic, Turner type', 'Fabry disease', 'X-linked corneal dermoid', 'Aarskog-Scott syndrome, X-linked', 'holoprosencephaly-hypokinesia-congenital contractures syndrome', 'Melnick-Needles syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'Wilson disease', 'adenomyosis', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'Ehlers-Danlos syndrome, musculocontractural type', 'tetrasomy 12p', 'sickle cell anemia', 'hypotonia-cystinuria syndrome', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'autoimmune lymphoproliferative syndrome type 2B', 'endometrial cancer', 'Loeys-Dietz syndrome 1', 'hyperinsulinemic hypoglycemia, familial, 4', 'preterm premature rupture of the membranes', 'Mungan syndrome', 'Crouzon syndrome-acanthosis nigricans syndrome', 'papillary renal cell carcinoma', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'pterygium', 'renal cell carcinoma', 'rheumatoid arthritis', 'sarcoma', 'severe acute respiratory syndrome', 'small cell lung carcinoma', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'spondyloarthropathy', 'stroke', 'subarachnoid hemorrhage', 'systemic scleroderma', 'ulcerative colitis', 'melanoma', 'hepatocellular adenoma', 'viral disease', 'HIV infection', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'pneumococcal infection', 'temporal lobe epilepsy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'malaria', 'folate deficiency', 'lung carcinoma', 'ovarian carcinoma', 'familial amyotrophic lateral sclerosis', 'pulmonary arterial hypertension', 'age-related macular degeneration', 'synovial sarcoma', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'villous adenoma', 'mucosal melanoma', 'ovarian clear cell cancer', 'central nervous system primitive neuroectodermal neoplasm', 'Crohn ileitis', 'vertebral column disorder', 'endometrial disorder', 'gastric cancer', 'penile cancer', 'myopia', 'pulmonary alveolar proteinosis', 'Chagas disease', 'leiomyoma', 'brain cancer', 'tuberous sclerosis', 'sick sinus syndrome', 'arteriovenous hemangioma/malformation', 'hypertensive heart disease', 'head and neck carcinoma', 'depressive disorder', 'pneumothorax', 'Richter syndrome', 'peritoneum cancer', 'thyroid cancer', 'disorder of sexual differentiation', 'vulvar melanoma', 'papilloma', 'rectosigmoid junction neoplasm', 'Treacher-Collins syndrome', 'prostatic acinar adenocarcinoma', 'gingival overgrowth', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratoma', 'bone inflammation disease', 'extraosseous osteosarcoma', 'chondroblastic osteosarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'lung benign neoplasm', 'skin cancer', 'cervical cancer', 'seminoma', 'breast angiosarcoma', 'cerebellar pilocytic astrocytoma', 'salivary gland adenoid cystic carcinoma', 'bile duct adenocarcinoma', 'gastroesophageal junction adenocarcinoma', 'thoracic cancer', 'acral lentiginous melanoma', 'endometrial mixed adenocarcinoma', 'female breast carcinoma', 'inflammation', 'erythrocyte volume', 'glomerular filtration rate', 'bone tissue density', 'progesterone amount', 'serum alanine aminotransferase amount', 'serum urea amount', 'serum creatinine amount', 'body height', 'cyst', 'Hypotonia - cystinuria syndrome', 'Chédiak-Higashi syndrome', 'Åland Islands eye disease', 'Hydrocephalus with stenosis of the aqueduct of Sylvius', 'Autoimmune lymphoproliferative syndrome with recurrent viral infections', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Persistent Müllerian duct syndrome', 'WHIM syndrome', 'Familial adenomatous polyposis', 'Other metabolic disease', 'hematocrit', 'C-reactive protein measurement', 'hematological measurement', 'alkaline phosphatase measurement', 'cryptorchidism', 'lymphocyte count', 'gestational diabetes', 'acute lung injury', 'serum gamma-glutamyl transferase measurement', 'HbA1c measurement', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'wet macular degeneration', 'insomnia', 'hypothyroidism', 'pelvic organ prolapse', 'metabolite measurement', 'eosinophil count', 'lymph node metastatic carcinoma', 'embryonal carcinoma', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'monocyte count', 'autoimmune disease', 'congenital heart disease', 'cholangiocarcinoma', 'human african trypanosomiasis', 'reading', 'congenital heart malformation', 'temporomandibular joint disorder', 'axial length measurement', 'myeloid leukemia', 'lupus erythematosus', 'allergic asthma', 'fatty liver disease', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'cataract', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'multiple sclerosis', 'skin basal cell carcinoma', 'brain glioma', 'colorectal cancer', 'Wilms tumor', 'Townes-Brocks syndrome', 'nevoid basal cell carcinoma syndrome', 'breast cancer', 'congenital contractural arachnodactyly', 'Duane retraction syndrome', 'dyschromatosis symmetrica hereditaria', 'metastatic malignant neoplasm', 'Loeys-Dietz syndrome 6', 'cervical squamous intraepithelial neoplasia', 'leukoplakia', 'spinal cord injury', 'ulcer disease', 'desmoplastic melanoma', 'myelofibrosis', 'oral cavity carcinoma', 'rectal carcinoma', 'hydrocephalus, congenital, 3, with brain anomalies', 'nasal cavity and paranasal sinus carcinoma', 'COVID-19', 'Dravet syndrome', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'achalasia-alacrima syndrome', 'metabolic bone disorder', 'congenital heart defects, multiple types, 8, with or without heterotaxy', 'postmenopausal osteoporosis', 'intestinal polyp', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'breast neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'stomach neoplasm', 'ankylosing spondylitis', 'ciliopathy', 'deep vein thrombosis', 'obstructive sleep apnea', 'necrotizing enterocolitis', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'atherosclerosis', 'open-angle glaucoma', 'androgenetic alopecia', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'focal segmental glomerulosclerosis', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'myeloproliferative disorder', 'nephrotic syndrome', 'vascular disease', 'thoracic aortic aneurysm', 'venous thromboembolism', 'platelet count', 'body mass index', 'neuroimaging measurement', 'metastatic neoplasm', 'whole body water mass', 'kidney injury', 'bone metastasis', 'gastrointestinal disease', 'aspartate aminotransferase to alanine aminotransferase ratio', 'urea measurement', 'viral load', '2-hydroxyacetaminophen sulfate measurement', 'aging', 'serum lipopolysaccharide activity', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'ependymoma', 'granulosa cell tumor', 'metaplastic breast carcinoma', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'ACTH-Producing Pituitary Gland Adenoma', 'Adenomatoid Odontogenic Tumor', 'Ampulla of Vater Carcinoma', 'Anal Squamous Cell Carcinoma', 'Anaplastic (Malignant) Meningioma', 'Appendix Adenocarcinoma', 'Appendix Goblet Cell Carcinoid', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Breast Carcinoma by Gene Expression Profile', 'cervical squamous cell carcinoma', 'Columnar Cell Hyperplasia of the Breast', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Extramammary Paget Disease', 'fibrodysplasia ossificans progressiva', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'Pallister-Hall syndrome', 'Nager acrofacial dysostosis', 'Marfan syndrome', 'Cowden syndrome 1', 'nail-patella syndrome', 'ovarian cancer', 'Andersen-Tawil syndrome', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'nonpapillary renal cell carcinoma', 'Mobius syndrome', 'Peyronie disease', 'prostate cancer', 'retinoblastoma', 'acrodermatitis enteropathica', 'mitochondrial DNA depletion syndrome 4a', 'Alstrom syndrome', 'anencephaly 1', 'microphthalmia with limb anomalies', 'Bloom syndrome', 'lung cancer', 'cerebrotendinous xanthomatosis', 'cystic fibrosis', 'recessive dystrophic epidermolysis bullosa', 'Haim-Munk syndrome', 'Laurence-Moon syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'ischemic cardiomyopathy', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'fibrosarcoma', 'hypertrophy', 'actinic keratosis', 'anaplastic astrocytoma', 'anaplastic oligodendroglioma', 'cardiac hypertrophy', 'AIDS dementia', 'pancreatic carcinoma', 'prostate intraepithelial neoplasia', 'thyroid carcinoma', 'insulin resistance', 'esophageal carcinoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'acute megakaryoblastic leukaemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'pleomorphic liposarcoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'Pick disease', 'testicular seminoma', 'osteomyelitis', 'spina bifida', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'lung disease', 'dental caries', 'serous adenocarcinoma', 'retinopathy', 'adrenal gland neoplasm'], tissue_specific_expression={'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\"small intestine Peyer's patch\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}, is_essential=False, genetic_constraint={'syn': 0.11195000261068344, 'mis': 4.47730016708374, 'lof': 1.0}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID']), 'SMAD2'\\nFailed to pull pharmacovigilance: Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id='P84022', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'], diseases=['Colorectal cancer', 'Loeys-Dietz syndrome 3'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['BAG3', 'HIF1A', 'SMAD2', 'SMAD4', 'SMURF1', 'SMURF2', 'SP1'], 'Affinity Capture-MS': ['ARID1A', 'ATG14', 'ATG16L1', 'ATXN2L', 'BUB3', 'C1ORF116', 'CD6', 'CDK11A', 'CHD8', 'CIC', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DCAF4', 'DCAF7', 'DDX3X', 'DDX3Y', 'DDX4', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'DZIP3', 'EPB41L5', 'ERBB2IP', 'EVA1B', 'EZH2', 'FAM83G', 'FURIN', 'HINT3', 'HSPA4', 'IRF7', 'IRS1', 'ITGB4', 'KAT6A', 'KCTD16', 'LACRT', 'LDLRAD4', 'LEMD3', 'LRCH1', 'LSR', 'MAP2K3', 'MAPK1', 'MED16', 'MED4', 'NCOA3', 'NF2', 'OPA1', 'OTUB1', 'OTUD1', 'PABPC1', 'PARK2', 'PJA1', 'PLEKHA4', 'PPIE', 'PRNP', 'PSPC1', 'PTPN6', 'RAB11FIP5', 'RPL3', 'RPL4', 'RPSAP15', 'SIK3', 'SLC25A12', 'SLC9A3R2', 'SMAD1', 'SMAD2', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMURF2', 'SNW1', 'SQRDL', 'SUZ12', 'TAF1', 'TAF2', 'TCP1', 'TGFB1', 'TMEM192', 'TRIM33', 'TRIM67', 'TRIP4', 'U2AF2', 'UGT1A10', 'USP33', 'USP7', 'VAV2', 'WWP2', 'YTHDF2', 'YY1', 'ZFP69B', 'ZFYVE9', 'ZRANB1'], 'Affinity Capture-RNA': ['DDX58', 'TRIM25'], 'Affinity Capture-Western': ['ACTB', 'ACVR1B', 'AKT1', 'ANAPC10', 'AR', 'ATF2', 'ATF3', 'BACH1', 'BRCA1', 'BRCA2', 'BTRC', 'CBL', 'CDC16', 'CDC25A', 'CDC27', 'CDKN1A', 'CEBPD', 'CHRD', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CSNK1G2', 'CTCF', 'CTNNB1', 'CUL1', 'DAB2', 'DACH1', 'DEDD', 'DOCK9', 'E2F4', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXL2', 'FOXM1', 'FOXO1', 'FOXO3', 'FOXO4', 'GRIP1', 'GSK3B', 'HDAC4', 'HDAC5', 'HGS', 'HIF1A', 'HNF4A', 'HYAL2', 'ID1', 'IRF7', 'JUN', 'KAT2A', 'KAT2B', 'KAT6A', 'KDM5C', 'KDM6B', 'KLF5', 'KPNB1', 'LEF1', 'MAFK', 'MECOM', 'MED15', 'MED24', 'MED6', 'MEN1', 'METTL14', 'METTL3', 'MKL1', 'MYC', 'MYD88', 'MYOCD', 'NCOA1', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIC', 'NFYC', 'NOTCH1', 'NOTCH4', 'NR3C1', 'NR4A1', 'NUP214', 'OTUB1', 'OTUD1', 'OVOL2', 'PAX6', 'PCK2', 'PDLIM5', 'PIAS3', 'PIAS4', 'PIN1', 'PITX1', 'PITX2', 'PML', 'PPARG', 'PPP1R12C', 'PRDM16', 'PRTN3', 'RARA', 'RBBP5', 'RBL1', 'RBX1', 'RELB', 'RGCC', 'RNF111', 'RNF31', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SETD2', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD7', 'SMARCA4', 'SMARCC2', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'SQSTM1', 'SREBF2', 'SRY', 'STRAP', 'STUB1', 'SUV39H1', 'TCF12', 'TGFB1I1', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TGIF2', 'TOB1', 'TP53', 'TRIB3', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'TSC22D4', 'UCHL1', 'UCHL5', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWOX', 'WWP1', 'WWP2', 'YAP1', 'ZC3H12A', 'ZEB1', 'ZEB2', 'ZFYVE9', 'ZMIZ1'], 'Biochemical Activity': ['CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'CSNK1G2', 'MAPK1', 'NEDD4', 'NEDD4L', 'OTUB1', 'TGFBR1', 'USP15', 'USP7', 'WWP2'], 'Co-crystal Structure': ['SMAD3', 'SMAD4', 'ZFYVE9'], 'Co-fractionation': ['ALKBH2', 'ANAPC10', 'APP', 'ARID1B', 'CDH1', 'CREBBP', 'CTCF', 'CTNNB1', 'CUL1', 'DDR1', 'FOXO3', 'HDAC1', 'HMGA2', 'IGF1R', 'ITGB1', 'JUND', 'MTA2', 'NAA15', 'NT5DC3', 'PARP1', 'PRKDC', 'RBM14', 'RBX1', 'RELA', 'RIPK1', 'RNMT', 'SIN3A', 'SKP1', 'SMAD2', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SP1', 'SUB1', 'TRIM33', 'XRCC5', 'XRCC6', 'ZFHX3', 'ZFYVE9'], 'Co-localization': ['AKT1', 'BMP7', 'CAMK2G', 'CDK2', 'CDK4', 'EPAS1', 'ETS1', 'FOXO3', 'HIF1A', 'IRF7', 'MAP3K7', 'MAPK8', 'MAX', 'TP53', 'TRIM62'], 'Cross-Linking-MS (XL-MS)': ['RPL10A'], 'FRET': ['SMAD4', 'STUB1'], 'PCA': ['SMAD4', 'SMAD7'], 'Phenotypic Enhancement': ['HIF1A', 'SMAD2', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['JAK1'], 'Protein-RNA': ['LINC00941'], 'Protein-peptide': ['CREBBP', 'FOXH1', 'ITCH', 'LEF1', 'NEDD4', 'PIN1'], 'Proximity Label-MS': ['NFIA'], 'Reconstituted Complex': ['ANAPC10', 'APP', 'AR', 'ATF2', 'ATF3', 'BPTF', 'BRCA1', 'BRCA2', 'CEBPA', 'CEBPB', 'CEBPD', 'CITED2', 'CREBBP', 'CTCF', 'DAB2', 'DDX5', 'DEDD', 'DNMT3L', 'DVL1', 'E2F4', 'EID2', 'EIF4B', 'EP300', 'ERBB2IP', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXM1', 'GSK3B', 'HDAC1', 'HDAC4', 'HDAC5', 'HIF1A', 'HIPK2', 'HNF4A', 'HYAL2', 'IRF7', 'ITCH', 'JUN', 'JUNB', 'JUND', 'KAT2B', 'KAT6A', 'KPNB1', 'LCK', 'LEF1', 'LEMD3', 'MAX', 'MDM4', 'MECOM', 'MYC', 'MYOCD', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIA', 'NOTCH1', 'NR3C1', 'NUP153', 'NUP214', 'PARD3', 'PIAS2', 'PIAS3', 'PIAS4', 'PIK3CA', 'PIN1', 'RBL1', 'RUNX2', 'S100A4', 'SH2D2A', 'SIN3A', 'SKI', 'SKIL', 'SMAD3', 'SMAD4', 'SMURF2', 'SNW1', 'SP1', 'STUB1', 'TFE3', 'TGFB1I1', 'TGFBR1', 'TGIF1', 'TP53', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'UCHL5', 'USP15', 'VDR', 'WWOX', 'XPO6', 'YY1', 'ZFYVE9', 'ZMIZ1'], 'Two-hybrid': ['AATF', 'AES', 'ANK3', 'APMAP', 'APOB', 'AR', 'ATF2', 'BLZF1', 'C10ORF54', 'C14ORF105', 'CCDC33', 'CDC25A', 'CFDP1', 'CFH', 'CFLAR', 'CHRD', 'CORO1A', 'CPSF7', 'CPTP', 'CREBBP', 'CRX', 'CSH2', 'CXXC5', 'CYP11A1', 'DEDD', 'DNAJB4', 'DNAJB5', 'EBI3', 'EP300', 'EPAS1', 'FAM90A1', 'FBLN1', 'FLI1', 'FLNA', 'FOS', 'FOXH1', 'GGA1', 'GIT2', 'GMEB1', 'HDAC1', 'HEY1', 'HEYL', 'HIF1A', 'HIVEP1', 'HNRNPK', 'HOXC11', 'HP', 'ISL1', 'JUN', 'JUNB', 'KANSL1', 'KDM2A', 'KMT2B', 'LBP', 'MCM3AP', 'MEOX2', 'MTF2', 'MYC', 'MYD88', 'NCOA6', 'NEDD4', 'NEDD9', 'NR4A1', 'PAPPA', 'PARP4', 'PCDH1', 'PCK2', 'PHC2', 'PIAS4', 'PIN1', 'PLAG1', 'PLAGL1', 'PLG', 'PPP1R12C', 'PPP2R1A', 'PRDM4', 'PROX1', 'PSMB1', 'PSMD11', 'RANBP9', 'RBPMS', 'RBX1', 'RCVRN', 'RELA', 'RIOK2', 'RNF31', 'RPA1', 'RPLP0', 'SAP130', 'SBK3', 'SERTAD1', 'SETD2', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMURF1', 'SMURF2', 'SNRNP70', 'SNW1', 'SP1', 'SQSTM1', 'SS18L1', 'ST6GALNAC2', 'SVEP1', 'TANK', 'TDP2', 'TEKT4', 'TF', 'TGM2', 'TLR4', 'TMED1', 'TSC22D4', 'UBQLN4', 'USP7', 'VDR', 'WWP1', 'WWP2', 'XRCC6', 'ZBTB16', 'ZBTB3', 'ZC3H12A', 'ZCCHC14', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF329', 'ZNF774', 'ZNF83']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF6', 'ARHGEF7', 'CLASRP', 'FBXO3', 'GSC', 'MAP2K3', 'PPP2R2D', 'RAB38', 'RASD2', 'RGS3', 'RRAS2', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'WEE1', 'WWP2'], 'Affinity Capture-MS': ['ATG16L1', 'E6', 'NSP6', 'OTUB1', 'SMAD3'], 'Affinity Capture-Western': ['AXIN1', 'COL1A1', 'COL3A1', 'COL5A1', 'DDX5', 'DOK1', 'E6', 'E7', 'EP300', 'GATA4', 'GNB2L1', 'HCVGP1', 'HDAC4', 'KLF4', 'MED15', 'MELK', 'N', 'RNF111', 'SKI', 'SMAD3', 'SMAD3A', 'SMAD4', 'TGFB1I1', 'TOB1', 'TOB1A', 'TOB1B', 'VDR', 'ZEB1'], 'Co-localization': ['E7', 'N'], 'PCA': ['E6'], 'Phenotypic Enhancement': ['SMAD3A'], 'Phenotypic Suppression': ['SMAD3A'], 'Proximity Label-MS': ['M'], 'Reconstituted Complex': ['E6', 'E7', 'GATA4', 'N', 'SIN3A', 'SMAD3', 'SOX9', 'YAP1', 'ZFP128'], 'Synthetic Growth Defect': ['MMP9'], 'Two-hybrid': ['DVL1', 'E6', 'ERBB2IP', 'FOXH1', 'GATA4', 'HCVGP1', 'JUN', 'MAGI2', 'PARD3', 'SMAD3', 'ZEB2']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Large for gestational age', 'Alopecia', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Right ventricular hypertrophy', 'Myocardial fibrosis', 'Hallux valgus', 'Increased total eosinophil count', 'Acute kidney injury', 'Renal artery stenosis', 'Hypoglycemia', 'Glucose intolerance', 'Abnormal thrombosis', 'Rectal prolapse', 'Esophageal stricture', 'Pulmonary hypoplasia', 'Asthma', 'Cerebral cortical atrophy', 'Ischemic stroke', 'Aortic root aneurysm', 'Aortic dissection', 'Spontaneous pneumothorax', 'Vascular dilatation', 'Cerebral ischemia', 'Immunodeficiency', 'Systemic lupus erythematosus', 'Oral leukoplakia', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Back pain', 'Muscular dystrophy', 'Hernia of the abdominal wall', 'Cachexia', 'Ascending aortic dissection', 'Venous thrombosis', 'Ascending tubular aorta aneurysm', 'Ureteral obstruction', 'Airway obstruction', 'Pituitary prolactin cell adenoma', 'Premature ovarian insufficiency', 'Intervertebral disk degeneration', 'Lipodystrophy', 'Hamartoma', 'Chordoma', 'Stress urinary incontinence', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Urethral stricture', 'Allergy', 'Renal atrophy', 'Pulmonary bulla', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Hernia', 'Sepsis', 'Skin ulcer', 'Left ventricular dilatation', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'adolescent idiopathic scoliosis', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'gamma chain deficiency', 'seborrheic keratosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'smoking initiation', 'Staphylococcus aureus infection', 'rheumatic disease', 'lupus nephritis', 'pulse pressure measurement', 'neurodegenerative disease', 'retinal detachment', 'Autoimmune Hepatitis', 'non-high density lipoprotein cholesterol measurement', 'brain disease', 'aortic disease', 'neonatal abstinence syndrome', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'non-Hodgkins lymphoma', 'breast ductal adenocarcinoma', 'systolic blood pressure', 'diastolic blood pressure', 'pulmonary artery enlargement', 'laryngeal squamous cell carcinoma', 'cystadenocarcinoma', 'ovarian mucinous adenocarcinoma', 'smoking status measurement', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'cerebral amyloid angiopathy', 'autoimmune thyroid disease', 'stricture', 'head and neck malignant neoplasia', 'urgency urinary incontinence', 'fibrosis', 'diastolic blood pressure change measurement', 'drug use measurement', 'allergic conjunctivitis', 'aortic valve insufficiency', 'Balkan nephropathy', 'bronchiolitis obliterans', 'congenital rubella', 'coronavirus infectious disease', 'echinococcosis', 'endodermal sinus tumor', 'Gerstmann syndrome', 'Guillain-Barre syndrome', 'influenza', 'intestinal cancer', 'legionellosis', 'lymphatic system disease', 'male reproductive organ cancer', 'aneurysm-osteoarthritis syndrome', 'autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome', 'hyperuricemic nephropathy, familial juvenile type 3', 'graft versus host disease', 'autoimmune lymphoproliferative syndrome type 4', 'combined immunodeficiency due to LRBA deficiency', 'adenine phosphoribosyltransferase deficiency', 'karyomegalic interstitial nephritis', 'dyskeratosis congenita, autosomal recessive 5', 'TCR-alpha-beta-positive T-cell deficiency', 'severe combined immunodeficiency due to IKK2 deficiency', 'immunodeficiency 18', 'immunodeficiency 23', 'severe combined immunodeficiency due to CTPS1 deficiency', 'severe neurodegenerative syndrome with lipodystrophy', 'periodic fever-infantile enterocolitis-autoinflammatory syndrome', 'immunodeficiency 37', 'chronic atrial and intestinal dysrhythmia', 'DOCK2 deficiency', 'DDX41-related hematologic malignancy predisposition syndrome', 'fibrochondrogenesis 2', 'C3 glomerulonephritis', 'agammaglobulinemia 7, autosomal recessive', 'autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency', 'infantile-onset periodic fever-panniculitis-dermatosis syndrome', 'lung disease, immunodeficiency, and chromosome breakage syndrome;', 'neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade', 'chronic diarrhea due to glucoamylase deficiency', 'Bardet-Biedl syndrome', 'familial pancreatic carcinoma', 'nasopharyngeal carcinoma', 'craniosynostosis', 'keratoconus', 'common variable immunodeficiency', 'hyperplastic polyposis syndrome', 'dentin dysplasia', 'T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'qualitative or quantitative defects of dysferlin', 'holoprosencephaly', 'attenuated familial adenomatous polyposis', 'isolated agammaglobulinemia', 'pachyonychia congenita', 'familial hyperaldosteronism', 'hypohidrotic ectodermal dysplasia', 'primary ciliary dyskinesia', 'APC-related attenuated familial adenomatous polyposis', 'meningioma', 'multiple epiphyseal dysplasia', 'hemangioblastoma', 'Moyamoya disease', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'IgG4-related disease', 'juvenile polyposis syndrome', 'pituitary tumor', 'ameloblastoma', 'exstrophy-epispadias complex', 'autoimmune lymphoproliferative syndrome', 'syringomyelia', 'selective IgM deficiency', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', 'congestive heart failure', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'embryonal rhabdomyosarcoma', 'emphysema', 'epilepsy', 'fetal growth restriction', 'ganglioneuroma', 'gastric adenocarcinoma', 'esophageal adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'glioblastoma multiforme', 'hypertension', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'tuberculosis', 'glioblastoma', 'chronic granulomatous disease', 'liver mesenchymal hamartoma', 'activated PI3K-delta syndrome', 'carcinoma of liver and intrahepatic biliary tract', 'cutaneous polyarteritis nodosa', 'hereditary nonpolyposis colon cancer', 'Polymerase proofreading-related adenomatous polyposis', 'Zika virus infectious disease', 'regressive spondylometaphyseal dysplasia', 'Jeune syndrome', 'Li-Fraumeni syndrome', 'posterior cortical atrophy', '22q11.2 deletion syndrome', 'Loeys-Dietz syndrome', 'congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization', 'intrahepatic cholestasis', 'bronchopulmonary dysplasia', 'Hirschsprung disease', 'mucinous adenocarcinoma of the appendix', 'Lhermitte-Duclos disease', 'sarcoidosis', 'peeling skin syndrome', 'Fanconi anemia', 'dysspondyloenchondromatosis', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'acute liver failure', 'discoid lupus erythematosus', 'familial thoracic aortic aneurysm and aortic dissection', 'renal hypoplasia', 'renal dysplasia', 'spondyloepiphyseal dysplasia tarda', 'ulnar hemimelia', 'radial hemimelia', 'growth hormone-producing pituitary gland neoplasm', 'encephalitis', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'autosomal dominant cerebellar ataxia', 'precursor B-cell acute lymphoblastic leukemia', 'chronic graft versus host disease', 'superficial spreading melanoma', 'renal pelvis/ureter urothelial carcinoma', 'tubulointerstitial kidney disease, autosomal dominant, 2', 'lung neoplasm', 'intestinal neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'neoplasm of esophagus', 'tumor of parathyroid gland', 'polyp of colon', 'low grade glioma', 'coronary atherosclerosis', 'gram-negative bacterial infections', 'sexually transmitted disease', 'radiculitis', 'viral myocarditis', 'lip and oral cavity carcinoma', 'immunodeficiency 14b, autosomal recessive', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'respiratory tract infectious disorder', 'chondrogenic neoplasm', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'synucleinopathy', 'pulmonary sarcoidosis', 'gonorrhea', 'chronic lymphocytic leukemia', 'neoplasm of mature B-cells', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'metastatic prostate cancer', 'T-cell acute lymphoblastic leukemia', 'unspecified peripheral T-cell lymphoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'oral squamous cell carcinoma', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'adenocarcinoma', 'adenoma', 'adenosquamous lung carcinoma', 'adrenal gland pheochromocytoma', 'alveolar rhabdomyosarcoma', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', 'benign prostatic hyperplasia', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'Burkitts lymphoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'chondrosarcoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'chronic pancreatitis', 'clear cell renal carcinoma', 'endometrial carcinoma', 'renal fibrosis', 'Adenomyosis', 'immunoproliferative small intestinal disease', 'Posterior Leukoencephalopathy Syndrome', 'amyloidosis', 'neuroendocrine neoplasm', 'Spinal cord injury', 'B-cell non-Hodgkins lymphoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'intrahepatic cholangiocarcinoma', 'pharyngeal squamous cell carcinoma', 'connective tissue disease', 'pneumonitis', 'Carcinoma, Lewis Lung', 'soft tissue sarcoma', 'adult onset asthma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'renal hypertension', 'glomerular disease', 'nephritis', 'positive regulation of ovulation', 'Neurogenic bladder', 'Inguinal hernia', 'Abnormality of the urinary system', 'Renal insufficiency', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Nephrocalcinosis', 'Uterine leiomyoma', 'Cleft palate', 'Retrognathia', 'Strabismus', 'Cataract', 'Proptosis', 'Myopia', 'Pectus excavatum', 'Infertility', 'Hematuria', 'Diabetes mellitus', 'Hyperinsulinemia', 'Insulin resistance', 'Abnormality of the skeletal system', 'Osteopenia', 'Osteoporosis', 'Jaundice', 'Eczematoid dermatitis', 'Global developmental delay', 'Stroke', 'Encephalopathy', 'Parkinsonism', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Cholestasis', 'Hepatic steatosis', 'Obesity', 'ornithine carbamoyltransferase deficiency', 'pseudomyxoma peritonei', 'silicosis', 'spinal stenosis', 'BMI-adjusted waist-hip ratio', 'BMI-adjusted waist circumference', 'body fat percentage', 'balding measurement', 'liver dysplastic nodule', 'wellbeing measurement', 'insomnia measurement', 'eosinophil percentage of leukocytes', 'eosinophil percentage of granulocytes', 'BMI-adjusted hip circumference', 'calf circumference measurement', 'chronic hepatitis', 'dysplasia', 'interstitial cystitis', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'oral lichen planus', 'rhinitis', 'small cell carcinoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'Hepatobiliary Neoplasm', 'acute myocardial infarction', 'peritonitis', 'pemphigus foliaceus', 'paraneoplastic pemphigus', 'cystic kidney disease', 'ovarian dysfunction', 'Arteritis', 'Polyarteritis Nodosa', 'arteriosclerosis', 'idiopathic dilated cardiomyopathy', 'hyperuricemia', 'female reproductive endometrioid cancer', 'skin carcinoma', 'heel bone mineral density', 'marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections', 'central nervous system disease', 'sum of eosinophil and basophil counts', 'lower respiratory tract disease', 'pulmonary fibrosis', 'infarction', 'corneal disease', 'vertebral joint disease', 'aortic valve disease', 'cervical disc degenerative disorder', 'hemorrhoid', 'mitral valve disease', 'feeling nervous measurement', 'stomach disease', 'myocarditis', 'aneurysm', 'laryngeal disease', 'musculoskeletal system disease', 'Gallbladder Adenocarcinoma', 'Gallbladder Adenoma', 'Gastric Neuroendocrine Tumor G1', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Mast Cell Sarcoma', 'Nasal Cavity Polyp', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Ovarian Granulosa Cell Tumor', 'Peritoneal Multicystic Mesothelioma', 'Pituitary Gland Adenoma', 'Placental Choriocarcinoma', 'Pleural Epithelioid Mesothelioma', 'Poorly Differentiated Thyroid Gland Carcinoma', 'Rectal Tubular Adenoma', 'Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions', 'Signet Ring Cell Gastric Adenocarcinoma', 'small intestinal adenocarcinoma', 'Spinal Chordoma', 'Testicular Embryonal Carcinoma', 'Thyroid Gland Oncocytic Follicular Carcinoma', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vaginal Melanoma', 'hamartoma', 'acute respiratory distress syndrome', 'rectum cancer', 'acanthosis nigricans', 'cholesteatoma', 'Primary Pulmonary Diffuse Large B-Cell Lymphoma', 'developmental dysplasia of the hip', 'sarcopenia', 'mucous membrane pemphigoid', 'osteoarthritis, hip', 'osteoarthritis, spine', 'adrenal cortex carcinoma', 'adrenal gland hyperfunction', 'alcoholic cardiomyopathy', 'aortitis', 'atrial heart septal defect', 'causalgia', 'coronary aneurysm', 'diastolic heart failure', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'joint disease', 'lipoid nephrosis', 'mouth disease', 'multiple system atrophy', 'myeloid sarcoma', 'ocular hypertension', 'parathyroid adenoma', 'proliferative vitreoretinopathy', 'pulmonary edema', 'pulpitis', 'Raynaud disease', 'renovascular hypertension', 'rheumatic heart disease', 'Schnitzler syndrome', 'thromboangiitis obliterans', 'ulcerative proctosigmoiditis', 'uremia', 'non-alcoholic steatohepatitis', 'rotator cuff tear', 'Anemia, Hemolytic, Autoimmune', 'Cardiac Tamponade', 'End Stage Liver Disease', 'Endometritis', 'Escherichia coli Infections', 'Genital neoplasm, female', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Lentivirus Infections', 'Myocardial Ischemia', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Tularemia', 'diabetic cardiomyopathy', 'endothelial dysfunction', 'gliosarcoma', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'metastatic colorectal cancer', 'enterocolitis', 'primary biliary cirrhosis', 'abortion', 'psoriasis vulgaris', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'primary hyperoxaluria type 2', 'hyperimmunoglobulinemia D with periodic fever', 'autosomal recessive polycystic kidney disease', 'Senior-Loken syndrome 1', 'reticular dysgenesis', 'schneckenbecken dysplasia', 'combined immunodeficiency due to ZAP70 deficiency', 'familial isolated congenital asplenia', 'brachyolmia type 1, Hobaek type', 'brachyolmia type 1, toledo type', 'spondyloperipheral dysplasia', 'thoracomelic dysplasia', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'Wilson disease', 'X-linked spondyloepimetaphyseal dysplasia', 'hypoxanthine guanine phosphoribosyltransferase partial deficiency', 'Bruton-type agammaglobulinemia', 'X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia', 'combined immunodeficiency due to moesin deficiency', 'Wiskott-Aldrich syndrome', 'Aarskog-Scott syndrome, X-linked', 'hyper-IgM syndrome type 1', 'Melnick-Needles syndrome', 'Bartsocas-Papas syndrome 1', 'pulmonary venoocclusive disease', 'spondyloepimetaphyseal dysplasia, Irapa type', 'SHOX-related short stature', 'immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'spondyloepiphyseal dysplasia tarda, X-linked', 'T-B+ severe combined immunodeficiency due to JAK3 deficiency', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'skeletal dysplasia-epilepsy-short stature syndrome', 'hereditary mixed polyposis syndrome', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive', 'Ehlers-Danlos syndrome, musculocontractural type', 'spondyloepimetaphyseal dysplasia, Missouri type', 'axial spondylometaphyseal dysplasia', 'severe combined immunodeficiency due to DCLRE1C deficiency', 'spondyloepimetaphyseal dysplasia, Shohat type', 'myotonic dystrophy type 2', 'radioulnar synostosis-microcephaly-scoliosis syndrome', 'spondyloepimetaphyseal dysplasia with multiple dislocations', 'Omenn syndrome', 'xanthinuria type II', 'autoimmune lymphoproliferative syndrome type 2A', 'nephronophthisis 3', 'pyogenic arthritis-pyoderma gangrenosum-acne syndrome', 'hyper-IgM syndrome type 2', 'immunodeficiency due to CD25 deficiency', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'hyper-IgM syndrome type 3', 'multiple epiphyseal dysplasia type 5', 'anauxetic dysplasia', 'autoimmune lymphoproliferative syndrome type 2B', 'Smith-McCort dysplasia 1', 'granular corneal dystrophy type II', 'acrocapitofemoral dysplasia', 'endometrial cancer', 'hyper-IgM syndrome type 5', 'hyper-IgM syndrome type 4', 'neutrophil immunodeficiency syndrome', 'familial adenomatous polyposis 2', 'spondyloepimetaphyseal dysplasia, matrilin-3 type', 'familial avascular necrosis of femoral head', 'immunodeficiency 104', 'spondylometaphyseal dysplasia, A4 type', 'epidermolysis bullosa simplex 7, with nephropathy and deafness', 'permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome', 'mesoaxial synostotic syndactyly with phalangeal reduction', 'hyperinsulinemic hypoglycemia, familial, 4', 'Mungan syndrome', 'familial cold autoinflammatory syndrome 2', 'aortic aneurysm, familial thoracic 6', 'hypouricemia, renal, 2', 'dopa-responsive dystonia due to sepiapterin reductase deficiency', 'combined immunodeficiency due to STIM1 deficiency', 'atypical hemolytic-uremic syndrome with MCP/CD46 anomaly', 'atypical hemolytic-uremic syndrome with I factor anomaly', 'atypical hemolytic-uremic syndrome with B factor anomaly', 'atypical hemolytic-uremic syndrome with C3 anomaly', 'atypical hemolytic-uremic syndrome with thrombomodulin anomaly', 'lymphoproliferative syndrome 1', 'purine nucleoside phosphorylase deficiency', 'spondylo-megaepiphyseal-metaphyseal dysplasia', 'brachydactylous dwarfism, Mseleni type', 'spondyloepimetaphyseal dysplasia, Handigodu type', 'hemolytic anemia due to glucophosphate isomerase deficiency', 'alpha 1-antitrypsin deficiency', 'occult macular dystrophy', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'polyp', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'renal cell carcinoma', 'respiratory system disease', 'sarcoma', 'severe acute respiratory syndrome', 'Sjogren syndrome', 'skin disease', 'small cell lung carcinoma', 'rheumatoid arthritis', 'spindle cell tumor', 'spondyloarthropathy', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'systemic scleroderma', 'ulcerative colitis', 'uterine fibroid', 'melanoma', 'malignant peripheral nerve sheath tumor', 'viral disease', 'HIV infection', 'AIDS', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'temporal lobe epilepsy', 'myositis', 'leprosy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'Down syndrome', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'lung carcinoma', 'ovarian carcinoma', 'post-traumatic stress disorder', 'pulmonary arterial hypertension', 'synovial sarcoma', 'autosomal dominant polycystic liver disease', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'small intestinal neuroendocrine tumor G1', 'breast benign neoplasm', 'central nervous system primitive neuroectodermal neoplasm', 'vertebral column disorder', 'cerebral cavernous malformation', 'interstitial emphysema', 'gastric cancer', 'essential hypertension', 'hypertensive heart disease', 'familial hyperlipidemia', 'impaired renal function disease', 'myopia', 'nephrocalcinosis', 'leiomyoma', 'prolapse of female genital organ', 'brain cancer', 'nontoxic goiter', 'pure red-cell aplasia', 'crescentic glomerulonephritis', 'tuberous sclerosis', 'depressive disorder', 'ventricular septal defect', 'pneumothorax', 'Richter syndrome', 'thyroid cancer', 'giant cell tumor', 'spondylosis', 'papilloma', 'kidney cancer', 'dermatitis', 'prostatic adenoma', 'lobular neoplasia', 'gingival overgrowth', 'papillary adenocarcinoma', 'digestive system cancer', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratocarcinoma', 'teratoma', 'bone inflammation disease', 'small cell osteogenic sarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'anal canal adenocarcinoma', 'skin cancer', 'cerebellar neoplasm', 'cervical cancer', 'breast angiosarcoma', 'bile duct adenocarcinoma', 'thoracic cancer', 'colonic disorder', 'functioning pituitary gland adenoma', 'anal canal squamous cell carcinoma', 'pancreatic intraductal papillary-mucinous neoplasm', 'muscular atrophy', 'female breast carcinoma', 'retinal degeneration', 'MHC class II deficiency 4', 'immunodeficiency 122', 'inflammation', 'circulating fibrinogen levels', 'glomerular filtration rate', 'fat pad mass', 'hip circumference', 'bone tissue density', 'von Willebrand factor quality', 'waist circumference', 'age of onset of asthma', 'level of serum globulin type protein', 'red blood cell density', 'serum alanine aminotransferase amount', 'heart rate', 'age of onset of allergic disease', 'brain volume', 'serum albumin amount', 'serum creatinine amount', 'body height', 'cyst', 'X-linked hyper-IgM syndrome', 'Brachydactyly - elbow wrist dysplasia', 'Chronic mucocutaneous candidosis', 'Desbuquois syndrome', 'Chédiak-Higashi syndrome', 'Recurrent infection due to specific granule deficiency', 'Immunodeficiency syndrome with autoimmunity', 'Metaphyseal chondrodysplasia, Schmid type', 'Åland Islands eye disease', 'Ichthyosis - intellectual disability - dwarfism - renal impairment', 'Autosomal recessive early-onset inflammatory bowel disease', 'X-linked lymphoproliferative disease', 'Metaphyseal dysostosis - intellectual disability - conductive deafness', 'CHST3-related skeletal dysplasia', 'Cyclic neutropenia', 'Severe combined immunodeficiency due to adenosine deaminase deficiency', 'Aneurysm - osteoarthritis syndrome', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Multiple osteochondromas', 'Recurrent infections-myelofibrosis-nephromegaly syndrome', 'Acromesomelic dysplasia, Maroteaux type', 'Hyperlipoproteinemia type 1', 'X-linked agammaglobulinemia', 'Familial hemophagocytic lymphohistiocytosis', 'Immunodeficiency by defective expression of HLA class 2', 'Pyogenic arthritis - pyoderma gangrenosum - acne', 'Familial adenomatous polyposis', 'Thymic aplasia', 'Other metabolic disease', 'Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification', 'Hypohidrotic ectodermal dysplasia with immunodeficiency', 'Leukocyte adhesion deficiency type III', 'hematocrit', 'C-reactive protein measurement', 'glucose measurement', 'hemoglobin measurement', 'bone quantitative ultrasound measurement', 'triglyceride measurement', 'alkaline phosphatase measurement', 'creatine kinase measurement', 'cryptorchidism', 'total cholesterol measurement', 'gestational diabetes', 'low density lipoprotein cholesterol measurement', 'lymphocyte count', 'acute lung injury', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'cystatin C measurement', 'factor VII measurement', 'IGF-1 measurement', 'factor VIII measurement', 'white matter integrity', 'hip geometry', 'factor XI measurement', 'intraocular pressure measurement', 'sex hormone-binding globulin measurement', 'age at menarche', 'pelvic organ prolapse', 'FEV/FVC ratio', 'prion disease', 'aspartate aminotransferase measurement', 'protein measurement', 'neutrophil count', 'eosinophil count', 'lymph node metastatic carcinoma', 'appendicular lean mass', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'autoimmune disease', 'congenital heart disease', 'central corneal thickness', 'cholangiocarcinoma', 'reading', 'anxiety', 'primitive neuroectodermal tumor', 'aortic valve calcification', 'non-small cell lung adenocarcinoma', 'axial length measurement', 'contact dermatitis', 'vein disorder', 'in situ carcinoma', 'inborn disorder of amino acid metabolism', 'allergic asthma', 'fatty liver disease', 'alopecia', 'hypoplastic left heart syndrome', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'upper respiratory tract disorder', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'Parkinson disease', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'allergic disease', 'multiple sclerosis', 'skin basal cell carcinoma', 'childhood onset asthma', 'colorectal cancer', 'Lynch syndrome', 'Wilms tumor', 'prune belly syndrome', 'Adams-Oliver syndrome', 'Acropectorovertebral dysplasia', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency', 'Tietz syndrome', 'autosomal dominant Alport syndrome', 'Townes-Brocks syndrome', 'atelosteogenesis type III', 'Osebold-Remondini syndrome', 'brachydactyly type C', 'autosomal dominant brachyolmia', 'Gordon syndrome', 'breast cancer', 'chondrocalcinosis 2', 'congenital contractural arachnodactyly', 'fleck corneal dystrophy', 'Duane retraction syndrome', 'Leri-Weill dyschondrosteosis', 'Beckwith-Wiedemann syndrome', 'esophageal cancer', 'autoinflammatory syndrome, familial, X-linked, Behcet-like 2', 'immunodeficiency 98 with autoinflammation, X-linked', 'metastatic malignant neoplasm', 'granulomatous disease, chronic, autosomal recessive, 5', 'hyper-IgE recurrent infection syndrome 5, autosomal recessive', 'immunodeficiency 81', 'immunodeficiency 82 with systemic inflammation', 'inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive', 'immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias', 'immunodeficiency 75', 'immunodeficiency 76', 'nephrotic syndrome 16', 'immunodeficiency 69', 'immunodeficiency 78 with autoimmunity and developmental delay', 'immunodeficiency 70', 'immunodeficiency 72 with autoinflammation', 'immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia', 'autoinflammation, immune dysregulation, and eosinophilia', 'severe combined immunodeficiency due to CD70 deficiency', 'myofibroblastoma', 'invasive carcinoma', 'adenoviridae infectious disease', 'brain injury', 'nosocomial infection', 'enteritis', 'ulcer disease', 'radiation pneumonitis', 'familial adenomatous polyposis 4', 'severe combined immunodeficiency due to LAT deficiency', 'desmoplastic melanoma', 'myelofibrosis', 'salivary duct carcinoma', 'oral cavity carcinoma', 'rectal carcinoma', 'vertebral disorder', 'digestive system melanoma', 'short-rib thoracic dysplasia 17 with or without polydactyly', 'platelet abnormalities with eosinophilia and immune-mediated inflammatory disease', 'COVID-19', 'liver failure', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'spondyloepimetaphyseal dysplasia', 'gastrointestinal defects and immunodeficiency syndrome 1', 'immunodeficiency 105', 'autoinflammatory disease, X-linked', 'autoinflammatory syndrome with immunodeficiency', 'achalasia-alacrima syndrome', 'choroidal neovascularization', 'rhizomelic dysplasia, Ain-Naz type', 'autoinflammatory disease, multisystem, with immune dysregulation, X-linked', 'hyper-IgE syndrome 6, autosomal dominant, with recurrent infections', 'immunodeficiency 113 with autoimmunity and autoinflammation', 'immunodeficiency 117', 'neutropenia, severe congenital, 11, autosomal dominant', 'autoinflammation with episodic fever and immune dysregulation', 'immunodeficiency 119', 'postmenopausal osteoporosis', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'ankylosing spondylitis', 'deep vein thrombosis', 'angina pectoris', 'atherosclerosis', 'necrotizing enterocolitis', 'gastroesophageal reflux disease', 'seasonal allergic rhinitis', 'breast neoplasm', 'left ventricular hypertrophy', 'stomach neoplasm', 'obstructive sleep apnea', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'neuropathy', 'open-angle glaucoma', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Vitiligo', 'hypospadias', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'exfoliation syndrome', 'focal segmental glomerulosclerosis', 'chronic hepatitis B virus infection', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'meningococcal infection', 'membranous glomerulonephritis', 'nephrotic syndrome', 'osteonecrosis', 'bone disease', 'vascular disease', 'peripheral arterial disease', 'sclerosing cholangitis', 'scoliosis', 'brain infarction', 'thoracic aortic aneurysm', 'ventricular fibrillation', 'colonic neoplasm', 'erythrocyte count', 'platelet count', 'vital capacity', 'forced expiratory volume', 'smoking behavior', 'body weight', 'body mass index', 'body fat distribution', 'waist-hip ratio', 'corneal topography', 'neuroimaging measurement', 'metastatic neoplasm', 'wheezing', 'enthesitis-related juvenile idiopathic arthritis', 'Chronic Obstructive Asthma', 'carotid atherosclerosis', 'pulse wave reflection index measurement', 'total hip arthroplasty', 'kidney injury', 'muscle atrophy', 'chromosomal aberration frequency', 'bone metastasis', 'HMG CoA reductase inhibitor use measurement', 'Inhalant adrenergic use measurement', 'Glucocorticoid use measurement', 'low density lipoprotein triglyceride measurement', 'diverticular disease', 'corneal resistance factor', 'citrate measurement', 'cholesteryl ester measurement', 'glucuronate measurement', 'isocitrate measurement', 'atopic asthma', 'coinfection', 'total joint arthroplasty', 'aspartate aminotransferase to alanine aminotransferase ratio', 'nephrotoxicity', 'inflammatory bowel disease, immunodeficiency, and encephalopathy', 'severe malarial anemia', 'total knee arthroplasty', 'palmitate 16:0 measurement', 'sexual dimorphism measurement', 'body surface area', 'serum lipopolysaccharide activity', 'Birt-Hogg-Dube syndrome', '25-hydroxyvitamin D3 measurement', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'granulosa cell tumor', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'pulmonary tuberculosis', 'tongue squamous cell carcinoma', 'nasopharyngeal squamous cell carcinoma', 'Acute Leukemia', 'Ampulla of Vater Carcinoma', 'Appendix Adenocarcinoma', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Cavernous Hemangioma', 'Central Nervous System Lymphoma', 'Cervical Adenosquamous Carcinoma', 'cervical squamous cell carcinoma', 'Colon Dysplasia', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Endometrial Undifferentiated Carcinoma', 'Fibroblastic Neoplasm', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'nonpapillary renal cell carcinoma', 'Pallister-Hall syndrome', 'periodic fever, immunodeficiency, and thrombocytopenia syndrome', 'platyspondylic dysplasia, Torrance type', 'systemic lupus erythematosus', 'Marfan syndrome', 'melorheostosis', 'mesomelic dysplasia, Kantaputra type', 'metatropic dysplasia', 'Mobius syndrome', 'Muir-Torre syndrome', 'Cowden syndrome 1', 'myotonic dystrophy type 1', 'nail-patella syndrome', 'autosomal dominant progressive nephropathy with hypertension', 'ovarian cancer', 'Peyronie disease', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'Hutchinson-Gilford progeria syndrome', 'familial juvenile hyperuricemic nephropathy type 1', 'Peutz-Jeghers syndrome', 'prostate cancer', 'pseudoachondroplasia', 'autosomal dominant distal renal tubular acidosis', 'retinoblastoma', 'Smith-Magenis syndrome', 'spondyloepiphyseal dysplasia tarda, autosomal dominant', 'spondyloepimetaphyseal dysplasia, Strudwick type', 'spondylometaphyseal dysplasia, Kozlowski type', 'spondylometaphyseal dysplasia, Schmidt type', 'proximal symphalangism', 'syndactyly type 5', 'brachydactyly-elbow wrist dysplasia syndrome', 'tarsal-carpal coalition syndrome', 'thoracolaryngopelvic dysplasia', 'tooth and nail syndrome', 'volvulus of midgut', 'short-limb skeletal dysplasia with severe combined immunodeficiency', 'acrocallosal syndrome', 'acrodermatitis enteropathica', 'acromesomelic dysplasia 2C, Hunter-Thompson type', 'agnathia-otocephaly complex', 'autosomal recessive Alport syndrome', 'amelogenesis imperfecta type 1G', 'microphthalmia with limb anomalies', 'progressive pseudorheumatoid arthropathy of childhood', 'Bloom syndrome', 'kyphomelic dysplasia', 'lung cancer', 'heart defects-limb shortening syndrome', 'chordoma', 'Juberg-Hayward syndrome', 'Costello syndrome', 'cystic fibrosis', 'hereditary renal hypouricemia', 'diastrophic dysplasia', 'Dyggve-Melchior-Clausen disease', 'Ehlers-Danlos syndrome, dermatosparaxis type', 'multiple epiphyseal dysplasia type 4', 'classic Hodgkin lymphoma', 'immunodeficiency, common variable, 2', 'ichthyosis-intellectual disability-dwarfism-renal impairment syndrome', 'Nezelof syndrome', 'spondylometaphyseal dysplasia, Sedaghatian type', 'metaphyseal dysostosis-intellectual disability-conductive deafness syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'carnitine palmitoyl transferase II deficiency, myopathic form', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'nail-patella-like renal disease', 'nephronophthisis 1', 'congenital nephrotic syndrome, Finnish type', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'human papilloma virus infection', 'fibrosarcoma', 'benign neoplasm', 'hypertrophy', 'anaplastic astrocytoma', 'cardiac hypertrophy', 'medical procedure', 'AIDS dementia', 'juvenile idiopathic arthritis', 'insulin resistance', 'prostate intraepithelial neoplasia', 'septic peritonitis', 'vulvar intraepithelial neoplasia', 'renal carcinoma', 'thyroid carcinoma', 'metastatic melanoma', 'pancreatic carcinoma', 'rotavirus infection', 'Cutaneous T-cell lymphoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'muscular disease', 'transitional cell carcinoma of kidney', 'anaplastic large cell lymphoma', 'bacteriemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'peripheral neuropathy', 'testicular seminoma', 'pneumonia', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'refractory anemia with ringed sideroblasts', 'laryngeal neoplasm', 'lung disease', 'brain neoplasm', 'calcification', 'retinopathy', 'thyroid neoplasm'], tissue_specific_expression={'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\"small intestine Peyer's patch\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}, is_essential=False, genetic_constraint={'syn': -0.12650999426841736, 'mis': 4.360300064086914, 'lof': 0.9999799728393555}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID']), 'SMAD3'\\n[Open Targets] Predictions fetched\\n*NAME* reactome\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': ['SMAD2', 'SMAD3'], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id='Q15796', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma'], diseases=['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['SMAD3', 'SMAD4', 'SMURF2'], 'Affinity Capture-MS': ['ARID1A', 'ARID1B', 'ASH2L', 'ATAD3B', 'BCL7A', 'BTBD9', 'BUB3', 'C1ORF116', 'CAD', 'CCT6A', 'CDC27', 'CGA', 'CPSF7', 'CREBBP', 'CSNK1D', 'CTNNB1', 'CUL4A', 'CUL4B', 'DCAF7', 'DDX3Y', 'DGKA', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'EPB41L5', 'ERBB2IP', 'EZH2', 'FAM83G', 'FLOT1', 'FLOT2', 'FYN', 'GSK3A', 'GTF3C2', 'GTF3C6', 'HCFC1', 'HDAC2', 'HDAC4', 'HINT3', 'HSPA4', 'ITGB4', 'KLF5', 'KMT2C', 'LDLRAD4', 'LEMD3', 'MED15', 'MED16', 'MED17', 'MED19', 'MED20', 'MED22', 'MED25', 'MED31', 'MED4', 'MED9', 'MEN1', 'MTMR4', 'NCOA3', 'OGT', 'OPA1', 'OTUB1', 'PARK2', 'PCBP1', 'PCID2', 'PLEKHA4', 'PSPC1', 'RIN1', 'SGSH', 'SIK3', 'SKI', 'SKIL', 'SLC25A3', 'SLC25A5', 'SLC25A6', 'SMAD1', 'SMAD3', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMARCD2', 'SMPDL3B', 'SMURF2', 'SNW1', 'SNX27', 'SQRDL', 'TAF1', 'TAF2', 'TAF3', 'TAF5', 'TAF6', 'TMED8', 'TMOD1', 'TRIM28', 'TRIM33', 'TRIM67', 'U2AF2', 'WDR82', 'WRNIP1', 'WWP2', 'YAF2', 'YY1', 'ZFYVE9'], 'Affinity Capture-RNA': ['DDX58', 'ELAVL1'], 'Affinity Capture-Western': ['ACVR1B', 'ACVR2B', 'AKT1', 'ANAPC10', 'ATF3', 'BRCA2', 'CDC16', 'CDC27', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DAB2', 'DOCK9', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'ETV4', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'FOXP1', 'GLI1', 'GTF2I', 'GTF2IRD1', 'HDAC1', 'HGS', 'HYAL2', 'ING2', 'INSR', 'IRF3', 'IRF7', 'ITCH', 'JUN', 'KAT2A', 'KAT2B', 'KDM6B', 'KLF5', 'LEF1', 'MAPT', 'MED15', 'MED24', 'MED6', 'MEF2A', 'METTL14', 'METTL3', 'MYC', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFYC', 'NOTCH4', 'NUP214', 'OTUB1', 'OVOL2', 'PIAS3', 'PIAS4', 'PIN1', 'PML', 'PRDM16', 'RBBP5', 'RELB', 'RGCC', 'RNF111', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD6', 'SMAD7', 'SMARCA4', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'STRAP', 'TCF12', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TP53', 'TRIM28', 'TRIM33', 'TSC2', 'UCHL1', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWP1', 'WWP2', 'YAP1', 'ZEB1', 'ZFYVE9'], 'Biochemical Activity': ['ACVR1B', 'CAMK2G', 'CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'ITCH', 'TGFBR1'], 'Co-crystal Structure': ['SMAD4'], 'Co-fractionation': ['AP1M1', 'ARID1B', 'CAV1', 'CREBBP', 'CTNNB1', 'HDAC1', 'HMGA2', 'MTA2', 'NAA15', 'NCOA3', 'PARP1', 'PML', 'PRKDC', 'RBM14', 'RELA', 'SMAD3', 'SMAD4', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SUB1', 'TGFBR1', 'TRIM33', 'XRCC6', 'ZFYVE9'], 'Co-localization': ['CAMK2A', 'TGFBR1', 'TP53'], 'FRET': ['BECN1', 'LATS2', 'MYC', 'SMAD1'], 'Phenotypic Enhancement': ['SMAD3', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['SPPL3'], 'Proximity Label-MS': ['CCNF', 'EPHA2', 'OPTN', 'RAB7A', 'SNCA', 'TGOLN2'], 'Reconstituted Complex': ['ANAPC10', 'ANP32B', 'ANP32E', 'ATP5I', 'BPTF', 'CREBBP', 'DAB2', 'DVL1', 'ELAC2', 'ERBB2IP', 'ESR1', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'HDAC2', 'HIPK2', 'HYAL2', 'INSR', 'IRF7', 'JUN', 'KAT2B', 'LCK', 'LEF1', 'MECOM', 'MEF2A', 'MEF2C', 'MYC', 'MYOCD', 'NEDD4L', 'NEFM', 'NFIA', 'NUP214', 'OTUB1', 'PARD3', 'PIAS3', 'PIK3CA', 'PIN1', 'PTMS', 'RHOA', 'SH2D2A', 'SKI', 'SMAD4', 'SMAD7', 'SMURF2', 'SNW1', 'SOD1', 'SP1', 'STUB1', 'SYT1', 'TP53', 'TUBA1B', 'UCHL5', 'YY1', 'ZFYVE9'], 'Two-hybrid': ['ABTB1', 'AKT1', 'ANAPC2', 'ANK3', 'ANTXR2', 'BAZ1A', 'BTBD2', 'C22ORF46', 'C9ORF156', 'CISH', 'COPS5', 'CORO2A', 'CREBBP', 'CSH1', 'CSH2', 'CUL5', 'CYLC2', 'CYP11A1', 'DCUN1D1', 'DNAJB5', 'DNAJC7', 'DOCK8', 'DYNC1H1', 'DYRK1A', 'EEF1A1', 'EIF3L', 'EP300', 'ETV4', 'FAM161B', 'FBP2', 'FOXH1', 'GATAD2B', 'GFER', 'HSD17B3', 'INSR', 'KHDRBS1', 'KIAA1033', 'KPNB1', 'LAMA5', 'LEMD3', 'MAP2K1', 'MLLT4', 'MYC', 'NAGK', 'NCOA6', 'NEDD4L', 'OS9', 'PAPOLA', 'PAPPA', 'PAXIP1', 'PEX19', 'PIAS4', 'PLIN3', 'POU2AF1', 'PPP2R1A', 'PRKAR1A', 'PSAP', 'PSG9', 'PSMD11', 'PSMD8', 'RANBP6', 'RANBP9', 'RARB', 'RASA1', 'RNF123', 'RNPC3', 'ROCK1', 'RPS14', 'RPS27A', 'RXRA', 'SKI', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD9', 'SMURF1', 'SMURF2', 'SNAPIN', 'SNIP1', 'SNRNP70', 'SNW1', 'SP1', 'SRI', 'ST13', 'ST5', 'TBC1D1', 'TGIF1', 'TGM2', 'TRIM62', 'UBA52', 'UBR5', 'XPA', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF41', 'ZNF510', 'ZNHIT6']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF1', 'ARHGEF6', 'ARHGEF7', 'ARL4D', 'CDC40', 'FBXO3', 'IRAK2', 'LHX9', 'LMO2', 'MAP2K3', 'NUAK2', 'PPP2R2D', 'RAB34', 'RAB38', 'RASD2', 'RGS3', 'RHEBL1', 'RHOBTB1', 'RHOD', 'RHOJ', 'RPS27A', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'UHMK1', 'WWP2'], 'Affinity Capture-MS': ['ALDH4A1', 'BACH1', 'E6', 'FANCD2', 'NSP16AB', 'OTUB1', 'PAXIP1', 'RUNX1'], 'Affinity Capture-Western': ['COL1A1', 'COL3A1', 'COL5A1', 'DOK1', 'E6', 'E7', 'GATA4', 'HCVGP1', 'KAP-ALPHA3', 'KLF4', 'LEF1', 'MED', 'MED15', 'MEF2A', 'RNF111', 'SKI', 'SMAD2', 'SMAD4', 'SMOX', 'SNOO', 'UBX', 'VIS', 'WWTR1', 'YAP1'], 'Co-localization': ['E7', 'EZH2-A', 'KLF4'], 'PCA': ['E6', 'SMOX'], 'Phenotypic Enhancement': ['BABO', 'INR', 'SMOX', 'YKI'], 'Phenotypic Suppression': ['BABO', 'HPO', 'INR', 'MYO', 'PLUM', 'PTEN', 'SCGDELTA', 'SMOX'], 'Reconstituted Complex': ['E7', 'LEMD3', 'SMAD2', 'SOX9', 'UBX', 'ZFP128'], 'Two-hybrid': ['CG18095', 'D', 'E6', 'EG', 'FOXH1', 'HOXA13', 'HOXD13', 'HR78', 'SMAD2', 'SMOX', 'UBX', 'ZEB2', 'ZEN']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Overgrowth', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Myocardial fibrosis', 'Increased total eosinophil count', 'Thrombocytosis', 'Anemia', 'Acute kidney injury', 'Glucose intolerance', 'Pulmonary hypoplasia', 'Pneumonia', 'Asthma', 'Ischemic stroke', 'Cerebral ischemia', 'Vascular dilatation', 'Aortic dissection', 'Systemic lupus erythematosus', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Skeletal muscle atrophy', 'Muscular dystrophy', 'Cachexia', 'Thrombophlebitis', 'Miscarriage', 'Ureteral obstruction', 'Airway obstruction', 'Amyotrophic lateral sclerosis', 'Peripheral demyelination', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Reduced sperm motility', 'Urethral stricture', 'Renal atrophy', 'Cervical polyp', 'Shock', 'Granuloma', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Sepsis', 'geleophysic dysplasia', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'hydronephrosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'renal cell adenocarcinoma', 'Autoimmune Hepatitis', 'neurodegenerative disease', 'brain disease', 'aortic disease', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'head and neck neoplasia', 'breast ductal adenocarcinoma', 'laryngeal squamous cell carcinoma', 'ovarian adenocarcinoma', 'ovarian mucinous adenocarcinoma', 'ovarian teratoma', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'dysplastic oral keratinocyte', 'undifferentiated carcinoma', 'cerebral amyloid angiopathy', 'head and neck malignant neoplasia', 'breastfeeding duration', 'urgency urinary incontinence', 'fibrosis', 'Balkan nephropathy', 'congenital rubella', 'echinococcosis', 'Gerstmann syndrome', 'inclusion body myositis', 'muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10', 'severe neurodegenerative syndrome with lipodystrophy', 'Diamond-Blackfan anemia', 'cardiofaciocutaneous syndrome', 'adrenomyeloneuropathy', 'hereditary sensory and autonomic neuropathy', 'nasopharyngeal carcinoma', 'keratoconus', 'dentin dysplasia', 'T-cell non-Hodgkin lymphoma', 'dyskeratosis congenita', 'pneumoconiosis', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'cryopyrin-associated periodic syndrome', 'holoprosencephaly', 'pachyonychia congenita', 'familial rhabdoid tumor', 'familial hyperaldosteronism', 'primary ciliary dyskinesia', 'meningioma', 'pilocytic astrocytoma', 'hemangioblastoma', 'microcephaly-brain defect-spasticity-hypernatremia syndrome', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'heritable pulmonary arterial hypertension', 'juvenile polyposis syndrome', 'congenital herpes simplex virus infection', 'popliteal pterygium syndrome', 'ameloblastoma', 'hypersensitivity pneumonitis', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'emphysema', 'epilepsy', 'esophageal adenocarcinoma', 'fetal growth restriction', 'follicular thyroid adenoma', 'ganglioneuroma', 'follicular thyroid carcinoma', 'gastric adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'genetic disorder', 'germ cell tumor', 'glioblastoma multiforme', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'large cell neuroendocrine carcinoma', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'neural tube defect', 'tuberculosis', 'glioblastoma', 'carcinoma of liver and intrahepatic biliary tract', 'hereditary nonpolyposis colon cancer', 'Zika virus infectious disease', 'left ventricular noncompaction', 'multiminicore myopathy', 'Loeys-Dietz syndrome', 'neurofibromatosis type 1', 'Leber congenital amaurosis', 'osteogenesis imperfecta', 'progressive supranuclear palsy', 'intrahepatic cholestasis', 'lymphedema', 'posterior cortical atrophy', 'follicular lymphoma', 'kidney Wilms tumor', 'bronchopulmonary dysplasia', 'sarcoidosis', 'peeling skin syndrome', 'lissencephaly with cerebellar hypoplasia', 'aggressive NK-cell leukemia', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'familial thoracic aortic aneurysm and aortic dissection', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'precursor B-cell acute lymphoblastic leukemia', 'superficial spreading melanoma', 'lung neoplasm', 'intestinal neoplasm', 'odontogenic neoplasm', 'disorder of ear', 'endometrium neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'carcinoma of pharynx', 'polyp of colon', 'low grade glioma', 'corticobasal degeneration disorder', 'cervical intraepithelial neoplasia', 'viral myocarditis', 'lip and oral cavity carcinoma', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'chondrogenic neoplasm', 'intraepithelial neoplasia', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'pulmonary sarcoidosis', 'gonorrhea', 'B-cell acute lymphoblastic leukemia', 'chronic lymphocytic leukemia', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'myelodysplastic syndrome', 'oral squamous cell carcinoma', 'gastritis', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'acute promyelocytic leukemia', 'adenocarcinoma', 'adenoma', 'age', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', \\\"Barrett's esophagus\\\", 'benign prostatic hyperplasia', 'bladder tumor', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'central nervous system cancer', 'chondrosarcoma', 'chromophobe renal cell carcinoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'clear cell renal carcinoma', 'endometrial carcinoma', 'ovarian serous carcinoma', 'renal fibrosis', 'Abruptio Placentae', 'Adenomyosis', 'Carcinoma, Lewis Lung', 'chronic myelomonocytic leukemia', 'Marchiafava-Bignami Disease', 'oral submucous fibrosis', 'osteoradionecrosis', 'renal nutcracker syndrome', 'amyloidosis', 'mucositis', 'neuroendocrine neoplasm', 'neuromuscular disease', 'oral mucositis', 'Spinal cord injury', 'cutaneous squamous cell carcinoma', 'Barrett adenocarcinoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'pharyngeal squamous cell carcinoma', 'soft tissue sarcoma', 'undifferentiated pleomorphic sarcoma', 'connective tissue disease', 'pneumonitis', 'intrahepatic cholangiocarcinoma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'glomerular disease', 'nephritis', 'Neurogenic bladder', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Uterine leiomyoma', 'Cleft palate', 'Hydrocephalus', 'Cataract', 'Myopia', 'Autism', 'Infertility', 'Diabetes mellitus', 'Insulin resistance', 'Osteoporosis', 'Hyperkeratosis', 'Intellectual disability', 'Ataxia', 'Mental deterioration', 'Stroke', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Hepatic steatosis', 'Obesity', 'mixed connective tissue disease', 'pneumocystosis', 'pseudomyxoma peritonei', 'silicosis', 'toxoplasmosis', 'hemoglobin A1 measurement', 'BMI-adjusted waist-hip ratio', 'liver dysplastic nodule', 'gut microbiome measurement', 'platelet crit', 'allergen exposure measurement', 'calf circumference measurement', 'dysplasia', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'digestive system neoplasm', 'Hepatobiliary Neoplasm', 'American trypanosomiasis', 'acute myocardial infarction', 'pemphigus foliaceus', 'cystic kidney disease', 'Polycystic Kidney Disease', 'arteriosclerosis', 'hyperuricemia', 'skin carcinoma', 'heel bone mineral density', 'pulmonary fibrosis', 'hyperaldosteronism', 'gastric ulcer', 'infarction', 'aortic valve disease', 'heart valve disease', 'mitral valve disease', 'urinary tract obstruction', 'prostate disease', 'stomach disease', 'myocarditis', 'aneurysm', 'enthesopathy', 'musculoskeletal system disease', 'metastasis', 'Gallbladder Adenocarcinoma', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Malignant Mesothelioma', 'Malignant Pancreatic Neoplasm', 'Medullomyoblastoma with Myogenic Differentiation', 'Microcystic Meningioma', 'Mixed Tumor of the Salivary Gland', 'Nasal Cavity Polyp', 'Osteoblastoma', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Paraganglioma', 'Placental Choriocarcinoma', 'Rectal Tubular Adenoma', 'Sarcomatoid Carcinoma', 'Signet Ring Cell Gastric Adenocarcinoma', 'Synovial Chondromatosis', 'Testicular Non-Seminomatous Germ Cell Tumor', 'Testicular Yolk Sac Tumor', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vulvar Squamous Cell Carcinoma', 'acute respiratory distress syndrome', 'sarcopenia', 'rectum cancer', 'acanthosis nigricans', 'mucous membrane pemphigoid', 'punctate palmoplantar keratoderma type III', 'adrenal cortex carcinoma', 'alcoholic liver cirrhosis', 'atrophic gastritis', 'dental fluorosis', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'multiple system atrophy', 'myeloid sarcoma', 'nodular goiter', 'periapical granuloma', 'pulmonary edema', 'renovascular hypertension', 'retinopathy of prematurity', 'rheumatic heart disease', 'thromboangiitis obliterans', 'tooth disease', 'uremia', 'non-alcoholic steatohepatitis', 'Cryptogenic Organizing Pneumonia', 'Fascioliasis', 'Follicular Cyst', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Myocardial Ischemia', 'Pelvic Inflammatory Disease', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Pneumonia, Aspiration', 'Respiratory Syncytial Virus Infection', 'diabetic cardiomyopathy', 'diabetic foot', 'endothelial dysfunction', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'schistosomiasis', 'abortion', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'Bartsocas-Papas syndrome 1', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'SHOX-related short stature', 'intellectual disability, X-linked syndromic, Turner type', 'Fabry disease', 'X-linked corneal dermoid', 'Aarskog-Scott syndrome, X-linked', 'holoprosencephaly-hypokinesia-congenital contractures syndrome', 'Melnick-Needles syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'Wilson disease', 'adenomyosis', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'Ehlers-Danlos syndrome, musculocontractural type', 'tetrasomy 12p', 'sickle cell anemia', 'hypotonia-cystinuria syndrome', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'autoimmune lymphoproliferative syndrome type 2B', 'endometrial cancer', 'Loeys-Dietz syndrome 1', 'hyperinsulinemic hypoglycemia, familial, 4', 'preterm premature rupture of the membranes', 'Mungan syndrome', 'Crouzon syndrome-acanthosis nigricans syndrome', 'papillary renal cell carcinoma', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'pterygium', 'renal cell carcinoma', 'rheumatoid arthritis', 'sarcoma', 'severe acute respiratory syndrome', 'small cell lung carcinoma', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'spondyloarthropathy', 'stroke', 'subarachnoid hemorrhage', 'systemic scleroderma', 'ulcerative colitis', 'melanoma', 'hepatocellular adenoma', 'viral disease', 'HIV infection', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'pneumococcal infection', 'temporal lobe epilepsy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'malaria', 'folate deficiency', 'lung carcinoma', 'ovarian carcinoma', 'familial amyotrophic lateral sclerosis', 'pulmonary arterial hypertension', 'age-related macular degeneration', 'synovial sarcoma', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'villous adenoma', 'mucosal melanoma', 'ovarian clear cell cancer', 'central nervous system primitive neuroectodermal neoplasm', 'Crohn ileitis', 'vertebral column disorder', 'endometrial disorder', 'gastric cancer', 'penile cancer', 'myopia', 'pulmonary alveolar proteinosis', 'Chagas disease', 'leiomyoma', 'brain cancer', 'tuberous sclerosis', 'sick sinus syndrome', 'arteriovenous hemangioma/malformation', 'hypertensive heart disease', 'head and neck carcinoma', 'depressive disorder', 'pneumothorax', 'Richter syndrome', 'peritoneum cancer', 'thyroid cancer', 'disorder of sexual differentiation', 'vulvar melanoma', 'papilloma', 'rectosigmoid junction neoplasm', 'Treacher-Collins syndrome', 'prostatic acinar adenocarcinoma', 'gingival overgrowth', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratoma', 'bone inflammation disease', 'extraosseous osteosarcoma', 'chondroblastic osteosarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'lung benign neoplasm', 'skin cancer', 'cervical cancer', 'seminoma', 'breast angiosarcoma', 'cerebellar pilocytic astrocytoma', 'salivary gland adenoid cystic carcinoma', 'bile duct adenocarcinoma', 'gastroesophageal junction adenocarcinoma', 'thoracic cancer', 'acral lentiginous melanoma', 'endometrial mixed adenocarcinoma', 'female breast carcinoma', 'inflammation', 'erythrocyte volume', 'glomerular filtration rate', 'bone tissue density', 'progesterone amount', 'serum alanine aminotransferase amount', 'serum urea amount', 'serum creatinine amount', 'body height', 'cyst', 'Hypotonia - cystinuria syndrome', 'Chédiak-Higashi syndrome', 'Åland Islands eye disease', 'Hydrocephalus with stenosis of the aqueduct of Sylvius', 'Autoimmune lymphoproliferative syndrome with recurrent viral infections', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Persistent Müllerian duct syndrome', 'WHIM syndrome', 'Familial adenomatous polyposis', 'Other metabolic disease', 'hematocrit', 'C-reactive protein measurement', 'hematological measurement', 'alkaline phosphatase measurement', 'cryptorchidism', 'lymphocyte count', 'gestational diabetes', 'acute lung injury', 'serum gamma-glutamyl transferase measurement', 'HbA1c measurement', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'wet macular degeneration', 'insomnia', 'hypothyroidism', 'pelvic organ prolapse', 'metabolite measurement', 'eosinophil count', 'lymph node metastatic carcinoma', 'embryonal carcinoma', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'monocyte count', 'autoimmune disease', 'congenital heart disease', 'cholangiocarcinoma', 'human african trypanosomiasis', 'reading', 'congenital heart malformation', 'temporomandibular joint disorder', 'axial length measurement', 'myeloid leukemia', 'lupus erythematosus', 'allergic asthma', 'fatty liver disease', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'cataract', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'multiple sclerosis', 'skin basal cell carcinoma', 'brain glioma', 'colorectal cancer', 'Wilms tumor', 'Townes-Brocks syndrome', 'nevoid basal cell carcinoma syndrome', 'breast cancer', 'congenital contractural arachnodactyly', 'Duane retraction syndrome', 'dyschromatosis symmetrica hereditaria', 'metastatic malignant neoplasm', 'Loeys-Dietz syndrome 6', 'cervical squamous intraepithelial neoplasia', 'leukoplakia', 'spinal cord injury', 'ulcer disease', 'desmoplastic melanoma', 'myelofibrosis', 'oral cavity carcinoma', 'rectal carcinoma', 'hydrocephalus, congenital, 3, with brain anomalies', 'nasal cavity and paranasal sinus carcinoma', 'COVID-19', 'Dravet syndrome', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'achalasia-alacrima syndrome', 'metabolic bone disorder', 'congenital heart defects, multiple types, 8, with or without heterotaxy', 'postmenopausal osteoporosis', 'intestinal polyp', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'breast neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'stomach neoplasm', 'ankylosing spondylitis', 'ciliopathy', 'deep vein thrombosis', 'obstructive sleep apnea', 'necrotizing enterocolitis', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'atherosclerosis', 'open-angle glaucoma', 'androgenetic alopecia', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'focal segmental glomerulosclerosis', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'myeloproliferative disorder', 'nephrotic syndrome', 'vascular disease', 'thoracic aortic aneurysm', 'venous thromboembolism', 'platelet count', 'body mass index', 'neuroimaging measurement', 'metastatic neoplasm', 'whole body water mass', 'kidney injury', 'bone metastasis', 'gastrointestinal disease', 'aspartate aminotransferase to alanine aminotransferase ratio', 'urea measurement', 'viral load', '2-hydroxyacetaminophen sulfate measurement', 'aging', 'serum lipopolysaccharide activity', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'ependymoma', 'granulosa cell tumor', 'metaplastic breast carcinoma', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'ACTH-Producing Pituitary Gland Adenoma', 'Adenomatoid Odontogenic Tumor', 'Ampulla of Vater Carcinoma', 'Anal Squamous Cell Carcinoma', 'Anaplastic (Malignant) Meningioma', 'Appendix Adenocarcinoma', 'Appendix Goblet Cell Carcinoid', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Breast Carcinoma by Gene Expression Profile', 'cervical squamous cell carcinoma', 'Columnar Cell Hyperplasia of the Breast', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Extramammary Paget Disease', 'fibrodysplasia ossificans progressiva', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'Pallister-Hall syndrome', 'Nager acrofacial dysostosis', 'Marfan syndrome', 'Cowden syndrome 1', 'nail-patella syndrome', 'ovarian cancer', 'Andersen-Tawil syndrome', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'nonpapillary renal cell carcinoma', 'Mobius syndrome', 'Peyronie disease', 'prostate cancer', 'retinoblastoma', 'acrodermatitis enteropathica', 'mitochondrial DNA depletion syndrome 4a', 'Alstrom syndrome', 'anencephaly 1', 'microphthalmia with limb anomalies', 'Bloom syndrome', 'lung cancer', 'cerebrotendinous xanthomatosis', 'cystic fibrosis', 'recessive dystrophic epidermolysis bullosa', 'Haim-Munk syndrome', 'Laurence-Moon syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'ischemic cardiomyopathy', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'fibrosarcoma', 'hypertrophy', 'actinic keratosis', 'anaplastic astrocytoma', 'anaplastic oligodendroglioma', 'cardiac hypertrophy', 'AIDS dementia', 'pancreatic carcinoma', 'prostate intraepithelial neoplasia', 'thyroid carcinoma', 'insulin resistance', 'esophageal carcinoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'acute megakaryoblastic leukaemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'pleomorphic liposarcoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'Pick disease', 'testicular seminoma', 'osteomyelitis', 'spina bifida', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'lung disease', 'dental caries', 'serous adenocarcinoma', 'retinopathy', 'adrenal gland neoplasm'], tissue_specific_expression={'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\"small intestine Peyer's patch\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}, is_essential=False, genetic_constraint={'syn': 0.11195000261068344, 'mis': 4.47730016708374, 'lof': 1.0}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.', '*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett\\\\'s esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'frontal lobe\\\\': -1, \\\\'endothelial cell of umbilical vein (resting)\\\\': 2, \\\\'zone of skin\\\\': 0, \\\\'regulatory T cell\\\\': 1, \\\\'pancreas\\\\': -1, \\\\'suprapubic skin\\\\': -1, \\\\'temporal lobe\\\\': -1, \\\\'parathyroid gland\\\\': -1, \\\\'spleen\\\\': -1, \\\\'Brodmann (1909) area 9\\\\': -1, \\\\'breast\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': -1, \\\\'alternatively activated macrophage\\\\': 2, \\\\'segmented neutrophil of bone marrow\\\\': 4, \\\\'placenta\\\\': -1, \\\\'mature eosinophil\\\\': 1, \\\\'granulocyte monocyte progenitor cell\\\\': 0, \\\\'gall bladder\\\\': -1, \\\\'esophagus muscularis mucosa\\\\': -1, \\\\'seminal vesicle\\\\': -1, \\\\'endocervix\\\\': -1, \\\\'lower leg skin\\\\': -1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 2, \\\\'CD8-positive, alpha-beta T cell\\\\': 3, \\\\'cerebral cortex\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': 4, \\\\'hippocampus proper\\\\': -1, \\\\'uterus\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': 3, \\\\'tonsil\\\\': -1, \\\\'esophagus\\\\': 0, \\\\'transverse colon\\\\': -1, \\\\'pituitary gland\\\\': -1, \\\\'coronary artery\\\\': -1, \\\\'memory B cell\\\\': 0, \\\\'sigmoid colon\\\\': -1, \\\\'cerebellum\\\\': -1, \\\\'erythroblast\\\\': 2, \\\\'prefrontal cortex\\\\': -1, \\\\'nucleus accumbens\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'vermiform appendix\\\\': -1, \\\\'greater omentum\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': 1, \\\\'leukocyte\\\\': 2, \\\\'adrenal gland\\\\': -1, \\\\'atrium auricular region\\\\': -1, \\\\'thyroid gland\\\\': 0, \\\\'tibial artery\\\\': -1, \\\\'common lymphoid progenitor\\\\': 3, \\\\'urinary bladder\\\\': -1, \\\\'duodenum\\\\': -1, \\\\'heart muscle\\\\': -1, \\\\'small intestine\\\\': -1, \\\\'neutrophilic metamyelocyte\\\\': 3, \\\\'minor salivary gland\\\\': -1, \\\\'rectum\\\\': 0, \\\\'ovary\\\\': -1, \\\\'substantia nigra\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': -1, \\\\'class switched memory B cell\\\\': 1, \\\\'fallopian tube\\\\': -1, \\\\'esophagus mucosa\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 0, \\\\'bronchus\\\\': -1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": -1, \\\\'kidney\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'macrophage\\\\': 1, \\\\'aorta\\\\': -1, \\\\'skeletal muscle tissue\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': 4, \\\\'caudate-putamen\\\\': -1, \\\\'liver\\\\': -1, \\\\'cytotoxic CD56-dim natural killer cell\\\\': 2, \\\\'mature neutrophil\\\\': 2, \\\\'hypothalamus\\\\': -1, \\\\'transformed skin fibroblast\\\\': -1, \\\\'bone marrow\\\\': -1, \\\\'inflammatory macrophage\\\\': 0, \\\\'cortex of kidney\\\\': -1, \\\\'lung\\\\': -1, \\\\'epididymis\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'saliva-secreting gland\\\\': -1, \\\\'nasopharynx\\\\': -1, \\\\'colon\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'stomach\\\\': -1, \\\\'testis\\\\': -1, \\\\'smooth muscle tissue\\\\': 0, \\\\'putamen\\\\': -1, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 5, \\\\'C1 segment of cervical spinal cord\\\\': 0, \\\\'blood\\\\': -1, \\\\'hematopoietic stem cell\\\\': 1, \\\\'caudate nucleus\\\\': -1, \\\\'amygdala\\\\': -1, \\\\'brain\\\\': 0, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'ectocervix\\\\': -1, \\\\'prostate gland\\\\': -1, \\\\'conventional dendritic cell\\\\': 4, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'heart left ventricle\\\\': -1, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 0, \\\\'vagina\\\\': -1, \\\\'esophagogastric junction\\\\': -1, \\\\'lymph node\\\\': -1, \\\\'endometrium\\\\': -1, \\\\'heart\\\\': -1, \\\\'oral mucosa\\\\': -1, \\\\'CD8-positive, alpha-beta thymocyte\\\\': 4, \\\\'common myeloid progenitor\\\\': 0, \\\\'tibial nerve\\\\': -1, \\\\'plasma cell\\\\': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id='P84022', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'], diseases=['Colorectal cancer', 'Loeys-Dietz syndrome 3'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['BAG3', 'HIF1A', 'SMAD2', 'SMAD4', 'SMURF1', 'SMURF2', 'SP1'], 'Affinity Capture-MS': ['ARID1A', 'ATG14', 'ATG16L1', 'ATXN2L', 'BUB3', 'C1ORF116', 'CD6', 'CDK11A', 'CHD8', 'CIC', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DCAF4', 'DCAF7', 'DDX3X', 'DDX3Y', 'DDX4', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'DZIP3', 'EPB41L5', 'ERBB2IP', 'EVA1B', 'EZH2', 'FAM83G', 'FURIN', 'HINT3', 'HSPA4', 'IRF7', 'IRS1', 'ITGB4', 'KAT6A', 'KCTD16', 'LACRT', 'LDLRAD4', 'LEMD3', 'LRCH1', 'LSR', 'MAP2K3', 'MAPK1', 'MED16', 'MED4', 'NCOA3', 'NF2', 'OPA1', 'OTUB1', 'OTUD1', 'PABPC1', 'PARK2', 'PJA1', 'PLEKHA4', 'PPIE', 'PRNP', 'PSPC1', 'PTPN6', 'RAB11FIP5', 'RPL3', 'RPL4', 'RPSAP15', 'SIK3', 'SLC25A12', 'SLC9A3R2', 'SMAD1', 'SMAD2', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMURF2', 'SNW1', 'SQRDL', 'SUZ12', 'TAF1', 'TAF2', 'TCP1', 'TGFB1', 'TMEM192', 'TRIM33', 'TRIM67', 'TRIP4', 'U2AF2', 'UGT1A10', 'USP33', 'USP7', 'VAV2', 'WWP2', 'YTHDF2', 'YY1', 'ZFP69B', 'ZFYVE9', 'ZRANB1'], 'Affinity Capture-RNA': ['DDX58', 'TRIM25'], 'Affinity Capture-Western': ['ACTB', 'ACVR1B', 'AKT1', 'ANAPC10', 'AR', 'ATF2', 'ATF3', 'BACH1', 'BRCA1', 'BRCA2', 'BTRC', 'CBL', 'CDC16', 'CDC25A', 'CDC27', 'CDKN1A', 'CEBPD', 'CHRD', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CSNK1G2', 'CTCF', 'CTNNB1', 'CUL1', 'DAB2', 'DACH1', 'DEDD', 'DOCK9', 'E2F4', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXL2', 'FOXM1', 'FOXO1', 'FOXO3', 'FOXO4', 'GRIP1', 'GSK3B', 'HDAC4', 'HDAC5', 'HGS', 'HIF1A', 'HNF4A', 'HYAL2', 'ID1', 'IRF7', 'JUN', 'KAT2A', 'KAT2B', 'KAT6A', 'KDM5C', 'KDM6B', 'KLF5', 'KPNB1', 'LEF1', 'MAFK', 'MECOM', 'MED15', 'MED24', 'MED6', 'MEN1', 'METTL14', 'METTL3', 'MKL1', 'MYC', 'MYD88', 'MYOCD', 'NCOA1', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIC', 'NFYC', 'NOTCH1', 'NOTCH4', 'NR3C1', 'NR4A1', 'NUP214', 'OTUB1', 'OTUD1', 'OVOL2', 'PAX6', 'PCK2', 'PDLIM5', 'PIAS3', 'PIAS4', 'PIN1', 'PITX1', 'PITX2', 'PML', 'PPARG', 'PPP1R12C', 'PRDM16', 'PRTN3', 'RARA', 'RBBP5', 'RBL1', 'RBX1', 'RELB', 'RGCC', 'RNF111', 'RNF31', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SETD2', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD7', 'SMARCA4', 'SMARCC2', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'SQSTM1', 'SREBF2', 'SRY', 'STRAP', 'STUB1', 'SUV39H1', 'TCF12', 'TGFB1I1', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TGIF2', 'TOB1', 'TP53', 'TRIB3', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'TSC22D4', 'UCHL1', 'UCHL5', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWOX', 'WWP1', 'WWP2', 'YAP1', 'ZC3H12A', 'ZEB1', 'ZEB2', 'ZFYVE9', 'ZMIZ1'], 'Biochemical Activity': ['CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'CSNK1G2', 'MAPK1', 'NEDD4', 'NEDD4L', 'OTUB1', 'TGFBR1', 'USP15', 'USP7', 'WWP2'], 'Co-crystal Structure': ['SMAD3', 'SMAD4', 'ZFYVE9'], 'Co-fractionation': ['ALKBH2', 'ANAPC10', 'APP', 'ARID1B', 'CDH1', 'CREBBP', 'CTCF', 'CTNNB1', 'CUL1', 'DDR1', 'FOXO3', 'HDAC1', 'HMGA2', 'IGF1R', 'ITGB1', 'JUND', 'MTA2', 'NAA15', 'NT5DC3', 'PARP1', 'PRKDC', 'RBM14', 'RBX1', 'RELA', 'RIPK1', 'RNMT', 'SIN3A', 'SKP1', 'SMAD2', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SP1', 'SUB1', 'TRIM33', 'XRCC5', 'XRCC6', 'ZFHX3', 'ZFYVE9'], 'Co-localization': ['AKT1', 'BMP7', 'CAMK2G', 'CDK2', 'CDK4', 'EPAS1', 'ETS1', 'FOXO3', 'HIF1A', 'IRF7', 'MAP3K7', 'MAPK8', 'MAX', 'TP53', 'TRIM62'], 'Cross-Linking-MS (XL-MS)': ['RPL10A'], 'FRET': ['SMAD4', 'STUB1'], 'PCA': ['SMAD4', 'SMAD7'], 'Phenotypic Enhancement': ['HIF1A', 'SMAD2', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['JAK1'], 'Protein-RNA': ['LINC00941'], 'Protein-peptide': ['CREBBP', 'FOXH1', 'ITCH', 'LEF1', 'NEDD4', 'PIN1'], 'Proximity Label-MS': ['NFIA'], 'Reconstituted Complex': ['ANAPC10', 'APP', 'AR', 'ATF2', 'ATF3', 'BPTF', 'BRCA1', 'BRCA2', 'CEBPA', 'CEBPB', 'CEBPD', 'CITED2', 'CREBBP', 'CTCF', 'DAB2', 'DDX5', 'DEDD', 'DNMT3L', 'DVL1', 'E2F4', 'EID2', 'EIF4B', 'EP300', 'ERBB2IP', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXM1', 'GSK3B', 'HDAC1', 'HDAC4', 'HDAC5', 'HIF1A', 'HIPK2', 'HNF4A', 'HYAL2', 'IRF7', 'ITCH', 'JUN', 'JUNB', 'JUND', 'KAT2B', 'KAT6A', 'KPNB1', 'LCK', 'LEF1', 'LEMD3', 'MAX', 'MDM4', 'MECOM', 'MYC', 'MYOCD', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIA', 'NOTCH1', 'NR3C1', 'NUP153', 'NUP214', 'PARD3', 'PIAS2', 'PIAS3', 'PIAS4', 'PIK3CA', 'PIN1', 'RBL1', 'RUNX2', 'S100A4', 'SH2D2A', 'SIN3A', 'SKI', 'SKIL', 'SMAD3', 'SMAD4', 'SMURF2', 'SNW1', 'SP1', 'STUB1', 'TFE3', 'TGFB1I1', 'TGFBR1', 'TGIF1', 'TP53', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'UCHL5', 'USP15', 'VDR', 'WWOX', 'XPO6', 'YY1', 'ZFYVE9', 'ZMIZ1'], 'Two-hybrid': ['AATF', 'AES', 'ANK3', 'APMAP', 'APOB', 'AR', 'ATF2', 'BLZF1', 'C10ORF54', 'C14ORF105', 'CCDC33', 'CDC25A', 'CFDP1', 'CFH', 'CFLAR', 'CHRD', 'CORO1A', 'CPSF7', 'CPTP', 'CREBBP', 'CRX', 'CSH2', 'CXXC5', 'CYP11A1', 'DEDD', 'DNAJB4', 'DNAJB5', 'EBI3', 'EP300', 'EPAS1', 'FAM90A1', 'FBLN1', 'FLI1', 'FLNA', 'FOS', 'FOXH1', 'GGA1', 'GIT2', 'GMEB1', 'HDAC1', 'HEY1', 'HEYL', 'HIF1A', 'HIVEP1', 'HNRNPK', 'HOXC11', 'HP', 'ISL1', 'JUN', 'JUNB', 'KANSL1', 'KDM2A', 'KMT2B', 'LBP', 'MCM3AP', 'MEOX2', 'MTF2', 'MYC', 'MYD88', 'NCOA6', 'NEDD4', 'NEDD9', 'NR4A1', 'PAPPA', 'PARP4', 'PCDH1', 'PCK2', 'PHC2', 'PIAS4', 'PIN1', 'PLAG1', 'PLAGL1', 'PLG', 'PPP1R12C', 'PPP2R1A', 'PRDM4', 'PROX1', 'PSMB1', 'PSMD11', 'RANBP9', 'RBPMS', 'RBX1', 'RCVRN', 'RELA', 'RIOK2', 'RNF31', 'RPA1', 'RPLP0', 'SAP130', 'SBK3', 'SERTAD1', 'SETD2', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMURF1', 'SMURF2', 'SNRNP70', 'SNW1', 'SP1', 'SQSTM1', 'SS18L1', 'ST6GALNAC2', 'SVEP1', 'TANK', 'TDP2', 'TEKT4', 'TF', 'TGM2', 'TLR4', 'TMED1', 'TSC22D4', 'UBQLN4', 'USP7', 'VDR', 'WWP1', 'WWP2', 'XRCC6', 'ZBTB16', 'ZBTB3', 'ZC3H12A', 'ZCCHC14', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF329', 'ZNF774', 'ZNF83']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF6', 'ARHGEF7', 'CLASRP', 'FBXO3', 'GSC', 'MAP2K3', 'PPP2R2D', 'RAB38', 'RASD2', 'RGS3', 'RRAS2', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'WEE1', 'WWP2'], 'Affinity Capture-MS': ['ATG16L1', 'E6', 'NSP6', 'OTUB1', 'SMAD3'], 'Affinity Capture-Western': ['AXIN1', 'COL1A1', 'COL3A1', 'COL5A1', 'DDX5', 'DOK1', 'E6', 'E7', 'EP300', 'GATA4', 'GNB2L1', 'HCVGP1', 'HDAC4', 'KLF4', 'MED15', 'MELK', 'N', 'RNF111', 'SKI', 'SMAD3', 'SMAD3A', 'SMAD4', 'TGFB1I1', 'TOB1', 'TOB1A', 'TOB1B', 'VDR', 'ZEB1'], 'Co-localization': ['E7', 'N'], 'PCA': ['E6'], 'Phenotypic Enhancement': ['SMAD3A'], 'Phenotypic Suppression': ['SMAD3A'], 'Proximity Label-MS': ['M'], 'Reconstituted Complex': ['E6', 'E7', 'GATA4', 'N', 'SIN3A', 'SMAD3', 'SOX9', 'YAP1', 'ZFP128'], 'Synthetic Growth Defect': ['MMP9'], 'Two-hybrid': ['DVL1', 'E6', 'ERBB2IP', 'FOXH1', 'GATA4', 'HCVGP1', 'JUN', 'MAGI2', 'PARD3', 'SMAD3', 'ZEB2']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Large for gestational age', 'Alopecia', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Right ventricular hypertrophy', 'Myocardial fibrosis', 'Hallux valgus', 'Increased total eosinophil count', 'Acute kidney injury', 'Renal artery stenosis', 'Hypoglycemia', 'Glucose intolerance', 'Abnormal thrombosis', 'Rectal prolapse', 'Esophageal stricture', 'Pulmonary hypoplasia', 'Asthma', 'Cerebral cortical atrophy', 'Ischemic stroke', 'Aortic root aneurysm', 'Aortic dissection', 'Spontaneous pneumothorax', 'Vascular dilatation', 'Cerebral ischemia', 'Immunodeficiency', 'Systemic lupus erythematosus', 'Oral leukoplakia', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Back pain', 'Muscular dystrophy', 'Hernia of the abdominal wall', 'Cachexia', 'Ascending aortic dissection', 'Venous thrombosis', 'Ascending tubular aorta aneurysm', 'Ureteral obstruction', 'Airway obstruction', 'Pituitary prolactin cell adenoma', 'Premature ovarian insufficiency', 'Intervertebral disk degeneration', 'Lipodystrophy', 'Hamartoma', 'Chordoma', 'Stress urinary incontinence', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Urethral stricture', 'Allergy', 'Renal atrophy', 'Pulmonary bulla', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Hernia', 'Sepsis', 'Skin ulcer', 'Left ventricular dilatation', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'adolescent idiopathic scoliosis', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'gamma chain deficiency', 'seborrheic keratosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'smoking initiation', 'Staphylococcus aureus infection', 'rheumatic disease', 'lupus nephritis', 'pulse pressure measurement', 'neurodegenerative disease', 'retinal detachment', 'Autoimmune Hepatitis', 'non-high density lipoprotein cholesterol measurement', 'brain disease', 'aortic disease', 'neonatal abstinence syndrome', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'non-Hodgkins lymphoma', 'breast ductal adenocarcinoma', 'systolic blood pressure', 'diastolic blood pressure', 'pulmonary artery enlargement', 'laryngeal squamous cell carcinoma', 'cystadenocarcinoma', 'ovarian mucinous adenocarcinoma', 'smoking status measurement', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'cerebral amyloid angiopathy', 'autoimmune thyroid disease', 'stricture', 'head and neck malignant neoplasia', 'urgency urinary incontinence', 'fibrosis', 'diastolic blood pressure change measurement', 'drug use measurement', 'allergic conjunctivitis', 'aortic valve insufficiency', 'Balkan nephropathy', 'bronchiolitis obliterans', 'congenital rubella', 'coronavirus infectious disease', 'echinococcosis', 'endodermal sinus tumor', 'Gerstmann syndrome', 'Guillain-Barre syndrome', 'influenza', 'intestinal cancer', 'legionellosis', 'lymphatic system disease', 'male reproductive organ cancer', 'aneurysm-osteoarthritis syndrome', 'autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome', 'hyperuricemic nephropathy, familial juvenile type 3', 'graft versus host disease', 'autoimmune lymphoproliferative syndrome type 4', 'combined immunodeficiency due to LRBA deficiency', 'adenine phosphoribosyltransferase deficiency', 'karyomegalic interstitial nephritis', 'dyskeratosis congenita, autosomal recessive 5', 'TCR-alpha-beta-positive T-cell deficiency', 'severe combined immunodeficiency due to IKK2 deficiency', 'immunodeficiency 18', 'immunodeficiency 23', 'severe combined immunodeficiency due to CTPS1 deficiency', 'severe neurodegenerative syndrome with lipodystrophy', 'periodic fever-infantile enterocolitis-autoinflammatory syndrome', 'immunodeficiency 37', 'chronic atrial and intestinal dysrhythmia', 'DOCK2 deficiency', 'DDX41-related hematologic malignancy predisposition syndrome', 'fibrochondrogenesis 2', 'C3 glomerulonephritis', 'agammaglobulinemia 7, autosomal recessive', 'autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency', 'infantile-onset periodic fever-panniculitis-dermatosis syndrome', 'lung disease, immunodeficiency, and chromosome breakage syndrome;', 'neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade', 'chronic diarrhea due to glucoamylase deficiency', 'Bardet-Biedl syndrome', 'familial pancreatic carcinoma', 'nasopharyngeal carcinoma', 'craniosynostosis', 'keratoconus', 'common variable immunodeficiency', 'hyperplastic polyposis syndrome', 'dentin dysplasia', 'T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'qualitative or quantitative defects of dysferlin', 'holoprosencephaly', 'attenuated familial adenomatous polyposis', 'isolated agammaglobulinemia', 'pachyonychia congenita', 'familial hyperaldosteronism', 'hypohidrotic ectodermal dysplasia', 'primary ciliary dyskinesia', 'APC-related attenuated familial adenomatous polyposis', 'meningioma', 'multiple epiphyseal dysplasia', 'hemangioblastoma', 'Moyamoya disease', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'IgG4-related disease', 'juvenile polyposis syndrome', 'pituitary tumor', 'ameloblastoma', 'exstrophy-epispadias complex', 'autoimmune lymphoproliferative syndrome', 'syringomyelia', 'selective IgM deficiency', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', 'congestive heart failure', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'embryonal rhabdomyosarcoma', 'emphysema', 'epilepsy', 'fetal growth restriction', 'ganglioneuroma', 'gastric adenocarcinoma', 'esophageal adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'glioblastoma multiforme', 'hypertension', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'tuberculosis', 'glioblastoma', 'chronic granulomatous disease', 'liver mesenchymal hamartoma', 'activated PI3K-delta syndrome', 'carcinoma of liver and intrahepatic biliary tract', 'cutaneous polyarteritis nodosa', 'hereditary nonpolyposis colon cancer', 'Polymerase proofreading-related adenomatous polyposis', 'Zika virus infectious disease', 'regressive spondylometaphyseal dysplasia', 'Jeune syndrome', 'Li-Fraumeni syndrome', 'posterior cortical atrophy', '22q11.2 deletion syndrome', 'Loeys-Dietz syndrome', 'congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization', 'intrahepatic cholestasis', 'bronchopulmonary dysplasia', 'Hirschsprung disease', 'mucinous adenocarcinoma of the appendix', 'Lhermitte-Duclos disease', 'sarcoidosis', 'peeling skin syndrome', 'Fanconi anemia', 'dysspondyloenchondromatosis', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'acute liver failure', 'discoid lupus erythematosus', 'familial thoracic aortic aneurysm and aortic dissection', 'renal hypoplasia', 'renal dysplasia', 'spondyloepiphyseal dysplasia tarda', 'ulnar hemimelia', 'radial hemimelia', 'growth hormone-producing pituitary gland neoplasm', 'encephalitis', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'autosomal dominant cerebellar ataxia', 'precursor B-cell acute lymphoblastic leukemia', 'chronic graft versus host disease', 'superficial spreading melanoma', 'renal pelvis/ureter urothelial carcinoma', 'tubulointerstitial kidney disease, autosomal dominant, 2', 'lung neoplasm', 'intestinal neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'neoplasm of esophagus', 'tumor of parathyroid gland', 'polyp of colon', 'low grade glioma', 'coronary atherosclerosis', 'gram-negative bacterial infections', 'sexually transmitted disease', 'radiculitis', 'viral myocarditis', 'lip and oral cavity carcinoma', 'immunodeficiency 14b, autosomal recessive', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'respiratory tract infectious disorder', 'chondrogenic neoplasm', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'synucleinopathy', 'pulmonary sarcoidosis', 'gonorrhea', 'chronic lymphocytic leukemia', 'neoplasm of mature B-cells', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'metastatic prostate cancer', 'T-cell acute lymphoblastic leukemia', 'unspecified peripheral T-cell lymphoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'oral squamous cell carcinoma', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'adenocarcinoma', 'adenoma', 'adenosquamous lung carcinoma', 'adrenal gland pheochromocytoma', 'alveolar rhabdomyosarcoma', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', 'benign prostatic hyperplasia', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'Burkitts lymphoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'chondrosarcoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'chronic pancreatitis', 'clear cell renal carcinoma', 'endometrial carcinoma', 'renal fibrosis', 'Adenomyosis', 'immunoproliferative small intestinal disease', 'Posterior Leukoencephalopathy Syndrome', 'amyloidosis', 'neuroendocrine neoplasm', 'Spinal cord injury', 'B-cell non-Hodgkins lymphoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'intrahepatic cholangiocarcinoma', 'pharyngeal squamous cell carcinoma', 'connective tissue disease', 'pneumonitis', 'Carcinoma, Lewis Lung', 'soft tissue sarcoma', 'adult onset asthma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'renal hypertension', 'glomerular disease', 'nephritis', 'positive regulation of ovulation', 'Neurogenic bladder', 'Inguinal hernia', 'Abnormality of the urinary system', 'Renal insufficiency', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Nephrocalcinosis', 'Uterine leiomyoma', 'Cleft palate', 'Retrognathia', 'Strabismus', 'Cataract', 'Proptosis', 'Myopia', 'Pectus excavatum', 'Infertility', 'Hematuria', 'Diabetes mellitus', 'Hyperinsulinemia', 'Insulin resistance', 'Abnormality of the skeletal system', 'Osteopenia', 'Osteoporosis', 'Jaundice', 'Eczematoid dermatitis', 'Global developmental delay', 'Stroke', 'Encephalopathy', 'Parkinsonism', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Cholestasis', 'Hepatic steatosis', 'Obesity', 'ornithine carbamoyltransferase deficiency', 'pseudomyxoma peritonei', 'silicosis', 'spinal stenosis', 'BMI-adjusted waist-hip ratio', 'BMI-adjusted waist circumference', 'body fat percentage', 'balding measurement', 'liver dysplastic nodule', 'wellbeing measurement', 'insomnia measurement', 'eosinophil percentage of leukocytes', 'eosinophil percentage of granulocytes', 'BMI-adjusted hip circumference', 'calf circumference measurement', 'chronic hepatitis', 'dysplasia', 'interstitial cystitis', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'oral lichen planus', 'rhinitis', 'small cell carcinoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'Hepatobiliary Neoplasm', 'acute myocardial infarction', 'peritonitis', 'pemphigus foliaceus', 'paraneoplastic pemphigus', 'cystic kidney disease', 'ovarian dysfunction', 'Arteritis', 'Polyarteritis Nodosa', 'arteriosclerosis', 'idiopathic dilated cardiomyopathy', 'hyperuricemia', 'female reproductive endometrioid cancer', 'skin carcinoma', 'heel bone mineral density', 'marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections', 'central nervous system disease', 'sum of eosinophil and basophil counts', 'lower respiratory tract disease', 'pulmonary fibrosis', 'infarction', 'corneal disease', 'vertebral joint disease', 'aortic valve disease', 'cervical disc degenerative disorder', 'hemorrhoid', 'mitral valve disease', 'feeling nervous measurement', 'stomach disease', 'myocarditis', 'aneurysm', 'laryngeal disease', 'musculoskeletal system disease', 'Gallbladder Adenocarcinoma', 'Gallbladder Adenoma', 'Gastric Neuroendocrine Tumor G1', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Mast Cell Sarcoma', 'Nasal Cavity Polyp', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Ovarian Granulosa Cell Tumor', 'Peritoneal Multicystic Mesothelioma', 'Pituitary Gland Adenoma', 'Placental Choriocarcinoma', 'Pleural Epithelioid Mesothelioma', 'Poorly Differentiated Thyroid Gland Carcinoma', 'Rectal Tubular Adenoma', 'Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions', 'Signet Ring Cell Gastric Adenocarcinoma', 'small intestinal adenocarcinoma', 'Spinal Chordoma', 'Testicular Embryonal Carcinoma', 'Thyroid Gland Oncocytic Follicular Carcinoma', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vaginal Melanoma', 'hamartoma', 'acute respiratory distress syndrome', 'rectum cancer', 'acanthosis nigricans', 'cholesteatoma', 'Primary Pulmonary Diffuse Large B-Cell Lymphoma', 'developmental dysplasia of the hip', 'sarcopenia', 'mucous membrane pemphigoid', 'osteoarthritis, hip', 'osteoarthritis, spine', 'adrenal cortex carcinoma', 'adrenal gland hyperfunction', 'alcoholic cardiomyopathy', 'aortitis', 'atrial heart septal defect', 'causalgia', 'coronary aneurysm', 'diastolic heart failure', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'joint disease', 'lipoid nephrosis', 'mouth disease', 'multiple system atrophy', 'myeloid sarcoma', 'ocular hypertension', 'parathyroid adenoma', 'proliferative vitreoretinopathy', 'pulmonary edema', 'pulpitis', 'Raynaud disease', 'renovascular hypertension', 'rheumatic heart disease', 'Schnitzler syndrome', 'thromboangiitis obliterans', 'ulcerative proctosigmoiditis', 'uremia', 'non-alcoholic steatohepatitis', 'rotator cuff tear', 'Anemia, Hemolytic, Autoimmune', 'Cardiac Tamponade', 'End Stage Liver Disease', 'Endometritis', 'Escherichia coli Infections', 'Genital neoplasm, female', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Lentivirus Infections', 'Myocardial Ischemia', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Tularemia', 'diabetic cardiomyopathy', 'endothelial dysfunction', 'gliosarcoma', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'metastatic colorectal cancer', 'enterocolitis', 'primary biliary cirrhosis', 'abortion', 'psoriasis vulgaris', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'primary hyperoxaluria type 2', 'hyperimmunoglobulinemia D with periodic fever', 'autosomal recessive polycystic kidney disease', 'Senior-Loken syndrome 1', 'reticular dysgenesis', 'schneckenbecken dysplasia', 'combined immunodeficiency due to ZAP70 deficiency', 'familial isolated congenital asplenia', 'brachyolmia type 1, Hobaek type', 'brachyolmia type 1, toledo type', 'spondyloperipheral dysplasia', 'thoracomelic dysplasia', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'Wilson disease', 'X-linked spondyloepimetaphyseal dysplasia', 'hypoxanthine guanine phosphoribosyltransferase partial deficiency', 'Bruton-type agammaglobulinemia', 'X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia', 'combined immunodeficiency due to moesin deficiency', 'Wiskott-Aldrich syndrome', 'Aarskog-Scott syndrome, X-linked', 'hyper-IgM syndrome type 1', 'Melnick-Needles syndrome', 'Bartsocas-Papas syndrome 1', 'pulmonary venoocclusive disease', 'spondyloepimetaphyseal dysplasia, Irapa type', 'SHOX-related short stature', 'immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'spondyloepiphyseal dysplasia tarda, X-linked', 'T-B+ severe combined immunodeficiency due to JAK3 deficiency', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'skeletal dysplasia-epilepsy-short stature syndrome', 'hereditary mixed polyposis syndrome', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive', 'Ehlers-Danlos syndrome, musculocontractural type', 'spondyloepimetaphyseal dysplasia, Missouri type', 'axial spondylometaphyseal dysplasia', 'severe combined immunodeficiency due to DCLRE1C deficiency', 'spondyloepimetaphyseal dysplasia, Shohat type', 'myotonic dystrophy type 2', 'radioulnar synostosis-microcephaly-scoliosis syndrome', 'spondyloepimetaphyseal dysplasia with multiple dislocations', 'Omenn syndrome', 'xanthinuria type II', 'autoimmune lymphoproliferative syndrome type 2A', 'nephronophthisis 3', 'pyogenic arthritis-pyoderma gangrenosum-acne syndrome', 'hyper-IgM syndrome type 2', 'immunodeficiency due to CD25 deficiency', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'hyper-IgM syndrome type 3', 'multiple epiphyseal dysplasia type 5', 'anauxetic dysplasia', 'autoimmune lymphoproliferative syndrome type 2B', 'Smith-McCort dysplasia 1', 'granular corneal dystrophy type II', 'acrocapitofemoral dysplasia', 'endometrial cancer', 'hyper-IgM syndrome type 5', 'hyper-IgM syndrome type 4', 'neutrophil immunodeficiency syndrome', 'familial adenomatous polyposis 2', 'spondyloepimetaphyseal dysplasia, matrilin-3 type', 'familial avascular necrosis of femoral head', 'immunodeficiency 104', 'spondylometaphyseal dysplasia, A4 type', 'epidermolysis bullosa simplex 7, with nephropathy and deafness', 'permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome', 'mesoaxial synostotic syndactyly with phalangeal reduction', 'hyperinsulinemic hypoglycemia, familial, 4', 'Mungan syndrome', 'familial cold autoinflammatory syndrome 2', 'aortic aneurysm, familial thoracic 6', 'hypouricemia, renal, 2', 'dopa-responsive dystonia due to sepiapterin reductase deficiency', 'combined immunodeficiency due to STIM1 deficiency', 'atypical hemolytic-uremic syndrome with MCP/CD46 anomaly', 'atypical hemolytic-uremic syndrome with I factor anomaly', 'atypical hemolytic-uremic syndrome with B factor anomaly', 'atypical hemolytic-uremic syndrome with C3 anomaly', 'atypical hemolytic-uremic syndrome with thrombomodulin anomaly', 'lymphoproliferative syndrome 1', 'purine nucleoside phosphorylase deficiency', 'spondylo-megaepiphyseal-metaphyseal dysplasia', 'brachydactylous dwarfism, Mseleni type', 'spondyloepimetaphyseal dysplasia, Handigodu type', 'hemolytic anemia due to glucophosphate isomerase deficiency', 'alpha 1-antitrypsin deficiency', 'occult macular dystrophy', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'polyp', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'renal cell carcinoma', 'respiratory system disease', 'sarcoma', 'severe acute respiratory syndrome', 'Sjogren syndrome', 'skin disease', 'small cell lung carcinoma', 'rheumatoid arthritis', 'spindle cell tumor', 'spondyloarthropathy', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'systemic scleroderma', 'ulcerative colitis', 'uterine fibroid', 'melanoma', 'malignant peripheral nerve sheath tumor', 'viral disease', 'HIV infection', 'AIDS', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'temporal lobe epilepsy', 'myositis', 'leprosy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'Down syndrome', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'lung carcinoma', 'ovarian carcinoma', 'post-traumatic stress disorder', 'pulmonary arterial hypertension', 'synovial sarcoma', 'autosomal dominant polycystic liver disease', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'small intestinal neuroendocrine tumor G1', 'breast benign neoplasm', 'central nervous system primitive neuroectodermal neoplasm', 'vertebral column disorder', 'cerebral cavernous malformation', 'interstitial emphysema', 'gastric cancer', 'essential hypertension', 'hypertensive heart disease', 'familial hyperlipidemia', 'impaired renal function disease', 'myopia', 'nephrocalcinosis', 'leiomyoma', 'prolapse of female genital organ', 'brain cancer', 'nontoxic goiter', 'pure red-cell aplasia', 'crescentic glomerulonephritis', 'tuberous sclerosis', 'depressive disorder', 'ventricular septal defect', 'pneumothorax', 'Richter syndrome', 'thyroid cancer', 'giant cell tumor', 'spondylosis', 'papilloma', 'kidney cancer', 'dermatitis', 'prostatic adenoma', 'lobular neoplasia', 'gingival overgrowth', 'papillary adenocarcinoma', 'digestive system cancer', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratocarcinoma', 'teratoma', 'bone inflammation disease', 'small cell osteogenic sarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'anal canal adenocarcinoma', 'skin cancer', 'cerebellar neoplasm', 'cervical cancer', 'breast angiosarcoma', 'bile duct adenocarcinoma', 'thoracic cancer', 'colonic disorder', 'functioning pituitary gland adenoma', 'anal canal squamous cell carcinoma', 'pancreatic intraductal papillary-mucinous neoplasm', 'muscular atrophy', 'female breast carcinoma', 'retinal degeneration', 'MHC class II deficiency 4', 'immunodeficiency 122', 'inflammation', 'circulating fibrinogen levels', 'glomerular filtration rate', 'fat pad mass', 'hip circumference', 'bone tissue density', 'von Willebrand factor quality', 'waist circumference', 'age of onset of asthma', 'level of serum globulin type protein', 'red blood cell density', 'serum alanine aminotransferase amount', 'heart rate', 'age of onset of allergic disease', 'brain volume', 'serum albumin amount', 'serum creatinine amount', 'body height', 'cyst', 'X-linked hyper-IgM syndrome', 'Brachydactyly - elbow wrist dysplasia', 'Chronic mucocutaneous candidosis', 'Desbuquois syndrome', 'Chédiak-Higashi syndrome', 'Recurrent infection due to specific granule deficiency', 'Immunodeficiency syndrome with autoimmunity', 'Metaphyseal chondrodysplasia, Schmid type', 'Åland Islands eye disease', 'Ichthyosis - intellectual disability - dwarfism - renal impairment', 'Autosomal recessive early-onset inflammatory bowel disease', 'X-linked lymphoproliferative disease', 'Metaphyseal dysostosis - intellectual disability - conductive deafness', 'CHST3-related skeletal dysplasia', 'Cyclic neutropenia', 'Severe combined immunodeficiency due to adenosine deaminase deficiency', 'Aneurysm - osteoarthritis syndrome', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Multiple osteochondromas', 'Recurrent infections-myelofibrosis-nephromegaly syndrome', 'Acromesomelic dysplasia, Maroteaux type', 'Hyperlipoproteinemia type 1', 'X-linked agammaglobulinemia', 'Familial hemophagocytic lymphohistiocytosis', 'Immunodeficiency by defective expression of HLA class 2', 'Pyogenic arthritis - pyoderma gangrenosum - acne', 'Familial adenomatous polyposis', 'Thymic aplasia', 'Other metabolic disease', 'Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification', 'Hypohidrotic ectodermal dysplasia with immunodeficiency', 'Leukocyte adhesion deficiency type III', 'hematocrit', 'C-reactive protein measurement', 'glucose measurement', 'hemoglobin measurement', 'bone quantitative ultrasound measurement', 'triglyceride measurement', 'alkaline phosphatase measurement', 'creatine kinase measurement', 'cryptorchidism', 'total cholesterol measurement', 'gestational diabetes', 'low density lipoprotein cholesterol measurement', 'lymphocyte count', 'acute lung injury', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'cystatin C measurement', 'factor VII measurement', 'IGF-1 measurement', 'factor VIII measurement', 'white matter integrity', 'hip geometry', 'factor XI measurement', 'intraocular pressure measurement', 'sex hormone-binding globulin measurement', 'age at menarche', 'pelvic organ prolapse', 'FEV/FVC ratio', 'prion disease', 'aspartate aminotransferase measurement', 'protein measurement', 'neutrophil count', 'eosinophil count', 'lymph node metastatic carcinoma', 'appendicular lean mass', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'autoimmune disease', 'congenital heart disease', 'central corneal thickness', 'cholangiocarcinoma', 'reading', 'anxiety', 'primitive neuroectodermal tumor', 'aortic valve calcification', 'non-small cell lung adenocarcinoma', 'axial length measurement', 'contact dermatitis', 'vein disorder', 'in situ carcinoma', 'inborn disorder of amino acid metabolism', 'allergic asthma', 'fatty liver disease', 'alopecia', 'hypoplastic left heart syndrome', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'upper respiratory tract disorder', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'Parkinson disease', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'allergic disease', 'multiple sclerosis', 'skin basal cell carcinoma', 'childhood onset asthma', 'colorectal cancer', 'Lynch syndrome', 'Wilms tumor', 'prune belly syndrome', 'Adams-Oliver syndrome', 'Acropectorovertebral dysplasia', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency', 'Tietz syndrome', 'autosomal dominant Alport syndrome', 'Townes-Brocks syndrome', 'atelosteogenesis type III', 'Osebold-Remondini syndrome', 'brachydactyly type C', 'autosomal dominant brachyolmia', 'Gordon syndrome', 'breast cancer', 'chondrocalcinosis 2', 'congenital contractural arachnodactyly', 'fleck corneal dystrophy', 'Duane retraction syndrome', 'Leri-Weill dyschondrosteosis', 'Beckwith-Wiedemann syndrome', 'esophageal cancer', 'autoinflammatory syndrome, familial, X-linked, Behcet-like 2', 'immunodeficiency 98 with autoinflammation, X-linked', 'metastatic malignant neoplasm', 'granulomatous disease, chronic, autosomal recessive, 5', 'hyper-IgE recurrent infection syndrome 5, autosomal recessive', 'immunodeficiency 81', 'immunodeficiency 82 with systemic inflammation', 'inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive', 'immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias', 'immunodeficiency 75', 'immunodeficiency 76', 'nephrotic syndrome 16', 'immunodeficiency 69', 'immunodeficiency 78 with autoimmunity and developmental delay', 'immunodeficiency 70', 'immunodeficiency 72 with autoinflammation', 'immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia', 'autoinflammation, immune dysregulation, and eosinophilia', 'severe combined immunodeficiency due to CD70 deficiency', 'myofibroblastoma', 'invasive carcinoma', 'adenoviridae infectious disease', 'brain injury', 'nosocomial infection', 'enteritis', 'ulcer disease', 'radiation pneumonitis', 'familial adenomatous polyposis 4', 'severe combined immunodeficiency due to LAT deficiency', 'desmoplastic melanoma', 'myelofibrosis', 'salivary duct carcinoma', 'oral cavity carcinoma', 'rectal carcinoma', 'vertebral disorder', 'digestive system melanoma', 'short-rib thoracic dysplasia 17 with or without polydactyly', 'platelet abnormalities with eosinophilia and immune-mediated inflammatory disease', 'COVID-19', 'liver failure', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'spondyloepimetaphyseal dysplasia', 'gastrointestinal defects and immunodeficiency syndrome 1', 'immunodeficiency 105', 'autoinflammatory disease, X-linked', 'autoinflammatory syndrome with immunodeficiency', 'achalasia-alacrima syndrome', 'choroidal neovascularization', 'rhizomelic dysplasia, Ain-Naz type', 'autoinflammatory disease, multisystem, with immune dysregulation, X-linked', 'hyper-IgE syndrome 6, autosomal dominant, with recurrent infections', 'immunodeficiency 113 with autoimmunity and autoinflammation', 'immunodeficiency 117', 'neutropenia, severe congenital, 11, autosomal dominant', 'autoinflammation with episodic fever and immune dysregulation', 'immunodeficiency 119', 'postmenopausal osteoporosis', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'ankylosing spondylitis', 'deep vein thrombosis', 'angina pectoris', 'atherosclerosis', 'necrotizing enterocolitis', 'gastroesophageal reflux disease', 'seasonal allergic rhinitis', 'breast neoplasm', 'left ventricular hypertrophy', 'stomach neoplasm', 'obstructive sleep apnea', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'neuropathy', 'open-angle glaucoma', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Vitiligo', 'hypospadias', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'exfoliation syndrome', 'focal segmental glomerulosclerosis', 'chronic hepatitis B virus infection', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'meningococcal infection', 'membranous glomerulonephritis', 'nephrotic syndrome', 'osteonecrosis', 'bone disease', 'vascular disease', 'peripheral arterial disease', 'sclerosing cholangitis', 'scoliosis', 'brain infarction', 'thoracic aortic aneurysm', 'ventricular fibrillation', 'colonic neoplasm', 'erythrocyte count', 'platelet count', 'vital capacity', 'forced expiratory volume', 'smoking behavior', 'body weight', 'body mass index', 'body fat distribution', 'waist-hip ratio', 'corneal topography', 'neuroimaging measurement', 'metastatic neoplasm', 'wheezing', 'enthesitis-related juvenile idiopathic arthritis', 'Chronic Obstructive Asthma', 'carotid atherosclerosis', 'pulse wave reflection index measurement', 'total hip arthroplasty', 'kidney injury', 'muscle atrophy', 'chromosomal aberration frequency', 'bone metastasis', 'HMG CoA reductase inhibitor use measurement', 'Inhalant adrenergic use measurement', 'Glucocorticoid use measurement', 'low density lipoprotein triglyceride measurement', 'diverticular disease', 'corneal resistance factor', 'citrate measurement', 'cholesteryl ester measurement', 'glucuronate measurement', 'isocitrate measurement', 'atopic asthma', 'coinfection', 'total joint arthroplasty', 'aspartate aminotransferase to alanine aminotransferase ratio', 'nephrotoxicity', 'inflammatory bowel disease, immunodeficiency, and encephalopathy', 'severe malarial anemia', 'total knee arthroplasty', 'palmitate 16:0 measurement', 'sexual dimorphism measurement', 'body surface area', 'serum lipopolysaccharide activity', 'Birt-Hogg-Dube syndrome', '25-hydroxyvitamin D3 measurement', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'granulosa cell tumor', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'pulmonary tuberculosis', 'tongue squamous cell carcinoma', 'nasopharyngeal squamous cell carcinoma', 'Acute Leukemia', 'Ampulla of Vater Carcinoma', 'Appendix Adenocarcinoma', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Cavernous Hemangioma', 'Central Nervous System Lymphoma', 'Cervical Adenosquamous Carcinoma', 'cervical squamous cell carcinoma', 'Colon Dysplasia', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Endometrial Undifferentiated Carcinoma', 'Fibroblastic Neoplasm', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'nonpapillary renal cell carcinoma', 'Pallister-Hall syndrome', 'periodic fever, immunodeficiency, and thrombocytopenia syndrome', 'platyspondylic dysplasia, Torrance type', 'systemic lupus erythematosus', 'Marfan syndrome', 'melorheostosis', 'mesomelic dysplasia, Kantaputra type', 'metatropic dysplasia', 'Mobius syndrome', 'Muir-Torre syndrome', 'Cowden syndrome 1', 'myotonic dystrophy type 1', 'nail-patella syndrome', 'autosomal dominant progressive nephropathy with hypertension', 'ovarian cancer', 'Peyronie disease', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'Hutchinson-Gilford progeria syndrome', 'familial juvenile hyperuricemic nephropathy type 1', 'Peutz-Jeghers syndrome', 'prostate cancer', 'pseudoachondroplasia', 'autosomal dominant distal renal tubular acidosis', 'retinoblastoma', 'Smith-Magenis syndrome', 'spondyloepiphyseal dysplasia tarda, autosomal dominant', 'spondyloepimetaphyseal dysplasia, Strudwick type', 'spondylometaphyseal dysplasia, Kozlowski type', 'spondylometaphyseal dysplasia, Schmidt type', 'proximal symphalangism', 'syndactyly type 5', 'brachydactyly-elbow wrist dysplasia syndrome', 'tarsal-carpal coalition syndrome', 'thoracolaryngopelvic dysplasia', 'tooth and nail syndrome', 'volvulus of midgut', 'short-limb skeletal dysplasia with severe combined immunodeficiency', 'acrocallosal syndrome', 'acrodermatitis enteropathica', 'acromesomelic dysplasia 2C, Hunter-Thompson type', 'agnathia-otocephaly complex', 'autosomal recessive Alport syndrome', 'amelogenesis imperfecta type 1G', 'microphthalmia with limb anomalies', 'progressive pseudorheumatoid arthropathy of childhood', 'Bloom syndrome', 'kyphomelic dysplasia', 'lung cancer', 'heart defects-limb shortening syndrome', 'chordoma', 'Juberg-Hayward syndrome', 'Costello syndrome', 'cystic fibrosis', 'hereditary renal hypouricemia', 'diastrophic dysplasia', 'Dyggve-Melchior-Clausen disease', 'Ehlers-Danlos syndrome, dermatosparaxis type', 'multiple epiphyseal dysplasia type 4', 'classic Hodgkin lymphoma', 'immunodeficiency, common variable, 2', 'ichthyosis-intellectual disability-dwarfism-renal impairment syndrome', 'Nezelof syndrome', 'spondylometaphyseal dysplasia, Sedaghatian type', 'metaphyseal dysostosis-intellectual disability-conductive deafness syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'carnitine palmitoyl transferase II deficiency, myopathic form', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'nail-patella-like renal disease', 'nephronophthisis 1', 'congenital nephrotic syndrome, Finnish type', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'human papilloma virus infection', 'fibrosarcoma', 'benign neoplasm', 'hypertrophy', 'anaplastic astrocytoma', 'cardiac hypertrophy', 'medical procedure', 'AIDS dementia', 'juvenile idiopathic arthritis', 'insulin resistance', 'prostate intraepithelial neoplasia', 'septic peritonitis', 'vulvar intraepithelial neoplasia', 'renal carcinoma', 'thyroid carcinoma', 'metastatic melanoma', 'pancreatic carcinoma', 'rotavirus infection', 'Cutaneous T-cell lymphoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'muscular disease', 'transitional cell carcinoma of kidney', 'anaplastic large cell lymphoma', 'bacteriemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'peripheral neuropathy', 'testicular seminoma', 'pneumonia', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'refractory anemia with ringed sideroblasts', 'laryngeal neoplasm', 'lung disease', 'brain neoplasm', 'calcification', 'retinopathy', 'thyroid neoplasm'], tissue_specific_expression={'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\"small intestine Peyer's patch\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}, is_essential=False, genetic_constraint={'syn': -0.12650999426841736, 'mis': 4.360300064086914, 'lof': 0.9999799728393555}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.', '*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'breast\\\\': 0, \\\\'atrium auricular region\\\\': 1, \\\\'liver\\\\': 0, \\\\'skeletal muscle tissue\\\\': 1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\\'esophagus mucosa\\\\': 1, \\\\'macrophage\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'segmented neutrophil of bone marrow\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': -1, \\\\'class switched memory B cell\\\\': 0, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 3, \\\\'Brodmann (1909) area 9\\\\': 0, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 1, \\\\'zone of skin\\\\': 1, \\\\'leukocyte\\\\': 0, \\\\'nasopharynx\\\\': -1, \\\\'tonsil\\\\': 0, \\\\'frontal lobe\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'putamen\\\\': 0, \\\\'hematopoietic stem cell\\\\': -1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'testis\\\\': -1, \\\\'bronchus\\\\': -1, \\\\'sigmoid colon\\\\': 0, \\\\'fallopian tube\\\\': 0, \\\\'plasma cell\\\\': -1, \\\\'aorta\\\\': 0, \\\\'adrenal gland\\\\': -1, \\\\'kidney\\\\': 0, \\\\'endometrium\\\\': 0, \\\\'smooth muscle tissue\\\\': 0, \\\\'tibial artery\\\\': 0, \\\\'prefrontal cortex\\\\': 0, \\\\'CD8-positive, alpha-beta T cell\\\\': -1, \\\\'vermiform appendix\\\\': 0, \\\\'lymph node\\\\': 0, \\\\'duodenum\\\\': 0, \\\\'mature eosinophil\\\\': 0, \\\\'prostate gland\\\\': 1, \\\\'C1 segment of cervical spinal cord\\\\': -1, \\\\'lung\\\\': 0, \\\\'inflammatory macrophage\\\\': -1, \\\\'rectum\\\\': 0, \\\\'suprapubic skin\\\\': 0, \\\\'brain\\\\': -1, \\\\'coronary artery\\\\': 0, \\\\'parathyroid gland\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': 0, \\\\'esophagus muscularis mucosa\\\\': 0, \\\\'esophagus\\\\': 1, \\\\'transformed skin fibroblast\\\\': 1, \\\\'heart muscle\\\\': -1, \\\\'pancreas\\\\': 0, \\\\'uterus\\\\': 0, \\\\'placenta\\\\': 0, \\\\'seminal vesicle\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'endothelial cell of umbilical vein (resting)\\\\': 0, \\\\'minor salivary gland\\\\': 0, \\\\'endocervix\\\\': 1, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'CD8-positive, alpha-beta thymocyte\\\\': -1, \\\\'granulocyte monocyte progenitor cell\\\\': -1, \\\\'caudate nucleus\\\\': 0, \\\\'amygdala\\\\': 0, \\\\'temporal lobe\\\\': 0, \\\\'substantia nigra\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'common lymphoid progenitor\\\\': 0, \\\\'cerebral cortex\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 0, \\\\'blood\\\\': -1, \\\\'nucleus accumbens\\\\': 0, \\\\'stomach\\\\': 0, \\\\'oral mucosa\\\\': -1, \\\\'mature neutrophil\\\\': 0, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'bone marrow\\\\': -1, \\\\'gall bladder\\\\': 1, \\\\'colon\\\\': 0, \\\\'cytotoxic CD56-dim natural killer cell\\\\': -1, \\\\'pituitary gland\\\\': 0, \\\\'transverse colon\\\\': 0, \\\\'heart left ventricle\\\\': 0, \\\\'erythroblast\\\\': -1, \\\\'vagina\\\\': 1, \\\\'ovary\\\\': 1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': 1, \\\\'cerebellum\\\\': -1, \\\\'hypothalamus\\\\': -1, \\\\'common myeloid progenitor\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': -1, \\\\'alternatively activated macrophage\\\\': -1, \\\\'thyroid gland\\\\': 1, \\\\'lower leg skin\\\\': 0, \\\\'epididymis\\\\': -1, \\\\'spleen\\\\': 0, \\\\'esophagogastric junction\\\\': 0, \\\\'greater omentum\\\\': 1, \\\\'memory B cell\\\\': 0, \\\\'hippocampus proper\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': -1, \\\\'small intestine\\\\': 1, \\\\'conventional dendritic cell\\\\': -1, \\\\'cortex of kidney\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": 0, \\\\'heart\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': -1, \\\\'caudate-putamen\\\\': -1, \\\\'urinary bladder\\\\': 1, \\\\'ectocervix\\\\': 1, \\\\'regulatory T cell\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 1, \\\\'saliva-secreting gland\\\\': 0, \\\\'neutrophilic metamyelocyte\\\\': -1, \\\\'tibial nerve\\\\': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets'])}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 2, 'used_tools': ['BioGRID', 'MSigDB', 'chembl', 'drug_central', 'extract_entities', 'prot', 'uniprot_base'], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID', 'OpenTargets', 'reactome', 'humanbase_functions', 'Summarize_GO'], 'ui': {}, 'prot_html': '\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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    \\\\n\\\\n\\\\n', 'drug_central_html': '', 'aa_seq_html': '', 'text_notes': []}\\n[TOOL RUN] → reactome\\n{'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id='Q15796', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma'], diseases=['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['SMAD3', 'SMAD4', 'SMURF2'], 'Affinity Capture-MS': ['ARID1A', 'ARID1B', 'ASH2L', 'ATAD3B', 'BCL7A', 'BTBD9', 'BUB3', 'C1ORF116', 'CAD', 'CCT6A', 'CDC27', 'CGA', 'CPSF7', 'CREBBP', 'CSNK1D', 'CTNNB1', 'CUL4A', 'CUL4B', 'DCAF7', 'DDX3Y', 'DGKA', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'EPB41L5', 'ERBB2IP', 'EZH2', 'FAM83G', 'FLOT1', 'FLOT2', 'FYN', 'GSK3A', 'GTF3C2', 'GTF3C6', 'HCFC1', 'HDAC2', 'HDAC4', 'HINT3', 'HSPA4', 'ITGB4', 'KLF5', 'KMT2C', 'LDLRAD4', 'LEMD3', 'MED15', 'MED16', 'MED17', 'MED19', 'MED20', 'MED22', 'MED25', 'MED31', 'MED4', 'MED9', 'MEN1', 'MTMR4', 'NCOA3', 'OGT', 'OPA1', 'OTUB1', 'PARK2', 'PCBP1', 'PCID2', 'PLEKHA4', 'PSPC1', 'RIN1', 'SGSH', 'SIK3', 'SKI', 'SKIL', 'SLC25A3', 'SLC25A5', 'SLC25A6', 'SMAD1', 'SMAD3', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMARCD2', 'SMPDL3B', 'SMURF2', 'SNW1', 'SNX27', 'SQRDL', 'TAF1', 'TAF2', 'TAF3', 'TAF5', 'TAF6', 'TMED8', 'TMOD1', 'TRIM28', 'TRIM33', 'TRIM67', 'U2AF2', 'WDR82', 'WRNIP1', 'WWP2', 'YAF2', 'YY1', 'ZFYVE9'], 'Affinity Capture-RNA': ['DDX58', 'ELAVL1'], 'Affinity Capture-Western': ['ACVR1B', 'ACVR2B', 'AKT1', 'ANAPC10', 'ATF3', 'BRCA2', 'CDC16', 'CDC27', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DAB2', 'DOCK9', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'ETV4', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'FOXP1', 'GLI1', 'GTF2I', 'GTF2IRD1', 'HDAC1', 'HGS', 'HYAL2', 'ING2', 'INSR', 'IRF3', 'IRF7', 'ITCH', 'JUN', 'KAT2A', 'KAT2B', 'KDM6B', 'KLF5', 'LEF1', 'MAPT', 'MED15', 'MED24', 'MED6', 'MEF2A', 'METTL14', 'METTL3', 'MYC', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFYC', 'NOTCH4', 'NUP214', 'OTUB1', 'OVOL2', 'PIAS3', 'PIAS4', 'PIN1', 'PML', 'PRDM16', 'RBBP5', 'RELB', 'RGCC', 'RNF111', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD6', 'SMAD7', 'SMARCA4', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'STRAP', 'TCF12', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TP53', 'TRIM28', 'TRIM33', 'TSC2', 'UCHL1', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWP1', 'WWP2', 'YAP1', 'ZEB1', 'ZFYVE9'], 'Biochemical Activity': ['ACVR1B', 'CAMK2G', 'CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'ITCH', 'TGFBR1'], 'Co-crystal Structure': ['SMAD4'], 'Co-fractionation': ['AP1M1', 'ARID1B', 'CAV1', 'CREBBP', 'CTNNB1', 'HDAC1', 'HMGA2', 'MTA2', 'NAA15', 'NCOA3', 'PARP1', 'PML', 'PRKDC', 'RBM14', 'RELA', 'SMAD3', 'SMAD4', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SUB1', 'TGFBR1', 'TRIM33', 'XRCC6', 'ZFYVE9'], 'Co-localization': ['CAMK2A', 'TGFBR1', 'TP53'], 'FRET': ['BECN1', 'LATS2', 'MYC', 'SMAD1'], 'Phenotypic Enhancement': ['SMAD3', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['SPPL3'], 'Proximity Label-MS': ['CCNF', 'EPHA2', 'OPTN', 'RAB7A', 'SNCA', 'TGOLN2'], 'Reconstituted Complex': ['ANAPC10', 'ANP32B', 'ANP32E', 'ATP5I', 'BPTF', 'CREBBP', 'DAB2', 'DVL1', 'ELAC2', 'ERBB2IP', 'ESR1', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'HDAC2', 'HIPK2', 'HYAL2', 'INSR', 'IRF7', 'JUN', 'KAT2B', 'LCK', 'LEF1', 'MECOM', 'MEF2A', 'MEF2C', 'MYC', 'MYOCD', 'NEDD4L', 'NEFM', 'NFIA', 'NUP214', 'OTUB1', 'PARD3', 'PIAS3', 'PIK3CA', 'PIN1', 'PTMS', 'RHOA', 'SH2D2A', 'SKI', 'SMAD4', 'SMAD7', 'SMURF2', 'SNW1', 'SOD1', 'SP1', 'STUB1', 'SYT1', 'TP53', 'TUBA1B', 'UCHL5', 'YY1', 'ZFYVE9'], 'Two-hybrid': ['ABTB1', 'AKT1', 'ANAPC2', 'ANK3', 'ANTXR2', 'BAZ1A', 'BTBD2', 'C22ORF46', 'C9ORF156', 'CISH', 'COPS5', 'CORO2A', 'CREBBP', 'CSH1', 'CSH2', 'CUL5', 'CYLC2', 'CYP11A1', 'DCUN1D1', 'DNAJB5', 'DNAJC7', 'DOCK8', 'DYNC1H1', 'DYRK1A', 'EEF1A1', 'EIF3L', 'EP300', 'ETV4', 'FAM161B', 'FBP2', 'FOXH1', 'GATAD2B', 'GFER', 'HSD17B3', 'INSR', 'KHDRBS1', 'KIAA1033', 'KPNB1', 'LAMA5', 'LEMD3', 'MAP2K1', 'MLLT4', 'MYC', 'NAGK', 'NCOA6', 'NEDD4L', 'OS9', 'PAPOLA', 'PAPPA', 'PAXIP1', 'PEX19', 'PIAS4', 'PLIN3', 'POU2AF1', 'PPP2R1A', 'PRKAR1A', 'PSAP', 'PSG9', 'PSMD11', 'PSMD8', 'RANBP6', 'RANBP9', 'RARB', 'RASA1', 'RNF123', 'RNPC3', 'ROCK1', 'RPS14', 'RPS27A', 'RXRA', 'SKI', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD9', 'SMURF1', 'SMURF2', 'SNAPIN', 'SNIP1', 'SNRNP70', 'SNW1', 'SP1', 'SRI', 'ST13', 'ST5', 'TBC1D1', 'TGIF1', 'TGM2', 'TRIM62', 'UBA52', 'UBR5', 'XPA', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF41', 'ZNF510', 'ZNHIT6']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF1', 'ARHGEF6', 'ARHGEF7', 'ARL4D', 'CDC40', 'FBXO3', 'IRAK2', 'LHX9', 'LMO2', 'MAP2K3', 'NUAK2', 'PPP2R2D', 'RAB34', 'RAB38', 'RASD2', 'RGS3', 'RHEBL1', 'RHOBTB1', 'RHOD', 'RHOJ', 'RPS27A', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'UHMK1', 'WWP2'], 'Affinity Capture-MS': ['ALDH4A1', 'BACH1', 'E6', 'FANCD2', 'NSP16AB', 'OTUB1', 'PAXIP1', 'RUNX1'], 'Affinity Capture-Western': ['COL1A1', 'COL3A1', 'COL5A1', 'DOK1', 'E6', 'E7', 'GATA4', 'HCVGP1', 'KAP-ALPHA3', 'KLF4', 'LEF1', 'MED', 'MED15', 'MEF2A', 'RNF111', 'SKI', 'SMAD2', 'SMAD4', 'SMOX', 'SNOO', 'UBX', 'VIS', 'WWTR1', 'YAP1'], 'Co-localization': ['E7', 'EZH2-A', 'KLF4'], 'PCA': ['E6', 'SMOX'], 'Phenotypic Enhancement': ['BABO', 'INR', 'SMOX', 'YKI'], 'Phenotypic Suppression': ['BABO', 'HPO', 'INR', 'MYO', 'PLUM', 'PTEN', 'SCGDELTA', 'SMOX'], 'Reconstituted Complex': ['E7', 'LEMD3', 'SMAD2', 'SOX9', 'UBX', 'ZFP128'], 'Two-hybrid': ['CG18095', 'D', 'E6', 'EG', 'FOXH1', 'HOXA13', 'HOXD13', 'HR78', 'SMAD2', 'SMOX', 'UBX', 'ZEB2', 'ZEN']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Overgrowth', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Myocardial fibrosis', 'Increased total eosinophil count', 'Thrombocytosis', 'Anemia', 'Acute kidney injury', 'Glucose intolerance', 'Pulmonary hypoplasia', 'Pneumonia', 'Asthma', 'Ischemic stroke', 'Cerebral ischemia', 'Vascular dilatation', 'Aortic dissection', 'Systemic lupus erythematosus', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Skeletal muscle atrophy', 'Muscular dystrophy', 'Cachexia', 'Thrombophlebitis', 'Miscarriage', 'Ureteral obstruction', 'Airway obstruction', 'Amyotrophic lateral sclerosis', 'Peripheral demyelination', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Reduced sperm motility', 'Urethral stricture', 'Renal atrophy', 'Cervical polyp', 'Shock', 'Granuloma', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Sepsis', 'geleophysic dysplasia', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'hydronephrosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'renal cell adenocarcinoma', 'Autoimmune Hepatitis', 'neurodegenerative disease', 'brain disease', 'aortic disease', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'head and neck neoplasia', 'breast ductal adenocarcinoma', 'laryngeal squamous cell carcinoma', 'ovarian adenocarcinoma', 'ovarian mucinous adenocarcinoma', 'ovarian teratoma', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'dysplastic oral keratinocyte', 'undifferentiated carcinoma', 'cerebral amyloid angiopathy', 'head and neck malignant neoplasia', 'breastfeeding duration', 'urgency urinary incontinence', 'fibrosis', 'Balkan nephropathy', 'congenital rubella', 'echinococcosis', 'Gerstmann syndrome', 'inclusion body myositis', 'muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10', 'severe neurodegenerative syndrome with lipodystrophy', 'Diamond-Blackfan anemia', 'cardiofaciocutaneous syndrome', 'adrenomyeloneuropathy', 'hereditary sensory and autonomic neuropathy', 'nasopharyngeal carcinoma', 'keratoconus', 'dentin dysplasia', 'T-cell non-Hodgkin lymphoma', 'dyskeratosis congenita', 'pneumoconiosis', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'cryopyrin-associated periodic syndrome', 'holoprosencephaly', 'pachyonychia congenita', 'familial rhabdoid tumor', 'familial hyperaldosteronism', 'primary ciliary dyskinesia', 'meningioma', 'pilocytic astrocytoma', 'hemangioblastoma', 'microcephaly-brain defect-spasticity-hypernatremia syndrome', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'heritable pulmonary arterial hypertension', 'juvenile polyposis syndrome', 'congenital herpes simplex virus infection', 'popliteal pterygium syndrome', 'ameloblastoma', 'hypersensitivity pneumonitis', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'emphysema', 'epilepsy', 'esophageal adenocarcinoma', 'fetal growth restriction', 'follicular thyroid adenoma', 'ganglioneuroma', 'follicular thyroid carcinoma', 'gastric adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'genetic disorder', 'germ cell tumor', 'glioblastoma multiforme', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'large cell neuroendocrine carcinoma', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'neural tube defect', 'tuberculosis', 'glioblastoma', 'carcinoma of liver and intrahepatic biliary tract', 'hereditary nonpolyposis colon cancer', 'Zika virus infectious disease', 'left ventricular noncompaction', 'multiminicore myopathy', 'Loeys-Dietz syndrome', 'neurofibromatosis type 1', 'Leber congenital amaurosis', 'osteogenesis imperfecta', 'progressive supranuclear palsy', 'intrahepatic cholestasis', 'lymphedema', 'posterior cortical atrophy', 'follicular lymphoma', 'kidney Wilms tumor', 'bronchopulmonary dysplasia', 'sarcoidosis', 'peeling skin syndrome', 'lissencephaly with cerebellar hypoplasia', 'aggressive NK-cell leukemia', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'familial thoracic aortic aneurysm and aortic dissection', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'precursor B-cell acute lymphoblastic leukemia', 'superficial spreading melanoma', 'lung neoplasm', 'intestinal neoplasm', 'odontogenic neoplasm', 'disorder of ear', 'endometrium neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'carcinoma of pharynx', 'polyp of colon', 'low grade glioma', 'corticobasal degeneration disorder', 'cervical intraepithelial neoplasia', 'viral myocarditis', 'lip and oral cavity carcinoma', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'chondrogenic neoplasm', 'intraepithelial neoplasia', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'pulmonary sarcoidosis', 'gonorrhea', 'B-cell acute lymphoblastic leukemia', 'chronic lymphocytic leukemia', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'myelodysplastic syndrome', 'oral squamous cell carcinoma', 'gastritis', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'acute promyelocytic leukemia', 'adenocarcinoma', 'adenoma', 'age', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', \\\"Barrett's esophagus\\\", 'benign prostatic hyperplasia', 'bladder tumor', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'central nervous system cancer', 'chondrosarcoma', 'chromophobe renal cell carcinoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'clear cell renal carcinoma', 'endometrial carcinoma', 'ovarian serous carcinoma', 'renal fibrosis', 'Abruptio Placentae', 'Adenomyosis', 'Carcinoma, Lewis Lung', 'chronic myelomonocytic leukemia', 'Marchiafava-Bignami Disease', 'oral submucous fibrosis', 'osteoradionecrosis', 'renal nutcracker syndrome', 'amyloidosis', 'mucositis', 'neuroendocrine neoplasm', 'neuromuscular disease', 'oral mucositis', 'Spinal cord injury', 'cutaneous squamous cell carcinoma', 'Barrett adenocarcinoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'pharyngeal squamous cell carcinoma', 'soft tissue sarcoma', 'undifferentiated pleomorphic sarcoma', 'connective tissue disease', 'pneumonitis', 'intrahepatic cholangiocarcinoma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'glomerular disease', 'nephritis', 'Neurogenic bladder', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Uterine leiomyoma', 'Cleft palate', 'Hydrocephalus', 'Cataract', 'Myopia', 'Autism', 'Infertility', 'Diabetes mellitus', 'Insulin resistance', 'Osteoporosis', 'Hyperkeratosis', 'Intellectual disability', 'Ataxia', 'Mental deterioration', 'Stroke', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Hepatic steatosis', 'Obesity', 'mixed connective tissue disease', 'pneumocystosis', 'pseudomyxoma peritonei', 'silicosis', 'toxoplasmosis', 'hemoglobin A1 measurement', 'BMI-adjusted waist-hip ratio', 'liver dysplastic nodule', 'gut microbiome measurement', 'platelet crit', 'allergen exposure measurement', 'calf circumference measurement', 'dysplasia', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'digestive system neoplasm', 'Hepatobiliary Neoplasm', 'American trypanosomiasis', 'acute myocardial infarction', 'pemphigus foliaceus', 'cystic kidney disease', 'Polycystic Kidney Disease', 'arteriosclerosis', 'hyperuricemia', 'skin carcinoma', 'heel bone mineral density', 'pulmonary fibrosis', 'hyperaldosteronism', 'gastric ulcer', 'infarction', 'aortic valve disease', 'heart valve disease', 'mitral valve disease', 'urinary tract obstruction', 'prostate disease', 'stomach disease', 'myocarditis', 'aneurysm', 'enthesopathy', 'musculoskeletal system disease', 'metastasis', 'Gallbladder Adenocarcinoma', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Malignant Mesothelioma', 'Malignant Pancreatic Neoplasm', 'Medullomyoblastoma with Myogenic Differentiation', 'Microcystic Meningioma', 'Mixed Tumor of the Salivary Gland', 'Nasal Cavity Polyp', 'Osteoblastoma', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Paraganglioma', 'Placental Choriocarcinoma', 'Rectal Tubular Adenoma', 'Sarcomatoid Carcinoma', 'Signet Ring Cell Gastric Adenocarcinoma', 'Synovial Chondromatosis', 'Testicular Non-Seminomatous Germ Cell Tumor', 'Testicular Yolk Sac Tumor', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vulvar Squamous Cell Carcinoma', 'acute respiratory distress syndrome', 'sarcopenia', 'rectum cancer', 'acanthosis nigricans', 'mucous membrane pemphigoid', 'punctate palmoplantar keratoderma type III', 'adrenal cortex carcinoma', 'alcoholic liver cirrhosis', 'atrophic gastritis', 'dental fluorosis', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'multiple system atrophy', 'myeloid sarcoma', 'nodular goiter', 'periapical granuloma', 'pulmonary edema', 'renovascular hypertension', 'retinopathy of prematurity', 'rheumatic heart disease', 'thromboangiitis obliterans', 'tooth disease', 'uremia', 'non-alcoholic steatohepatitis', 'Cryptogenic Organizing Pneumonia', 'Fascioliasis', 'Follicular Cyst', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Myocardial Ischemia', 'Pelvic Inflammatory Disease', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Pneumonia, Aspiration', 'Respiratory Syncytial Virus Infection', 'diabetic cardiomyopathy', 'diabetic foot', 'endothelial dysfunction', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'schistosomiasis', 'abortion', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'Bartsocas-Papas syndrome 1', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'SHOX-related short stature', 'intellectual disability, X-linked syndromic, Turner type', 'Fabry disease', 'X-linked corneal dermoid', 'Aarskog-Scott syndrome, X-linked', 'holoprosencephaly-hypokinesia-congenital contractures syndrome', 'Melnick-Needles syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'Wilson disease', 'adenomyosis', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'Ehlers-Danlos syndrome, musculocontractural type', 'tetrasomy 12p', 'sickle cell anemia', 'hypotonia-cystinuria syndrome', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'autoimmune lymphoproliferative syndrome type 2B', 'endometrial cancer', 'Loeys-Dietz syndrome 1', 'hyperinsulinemic hypoglycemia, familial, 4', 'preterm premature rupture of the membranes', 'Mungan syndrome', 'Crouzon syndrome-acanthosis nigricans syndrome', 'papillary renal cell carcinoma', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'pterygium', 'renal cell carcinoma', 'rheumatoid arthritis', 'sarcoma', 'severe acute respiratory syndrome', 'small cell lung carcinoma', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'spondyloarthropathy', 'stroke', 'subarachnoid hemorrhage', 'systemic scleroderma', 'ulcerative colitis', 'melanoma', 'hepatocellular adenoma', 'viral disease', 'HIV infection', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'pneumococcal infection', 'temporal lobe epilepsy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'malaria', 'folate deficiency', 'lung carcinoma', 'ovarian carcinoma', 'familial amyotrophic lateral sclerosis', 'pulmonary arterial hypertension', 'age-related macular degeneration', 'synovial sarcoma', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'villous adenoma', 'mucosal melanoma', 'ovarian clear cell cancer', 'central nervous system primitive neuroectodermal neoplasm', 'Crohn ileitis', 'vertebral column disorder', 'endometrial disorder', 'gastric cancer', 'penile cancer', 'myopia', 'pulmonary alveolar proteinosis', 'Chagas disease', 'leiomyoma', 'brain cancer', 'tuberous sclerosis', 'sick sinus syndrome', 'arteriovenous hemangioma/malformation', 'hypertensive heart disease', 'head and neck carcinoma', 'depressive disorder', 'pneumothorax', 'Richter syndrome', 'peritoneum cancer', 'thyroid cancer', 'disorder of sexual differentiation', 'vulvar melanoma', 'papilloma', 'rectosigmoid junction neoplasm', 'Treacher-Collins syndrome', 'prostatic acinar adenocarcinoma', 'gingival overgrowth', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratoma', 'bone inflammation disease', 'extraosseous osteosarcoma', 'chondroblastic osteosarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'lung benign neoplasm', 'skin cancer', 'cervical cancer', 'seminoma', 'breast angiosarcoma', 'cerebellar pilocytic astrocytoma', 'salivary gland adenoid cystic carcinoma', 'bile duct adenocarcinoma', 'gastroesophageal junction adenocarcinoma', 'thoracic cancer', 'acral lentiginous melanoma', 'endometrial mixed adenocarcinoma', 'female breast carcinoma', 'inflammation', 'erythrocyte volume', 'glomerular filtration rate', 'bone tissue density', 'progesterone amount', 'serum alanine aminotransferase amount', 'serum urea amount', 'serum creatinine amount', 'body height', 'cyst', 'Hypotonia - cystinuria syndrome', 'Chédiak-Higashi syndrome', 'Åland Islands eye disease', 'Hydrocephalus with stenosis of the aqueduct of Sylvius', 'Autoimmune lymphoproliferative syndrome with recurrent viral infections', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Persistent Müllerian duct syndrome', 'WHIM syndrome', 'Familial adenomatous polyposis', 'Other metabolic disease', 'hematocrit', 'C-reactive protein measurement', 'hematological measurement', 'alkaline phosphatase measurement', 'cryptorchidism', 'lymphocyte count', 'gestational diabetes', 'acute lung injury', 'serum gamma-glutamyl transferase measurement', 'HbA1c measurement', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'wet macular degeneration', 'insomnia', 'hypothyroidism', 'pelvic organ prolapse', 'metabolite measurement', 'eosinophil count', 'lymph node metastatic carcinoma', 'embryonal carcinoma', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'monocyte count', 'autoimmune disease', 'congenital heart disease', 'cholangiocarcinoma', 'human african trypanosomiasis', 'reading', 'congenital heart malformation', 'temporomandibular joint disorder', 'axial length measurement', 'myeloid leukemia', 'lupus erythematosus', 'allergic asthma', 'fatty liver disease', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'cataract', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'multiple sclerosis', 'skin basal cell carcinoma', 'brain glioma', 'colorectal cancer', 'Wilms tumor', 'Townes-Brocks syndrome', 'nevoid basal cell carcinoma syndrome', 'breast cancer', 'congenital contractural arachnodactyly', 'Duane retraction syndrome', 'dyschromatosis symmetrica hereditaria', 'metastatic malignant neoplasm', 'Loeys-Dietz syndrome 6', 'cervical squamous intraepithelial neoplasia', 'leukoplakia', 'spinal cord injury', 'ulcer disease', 'desmoplastic melanoma', 'myelofibrosis', 'oral cavity carcinoma', 'rectal carcinoma', 'hydrocephalus, congenital, 3, with brain anomalies', 'nasal cavity and paranasal sinus carcinoma', 'COVID-19', 'Dravet syndrome', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'achalasia-alacrima syndrome', 'metabolic bone disorder', 'congenital heart defects, multiple types, 8, with or without heterotaxy', 'postmenopausal osteoporosis', 'intestinal polyp', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'breast neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'stomach neoplasm', 'ankylosing spondylitis', 'ciliopathy', 'deep vein thrombosis', 'obstructive sleep apnea', 'necrotizing enterocolitis', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'atherosclerosis', 'open-angle glaucoma', 'androgenetic alopecia', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'focal segmental glomerulosclerosis', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'myeloproliferative disorder', 'nephrotic syndrome', 'vascular disease', 'thoracic aortic aneurysm', 'venous thromboembolism', 'platelet count', 'body mass index', 'neuroimaging measurement', 'metastatic neoplasm', 'whole body water mass', 'kidney injury', 'bone metastasis', 'gastrointestinal disease', 'aspartate aminotransferase to alanine aminotransferase ratio', 'urea measurement', 'viral load', '2-hydroxyacetaminophen sulfate measurement', 'aging', 'serum lipopolysaccharide activity', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'ependymoma', 'granulosa cell tumor', 'metaplastic breast carcinoma', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'ACTH-Producing Pituitary Gland Adenoma', 'Adenomatoid Odontogenic Tumor', 'Ampulla of Vater Carcinoma', 'Anal Squamous Cell Carcinoma', 'Anaplastic (Malignant) Meningioma', 'Appendix Adenocarcinoma', 'Appendix Goblet Cell Carcinoid', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Breast Carcinoma by Gene Expression Profile', 'cervical squamous cell carcinoma', 'Columnar Cell Hyperplasia of the Breast', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Extramammary Paget Disease', 'fibrodysplasia ossificans progressiva', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'Pallister-Hall syndrome', 'Nager acrofacial dysostosis', 'Marfan syndrome', 'Cowden syndrome 1', 'nail-patella syndrome', 'ovarian cancer', 'Andersen-Tawil syndrome', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'nonpapillary renal cell carcinoma', 'Mobius syndrome', 'Peyronie disease', 'prostate cancer', 'retinoblastoma', 'acrodermatitis enteropathica', 'mitochondrial DNA depletion syndrome 4a', 'Alstrom syndrome', 'anencephaly 1', 'microphthalmia with limb anomalies', 'Bloom syndrome', 'lung cancer', 'cerebrotendinous xanthomatosis', 'cystic fibrosis', 'recessive dystrophic epidermolysis bullosa', 'Haim-Munk syndrome', 'Laurence-Moon syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'ischemic cardiomyopathy', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'fibrosarcoma', 'hypertrophy', 'actinic keratosis', 'anaplastic astrocytoma', 'anaplastic oligodendroglioma', 'cardiac hypertrophy', 'AIDS dementia', 'pancreatic carcinoma', 'prostate intraepithelial neoplasia', 'thyroid carcinoma', 'insulin resistance', 'esophageal carcinoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'acute megakaryoblastic leukaemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'pleomorphic liposarcoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'Pick disease', 'testicular seminoma', 'osteomyelitis', 'spina bifida', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'lung disease', 'dental caries', 'serous adenocarcinoma', 'retinopathy', 'adrenal gland neoplasm'], tissue_specific_expression={'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\"small intestine Peyer's patch\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}, is_essential=False, genetic_constraint={'syn': 0.11195000261068344, 'mis': 4.47730016708374, 'lof': 1.0}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.', '*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett\\\\'s esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'frontal lobe\\\\': -1, \\\\'endothelial cell of umbilical vein (resting)\\\\': 2, \\\\'zone of skin\\\\': 0, \\\\'regulatory T cell\\\\': 1, \\\\'pancreas\\\\': -1, \\\\'suprapubic skin\\\\': -1, \\\\'temporal lobe\\\\': -1, \\\\'parathyroid gland\\\\': -1, \\\\'spleen\\\\': -1, \\\\'Brodmann (1909) area 9\\\\': -1, \\\\'breast\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': -1, \\\\'alternatively activated macrophage\\\\': 2, \\\\'segmented neutrophil of bone marrow\\\\': 4, \\\\'placenta\\\\': -1, \\\\'mature eosinophil\\\\': 1, \\\\'granulocyte monocyte progenitor cell\\\\': 0, \\\\'gall bladder\\\\': -1, \\\\'esophagus muscularis mucosa\\\\': -1, \\\\'seminal vesicle\\\\': -1, \\\\'endocervix\\\\': -1, \\\\'lower leg skin\\\\': -1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 2, \\\\'CD8-positive, alpha-beta T cell\\\\': 3, \\\\'cerebral cortex\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': 4, \\\\'hippocampus proper\\\\': -1, \\\\'uterus\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': 3, \\\\'tonsil\\\\': -1, \\\\'esophagus\\\\': 0, \\\\'transverse colon\\\\': -1, \\\\'pituitary gland\\\\': -1, \\\\'coronary artery\\\\': -1, \\\\'memory B cell\\\\': 0, \\\\'sigmoid colon\\\\': -1, \\\\'cerebellum\\\\': -1, \\\\'erythroblast\\\\': 2, \\\\'prefrontal cortex\\\\': -1, \\\\'nucleus accumbens\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'vermiform appendix\\\\': -1, \\\\'greater omentum\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': 1, \\\\'leukocyte\\\\': 2, \\\\'adrenal gland\\\\': -1, \\\\'atrium auricular region\\\\': -1, \\\\'thyroid gland\\\\': 0, \\\\'tibial artery\\\\': -1, \\\\'common lymphoid progenitor\\\\': 3, \\\\'urinary bladder\\\\': -1, \\\\'duodenum\\\\': -1, \\\\'heart muscle\\\\': -1, \\\\'small intestine\\\\': -1, \\\\'neutrophilic metamyelocyte\\\\': 3, \\\\'minor salivary gland\\\\': -1, \\\\'rectum\\\\': 0, \\\\'ovary\\\\': -1, \\\\'substantia nigra\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': -1, \\\\'class switched memory B cell\\\\': 1, \\\\'fallopian tube\\\\': -1, \\\\'esophagus mucosa\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 0, \\\\'bronchus\\\\': -1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": -1, \\\\'kidney\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'macrophage\\\\': 1, \\\\'aorta\\\\': -1, \\\\'skeletal muscle tissue\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': 4, \\\\'caudate-putamen\\\\': -1, \\\\'liver\\\\': -1, \\\\'cytotoxic CD56-dim natural killer cell\\\\': 2, \\\\'mature neutrophil\\\\': 2, \\\\'hypothalamus\\\\': -1, \\\\'transformed skin fibroblast\\\\': -1, \\\\'bone marrow\\\\': -1, \\\\'inflammatory macrophage\\\\': 0, \\\\'cortex of kidney\\\\': -1, \\\\'lung\\\\': -1, \\\\'epididymis\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'saliva-secreting gland\\\\': -1, \\\\'nasopharynx\\\\': -1, \\\\'colon\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'stomach\\\\': -1, \\\\'testis\\\\': -1, \\\\'smooth muscle tissue\\\\': 0, \\\\'putamen\\\\': -1, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 5, \\\\'C1 segment of cervical spinal cord\\\\': 0, \\\\'blood\\\\': -1, \\\\'hematopoietic stem cell\\\\': 1, \\\\'caudate nucleus\\\\': -1, \\\\'amygdala\\\\': -1, \\\\'brain\\\\': 0, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'ectocervix\\\\': -1, \\\\'prostate gland\\\\': -1, \\\\'conventional dendritic cell\\\\': 4, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'heart left ventricle\\\\': -1, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 0, \\\\'vagina\\\\': -1, \\\\'esophagogastric junction\\\\': -1, \\\\'lymph node\\\\': -1, \\\\'endometrium\\\\': -1, \\\\'heart\\\\': -1, \\\\'oral mucosa\\\\': -1, \\\\'CD8-positive, alpha-beta thymocyte\\\\': 4, \\\\'common myeloid progenitor\\\\': 0, \\\\'tibial nerve\\\\': -1, \\\\'plasma cell\\\\': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id='P84022', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'], diseases=['Colorectal cancer', 'Loeys-Dietz syndrome 3'], pathways=[], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['BAG3', 'HIF1A', 'SMAD2', 'SMAD4', 'SMURF1', 'SMURF2', 'SP1'], 'Affinity Capture-MS': ['ARID1A', 'ATG14', 'ATG16L1', 'ATXN2L', 'BUB3', 'C1ORF116', 'CD6', 'CDK11A', 'CHD8', 'CIC', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DCAF4', 'DCAF7', 'DDX3X', 'DDX3Y', 'DDX4', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'DZIP3', 'EPB41L5', 'ERBB2IP', 'EVA1B', 'EZH2', 'FAM83G', 'FURIN', 'HINT3', 'HSPA4', 'IRF7', 'IRS1', 'ITGB4', 'KAT6A', 'KCTD16', 'LACRT', 'LDLRAD4', 'LEMD3', 'LRCH1', 'LSR', 'MAP2K3', 'MAPK1', 'MED16', 'MED4', 'NCOA3', 'NF2', 'OPA1', 'OTUB1', 'OTUD1', 'PABPC1', 'PARK2', 'PJA1', 'PLEKHA4', 'PPIE', 'PRNP', 'PSPC1', 'PTPN6', 'RAB11FIP5', 'RPL3', 'RPL4', 'RPSAP15', 'SIK3', 'SLC25A12', 'SLC9A3R2', 'SMAD1', 'SMAD2', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMURF2', 'SNW1', 'SQRDL', 'SUZ12', 'TAF1', 'TAF2', 'TCP1', 'TGFB1', 'TMEM192', 'TRIM33', 'TRIM67', 'TRIP4', 'U2AF2', 'UGT1A10', 'USP33', 'USP7', 'VAV2', 'WWP2', 'YTHDF2', 'YY1', 'ZFP69B', 'ZFYVE9', 'ZRANB1'], 'Affinity Capture-RNA': ['DDX58', 'TRIM25'], 'Affinity Capture-Western': ['ACTB', 'ACVR1B', 'AKT1', 'ANAPC10', 'AR', 'ATF2', 'ATF3', 'BACH1', 'BRCA1', 'BRCA2', 'BTRC', 'CBL', 'CDC16', 'CDC25A', 'CDC27', 'CDKN1A', 'CEBPD', 'CHRD', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CSNK1G2', 'CTCF', 'CTNNB1', 'CUL1', 'DAB2', 'DACH1', 'DEDD', 'DOCK9', 'E2F4', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXL2', 'FOXM1', 'FOXO1', 'FOXO3', 'FOXO4', 'GRIP1', 'GSK3B', 'HDAC4', 'HDAC5', 'HGS', 'HIF1A', 'HNF4A', 'HYAL2', 'ID1', 'IRF7', 'JUN', 'KAT2A', 'KAT2B', 'KAT6A', 'KDM5C', 'KDM6B', 'KLF5', 'KPNB1', 'LEF1', 'MAFK', 'MECOM', 'MED15', 'MED24', 'MED6', 'MEN1', 'METTL14', 'METTL3', 'MKL1', 'MYC', 'MYD88', 'MYOCD', 'NCOA1', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIC', 'NFYC', 'NOTCH1', 'NOTCH4', 'NR3C1', 'NR4A1', 'NUP214', 'OTUB1', 'OTUD1', 'OVOL2', 'PAX6', 'PCK2', 'PDLIM5', 'PIAS3', 'PIAS4', 'PIN1', 'PITX1', 'PITX2', 'PML', 'PPARG', 'PPP1R12C', 'PRDM16', 'PRTN3', 'RARA', 'RBBP5', 'RBL1', 'RBX1', 'RELB', 'RGCC', 'RNF111', 'RNF31', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SETD2', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD7', 'SMARCA4', 'SMARCC2', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'SQSTM1', 'SREBF2', 'SRY', 'STRAP', 'STUB1', 'SUV39H1', 'TCF12', 'TGFB1I1', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TGIF2', 'TOB1', 'TP53', 'TRIB3', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'TSC22D4', 'UCHL1', 'UCHL5', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWOX', 'WWP1', 'WWP2', 'YAP1', 'ZC3H12A', 'ZEB1', 'ZEB2', 'ZFYVE9', 'ZMIZ1'], 'Biochemical Activity': ['CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'CSNK1G2', 'MAPK1', 'NEDD4', 'NEDD4L', 'OTUB1', 'TGFBR1', 'USP15', 'USP7', 'WWP2'], 'Co-crystal Structure': ['SMAD3', 'SMAD4', 'ZFYVE9'], 'Co-fractionation': ['ALKBH2', 'ANAPC10', 'APP', 'ARID1B', 'CDH1', 'CREBBP', 'CTCF', 'CTNNB1', 'CUL1', 'DDR1', 'FOXO3', 'HDAC1', 'HMGA2', 'IGF1R', 'ITGB1', 'JUND', 'MTA2', 'NAA15', 'NT5DC3', 'PARP1', 'PRKDC', 'RBM14', 'RBX1', 'RELA', 'RIPK1', 'RNMT', 'SIN3A', 'SKP1', 'SMAD2', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SP1', 'SUB1', 'TRIM33', 'XRCC5', 'XRCC6', 'ZFHX3', 'ZFYVE9'], 'Co-localization': ['AKT1', 'BMP7', 'CAMK2G', 'CDK2', 'CDK4', 'EPAS1', 'ETS1', 'FOXO3', 'HIF1A', 'IRF7', 'MAP3K7', 'MAPK8', 'MAX', 'TP53', 'TRIM62'], 'Cross-Linking-MS (XL-MS)': ['RPL10A'], 'FRET': ['SMAD4', 'STUB1'], 'PCA': ['SMAD4', 'SMAD7'], 'Phenotypic Enhancement': ['HIF1A', 'SMAD2', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['JAK1'], 'Protein-RNA': ['LINC00941'], 'Protein-peptide': ['CREBBP', 'FOXH1', 'ITCH', 'LEF1', 'NEDD4', 'PIN1'], 'Proximity Label-MS': ['NFIA'], 'Reconstituted Complex': ['ANAPC10', 'APP', 'AR', 'ATF2', 'ATF3', 'BPTF', 'BRCA1', 'BRCA2', 'CEBPA', 'CEBPB', 'CEBPD', 'CITED2', 'CREBBP', 'CTCF', 'DAB2', 'DDX5', 'DEDD', 'DNMT3L', 'DVL1', 'E2F4', 'EID2', 'EIF4B', 'EP300', 'ERBB2IP', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXM1', 'GSK3B', 'HDAC1', 'HDAC4', 'HDAC5', 'HIF1A', 'HIPK2', 'HNF4A', 'HYAL2', 'IRF7', 'ITCH', 'JUN', 'JUNB', 'JUND', 'KAT2B', 'KAT6A', 'KPNB1', 'LCK', 'LEF1', 'LEMD3', 'MAX', 'MDM4', 'MECOM', 'MYC', 'MYOCD', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIA', 'NOTCH1', 'NR3C1', 'NUP153', 'NUP214', 'PARD3', 'PIAS2', 'PIAS3', 'PIAS4', 'PIK3CA', 'PIN1', 'RBL1', 'RUNX2', 'S100A4', 'SH2D2A', 'SIN3A', 'SKI', 'SKIL', 'SMAD3', 'SMAD4', 'SMURF2', 'SNW1', 'SP1', 'STUB1', 'TFE3', 'TGFB1I1', 'TGFBR1', 'TGIF1', 'TP53', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'UCHL5', 'USP15', 'VDR', 'WWOX', 'XPO6', 'YY1', 'ZFYVE9', 'ZMIZ1'], 'Two-hybrid': ['AATF', 'AES', 'ANK3', 'APMAP', 'APOB', 'AR', 'ATF2', 'BLZF1', 'C10ORF54', 'C14ORF105', 'CCDC33', 'CDC25A', 'CFDP1', 'CFH', 'CFLAR', 'CHRD', 'CORO1A', 'CPSF7', 'CPTP', 'CREBBP', 'CRX', 'CSH2', 'CXXC5', 'CYP11A1', 'DEDD', 'DNAJB4', 'DNAJB5', 'EBI3', 'EP300', 'EPAS1', 'FAM90A1', 'FBLN1', 'FLI1', 'FLNA', 'FOS', 'FOXH1', 'GGA1', 'GIT2', 'GMEB1', 'HDAC1', 'HEY1', 'HEYL', 'HIF1A', 'HIVEP1', 'HNRNPK', 'HOXC11', 'HP', 'ISL1', 'JUN', 'JUNB', 'KANSL1', 'KDM2A', 'KMT2B', 'LBP', 'MCM3AP', 'MEOX2', 'MTF2', 'MYC', 'MYD88', 'NCOA6', 'NEDD4', 'NEDD9', 'NR4A1', 'PAPPA', 'PARP4', 'PCDH1', 'PCK2', 'PHC2', 'PIAS4', 'PIN1', 'PLAG1', 'PLAGL1', 'PLG', 'PPP1R12C', 'PPP2R1A', 'PRDM4', 'PROX1', 'PSMB1', 'PSMD11', 'RANBP9', 'RBPMS', 'RBX1', 'RCVRN', 'RELA', 'RIOK2', 'RNF31', 'RPA1', 'RPLP0', 'SAP130', 'SBK3', 'SERTAD1', 'SETD2', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMURF1', 'SMURF2', 'SNRNP70', 'SNW1', 'SP1', 'SQSTM1', 'SS18L1', 'ST6GALNAC2', 'SVEP1', 'TANK', 'TDP2', 'TEKT4', 'TF', 'TGM2', 'TLR4', 'TMED1', 'TSC22D4', 'UBQLN4', 'USP7', 'VDR', 'WWP1', 'WWP2', 'XRCC6', 'ZBTB16', 'ZBTB3', 'ZC3H12A', 'ZCCHC14', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF329', 'ZNF774', 'ZNF83']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF6', 'ARHGEF7', 'CLASRP', 'FBXO3', 'GSC', 'MAP2K3', 'PPP2R2D', 'RAB38', 'RASD2', 'RGS3', 'RRAS2', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'WEE1', 'WWP2'], 'Affinity Capture-MS': ['ATG16L1', 'E6', 'NSP6', 'OTUB1', 'SMAD3'], 'Affinity Capture-Western': ['AXIN1', 'COL1A1', 'COL3A1', 'COL5A1', 'DDX5', 'DOK1', 'E6', 'E7', 'EP300', 'GATA4', 'GNB2L1', 'HCVGP1', 'HDAC4', 'KLF4', 'MED15', 'MELK', 'N', 'RNF111', 'SKI', 'SMAD3', 'SMAD3A', 'SMAD4', 'TGFB1I1', 'TOB1', 'TOB1A', 'TOB1B', 'VDR', 'ZEB1'], 'Co-localization': ['E7', 'N'], 'PCA': ['E6'], 'Phenotypic Enhancement': ['SMAD3A'], 'Phenotypic Suppression': ['SMAD3A'], 'Proximity Label-MS': ['M'], 'Reconstituted Complex': ['E6', 'E7', 'GATA4', 'N', 'SIN3A', 'SMAD3', 'SOX9', 'YAP1', 'ZFP128'], 'Synthetic Growth Defect': ['MMP9'], 'Two-hybrid': ['DVL1', 'E6', 'ERBB2IP', 'FOXH1', 'GATA4', 'HCVGP1', 'JUN', 'MAGI2', 'PARD3', 'SMAD3', 'ZEB2']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Large for gestational age', 'Alopecia', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Right ventricular hypertrophy', 'Myocardial fibrosis', 'Hallux valgus', 'Increased total eosinophil count', 'Acute kidney injury', 'Renal artery stenosis', 'Hypoglycemia', 'Glucose intolerance', 'Abnormal thrombosis', 'Rectal prolapse', 'Esophageal stricture', 'Pulmonary hypoplasia', 'Asthma', 'Cerebral cortical atrophy', 'Ischemic stroke', 'Aortic root aneurysm', 'Aortic dissection', 'Spontaneous pneumothorax', 'Vascular dilatation', 'Cerebral ischemia', 'Immunodeficiency', 'Systemic lupus erythematosus', 'Oral leukoplakia', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Back pain', 'Muscular dystrophy', 'Hernia of the abdominal wall', 'Cachexia', 'Ascending aortic dissection', 'Venous thrombosis', 'Ascending tubular aorta aneurysm', 'Ureteral obstruction', 'Airway obstruction', 'Pituitary prolactin cell adenoma', 'Premature ovarian insufficiency', 'Intervertebral disk degeneration', 'Lipodystrophy', 'Hamartoma', 'Chordoma', 'Stress urinary incontinence', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Urethral stricture', 'Allergy', 'Renal atrophy', 'Pulmonary bulla', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Hernia', 'Sepsis', 'Skin ulcer', 'Left ventricular dilatation', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'adolescent idiopathic scoliosis', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'gamma chain deficiency', 'seborrheic keratosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'smoking initiation', 'Staphylococcus aureus infection', 'rheumatic disease', 'lupus nephritis', 'pulse pressure measurement', 'neurodegenerative disease', 'retinal detachment', 'Autoimmune Hepatitis', 'non-high density lipoprotein cholesterol measurement', 'brain disease', 'aortic disease', 'neonatal abstinence syndrome', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'non-Hodgkins lymphoma', 'breast ductal adenocarcinoma', 'systolic blood pressure', 'diastolic blood pressure', 'pulmonary artery enlargement', 'laryngeal squamous cell carcinoma', 'cystadenocarcinoma', 'ovarian mucinous adenocarcinoma', 'smoking status measurement', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'cerebral amyloid angiopathy', 'autoimmune thyroid disease', 'stricture', 'head and neck malignant neoplasia', 'urgency urinary incontinence', 'fibrosis', 'diastolic blood pressure change measurement', 'drug use measurement', 'allergic conjunctivitis', 'aortic valve insufficiency', 'Balkan nephropathy', 'bronchiolitis obliterans', 'congenital rubella', 'coronavirus infectious disease', 'echinococcosis', 'endodermal sinus tumor', 'Gerstmann syndrome', 'Guillain-Barre syndrome', 'influenza', 'intestinal cancer', 'legionellosis', 'lymphatic system disease', 'male reproductive organ cancer', 'aneurysm-osteoarthritis syndrome', 'autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome', 'hyperuricemic nephropathy, familial juvenile type 3', 'graft versus host disease', 'autoimmune lymphoproliferative syndrome type 4', 'combined immunodeficiency due to LRBA deficiency', 'adenine phosphoribosyltransferase deficiency', 'karyomegalic interstitial nephritis', 'dyskeratosis congenita, autosomal recessive 5', 'TCR-alpha-beta-positive T-cell deficiency', 'severe combined immunodeficiency due to IKK2 deficiency', 'immunodeficiency 18', 'immunodeficiency 23', 'severe combined immunodeficiency due to CTPS1 deficiency', 'severe neurodegenerative syndrome with lipodystrophy', 'periodic fever-infantile enterocolitis-autoinflammatory syndrome', 'immunodeficiency 37', 'chronic atrial and intestinal dysrhythmia', 'DOCK2 deficiency', 'DDX41-related hematologic malignancy predisposition syndrome', 'fibrochondrogenesis 2', 'C3 glomerulonephritis', 'agammaglobulinemia 7, autosomal recessive', 'autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency', 'infantile-onset periodic fever-panniculitis-dermatosis syndrome', 'lung disease, immunodeficiency, and chromosome breakage syndrome;', 'neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade', 'chronic diarrhea due to glucoamylase deficiency', 'Bardet-Biedl syndrome', 'familial pancreatic carcinoma', 'nasopharyngeal carcinoma', 'craniosynostosis', 'keratoconus', 'common variable immunodeficiency', 'hyperplastic polyposis syndrome', 'dentin dysplasia', 'T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'qualitative or quantitative defects of dysferlin', 'holoprosencephaly', 'attenuated familial adenomatous polyposis', 'isolated agammaglobulinemia', 'pachyonychia congenita', 'familial hyperaldosteronism', 'hypohidrotic ectodermal dysplasia', 'primary ciliary dyskinesia', 'APC-related attenuated familial adenomatous polyposis', 'meningioma', 'multiple epiphyseal dysplasia', 'hemangioblastoma', 'Moyamoya disease', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'IgG4-related disease', 'juvenile polyposis syndrome', 'pituitary tumor', 'ameloblastoma', 'exstrophy-epispadias complex', 'autoimmune lymphoproliferative syndrome', 'syringomyelia', 'selective IgM deficiency', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', 'congestive heart failure', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'embryonal rhabdomyosarcoma', 'emphysema', 'epilepsy', 'fetal growth restriction', 'ganglioneuroma', 'gastric adenocarcinoma', 'esophageal adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'glioblastoma multiforme', 'hypertension', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'tuberculosis', 'glioblastoma', 'chronic granulomatous disease', 'liver mesenchymal hamartoma', 'activated PI3K-delta syndrome', 'carcinoma of liver and intrahepatic biliary tract', 'cutaneous polyarteritis nodosa', 'hereditary nonpolyposis colon cancer', 'Polymerase proofreading-related adenomatous polyposis', 'Zika virus infectious disease', 'regressive spondylometaphyseal dysplasia', 'Jeune syndrome', 'Li-Fraumeni syndrome', 'posterior cortical atrophy', '22q11.2 deletion syndrome', 'Loeys-Dietz syndrome', 'congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization', 'intrahepatic cholestasis', 'bronchopulmonary dysplasia', 'Hirschsprung disease', 'mucinous adenocarcinoma of the appendix', 'Lhermitte-Duclos disease', 'sarcoidosis', 'peeling skin syndrome', 'Fanconi anemia', 'dysspondyloenchondromatosis', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'acute liver failure', 'discoid lupus erythematosus', 'familial thoracic aortic aneurysm and aortic dissection', 'renal hypoplasia', 'renal dysplasia', 'spondyloepiphyseal dysplasia tarda', 'ulnar hemimelia', 'radial hemimelia', 'growth hormone-producing pituitary gland neoplasm', 'encephalitis', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'autosomal dominant cerebellar ataxia', 'precursor B-cell acute lymphoblastic leukemia', 'chronic graft versus host disease', 'superficial spreading melanoma', 'renal pelvis/ureter urothelial carcinoma', 'tubulointerstitial kidney disease, autosomal dominant, 2', 'lung neoplasm', 'intestinal neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'neoplasm of esophagus', 'tumor of parathyroid gland', 'polyp of colon', 'low grade glioma', 'coronary atherosclerosis', 'gram-negative bacterial infections', 'sexually transmitted disease', 'radiculitis', 'viral myocarditis', 'lip and oral cavity carcinoma', 'immunodeficiency 14b, autosomal recessive', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'respiratory tract infectious disorder', 'chondrogenic neoplasm', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'synucleinopathy', 'pulmonary sarcoidosis', 'gonorrhea', 'chronic lymphocytic leukemia', 'neoplasm of mature B-cells', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'metastatic prostate cancer', 'T-cell acute lymphoblastic leukemia', 'unspecified peripheral T-cell lymphoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'oral squamous cell carcinoma', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'adenocarcinoma', 'adenoma', 'adenosquamous lung carcinoma', 'adrenal gland pheochromocytoma', 'alveolar rhabdomyosarcoma', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', 'benign prostatic hyperplasia', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'Burkitts lymphoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'chondrosarcoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'chronic pancreatitis', 'clear cell renal carcinoma', 'endometrial carcinoma', 'renal fibrosis', 'Adenomyosis', 'immunoproliferative small intestinal disease', 'Posterior Leukoencephalopathy Syndrome', 'amyloidosis', 'neuroendocrine neoplasm', 'Spinal cord injury', 'B-cell non-Hodgkins lymphoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'intrahepatic cholangiocarcinoma', 'pharyngeal squamous cell carcinoma', 'connective tissue disease', 'pneumonitis', 'Carcinoma, Lewis Lung', 'soft tissue sarcoma', 'adult onset asthma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'renal hypertension', 'glomerular disease', 'nephritis', 'positive regulation of ovulation', 'Neurogenic bladder', 'Inguinal hernia', 'Abnormality of the urinary system', 'Renal insufficiency', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Nephrocalcinosis', 'Uterine leiomyoma', 'Cleft palate', 'Retrognathia', 'Strabismus', 'Cataract', 'Proptosis', 'Myopia', 'Pectus excavatum', 'Infertility', 'Hematuria', 'Diabetes mellitus', 'Hyperinsulinemia', 'Insulin resistance', 'Abnormality of the skeletal system', 'Osteopenia', 'Osteoporosis', 'Jaundice', 'Eczematoid dermatitis', 'Global developmental delay', 'Stroke', 'Encephalopathy', 'Parkinsonism', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Cholestasis', 'Hepatic steatosis', 'Obesity', 'ornithine carbamoyltransferase deficiency', 'pseudomyxoma peritonei', 'silicosis', 'spinal stenosis', 'BMI-adjusted waist-hip ratio', 'BMI-adjusted waist circumference', 'body fat percentage', 'balding measurement', 'liver dysplastic nodule', 'wellbeing measurement', 'insomnia measurement', 'eosinophil percentage of leukocytes', 'eosinophil percentage of granulocytes', 'BMI-adjusted hip circumference', 'calf circumference measurement', 'chronic hepatitis', 'dysplasia', 'interstitial cystitis', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'oral lichen planus', 'rhinitis', 'small cell carcinoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'Hepatobiliary Neoplasm', 'acute myocardial infarction', 'peritonitis', 'pemphigus foliaceus', 'paraneoplastic pemphigus', 'cystic kidney disease', 'ovarian dysfunction', 'Arteritis', 'Polyarteritis Nodosa', 'arteriosclerosis', 'idiopathic dilated cardiomyopathy', 'hyperuricemia', 'female reproductive endometrioid cancer', 'skin carcinoma', 'heel bone mineral density', 'marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections', 'central nervous system disease', 'sum of eosinophil and basophil counts', 'lower respiratory tract disease', 'pulmonary fibrosis', 'infarction', 'corneal disease', 'vertebral joint disease', 'aortic valve disease', 'cervical disc degenerative disorder', 'hemorrhoid', 'mitral valve disease', 'feeling nervous measurement', 'stomach disease', 'myocarditis', 'aneurysm', 'laryngeal disease', 'musculoskeletal system disease', 'Gallbladder Adenocarcinoma', 'Gallbladder Adenoma', 'Gastric Neuroendocrine Tumor G1', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Mast Cell Sarcoma', 'Nasal Cavity Polyp', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Ovarian Granulosa Cell Tumor', 'Peritoneal Multicystic Mesothelioma', 'Pituitary Gland Adenoma', 'Placental Choriocarcinoma', 'Pleural Epithelioid Mesothelioma', 'Poorly Differentiated Thyroid Gland Carcinoma', 'Rectal Tubular Adenoma', 'Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions', 'Signet Ring Cell Gastric Adenocarcinoma', 'small intestinal adenocarcinoma', 'Spinal Chordoma', 'Testicular Embryonal Carcinoma', 'Thyroid Gland Oncocytic Follicular Carcinoma', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vaginal Melanoma', 'hamartoma', 'acute respiratory distress syndrome', 'rectum cancer', 'acanthosis nigricans', 'cholesteatoma', 'Primary Pulmonary Diffuse Large B-Cell Lymphoma', 'developmental dysplasia of the hip', 'sarcopenia', 'mucous membrane pemphigoid', 'osteoarthritis, hip', 'osteoarthritis, spine', 'adrenal cortex carcinoma', 'adrenal gland hyperfunction', 'alcoholic cardiomyopathy', 'aortitis', 'atrial heart septal defect', 'causalgia', 'coronary aneurysm', 'diastolic heart failure', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'joint disease', 'lipoid nephrosis', 'mouth disease', 'multiple system atrophy', 'myeloid sarcoma', 'ocular hypertension', 'parathyroid adenoma', 'proliferative vitreoretinopathy', 'pulmonary edema', 'pulpitis', 'Raynaud disease', 'renovascular hypertension', 'rheumatic heart disease', 'Schnitzler syndrome', 'thromboangiitis obliterans', 'ulcerative proctosigmoiditis', 'uremia', 'non-alcoholic steatohepatitis', 'rotator cuff tear', 'Anemia, Hemolytic, Autoimmune', 'Cardiac Tamponade', 'End Stage Liver Disease', 'Endometritis', 'Escherichia coli Infections', 'Genital neoplasm, female', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Lentivirus Infections', 'Myocardial Ischemia', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Tularemia', 'diabetic cardiomyopathy', 'endothelial dysfunction', 'gliosarcoma', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'metastatic colorectal cancer', 'enterocolitis', 'primary biliary cirrhosis', 'abortion', 'psoriasis vulgaris', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'primary hyperoxaluria type 2', 'hyperimmunoglobulinemia D with periodic fever', 'autosomal recessive polycystic kidney disease', 'Senior-Loken syndrome 1', 'reticular dysgenesis', 'schneckenbecken dysplasia', 'combined immunodeficiency due to ZAP70 deficiency', 'familial isolated congenital asplenia', 'brachyolmia type 1, Hobaek type', 'brachyolmia type 1, toledo type', 'spondyloperipheral dysplasia', 'thoracomelic dysplasia', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'Wilson disease', 'X-linked spondyloepimetaphyseal dysplasia', 'hypoxanthine guanine phosphoribosyltransferase partial deficiency', 'Bruton-type agammaglobulinemia', 'X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia', 'combined immunodeficiency due to moesin deficiency', 'Wiskott-Aldrich syndrome', 'Aarskog-Scott syndrome, X-linked', 'hyper-IgM syndrome type 1', 'Melnick-Needles syndrome', 'Bartsocas-Papas syndrome 1', 'pulmonary venoocclusive disease', 'spondyloepimetaphyseal dysplasia, Irapa type', 'SHOX-related short stature', 'immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'spondyloepiphyseal dysplasia tarda, X-linked', 'T-B+ severe combined immunodeficiency due to JAK3 deficiency', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'skeletal dysplasia-epilepsy-short stature syndrome', 'hereditary mixed polyposis syndrome', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive', 'Ehlers-Danlos syndrome, musculocontractural type', 'spondyloepimetaphyseal dysplasia, Missouri type', 'axial spondylometaphyseal dysplasia', 'severe combined immunodeficiency due to DCLRE1C deficiency', 'spondyloepimetaphyseal dysplasia, Shohat type', 'myotonic dystrophy type 2', 'radioulnar synostosis-microcephaly-scoliosis syndrome', 'spondyloepimetaphyseal dysplasia with multiple dislocations', 'Omenn syndrome', 'xanthinuria type II', 'autoimmune lymphoproliferative syndrome type 2A', 'nephronophthisis 3', 'pyogenic arthritis-pyoderma gangrenosum-acne syndrome', 'hyper-IgM syndrome type 2', 'immunodeficiency due to CD25 deficiency', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'hyper-IgM syndrome type 3', 'multiple epiphyseal dysplasia type 5', 'anauxetic dysplasia', 'autoimmune lymphoproliferative syndrome type 2B', 'Smith-McCort dysplasia 1', 'granular corneal dystrophy type II', 'acrocapitofemoral dysplasia', 'endometrial cancer', 'hyper-IgM syndrome type 5', 'hyper-IgM syndrome type 4', 'neutrophil immunodeficiency syndrome', 'familial adenomatous polyposis 2', 'spondyloepimetaphyseal dysplasia, matrilin-3 type', 'familial avascular necrosis of femoral head', 'immunodeficiency 104', 'spondylometaphyseal dysplasia, A4 type', 'epidermolysis bullosa simplex 7, with nephropathy and deafness', 'permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome', 'mesoaxial synostotic syndactyly with phalangeal reduction', 'hyperinsulinemic hypoglycemia, familial, 4', 'Mungan syndrome', 'familial cold autoinflammatory syndrome 2', 'aortic aneurysm, familial thoracic 6', 'hypouricemia, renal, 2', 'dopa-responsive dystonia due to sepiapterin reductase deficiency', 'combined immunodeficiency due to STIM1 deficiency', 'atypical hemolytic-uremic syndrome with MCP/CD46 anomaly', 'atypical hemolytic-uremic syndrome with I factor anomaly', 'atypical hemolytic-uremic syndrome with B factor anomaly', 'atypical hemolytic-uremic syndrome with C3 anomaly', 'atypical hemolytic-uremic syndrome with thrombomodulin anomaly', 'lymphoproliferative syndrome 1', 'purine nucleoside phosphorylase deficiency', 'spondylo-megaepiphyseal-metaphyseal dysplasia', 'brachydactylous dwarfism, Mseleni type', 'spondyloepimetaphyseal dysplasia, Handigodu type', 'hemolytic anemia due to glucophosphate isomerase deficiency', 'alpha 1-antitrypsin deficiency', 'occult macular dystrophy', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'polyp', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'renal cell carcinoma', 'respiratory system disease', 'sarcoma', 'severe acute respiratory syndrome', 'Sjogren syndrome', 'skin disease', 'small cell lung carcinoma', 'rheumatoid arthritis', 'spindle cell tumor', 'spondyloarthropathy', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'systemic scleroderma', 'ulcerative colitis', 'uterine fibroid', 'melanoma', 'malignant peripheral nerve sheath tumor', 'viral disease', 'HIV infection', 'AIDS', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'temporal lobe epilepsy', 'myositis', 'leprosy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'Down syndrome', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'lung carcinoma', 'ovarian carcinoma', 'post-traumatic stress disorder', 'pulmonary arterial hypertension', 'synovial sarcoma', 'autosomal dominant polycystic liver disease', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'small intestinal neuroendocrine tumor G1', 'breast benign neoplasm', 'central nervous system primitive neuroectodermal neoplasm', 'vertebral column disorder', 'cerebral cavernous malformation', 'interstitial emphysema', 'gastric cancer', 'essential hypertension', 'hypertensive heart disease', 'familial hyperlipidemia', 'impaired renal function disease', 'myopia', 'nephrocalcinosis', 'leiomyoma', 'prolapse of female genital organ', 'brain cancer', 'nontoxic goiter', 'pure red-cell aplasia', 'crescentic glomerulonephritis', 'tuberous sclerosis', 'depressive disorder', 'ventricular septal defect', 'pneumothorax', 'Richter syndrome', 'thyroid cancer', 'giant cell tumor', 'spondylosis', 'papilloma', 'kidney cancer', 'dermatitis', 'prostatic adenoma', 'lobular neoplasia', 'gingival overgrowth', 'papillary adenocarcinoma', 'digestive system cancer', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratocarcinoma', 'teratoma', 'bone inflammation disease', 'small cell osteogenic sarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'anal canal adenocarcinoma', 'skin cancer', 'cerebellar neoplasm', 'cervical cancer', 'breast angiosarcoma', 'bile duct adenocarcinoma', 'thoracic cancer', 'colonic disorder', 'functioning pituitary gland adenoma', 'anal canal squamous cell carcinoma', 'pancreatic intraductal papillary-mucinous neoplasm', 'muscular atrophy', 'female breast carcinoma', 'retinal degeneration', 'MHC class II deficiency 4', 'immunodeficiency 122', 'inflammation', 'circulating fibrinogen levels', 'glomerular filtration rate', 'fat pad mass', 'hip circumference', 'bone tissue density', 'von Willebrand factor quality', 'waist circumference', 'age of onset of asthma', 'level of serum globulin type protein', 'red blood cell density', 'serum alanine aminotransferase amount', 'heart rate', 'age of onset of allergic disease', 'brain volume', 'serum albumin amount', 'serum creatinine amount', 'body height', 'cyst', 'X-linked hyper-IgM syndrome', 'Brachydactyly - elbow wrist dysplasia', 'Chronic mucocutaneous candidosis', 'Desbuquois syndrome', 'Chédiak-Higashi syndrome', 'Recurrent infection due to specific granule deficiency', 'Immunodeficiency syndrome with autoimmunity', 'Metaphyseal chondrodysplasia, Schmid type', 'Åland Islands eye disease', 'Ichthyosis - intellectual disability - dwarfism - renal impairment', 'Autosomal recessive early-onset inflammatory bowel disease', 'X-linked lymphoproliferative disease', 'Metaphyseal dysostosis - intellectual disability - conductive deafness', 'CHST3-related skeletal dysplasia', 'Cyclic neutropenia', 'Severe combined immunodeficiency due to adenosine deaminase deficiency', 'Aneurysm - osteoarthritis syndrome', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Multiple osteochondromas', 'Recurrent infections-myelofibrosis-nephromegaly syndrome', 'Acromesomelic dysplasia, Maroteaux type', 'Hyperlipoproteinemia type 1', 'X-linked agammaglobulinemia', 'Familial hemophagocytic lymphohistiocytosis', 'Immunodeficiency by defective expression of HLA class 2', 'Pyogenic arthritis - pyoderma gangrenosum - acne', 'Familial adenomatous polyposis', 'Thymic aplasia', 'Other metabolic disease', 'Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification', 'Hypohidrotic ectodermal dysplasia with immunodeficiency', 'Leukocyte adhesion deficiency type III', 'hematocrit', 'C-reactive protein measurement', 'glucose measurement', 'hemoglobin measurement', 'bone quantitative ultrasound measurement', 'triglyceride measurement', 'alkaline phosphatase measurement', 'creatine kinase measurement', 'cryptorchidism', 'total cholesterol measurement', 'gestational diabetes', 'low density lipoprotein cholesterol measurement', 'lymphocyte count', 'acute lung injury', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'cystatin C measurement', 'factor VII measurement', 'IGF-1 measurement', 'factor VIII measurement', 'white matter integrity', 'hip geometry', 'factor XI measurement', 'intraocular pressure measurement', 'sex hormone-binding globulin measurement', 'age at menarche', 'pelvic organ prolapse', 'FEV/FVC ratio', 'prion disease', 'aspartate aminotransferase measurement', 'protein measurement', 'neutrophil count', 'eosinophil count', 'lymph node metastatic carcinoma', 'appendicular lean mass', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'autoimmune disease', 'congenital heart disease', 'central corneal thickness', 'cholangiocarcinoma', 'reading', 'anxiety', 'primitive neuroectodermal tumor', 'aortic valve calcification', 'non-small cell lung adenocarcinoma', 'axial length measurement', 'contact dermatitis', 'vein disorder', 'in situ carcinoma', 'inborn disorder of amino acid metabolism', 'allergic asthma', 'fatty liver disease', 'alopecia', 'hypoplastic left heart syndrome', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'upper respiratory tract disorder', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'Parkinson disease', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'allergic disease', 'multiple sclerosis', 'skin basal cell carcinoma', 'childhood onset asthma', 'colorectal cancer', 'Lynch syndrome', 'Wilms tumor', 'prune belly syndrome', 'Adams-Oliver syndrome', 'Acropectorovertebral dysplasia', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency', 'Tietz syndrome', 'autosomal dominant Alport syndrome', 'Townes-Brocks syndrome', 'atelosteogenesis type III', 'Osebold-Remondini syndrome', 'brachydactyly type C', 'autosomal dominant brachyolmia', 'Gordon syndrome', 'breast cancer', 'chondrocalcinosis 2', 'congenital contractural arachnodactyly', 'fleck corneal dystrophy', 'Duane retraction syndrome', 'Leri-Weill dyschondrosteosis', 'Beckwith-Wiedemann syndrome', 'esophageal cancer', 'autoinflammatory syndrome, familial, X-linked, Behcet-like 2', 'immunodeficiency 98 with autoinflammation, X-linked', 'metastatic malignant neoplasm', 'granulomatous disease, chronic, autosomal recessive, 5', 'hyper-IgE recurrent infection syndrome 5, autosomal recessive', 'immunodeficiency 81', 'immunodeficiency 82 with systemic inflammation', 'inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive', 'immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias', 'immunodeficiency 75', 'immunodeficiency 76', 'nephrotic syndrome 16', 'immunodeficiency 69', 'immunodeficiency 78 with autoimmunity and developmental delay', 'immunodeficiency 70', 'immunodeficiency 72 with autoinflammation', 'immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia', 'autoinflammation, immune dysregulation, and eosinophilia', 'severe combined immunodeficiency due to CD70 deficiency', 'myofibroblastoma', 'invasive carcinoma', 'adenoviridae infectious disease', 'brain injury', 'nosocomial infection', 'enteritis', 'ulcer disease', 'radiation pneumonitis', 'familial adenomatous polyposis 4', 'severe combined immunodeficiency due to LAT deficiency', 'desmoplastic melanoma', 'myelofibrosis', 'salivary duct carcinoma', 'oral cavity carcinoma', 'rectal carcinoma', 'vertebral disorder', 'digestive system melanoma', 'short-rib thoracic dysplasia 17 with or without polydactyly', 'platelet abnormalities with eosinophilia and immune-mediated inflammatory disease', 'COVID-19', 'liver failure', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'spondyloepimetaphyseal dysplasia', 'gastrointestinal defects and immunodeficiency syndrome 1', 'immunodeficiency 105', 'autoinflammatory disease, X-linked', 'autoinflammatory syndrome with immunodeficiency', 'achalasia-alacrima syndrome', 'choroidal neovascularization', 'rhizomelic dysplasia, Ain-Naz type', 'autoinflammatory disease, multisystem, with immune dysregulation, X-linked', 'hyper-IgE syndrome 6, autosomal dominant, with recurrent infections', 'immunodeficiency 113 with autoimmunity and autoinflammation', 'immunodeficiency 117', 'neutropenia, severe congenital, 11, autosomal dominant', 'autoinflammation with episodic fever and immune dysregulation', 'immunodeficiency 119', 'postmenopausal osteoporosis', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'ankylosing spondylitis', 'deep vein thrombosis', 'angina pectoris', 'atherosclerosis', 'necrotizing enterocolitis', 'gastroesophageal reflux disease', 'seasonal allergic rhinitis', 'breast neoplasm', 'left ventricular hypertrophy', 'stomach neoplasm', 'obstructive sleep apnea', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'neuropathy', 'open-angle glaucoma', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Vitiligo', 'hypospadias', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'exfoliation syndrome', 'focal segmental glomerulosclerosis', 'chronic hepatitis B virus infection', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'meningococcal infection', 'membranous glomerulonephritis', 'nephrotic syndrome', 'osteonecrosis', 'bone disease', 'vascular disease', 'peripheral arterial disease', 'sclerosing cholangitis', 'scoliosis', 'brain infarction', 'thoracic aortic aneurysm', 'ventricular fibrillation', 'colonic neoplasm', 'erythrocyte count', 'platelet count', 'vital capacity', 'forced expiratory volume', 'smoking behavior', 'body weight', 'body mass index', 'body fat distribution', 'waist-hip ratio', 'corneal topography', 'neuroimaging measurement', 'metastatic neoplasm', 'wheezing', 'enthesitis-related juvenile idiopathic arthritis', 'Chronic Obstructive Asthma', 'carotid atherosclerosis', 'pulse wave reflection index measurement', 'total hip arthroplasty', 'kidney injury', 'muscle atrophy', 'chromosomal aberration frequency', 'bone metastasis', 'HMG CoA reductase inhibitor use measurement', 'Inhalant adrenergic use measurement', 'Glucocorticoid use measurement', 'low density lipoprotein triglyceride measurement', 'diverticular disease', 'corneal resistance factor', 'citrate measurement', 'cholesteryl ester measurement', 'glucuronate measurement', 'isocitrate measurement', 'atopic asthma', 'coinfection', 'total joint arthroplasty', 'aspartate aminotransferase to alanine aminotransferase ratio', 'nephrotoxicity', 'inflammatory bowel disease, immunodeficiency, and encephalopathy', 'severe malarial anemia', 'total knee arthroplasty', 'palmitate 16:0 measurement', 'sexual dimorphism measurement', 'body surface area', 'serum lipopolysaccharide activity', 'Birt-Hogg-Dube syndrome', '25-hydroxyvitamin D3 measurement', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'granulosa cell tumor', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'pulmonary tuberculosis', 'tongue squamous cell carcinoma', 'nasopharyngeal squamous cell carcinoma', 'Acute Leukemia', 'Ampulla of Vater Carcinoma', 'Appendix Adenocarcinoma', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Cavernous Hemangioma', 'Central Nervous System Lymphoma', 'Cervical Adenosquamous Carcinoma', 'cervical squamous cell carcinoma', 'Colon Dysplasia', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Endometrial Undifferentiated Carcinoma', 'Fibroblastic Neoplasm', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'nonpapillary renal cell carcinoma', 'Pallister-Hall syndrome', 'periodic fever, immunodeficiency, and thrombocytopenia syndrome', 'platyspondylic dysplasia, Torrance type', 'systemic lupus erythematosus', 'Marfan syndrome', 'melorheostosis', 'mesomelic dysplasia, Kantaputra type', 'metatropic dysplasia', 'Mobius syndrome', 'Muir-Torre syndrome', 'Cowden syndrome 1', 'myotonic dystrophy type 1', 'nail-patella syndrome', 'autosomal dominant progressive nephropathy with hypertension', 'ovarian cancer', 'Peyronie disease', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'Hutchinson-Gilford progeria syndrome', 'familial juvenile hyperuricemic nephropathy type 1', 'Peutz-Jeghers syndrome', 'prostate cancer', 'pseudoachondroplasia', 'autosomal dominant distal renal tubular acidosis', 'retinoblastoma', 'Smith-Magenis syndrome', 'spondyloepiphyseal dysplasia tarda, autosomal dominant', 'spondyloepimetaphyseal dysplasia, Strudwick type', 'spondylometaphyseal dysplasia, Kozlowski type', 'spondylometaphyseal dysplasia, Schmidt type', 'proximal symphalangism', 'syndactyly type 5', 'brachydactyly-elbow wrist dysplasia syndrome', 'tarsal-carpal coalition syndrome', 'thoracolaryngopelvic dysplasia', 'tooth and nail syndrome', 'volvulus of midgut', 'short-limb skeletal dysplasia with severe combined immunodeficiency', 'acrocallosal syndrome', 'acrodermatitis enteropathica', 'acromesomelic dysplasia 2C, Hunter-Thompson type', 'agnathia-otocephaly complex', 'autosomal recessive Alport syndrome', 'amelogenesis imperfecta type 1G', 'microphthalmia with limb anomalies', 'progressive pseudorheumatoid arthropathy of childhood', 'Bloom syndrome', 'kyphomelic dysplasia', 'lung cancer', 'heart defects-limb shortening syndrome', 'chordoma', 'Juberg-Hayward syndrome', 'Costello syndrome', 'cystic fibrosis', 'hereditary renal hypouricemia', 'diastrophic dysplasia', 'Dyggve-Melchior-Clausen disease', 'Ehlers-Danlos syndrome, dermatosparaxis type', 'multiple epiphyseal dysplasia type 4', 'classic Hodgkin lymphoma', 'immunodeficiency, common variable, 2', 'ichthyosis-intellectual disability-dwarfism-renal impairment syndrome', 'Nezelof syndrome', 'spondylometaphyseal dysplasia, Sedaghatian type', 'metaphyseal dysostosis-intellectual disability-conductive deafness syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'carnitine palmitoyl transferase II deficiency, myopathic form', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'nail-patella-like renal disease', 'nephronophthisis 1', 'congenital nephrotic syndrome, Finnish type', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'human papilloma virus infection', 'fibrosarcoma', 'benign neoplasm', 'hypertrophy', 'anaplastic astrocytoma', 'cardiac hypertrophy', 'medical procedure', 'AIDS dementia', 'juvenile idiopathic arthritis', 'insulin resistance', 'prostate intraepithelial neoplasia', 'septic peritonitis', 'vulvar intraepithelial neoplasia', 'renal carcinoma', 'thyroid carcinoma', 'metastatic melanoma', 'pancreatic carcinoma', 'rotavirus infection', 'Cutaneous T-cell lymphoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'muscular disease', 'transitional cell carcinoma of kidney', 'anaplastic large cell lymphoma', 'bacteriemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'peripheral neuropathy', 'testicular seminoma', 'pneumonia', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'refractory anemia with ringed sideroblasts', 'laryngeal neoplasm', 'lung disease', 'brain neoplasm', 'calcification', 'retinopathy', 'thyroid neoplasm'], tissue_specific_expression={'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\"small intestine Peyer's patch\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}, is_essential=False, genetic_constraint={'syn': -0.12650999426841736, 'mis': 4.360300064086914, 'lof': 0.9999799728393555}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.', '*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'breast\\\\': 0, \\\\'atrium auricular region\\\\': 1, \\\\'liver\\\\': 0, \\\\'skeletal muscle tissue\\\\': 1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\\'esophagus mucosa\\\\': 1, \\\\'macrophage\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'segmented neutrophil of bone marrow\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': -1, \\\\'class switched memory B cell\\\\': 0, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 3, \\\\'Brodmann (1909) area 9\\\\': 0, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 1, \\\\'zone of skin\\\\': 1, \\\\'leukocyte\\\\': 0, \\\\'nasopharynx\\\\': -1, \\\\'tonsil\\\\': 0, \\\\'frontal lobe\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'putamen\\\\': 0, \\\\'hematopoietic stem cell\\\\': -1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'testis\\\\': -1, \\\\'bronchus\\\\': -1, \\\\'sigmoid colon\\\\': 0, \\\\'fallopian tube\\\\': 0, \\\\'plasma cell\\\\': -1, \\\\'aorta\\\\': 0, \\\\'adrenal gland\\\\': -1, \\\\'kidney\\\\': 0, \\\\'endometrium\\\\': 0, \\\\'smooth muscle tissue\\\\': 0, \\\\'tibial artery\\\\': 0, \\\\'prefrontal cortex\\\\': 0, \\\\'CD8-positive, alpha-beta T cell\\\\': -1, \\\\'vermiform appendix\\\\': 0, \\\\'lymph node\\\\': 0, \\\\'duodenum\\\\': 0, \\\\'mature eosinophil\\\\': 0, \\\\'prostate gland\\\\': 1, \\\\'C1 segment of cervical spinal cord\\\\': -1, \\\\'lung\\\\': 0, \\\\'inflammatory macrophage\\\\': -1, \\\\'rectum\\\\': 0, \\\\'suprapubic skin\\\\': 0, \\\\'brain\\\\': -1, \\\\'coronary artery\\\\': 0, \\\\'parathyroid gland\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': 0, \\\\'esophagus muscularis mucosa\\\\': 0, \\\\'esophagus\\\\': 1, \\\\'transformed skin fibroblast\\\\': 1, \\\\'heart muscle\\\\': -1, \\\\'pancreas\\\\': 0, \\\\'uterus\\\\': 0, \\\\'placenta\\\\': 0, \\\\'seminal vesicle\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'endothelial cell of umbilical vein (resting)\\\\': 0, \\\\'minor salivary gland\\\\': 0, \\\\'endocervix\\\\': 1, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'CD8-positive, alpha-beta thymocyte\\\\': -1, \\\\'granulocyte monocyte progenitor cell\\\\': -1, \\\\'caudate nucleus\\\\': 0, \\\\'amygdala\\\\': 0, \\\\'temporal lobe\\\\': 0, \\\\'substantia nigra\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'common lymphoid progenitor\\\\': 0, \\\\'cerebral cortex\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 0, \\\\'blood\\\\': -1, \\\\'nucleus accumbens\\\\': 0, \\\\'stomach\\\\': 0, \\\\'oral mucosa\\\\': -1, \\\\'mature neutrophil\\\\': 0, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'bone marrow\\\\': -1, \\\\'gall bladder\\\\': 1, \\\\'colon\\\\': 0, \\\\'cytotoxic CD56-dim natural killer cell\\\\': -1, \\\\'pituitary gland\\\\': 0, \\\\'transverse colon\\\\': 0, \\\\'heart left ventricle\\\\': 0, \\\\'erythroblast\\\\': -1, \\\\'vagina\\\\': 1, \\\\'ovary\\\\': 1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': 1, \\\\'cerebellum\\\\': -1, \\\\'hypothalamus\\\\': -1, \\\\'common myeloid progenitor\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': -1, \\\\'alternatively activated macrophage\\\\': -1, \\\\'thyroid gland\\\\': 1, \\\\'lower leg skin\\\\': 0, \\\\'epididymis\\\\': -1, \\\\'spleen\\\\': 0, \\\\'esophagogastric junction\\\\': 0, \\\\'greater omentum\\\\': 1, \\\\'memory B cell\\\\': 0, \\\\'hippocampus proper\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': -1, \\\\'small intestine\\\\': 1, \\\\'conventional dendritic cell\\\\': -1, \\\\'cortex of kidney\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": 0, \\\\'heart\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': -1, \\\\'caudate-putamen\\\\': -1, \\\\'urinary bladder\\\\': 1, \\\\'ectocervix\\\\': 1, \\\\'regulatory T cell\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 1, \\\\'saliva-secreting gland\\\\': 0, \\\\'neutrophilic metamyelocyte\\\\': -1, \\\\'tibial nerve\\\\': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets'])}\\n*NAME* humanbase_functions\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': ['SMAD2', 'SMAD3'], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id='Q15796', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma'], diseases=['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], pathways=['SMAD2/3 Phosphorylation Motif Mutants in Cancer', 'Developmental Biology', 'Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer', 'Deubiquitination', 'TGF-beta receptor signaling activates SMADs', 'Signaling by TGFB family members', 'Loss of Function of TGFBR1 in Cancer', 'Signaling by TGF-beta Receptor Complex', 'TGFBR1 KD Mutants in Cancer', 'Post-translational protein modification', 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes', 'Disease', 'Generic Transcription Pathway', 'Metabolism of proteins', 'Gene expression (Transcription)', 'Signal Transduction', 'FOXO-mediated transcription', 'Gastrulation', 'RNA Polymerase II Transcription', 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription', 'FOXO-mediated transcription of cell cycle genes', 'Loss of Function of SMAD2/3 in Cancer', 'Transcriptional regulation of pluripotent stem cells', 'SMAD4 MH2 Domain Mutants in Cancer', 'Diseases of signal transduction by growth factor receptors and second messengers', 'Formation of axial mesoderm', 'Germ layer formation at gastrulation', 'Downregulation of TGF-beta receptor signaling', 'Formation of definitive endoderm', 'Ub-specific processing proteases', 'Loss of Function of SMAD4 in Cancer', 'Downregulation of SMAD2/3:SMAD4 transcriptional activity', 'SMAD2/3 MH2 Domain Mutants in Cancer', 'Signaling by Activin', 'Signaling by TGF-beta Receptor Complex in Cancer', 'Signaling by NODAL'], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['SMAD3', 'SMAD4', 'SMURF2'], 'Affinity Capture-MS': ['ARID1A', 'ARID1B', 'ASH2L', 'ATAD3B', 'BCL7A', 'BTBD9', 'BUB3', 'C1ORF116', 'CAD', 'CCT6A', 'CDC27', 'CGA', 'CPSF7', 'CREBBP', 'CSNK1D', 'CTNNB1', 'CUL4A', 'CUL4B', 'DCAF7', 'DDX3Y', 'DGKA', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'EPB41L5', 'ERBB2IP', 'EZH2', 'FAM83G', 'FLOT1', 'FLOT2', 'FYN', 'GSK3A', 'GTF3C2', 'GTF3C6', 'HCFC1', 'HDAC2', 'HDAC4', 'HINT3', 'HSPA4', 'ITGB4', 'KLF5', 'KMT2C', 'LDLRAD4', 'LEMD3', 'MED15', 'MED16', 'MED17', 'MED19', 'MED20', 'MED22', 'MED25', 'MED31', 'MED4', 'MED9', 'MEN1', 'MTMR4', 'NCOA3', 'OGT', 'OPA1', 'OTUB1', 'PARK2', 'PCBP1', 'PCID2', 'PLEKHA4', 'PSPC1', 'RIN1', 'SGSH', 'SIK3', 'SKI', 'SKIL', 'SLC25A3', 'SLC25A5', 'SLC25A6', 'SMAD1', 'SMAD3', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMARCD2', 'SMPDL3B', 'SMURF2', 'SNW1', 'SNX27', 'SQRDL', 'TAF1', 'TAF2', 'TAF3', 'TAF5', 'TAF6', 'TMED8', 'TMOD1', 'TRIM28', 'TRIM33', 'TRIM67', 'U2AF2', 'WDR82', 'WRNIP1', 'WWP2', 'YAF2', 'YY1', 'ZFYVE9'], 'Affinity Capture-RNA': ['DDX58', 'ELAVL1'], 'Affinity Capture-Western': ['ACVR1B', 'ACVR2B', 'AKT1', 'ANAPC10', 'ATF3', 'BRCA2', 'CDC16', 'CDC27', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DAB2', 'DOCK9', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'ETV4', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'FOXP1', 'GLI1', 'GTF2I', 'GTF2IRD1', 'HDAC1', 'HGS', 'HYAL2', 'ING2', 'INSR', 'IRF3', 'IRF7', 'ITCH', 'JUN', 'KAT2A', 'KAT2B', 'KDM6B', 'KLF5', 'LEF1', 'MAPT', 'MED15', 'MED24', 'MED6', 'MEF2A', 'METTL14', 'METTL3', 'MYC', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFYC', 'NOTCH4', 'NUP214', 'OTUB1', 'OVOL2', 'PIAS3', 'PIAS4', 'PIN1', 'PML', 'PRDM16', 'RBBP5', 'RELB', 'RGCC', 'RNF111', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD6', 'SMAD7', 'SMARCA4', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'STRAP', 'TCF12', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TP53', 'TRIM28', 'TRIM33', 'TSC2', 'UCHL1', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWP1', 'WWP2', 'YAP1', 'ZEB1', 'ZFYVE9'], 'Biochemical Activity': ['ACVR1B', 'CAMK2G', 'CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'ITCH', 'TGFBR1'], 'Co-crystal Structure': ['SMAD4'], 'Co-fractionation': ['AP1M1', 'ARID1B', 'CAV1', 'CREBBP', 'CTNNB1', 'HDAC1', 'HMGA2', 'MTA2', 'NAA15', 'NCOA3', 'PARP1', 'PML', 'PRKDC', 'RBM14', 'RELA', 'SMAD3', 'SMAD4', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SUB1', 'TGFBR1', 'TRIM33', 'XRCC6', 'ZFYVE9'], 'Co-localization': ['CAMK2A', 'TGFBR1', 'TP53'], 'FRET': ['BECN1', 'LATS2', 'MYC', 'SMAD1'], 'Phenotypic Enhancement': ['SMAD3', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['SPPL3'], 'Proximity Label-MS': ['CCNF', 'EPHA2', 'OPTN', 'RAB7A', 'SNCA', 'TGOLN2'], 'Reconstituted Complex': ['ANAPC10', 'ANP32B', 'ANP32E', 'ATP5I', 'BPTF', 'CREBBP', 'DAB2', 'DVL1', 'ELAC2', 'ERBB2IP', 'ESR1', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'HDAC2', 'HIPK2', 'HYAL2', 'INSR', 'IRF7', 'JUN', 'KAT2B', 'LCK', 'LEF1', 'MECOM', 'MEF2A', 'MEF2C', 'MYC', 'MYOCD', 'NEDD4L', 'NEFM', 'NFIA', 'NUP214', 'OTUB1', 'PARD3', 'PIAS3', 'PIK3CA', 'PIN1', 'PTMS', 'RHOA', 'SH2D2A', 'SKI', 'SMAD4', 'SMAD7', 'SMURF2', 'SNW1', 'SOD1', 'SP1', 'STUB1', 'SYT1', 'TP53', 'TUBA1B', 'UCHL5', 'YY1', 'ZFYVE9'], 'Two-hybrid': ['ABTB1', 'AKT1', 'ANAPC2', 'ANK3', 'ANTXR2', 'BAZ1A', 'BTBD2', 'C22ORF46', 'C9ORF156', 'CISH', 'COPS5', 'CORO2A', 'CREBBP', 'CSH1', 'CSH2', 'CUL5', 'CYLC2', 'CYP11A1', 'DCUN1D1', 'DNAJB5', 'DNAJC7', 'DOCK8', 'DYNC1H1', 'DYRK1A', 'EEF1A1', 'EIF3L', 'EP300', 'ETV4', 'FAM161B', 'FBP2', 'FOXH1', 'GATAD2B', 'GFER', 'HSD17B3', 'INSR', 'KHDRBS1', 'KIAA1033', 'KPNB1', 'LAMA5', 'LEMD3', 'MAP2K1', 'MLLT4', 'MYC', 'NAGK', 'NCOA6', 'NEDD4L', 'OS9', 'PAPOLA', 'PAPPA', 'PAXIP1', 'PEX19', 'PIAS4', 'PLIN3', 'POU2AF1', 'PPP2R1A', 'PRKAR1A', 'PSAP', 'PSG9', 'PSMD11', 'PSMD8', 'RANBP6', 'RANBP9', 'RARB', 'RASA1', 'RNF123', 'RNPC3', 'ROCK1', 'RPS14', 'RPS27A', 'RXRA', 'SKI', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD9', 'SMURF1', 'SMURF2', 'SNAPIN', 'SNIP1', 'SNRNP70', 'SNW1', 'SP1', 'SRI', 'ST13', 'ST5', 'TBC1D1', 'TGIF1', 'TGM2', 'TRIM62', 'UBA52', 'UBR5', 'XPA', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF41', 'ZNF510', 'ZNHIT6']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF1', 'ARHGEF6', 'ARHGEF7', 'ARL4D', 'CDC40', 'FBXO3', 'IRAK2', 'LHX9', 'LMO2', 'MAP2K3', 'NUAK2', 'PPP2R2D', 'RAB34', 'RAB38', 'RASD2', 'RGS3', 'RHEBL1', 'RHOBTB1', 'RHOD', 'RHOJ', 'RPS27A', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'UHMK1', 'WWP2'], 'Affinity Capture-MS': ['ALDH4A1', 'BACH1', 'E6', 'FANCD2', 'NSP16AB', 'OTUB1', 'PAXIP1', 'RUNX1'], 'Affinity Capture-Western': ['COL1A1', 'COL3A1', 'COL5A1', 'DOK1', 'E6', 'E7', 'GATA4', 'HCVGP1', 'KAP-ALPHA3', 'KLF4', 'LEF1', 'MED', 'MED15', 'MEF2A', 'RNF111', 'SKI', 'SMAD2', 'SMAD4', 'SMOX', 'SNOO', 'UBX', 'VIS', 'WWTR1', 'YAP1'], 'Co-localization': ['E7', 'EZH2-A', 'KLF4'], 'PCA': ['E6', 'SMOX'], 'Phenotypic Enhancement': ['BABO', 'INR', 'SMOX', 'YKI'], 'Phenotypic Suppression': ['BABO', 'HPO', 'INR', 'MYO', 'PLUM', 'PTEN', 'SCGDELTA', 'SMOX'], 'Reconstituted Complex': ['E7', 'LEMD3', 'SMAD2', 'SOX9', 'UBX', 'ZFP128'], 'Two-hybrid': ['CG18095', 'D', 'E6', 'EG', 'FOXH1', 'HOXA13', 'HOXD13', 'HR78', 'SMAD2', 'SMOX', 'UBX', 'ZEB2', 'ZEN']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Overgrowth', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Myocardial fibrosis', 'Increased total eosinophil count', 'Thrombocytosis', 'Anemia', 'Acute kidney injury', 'Glucose intolerance', 'Pulmonary hypoplasia', 'Pneumonia', 'Asthma', 'Ischemic stroke', 'Cerebral ischemia', 'Vascular dilatation', 'Aortic dissection', 'Systemic lupus erythematosus', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Skeletal muscle atrophy', 'Muscular dystrophy', 'Cachexia', 'Thrombophlebitis', 'Miscarriage', 'Ureteral obstruction', 'Airway obstruction', 'Amyotrophic lateral sclerosis', 'Peripheral demyelination', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Reduced sperm motility', 'Urethral stricture', 'Renal atrophy', 'Cervical polyp', 'Shock', 'Granuloma', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Sepsis', 'geleophysic dysplasia', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'hydronephrosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'renal cell adenocarcinoma', 'Autoimmune Hepatitis', 'neurodegenerative disease', 'brain disease', 'aortic disease', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'head and neck neoplasia', 'breast ductal adenocarcinoma', 'laryngeal squamous cell carcinoma', 'ovarian adenocarcinoma', 'ovarian mucinous adenocarcinoma', 'ovarian teratoma', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'dysplastic oral keratinocyte', 'undifferentiated carcinoma', 'cerebral amyloid angiopathy', 'head and neck malignant neoplasia', 'breastfeeding duration', 'urgency urinary incontinence', 'fibrosis', 'Balkan nephropathy', 'congenital rubella', 'echinococcosis', 'Gerstmann syndrome', 'inclusion body myositis', 'muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10', 'severe neurodegenerative syndrome with lipodystrophy', 'Diamond-Blackfan anemia', 'cardiofaciocutaneous syndrome', 'adrenomyeloneuropathy', 'hereditary sensory and autonomic neuropathy', 'nasopharyngeal carcinoma', 'keratoconus', 'dentin dysplasia', 'T-cell non-Hodgkin lymphoma', 'dyskeratosis congenita', 'pneumoconiosis', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'cryopyrin-associated periodic syndrome', 'holoprosencephaly', 'pachyonychia congenita', 'familial rhabdoid tumor', 'familial hyperaldosteronism', 'primary ciliary dyskinesia', 'meningioma', 'pilocytic astrocytoma', 'hemangioblastoma', 'microcephaly-brain defect-spasticity-hypernatremia syndrome', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'heritable pulmonary arterial hypertension', 'juvenile polyposis syndrome', 'congenital herpes simplex virus infection', 'popliteal pterygium syndrome', 'ameloblastoma', 'hypersensitivity pneumonitis', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'emphysema', 'epilepsy', 'esophageal adenocarcinoma', 'fetal growth restriction', 'follicular thyroid adenoma', 'ganglioneuroma', 'follicular thyroid carcinoma', 'gastric adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'genetic disorder', 'germ cell tumor', 'glioblastoma multiforme', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'large cell neuroendocrine carcinoma', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'neural tube defect', 'tuberculosis', 'glioblastoma', 'carcinoma of liver and intrahepatic biliary tract', 'hereditary nonpolyposis colon cancer', 'Zika virus infectious disease', 'left ventricular noncompaction', 'multiminicore myopathy', 'Loeys-Dietz syndrome', 'neurofibromatosis type 1', 'Leber congenital amaurosis', 'osteogenesis imperfecta', 'progressive supranuclear palsy', 'intrahepatic cholestasis', 'lymphedema', 'posterior cortical atrophy', 'follicular lymphoma', 'kidney Wilms tumor', 'bronchopulmonary dysplasia', 'sarcoidosis', 'peeling skin syndrome', 'lissencephaly with cerebellar hypoplasia', 'aggressive NK-cell leukemia', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'familial thoracic aortic aneurysm and aortic dissection', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'precursor B-cell acute lymphoblastic leukemia', 'superficial spreading melanoma', 'lung neoplasm', 'intestinal neoplasm', 'odontogenic neoplasm', 'disorder of ear', 'endometrium neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'carcinoma of pharynx', 'polyp of colon', 'low grade glioma', 'corticobasal degeneration disorder', 'cervical intraepithelial neoplasia', 'viral myocarditis', 'lip and oral cavity carcinoma', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'chondrogenic neoplasm', 'intraepithelial neoplasia', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'pulmonary sarcoidosis', 'gonorrhea', 'B-cell acute lymphoblastic leukemia', 'chronic lymphocytic leukemia', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'myelodysplastic syndrome', 'oral squamous cell carcinoma', 'gastritis', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'acute promyelocytic leukemia', 'adenocarcinoma', 'adenoma', 'age', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', \\\"Barrett's esophagus\\\", 'benign prostatic hyperplasia', 'bladder tumor', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'central nervous system cancer', 'chondrosarcoma', 'chromophobe renal cell carcinoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'clear cell renal carcinoma', 'endometrial carcinoma', 'ovarian serous carcinoma', 'renal fibrosis', 'Abruptio Placentae', 'Adenomyosis', 'Carcinoma, Lewis Lung', 'chronic myelomonocytic leukemia', 'Marchiafava-Bignami Disease', 'oral submucous fibrosis', 'osteoradionecrosis', 'renal nutcracker syndrome', 'amyloidosis', 'mucositis', 'neuroendocrine neoplasm', 'neuromuscular disease', 'oral mucositis', 'Spinal cord injury', 'cutaneous squamous cell carcinoma', 'Barrett adenocarcinoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'pharyngeal squamous cell carcinoma', 'soft tissue sarcoma', 'undifferentiated pleomorphic sarcoma', 'connective tissue disease', 'pneumonitis', 'intrahepatic cholangiocarcinoma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'glomerular disease', 'nephritis', 'Neurogenic bladder', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Uterine leiomyoma', 'Cleft palate', 'Hydrocephalus', 'Cataract', 'Myopia', 'Autism', 'Infertility', 'Diabetes mellitus', 'Insulin resistance', 'Osteoporosis', 'Hyperkeratosis', 'Intellectual disability', 'Ataxia', 'Mental deterioration', 'Stroke', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Hepatic steatosis', 'Obesity', 'mixed connective tissue disease', 'pneumocystosis', 'pseudomyxoma peritonei', 'silicosis', 'toxoplasmosis', 'hemoglobin A1 measurement', 'BMI-adjusted waist-hip ratio', 'liver dysplastic nodule', 'gut microbiome measurement', 'platelet crit', 'allergen exposure measurement', 'calf circumference measurement', 'dysplasia', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'digestive system neoplasm', 'Hepatobiliary Neoplasm', 'American trypanosomiasis', 'acute myocardial infarction', 'pemphigus foliaceus', 'cystic kidney disease', 'Polycystic Kidney Disease', 'arteriosclerosis', 'hyperuricemia', 'skin carcinoma', 'heel bone mineral density', 'pulmonary fibrosis', 'hyperaldosteronism', 'gastric ulcer', 'infarction', 'aortic valve disease', 'heart valve disease', 'mitral valve disease', 'urinary tract obstruction', 'prostate disease', 'stomach disease', 'myocarditis', 'aneurysm', 'enthesopathy', 'musculoskeletal system disease', 'metastasis', 'Gallbladder Adenocarcinoma', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Malignant Mesothelioma', 'Malignant Pancreatic Neoplasm', 'Medullomyoblastoma with Myogenic Differentiation', 'Microcystic Meningioma', 'Mixed Tumor of the Salivary Gland', 'Nasal Cavity Polyp', 'Osteoblastoma', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Paraganglioma', 'Placental Choriocarcinoma', 'Rectal Tubular Adenoma', 'Sarcomatoid Carcinoma', 'Signet Ring Cell Gastric Adenocarcinoma', 'Synovial Chondromatosis', 'Testicular Non-Seminomatous Germ Cell Tumor', 'Testicular Yolk Sac Tumor', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vulvar Squamous Cell Carcinoma', 'acute respiratory distress syndrome', 'sarcopenia', 'rectum cancer', 'acanthosis nigricans', 'mucous membrane pemphigoid', 'punctate palmoplantar keratoderma type III', 'adrenal cortex carcinoma', 'alcoholic liver cirrhosis', 'atrophic gastritis', 'dental fluorosis', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'multiple system atrophy', 'myeloid sarcoma', 'nodular goiter', 'periapical granuloma', 'pulmonary edema', 'renovascular hypertension', 'retinopathy of prematurity', 'rheumatic heart disease', 'thromboangiitis obliterans', 'tooth disease', 'uremia', 'non-alcoholic steatohepatitis', 'Cryptogenic Organizing Pneumonia', 'Fascioliasis', 'Follicular Cyst', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Myocardial Ischemia', 'Pelvic Inflammatory Disease', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Pneumonia, Aspiration', 'Respiratory Syncytial Virus Infection', 'diabetic cardiomyopathy', 'diabetic foot', 'endothelial dysfunction', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'schistosomiasis', 'abortion', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'Bartsocas-Papas syndrome 1', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'SHOX-related short stature', 'intellectual disability, X-linked syndromic, Turner type', 'Fabry disease', 'X-linked corneal dermoid', 'Aarskog-Scott syndrome, X-linked', 'holoprosencephaly-hypokinesia-congenital contractures syndrome', 'Melnick-Needles syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'Wilson disease', 'adenomyosis', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'Ehlers-Danlos syndrome, musculocontractural type', 'tetrasomy 12p', 'sickle cell anemia', 'hypotonia-cystinuria syndrome', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'autoimmune lymphoproliferative syndrome type 2B', 'endometrial cancer', 'Loeys-Dietz syndrome 1', 'hyperinsulinemic hypoglycemia, familial, 4', 'preterm premature rupture of the membranes', 'Mungan syndrome', 'Crouzon syndrome-acanthosis nigricans syndrome', 'papillary renal cell carcinoma', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'pterygium', 'renal cell carcinoma', 'rheumatoid arthritis', 'sarcoma', 'severe acute respiratory syndrome', 'small cell lung carcinoma', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'spondyloarthropathy', 'stroke', 'subarachnoid hemorrhage', 'systemic scleroderma', 'ulcerative colitis', 'melanoma', 'hepatocellular adenoma', 'viral disease', 'HIV infection', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'pneumococcal infection', 'temporal lobe epilepsy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'malaria', 'folate deficiency', 'lung carcinoma', 'ovarian carcinoma', 'familial amyotrophic lateral sclerosis', 'pulmonary arterial hypertension', 'age-related macular degeneration', 'synovial sarcoma', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'villous adenoma', 'mucosal melanoma', 'ovarian clear cell cancer', 'central nervous system primitive neuroectodermal neoplasm', 'Crohn ileitis', 'vertebral column disorder', 'endometrial disorder', 'gastric cancer', 'penile cancer', 'myopia', 'pulmonary alveolar proteinosis', 'Chagas disease', 'leiomyoma', 'brain cancer', 'tuberous sclerosis', 'sick sinus syndrome', 'arteriovenous hemangioma/malformation', 'hypertensive heart disease', 'head and neck carcinoma', 'depressive disorder', 'pneumothorax', 'Richter syndrome', 'peritoneum cancer', 'thyroid cancer', 'disorder of sexual differentiation', 'vulvar melanoma', 'papilloma', 'rectosigmoid junction neoplasm', 'Treacher-Collins syndrome', 'prostatic acinar adenocarcinoma', 'gingival overgrowth', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratoma', 'bone inflammation disease', 'extraosseous osteosarcoma', 'chondroblastic osteosarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'lung benign neoplasm', 'skin cancer', 'cervical cancer', 'seminoma', 'breast angiosarcoma', 'cerebellar pilocytic astrocytoma', 'salivary gland adenoid cystic carcinoma', 'bile duct adenocarcinoma', 'gastroesophageal junction adenocarcinoma', 'thoracic cancer', 'acral lentiginous melanoma', 'endometrial mixed adenocarcinoma', 'female breast carcinoma', 'inflammation', 'erythrocyte volume', 'glomerular filtration rate', 'bone tissue density', 'progesterone amount', 'serum alanine aminotransferase amount', 'serum urea amount', 'serum creatinine amount', 'body height', 'cyst', 'Hypotonia - cystinuria syndrome', 'Chédiak-Higashi syndrome', 'Åland Islands eye disease', 'Hydrocephalus with stenosis of the aqueduct of Sylvius', 'Autoimmune lymphoproliferative syndrome with recurrent viral infections', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Persistent Müllerian duct syndrome', 'WHIM syndrome', 'Familial adenomatous polyposis', 'Other metabolic disease', 'hematocrit', 'C-reactive protein measurement', 'hematological measurement', 'alkaline phosphatase measurement', 'cryptorchidism', 'lymphocyte count', 'gestational diabetes', 'acute lung injury', 'serum gamma-glutamyl transferase measurement', 'HbA1c measurement', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'wet macular degeneration', 'insomnia', 'hypothyroidism', 'pelvic organ prolapse', 'metabolite measurement', 'eosinophil count', 'lymph node metastatic carcinoma', 'embryonal carcinoma', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'monocyte count', 'autoimmune disease', 'congenital heart disease', 'cholangiocarcinoma', 'human african trypanosomiasis', 'reading', 'congenital heart malformation', 'temporomandibular joint disorder', 'axial length measurement', 'myeloid leukemia', 'lupus erythematosus', 'allergic asthma', 'fatty liver disease', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'cataract', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'multiple sclerosis', 'skin basal cell carcinoma', 'brain glioma', 'colorectal cancer', 'Wilms tumor', 'Townes-Brocks syndrome', 'nevoid basal cell carcinoma syndrome', 'breast cancer', 'congenital contractural arachnodactyly', 'Duane retraction syndrome', 'dyschromatosis symmetrica hereditaria', 'metastatic malignant neoplasm', 'Loeys-Dietz syndrome 6', 'cervical squamous intraepithelial neoplasia', 'leukoplakia', 'spinal cord injury', 'ulcer disease', 'desmoplastic melanoma', 'myelofibrosis', 'oral cavity carcinoma', 'rectal carcinoma', 'hydrocephalus, congenital, 3, with brain anomalies', 'nasal cavity and paranasal sinus carcinoma', 'COVID-19', 'Dravet syndrome', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'achalasia-alacrima syndrome', 'metabolic bone disorder', 'congenital heart defects, multiple types, 8, with or without heterotaxy', 'postmenopausal osteoporosis', 'intestinal polyp', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'breast neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'stomach neoplasm', 'ankylosing spondylitis', 'ciliopathy', 'deep vein thrombosis', 'obstructive sleep apnea', 'necrotizing enterocolitis', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'atherosclerosis', 'open-angle glaucoma', 'androgenetic alopecia', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'focal segmental glomerulosclerosis', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'myeloproliferative disorder', 'nephrotic syndrome', 'vascular disease', 'thoracic aortic aneurysm', 'venous thromboembolism', 'platelet count', 'body mass index', 'neuroimaging measurement', 'metastatic neoplasm', 'whole body water mass', 'kidney injury', 'bone metastasis', 'gastrointestinal disease', 'aspartate aminotransferase to alanine aminotransferase ratio', 'urea measurement', 'viral load', '2-hydroxyacetaminophen sulfate measurement', 'aging', 'serum lipopolysaccharide activity', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'ependymoma', 'granulosa cell tumor', 'metaplastic breast carcinoma', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'ACTH-Producing Pituitary Gland Adenoma', 'Adenomatoid Odontogenic Tumor', 'Ampulla of Vater Carcinoma', 'Anal Squamous Cell Carcinoma', 'Anaplastic (Malignant) Meningioma', 'Appendix Adenocarcinoma', 'Appendix Goblet Cell Carcinoid', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Breast Carcinoma by Gene Expression Profile', 'cervical squamous cell carcinoma', 'Columnar Cell Hyperplasia of the Breast', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Extramammary Paget Disease', 'fibrodysplasia ossificans progressiva', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'Pallister-Hall syndrome', 'Nager acrofacial dysostosis', 'Marfan syndrome', 'Cowden syndrome 1', 'nail-patella syndrome', 'ovarian cancer', 'Andersen-Tawil syndrome', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'nonpapillary renal cell carcinoma', 'Mobius syndrome', 'Peyronie disease', 'prostate cancer', 'retinoblastoma', 'acrodermatitis enteropathica', 'mitochondrial DNA depletion syndrome 4a', 'Alstrom syndrome', 'anencephaly 1', 'microphthalmia with limb anomalies', 'Bloom syndrome', 'lung cancer', 'cerebrotendinous xanthomatosis', 'cystic fibrosis', 'recessive dystrophic epidermolysis bullosa', 'Haim-Munk syndrome', 'Laurence-Moon syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'ischemic cardiomyopathy', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'fibrosarcoma', 'hypertrophy', 'actinic keratosis', 'anaplastic astrocytoma', 'anaplastic oligodendroglioma', 'cardiac hypertrophy', 'AIDS dementia', 'pancreatic carcinoma', 'prostate intraepithelial neoplasia', 'thyroid carcinoma', 'insulin resistance', 'esophageal carcinoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'acute megakaryoblastic leukaemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'pleomorphic liposarcoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'Pick disease', 'testicular seminoma', 'osteomyelitis', 'spina bifida', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'lung disease', 'dental caries', 'serous adenocarcinoma', 'retinopathy', 'adrenal gland neoplasm'], tissue_specific_expression={'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\"small intestine Peyer's patch\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}, is_essential=False, genetic_constraint={'syn': 0.11195000261068344, 'mis': 4.47730016708374, 'lof': 1.0}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.', '*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett\\\\'s esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'frontal lobe\\\\': -1, \\\\'endothelial cell of umbilical vein (resting)\\\\': 2, \\\\'zone of skin\\\\': 0, \\\\'regulatory T cell\\\\': 1, \\\\'pancreas\\\\': -1, \\\\'suprapubic skin\\\\': -1, \\\\'temporal lobe\\\\': -1, \\\\'parathyroid gland\\\\': -1, \\\\'spleen\\\\': -1, \\\\'Brodmann (1909) area 9\\\\': -1, \\\\'breast\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': -1, \\\\'alternatively activated macrophage\\\\': 2, \\\\'segmented neutrophil of bone marrow\\\\': 4, \\\\'placenta\\\\': -1, \\\\'mature eosinophil\\\\': 1, \\\\'granulocyte monocyte progenitor cell\\\\': 0, \\\\'gall bladder\\\\': -1, \\\\'esophagus muscularis mucosa\\\\': -1, \\\\'seminal vesicle\\\\': -1, \\\\'endocervix\\\\': -1, \\\\'lower leg skin\\\\': -1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 2, \\\\'CD8-positive, alpha-beta T cell\\\\': 3, \\\\'cerebral cortex\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': 4, \\\\'hippocampus proper\\\\': -1, \\\\'uterus\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': 3, \\\\'tonsil\\\\': -1, \\\\'esophagus\\\\': 0, \\\\'transverse colon\\\\': -1, \\\\'pituitary gland\\\\': -1, \\\\'coronary artery\\\\': -1, \\\\'memory B cell\\\\': 0, \\\\'sigmoid colon\\\\': -1, \\\\'cerebellum\\\\': -1, \\\\'erythroblast\\\\': 2, \\\\'prefrontal cortex\\\\': -1, \\\\'nucleus accumbens\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'vermiform appendix\\\\': -1, \\\\'greater omentum\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': 1, \\\\'leukocyte\\\\': 2, \\\\'adrenal gland\\\\': -1, \\\\'atrium auricular region\\\\': -1, \\\\'thyroid gland\\\\': 0, \\\\'tibial artery\\\\': -1, \\\\'common lymphoid progenitor\\\\': 3, \\\\'urinary bladder\\\\': -1, \\\\'duodenum\\\\': -1, \\\\'heart muscle\\\\': -1, \\\\'small intestine\\\\': -1, \\\\'neutrophilic metamyelocyte\\\\': 3, \\\\'minor salivary gland\\\\': -1, \\\\'rectum\\\\': 0, \\\\'ovary\\\\': -1, \\\\'substantia nigra\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': -1, \\\\'class switched memory B cell\\\\': 1, \\\\'fallopian tube\\\\': -1, \\\\'esophagus mucosa\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 0, \\\\'bronchus\\\\': -1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": -1, \\\\'kidney\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'macrophage\\\\': 1, \\\\'aorta\\\\': -1, \\\\'skeletal muscle tissue\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': 4, \\\\'caudate-putamen\\\\': -1, \\\\'liver\\\\': -1, \\\\'cytotoxic CD56-dim natural killer cell\\\\': 2, \\\\'mature neutrophil\\\\': 2, \\\\'hypothalamus\\\\': -1, \\\\'transformed skin fibroblast\\\\': -1, \\\\'bone marrow\\\\': -1, \\\\'inflammatory macrophage\\\\': 0, \\\\'cortex of kidney\\\\': -1, \\\\'lung\\\\': -1, \\\\'epididymis\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'saliva-secreting gland\\\\': -1, \\\\'nasopharynx\\\\': -1, \\\\'colon\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'stomach\\\\': -1, \\\\'testis\\\\': -1, \\\\'smooth muscle tissue\\\\': 0, \\\\'putamen\\\\': -1, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 5, \\\\'C1 segment of cervical spinal cord\\\\': 0, \\\\'blood\\\\': -1, \\\\'hematopoietic stem cell\\\\': 1, \\\\'caudate nucleus\\\\': -1, \\\\'amygdala\\\\': -1, \\\\'brain\\\\': 0, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'ectocervix\\\\': -1, \\\\'prostate gland\\\\': -1, \\\\'conventional dendritic cell\\\\': 4, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'heart left ventricle\\\\': -1, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 0, \\\\'vagina\\\\': -1, \\\\'esophagogastric junction\\\\': -1, \\\\'lymph node\\\\': -1, \\\\'endometrium\\\\': -1, \\\\'heart\\\\': -1, \\\\'oral mucosa\\\\': -1, \\\\'CD8-positive, alpha-beta thymocyte\\\\': 4, \\\\'common myeloid progenitor\\\\': 0, \\\\'tibial nerve\\\\': -1, \\\\'plasma cell\\\\': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets', 'reactome_pathways']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id='P84022', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'], diseases=['Colorectal cancer', 'Loeys-Dietz syndrome 3'], pathways=['Cytokine Signaling in Immune system', 'Interleukin-1 family signaling', 'SMAD2/3 Phosphorylation Motif Mutants in Cancer', 'Developmental Biology', 'Viral Infection Pathways', 'Signaling by TGFBR3', 'Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer', 'Signaling by Interleukins', 'Deubiquitination', 'Signaling by NOTCH', 'TGF-beta receptor signaling activates SMADs', 'Signaling by TGFB family members', 'Loss of Function of TGFBR1 in Cancer', 'RUNX3 regulates CDKN1A transcription', 'SARS-CoV-1 targets host intracellular signalling and regulatory pathways', 'Signaling by TGF-beta Receptor Complex', 'TGFBR1 KD Mutants in Cancer', 'Post-translational protein modification', 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes', 'TGFBR3 expression', 'Disease', 'Generic Transcription Pathway', 'Metabolism of proteins', 'Gene expression (Transcription)', 'Signal Transduction', 'SARS-CoV-1-host interactions', 'FOXO-mediated transcription', 'Infectious disease', 'Gastrulation', 'RNA Polymerase II Transcription', 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription', 'NOTCH4 Intracellular Domain Regulates Transcription', 'FOXO-mediated transcription of cell cycle genes', 'Loss of Function of SMAD2/3 in Cancer', 'SMAD4 MH2 Domain Mutants in Cancer', 'Diseases of signal transduction by growth factor receptors and second messengers', 'SARS-CoV Infections', 'Formation of axial mesoderm', 'SARS-CoV-1 Infection', 'Germ layer formation at gastrulation', 'Signaling by NOTCH4', 'Downregulation of TGF-beta receptor signaling', 'Interleukin-37 signaling', 'Formation of definitive endoderm', 'RUNX3 regulates BCL2L11 (BIM) transcription', 'Ub-specific processing proteases', 'Loss of Function of SMAD4 in Cancer', 'Downregulation of SMAD2/3:SMAD4 transcriptional activity', 'Immune System', 'SMAD2/3 MH2 Domain Mutants in Cancer', 'Transcriptional regulation by RUNX3', 'Signaling by Activin', 'Signaling by TGF-beta Receptor Complex in Cancer', 'Signaling by NODAL'], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['BAG3', 'HIF1A', 'SMAD2', 'SMAD4', 'SMURF1', 'SMURF2', 'SP1'], 'Affinity Capture-MS': ['ARID1A', 'ATG14', 'ATG16L1', 'ATXN2L', 'BUB3', 'C1ORF116', 'CD6', 'CDK11A', 'CHD8', 'CIC', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DCAF4', 'DCAF7', 'DDX3X', 'DDX3Y', 'DDX4', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'DZIP3', 'EPB41L5', 'ERBB2IP', 'EVA1B', 'EZH2', 'FAM83G', 'FURIN', 'HINT3', 'HSPA4', 'IRF7', 'IRS1', 'ITGB4', 'KAT6A', 'KCTD16', 'LACRT', 'LDLRAD4', 'LEMD3', 'LRCH1', 'LSR', 'MAP2K3', 'MAPK1', 'MED16', 'MED4', 'NCOA3', 'NF2', 'OPA1', 'OTUB1', 'OTUD1', 'PABPC1', 'PARK2', 'PJA1', 'PLEKHA4', 'PPIE', 'PRNP', 'PSPC1', 'PTPN6', 'RAB11FIP5', 'RPL3', 'RPL4', 'RPSAP15', 'SIK3', 'SLC25A12', 'SLC9A3R2', 'SMAD1', 'SMAD2', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMURF2', 'SNW1', 'SQRDL', 'SUZ12', 'TAF1', 'TAF2', 'TCP1', 'TGFB1', 'TMEM192', 'TRIM33', 'TRIM67', 'TRIP4', 'U2AF2', 'UGT1A10', 'USP33', 'USP7', 'VAV2', 'WWP2', 'YTHDF2', 'YY1', 'ZFP69B', 'ZFYVE9', 'ZRANB1'], 'Affinity Capture-RNA': ['DDX58', 'TRIM25'], 'Affinity Capture-Western': ['ACTB', 'ACVR1B', 'AKT1', 'ANAPC10', 'AR', 'ATF2', 'ATF3', 'BACH1', 'BRCA1', 'BRCA2', 'BTRC', 'CBL', 'CDC16', 'CDC25A', 'CDC27', 'CDKN1A', 'CEBPD', 'CHRD', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CSNK1G2', 'CTCF', 'CTNNB1', 'CUL1', 'DAB2', 'DACH1', 'DEDD', 'DOCK9', 'E2F4', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXL2', 'FOXM1', 'FOXO1', 'FOXO3', 'FOXO4', 'GRIP1', 'GSK3B', 'HDAC4', 'HDAC5', 'HGS', 'HIF1A', 'HNF4A', 'HYAL2', 'ID1', 'IRF7', 'JUN', 'KAT2A', 'KAT2B', 'KAT6A', 'KDM5C', 'KDM6B', 'KLF5', 'KPNB1', 'LEF1', 'MAFK', 'MECOM', 'MED15', 'MED24', 'MED6', 'MEN1', 'METTL14', 'METTL3', 'MKL1', 'MYC', 'MYD88', 'MYOCD', 'NCOA1', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIC', 'NFYC', 'NOTCH1', 'NOTCH4', 'NR3C1', 'NR4A1', 'NUP214', 'OTUB1', 'OTUD1', 'OVOL2', 'PAX6', 'PCK2', 'PDLIM5', 'PIAS3', 'PIAS4', 'PIN1', 'PITX1', 'PITX2', 'PML', 'PPARG', 'PPP1R12C', 'PRDM16', 'PRTN3', 'RARA', 'RBBP5', 'RBL1', 'RBX1', 'RELB', 'RGCC', 'RNF111', 'RNF31', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SETD2', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD7', 'SMARCA4', 'SMARCC2', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'SQSTM1', 'SREBF2', 'SRY', 'STRAP', 'STUB1', 'SUV39H1', 'TCF12', 'TGFB1I1', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TGIF2', 'TOB1', 'TP53', 'TRIB3', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'TSC22D4', 'UCHL1', 'UCHL5', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWOX', 'WWP1', 'WWP2', 'YAP1', 'ZC3H12A', 'ZEB1', 'ZEB2', 'ZFYVE9', 'ZMIZ1'], 'Biochemical Activity': ['CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'CSNK1G2', 'MAPK1', 'NEDD4', 'NEDD4L', 'OTUB1', 'TGFBR1', 'USP15', 'USP7', 'WWP2'], 'Co-crystal Structure': ['SMAD3', 'SMAD4', 'ZFYVE9'], 'Co-fractionation': ['ALKBH2', 'ANAPC10', 'APP', 'ARID1B', 'CDH1', 'CREBBP', 'CTCF', 'CTNNB1', 'CUL1', 'DDR1', 'FOXO3', 'HDAC1', 'HMGA2', 'IGF1R', 'ITGB1', 'JUND', 'MTA2', 'NAA15', 'NT5DC3', 'PARP1', 'PRKDC', 'RBM14', 'RBX1', 'RELA', 'RIPK1', 'RNMT', 'SIN3A', 'SKP1', 'SMAD2', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SP1', 'SUB1', 'TRIM33', 'XRCC5', 'XRCC6', 'ZFHX3', 'ZFYVE9'], 'Co-localization': ['AKT1', 'BMP7', 'CAMK2G', 'CDK2', 'CDK4', 'EPAS1', 'ETS1', 'FOXO3', 'HIF1A', 'IRF7', 'MAP3K7', 'MAPK8', 'MAX', 'TP53', 'TRIM62'], 'Cross-Linking-MS (XL-MS)': ['RPL10A'], 'FRET': ['SMAD4', 'STUB1'], 'PCA': ['SMAD4', 'SMAD7'], 'Phenotypic Enhancement': ['HIF1A', 'SMAD2', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['JAK1'], 'Protein-RNA': ['LINC00941'], 'Protein-peptide': ['CREBBP', 'FOXH1', 'ITCH', 'LEF1', 'NEDD4', 'PIN1'], 'Proximity Label-MS': ['NFIA'], 'Reconstituted Complex': ['ANAPC10', 'APP', 'AR', 'ATF2', 'ATF3', 'BPTF', 'BRCA1', 'BRCA2', 'CEBPA', 'CEBPB', 'CEBPD', 'CITED2', 'CREBBP', 'CTCF', 'DAB2', 'DDX5', 'DEDD', 'DNMT3L', 'DVL1', 'E2F4', 'EID2', 'EIF4B', 'EP300', 'ERBB2IP', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXM1', 'GSK3B', 'HDAC1', 'HDAC4', 'HDAC5', 'HIF1A', 'HIPK2', 'HNF4A', 'HYAL2', 'IRF7', 'ITCH', 'JUN', 'JUNB', 'JUND', 'KAT2B', 'KAT6A', 'KPNB1', 'LCK', 'LEF1', 'LEMD3', 'MAX', 'MDM4', 'MECOM', 'MYC', 'MYOCD', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIA', 'NOTCH1', 'NR3C1', 'NUP153', 'NUP214', 'PARD3', 'PIAS2', 'PIAS3', 'PIAS4', 'PIK3CA', 'PIN1', 'RBL1', 'RUNX2', 'S100A4', 'SH2D2A', 'SIN3A', 'SKI', 'SKIL', 'SMAD3', 'SMAD4', 'SMURF2', 'SNW1', 'SP1', 'STUB1', 'TFE3', 'TGFB1I1', 'TGFBR1', 'TGIF1', 'TP53', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'UCHL5', 'USP15', 'VDR', 'WWOX', 'XPO6', 'YY1', 'ZFYVE9', 'ZMIZ1'], 'Two-hybrid': ['AATF', 'AES', 'ANK3', 'APMAP', 'APOB', 'AR', 'ATF2', 'BLZF1', 'C10ORF54', 'C14ORF105', 'CCDC33', 'CDC25A', 'CFDP1', 'CFH', 'CFLAR', 'CHRD', 'CORO1A', 'CPSF7', 'CPTP', 'CREBBP', 'CRX', 'CSH2', 'CXXC5', 'CYP11A1', 'DEDD', 'DNAJB4', 'DNAJB5', 'EBI3', 'EP300', 'EPAS1', 'FAM90A1', 'FBLN1', 'FLI1', 'FLNA', 'FOS', 'FOXH1', 'GGA1', 'GIT2', 'GMEB1', 'HDAC1', 'HEY1', 'HEYL', 'HIF1A', 'HIVEP1', 'HNRNPK', 'HOXC11', 'HP', 'ISL1', 'JUN', 'JUNB', 'KANSL1', 'KDM2A', 'KMT2B', 'LBP', 'MCM3AP', 'MEOX2', 'MTF2', 'MYC', 'MYD88', 'NCOA6', 'NEDD4', 'NEDD9', 'NR4A1', 'PAPPA', 'PARP4', 'PCDH1', 'PCK2', 'PHC2', 'PIAS4', 'PIN1', 'PLAG1', 'PLAGL1', 'PLG', 'PPP1R12C', 'PPP2R1A', 'PRDM4', 'PROX1', 'PSMB1', 'PSMD11', 'RANBP9', 'RBPMS', 'RBX1', 'RCVRN', 'RELA', 'RIOK2', 'RNF31', 'RPA1', 'RPLP0', 'SAP130', 'SBK3', 'SERTAD1', 'SETD2', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMURF1', 'SMURF2', 'SNRNP70', 'SNW1', 'SP1', 'SQSTM1', 'SS18L1', 'ST6GALNAC2', 'SVEP1', 'TANK', 'TDP2', 'TEKT4', 'TF', 'TGM2', 'TLR4', 'TMED1', 'TSC22D4', 'UBQLN4', 'USP7', 'VDR', 'WWP1', 'WWP2', 'XRCC6', 'ZBTB16', 'ZBTB3', 'ZC3H12A', 'ZCCHC14', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF329', 'ZNF774', 'ZNF83']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF6', 'ARHGEF7', 'CLASRP', 'FBXO3', 'GSC', 'MAP2K3', 'PPP2R2D', 'RAB38', 'RASD2', 'RGS3', 'RRAS2', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'WEE1', 'WWP2'], 'Affinity Capture-MS': ['ATG16L1', 'E6', 'NSP6', 'OTUB1', 'SMAD3'], 'Affinity Capture-Western': ['AXIN1', 'COL1A1', 'COL3A1', 'COL5A1', 'DDX5', 'DOK1', 'E6', 'E7', 'EP300', 'GATA4', 'GNB2L1', 'HCVGP1', 'HDAC4', 'KLF4', 'MED15', 'MELK', 'N', 'RNF111', 'SKI', 'SMAD3', 'SMAD3A', 'SMAD4', 'TGFB1I1', 'TOB1', 'TOB1A', 'TOB1B', 'VDR', 'ZEB1'], 'Co-localization': ['E7', 'N'], 'PCA': ['E6'], 'Phenotypic Enhancement': ['SMAD3A'], 'Phenotypic Suppression': ['SMAD3A'], 'Proximity Label-MS': ['M'], 'Reconstituted Complex': ['E6', 'E7', 'GATA4', 'N', 'SIN3A', 'SMAD3', 'SOX9', 'YAP1', 'ZFP128'], 'Synthetic Growth Defect': ['MMP9'], 'Two-hybrid': ['DVL1', 'E6', 'ERBB2IP', 'FOXH1', 'GATA4', 'HCVGP1', 'JUN', 'MAGI2', 'PARD3', 'SMAD3', 'ZEB2']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Large for gestational age', 'Alopecia', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Right ventricular hypertrophy', 'Myocardial fibrosis', 'Hallux valgus', 'Increased total eosinophil count', 'Acute kidney injury', 'Renal artery stenosis', 'Hypoglycemia', 'Glucose intolerance', 'Abnormal thrombosis', 'Rectal prolapse', 'Esophageal stricture', 'Pulmonary hypoplasia', 'Asthma', 'Cerebral cortical atrophy', 'Ischemic stroke', 'Aortic root aneurysm', 'Aortic dissection', 'Spontaneous pneumothorax', 'Vascular dilatation', 'Cerebral ischemia', 'Immunodeficiency', 'Systemic lupus erythematosus', 'Oral leukoplakia', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Back pain', 'Muscular dystrophy', 'Hernia of the abdominal wall', 'Cachexia', 'Ascending aortic dissection', 'Venous thrombosis', 'Ascending tubular aorta aneurysm', 'Ureteral obstruction', 'Airway obstruction', 'Pituitary prolactin cell adenoma', 'Premature ovarian insufficiency', 'Intervertebral disk degeneration', 'Lipodystrophy', 'Hamartoma', 'Chordoma', 'Stress urinary incontinence', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Urethral stricture', 'Allergy', 'Renal atrophy', 'Pulmonary bulla', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Hernia', 'Sepsis', 'Skin ulcer', 'Left ventricular dilatation', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'adolescent idiopathic scoliosis', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'gamma chain deficiency', 'seborrheic keratosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'smoking initiation', 'Staphylococcus aureus infection', 'rheumatic disease', 'lupus nephritis', 'pulse pressure measurement', 'neurodegenerative disease', 'retinal detachment', 'Autoimmune Hepatitis', 'non-high density lipoprotein cholesterol measurement', 'brain disease', 'aortic disease', 'neonatal abstinence syndrome', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'non-Hodgkins lymphoma', 'breast ductal adenocarcinoma', 'systolic blood pressure', 'diastolic blood pressure', 'pulmonary artery enlargement', 'laryngeal squamous cell carcinoma', 'cystadenocarcinoma', 'ovarian mucinous adenocarcinoma', 'smoking status measurement', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'cerebral amyloid angiopathy', 'autoimmune thyroid disease', 'stricture', 'head and neck malignant neoplasia', 'urgency urinary incontinence', 'fibrosis', 'diastolic blood pressure change measurement', 'drug use measurement', 'allergic conjunctivitis', 'aortic valve insufficiency', 'Balkan nephropathy', 'bronchiolitis obliterans', 'congenital rubella', 'coronavirus infectious disease', 'echinococcosis', 'endodermal sinus tumor', 'Gerstmann syndrome', 'Guillain-Barre syndrome', 'influenza', 'intestinal cancer', 'legionellosis', 'lymphatic system disease', 'male reproductive organ cancer', 'aneurysm-osteoarthritis syndrome', 'autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome', 'hyperuricemic nephropathy, familial juvenile type 3', 'graft versus host disease', 'autoimmune lymphoproliferative syndrome type 4', 'combined immunodeficiency due to LRBA deficiency', 'adenine phosphoribosyltransferase deficiency', 'karyomegalic interstitial nephritis', 'dyskeratosis congenita, autosomal recessive 5', 'TCR-alpha-beta-positive T-cell deficiency', 'severe combined immunodeficiency due to IKK2 deficiency', 'immunodeficiency 18', 'immunodeficiency 23', 'severe combined immunodeficiency due to CTPS1 deficiency', 'severe neurodegenerative syndrome with lipodystrophy', 'periodic fever-infantile enterocolitis-autoinflammatory syndrome', 'immunodeficiency 37', 'chronic atrial and intestinal dysrhythmia', 'DOCK2 deficiency', 'DDX41-related hematologic malignancy predisposition syndrome', 'fibrochondrogenesis 2', 'C3 glomerulonephritis', 'agammaglobulinemia 7, autosomal recessive', 'autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency', 'infantile-onset periodic fever-panniculitis-dermatosis syndrome', 'lung disease, immunodeficiency, and chromosome breakage syndrome;', 'neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade', 'chronic diarrhea due to glucoamylase deficiency', 'Bardet-Biedl syndrome', 'familial pancreatic carcinoma', 'nasopharyngeal carcinoma', 'craniosynostosis', 'keratoconus', 'common variable immunodeficiency', 'hyperplastic polyposis syndrome', 'dentin dysplasia', 'T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'qualitative or quantitative defects of dysferlin', 'holoprosencephaly', 'attenuated familial adenomatous polyposis', 'isolated agammaglobulinemia', 'pachyonychia congenita', 'familial hyperaldosteronism', 'hypohidrotic ectodermal dysplasia', 'primary ciliary dyskinesia', 'APC-related attenuated familial adenomatous polyposis', 'meningioma', 'multiple epiphyseal dysplasia', 'hemangioblastoma', 'Moyamoya disease', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'IgG4-related disease', 'juvenile polyposis syndrome', 'pituitary tumor', 'ameloblastoma', 'exstrophy-epispadias complex', 'autoimmune lymphoproliferative syndrome', 'syringomyelia', 'selective IgM deficiency', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', 'congestive heart failure', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'embryonal rhabdomyosarcoma', 'emphysema', 'epilepsy', 'fetal growth restriction', 'ganglioneuroma', 'gastric adenocarcinoma', 'esophageal adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'glioblastoma multiforme', 'hypertension', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'tuberculosis', 'glioblastoma', 'chronic granulomatous disease', 'liver mesenchymal hamartoma', 'activated PI3K-delta syndrome', 'carcinoma of liver and intrahepatic biliary tract', 'cutaneous polyarteritis nodosa', 'hereditary nonpolyposis colon cancer', 'Polymerase proofreading-related adenomatous polyposis', 'Zika virus infectious disease', 'regressive spondylometaphyseal dysplasia', 'Jeune syndrome', 'Li-Fraumeni syndrome', 'posterior cortical atrophy', '22q11.2 deletion syndrome', 'Loeys-Dietz syndrome', 'congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization', 'intrahepatic cholestasis', 'bronchopulmonary dysplasia', 'Hirschsprung disease', 'mucinous adenocarcinoma of the appendix', 'Lhermitte-Duclos disease', 'sarcoidosis', 'peeling skin syndrome', 'Fanconi anemia', 'dysspondyloenchondromatosis', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'acute liver failure', 'discoid lupus erythematosus', 'familial thoracic aortic aneurysm and aortic dissection', 'renal hypoplasia', 'renal dysplasia', 'spondyloepiphyseal dysplasia tarda', 'ulnar hemimelia', 'radial hemimelia', 'growth hormone-producing pituitary gland neoplasm', 'encephalitis', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'autosomal dominant cerebellar ataxia', 'precursor B-cell acute lymphoblastic leukemia', 'chronic graft versus host disease', 'superficial spreading melanoma', 'renal pelvis/ureter urothelial carcinoma', 'tubulointerstitial kidney disease, autosomal dominant, 2', 'lung neoplasm', 'intestinal neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'neoplasm of esophagus', 'tumor of parathyroid gland', 'polyp of colon', 'low grade glioma', 'coronary atherosclerosis', 'gram-negative bacterial infections', 'sexually transmitted disease', 'radiculitis', 'viral myocarditis', 'lip and oral cavity carcinoma', 'immunodeficiency 14b, autosomal recessive', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'respiratory tract infectious disorder', 'chondrogenic neoplasm', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'synucleinopathy', 'pulmonary sarcoidosis', 'gonorrhea', 'chronic lymphocytic leukemia', 'neoplasm of mature B-cells', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'metastatic prostate cancer', 'T-cell acute lymphoblastic leukemia', 'unspecified peripheral T-cell lymphoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'oral squamous cell carcinoma', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'adenocarcinoma', 'adenoma', 'adenosquamous lung carcinoma', 'adrenal gland pheochromocytoma', 'alveolar rhabdomyosarcoma', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', 'benign prostatic hyperplasia', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'Burkitts lymphoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'chondrosarcoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'chronic pancreatitis', 'clear cell renal carcinoma', 'endometrial carcinoma', 'renal fibrosis', 'Adenomyosis', 'immunoproliferative small intestinal disease', 'Posterior Leukoencephalopathy Syndrome', 'amyloidosis', 'neuroendocrine neoplasm', 'Spinal cord injury', 'B-cell non-Hodgkins lymphoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'intrahepatic cholangiocarcinoma', 'pharyngeal squamous cell carcinoma', 'connective tissue disease', 'pneumonitis', 'Carcinoma, Lewis Lung', 'soft tissue sarcoma', 'adult onset asthma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'renal hypertension', 'glomerular disease', 'nephritis', 'positive regulation of ovulation', 'Neurogenic bladder', 'Inguinal hernia', 'Abnormality of the urinary system', 'Renal insufficiency', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Nephrocalcinosis', 'Uterine leiomyoma', 'Cleft palate', 'Retrognathia', 'Strabismus', 'Cataract', 'Proptosis', 'Myopia', 'Pectus excavatum', 'Infertility', 'Hematuria', 'Diabetes mellitus', 'Hyperinsulinemia', 'Insulin resistance', 'Abnormality of the skeletal system', 'Osteopenia', 'Osteoporosis', 'Jaundice', 'Eczematoid dermatitis', 'Global developmental delay', 'Stroke', 'Encephalopathy', 'Parkinsonism', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Cholestasis', 'Hepatic steatosis', 'Obesity', 'ornithine carbamoyltransferase deficiency', 'pseudomyxoma peritonei', 'silicosis', 'spinal stenosis', 'BMI-adjusted waist-hip ratio', 'BMI-adjusted waist circumference', 'body fat percentage', 'balding measurement', 'liver dysplastic nodule', 'wellbeing measurement', 'insomnia measurement', 'eosinophil percentage of leukocytes', 'eosinophil percentage of granulocytes', 'BMI-adjusted hip circumference', 'calf circumference measurement', 'chronic hepatitis', 'dysplasia', 'interstitial cystitis', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'oral lichen planus', 'rhinitis', 'small cell carcinoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'Hepatobiliary Neoplasm', 'acute myocardial infarction', 'peritonitis', 'pemphigus foliaceus', 'paraneoplastic pemphigus', 'cystic kidney disease', 'ovarian dysfunction', 'Arteritis', 'Polyarteritis Nodosa', 'arteriosclerosis', 'idiopathic dilated cardiomyopathy', 'hyperuricemia', 'female reproductive endometrioid cancer', 'skin carcinoma', 'heel bone mineral density', 'marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections', 'central nervous system disease', 'sum of eosinophil and basophil counts', 'lower respiratory tract disease', 'pulmonary fibrosis', 'infarction', 'corneal disease', 'vertebral joint disease', 'aortic valve disease', 'cervical disc degenerative disorder', 'hemorrhoid', 'mitral valve disease', 'feeling nervous measurement', 'stomach disease', 'myocarditis', 'aneurysm', 'laryngeal disease', 'musculoskeletal system disease', 'Gallbladder Adenocarcinoma', 'Gallbladder Adenoma', 'Gastric Neuroendocrine Tumor G1', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Mast Cell Sarcoma', 'Nasal Cavity Polyp', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Ovarian Granulosa Cell Tumor', 'Peritoneal Multicystic Mesothelioma', 'Pituitary Gland Adenoma', 'Placental Choriocarcinoma', 'Pleural Epithelioid Mesothelioma', 'Poorly Differentiated Thyroid Gland Carcinoma', 'Rectal Tubular Adenoma', 'Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions', 'Signet Ring Cell Gastric Adenocarcinoma', 'small intestinal adenocarcinoma', 'Spinal Chordoma', 'Testicular Embryonal Carcinoma', 'Thyroid Gland Oncocytic Follicular Carcinoma', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vaginal Melanoma', 'hamartoma', 'acute respiratory distress syndrome', 'rectum cancer', 'acanthosis nigricans', 'cholesteatoma', 'Primary Pulmonary Diffuse Large B-Cell Lymphoma', 'developmental dysplasia of the hip', 'sarcopenia', 'mucous membrane pemphigoid', 'osteoarthritis, hip', 'osteoarthritis, spine', 'adrenal cortex carcinoma', 'adrenal gland hyperfunction', 'alcoholic cardiomyopathy', 'aortitis', 'atrial heart septal defect', 'causalgia', 'coronary aneurysm', 'diastolic heart failure', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'joint disease', 'lipoid nephrosis', 'mouth disease', 'multiple system atrophy', 'myeloid sarcoma', 'ocular hypertension', 'parathyroid adenoma', 'proliferative vitreoretinopathy', 'pulmonary edema', 'pulpitis', 'Raynaud disease', 'renovascular hypertension', 'rheumatic heart disease', 'Schnitzler syndrome', 'thromboangiitis obliterans', 'ulcerative proctosigmoiditis', 'uremia', 'non-alcoholic steatohepatitis', 'rotator cuff tear', 'Anemia, Hemolytic, Autoimmune', 'Cardiac Tamponade', 'End Stage Liver Disease', 'Endometritis', 'Escherichia coli Infections', 'Genital neoplasm, female', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Lentivirus Infections', 'Myocardial Ischemia', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Tularemia', 'diabetic cardiomyopathy', 'endothelial dysfunction', 'gliosarcoma', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'metastatic colorectal cancer', 'enterocolitis', 'primary biliary cirrhosis', 'abortion', 'psoriasis vulgaris', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'primary hyperoxaluria type 2', 'hyperimmunoglobulinemia D with periodic fever', 'autosomal recessive polycystic kidney disease', 'Senior-Loken syndrome 1', 'reticular dysgenesis', 'schneckenbecken dysplasia', 'combined immunodeficiency due to ZAP70 deficiency', 'familial isolated congenital asplenia', 'brachyolmia type 1, Hobaek type', 'brachyolmia type 1, toledo type', 'spondyloperipheral dysplasia', 'thoracomelic dysplasia', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'Wilson disease', 'X-linked spondyloepimetaphyseal dysplasia', 'hypoxanthine guanine phosphoribosyltransferase partial deficiency', 'Bruton-type agammaglobulinemia', 'X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia', 'combined immunodeficiency due to moesin deficiency', 'Wiskott-Aldrich syndrome', 'Aarskog-Scott syndrome, X-linked', 'hyper-IgM syndrome type 1', 'Melnick-Needles syndrome', 'Bartsocas-Papas syndrome 1', 'pulmonary venoocclusive disease', 'spondyloepimetaphyseal dysplasia, Irapa type', 'SHOX-related short stature', 'immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'spondyloepiphyseal dysplasia tarda, X-linked', 'T-B+ severe combined immunodeficiency due to JAK3 deficiency', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'skeletal dysplasia-epilepsy-short stature syndrome', 'hereditary mixed polyposis syndrome', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive', 'Ehlers-Danlos syndrome, musculocontractural type', 'spondyloepimetaphyseal dysplasia, Missouri type', 'axial spondylometaphyseal dysplasia', 'severe combined immunodeficiency due to DCLRE1C deficiency', 'spondyloepimetaphyseal dysplasia, Shohat type', 'myotonic dystrophy type 2', 'radioulnar synostosis-microcephaly-scoliosis syndrome', 'spondyloepimetaphyseal dysplasia with multiple dislocations', 'Omenn syndrome', 'xanthinuria type II', 'autoimmune lymphoproliferative syndrome type 2A', 'nephronophthisis 3', 'pyogenic arthritis-pyoderma gangrenosum-acne syndrome', 'hyper-IgM syndrome type 2', 'immunodeficiency due to CD25 deficiency', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'hyper-IgM syndrome type 3', 'multiple epiphyseal dysplasia type 5', 'anauxetic dysplasia', 'autoimmune lymphoproliferative syndrome type 2B', 'Smith-McCort dysplasia 1', 'granular corneal dystrophy type II', 'acrocapitofemoral dysplasia', 'endometrial cancer', 'hyper-IgM syndrome type 5', 'hyper-IgM syndrome type 4', 'neutrophil immunodeficiency syndrome', 'familial adenomatous polyposis 2', 'spondyloepimetaphyseal dysplasia, matrilin-3 type', 'familial avascular necrosis of femoral head', 'immunodeficiency 104', 'spondylometaphyseal dysplasia, A4 type', 'epidermolysis bullosa simplex 7, with nephropathy and deafness', 'permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome', 'mesoaxial synostotic syndactyly with phalangeal reduction', 'hyperinsulinemic hypoglycemia, familial, 4', 'Mungan syndrome', 'familial cold autoinflammatory syndrome 2', 'aortic aneurysm, familial thoracic 6', 'hypouricemia, renal, 2', 'dopa-responsive dystonia due to sepiapterin reductase deficiency', 'combined immunodeficiency due to STIM1 deficiency', 'atypical hemolytic-uremic syndrome with MCP/CD46 anomaly', 'atypical hemolytic-uremic syndrome with I factor anomaly', 'atypical hemolytic-uremic syndrome with B factor anomaly', 'atypical hemolytic-uremic syndrome with C3 anomaly', 'atypical hemolytic-uremic syndrome with thrombomodulin anomaly', 'lymphoproliferative syndrome 1', 'purine nucleoside phosphorylase deficiency', 'spondylo-megaepiphyseal-metaphyseal dysplasia', 'brachydactylous dwarfism, Mseleni type', 'spondyloepimetaphyseal dysplasia, Handigodu type', 'hemolytic anemia due to glucophosphate isomerase deficiency', 'alpha 1-antitrypsin deficiency', 'occult macular dystrophy', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'polyp', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'renal cell carcinoma', 'respiratory system disease', 'sarcoma', 'severe acute respiratory syndrome', 'Sjogren syndrome', 'skin disease', 'small cell lung carcinoma', 'rheumatoid arthritis', 'spindle cell tumor', 'spondyloarthropathy', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'systemic scleroderma', 'ulcerative colitis', 'uterine fibroid', 'melanoma', 'malignant peripheral nerve sheath tumor', 'viral disease', 'HIV infection', 'AIDS', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'temporal lobe epilepsy', 'myositis', 'leprosy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'Down syndrome', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'lung carcinoma', 'ovarian carcinoma', 'post-traumatic stress disorder', 'pulmonary arterial hypertension', 'synovial sarcoma', 'autosomal dominant polycystic liver disease', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'small intestinal neuroendocrine tumor G1', 'breast benign neoplasm', 'central nervous system primitive neuroectodermal neoplasm', 'vertebral column disorder', 'cerebral cavernous malformation', 'interstitial emphysema', 'gastric cancer', 'essential hypertension', 'hypertensive heart disease', 'familial hyperlipidemia', 'impaired renal function disease', 'myopia', 'nephrocalcinosis', 'leiomyoma', 'prolapse of female genital organ', 'brain cancer', 'nontoxic goiter', 'pure red-cell aplasia', 'crescentic glomerulonephritis', 'tuberous sclerosis', 'depressive disorder', 'ventricular septal defect', 'pneumothorax', 'Richter syndrome', 'thyroid cancer', 'giant cell tumor', 'spondylosis', 'papilloma', 'kidney cancer', 'dermatitis', 'prostatic adenoma', 'lobular neoplasia', 'gingival overgrowth', 'papillary adenocarcinoma', 'digestive system cancer', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratocarcinoma', 'teratoma', 'bone inflammation disease', 'small cell osteogenic sarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'anal canal adenocarcinoma', 'skin cancer', 'cerebellar neoplasm', 'cervical cancer', 'breast angiosarcoma', 'bile duct adenocarcinoma', 'thoracic cancer', 'colonic disorder', 'functioning pituitary gland adenoma', 'anal canal squamous cell carcinoma', 'pancreatic intraductal papillary-mucinous neoplasm', 'muscular atrophy', 'female breast carcinoma', 'retinal degeneration', 'MHC class II deficiency 4', 'immunodeficiency 122', 'inflammation', 'circulating fibrinogen levels', 'glomerular filtration rate', 'fat pad mass', 'hip circumference', 'bone tissue density', 'von Willebrand factor quality', 'waist circumference', 'age of onset of asthma', 'level of serum globulin type protein', 'red blood cell density', 'serum alanine aminotransferase amount', 'heart rate', 'age of onset of allergic disease', 'brain volume', 'serum albumin amount', 'serum creatinine amount', 'body height', 'cyst', 'X-linked hyper-IgM syndrome', 'Brachydactyly - elbow wrist dysplasia', 'Chronic mucocutaneous candidosis', 'Desbuquois syndrome', 'Chédiak-Higashi syndrome', 'Recurrent infection due to specific granule deficiency', 'Immunodeficiency syndrome with autoimmunity', 'Metaphyseal chondrodysplasia, Schmid type', 'Åland Islands eye disease', 'Ichthyosis - intellectual disability - dwarfism - renal impairment', 'Autosomal recessive early-onset inflammatory bowel disease', 'X-linked lymphoproliferative disease', 'Metaphyseal dysostosis - intellectual disability - conductive deafness', 'CHST3-related skeletal dysplasia', 'Cyclic neutropenia', 'Severe combined immunodeficiency due to adenosine deaminase deficiency', 'Aneurysm - osteoarthritis syndrome', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Multiple osteochondromas', 'Recurrent infections-myelofibrosis-nephromegaly syndrome', 'Acromesomelic dysplasia, Maroteaux type', 'Hyperlipoproteinemia type 1', 'X-linked agammaglobulinemia', 'Familial hemophagocytic lymphohistiocytosis', 'Immunodeficiency by defective expression of HLA class 2', 'Pyogenic arthritis - pyoderma gangrenosum - acne', 'Familial adenomatous polyposis', 'Thymic aplasia', 'Other metabolic disease', 'Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification', 'Hypohidrotic ectodermal dysplasia with immunodeficiency', 'Leukocyte adhesion deficiency type III', 'hematocrit', 'C-reactive protein measurement', 'glucose measurement', 'hemoglobin measurement', 'bone quantitative ultrasound measurement', 'triglyceride measurement', 'alkaline phosphatase measurement', 'creatine kinase measurement', 'cryptorchidism', 'total cholesterol measurement', 'gestational diabetes', 'low density lipoprotein cholesterol measurement', 'lymphocyte count', 'acute lung injury', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'cystatin C measurement', 'factor VII measurement', 'IGF-1 measurement', 'factor VIII measurement', 'white matter integrity', 'hip geometry', 'factor XI measurement', 'intraocular pressure measurement', 'sex hormone-binding globulin measurement', 'age at menarche', 'pelvic organ prolapse', 'FEV/FVC ratio', 'prion disease', 'aspartate aminotransferase measurement', 'protein measurement', 'neutrophil count', 'eosinophil count', 'lymph node metastatic carcinoma', 'appendicular lean mass', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'autoimmune disease', 'congenital heart disease', 'central corneal thickness', 'cholangiocarcinoma', 'reading', 'anxiety', 'primitive neuroectodermal tumor', 'aortic valve calcification', 'non-small cell lung adenocarcinoma', 'axial length measurement', 'contact dermatitis', 'vein disorder', 'in situ carcinoma', 'inborn disorder of amino acid metabolism', 'allergic asthma', 'fatty liver disease', 'alopecia', 'hypoplastic left heart syndrome', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'upper respiratory tract disorder', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'Parkinson disease', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'allergic disease', 'multiple sclerosis', 'skin basal cell carcinoma', 'childhood onset asthma', 'colorectal cancer', 'Lynch syndrome', 'Wilms tumor', 'prune belly syndrome', 'Adams-Oliver syndrome', 'Acropectorovertebral dysplasia', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency', 'Tietz syndrome', 'autosomal dominant Alport syndrome', 'Townes-Brocks syndrome', 'atelosteogenesis type III', 'Osebold-Remondini syndrome', 'brachydactyly type C', 'autosomal dominant brachyolmia', 'Gordon syndrome', 'breast cancer', 'chondrocalcinosis 2', 'congenital contractural arachnodactyly', 'fleck corneal dystrophy', 'Duane retraction syndrome', 'Leri-Weill dyschondrosteosis', 'Beckwith-Wiedemann syndrome', 'esophageal cancer', 'autoinflammatory syndrome, familial, X-linked, Behcet-like 2', 'immunodeficiency 98 with autoinflammation, X-linked', 'metastatic malignant neoplasm', 'granulomatous disease, chronic, autosomal recessive, 5', 'hyper-IgE recurrent infection syndrome 5, autosomal recessive', 'immunodeficiency 81', 'immunodeficiency 82 with systemic inflammation', 'inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive', 'immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias', 'immunodeficiency 75', 'immunodeficiency 76', 'nephrotic syndrome 16', 'immunodeficiency 69', 'immunodeficiency 78 with autoimmunity and developmental delay', 'immunodeficiency 70', 'immunodeficiency 72 with autoinflammation', 'immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia', 'autoinflammation, immune dysregulation, and eosinophilia', 'severe combined immunodeficiency due to CD70 deficiency', 'myofibroblastoma', 'invasive carcinoma', 'adenoviridae infectious disease', 'brain injury', 'nosocomial infection', 'enteritis', 'ulcer disease', 'radiation pneumonitis', 'familial adenomatous polyposis 4', 'severe combined immunodeficiency due to LAT deficiency', 'desmoplastic melanoma', 'myelofibrosis', 'salivary duct carcinoma', 'oral cavity carcinoma', 'rectal carcinoma', 'vertebral disorder', 'digestive system melanoma', 'short-rib thoracic dysplasia 17 with or without polydactyly', 'platelet abnormalities with eosinophilia and immune-mediated inflammatory disease', 'COVID-19', 'liver failure', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'spondyloepimetaphyseal dysplasia', 'gastrointestinal defects and immunodeficiency syndrome 1', 'immunodeficiency 105', 'autoinflammatory disease, X-linked', 'autoinflammatory syndrome with immunodeficiency', 'achalasia-alacrima syndrome', 'choroidal neovascularization', 'rhizomelic dysplasia, Ain-Naz type', 'autoinflammatory disease, multisystem, with immune dysregulation, X-linked', 'hyper-IgE syndrome 6, autosomal dominant, with recurrent infections', 'immunodeficiency 113 with autoimmunity and autoinflammation', 'immunodeficiency 117', 'neutropenia, severe congenital, 11, autosomal dominant', 'autoinflammation with episodic fever and immune dysregulation', 'immunodeficiency 119', 'postmenopausal osteoporosis', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'ankylosing spondylitis', 'deep vein thrombosis', 'angina pectoris', 'atherosclerosis', 'necrotizing enterocolitis', 'gastroesophageal reflux disease', 'seasonal allergic rhinitis', 'breast neoplasm', 'left ventricular hypertrophy', 'stomach neoplasm', 'obstructive sleep apnea', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'neuropathy', 'open-angle glaucoma', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Vitiligo', 'hypospadias', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'exfoliation syndrome', 'focal segmental glomerulosclerosis', 'chronic hepatitis B virus infection', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'meningococcal infection', 'membranous glomerulonephritis', 'nephrotic syndrome', 'osteonecrosis', 'bone disease', 'vascular disease', 'peripheral arterial disease', 'sclerosing cholangitis', 'scoliosis', 'brain infarction', 'thoracic aortic aneurysm', 'ventricular fibrillation', 'colonic neoplasm', 'erythrocyte count', 'platelet count', 'vital capacity', 'forced expiratory volume', 'smoking behavior', 'body weight', 'body mass index', 'body fat distribution', 'waist-hip ratio', 'corneal topography', 'neuroimaging measurement', 'metastatic neoplasm', 'wheezing', 'enthesitis-related juvenile idiopathic arthritis', 'Chronic Obstructive Asthma', 'carotid atherosclerosis', 'pulse wave reflection index measurement', 'total hip arthroplasty', 'kidney injury', 'muscle atrophy', 'chromosomal aberration frequency', 'bone metastasis', 'HMG CoA reductase inhibitor use measurement', 'Inhalant adrenergic use measurement', 'Glucocorticoid use measurement', 'low density lipoprotein triglyceride measurement', 'diverticular disease', 'corneal resistance factor', 'citrate measurement', 'cholesteryl ester measurement', 'glucuronate measurement', 'isocitrate measurement', 'atopic asthma', 'coinfection', 'total joint arthroplasty', 'aspartate aminotransferase to alanine aminotransferase ratio', 'nephrotoxicity', 'inflammatory bowel disease, immunodeficiency, and encephalopathy', 'severe malarial anemia', 'total knee arthroplasty', 'palmitate 16:0 measurement', 'sexual dimorphism measurement', 'body surface area', 'serum lipopolysaccharide activity', 'Birt-Hogg-Dube syndrome', '25-hydroxyvitamin D3 measurement', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'granulosa cell tumor', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'pulmonary tuberculosis', 'tongue squamous cell carcinoma', 'nasopharyngeal squamous cell carcinoma', 'Acute Leukemia', 'Ampulla of Vater Carcinoma', 'Appendix Adenocarcinoma', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Cavernous Hemangioma', 'Central Nervous System Lymphoma', 'Cervical Adenosquamous Carcinoma', 'cervical squamous cell carcinoma', 'Colon Dysplasia', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Endometrial Undifferentiated Carcinoma', 'Fibroblastic Neoplasm', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'nonpapillary renal cell carcinoma', 'Pallister-Hall syndrome', 'periodic fever, immunodeficiency, and thrombocytopenia syndrome', 'platyspondylic dysplasia, Torrance type', 'systemic lupus erythematosus', 'Marfan syndrome', 'melorheostosis', 'mesomelic dysplasia, Kantaputra type', 'metatropic dysplasia', 'Mobius syndrome', 'Muir-Torre syndrome', 'Cowden syndrome 1', 'myotonic dystrophy type 1', 'nail-patella syndrome', 'autosomal dominant progressive nephropathy with hypertension', 'ovarian cancer', 'Peyronie disease', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'Hutchinson-Gilford progeria syndrome', 'familial juvenile hyperuricemic nephropathy type 1', 'Peutz-Jeghers syndrome', 'prostate cancer', 'pseudoachondroplasia', 'autosomal dominant distal renal tubular acidosis', 'retinoblastoma', 'Smith-Magenis syndrome', 'spondyloepiphyseal dysplasia tarda, autosomal dominant', 'spondyloepimetaphyseal dysplasia, Strudwick type', 'spondylometaphyseal dysplasia, Kozlowski type', 'spondylometaphyseal dysplasia, Schmidt type', 'proximal symphalangism', 'syndactyly type 5', 'brachydactyly-elbow wrist dysplasia syndrome', 'tarsal-carpal coalition syndrome', 'thoracolaryngopelvic dysplasia', 'tooth and nail syndrome', 'volvulus of midgut', 'short-limb skeletal dysplasia with severe combined immunodeficiency', 'acrocallosal syndrome', 'acrodermatitis enteropathica', 'acromesomelic dysplasia 2C, Hunter-Thompson type', 'agnathia-otocephaly complex', 'autosomal recessive Alport syndrome', 'amelogenesis imperfecta type 1G', 'microphthalmia with limb anomalies', 'progressive pseudorheumatoid arthropathy of childhood', 'Bloom syndrome', 'kyphomelic dysplasia', 'lung cancer', 'heart defects-limb shortening syndrome', 'chordoma', 'Juberg-Hayward syndrome', 'Costello syndrome', 'cystic fibrosis', 'hereditary renal hypouricemia', 'diastrophic dysplasia', 'Dyggve-Melchior-Clausen disease', 'Ehlers-Danlos syndrome, dermatosparaxis type', 'multiple epiphyseal dysplasia type 4', 'classic Hodgkin lymphoma', 'immunodeficiency, common variable, 2', 'ichthyosis-intellectual disability-dwarfism-renal impairment syndrome', 'Nezelof syndrome', 'spondylometaphyseal dysplasia, Sedaghatian type', 'metaphyseal dysostosis-intellectual disability-conductive deafness syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'carnitine palmitoyl transferase II deficiency, myopathic form', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'nail-patella-like renal disease', 'nephronophthisis 1', 'congenital nephrotic syndrome, Finnish type', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'human papilloma virus infection', 'fibrosarcoma', 'benign neoplasm', 'hypertrophy', 'anaplastic astrocytoma', 'cardiac hypertrophy', 'medical procedure', 'AIDS dementia', 'juvenile idiopathic arthritis', 'insulin resistance', 'prostate intraepithelial neoplasia', 'septic peritonitis', 'vulvar intraepithelial neoplasia', 'renal carcinoma', 'thyroid carcinoma', 'metastatic melanoma', 'pancreatic carcinoma', 'rotavirus infection', 'Cutaneous T-cell lymphoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'muscular disease', 'transitional cell carcinoma of kidney', 'anaplastic large cell lymphoma', 'bacteriemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'peripheral neuropathy', 'testicular seminoma', 'pneumonia', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'refractory anemia with ringed sideroblasts', 'laryngeal neoplasm', 'lung disease', 'brain neoplasm', 'calcification', 'retinopathy', 'thyroid neoplasm'], tissue_specific_expression={'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\"small intestine Peyer's patch\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}, is_essential=False, genetic_constraint={'syn': -0.12650999426841736, 'mis': 4.360300064086914, 'lof': 0.9999799728393555}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.', '*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'breast\\\\': 0, \\\\'atrium auricular region\\\\': 1, \\\\'liver\\\\': 0, \\\\'skeletal muscle tissue\\\\': 1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\\'esophagus mucosa\\\\': 1, \\\\'macrophage\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'segmented neutrophil of bone marrow\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': -1, \\\\'class switched memory B cell\\\\': 0, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 3, \\\\'Brodmann (1909) area 9\\\\': 0, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 1, \\\\'zone of skin\\\\': 1, \\\\'leukocyte\\\\': 0, \\\\'nasopharynx\\\\': -1, \\\\'tonsil\\\\': 0, \\\\'frontal lobe\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'putamen\\\\': 0, \\\\'hematopoietic stem cell\\\\': -1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'testis\\\\': -1, \\\\'bronchus\\\\': -1, \\\\'sigmoid colon\\\\': 0, \\\\'fallopian tube\\\\': 0, \\\\'plasma cell\\\\': -1, \\\\'aorta\\\\': 0, \\\\'adrenal gland\\\\': -1, \\\\'kidney\\\\': 0, \\\\'endometrium\\\\': 0, \\\\'smooth muscle tissue\\\\': 0, \\\\'tibial artery\\\\': 0, \\\\'prefrontal cortex\\\\': 0, \\\\'CD8-positive, alpha-beta T cell\\\\': -1, \\\\'vermiform appendix\\\\': 0, \\\\'lymph node\\\\': 0, \\\\'duodenum\\\\': 0, \\\\'mature eosinophil\\\\': 0, \\\\'prostate gland\\\\': 1, \\\\'C1 segment of cervical spinal cord\\\\': -1, \\\\'lung\\\\': 0, \\\\'inflammatory macrophage\\\\': -1, \\\\'rectum\\\\': 0, \\\\'suprapubic skin\\\\': 0, \\\\'brain\\\\': -1, \\\\'coronary artery\\\\': 0, \\\\'parathyroid gland\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': 0, \\\\'esophagus muscularis mucosa\\\\': 0, \\\\'esophagus\\\\': 1, \\\\'transformed skin fibroblast\\\\': 1, \\\\'heart muscle\\\\': -1, \\\\'pancreas\\\\': 0, \\\\'uterus\\\\': 0, \\\\'placenta\\\\': 0, \\\\'seminal vesicle\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'endothelial cell of umbilical vein (resting)\\\\': 0, \\\\'minor salivary gland\\\\': 0, \\\\'endocervix\\\\': 1, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'CD8-positive, alpha-beta thymocyte\\\\': -1, \\\\'granulocyte monocyte progenitor cell\\\\': -1, \\\\'caudate nucleus\\\\': 0, \\\\'amygdala\\\\': 0, \\\\'temporal lobe\\\\': 0, \\\\'substantia nigra\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'common lymphoid progenitor\\\\': 0, \\\\'cerebral cortex\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 0, \\\\'blood\\\\': -1, \\\\'nucleus accumbens\\\\': 0, \\\\'stomach\\\\': 0, \\\\'oral mucosa\\\\': -1, \\\\'mature neutrophil\\\\': 0, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'bone marrow\\\\': -1, \\\\'gall bladder\\\\': 1, \\\\'colon\\\\': 0, \\\\'cytotoxic CD56-dim natural killer cell\\\\': -1, \\\\'pituitary gland\\\\': 0, \\\\'transverse colon\\\\': 0, \\\\'heart left ventricle\\\\': 0, \\\\'erythroblast\\\\': -1, \\\\'vagina\\\\': 1, \\\\'ovary\\\\': 1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': 1, \\\\'cerebellum\\\\': -1, \\\\'hypothalamus\\\\': -1, \\\\'common myeloid progenitor\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': -1, \\\\'alternatively activated macrophage\\\\': -1, \\\\'thyroid gland\\\\': 1, \\\\'lower leg skin\\\\': 0, \\\\'epididymis\\\\': -1, \\\\'spleen\\\\': 0, \\\\'esophagogastric junction\\\\': 0, \\\\'greater omentum\\\\': 1, \\\\'memory B cell\\\\': 0, \\\\'hippocampus proper\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': -1, \\\\'small intestine\\\\': 1, \\\\'conventional dendritic cell\\\\': -1, \\\\'cortex of kidney\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": 0, \\\\'heart\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': -1, \\\\'caudate-putamen\\\\': -1, \\\\'urinary bladder\\\\': 1, \\\\'ectocervix\\\\': 1, \\\\'regulatory T cell\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 1, \\\\'saliva-secreting gland\\\\': 0, \\\\'neutrophilic metamyelocyte\\\\': -1, \\\\'tibial nerve\\\\': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets', 'reactome_pathways'])}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 2, 'used_tools': ['BioGRID', 'MSigDB', 'chembl', 'drug_central', 'extract_entities', 'prot', 'uniprot_base'], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID', 'OpenTargets', 'reactome', 'humanbase_functions', 'Summarize_GO'], 'ui': {}, 'prot_html': '\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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    \\\\n\\\\n\\\\n', 'drug_central_html': '', 'aa_seq_html': '', 'text_notes': []}\\n[TOOL RUN] → humanbase_functions\\n{'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id='Q15796', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma'], diseases=['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], pathways=['SMAD2/3 Phosphorylation Motif Mutants in Cancer', 'Developmental Biology', 'Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer', 'Deubiquitination', 'TGF-beta receptor signaling activates SMADs', 'Signaling by TGFB family members', 'Loss of Function of TGFBR1 in Cancer', 'Signaling by TGF-beta Receptor Complex', 'TGFBR1 KD Mutants in Cancer', 'Post-translational protein modification', 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes', 'Disease', 'Generic Transcription Pathway', 'Metabolism of proteins', 'Gene expression (Transcription)', 'Signal Transduction', 'FOXO-mediated transcription', 'Gastrulation', 'RNA Polymerase II Transcription', 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription', 'FOXO-mediated transcription of cell cycle genes', 'Loss of Function of SMAD2/3 in Cancer', 'Transcriptional regulation of pluripotent stem cells', 'SMAD4 MH2 Domain Mutants in Cancer', 'Diseases of signal transduction by growth factor receptors and second messengers', 'Formation of axial mesoderm', 'Germ layer formation at gastrulation', 'Downregulation of TGF-beta receptor signaling', 'Formation of definitive endoderm', 'Ub-specific processing proteases', 'Loss of Function of SMAD4 in Cancer', 'Downregulation of SMAD2/3:SMAD4 transcriptional activity', 'SMAD2/3 MH2 Domain Mutants in Cancer', 'Signaling by Activin', 'Signaling by TGF-beta Receptor Complex in Cancer', 'Signaling by NODAL'], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['SMAD3', 'SMAD4', 'SMURF2'], 'Affinity Capture-MS': ['ARID1A', 'ARID1B', 'ASH2L', 'ATAD3B', 'BCL7A', 'BTBD9', 'BUB3', 'C1ORF116', 'CAD', 'CCT6A', 'CDC27', 'CGA', 'CPSF7', 'CREBBP', 'CSNK1D', 'CTNNB1', 'CUL4A', 'CUL4B', 'DCAF7', 'DDX3Y', 'DGKA', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'EPB41L5', 'ERBB2IP', 'EZH2', 'FAM83G', 'FLOT1', 'FLOT2', 'FYN', 'GSK3A', 'GTF3C2', 'GTF3C6', 'HCFC1', 'HDAC2', 'HDAC4', 'HINT3', 'HSPA4', 'ITGB4', 'KLF5', 'KMT2C', 'LDLRAD4', 'LEMD3', 'MED15', 'MED16', 'MED17', 'MED19', 'MED20', 'MED22', 'MED25', 'MED31', 'MED4', 'MED9', 'MEN1', 'MTMR4', 'NCOA3', 'OGT', 'OPA1', 'OTUB1', 'PARK2', 'PCBP1', 'PCID2', 'PLEKHA4', 'PSPC1', 'RIN1', 'SGSH', 'SIK3', 'SKI', 'SKIL', 'SLC25A3', 'SLC25A5', 'SLC25A6', 'SMAD1', 'SMAD3', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMARCD2', 'SMPDL3B', 'SMURF2', 'SNW1', 'SNX27', 'SQRDL', 'TAF1', 'TAF2', 'TAF3', 'TAF5', 'TAF6', 'TMED8', 'TMOD1', 'TRIM28', 'TRIM33', 'TRIM67', 'U2AF2', 'WDR82', 'WRNIP1', 'WWP2', 'YAF2', 'YY1', 'ZFYVE9'], 'Affinity Capture-RNA': ['DDX58', 'ELAVL1'], 'Affinity Capture-Western': ['ACVR1B', 'ACVR2B', 'AKT1', 'ANAPC10', 'ATF3', 'BRCA2', 'CDC16', 'CDC27', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DAB2', 'DOCK9', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'ETV4', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'FOXP1', 'GLI1', 'GTF2I', 'GTF2IRD1', 'HDAC1', 'HGS', 'HYAL2', 'ING2', 'INSR', 'IRF3', 'IRF7', 'ITCH', 'JUN', 'KAT2A', 'KAT2B', 'KDM6B', 'KLF5', 'LEF1', 'MAPT', 'MED15', 'MED24', 'MED6', 'MEF2A', 'METTL14', 'METTL3', 'MYC', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFYC', 'NOTCH4', 'NUP214', 'OTUB1', 'OVOL2', 'PIAS3', 'PIAS4', 'PIN1', 'PML', 'PRDM16', 'RBBP5', 'RELB', 'RGCC', 'RNF111', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD6', 'SMAD7', 'SMARCA4', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'STRAP', 'TCF12', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TP53', 'TRIM28', 'TRIM33', 'TSC2', 'UCHL1', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWP1', 'WWP2', 'YAP1', 'ZEB1', 'ZFYVE9'], 'Biochemical Activity': ['ACVR1B', 'CAMK2G', 'CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'ITCH', 'TGFBR1'], 'Co-crystal Structure': ['SMAD4'], 'Co-fractionation': ['AP1M1', 'ARID1B', 'CAV1', 'CREBBP', 'CTNNB1', 'HDAC1', 'HMGA2', 'MTA2', 'NAA15', 'NCOA3', 'PARP1', 'PML', 'PRKDC', 'RBM14', 'RELA', 'SMAD3', 'SMAD4', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SUB1', 'TGFBR1', 'TRIM33', 'XRCC6', 'ZFYVE9'], 'Co-localization': ['CAMK2A', 'TGFBR1', 'TP53'], 'FRET': ['BECN1', 'LATS2', 'MYC', 'SMAD1'], 'Phenotypic Enhancement': ['SMAD3', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['SPPL3'], 'Proximity Label-MS': ['CCNF', 'EPHA2', 'OPTN', 'RAB7A', 'SNCA', 'TGOLN2'], 'Reconstituted Complex': ['ANAPC10', 'ANP32B', 'ANP32E', 'ATP5I', 'BPTF', 'CREBBP', 'DAB2', 'DVL1', 'ELAC2', 'ERBB2IP', 'ESR1', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'HDAC2', 'HIPK2', 'HYAL2', 'INSR', 'IRF7', 'JUN', 'KAT2B', 'LCK', 'LEF1', 'MECOM', 'MEF2A', 'MEF2C', 'MYC', 'MYOCD', 'NEDD4L', 'NEFM', 'NFIA', 'NUP214', 'OTUB1', 'PARD3', 'PIAS3', 'PIK3CA', 'PIN1', 'PTMS', 'RHOA', 'SH2D2A', 'SKI', 'SMAD4', 'SMAD7', 'SMURF2', 'SNW1', 'SOD1', 'SP1', 'STUB1', 'SYT1', 'TP53', 'TUBA1B', 'UCHL5', 'YY1', 'ZFYVE9'], 'Two-hybrid': ['ABTB1', 'AKT1', 'ANAPC2', 'ANK3', 'ANTXR2', 'BAZ1A', 'BTBD2', 'C22ORF46', 'C9ORF156', 'CISH', 'COPS5', 'CORO2A', 'CREBBP', 'CSH1', 'CSH2', 'CUL5', 'CYLC2', 'CYP11A1', 'DCUN1D1', 'DNAJB5', 'DNAJC7', 'DOCK8', 'DYNC1H1', 'DYRK1A', 'EEF1A1', 'EIF3L', 'EP300', 'ETV4', 'FAM161B', 'FBP2', 'FOXH1', 'GATAD2B', 'GFER', 'HSD17B3', 'INSR', 'KHDRBS1', 'KIAA1033', 'KPNB1', 'LAMA5', 'LEMD3', 'MAP2K1', 'MLLT4', 'MYC', 'NAGK', 'NCOA6', 'NEDD4L', 'OS9', 'PAPOLA', 'PAPPA', 'PAXIP1', 'PEX19', 'PIAS4', 'PLIN3', 'POU2AF1', 'PPP2R1A', 'PRKAR1A', 'PSAP', 'PSG9', 'PSMD11', 'PSMD8', 'RANBP6', 'RANBP9', 'RARB', 'RASA1', 'RNF123', 'RNPC3', 'ROCK1', 'RPS14', 'RPS27A', 'RXRA', 'SKI', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD9', 'SMURF1', 'SMURF2', 'SNAPIN', 'SNIP1', 'SNRNP70', 'SNW1', 'SP1', 'SRI', 'ST13', 'ST5', 'TBC1D1', 'TGIF1', 'TGM2', 'TRIM62', 'UBA52', 'UBR5', 'XPA', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF41', 'ZNF510', 'ZNHIT6']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF1', 'ARHGEF6', 'ARHGEF7', 'ARL4D', 'CDC40', 'FBXO3', 'IRAK2', 'LHX9', 'LMO2', 'MAP2K3', 'NUAK2', 'PPP2R2D', 'RAB34', 'RAB38', 'RASD2', 'RGS3', 'RHEBL1', 'RHOBTB1', 'RHOD', 'RHOJ', 'RPS27A', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'UHMK1', 'WWP2'], 'Affinity Capture-MS': ['ALDH4A1', 'BACH1', 'E6', 'FANCD2', 'NSP16AB', 'OTUB1', 'PAXIP1', 'RUNX1'], 'Affinity Capture-Western': ['COL1A1', 'COL3A1', 'COL5A1', 'DOK1', 'E6', 'E7', 'GATA4', 'HCVGP1', 'KAP-ALPHA3', 'KLF4', 'LEF1', 'MED', 'MED15', 'MEF2A', 'RNF111', 'SKI', 'SMAD2', 'SMAD4', 'SMOX', 'SNOO', 'UBX', 'VIS', 'WWTR1', 'YAP1'], 'Co-localization': ['E7', 'EZH2-A', 'KLF4'], 'PCA': ['E6', 'SMOX'], 'Phenotypic Enhancement': ['BABO', 'INR', 'SMOX', 'YKI'], 'Phenotypic Suppression': ['BABO', 'HPO', 'INR', 'MYO', 'PLUM', 'PTEN', 'SCGDELTA', 'SMOX'], 'Reconstituted Complex': ['E7', 'LEMD3', 'SMAD2', 'SOX9', 'UBX', 'ZFP128'], 'Two-hybrid': ['CG18095', 'D', 'E6', 'EG', 'FOXH1', 'HOXA13', 'HOXD13', 'HR78', 'SMAD2', 'SMOX', 'UBX', 'ZEB2', 'ZEN']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Overgrowth', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Myocardial fibrosis', 'Increased total eosinophil count', 'Thrombocytosis', 'Anemia', 'Acute kidney injury', 'Glucose intolerance', 'Pulmonary hypoplasia', 'Pneumonia', 'Asthma', 'Ischemic stroke', 'Cerebral ischemia', 'Vascular dilatation', 'Aortic dissection', 'Systemic lupus erythematosus', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Skeletal muscle atrophy', 'Muscular dystrophy', 'Cachexia', 'Thrombophlebitis', 'Miscarriage', 'Ureteral obstruction', 'Airway obstruction', 'Amyotrophic lateral sclerosis', 'Peripheral demyelination', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Reduced sperm motility', 'Urethral stricture', 'Renal atrophy', 'Cervical polyp', 'Shock', 'Granuloma', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Sepsis', 'geleophysic dysplasia', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'hydronephrosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'renal cell adenocarcinoma', 'Autoimmune Hepatitis', 'neurodegenerative disease', 'brain disease', 'aortic disease', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'head and neck neoplasia', 'breast ductal adenocarcinoma', 'laryngeal squamous cell carcinoma', 'ovarian adenocarcinoma', 'ovarian mucinous adenocarcinoma', 'ovarian teratoma', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'dysplastic oral keratinocyte', 'undifferentiated carcinoma', 'cerebral amyloid angiopathy', 'head and neck malignant neoplasia', 'breastfeeding duration', 'urgency urinary incontinence', 'fibrosis', 'Balkan nephropathy', 'congenital rubella', 'echinococcosis', 'Gerstmann syndrome', 'inclusion body myositis', 'muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10', 'severe neurodegenerative syndrome with lipodystrophy', 'Diamond-Blackfan anemia', 'cardiofaciocutaneous syndrome', 'adrenomyeloneuropathy', 'hereditary sensory and autonomic neuropathy', 'nasopharyngeal carcinoma', 'keratoconus', 'dentin dysplasia', 'T-cell non-Hodgkin lymphoma', 'dyskeratosis congenita', 'pneumoconiosis', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'cryopyrin-associated periodic syndrome', 'holoprosencephaly', 'pachyonychia congenita', 'familial rhabdoid tumor', 'familial hyperaldosteronism', 'primary ciliary dyskinesia', 'meningioma', 'pilocytic astrocytoma', 'hemangioblastoma', 'microcephaly-brain defect-spasticity-hypernatremia syndrome', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'heritable pulmonary arterial hypertension', 'juvenile polyposis syndrome', 'congenital herpes simplex virus infection', 'popliteal pterygium syndrome', 'ameloblastoma', 'hypersensitivity pneumonitis', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'emphysema', 'epilepsy', 'esophageal adenocarcinoma', 'fetal growth restriction', 'follicular thyroid adenoma', 'ganglioneuroma', 'follicular thyroid carcinoma', 'gastric adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'genetic disorder', 'germ cell tumor', 'glioblastoma multiforme', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'large cell neuroendocrine carcinoma', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'neural tube defect', 'tuberculosis', 'glioblastoma', 'carcinoma of liver and intrahepatic biliary tract', 'hereditary nonpolyposis colon cancer', 'Zika virus infectious disease', 'left ventricular noncompaction', 'multiminicore myopathy', 'Loeys-Dietz syndrome', 'neurofibromatosis type 1', 'Leber congenital amaurosis', 'osteogenesis imperfecta', 'progressive supranuclear palsy', 'intrahepatic cholestasis', 'lymphedema', 'posterior cortical atrophy', 'follicular lymphoma', 'kidney Wilms tumor', 'bronchopulmonary dysplasia', 'sarcoidosis', 'peeling skin syndrome', 'lissencephaly with cerebellar hypoplasia', 'aggressive NK-cell leukemia', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'familial thoracic aortic aneurysm and aortic dissection', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'precursor B-cell acute lymphoblastic leukemia', 'superficial spreading melanoma', 'lung neoplasm', 'intestinal neoplasm', 'odontogenic neoplasm', 'disorder of ear', 'endometrium neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'carcinoma of pharynx', 'polyp of colon', 'low grade glioma', 'corticobasal degeneration disorder', 'cervical intraepithelial neoplasia', 'viral myocarditis', 'lip and oral cavity carcinoma', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'chondrogenic neoplasm', 'intraepithelial neoplasia', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'pulmonary sarcoidosis', 'gonorrhea', 'B-cell acute lymphoblastic leukemia', 'chronic lymphocytic leukemia', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'myelodysplastic syndrome', 'oral squamous cell carcinoma', 'gastritis', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'acute promyelocytic leukemia', 'adenocarcinoma', 'adenoma', 'age', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', \\\"Barrett's esophagus\\\", 'benign prostatic hyperplasia', 'bladder tumor', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'central nervous system cancer', 'chondrosarcoma', 'chromophobe renal cell carcinoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'clear cell renal carcinoma', 'endometrial carcinoma', 'ovarian serous carcinoma', 'renal fibrosis', 'Abruptio Placentae', 'Adenomyosis', 'Carcinoma, Lewis Lung', 'chronic myelomonocytic leukemia', 'Marchiafava-Bignami Disease', 'oral submucous fibrosis', 'osteoradionecrosis', 'renal nutcracker syndrome', 'amyloidosis', 'mucositis', 'neuroendocrine neoplasm', 'neuromuscular disease', 'oral mucositis', 'Spinal cord injury', 'cutaneous squamous cell carcinoma', 'Barrett adenocarcinoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'pharyngeal squamous cell carcinoma', 'soft tissue sarcoma', 'undifferentiated pleomorphic sarcoma', 'connective tissue disease', 'pneumonitis', 'intrahepatic cholangiocarcinoma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'glomerular disease', 'nephritis', 'Neurogenic bladder', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Uterine leiomyoma', 'Cleft palate', 'Hydrocephalus', 'Cataract', 'Myopia', 'Autism', 'Infertility', 'Diabetes mellitus', 'Insulin resistance', 'Osteoporosis', 'Hyperkeratosis', 'Intellectual disability', 'Ataxia', 'Mental deterioration', 'Stroke', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Hepatic steatosis', 'Obesity', 'mixed connective tissue disease', 'pneumocystosis', 'pseudomyxoma peritonei', 'silicosis', 'toxoplasmosis', 'hemoglobin A1 measurement', 'BMI-adjusted waist-hip ratio', 'liver dysplastic nodule', 'gut microbiome measurement', 'platelet crit', 'allergen exposure measurement', 'calf circumference measurement', 'dysplasia', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'digestive system neoplasm', 'Hepatobiliary Neoplasm', 'American trypanosomiasis', 'acute myocardial infarction', 'pemphigus foliaceus', 'cystic kidney disease', 'Polycystic Kidney Disease', 'arteriosclerosis', 'hyperuricemia', 'skin carcinoma', 'heel bone mineral density', 'pulmonary fibrosis', 'hyperaldosteronism', 'gastric ulcer', 'infarction', 'aortic valve disease', 'heart valve disease', 'mitral valve disease', 'urinary tract obstruction', 'prostate disease', 'stomach disease', 'myocarditis', 'aneurysm', 'enthesopathy', 'musculoskeletal system disease', 'metastasis', 'Gallbladder Adenocarcinoma', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Malignant Mesothelioma', 'Malignant Pancreatic Neoplasm', 'Medullomyoblastoma with Myogenic Differentiation', 'Microcystic Meningioma', 'Mixed Tumor of the Salivary Gland', 'Nasal Cavity Polyp', 'Osteoblastoma', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Paraganglioma', 'Placental Choriocarcinoma', 'Rectal Tubular Adenoma', 'Sarcomatoid Carcinoma', 'Signet Ring Cell Gastric Adenocarcinoma', 'Synovial Chondromatosis', 'Testicular Non-Seminomatous Germ Cell Tumor', 'Testicular Yolk Sac Tumor', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vulvar Squamous Cell Carcinoma', 'acute respiratory distress syndrome', 'sarcopenia', 'rectum cancer', 'acanthosis nigricans', 'mucous membrane pemphigoid', 'punctate palmoplantar keratoderma type III', 'adrenal cortex carcinoma', 'alcoholic liver cirrhosis', 'atrophic gastritis', 'dental fluorosis', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'multiple system atrophy', 'myeloid sarcoma', 'nodular goiter', 'periapical granuloma', 'pulmonary edema', 'renovascular hypertension', 'retinopathy of prematurity', 'rheumatic heart disease', 'thromboangiitis obliterans', 'tooth disease', 'uremia', 'non-alcoholic steatohepatitis', 'Cryptogenic Organizing Pneumonia', 'Fascioliasis', 'Follicular Cyst', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Myocardial Ischemia', 'Pelvic Inflammatory Disease', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Pneumonia, Aspiration', 'Respiratory Syncytial Virus Infection', 'diabetic cardiomyopathy', 'diabetic foot', 'endothelial dysfunction', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'schistosomiasis', 'abortion', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'Bartsocas-Papas syndrome 1', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'SHOX-related short stature', 'intellectual disability, X-linked syndromic, Turner type', 'Fabry disease', 'X-linked corneal dermoid', 'Aarskog-Scott syndrome, X-linked', 'holoprosencephaly-hypokinesia-congenital contractures syndrome', 'Melnick-Needles syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'Wilson disease', 'adenomyosis', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'Ehlers-Danlos syndrome, musculocontractural type', 'tetrasomy 12p', 'sickle cell anemia', 'hypotonia-cystinuria syndrome', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'autoimmune lymphoproliferative syndrome type 2B', 'endometrial cancer', 'Loeys-Dietz syndrome 1', 'hyperinsulinemic hypoglycemia, familial, 4', 'preterm premature rupture of the membranes', 'Mungan syndrome', 'Crouzon syndrome-acanthosis nigricans syndrome', 'papillary renal cell carcinoma', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'pterygium', 'renal cell carcinoma', 'rheumatoid arthritis', 'sarcoma', 'severe acute respiratory syndrome', 'small cell lung carcinoma', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'spondyloarthropathy', 'stroke', 'subarachnoid hemorrhage', 'systemic scleroderma', 'ulcerative colitis', 'melanoma', 'hepatocellular adenoma', 'viral disease', 'HIV infection', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'pneumococcal infection', 'temporal lobe epilepsy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'malaria', 'folate deficiency', 'lung carcinoma', 'ovarian carcinoma', 'familial amyotrophic lateral sclerosis', 'pulmonary arterial hypertension', 'age-related macular degeneration', 'synovial sarcoma', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'villous adenoma', 'mucosal melanoma', 'ovarian clear cell cancer', 'central nervous system primitive neuroectodermal neoplasm', 'Crohn ileitis', 'vertebral column disorder', 'endometrial disorder', 'gastric cancer', 'penile cancer', 'myopia', 'pulmonary alveolar proteinosis', 'Chagas disease', 'leiomyoma', 'brain cancer', 'tuberous sclerosis', 'sick sinus syndrome', 'arteriovenous hemangioma/malformation', 'hypertensive heart disease', 'head and neck carcinoma', 'depressive disorder', 'pneumothorax', 'Richter syndrome', 'peritoneum cancer', 'thyroid cancer', 'disorder of sexual differentiation', 'vulvar melanoma', 'papilloma', 'rectosigmoid junction neoplasm', 'Treacher-Collins syndrome', 'prostatic acinar adenocarcinoma', 'gingival overgrowth', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratoma', 'bone inflammation disease', 'extraosseous osteosarcoma', 'chondroblastic osteosarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'lung benign neoplasm', 'skin cancer', 'cervical cancer', 'seminoma', 'breast angiosarcoma', 'cerebellar pilocytic astrocytoma', 'salivary gland adenoid cystic carcinoma', 'bile duct adenocarcinoma', 'gastroesophageal junction adenocarcinoma', 'thoracic cancer', 'acral lentiginous melanoma', 'endometrial mixed adenocarcinoma', 'female breast carcinoma', 'inflammation', 'erythrocyte volume', 'glomerular filtration rate', 'bone tissue density', 'progesterone amount', 'serum alanine aminotransferase amount', 'serum urea amount', 'serum creatinine amount', 'body height', 'cyst', 'Hypotonia - cystinuria syndrome', 'Chédiak-Higashi syndrome', 'Åland Islands eye disease', 'Hydrocephalus with stenosis of the aqueduct of Sylvius', 'Autoimmune lymphoproliferative syndrome with recurrent viral infections', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Persistent Müllerian duct syndrome', 'WHIM syndrome', 'Familial adenomatous polyposis', 'Other metabolic disease', 'hematocrit', 'C-reactive protein measurement', 'hematological measurement', 'alkaline phosphatase measurement', 'cryptorchidism', 'lymphocyte count', 'gestational diabetes', 'acute lung injury', 'serum gamma-glutamyl transferase measurement', 'HbA1c measurement', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'wet macular degeneration', 'insomnia', 'hypothyroidism', 'pelvic organ prolapse', 'metabolite measurement', 'eosinophil count', 'lymph node metastatic carcinoma', 'embryonal carcinoma', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'monocyte count', 'autoimmune disease', 'congenital heart disease', 'cholangiocarcinoma', 'human african trypanosomiasis', 'reading', 'congenital heart malformation', 'temporomandibular joint disorder', 'axial length measurement', 'myeloid leukemia', 'lupus erythematosus', 'allergic asthma', 'fatty liver disease', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'cataract', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'multiple sclerosis', 'skin basal cell carcinoma', 'brain glioma', 'colorectal cancer', 'Wilms tumor', 'Townes-Brocks syndrome', 'nevoid basal cell carcinoma syndrome', 'breast cancer', 'congenital contractural arachnodactyly', 'Duane retraction syndrome', 'dyschromatosis symmetrica hereditaria', 'metastatic malignant neoplasm', 'Loeys-Dietz syndrome 6', 'cervical squamous intraepithelial neoplasia', 'leukoplakia', 'spinal cord injury', 'ulcer disease', 'desmoplastic melanoma', 'myelofibrosis', 'oral cavity carcinoma', 'rectal carcinoma', 'hydrocephalus, congenital, 3, with brain anomalies', 'nasal cavity and paranasal sinus carcinoma', 'COVID-19', 'Dravet syndrome', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'achalasia-alacrima syndrome', 'metabolic bone disorder', 'congenital heart defects, multiple types, 8, with or without heterotaxy', 'postmenopausal osteoporosis', 'intestinal polyp', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'breast neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'stomach neoplasm', 'ankylosing spondylitis', 'ciliopathy', 'deep vein thrombosis', 'obstructive sleep apnea', 'necrotizing enterocolitis', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'atherosclerosis', 'open-angle glaucoma', 'androgenetic alopecia', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'focal segmental glomerulosclerosis', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'myeloproliferative disorder', 'nephrotic syndrome', 'vascular disease', 'thoracic aortic aneurysm', 'venous thromboembolism', 'platelet count', 'body mass index', 'neuroimaging measurement', 'metastatic neoplasm', 'whole body water mass', 'kidney injury', 'bone metastasis', 'gastrointestinal disease', 'aspartate aminotransferase to alanine aminotransferase ratio', 'urea measurement', 'viral load', '2-hydroxyacetaminophen sulfate measurement', 'aging', 'serum lipopolysaccharide activity', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'ependymoma', 'granulosa cell tumor', 'metaplastic breast carcinoma', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'ACTH-Producing Pituitary Gland Adenoma', 'Adenomatoid Odontogenic Tumor', 'Ampulla of Vater Carcinoma', 'Anal Squamous Cell Carcinoma', 'Anaplastic (Malignant) Meningioma', 'Appendix Adenocarcinoma', 'Appendix Goblet Cell Carcinoid', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Breast Carcinoma by Gene Expression Profile', 'cervical squamous cell carcinoma', 'Columnar Cell Hyperplasia of the Breast', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Extramammary Paget Disease', 'fibrodysplasia ossificans progressiva', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'Pallister-Hall syndrome', 'Nager acrofacial dysostosis', 'Marfan syndrome', 'Cowden syndrome 1', 'nail-patella syndrome', 'ovarian cancer', 'Andersen-Tawil syndrome', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'nonpapillary renal cell carcinoma', 'Mobius syndrome', 'Peyronie disease', 'prostate cancer', 'retinoblastoma', 'acrodermatitis enteropathica', 'mitochondrial DNA depletion syndrome 4a', 'Alstrom syndrome', 'anencephaly 1', 'microphthalmia with limb anomalies', 'Bloom syndrome', 'lung cancer', 'cerebrotendinous xanthomatosis', 'cystic fibrosis', 'recessive dystrophic epidermolysis bullosa', 'Haim-Munk syndrome', 'Laurence-Moon syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'ischemic cardiomyopathy', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'fibrosarcoma', 'hypertrophy', 'actinic keratosis', 'anaplastic astrocytoma', 'anaplastic oligodendroglioma', 'cardiac hypertrophy', 'AIDS dementia', 'pancreatic carcinoma', 'prostate intraepithelial neoplasia', 'thyroid carcinoma', 'insulin resistance', 'esophageal carcinoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'acute megakaryoblastic leukaemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'pleomorphic liposarcoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'Pick disease', 'testicular seminoma', 'osteomyelitis', 'spina bifida', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'lung disease', 'dental caries', 'serous adenocarcinoma', 'retinopathy', 'adrenal gland neoplasm'], tissue_specific_expression={'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\"small intestine Peyer's patch\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}, is_essential=False, genetic_constraint={'syn': 0.11195000261068344, 'mis': 4.47730016708374, 'lof': 1.0}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.', '*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett\\\\'s esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'frontal lobe\\\\': -1, \\\\'endothelial cell of umbilical vein (resting)\\\\': 2, \\\\'zone of skin\\\\': 0, \\\\'regulatory T cell\\\\': 1, \\\\'pancreas\\\\': -1, \\\\'suprapubic skin\\\\': -1, \\\\'temporal lobe\\\\': -1, \\\\'parathyroid gland\\\\': -1, \\\\'spleen\\\\': -1, \\\\'Brodmann (1909) area 9\\\\': -1, \\\\'breast\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': -1, \\\\'alternatively activated macrophage\\\\': 2, \\\\'segmented neutrophil of bone marrow\\\\': 4, \\\\'placenta\\\\': -1, \\\\'mature eosinophil\\\\': 1, \\\\'granulocyte monocyte progenitor cell\\\\': 0, \\\\'gall bladder\\\\': -1, \\\\'esophagus muscularis mucosa\\\\': -1, \\\\'seminal vesicle\\\\': -1, \\\\'endocervix\\\\': -1, \\\\'lower leg skin\\\\': -1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 2, \\\\'CD8-positive, alpha-beta T cell\\\\': 3, \\\\'cerebral cortex\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': 4, \\\\'hippocampus proper\\\\': -1, \\\\'uterus\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': 3, \\\\'tonsil\\\\': -1, \\\\'esophagus\\\\': 0, \\\\'transverse colon\\\\': -1, \\\\'pituitary gland\\\\': -1, \\\\'coronary artery\\\\': -1, \\\\'memory B cell\\\\': 0, \\\\'sigmoid colon\\\\': -1, \\\\'cerebellum\\\\': -1, \\\\'erythroblast\\\\': 2, \\\\'prefrontal cortex\\\\': -1, \\\\'nucleus accumbens\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'vermiform appendix\\\\': -1, \\\\'greater omentum\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': 1, \\\\'leukocyte\\\\': 2, \\\\'adrenal gland\\\\': -1, \\\\'atrium auricular region\\\\': -1, \\\\'thyroid gland\\\\': 0, \\\\'tibial artery\\\\': -1, \\\\'common lymphoid progenitor\\\\': 3, \\\\'urinary bladder\\\\': -1, \\\\'duodenum\\\\': -1, \\\\'heart muscle\\\\': -1, \\\\'small intestine\\\\': -1, \\\\'neutrophilic metamyelocyte\\\\': 3, \\\\'minor salivary gland\\\\': -1, \\\\'rectum\\\\': 0, \\\\'ovary\\\\': -1, \\\\'substantia nigra\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': -1, \\\\'class switched memory B cell\\\\': 1, \\\\'fallopian tube\\\\': -1, \\\\'esophagus mucosa\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 0, \\\\'bronchus\\\\': -1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": -1, \\\\'kidney\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'macrophage\\\\': 1, \\\\'aorta\\\\': -1, \\\\'skeletal muscle tissue\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': 4, \\\\'caudate-putamen\\\\': -1, \\\\'liver\\\\': -1, \\\\'cytotoxic CD56-dim natural killer cell\\\\': 2, \\\\'mature neutrophil\\\\': 2, \\\\'hypothalamus\\\\': -1, \\\\'transformed skin fibroblast\\\\': -1, \\\\'bone marrow\\\\': -1, \\\\'inflammatory macrophage\\\\': 0, \\\\'cortex of kidney\\\\': -1, \\\\'lung\\\\': -1, \\\\'epididymis\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'saliva-secreting gland\\\\': -1, \\\\'nasopharynx\\\\': -1, \\\\'colon\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'stomach\\\\': -1, \\\\'testis\\\\': -1, \\\\'smooth muscle tissue\\\\': 0, \\\\'putamen\\\\': -1, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 5, \\\\'C1 segment of cervical spinal cord\\\\': 0, \\\\'blood\\\\': -1, \\\\'hematopoietic stem cell\\\\': 1, \\\\'caudate nucleus\\\\': -1, \\\\'amygdala\\\\': -1, \\\\'brain\\\\': 0, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'ectocervix\\\\': -1, \\\\'prostate gland\\\\': -1, \\\\'conventional dendritic cell\\\\': 4, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'heart left ventricle\\\\': -1, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 0, \\\\'vagina\\\\': -1, \\\\'esophagogastric junction\\\\': -1, \\\\'lymph node\\\\': -1, \\\\'endometrium\\\\': -1, \\\\'heart\\\\': -1, \\\\'oral mucosa\\\\': -1, \\\\'CD8-positive, alpha-beta thymocyte\\\\': 4, \\\\'common myeloid progenitor\\\\': 0, \\\\'tibial nerve\\\\': -1, \\\\'plasma cell\\\\': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets', 'reactome_pathways']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id='P84022', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'], diseases=['Colorectal cancer', 'Loeys-Dietz syndrome 3'], pathways=['Cytokine Signaling in Immune system', 'Interleukin-1 family signaling', 'SMAD2/3 Phosphorylation Motif Mutants in Cancer', 'Developmental Biology', 'Viral Infection Pathways', 'Signaling by TGFBR3', 'Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer', 'Signaling by Interleukins', 'Deubiquitination', 'Signaling by NOTCH', 'TGF-beta receptor signaling activates SMADs', 'Signaling by TGFB family members', 'Loss of Function of TGFBR1 in Cancer', 'RUNX3 regulates CDKN1A transcription', 'SARS-CoV-1 targets host intracellular signalling and regulatory pathways', 'Signaling by TGF-beta Receptor Complex', 'TGFBR1 KD Mutants in Cancer', 'Post-translational protein modification', 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes', 'TGFBR3 expression', 'Disease', 'Generic Transcription Pathway', 'Metabolism of proteins', 'Gene expression (Transcription)', 'Signal Transduction', 'SARS-CoV-1-host interactions', 'FOXO-mediated transcription', 'Infectious disease', 'Gastrulation', 'RNA Polymerase II Transcription', 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription', 'NOTCH4 Intracellular Domain Regulates Transcription', 'FOXO-mediated transcription of cell cycle genes', 'Loss of Function of SMAD2/3 in Cancer', 'SMAD4 MH2 Domain Mutants in Cancer', 'Diseases of signal transduction by growth factor receptors and second messengers', 'SARS-CoV Infections', 'Formation of axial mesoderm', 'SARS-CoV-1 Infection', 'Germ layer formation at gastrulation', 'Signaling by NOTCH4', 'Downregulation of TGF-beta receptor signaling', 'Interleukin-37 signaling', 'Formation of definitive endoderm', 'RUNX3 regulates BCL2L11 (BIM) transcription', 'Ub-specific processing proteases', 'Loss of Function of SMAD4 in Cancer', 'Downregulation of SMAD2/3:SMAD4 transcriptional activity', 'Immune System', 'SMAD2/3 MH2 Domain Mutants in Cancer', 'Transcriptional regulation by RUNX3', 'Signaling by Activin', 'Signaling by TGF-beta Receptor Complex in Cancer', 'Signaling by NODAL'], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['BAG3', 'HIF1A', 'SMAD2', 'SMAD4', 'SMURF1', 'SMURF2', 'SP1'], 'Affinity Capture-MS': ['ARID1A', 'ATG14', 'ATG16L1', 'ATXN2L', 'BUB3', 'C1ORF116', 'CD6', 'CDK11A', 'CHD8', 'CIC', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DCAF4', 'DCAF7', 'DDX3X', 'DDX3Y', 'DDX4', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'DZIP3', 'EPB41L5', 'ERBB2IP', 'EVA1B', 'EZH2', 'FAM83G', 'FURIN', 'HINT3', 'HSPA4', 'IRF7', 'IRS1', 'ITGB4', 'KAT6A', 'KCTD16', 'LACRT', 'LDLRAD4', 'LEMD3', 'LRCH1', 'LSR', 'MAP2K3', 'MAPK1', 'MED16', 'MED4', 'NCOA3', 'NF2', 'OPA1', 'OTUB1', 'OTUD1', 'PABPC1', 'PARK2', 'PJA1', 'PLEKHA4', 'PPIE', 'PRNP', 'PSPC1', 'PTPN6', 'RAB11FIP5', 'RPL3', 'RPL4', 'RPSAP15', 'SIK3', 'SLC25A12', 'SLC9A3R2', 'SMAD1', 'SMAD2', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMURF2', 'SNW1', 'SQRDL', 'SUZ12', 'TAF1', 'TAF2', 'TCP1', 'TGFB1', 'TMEM192', 'TRIM33', 'TRIM67', 'TRIP4', 'U2AF2', 'UGT1A10', 'USP33', 'USP7', 'VAV2', 'WWP2', 'YTHDF2', 'YY1', 'ZFP69B', 'ZFYVE9', 'ZRANB1'], 'Affinity Capture-RNA': ['DDX58', 'TRIM25'], 'Affinity Capture-Western': ['ACTB', 'ACVR1B', 'AKT1', 'ANAPC10', 'AR', 'ATF2', 'ATF3', 'BACH1', 'BRCA1', 'BRCA2', 'BTRC', 'CBL', 'CDC16', 'CDC25A', 'CDC27', 'CDKN1A', 'CEBPD', 'CHRD', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CSNK1G2', 'CTCF', 'CTNNB1', 'CUL1', 'DAB2', 'DACH1', 'DEDD', 'DOCK9', 'E2F4', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXL2', 'FOXM1', 'FOXO1', 'FOXO3', 'FOXO4', 'GRIP1', 'GSK3B', 'HDAC4', 'HDAC5', 'HGS', 'HIF1A', 'HNF4A', 'HYAL2', 'ID1', 'IRF7', 'JUN', 'KAT2A', 'KAT2B', 'KAT6A', 'KDM5C', 'KDM6B', 'KLF5', 'KPNB1', 'LEF1', 'MAFK', 'MECOM', 'MED15', 'MED24', 'MED6', 'MEN1', 'METTL14', 'METTL3', 'MKL1', 'MYC', 'MYD88', 'MYOCD', 'NCOA1', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIC', 'NFYC', 'NOTCH1', 'NOTCH4', 'NR3C1', 'NR4A1', 'NUP214', 'OTUB1', 'OTUD1', 'OVOL2', 'PAX6', 'PCK2', 'PDLIM5', 'PIAS3', 'PIAS4', 'PIN1', 'PITX1', 'PITX2', 'PML', 'PPARG', 'PPP1R12C', 'PRDM16', 'PRTN3', 'RARA', 'RBBP5', 'RBL1', 'RBX1', 'RELB', 'RGCC', 'RNF111', 'RNF31', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SETD2', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD7', 'SMARCA4', 'SMARCC2', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'SQSTM1', 'SREBF2', 'SRY', 'STRAP', 'STUB1', 'SUV39H1', 'TCF12', 'TGFB1I1', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TGIF2', 'TOB1', 'TP53', 'TRIB3', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'TSC22D4', 'UCHL1', 'UCHL5', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWOX', 'WWP1', 'WWP2', 'YAP1', 'ZC3H12A', 'ZEB1', 'ZEB2', 'ZFYVE9', 'ZMIZ1'], 'Biochemical Activity': ['CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'CSNK1G2', 'MAPK1', 'NEDD4', 'NEDD4L', 'OTUB1', 'TGFBR1', 'USP15', 'USP7', 'WWP2'], 'Co-crystal Structure': ['SMAD3', 'SMAD4', 'ZFYVE9'], 'Co-fractionation': ['ALKBH2', 'ANAPC10', 'APP', 'ARID1B', 'CDH1', 'CREBBP', 'CTCF', 'CTNNB1', 'CUL1', 'DDR1', 'FOXO3', 'HDAC1', 'HMGA2', 'IGF1R', 'ITGB1', 'JUND', 'MTA2', 'NAA15', 'NT5DC3', 'PARP1', 'PRKDC', 'RBM14', 'RBX1', 'RELA', 'RIPK1', 'RNMT', 'SIN3A', 'SKP1', 'SMAD2', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SP1', 'SUB1', 'TRIM33', 'XRCC5', 'XRCC6', 'ZFHX3', 'ZFYVE9'], 'Co-localization': ['AKT1', 'BMP7', 'CAMK2G', 'CDK2', 'CDK4', 'EPAS1', 'ETS1', 'FOXO3', 'HIF1A', 'IRF7', 'MAP3K7', 'MAPK8', 'MAX', 'TP53', 'TRIM62'], 'Cross-Linking-MS (XL-MS)': ['RPL10A'], 'FRET': ['SMAD4', 'STUB1'], 'PCA': ['SMAD4', 'SMAD7'], 'Phenotypic Enhancement': ['HIF1A', 'SMAD2', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['JAK1'], 'Protein-RNA': ['LINC00941'], 'Protein-peptide': ['CREBBP', 'FOXH1', 'ITCH', 'LEF1', 'NEDD4', 'PIN1'], 'Proximity Label-MS': ['NFIA'], 'Reconstituted Complex': ['ANAPC10', 'APP', 'AR', 'ATF2', 'ATF3', 'BPTF', 'BRCA1', 'BRCA2', 'CEBPA', 'CEBPB', 'CEBPD', 'CITED2', 'CREBBP', 'CTCF', 'DAB2', 'DDX5', 'DEDD', 'DNMT3L', 'DVL1', 'E2F4', 'EID2', 'EIF4B', 'EP300', 'ERBB2IP', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXM1', 'GSK3B', 'HDAC1', 'HDAC4', 'HDAC5', 'HIF1A', 'HIPK2', 'HNF4A', 'HYAL2', 'IRF7', 'ITCH', 'JUN', 'JUNB', 'JUND', 'KAT2B', 'KAT6A', 'KPNB1', 'LCK', 'LEF1', 'LEMD3', 'MAX', 'MDM4', 'MECOM', 'MYC', 'MYOCD', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIA', 'NOTCH1', 'NR3C1', 'NUP153', 'NUP214', 'PARD3', 'PIAS2', 'PIAS3', 'PIAS4', 'PIK3CA', 'PIN1', 'RBL1', 'RUNX2', 'S100A4', 'SH2D2A', 'SIN3A', 'SKI', 'SKIL', 'SMAD3', 'SMAD4', 'SMURF2', 'SNW1', 'SP1', 'STUB1', 'TFE3', 'TGFB1I1', 'TGFBR1', 'TGIF1', 'TP53', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'UCHL5', 'USP15', 'VDR', 'WWOX', 'XPO6', 'YY1', 'ZFYVE9', 'ZMIZ1'], 'Two-hybrid': ['AATF', 'AES', 'ANK3', 'APMAP', 'APOB', 'AR', 'ATF2', 'BLZF1', 'C10ORF54', 'C14ORF105', 'CCDC33', 'CDC25A', 'CFDP1', 'CFH', 'CFLAR', 'CHRD', 'CORO1A', 'CPSF7', 'CPTP', 'CREBBP', 'CRX', 'CSH2', 'CXXC5', 'CYP11A1', 'DEDD', 'DNAJB4', 'DNAJB5', 'EBI3', 'EP300', 'EPAS1', 'FAM90A1', 'FBLN1', 'FLI1', 'FLNA', 'FOS', 'FOXH1', 'GGA1', 'GIT2', 'GMEB1', 'HDAC1', 'HEY1', 'HEYL', 'HIF1A', 'HIVEP1', 'HNRNPK', 'HOXC11', 'HP', 'ISL1', 'JUN', 'JUNB', 'KANSL1', 'KDM2A', 'KMT2B', 'LBP', 'MCM3AP', 'MEOX2', 'MTF2', 'MYC', 'MYD88', 'NCOA6', 'NEDD4', 'NEDD9', 'NR4A1', 'PAPPA', 'PARP4', 'PCDH1', 'PCK2', 'PHC2', 'PIAS4', 'PIN1', 'PLAG1', 'PLAGL1', 'PLG', 'PPP1R12C', 'PPP2R1A', 'PRDM4', 'PROX1', 'PSMB1', 'PSMD11', 'RANBP9', 'RBPMS', 'RBX1', 'RCVRN', 'RELA', 'RIOK2', 'RNF31', 'RPA1', 'RPLP0', 'SAP130', 'SBK3', 'SERTAD1', 'SETD2', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMURF1', 'SMURF2', 'SNRNP70', 'SNW1', 'SP1', 'SQSTM1', 'SS18L1', 'ST6GALNAC2', 'SVEP1', 'TANK', 'TDP2', 'TEKT4', 'TF', 'TGM2', 'TLR4', 'TMED1', 'TSC22D4', 'UBQLN4', 'USP7', 'VDR', 'WWP1', 'WWP2', 'XRCC6', 'ZBTB16', 'ZBTB3', 'ZC3H12A', 'ZCCHC14', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF329', 'ZNF774', 'ZNF83']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF6', 'ARHGEF7', 'CLASRP', 'FBXO3', 'GSC', 'MAP2K3', 'PPP2R2D', 'RAB38', 'RASD2', 'RGS3', 'RRAS2', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'WEE1', 'WWP2'], 'Affinity Capture-MS': ['ATG16L1', 'E6', 'NSP6', 'OTUB1', 'SMAD3'], 'Affinity Capture-Western': ['AXIN1', 'COL1A1', 'COL3A1', 'COL5A1', 'DDX5', 'DOK1', 'E6', 'E7', 'EP300', 'GATA4', 'GNB2L1', 'HCVGP1', 'HDAC4', 'KLF4', 'MED15', 'MELK', 'N', 'RNF111', 'SKI', 'SMAD3', 'SMAD3A', 'SMAD4', 'TGFB1I1', 'TOB1', 'TOB1A', 'TOB1B', 'VDR', 'ZEB1'], 'Co-localization': ['E7', 'N'], 'PCA': ['E6'], 'Phenotypic Enhancement': ['SMAD3A'], 'Phenotypic Suppression': ['SMAD3A'], 'Proximity Label-MS': ['M'], 'Reconstituted Complex': ['E6', 'E7', 'GATA4', 'N', 'SIN3A', 'SMAD3', 'SOX9', 'YAP1', 'ZFP128'], 'Synthetic Growth Defect': ['MMP9'], 'Two-hybrid': ['DVL1', 'E6', 'ERBB2IP', 'FOXH1', 'GATA4', 'HCVGP1', 'JUN', 'MAGI2', 'PARD3', 'SMAD3', 'ZEB2']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Large for gestational age', 'Alopecia', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Right ventricular hypertrophy', 'Myocardial fibrosis', 'Hallux valgus', 'Increased total eosinophil count', 'Acute kidney injury', 'Renal artery stenosis', 'Hypoglycemia', 'Glucose intolerance', 'Abnormal thrombosis', 'Rectal prolapse', 'Esophageal stricture', 'Pulmonary hypoplasia', 'Asthma', 'Cerebral cortical atrophy', 'Ischemic stroke', 'Aortic root aneurysm', 'Aortic dissection', 'Spontaneous pneumothorax', 'Vascular dilatation', 'Cerebral ischemia', 'Immunodeficiency', 'Systemic lupus erythematosus', 'Oral leukoplakia', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Back pain', 'Muscular dystrophy', 'Hernia of the abdominal wall', 'Cachexia', 'Ascending aortic dissection', 'Venous thrombosis', 'Ascending tubular aorta aneurysm', 'Ureteral obstruction', 'Airway obstruction', 'Pituitary prolactin cell adenoma', 'Premature ovarian insufficiency', 'Intervertebral disk degeneration', 'Lipodystrophy', 'Hamartoma', 'Chordoma', 'Stress urinary incontinence', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Urethral stricture', 'Allergy', 'Renal atrophy', 'Pulmonary bulla', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Hernia', 'Sepsis', 'Skin ulcer', 'Left ventricular dilatation', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'adolescent idiopathic scoliosis', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'gamma chain deficiency', 'seborrheic keratosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'smoking initiation', 'Staphylococcus aureus infection', 'rheumatic disease', 'lupus nephritis', 'pulse pressure measurement', 'neurodegenerative disease', 'retinal detachment', 'Autoimmune Hepatitis', 'non-high density lipoprotein cholesterol measurement', 'brain disease', 'aortic disease', 'neonatal abstinence syndrome', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'non-Hodgkins lymphoma', 'breast ductal adenocarcinoma', 'systolic blood pressure', 'diastolic blood pressure', 'pulmonary artery enlargement', 'laryngeal squamous cell carcinoma', 'cystadenocarcinoma', 'ovarian mucinous adenocarcinoma', 'smoking status measurement', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'cerebral amyloid angiopathy', 'autoimmune thyroid disease', 'stricture', 'head and neck malignant neoplasia', 'urgency urinary incontinence', 'fibrosis', 'diastolic blood pressure change measurement', 'drug use measurement', 'allergic conjunctivitis', 'aortic valve insufficiency', 'Balkan nephropathy', 'bronchiolitis obliterans', 'congenital rubella', 'coronavirus infectious disease', 'echinococcosis', 'endodermal sinus tumor', 'Gerstmann syndrome', 'Guillain-Barre syndrome', 'influenza', 'intestinal cancer', 'legionellosis', 'lymphatic system disease', 'male reproductive organ cancer', 'aneurysm-osteoarthritis syndrome', 'autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome', 'hyperuricemic nephropathy, familial juvenile type 3', 'graft versus host disease', 'autoimmune lymphoproliferative syndrome type 4', 'combined immunodeficiency due to LRBA deficiency', 'adenine phosphoribosyltransferase deficiency', 'karyomegalic interstitial nephritis', 'dyskeratosis congenita, autosomal recessive 5', 'TCR-alpha-beta-positive T-cell deficiency', 'severe combined immunodeficiency due to IKK2 deficiency', 'immunodeficiency 18', 'immunodeficiency 23', 'severe combined immunodeficiency due to CTPS1 deficiency', 'severe neurodegenerative syndrome with lipodystrophy', 'periodic fever-infantile enterocolitis-autoinflammatory syndrome', 'immunodeficiency 37', 'chronic atrial and intestinal dysrhythmia', 'DOCK2 deficiency', 'DDX41-related hematologic malignancy predisposition syndrome', 'fibrochondrogenesis 2', 'C3 glomerulonephritis', 'agammaglobulinemia 7, autosomal recessive', 'autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency', 'infantile-onset periodic fever-panniculitis-dermatosis syndrome', 'lung disease, immunodeficiency, and chromosome breakage syndrome;', 'neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade', 'chronic diarrhea due to glucoamylase deficiency', 'Bardet-Biedl syndrome', 'familial pancreatic carcinoma', 'nasopharyngeal carcinoma', 'craniosynostosis', 'keratoconus', 'common variable immunodeficiency', 'hyperplastic polyposis syndrome', 'dentin dysplasia', 'T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'qualitative or quantitative defects of dysferlin', 'holoprosencephaly', 'attenuated familial adenomatous polyposis', 'isolated agammaglobulinemia', 'pachyonychia congenita', 'familial hyperaldosteronism', 'hypohidrotic ectodermal dysplasia', 'primary ciliary dyskinesia', 'APC-related attenuated familial adenomatous polyposis', 'meningioma', 'multiple epiphyseal dysplasia', 'hemangioblastoma', 'Moyamoya disease', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'IgG4-related disease', 'juvenile polyposis syndrome', 'pituitary tumor', 'ameloblastoma', 'exstrophy-epispadias complex', 'autoimmune lymphoproliferative syndrome', 'syringomyelia', 'selective IgM deficiency', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', 'congestive heart failure', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'embryonal rhabdomyosarcoma', 'emphysema', 'epilepsy', 'fetal growth restriction', 'ganglioneuroma', 'gastric adenocarcinoma', 'esophageal adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'glioblastoma multiforme', 'hypertension', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'tuberculosis', 'glioblastoma', 'chronic granulomatous disease', 'liver mesenchymal hamartoma', 'activated PI3K-delta syndrome', 'carcinoma of liver and intrahepatic biliary tract', 'cutaneous polyarteritis nodosa', 'hereditary nonpolyposis colon cancer', 'Polymerase proofreading-related adenomatous polyposis', 'Zika virus infectious disease', 'regressive spondylometaphyseal dysplasia', 'Jeune syndrome', 'Li-Fraumeni syndrome', 'posterior cortical atrophy', '22q11.2 deletion syndrome', 'Loeys-Dietz syndrome', 'congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization', 'intrahepatic cholestasis', 'bronchopulmonary dysplasia', 'Hirschsprung disease', 'mucinous adenocarcinoma of the appendix', 'Lhermitte-Duclos disease', 'sarcoidosis', 'peeling skin syndrome', 'Fanconi anemia', 'dysspondyloenchondromatosis', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'acute liver failure', 'discoid lupus erythematosus', 'familial thoracic aortic aneurysm and aortic dissection', 'renal hypoplasia', 'renal dysplasia', 'spondyloepiphyseal dysplasia tarda', 'ulnar hemimelia', 'radial hemimelia', 'growth hormone-producing pituitary gland neoplasm', 'encephalitis', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'autosomal dominant cerebellar ataxia', 'precursor B-cell acute lymphoblastic leukemia', 'chronic graft versus host disease', 'superficial spreading melanoma', 'renal pelvis/ureter urothelial carcinoma', 'tubulointerstitial kidney disease, autosomal dominant, 2', 'lung neoplasm', 'intestinal neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'neoplasm of esophagus', 'tumor of parathyroid gland', 'polyp of colon', 'low grade glioma', 'coronary atherosclerosis', 'gram-negative bacterial infections', 'sexually transmitted disease', 'radiculitis', 'viral myocarditis', 'lip and oral cavity carcinoma', 'immunodeficiency 14b, autosomal recessive', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'respiratory tract infectious disorder', 'chondrogenic neoplasm', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'synucleinopathy', 'pulmonary sarcoidosis', 'gonorrhea', 'chronic lymphocytic leukemia', 'neoplasm of mature B-cells', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'metastatic prostate cancer', 'T-cell acute lymphoblastic leukemia', 'unspecified peripheral T-cell lymphoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'oral squamous cell carcinoma', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'adenocarcinoma', 'adenoma', 'adenosquamous lung carcinoma', 'adrenal gland pheochromocytoma', 'alveolar rhabdomyosarcoma', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', 'benign prostatic hyperplasia', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'Burkitts lymphoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'chondrosarcoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'chronic pancreatitis', 'clear cell renal carcinoma', 'endometrial carcinoma', 'renal fibrosis', 'Adenomyosis', 'immunoproliferative small intestinal disease', 'Posterior Leukoencephalopathy Syndrome', 'amyloidosis', 'neuroendocrine neoplasm', 'Spinal cord injury', 'B-cell non-Hodgkins lymphoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'intrahepatic cholangiocarcinoma', 'pharyngeal squamous cell carcinoma', 'connective tissue disease', 'pneumonitis', 'Carcinoma, Lewis Lung', 'soft tissue sarcoma', 'adult onset asthma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'renal hypertension', 'glomerular disease', 'nephritis', 'positive regulation of ovulation', 'Neurogenic bladder', 'Inguinal hernia', 'Abnormality of the urinary system', 'Renal insufficiency', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Nephrocalcinosis', 'Uterine leiomyoma', 'Cleft palate', 'Retrognathia', 'Strabismus', 'Cataract', 'Proptosis', 'Myopia', 'Pectus excavatum', 'Infertility', 'Hematuria', 'Diabetes mellitus', 'Hyperinsulinemia', 'Insulin resistance', 'Abnormality of the skeletal system', 'Osteopenia', 'Osteoporosis', 'Jaundice', 'Eczematoid dermatitis', 'Global developmental delay', 'Stroke', 'Encephalopathy', 'Parkinsonism', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Cholestasis', 'Hepatic steatosis', 'Obesity', 'ornithine carbamoyltransferase deficiency', 'pseudomyxoma peritonei', 'silicosis', 'spinal stenosis', 'BMI-adjusted waist-hip ratio', 'BMI-adjusted waist circumference', 'body fat percentage', 'balding measurement', 'liver dysplastic nodule', 'wellbeing measurement', 'insomnia measurement', 'eosinophil percentage of leukocytes', 'eosinophil percentage of granulocytes', 'BMI-adjusted hip circumference', 'calf circumference measurement', 'chronic hepatitis', 'dysplasia', 'interstitial cystitis', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'oral lichen planus', 'rhinitis', 'small cell carcinoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'Hepatobiliary Neoplasm', 'acute myocardial infarction', 'peritonitis', 'pemphigus foliaceus', 'paraneoplastic pemphigus', 'cystic kidney disease', 'ovarian dysfunction', 'Arteritis', 'Polyarteritis Nodosa', 'arteriosclerosis', 'idiopathic dilated cardiomyopathy', 'hyperuricemia', 'female reproductive endometrioid cancer', 'skin carcinoma', 'heel bone mineral density', 'marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections', 'central nervous system disease', 'sum of eosinophil and basophil counts', 'lower respiratory tract disease', 'pulmonary fibrosis', 'infarction', 'corneal disease', 'vertebral joint disease', 'aortic valve disease', 'cervical disc degenerative disorder', 'hemorrhoid', 'mitral valve disease', 'feeling nervous measurement', 'stomach disease', 'myocarditis', 'aneurysm', 'laryngeal disease', 'musculoskeletal system disease', 'Gallbladder Adenocarcinoma', 'Gallbladder Adenoma', 'Gastric Neuroendocrine Tumor G1', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Mast Cell Sarcoma', 'Nasal Cavity Polyp', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Ovarian Granulosa Cell Tumor', 'Peritoneal Multicystic Mesothelioma', 'Pituitary Gland Adenoma', 'Placental Choriocarcinoma', 'Pleural Epithelioid Mesothelioma', 'Poorly Differentiated Thyroid Gland Carcinoma', 'Rectal Tubular Adenoma', 'Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions', 'Signet Ring Cell Gastric Adenocarcinoma', 'small intestinal adenocarcinoma', 'Spinal Chordoma', 'Testicular Embryonal Carcinoma', 'Thyroid Gland Oncocytic Follicular Carcinoma', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vaginal Melanoma', 'hamartoma', 'acute respiratory distress syndrome', 'rectum cancer', 'acanthosis nigricans', 'cholesteatoma', 'Primary Pulmonary Diffuse Large B-Cell Lymphoma', 'developmental dysplasia of the hip', 'sarcopenia', 'mucous membrane pemphigoid', 'osteoarthritis, hip', 'osteoarthritis, spine', 'adrenal cortex carcinoma', 'adrenal gland hyperfunction', 'alcoholic cardiomyopathy', 'aortitis', 'atrial heart septal defect', 'causalgia', 'coronary aneurysm', 'diastolic heart failure', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'joint disease', 'lipoid nephrosis', 'mouth disease', 'multiple system atrophy', 'myeloid sarcoma', 'ocular hypertension', 'parathyroid adenoma', 'proliferative vitreoretinopathy', 'pulmonary edema', 'pulpitis', 'Raynaud disease', 'renovascular hypertension', 'rheumatic heart disease', 'Schnitzler syndrome', 'thromboangiitis obliterans', 'ulcerative proctosigmoiditis', 'uremia', 'non-alcoholic steatohepatitis', 'rotator cuff tear', 'Anemia, Hemolytic, Autoimmune', 'Cardiac Tamponade', 'End Stage Liver Disease', 'Endometritis', 'Escherichia coli Infections', 'Genital neoplasm, female', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Lentivirus Infections', 'Myocardial Ischemia', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Tularemia', 'diabetic cardiomyopathy', 'endothelial dysfunction', 'gliosarcoma', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'metastatic colorectal cancer', 'enterocolitis', 'primary biliary cirrhosis', 'abortion', 'psoriasis vulgaris', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'primary hyperoxaluria type 2', 'hyperimmunoglobulinemia D with periodic fever', 'autosomal recessive polycystic kidney disease', 'Senior-Loken syndrome 1', 'reticular dysgenesis', 'schneckenbecken dysplasia', 'combined immunodeficiency due to ZAP70 deficiency', 'familial isolated congenital asplenia', 'brachyolmia type 1, Hobaek type', 'brachyolmia type 1, toledo type', 'spondyloperipheral dysplasia', 'thoracomelic dysplasia', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'Wilson disease', 'X-linked spondyloepimetaphyseal dysplasia', 'hypoxanthine guanine phosphoribosyltransferase partial deficiency', 'Bruton-type agammaglobulinemia', 'X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia', 'combined immunodeficiency due to moesin deficiency', 'Wiskott-Aldrich syndrome', 'Aarskog-Scott syndrome, X-linked', 'hyper-IgM syndrome type 1', 'Melnick-Needles syndrome', 'Bartsocas-Papas syndrome 1', 'pulmonary venoocclusive disease', 'spondyloepimetaphyseal dysplasia, Irapa type', 'SHOX-related short stature', 'immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'spondyloepiphyseal dysplasia tarda, X-linked', 'T-B+ severe combined immunodeficiency due to JAK3 deficiency', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'skeletal dysplasia-epilepsy-short stature syndrome', 'hereditary mixed polyposis syndrome', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive', 'Ehlers-Danlos syndrome, musculocontractural type', 'spondyloepimetaphyseal dysplasia, Missouri type', 'axial spondylometaphyseal dysplasia', 'severe combined immunodeficiency due to DCLRE1C deficiency', 'spondyloepimetaphyseal dysplasia, Shohat type', 'myotonic dystrophy type 2', 'radioulnar synostosis-microcephaly-scoliosis syndrome', 'spondyloepimetaphyseal dysplasia with multiple dislocations', 'Omenn syndrome', 'xanthinuria type II', 'autoimmune lymphoproliferative syndrome type 2A', 'nephronophthisis 3', 'pyogenic arthritis-pyoderma gangrenosum-acne syndrome', 'hyper-IgM syndrome type 2', 'immunodeficiency due to CD25 deficiency', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'hyper-IgM syndrome type 3', 'multiple epiphyseal dysplasia type 5', 'anauxetic dysplasia', 'autoimmune lymphoproliferative syndrome type 2B', 'Smith-McCort dysplasia 1', 'granular corneal dystrophy type II', 'acrocapitofemoral dysplasia', 'endometrial cancer', 'hyper-IgM syndrome type 5', 'hyper-IgM syndrome type 4', 'neutrophil immunodeficiency syndrome', 'familial adenomatous polyposis 2', 'spondyloepimetaphyseal dysplasia, matrilin-3 type', 'familial avascular necrosis of femoral head', 'immunodeficiency 104', 'spondylometaphyseal dysplasia, A4 type', 'epidermolysis bullosa simplex 7, with nephropathy and deafness', 'permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome', 'mesoaxial synostotic syndactyly with phalangeal reduction', 'hyperinsulinemic hypoglycemia, familial, 4', 'Mungan syndrome', 'familial cold autoinflammatory syndrome 2', 'aortic aneurysm, familial thoracic 6', 'hypouricemia, renal, 2', 'dopa-responsive dystonia due to sepiapterin reductase deficiency', 'combined immunodeficiency due to STIM1 deficiency', 'atypical hemolytic-uremic syndrome with MCP/CD46 anomaly', 'atypical hemolytic-uremic syndrome with I factor anomaly', 'atypical hemolytic-uremic syndrome with B factor anomaly', 'atypical hemolytic-uremic syndrome with C3 anomaly', 'atypical hemolytic-uremic syndrome with thrombomodulin anomaly', 'lymphoproliferative syndrome 1', 'purine nucleoside phosphorylase deficiency', 'spondylo-megaepiphyseal-metaphyseal dysplasia', 'brachydactylous dwarfism, Mseleni type', 'spondyloepimetaphyseal dysplasia, Handigodu type', 'hemolytic anemia due to glucophosphate isomerase deficiency', 'alpha 1-antitrypsin deficiency', 'occult macular dystrophy', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'polyp', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'renal cell carcinoma', 'respiratory system disease', 'sarcoma', 'severe acute respiratory syndrome', 'Sjogren syndrome', 'skin disease', 'small cell lung carcinoma', 'rheumatoid arthritis', 'spindle cell tumor', 'spondyloarthropathy', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'systemic scleroderma', 'ulcerative colitis', 'uterine fibroid', 'melanoma', 'malignant peripheral nerve sheath tumor', 'viral disease', 'HIV infection', 'AIDS', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'temporal lobe epilepsy', 'myositis', 'leprosy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'Down syndrome', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'lung carcinoma', 'ovarian carcinoma', 'post-traumatic stress disorder', 'pulmonary arterial hypertension', 'synovial sarcoma', 'autosomal dominant polycystic liver disease', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'small intestinal neuroendocrine tumor G1', 'breast benign neoplasm', 'central nervous system primitive neuroectodermal neoplasm', 'vertebral column disorder', 'cerebral cavernous malformation', 'interstitial emphysema', 'gastric cancer', 'essential hypertension', 'hypertensive heart disease', 'familial hyperlipidemia', 'impaired renal function disease', 'myopia', 'nephrocalcinosis', 'leiomyoma', 'prolapse of female genital organ', 'brain cancer', 'nontoxic goiter', 'pure red-cell aplasia', 'crescentic glomerulonephritis', 'tuberous sclerosis', 'depressive disorder', 'ventricular septal defect', 'pneumothorax', 'Richter syndrome', 'thyroid cancer', 'giant cell tumor', 'spondylosis', 'papilloma', 'kidney cancer', 'dermatitis', 'prostatic adenoma', 'lobular neoplasia', 'gingival overgrowth', 'papillary adenocarcinoma', 'digestive system cancer', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratocarcinoma', 'teratoma', 'bone inflammation disease', 'small cell osteogenic sarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'anal canal adenocarcinoma', 'skin cancer', 'cerebellar neoplasm', 'cervical cancer', 'breast angiosarcoma', 'bile duct adenocarcinoma', 'thoracic cancer', 'colonic disorder', 'functioning pituitary gland adenoma', 'anal canal squamous cell carcinoma', 'pancreatic intraductal papillary-mucinous neoplasm', 'muscular atrophy', 'female breast carcinoma', 'retinal degeneration', 'MHC class II deficiency 4', 'immunodeficiency 122', 'inflammation', 'circulating fibrinogen levels', 'glomerular filtration rate', 'fat pad mass', 'hip circumference', 'bone tissue density', 'von Willebrand factor quality', 'waist circumference', 'age of onset of asthma', 'level of serum globulin type protein', 'red blood cell density', 'serum alanine aminotransferase amount', 'heart rate', 'age of onset of allergic disease', 'brain volume', 'serum albumin amount', 'serum creatinine amount', 'body height', 'cyst', 'X-linked hyper-IgM syndrome', 'Brachydactyly - elbow wrist dysplasia', 'Chronic mucocutaneous candidosis', 'Desbuquois syndrome', 'Chédiak-Higashi syndrome', 'Recurrent infection due to specific granule deficiency', 'Immunodeficiency syndrome with autoimmunity', 'Metaphyseal chondrodysplasia, Schmid type', 'Åland Islands eye disease', 'Ichthyosis - intellectual disability - dwarfism - renal impairment', 'Autosomal recessive early-onset inflammatory bowel disease', 'X-linked lymphoproliferative disease', 'Metaphyseal dysostosis - intellectual disability - conductive deafness', 'CHST3-related skeletal dysplasia', 'Cyclic neutropenia', 'Severe combined immunodeficiency due to adenosine deaminase deficiency', 'Aneurysm - osteoarthritis syndrome', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Multiple osteochondromas', 'Recurrent infections-myelofibrosis-nephromegaly syndrome', 'Acromesomelic dysplasia, Maroteaux type', 'Hyperlipoproteinemia type 1', 'X-linked agammaglobulinemia', 'Familial hemophagocytic lymphohistiocytosis', 'Immunodeficiency by defective expression of HLA class 2', 'Pyogenic arthritis - pyoderma gangrenosum - acne', 'Familial adenomatous polyposis', 'Thymic aplasia', 'Other metabolic disease', 'Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification', 'Hypohidrotic ectodermal dysplasia with immunodeficiency', 'Leukocyte adhesion deficiency type III', 'hematocrit', 'C-reactive protein measurement', 'glucose measurement', 'hemoglobin measurement', 'bone quantitative ultrasound measurement', 'triglyceride measurement', 'alkaline phosphatase measurement', 'creatine kinase measurement', 'cryptorchidism', 'total cholesterol measurement', 'gestational diabetes', 'low density lipoprotein cholesterol measurement', 'lymphocyte count', 'acute lung injury', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'cystatin C measurement', 'factor VII measurement', 'IGF-1 measurement', 'factor VIII measurement', 'white matter integrity', 'hip geometry', 'factor XI measurement', 'intraocular pressure measurement', 'sex hormone-binding globulin measurement', 'age at menarche', 'pelvic organ prolapse', 'FEV/FVC ratio', 'prion disease', 'aspartate aminotransferase measurement', 'protein measurement', 'neutrophil count', 'eosinophil count', 'lymph node metastatic carcinoma', 'appendicular lean mass', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'autoimmune disease', 'congenital heart disease', 'central corneal thickness', 'cholangiocarcinoma', 'reading', 'anxiety', 'primitive neuroectodermal tumor', 'aortic valve calcification', 'non-small cell lung adenocarcinoma', 'axial length measurement', 'contact dermatitis', 'vein disorder', 'in situ carcinoma', 'inborn disorder of amino acid metabolism', 'allergic asthma', 'fatty liver disease', 'alopecia', 'hypoplastic left heart syndrome', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'upper respiratory tract disorder', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'Parkinson disease', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'allergic disease', 'multiple sclerosis', 'skin basal cell carcinoma', 'childhood onset asthma', 'colorectal cancer', 'Lynch syndrome', 'Wilms tumor', 'prune belly syndrome', 'Adams-Oliver syndrome', 'Acropectorovertebral dysplasia', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency', 'Tietz syndrome', 'autosomal dominant Alport syndrome', 'Townes-Brocks syndrome', 'atelosteogenesis type III', 'Osebold-Remondini syndrome', 'brachydactyly type C', 'autosomal dominant brachyolmia', 'Gordon syndrome', 'breast cancer', 'chondrocalcinosis 2', 'congenital contractural arachnodactyly', 'fleck corneal dystrophy', 'Duane retraction syndrome', 'Leri-Weill dyschondrosteosis', 'Beckwith-Wiedemann syndrome', 'esophageal cancer', 'autoinflammatory syndrome, familial, X-linked, Behcet-like 2', 'immunodeficiency 98 with autoinflammation, X-linked', 'metastatic malignant neoplasm', 'granulomatous disease, chronic, autosomal recessive, 5', 'hyper-IgE recurrent infection syndrome 5, autosomal recessive', 'immunodeficiency 81', 'immunodeficiency 82 with systemic inflammation', 'inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive', 'immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias', 'immunodeficiency 75', 'immunodeficiency 76', 'nephrotic syndrome 16', 'immunodeficiency 69', 'immunodeficiency 78 with autoimmunity and developmental delay', 'immunodeficiency 70', 'immunodeficiency 72 with autoinflammation', 'immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia', 'autoinflammation, immune dysregulation, and eosinophilia', 'severe combined immunodeficiency due to CD70 deficiency', 'myofibroblastoma', 'invasive carcinoma', 'adenoviridae infectious disease', 'brain injury', 'nosocomial infection', 'enteritis', 'ulcer disease', 'radiation pneumonitis', 'familial adenomatous polyposis 4', 'severe combined immunodeficiency due to LAT deficiency', 'desmoplastic melanoma', 'myelofibrosis', 'salivary duct carcinoma', 'oral cavity carcinoma', 'rectal carcinoma', 'vertebral disorder', 'digestive system melanoma', 'short-rib thoracic dysplasia 17 with or without polydactyly', 'platelet abnormalities with eosinophilia and immune-mediated inflammatory disease', 'COVID-19', 'liver failure', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'spondyloepimetaphyseal dysplasia', 'gastrointestinal defects and immunodeficiency syndrome 1', 'immunodeficiency 105', 'autoinflammatory disease, X-linked', 'autoinflammatory syndrome with immunodeficiency', 'achalasia-alacrima syndrome', 'choroidal neovascularization', 'rhizomelic dysplasia, Ain-Naz type', 'autoinflammatory disease, multisystem, with immune dysregulation, X-linked', 'hyper-IgE syndrome 6, autosomal dominant, with recurrent infections', 'immunodeficiency 113 with autoimmunity and autoinflammation', 'immunodeficiency 117', 'neutropenia, severe congenital, 11, autosomal dominant', 'autoinflammation with episodic fever and immune dysregulation', 'immunodeficiency 119', 'postmenopausal osteoporosis', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'ankylosing spondylitis', 'deep vein thrombosis', 'angina pectoris', 'atherosclerosis', 'necrotizing enterocolitis', 'gastroesophageal reflux disease', 'seasonal allergic rhinitis', 'breast neoplasm', 'left ventricular hypertrophy', 'stomach neoplasm', 'obstructive sleep apnea', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'neuropathy', 'open-angle glaucoma', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Vitiligo', 'hypospadias', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'exfoliation syndrome', 'focal segmental glomerulosclerosis', 'chronic hepatitis B virus infection', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'meningococcal infection', 'membranous glomerulonephritis', 'nephrotic syndrome', 'osteonecrosis', 'bone disease', 'vascular disease', 'peripheral arterial disease', 'sclerosing cholangitis', 'scoliosis', 'brain infarction', 'thoracic aortic aneurysm', 'ventricular fibrillation', 'colonic neoplasm', 'erythrocyte count', 'platelet count', 'vital capacity', 'forced expiratory volume', 'smoking behavior', 'body weight', 'body mass index', 'body fat distribution', 'waist-hip ratio', 'corneal topography', 'neuroimaging measurement', 'metastatic neoplasm', 'wheezing', 'enthesitis-related juvenile idiopathic arthritis', 'Chronic Obstructive Asthma', 'carotid atherosclerosis', 'pulse wave reflection index measurement', 'total hip arthroplasty', 'kidney injury', 'muscle atrophy', 'chromosomal aberration frequency', 'bone metastasis', 'HMG CoA reductase inhibitor use measurement', 'Inhalant adrenergic use measurement', 'Glucocorticoid use measurement', 'low density lipoprotein triglyceride measurement', 'diverticular disease', 'corneal resistance factor', 'citrate measurement', 'cholesteryl ester measurement', 'glucuronate measurement', 'isocitrate measurement', 'atopic asthma', 'coinfection', 'total joint arthroplasty', 'aspartate aminotransferase to alanine aminotransferase ratio', 'nephrotoxicity', 'inflammatory bowel disease, immunodeficiency, and encephalopathy', 'severe malarial anemia', 'total knee arthroplasty', 'palmitate 16:0 measurement', 'sexual dimorphism measurement', 'body surface area', 'serum lipopolysaccharide activity', 'Birt-Hogg-Dube syndrome', '25-hydroxyvitamin D3 measurement', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'granulosa cell tumor', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'pulmonary tuberculosis', 'tongue squamous cell carcinoma', 'nasopharyngeal squamous cell carcinoma', 'Acute Leukemia', 'Ampulla of Vater Carcinoma', 'Appendix Adenocarcinoma', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Cavernous Hemangioma', 'Central Nervous System Lymphoma', 'Cervical Adenosquamous Carcinoma', 'cervical squamous cell carcinoma', 'Colon Dysplasia', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Endometrial Undifferentiated Carcinoma', 'Fibroblastic Neoplasm', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'nonpapillary renal cell carcinoma', 'Pallister-Hall syndrome', 'periodic fever, immunodeficiency, and thrombocytopenia syndrome', 'platyspondylic dysplasia, Torrance type', 'systemic lupus erythematosus', 'Marfan syndrome', 'melorheostosis', 'mesomelic dysplasia, Kantaputra type', 'metatropic dysplasia', 'Mobius syndrome', 'Muir-Torre syndrome', 'Cowden syndrome 1', 'myotonic dystrophy type 1', 'nail-patella syndrome', 'autosomal dominant progressive nephropathy with hypertension', 'ovarian cancer', 'Peyronie disease', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'Hutchinson-Gilford progeria syndrome', 'familial juvenile hyperuricemic nephropathy type 1', 'Peutz-Jeghers syndrome', 'prostate cancer', 'pseudoachondroplasia', 'autosomal dominant distal renal tubular acidosis', 'retinoblastoma', 'Smith-Magenis syndrome', 'spondyloepiphyseal dysplasia tarda, autosomal dominant', 'spondyloepimetaphyseal dysplasia, Strudwick type', 'spondylometaphyseal dysplasia, Kozlowski type', 'spondylometaphyseal dysplasia, Schmidt type', 'proximal symphalangism', 'syndactyly type 5', 'brachydactyly-elbow wrist dysplasia syndrome', 'tarsal-carpal coalition syndrome', 'thoracolaryngopelvic dysplasia', 'tooth and nail syndrome', 'volvulus of midgut', 'short-limb skeletal dysplasia with severe combined immunodeficiency', 'acrocallosal syndrome', 'acrodermatitis enteropathica', 'acromesomelic dysplasia 2C, Hunter-Thompson type', 'agnathia-otocephaly complex', 'autosomal recessive Alport syndrome', 'amelogenesis imperfecta type 1G', 'microphthalmia with limb anomalies', 'progressive pseudorheumatoid arthropathy of childhood', 'Bloom syndrome', 'kyphomelic dysplasia', 'lung cancer', 'heart defects-limb shortening syndrome', 'chordoma', 'Juberg-Hayward syndrome', 'Costello syndrome', 'cystic fibrosis', 'hereditary renal hypouricemia', 'diastrophic dysplasia', 'Dyggve-Melchior-Clausen disease', 'Ehlers-Danlos syndrome, dermatosparaxis type', 'multiple epiphyseal dysplasia type 4', 'classic Hodgkin lymphoma', 'immunodeficiency, common variable, 2', 'ichthyosis-intellectual disability-dwarfism-renal impairment syndrome', 'Nezelof syndrome', 'spondylometaphyseal dysplasia, Sedaghatian type', 'metaphyseal dysostosis-intellectual disability-conductive deafness syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'carnitine palmitoyl transferase II deficiency, myopathic form', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'nail-patella-like renal disease', 'nephronophthisis 1', 'congenital nephrotic syndrome, Finnish type', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'human papilloma virus infection', 'fibrosarcoma', 'benign neoplasm', 'hypertrophy', 'anaplastic astrocytoma', 'cardiac hypertrophy', 'medical procedure', 'AIDS dementia', 'juvenile idiopathic arthritis', 'insulin resistance', 'prostate intraepithelial neoplasia', 'septic peritonitis', 'vulvar intraepithelial neoplasia', 'renal carcinoma', 'thyroid carcinoma', 'metastatic melanoma', 'pancreatic carcinoma', 'rotavirus infection', 'Cutaneous T-cell lymphoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'muscular disease', 'transitional cell carcinoma of kidney', 'anaplastic large cell lymphoma', 'bacteriemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'peripheral neuropathy', 'testicular seminoma', 'pneumonia', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'refractory anemia with ringed sideroblasts', 'laryngeal neoplasm', 'lung disease', 'brain neoplasm', 'calcification', 'retinopathy', 'thyroid neoplasm'], tissue_specific_expression={'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\"small intestine Peyer's patch\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}, is_essential=False, genetic_constraint={'syn': -0.12650999426841736, 'mis': 4.360300064086914, 'lof': 0.9999799728393555}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.', '*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'breast\\\\': 0, \\\\'atrium auricular region\\\\': 1, \\\\'liver\\\\': 0, \\\\'skeletal muscle tissue\\\\': 1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\\'esophagus mucosa\\\\': 1, \\\\'macrophage\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'segmented neutrophil of bone marrow\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': -1, \\\\'class switched memory B cell\\\\': 0, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 3, \\\\'Brodmann (1909) area 9\\\\': 0, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 1, \\\\'zone of skin\\\\': 1, \\\\'leukocyte\\\\': 0, \\\\'nasopharynx\\\\': -1, \\\\'tonsil\\\\': 0, \\\\'frontal lobe\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'putamen\\\\': 0, \\\\'hematopoietic stem cell\\\\': -1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'testis\\\\': -1, \\\\'bronchus\\\\': -1, \\\\'sigmoid colon\\\\': 0, \\\\'fallopian tube\\\\': 0, \\\\'plasma cell\\\\': -1, \\\\'aorta\\\\': 0, \\\\'adrenal gland\\\\': -1, \\\\'kidney\\\\': 0, \\\\'endometrium\\\\': 0, \\\\'smooth muscle tissue\\\\': 0, \\\\'tibial artery\\\\': 0, \\\\'prefrontal cortex\\\\': 0, \\\\'CD8-positive, alpha-beta T cell\\\\': -1, \\\\'vermiform appendix\\\\': 0, \\\\'lymph node\\\\': 0, \\\\'duodenum\\\\': 0, \\\\'mature eosinophil\\\\': 0, \\\\'prostate gland\\\\': 1, \\\\'C1 segment of cervical spinal cord\\\\': -1, \\\\'lung\\\\': 0, \\\\'inflammatory macrophage\\\\': -1, \\\\'rectum\\\\': 0, \\\\'suprapubic skin\\\\': 0, \\\\'brain\\\\': -1, \\\\'coronary artery\\\\': 0, \\\\'parathyroid gland\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': 0, \\\\'esophagus muscularis mucosa\\\\': 0, \\\\'esophagus\\\\': 1, \\\\'transformed skin fibroblast\\\\': 1, \\\\'heart muscle\\\\': -1, \\\\'pancreas\\\\': 0, \\\\'uterus\\\\': 0, \\\\'placenta\\\\': 0, \\\\'seminal vesicle\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'endothelial cell of umbilical vein (resting)\\\\': 0, \\\\'minor salivary gland\\\\': 0, \\\\'endocervix\\\\': 1, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'CD8-positive, alpha-beta thymocyte\\\\': -1, \\\\'granulocyte monocyte progenitor cell\\\\': -1, \\\\'caudate nucleus\\\\': 0, \\\\'amygdala\\\\': 0, \\\\'temporal lobe\\\\': 0, \\\\'substantia nigra\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'common lymphoid progenitor\\\\': 0, \\\\'cerebral cortex\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 0, \\\\'blood\\\\': -1, \\\\'nucleus accumbens\\\\': 0, \\\\'stomach\\\\': 0, \\\\'oral mucosa\\\\': -1, \\\\'mature neutrophil\\\\': 0, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'bone marrow\\\\': -1, \\\\'gall bladder\\\\': 1, \\\\'colon\\\\': 0, \\\\'cytotoxic CD56-dim natural killer cell\\\\': -1, \\\\'pituitary gland\\\\': 0, \\\\'transverse colon\\\\': 0, \\\\'heart left ventricle\\\\': 0, \\\\'erythroblast\\\\': -1, \\\\'vagina\\\\': 1, \\\\'ovary\\\\': 1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': 1, \\\\'cerebellum\\\\': -1, \\\\'hypothalamus\\\\': -1, \\\\'common myeloid progenitor\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': -1, \\\\'alternatively activated macrophage\\\\': -1, \\\\'thyroid gland\\\\': 1, \\\\'lower leg skin\\\\': 0, \\\\'epididymis\\\\': -1, \\\\'spleen\\\\': 0, \\\\'esophagogastric junction\\\\': 0, \\\\'greater omentum\\\\': 1, \\\\'memory B cell\\\\': 0, \\\\'hippocampus proper\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': -1, \\\\'small intestine\\\\': 1, \\\\'conventional dendritic cell\\\\': -1, \\\\'cortex of kidney\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": 0, \\\\'heart\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': -1, \\\\'caudate-putamen\\\\': -1, \\\\'urinary bladder\\\\': 1, \\\\'ectocervix\\\\': 1, \\\\'regulatory T cell\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 1, \\\\'saliva-secreting gland\\\\': 0, \\\\'neutrophilic metamyelocyte\\\\': -1, \\\\'tibial nerve\\\\': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets', 'reactome_pathways'])}\\n[HumanBase] Fetching predictions for Entrez ID: 4087\\n[HumanBase] Filtering predictions with threshold: 0.7\\n[HumanBase] Filtering predictions with threshold: 0.95\\n[HumanBase] Fetching predictions for Entrez ID: 4088\\n*NAME* Summarize_GO\\n{'messages': [{'role': 'user', 'content': 'Compare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues'}], 'genes': ['SMAD2', 'SMAD3'], 'traits': [], 'proteins': [], 'drugs': [], 'transcripts': [], 'variants': {}, 'chr_pos_variants': {}, 'gene_level_gencode': {}, 'prompt': '', 'mc_setup': False, 'aa_sequences': [], 'aa_seq_result': {}, 'aa_seq_summary': '', 'gene_entities': {'SMAD2': Gene(identifiers=GeneIdentifiers(symbol='SMAD2', entrez_id='4087', uniprot_id='Q15796', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:activin responsive factor complex', 'C:chromatin', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:homomeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nucleoplasm', 'C:nucleus', 'C:protein-containing complex', 'C:transcription regulator complex', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:SMAD binding', 'F:chromatin binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:disordered domain specific binding', 'F:double-stranded DNA binding', 'F:identical protein binding', 'F:metal ion binding', 'F:phosphatase binding', 'F:tau protein binding', 'F:transforming growth factor beta receptor binding', 'F:type I transforming growth factor beta receptor binding', 'F:ubiquitin protein ligase binding', 'P:DNA-templated transcription', 'P:SMAD protein signal transduction', 'P:activin receptor signaling pathway', 'P:anatomical structure morphogenesis', 'P:anterior/posterior pattern specification', 'P:aortic valve morphogenesis', 'P:cell differentiation', 'P:cell fate commitment', 'P:cell population proliferation', 'P:determination of left/right asymmetry in lateral mesoderm', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:endocardial cushion morphogenesis', 'P:endoderm formation', 'P:gastrulation', 'P:in utero embryonic development', 'P:insulin secretion', 'P:intracellular signal transduction', 'P:lung development', 'P:mesoderm formation', 'P:negative regulation of DNA-templated transcription', 'P:negative regulation of cell differentiation', 'P:negative regulation of ossification', 'P:nodal signaling pathway', 'P:odontoblast differentiation', 'P:organ growth', 'P:pancreas development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of BMP signaling pathway', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of gene expression', 'P:positive regulation of transcription by RNA polymerase II', 'P:post-embryonic development', 'P:primary miRNA processing', 'P:pulmonary valve morphogenesis', 'P:regulation of DNA-templated transcription', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:response to cholesterol', 'P:response to glucose', 'P:secondary palate development', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:zygotic specification of dorsal/ventral axis'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma'], diseases=['Congenital heart defects, multiple types, 8, with or without heterotaxy', 'Loeys-Dietz syndrome 6'], pathways=['SMAD2/3 Phosphorylation Motif Mutants in Cancer', 'Developmental Biology', 'Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer', 'Deubiquitination', 'TGF-beta receptor signaling activates SMADs', 'Signaling by TGFB family members', 'Loss of Function of TGFBR1 in Cancer', 'Signaling by TGF-beta Receptor Complex', 'TGFBR1 KD Mutants in Cancer', 'Post-translational protein modification', 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes', 'Disease', 'Generic Transcription Pathway', 'Metabolism of proteins', 'Gene expression (Transcription)', 'Signal Transduction', 'FOXO-mediated transcription', 'Gastrulation', 'RNA Polymerase II Transcription', 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription', 'FOXO-mediated transcription of cell cycle genes', 'Loss of Function of SMAD2/3 in Cancer', 'Transcriptional regulation of pluripotent stem cells', 'SMAD4 MH2 Domain Mutants in Cancer', 'Diseases of signal transduction by growth factor receptors and second messengers', 'Formation of axial mesoderm', 'Germ layer formation at gastrulation', 'Downregulation of TGF-beta receptor signaling', 'Formation of definitive endoderm', 'Ub-specific processing proteases', 'Loss of Function of SMAD4 in Cancer', 'Downregulation of SMAD2/3:SMAD4 transcriptional activity', 'SMAD2/3 MH2 Domain Mutants in Cancer', 'Signaling by Activin', 'Signaling by TGF-beta Receptor Complex in Cancer', 'Signaling by NODAL'], cell_localizations=[], predicted_go=['regulation of production of miRNAs involved in gene silencing by miRNA', 'transmembrane receptor protein serine/threonine kinase signaling pathway', 'positive regulation of transcription from RNA polymerase II promoter in response to stress', 'negative regulation of MAPK cascade', 'negative regulation of protein phosphorylation', 'negative regulation of protein modification process', 'regulation of transcription from RNA polymerase II promoter in response to stress', 'negative regulation of DNA binding transcription factor activity', 'positive regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of phosphorylation', 'regulation of kidney development', 'regulation of epidermis development', 'positive regulation of protein modification by small protein conjugation or removal', 'I-kappaB kinase/NF-kappaB signaling', 'regulation of transforming growth factor beta2 production', 'nodal signaling pathway', 'transforming growth factor beta receptor signaling pathway', 'gene silencing by miRNA', 'regulation of pathway-restricted SMAD protein phosphorylation', 'negative regulation of activin receptor signaling pathway', 'regulation of SMAD protein signal transduction', 'negative regulation of pathway-restricted SMAD protein phosphorylation', 'regulation of gene silencing by miRNA', 'negative regulation of cellular response to growth factor stimulus', 'regulation of epidermal cell differentiation', 'proteasomal protein catabolic process', 'regulation of production of small RNA involved in gene silencing by RNA', 'cellular response to transforming growth factor beta stimulus', 'positive regulation of protein catabolic process', 'regulation of protein modification by small protein conjugation or removal', 'positive regulation of MAPK cascade', 'regulation of DNA-templated transcription in response to stress', 'positive regulation of I-kappaB kinase/NF-kappaB signaling', 'negative regulation of fat cell differentiation', 'pathway-restricted SMAD protein phosphorylation', 'negative regulation of cell proliferation', 'regulation of transforming growth factor beta receptor signaling pathway', 'cellular response to BMP stimulus', 'regulation of cellular response to transforming growth factor beta stimulus', 'regulation of DNA binding transcription factor activity', 'regulation of BMP signaling pathway', 'negative regulation of intracellular signal transduction', 'regulation of posttranscriptional gene silencing', 'activation of MAPKK activity', 'negative regulation of transcription by competitive promoter binding', 'response to BMP', 'regulation of protein ubiquitination', 'histone modification', 'regulation of gene silencing by RNA', 'BMP signaling pathway', 'stress-activated MAPK cascade', 'positive regulation of SMAD protein signal transduction', 'response to transforming growth factor beta', 'regulation of vasculature development', 'positive regulation of epidermal cell differentiation', 'negative regulation of androgen receptor signaling pathway', 'SMAD protein signal transduction', 'negative regulation of myosin-light-chain-phosphatase activity', 'positive regulation of DNA binding transcription factor activity', 'regulation of angiogenesis', 'regulation of cellular response to growth factor stimulus', 'regulation of transmembrane receptor protein serine/threonine kinase signaling pathway', 'regulation of keratinocyte differentiation', 'activin receptor signaling pathway', 'regulation of epithelial cell differentiation', 'positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway', 'positive regulation of proteasomal ubiquitin-dependent protein catabolic process', 'regulation of stress-activated MAPK cascade', 'negative regulation of BMP signaling pathway', 'positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus', 'SMAD protein complex assembly'], predicted_disease=['aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709)']), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['SMAD3', 'SMAD4', 'SMURF2'], 'Affinity Capture-MS': ['ARID1A', 'ARID1B', 'ASH2L', 'ATAD3B', 'BCL7A', 'BTBD9', 'BUB3', 'C1ORF116', 'CAD', 'CCT6A', 'CDC27', 'CGA', 'CPSF7', 'CREBBP', 'CSNK1D', 'CTNNB1', 'CUL4A', 'CUL4B', 'DCAF7', 'DDX3Y', 'DGKA', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'EPB41L5', 'ERBB2IP', 'EZH2', 'FAM83G', 'FLOT1', 'FLOT2', 'FYN', 'GSK3A', 'GTF3C2', 'GTF3C6', 'HCFC1', 'HDAC2', 'HDAC4', 'HINT3', 'HSPA4', 'ITGB4', 'KLF5', 'KMT2C', 'LDLRAD4', 'LEMD3', 'MED15', 'MED16', 'MED17', 'MED19', 'MED20', 'MED22', 'MED25', 'MED31', 'MED4', 'MED9', 'MEN1', 'MTMR4', 'NCOA3', 'OGT', 'OPA1', 'OTUB1', 'PARK2', 'PCBP1', 'PCID2', 'PLEKHA4', 'PSPC1', 'RIN1', 'SGSH', 'SIK3', 'SKI', 'SKIL', 'SLC25A3', 'SLC25A5', 'SLC25A6', 'SMAD1', 'SMAD3', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMARCD2', 'SMPDL3B', 'SMURF2', 'SNW1', 'SNX27', 'SQRDL', 'TAF1', 'TAF2', 'TAF3', 'TAF5', 'TAF6', 'TMED8', 'TMOD1', 'TRIM28', 'TRIM33', 'TRIM67', 'U2AF2', 'WDR82', 'WRNIP1', 'WWP2', 'YAF2', 'YY1', 'ZFYVE9'], 'Affinity Capture-RNA': ['DDX58', 'ELAVL1'], 'Affinity Capture-Western': ['ACVR1B', 'ACVR2B', 'AKT1', 'ANAPC10', 'ATF3', 'BRCA2', 'CDC16', 'CDC27', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DAB2', 'DOCK9', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'ETV4', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'FOXP1', 'GLI1', 'GTF2I', 'GTF2IRD1', 'HDAC1', 'HGS', 'HYAL2', 'ING2', 'INSR', 'IRF3', 'IRF7', 'ITCH', 'JUN', 'KAT2A', 'KAT2B', 'KDM6B', 'KLF5', 'LEF1', 'MAPT', 'MED15', 'MED24', 'MED6', 'MEF2A', 'METTL14', 'METTL3', 'MYC', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFYC', 'NOTCH4', 'NUP214', 'OTUB1', 'OVOL2', 'PIAS3', 'PIAS4', 'PIN1', 'PML', 'PRDM16', 'RBBP5', 'RELB', 'RGCC', 'RNF111', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD6', 'SMAD7', 'SMARCA4', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'STRAP', 'TCF12', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TP53', 'TRIM28', 'TRIM33', 'TSC2', 'UCHL1', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWP1', 'WWP2', 'YAP1', 'ZEB1', 'ZFYVE9'], 'Biochemical Activity': ['ACVR1B', 'CAMK2G', 'CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'ITCH', 'TGFBR1'], 'Co-crystal Structure': ['SMAD4'], 'Co-fractionation': ['AP1M1', 'ARID1B', 'CAV1', 'CREBBP', 'CTNNB1', 'HDAC1', 'HMGA2', 'MTA2', 'NAA15', 'NCOA3', 'PARP1', 'PML', 'PRKDC', 'RBM14', 'RELA', 'SMAD3', 'SMAD4', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SUB1', 'TGFBR1', 'TRIM33', 'XRCC6', 'ZFYVE9'], 'Co-localization': ['CAMK2A', 'TGFBR1', 'TP53'], 'FRET': ['BECN1', 'LATS2', 'MYC', 'SMAD1'], 'Phenotypic Enhancement': ['SMAD3', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['SPPL3'], 'Proximity Label-MS': ['CCNF', 'EPHA2', 'OPTN', 'RAB7A', 'SNCA', 'TGOLN2'], 'Reconstituted Complex': ['ANAPC10', 'ANP32B', 'ANP32E', 'ATP5I', 'BPTF', 'CREBBP', 'DAB2', 'DVL1', 'ELAC2', 'ERBB2IP', 'ESR1', 'FHL1', 'FHL2', 'FHL3', 'FOXH1', 'HDAC2', 'HIPK2', 'HYAL2', 'INSR', 'IRF7', 'JUN', 'KAT2B', 'LCK', 'LEF1', 'MECOM', 'MEF2A', 'MEF2C', 'MYC', 'MYOCD', 'NEDD4L', 'NEFM', 'NFIA', 'NUP214', 'OTUB1', 'PARD3', 'PIAS3', 'PIK3CA', 'PIN1', 'PTMS', 'RHOA', 'SH2D2A', 'SKI', 'SMAD4', 'SMAD7', 'SMURF2', 'SNW1', 'SOD1', 'SP1', 'STUB1', 'SYT1', 'TP53', 'TUBA1B', 'UCHL5', 'YY1', 'ZFYVE9'], 'Two-hybrid': ['ABTB1', 'AKT1', 'ANAPC2', 'ANK3', 'ANTXR2', 'BAZ1A', 'BTBD2', 'C22ORF46', 'C9ORF156', 'CISH', 'COPS5', 'CORO2A', 'CREBBP', 'CSH1', 'CSH2', 'CUL5', 'CYLC2', 'CYP11A1', 'DCUN1D1', 'DNAJB5', 'DNAJC7', 'DOCK8', 'DYNC1H1', 'DYRK1A', 'EEF1A1', 'EIF3L', 'EP300', 'ETV4', 'FAM161B', 'FBP2', 'FOXH1', 'GATAD2B', 'GFER', 'HSD17B3', 'INSR', 'KHDRBS1', 'KIAA1033', 'KPNB1', 'LAMA5', 'LEMD3', 'MAP2K1', 'MLLT4', 'MYC', 'NAGK', 'NCOA6', 'NEDD4L', 'OS9', 'PAPOLA', 'PAPPA', 'PAXIP1', 'PEX19', 'PIAS4', 'PLIN3', 'POU2AF1', 'PPP2R1A', 'PRKAR1A', 'PSAP', 'PSG9', 'PSMD11', 'PSMD8', 'RANBP6', 'RANBP9', 'RARB', 'RASA1', 'RNF123', 'RNPC3', 'ROCK1', 'RPS14', 'RPS27A', 'RXRA', 'SKI', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD9', 'SMURF1', 'SMURF2', 'SNAPIN', 'SNIP1', 'SNRNP70', 'SNW1', 'SP1', 'SRI', 'ST13', 'ST5', 'TBC1D1', 'TGIF1', 'TGM2', 'TRIM62', 'UBA52', 'UBR5', 'XPA', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF41', 'ZNF510', 'ZNHIT6']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF1', 'ARHGEF6', 'ARHGEF7', 'ARL4D', 'CDC40', 'FBXO3', 'IRAK2', 'LHX9', 'LMO2', 'MAP2K3', 'NUAK2', 'PPP2R2D', 'RAB34', 'RAB38', 'RASD2', 'RGS3', 'RHEBL1', 'RHOBTB1', 'RHOD', 'RHOJ', 'RPS27A', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'UHMK1', 'WWP2'], 'Affinity Capture-MS': ['ALDH4A1', 'BACH1', 'E6', 'FANCD2', 'NSP16AB', 'OTUB1', 'PAXIP1', 'RUNX1'], 'Affinity Capture-Western': ['COL1A1', 'COL3A1', 'COL5A1', 'DOK1', 'E6', 'E7', 'GATA4', 'HCVGP1', 'KAP-ALPHA3', 'KLF4', 'LEF1', 'MED', 'MED15', 'MEF2A', 'RNF111', 'SKI', 'SMAD2', 'SMAD4', 'SMOX', 'SNOO', 'UBX', 'VIS', 'WWTR1', 'YAP1'], 'Co-localization': ['E7', 'EZH2-A', 'KLF4'], 'PCA': ['E6', 'SMOX'], 'Phenotypic Enhancement': ['BABO', 'INR', 'SMOX', 'YKI'], 'Phenotypic Suppression': ['BABO', 'HPO', 'INR', 'MYO', 'PLUM', 'PTEN', 'SCGDELTA', 'SMOX'], 'Reconstituted Complex': ['E7', 'LEMD3', 'SMAD2', 'SOX9', 'UBX', 'ZFP128'], 'Two-hybrid': ['CG18095', 'D', 'E6', 'EG', 'FOXH1', 'HOXA13', 'HOXD13', 'HR78', 'SMAD2', 'SMOX', 'UBX', 'ZEB2', 'ZEN']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_PI3K_AKT_MTOR_SIGNALING'], 'C1': ['chr18q21'], 'C2': ['SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN', 'KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'RAMALHO_STEMNESS_UP', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'WP_TH17_CELL_DIFFERENTIATION_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'WP_IL26_SIGNALING', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'BENPORATH_PROLIFERATION', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'REACTOME_SIGNALING_BY_NODAL', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'WP_CELL_CYCLE', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'REACTOME_DEUBIQUITINATION', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'HOSHIDA_LIVER_CANCER_SUBCLASS_S1', 'WP_HIPPO_SIGNALING_REGULATION', 'PID_MYC_REPRESS_PATHWAY', 'WP_INTEGRATED_BREAST_CANCER_PATHWAY', 'BLALOCK_ALZHEIMERS_DISEASE_UP', 'POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'YOSHIMURA_MAPK8_TARGETS_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'WP_INTEGRATED_CANCER_PATHWAY', 'HOUNKPE_HOUSEKEEPING_GENES', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'PID_GLYPICAN_1PATHWAY', 'BIOCARTA_TGFB_PATHWAY', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'ZAMORA_NOS2_TARGETS_UP', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'WP_TGFB_SMAD_SIGNALING', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'HORIUCHI_WTAP_TARGETS_DN', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'WP_TGIF_DISRUPTION_OF_SHH_SIGNALING', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'BORCZUK_MALIGNANT_MESOTHELIOMA_UP', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'PUJANA_ATM_PCC_NETWORK', 'TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'PUJANA_BRCA1_PCC_NETWORK', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'PULVER_FOREY_CELLCYCLE_PEAKING_S2', 'DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING', 'PID_TGFBR_PATHWAY', 'REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'KEGG_COLORECTAL_CANCER', 'REACTOME_SIGNALING_BY_ACTIVIN', 'SHEN_SMARCA2_TARGETS_UP', 'FAELT_B_CLL_WITH_VH3_21_DN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS', 'BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP'], 'C3': ['MIR95_5P', 'MIR302D_5P', 'MIR216A_3P', 'MIR3913_5P', 'MIR522_3P', 'GATTGGY_NFY_Q6_01', 'MIR7159_5P', 'MIR374B_5P', 'MIR3671', 'MIR6716_5P', 'MYCMAX_02', 'MIR3184_3P', 'KLF7_TARGET_GENES', 'MIR524_5P', 'MIR223_5P', 'NFY_Q6', 'MIR450A_1_3P', 'ZSCAN30_TARGET_GENES', 'MIR4773', 'MIR624_3P', 'MIR224_3P', 'MIR498_3P', 'MIR409_3P', 'MIR3942_3P', 'NFY_C', 'POU2AF1_TARGET_GENES', 'MIR3714', 'MIR8485', 'MIR6868_3P', 'MIR3065_5P', 'MIR1264', 'MIR9500', 'MIR155_5P', 'ZNF423_TARGET_GENES', 'MIR340_5P', 'MIR548AG', 'MIR5584_5P', 'MIR4422', 'MIR8085', 'MIR30A_3P', 'MIR497_3P', 'MIR6074', 'MIR208A_5P', 'MIR4298', 'MIR6134', 'MIR365B_5P', 'NFY_Q6_01', 'AHRR_TARGET_GENES', 'MIR6878_5P', 'MIR4761_5P', 'AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D', 'MIR5590_3P', 'MIR103A_1_5P', 'MIR4305', 'MIR365A_5P', 'MIR1302', 'ZNF592_TARGET_GENES', 'MAX_01', 'MIR374A_5P', 'MIR769_5P', 'MIR4496', 'MIR30E_3P', 'ZNF282_TARGET_GENES', 'CAGCACT_MIR5123P', 'TOP2B_TARGET_GENES', 'MIR5002_5P', 'MIR656_3P', 'MIR302A_5P', 'MYCMAX_01', 'MIR520E_5P', 'MIR374B_3P', 'MIR551B_5P', 'HMX1_01', 'MIR30D_3P', 'MIR12124', 'NFY_01', 'MIR4799_5P', 'GGTGTGT_MIR329', 'MIR607', 'GGGTGGRR_PAX4_03', 'MIR4724_3P', 'ZNF407_TARGET_GENES', 'MIR520D_5P', 'MIR548AI_MIR570_5P', 'AACTTT_UNKNOWN', 'MIR302B_5P', 'MIR4735_3P', 'CCAATNNSNNNGCG_UNKNOWN', 'MIR18A_5P_MIR18B_5P', 'MIR103A_2_5P', 'MIR548BA', 'MIR1910_3P', 'MIR34C_3P', 'MIR3121_3P', 'MIR142_5P', 'MIR3122', 'MIR128_3P', 'GCTNWTTGK_UNKNOWN', 'CEBPZ_TARGET_GENES', 'SMARCA1_TARGET_GENES', 'GCACCTT_MIR18A_MIR18B', 'MIR3913_3P', 'MIR190B_3P', 'ALPHACP1_01', 'MIR4719', 'MIR3692_5P', 'MIR1237_3P', 'MIR5692B_MIR5692C', 'MIR5004_5P', 'MIR767_3P', 'ZNF549_TARGET_GENES', 'CACGTG_MYC_Q2', 'MIR6511A_5P', 'MIR12136', 'MIR3919', 'MIR3679_3P', 'MIR93_3P', 'MIR4272', 'MIR6731_5P', 'MIR208B_5P', 'MIR6792_5P'], 'C4': ['GCM_UBE2N', 'MORF_PPP2R5E', 'MORF_BECN1', 'MORF_PRKAG1', 'MORF_RAB1A', 'MORF_UBE2A', 'MORF_TERF2IP', 'MORF_DDB1', 'MORF_SS18', 'MORF_TPR', 'GCM_MAX', 'GCM_DFFA', 'GCM_ZNF198', 'MORF_RAB11A'], 'C6': ['SNF5_DN.V1_UP'], 'C7': ['GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP', 'GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN', 'GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN', 'GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN', 'GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP', 'GSE36009_UNSTIM_VS_LPS_STIM_DC_DN', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN', 'GSE339_CD4POS_VS_CD8POS_DC_DN', 'GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN', 'GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP', 'GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP', 'GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP', 'GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN', 'GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP', 'GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP', 'GSE27786_LIN_NEG_VS_CD4_TCELL_DN', 'GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN', 'GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN', 'GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN', 'GSE17721_LPS_VS_CPG_6H_BMDC_UP', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP', 'GSE22886_IL2_VS_IL15_STIM_NKCELL_DN', 'GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN', 'GSE17721_12H_VS_24H_POLYIC_BMDC_UP', 'GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN', 'GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP', 'GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN', 'GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN', 'GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP', 'GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP', 'GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP', 'GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP', 'GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN', 'GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP', 'GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN', 'GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN', 'GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN', 'GSE17721_12H_VS_24H_CPG_BMDC_UP', 'GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN', 'GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN', 'GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP', 'GSE11818_WT_VS_DICER_KO_TREG_DN', 'GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP', 'GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP', 'GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP', 'GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP', 'GSE17721_POLYIC_VS_CPG_4H_BMDC_DN', 'GSE22886_TH1_VS_TH2_48H_ACT_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN', 'GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP', 'GSE27786_NKTCELL_VS_MONO_MAC_DN', 'GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN', 'GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN', 'GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP', 'GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN', 'GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP', 'GSE17721_LPS_VS_CPG_24H_BMDC_DN', 'GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP'], 'C8': []}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Overgrowth', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Myocardial fibrosis', 'Increased total eosinophil count', 'Thrombocytosis', 'Anemia', 'Acute kidney injury', 'Glucose intolerance', 'Pulmonary hypoplasia', 'Pneumonia', 'Asthma', 'Ischemic stroke', 'Cerebral ischemia', 'Vascular dilatation', 'Aortic dissection', 'Systemic lupus erythematosus', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Skeletal muscle atrophy', 'Muscular dystrophy', 'Cachexia', 'Thrombophlebitis', 'Miscarriage', 'Ureteral obstruction', 'Airway obstruction', 'Amyotrophic lateral sclerosis', 'Peripheral demyelination', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Reduced sperm motility', 'Urethral stricture', 'Renal atrophy', 'Cervical polyp', 'Shock', 'Granuloma', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Sepsis', 'geleophysic dysplasia', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'hydronephrosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'renal cell adenocarcinoma', 'Autoimmune Hepatitis', 'neurodegenerative disease', 'brain disease', 'aortic disease', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'head and neck neoplasia', 'breast ductal adenocarcinoma', 'laryngeal squamous cell carcinoma', 'ovarian adenocarcinoma', 'ovarian mucinous adenocarcinoma', 'ovarian teratoma', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'dysplastic oral keratinocyte', 'undifferentiated carcinoma', 'cerebral amyloid angiopathy', 'head and neck malignant neoplasia', 'breastfeeding duration', 'urgency urinary incontinence', 'fibrosis', 'Balkan nephropathy', 'congenital rubella', 'echinococcosis', 'Gerstmann syndrome', 'inclusion body myositis', 'muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10', 'severe neurodegenerative syndrome with lipodystrophy', 'Diamond-Blackfan anemia', 'cardiofaciocutaneous syndrome', 'adrenomyeloneuropathy', 'hereditary sensory and autonomic neuropathy', 'nasopharyngeal carcinoma', 'keratoconus', 'dentin dysplasia', 'T-cell non-Hodgkin lymphoma', 'dyskeratosis congenita', 'pneumoconiosis', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'cryopyrin-associated periodic syndrome', 'holoprosencephaly', 'pachyonychia congenita', 'familial rhabdoid tumor', 'familial hyperaldosteronism', 'primary ciliary dyskinesia', 'meningioma', 'pilocytic astrocytoma', 'hemangioblastoma', 'microcephaly-brain defect-spasticity-hypernatremia syndrome', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'heritable pulmonary arterial hypertension', 'juvenile polyposis syndrome', 'congenital herpes simplex virus infection', 'popliteal pterygium syndrome', 'ameloblastoma', 'hypersensitivity pneumonitis', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'emphysema', 'epilepsy', 'esophageal adenocarcinoma', 'fetal growth restriction', 'follicular thyroid adenoma', 'ganglioneuroma', 'follicular thyroid carcinoma', 'gastric adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'genetic disorder', 'germ cell tumor', 'glioblastoma multiforme', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'large cell neuroendocrine carcinoma', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'neural tube defect', 'tuberculosis', 'glioblastoma', 'carcinoma of liver and intrahepatic biliary tract', 'hereditary nonpolyposis colon cancer', 'Zika virus infectious disease', 'left ventricular noncompaction', 'multiminicore myopathy', 'Loeys-Dietz syndrome', 'neurofibromatosis type 1', 'Leber congenital amaurosis', 'osteogenesis imperfecta', 'progressive supranuclear palsy', 'intrahepatic cholestasis', 'lymphedema', 'posterior cortical atrophy', 'follicular lymphoma', 'kidney Wilms tumor', 'bronchopulmonary dysplasia', 'sarcoidosis', 'peeling skin syndrome', 'lissencephaly with cerebellar hypoplasia', 'aggressive NK-cell leukemia', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'familial thoracic aortic aneurysm and aortic dissection', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'precursor B-cell acute lymphoblastic leukemia', 'superficial spreading melanoma', 'lung neoplasm', 'intestinal neoplasm', 'odontogenic neoplasm', 'disorder of ear', 'endometrium neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'carcinoma of pharynx', 'polyp of colon', 'low grade glioma', 'corticobasal degeneration disorder', 'cervical intraepithelial neoplasia', 'viral myocarditis', 'lip and oral cavity carcinoma', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'chondrogenic neoplasm', 'intraepithelial neoplasia', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'pulmonary sarcoidosis', 'gonorrhea', 'B-cell acute lymphoblastic leukemia', 'chronic lymphocytic leukemia', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'myelodysplastic syndrome', 'oral squamous cell carcinoma', 'gastritis', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'acute promyelocytic leukemia', 'adenocarcinoma', 'adenoma', 'age', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', \\\"Barrett's esophagus\\\", 'benign prostatic hyperplasia', 'bladder tumor', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'central nervous system cancer', 'chondrosarcoma', 'chromophobe renal cell carcinoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'clear cell renal carcinoma', 'endometrial carcinoma', 'ovarian serous carcinoma', 'renal fibrosis', 'Abruptio Placentae', 'Adenomyosis', 'Carcinoma, Lewis Lung', 'chronic myelomonocytic leukemia', 'Marchiafava-Bignami Disease', 'oral submucous fibrosis', 'osteoradionecrosis', 'renal nutcracker syndrome', 'amyloidosis', 'mucositis', 'neuroendocrine neoplasm', 'neuromuscular disease', 'oral mucositis', 'Spinal cord injury', 'cutaneous squamous cell carcinoma', 'Barrett adenocarcinoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'pharyngeal squamous cell carcinoma', 'soft tissue sarcoma', 'undifferentiated pleomorphic sarcoma', 'connective tissue disease', 'pneumonitis', 'intrahepatic cholangiocarcinoma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'glomerular disease', 'nephritis', 'Neurogenic bladder', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Uterine leiomyoma', 'Cleft palate', 'Hydrocephalus', 'Cataract', 'Myopia', 'Autism', 'Infertility', 'Diabetes mellitus', 'Insulin resistance', 'Osteoporosis', 'Hyperkeratosis', 'Intellectual disability', 'Ataxia', 'Mental deterioration', 'Stroke', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Hepatic steatosis', 'Obesity', 'mixed connective tissue disease', 'pneumocystosis', 'pseudomyxoma peritonei', 'silicosis', 'toxoplasmosis', 'hemoglobin A1 measurement', 'BMI-adjusted waist-hip ratio', 'liver dysplastic nodule', 'gut microbiome measurement', 'platelet crit', 'allergen exposure measurement', 'calf circumference measurement', 'dysplasia', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'digestive system neoplasm', 'Hepatobiliary Neoplasm', 'American trypanosomiasis', 'acute myocardial infarction', 'pemphigus foliaceus', 'cystic kidney disease', 'Polycystic Kidney Disease', 'arteriosclerosis', 'hyperuricemia', 'skin carcinoma', 'heel bone mineral density', 'pulmonary fibrosis', 'hyperaldosteronism', 'gastric ulcer', 'infarction', 'aortic valve disease', 'heart valve disease', 'mitral valve disease', 'urinary tract obstruction', 'prostate disease', 'stomach disease', 'myocarditis', 'aneurysm', 'enthesopathy', 'musculoskeletal system disease', 'metastasis', 'Gallbladder Adenocarcinoma', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Malignant Mesothelioma', 'Malignant Pancreatic Neoplasm', 'Medullomyoblastoma with Myogenic Differentiation', 'Microcystic Meningioma', 'Mixed Tumor of the Salivary Gland', 'Nasal Cavity Polyp', 'Osteoblastoma', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Paraganglioma', 'Placental Choriocarcinoma', 'Rectal Tubular Adenoma', 'Sarcomatoid Carcinoma', 'Signet Ring Cell Gastric Adenocarcinoma', 'Synovial Chondromatosis', 'Testicular Non-Seminomatous Germ Cell Tumor', 'Testicular Yolk Sac Tumor', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vulvar Squamous Cell Carcinoma', 'acute respiratory distress syndrome', 'sarcopenia', 'rectum cancer', 'acanthosis nigricans', 'mucous membrane pemphigoid', 'punctate palmoplantar keratoderma type III', 'adrenal cortex carcinoma', 'alcoholic liver cirrhosis', 'atrophic gastritis', 'dental fluorosis', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'multiple system atrophy', 'myeloid sarcoma', 'nodular goiter', 'periapical granuloma', 'pulmonary edema', 'renovascular hypertension', 'retinopathy of prematurity', 'rheumatic heart disease', 'thromboangiitis obliterans', 'tooth disease', 'uremia', 'non-alcoholic steatohepatitis', 'Cryptogenic Organizing Pneumonia', 'Fascioliasis', 'Follicular Cyst', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Myocardial Ischemia', 'Pelvic Inflammatory Disease', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Pneumonia, Aspiration', 'Respiratory Syncytial Virus Infection', 'diabetic cardiomyopathy', 'diabetic foot', 'endothelial dysfunction', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'schistosomiasis', 'abortion', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'Bartsocas-Papas syndrome 1', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'SHOX-related short stature', 'intellectual disability, X-linked syndromic, Turner type', 'Fabry disease', 'X-linked corneal dermoid', 'Aarskog-Scott syndrome, X-linked', 'holoprosencephaly-hypokinesia-congenital contractures syndrome', 'Melnick-Needles syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'Wilson disease', 'adenomyosis', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'Ehlers-Danlos syndrome, musculocontractural type', 'tetrasomy 12p', 'sickle cell anemia', 'hypotonia-cystinuria syndrome', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'autoimmune lymphoproliferative syndrome type 2B', 'endometrial cancer', 'Loeys-Dietz syndrome 1', 'hyperinsulinemic hypoglycemia, familial, 4', 'preterm premature rupture of the membranes', 'Mungan syndrome', 'Crouzon syndrome-acanthosis nigricans syndrome', 'papillary renal cell carcinoma', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'pterygium', 'renal cell carcinoma', 'rheumatoid arthritis', 'sarcoma', 'severe acute respiratory syndrome', 'small cell lung carcinoma', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'spondyloarthropathy', 'stroke', 'subarachnoid hemorrhage', 'systemic scleroderma', 'ulcerative colitis', 'melanoma', 'hepatocellular adenoma', 'viral disease', 'HIV infection', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'pneumococcal infection', 'temporal lobe epilepsy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'malaria', 'folate deficiency', 'lung carcinoma', 'ovarian carcinoma', 'familial amyotrophic lateral sclerosis', 'pulmonary arterial hypertension', 'age-related macular degeneration', 'synovial sarcoma', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'villous adenoma', 'mucosal melanoma', 'ovarian clear cell cancer', 'central nervous system primitive neuroectodermal neoplasm', 'Crohn ileitis', 'vertebral column disorder', 'endometrial disorder', 'gastric cancer', 'penile cancer', 'myopia', 'pulmonary alveolar proteinosis', 'Chagas disease', 'leiomyoma', 'brain cancer', 'tuberous sclerosis', 'sick sinus syndrome', 'arteriovenous hemangioma/malformation', 'hypertensive heart disease', 'head and neck carcinoma', 'depressive disorder', 'pneumothorax', 'Richter syndrome', 'peritoneum cancer', 'thyroid cancer', 'disorder of sexual differentiation', 'vulvar melanoma', 'papilloma', 'rectosigmoid junction neoplasm', 'Treacher-Collins syndrome', 'prostatic acinar adenocarcinoma', 'gingival overgrowth', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratoma', 'bone inflammation disease', 'extraosseous osteosarcoma', 'chondroblastic osteosarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'lung benign neoplasm', 'skin cancer', 'cervical cancer', 'seminoma', 'breast angiosarcoma', 'cerebellar pilocytic astrocytoma', 'salivary gland adenoid cystic carcinoma', 'bile duct adenocarcinoma', 'gastroesophageal junction adenocarcinoma', 'thoracic cancer', 'acral lentiginous melanoma', 'endometrial mixed adenocarcinoma', 'female breast carcinoma', 'inflammation', 'erythrocyte volume', 'glomerular filtration rate', 'bone tissue density', 'progesterone amount', 'serum alanine aminotransferase amount', 'serum urea amount', 'serum creatinine amount', 'body height', 'cyst', 'Hypotonia - cystinuria syndrome', 'Chédiak-Higashi syndrome', 'Åland Islands eye disease', 'Hydrocephalus with stenosis of the aqueduct of Sylvius', 'Autoimmune lymphoproliferative syndrome with recurrent viral infections', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Persistent Müllerian duct syndrome', 'WHIM syndrome', 'Familial adenomatous polyposis', 'Other metabolic disease', 'hematocrit', 'C-reactive protein measurement', 'hematological measurement', 'alkaline phosphatase measurement', 'cryptorchidism', 'lymphocyte count', 'gestational diabetes', 'acute lung injury', 'serum gamma-glutamyl transferase measurement', 'HbA1c measurement', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'wet macular degeneration', 'insomnia', 'hypothyroidism', 'pelvic organ prolapse', 'metabolite measurement', 'eosinophil count', 'lymph node metastatic carcinoma', 'embryonal carcinoma', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'monocyte count', 'autoimmune disease', 'congenital heart disease', 'cholangiocarcinoma', 'human african trypanosomiasis', 'reading', 'congenital heart malformation', 'temporomandibular joint disorder', 'axial length measurement', 'myeloid leukemia', 'lupus erythematosus', 'allergic asthma', 'fatty liver disease', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'cataract', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'multiple sclerosis', 'skin basal cell carcinoma', 'brain glioma', 'colorectal cancer', 'Wilms tumor', 'Townes-Brocks syndrome', 'nevoid basal cell carcinoma syndrome', 'breast cancer', 'congenital contractural arachnodactyly', 'Duane retraction syndrome', 'dyschromatosis symmetrica hereditaria', 'metastatic malignant neoplasm', 'Loeys-Dietz syndrome 6', 'cervical squamous intraepithelial neoplasia', 'leukoplakia', 'spinal cord injury', 'ulcer disease', 'desmoplastic melanoma', 'myelofibrosis', 'oral cavity carcinoma', 'rectal carcinoma', 'hydrocephalus, congenital, 3, with brain anomalies', 'nasal cavity and paranasal sinus carcinoma', 'COVID-19', 'Dravet syndrome', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'achalasia-alacrima syndrome', 'metabolic bone disorder', 'congenital heart defects, multiple types, 8, with or without heterotaxy', 'postmenopausal osteoporosis', 'intestinal polyp', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'breast neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'stomach neoplasm', 'ankylosing spondylitis', 'ciliopathy', 'deep vein thrombosis', 'obstructive sleep apnea', 'necrotizing enterocolitis', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'atherosclerosis', 'open-angle glaucoma', 'androgenetic alopecia', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'focal segmental glomerulosclerosis', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'myeloproliferative disorder', 'nephrotic syndrome', 'vascular disease', 'thoracic aortic aneurysm', 'venous thromboembolism', 'platelet count', 'body mass index', 'neuroimaging measurement', 'metastatic neoplasm', 'whole body water mass', 'kidney injury', 'bone metastasis', 'gastrointestinal disease', 'aspartate aminotransferase to alanine aminotransferase ratio', 'urea measurement', 'viral load', '2-hydroxyacetaminophen sulfate measurement', 'aging', 'serum lipopolysaccharide activity', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'ependymoma', 'granulosa cell tumor', 'metaplastic breast carcinoma', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'ACTH-Producing Pituitary Gland Adenoma', 'Adenomatoid Odontogenic Tumor', 'Ampulla of Vater Carcinoma', 'Anal Squamous Cell Carcinoma', 'Anaplastic (Malignant) Meningioma', 'Appendix Adenocarcinoma', 'Appendix Goblet Cell Carcinoid', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Breast Carcinoma by Gene Expression Profile', 'cervical squamous cell carcinoma', 'Columnar Cell Hyperplasia of the Breast', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Extramammary Paget Disease', 'fibrodysplasia ossificans progressiva', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'Pallister-Hall syndrome', 'Nager acrofacial dysostosis', 'Marfan syndrome', 'Cowden syndrome 1', 'nail-patella syndrome', 'ovarian cancer', 'Andersen-Tawil syndrome', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'nonpapillary renal cell carcinoma', 'Mobius syndrome', 'Peyronie disease', 'prostate cancer', 'retinoblastoma', 'acrodermatitis enteropathica', 'mitochondrial DNA depletion syndrome 4a', 'Alstrom syndrome', 'anencephaly 1', 'microphthalmia with limb anomalies', 'Bloom syndrome', 'lung cancer', 'cerebrotendinous xanthomatosis', 'cystic fibrosis', 'recessive dystrophic epidermolysis bullosa', 'Haim-Munk syndrome', 'Laurence-Moon syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'ischemic cardiomyopathy', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'fibrosarcoma', 'hypertrophy', 'actinic keratosis', 'anaplastic astrocytoma', 'anaplastic oligodendroglioma', 'cardiac hypertrophy', 'AIDS dementia', 'pancreatic carcinoma', 'prostate intraepithelial neoplasia', 'thyroid carcinoma', 'insulin resistance', 'esophageal carcinoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'acute megakaryoblastic leukaemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'pleomorphic liposarcoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'Pick disease', 'testicular seminoma', 'osteomyelitis', 'spina bifida', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'lung disease', 'dental caries', 'serous adenocarcinoma', 'retinopathy', 'adrenal gland neoplasm'], tissue_specific_expression={'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\"small intestine Peyer's patch\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}, is_essential=False, genetic_constraint={'syn': 0.11195000261068344, 'mis': 4.47730016708374, 'lof': 1.0}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)', 'TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74', '*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.', '*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett\\\\'s esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'frontal lobe\\\\': -1, \\\\'endothelial cell of umbilical vein (resting)\\\\': 2, \\\\'zone of skin\\\\': 0, \\\\'regulatory T cell\\\\': 1, \\\\'pancreas\\\\': -1, \\\\'suprapubic skin\\\\': -1, \\\\'temporal lobe\\\\': -1, \\\\'parathyroid gland\\\\': -1, \\\\'spleen\\\\': -1, \\\\'Brodmann (1909) area 9\\\\': -1, \\\\'breast\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': -1, \\\\'alternatively activated macrophage\\\\': 2, \\\\'segmented neutrophil of bone marrow\\\\': 4, \\\\'placenta\\\\': -1, \\\\'mature eosinophil\\\\': 1, \\\\'granulocyte monocyte progenitor cell\\\\': 0, \\\\'gall bladder\\\\': -1, \\\\'esophagus muscularis mucosa\\\\': -1, \\\\'seminal vesicle\\\\': -1, \\\\'endocervix\\\\': -1, \\\\'lower leg skin\\\\': -1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 2, \\\\'CD8-positive, alpha-beta T cell\\\\': 3, \\\\'cerebral cortex\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': 4, \\\\'hippocampus proper\\\\': -1, \\\\'uterus\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': 3, \\\\'tonsil\\\\': -1, \\\\'esophagus\\\\': 0, \\\\'transverse colon\\\\': -1, \\\\'pituitary gland\\\\': -1, \\\\'coronary artery\\\\': -1, \\\\'memory B cell\\\\': 0, \\\\'sigmoid colon\\\\': -1, \\\\'cerebellum\\\\': -1, \\\\'erythroblast\\\\': 2, \\\\'prefrontal cortex\\\\': -1, \\\\'nucleus accumbens\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'vermiform appendix\\\\': -1, \\\\'greater omentum\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': 1, \\\\'leukocyte\\\\': 2, \\\\'adrenal gland\\\\': -1, \\\\'atrium auricular region\\\\': -1, \\\\'thyroid gland\\\\': 0, \\\\'tibial artery\\\\': -1, \\\\'common lymphoid progenitor\\\\': 3, \\\\'urinary bladder\\\\': -1, \\\\'duodenum\\\\': -1, \\\\'heart muscle\\\\': -1, \\\\'small intestine\\\\': -1, \\\\'neutrophilic metamyelocyte\\\\': 3, \\\\'minor salivary gland\\\\': -1, \\\\'rectum\\\\': 0, \\\\'ovary\\\\': -1, \\\\'substantia nigra\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': -1, \\\\'class switched memory B cell\\\\': 1, \\\\'fallopian tube\\\\': -1, \\\\'esophagus mucosa\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 0, \\\\'bronchus\\\\': -1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": -1, \\\\'kidney\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'macrophage\\\\': 1, \\\\'aorta\\\\': -1, \\\\'skeletal muscle tissue\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': 4, \\\\'caudate-putamen\\\\': -1, \\\\'liver\\\\': -1, \\\\'cytotoxic CD56-dim natural killer cell\\\\': 2, \\\\'mature neutrophil\\\\': 2, \\\\'hypothalamus\\\\': -1, \\\\'transformed skin fibroblast\\\\': -1, \\\\'bone marrow\\\\': -1, \\\\'inflammatory macrophage\\\\': 0, \\\\'cortex of kidney\\\\': -1, \\\\'lung\\\\': -1, \\\\'epididymis\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'saliva-secreting gland\\\\': -1, \\\\'nasopharynx\\\\': -1, \\\\'colon\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'stomach\\\\': -1, \\\\'testis\\\\': -1, \\\\'smooth muscle tissue\\\\': 0, \\\\'putamen\\\\': -1, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 5, \\\\'C1 segment of cervical spinal cord\\\\': 0, \\\\'blood\\\\': -1, \\\\'hematopoietic stem cell\\\\': 1, \\\\'caudate nucleus\\\\': -1, \\\\'amygdala\\\\': -1, \\\\'brain\\\\': 0, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'ectocervix\\\\': -1, \\\\'prostate gland\\\\': -1, \\\\'conventional dendritic cell\\\\': 4, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'heart left ventricle\\\\': -1, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 0, \\\\'vagina\\\\': -1, \\\\'esophagogastric junction\\\\': -1, \\\\'lymph node\\\\': -1, \\\\'endometrium\\\\': -1, \\\\'heart\\\\': -1, \\\\'oral mucosa\\\\': -1, \\\\'CD8-positive, alpha-beta thymocyte\\\\': 4, \\\\'common myeloid progenitor\\\\': 0, \\\\'tibial nerve\\\\': -1, \\\\'plasma cell\\\\': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0', '*HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709).'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets', 'reactome_pathways', 'humanbase_predictions']), 'SMAD3': Gene(identifiers=GeneIdentifiers(symbol='SMAD3', entrez_id='4088', uniprot_id='P84022', ensembl_id=None, aliases=[], gene_type=None), location=None, annotations=FunctionalAnnotations(go_annotations=['C:SMAD protein complex', 'C:chromatin', 'C:ciliary basal body', 'C:cytoplasm', 'C:cytosol', 'C:heteromeric SMAD protein complex', 'C:intracellular membrane-bounded organelle', 'C:nuclear inner membrane', 'C:nucleoplasm', 'C:nucleus', 'C:plasma membrane', 'C:receptor complex', 'C:transcription regulator complex', 'F:DEAD/H-box RNA helicase binding', 'F:DNA binding', 'F:DNA-binding transcription activator activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor activity', 'F:DNA-binding transcription factor activity, RNA polymerase II-specific', 'F:DNA-binding transcription factor binding', 'F:DNA-binding transcription repressor activity', 'F:I-SMAD binding', 'F:R-SMAD binding', 'F:RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'F:RNA polymerase II-specific DNA-binding transcription factor binding', 'F:bHLH transcription factor binding', 'F:beta-catenin binding', 'F:chromatin DNA binding', 'F:cis-regulatory region sequence-specific DNA binding', 'F:co-SMAD binding', 'F:collagen binding', 'F:identical protein binding', 'F:nuclear glucocorticoid receptor binding', 'F:nuclear mineralocorticoid receptor binding', 'F:nuclear receptor binding', 'F:phosphatase binding', 'F:promoter-specific chromatin binding', 'F:protein homodimerization activity', 'F:protein kinase binding', 'F:sequence-specific DNA binding', 'F:sterol response element binding', 'F:transcription cis-regulatory region binding', 'F:transcription coactivator binding', 'F:transcription corepressor binding', 'F:transforming growth factor beta receptor binding', 'F:ubiquitin binding', 'F:ubiquitin protein ligase binding', 'F:zinc ion binding', 'P:JNK cascade', 'P:SMAD protein signal transduction', 'P:T cell activation', 'P:activin receptor signaling pathway', 'P:adrenal gland development', 'P:anatomical structure morphogenesis', 'P:apoptotic signaling pathway', 'P:cell differentiation', 'P:cell population proliferation', 'P:cell-cell junction organization', 'P:cellular response to glucose stimulus', 'P:cellular response to transforming growth factor beta stimulus', 'P:cellular response to virus', 'P:developmental growth', 'P:embryonic cranial skeleton morphogenesis', 'P:embryonic foregut morphogenesis', 'P:embryonic pattern specification', 'P:endoderm development', 'P:extrinsic apoptotic signaling pathway', 'P:heart looping', 'P:immune response', 'P:immune system development', 'P:in utero embryonic development', 'P:lens fiber cell differentiation', 'P:liver development', 'P:mesoderm formation', 'P:negative regulation of apoptotic process', 'P:negative regulation of cardiac muscle hypertrophy in response to stress', 'P:negative regulation of cell differentiation', 'P:negative regulation of cell growth', 'P:negative regulation of cell population proliferation', 'P:negative regulation of cytosolic calcium ion concentration', 'P:negative regulation of fat cell differentiation', 'P:negative regulation of gene expression', 'P:negative regulation of inflammatory response', 'P:negative regulation of lung blood pressure', 'P:negative regulation of miRNA transcription', 'P:negative regulation of ossification', 'P:negative regulation of osteoblast differentiation', 'P:negative regulation of osteoblast proliferation', 'P:negative regulation of protein catabolic process', 'P:negative regulation of transcription by RNA polymerase II', 'P:negative regulation of wound healing', 'P:nodal signaling pathway', 'P:osteoblast development', 'P:paraxial mesoderm morphogenesis', 'P:pericardium development', 'P:positive regulation of DNA-templated transcription', 'P:positive regulation of SMAD protein signal transduction', 'P:positive regulation of bone mineralization', 'P:positive regulation of canonical Wnt signaling pathway', 'P:positive regulation of cell migration', 'P:positive regulation of chondrocyte differentiation', 'P:positive regulation of epithelial to mesenchymal transition', 'P:positive regulation of extracellular matrix assembly', 'P:positive regulation of focal adhesion assembly', 'P:positive regulation of gene expression', 'P:positive regulation of interleukin-1 beta production', 'P:positive regulation of miRNA transcription', 'P:positive regulation of nitric oxide biosynthetic process', 'P:positive regulation of positive chemotaxis', 'P:positive regulation of protein import into nucleus', 'P:positive regulation of stress fiber assembly', 'P:positive regulation of transcription by RNA polymerase II', 'P:positive regulation of transforming growth factor beta3 production', 'P:primary miRNA processing', 'P:protein stabilization', 'P:regulation of DNA-templated transcription', 'P:regulation of epithelial cell proliferation', 'P:regulation of immune response', 'P:regulation of miRNA transcription', 'P:regulation of mitochondrial membrane potential', 'P:regulation of striated muscle tissue development', 'P:regulation of transcription by RNA polymerase II', 'P:regulation of transforming growth factor beta receptor signaling pathway', 'P:regulation of transforming growth factor beta2 production', 'P:release of cytochrome c from mitochondria', 'P:response to angiotensin', 'P:response to hypoxia', 'P:signal transduction involved in regulation of gene expression', 'P:somitogenesis', 'P:thyroid gland development', 'P:transdifferentiation', 'P:transforming growth factor beta receptor signaling pathway', 'P:trophoblast cell migration', 'P:ureteric bud development', 'P:wound healing'], functions=['Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'], diseases=['Colorectal cancer', 'Loeys-Dietz syndrome 3'], pathways=['Cytokine Signaling in Immune system', 'Interleukin-1 family signaling', 'SMAD2/3 Phosphorylation Motif Mutants in Cancer', 'Developmental Biology', 'Viral Infection Pathways', 'Signaling by TGFBR3', 'Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer', 'Signaling by Interleukins', 'Deubiquitination', 'Signaling by NOTCH', 'TGF-beta receptor signaling activates SMADs', 'Signaling by TGFB family members', 'Loss of Function of TGFBR1 in Cancer', 'RUNX3 regulates CDKN1A transcription', 'SARS-CoV-1 targets host intracellular signalling and regulatory pathways', 'Signaling by TGF-beta Receptor Complex', 'TGFBR1 KD Mutants in Cancer', 'Post-translational protein modification', 'FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes', 'TGFBR3 expression', 'Disease', 'Generic Transcription Pathway', 'Metabolism of proteins', 'Gene expression (Transcription)', 'Signal Transduction', 'SARS-CoV-1-host interactions', 'FOXO-mediated transcription', 'Infectious disease', 'Gastrulation', 'RNA Polymerase II Transcription', 'SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription', 'NOTCH4 Intracellular Domain Regulates Transcription', 'FOXO-mediated transcription of cell cycle genes', 'Loss of Function of SMAD2/3 in Cancer', 'SMAD4 MH2 Domain Mutants in Cancer', 'Diseases of signal transduction by growth factor receptors and second messengers', 'SARS-CoV Infections', 'Formation of axial mesoderm', 'SARS-CoV-1 Infection', 'Germ layer formation at gastrulation', 'Signaling by NOTCH4', 'Downregulation of TGF-beta receptor signaling', 'Interleukin-37 signaling', 'Formation of definitive endoderm', 'RUNX3 regulates BCL2L11 (BIM) transcription', 'Ub-specific processing proteases', 'Loss of Function of SMAD4 in Cancer', 'Downregulation of SMAD2/3:SMAD4 transcriptional activity', 'Immune System', 'SMAD2/3 MH2 Domain Mutants in Cancer', 'Transcriptional regulation by RUNX3', 'Signaling by Activin', 'Signaling by TGF-beta Receptor Complex in Cancer', 'Signaling by NODAL'], cell_localizations=[], predicted_go=[], predicted_disease=[]), interactions=InteractionProfile(human_interactions={'Affinity Capture-Luminescence': ['BAG3', 'HIF1A', 'SMAD2', 'SMAD4', 'SMURF1', 'SMURF2', 'SP1'], 'Affinity Capture-MS': ['ARID1A', 'ATG14', 'ATG16L1', 'ATXN2L', 'BUB3', 'C1ORF116', 'CD6', 'CDK11A', 'CHD8', 'CIC', 'CREBBP', 'CSNK1D', 'CTNNB1', 'DCAF4', 'DCAF7', 'DDX3X', 'DDX3Y', 'DDX4', 'DHX8', 'DNAJA2', 'DOCK9', 'DYRK1A', 'DZIP3', 'EPB41L5', 'ERBB2IP', 'EVA1B', 'EZH2', 'FAM83G', 'FURIN', 'HINT3', 'HSPA4', 'IRF7', 'IRS1', 'ITGB4', 'KAT6A', 'KCTD16', 'LACRT', 'LDLRAD4', 'LEMD3', 'LRCH1', 'LSR', 'MAP2K3', 'MAPK1', 'MED16', 'MED4', 'NCOA3', 'NF2', 'OPA1', 'OTUB1', 'OTUD1', 'PABPC1', 'PARK2', 'PJA1', 'PLEKHA4', 'PPIE', 'PRNP', 'PSPC1', 'PTPN6', 'RAB11FIP5', 'RPL3', 'RPL4', 'RPSAP15', 'SIK3', 'SLC25A12', 'SLC9A3R2', 'SMAD1', 'SMAD2', 'SMAD4', 'SMAD5', 'SMAD9', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SMURF2', 'SNW1', 'SQRDL', 'SUZ12', 'TAF1', 'TAF2', 'TCP1', 'TGFB1', 'TMEM192', 'TRIM33', 'TRIM67', 'TRIP4', 'U2AF2', 'UGT1A10', 'USP33', 'USP7', 'VAV2', 'WWP2', 'YTHDF2', 'YY1', 'ZFP69B', 'ZFYVE9', 'ZRANB1'], 'Affinity Capture-RNA': ['DDX58', 'TRIM25'], 'Affinity Capture-Western': ['ACTB', 'ACVR1B', 'AKT1', 'ANAPC10', 'AR', 'ATF2', 'ATF3', 'BACH1', 'BRCA1', 'BRCA2', 'BTRC', 'CBL', 'CDC16', 'CDC25A', 'CDC27', 'CDKN1A', 'CEBPD', 'CHRD', 'CHUK', 'CITED2', 'CREBBP', 'CSNK1D', 'CSNK1G2', 'CTCF', 'CTNNB1', 'CUL1', 'DAB2', 'DACH1', 'DEDD', 'DOCK9', 'E2F4', 'EID2', 'ELAC2', 'EP300', 'ERBB2IP', 'ESR1', 'EZH2', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXL2', 'FOXM1', 'FOXO1', 'FOXO3', 'FOXO4', 'GRIP1', 'GSK3B', 'HDAC4', 'HDAC5', 'HGS', 'HIF1A', 'HNF4A', 'HYAL2', 'ID1', 'IRF7', 'JUN', 'KAT2A', 'KAT2B', 'KAT6A', 'KDM5C', 'KDM6B', 'KLF5', 'KPNB1', 'LEF1', 'MAFK', 'MECOM', 'MED15', 'MED24', 'MED6', 'MEN1', 'METTL14', 'METTL3', 'MKL1', 'MYC', 'MYD88', 'MYOCD', 'NCOA1', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIC', 'NFYC', 'NOTCH1', 'NOTCH4', 'NR3C1', 'NR4A1', 'NUP214', 'OTUB1', 'OTUD1', 'OVOL2', 'PAX6', 'PCK2', 'PDLIM5', 'PIAS3', 'PIAS4', 'PIN1', 'PITX1', 'PITX2', 'PML', 'PPARG', 'PPP1R12C', 'PRDM16', 'PRTN3', 'RARA', 'RBBP5', 'RBL1', 'RBX1', 'RELB', 'RGCC', 'RNF111', 'RNF31', 'RUNX1', 'RUNX2', 'RUNX3', 'S100A4', 'SETD2', 'SH2D2A', 'SKI', 'SKIL', 'SMAD2', 'SMAD3', 'SMAD4', 'SMAD7', 'SMARCA4', 'SMARCC2', 'SMURF1', 'SMURF2', 'SOX9', 'SP1', 'SPTBN1', 'SQSTM1', 'SREBF2', 'SRY', 'STRAP', 'STUB1', 'SUV39H1', 'TCF12', 'TGFB1I1', 'TGFBR1', 'TGFBR2', 'TGIF1', 'TGIF2', 'TOB1', 'TP53', 'TRIB3', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'TSC22D4', 'UCHL1', 'UCHL5', 'USP15', 'USP2', 'USP7', 'USP9X', 'WWOX', 'WWP1', 'WWP2', 'YAP1', 'ZC3H12A', 'ZEB1', 'ZEB2', 'ZFYVE9', 'ZMIZ1'], 'Biochemical Activity': ['CDK2', 'CDK4', 'CDK8', 'CDK9', 'CSNK1D', 'CSNK1G2', 'MAPK1', 'NEDD4', 'NEDD4L', 'OTUB1', 'TGFBR1', 'USP15', 'USP7', 'WWP2'], 'Co-crystal Structure': ['SMAD3', 'SMAD4', 'ZFYVE9'], 'Co-fractionation': ['ALKBH2', 'ANAPC10', 'APP', 'ARID1B', 'CDH1', 'CREBBP', 'CTCF', 'CTNNB1', 'CUL1', 'DDR1', 'FOXO3', 'HDAC1', 'HMGA2', 'IGF1R', 'ITGB1', 'JUND', 'MTA2', 'NAA15', 'NT5DC3', 'PARP1', 'PRKDC', 'RBM14', 'RBX1', 'RELA', 'RIPK1', 'RNMT', 'SIN3A', 'SKP1', 'SMAD2', 'SMARCA4', 'SMARCC1', 'SMARCC2', 'SNF8', 'SP1', 'SUB1', 'TRIM33', 'XRCC5', 'XRCC6', 'ZFHX3', 'ZFYVE9'], 'Co-localization': ['AKT1', 'BMP7', 'CAMK2G', 'CDK2', 'CDK4', 'EPAS1', 'ETS1', 'FOXO3', 'HIF1A', 'IRF7', 'MAP3K7', 'MAPK8', 'MAX', 'TP53', 'TRIM62'], 'Cross-Linking-MS (XL-MS)': ['RPL10A'], 'FRET': ['SMAD4', 'STUB1'], 'PCA': ['SMAD4', 'SMAD7'], 'Phenotypic Enhancement': ['HIF1A', 'SMAD2', 'SNW1'], 'Phenotypic Suppression': ['SMAD7', 'STRAP'], 'Positive Genetic': ['JAK1'], 'Protein-RNA': ['LINC00941'], 'Protein-peptide': ['CREBBP', 'FOXH1', 'ITCH', 'LEF1', 'NEDD4', 'PIN1'], 'Proximity Label-MS': ['NFIA'], 'Reconstituted Complex': ['ANAPC10', 'APP', 'AR', 'ATF2', 'ATF3', 'BPTF', 'BRCA1', 'BRCA2', 'CEBPA', 'CEBPB', 'CEBPD', 'CITED2', 'CREBBP', 'CTCF', 'DAB2', 'DDX5', 'DEDD', 'DNMT3L', 'DVL1', 'E2F4', 'EID2', 'EIF4B', 'EP300', 'ERBB2IP', 'FHL1', 'FHL2', 'FHL3', 'FOS', 'FOXH1', 'FOXM1', 'GSK3B', 'HDAC1', 'HDAC4', 'HDAC5', 'HIF1A', 'HIPK2', 'HNF4A', 'HYAL2', 'IRF7', 'ITCH', 'JUN', 'JUNB', 'JUND', 'KAT2B', 'KAT6A', 'KPNB1', 'LCK', 'LEF1', 'LEMD3', 'MAX', 'MDM4', 'MECOM', 'MYC', 'MYOCD', 'NEDD4', 'NEDD4L', 'NEDD9', 'NFIA', 'NOTCH1', 'NR3C1', 'NUP153', 'NUP214', 'PARD3', 'PIAS2', 'PIAS3', 'PIAS4', 'PIK3CA', 'PIN1', 'RBL1', 'RUNX2', 'S100A4', 'SH2D2A', 'SIN3A', 'SKI', 'SKIL', 'SMAD3', 'SMAD4', 'SMURF2', 'SNW1', 'SP1', 'STUB1', 'TFE3', 'TGFB1I1', 'TGFBR1', 'TGIF1', 'TP53', 'TRIM24', 'TRIM33', 'TRIM62', 'TSC2', 'UCHL5', 'USP15', 'VDR', 'WWOX', 'XPO6', 'YY1', 'ZFYVE9', 'ZMIZ1'], 'Two-hybrid': ['AATF', 'AES', 'ANK3', 'APMAP', 'APOB', 'AR', 'ATF2', 'BLZF1', 'C10ORF54', 'C14ORF105', 'CCDC33', 'CDC25A', 'CFDP1', 'CFH', 'CFLAR', 'CHRD', 'CORO1A', 'CPSF7', 'CPTP', 'CREBBP', 'CRX', 'CSH2', 'CXXC5', 'CYP11A1', 'DEDD', 'DNAJB4', 'DNAJB5', 'EBI3', 'EP300', 'EPAS1', 'FAM90A1', 'FBLN1', 'FLI1', 'FLNA', 'FOS', 'FOXH1', 'GGA1', 'GIT2', 'GMEB1', 'HDAC1', 'HEY1', 'HEYL', 'HIF1A', 'HIVEP1', 'HNRNPK', 'HOXC11', 'HP', 'ISL1', 'JUN', 'JUNB', 'KANSL1', 'KDM2A', 'KMT2B', 'LBP', 'MCM3AP', 'MEOX2', 'MTF2', 'MYC', 'MYD88', 'NCOA6', 'NEDD4', 'NEDD9', 'NR4A1', 'PAPPA', 'PARP4', 'PCDH1', 'PCK2', 'PHC2', 'PIAS4', 'PIN1', 'PLAG1', 'PLAGL1', 'PLG', 'PPP1R12C', 'PPP2R1A', 'PRDM4', 'PROX1', 'PSMB1', 'PSMD11', 'RANBP9', 'RBPMS', 'RBX1', 'RCVRN', 'RELA', 'RIOK2', 'RNF31', 'RPA1', 'RPLP0', 'SAP130', 'SBK3', 'SERTAD1', 'SETD2', 'SKIL', 'SMAD1', 'SMAD2', 'SMAD3', 'SMAD4', 'SMURF1', 'SMURF2', 'SNRNP70', 'SNW1', 'SP1', 'SQSTM1', 'SS18L1', 'ST6GALNAC2', 'SVEP1', 'TANK', 'TDP2', 'TEKT4', 'TF', 'TGM2', 'TLR4', 'TMED1', 'TSC22D4', 'UBQLN4', 'USP7', 'VDR', 'WWP1', 'WWP2', 'XRCC6', 'ZBTB16', 'ZBTB3', 'ZC3H12A', 'ZCCHC14', 'ZEB2', 'ZFYVE9', 'ZMYND11', 'ZNF329', 'ZNF774', 'ZNF83']}, nonhuman_interactions={'Affinity Capture-Luminescence': ['ARHGEF6', 'ARHGEF7', 'CLASRP', 'FBXO3', 'GSC', 'MAP2K3', 'PPP2R2D', 'RAB38', 'RASD2', 'RGS3', 'RRAS2', 'SMAD2', 'SMAD3', 'SQSTM1', 'TRIM35', 'WEE1', 'WWP2'], 'Affinity Capture-MS': ['ATG16L1', 'E6', 'NSP6', 'OTUB1', 'SMAD3'], 'Affinity Capture-Western': ['AXIN1', 'COL1A1', 'COL3A1', 'COL5A1', 'DDX5', 'DOK1', 'E6', 'E7', 'EP300', 'GATA4', 'GNB2L1', 'HCVGP1', 'HDAC4', 'KLF4', 'MED15', 'MELK', 'N', 'RNF111', 'SKI', 'SMAD3', 'SMAD3A', 'SMAD4', 'TGFB1I1', 'TOB1', 'TOB1A', 'TOB1B', 'VDR', 'ZEB1'], 'Co-localization': ['E7', 'N'], 'PCA': ['E6'], 'Phenotypic Enhancement': ['SMAD3A'], 'Phenotypic Suppression': ['SMAD3A'], 'Proximity Label-MS': ['M'], 'Reconstituted Complex': ['E6', 'E7', 'GATA4', 'N', 'SIN3A', 'SMAD3', 'SOX9', 'YAP1', 'ZFP128'], 'Synthetic Growth Defect': ['MMP9'], 'Two-hybrid': ['DVL1', 'E6', 'ERBB2IP', 'FOXH1', 'GATA4', 'HCVGP1', 'JUN', 'MAGI2', 'PARD3', 'SMAD3', 'ZEB2']}, go_enrichment={}), msigDB=MSigDBAnnotations(msigdb_annotations={'H': ['HALLMARK_TNFA_SIGNALING_VIA_NFKB', 'HALLMARK_G2M_CHECKPOINT', 'HALLMARK_UV_RESPONSE_DN', 'HALLMARK_TGF_BETA_SIGNALING'], 'C1': ['chr15q22'], 'C2': ['KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY', 'BIOCARTA_NTHI_PATHWAY', 'WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING', 'REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING', 'WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR', 'MITSIADES_RESPONSE_TO_APLIDIN_UP', 'TSAI_RESPONSE_TO_RADIATION_THERAPY', 'PUJANA_BREAST_CANCER_LIT_INT_NETWORK', 'WP_PANCREATIC_ADENOCARCINOMA_PATHWAY', 'GU_PDEF_TARGETS_UP', 'REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION', 'PID_TELOMERASE_PATHWAY', 'KEGG_ADHERENS_JUNCTION', 'KEGG_WNT_SIGNALING_PATHWAY', 'REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS', 'WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA', 'WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING', 'WP_PROGERIAASSOCIATED_LIPODYSTROPHY', 'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION', 'WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER', 'WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA', 'REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES', 'BROWNE_HCMV_INFECTION_4HR_DN', 'BROWNE_HCMV_INFECTION_14HR_DN', 'KIM_WT1_TARGETS_UP', 'RUTELLA_RESPONSE_TO_HGF_DN', 'DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP', 'PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN', 'WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING', 'LEI_MYB_TARGETS', 'FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL', 'WP_ENDODERM_DIFFERENTIATION', 'WP_TGFBETA_RECEPTOR_SIGNALING', 'MARTINEZ_RESPONSE_TO_TRABECTEDIN', 'WP_HEPATITIS_B_INFECTION', 'WP_CANCER_PATHWAYS', 'WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER', 'REACTOME_INFECTIOUS_DISEASE', 'REACTOME_SIGNALING_BY_INTERLEUKINS', 'SANA_TNF_SIGNALING_UP', 'REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS', 'JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP', 'WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES', 'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3', 'REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION', 'NAKAMURA_ADIPOGENESIS_LATE_DN', 'REACTOME_SARS_COV_1_HOST_INTERACTIONS', 'REACTOME_SIGNALING_BY_NODAL', 'REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION', 'PID_SMAD2_3NUCLEAR_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN', 'REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION', 'REACTOME_FORMATION_OF_AXIAL_MESODERM', 'GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN', 'WP_CELL_CYCLE', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN', 'CAIRO_HEPATOBLASTOMA_CLASSES_DN', 'PID_MYC_ACTIV_PATHWAY', 'SHEPARD_CRASH_AND_BURN_MUTANT_DN', 'ZHENG_BOUND_BY_FOXP3', 'WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES', 'RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP', 'REACTOME_INTERLEUKIN_37_SIGNALING', 'FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP', 'WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER', 'DACOSTA_UV_RESPONSE_VIA_ERCC3_DN', 'REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM', 'GENTILE_UV_RESPONSE_CLUSTER_D6', 'GENTILE_UV_HIGH_DOSE_DN', 'REACTOME_DEUBIQUITINATION', 'REACTOME_SARS_COV_INFECTIONS', 'BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN', 'WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS', 'TURJANSKI_MAPK1_AND_MAPK2_TARGETS', 'PULVER_FOREY_CELLCYCLE_PEAKING_M', 'REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES', 'ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES', 'BENPORATH_NANOG_TARGETS', 'LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP', 'WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER', 'DOANE_RESPONSE_TO_ANDROGEN_DN', 'REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING', 'MARTENS_BOUND_BY_PML_RARA_FUSION', 'FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS', 'MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN', 'RIZ_ERYTHROID_DIFFERENTIATION_6HR', 'REACTOME_SARS_COV_1_INFECTION', 'WP_HIPPO_SIGNALING_REGULATION', 'RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP', 'JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP', 'PID_MYC_REPRESS_PATHWAY', 'WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE', 'ONKEN_UVEAL_MELANOMA_UP', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2', 'PHONG_TNF_RESPONSE_VIA_P38_PARTIAL', 'JOHNSTONE_PARVB_TARGETS_2_UP', 'OKUMURA_INFLAMMATORY_RESPONSE_LPS', 'BIOCARTA_TOB1_PATHWAY', 'GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN', 'KEGG_CELL_CYCLE', 'WP_1P36_COPY_NUMBER_VARIATION_SYNDROME', 'DAZARD_RESPONSE_TO_UV_NHEK_DN', 'WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY', 'OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN', 'RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN', 'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM', 'WP_AGERAGE_PATHWAY', 'KEGG_PANCREATIC_CANCER', 'MARSON_BOUND_BY_FOXP3_UNSTIMULATED', 'FIGUEROA_AML_METHYLATION_CLUSTER_3_UP', 'LINDGREN_BLADDER_CANCER_CLUSTER_3_DN', 'REACTOME_GASTRULATION', 'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION', 'BENPORATH_MYC_MAX_TARGETS', 'WP_INTEGRATED_CANCER_PATHWAY', 'KEGG_CHRONIC_MYELOID_LEUKEMIA', 'REACTOME_SIGNALING_BY_TGFBR3', 'BENPORATH_SOX2_TARGETS', 'KEGG_TGF_BETA_SIGNALING_PATHWAY', 'WP_ANDROGEN_RECEPTOR_SIGNALING', 'PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2', 'JOHNSTONE_PARVB_TARGETS_3_UP', 'BIOCARTA_TGFB_PATHWAY', 'CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN', 'REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY', 'KEGG_PATHWAYS_IN_CANCER', 'WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE', 'WP_UROTENSINIIMEDIATED_SIGNALING', 'WP_MESODERMAL_COMMITMENT_PATHWAY', 'TSAI_RESPONSE_TO_IONIZING_RADIATION', 'LAMB_CCND1_TARGETS', 'REACTOME_VIRAL_INFECTION_PATHWAYS', 'WP_TGFB_SMAD_SIGNALING', 'DAZARD_UV_RESPONSE_CLUSTER_G6', 'REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX', 'WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION', 'REACTOME_SIGNALING_BY_NOTCH', 'FRASOR_RESPONSE_TO_ESTRADIOL_DN', 'ZIRN_TRETINOIN_RESPONSE_WT1_UP', 'KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3', 'BROWNE_HCMV_INFECTION_8HR_DN', 'ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF', 'REN_ALVEOLAR_RHABDOMYOSARCOMA_DN', 'REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION', 'PID_HIF1_TFPATHWAY', 'GRUETZMANN_PANCREATIC_CANCER_UP', 'CHICAS_RB1_TARGETS_CONFLUENT', 'YEMELYANOV_GR_TARGETS_DN', 'WP_OVARIAN_INFERTILITY', 'PHONG_TNF_RESPONSE_NOT_VIA_P38', 'WP_ADIPOGENESIS', 'DANG_BOUND_BY_MYC', 'WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING', 'DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN', 'BIOCARTA_G1_PATHWAY', 'REACTOME_SIGNALING_BY_NOTCH4', 'SERVITJA_ISLET_HNF1A_TARGETS_UP', 'WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS', 'WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY', 'WP_NEOVASCULARIZATION_PROCESSES', 'REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER', 'KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY', 'PID_SMAD2_3PATHWAY', 'CHANDRAN_METASTASIS_DN', 'WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT', 'PEREZ_TP53_TARGETS', 'KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY', 'KIM_WT1_TARGETS_12HR_UP', 'WP_BURN_WOUND_HEALING', 'REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER', 'WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER', 'PID_TGFBR_PATHWAY', 'WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY', 'BROWNE_HCMV_INFECTION_6HR_DN', 'REACTOME_FOXO_MEDIATED_TRANSCRIPTION', 'REACTOME_TGFBR3_EXPRESSION', 'SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1', 'KEGG_COLORECTAL_CANCER', 'RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN', 'REACTOME_SIGNALING_BY_ACTIVIN', 'REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS'], 'C3': ['WGGAATGY_TEF1_Q6', 'MIR302D_5P', 'GTTAAAG_MIR302B', 'MIR8080', 'PXR_Q2', 'SRY_02', 'GGCAGAC_MIR346', 'HDAC4_TARGET_GENES', 'ZNF563_TARGET_GENES', 'ZNF766_TARGET_GENES', 'MEF2C_TARGET_GENES', 'ZFHX3_TARGET_GENES', 'TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497', 'MIR524_5P', 'MIR6129', 'ZFP3_TARGET_GENES', 'E12_Q6', 'ZSCAN30_TARGET_GENES', 'GREB1_TARGET_GENES', 'MIR3120_5P', 'MIR668_3P', 'MYOD_Q6_01', 'RYTTCCTG_ETS2_B', 'MIR6127', 'MIR145_5P', 'TAL1BETAE47_01', 'SKIL_TARGET_GENES', 'MIR6130', 'ZNF436_TARGET_GENES', 'AACTGGA_MIR145', 'NR0B1_TARGET_GENES', 'KMT2D_TARGET_GENES', 'SNAI1_TARGET_GENES', 'TAL1ALPHAE47_01', 'MED25_TARGET_GENES', 'MIR20A_3P', 'TFEB_TARGET_GENES', 'TBX1_TARGET_GENES', 'MIR6886_3P', 'AATGTGA_MIR23A_MIR23B', 'SUPT16H_TARGET_GENES', 'AGCTCCT_MIR28', 'NGFIC_01', 'MIR3194_3P', 'ZNF512B_TARGET_GENES', 'TAL1BETAITF2_01', 'GATA1_05', 'ZNF282_TARGET_GENES', 'ZNF740_TARGET_GENES', 'ZSCAN2_TARGET_GENES', 'MIR6762_5P', 'MIR561_3P', 'MIR617', 'ZNF92_TARGET_GENES', 'HMX1_01', 'LFA1_Q6', 'MIR6845_5P', 'DLX2_TARGET_GENES', 'SALL4_TARGET_GENES', 'MIR520D_5P', 'MIR4778_3P', 'MIR302B_5P', 'MIR6765_3P', 'CTTTGTA_MIR524', 'MIR4510', 'MIR520G_3P_MIR520H', 'MIR6133', 'MIR5195_3P', 'CTAWWWATA_RSRFC4_Q2', 'SFMBT1_TARGET_GENES', 'ARID5B_TARGET_GENES', 'EWSR1_TARGET_GENES', 'COUP_DR1_Q6', 'MIR3658', 'GCTNWTTGK_UNKNOWN', 'ZNF596_TARGET_GENES', 'ZSCAN5DP_TARGET_GENES', 'ATGTCAC_MIR489', 'NAB2_TARGET_GENES', 'ZNF746_TARGET_GENES', 'PBXIP1_TARGET_GENES', 'MIR3154', 'FXR_IR1_Q6', 'MIR5787', 'ADNP_TARGET_GENES', 'MIR4505'], 'C4': ['MODULE_378', 'MODULE_37', 'MODULE_57', 'MODULE_129', 'MODULE_179', 'MODULE_3', 'MODULE_69', 'MODULE_70', 'MODULE_117', 'MODULE_138', 'MODULE_255', 'MODULE_459', 'MODULE_532', 'MODULE_18', 'MODULE_136', 'MODULE_33', 'MODULE_317'], 'C6': ['RPS14_DN.V1_UP'], 'C7': ['GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN', 'GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN', 'GSE29949_MICROGLIA_VS_DC_BRAIN_DN', 'GSE22886_NAIVE_BCELL_VS_DC_UP', 'GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP', 'GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP', 'GSE20366_TREG_VS_TCONV_UP', 'GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP', 'GSE40443_INDUCED_VS_TOTAL_TREG_UP', 'GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP', 'GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE1460_DP_VS_CD4_THYMOCYTE_DN', 'GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN', 'GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN', 'NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN', 'GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP', 'FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP', 'SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP', 'GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP', 'GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN', 'GSE3982_MAC_VS_TH1_DN', 'GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP', 'GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN', 'GSE20727_CTRL_VS_H2O2_TREATED_DC_DN', 'GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP', 'GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN', 'GSE369_IFNG_KO_VS_WT_LIVER_UP', 'GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP', 'NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP', 'GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP', 'GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP', 'GSE7852_LN_VS_FAT_TREG_DN', 'GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP', 'GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP', 'GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN', 'GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP', 'GSE2585_CTEC_VS_THYMIC_DC_DN', 'GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN', 'GSE14350_TREG_VS_TEFF_UP', 'GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP', 'GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN', 'GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP', 'GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN', 'GSE14415_INDUCED_TREG_VS_TCONV_DN', 'GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN', 'GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP', 'GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP', 'GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP', 'GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN', 'GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP', 'GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN', 'GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN', 'GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN', 'GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN', 'GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN', 'NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN', 'GSE17186_MEMORY_VS_NAIVE_BCELL_UP', 'GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP', 'GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP', 'GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP', 'GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP', 'GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN', 'GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP', 'GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN', 'GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN', 'GSE7852_THYMUS_VS_FAT_TREG_DN', 'GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP', 'GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP', 'GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP', 'GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP', 'GSE360_CTRL_VS_L_MAJOR_MAC_UP', 'GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN', 'GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP', 'GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP', 'GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP', 'GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP', 'GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN', 'GSE40273_EOS_KO_VS_WT_TREG_UP', 'GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP', 'GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP', 'GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN', 'GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN', 'GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP', 'GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP', 'GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN', 'GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP', 'GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP', 'GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN', 'GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN', 'GSE12505_WT_VS_E2_2_HET_PDC_UP', 'GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP', 'GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN', 'GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP', 'GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN', 'GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP', 'GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP', 'GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP', 'GSE27786_CD4_TCELL_VS_NKTCELL_DN', 'GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN', 'GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP', 'NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN', 'GSE2585_CTEC_VS_MTEC_THYMUS_UP', 'GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN', 'NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP', 'GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP', 'GSE7764_NKCELL_VS_SPLENOCYTE_UP', 'GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN', 'GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP', 'GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN', 'GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN', 'GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP', 'GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN', 'GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN', 'GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP', 'GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP'], 'C8': ['FAN_OVARY_CL11_MURAL_GRANULOSA_CELL', 'MURARO_PANCREAS_DUCTAL_CELL', 'GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS', 'FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2', 'HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL', 'HU_FETAL_RETINA_FIBROBLAST', 'HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL', 'MURARO_PANCREAS_ACINAR_CELL', 'HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL', 'HU_FETAL_RETINA_RPE']}), omim=OMIMAnnotations(phenotype_annotations=[]), disgenet=DisGeNetAnnotations(disease_annotations=[]), open_targets=OpenTargetAnnotations(disease_annotations=['Large for gestational age', 'Alopecia', 'Abnormality of the cardiovascular system', 'Mitral valve prolapse', 'Congestive heart failure', 'Patent ductus arteriosus', 'Dilated cardiomyopathy', 'Bicuspid aortic valve', 'Right ventricular hypertrophy', 'Myocardial fibrosis', 'Hallux valgus', 'Increased total eosinophil count', 'Acute kidney injury', 'Renal artery stenosis', 'Hypoglycemia', 'Glucose intolerance', 'Abnormal thrombosis', 'Rectal prolapse', 'Esophageal stricture', 'Pulmonary hypoplasia', 'Asthma', 'Cerebral cortical atrophy', 'Ischemic stroke', 'Aortic root aneurysm', 'Aortic dissection', 'Spontaneous pneumothorax', 'Vascular dilatation', 'Cerebral ischemia', 'Immunodeficiency', 'Systemic lupus erythematosus', 'Oral leukoplakia', 'Autoimmunity', 'Hyperglycemia', 'Hyperlipidemia', 'Hypercholesterolemia', 'Back pain', 'Muscular dystrophy', 'Hernia of the abdominal wall', 'Cachexia', 'Ascending aortic dissection', 'Venous thrombosis', 'Ascending tubular aorta aneurysm', 'Ureteral obstruction', 'Airway obstruction', 'Pituitary prolactin cell adenoma', 'Premature ovarian insufficiency', 'Intervertebral disk degeneration', 'Lipodystrophy', 'Hamartoma', 'Chordoma', 'Stress urinary incontinence', 'Inflammatory abnormality of the skin', 'Arrhythmia', 'Myelofibrosis', 'Hepatitis', 'Urethral stricture', 'Allergy', 'Renal atrophy', 'Pulmonary bulla', 'Chronic colitis', 'Neoplasm of the lung', 'Cognitive impairment', 'Hernia', 'Sepsis', 'Skin ulcer', 'Left ventricular dilatation', 'colorectal adenoma', 'airway hyperresponsiveness', 'skin aging', 'adolescent idiopathic scoliosis', 'triple-negative breast cancer', 'bile duct carcinoma', 'glioma', 'gamma chain deficiency', 'seborrheic keratosis', 'rectal adenocarcinoma', 'intracerebral hemorrhage', 'smoking initiation', 'Staphylococcus aureus infection', 'rheumatic disease', 'lupus nephritis', 'pulse pressure measurement', 'neurodegenerative disease', 'retinal detachment', 'Autoimmune Hepatitis', 'non-high density lipoprotein cholesterol measurement', 'brain disease', 'aortic disease', 'neonatal abstinence syndrome', 'allergic rhinitis', 'esophageal squamous cell carcinoma', 'non-Hodgkins lymphoma', 'breast ductal adenocarcinoma', 'systolic blood pressure', 'diastolic blood pressure', 'pulmonary artery enlargement', 'laryngeal squamous cell carcinoma', 'cystadenocarcinoma', 'ovarian mucinous adenocarcinoma', 'smoking status measurement', 'bladder transitional cell carcinoma', 'brain glioblastoma', 'cerebral amyloid angiopathy', 'autoimmune thyroid disease', 'stricture', 'head and neck malignant neoplasia', 'urgency urinary incontinence', 'fibrosis', 'diastolic blood pressure change measurement', 'drug use measurement', 'allergic conjunctivitis', 'aortic valve insufficiency', 'Balkan nephropathy', 'bronchiolitis obliterans', 'congenital rubella', 'coronavirus infectious disease', 'echinococcosis', 'endodermal sinus tumor', 'Gerstmann syndrome', 'Guillain-Barre syndrome', 'influenza', 'intestinal cancer', 'legionellosis', 'lymphatic system disease', 'male reproductive organ cancer', 'aneurysm-osteoarthritis syndrome', 'autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome', 'hyperuricemic nephropathy, familial juvenile type 3', 'graft versus host disease', 'autoimmune lymphoproliferative syndrome type 4', 'combined immunodeficiency due to LRBA deficiency', 'adenine phosphoribosyltransferase deficiency', 'karyomegalic interstitial nephritis', 'dyskeratosis congenita, autosomal recessive 5', 'TCR-alpha-beta-positive T-cell deficiency', 'severe combined immunodeficiency due to IKK2 deficiency', 'immunodeficiency 18', 'immunodeficiency 23', 'severe combined immunodeficiency due to CTPS1 deficiency', 'severe neurodegenerative syndrome with lipodystrophy', 'periodic fever-infantile enterocolitis-autoinflammatory syndrome', 'immunodeficiency 37', 'chronic atrial and intestinal dysrhythmia', 'DOCK2 deficiency', 'DDX41-related hematologic malignancy predisposition syndrome', 'fibrochondrogenesis 2', 'C3 glomerulonephritis', 'agammaglobulinemia 7, autosomal recessive', 'autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency', 'infantile-onset periodic fever-panniculitis-dermatosis syndrome', 'lung disease, immunodeficiency, and chromosome breakage syndrome;', 'neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade', 'chronic diarrhea due to glucoamylase deficiency', 'Bardet-Biedl syndrome', 'familial pancreatic carcinoma', 'nasopharyngeal carcinoma', 'craniosynostosis', 'keratoconus', 'common variable immunodeficiency', 'hyperplastic polyposis syndrome', 'dentin dysplasia', 'T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency', 'early myoclonic encephalopathy', 'laryngotracheoesophageal cleft', 'cleft palate', 'qualitative or quantitative defects of dysferlin', 'holoprosencephaly', 'attenuated familial adenomatous polyposis', 'isolated agammaglobulinemia', 'pachyonychia congenita', 'familial hyperaldosteronism', 'hypohidrotic ectodermal dysplasia', 'primary ciliary dyskinesia', 'APC-related attenuated familial adenomatous polyposis', 'meningioma', 'multiple epiphyseal dysplasia', 'hemangioblastoma', 'Moyamoya disease', 'thanatophoric dysplasia', 'idiopathic pulmonary arterial hypertension', 'IgG4-related disease', 'juvenile polyposis syndrome', 'pituitary tumor', 'ameloblastoma', 'exstrophy-epispadias complex', 'autoimmune lymphoproliferative syndrome', 'syringomyelia', 'selective IgM deficiency', 'persistent truncus arteriosus', 'colorectal adenocarcinoma', 'congestive heart failure', \\\"Crohn's disease\\\", 'cutaneous melanoma', 'diabetes mellitus', 'diabetic nephropathy', 'diffuse gastric adenocarcinoma', 'diffuse large B-cell lymphoma', 'breast ductal carcinoma in situ', 'embryonal rhabdomyosarcoma', 'emphysema', 'epilepsy', 'fetal growth restriction', 'ganglioneuroma', 'gastric adenocarcinoma', 'esophageal adenocarcinoma', 'gastric intestinal type adenocarcinoma', 'glioblastoma multiforme', 'hypertension', 'hypertrophic cardiomyopathy', 'immune system disease', 'infection', 'infertility', 'injury', 'insulinoma', 'intracranial hemorrhage', 'ischemia', 'leukemia', 'lung adenocarcinoma', 'lymphoma', 'mesothelioma', 'metabolic disease', 'myocardial infarction', 'neoplasm', 'nervous system disease', 'neuroblastoma', 'oligodendroglioma', 'osteosarcoma', 'tuberculosis', 'glioblastoma', 'chronic granulomatous disease', 'liver mesenchymal hamartoma', 'activated PI3K-delta syndrome', 'carcinoma of liver and intrahepatic biliary tract', 'cutaneous polyarteritis nodosa', 'hereditary nonpolyposis colon cancer', 'Polymerase proofreading-related adenomatous polyposis', 'Zika virus infectious disease', 'regressive spondylometaphyseal dysplasia', 'Jeune syndrome', 'Li-Fraumeni syndrome', 'posterior cortical atrophy', '22q11.2 deletion syndrome', 'Loeys-Dietz syndrome', 'congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization', 'intrahepatic cholestasis', 'bronchopulmonary dysplasia', 'Hirschsprung disease', 'mucinous adenocarcinoma of the appendix', 'Lhermitte-Duclos disease', 'sarcoidosis', 'peeling skin syndrome', 'Fanconi anemia', 'dysspondyloenchondromatosis', 'adult T-cell leukemia/lymphoma', 'extranodal nasal NK/T cell lymphoma', 'Turner syndrome', 'acute liver failure', 'discoid lupus erythematosus', 'familial thoracic aortic aneurysm and aortic dissection', 'renal hypoplasia', 'renal dysplasia', 'spondyloepiphyseal dysplasia tarda', 'ulnar hemimelia', 'radial hemimelia', 'growth hormone-producing pituitary gland neoplasm', 'encephalitis', 'Ehlers-Danlos syndrome', 'muscular dystrophy', 'autosomal dominant cerebellar ataxia', 'precursor B-cell acute lymphoblastic leukemia', 'chronic graft versus host disease', 'superficial spreading melanoma', 'renal pelvis/ureter urothelial carcinoma', 'tubulointerstitial kidney disease, autosomal dominant, 2', 'lung neoplasm', 'intestinal neoplasm', 'prostate neoplasm', 'mucoepidermoid carcinoma of parotid gland', 'neoplasm of esophagus', 'tumor of parathyroid gland', 'polyp of colon', 'low grade glioma', 'coronary atherosclerosis', 'gram-negative bacterial infections', 'sexually transmitted disease', 'radiculitis', 'viral myocarditis', 'lip and oral cavity carcinoma', 'immunodeficiency 14b, autosomal recessive', 'corneal infection', 'pseudoxanthoma elasticum (inherited or acquired)', 'respiratory tract infectious disorder', 'chondrogenic neoplasm', 'squamous cell intraepithelial neoplasia', 'liver and intrahepatic bile duct neoplasm', 'hypertensive nephropathy', 'myocardial disorder', 'tubular adenoma', 'synucleinopathy', 'pulmonary sarcoidosis', 'gonorrhea', 'chronic lymphocytic leukemia', 'neoplasm of mature B-cells', 'gastric carcinoma', 'head and neck squamous cell carcinoma', 'hepatocellular carcinoma', 'metastatic prostate cancer', 'T-cell acute lymphoblastic leukemia', 'unspecified peripheral T-cell lymphoma', 'Hodgkins lymphoma', 'invasive breast ductal carcinoma', 'metabolic syndrome', 'oral squamous cell carcinoma', 'acute lymphoblastic leukemia', 'acute myeloid leukemia', 'adenocarcinoma', 'adenoma', 'adenosquamous lung carcinoma', 'adrenal gland pheochromocytoma', 'alveolar rhabdomyosarcoma', 'aortic stenosis', 'astrocytoma', 'atopic eczema', 'atrial fibrillation', 'benign prostatic hyperplasia', 'breast adenocarcinoma', 'breast carcinoma', 'bronchoalveolar adenocarcinoma', 'Burkitts lymphoma', 'carcinoma', 'cardiomyopathy', 'cardiovascular disease', 'chondrosarcoma', 'chronic myelogenous leukemia', 'chronic obstructive pulmonary disease', 'chronic pancreatitis', 'clear cell renal carcinoma', 'endometrial carcinoma', 'renal fibrosis', 'Adenomyosis', 'immunoproliferative small intestinal disease', 'Posterior Leukoencephalopathy Syndrome', 'amyloidosis', 'neuroendocrine neoplasm', 'Spinal cord injury', 'B-cell non-Hodgkins lymphoma', 'colon adenocarcinoma', 'colon carcinoma', 'colorectal carcinoma', 'intrahepatic cholangiocarcinoma', 'pharyngeal squamous cell carcinoma', 'connective tissue disease', 'pneumonitis', 'Carcinoma, Lewis Lung', 'soft tissue sarcoma', 'adult onset asthma', 'chronic rhinosinusitis with nasal polyps', 'chronic rhinosinusitis without nasal polyps', 'renal hypertension', 'glomerular disease', 'nephritis', 'positive regulation of ovulation', 'Neurogenic bladder', 'Inguinal hernia', 'Abnormality of the urinary system', 'Renal insufficiency', 'Glomerular sclerosis', 'Glomerulonephritis', 'Nephropathy', 'Nephrocalcinosis', 'Uterine leiomyoma', 'Cleft palate', 'Retrognathia', 'Strabismus', 'Cataract', 'Proptosis', 'Myopia', 'Pectus excavatum', 'Infertility', 'Hematuria', 'Diabetes mellitus', 'Hyperinsulinemia', 'Insulin resistance', 'Abnormality of the skeletal system', 'Osteopenia', 'Osteoporosis', 'Jaundice', 'Eczematoid dermatitis', 'Global developmental delay', 'Stroke', 'Encephalopathy', 'Parkinsonism', 'Rheumatoid arthritis', 'Cirrhosis', 'Hepatic fibrosis', 'Cholestasis', 'Hepatic steatosis', 'Obesity', 'ornithine carbamoyltransferase deficiency', 'pseudomyxoma peritonei', 'silicosis', 'spinal stenosis', 'BMI-adjusted waist-hip ratio', 'BMI-adjusted waist circumference', 'body fat percentage', 'balding measurement', 'liver dysplastic nodule', 'wellbeing measurement', 'insomnia measurement', 'eosinophil percentage of leukocytes', 'eosinophil percentage of granulocytes', 'BMI-adjusted hip circumference', 'calf circumference measurement', 'chronic hepatitis', 'dysplasia', 'interstitial cystitis', 'lobular breast carcinoma', 'nodular melanoma', 'non-functioning pituitary adenoma', 'oral lichen planus', 'rhinitis', 'small cell carcinoma', 'status epilepticus', 'steatosis', 'urothelial carcinoma', 'Hepatobiliary Neoplasm', 'acute myocardial infarction', 'peritonitis', 'pemphigus foliaceus', 'paraneoplastic pemphigus', 'cystic kidney disease', 'ovarian dysfunction', 'Arteritis', 'Polyarteritis Nodosa', 'arteriosclerosis', 'idiopathic dilated cardiomyopathy', 'hyperuricemia', 'female reproductive endometrioid cancer', 'skin carcinoma', 'heel bone mineral density', 'marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections', 'central nervous system disease', 'sum of eosinophil and basophil counts', 'lower respiratory tract disease', 'pulmonary fibrosis', 'infarction', 'corneal disease', 'vertebral joint disease', 'aortic valve disease', 'cervical disc degenerative disorder', 'hemorrhoid', 'mitral valve disease', 'feeling nervous measurement', 'stomach disease', 'myocarditis', 'aneurysm', 'laryngeal disease', 'musculoskeletal system disease', 'Gallbladder Adenocarcinoma', 'Gallbladder Adenoma', 'Gastric Neuroendocrine Tumor G1', 'Granular Cell Tumor', 'Hepatoblastoma', 'HER2 Positive Breast Carcinoma', 'Invasive Breast Carcinoma', 'Mast Cell Sarcoma', 'Nasal Cavity Polyp', 'Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation', 'Ovarian Endometriosis', 'Ovarian Granulosa Cell Tumor', 'Peritoneal Multicystic Mesothelioma', 'Pituitary Gland Adenoma', 'Placental Choriocarcinoma', 'Pleural Epithelioid Mesothelioma', 'Poorly Differentiated Thyroid Gland Carcinoma', 'Rectal Tubular Adenoma', 'Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions', 'Signet Ring Cell Gastric Adenocarcinoma', 'small intestinal adenocarcinoma', 'Spinal Chordoma', 'Testicular Embryonal Carcinoma', 'Thyroid Gland Oncocytic Follicular Carcinoma', 'Thyroid Gland Undifferentiated (Anaplastic) Carcinoma', 'Uterine Carcinosarcoma', 'Vaginal Melanoma', 'hamartoma', 'acute respiratory distress syndrome', 'rectum cancer', 'acanthosis nigricans', 'cholesteatoma', 'Primary Pulmonary Diffuse Large B-Cell Lymphoma', 'developmental dysplasia of the hip', 'sarcopenia', 'mucous membrane pemphigoid', 'osteoarthritis, hip', 'osteoarthritis, spine', 'adrenal cortex carcinoma', 'adrenal gland hyperfunction', 'alcoholic cardiomyopathy', 'aortitis', 'atrial heart septal defect', 'causalgia', 'coronary aneurysm', 'diastolic heart failure', 'dry eye syndrome', 'Helicobacter pylori infectious disease', 'inflammatory breast carcinoma', 'joint disease', 'lipoid nephrosis', 'mouth disease', 'multiple system atrophy', 'myeloid sarcoma', 'ocular hypertension', 'parathyroid adenoma', 'proliferative vitreoretinopathy', 'pulmonary edema', 'pulpitis', 'Raynaud disease', 'renovascular hypertension', 'rheumatic heart disease', 'Schnitzler syndrome', 'thromboangiitis obliterans', 'ulcerative proctosigmoiditis', 'uremia', 'non-alcoholic steatohepatitis', 'rotator cuff tear', 'Anemia, Hemolytic, Autoimmune', 'Cardiac Tamponade', 'End Stage Liver Disease', 'Endometritis', 'Escherichia coli Infections', 'Genital neoplasm, female', 'Heavy Chain Disease', 'Hepatopulmonary Syndrome', 'Lentivirus Infections', 'Myocardial Ischemia', 'Periapical Periodontitis', 'Peritoneal Fibrosis', 'Tularemia', 'diabetic cardiomyopathy', 'endothelial dysfunction', 'gliosarcoma', 'Mantle cell lymphoma', 'Merkel cell skin cancer', 'metastatic colorectal cancer', 'enterocolitis', 'primary biliary cirrhosis', 'abortion', 'psoriasis vulgaris', 'Autosomal dominant polycystic kidney disease', 'osteoporosis-pseudoglioma syndrome', 'primary hyperoxaluria type 2', 'hyperimmunoglobulinemia D with periodic fever', 'autosomal recessive polycystic kidney disease', 'Senior-Loken syndrome 1', 'reticular dysgenesis', 'schneckenbecken dysplasia', 'combined immunodeficiency due to ZAP70 deficiency', 'familial isolated congenital asplenia', 'brachyolmia type 1, Hobaek type', 'brachyolmia type 1, toledo type', 'spondyloperipheral dysplasia', 'thoracomelic dysplasia', 'congenital bilateral aplasia of vas deferens from CFTR mutation', 'Wilson disease', 'X-linked spondyloepimetaphyseal dysplasia', 'hypoxanthine guanine phosphoribosyltransferase partial deficiency', 'Bruton-type agammaglobulinemia', 'X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia', 'combined immunodeficiency due to moesin deficiency', 'Wiskott-Aldrich syndrome', 'Aarskog-Scott syndrome, X-linked', 'hyper-IgM syndrome type 1', 'Melnick-Needles syndrome', 'Bartsocas-Papas syndrome 1', 'pulmonary venoocclusive disease', 'spondyloepimetaphyseal dysplasia, Irapa type', 'SHOX-related short stature', 'immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome', 'Duchenne muscular dystrophy', 'X-linked retinoschisis', 'spondyloepiphyseal dysplasia tarda, X-linked', 'T-B+ severe combined immunodeficiency due to JAK3 deficiency', 'Timothy syndrome', 'supranuclear palsy, progressive, 1', 'skeletal dysplasia-epilepsy-short stature syndrome', 'hereditary mixed polyposis syndrome', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive', 'Ehlers-Danlos syndrome, musculocontractural type', 'spondyloepimetaphyseal dysplasia, Missouri type', 'axial spondylometaphyseal dysplasia', 'severe combined immunodeficiency due to DCLRE1C deficiency', 'spondyloepimetaphyseal dysplasia, Shohat type', 'myotonic dystrophy type 2', 'radioulnar synostosis-microcephaly-scoliosis syndrome', 'spondyloepimetaphyseal dysplasia with multiple dislocations', 'Omenn syndrome', 'xanthinuria type II', 'autoimmune lymphoproliferative syndrome type 2A', 'nephronophthisis 3', 'pyogenic arthritis-pyoderma gangrenosum-acne syndrome', 'hyper-IgM syndrome type 2', 'immunodeficiency due to CD25 deficiency', 'lymphangioleiomyomatosis', 'gastrointestinal stromal tumor', 'hyper-IgM syndrome type 3', 'multiple epiphyseal dysplasia type 5', 'anauxetic dysplasia', 'autoimmune lymphoproliferative syndrome type 2B', 'Smith-McCort dysplasia 1', 'granular corneal dystrophy type II', 'acrocapitofemoral dysplasia', 'endometrial cancer', 'hyper-IgM syndrome type 5', 'hyper-IgM syndrome type 4', 'neutrophil immunodeficiency syndrome', 'familial adenomatous polyposis 2', 'spondyloepimetaphyseal dysplasia, matrilin-3 type', 'familial avascular necrosis of femoral head', 'immunodeficiency 104', 'spondylometaphyseal dysplasia, A4 type', 'epidermolysis bullosa simplex 7, with nephropathy and deafness', 'permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome', 'mesoaxial synostotic syndactyly with phalangeal reduction', 'hyperinsulinemic hypoglycemia, familial, 4', 'Mungan syndrome', 'familial cold autoinflammatory syndrome 2', 'aortic aneurysm, familial thoracic 6', 'hypouricemia, renal, 2', 'dopa-responsive dystonia due to sepiapterin reductase deficiency', 'combined immunodeficiency due to STIM1 deficiency', 'atypical hemolytic-uremic syndrome with MCP/CD46 anomaly', 'atypical hemolytic-uremic syndrome with I factor anomaly', 'atypical hemolytic-uremic syndrome with B factor anomaly', 'atypical hemolytic-uremic syndrome with C3 anomaly', 'atypical hemolytic-uremic syndrome with thrombomodulin anomaly', 'lymphoproliferative syndrome 1', 'purine nucleoside phosphorylase deficiency', 'spondylo-megaepiphyseal-metaphyseal dysplasia', 'brachydactylous dwarfism, Mseleni type', 'spondyloepimetaphyseal dysplasia, Handigodu type', 'hemolytic anemia due to glucophosphate isomerase deficiency', 'alpha 1-antitrypsin deficiency', 'occult macular dystrophy', 'papillary thyroid carcinoma', 'periodontitis', 'polycystic ovary syndrome', 'polyp', 'preeclampsia', 'prostate adenocarcinoma', 'psoriasis', 'renal cell carcinoma', 'respiratory system disease', 'sarcoma', 'severe acute respiratory syndrome', 'Sjogren syndrome', 'skin disease', 'small cell lung carcinoma', 'rheumatoid arthritis', 'spindle cell tumor', 'spondyloarthropathy', 'squamous cell carcinoma', 'squamous cell lung carcinoma', 'systemic scleroderma', 'ulcerative colitis', 'uterine fibroid', 'melanoma', 'malignant peripheral nerve sheath tumor', 'viral disease', 'HIV infection', 'AIDS', 'idiopathic pulmonary fibrosis', 'malignant pleural mesothelioma', 'bacterial disease', 'temporal lobe epilepsy', 'myositis', 'leprosy', 'celiac disease', 'cervical carcinoma', 'cytomegalovirus infection', 'Down syndrome', 'endometriosis', 'experimental autoimmune encephalomyelitis', 'parasitic infection', 'lung carcinoma', 'ovarian carcinoma', 'post-traumatic stress disorder', 'pulmonary arterial hypertension', 'synovial sarcoma', 'autosomal dominant polycystic liver disease', 'cerebral creatine deficiency syndrome', 'arterial disorder', 'glomerulosclerosis', 'small intestinal neuroendocrine tumor G1', 'breast benign neoplasm', 'central nervous system primitive neuroectodermal neoplasm', 'vertebral column disorder', 'cerebral cavernous malformation', 'interstitial emphysema', 'gastric cancer', 'essential hypertension', 'hypertensive heart disease', 'familial hyperlipidemia', 'impaired renal function disease', 'myopia', 'nephrocalcinosis', 'leiomyoma', 'prolapse of female genital organ', 'brain cancer', 'nontoxic goiter', 'pure red-cell aplasia', 'crescentic glomerulonephritis', 'tuberous sclerosis', 'depressive disorder', 'ventricular septal defect', 'pneumothorax', 'Richter syndrome', 'thyroid cancer', 'giant cell tumor', 'spondylosis', 'papilloma', 'kidney cancer', 'dermatitis', 'prostatic adenoma', 'lobular neoplasia', 'gingival overgrowth', 'papillary adenocarcinoma', 'digestive system cancer', 'inherited lipid metabolism disorder', 'skin squamous cell carcinoma', 'teratocarcinoma', 'teratoma', 'bone inflammation disease', 'small cell osteogenic sarcoma', 'cerebral infarction', 'liver cancer', 'uterine cancer', 'anal canal adenocarcinoma', 'skin cancer', 'cerebellar neoplasm', 'cervical cancer', 'breast angiosarcoma', 'bile duct adenocarcinoma', 'thoracic cancer', 'colonic disorder', 'functioning pituitary gland adenoma', 'anal canal squamous cell carcinoma', 'pancreatic intraductal papillary-mucinous neoplasm', 'muscular atrophy', 'female breast carcinoma', 'retinal degeneration', 'MHC class II deficiency 4', 'immunodeficiency 122', 'inflammation', 'circulating fibrinogen levels', 'glomerular filtration rate', 'fat pad mass', 'hip circumference', 'bone tissue density', 'von Willebrand factor quality', 'waist circumference', 'age of onset of asthma', 'level of serum globulin type protein', 'red blood cell density', 'serum alanine aminotransferase amount', 'heart rate', 'age of onset of allergic disease', 'brain volume', 'serum albumin amount', 'serum creatinine amount', 'body height', 'cyst', 'X-linked hyper-IgM syndrome', 'Brachydactyly - elbow wrist dysplasia', 'Chronic mucocutaneous candidosis', 'Desbuquois syndrome', 'Chédiak-Higashi syndrome', 'Recurrent infection due to specific granule deficiency', 'Immunodeficiency syndrome with autoimmunity', 'Metaphyseal chondrodysplasia, Schmid type', 'Åland Islands eye disease', 'Ichthyosis - intellectual disability - dwarfism - renal impairment', 'Autosomal recessive early-onset inflammatory bowel disease', 'X-linked lymphoproliferative disease', 'Metaphyseal dysostosis - intellectual disability - conductive deafness', 'CHST3-related skeletal dysplasia', 'Cyclic neutropenia', 'Severe combined immunodeficiency due to adenosine deaminase deficiency', 'Aneurysm - osteoarthritis syndrome', 'Rare disease with thoracic aortic aneurysm and aortic dissection', 'Multiple osteochondromas', 'Recurrent infections-myelofibrosis-nephromegaly syndrome', 'Acromesomelic dysplasia, Maroteaux type', 'Hyperlipoproteinemia type 1', 'X-linked agammaglobulinemia', 'Familial hemophagocytic lymphohistiocytosis', 'Immunodeficiency by defective expression of HLA class 2', 'Pyogenic arthritis - pyoderma gangrenosum - acne', 'Familial adenomatous polyposis', 'Thymic aplasia', 'Other metabolic disease', 'Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification', 'Hypohidrotic ectodermal dysplasia with immunodeficiency', 'Leukocyte adhesion deficiency type III', 'hematocrit', 'C-reactive protein measurement', 'glucose measurement', 'hemoglobin measurement', 'bone quantitative ultrasound measurement', 'triglyceride measurement', 'alkaline phosphatase measurement', 'creatine kinase measurement', 'cryptorchidism', 'total cholesterol measurement', 'gestational diabetes', 'low density lipoprotein cholesterol measurement', 'lymphocyte count', 'acute lung injury', 'high density lipoprotein cholesterol measurement', 'osteoarthritis, knee', 'cystatin C measurement', 'factor VII measurement', 'IGF-1 measurement', 'factor VIII measurement', 'white matter integrity', 'hip geometry', 'factor XI measurement', 'intraocular pressure measurement', 'sex hormone-binding globulin measurement', 'age at menarche', 'pelvic organ prolapse', 'FEV/FVC ratio', 'prion disease', 'aspartate aminotransferase measurement', 'protein measurement', 'neutrophil count', 'eosinophil count', 'lymph node metastatic carcinoma', 'appendicular lean mass', 'lumbar disc degeneration', 'lean body mass', 'type 2 diabetes nephropathy', 'autoimmune disease', 'congenital heart disease', 'central corneal thickness', 'cholangiocarcinoma', 'reading', 'anxiety', 'primitive neuroectodermal tumor', 'aortic valve calcification', 'non-small cell lung adenocarcinoma', 'axial length measurement', 'contact dermatitis', 'vein disorder', 'in situ carcinoma', 'inborn disorder of amino acid metabolism', 'allergic asthma', 'fatty liver disease', 'alopecia', 'hypoplastic left heart syndrome', 'Alzheimer disease', 'asthma', 'urinary bladder carcinoma', 'cancer', 'glaucoma', 'schizophrenia', 'upper respiratory tract disorder', 'type 1 diabetes mellitus', 'type 2 diabetes mellitus', 'pulmonary hypertension', 'osteoarthritis', 'Parkinson disease', 'pancreatic ductal adenocarcinoma', 'bacterial urinary tract infection', 'allergic disease', 'multiple sclerosis', 'skin basal cell carcinoma', 'childhood onset asthma', 'colorectal cancer', 'Lynch syndrome', 'Wilms tumor', 'prune belly syndrome', 'Adams-Oliver syndrome', 'Acropectorovertebral dysplasia', 'severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency', 'Tietz syndrome', 'autosomal dominant Alport syndrome', 'Townes-Brocks syndrome', 'atelosteogenesis type III', 'Osebold-Remondini syndrome', 'brachydactyly type C', 'autosomal dominant brachyolmia', 'Gordon syndrome', 'breast cancer', 'chondrocalcinosis 2', 'congenital contractural arachnodactyly', 'fleck corneal dystrophy', 'Duane retraction syndrome', 'Leri-Weill dyschondrosteosis', 'Beckwith-Wiedemann syndrome', 'esophageal cancer', 'autoinflammatory syndrome, familial, X-linked, Behcet-like 2', 'immunodeficiency 98 with autoinflammation, X-linked', 'metastatic malignant neoplasm', 'granulomatous disease, chronic, autosomal recessive, 5', 'hyper-IgE recurrent infection syndrome 5, autosomal recessive', 'immunodeficiency 81', 'immunodeficiency 82 with systemic inflammation', 'inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive', 'immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias', 'immunodeficiency 75', 'immunodeficiency 76', 'nephrotic syndrome 16', 'immunodeficiency 69', 'immunodeficiency 78 with autoimmunity and developmental delay', 'immunodeficiency 70', 'immunodeficiency 72 with autoinflammation', 'immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia', 'autoinflammation, immune dysregulation, and eosinophilia', 'severe combined immunodeficiency due to CD70 deficiency', 'myofibroblastoma', 'invasive carcinoma', 'adenoviridae infectious disease', 'brain injury', 'nosocomial infection', 'enteritis', 'ulcer disease', 'radiation pneumonitis', 'familial adenomatous polyposis 4', 'severe combined immunodeficiency due to LAT deficiency', 'desmoplastic melanoma', 'myelofibrosis', 'salivary duct carcinoma', 'oral cavity carcinoma', 'rectal carcinoma', 'vertebral disorder', 'digestive system melanoma', 'short-rib thoracic dysplasia 17 with or without polydactyly', 'platelet abnormalities with eosinophilia and immune-mediated inflammatory disease', 'COVID-19', 'liver failure', 'COVID-19–associated multisystem inflammatory syndrome in adults', 'disease arising from reactivation of latent virus', 'Friedreich ataxia', 'malignant glioma', 'spondyloepimetaphyseal dysplasia', 'gastrointestinal defects and immunodeficiency syndrome 1', 'immunodeficiency 105', 'autoinflammatory disease, X-linked', 'autoinflammatory syndrome with immunodeficiency', 'achalasia-alacrima syndrome', 'choroidal neovascularization', 'rhizomelic dysplasia, Ain-Naz type', 'autoinflammatory disease, multisystem, with immune dysregulation, X-linked', 'hyper-IgE syndrome 6, autosomal dominant, with recurrent infections', 'immunodeficiency 113 with autoimmunity and autoinflammation', 'immunodeficiency 117', 'neutropenia, severe congenital, 11, autosomal dominant', 'autoinflammation with episodic fever and immune dysregulation', 'immunodeficiency 119', 'postmenopausal osteoporosis', 'dissection', 'uterine neoplasm', 'pancreatic neoplasm', 'kidney neoplasm', 'brain aneurysm', 'colitis', 'osteoporosis', 'chronic kidney disease', 'ovarian neoplasm', 'acne', 'ankylosing spondylitis', 'deep vein thrombosis', 'angina pectoris', 'atherosclerosis', 'necrotizing enterocolitis', 'gastroesophageal reflux disease', 'seasonal allergic rhinitis', 'breast neoplasm', 'left ventricular hypertrophy', 'stomach neoplasm', 'obstructive sleep apnea', 'relapsing-remitting multiple sclerosis', 'angiosarcoma', 'colorectal neoplasm', 'neuropathy', 'open-angle glaucoma', 'basal cell carcinoma', 'IGA glomerulonephritis', 'hepatitis B virus infection', 'skin neoplasm', 'Vitiligo', 'hypospadias', 'Keloid', 'Abdominal Aortic Aneurysm', 'chronic hepatitis C virus infection', 'eosinophilic esophagitis', 'exfoliation syndrome', 'focal segmental glomerulosclerosis', 'chronic hepatitis B virus infection', 'interstitial lung disease', 'mucocutaneous lymph node syndrome', 'meningococcal infection', 'membranous glomerulonephritis', 'nephrotic syndrome', 'osteonecrosis', 'bone disease', 'vascular disease', 'peripheral arterial disease', 'sclerosing cholangitis', 'scoliosis', 'brain infarction', 'thoracic aortic aneurysm', 'ventricular fibrillation', 'colonic neoplasm', 'erythrocyte count', 'platelet count', 'vital capacity', 'forced expiratory volume', 'smoking behavior', 'body weight', 'body mass index', 'body fat distribution', 'waist-hip ratio', 'corneal topography', 'neuroimaging measurement', 'metastatic neoplasm', 'wheezing', 'enthesitis-related juvenile idiopathic arthritis', 'Chronic Obstructive Asthma', 'carotid atherosclerosis', 'pulse wave reflection index measurement', 'total hip arthroplasty', 'kidney injury', 'muscle atrophy', 'chromosomal aberration frequency', 'bone metastasis', 'HMG CoA reductase inhibitor use measurement', 'Inhalant adrenergic use measurement', 'Glucocorticoid use measurement', 'low density lipoprotein triglyceride measurement', 'diverticular disease', 'corneal resistance factor', 'citrate measurement', 'cholesteryl ester measurement', 'glucuronate measurement', 'isocitrate measurement', 'atopic asthma', 'coinfection', 'total joint arthroplasty', 'aspartate aminotransferase to alanine aminotransferase ratio', 'nephrotoxicity', 'inflammatory bowel disease, immunodeficiency, and encephalopathy', 'severe malarial anemia', 'total knee arthroplasty', 'palmitate 16:0 measurement', 'sexual dimorphism measurement', 'body surface area', 'serum lipopolysaccharide activity', 'Birt-Hogg-Dube syndrome', '25-hydroxyvitamin D3 measurement', 'cecum adenocarcinoma', 'chronic rhinosinusitis', 'cystitis', 'granulosa cell tumor', 'ovarian clear cell adenocarcinoma', 'pancreatic adenocarcinoma', 'pancreatic neuroendocrine tumor', 'pulmonary tuberculosis', 'tongue squamous cell carcinoma', 'nasopharyngeal squamous cell carcinoma', 'Acute Leukemia', 'Ampulla of Vater Carcinoma', 'Appendix Adenocarcinoma', 'Atrophy', 'Atypical Meningioma', 'Bladder Small Cell Neuroendocrine Carcinoma', 'Cavernous Hemangioma', 'Central Nervous System Lymphoma', 'Cervical Adenosquamous Carcinoma', 'cervical squamous cell carcinoma', 'Colon Dysplasia', 'Duodenal Adenocarcinoma', 'Endometrial Clear Cell Adenocarcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Endometrial Undifferentiated Carcinoma', 'Fibroblastic Neoplasm', 'hereditary diffuse gastric adenocarcinoma', 'Holt-Oram syndrome', 'Huntington disease', 'nonpapillary renal cell carcinoma', 'Pallister-Hall syndrome', 'periodic fever, immunodeficiency, and thrombocytopenia syndrome', 'platyspondylic dysplasia, Torrance type', 'systemic lupus erythematosus', 'Marfan syndrome', 'melorheostosis', 'mesomelic dysplasia, Kantaputra type', 'metatropic dysplasia', 'Mobius syndrome', 'Muir-Torre syndrome', 'Cowden syndrome 1', 'myotonic dystrophy type 1', 'nail-patella syndrome', 'autosomal dominant progressive nephropathy with hypertension', 'ovarian cancer', 'Peyronie disease', 'polyostotic fibrous dysplasia', 'juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome', 'Hutchinson-Gilford progeria syndrome', 'familial juvenile hyperuricemic nephropathy type 1', 'Peutz-Jeghers syndrome', 'prostate cancer', 'pseudoachondroplasia', 'autosomal dominant distal renal tubular acidosis', 'retinoblastoma', 'Smith-Magenis syndrome', 'spondyloepiphyseal dysplasia tarda, autosomal dominant', 'spondyloepimetaphyseal dysplasia, Strudwick type', 'spondylometaphyseal dysplasia, Kozlowski type', 'spondylometaphyseal dysplasia, Schmidt type', 'proximal symphalangism', 'syndactyly type 5', 'brachydactyly-elbow wrist dysplasia syndrome', 'tarsal-carpal coalition syndrome', 'thoracolaryngopelvic dysplasia', 'tooth and nail syndrome', 'volvulus of midgut', 'short-limb skeletal dysplasia with severe combined immunodeficiency', 'acrocallosal syndrome', 'acrodermatitis enteropathica', 'acromesomelic dysplasia 2C, Hunter-Thompson type', 'agnathia-otocephaly complex', 'autosomal recessive Alport syndrome', 'amelogenesis imperfecta type 1G', 'microphthalmia with limb anomalies', 'progressive pseudorheumatoid arthropathy of childhood', 'Bloom syndrome', 'kyphomelic dysplasia', 'lung cancer', 'heart defects-limb shortening syndrome', 'chordoma', 'Juberg-Hayward syndrome', 'Costello syndrome', 'cystic fibrosis', 'hereditary renal hypouricemia', 'diastrophic dysplasia', 'Dyggve-Melchior-Clausen disease', 'Ehlers-Danlos syndrome, dermatosparaxis type', 'multiple epiphyseal dysplasia type 4', 'classic Hodgkin lymphoma', 'immunodeficiency, common variable, 2', 'ichthyosis-intellectual disability-dwarfism-renal impairment syndrome', 'Nezelof syndrome', 'spondylometaphyseal dysplasia, Sedaghatian type', 'metaphyseal dysostosis-intellectual disability-conductive deafness syndrome', 'Nijmegen breakage syndrome', 'Miyoshi myopathy', 'carnitine palmitoyl transferase II deficiency, myopathic form', 'Schwartz-Jampel syndrome', 'Leigh syndrome', 'nail-patella-like renal disease', 'nephronophthisis 1', 'congenital nephrotic syndrome, Finnish type', 'multiple myeloma', 'cervical adenocarcinoma', 'liver disease', 'cirrhosis of liver', 'lymphoid neoplasm', 'coronary artery disease', 'prostate carcinoma', 'aortic aneurysm', 'human papilloma virus infection', 'fibrosarcoma', 'benign neoplasm', 'hypertrophy', 'anaplastic astrocytoma', 'cardiac hypertrophy', 'medical procedure', 'AIDS dementia', 'juvenile idiopathic arthritis', 'insulin resistance', 'prostate intraepithelial neoplasia', 'septic peritonitis', 'vulvar intraepithelial neoplasia', 'renal carcinoma', 'thyroid carcinoma', 'metastatic melanoma', 'pancreatic carcinoma', 'rotavirus infection', 'Cutaneous T-cell lymphoma', 'ovarian serous adenocarcinoma', 'rhabdomyosarcoma', 'medulloblastoma', 'muscular disease', 'transitional cell carcinoma of kidney', 'anaplastic large cell lymphoma', 'bacteriemia', 'hepatitis C virus infection', 'non-small cell lung carcinoma', 'kidney disease', 'non-alcoholic fatty liver disease', 'peripheral neuropathy', 'testicular seminoma', 'pneumonia', 'heart failure', 'vitamin D deficiency', 'inflammatory bowel disease', 'diabetic retinopathy', 'heart disease', 'psoriatic arthritis', 'refractory anemia with ringed sideroblasts', 'laryngeal neoplasm', 'lung disease', 'brain neoplasm', 'calcification', 'retinopathy', 'thyroid neoplasm'], tissue_specific_expression={'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\"small intestine Peyer's patch\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}, is_essential=False, genetic_constraint={'syn': -0.12650999426841736, 'mis': 4.360300064086914, 'lof': 0.9999799728393555}, pharmacovigilance=[]), transcriptome=TranscriptomeProfile(transcripts={}, isoforms={'general_localization': {'name': 'general_localization', 'aliases': [], 'status': None, 'locations': ['Cytoplasm', 'Nucleus'], 'notes': ['Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)']}}, avg_exons_per_transcript=None, transcript_count=0, total_exon_count=None, median_transcript_span_bp=None, max_transcript_span_bp=None), gwas_profile=None, variants={}, traits=[], binding_peaks={}, mirna_targets={}, alliancegenome_info=[], viral_interactions=[], text_summaries_from_tools=['*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0', '*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.', '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00', '*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.', \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\", '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.', '*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn\\\\'s disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'breast\\\\': 0, \\\\'atrium auricular region\\\\': 1, \\\\'liver\\\\': 0, \\\\'skeletal muscle tissue\\\\': 1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\\'esophagus mucosa\\\\': 1, \\\\'macrophage\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'segmented neutrophil of bone marrow\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': -1, \\\\'class switched memory B cell\\\\': 0, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 3, \\\\'Brodmann (1909) area 9\\\\': 0, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 1, \\\\'zone of skin\\\\': 1, \\\\'leukocyte\\\\': 0, \\\\'nasopharynx\\\\': -1, \\\\'tonsil\\\\': 0, \\\\'frontal lobe\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'putamen\\\\': 0, \\\\'hematopoietic stem cell\\\\': -1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'testis\\\\': -1, \\\\'bronchus\\\\': -1, \\\\'sigmoid colon\\\\': 0, \\\\'fallopian tube\\\\': 0, \\\\'plasma cell\\\\': -1, \\\\'aorta\\\\': 0, \\\\'adrenal gland\\\\': -1, \\\\'kidney\\\\': 0, \\\\'endometrium\\\\': 0, \\\\'smooth muscle tissue\\\\': 0, \\\\'tibial artery\\\\': 0, \\\\'prefrontal cortex\\\\': 0, \\\\'CD8-positive, alpha-beta T cell\\\\': -1, \\\\'vermiform appendix\\\\': 0, \\\\'lymph node\\\\': 0, \\\\'duodenum\\\\': 0, \\\\'mature eosinophil\\\\': 0, \\\\'prostate gland\\\\': 1, \\\\'C1 segment of cervical spinal cord\\\\': -1, \\\\'lung\\\\': 0, \\\\'inflammatory macrophage\\\\': -1, \\\\'rectum\\\\': 0, \\\\'suprapubic skin\\\\': 0, \\\\'brain\\\\': -1, \\\\'coronary artery\\\\': 0, \\\\'parathyroid gland\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': 0, \\\\'esophagus muscularis mucosa\\\\': 0, \\\\'esophagus\\\\': 1, \\\\'transformed skin fibroblast\\\\': 1, \\\\'heart muscle\\\\': -1, \\\\'pancreas\\\\': 0, \\\\'uterus\\\\': 0, \\\\'placenta\\\\': 0, \\\\'seminal vesicle\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'endothelial cell of umbilical vein (resting)\\\\': 0, \\\\'minor salivary gland\\\\': 0, \\\\'endocervix\\\\': 1, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'CD8-positive, alpha-beta thymocyte\\\\': -1, \\\\'granulocyte monocyte progenitor cell\\\\': -1, \\\\'caudate nucleus\\\\': 0, \\\\'amygdala\\\\': 0, \\\\'temporal lobe\\\\': 0, \\\\'substantia nigra\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'common lymphoid progenitor\\\\': 0, \\\\'cerebral cortex\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 0, \\\\'blood\\\\': -1, \\\\'nucleus accumbens\\\\': 0, \\\\'stomach\\\\': 0, \\\\'oral mucosa\\\\': -1, \\\\'mature neutrophil\\\\': 0, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'bone marrow\\\\': -1, \\\\'gall bladder\\\\': 1, \\\\'colon\\\\': 0, \\\\'cytotoxic CD56-dim natural killer cell\\\\': -1, \\\\'pituitary gland\\\\': 0, \\\\'transverse colon\\\\': 0, \\\\'heart left ventricle\\\\': 0, \\\\'erythroblast\\\\': -1, \\\\'vagina\\\\': 1, \\\\'ovary\\\\': 1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': 1, \\\\'cerebellum\\\\': -1, \\\\'hypothalamus\\\\': -1, \\\\'common myeloid progenitor\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': -1, \\\\'alternatively activated macrophage\\\\': -1, \\\\'thyroid gland\\\\': 1, \\\\'lower leg skin\\\\': 0, \\\\'epididymis\\\\': -1, \\\\'spleen\\\\': 0, \\\\'esophagogastric junction\\\\': 0, \\\\'greater omentum\\\\': 1, \\\\'memory B cell\\\\': 0, \\\\'hippocampus proper\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': -1, \\\\'small intestine\\\\': 1, \\\\'conventional dendritic cell\\\\': -1, \\\\'cortex of kidney\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": 0, \\\\'heart\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': -1, \\\\'caudate-putamen\\\\': -1, \\\\'urinary bladder\\\\': 1, \\\\'ectocervix\\\\': 1, \\\\'regulatory T cell\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 1, \\\\'saliva-secreting gland\\\\': 0, \\\\'neutrophilic metamyelocyte\\\\': -1, \\\\'tibial nerve\\\\': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don\\\\'t change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555'], tools_run=['EntityExtraction', 'MSigDB', 'uniprot_entry', 'BioGRID', 'OpenTargets', 'reactome_pathways', 'humanbase_predictions'])}, 'variant_entities': {}, 'drug_entities': {}, 'context_block': '', 'llm_json': {}, 'tool_updates': 2, 'used_tools': ['BioGRID', 'MSigDB', 'chembl', 'drug_central', 'extract_entities', 'prot', 'uniprot_base'], 'use_tools': ['extract_entities', 'prot', 'chembl', 'drug_central', 'MSigDB', 'uniprot_base', 'BioGRID', 'OpenTargets', 'reactome', 'humanbase_functions', 'Summarize_GO'], 'ui': {}, 'prot_html': '\\\\n\\\\n\\\\n \\\\n Protein Viewer - SMAD2, SMAD3\\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n \\\\n \\\\n\\\\n\\\\n\\\\n \\\\n
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    \\\\n\\\\n\\\\n', 'drug_central_html': '', 'aa_seq_html': '', 'text_notes': []}\\n[TOOL RUN] → Summarize_GO\\nFetching UniProt entry for gene: SMAD2\\nUNIPROT RESULTS [{'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'Q15796', 'uniProtkbId': 'SMAD2_HUMAN', 'entryAudit': {'firstPublicDate': '2001-04-27', 'lastAnnotationUpdateDate': '2025-06-18', 'lastSequenceUpdateDate': '1996-11-01', 'entryVersion': 253, 'sequenceVersion': 1}, 'annotationScore': 5.0, 'organism': {'scientificName': 'Homo sapiens', 'commonName': 'Human', 'taxonId': 9606, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Mothers against decapentaplegic homolog 2'}, 'shortNames': [{'value': 'MAD homolog 2'}, {'value': 'Mothers against DPP homolog 2'}]}, 'alternativeNames': [{'fullName': {'value': 'JV18-1'}}, {'fullName': {'value': 'Mad-related protein 2'}, 'shortNames': [{'value': 'hMAD-2'}]}, {'fullName': {'value': 'SMAD family member 2'}, 'shortNames': [{'value': 'SMAD 2'}, {'value': 'Smad2'}, {'value': 'hSMAD2'}]}]}, 'genes': [{'geneName': {'value': 'SMAD2'}, 'synonyms': [{'value': 'MADH2'}, {'value': 'MADR2'}]}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': 'Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed:8752209)'}], 'commentType': 'FUNCTION'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10615055'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10835638'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11278756'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11387212'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11389444'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15350224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15647271'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16200078'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751102'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17099224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17292623'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18568018'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19049980'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24324267'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24627487'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25105025'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9670020'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9702198'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}, {'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '20061380'}], 'value': \\\"Monomer; in the absence of TGF-beta (PubMed:9670020). Heterodimer; in the presence of TGF-beta (PubMed:9670020). Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4 (PubMed:15350224, PubMed:24324267, PubMed:9670020). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta (PubMed:16751102). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (PubMed:24324267). Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD (PubMed:10615055). Interacts with TAZ/WWRT1 (PubMed:18568018). Interacts with FOXH1 (PubMed:9702198). Interacts with SNW1 (PubMed:11278756). Interacts with CREB-binding protein (CBP) and EP300 (PubMed:16862174). Interacts with SNON (PubMed:11389444). Interacts with ALK4/ACVR1B (PubMed:10615055, PubMed:9892009). Interacts with SKOR1 (PubMed:17292623). Interacts with SKOR2 (PubMed:16200078). Interacts with PRDM16 (PubMed:19049980). Interacts (via MH2 domain) with LEMD3 (PubMed:15601644, PubMed:15647271). Interacts with RBPMS (PubMed:17099224). Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (PubMed:19289081). Interacts with PDPK1 (via PH domain) (PubMed:17327236). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (PubMed:11387212). Interacts with USP15 (PubMed:21947082). Interacts with PPP5C (PubMed:22781750). Interacts with LDLRAD4 (via the SMAD interaction motif) (PubMed:24627487). Interacts (via MH2 domain) with PMEPA1 (via the SMAD interaction motif) (PubMed:20129061). Interacts with ZFHX3 (PubMed:25105025). Interacts with ZNF451 (PubMed:24324267). Interacts with SMURF2 when phosphorylated on Ser-465/467 (PubMed:11389444). Interacts with PPM1A (PubMed:16751101). Interacts with TGF-beta (PubMed:8980228). Interacts with TGFBR1 (PubMed:9865696). Interacts with TGIF (PubMed:10835638). Interacts with SMAD3 and TRIM33 (PubMed:16751102). Interacts with ZNF580 (PubMed:21599657). Interacts with NEDD4L in response to TGF-beta (By similarity). Interacts with HGS (By similarity). Interacts with AIP1 (By similarity). Interacts with WWP1 (By similarity). Interacts with PML (By similarity). Interacts weakly with ZNF8 (By similarity). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD2 inhibitors (By similarity). Interacts with YAP1 (when phosphorylated at 'Ser-127') (By similarity). Interacts when phosphorylated with IPO7; the interaction facilitates translocation of SMAD2 to the nucleus (By similarity). Interacts with MTMR4; negatively regulates TGF-beta signaling through SMAD2 dephosphorylation and retention in endosomes (Probable)\\\"}], 'commentType': 'SUBUNIT'}, {'commentType': 'INTERACTION', 'interactions': [{'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q12955', 'geneName': 'ANK3', 'intActId': 'EBI-2691178'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P05060', 'geneName': 'CHGB', 'intActId': 'EBI-712619'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O15111', 'geneName': 'CHUK', 'intActId': 'EBI-81249'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P98082', 'geneName': 'DAB2', 'intActId': 'EBI-1171238'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZ29', 'geneName': 'DOCK9', 'intActId': 'EBI-2695893'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O75593', 'geneName': 'FOXH1', 'intActId': 'EBI-1759806'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P05412', 'geneName': 'JUN', 'intActId': 'EBI-852823'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9NYA4', 'geneName': 'MTMR4', 'intActId': 'EBI-1052346'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P07197', 'geneName': 'NEFM', 'intActId': 'EBI-1105035'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q8TAK6', 'geneName': 'OLIG1', 'intActId': 'EBI-3867416'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P35813', 'geneName': 'PPM1A', 'intActId': 'EBI-989143'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H6Z4', 'geneName': 'RANBP3', 'intActId': 'EBI-992681'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P61586', 'geneName': 'RHOA', 'intActId': 'EBI-446668'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P12755', 'geneName': 'SKI', 'intActId': 'EBI-347281'}, 'numberOfExperiments': 11, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P12757', 'geneName': 'SKIL', 'intActId': 'EBI-2902468'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q15796', 'geneName': 'SMAD2', 'intActId': 'EBI-1040141'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P84022', 'geneName': 'SMAD3', 'intActId': 'EBI-347161'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q13485', 'geneName': 'SMAD4', 'intActId': 'EBI-347263'}, 'numberOfExperiments': 24, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9HAU4', 'geneName': 'SMURF2', 'intActId': 'EBI-396727'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q13573', 'geneName': 'SNW1', 'intActId': 'EBI-632715'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P04637', 'geneName': 'TP53', 'intActId': 'EBI-366083'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H3D4', 'geneName': 'TP63', 'intActId': 'EBI-2337775'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q9UPN9', 'geneName': 'TRIM33', 'intActId': 'EBI-2214398'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O00308', 'geneName': 'WWP2', 'intActId': 'EBI-743923'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'Q96KR1', 'geneName': 'ZFR', 'intActId': 'EBI-2513582'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'O95405', 'geneName': 'ZFYVE9', 'intActId': 'EBI-296817'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'Q15796', 'intActId': 'EBI-1040141'}, 'interactantTwo': {'uniProtKBAccession': 'P70056', 'geneName': 'foxh1', 'intActId': 'EBI-9969973'}, 'numberOfExperiments': 4, 'organismDiffer': True}]}, {'commentType': 'SUBCELLULAR LOCATION', 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 (PubMed:21145499, PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)'}]}, 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Cytoplasm', 'id': 'SL-0086'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}], 'value': 'Nucleus', 'id': 'SL-0191'}}]}, {'commentType': 'ALTERNATIVE PRODUCTS', 'events': ['Alternative splicing'], 'isoforms': [{'name': {'value': 'Long'}, 'isoformIds': ['Q15796-1'], 'isoformSequenceStatus': 'Displayed'}, {'name': {'value': 'Short'}, 'synonyms': [{'value': 'Smad2Deltaexon3'}], 'isoformIds': ['Q15796-2'], 'sequenceIds': ['VSP_006178'], 'isoformSequenceStatus': 'Described'}]}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21599657'}], 'value': 'Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta'}], 'commentType': 'TISSUE SPECIFICITY'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11879191'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12193595'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}], 'value': 'Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q62432'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'value': \\\"In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding (By similarity). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover (By similarity)\\\"}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}], 'value': 'Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. Isoform short: Acetylation increases DNA binding activity in vitro and enhances its association with target promoters in vivo. Acetylation in the nucleus by EP300 is enhanced by TGF-beta'}], 'commentType': 'PTM'}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Congenital heart defects, multiple types, 8, with or without heterotaxy', 'diseaseAccession': 'DI-06292', 'acronym': 'CHTD8', 'description': 'An autosomal dominant disorder characterized by congenital developmental abnormalities involving structures of the heart. Common CHTD8 features include double-outlet right ventricle, unbalanced complete atrioventricular canal, and valvular anomalies. Vascular anomalies include dextroposition of the great arteries, anomalous pulmonary venous return, and superior vena cava to left atrium defect. Patients may also exhibit laterality defects, including dextrocardia, atrial isomerism, dextrogastria, left-sided gallbladder, and intestinal malrotation.', 'diseaseCrossReference': {'database': 'MIM', 'id': '619657'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23665959'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Loeys-Dietz syndrome 6', 'diseaseAccession': 'DI-06280', 'acronym': 'LDS6', 'description': 'A form of Loeys-Dietz syndrome, a syndrome with widespread systemic involvement characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Most LDS6 patients have thoracic aortic aneurysm involving the ascending aorta and/or aortic root, but cerebral and iliac arteries can be affected, and abdominal aortic aneurysm has been observed. Arterial tortuosity involving cerebral vessels, the aorta, and/or iliac arteries has also been reported. LDS6 inheritance is autosomal dominant.', 'diseaseCrossReference': {'database': 'MIM', 'id': '619656'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28283438'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Belongs to the dwarfin/SMAD family'}], 'commentType': 'SIMILARITY'}, {'commentType': 'WEB RESOURCE', 'resourceName': 'Atlas of Genetics and Cytogenetics in Oncology and Haematology', 'resourceUrl': 'https://atlasgeneticsoncology.org/gene/370/SMAD2', 'ftp': False}], 'features': [{'type': 'Initiator methionine', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 1, 'modifier': 'EXACT'}}, 'description': 'Removed', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22223895'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Chain', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Mothers against decapentaplegic homolog 2', 'featureId': 'PRO_0000090852'}, {'type': 'Domain', 'location': {'start': {'value': 10, 'modifier': 'EXACT'}, 'end': {'value': 176, 'modifier': 'EXACT'}}, 'description': 'MH1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00438'}]}, {'type': 'Domain', 'location': {'start': {'value': 274, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'MH2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Region', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 251, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Motif', 'location': {'start': {'value': 221, 'modifier': 'EXACT'}, 'end': {'value': 225, 'modifier': 'EXACT'}}, 'description': 'PY-motif'}, {'type': 'Compositional bias', 'location': {'start': {'value': 207, 'modifier': 'EXACT'}, 'end': {'value': 217, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Compositional bias', 'location': {'start': {'value': 233, 'modifier': 'EXACT'}, 'end': {'value': 243, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Binding site', 'location': {'start': {'value': 74, 'modifier': 'EXACT'}, 'end': {'value': 74, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 149, 'modifier': 'EXACT'}, 'end': {'value': 149, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 161, 'modifier': 'EXACT'}, 'end': {'value': 161, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 166, 'modifier': 'EXACT'}, 'end': {'value': 166, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Modified residue', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 2, 'modifier': 'EXACT'}}, 'description': 'N-acetylserine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.7'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22223895'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by MAPK3', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12193595'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18691976'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 19, 'modifier': 'EXACT'}, 'end': {'value': 19, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 220, 'modifier': 'EXACT'}, 'end': {'value': 220, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 240, 'modifier': 'EXACT'}, 'end': {'value': 240, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CAMK2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11879191'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 245, 'modifier': 'EXACT'}, 'end': {'value': 245, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 250, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 255, 'modifier': 'EXACT'}, 'end': {'value': 255, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '12193595'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 458, 'modifier': 'EXACT'}, 'end': {'value': 458, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18669648'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 460, 'modifier': 'EXACT'}, 'end': {'value': 460, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '20068231'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 464, 'modifier': 'EXACT'}, 'end': {'value': 464, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23478445'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9136927'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9346908'}]}, {'type': 'Alternative sequence', 'location': {'start': {'value': 79, 'modifier': 'EXACT'}, 'end': {'value': 108, 'modifier': 'EXACT'}}, 'description': 'in isoform Short', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'featureId': 'VSP_006178', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 133, 'modifier': 'EXACT'}, 'end': {'value': 133, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011375', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 159, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}], 'featureId': 'VAR_086573', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 274, 'modifier': 'EXACT'}, 'end': {'value': 274, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '23665959'}], 'featureId': 'VAR_086574', 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 278, 'modifier': 'EXACT'}, 'end': {'value': 278, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '28283438'}], 'featureId': 'VAR_086575', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 300, 'modifier': 'EXACT'}, 'end': {'value': 300, 'modifier': 'EXACT'}}, 'description': 'in a colorectal cancer sample; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}], 'featureId': 'VAR_036473', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 312, 'modifier': 'EXACT'}, 'end': {'value': 312, 'modifier': 'EXACT'}}, 'description': 'in CHTD8', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '30157302'}], 'featureId': 'VAR_086576', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 318, 'modifier': 'EXACT'}, 'end': {'value': 318, 'modifier': 'EXACT'}}, 'description': 'found in a patient with Marfan syndrome-like phenotype; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086577', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 344, 'modifier': 'EXACT'}, 'end': {'value': 358, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8673135'}], 'featureId': 'VAR_011376', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 361, 'modifier': 'EXACT'}, 'end': {'value': 361, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086578', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 388, 'modifier': 'EXACT'}, 'end': {'value': 388, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}], 'featureId': 'VAR_086579', 'alternativeSequence': {'originalSequence': 'Q', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 397, 'modifier': 'EXACT'}, 'end': {'value': 397, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086580', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 440, 'modifier': 'EXACT'}, 'end': {'value': 440, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011377', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 445, 'modifier': 'EXACT'}, 'end': {'value': 445, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011378', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['H']}}, {'type': 'Natural variant', 'location': {'start': {'value': 449, 'modifier': 'EXACT'}, 'end': {'value': 449, 'modifier': 'EXACT'}}, 'description': 'in LDS6; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}], 'featureId': 'VAR_086581', 'alternativeSequence': {'originalSequence': 'L', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 450, 'modifier': 'EXACT'}, 'end': {'value': 450, 'modifier': 'EXACT'}}, 'description': 'in a colorectal carcinoma sample', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8752209'}], 'featureId': 'VAR_011379', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 457, 'modifier': 'EXACT'}, 'end': {'value': 457, 'modifier': 'EXACT'}}, 'description': 'in LDS6', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26247899'}], 'featureId': 'VAR_086582', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'found in a patient suspected to suffer from Marfan syndrome; uncertain significance', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29967133'}], 'featureId': 'VAR_086583', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['L']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 19, 'modifier': 'EXACT'}, 'end': {'value': 19, 'modifier': 'EXACT'}}, 'description': 'Loss of acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 20, 'modifier': 'EXACT'}, 'end': {'value': 20, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17074756'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 221, 'modifier': 'EXACT'}, 'end': {'value': 225, 'modifier': 'EXACT'}}, 'description': 'Loss of binding to SMURF2.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11389444'}], 'alternativeSequence': {}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 368, 'modifier': 'EXACT'}, 'end': {'value': 368, 'modifier': 'EXACT'}}, 'description': 'Loss of interaction with PMEPA1.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}], 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 381, 'modifier': 'EXACT'}, 'end': {'value': 381, 'modifier': 'EXACT'}}, 'description': 'Loss of binding to SARA.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10615055'}], 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['S']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 398, 'modifier': 'EXACT'}, 'end': {'value': 398, 'modifier': 'EXACT'}}, 'description': 'Increased binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}], 'alternativeSequence': {'originalSequence': 'V', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 464, 'modifier': 'EXACT'}, 'end': {'value': 464, 'modifier': 'EXACT'}}, 'description': 'Loss of phosphorylation by TGFBR1; when associated with A-465 and A-467.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Binds RANBP3.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}], 'alternativeSequence': {'originalSequence': 'SMS', 'alternativeSequences': ['AMA']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced RANBP2 binding.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}], 'alternativeSequence': {'originalSequence': 'SMS', 'alternativeSequences': ['DMD']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A. Loss of phosphorylation by TGFBR1; when associated with A-464 and A-467.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 465, 'modifier': 'EXACT'}, 'end': {'value': 465, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A. Loss of phosphorylation by TGFBR1; when associated with A-464 and A-465.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 467, 'modifier': 'EXACT'}, 'end': {'value': 467, 'modifier': 'EXACT'}}, 'description': 'No change in binding to PPM1A.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8980228'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Beta strand', 'location': {'start': {'value': 264, 'modifier': 'EXACT'}, 'end': {'value': 267, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0007829', 'source': 'PDB', 'id': '1DEV'}]}, {'type': 'Beta strand', 'location': {'start': 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'16806156'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9111321'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9732876'}]}, {'database': 'GO', 'id': 'GO:0007179', 'properties': [{'key': 'GoTerm', 'value': 'P:transforming growth factor beta receptor signaling pathway'}, {'key': 'GoEvidenceType', 'value': 'IDA:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '18548003'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '8752209'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9389648'}, {'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '9732876'}]}, {'database': 'GO', 'id': 'GO:0061450', 'properties': [{'key': 'GoTerm', 'value': 'P:trophoblast cell migration'}, {'key': 'GoEvidenceType', 'value': 'IDA:UniProt'}], 'evidences': [{'evidenceCode': 'ECO:0000314', 'source': 'PubMed', 'id': '34432647'}]}, {'database': 'GO', 'id': 'GO:0001657', 'properties': [{'key': 'GoTerm', 'value': 'P:ureteric bud development'}, {'key': 'GoEvidenceType', 'value': 'IEA:Ensembl'}]}, {'database': 'GO', 'id': 'GO:0007352', 'properties': [{'key': 'GoTerm', 'value': 'P:zygotic specification of dorsal/ventral axis'}, {'key': 'GoEvidenceType', 'value': 'IMP:BHF-UCL'}], 'evidences': [{'evidenceCode': 'ECO:0000315', 'source': 'PubMed', 'id': '9436979'}]}, {'database': 'CDD', 'id': 'cd10491', 'properties': [{'key': 'EntryName', 'value': 'MH1_SMAD_2_3'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'CDD', 'id': 'cd10985', 'properties': [{'key': 'EntryName', 'value': 'MH2_SMAD_2_3'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'DisProt', 'id': 'DP01319', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'FunFam', 'id': '2.60.200.10:FF:000001', 'properties': [{'key': 'EntryName', 'value': 'Mothers against decapentaplegic homolog'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'FunFam', 'id': '3.90.520.10:FF:000007', 'properties': [{'key': 'EntryName', 'value': 'Mothers against decapentaplegic homolog'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Gene3D', 'id': '2.60.200.10', 'properties': [{'key': 'EntryName', 'value': '-'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Gene3D', 'id': '3.90.520.10', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'IDEAL', 'id': 'IID00127', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'InterPro', 'id': 'IPR013790', 'properties': [{'key': 'EntryName', 'value': 'Dwarfin'}]}, {'database': 'InterPro', 'id': 'IPR003619', 'properties': [{'key': 'EntryName', 'value': 'MAD_homology1_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR013019', 'properties': [{'key': 'EntryName', 'value': 'MAD_homology_MH1'}]}, {'database': 'InterPro', 'id': 'IPR017855', 'properties': [{'key': 'EntryName', 'value': 'SMAD-like_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR001132', 'properties': [{'key': 'EntryName', 'value': 'SMAD_dom_Dwarfin-type'}]}, {'database': 'InterPro', 'id': 'IPR008984', 'properties': [{'key': 'EntryName', 'value': 'SMAD_FHA_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR036578', 'properties': [{'key': 'EntryName', 'value': 'SMAD_MH1_sf'}]}, {'database': 'PANTHER', 'id': 'PTHR13703:SF42', 'properties': [{'key': 'EntryName', 'value': 'MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PANTHER', 'id': 'PTHR13703', 'properties': [{'key': 'EntryName', 'value': 'SMAD'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03165', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03166', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00523', 'properties': [{'key': 'EntryName', 'value': 'DWA'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00524', 'properties': [{'key': 'EntryName', 'value': 'DWB'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF56366', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF49879', 'properties': [{'key': 'EntryName', 'value': 'SMAD/FHA domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51075', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51076', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}], 'sequence': {'value': 'MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS', 'length': 467, 'molWeight': 52306, 'crc64': '95406DB5FC0AA4C9', 'md5': '53ADC62345013C9B257D9D822215079A'}, 'extraAttributes': {'countByCommentType': {'FUNCTION': 1, 'SUBUNIT': 1, 'INTERACTION': 27, 'SUBCELLULAR LOCATION': 1, 'ALTERNATIVE PRODUCTS': 2, 'TISSUE SPECIFICITY': 1, 'PTM': 3, 'DISEASE': 2, 'SIMILARITY': 1, 'WEB RESOURCE': 1}, 'countByFeatureType': {'Initiator methionine': 1, 'Chain': 1, 'Domain': 2, 'Region': 1, 'Motif': 1, 'Compositional bias': 2, 'Binding site': 4, 'Modified residue': 13, 'Alternative sequence': 1, 'Natural variant': 17, 'Mutagenesis': 13, 'Beta strand': 15, 'Helix': 8, 'Turn': 1}, 'uniParcId': 'UPI0000032EE7'}}]\\nExtracting GO terms\\nFetching UniProt entry for gene: SMAD3\\nUNIPROT RESULTS [{'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'P84022', 'secondaryAccessions': ['A8K4B6', 'B7Z4Z5', 'B7Z6M9', 'B7Z9Q2', 'F5H383', 'O09064', 'O09144', 'O14510', 'O35273', 'Q92940', 'Q93002', 'Q9GKR4'], 'uniProtkbId': 'SMAD3_HUMAN', 'entryAudit': {'firstPublicDate': '2004-07-05', 'lastAnnotationUpdateDate': '2025-06-18', 'lastSequenceUpdateDate': '2004-07-05', 'entryVersion': 215, 'sequenceVersion': 1}, 'annotationScore': 5.0, 'organism': {'scientificName': 'Homo sapiens', 'commonName': 'Human', 'taxonId': 9606, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Mothers against decapentaplegic homolog 3'}, 'shortNames': [{'value': 'MAD homolog 3'}, {'value': 'Mad3'}, {'value': 'Mothers against DPP homolog 3'}, {'value': 'hMAD-3'}]}, 'alternativeNames': [{'fullName': {'value': 'JV15-2'}}, {'fullName': {'value': 'SMAD family member 3'}, 'shortNames': [{'value': 'SMAD 3'}, {'value': 'Smad3'}, {'value': 'hSMAD3'}]}]}, 'genes': [{'geneName': {'value': 'SMAD3'}, 'synonyms': [{'value': 'MADH3'}]}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9732876'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': 'Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator'}], 'commentType': 'FUNCTION'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P84025'}, {'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11274402'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11278756'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11387212'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11427533'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12154125'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12370310'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '14525983'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15051726'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15350224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15561701'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15647271'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15897867'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16200078'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751102'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16777850'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17099224'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17292623'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18568018'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19049980'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20061380'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20129061'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '20935647'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24324267'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24613385'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24627487'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25105025'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '29899023'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9311995'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9665135'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9670020'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9732876'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9843571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9865696'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9892009'}], 'value': \\\"Monomer; in the absence of TGF-beta (PubMed:9670020). Homooligomer; in the presence of TGF-beta (PubMed:9670020). Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex (PubMed:11224571, PubMed:15350224, PubMed:15799969, PubMed:9670020). Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:9892009). Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta (PubMed:16751102). Found in a complex composed of SMAD3, RAN and XPO4; within the complex interacts directly with XPO4 (PubMed:16449645). Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta (PubMed:10995748, PubMed:9732876). Part of a ternary complex composed of SMAD3, ITCH/AIP4 and NEDD9/HEF1; within the complex NEDD9/HEF1 interacts (via N-terminus) with ITCH/AIP4; the complex mediates ubiquitination and proteasomal degradation of NEDD9/HEF1 (PubMed:15051726). Interacts with NEDD9; the interaction promotes NEDD9 ubiquitination and proteasomal degradation (PubMed:15051726). Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta (PubMed:10995748, PubMed:9732876). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (PubMed:24324267). Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling (PubMed:16751101). Interacts (via MH2 domain) with ZMIZ1 (via SP-RING-type domain); in the TGF-beta signaling pathway increases the activity of the SMAD3/SMAD4 transcriptional complex (PubMed:16777850). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD3 inhibitors (PubMed:9311995). Interacts (dephosphorylated form via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling (PubMed:19289081). Interacts (via MH2 domain) with LEMD3; the interaction represses SMAD3 transcriptional activity through preventing the formation of the heteromeric complex with SMAD4 and translocation to the nucleus (PubMed:15601644, PubMed:15647271). Interacts (via the linker region) with EP300 (C-terminal); the interaction promotes SMAD3 acetylation and is enhanced by TGF-beta phosphorylation in the C-terminal of SMAD3 (PubMed:15588252, PubMed:9843571). This interaction can be blocked by competitive binding of adenovirus oncoprotein E1A to the same C-terminal site on EP300, which then results in partially inhibited SMAD3/SMAD4 transcriptional activity (PubMed:15588252, PubMed:9843571). Interacts with TGFBR1 (PubMed:9311995). Interacts with TGFB1I1 (PubMed:15561701). Interacts with PRDM16 (PubMed:19049980). Interacts with SNW1 (PubMed:11278756). Interacts (via MH2 domain) with ZFYVE9 (PubMed:12154125, PubMed:9865696). Interacts with HDAC1 (PubMed:19049980). Interacts with TGIF2 (PubMed:11427533). Interacts with SKOR1 (PubMed:17292623). Interacts with SKOR2 (PubMed:16200078). Interacts with DACH1; the interaction inhibits the TGF-beta signaling (PubMed:14525983). Interacts with RBPMS (PubMed:17099224). Interacts (via MH2 domain) with MECOM (PubMed:15897867, PubMed:9665135). Interacts with WWTR1 (via its coiled-coil domain) (PubMed:18568018). Interacts with SKI; the interaction represses SMAD3 transcriptional activity (PubMed:19049980). Interacts with MEN1 (PubMed:11274402). Interacts with IL1F7 (PubMed:20935647). Interaction with CSNK1G2 (PubMed:18794808). Interacts with PDPK1 (via PH domain) (PubMed:17327236). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation (PubMed:11387212). Interacts with USP15 (PubMed:21947082). Interacts with PPP5C; the interaction decreases SMAD3 phosphorylation and protein levels (PubMed:22781750). Interacts with LDLRAD4 (via the SMAD interaction motif) (PubMed:24627487). Interacts with PMEPA1 (PubMed:20129061). Interacts with ZNF451 (PubMed:24324267). Interacts with ZFHX3 (PubMed:25105025). Interacts weakly with ZNF8 (PubMed:12370310). Interacts with STUB1, HSPA1A, HSPA1B, HSP90AA1 and HSP90AB1 (PubMed:24613385). Interacts with YAP1 (when phosphorylated at 'Ser-127') (By similarity). Interacts with MAGI2/ARIP1 (By similarity). Interacts (via MH2 domain) with CITED2 (via C-terminus) (By similarity). Interacts with HGS (By similarity). Interacts with WWP1 (By similarity). Interacts with TTRAP (By similarity). Interacts with FOXL2 (By similarity). Interacts with PML (By similarity). Interacts with NEDD4L; the interaction requires TGF-beta stimulation (By similarity). Interacts with ZC3H3 (By similarity). Interacts with TGIF. Interacts with CREBBP. Interacts with ATF2. Interacts with NEDD9; the interaction is inhibited by oxidation of NEDD9 (PubMed:29899023). Interacts with MTMR4; negatively regulates TGF-beta signaling through SMAD3 dephosphorylation and retention in endosomes (PubMed:20061380)\\\"}], 'commentType': 'SUBUNIT'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18055455'}], 'value': '(Microbial infection) Interacts with SARS-CoV nucleoprotein'}], 'commentType': 'SUBUNIT'}, {'commentType': 'INTERACTION', 'interactions': [{'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q06481-5', 'geneName': 'APLP2', 'intActId': 'EBI-25646567'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P05067', 'geneName': 'APP', 'intActId': 'EBI-77613'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H2G9', 'geneName': 'BLZF1', 'intActId': 'EBI-2548012'}, 'numberOfExperiments': 9, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9UQM7', 'geneName': 'CAMK2A', 'intActId': 'EBI-1383687'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P29466-3', 'geneName': 'CASP1', 'intActId': 'EBI-12248206'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'E9PSE9', 'geneName': 'CCDC198', 'intActId': 'EBI-11748295'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N5R6', 'geneName': 'CCDC33', 'intActId': 'EBI-740841'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H2X0', 'geneName': 'CHRD', 'intActId': 'EBI-947551'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N684', 'geneName': 'CPSF7', 'intActId': 'EBI-746909'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8N684-3', 'geneName': 'CPSF7', 'intActId': 'EBI-11523759'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O43186', 'geneName': 'CRX', 'intActId': 'EBI-748171'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q96PZ7', 'geneName': 'CSMD1', 'intActId': 'EBI-766158'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P48730-2', 'geneName': 'CSNK1D', 'intActId': 'EBI-9087876'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P98082', 'geneName': 'DAB2', 'intActId': 'EBI-1171238'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P17844', 'geneName': 'DDX5', 'intActId': 'EBI-351962'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZ29', 'geneName': 'DOCK9', 'intActId': 'EBI-2695893'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q86YD7', 'geneName': 'FAM90A1', 'intActId': 'EBI-6658203'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q01543', 'geneName': 'FLI1', 'intActId': 'EBI-2271018'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O75593', 'geneName': 'FOXH1', 'intActId': 'EBI-1759806'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O43524', 'geneName': 'FOXO3', 'intActId': 'EBI-1644164'}, 'numberOfExperiments': 5, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P10070', 'geneName': 'GLI2', 'intActId': 'EBI-10821567'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q16665', 'geneName': 'HIF1A', 'intActId': 'EBI-447269'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O15397', 'geneName': 'IPO8', 'intActId': 'EBI-358808'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8WXH2', 'geneName': 'JPH3', 'intActId': 'EBI-1055254'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P50222', 'geneName': 'MEOX2', 'intActId': 'EBI-748397'}, 'numberOfExperiments': 6, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9NYA4', 'geneName': 'MTMR4', 'intActId': 'EBI-1052346'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q99836', 'geneName': 'MYD88', 'intActId': 'EBI-447677'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P46934-3', 'geneName': 'NEDD4', 'intActId': 'EBI-11980721'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q16822', 'geneName': 'PCK2', 'intActId': 'EBI-2825219'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8IXK0', 'geneName': 'PHC2', 'intActId': 'EBI-713786'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8IXK0-5', 'geneName': 'PHC2', 'intActId': 'EBI-11527347'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P27986-2', 'geneName': 'PIK3R1', 'intActId': 'EBI-9090282'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BZL4', 'geneName': 'PPP1R12C', 'intActId': 'EBI-721802'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P17612', 'geneName': 'PRKACA', 'intActId': 'EBI-476586'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P20618', 'geneName': 'PSMB1', 'intActId': 'EBI-372273'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q96EP0', 'geneName': 'RNF31', 'intActId': 'EBI-948111'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P0C264', 'geneName': 'SBK3', 'intActId': 'EBI-17181801'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9BYW2', 'geneName': 'SETD2', 'intActId': 'EBI-945869'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P12755', 'geneName': 'SKI', 'intActId': 'EBI-347281'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q15796', 'geneName': 'SMAD2', 'intActId': 'EBI-1040141'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'P84022', 'geneName': 'SMAD3', 'intActId': 'EBI-347161'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13485', 'geneName': 'SMAD4', 'intActId': 'EBI-347263'}, 'numberOfExperiments': 37, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9HAU4', 'geneName': 'SMURF2', 'intActId': 'EBI-396727'}, 'numberOfExperiments': 8, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13573', 'geneName': 'SNW1', 'intActId': 'EBI-632715'}, 'numberOfExperiments': 5, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q13501', 'geneName': 'SQSTM1', 'intActId': 'EBI-307104'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q8WW24', 'geneName': 'TEKT4', 'intActId': 'EBI-750487'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q15583', 'geneName': 'TGIF1', 'intActId': 'EBI-714215'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q08117', 'geneName': 'TLE5', 'intActId': 'EBI-717810'}, 'numberOfExperiments': 4, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q08117-2', 'geneName': 'TLE5', 'intActId': 'EBI-11741437'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9Y3Q8', 'geneName': 'TSC22D4', 'intActId': 'EBI-739485'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q93009', 'geneName': 'USP7', 'intActId': 'EBI-302474'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q9H0M0', 'geneName': 'WWP1', 'intActId': 'EBI-742157'}, 'numberOfExperiments': 9, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O00308', 'geneName': 'WWP2', 'intActId': 'EBI-743923'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q5D1E8', 'geneName': 'ZC3H12A', 'intActId': 'EBI-747793'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O95405', 'geneName': 'ZFYVE9', 'intActId': 'EBI-296817'}, 'numberOfExperiments': 7, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q6NX45', 'geneName': 'ZNF774', 'intActId': 'EBI-10251462'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'Q64729', 'geneName': 'Tgfbr1', 'intActId': 'EBI-2899393'}, 'numberOfExperiments': 6, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P84022', 'intActId': 'EBI-347161'}, 'interactantTwo': {'uniProtKBAccession': 'O92972', 'chainId': 'PRO_0000278742', 'intActId': 'EBI-9213553'}, 'numberOfExperiments': 6, 'organismDiffer': True}]}, {'commentType': 'SUBCELLULAR LOCATION', 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}], 'value': 'Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)'}]}, 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}], 'value': 'Cytoplasm', 'id': 'SL-0086'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15601644'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15799969'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16751101'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19289081'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21145499'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22781750'}], 'value': 'Nucleus', 'id': 'SL-0191'}}]}, {'commentType': 'ALTERNATIVE PRODUCTS', 'events': ['Alternative splicing'], 'isoforms': [{'name': {'value': '1'}, 'isoformIds': ['P84022-1'], 'isoformSequenceStatus': 'Displayed'}, {'name': {'value': '2'}, 'isoformIds': ['P84022-2'], 'sequenceIds': ['VSP_042900'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '3'}, 'isoformIds': ['P84022-3'], 'sequenceIds': ['VSP_043793'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '4'}, 'isoformIds': ['P84022-4'], 'sequenceIds': ['VSP_045348'], 'isoformSequenceStatus': 'Described'}]}, {'texts': [{'value': 'The MH1 domain is required for DNA binding. Also binds zinc ions which are necessary for the DNA binding'}], 'commentType': 'DOMAIN'}, {'texts': [{'value': 'The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import'}], 'commentType': 'DOMAIN'}, {'texts': [{'value': 'The linker region is required for the TGFbeta-mediated transcriptional activity and acts synergistically with the MH2 domain'}], 'commentType': 'DOMAIN'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15588252'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17327236'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8774881'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9843571'}], 'value': 'Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF and TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Phosphorylated by PDPK1'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'value': 'Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '25133494'}], 'value': 'Poly-ADP-ribosylated by PARP1 and PARP2. ADP-ribosylation negatively regulates SMAD3 transcriptional responses during the course of TGF-beta signaling'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '24613385'}], 'value': \\\"Ubiquitinated. Monoubiquitinated, leading to prevent DNA-binding (PubMed:21947082). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD3 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD3 and regulating its turnover (By similarity). Undergoes STUB1-mediated ubiquitination and degradation (PubMed:24613385)\\\"}], 'commentType': 'PTM'}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Colorectal cancer', 'diseaseAccession': 'DI-01359', 'acronym': 'CRC', 'description': 'A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.', 'diseaseCrossReference': {'database': 'MIM', 'id': '114500'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}]}, 'note': {'texts': [{'value': 'The disease may be caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Loeys-Dietz syndrome 3', 'diseaseAccession': 'DI-03064', 'acronym': 'LDS3', 'description': 'An aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by the triad of arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Patients with LDS3 also manifest early-onset osteoarthritis. They lack craniosynostosis and intellectual disability.', 'diseaseCrossReference': {'database': 'MIM', 'id': '613795'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}]}, 'note': {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'value': 'The disease is caused by variants affecting the gene represented in this entry. SMAD3 mutations have been reported to be also associated with thoracic aortic aneurysms and dissection (TAAD) (PubMed:21778426). This phenotype is distinguised from LDS3 by having aneurysms restricted to thoracic aorta. As individuals carrying these mutations also exhibit aneurysms of other arteries, including abdominal aorta, iliac, and/or intracranial arteries (PubMed:21778426), they have been classified as LDS3 by the OMIM resource'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Belongs to the dwarfin/SMAD family'}], 'commentType': 'SIMILARITY'}], 'features': [{'type': 'Initiator methionine', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 1, 'modifier': 'EXACT'}}, 'description': 'Removed', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Chain', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Mothers against decapentaplegic homolog 3', 'featureId': 'PRO_0000090856'}, {'type': 'Domain', 'location': {'start': {'value': 10, 'modifier': 'EXACT'}, 'end': {'value': 136, 'modifier': 'EXACT'}}, 'description': 'MH1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00438'}]}, {'type': 'Domain', 'location': {'start': {'value': 232, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'MH2', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Region', 'location': {'start': {'value': 137, 'modifier': 'EXACT'}, 'end': {'value': 231, 'modifier': 'EXACT'}}, 'description': 'Linker'}, {'type': 'Region', 'location': {'start': {'value': 165, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Region', 'location': {'start': {'value': 271, 'modifier': 'EXACT'}, 'end': {'value': 324, 'modifier': 'EXACT'}}, 'description': 'Sufficient for interaction with XPO4', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}]}, {'type': 'Compositional bias', 'location': {'start': {'value': 165, 'modifier': 'EXACT'}, 'end': {'value': 177, 'modifier': 'EXACT'}}, 'description': 'Polar residues', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Binding site', 'location': {'start': {'value': 64, 'modifier': 'EXACT'}, 'end': {'value': 64, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 109, 'modifier': 'EXACT'}, 'end': {'value': 109, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 121, 'modifier': 'EXACT'}, 'end': {'value': 121, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Binding site', 'location': {'start': {'value': 126, 'modifier': 'EXACT'}, 'end': {'value': 126, 'modifier': 'EXACT'}}, 'description': '', 'featureCrossReferences': [{'database': 'ChEBI', 'id': 'CHEBI:29105'}], 'ligand': {'name': 'Zn(2+)', 'id': 'ChEBI:CHEBI:29105'}}, {'type': 'Site', 'location': {'start': {'value': 40, 'modifier': 'EXACT'}, 'end': {'value': 40, 'modifier': 'EXACT'}}, 'description': 'Required for trimerization'}, {'type': 'Site', 'location': {'start': {'value': 41, 'modifier': 'EXACT'}, 'end': {'value': 41, 'modifier': 'EXACT'}}, 'description': 'Required for interaction with DNA and JUN and for functional cooperation with JUN'}, {'type': 'Modified residue', 'location': {'start': {'value': 2, 'modifier': 'EXACT'}, 'end': {'value': 2, 'modifier': 'EXACT'}}, 'description': 'N-acetylserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '19413330'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '22814378'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by CDK2 and CDK4', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine; by CDK2, CDK4 and MAPK', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 204, 'modifier': 'EXACT'}, 'end': {'value': 204, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by GSK3 and MAPK', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 208, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by MAPK', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 213, 'modifier': 'EXACT'}, 'end': {'value': 213, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CDK2 and CDK4', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 416, 'modifier': 'EXACT'}, 'end': {'value': 416, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '18669648'}, {'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '23186163'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by CK1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 422, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 423, 'modifier': 'EXACT'}, 'end': {'value': 423, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 425, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine; by TGFBR1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'Q8BUN5'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00439'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 33, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '21947082'}]}, {'type': 'Cross-link', 'location': {'start': {'value': 81, 'modifier': 'EXACT'}, 'end': {'value': 81, 'modifier': 'EXACT'}}, 'description': 'Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '21947082'}]}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 195, 'modifier': 'EXACT'}}, 'description': 'in isoform 4', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_045348', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 105, 'modifier': 'EXACT'}}, 'description': 'in isoform 3', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_043793', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 68, 'modifier': 'EXACT'}}, 'description': 'in isoform 2', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_042900', 'alternativeSequence': {'originalSequence': 'MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIP', 'alternativeSequences': ['MSCLHPRQTWKGAALVHRKAWWMG']}}, {'type': 'Natural variant', 'location': {'start': {'value': 112, 'modifier': 'EXACT'}, 'end': {'value': 112, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906854', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906854'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067051', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 170, 'modifier': 'EXACT'}, 'end': {'value': 170, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs35874463', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs35874463'}], 'featureId': 'VAR_052021', 'alternativeSequence': {'originalSequence': 'I', 'alternativeSequences': ['V']}}, {'type': 'Natural variant', 'location': {'start': {'value': 239, 'modifier': 'EXACT'}, 'end': {'value': 239, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906853', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906853'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067047', 'alternativeSequence': {'originalSequence': 'E', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 261, 'modifier': 'EXACT'}, 'end': {'value': 261, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906851', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906851'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}], 'featureId': 'VAR_065578', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 279, 'modifier': 'EXACT'}, 'end': {'value': 279, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906852', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906852'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21778426'}], 'featureId': 'VAR_067048', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['K']}}, {'type': 'Natural variant', 'location': {'start': {'value': 287, 'modifier': 'EXACT'}, 'end': {'value': 287, 'modifier': 'EXACT'}}, 'description': 'in LDS3; dbSNP:rs387906850', 'featureCrossReferences': [{'database': 'dbSNP', 'id': 'rs387906850'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21217753'}], 'featureId': 'VAR_065579', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 393, 'modifier': 'EXACT'}, 'end': {'value': 393, 'modifier': 'EXACT'}}, 'description': 'in a colorectal cancer sample; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}], 'featureId': 'VAR_036474', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 8, 'modifier': 'EXACT'}, 'end': {'value': 8, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation, increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-179 and A-213.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['V']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 33, 'modifier': 'EXACT'}, 'end': {'value': 33, 'modifier': 'EXACT'}}, 'description': 'Slightly decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 40, 'modifier': 'EXACT'}, 'end': {'value': 40, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-41; A-43 and A-44.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 41, 'modifier': 'EXACT'}, 'end': {'value': 41, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced interaction with DNA and JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-44 and A-43.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 43, 'modifier': 'EXACT'}, 'end': {'value': 43, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with DNA and JUN; when associated with A-40; A-41 and A-44.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 44, 'modifier': 'EXACT'}, 'end': {'value': 44, 'modifier': 'EXACT'}}, 'description': 'Little effect on interaction with DNA or JUN. Abolishes interaction with JUN; when associated with A-40; A-41 and A-43.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 53, 'modifier': 'EXACT'}, 'end': {'value': 53, 'modifier': 'EXACT'}}, 'description': 'Slightly decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 74, 'modifier': 'EXACT'}, 'end': {'value': 74, 'modifier': 'EXACT'}}, 'description': 'Reduced interaction with JUN. Loss of transcriptional activity and cooperation with JUN.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10995748'}], 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 81, 'modifier': 'EXACT'}, 'end': {'value': 81, 'modifier': 'EXACT'}}, 'description': 'Decreased monoubiquitination.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21947082'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 179, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation, increased transcriptional and increased antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and A-213.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['V']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 204, 'modifier': 'EXACT'}, 'end': {'value': 204, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. Further increased transcriptional activity; when associated with S-208.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 208, 'modifier': 'EXACT'}, 'end': {'value': 208, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. Further increased transcriptional activity; when associated with S-208.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16156666'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19218245'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 213, 'modifier': 'EXACT'}, 'end': {'value': 213, 'modifier': 'EXACT'}}, 'description': 'Reduced phosphorylation. Increased transcriptional and antiproliferative activities. Further increase in transcriptional and antiproliferative activities; when associated with V-8 and V-179.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15241418'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 333, 'modifier': 'EXACT'}, 'end': {'value': 333, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-341; R-378 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 341, 'modifier': 'EXACT'}, 'end': {'value': 341, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-378 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'Increased transcriptional activity. No further increase in transcriptional activity with EP300.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['Q']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 378, 'modifier': 'EXACT'}}, 'description': 'Greatly reduced acetylation and 85% reduction in transcriptional activity. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-409.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 409, 'modifier': 'EXACT'}, 'end': {'value': 409, 'modifier': 'EXACT'}}, 'description': 'No effect on acetylation. Completely abolishes acetylation and 97% reduction in transcriptional activity; when associated with R-333; R-341 and R-378.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['R']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Increased constitutive activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['A']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 418, 'modifier': 'EXACT'}, 'end': {'value': 418, 'modifier': 'EXACT'}}, 'description': 'Decreased activity.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18794808'}], 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['D']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Does not abolish protein nuclear export. Abolishes almost completely acetylation.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'SSVS', 'alternativeSequences': ['AAVA']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Forms heterotrimers.', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11224571'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16449645'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16862174'}], 'alternativeSequence': {'originalSequence': 'SSVS', 'alternativeSequences': ['EEVE']}}, {'type': 'Mutagenesis', 'location': {'start': {'value': 422, 'modifier': 'EXACT'}, 'end': {'value': 425, 'modifier': 'EXACT'}}, 'description': 'Diminishes 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'PANTHER', 'id': 'PTHR13703', 'properties': [{'key': 'EntryName', 'value': 'SMAD'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03165', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF03166', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00523', 'properties': [{'key': 'EntryName', 'value': 'DWA'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SMART', 'id': 'SM00524', 'properties': [{'key': 'EntryName', 'value': 'DWB'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF56366', 'properties': [{'key': 'EntryName', 'value': 'SMAD MH1 domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF49879', 'properties': [{'key': 'EntryName', 'value': 'SMAD/FHA domain'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51075', 'properties': [{'key': 'EntryName', 'value': 'MH1'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS51076', 'properties': [{'key': 'EntryName', 'value': 'MH2'}, {'key': 'MatchStatus', 'value': '1'}]}], 'sequence': {'value': 'MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS', 'length': 425, 'molWeight': 48081, 'crc64': '46DF5E8B371321AC', 'md5': 'E53D209C5415702B891BABFE30ECE27A'}, 'extraAttributes': {'countByCommentType': {'FUNCTION': 1, 'SUBUNIT': 2, 'INTERACTION': 58, 'SUBCELLULAR LOCATION': 1, 'ALTERNATIVE PRODUCTS': 4, 'DOMAIN': 3, 'PTM': 4, 'DISEASE': 2, 'SIMILARITY': 1}, 'countByFeatureType': {'Initiator methionine': 1, 'Chain': 1, 'Domain': 2, 'Region': 3, 'Compositional bias': 1, 'Binding site': 4, 'Site': 2, 'Modified residue': 12, 'Cross-link': 2, 'Alternative sequence': 3, 'Natural variant': 7, 'Mutagenesis': 23, 'Sequence conflict': 2, 'Helix': 16, 'Beta strand': 22}, 'uniParcId': 'UPI0000023A91'}}]\\nExtracting GO terms\\n[conditioned_claude_node_with_citations] building documents...\\n[conditioned_claude_node] USER QUESTION:\\nCompare druggability of SMAD2 and SMAD3. Be thorough, and discuss different ways to target, existing drugs and possible issues\\n---\\nMessage(id='msg_01KEjpsA1C66fXQqUJce7MUd', content=[TextBlock(citations=None, text='# Druggability Comparison: SMAD2 vs SMAD3\\\\n\\\\n## Direct Druggability Evidence\\\\n\\\\n### SMAD2\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='No ChEMBL druggability data found for SMAD2', type='text'), TextBlock(citations=None, text=', indicating a lack of validated small molecule inhibitors or modulators in the ChEMBL database.\\\\n\\\\n### SMAD3\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n', document_index=1, document_title='GENE: SMAD3', end_char_index=12606, start_char_index=10810, type='char_location')], text='SMAD3 has documented bioactivity evidence with 25 compounds showing IC50 values ranging from 38.00 nM to 9894.00 nM, with the most potent compounds being CHEMBL601757 (IC50=38.00 nM, pChEMBL=7.42) and CHEMBL1334062 (IC50=39.00 nM, pChEMBL=7.41)', type='text'), TextBlock(citations=None, text='. ', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n', document_index=1, document_title='GENE: SMAD3', end_char_index=12375, start_char_index=10810, type='char_location')], text='Notable compounds include CHEMBL6246 (ELLAGIC ACID) with IC50=142.00 nM (pChEMBL=6.85)', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**Key Finding:** SMAD3 demonstrates significantly better druggability with validated small molecule inhibitors, while SMAD2 lacks such evidence.\\\\n\\\\n---\\\\n\\\\n## Structural Features Relevant to Druggability\\\\n\\\\n### Cysteine Residues (Potential Covalent Drug Targets)\\\\n\\\\n**SMAD2:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='Has 14 detected cysteines, with 2 ligandable cysteines (Q15796_C74, Q15796_C81), 3 binding-site cysteines, and 2 near binding-site cysteines', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**SMAD3:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. ', document_index=1, document_title='GENE: SMAD3', end_char_index=9580, start_char_index=0, type='char_location')], text='Has only 5 detected cysteines, with 0 ligandable cysteines, though 3 are binding-site cysteines', type='text'), TextBlock(citations=None, text=\\\".\\\\n\\\\n**Implication:** SMAD2's ligandable cysteines (C74 and C81) represent potential sites for covalent inhibitor development, offering a druggability advantage over SMAD3 for this approach.\\\\n\\\\n### Protein Disorder and Binding Regions\\\\n\\\\n**SMAD2:**\\\\n\\\", type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='Shows 22.7% disordered regions with 3 disordered regions (longest=68 residues) and 14.1% high MoRF propensity (longest segment=66 residues)', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**SMAD3:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. ', document_index=1, document_title='GENE: SMAD3', end_char_index=9580, start_char_index=0, type='char_location')], text='Shows 22.6% disordered regions with 4 disordered regions (longest=67 residues) and 13.9% high MoRF propensity (longest segment=59 residues)', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**Implication:** Both proteins have similar disorder profiles, suggesting comparable challenges for traditional small molecule binding but potential opportunities for targeting protein-protein interactions through MoRF regions.\\\\n\\\\n### Druggable Pockets\\\\n\\\\n**SMAD2:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='FPocket scores range from 0.0 to 0.713 (avg=0.037)', type='text'), TextBlock(citations=None, text=', with the maximum suggesting at least one potentially druggable pocket.\\\\n\\\\n**SMAD3:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. ', document_index=1, document_title='GENE: SMAD3', end_char_index=9580, start_char_index=0, type='char_location')], text='FPocket scores range from 0.0 to 0.136 (avg=0.010)', type='text'), TextBlock(citations=None, text=', indicating lower overall pocket druggability.\\\\n\\\\n---\\\\n\\\\n## Targeting Strategies\\\\n\\\\n### 1. Direct Small Molecule Inhibition\\\\n\\\\n**Current Status:**\\\\n- **SMAD3:** Validated approach with nanomolar inhibitors available\\\\n- **SMAD2:** No validated small molecules reported\\\\n\\\\n**Challenges:**\\\\n- Both proteins function as transcription factors, traditionally considered \\\"undruggable\\\"\\\\n- High structural similarity between SMAD2 and SMAD3 may complicate selectivity\\\\n\\\\n### 2. Protein-Protein Interaction (PPI) Disruption\\\\n\\\\nBoth proteins form critical complexes:\\\\n\\\\n**SMAD2 interactions:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='Forms heteromeric SMAD protein complexes and interacts with SMAD3, SMAD4, and numerous co-factors including CREBBP, EP300, SKI, SKIL', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**SMAD3 interactions:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. ', document_index=1, document_title='GENE: SMAD3', end_char_index=9580, start_char_index=0, type='char_location')], text='Interacts with SMAD2, SMAD4, and similar co-factors, with documented co-crystal structures with SMAD3, SMAD4, and ZFYVE9', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**Targeting opportunities:**\\\\n- SMAD2/3-SMAD4 heterotrimer formation\\\\n- Interactions with transcriptional co-activators (CREBBP, EP300)\\\\n- Interactions with inhibitory proteins (SKI, SKIL)\\\\n\\\\n### 3. Covalent Inhibitor Development\\\\n\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text=\\\"SMAD2's two ligandable cysteines (C74, C81) near binding sites\\\", type='text'), TextBlock(citations=None, text=' represent attractive targets for covalent inhibitors, potentially offering:\\\\n- Improved selectivity over SMAD3\\\\n- Enhanced potency through irreversible binding\\\\n- Longer duration of action\\\\n\\\\n### 4. Targeting Post-Translational Modifications\\\\n\\\\nBoth proteins undergo extensive regulation:\\\\n\\\\n**SMAD2:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='Participates in pathways including \\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\" and \\\"Post-translational protein modification\\\"', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**SMAD3:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. ', document_index=1, document_title='GENE: SMAD3', end_char_index=9580, start_char_index=0, type='char_location')], text='Shows biochemical activity with multiple kinases (CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1) and deubiquitinases (OTUB1, USP15, USP7)', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**Targeting strategies:**\\\\n- Inhibit activating kinases (TGFBR1)\\\\n- Inhibit CDKs that phosphorylate linker regions\\\\n- Target E3 ubiquitin ligases (SMURF1, SMURF2, WWP2)\\\\n- Inhibit deubiquitinases to promote degradation\\\\n\\\\n### 5. Targeted Protein Degradation (PROTACs/Molecular Glues)\\\\n\\\\n**Advantages:**\\\\n- Circumvents need for traditional binding pockets\\\\n- Can achieve selectivity through E3 ligase recruitment\\\\n- Particularly attractive for SMAD2 given lack of direct inhibitors\\\\n\\\\n**Feasibility:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='SMAD2 interacts with multiple E3 ligases including SMURF2, WWP2, ITCH, NEDD4, NEDD4L', type='text'), TextBlock(citations=None, text=', and ', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. ', document_index=1, document_title='GENE: SMAD3', end_char_index=9580, start_char_index=0, type='char_location')], text='SMAD3 shows similar interactions with NEDD4, NEDD4L, SMURF1, SMURF2, WWP2', type='text'), TextBlock(citations=None, text=', providing natural degradation pathways to exploit.\\\\n\\\\n---\\\\n\\\\n## Existing Therapeutic Approaches\\\\n\\\\n### Indirect Targeting via TGF-β Pathway\\\\n\\\\nBoth proteins are downstream of TGF-β receptor signaling:\\\\n\\\\n**SMAD2:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='Participates in \\\"TGF-beta receptor signaling activates SMADs\\\" and \\\"Signaling by TGF-beta Receptor Complex\\\"', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**SMAD3:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. ', document_index=1, document_title='GENE: SMAD3', end_char_index=9580, start_char_index=0, type='char_location')], text='Similarly involved in TGF-β receptor signaling pathways', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**Clinical relevance:**\\\\n- TGF-β receptor inhibitors (e.g., galunisertib) indirectly block SMAD2/3 activation\\\\n- This approach affects both proteins simultaneously, limiting selectivity\\\\n\\\\n---\\\\n\\\\n## Disease Context and Therapeutic Potential\\\\n\\\\n### SMAD2 Disease Associations\\\\n\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text=\\\"*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. \\\", document_index=0, document_title='GENE: SMAD2', end_char_index=39230, start_char_index=19631, type='char_location')], text='SMAD2 is associated with Loeys-Dietz syndrome 6, congenital heart defects, multiple types, 8, with or without heterotaxy, and numerous cancers including colorectal adenocarcinoma, glioblastoma, and breast cancer', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n### SMAD3 Disease Associations\\\\n\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3. ', document_index=1, document_title='GENE: SMAD3', end_char_index=31176, start_char_index=30923, type='char_location')], text='SMAD3 is associated with Colorectal cancer and Loeys-Dietz syndrome 3', type='text'), TextBlock(citations=None, text=', plus ', type='text'), TextBlock(citations=[CitationCharLocation(cited_text=\\\"*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. \\\", document_index=1, document_title='GENE: SMAD3', end_char_index=64988, start_char_index=31176, type='char_location')], text='extensive associations with cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**Therapeutic implications:**\\\\n- **Cancer:** Both are tumor suppressors; inhibition may be contraindicated\\\\n- **Fibrosis:** SMAD3 inhibition shows promise (existing compounds available)\\\\n- **Cardiovascular disease:** Context-dependent; may require selective modulation\\\\n\\\\n---\\\\n\\\\n## Genetic Constraint and Safety Considerations\\\\n\\\\n### Loss-of-Function Tolerance\\\\n\\\\n**SMAD2:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text=\\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0 *HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. \\\", document_index=0, document_title='GENE: SMAD2', end_char_index=43588, start_char_index=42754, type='char_location')], text='Genetic constraint score for lof variants: 1.0 (mapped to LOEUF rank, lower = less tolerant)', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**SMAD3:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text=\\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555 *GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\\\", document_index=1, document_title='GENE: SMAD3', end_char_index=69820, start_char_index=68478, type='char_location')], text='Genetic constraint score for lof variants: 0.9999799728393555', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**Interpretation:** Both proteins show high constraint scores (~1.0), indicating that loss-of-function variants are relatively well-tolerated in the population, suggesting potential safety for therapeutic inhibition.\\\\n\\\\n### Essentiality\\\\n\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='*OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). ', document_index=0, document_title='GENE: SMAD2', end_char_index=42754, start_char_index=42599, type='char_location')], text='SMAD2 is not a core essential gene', type='text'), TextBlock(citations=None, text=', and ', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='*OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). ', document_index=1, document_title='GENE: SMAD3', end_char_index=68478, start_char_index=68323, type='char_location')], text='SMAD3 is not a core essential gene', type='text'), TextBlock(citations=None, text=', indicating that complete inhibition may be tolerated, though context-dependent effects are likely.\\\\n\\\\n---\\\\n\\\\n## Tissue-Specific Expression Considerations\\\\n\\\\n### SMAD2\\\\n\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='*OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'frontal lobe\\\\': -1, \\\\'endothelial cell of umbilical vein (resting)\\\\': 2, \\\\'zone of skin\\\\': 0, \\\\'regulatory T cell\\\\': 1, \\\\'pancreas\\\\': -1, \\\\'suprapubic skin\\\\': -1, \\\\'temporal lobe\\\\': -1, \\\\'parathyroid gland\\\\': -1, \\\\'spleen\\\\': -1, \\\\'Brodmann (1909) area 9\\\\': -1, \\\\'breast\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': -1, \\\\'alternatively activated macrophage\\\\': 2, \\\\'segmented neutrophil of bone marrow\\\\': 4, \\\\'placenta\\\\': -1, \\\\'mature eosinophil\\\\': 1, \\\\'granulocyte monocyte progenitor cell\\\\': 0, \\\\'gall bladder\\\\': -1, \\\\'esophagus muscularis mucosa\\\\': -1, \\\\'seminal vesicle\\\\': -1, \\\\'endocervix\\\\': -1, \\\\'lower leg skin\\\\': -1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 2, \\\\'CD8-positive, alpha-beta T cell\\\\': 3, \\\\'cerebral cortex\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': 4, \\\\'hippocampus proper\\\\': -1, \\\\'uterus\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': 3, \\\\'tonsil\\\\': -1, \\\\'esophagus\\\\': 0, \\\\'transverse colon\\\\': -1, \\\\'pituitary gland\\\\': -1, \\\\'coronary artery\\\\': -1, \\\\'memory B cell\\\\': 0, \\\\'sigmoid colon\\\\': -1, \\\\'cerebellum\\\\': -1, \\\\'erythroblast\\\\': 2, \\\\'prefrontal cortex\\\\': -1, \\\\'nucleus accumbens\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'vermiform appendix\\\\': -1, \\\\'greater omentum\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': 1, \\\\'leukocyte\\\\': 2, \\\\'adrenal gland\\\\': -1, \\\\'atrium auricular region\\\\': -1, \\\\'thyroid gland\\\\': 0, \\\\'tibial artery\\\\': -1, \\\\'common lymphoid progenitor\\\\': 3, \\\\'urinary bladder\\\\': -1, \\\\'duodenum\\\\': -1, \\\\'heart muscle\\\\': -1, \\\\'small intestine\\\\': -1, \\\\'neutrophilic metamyelocyte\\\\': 3, \\\\'minor salivary gland\\\\': -1, \\\\'rectum\\\\': 0, \\\\'ovary\\\\': -1, \\\\'substantia nigra\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': -1, \\\\'class switched memory B cell\\\\': 1, \\\\'fallopian tube\\\\': -1, \\\\'esophagus mucosa\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 0, \\\\'bronchus\\\\': -1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": -1, \\\\'kidney\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'macrophage\\\\': 1, \\\\'aorta\\\\': -1, \\\\'skeletal muscle tissue\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': 4, \\\\'caudate-putamen\\\\': -1, \\\\'liver\\\\': -1, \\\\'cytotoxic CD56-dim natural killer cell\\\\': 2, \\\\'mature neutrophil\\\\': 2, \\\\'hypothalamus\\\\': -1, \\\\'transformed skin fibroblast\\\\': -1, \\\\'bone marrow\\\\': -1, \\\\'inflammatory macrophage\\\\': 0, \\\\'cortex of kidney\\\\': -1, \\\\'lung\\\\': -1, \\\\'epididymis\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'saliva-secreting gland\\\\': -1, \\\\'nasopharynx\\\\': -1, \\\\'colon\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'stomach\\\\': -1, \\\\'testis\\\\': -1, \\\\'smooth muscle tissue\\\\': 0, \\\\'putamen\\\\': -1, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 5, \\\\'C1 segment of cervical spinal cord\\\\': 0, \\\\'blood\\\\': -1, \\\\'hematopoietic stem cell\\\\': 1, \\\\'caudate nucleus\\\\': -1, \\\\'amygdala\\\\': -1, \\\\'brain\\\\': 0, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'ectocervix\\\\': -1, \\\\'prostate gland\\\\': -1, \\\\'conventional dendritic cell\\\\': 4, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'heart left ventricle\\\\': -1, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 0, \\\\'vagina\\\\': -1, \\\\'esophagogastric junction\\\\': -1, \\\\'lymph node\\\\': -1, \\\\'endometrium\\\\': -1, \\\\'heart\\\\': -1, \\\\'oral mucosa\\\\': -1, \\\\'CD8-positive, alpha-beta thymocyte\\\\': 4, \\\\'common myeloid progenitor\\\\': 0, \\\\'tibial nerve\\\\': -1, \\\\'plasma cell\\\\': -1}. ', document_index=0, document_title='GENE: SMAD2', end_char_index=42599, start_char_index=39230, type='char_location')], text='Shows high tissue-specific expression (z-score ≥2) in: segmented neutrophil of bone marrow (z=4), CD34-negative megakaryocyte cell (z=4), CD8-positive alpha-beta T cell (z=3), CD4-positive alpha-beta T cell (z=3), common lymphoid progenitor (z=3), conventional dendritic cell (z=4), CD4-positive alpha-beta thymocyte (z=5), CD8-positive alpha-beta thymocyte (z=4)', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n### SMAD3\\\\n\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='*OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'breast\\\\': 0, \\\\'atrium auricular region\\\\': 1, \\\\'liver\\\\': 0, \\\\'skeletal muscle tissue\\\\': 1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\\'esophagus mucosa\\\\': 1, \\\\'macrophage\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'segmented neutrophil of bone marrow\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': -1, \\\\'class switched memory B cell\\\\': 0, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 3, \\\\'Brodmann (1909) area 9\\\\': 0, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 1, \\\\'zone of skin\\\\': 1, \\\\'leukocyte\\\\': 0, \\\\'nasopharynx\\\\': -1, \\\\'tonsil\\\\': 0, \\\\'frontal lobe\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'putamen\\\\': 0, \\\\'hematopoietic stem cell\\\\': -1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'testis\\\\': -1, \\\\'bronchus\\\\': -1, \\\\'sigmoid colon\\\\': 0, \\\\'fallopian tube\\\\': 0, \\\\'plasma cell\\\\': -1, \\\\'aorta\\\\': 0, \\\\'adrenal gland\\\\': -1, \\\\'kidney\\\\': 0, \\\\'endometrium\\\\': 0, \\\\'smooth muscle tissue\\\\': 0, \\\\'tibial artery\\\\': 0, \\\\'prefrontal cortex\\\\': 0, \\\\'CD8-positive, alpha-beta T cell\\\\': -1, \\\\'vermiform appendix\\\\': 0, \\\\'lymph node\\\\': 0, \\\\'duodenum\\\\': 0, \\\\'mature eosinophil\\\\': 0, \\\\'prostate gland\\\\': 1, \\\\'C1 segment of cervical spinal cord\\\\': -1, \\\\'lung\\\\': 0, \\\\'inflammatory macrophage\\\\': -1, \\\\'rectum\\\\': 0, \\\\'suprapubic skin\\\\': 0, \\\\'brain\\\\': -1, \\\\'coronary artery\\\\': 0, \\\\'parathyroid gland\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': 0, \\\\'esophagus muscularis mucosa\\\\': 0, \\\\'esophagus\\\\': 1, \\\\'transformed skin fibroblast\\\\': 1, \\\\'heart muscle\\\\': -1, \\\\'pancreas\\\\': 0, \\\\'uterus\\\\': 0, \\\\'placenta\\\\': 0, \\\\'seminal vesicle\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'endothelial cell of umbilical vein (resting)\\\\': 0, \\\\'minor salivary gland\\\\': 0, \\\\'endocervix\\\\': 1, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'CD8-positive, alpha-beta thymocyte\\\\': -1, \\\\'granulocyte monocyte progenitor cell\\\\': -1, \\\\'caudate nucleus\\\\': 0, \\\\'amygdala\\\\': 0, \\\\'temporal lobe\\\\': 0, \\\\'substantia nigra\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'common lymphoid progenitor\\\\': 0, \\\\'cerebral cortex\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 0, \\\\'blood\\\\': -1, \\\\'nucleus accumbens\\\\': 0, \\\\'stomach\\\\': 0, \\\\'oral mucosa\\\\': -1, \\\\'mature neutrophil\\\\': 0, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'bone marrow\\\\': -1, \\\\'gall bladder\\\\': 1, \\\\'colon\\\\': 0, \\\\'cytotoxic CD56-dim natural killer cell\\\\': -1, \\\\'pituitary gland\\\\': 0, \\\\'transverse colon\\\\': 0, \\\\'heart left ventricle\\\\': 0, \\\\'erythroblast\\\\': -1, \\\\'vagina\\\\': 1, \\\\'ovary\\\\': 1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': 1, \\\\'cerebellum\\\\': -1, \\\\'hypothalamus\\\\': -1, \\\\'common myeloid progenitor\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': -1, \\\\'alternatively activated macrophage\\\\': -1, \\\\'thyroid gland\\\\': 1, \\\\'lower leg skin\\\\': 0, \\\\'epididymis\\\\': -1, \\\\'spleen\\\\': 0, \\\\'esophagogastric junction\\\\': 0, \\\\'greater omentum\\\\': 1, \\\\'memory B cell\\\\': 0, \\\\'hippocampus proper\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': -1, \\\\'small intestine\\\\': 1, \\\\'conventional dendritic cell\\\\': -1, \\\\'cortex of kidney\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": 0, \\\\'heart\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': -1, \\\\'caudate-putamen\\\\': -1, \\\\'urinary bladder\\\\': 1, \\\\'ectocervix\\\\': 1, \\\\'regulatory T cell\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 1, \\\\'saliva-secreting gland\\\\': 0, \\\\'neutrophilic metamyelocyte\\\\': -1, \\\\'tibial nerve\\\\': 0}. ', document_index=1, document_title='GENE: SMAD3', end_char_index=68323, start_char_index=64988, type='char_location')], text='Shows high tissue-specific expression in: CD14-positive, CD16-negative classical monocyte (z=3)', type='text'), TextBlock(citations=None, text=\\\", with generally lower tissue specificity than SMAD2.\\\\n\\\\n**Implication:** SMAD2's higher expression in immune cells may complicate systemic inhibition due to immunological effects, while SMAD3's broader expression pattern may present different toxicity concerns.\\\\n\\\\n---\\\\n\\\\n## Challenges and Considerations\\\\n\\\\n### 1. Selectivity Between SMAD2 and SMAD3\\\\n\\\\n- High structural similarity (both R-SMADs)\\\\n- Overlapping functions in TGF-β signaling\\\\n- \\\", type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='Both form SMAD2/SMAD3:SMAD4 heterotrimers', type='text'), TextBlock(citations=None, text='\\\\n- Selective inhibition may require exploiting unique interaction surfaces or post-translational modification sites\\\\n\\\\n### 2. Context-Dependent Functions\\\\n\\\\n**Tumor suppressor vs. oncogenic roles:**\\\\n- In early cancer stages: tumor suppressive (inhibition contraindicated)\\\\n- In advanced cancer/metastasis: pro-metastatic (inhibition beneficial)\\\\n- Requires careful patient stratification\\\\n\\\\n### 3. Compensatory Mechanisms\\\\n\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found. ', document_index=0, document_title='GENE: SMAD2', end_char_index=7603, start_char_index=0, type='char_location')], text='SMAD2 shows phenotypic enhancement with SMAD3', type='text'), TextBlock(citations=None, text=', and ', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. ', document_index=1, document_title='GENE: SMAD3', end_char_index=9580, start_char_index=0, type='char_location')], text='SMAD3 shows phenotypic enhancement with SMAD2', type='text'), TextBlock(citations=None, text=', suggesting functional redundancy that may limit single-target efficacy.\\\\n\\\\n### 4. Nuclear-Cytoplasmic Shuttling\\\\n\\\\n**SMAD2:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . ', document_index=0, document_title='GENE: SMAD2', end_char_index=19228, start_char_index=18833, type='char_location')], text='Cytoplasmic and nuclear in the absence of TGF-beta; migrates to nucleus when complexed with SMAD4 or IPO7 upon TGF-beta stimulation; released from complex and exported by RANBP1 upon dephosphorylation by PPM1A', type='text'), TextBlock(citations=None, text='.\\\\n\\\\n**SMAD3:**\\\\n', type='text'), TextBlock(citations=[CitationCharLocation(cited_text='*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . ', document_index=1, document_title='GENE: SMAD3', end_char_index=30724, start_char_index=30340, type='char_location')], text='Shows similar cytoplasmic-nuclear shuttling; migrates to nucleus when complexed with SMAD4; released and exported by RANBP1 through PPM1A action', type='text'), TextBlock(citations=None, text=\\\".\\\\n\\\\n**Implication:** Targeting nuclear import/export machinery or phosphatases (PPM1A) could modulate both proteins' activity.\\\\n\\\\n---\\\\n\\\\n## Summary and Recommendations\\\\n\\\\n### Druggability Ranking: SMAD3 > SMAD2\\\\n\\\\n**SMAD3 advantages:**\\\\n1. Validated small molecule inhibitors with nanomolar potency\\\\n2. Established screening assays and chemical starting points\\\\n3. Better characterized in fibrosis (clearer therapeutic indication)\\\\n\\\\n**SMAD2 advantages:**\\\\n1. Ligandable cysteines for covalent inhibitor development\\\\n2. Higher FPocket scores suggesting better pocket druggability\\\\n3. More tissue-restricted expression may reduce off-target effects\\\\n\\\\n### Recommended Targeting Approaches (Priority Order)\\\\n\\\\n1. **SMAD3 direct inhibition** (fibrosis, specific cancers)\\\\n - Build on existing nanomolar inhibitors\\\\n - Optimize for selectivity and pharmacokinetics\\\\n\\\\n2. **SMAD2 covalent inhibition** (cardiovascular, specific cancers)\\\\n - Target ligandable C74 or C81\\\\n - Develop selective covalent warheads\\\\n\\\\n3. **Dual SMAD2/3 PROTACs** (advanced cancers, severe fibrosis)\\\\n - Leverage endogenous E3 ligases (SMURF2, WWP2)\\\\n - Achieve complete pathway blockade\\\\n\\\\n4. **PPI disruption** (SMAD2/3-SMAD4 or co-factor interactions)\\\\n - Target heterotrimer formation\\\\n - Disrupt interactions with CREBBP/EP300\\\\n\\\\n5. **Upstream targeting** (TGF-β receptors, activating kinases)\\\\n - Indirect but clinically validated approach\\\\n - Affects both SMAD2 and SMAD3\\\\n\\\\n### Key Unresolved Issues\\\\n\\\\n1. **Selectivity:** Can SMAD2-selective or SMAD3-selective inhibitors be developed given structural similarity?\\\\n2. **Context-dependence:** How to stratify patients for tumor suppressor vs. pro-metastatic contexts?\\\\n3. **Redundancy:** Will single-target inhibition be sufficient or is dual targeting required?\\\\n4. **Biomarkers:** What pharmacodynamic markers can confirm target engagement in vivo?\\\\n5. **Resistance:** Will compensatory upregulation of parallel pathways limit efficacy?\\\\n\\\\n**Possible speculation:**\\\\n\\\\nGiven the existing SMAD3 inhibitors and SMAD2's ligandable cysteines, a rational drug development strategy might involve:\\\\n\\\\n1. **Near-term:** Optimize existing SMAD3 inhibitors for fibrosis indications where the therapeutic rationale is clearest\\\\n2. **Medium-term:** Develop SMAD2-selective covalent inhibitors targeting C74/C81 for cardiovascular indications (Loeys-Dietz syndrome)\\\\n3. **Long-term:** Create bifunctional degraders (PROTACs) for dual SMAD2/3 targeting in advanced cancers where complete pathway blockade is desired\\\\n\\\\nThe higher genetic constraint tolerance and non-essential status of both genes suggest that therapeutic inhibition may be feasible, though careful attention to tissue-specific and context-dependent effects will be critical for safety and efficacy.\\\", type='text')], model='claude-sonnet-4-5-20250929', role='assistant', stop_reason='end_turn', stop_sequence=None, type='message', usage=Usage(cache_creation_input_tokens=0, cache_read_input_tokens=0, input_tokens=47531, output_tokens=3916, server_tool_use=None, service_tier='standard', cache_creation={'ephemeral_5m_input_tokens': 0, 'ephemeral_1h_input_tokens': 0}))\\n[verify_evidence_node] start\\n*****************************************\\n[{'idx': 0, 'text': '# Druggability Comparison: SMAD2 vs SMAD3\\\\n\\\\n## Direct Druggability Evidence\\\\n\\\\n### SMAD2', 'proofs': []}, {'idx': 1, 'text': 'No ChEMBL druggability data found for SMAD2', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 2, 'text': ', indicating a lack of validated small molecule inhibitors or modulators in the ChEMBL database.\\\\n\\\\n### SMAD3', 'proofs': []}, {'idx': 3, 'text': 'SMAD3 has documented bioactivity evidence with 25 compounds showing IC50 values ranging from 38.00 nM to 9894.00 nM, with the most potent compounds being CHEMBL601757 (IC50=38.00 nM, pChEMBL=7.42) and CHEMBL1334062 (IC50=39.00 nM, pChEMBL=7.41)', 'proofs': [{'title': None, 'snippet': '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes - Bioactivity values are normalized to nM and aggregated per compound. - Only positive numeric IC50 / Ki / EC50 values with molar units were considered. - Reported values are the lowest (strongest) potency observed per assay type. - pChEMBL is -log10(molar potency): higher values = stronger activity.'}]}, {'idx': 4, 'text': '.', 'proofs': []}, {'idx': 5, 'text': 'Notable compounds include CHEMBL6246 (ELLAGIC ACID) with IC50=142.00 nM (pChEMBL=6.85)', 'proofs': [{'title': None, 'snippet': '*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00 *ChEMBL: Interpretation Notes - Bioactivity values are normalized to nM and aggregated per compound.'}]}, {'idx': 6, 'text': '.\\\\n\\\\n**Key Finding:** SMAD3 demonstrates significantly better druggability with validated small molecule inhibitors, while SMAD2 lacks such evidence.\\\\n\\\\n---\\\\n\\\\n## Structural Features Relevant to Druggability\\\\n\\\\n### Cysteine Residues (Potential Covalent Drug Targets)\\\\n\\\\n**SMAD2:**', 'proofs': []}, {'idx': 7, 'text': 'Has 14 detected cysteines, with 2 ligandable cysteines (Q15796_C74, Q15796_C81), 3 binding-site cysteines, and 2 near binding-site cysteines', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 8, 'text': '.\\\\n\\\\n**SMAD3:**', 'proofs': []}, {'idx': 9, 'text': 'Has only 5 detected cysteines, with 0 ligandable cysteines, though 3 are binding-site cysteines', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.'}]}, {'idx': 10, 'text': \\\".\\\\n\\\\n**Implication:** SMAD2's ligandable cysteines (C74 and C81) represent potential sites for covalent inhibitor development, offering a druggability advantage over SMAD3 for this approach.\\\\n\\\\n### Protein Disorder and Binding Regions\\\\n\\\\n**SMAD2:**\\\", 'proofs': []}, {'idx': 11, 'text': 'Shows 22.7% disordered regions with 3 disordered regions (longest=68 residues) and 14.1% high MoRF propensity (longest segment=66 residues)', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 12, 'text': '.\\\\n\\\\n**SMAD3:**', 'proofs': []}, {'idx': 13, 'text': 'Shows 22.6% disordered regions with 4 disordered regions (longest=67 residues) and 13.9% high MoRF propensity (longest segment=59 residues)', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.'}]}, {'idx': 14, 'text': '.\\\\n\\\\n**Implication:** Both proteins have similar disorder profiles, suggesting comparable challenges for traditional small molecule binding but potential opportunities for targeting protein-protein interactions through MoRF regions.\\\\n\\\\n### Druggable Pockets\\\\n\\\\n**SMAD2:**', 'proofs': []}, {'idx': 15, 'text': 'FPocket scores range from 0.0 to 0.713 (avg=0.037)', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 16, 'text': ', with the maximum suggesting at least one potentially druggable pocket.\\\\n\\\\n**SMAD3:**', 'proofs': []}, {'idx': 17, 'text': 'FPocket scores range from 0.0 to 0.136 (avg=0.010)', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.'}]}, {'idx': 18, 'text': ', indicating lower overall pocket druggability.\\\\n\\\\n---\\\\n\\\\n## Targeting Strategies\\\\n\\\\n### 1. Direct Small Molecule Inhibition\\\\n\\\\n**Current Status:**\\\\n- **SMAD3:** Validated approach with nanomolar inhibitors available\\\\n- **SMAD2:** No validated small molecules reported\\\\n\\\\n**Challenges:**\\\\n- Both proteins function as transcription factors, traditionally considered \\\"undruggable\\\"\\\\n- High structural similarity between SMAD2 and SMAD3 may complicate selectivity\\\\n\\\\n### 2. Protein-Protein Interaction (PPI) Disruption\\\\n\\\\nBoth proteins form critical complexes:\\\\n\\\\n**SMAD2 interactions:**', 'proofs': []}, {'idx': 19, 'text': 'Forms heteromeric SMAD protein complexes and interacts with SMAD3, SMAD4, and numerous co-factors including CREBBP, EP300, SKI, SKIL', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 20, 'text': '.\\\\n\\\\n**SMAD3 interactions:**', 'proofs': []}, {'idx': 21, 'text': 'Interacts with SMAD2, SMAD4, and similar co-factors, with documented co-crystal structures with SMAD3, SMAD4, and ZFYVE9', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.'}]}, {'idx': 22, 'text': '.\\\\n\\\\n**Targeting opportunities:**\\\\n- SMAD2/3-SMAD4 heterotrimer formation\\\\n- Interactions with transcriptional co-activators (CREBBP, EP300)\\\\n- Interactions with inhibitory proteins (SKI, SKIL)\\\\n\\\\n### 3. Covalent Inhibitor Development', 'proofs': []}, {'idx': 23, 'text': \\\"SMAD2's two ligandable cysteines (C74, C81) near binding sites\\\", 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 24, 'text': 'represent attractive targets for covalent inhibitors, potentially offering:\\\\n- Improved selectivity over SMAD3\\\\n- Enhanced potency through irreversible binding\\\\n- Longer duration of action\\\\n\\\\n### 4. Targeting Post-Translational Modifications\\\\n\\\\nBoth proteins undergo extensive regulation:\\\\n\\\\n**SMAD2:**', 'proofs': []}, {'idx': 25, 'text': 'Participates in pathways including \\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\" and \\\"Post-translational protein modification\\\"', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 26, 'text': '.\\\\n\\\\n**SMAD3:**', 'proofs': []}, {'idx': 27, 'text': 'Shows biochemical activity with multiple kinases (CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1) and deubiquitinases (OTUB1, USP15, USP7)', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.'}]}, {'idx': 28, 'text': '.\\\\n\\\\n**Targeting strategies:**\\\\n- Inhibit activating kinases (TGFBR1)\\\\n- Inhibit CDKs that phosphorylate linker regions\\\\n- Target E3 ubiquitin ligases (SMURF1, SMURF2, WWP2)\\\\n- Inhibit deubiquitinases to promote degradation\\\\n\\\\n### 5. Targeted Protein Degradation (PROTACs/Molecular Glues)\\\\n\\\\n**Advantages:**\\\\n- Circumvents need for traditional binding pockets\\\\n- Can achieve selectivity through E3 ligase recruitment\\\\n- Particularly attractive for SMAD2 given lack of direct inhibitors\\\\n\\\\n**Feasibility:**', 'proofs': []}, {'idx': 29, 'text': 'SMAD2 interacts with multiple E3 ligases including SMURF2, WWP2, ITCH, NEDD4, NEDD4L', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 30, 'text': ', and', 'proofs': []}, {'idx': 31, 'text': 'SMAD3 shows similar interactions with NEDD4, NEDD4L, SMURF1, SMURF2, WWP2', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.'}]}, {'idx': 32, 'text': ', providing natural degradation pathways to exploit.\\\\n\\\\n---\\\\n\\\\n## Existing Therapeutic Approaches\\\\n\\\\n### Indirect Targeting via TGF-β Pathway\\\\n\\\\nBoth proteins are downstream of TGF-β receptor signaling:\\\\n\\\\n**SMAD2:**', 'proofs': []}, {'idx': 33, 'text': 'Participates in \\\"TGF-beta receptor signaling activates SMADs\\\" and \\\"Signaling by TGF-beta Receptor Complex\\\"', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 34, 'text': '.\\\\n\\\\n**SMAD3:**', 'proofs': []}, {'idx': 35, 'text': 'Similarly involved in TGF-β receptor signaling pathways', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.'}]}, {'idx': 36, 'text': '.\\\\n\\\\n**Clinical relevance:**\\\\n- TGF-β receptor inhibitors (e.g., galunisertib) indirectly block SMAD2/3 activation\\\\n- This approach affects both proteins simultaneously, limiting selectivity\\\\n\\\\n---\\\\n\\\\n## Disease Context and Therapeutic Potential\\\\n\\\\n### SMAD2 Disease Associations', 'proofs': []}, {'idx': 37, 'text': 'SMAD2 is associated with Loeys-Dietz syndrome 6, congenital heart defects, multiple types, 8, with or without heterotaxy, and numerous cancers including colorectal adenocarcinoma, glioblastoma, and breast cancer', 'proofs': [{'title': None, 'snippet': \\\"*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm.\\\"}]}, {'idx': 38, 'text': '.\\\\n\\\\n### SMAD3 Disease Associations', 'proofs': []}, {'idx': 39, 'text': 'SMAD3 is associated with Colorectal cancer and Loeys-Dietz syndrome 3', 'proofs': [{'title': None, 'snippet': 'Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.'}]}, {'idx': 40, 'text': ', plus', 'proofs': []}, {'idx': 41, 'text': 'extensive associations with cardiovascular diseases, fibrotic conditions, autoimmune diseases, and various cancers', 'proofs': [{'title': None, 'snippet': \\\"*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infa…\\\"}]}, {'idx': 42, 'text': '.\\\\n\\\\n**Therapeutic implications:**\\\\n- **Cancer:** Both are tumor suppressors; inhibition may be contraindicated\\\\n- **Fibrosis:** SMAD3 inhibition shows promise (existing compounds available)\\\\n- **Cardiovascular disease:** Context-dependent; may require selective modulation\\\\n\\\\n---\\\\n\\\\n## Genetic Constraint and Safety Considerations\\\\n\\\\n### Loss-of-Function Tolerance\\\\n\\\\n**SMAD2:**', 'proofs': []}, {'idx': 43, 'text': 'Genetic constraint score for lof variants: 1.0 (mapped to LOEUF rank, lower = less tolerant)', 'proofs': [{'title': None, 'snippet': \\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0 *HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall.\\\"}]}, {'idx': 44, 'text': '.\\\\n\\\\n**SMAD3:**', 'proofs': []}, {'idx': 45, 'text': 'Genetic constraint score for lof variants: 0.9999799728393555', 'proofs': [{'title': None, 'snippet': \\\"*OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555 *GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\\\"}]}, {'idx': 46, 'text': '.\\\\n\\\\n**Interpretation:** Both proteins show high constraint scores (~1.0), indicating that loss-of-function variants are relatively well-tolerated in the population, suggesting potential safety for therapeutic inhibition.\\\\n\\\\n### Essentiality', 'proofs': []}, {'idx': 47, 'text': 'SMAD2 is not a core essential gene', 'proofs': [{'title': None, 'snippet': '*OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).'}]}, {'idx': 48, 'text': ', and', 'proofs': []}, {'idx': 49, 'text': 'SMAD3 is not a core essential gene', 'proofs': [{'title': None, 'snippet': '*OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival).'}]}, {'idx': 50, 'text': ', indicating that complete inhibition may be tolerated, though context-dependent effects are likely.\\\\n\\\\n---\\\\n\\\\n## Tissue-Specific Expression Considerations\\\\n\\\\n### SMAD2', 'proofs': []}, {'idx': 51, 'text': 'Shows high tissue-specific expression (z-score ≥2) in: segmented neutrophil of bone marrow (z=4), CD34-negative megakaryocyte cell (z=4), CD8-positive alpha-beta T cell (z=3), CD4-positive alpha-beta T cell (z=3), common lymphoid progenitor (z=3), conventional dendritic cell (z=4), CD4-positive alpha-beta thymocyte (z=5), CD8-positive alpha-beta thymocyte (z=4)', 'proofs': [{'title': None, 'snippet': '*OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'frontal lobe\\\\': -1, \\\\'endothelial cell of umbilical vein (resting)\\\\': 2, \\\\'zone of skin\\\\': 0, \\\\'regulatory T cell\\\\': 1, \\\\'pancreas\\\\': -1, \\\\'suprapubic skin\\\\': -1, \\\\'temporal lobe\\\\': -1, \\\\'parathyroid gland\\\\': -1, \\\\'spleen\\\\': -1, \\\\'Brodmann (1909) area 9\\\\': -1, \\\\'breast\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': -1, \\\\'alternatively activated macrophage\\\\': 2, \\\\'segmented neutrophil of bone marrow\\\\': 4, \\\\'placenta\\\\': -1, \\\\'mature eosinophil\\\\': 1, \\\\'granulocyte monocyte progenitor cell\\\\': 0, \\\\'gall bladder\\\\': -1, \\\\'esophagus muscularis mucosa\\\\': -1, \\\\'seminal vesicle\\\\': -1, \\\\'endocervix\\\\': -1, \\\\'lower leg skin\\\\': -1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 2, \\\\'CD8-positive, alpha-beta T cell\\\\': 3, \\\\'cerebral cortex\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': 4, \\\\'hippocampus proper\\\\': -1, \\\\'uterus\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': 3, \\\\'tonsil\\\\': -1, \\\\'esophagus\\\\': 0, \\\\'transverse colon\\\\': -1, \\\\'pituitary gland\\\\': -1, \\\\'coronary artery\\\\': -1, \\\\'memory B cell\\\\': 0, \\\\'sigmoid colon\\\\': -1, \\\\'cerebellum\\\\': -1, \\\\'erythroblast\\\\': 2, \\\\'prefrontal cortex\\\\': -1, \\\\'nucleus accumbens\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'vermiform appendix\\\\': -1, \\\\'greater omentum\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': 1, \\\\'leukocyte\\\\': 2, \\\\'adrenal gland\\\\': -1, \\\\'atrium auricular region\\\\': -1, \\\\'thyroid gland\\\\': 0, \\\\'tibial artery\\\\': -1, \\\\'common lymphoid progenitor\\\\': 3, \\\\'urinary bladder\\\\': -1, \\\\'duodenum\\\\': -1, \\\\'heart muscle\\\\': -1, \\\\'small intestine\\\\': -1, \\\\'neutrophilic metamyelocyte\\\\': 3, \\\\'minor salivary gland\\\\': -1, \\\\'rectum\\\\': 0, \\\\'ovary\\\\': -1, \\\\'substantia nigra\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': -1, \\\\'class switched memory B cell\\\\': 1, \\\\'fallopian tube\\\\': -1, \\\\'esophagus mucosa\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 0, \\\\'bronchus\\\\': -1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": -1, \\\\'kidney\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'macrophage\\\\': 1, \\\\'aorta\\\\': -1, \\\\'skeletal muscle tissue\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': 4, \\\\'caudate-putamen\\\\': -1, \\\\'liver\\\\': -1, \\\\'cytotoxic CD56-dim natural killer cell\\\\': 2, \\\\'mature neutrophil\\\\': 2, \\\\'hypothalamus\\\\': -1, \\\\'transformed skin fibroblast\\\\': -1, \\\\'bone marrow\\\\': -1, \\\\'inflammatory macrophage\\\\': 0, \\\\'cortex of kidney\\\\': -1, \\\\'lung\\\\': -1, \\\\'epididymis\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'saliva-secreting gland\\\\': -1, \\\\'nasopharynx\\\\': -1, \\\\'colon\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'stomach\\\\': -1, \\\\'testis\\\\': -1, \\\\'smooth muscle tissue\\\\': 0, \\\\'putamen\\\\': -1, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 5, \\\\'C1 segment of cervical spinal cord\\\\': 0, \\\\'blood\\\\': -1, \\\\'hematopoietic stem cell\\\\': 1, \\\\'caudate nucleus\\\\': -1, \\\\'amygdala\\\\': -1, \\\\'brain\\\\': 0, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'ectocervix\\\\': -1, \\\\'prostate gland\\\\': -1, \\\\'conventional dendritic cell\\\\': 4, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 1, \\\\'heart left ventricle\\\\': -1, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 0, \\\\'vagina\\\\': -1, \\\\'esophagogastric junction\\\\': -1, \\\\'lymph node\\\\': -1, \\\\'endometrium\\\\': -1, \\\\'heart\\\\': -1, \\\\'oral mucosa\\\\': -1, \\\\'CD8-positive, alpha-beta thymocyte\\\\': 4, \\\\'common myeloid progenitor\\\\': 0, \\\\'tibial nerve\\\\': -1, \\\\'plasma cell\\\\': -1}.'}]}, {'idx': 52, 'text': '.\\\\n\\\\n### SMAD3', 'proofs': []}, {'idx': 53, 'text': 'Shows high tissue-specific expression in: CD14-positive, CD16-negative classical monocyte (z=3)', 'proofs': [{'title': None, 'snippet': '*OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {\\\\'breast\\\\': 0, \\\\'atrium auricular region\\\\': 1, \\\\'liver\\\\': 0, \\\\'skeletal muscle tissue\\\\': 1, \\\\'EBV-transformed lymphocyte\\\\': 0, \\\\'esophagus mucosa\\\\': 1, \\\\'macrophage\\\\': -1, \\\\'adipose tissue\\\\': 0, \\\\'segmented neutrophil of bone marrow\\\\': -1, \\\\'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\\': -1, \\\\'class switched memory B cell\\\\': 0, \\\\'CD14-positive, CD16-negative classical monocyte\\\\': 3, \\\\'Brodmann (1909) area 9\\\\': 0, \\\\'CD4-positive, alpha-beta thymocyte\\\\': 1, \\\\'zone of skin\\\\': 1, \\\\'leukocyte\\\\': 0, \\\\'nasopharynx\\\\': -1, \\\\'tonsil\\\\': 0, \\\\'frontal lobe\\\\': 0, \\\\'cerebellar hemisphere\\\\': -1, \\\\'putamen\\\\': 0, \\\\'hematopoietic stem cell\\\\': -1, \\\\'effector memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'testis\\\\': -1, \\\\'bronchus\\\\': -1, \\\\'sigmoid colon\\\\': 0, \\\\'fallopian tube\\\\': 0, \\\\'plasma cell\\\\': -1, \\\\'aorta\\\\': 0, \\\\'adrenal gland\\\\': -1, \\\\'kidney\\\\': 0, \\\\'endometrium\\\\': 0, \\\\'smooth muscle tissue\\\\': 0, \\\\'tibial artery\\\\': 0, \\\\'prefrontal cortex\\\\': 0, \\\\'CD8-positive, alpha-beta T cell\\\\': -1, \\\\'vermiform appendix\\\\': 0, \\\\'lymph node\\\\': 0, \\\\'duodenum\\\\': 0, \\\\'mature eosinophil\\\\': 0, \\\\'prostate gland\\\\': 1, \\\\'C1 segment of cervical spinal cord\\\\': -1, \\\\'lung\\\\': 0, \\\\'inflammatory macrophage\\\\': -1, \\\\'rectum\\\\': 0, \\\\'suprapubic skin\\\\': 0, \\\\'brain\\\\': -1, \\\\'coronary artery\\\\': 0, \\\\'parathyroid gland\\\\': -1, \\\\'Brodmann (1909) area 24\\\\': 0, \\\\'esophagus muscularis mucosa\\\\': 0, \\\\'esophagus\\\\': 1, \\\\'transformed skin fibroblast\\\\': 1, \\\\'heart muscle\\\\': -1, \\\\'pancreas\\\\': 0, \\\\'uterus\\\\': 0, \\\\'placenta\\\\': 0, \\\\'seminal vesicle\\\\': -1, \\\\'hippocampus\\\\': -1, \\\\'effector memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'endothelial cell of umbilical vein (resting)\\\\': 0, \\\\'minor salivary gland\\\\': 0, \\\\'endocervix\\\\': 1, \\\\'central memory CD8-positive, alpha-beta T cell\\\\': 0, \\\\'CD8-positive, alpha-beta thymocyte\\\\': -1, \\\\'granulocyte monocyte progenitor cell\\\\': -1, \\\\'caudate nucleus\\\\': 0, \\\\'amygdala\\\\': 0, \\\\'temporal lobe\\\\': 0, \\\\'substantia nigra\\\\': -1, \\\\'abdomen\\\\': -1, \\\\'common lymphoid progenitor\\\\': 0, \\\\'cerebral cortex\\\\': 0, \\\\'endothelial cell of umbilical vein (proliferating)\\\\': 0, \\\\'blood\\\\': -1, \\\\'nucleus accumbens\\\\': 0, \\\\'stomach\\\\': 0, \\\\'oral mucosa\\\\': -1, \\\\'mature neutrophil\\\\': 0, \\\\'central memory CD4-positive, alpha-beta T cell\\\\': 0, \\\\'bone marrow\\\\': -1, \\\\'gall bladder\\\\': 1, \\\\'colon\\\\': 0, \\\\'cytotoxic CD56-dim natural killer cell\\\\': -1, \\\\'pituitary gland\\\\': 0, \\\\'transverse colon\\\\': 0, \\\\'heart left ventricle\\\\': 0, \\\\'erythroblast\\\\': -1, \\\\'vagina\\\\': 1, \\\\'ovary\\\\': 1, \\\\'megakaryocyte-erythroid progenitor cell\\\\': -1, \\\\'subcutaneous adipose tissue\\\\': 1, \\\\'cerebellum\\\\': -1, \\\\'hypothalamus\\\\': -1, \\\\'common myeloid progenitor\\\\': -1, \\\\'hematopoietic multipotent progenitor cell\\\\': -1, \\\\'alternatively activated macrophage\\\\': -1, \\\\'thyroid gland\\\\': 1, \\\\'lower leg skin\\\\': 0, \\\\'epididymis\\\\': -1, \\\\'spleen\\\\': 0, \\\\'esophagogastric junction\\\\': 0, \\\\'greater omentum\\\\': 1, \\\\'memory B cell\\\\': 0, \\\\'hippocampus proper\\\\': -1, \\\\'CD4-positive, alpha-beta T cell\\\\': -1, \\\\'small intestine\\\\': 1, \\\\'conventional dendritic cell\\\\': -1, \\\\'cortex of kidney\\\\': 0, \\\"small intestine Peyer\\\\'s patch\\\": 0, \\\\'heart\\\\': -1, \\\\'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\\': -1, \\\\'caudate-putamen\\\\': -1, \\\\'urinary bladder\\\\': 1, \\\\'ectocervix\\\\': 1, \\\\'regulatory T cell\\\\': -1, \\\\'CD38-negative naive B cell\\\\': 1, \\\\'saliva-secreting gland\\\\': 0, \\\\'neutrophilic metamyelocyte\\\\': -1, \\\\'tibial nerve\\\\': 0}.'}]}, {'idx': 54, 'text': \\\", with generally lower tissue specificity than SMAD2.\\\\n\\\\n**Implication:** SMAD2's higher expression in immune cells may complicate systemic inhibition due to immunological effects, while SMAD3's broader expression pattern may present different toxicity concerns.\\\\n\\\\n---\\\\n\\\\n## Challenges and Considerations\\\\n\\\\n### 1. Selectivity Between SMAD2 and SMAD3\\\\n\\\\n- High structural similarity (both R-SMADs)\\\\n- Overlapping functions in TGF-β signaling\\\\n-\\\", 'proofs': []}, {'idx': 55, 'text': 'Both form SMAD2/SMAD3:SMAD4 heterotrimers', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 56, 'text': '- Selective inhibition may require exploiting unique interaction surfaces or post-translational modification sites\\\\n\\\\n### 2. Context-Dependent Functions\\\\n\\\\n**Tumor suppressor vs. oncogenic roles:**\\\\n- In early cancer stages: tumor suppressive (inhibition contraindicated)\\\\n- In advanced cancer/metastasis: pro-metastatic (inhibition beneficial)\\\\n- Requires careful patient stratification\\\\n\\\\n### 3. Compensatory Mechanisms', 'proofs': []}, {'idx': 57, 'text': 'SMAD2 shows phenotypic enhancement with SMAD3', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796 Transcripts: n_transcripts=0: Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2 Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9 Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1 Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9 Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1 Interactions from human data (Co-crystal Structure): SMAD4 Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9 Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53 Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1 Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): SPPL3 Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2 Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9 Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1 Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1 Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4 Interactions from additional (non-human) data: (PCA): E6, SMOX Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128 Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74 *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.'}]}, {'idx': 58, 'text': ', and', 'proofs': []}, {'idx': 59, 'text': 'SMAD3 shows phenotypic enhancement with SMAD2', 'proofs': [{'title': None, 'snippet': 'Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022 Transcripts: n_transcripts=0: Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1 Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1 Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25 Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1 Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2 Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9 Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9 Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62 Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A Interactions from human data (FRET): SMAD4, STUB1 Interactions from human data (PCA): SMAD4, SMAD7 Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1 Interactions from human data (Phenotypic Suppression): SMAD7, STRAP Interactions from human data (Positive Genetic): JAK1 Interactions from human data (Protein-RNA): LINC00941 Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1 Interactions from human data (Proximity Label-MS): NFIA Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1 Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83 Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2 Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3 Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1 Interactions from additional (non-human) data: (Co-localization): E7, N Interactions from additional (non-human) data: (PCA): E6 Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A Interactions from additional (non-human) data: (Proximity Label-MS): M Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128 Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9 Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2 *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0 *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket.'}]}, {'idx': 60, 'text': ', suggesting functional redundancy that may limit single-target efficacy.\\\\n\\\\n### 4. Nuclear-Cytoplasmic Shuttling\\\\n\\\\n**SMAD2:**', 'proofs': []}, {'idx': 61, 'text': 'Cytoplasmic and nuclear in the absence of TGF-beta; migrates to nucleus when complexed with SMAD4 or IPO7 upon TGF-beta stimulation; released from complex and exported by RANBP1 upon dephosphorylation by PPM1A', 'proofs': [{'title': None, 'snippet': '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 .'}]}, {'idx': 62, 'text': '.\\\\n\\\\n**SMAD3:**', 'proofs': []}, {'idx': 63, 'text': 'Shows similar cytoplasmic-nuclear shuttling; migrates to nucleus when complexed with SMAD4; released and exported by RANBP1 through PPM1A action', 'proofs': [{'title': None, 'snippet': '*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 .'}]}, {'idx': 64, 'text': \\\".\\\\n\\\\n**Implication:** Targeting nuclear import/export machinery or phosphatases (PPM1A) could modulate both proteins' activity.\\\\n\\\\n---\\\\n\\\\n## Summary and Recommendations\\\\n\\\\n### Druggability Ranking: SMAD3 > SMAD2\\\\n\\\\n**SMAD3 advantages:**\\\\n1. Validated small molecule inhibitors with nanomolar potency\\\\n2. Established screening assays and chemical starting points\\\\n3. Better characterized in fibrosis (clearer therapeutic indication)\\\\n\\\\n**SMAD2 advantages:**\\\\n1. Ligandable cysteines for covalent inhibitor development\\\\n2. Higher FPocket scores suggesting better pocket druggability\\\\n3. More tissue-restricted expression may reduce off-target effects\\\\n\\\\n### Recommended Targeting Approaches (Priority Order)\\\\n\\\\n1. **SMAD3 direct inhibition** (fibrosis, specific cancers)\\\\n - Build on existing nanomolar inhibitors\\\\n - Optimize for selectivity and pharmacokinetics\\\\n\\\\n2. **SMAD2 covalent inhibition** (cardiovascular, specific cancers)\\\\n - Target ligandable C74 or C81\\\\n - Develop selective covalent warheads\\\\n\\\\n3. **Dual SMAD2/3 PROTACs** (advanced cancers, severe fibrosis)\\\\n - Leverage endogenous E3 ligases (SMURF2, WWP2)\\\\n - Achieve complete pathway blockade\\\\n\\\\n4. **PPI disruption** (SMAD2/3-SMAD4 or co-factor interactions)\\\\n - Target heterotrimer formation\\\\n - Disrupt interactions with CREBBP/EP300\\\\n\\\\n5. **Upstream targeting** (TGF-β receptors, activating kinases)\\\\n - Indirect but clinically validated approach\\\\n - Affects both SMAD2 and SMAD3\\\\n\\\\n### Key Unresolved Issues\\\\n\\\\n1. **Selectivity:** Can SMAD2-selective or SMAD3-selective inhibitors be developed given structural similarity?\\\\n2. **Context-dependence:** How to stratify patients for tumor suppressor vs. pro-metastatic contexts?\\\\n3. **Redundancy:** Will single-target inhibition be sufficient or is dual targeting required?\\\\n4. **Biomarkers:** What pharmacodynamic markers can confirm target engagement in vivo?\\\\n5. **Resistance:** Will compensatory upregulation of parallel pathways limit efficacy?\\\\n\\\\n**Possible speculation:**\\\\n\\\\nGiven the existing SMAD3 inhibitors and SMAD2's ligandable cysteines, a rational drug development strategy might involve:\\\\n\\\\n1. **Near-term:** Optimize existing SMAD3 inhibitors for fibrosis indications where the therapeutic rationale is clearest\\\\n2. **Medium-term:** Develop SMAD2-selective covalent inhibitors targeting C74/C81 for cardiovascular indications (Loeys-Dietz syndrome)\\\\n3. **Long-term:** Create bifunctional degraders (PROTACs) for dual SMAD2/3 targeting in advanced cancers where complete pathway blockade is desired\\\\n\\\\nThe higher genetic constraint tolerance and non-essential status of both genes suggest that therapeutic inhibition may be feasible, though careful attention to tissue-specific and context-dependent effects will be critical for safety and efficacy.\\\", 'proofs': []}]\\n[verify_evidence_node] verdict: pass summary: {'supported': 52, 'partial': 12, 'unsupported': 0}\\n=== END ===\\n\"],[\"20251224-191245_ui/genes/genes.index.csv\",\"symbol,gene_type,entrez_id,uniprot_id,ensembl_id,chrom,start,end,strand,n_transcripts,has_gwas,gwas_total,n_variants,n_interaction_partners,n_binding_peaks,n_mirna_targets,n_traits,tools_run,summary_relpath,json_relpath,transcripts_relpath,interactions_human_relpath,interactions_nonhuman_relpath\\r\\nSMAD2,,4087,Q15796,,,,,,0,0,0,0,317,0,0,0,EntityExtraction;MSigDB;uniprot_entry;BioGRID;OpenTargets;reactome_pathways;humanbase_predictions,genes/SMAD2/summary.txt,genes/SMAD2/gene.json,genes/SMAD2/transcripts.tsv,genes/SMAD2/interactions_human.tsv,genes/SMAD2/interactions_nonhuman.tsv\\r\\nSMAD3,,4088,P84022,,,,,,0,0,0,0,391,0,0,0,EntityExtraction;MSigDB;uniprot_entry;BioGRID;OpenTargets;reactome_pathways;humanbase_predictions,genes/SMAD3/summary.txt,genes/SMAD3/gene.json,genes/SMAD3/transcripts.tsv,genes/SMAD3/interactions_human.tsv,genes/SMAD3/interactions_nonhuman.tsv\\r\\n\"],[\"20251224-191245_ui/genes/SMAD3/interactions_nonhuman.tsv\",\"experiment_type\\tpartner_symbol\\r\\nAffinity Capture-Luminescence\\tARHGEF6\\r\\nAffinity Capture-Luminescence\\tARHGEF7\\r\\nAffinity Capture-Luminescence\\tCLASRP\\r\\nAffinity Capture-Luminescence\\tFBXO3\\r\\nAffinity Capture-Luminescence\\tGSC\\r\\nAffinity Capture-Luminescence\\tMAP2K3\\r\\nAffinity Capture-Luminescence\\tPPP2R2D\\r\\nAffinity Capture-Luminescence\\tRAB38\\r\\nAffinity Capture-Luminescence\\tRASD2\\r\\nAffinity Capture-Luminescence\\tRGS3\\r\\nAffinity Capture-Luminescence\\tRRAS2\\r\\nAffinity Capture-Luminescence\\tSMAD2\\r\\nAffinity Capture-Luminescence\\tSMAD3\\r\\nAffinity Capture-Luminescence\\tSQSTM1\\r\\nAffinity Capture-Luminescence\\tTRIM35\\r\\nAffinity Capture-Luminescence\\tWEE1\\r\\nAffinity Capture-Luminescence\\tWWP2\\r\\nAffinity Capture-MS\\tATG16L1\\r\\nAffinity Capture-MS\\tE6\\r\\nAffinity Capture-MS\\tNSP6\\r\\nAffinity Capture-MS\\tOTUB1\\r\\nAffinity Capture-MS\\tSMAD3\\r\\nAffinity Capture-Western\\tAXIN1\\r\\nAffinity Capture-Western\\tCOL1A1\\r\\nAffinity Capture-Western\\tCOL3A1\\r\\nAffinity Capture-Western\\tCOL5A1\\r\\nAffinity Capture-Western\\tDDX5\\r\\nAffinity Capture-Western\\tDOK1\\r\\nAffinity Capture-Western\\tE6\\r\\nAffinity Capture-Western\\tE7\\r\\nAffinity Capture-Western\\tEP300\\r\\nAffinity Capture-Western\\tGATA4\\r\\nAffinity Capture-Western\\tGNB2L1\\r\\nAffinity Capture-Western\\tHCVGP1\\r\\nAffinity Capture-Western\\tHDAC4\\r\\nAffinity Capture-Western\\tKLF4\\r\\nAffinity Capture-Western\\tMED15\\r\\nAffinity Capture-Western\\tMELK\\r\\nAffinity Capture-Western\\tN\\r\\nAffinity Capture-Western\\tRNF111\\r\\nAffinity Capture-Western\\tSKI\\r\\nAffinity Capture-Western\\tSMAD3\\r\\nAffinity Capture-Western\\tSMAD3A\\r\\nAffinity Capture-Western\\tSMAD4\\r\\nAffinity Capture-Western\\tTGFB1I1\\r\\nAffinity Capture-Western\\tTOB1\\r\\nAffinity Capture-Western\\tTOB1A\\r\\nAffinity Capture-Western\\tTOB1B\\r\\nAffinity Capture-Western\\tVDR\\r\\nAffinity Capture-Western\\tZEB1\\r\\nCo-localization\\tE7\\r\\nCo-localization\\tN\\r\\nPCA\\tE6\\r\\nPhenotypic Enhancement\\tSMAD3A\\r\\nPhenotypic Suppression\\tSMAD3A\\r\\nProximity Label-MS\\tM\\r\\nReconstituted Complex\\tE6\\r\\nReconstituted Complex\\tE7\\r\\nReconstituted Complex\\tGATA4\\r\\nReconstituted Complex\\tN\\r\\nReconstituted Complex\\tSIN3A\\r\\nReconstituted Complex\\tSMAD3\\r\\nReconstituted Complex\\tSOX9\\r\\nReconstituted Complex\\tYAP1\\r\\nReconstituted Complex\\tZFP128\\r\\nSynthetic Growth Defect\\tMMP9\\r\\nTwo-hybrid\\tDVL1\\r\\nTwo-hybrid\\tE6\\r\\nTwo-hybrid\\tERBB2IP\\r\\nTwo-hybrid\\tFOXH1\\r\\nTwo-hybrid\\tGATA4\\r\\nTwo-hybrid\\tHCVGP1\\r\\nTwo-hybrid\\tJUN\\r\\nTwo-hybrid\\tMAGI2\\r\\nTwo-hybrid\\tPARD3\\r\\nTwo-hybrid\\tSMAD3\\r\\nTwo-hybrid\\tZEB2\\r\\n\"],[\"20251224-191245_ui/genes/SMAD3/interactions_human.tsv\",\"experiment_type\\tpartner_symbol\\r\\nAffinity Capture-Luminescence\\tBAG3\\r\\nAffinity Capture-Luminescence\\tHIF1A\\r\\nAffinity Capture-Luminescence\\tSMAD2\\r\\nAffinity Capture-Luminescence\\tSMAD4\\r\\nAffinity Capture-Luminescence\\tSMURF1\\r\\nAffinity Capture-Luminescence\\tSMURF2\\r\\nAffinity Capture-Luminescence\\tSP1\\r\\nAffinity Capture-MS\\tARID1A\\r\\nAffinity Capture-MS\\tATG14\\r\\nAffinity Capture-MS\\tATG16L1\\r\\nAffinity Capture-MS\\tATXN2L\\r\\nAffinity Capture-MS\\tBUB3\\r\\nAffinity Capture-MS\\tC1ORF116\\r\\nAffinity Capture-MS\\tCD6\\r\\nAffinity Capture-MS\\tCDK11A\\r\\nAffinity Capture-MS\\tCHD8\\r\\nAffinity Capture-MS\\tCIC\\r\\nAffinity Capture-MS\\tCREBBP\\r\\nAffinity Capture-MS\\tCSNK1D\\r\\nAffinity Capture-MS\\tCTNNB1\\r\\nAffinity Capture-MS\\tDCAF4\\r\\nAffinity Capture-MS\\tDCAF7\\r\\nAffinity Capture-MS\\tDDX3X\\r\\nAffinity Capture-MS\\tDDX3Y\\r\\nAffinity Capture-MS\\tDDX4\\r\\nAffinity Capture-MS\\tDHX8\\r\\nAffinity Capture-MS\\tDNAJA2\\r\\nAffinity Capture-MS\\tDOCK9\\r\\nAffinity Capture-MS\\tDYRK1A\\r\\nAffinity Capture-MS\\tDZIP3\\r\\nAffinity Capture-MS\\tEPB41L5\\r\\nAffinity Capture-MS\\tERBB2IP\\r\\nAffinity Capture-MS\\tEVA1B\\r\\nAffinity Capture-MS\\tEZH2\\r\\nAffinity Capture-MS\\tFAM83G\\r\\nAffinity Capture-MS\\tFURIN\\r\\nAffinity Capture-MS\\tHINT3\\r\\nAffinity Capture-MS\\tHSPA4\\r\\nAffinity Capture-MS\\tIRF7\\r\\nAffinity Capture-MS\\tIRS1\\r\\nAffinity Capture-MS\\tITGB4\\r\\nAffinity Capture-MS\\tKAT6A\\r\\nAffinity Capture-MS\\tKCTD16\\r\\nAffinity Capture-MS\\tLACRT\\r\\nAffinity Capture-MS\\tLDLRAD4\\r\\nAffinity Capture-MS\\tLEMD3\\r\\nAffinity Capture-MS\\tLRCH1\\r\\nAffinity Capture-MS\\tLSR\\r\\nAffinity Capture-MS\\tMAP2K3\\r\\nAffinity Capture-MS\\tMAPK1\\r\\nAffinity Capture-MS\\tMED16\\r\\nAffinity Capture-MS\\tMED4\\r\\nAffinity Capture-MS\\tNCOA3\\r\\nAffinity Capture-MS\\tNF2\\r\\nAffinity Capture-MS\\tOPA1\\r\\nAffinity Capture-MS\\tOTUB1\\r\\nAffinity Capture-MS\\tOTUD1\\r\\nAffinity Capture-MS\\tPABPC1\\r\\nAffinity Capture-MS\\tPARK2\\r\\nAffinity Capture-MS\\tPJA1\\r\\nAffinity Capture-MS\\tPLEKHA4\\r\\nAffinity Capture-MS\\tPPIE\\r\\nAffinity Capture-MS\\tPRNP\\r\\nAffinity Capture-MS\\tPSPC1\\r\\nAffinity Capture-MS\\tPTPN6\\r\\nAffinity Capture-MS\\tRAB11FIP5\\r\\nAffinity Capture-MS\\tRPL3\\r\\nAffinity Capture-MS\\tRPL4\\r\\nAffinity Capture-MS\\tRPSAP15\\r\\nAffinity Capture-MS\\tSIK3\\r\\nAffinity Capture-MS\\tSLC25A12\\r\\nAffinity Capture-MS\\tSLC9A3R2\\r\\nAffinity Capture-MS\\tSMAD1\\r\\nAffinity Capture-MS\\tSMAD2\\r\\nAffinity Capture-MS\\tSMAD4\\r\\nAffinity Capture-MS\\tSMAD5\\r\\nAffinity Capture-MS\\tSMAD9\\r\\nAffinity Capture-MS\\tSMARCA4\\r\\nAffinity Capture-MS\\tSMARCC1\\r\\nAffinity Capture-MS\\tSMARCC2\\r\\nAffinity Capture-MS\\tSMURF2\\r\\nAffinity Capture-MS\\tSNW1\\r\\nAffinity Capture-MS\\tSQRDL\\r\\nAffinity Capture-MS\\tSUZ12\\r\\nAffinity Capture-MS\\tTAF1\\r\\nAffinity Capture-MS\\tTAF2\\r\\nAffinity Capture-MS\\tTCP1\\r\\nAffinity Capture-MS\\tTGFB1\\r\\nAffinity Capture-MS\\tTMEM192\\r\\nAffinity Capture-MS\\tTRIM33\\r\\nAffinity Capture-MS\\tTRIM67\\r\\nAffinity Capture-MS\\tTRIP4\\r\\nAffinity Capture-MS\\tU2AF2\\r\\nAffinity Capture-MS\\tUGT1A10\\r\\nAffinity Capture-MS\\tUSP33\\r\\nAffinity Capture-MS\\tUSP7\\r\\nAffinity Capture-MS\\tVAV2\\r\\nAffinity Capture-MS\\tWWP2\\r\\nAffinity Capture-MS\\tYTHDF2\\r\\nAffinity Capture-MS\\tYY1\\r\\nAffinity Capture-MS\\tZFP69B\\r\\nAffinity Capture-MS\\tZFYVE9\\r\\nAffinity Capture-MS\\tZRANB1\\r\\nAffinity Capture-RNA\\tDDX58\\r\\nAffinity Capture-RNA\\tTRIM25\\r\\nAffinity Capture-Western\\tACTB\\r\\nAffinity Capture-Western\\tACVR1B\\r\\nAffinity Capture-Western\\tAKT1\\r\\nAffinity Capture-Western\\tANAPC10\\r\\nAffinity Capture-Western\\tAR\\r\\nAffinity Capture-Western\\tATF2\\r\\nAffinity Capture-Western\\tATF3\\r\\nAffinity Capture-Western\\tBACH1\\r\\nAffinity Capture-Western\\tBRCA1\\r\\nAffinity Capture-Western\\tBRCA2\\r\\nAffinity Capture-Western\\tBTRC\\r\\nAffinity Capture-Western\\tCBL\\r\\nAffinity Capture-Western\\tCDC16\\r\\nAffinity Capture-Western\\tCDC25A\\r\\nAffinity Capture-Western\\tCDC27\\r\\nAffinity Capture-Western\\tCDKN1A\\r\\nAffinity Capture-Western\\tCEBPD\\r\\nAffinity Capture-Western\\tCHRD\\r\\nAffinity Capture-Western\\tCHUK\\r\\nAffinity Capture-Western\\tCITED2\\r\\nAffinity Capture-Western\\tCREBBP\\r\\nAffinity Capture-Western\\tCSNK1D\\r\\nAffinity Capture-Western\\tCSNK1G2\\r\\nAffinity Capture-Western\\tCTCF\\r\\nAffinity Capture-Western\\tCTNNB1\\r\\nAffinity Capture-Western\\tCUL1\\r\\nAffinity Capture-Western\\tDAB2\\r\\nAffinity Capture-Western\\tDACH1\\r\\nAffinity Capture-Western\\tDEDD\\r\\nAffinity Capture-Western\\tDOCK9\\r\\nAffinity Capture-Western\\tE2F4\\r\\nAffinity Capture-Western\\tEID2\\r\\nAffinity Capture-Western\\tELAC2\\r\\nAffinity Capture-Western\\tEP300\\r\\nAffinity Capture-Western\\tERBB2IP\\r\\nAffinity Capture-Western\\tESR1\\r\\nAffinity Capture-Western\\tEZH2\\r\\nAffinity Capture-Western\\tFHL1\\r\\nAffinity Capture-Western\\tFHL2\\r\\nAffinity Capture-Western\\tFHL3\\r\\nAffinity Capture-Western\\tFOS\\r\\nAffinity Capture-Western\\tFOXH1\\r\\nAffinity Capture-Western\\tFOXL2\\r\\nAffinity Capture-Western\\tFOXM1\\r\\nAffinity Capture-Western\\tFOXO1\\r\\nAffinity Capture-Western\\tFOXO3\\r\\nAffinity Capture-Western\\tFOXO4\\r\\nAffinity Capture-Western\\tGRIP1\\r\\nAffinity Capture-Western\\tGSK3B\\r\\nAffinity Capture-Western\\tHDAC4\\r\\nAffinity Capture-Western\\tHDAC5\\r\\nAffinity Capture-Western\\tHGS\\r\\nAffinity Capture-Western\\tHIF1A\\r\\nAffinity Capture-Western\\tHNF4A\\r\\nAffinity Capture-Western\\tHYAL2\\r\\nAffinity Capture-Western\\tID1\\r\\nAffinity Capture-Western\\tIRF7\\r\\nAffinity Capture-Western\\tJUN\\r\\nAffinity Capture-Western\\tKAT2A\\r\\nAffinity Capture-Western\\tKAT2B\\r\\nAffinity Capture-Western\\tKAT6A\\r\\nAffinity Capture-Western\\tKDM5C\\r\\nAffinity Capture-Western\\tKDM6B\\r\\nAffinity Capture-Western\\tKLF5\\r\\nAffinity Capture-Western\\tKPNB1\\r\\nAffinity Capture-Western\\tLEF1\\r\\nAffinity Capture-Western\\tMAFK\\r\\nAffinity Capture-Western\\tMECOM\\r\\nAffinity Capture-Western\\tMED15\\r\\nAffinity Capture-Western\\tMED24\\r\\nAffinity Capture-Western\\tMED6\\r\\nAffinity Capture-Western\\tMEN1\\r\\nAffinity Capture-Western\\tMETTL14\\r\\nAffinity Capture-Western\\tMETTL3\\r\\nAffinity Capture-Western\\tMKL1\\r\\nAffinity Capture-Western\\tMYC\\r\\nAffinity Capture-Western\\tMYD88\\r\\nAffinity Capture-Western\\tMYOCD\\r\\nAffinity Capture-Western\\tNCOA1\\r\\nAffinity Capture-Western\\tNEDD4\\r\\nAffinity Capture-Western\\tNEDD4L\\r\\nAffinity Capture-Western\\tNEDD9\\r\\nAffinity Capture-Western\\tNFIC\\r\\nAffinity Capture-Western\\tNFYC\\r\\nAffinity Capture-Western\\tNOTCH1\\r\\nAffinity Capture-Western\\tNOTCH4\\r\\nAffinity Capture-Western\\tNR3C1\\r\\nAffinity Capture-Western\\tNR4A1\\r\\nAffinity Capture-Western\\tNUP214\\r\\nAffinity Capture-Western\\tOTUB1\\r\\nAffinity Capture-Western\\tOTUD1\\r\\nAffinity Capture-Western\\tOVOL2\\r\\nAffinity Capture-Western\\tPAX6\\r\\nAffinity Capture-Western\\tPCK2\\r\\nAffinity Capture-Western\\tPDLIM5\\r\\nAffinity Capture-Western\\tPIAS3\\r\\nAffinity Capture-Western\\tPIAS4\\r\\nAffinity Capture-Western\\tPIN1\\r\\nAffinity Capture-Western\\tPITX1\\r\\nAffinity Capture-Western\\tPITX2\\r\\nAffinity Capture-Western\\tPML\\r\\nAffinity Capture-Western\\tPPARG\\r\\nAffinity Capture-Western\\tPPP1R12C\\r\\nAffinity Capture-Western\\tPRDM16\\r\\nAffinity Capture-Western\\tPRTN3\\r\\nAffinity Capture-Western\\tRARA\\r\\nAffinity Capture-Western\\tRBBP5\\r\\nAffinity Capture-Western\\tRBL1\\r\\nAffinity Capture-Western\\tRBX1\\r\\nAffinity Capture-Western\\tRELB\\r\\nAffinity Capture-Western\\tRGCC\\r\\nAffinity Capture-Western\\tRNF111\\r\\nAffinity Capture-Western\\tRNF31\\r\\nAffinity Capture-Western\\tRUNX1\\r\\nAffinity Capture-Western\\tRUNX2\\r\\nAffinity Capture-Western\\tRUNX3\\r\\nAffinity Capture-Western\\tS100A4\\r\\nAffinity Capture-Western\\tSETD2\\r\\nAffinity Capture-Western\\tSH2D2A\\r\\nAffinity Capture-Western\\tSKI\\r\\nAffinity Capture-Western\\tSKIL\\r\\nAffinity Capture-Western\\tSMAD2\\r\\nAffinity Capture-Western\\tSMAD3\\r\\nAffinity Capture-Western\\tSMAD4\\r\\nAffinity Capture-Western\\tSMAD7\\r\\nAffinity Capture-Western\\tSMARCA4\\r\\nAffinity Capture-Western\\tSMARCC2\\r\\nAffinity Capture-Western\\tSMURF1\\r\\nAffinity Capture-Western\\tSMURF2\\r\\nAffinity Capture-Western\\tSOX9\\r\\nAffinity Capture-Western\\tSP1\\r\\nAffinity Capture-Western\\tSPTBN1\\r\\nAffinity Capture-Western\\tSQSTM1\\r\\nAffinity Capture-Western\\tSREBF2\\r\\nAffinity Capture-Western\\tSRY\\r\\nAffinity Capture-Western\\tSTRAP\\r\\nAffinity Capture-Western\\tSTUB1\\r\\nAffinity Capture-Western\\tSUV39H1\\r\\nAffinity Capture-Western\\tTCF12\\r\\nAffinity Capture-Western\\tTGFB1I1\\r\\nAffinity Capture-Western\\tTGFBR1\\r\\nAffinity Capture-Western\\tTGFBR2\\r\\nAffinity Capture-Western\\tTGIF1\\r\\nAffinity Capture-Western\\tTGIF2\\r\\nAffinity Capture-Western\\tTOB1\\r\\nAffinity Capture-Western\\tTP53\\r\\nAffinity Capture-Western\\tTRIB3\\r\\nAffinity Capture-Western\\tTRIM24\\r\\nAffinity Capture-Western\\tTRIM33\\r\\nAffinity Capture-Western\\tTRIM62\\r\\nAffinity Capture-Western\\tTSC2\\r\\nAffinity Capture-Western\\tTSC22D4\\r\\nAffinity Capture-Western\\tUCHL1\\r\\nAffinity Capture-Western\\tUCHL5\\r\\nAffinity Capture-Western\\tUSP15\\r\\nAffinity Capture-Western\\tUSP2\\r\\nAffinity Capture-Western\\tUSP7\\r\\nAffinity Capture-Western\\tUSP9X\\r\\nAffinity Capture-Western\\tWWOX\\r\\nAffinity Capture-Western\\tWWP1\\r\\nAffinity Capture-Western\\tWWP2\\r\\nAffinity Capture-Western\\tYAP1\\r\\nAffinity Capture-Western\\tZC3H12A\\r\\nAffinity Capture-Western\\tZEB1\\r\\nAffinity Capture-Western\\tZEB2\\r\\nAffinity Capture-Western\\tZFYVE9\\r\\nAffinity Capture-Western\\tZMIZ1\\r\\nBiochemical Activity\\tCDK2\\r\\nBiochemical Activity\\tCDK4\\r\\nBiochemical Activity\\tCDK8\\r\\nBiochemical Activity\\tCDK9\\r\\nBiochemical Activity\\tCSNK1D\\r\\nBiochemical Activity\\tCSNK1G2\\r\\nBiochemical Activity\\tMAPK1\\r\\nBiochemical Activity\\tNEDD4\\r\\nBiochemical Activity\\tNEDD4L\\r\\nBiochemical Activity\\tOTUB1\\r\\nBiochemical Activity\\tTGFBR1\\r\\nBiochemical Activity\\tUSP15\\r\\nBiochemical Activity\\tUSP7\\r\\nBiochemical Activity\\tWWP2\\r\\nCo-crystal Structure\\tSMAD3\\r\\nCo-crystal Structure\\tSMAD4\\r\\nCo-crystal Structure\\tZFYVE9\\r\\nCo-fractionation\\tALKBH2\\r\\nCo-fractionation\\tANAPC10\\r\\nCo-fractionation\\tAPP\\r\\nCo-fractionation\\tARID1B\\r\\nCo-fractionation\\tCDH1\\r\\nCo-fractionation\\tCREBBP\\r\\nCo-fractionation\\tCTCF\\r\\nCo-fractionation\\tCTNNB1\\r\\nCo-fractionation\\tCUL1\\r\\nCo-fractionation\\tDDR1\\r\\nCo-fractionation\\tFOXO3\\r\\nCo-fractionation\\tHDAC1\\r\\nCo-fractionation\\tHMGA2\\r\\nCo-fractionation\\tIGF1R\\r\\nCo-fractionation\\tITGB1\\r\\nCo-fractionation\\tJUND\\r\\nCo-fractionation\\tMTA2\\r\\nCo-fractionation\\tNAA15\\r\\nCo-fractionation\\tNT5DC3\\r\\nCo-fractionation\\tPARP1\\r\\nCo-fractionation\\tPRKDC\\r\\nCo-fractionation\\tRBM14\\r\\nCo-fractionation\\tRBX1\\r\\nCo-fractionation\\tRELA\\r\\nCo-fractionation\\tRIPK1\\r\\nCo-fractionation\\tRNMT\\r\\nCo-fractionation\\tSIN3A\\r\\nCo-fractionation\\tSKP1\\r\\nCo-fractionation\\tSMAD2\\r\\nCo-fractionation\\tSMARCA4\\r\\nCo-fractionation\\tSMARCC1\\r\\nCo-fractionation\\tSMARCC2\\r\\nCo-fractionation\\tSNF8\\r\\nCo-fractionation\\tSP1\\r\\nCo-fractionation\\tSUB1\\r\\nCo-fractionation\\tTRIM33\\r\\nCo-fractionation\\tXRCC5\\r\\nCo-fractionation\\tXRCC6\\r\\nCo-fractionation\\tZFHX3\\r\\nCo-fractionation\\tZFYVE9\\r\\nCo-localization\\tAKT1\\r\\nCo-localization\\tBMP7\\r\\nCo-localization\\tCAMK2G\\r\\nCo-localization\\tCDK2\\r\\nCo-localization\\tCDK4\\r\\nCo-localization\\tEPAS1\\r\\nCo-localization\\tETS1\\r\\nCo-localization\\tFOXO3\\r\\nCo-localization\\tHIF1A\\r\\nCo-localization\\tIRF7\\r\\nCo-localization\\tMAP3K7\\r\\nCo-localization\\tMAPK8\\r\\nCo-localization\\tMAX\\r\\nCo-localization\\tTP53\\r\\nCo-localization\\tTRIM62\\r\\nCross-Linking-MS (XL-MS)\\tRPL10A\\r\\nFRET\\tSMAD4\\r\\nFRET\\tSTUB1\\r\\nPCA\\tSMAD4\\r\\nPCA\\tSMAD7\\r\\nPhenotypic Enhancement\\tHIF1A\\r\\nPhenotypic Enhancement\\tSMAD2\\r\\nPhenotypic Enhancement\\tSNW1\\r\\nPhenotypic Suppression\\tSMAD7\\r\\nPhenotypic Suppression\\tSTRAP\\r\\nPositive Genetic\\tJAK1\\r\\nProtein-RNA\\tLINC00941\\r\\nProtein-peptide\\tCREBBP\\r\\nProtein-peptide\\tFOXH1\\r\\nProtein-peptide\\tITCH\\r\\nProtein-peptide\\tLEF1\\r\\nProtein-peptide\\tNEDD4\\r\\nProtein-peptide\\tPIN1\\r\\nProximity Label-MS\\tNFIA\\r\\nReconstituted Complex\\tANAPC10\\r\\nReconstituted Complex\\tAPP\\r\\nReconstituted Complex\\tAR\\r\\nReconstituted Complex\\tATF2\\r\\nReconstituted Complex\\tATF3\\r\\nReconstituted Complex\\tBPTF\\r\\nReconstituted Complex\\tBRCA1\\r\\nReconstituted Complex\\tBRCA2\\r\\nReconstituted Complex\\tCEBPA\\r\\nReconstituted Complex\\tCEBPB\\r\\nReconstituted Complex\\tCEBPD\\r\\nReconstituted Complex\\tCITED2\\r\\nReconstituted Complex\\tCREBBP\\r\\nReconstituted Complex\\tCTCF\\r\\nReconstituted Complex\\tDAB2\\r\\nReconstituted Complex\\tDDX5\\r\\nReconstituted Complex\\tDEDD\\r\\nReconstituted Complex\\tDNMT3L\\r\\nReconstituted Complex\\tDVL1\\r\\nReconstituted Complex\\tE2F4\\r\\nReconstituted Complex\\tEID2\\r\\nReconstituted Complex\\tEIF4B\\r\\nReconstituted Complex\\tEP300\\r\\nReconstituted Complex\\tERBB2IP\\r\\nReconstituted Complex\\tFHL1\\r\\nReconstituted Complex\\tFHL2\\r\\nReconstituted Complex\\tFHL3\\r\\nReconstituted Complex\\tFOS\\r\\nReconstituted Complex\\tFOXH1\\r\\nReconstituted Complex\\tFOXM1\\r\\nReconstituted Complex\\tGSK3B\\r\\nReconstituted Complex\\tHDAC1\\r\\nReconstituted Complex\\tHDAC4\\r\\nReconstituted Complex\\tHDAC5\\r\\nReconstituted Complex\\tHIF1A\\r\\nReconstituted Complex\\tHIPK2\\r\\nReconstituted Complex\\tHNF4A\\r\\nReconstituted Complex\\tHYAL2\\r\\nReconstituted Complex\\tIRF7\\r\\nReconstituted Complex\\tITCH\\r\\nReconstituted Complex\\tJUN\\r\\nReconstituted Complex\\tJUNB\\r\\nReconstituted Complex\\tJUND\\r\\nReconstituted Complex\\tKAT2B\\r\\nReconstituted Complex\\tKAT6A\\r\\nReconstituted Complex\\tKPNB1\\r\\nReconstituted Complex\\tLCK\\r\\nReconstituted Complex\\tLEF1\\r\\nReconstituted Complex\\tLEMD3\\r\\nReconstituted Complex\\tMAX\\r\\nReconstituted Complex\\tMDM4\\r\\nReconstituted Complex\\tMECOM\\r\\nReconstituted Complex\\tMYC\\r\\nReconstituted Complex\\tMYOCD\\r\\nReconstituted Complex\\tNEDD4\\r\\nReconstituted Complex\\tNEDD4L\\r\\nReconstituted Complex\\tNEDD9\\r\\nReconstituted Complex\\tNFIA\\r\\nReconstituted Complex\\tNOTCH1\\r\\nReconstituted Complex\\tNR3C1\\r\\nReconstituted Complex\\tNUP153\\r\\nReconstituted Complex\\tNUP214\\r\\nReconstituted Complex\\tPARD3\\r\\nReconstituted Complex\\tPIAS2\\r\\nReconstituted Complex\\tPIAS3\\r\\nReconstituted Complex\\tPIAS4\\r\\nReconstituted Complex\\tPIK3CA\\r\\nReconstituted Complex\\tPIN1\\r\\nReconstituted Complex\\tRBL1\\r\\nReconstituted Complex\\tRUNX2\\r\\nReconstituted Complex\\tS100A4\\r\\nReconstituted Complex\\tSH2D2A\\r\\nReconstituted Complex\\tSIN3A\\r\\nReconstituted Complex\\tSKI\\r\\nReconstituted Complex\\tSKIL\\r\\nReconstituted Complex\\tSMAD3\\r\\nReconstituted Complex\\tSMAD4\\r\\nReconstituted Complex\\tSMURF2\\r\\nReconstituted Complex\\tSNW1\\r\\nReconstituted Complex\\tSP1\\r\\nReconstituted Complex\\tSTUB1\\r\\nReconstituted Complex\\tTFE3\\r\\nReconstituted Complex\\tTGFB1I1\\r\\nReconstituted Complex\\tTGFBR1\\r\\nReconstituted Complex\\tTGIF1\\r\\nReconstituted Complex\\tTP53\\r\\nReconstituted Complex\\tTRIM24\\r\\nReconstituted Complex\\tTRIM33\\r\\nReconstituted Complex\\tTRIM62\\r\\nReconstituted Complex\\tTSC2\\r\\nReconstituted Complex\\tUCHL5\\r\\nReconstituted Complex\\tUSP15\\r\\nReconstituted Complex\\tVDR\\r\\nReconstituted Complex\\tWWOX\\r\\nReconstituted Complex\\tXPO6\\r\\nReconstituted Complex\\tYY1\\r\\nReconstituted Complex\\tZFYVE9\\r\\nReconstituted Complex\\tZMIZ1\\r\\nTwo-hybrid\\tAATF\\r\\nTwo-hybrid\\tAES\\r\\nTwo-hybrid\\tANK3\\r\\nTwo-hybrid\\tAPMAP\\r\\nTwo-hybrid\\tAPOB\\r\\nTwo-hybrid\\tAR\\r\\nTwo-hybrid\\tATF2\\r\\nTwo-hybrid\\tBLZF1\\r\\nTwo-hybrid\\tC10ORF54\\r\\nTwo-hybrid\\tC14ORF105\\r\\nTwo-hybrid\\tCCDC33\\r\\nTwo-hybrid\\tCDC25A\\r\\nTwo-hybrid\\tCFDP1\\r\\nTwo-hybrid\\tCFH\\r\\nTwo-hybrid\\tCFLAR\\r\\nTwo-hybrid\\tCHRD\\r\\nTwo-hybrid\\tCORO1A\\r\\nTwo-hybrid\\tCPSF7\\r\\nTwo-hybrid\\tCPTP\\r\\nTwo-hybrid\\tCREBBP\\r\\nTwo-hybrid\\tCRX\\r\\nTwo-hybrid\\tCSH2\\r\\nTwo-hybrid\\tCXXC5\\r\\nTwo-hybrid\\tCYP11A1\\r\\nTwo-hybrid\\tDEDD\\r\\nTwo-hybrid\\tDNAJB4\\r\\nTwo-hybrid\\tDNAJB5\\r\\nTwo-hybrid\\tEBI3\\r\\nTwo-hybrid\\tEP300\\r\\nTwo-hybrid\\tEPAS1\\r\\nTwo-hybrid\\tFAM90A1\\r\\nTwo-hybrid\\tFBLN1\\r\\nTwo-hybrid\\tFLI1\\r\\nTwo-hybrid\\tFLNA\\r\\nTwo-hybrid\\tFOS\\r\\nTwo-hybrid\\tFOXH1\\r\\nTwo-hybrid\\tGGA1\\r\\nTwo-hybrid\\tGIT2\\r\\nTwo-hybrid\\tGMEB1\\r\\nTwo-hybrid\\tHDAC1\\r\\nTwo-hybrid\\tHEY1\\r\\nTwo-hybrid\\tHEYL\\r\\nTwo-hybrid\\tHIF1A\\r\\nTwo-hybrid\\tHIVEP1\\r\\nTwo-hybrid\\tHNRNPK\\r\\nTwo-hybrid\\tHOXC11\\r\\nTwo-hybrid\\tHP\\r\\nTwo-hybrid\\tISL1\\r\\nTwo-hybrid\\tJUN\\r\\nTwo-hybrid\\tJUNB\\r\\nTwo-hybrid\\tKANSL1\\r\\nTwo-hybrid\\tKDM2A\\r\\nTwo-hybrid\\tKMT2B\\r\\nTwo-hybrid\\tLBP\\r\\nTwo-hybrid\\tMCM3AP\\r\\nTwo-hybrid\\tMEOX2\\r\\nTwo-hybrid\\tMTF2\\r\\nTwo-hybrid\\tMYC\\r\\nTwo-hybrid\\tMYD88\\r\\nTwo-hybrid\\tNCOA6\\r\\nTwo-hybrid\\tNEDD4\\r\\nTwo-hybrid\\tNEDD9\\r\\nTwo-hybrid\\tNR4A1\\r\\nTwo-hybrid\\tPAPPA\\r\\nTwo-hybrid\\tPARP4\\r\\nTwo-hybrid\\tPCDH1\\r\\nTwo-hybrid\\tPCK2\\r\\nTwo-hybrid\\tPHC2\\r\\nTwo-hybrid\\tPIAS4\\r\\nTwo-hybrid\\tPIN1\\r\\nTwo-hybrid\\tPLAG1\\r\\nTwo-hybrid\\tPLAGL1\\r\\nTwo-hybrid\\tPLG\\r\\nTwo-hybrid\\tPPP1R12C\\r\\nTwo-hybrid\\tPPP2R1A\\r\\nTwo-hybrid\\tPRDM4\\r\\nTwo-hybrid\\tPROX1\\r\\nTwo-hybrid\\tPSMB1\\r\\nTwo-hybrid\\tPSMD11\\r\\nTwo-hybrid\\tRANBP9\\r\\nTwo-hybrid\\tRBPMS\\r\\nTwo-hybrid\\tRBX1\\r\\nTwo-hybrid\\tRCVRN\\r\\nTwo-hybrid\\tRELA\\r\\nTwo-hybrid\\tRIOK2\\r\\nTwo-hybrid\\tRNF31\\r\\nTwo-hybrid\\tRPA1\\r\\nTwo-hybrid\\tRPLP0\\r\\nTwo-hybrid\\tSAP130\\r\\nTwo-hybrid\\tSBK3\\r\\nTwo-hybrid\\tSERTAD1\\r\\nTwo-hybrid\\tSETD2\\r\\nTwo-hybrid\\tSKIL\\r\\nTwo-hybrid\\tSMAD1\\r\\nTwo-hybrid\\tSMAD2\\r\\nTwo-hybrid\\tSMAD3\\r\\nTwo-hybrid\\tSMAD4\\r\\nTwo-hybrid\\tSMURF1\\r\\nTwo-hybrid\\tSMURF2\\r\\nTwo-hybrid\\tSNRNP70\\r\\nTwo-hybrid\\tSNW1\\r\\nTwo-hybrid\\tSP1\\r\\nTwo-hybrid\\tSQSTM1\\r\\nTwo-hybrid\\tSS18L1\\r\\nTwo-hybrid\\tST6GALNAC2\\r\\nTwo-hybrid\\tSVEP1\\r\\nTwo-hybrid\\tTANK\\r\\nTwo-hybrid\\tTDP2\\r\\nTwo-hybrid\\tTEKT4\\r\\nTwo-hybrid\\tTF\\r\\nTwo-hybrid\\tTGM2\\r\\nTwo-hybrid\\tTLR4\\r\\nTwo-hybrid\\tTMED1\\r\\nTwo-hybrid\\tTSC22D4\\r\\nTwo-hybrid\\tUBQLN4\\r\\nTwo-hybrid\\tUSP7\\r\\nTwo-hybrid\\tVDR\\r\\nTwo-hybrid\\tWWP1\\r\\nTwo-hybrid\\tWWP2\\r\\nTwo-hybrid\\tXRCC6\\r\\nTwo-hybrid\\tZBTB16\\r\\nTwo-hybrid\\tZBTB3\\r\\nTwo-hybrid\\tZC3H12A\\r\\nTwo-hybrid\\tZCCHC14\\r\\nTwo-hybrid\\tZEB2\\r\\nTwo-hybrid\\tZFYVE9\\r\\nTwo-hybrid\\tZMYND11\\r\\nTwo-hybrid\\tZNF329\\r\\nTwo-hybrid\\tZNF774\\r\\nTwo-hybrid\\tZNF83\\r\\n\"],[\"20251224-191245_ui/genes/SMAD3/gene.json\",\"{\\n \\\"identifiers\\\": {\\n \\\"symbol\\\": \\\"SMAD3\\\",\\n \\\"entrez_id\\\": \\\"4088\\\",\\n \\\"uniprot_id\\\": \\\"P84022\\\",\\n \\\"ensembl_id\\\": null,\\n \\\"aliases\\\": [],\\n \\\"gene_type\\\": null\\n },\\n \\\"location\\\": null,\\n \\\"annotations\\\": {\\n \\\"go_annotations\\\": [\\n \\\"C:SMAD protein complex\\\",\\n \\\"C:chromatin\\\",\\n \\\"C:ciliary basal body\\\",\\n \\\"C:cytoplasm\\\",\\n \\\"C:cytosol\\\",\\n \\\"C:heteromeric SMAD protein complex\\\",\\n \\\"C:intracellular membrane-bounded organelle\\\",\\n \\\"C:nuclear inner membrane\\\",\\n \\\"C:nucleoplasm\\\",\\n \\\"C:nucleus\\\",\\n \\\"C:plasma membrane\\\",\\n \\\"C:receptor complex\\\",\\n \\\"C:transcription regulator complex\\\",\\n \\\"F:DEAD/H-box RNA helicase binding\\\",\\n \\\"F:DNA binding\\\",\\n \\\"F:DNA-binding transcription activator activity, RNA polymerase II-specific\\\",\\n \\\"F:DNA-binding transcription factor activity\\\",\\n \\\"F:DNA-binding transcription factor activity, RNA polymerase II-specific\\\",\\n \\\"F:DNA-binding transcription factor binding\\\",\\n \\\"F:DNA-binding transcription repressor activity\\\",\\n \\\"F:I-SMAD binding\\\",\\n \\\"F:R-SMAD binding\\\",\\n \\\"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding\\\",\\n \\\"F:RNA polymerase II-specific DNA-binding transcription factor binding\\\",\\n \\\"F:bHLH transcription factor binding\\\",\\n \\\"F:beta-catenin binding\\\",\\n \\\"F:chromatin DNA binding\\\",\\n \\\"F:cis-regulatory region sequence-specific DNA binding\\\",\\n \\\"F:co-SMAD binding\\\",\\n \\\"F:collagen binding\\\",\\n \\\"F:identical protein binding\\\",\\n \\\"F:nuclear glucocorticoid receptor binding\\\",\\n \\\"F:nuclear mineralocorticoid receptor binding\\\",\\n \\\"F:nuclear receptor binding\\\",\\n \\\"F:phosphatase binding\\\",\\n \\\"F:promoter-specific chromatin binding\\\",\\n \\\"F:protein homodimerization activity\\\",\\n \\\"F:protein kinase binding\\\",\\n \\\"F:sequence-specific DNA binding\\\",\\n \\\"F:sterol response element binding\\\",\\n \\\"F:transcription cis-regulatory region binding\\\",\\n \\\"F:transcription coactivator binding\\\",\\n \\\"F:transcription corepressor binding\\\",\\n \\\"F:transforming growth factor beta receptor binding\\\",\\n \\\"F:ubiquitin binding\\\",\\n \\\"F:ubiquitin protein ligase binding\\\",\\n \\\"F:zinc ion binding\\\",\\n \\\"P:JNK cascade\\\",\\n \\\"P:SMAD protein signal transduction\\\",\\n \\\"P:T cell activation\\\",\\n \\\"P:activin receptor signaling pathway\\\",\\n \\\"P:adrenal gland development\\\",\\n \\\"P:anatomical structure morphogenesis\\\",\\n \\\"P:apoptotic signaling pathway\\\",\\n \\\"P:cell differentiation\\\",\\n \\\"P:cell population proliferation\\\",\\n \\\"P:cell-cell junction organization\\\",\\n \\\"P:cellular response to glucose stimulus\\\",\\n \\\"P:cellular response to transforming growth factor beta stimulus\\\",\\n \\\"P:cellular response to virus\\\",\\n \\\"P:developmental growth\\\",\\n \\\"P:embryonic cranial skeleton morphogenesis\\\",\\n \\\"P:embryonic foregut morphogenesis\\\",\\n \\\"P:embryonic pattern specification\\\",\\n \\\"P:endoderm development\\\",\\n \\\"P:extrinsic apoptotic signaling pathway\\\",\\n \\\"P:heart looping\\\",\\n \\\"P:immune response\\\",\\n \\\"P:immune system development\\\",\\n \\\"P:in utero embryonic development\\\",\\n \\\"P:lens fiber cell differentiation\\\",\\n \\\"P:liver development\\\",\\n \\\"P:mesoderm formation\\\",\\n \\\"P:negative regulation of apoptotic process\\\",\\n \\\"P:negative regulation of cardiac muscle hypertrophy in response to stress\\\",\\n \\\"P:negative regulation of cell differentiation\\\",\\n \\\"P:negative regulation of cell growth\\\",\\n \\\"P:negative regulation of cell population proliferation\\\",\\n \\\"P:negative regulation of cytosolic calcium ion concentration\\\",\\n \\\"P:negative regulation of fat cell differentiation\\\",\\n \\\"P:negative regulation of gene expression\\\",\\n \\\"P:negative regulation of inflammatory response\\\",\\n \\\"P:negative regulation of lung blood pressure\\\",\\n \\\"P:negative regulation of miRNA transcription\\\",\\n \\\"P:negative regulation of ossification\\\",\\n \\\"P:negative regulation of osteoblast differentiation\\\",\\n \\\"P:negative regulation of osteoblast proliferation\\\",\\n \\\"P:negative regulation of protein catabolic process\\\",\\n \\\"P:negative regulation of transcription by RNA polymerase II\\\",\\n \\\"P:negative regulation of wound healing\\\",\\n \\\"P:nodal signaling pathway\\\",\\n \\\"P:osteoblast development\\\",\\n \\\"P:paraxial mesoderm morphogenesis\\\",\\n \\\"P:pericardium development\\\",\\n \\\"P:positive regulation of DNA-templated transcription\\\",\\n \\\"P:positive regulation of SMAD protein signal transduction\\\",\\n \\\"P:positive regulation of bone mineralization\\\",\\n \\\"P:positive regulation of canonical Wnt signaling pathway\\\",\\n \\\"P:positive regulation of cell migration\\\",\\n \\\"P:positive regulation of chondrocyte differentiation\\\",\\n \\\"P:positive regulation of epithelial to mesenchymal transition\\\",\\n \\\"P:positive regulation of extracellular matrix assembly\\\",\\n \\\"P:positive regulation of focal adhesion assembly\\\",\\n \\\"P:positive regulation of gene expression\\\",\\n \\\"P:positive regulation of interleukin-1 beta production\\\",\\n \\\"P:positive regulation of miRNA transcription\\\",\\n \\\"P:positive regulation of nitric oxide biosynthetic process\\\",\\n \\\"P:positive regulation of positive chemotaxis\\\",\\n \\\"P:positive regulation of protein import into nucleus\\\",\\n \\\"P:positive regulation of stress fiber assembly\\\",\\n \\\"P:positive regulation of transcription by RNA polymerase II\\\",\\n \\\"P:positive regulation of transforming growth factor beta3 production\\\",\\n \\\"P:primary miRNA processing\\\",\\n \\\"P:protein stabilization\\\",\\n \\\"P:regulation of DNA-templated transcription\\\",\\n \\\"P:regulation of epithelial cell proliferation\\\",\\n \\\"P:regulation of immune response\\\",\\n \\\"P:regulation of miRNA transcription\\\",\\n \\\"P:regulation of mitochondrial membrane potential\\\",\\n \\\"P:regulation of striated muscle tissue development\\\",\\n \\\"P:regulation of transcription by RNA polymerase II\\\",\\n \\\"P:regulation of transforming growth factor beta receptor signaling pathway\\\",\\n \\\"P:regulation of transforming growth factor beta2 production\\\",\\n \\\"P:release of cytochrome c from mitochondria\\\",\\n \\\"P:response to angiotensin\\\",\\n \\\"P:response to hypoxia\\\",\\n \\\"P:signal transduction involved in regulation of gene expression\\\",\\n \\\"P:somitogenesis\\\",\\n \\\"P:thyroid gland development\\\",\\n \\\"P:transdifferentiation\\\",\\n \\\"P:transforming growth factor beta receptor signaling pathway\\\",\\n \\\"P:trophoblast cell migration\\\",\\n \\\"P:ureteric bud development\\\",\\n \\\"P:wound healing\\\"\\n ],\\n \\\"functions\\\": [\\n \\\"Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator\\\"\\n ],\\n \\\"diseases\\\": [\\n \\\"Colorectal cancer\\\",\\n \\\"Loeys-Dietz syndrome 3\\\"\\n ],\\n \\\"pathways\\\": [\\n \\\"Cytokine Signaling in Immune system\\\",\\n \\\"Interleukin-1 family signaling\\\",\\n \\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\",\\n \\\"Developmental Biology\\\",\\n \\\"Viral Infection Pathways\\\",\\n \\\"Signaling by TGFBR3\\\",\\n \\\"Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer\\\",\\n \\\"Signaling by Interleukins\\\",\\n \\\"Deubiquitination\\\",\\n \\\"Signaling by NOTCH\\\",\\n \\\"TGF-beta receptor signaling activates SMADs\\\",\\n \\\"Signaling by TGFB family members\\\",\\n \\\"Loss of Function of TGFBR1 in Cancer\\\",\\n \\\"RUNX3 regulates CDKN1A transcription\\\",\\n \\\"SARS-CoV-1 targets host intracellular signalling and regulatory pathways\\\",\\n \\\"Signaling by TGF-beta Receptor Complex\\\",\\n \\\"TGFBR1 KD Mutants in Cancer\\\",\\n \\\"Post-translational protein modification\\\",\\n \\\"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes\\\",\\n \\\"TGFBR3 expression\\\",\\n \\\"Disease\\\",\\n \\\"Generic Transcription Pathway\\\",\\n \\\"Metabolism of proteins\\\",\\n \\\"Gene expression (Transcription)\\\",\\n \\\"Signal Transduction\\\",\\n \\\"SARS-CoV-1-host interactions\\\",\\n \\\"FOXO-mediated transcription\\\",\\n \\\"Infectious disease\\\",\\n \\\"Gastrulation\\\",\\n \\\"RNA Polymerase II Transcription\\\",\\n \\\"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription\\\",\\n \\\"NOTCH4 Intracellular Domain Regulates Transcription\\\",\\n \\\"FOXO-mediated transcription of cell cycle genes\\\",\\n \\\"Loss of Function of SMAD2/3 in Cancer\\\",\\n \\\"SMAD4 MH2 Domain Mutants in Cancer\\\",\\n \\\"Diseases of signal transduction by growth factor receptors and second messengers\\\",\\n \\\"SARS-CoV Infections\\\",\\n \\\"Formation of axial mesoderm\\\",\\n \\\"SARS-CoV-1 Infection\\\",\\n \\\"Germ layer formation at gastrulation\\\",\\n \\\"Signaling by NOTCH4\\\",\\n \\\"Downregulation of TGF-beta receptor signaling\\\",\\n \\\"Interleukin-37 signaling\\\",\\n \\\"Formation of definitive endoderm\\\",\\n \\\"RUNX3 regulates BCL2L11 (BIM) transcription\\\",\\n \\\"Ub-specific processing proteases\\\",\\n \\\"Loss of Function of SMAD4 in Cancer\\\",\\n \\\"Downregulation of SMAD2/3:SMAD4 transcriptional activity\\\",\\n \\\"Immune System\\\",\\n \\\"SMAD2/3 MH2 Domain Mutants in Cancer\\\",\\n \\\"Transcriptional regulation by RUNX3\\\",\\n \\\"Signaling by Activin\\\",\\n \\\"Signaling by TGF-beta Receptor Complex in Cancer\\\",\\n \\\"Signaling by NODAL\\\"\\n ],\\n \\\"cell_localizations\\\": [],\\n \\\"predicted_go\\\": [],\\n \\\"predicted_disease\\\": []\\n },\\n \\\"interactions\\\": {\\n \\\"human_interactions\\\": {\\n \\\"Affinity Capture-Luminescence\\\": [\\n 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\\\"DAZARD_RESPONSE_TO_UV_NHEK_DN\\\",\\n \\\"WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY\\\",\\n \\\"OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN\\\",\\n \\\"RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN\\\",\\n \\\"REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM\\\",\\n \\\"WP_AGERAGE_PATHWAY\\\",\\n \\\"KEGG_PANCREATIC_CANCER\\\",\\n \\\"MARSON_BOUND_BY_FOXP3_UNSTIMULATED\\\",\\n \\\"FIGUEROA_AML_METHYLATION_CLUSTER_3_UP\\\",\\n \\\"LINDGREN_BLADDER_CANCER_CLUSTER_3_DN\\\",\\n \\\"REACTOME_GASTRULATION\\\",\\n \\\"REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION\\\",\\n \\\"BENPORATH_MYC_MAX_TARGETS\\\",\\n \\\"WP_INTEGRATED_CANCER_PATHWAY\\\",\\n \\\"KEGG_CHRONIC_MYELOID_LEUKEMIA\\\",\\n \\\"REACTOME_SIGNALING_BY_TGFBR3\\\",\\n \\\"BENPORATH_SOX2_TARGETS\\\",\\n \\\"KEGG_TGF_BETA_SIGNALING_PATHWAY\\\",\\n \\\"WP_ANDROGEN_RECEPTOR_SIGNALING\\\",\\n \\\"PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2\\\",\\n \\\"JOHNSTONE_PARVB_TARGETS_3_UP\\\",\\n \\\"BIOCARTA_TGFB_PATHWAY\\\",\\n \\\"CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN\\\",\\n \\\"REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY\\\",\\n \\\"KEGG_PATHWAYS_IN_CANCER\\\",\\n \\\"WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE\\\",\\n \\\"WP_UROTENSINIIMEDIATED_SIGNALING\\\",\\n \\\"WP_MESODERMAL_COMMITMENT_PATHWAY\\\",\\n \\\"TSAI_RESPONSE_TO_IONIZING_RADIATION\\\",\\n \\\"LAMB_CCND1_TARGETS\\\",\\n \\\"REACTOME_VIRAL_INFECTION_PATHWAYS\\\",\\n \\\"WP_TGFB_SMAD_SIGNALING\\\",\\n \\\"DAZARD_UV_RESPONSE_CLUSTER_G6\\\",\\n \\\"REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS\\\",\\n \\\"REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX\\\",\\n \\\"WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION\\\",\\n \\\"REACTOME_SIGNALING_BY_NOTCH\\\",\\n \\\"FRASOR_RESPONSE_TO_ESTRADIOL_DN\\\",\\n \\\"ZIRN_TRETINOIN_RESPONSE_WT1_UP\\\",\\n \\\"KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3\\\",\\n \\\"BROWNE_HCMV_INFECTION_8HR_DN\\\",\\n \\\"ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF\\\",\\n \\\"REN_ALVEOLAR_RHABDOMYOSARCOMA_DN\\\",\\n \\\"REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION\\\",\\n \\\"PID_HIF1_TFPATHWAY\\\",\\n \\\"GRUETZMANN_PANCREATIC_CANCER_UP\\\",\\n \\\"CHICAS_RB1_TARGETS_CONFLUENT\\\",\\n \\\"YEMELYANOV_GR_TARGETS_DN\\\",\\n \\\"WP_OVARIAN_INFERTILITY\\\",\\n \\\"PHONG_TNF_RESPONSE_NOT_VIA_P38\\\",\\n \\\"WP_ADIPOGENESIS\\\",\\n \\\"DANG_BOUND_BY_MYC\\\",\\n \\\"WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING\\\",\\n \\\"DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN\\\",\\n \\\"BIOCARTA_G1_PATHWAY\\\",\\n \\\"REACTOME_SIGNALING_BY_NOTCH4\\\",\\n \\\"SERVITJA_ISLET_HNF1A_TARGETS_UP\\\",\\n \\\"WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS\\\",\\n \\\"WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY\\\",\\n \\\"WP_NEOVASCULARIZATION_PROCESSES\\\",\\n \\\"REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER\\\",\\n \\\"KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY\\\",\\n \\\"PID_SMAD2_3PATHWAY\\\",\\n \\\"CHANDRAN_METASTASIS_DN\\\",\\n \\\"WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT\\\",\\n \\\"PEREZ_TP53_TARGETS\\\",\\n \\\"KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY\\\",\\n \\\"KIM_WT1_TARGETS_12HR_UP\\\",\\n \\\"WP_BURN_WOUND_HEALING\\\",\\n \\\"REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER\\\",\\n \\\"WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER\\\",\\n \\\"PID_TGFBR_PATHWAY\\\",\\n \\\"WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY\\\",\\n \\\"BROWNE_HCMV_INFECTION_6HR_DN\\\",\\n \\\"REACTOME_FOXO_MEDIATED_TRANSCRIPTION\\\",\\n \\\"REACTOME_TGFBR3_EXPRESSION\\\",\\n \\\"SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1\\\",\\n \\\"KEGG_COLORECTAL_CANCER\\\",\\n \\\"RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN\\\",\\n \\\"REACTOME_SIGNALING_BY_ACTIVIN\\\",\\n \\\"REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS\\\"\\n ],\\n \\\"C3\\\": [\\n \\\"WGGAATGY_TEF1_Q6\\\",\\n \\\"MIR302D_5P\\\",\\n \\\"GTTAAAG_MIR302B\\\",\\n \\\"MIR8080\\\",\\n \\\"PXR_Q2\\\",\\n \\\"SRY_02\\\",\\n \\\"GGCAGAC_MIR346\\\",\\n \\\"HDAC4_TARGET_GENES\\\",\\n \\\"ZNF563_TARGET_GENES\\\",\\n \\\"ZNF766_TARGET_GENES\\\",\\n \\\"MEF2C_TARGET_GENES\\\",\\n \\\"ZFHX3_TARGET_GENES\\\",\\n \\\"TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497\\\",\\n \\\"MIR524_5P\\\",\\n \\\"MIR6129\\\",\\n \\\"ZFP3_TARGET_GENES\\\",\\n \\\"E12_Q6\\\",\\n \\\"ZSCAN30_TARGET_GENES\\\",\\n \\\"GREB1_TARGET_GENES\\\",\\n \\\"MIR3120_5P\\\",\\n \\\"MIR668_3P\\\",\\n \\\"MYOD_Q6_01\\\",\\n \\\"RYTTCCTG_ETS2_B\\\",\\n \\\"MIR6127\\\",\\n \\\"MIR145_5P\\\",\\n \\\"TAL1BETAE47_01\\\",\\n \\\"SKIL_TARGET_GENES\\\",\\n \\\"MIR6130\\\",\\n \\\"ZNF436_TARGET_GENES\\\",\\n \\\"AACTGGA_MIR145\\\",\\n \\\"NR0B1_TARGET_GENES\\\",\\n \\\"KMT2D_TARGET_GENES\\\",\\n \\\"SNAI1_TARGET_GENES\\\",\\n \\\"TAL1ALPHAE47_01\\\",\\n \\\"MED25_TARGET_GENES\\\",\\n \\\"MIR20A_3P\\\",\\n \\\"TFEB_TARGET_GENES\\\",\\n \\\"TBX1_TARGET_GENES\\\",\\n \\\"MIR6886_3P\\\",\\n \\\"AATGTGA_MIR23A_MIR23B\\\",\\n \\\"SUPT16H_TARGET_GENES\\\",\\n \\\"AGCTCCT_MIR28\\\",\\n \\\"NGFIC_01\\\",\\n \\\"MIR3194_3P\\\",\\n \\\"ZNF512B_TARGET_GENES\\\",\\n \\\"TAL1BETAITF2_01\\\",\\n \\\"GATA1_05\\\",\\n \\\"ZNF282_TARGET_GENES\\\",\\n \\\"ZNF740_TARGET_GENES\\\",\\n \\\"ZSCAN2_TARGET_GENES\\\",\\n \\\"MIR6762_5P\\\",\\n \\\"MIR561_3P\\\",\\n \\\"MIR617\\\",\\n \\\"ZNF92_TARGET_GENES\\\",\\n \\\"HMX1_01\\\",\\n \\\"LFA1_Q6\\\",\\n \\\"MIR6845_5P\\\",\\n \\\"DLX2_TARGET_GENES\\\",\\n \\\"SALL4_TARGET_GENES\\\",\\n \\\"MIR520D_5P\\\",\\n \\\"MIR4778_3P\\\",\\n \\\"MIR302B_5P\\\",\\n \\\"MIR6765_3P\\\",\\n \\\"CTTTGTA_MIR524\\\",\\n \\\"MIR4510\\\",\\n \\\"MIR520G_3P_MIR520H\\\",\\n \\\"MIR6133\\\",\\n \\\"MIR5195_3P\\\",\\n \\\"CTAWWWATA_RSRFC4_Q2\\\",\\n \\\"SFMBT1_TARGET_GENES\\\",\\n \\\"ARID5B_TARGET_GENES\\\",\\n \\\"EWSR1_TARGET_GENES\\\",\\n \\\"COUP_DR1_Q6\\\",\\n \\\"MIR3658\\\",\\n \\\"GCTNWTTGK_UNKNOWN\\\",\\n \\\"ZNF596_TARGET_GENES\\\",\\n \\\"ZSCAN5DP_TARGET_GENES\\\",\\n \\\"ATGTCAC_MIR489\\\",\\n \\\"NAB2_TARGET_GENES\\\",\\n \\\"ZNF746_TARGET_GENES\\\",\\n \\\"PBXIP1_TARGET_GENES\\\",\\n \\\"MIR3154\\\",\\n \\\"FXR_IR1_Q6\\\",\\n \\\"MIR5787\\\",\\n \\\"ADNP_TARGET_GENES\\\",\\n \\\"MIR4505\\\"\\n ],\\n \\\"C4\\\": [\\n \\\"MODULE_378\\\",\\n \\\"MODULE_37\\\",\\n \\\"MODULE_57\\\",\\n \\\"MODULE_129\\\",\\n \\\"MODULE_179\\\",\\n \\\"MODULE_3\\\",\\n \\\"MODULE_69\\\",\\n \\\"MODULE_70\\\",\\n \\\"MODULE_117\\\",\\n \\\"MODULE_138\\\",\\n \\\"MODULE_255\\\",\\n \\\"MODULE_459\\\",\\n \\\"MODULE_532\\\",\\n \\\"MODULE_18\\\",\\n \\\"MODULE_136\\\",\\n \\\"MODULE_33\\\",\\n \\\"MODULE_317\\\"\\n ],\\n \\\"C6\\\": [\\n \\\"RPS14_DN.V1_UP\\\"\\n ],\\n \\\"C7\\\": [\\n \\\"GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN\\\",\\n \\\"GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN\\\",\\n \\\"GSE29949_MICROGLIA_VS_DC_BRAIN_DN\\\",\\n \\\"GSE22886_NAIVE_BCELL_VS_DC_UP\\\",\\n \\\"GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP\\\",\\n \\\"GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP\\\",\\n \\\"GSE20366_TREG_VS_TCONV_UP\\\",\\n \\\"GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP\\\",\\n \\\"GSE40443_INDUCED_VS_TOTAL_TREG_UP\\\",\\n \\\"GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP\\\",\\n \\\"GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP\\\",\\n \\\"GSE1460_DP_VS_CD4_THYMOCYTE_DN\\\",\\n \\\"GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN\\\",\\n \\\"GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN\\\",\\n \\\"NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN\\\",\\n \\\"GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN\\\",\\n \\\"GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP\\\",\\n \\\"FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP\\\",\\n \\\"SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP\\\",\\n \\\"GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP\\\",\\n \\\"GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN\\\",\\n \\\"GSE3982_MAC_VS_TH1_DN\\\",\\n \\\"GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP\\\",\\n \\\"GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN\\\",\\n \\\"GSE20727_CTRL_VS_H2O2_TREATED_DC_DN\\\",\\n \\\"GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP\\\",\\n \\\"GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN\\\",\\n \\\"GSE369_IFNG_KO_VS_WT_LIVER_UP\\\",\\n \\\"GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP\\\",\\n \\\"NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP\\\",\\n \\\"GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP\\\",\\n \\\"GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP\\\",\\n \\\"GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP\\\",\\n \\\"GSE7852_LN_VS_FAT_TREG_DN\\\",\\n \\\"GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP\\\",\\n \\\"GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP\\\",\\n \\\"GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN\\\",\\n \\\"GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP\\\",\\n \\\"GSE2585_CTEC_VS_THYMIC_DC_DN\\\",\\n \\\"GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN\\\",\\n \\\"GSE14350_TREG_VS_TEFF_UP\\\",\\n \\\"GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP\\\",\\n \\\"GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN\\\",\\n \\\"GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN\\\",\\n \\\"GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP\\\",\\n \\\"GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN\\\",\\n \\\"GSE14415_INDUCED_TREG_VS_TCONV_DN\\\",\\n \\\"GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN\\\",\\n \\\"GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP\\\",\\n \\\"GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP\\\",\\n \\\"GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP\\\",\\n \\\"GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP\\\",\\n \\\"GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN\\\",\\n \\\"GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP\\\",\\n \\\"GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN\\\",\\n \\\"GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN\\\",\\n \\\"GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN\\\",\\n \\\"GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN\\\",\\n \\\"GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP\\\",\\n \\\"GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN\\\",\\n \\\"NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN\\\",\\n \\\"GSE17186_MEMORY_VS_NAIVE_BCELL_UP\\\",\\n \\\"GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP\\\",\\n \\\"GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN\\\",\\n \\\"GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN\\\",\\n \\\"GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP\\\",\\n \\\"GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP\\\",\\n \\\"GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP\\\",\\n \\\"GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP\\\",\\n \\\"GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN\\\",\\n \\\"GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP\\\",\\n \\\"GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP\\\",\\n \\\"GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN\\\",\\n \\\"GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN\\\",\\n \\\"GSE7852_THYMUS_VS_FAT_TREG_DN\\\",\\n \\\"GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP\\\",\\n \\\"GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP\\\",\\n \\\"GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP\\\",\\n \\\"GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP\\\",\\n \\\"GSE360_CTRL_VS_L_MAJOR_MAC_UP\\\",\\n \\\"GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN\\\",\\n \\\"GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN\\\",\\n \\\"GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP\\\",\\n \\\"GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP\\\",\\n \\\"GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP\\\",\\n \\\"GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP\\\",\\n \\\"GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN\\\",\\n \\\"GSE40273_EOS_KO_VS_WT_TREG_UP\\\",\\n \\\"GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP\\\",\\n \\\"GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP\\\",\\n \\\"GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN\\\",\\n \\\"GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN\\\",\\n \\\"GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP\\\",\\n \\\"GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP\\\",\\n \\\"GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN\\\",\\n \\\"GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP\\\",\\n \\\"GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP\\\",\\n \\\"GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN\\\",\\n \\\"GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN\\\",\\n \\\"GSE12505_WT_VS_E2_2_HET_PDC_UP\\\",\\n \\\"GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP\\\",\\n \\\"GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN\\\",\\n \\\"GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP\\\",\\n \\\"GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN\\\",\\n \\\"GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP\\\",\\n \\\"GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP\\\",\\n \\\"GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP\\\",\\n \\\"GSE27786_CD4_TCELL_VS_NKTCELL_DN\\\",\\n \\\"GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN\\\",\\n \\\"GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP\\\",\\n \\\"NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN\\\",\\n \\\"GSE2585_CTEC_VS_MTEC_THYMUS_UP\\\",\\n \\\"GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN\\\",\\n \\\"NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP\\\",\\n \\\"GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN\\\",\\n \\\"GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP\\\",\\n \\\"GSE7764_NKCELL_VS_SPLENOCYTE_UP\\\",\\n \\\"GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN\\\",\\n \\\"GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP\\\",\\n \\\"GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN\\\",\\n \\\"GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN\\\",\\n \\\"GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP\\\",\\n \\\"GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN\\\",\\n \\\"GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN\\\",\\n \\\"GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP\\\",\\n \\\"GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP\\\"\\n ],\\n \\\"C8\\\": [\\n \\\"FAN_OVARY_CL11_MURAL_GRANULOSA_CELL\\\",\\n \\\"MURARO_PANCREAS_DUCTAL_CELL\\\",\\n \\\"GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS\\\",\\n \\\"FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2\\\",\\n \\\"HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL\\\",\\n \\\"HU_FETAL_RETINA_FIBROBLAST\\\",\\n \\\"HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL\\\",\\n \\\"MURARO_PANCREAS_ACINAR_CELL\\\",\\n \\\"HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL\\\",\\n \\\"HU_FETAL_RETINA_RPE\\\"\\n ]\\n }\\n },\\n \\\"omim\\\": {\\n \\\"phenotype_annotations\\\": []\\n },\\n \\\"disgenet\\\": {\\n \\\"disease_annotations\\\": []\\n },\\n \\\"open_targets\\\": {\\n \\\"disease_annotations\\\": [\\n \\\"Large for gestational age\\\",\\n \\\"Alopecia\\\",\\n \\\"Abnormality of the cardiovascular system\\\",\\n \\\"Mitral valve prolapse\\\",\\n \\\"Congestive heart failure\\\",\\n \\\"Patent ductus arteriosus\\\",\\n \\\"Dilated cardiomyopathy\\\",\\n \\\"Bicuspid aortic valve\\\",\\n \\\"Right ventricular hypertrophy\\\",\\n \\\"Myocardial fibrosis\\\",\\n \\\"Hallux valgus\\\",\\n \\\"Increased total eosinophil count\\\",\\n \\\"Acute kidney injury\\\",\\n \\\"Renal artery stenosis\\\",\\n \\\"Hypoglycemia\\\",\\n \\\"Glucose intolerance\\\",\\n \\\"Abnormal thrombosis\\\",\\n \\\"Rectal prolapse\\\",\\n \\\"Esophageal stricture\\\",\\n \\\"Pulmonary hypoplasia\\\",\\n \\\"Asthma\\\",\\n \\\"Cerebral cortical atrophy\\\",\\n \\\"Ischemic stroke\\\",\\n \\\"Aortic root aneurysm\\\",\\n \\\"Aortic dissection\\\",\\n \\\"Spontaneous pneumothorax\\\",\\n \\\"Vascular dilatation\\\",\\n \\\"Cerebral ischemia\\\",\\n \\\"Immunodeficiency\\\",\\n \\\"Systemic lupus erythematosus\\\",\\n \\\"Oral leukoplakia\\\",\\n \\\"Autoimmunity\\\",\\n \\\"Hyperglycemia\\\",\\n \\\"Hyperlipidemia\\\",\\n \\\"Hypercholesterolemia\\\",\\n \\\"Back pain\\\",\\n \\\"Muscular dystrophy\\\",\\n \\\"Hernia of the abdominal wall\\\",\\n \\\"Cachexia\\\",\\n \\\"Ascending aortic dissection\\\",\\n \\\"Venous thrombosis\\\",\\n \\\"Ascending tubular aorta aneurysm\\\",\\n \\\"Ureteral obstruction\\\",\\n \\\"Airway obstruction\\\",\\n \\\"Pituitary prolactin cell adenoma\\\",\\n \\\"Premature ovarian insufficiency\\\",\\n \\\"Intervertebral disk degeneration\\\",\\n \\\"Lipodystrophy\\\",\\n \\\"Hamartoma\\\",\\n \\\"Chordoma\\\",\\n \\\"Stress urinary incontinence\\\",\\n \\\"Inflammatory abnormality of the skin\\\",\\n \\\"Arrhythmia\\\",\\n \\\"Myelofibrosis\\\",\\n \\\"Hepatitis\\\",\\n \\\"Urethral stricture\\\",\\n \\\"Allergy\\\",\\n \\\"Renal atrophy\\\",\\n \\\"Pulmonary bulla\\\",\\n \\\"Chronic colitis\\\",\\n \\\"Neoplasm of the lung\\\",\\n \\\"Cognitive impairment\\\",\\n \\\"Hernia\\\",\\n \\\"Sepsis\\\",\\n \\\"Skin ulcer\\\",\\n \\\"Left ventricular dilatation\\\",\\n \\\"colorectal adenoma\\\",\\n \\\"airway hyperresponsiveness\\\",\\n \\\"skin aging\\\",\\n \\\"adolescent idiopathic scoliosis\\\",\\n \\\"triple-negative breast cancer\\\",\\n \\\"bile duct carcinoma\\\",\\n \\\"glioma\\\",\\n \\\"gamma chain deficiency\\\",\\n \\\"seborrheic keratosis\\\",\\n \\\"rectal adenocarcinoma\\\",\\n \\\"intracerebral hemorrhage\\\",\\n \\\"smoking initiation\\\",\\n \\\"Staphylococcus aureus infection\\\",\\n \\\"rheumatic disease\\\",\\n \\\"lupus nephritis\\\",\\n \\\"pulse pressure measurement\\\",\\n \\\"neurodegenerative disease\\\",\\n \\\"retinal detachment\\\",\\n \\\"Autoimmune Hepatitis\\\",\\n \\\"non-high density lipoprotein cholesterol measurement\\\",\\n \\\"brain disease\\\",\\n \\\"aortic disease\\\",\\n \\\"neonatal abstinence syndrome\\\",\\n \\\"allergic rhinitis\\\",\\n \\\"esophageal squamous cell carcinoma\\\",\\n \\\"non-Hodgkins lymphoma\\\",\\n \\\"breast ductal adenocarcinoma\\\",\\n \\\"systolic blood pressure\\\",\\n \\\"diastolic blood pressure\\\",\\n \\\"pulmonary artery enlargement\\\",\\n \\\"laryngeal squamous cell carcinoma\\\",\\n \\\"cystadenocarcinoma\\\",\\n \\\"ovarian mucinous adenocarcinoma\\\",\\n \\\"smoking status measurement\\\",\\n \\\"bladder transitional cell carcinoma\\\",\\n \\\"brain glioblastoma\\\",\\n \\\"cerebral amyloid angiopathy\\\",\\n \\\"autoimmune thyroid disease\\\",\\n \\\"stricture\\\",\\n \\\"head and neck malignant neoplasia\\\",\\n \\\"urgency urinary incontinence\\\",\\n \\\"fibrosis\\\",\\n \\\"diastolic blood pressure change measurement\\\",\\n \\\"drug use measurement\\\",\\n \\\"allergic conjunctivitis\\\",\\n \\\"aortic valve insufficiency\\\",\\n \\\"Balkan nephropathy\\\",\\n \\\"bronchiolitis obliterans\\\",\\n \\\"congenital rubella\\\",\\n \\\"coronavirus infectious disease\\\",\\n \\\"echinococcosis\\\",\\n \\\"endodermal sinus tumor\\\",\\n \\\"Gerstmann syndrome\\\",\\n \\\"Guillain-Barre syndrome\\\",\\n \\\"influenza\\\",\\n \\\"intestinal cancer\\\",\\n \\\"legionellosis\\\",\\n \\\"lymphatic system disease\\\",\\n \\\"male reproductive organ cancer\\\",\\n \\\"aneurysm-osteoarthritis syndrome\\\",\\n \\\"autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome\\\",\\n \\\"hyperuricemic nephropathy, familial juvenile type 3\\\",\\n \\\"graft versus host disease\\\",\\n \\\"autoimmune lymphoproliferative syndrome type 4\\\",\\n \\\"combined immunodeficiency due to LRBA deficiency\\\",\\n \\\"adenine phosphoribosyltransferase deficiency\\\",\\n \\\"karyomegalic interstitial nephritis\\\",\\n \\\"dyskeratosis congenita, autosomal recessive 5\\\",\\n \\\"TCR-alpha-beta-positive T-cell deficiency\\\",\\n \\\"severe combined immunodeficiency due to IKK2 deficiency\\\",\\n \\\"immunodeficiency 18\\\",\\n \\\"immunodeficiency 23\\\",\\n \\\"severe combined immunodeficiency due to CTPS1 deficiency\\\",\\n \\\"severe neurodegenerative syndrome with lipodystrophy\\\",\\n \\\"periodic fever-infantile enterocolitis-autoinflammatory syndrome\\\",\\n \\\"immunodeficiency 37\\\",\\n \\\"chronic atrial and intestinal dysrhythmia\\\",\\n \\\"DOCK2 deficiency\\\",\\n \\\"DDX41-related hematologic malignancy predisposition syndrome\\\",\\n \\\"fibrochondrogenesis 2\\\",\\n \\\"C3 glomerulonephritis\\\",\\n \\\"agammaglobulinemia 7, autosomal recessive\\\",\\n \\\"autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency\\\",\\n \\\"infantile-onset periodic fever-panniculitis-dermatosis syndrome\\\",\\n \\\"lung disease, immunodeficiency, and chromosome breakage syndrome;\\\",\\n \\\"neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade\\\",\\n \\\"chronic diarrhea due to glucoamylase deficiency\\\",\\n \\\"Bardet-Biedl syndrome\\\",\\n \\\"familial pancreatic carcinoma\\\",\\n \\\"nasopharyngeal carcinoma\\\",\\n \\\"craniosynostosis\\\",\\n \\\"keratoconus\\\",\\n \\\"common variable immunodeficiency\\\",\\n \\\"hyperplastic polyposis syndrome\\\",\\n \\\"dentin dysplasia\\\",\\n \\\"T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency\\\",\\n \\\"early myoclonic encephalopathy\\\",\\n \\\"laryngotracheoesophageal cleft\\\",\\n \\\"cleft palate\\\",\\n \\\"qualitative or quantitative defects of dysferlin\\\",\\n \\\"holoprosencephaly\\\",\\n \\\"attenuated familial adenomatous polyposis\\\",\\n \\\"isolated agammaglobulinemia\\\",\\n \\\"pachyonychia congenita\\\",\\n \\\"familial hyperaldosteronism\\\",\\n \\\"hypohidrotic ectodermal dysplasia\\\",\\n \\\"primary ciliary dyskinesia\\\",\\n \\\"APC-related attenuated familial adenomatous polyposis\\\",\\n \\\"meningioma\\\",\\n \\\"multiple epiphyseal dysplasia\\\",\\n \\\"hemangioblastoma\\\",\\n \\\"Moyamoya disease\\\",\\n \\\"thanatophoric dysplasia\\\",\\n \\\"idiopathic pulmonary arterial hypertension\\\",\\n \\\"IgG4-related disease\\\",\\n \\\"juvenile polyposis syndrome\\\",\\n \\\"pituitary tumor\\\",\\n \\\"ameloblastoma\\\",\\n \\\"exstrophy-epispadias complex\\\",\\n \\\"autoimmune lymphoproliferative syndrome\\\",\\n \\\"syringomyelia\\\",\\n \\\"selective IgM deficiency\\\",\\n \\\"persistent truncus arteriosus\\\",\\n \\\"colorectal adenocarcinoma\\\",\\n \\\"congestive heart failure\\\",\\n \\\"Crohn's disease\\\",\\n \\\"cutaneous melanoma\\\",\\n \\\"diabetes mellitus\\\",\\n \\\"diabetic nephropathy\\\",\\n \\\"diffuse gastric adenocarcinoma\\\",\\n \\\"diffuse large B-cell lymphoma\\\",\\n \\\"breast ductal carcinoma in situ\\\",\\n \\\"embryonal rhabdomyosarcoma\\\",\\n \\\"emphysema\\\",\\n \\\"epilepsy\\\",\\n \\\"fetal growth restriction\\\",\\n \\\"ganglioneuroma\\\",\\n \\\"gastric adenocarcinoma\\\",\\n \\\"esophageal adenocarcinoma\\\",\\n \\\"gastric intestinal type adenocarcinoma\\\",\\n \\\"glioblastoma multiforme\\\",\\n \\\"hypertension\\\",\\n \\\"hypertrophic cardiomyopathy\\\",\\n \\\"immune system disease\\\",\\n \\\"infection\\\",\\n \\\"infertility\\\",\\n \\\"injury\\\",\\n \\\"insulinoma\\\",\\n \\\"intracranial hemorrhage\\\",\\n \\\"ischemia\\\",\\n \\\"leukemia\\\",\\n \\\"lung adenocarcinoma\\\",\\n \\\"lymphoma\\\",\\n \\\"mesothelioma\\\",\\n \\\"metabolic disease\\\",\\n \\\"myocardial infarction\\\",\\n \\\"neoplasm\\\",\\n \\\"nervous system disease\\\",\\n \\\"neuroblastoma\\\",\\n \\\"oligodendroglioma\\\",\\n \\\"osteosarcoma\\\",\\n \\\"tuberculosis\\\",\\n \\\"glioblastoma\\\",\\n \\\"chronic granulomatous disease\\\",\\n \\\"liver mesenchymal hamartoma\\\",\\n \\\"activated PI3K-delta syndrome\\\",\\n \\\"carcinoma of liver and intrahepatic biliary tract\\\",\\n \\\"cutaneous polyarteritis nodosa\\\",\\n \\\"hereditary nonpolyposis colon cancer\\\",\\n \\\"Polymerase proofreading-related adenomatous polyposis\\\",\\n \\\"Zika virus infectious disease\\\",\\n \\\"regressive spondylometaphyseal dysplasia\\\",\\n \\\"Jeune syndrome\\\",\\n \\\"Li-Fraumeni syndrome\\\",\\n \\\"posterior cortical atrophy\\\",\\n \\\"22q11.2 deletion syndrome\\\",\\n \\\"Loeys-Dietz syndrome\\\",\\n \\\"congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization\\\",\\n \\\"intrahepatic cholestasis\\\",\\n \\\"bronchopulmonary dysplasia\\\",\\n \\\"Hirschsprung disease\\\",\\n \\\"mucinous adenocarcinoma of the appendix\\\",\\n \\\"Lhermitte-Duclos disease\\\",\\n \\\"sarcoidosis\\\",\\n \\\"peeling skin syndrome\\\",\\n \\\"Fanconi anemia\\\",\\n \\\"dysspondyloenchondromatosis\\\",\\n \\\"adult T-cell leukemia/lymphoma\\\",\\n \\\"extranodal nasal NK/T cell lymphoma\\\",\\n \\\"Turner syndrome\\\",\\n \\\"acute liver failure\\\",\\n \\\"discoid lupus erythematosus\\\",\\n \\\"familial thoracic aortic aneurysm and aortic dissection\\\",\\n \\\"renal hypoplasia\\\",\\n \\\"renal dysplasia\\\",\\n \\\"spondyloepiphyseal dysplasia tarda\\\",\\n \\\"ulnar hemimelia\\\",\\n \\\"radial hemimelia\\\",\\n \\\"growth hormone-producing pituitary gland neoplasm\\\",\\n \\\"encephalitis\\\",\\n \\\"Ehlers-Danlos syndrome\\\",\\n \\\"muscular dystrophy\\\",\\n \\\"autosomal dominant cerebellar ataxia\\\",\\n \\\"precursor B-cell acute lymphoblastic leukemia\\\",\\n \\\"chronic graft versus host disease\\\",\\n \\\"superficial spreading melanoma\\\",\\n \\\"renal pelvis/ureter urothelial carcinoma\\\",\\n \\\"tubulointerstitial kidney disease, autosomal dominant, 2\\\",\\n \\\"lung neoplasm\\\",\\n \\\"intestinal neoplasm\\\",\\n \\\"prostate neoplasm\\\",\\n \\\"mucoepidermoid carcinoma of parotid gland\\\",\\n \\\"neoplasm of esophagus\\\",\\n \\\"tumor of parathyroid gland\\\",\\n \\\"polyp of colon\\\",\\n \\\"low grade glioma\\\",\\n \\\"coronary atherosclerosis\\\",\\n \\\"gram-negative bacterial infections\\\",\\n \\\"sexually transmitted disease\\\",\\n \\\"radiculitis\\\",\\n \\\"viral myocarditis\\\",\\n \\\"lip and oral cavity carcinoma\\\",\\n \\\"immunodeficiency 14b, autosomal recessive\\\",\\n \\\"corneal infection\\\",\\n \\\"pseudoxanthoma elasticum (inherited or acquired)\\\",\\n \\\"respiratory tract infectious disorder\\\",\\n \\\"chondrogenic neoplasm\\\",\\n \\\"squamous cell intraepithelial neoplasia\\\",\\n \\\"liver and intrahepatic bile duct neoplasm\\\",\\n \\\"hypertensive nephropathy\\\",\\n \\\"myocardial disorder\\\",\\n \\\"tubular adenoma\\\",\\n \\\"synucleinopathy\\\",\\n \\\"pulmonary sarcoidosis\\\",\\n \\\"gonorrhea\\\",\\n \\\"chronic lymphocytic leukemia\\\",\\n \\\"neoplasm of mature B-cells\\\",\\n \\\"gastric carcinoma\\\",\\n \\\"head and neck squamous cell carcinoma\\\",\\n \\\"hepatocellular carcinoma\\\",\\n \\\"metastatic prostate cancer\\\",\\n \\\"T-cell acute lymphoblastic leukemia\\\",\\n \\\"unspecified peripheral T-cell lymphoma\\\",\\n \\\"Hodgkins lymphoma\\\",\\n \\\"invasive breast ductal carcinoma\\\",\\n \\\"metabolic syndrome\\\",\\n \\\"oral squamous cell carcinoma\\\",\\n \\\"acute lymphoblastic leukemia\\\",\\n \\\"acute myeloid leukemia\\\",\\n \\\"adenocarcinoma\\\",\\n \\\"adenoma\\\",\\n \\\"adenosquamous lung carcinoma\\\",\\n \\\"adrenal gland pheochromocytoma\\\",\\n \\\"alveolar rhabdomyosarcoma\\\",\\n \\\"aortic stenosis\\\",\\n \\\"astrocytoma\\\",\\n \\\"atopic eczema\\\",\\n \\\"atrial fibrillation\\\",\\n \\\"benign prostatic hyperplasia\\\",\\n \\\"breast adenocarcinoma\\\",\\n \\\"breast carcinoma\\\",\\n \\\"bronchoalveolar adenocarcinoma\\\",\\n \\\"Burkitts lymphoma\\\",\\n \\\"carcinoma\\\",\\n \\\"cardiomyopathy\\\",\\n \\\"cardiovascular disease\\\",\\n \\\"chondrosarcoma\\\",\\n \\\"chronic myelogenous leukemia\\\",\\n \\\"chronic obstructive pulmonary disease\\\",\\n \\\"chronic pancreatitis\\\",\\n \\\"clear cell renal carcinoma\\\",\\n \\\"endometrial carcinoma\\\",\\n \\\"renal fibrosis\\\",\\n \\\"Adenomyosis\\\",\\n \\\"immunoproliferative small intestinal disease\\\",\\n \\\"Posterior Leukoencephalopathy Syndrome\\\",\\n \\\"amyloidosis\\\",\\n \\\"neuroendocrine neoplasm\\\",\\n \\\"Spinal cord injury\\\",\\n \\\"B-cell non-Hodgkins lymphoma\\\",\\n \\\"colon adenocarcinoma\\\",\\n \\\"colon carcinoma\\\",\\n \\\"colorectal carcinoma\\\",\\n \\\"intrahepatic cholangiocarcinoma\\\",\\n \\\"pharyngeal squamous cell carcinoma\\\",\\n \\\"connective tissue disease\\\",\\n \\\"pneumonitis\\\",\\n \\\"Carcinoma, Lewis Lung\\\",\\n \\\"soft tissue sarcoma\\\",\\n \\\"adult onset asthma\\\",\\n \\\"chronic rhinosinusitis with nasal polyps\\\",\\n \\\"chronic rhinosinusitis without nasal polyps\\\",\\n \\\"renal hypertension\\\",\\n \\\"glomerular disease\\\",\\n \\\"nephritis\\\",\\n \\\"positive regulation of ovulation\\\",\\n \\\"Neurogenic bladder\\\",\\n \\\"Inguinal hernia\\\",\\n \\\"Abnormality of the urinary system\\\",\\n \\\"Renal insufficiency\\\",\\n \\\"Glomerular sclerosis\\\",\\n \\\"Glomerulonephritis\\\",\\n \\\"Nephropathy\\\",\\n \\\"Nephrocalcinosis\\\",\\n \\\"Uterine leiomyoma\\\",\\n \\\"Cleft palate\\\",\\n \\\"Retrognathia\\\",\\n \\\"Strabismus\\\",\\n \\\"Cataract\\\",\\n \\\"Proptosis\\\",\\n \\\"Myopia\\\",\\n \\\"Pectus excavatum\\\",\\n \\\"Infertility\\\",\\n \\\"Hematuria\\\",\\n \\\"Diabetes mellitus\\\",\\n \\\"Hyperinsulinemia\\\",\\n \\\"Insulin resistance\\\",\\n \\\"Abnormality of the skeletal system\\\",\\n \\\"Osteopenia\\\",\\n \\\"Osteoporosis\\\",\\n \\\"Jaundice\\\",\\n \\\"Eczematoid dermatitis\\\",\\n \\\"Global developmental delay\\\",\\n \\\"Stroke\\\",\\n \\\"Encephalopathy\\\",\\n \\\"Parkinsonism\\\",\\n \\\"Rheumatoid arthritis\\\",\\n \\\"Cirrhosis\\\",\\n \\\"Hepatic fibrosis\\\",\\n \\\"Cholestasis\\\",\\n \\\"Hepatic steatosis\\\",\\n \\\"Obesity\\\",\\n \\\"ornithine carbamoyltransferase deficiency\\\",\\n \\\"pseudomyxoma peritonei\\\",\\n \\\"silicosis\\\",\\n \\\"spinal stenosis\\\",\\n \\\"BMI-adjusted waist-hip ratio\\\",\\n \\\"BMI-adjusted waist circumference\\\",\\n \\\"body fat percentage\\\",\\n \\\"balding measurement\\\",\\n \\\"liver dysplastic nodule\\\",\\n \\\"wellbeing measurement\\\",\\n \\\"insomnia measurement\\\",\\n \\\"eosinophil percentage of leukocytes\\\",\\n \\\"eosinophil percentage of granulocytes\\\",\\n \\\"BMI-adjusted hip circumference\\\",\\n \\\"calf circumference measurement\\\",\\n \\\"chronic hepatitis\\\",\\n \\\"dysplasia\\\",\\n \\\"interstitial cystitis\\\",\\n \\\"lobular breast carcinoma\\\",\\n \\\"nodular melanoma\\\",\\n \\\"non-functioning pituitary adenoma\\\",\\n \\\"oral lichen planus\\\",\\n \\\"rhinitis\\\",\\n \\\"small cell carcinoma\\\",\\n \\\"status epilepticus\\\",\\n \\\"steatosis\\\",\\n \\\"urothelial carcinoma\\\",\\n \\\"Hepatobiliary Neoplasm\\\",\\n \\\"acute myocardial infarction\\\",\\n \\\"peritonitis\\\",\\n \\\"pemphigus foliaceus\\\",\\n \\\"paraneoplastic pemphigus\\\",\\n \\\"cystic kidney disease\\\",\\n \\\"ovarian dysfunction\\\",\\n \\\"Arteritis\\\",\\n \\\"Polyarteritis Nodosa\\\",\\n \\\"arteriosclerosis\\\",\\n \\\"idiopathic dilated cardiomyopathy\\\",\\n \\\"hyperuricemia\\\",\\n \\\"female reproductive endometrioid cancer\\\",\\n \\\"skin carcinoma\\\",\\n \\\"heel bone mineral density\\\",\\n \\\"marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections\\\",\\n \\\"central nervous system disease\\\",\\n \\\"sum of eosinophil and basophil counts\\\",\\n \\\"lower respiratory tract disease\\\",\\n \\\"pulmonary fibrosis\\\",\\n \\\"infarction\\\",\\n \\\"corneal disease\\\",\\n \\\"vertebral joint disease\\\",\\n \\\"aortic valve disease\\\",\\n \\\"cervical disc degenerative disorder\\\",\\n \\\"hemorrhoid\\\",\\n \\\"mitral valve disease\\\",\\n \\\"feeling nervous measurement\\\",\\n \\\"stomach disease\\\",\\n \\\"myocarditis\\\",\\n \\\"aneurysm\\\",\\n \\\"laryngeal disease\\\",\\n \\\"musculoskeletal system disease\\\",\\n \\\"Gallbladder Adenocarcinoma\\\",\\n \\\"Gallbladder Adenoma\\\",\\n \\\"Gastric Neuroendocrine Tumor G1\\\",\\n \\\"Granular Cell Tumor\\\",\\n \\\"Hepatoblastoma\\\",\\n \\\"HER2 Positive Breast Carcinoma\\\",\\n \\\"Invasive Breast Carcinoma\\\",\\n \\\"Mast Cell Sarcoma\\\",\\n \\\"Nasal Cavity Polyp\\\",\\n \\\"Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation\\\",\\n \\\"Ovarian Endometriosis\\\",\\n \\\"Ovarian Granulosa Cell Tumor\\\",\\n \\\"Peritoneal Multicystic Mesothelioma\\\",\\n \\\"Pituitary Gland Adenoma\\\",\\n \\\"Placental Choriocarcinoma\\\",\\n \\\"Pleural Epithelioid Mesothelioma\\\",\\n \\\"Poorly Differentiated Thyroid Gland Carcinoma\\\",\\n \\\"Rectal Tubular Adenoma\\\",\\n \\\"Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions\\\",\\n \\\"Signet Ring Cell Gastric Adenocarcinoma\\\",\\n \\\"small intestinal adenocarcinoma\\\",\\n \\\"Spinal Chordoma\\\",\\n \\\"Testicular Embryonal Carcinoma\\\",\\n \\\"Thyroid Gland Oncocytic Follicular Carcinoma\\\",\\n \\\"Thyroid Gland Undifferentiated (Anaplastic) Carcinoma\\\",\\n \\\"Uterine Carcinosarcoma\\\",\\n \\\"Vaginal Melanoma\\\",\\n \\\"hamartoma\\\",\\n \\\"acute respiratory distress syndrome\\\",\\n \\\"rectum cancer\\\",\\n \\\"acanthosis nigricans\\\",\\n \\\"cholesteatoma\\\",\\n \\\"Primary Pulmonary Diffuse Large B-Cell Lymphoma\\\",\\n \\\"developmental dysplasia of the hip\\\",\\n \\\"sarcopenia\\\",\\n \\\"mucous membrane pemphigoid\\\",\\n \\\"osteoarthritis, hip\\\",\\n \\\"osteoarthritis, spine\\\",\\n \\\"adrenal cortex carcinoma\\\",\\n \\\"adrenal gland hyperfunction\\\",\\n \\\"alcoholic cardiomyopathy\\\",\\n \\\"aortitis\\\",\\n \\\"atrial heart septal defect\\\",\\n \\\"causalgia\\\",\\n \\\"coronary aneurysm\\\",\\n \\\"diastolic heart failure\\\",\\n \\\"dry eye syndrome\\\",\\n \\\"Helicobacter pylori infectious disease\\\",\\n \\\"inflammatory breast carcinoma\\\",\\n \\\"joint disease\\\",\\n \\\"lipoid nephrosis\\\",\\n \\\"mouth disease\\\",\\n \\\"multiple system atrophy\\\",\\n \\\"myeloid sarcoma\\\",\\n \\\"ocular hypertension\\\",\\n \\\"parathyroid adenoma\\\",\\n \\\"proliferative vitreoretinopathy\\\",\\n \\\"pulmonary edema\\\",\\n \\\"pulpitis\\\",\\n \\\"Raynaud disease\\\",\\n \\\"renovascular hypertension\\\",\\n \\\"rheumatic heart disease\\\",\\n \\\"Schnitzler syndrome\\\",\\n \\\"thromboangiitis obliterans\\\",\\n \\\"ulcerative proctosigmoiditis\\\",\\n \\\"uremia\\\",\\n \\\"non-alcoholic steatohepatitis\\\",\\n \\\"rotator cuff tear\\\",\\n \\\"Anemia, Hemolytic, Autoimmune\\\",\\n \\\"Cardiac Tamponade\\\",\\n \\\"End Stage Liver Disease\\\",\\n \\\"Endometritis\\\",\\n \\\"Escherichia coli Infections\\\",\\n \\\"Genital neoplasm, female\\\",\\n \\\"Heavy Chain Disease\\\",\\n \\\"Hepatopulmonary Syndrome\\\",\\n \\\"Lentivirus Infections\\\",\\n \\\"Myocardial Ischemia\\\",\\n \\\"Periapical Periodontitis\\\",\\n \\\"Peritoneal Fibrosis\\\",\\n \\\"Tularemia\\\",\\n \\\"diabetic cardiomyopathy\\\",\\n \\\"endothelial dysfunction\\\",\\n \\\"gliosarcoma\\\",\\n \\\"Mantle cell lymphoma\\\",\\n \\\"Merkel cell skin cancer\\\",\\n \\\"metastatic colorectal cancer\\\",\\n \\\"enterocolitis\\\",\\n \\\"primary biliary cirrhosis\\\",\\n \\\"abortion\\\",\\n \\\"psoriasis vulgaris\\\",\\n \\\"Autosomal dominant polycystic kidney disease\\\",\\n \\\"osteoporosis-pseudoglioma syndrome\\\",\\n \\\"primary hyperoxaluria type 2\\\",\\n \\\"hyperimmunoglobulinemia D with periodic fever\\\",\\n \\\"autosomal recessive polycystic kidney disease\\\",\\n \\\"Senior-Loken syndrome 1\\\",\\n \\\"reticular dysgenesis\\\",\\n \\\"schneckenbecken dysplasia\\\",\\n \\\"combined immunodeficiency due to ZAP70 deficiency\\\",\\n \\\"familial isolated congenital asplenia\\\",\\n \\\"brachyolmia type 1, Hobaek type\\\",\\n \\\"brachyolmia type 1, toledo type\\\",\\n \\\"spondyloperipheral dysplasia\\\",\\n \\\"thoracomelic dysplasia\\\",\\n \\\"congenital bilateral aplasia of vas deferens from CFTR mutation\\\",\\n \\\"Wilson disease\\\",\\n \\\"X-linked spondyloepimetaphyseal dysplasia\\\",\\n \\\"hypoxanthine guanine phosphoribosyltransferase partial deficiency\\\",\\n \\\"Bruton-type agammaglobulinemia\\\",\\n \\\"X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia\\\",\\n \\\"combined immunodeficiency due to moesin deficiency\\\",\\n \\\"Wiskott-Aldrich syndrome\\\",\\n \\\"Aarskog-Scott syndrome, X-linked\\\",\\n \\\"hyper-IgM syndrome type 1\\\",\\n \\\"Melnick-Needles syndrome\\\",\\n \\\"Bartsocas-Papas syndrome 1\\\",\\n \\\"pulmonary venoocclusive disease\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Irapa type\\\",\\n \\\"SHOX-related short stature\\\",\\n \\\"immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome\\\",\\n \\\"Duchenne muscular dystrophy\\\",\\n \\\"X-linked retinoschisis\\\",\\n \\\"spondyloepiphyseal dysplasia tarda, X-linked\\\",\\n \\\"T-B+ severe combined immunodeficiency due to JAK3 deficiency\\\",\\n \\\"Timothy syndrome\\\",\\n \\\"supranuclear palsy, progressive, 1\\\",\\n \\\"skeletal dysplasia-epilepsy-short stature syndrome\\\",\\n \\\"hereditary mixed polyposis syndrome\\\",\\n \\\"severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive\\\",\\n \\\"Ehlers-Danlos syndrome, musculocontractural type\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Missouri type\\\",\\n \\\"axial spondylometaphyseal dysplasia\\\",\\n \\\"severe combined immunodeficiency due to DCLRE1C deficiency\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Shohat type\\\",\\n \\\"myotonic dystrophy type 2\\\",\\n \\\"radioulnar synostosis-microcephaly-scoliosis syndrome\\\",\\n \\\"spondyloepimetaphyseal dysplasia with multiple dislocations\\\",\\n \\\"Omenn syndrome\\\",\\n \\\"xanthinuria type II\\\",\\n \\\"autoimmune lymphoproliferative syndrome type 2A\\\",\\n \\\"nephronophthisis 3\\\",\\n \\\"pyogenic arthritis-pyoderma gangrenosum-acne syndrome\\\",\\n \\\"hyper-IgM syndrome type 2\\\",\\n \\\"immunodeficiency due to CD25 deficiency\\\",\\n \\\"lymphangioleiomyomatosis\\\",\\n \\\"gastrointestinal stromal tumor\\\",\\n \\\"hyper-IgM syndrome type 3\\\",\\n \\\"multiple epiphyseal dysplasia type 5\\\",\\n \\\"anauxetic dysplasia\\\",\\n \\\"autoimmune lymphoproliferative syndrome type 2B\\\",\\n \\\"Smith-McCort dysplasia 1\\\",\\n \\\"granular corneal dystrophy type II\\\",\\n \\\"acrocapitofemoral dysplasia\\\",\\n \\\"endometrial cancer\\\",\\n \\\"hyper-IgM syndrome type 5\\\",\\n \\\"hyper-IgM syndrome type 4\\\",\\n \\\"neutrophil immunodeficiency syndrome\\\",\\n \\\"familial adenomatous polyposis 2\\\",\\n \\\"spondyloepimetaphyseal dysplasia, matrilin-3 type\\\",\\n \\\"familial avascular necrosis of femoral head\\\",\\n \\\"immunodeficiency 104\\\",\\n \\\"spondylometaphyseal dysplasia, A4 type\\\",\\n \\\"epidermolysis bullosa simplex 7, with nephropathy and deafness\\\",\\n \\\"permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome\\\",\\n \\\"mesoaxial synostotic syndactyly with phalangeal reduction\\\",\\n \\\"hyperinsulinemic hypoglycemia, familial, 4\\\",\\n \\\"Mungan syndrome\\\",\\n \\\"familial cold autoinflammatory syndrome 2\\\",\\n \\\"aortic aneurysm, familial thoracic 6\\\",\\n \\\"hypouricemia, renal, 2\\\",\\n \\\"dopa-responsive dystonia due to sepiapterin reductase deficiency\\\",\\n \\\"combined immunodeficiency due to STIM1 deficiency\\\",\\n \\\"atypical hemolytic-uremic syndrome with MCP/CD46 anomaly\\\",\\n \\\"atypical hemolytic-uremic syndrome with I factor anomaly\\\",\\n \\\"atypical hemolytic-uremic syndrome with B factor anomaly\\\",\\n \\\"atypical hemolytic-uremic syndrome with C3 anomaly\\\",\\n \\\"atypical hemolytic-uremic syndrome with thrombomodulin anomaly\\\",\\n \\\"lymphoproliferative syndrome 1\\\",\\n \\\"purine nucleoside phosphorylase deficiency\\\",\\n \\\"spondylo-megaepiphyseal-metaphyseal dysplasia\\\",\\n \\\"brachydactylous dwarfism, Mseleni type\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Handigodu type\\\",\\n \\\"hemolytic anemia due to glucophosphate isomerase deficiency\\\",\\n \\\"alpha 1-antitrypsin deficiency\\\",\\n \\\"occult macular dystrophy\\\",\\n \\\"papillary thyroid carcinoma\\\",\\n \\\"periodontitis\\\",\\n \\\"polycystic ovary syndrome\\\",\\n \\\"polyp\\\",\\n \\\"preeclampsia\\\",\\n \\\"prostate adenocarcinoma\\\",\\n \\\"psoriasis\\\",\\n \\\"renal cell carcinoma\\\",\\n \\\"respiratory system disease\\\",\\n \\\"sarcoma\\\",\\n \\\"severe acute respiratory syndrome\\\",\\n \\\"Sjogren syndrome\\\",\\n \\\"skin disease\\\",\\n \\\"small cell lung carcinoma\\\",\\n \\\"rheumatoid arthritis\\\",\\n \\\"spindle cell tumor\\\",\\n \\\"spondyloarthropathy\\\",\\n \\\"squamous cell carcinoma\\\",\\n \\\"squamous cell lung carcinoma\\\",\\n \\\"systemic scleroderma\\\",\\n \\\"ulcerative colitis\\\",\\n \\\"uterine fibroid\\\",\\n \\\"melanoma\\\",\\n \\\"malignant peripheral nerve sheath tumor\\\",\\n \\\"viral disease\\\",\\n \\\"HIV infection\\\",\\n \\\"AIDS\\\",\\n \\\"idiopathic pulmonary fibrosis\\\",\\n \\\"malignant pleural mesothelioma\\\",\\n \\\"bacterial disease\\\",\\n \\\"temporal lobe epilepsy\\\",\\n \\\"myositis\\\",\\n \\\"leprosy\\\",\\n \\\"celiac disease\\\",\\n \\\"cervical carcinoma\\\",\\n \\\"cytomegalovirus infection\\\",\\n \\\"Down syndrome\\\",\\n \\\"endometriosis\\\",\\n \\\"experimental autoimmune encephalomyelitis\\\",\\n \\\"parasitic infection\\\",\\n \\\"lung carcinoma\\\",\\n \\\"ovarian carcinoma\\\",\\n \\\"post-traumatic stress disorder\\\",\\n \\\"pulmonary arterial hypertension\\\",\\n \\\"synovial sarcoma\\\",\\n \\\"autosomal dominant polycystic liver disease\\\",\\n \\\"cerebral creatine deficiency syndrome\\\",\\n \\\"arterial disorder\\\",\\n \\\"glomerulosclerosis\\\",\\n \\\"small intestinal neuroendocrine tumor G1\\\",\\n \\\"breast benign neoplasm\\\",\\n \\\"central nervous system primitive neuroectodermal neoplasm\\\",\\n \\\"vertebral column disorder\\\",\\n \\\"cerebral cavernous malformation\\\",\\n \\\"interstitial emphysema\\\",\\n \\\"gastric cancer\\\",\\n \\\"essential hypertension\\\",\\n \\\"hypertensive heart disease\\\",\\n \\\"familial hyperlipidemia\\\",\\n \\\"impaired renal function disease\\\",\\n \\\"myopia\\\",\\n \\\"nephrocalcinosis\\\",\\n \\\"leiomyoma\\\",\\n \\\"prolapse of female genital organ\\\",\\n \\\"brain cancer\\\",\\n \\\"nontoxic goiter\\\",\\n \\\"pure red-cell aplasia\\\",\\n \\\"crescentic glomerulonephritis\\\",\\n \\\"tuberous sclerosis\\\",\\n \\\"depressive disorder\\\",\\n \\\"ventricular septal defect\\\",\\n \\\"pneumothorax\\\",\\n \\\"Richter syndrome\\\",\\n \\\"thyroid cancer\\\",\\n \\\"giant cell tumor\\\",\\n \\\"spondylosis\\\",\\n \\\"papilloma\\\",\\n \\\"kidney cancer\\\",\\n \\\"dermatitis\\\",\\n \\\"prostatic adenoma\\\",\\n \\\"lobular neoplasia\\\",\\n \\\"gingival overgrowth\\\",\\n \\\"papillary adenocarcinoma\\\",\\n \\\"digestive system cancer\\\",\\n \\\"inherited lipid metabolism disorder\\\",\\n \\\"skin squamous cell carcinoma\\\",\\n \\\"teratocarcinoma\\\",\\n \\\"teratoma\\\",\\n \\\"bone inflammation disease\\\",\\n \\\"small cell osteogenic sarcoma\\\",\\n \\\"cerebral infarction\\\",\\n \\\"liver cancer\\\",\\n \\\"uterine cancer\\\",\\n \\\"anal canal adenocarcinoma\\\",\\n \\\"skin cancer\\\",\\n \\\"cerebellar neoplasm\\\",\\n \\\"cervical cancer\\\",\\n \\\"breast angiosarcoma\\\",\\n \\\"bile duct adenocarcinoma\\\",\\n \\\"thoracic cancer\\\",\\n \\\"colonic disorder\\\",\\n \\\"functioning pituitary gland adenoma\\\",\\n \\\"anal canal squamous cell carcinoma\\\",\\n \\\"pancreatic intraductal papillary-mucinous neoplasm\\\",\\n \\\"muscular atrophy\\\",\\n \\\"female breast carcinoma\\\",\\n \\\"retinal degeneration\\\",\\n \\\"MHC class II deficiency 4\\\",\\n \\\"immunodeficiency 122\\\",\\n \\\"inflammation\\\",\\n \\\"circulating fibrinogen levels\\\",\\n \\\"glomerular filtration rate\\\",\\n \\\"fat pad mass\\\",\\n \\\"hip circumference\\\",\\n \\\"bone tissue density\\\",\\n \\\"von Willebrand factor quality\\\",\\n \\\"waist circumference\\\",\\n \\\"age of onset of asthma\\\",\\n \\\"level of serum globulin type protein\\\",\\n \\\"red blood cell density\\\",\\n \\\"serum alanine aminotransferase amount\\\",\\n \\\"heart rate\\\",\\n \\\"age of onset of allergic disease\\\",\\n \\\"brain volume\\\",\\n \\\"serum albumin amount\\\",\\n \\\"serum creatinine amount\\\",\\n \\\"body height\\\",\\n \\\"cyst\\\",\\n \\\"X-linked hyper-IgM syndrome\\\",\\n \\\"Brachydactyly - elbow wrist dysplasia\\\",\\n \\\"Chronic mucocutaneous candidosis\\\",\\n \\\"Desbuquois syndrome\\\",\\n \\\"Chédiak-Higashi syndrome\\\",\\n \\\"Recurrent infection due to specific granule deficiency\\\",\\n \\\"Immunodeficiency syndrome with autoimmunity\\\",\\n \\\"Metaphyseal chondrodysplasia, Schmid type\\\",\\n \\\"Åland Islands eye disease\\\",\\n \\\"Ichthyosis - intellectual disability - dwarfism - renal impairment\\\",\\n \\\"Autosomal recessive early-onset inflammatory bowel disease\\\",\\n \\\"X-linked lymphoproliferative disease\\\",\\n \\\"Metaphyseal dysostosis - intellectual disability - conductive deafness\\\",\\n \\\"CHST3-related skeletal dysplasia\\\",\\n \\\"Cyclic neutropenia\\\",\\n \\\"Severe combined immunodeficiency due to adenosine deaminase deficiency\\\",\\n \\\"Aneurysm - osteoarthritis syndrome\\\",\\n \\\"Rare disease with thoracic aortic aneurysm and aortic dissection\\\",\\n \\\"Multiple osteochondromas\\\",\\n \\\"Recurrent infections-myelofibrosis-nephromegaly syndrome\\\",\\n \\\"Acromesomelic dysplasia, Maroteaux type\\\",\\n \\\"Hyperlipoproteinemia type 1\\\",\\n \\\"X-linked agammaglobulinemia\\\",\\n \\\"Familial hemophagocytic lymphohistiocytosis\\\",\\n \\\"Immunodeficiency by defective expression of HLA class 2\\\",\\n \\\"Pyogenic arthritis - pyoderma gangrenosum - acne\\\",\\n \\\"Familial adenomatous polyposis\\\",\\n \\\"Thymic aplasia\\\",\\n \\\"Other metabolic disease\\\",\\n \\\"Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification\\\",\\n \\\"Hypohidrotic ectodermal dysplasia with immunodeficiency\\\",\\n \\\"Leukocyte adhesion deficiency type III\\\",\\n \\\"hematocrit\\\",\\n \\\"C-reactive protein measurement\\\",\\n \\\"glucose measurement\\\",\\n \\\"hemoglobin measurement\\\",\\n \\\"bone quantitative ultrasound measurement\\\",\\n \\\"triglyceride measurement\\\",\\n \\\"alkaline phosphatase measurement\\\",\\n \\\"creatine kinase measurement\\\",\\n \\\"cryptorchidism\\\",\\n \\\"total cholesterol measurement\\\",\\n \\\"gestational diabetes\\\",\\n \\\"low density lipoprotein cholesterol measurement\\\",\\n \\\"lymphocyte count\\\",\\n \\\"acute lung injury\\\",\\n \\\"high density lipoprotein cholesterol measurement\\\",\\n \\\"osteoarthritis, knee\\\",\\n \\\"cystatin C measurement\\\",\\n \\\"factor VII measurement\\\",\\n \\\"IGF-1 measurement\\\",\\n \\\"factor VIII measurement\\\",\\n \\\"white matter integrity\\\",\\n \\\"hip geometry\\\",\\n \\\"factor XI measurement\\\",\\n \\\"intraocular pressure measurement\\\",\\n \\\"sex hormone-binding globulin measurement\\\",\\n \\\"age at menarche\\\",\\n \\\"pelvic organ prolapse\\\",\\n \\\"FEV/FVC ratio\\\",\\n \\\"prion disease\\\",\\n \\\"aspartate aminotransferase measurement\\\",\\n \\\"protein measurement\\\",\\n \\\"neutrophil count\\\",\\n \\\"eosinophil count\\\",\\n \\\"lymph node metastatic carcinoma\\\",\\n \\\"appendicular lean mass\\\",\\n \\\"lumbar disc degeneration\\\",\\n \\\"lean body mass\\\",\\n \\\"type 2 diabetes nephropathy\\\",\\n \\\"autoimmune disease\\\",\\n \\\"congenital heart disease\\\",\\n \\\"central corneal thickness\\\",\\n \\\"cholangiocarcinoma\\\",\\n \\\"reading\\\",\\n \\\"anxiety\\\",\\n \\\"primitive neuroectodermal tumor\\\",\\n \\\"aortic valve calcification\\\",\\n \\\"non-small cell lung adenocarcinoma\\\",\\n \\\"axial length measurement\\\",\\n \\\"contact dermatitis\\\",\\n \\\"vein disorder\\\",\\n \\\"in situ carcinoma\\\",\\n \\\"inborn disorder of amino acid metabolism\\\",\\n \\\"allergic asthma\\\",\\n \\\"fatty liver disease\\\",\\n \\\"alopecia\\\",\\n \\\"hypoplastic left heart syndrome\\\",\\n \\\"Alzheimer disease\\\",\\n \\\"asthma\\\",\\n \\\"urinary bladder carcinoma\\\",\\n \\\"cancer\\\",\\n \\\"glaucoma\\\",\\n \\\"schizophrenia\\\",\\n \\\"upper respiratory tract disorder\\\",\\n \\\"type 1 diabetes mellitus\\\",\\n \\\"type 2 diabetes mellitus\\\",\\n \\\"pulmonary hypertension\\\",\\n \\\"osteoarthritis\\\",\\n \\\"Parkinson disease\\\",\\n \\\"pancreatic ductal adenocarcinoma\\\",\\n \\\"bacterial urinary tract infection\\\",\\n \\\"allergic disease\\\",\\n \\\"multiple sclerosis\\\",\\n \\\"skin basal cell carcinoma\\\",\\n \\\"childhood onset asthma\\\",\\n \\\"colorectal cancer\\\",\\n \\\"Lynch syndrome\\\",\\n \\\"Wilms tumor\\\",\\n \\\"prune belly syndrome\\\",\\n \\\"Adams-Oliver syndrome\\\",\\n \\\"Acropectorovertebral dysplasia\\\",\\n \\\"severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency\\\",\\n \\\"Tietz syndrome\\\",\\n \\\"autosomal dominant Alport syndrome\\\",\\n \\\"Townes-Brocks syndrome\\\",\\n \\\"atelosteogenesis type III\\\",\\n \\\"Osebold-Remondini syndrome\\\",\\n \\\"brachydactyly type C\\\",\\n \\\"autosomal dominant brachyolmia\\\",\\n \\\"Gordon syndrome\\\",\\n \\\"breast cancer\\\",\\n \\\"chondrocalcinosis 2\\\",\\n \\\"congenital contractural arachnodactyly\\\",\\n \\\"fleck corneal dystrophy\\\",\\n \\\"Duane retraction syndrome\\\",\\n \\\"Leri-Weill dyschondrosteosis\\\",\\n \\\"Beckwith-Wiedemann syndrome\\\",\\n \\\"esophageal cancer\\\",\\n \\\"autoinflammatory syndrome, familial, X-linked, Behcet-like 2\\\",\\n \\\"immunodeficiency 98 with autoinflammation, X-linked\\\",\\n \\\"metastatic malignant neoplasm\\\",\\n \\\"granulomatous disease, chronic, autosomal recessive, 5\\\",\\n \\\"hyper-IgE recurrent infection syndrome 5, autosomal recessive\\\",\\n \\\"immunodeficiency 81\\\",\\n \\\"immunodeficiency 82 with systemic inflammation\\\",\\n \\\"inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive\\\",\\n \\\"immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias\\\",\\n \\\"immunodeficiency 75\\\",\\n \\\"immunodeficiency 76\\\",\\n \\\"nephrotic syndrome 16\\\",\\n \\\"immunodeficiency 69\\\",\\n \\\"immunodeficiency 78 with autoimmunity and developmental delay\\\",\\n \\\"immunodeficiency 70\\\",\\n \\\"immunodeficiency 72 with autoinflammation\\\",\\n \\\"immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia\\\",\\n \\\"autoinflammation, immune dysregulation, and eosinophilia\\\",\\n \\\"severe combined immunodeficiency due to CD70 deficiency\\\",\\n \\\"myofibroblastoma\\\",\\n \\\"invasive carcinoma\\\",\\n \\\"adenoviridae infectious disease\\\",\\n \\\"brain injury\\\",\\n \\\"nosocomial infection\\\",\\n \\\"enteritis\\\",\\n \\\"ulcer disease\\\",\\n \\\"radiation pneumonitis\\\",\\n \\\"familial adenomatous polyposis 4\\\",\\n \\\"severe combined immunodeficiency due to LAT deficiency\\\",\\n \\\"desmoplastic melanoma\\\",\\n \\\"myelofibrosis\\\",\\n \\\"salivary duct carcinoma\\\",\\n \\\"oral cavity carcinoma\\\",\\n \\\"rectal carcinoma\\\",\\n \\\"vertebral disorder\\\",\\n \\\"digestive system melanoma\\\",\\n \\\"short-rib thoracic dysplasia 17 with or without polydactyly\\\",\\n \\\"platelet abnormalities with eosinophilia and immune-mediated inflammatory disease\\\",\\n \\\"COVID-19\\\",\\n \\\"liver failure\\\",\\n \\\"COVID-19–associated multisystem inflammatory syndrome in adults\\\",\\n \\\"disease arising from reactivation of latent virus\\\",\\n \\\"Friedreich ataxia\\\",\\n \\\"malignant glioma\\\",\\n \\\"spondyloepimetaphyseal dysplasia\\\",\\n \\\"gastrointestinal defects and immunodeficiency syndrome 1\\\",\\n \\\"immunodeficiency 105\\\",\\n \\\"autoinflammatory disease, X-linked\\\",\\n \\\"autoinflammatory syndrome with immunodeficiency\\\",\\n \\\"achalasia-alacrima syndrome\\\",\\n \\\"choroidal neovascularization\\\",\\n \\\"rhizomelic dysplasia, Ain-Naz type\\\",\\n \\\"autoinflammatory disease, multisystem, with immune dysregulation, X-linked\\\",\\n \\\"hyper-IgE syndrome 6, autosomal dominant, with recurrent infections\\\",\\n \\\"immunodeficiency 113 with autoimmunity and autoinflammation\\\",\\n \\\"immunodeficiency 117\\\",\\n \\\"neutropenia, severe congenital, 11, autosomal dominant\\\",\\n \\\"autoinflammation with episodic fever and immune dysregulation\\\",\\n \\\"immunodeficiency 119\\\",\\n \\\"postmenopausal osteoporosis\\\",\\n \\\"dissection\\\",\\n \\\"uterine neoplasm\\\",\\n \\\"pancreatic neoplasm\\\",\\n \\\"kidney neoplasm\\\",\\n \\\"brain aneurysm\\\",\\n \\\"colitis\\\",\\n \\\"osteoporosis\\\",\\n \\\"chronic kidney disease\\\",\\n \\\"ovarian neoplasm\\\",\\n \\\"acne\\\",\\n \\\"ankylosing spondylitis\\\",\\n \\\"deep vein thrombosis\\\",\\n \\\"angina pectoris\\\",\\n \\\"atherosclerosis\\\",\\n \\\"necrotizing enterocolitis\\\",\\n \\\"gastroesophageal reflux disease\\\",\\n \\\"seasonal allergic rhinitis\\\",\\n \\\"breast neoplasm\\\",\\n \\\"left ventricular hypertrophy\\\",\\n \\\"stomach neoplasm\\\",\\n \\\"obstructive sleep apnea\\\",\\n \\\"relapsing-remitting multiple sclerosis\\\",\\n \\\"angiosarcoma\\\",\\n \\\"colorectal neoplasm\\\",\\n \\\"neuropathy\\\",\\n \\\"open-angle glaucoma\\\",\\n \\\"basal cell carcinoma\\\",\\n \\\"IGA glomerulonephritis\\\",\\n \\\"hepatitis B virus infection\\\",\\n \\\"skin neoplasm\\\",\\n \\\"Vitiligo\\\",\\n \\\"hypospadias\\\",\\n \\\"Keloid\\\",\\n \\\"Abdominal Aortic Aneurysm\\\",\\n \\\"chronic hepatitis C virus infection\\\",\\n \\\"eosinophilic esophagitis\\\",\\n \\\"exfoliation syndrome\\\",\\n \\\"focal segmental glomerulosclerosis\\\",\\n \\\"chronic hepatitis B virus infection\\\",\\n \\\"interstitial lung disease\\\",\\n \\\"mucocutaneous lymph node syndrome\\\",\\n \\\"meningococcal infection\\\",\\n \\\"membranous glomerulonephritis\\\",\\n \\\"nephrotic syndrome\\\",\\n \\\"osteonecrosis\\\",\\n \\\"bone disease\\\",\\n \\\"vascular disease\\\",\\n \\\"peripheral arterial disease\\\",\\n \\\"sclerosing cholangitis\\\",\\n \\\"scoliosis\\\",\\n \\\"brain infarction\\\",\\n \\\"thoracic aortic aneurysm\\\",\\n \\\"ventricular fibrillation\\\",\\n \\\"colonic neoplasm\\\",\\n \\\"erythrocyte count\\\",\\n \\\"platelet count\\\",\\n \\\"vital capacity\\\",\\n \\\"forced expiratory volume\\\",\\n \\\"smoking behavior\\\",\\n \\\"body weight\\\",\\n \\\"body mass index\\\",\\n \\\"body fat distribution\\\",\\n \\\"waist-hip ratio\\\",\\n \\\"corneal topography\\\",\\n \\\"neuroimaging measurement\\\",\\n \\\"metastatic neoplasm\\\",\\n \\\"wheezing\\\",\\n \\\"enthesitis-related juvenile idiopathic arthritis\\\",\\n \\\"Chronic Obstructive Asthma\\\",\\n \\\"carotid atherosclerosis\\\",\\n \\\"pulse wave reflection index measurement\\\",\\n \\\"total hip arthroplasty\\\",\\n \\\"kidney injury\\\",\\n \\\"muscle atrophy\\\",\\n \\\"chromosomal aberration frequency\\\",\\n \\\"bone metastasis\\\",\\n \\\"HMG CoA reductase inhibitor use measurement\\\",\\n \\\"Inhalant adrenergic use measurement\\\",\\n \\\"Glucocorticoid use measurement\\\",\\n \\\"low density lipoprotein triglyceride measurement\\\",\\n \\\"diverticular disease\\\",\\n \\\"corneal resistance factor\\\",\\n \\\"citrate measurement\\\",\\n \\\"cholesteryl ester measurement\\\",\\n \\\"glucuronate measurement\\\",\\n \\\"isocitrate measurement\\\",\\n \\\"atopic asthma\\\",\\n \\\"coinfection\\\",\\n \\\"total joint arthroplasty\\\",\\n \\\"aspartate aminotransferase to alanine aminotransferase ratio\\\",\\n \\\"nephrotoxicity\\\",\\n \\\"inflammatory bowel disease, immunodeficiency, and encephalopathy\\\",\\n \\\"severe malarial anemia\\\",\\n \\\"total knee arthroplasty\\\",\\n \\\"palmitate 16:0 measurement\\\",\\n \\\"sexual dimorphism measurement\\\",\\n \\\"body surface area\\\",\\n \\\"serum lipopolysaccharide activity\\\",\\n \\\"Birt-Hogg-Dube syndrome\\\",\\n \\\"25-hydroxyvitamin D3 measurement\\\",\\n \\\"cecum adenocarcinoma\\\",\\n \\\"chronic rhinosinusitis\\\",\\n \\\"cystitis\\\",\\n \\\"granulosa cell tumor\\\",\\n \\\"ovarian clear cell adenocarcinoma\\\",\\n \\\"pancreatic adenocarcinoma\\\",\\n \\\"pancreatic neuroendocrine tumor\\\",\\n \\\"pulmonary tuberculosis\\\",\\n \\\"tongue squamous cell carcinoma\\\",\\n \\\"nasopharyngeal squamous cell carcinoma\\\",\\n \\\"Acute Leukemia\\\",\\n \\\"Ampulla of Vater Carcinoma\\\",\\n \\\"Appendix Adenocarcinoma\\\",\\n \\\"Atrophy\\\",\\n \\\"Atypical Meningioma\\\",\\n \\\"Bladder Small Cell Neuroendocrine Carcinoma\\\",\\n \\\"Cavernous Hemangioma\\\",\\n \\\"Central Nervous System Lymphoma\\\",\\n \\\"Cervical Adenosquamous Carcinoma\\\",\\n \\\"cervical squamous cell carcinoma\\\",\\n \\\"Colon Dysplasia\\\",\\n \\\"Duodenal Adenocarcinoma\\\",\\n \\\"Endometrial Clear Cell Adenocarcinoma\\\",\\n \\\"Endometrial Endometrioid Adenocarcinoma\\\",\\n \\\"Endometrial Undifferentiated Carcinoma\\\",\\n \\\"Fibroblastic Neoplasm\\\",\\n \\\"hereditary diffuse gastric adenocarcinoma\\\",\\n \\\"Holt-Oram syndrome\\\",\\n \\\"Huntington disease\\\",\\n \\\"nonpapillary renal cell carcinoma\\\",\\n \\\"Pallister-Hall syndrome\\\",\\n \\\"periodic fever, immunodeficiency, and thrombocytopenia syndrome\\\",\\n \\\"platyspondylic dysplasia, Torrance type\\\",\\n \\\"systemic lupus erythematosus\\\",\\n \\\"Marfan syndrome\\\",\\n \\\"melorheostosis\\\",\\n \\\"mesomelic dysplasia, Kantaputra type\\\",\\n \\\"metatropic dysplasia\\\",\\n \\\"Mobius syndrome\\\",\\n \\\"Muir-Torre syndrome\\\",\\n \\\"Cowden syndrome 1\\\",\\n \\\"myotonic dystrophy type 1\\\",\\n \\\"nail-patella syndrome\\\",\\n \\\"autosomal dominant progressive nephropathy with hypertension\\\",\\n \\\"ovarian cancer\\\",\\n \\\"Peyronie disease\\\",\\n \\\"polyostotic fibrous dysplasia\\\",\\n \\\"juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome\\\",\\n \\\"Hutchinson-Gilford progeria syndrome\\\",\\n \\\"familial juvenile hyperuricemic nephropathy type 1\\\",\\n \\\"Peutz-Jeghers syndrome\\\",\\n \\\"prostate cancer\\\",\\n \\\"pseudoachondroplasia\\\",\\n \\\"autosomal dominant distal renal tubular acidosis\\\",\\n \\\"retinoblastoma\\\",\\n \\\"Smith-Magenis syndrome\\\",\\n \\\"spondyloepiphyseal dysplasia tarda, autosomal dominant\\\",\\n \\\"spondyloepimetaphyseal dysplasia, Strudwick type\\\",\\n \\\"spondylometaphyseal dysplasia, Kozlowski type\\\",\\n \\\"spondylometaphyseal dysplasia, Schmidt type\\\",\\n \\\"proximal symphalangism\\\",\\n \\\"syndactyly type 5\\\",\\n \\\"brachydactyly-elbow wrist dysplasia syndrome\\\",\\n \\\"tarsal-carpal coalition syndrome\\\",\\n \\\"thoracolaryngopelvic dysplasia\\\",\\n \\\"tooth and nail syndrome\\\",\\n \\\"volvulus of midgut\\\",\\n \\\"short-limb skeletal dysplasia with severe combined immunodeficiency\\\",\\n \\\"acrocallosal syndrome\\\",\\n \\\"acrodermatitis enteropathica\\\",\\n \\\"acromesomelic dysplasia 2C, Hunter-Thompson type\\\",\\n \\\"agnathia-otocephaly complex\\\",\\n \\\"autosomal recessive Alport syndrome\\\",\\n \\\"amelogenesis imperfecta type 1G\\\",\\n \\\"microphthalmia with limb anomalies\\\",\\n \\\"progressive pseudorheumatoid arthropathy of childhood\\\",\\n \\\"Bloom syndrome\\\",\\n \\\"kyphomelic dysplasia\\\",\\n \\\"lung cancer\\\",\\n \\\"heart defects-limb shortening syndrome\\\",\\n \\\"chordoma\\\",\\n \\\"Juberg-Hayward syndrome\\\",\\n \\\"Costello syndrome\\\",\\n \\\"cystic fibrosis\\\",\\n \\\"hereditary renal hypouricemia\\\",\\n \\\"diastrophic dysplasia\\\",\\n \\\"Dyggve-Melchior-Clausen disease\\\",\\n \\\"Ehlers-Danlos syndrome, dermatosparaxis type\\\",\\n \\\"multiple epiphyseal dysplasia type 4\\\",\\n \\\"classic Hodgkin lymphoma\\\",\\n \\\"immunodeficiency, common variable, 2\\\",\\n \\\"ichthyosis-intellectual disability-dwarfism-renal impairment syndrome\\\",\\n \\\"Nezelof syndrome\\\",\\n \\\"spondylometaphyseal dysplasia, Sedaghatian type\\\",\\n \\\"metaphyseal dysostosis-intellectual disability-conductive deafness syndrome\\\",\\n \\\"Nijmegen breakage syndrome\\\",\\n \\\"Miyoshi myopathy\\\",\\n \\\"carnitine palmitoyl transferase II deficiency, myopathic form\\\",\\n \\\"Schwartz-Jampel syndrome\\\",\\n \\\"Leigh syndrome\\\",\\n \\\"nail-patella-like renal disease\\\",\\n \\\"nephronophthisis 1\\\",\\n \\\"congenital nephrotic syndrome, Finnish type\\\",\\n \\\"multiple myeloma\\\",\\n \\\"cervical adenocarcinoma\\\",\\n \\\"liver disease\\\",\\n \\\"cirrhosis of liver\\\",\\n \\\"lymphoid neoplasm\\\",\\n \\\"coronary artery disease\\\",\\n \\\"prostate carcinoma\\\",\\n \\\"aortic aneurysm\\\",\\n \\\"human papilloma virus infection\\\",\\n \\\"fibrosarcoma\\\",\\n \\\"benign neoplasm\\\",\\n \\\"hypertrophy\\\",\\n \\\"anaplastic astrocytoma\\\",\\n \\\"cardiac hypertrophy\\\",\\n \\\"medical procedure\\\",\\n \\\"AIDS dementia\\\",\\n \\\"juvenile idiopathic arthritis\\\",\\n \\\"insulin resistance\\\",\\n \\\"prostate intraepithelial neoplasia\\\",\\n \\\"septic peritonitis\\\",\\n \\\"vulvar intraepithelial neoplasia\\\",\\n \\\"renal carcinoma\\\",\\n \\\"thyroid carcinoma\\\",\\n \\\"metastatic melanoma\\\",\\n \\\"pancreatic carcinoma\\\",\\n \\\"rotavirus infection\\\",\\n \\\"Cutaneous T-cell lymphoma\\\",\\n \\\"ovarian serous adenocarcinoma\\\",\\n \\\"rhabdomyosarcoma\\\",\\n \\\"medulloblastoma\\\",\\n \\\"muscular disease\\\",\\n \\\"transitional cell carcinoma of kidney\\\",\\n \\\"anaplastic large cell lymphoma\\\",\\n \\\"bacteriemia\\\",\\n \\\"hepatitis C virus infection\\\",\\n \\\"non-small cell lung carcinoma\\\",\\n \\\"kidney disease\\\",\\n \\\"non-alcoholic fatty liver disease\\\",\\n \\\"peripheral neuropathy\\\",\\n \\\"testicular seminoma\\\",\\n \\\"pneumonia\\\",\\n \\\"heart failure\\\",\\n \\\"vitamin D deficiency\\\",\\n \\\"inflammatory bowel disease\\\",\\n \\\"diabetic retinopathy\\\",\\n \\\"heart disease\\\",\\n \\\"psoriatic arthritis\\\",\\n \\\"refractory anemia with ringed sideroblasts\\\",\\n \\\"laryngeal neoplasm\\\",\\n \\\"lung disease\\\",\\n \\\"brain neoplasm\\\",\\n \\\"calcification\\\",\\n \\\"retinopathy\\\",\\n \\\"thyroid neoplasm\\\"\\n ],\\n \\\"tissue_specific_expression\\\": {\\n \\\"breast\\\": 0,\\n \\\"atrium auricular region\\\": 1,\\n \\\"liver\\\": 0,\\n \\\"skeletal muscle tissue\\\": 1,\\n \\\"EBV-transformed lymphocyte\\\": 0,\\n \\\"esophagus mucosa\\\": 1,\\n \\\"macrophage\\\": -1,\\n \\\"adipose tissue\\\": 0,\\n \\\"segmented neutrophil of bone marrow\\\": -1,\\n \\\"CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\": -1,\\n \\\"class switched memory B cell\\\": 0,\\n \\\"CD14-positive, CD16-negative classical monocyte\\\": 3,\\n \\\"Brodmann (1909) area 9\\\": 0,\\n \\\"CD4-positive, alpha-beta thymocyte\\\": 1,\\n \\\"zone of skin\\\": 1,\\n \\\"leukocyte\\\": 0,\\n \\\"nasopharynx\\\": -1,\\n \\\"tonsil\\\": 0,\\n \\\"frontal lobe\\\": 0,\\n \\\"cerebellar hemisphere\\\": -1,\\n \\\"putamen\\\": 0,\\n \\\"hematopoietic stem cell\\\": -1,\\n \\\"effector memory CD4-positive, alpha-beta T cell\\\": 0,\\n \\\"testis\\\": -1,\\n \\\"bronchus\\\": -1,\\n \\\"sigmoid colon\\\": 0,\\n \\\"fallopian tube\\\": 0,\\n \\\"plasma cell\\\": -1,\\n \\\"aorta\\\": 0,\\n \\\"adrenal gland\\\": -1,\\n \\\"kidney\\\": 0,\\n \\\"endometrium\\\": 0,\\n \\\"smooth muscle tissue\\\": 0,\\n \\\"tibial artery\\\": 0,\\n \\\"prefrontal cortex\\\": 0,\\n \\\"CD8-positive, alpha-beta T cell\\\": -1,\\n \\\"vermiform appendix\\\": 0,\\n \\\"lymph node\\\": 0,\\n \\\"duodenum\\\": 0,\\n \\\"mature eosinophil\\\": 0,\\n \\\"prostate gland\\\": 1,\\n \\\"C1 segment of cervical spinal cord\\\": -1,\\n \\\"lung\\\": 0,\\n \\\"inflammatory macrophage\\\": -1,\\n \\\"rectum\\\": 0,\\n \\\"suprapubic skin\\\": 0,\\n \\\"brain\\\": -1,\\n \\\"coronary artery\\\": 0,\\n \\\"parathyroid gland\\\": -1,\\n \\\"Brodmann (1909) area 24\\\": 0,\\n \\\"esophagus muscularis mucosa\\\": 0,\\n \\\"esophagus\\\": 1,\\n \\\"transformed skin fibroblast\\\": 1,\\n \\\"heart muscle\\\": -1,\\n \\\"pancreas\\\": 0,\\n \\\"uterus\\\": 0,\\n \\\"placenta\\\": 0,\\n \\\"seminal vesicle\\\": -1,\\n \\\"hippocampus\\\": -1,\\n \\\"effector memory CD8-positive, alpha-beta T cell\\\": 0,\\n \\\"endothelial cell of umbilical vein (resting)\\\": 0,\\n \\\"minor salivary gland\\\": 0,\\n \\\"endocervix\\\": 1,\\n \\\"central memory CD8-positive, alpha-beta T cell\\\": 0,\\n \\\"CD8-positive, alpha-beta thymocyte\\\": -1,\\n \\\"granulocyte monocyte progenitor cell\\\": -1,\\n \\\"caudate nucleus\\\": 0,\\n \\\"amygdala\\\": 0,\\n \\\"temporal lobe\\\": 0,\\n \\\"substantia nigra\\\": -1,\\n \\\"abdomen\\\": -1,\\n \\\"common lymphoid progenitor\\\": 0,\\n \\\"cerebral cortex\\\": 0,\\n \\\"endothelial cell of umbilical vein (proliferating)\\\": 0,\\n \\\"blood\\\": -1,\\n \\\"nucleus accumbens\\\": 0,\\n \\\"stomach\\\": 0,\\n \\\"oral mucosa\\\": -1,\\n \\\"mature neutrophil\\\": 0,\\n \\\"central memory CD4-positive, alpha-beta T cell\\\": 0,\\n \\\"bone marrow\\\": -1,\\n \\\"gall bladder\\\": 1,\\n \\\"colon\\\": 0,\\n \\\"cytotoxic CD56-dim natural killer cell\\\": -1,\\n \\\"pituitary gland\\\": 0,\\n \\\"transverse colon\\\": 0,\\n \\\"heart left ventricle\\\": 0,\\n \\\"erythroblast\\\": -1,\\n \\\"vagina\\\": 1,\\n \\\"ovary\\\": 1,\\n \\\"megakaryocyte-erythroid progenitor cell\\\": -1,\\n \\\"subcutaneous adipose tissue\\\": 1,\\n \\\"cerebellum\\\": -1,\\n \\\"hypothalamus\\\": -1,\\n \\\"common myeloid progenitor\\\": -1,\\n \\\"hematopoietic multipotent progenitor cell\\\": -1,\\n \\\"alternatively activated macrophage\\\": -1,\\n \\\"thyroid gland\\\": 1,\\n \\\"lower leg skin\\\": 0,\\n \\\"epididymis\\\": -1,\\n \\\"spleen\\\": 0,\\n \\\"esophagogastric junction\\\": 0,\\n \\\"greater omentum\\\": 1,\\n \\\"memory B cell\\\": 0,\\n \\\"hippocampus proper\\\": -1,\\n \\\"CD4-positive, alpha-beta T cell\\\": -1,\\n \\\"small intestine\\\": 1,\\n \\\"conventional dendritic cell\\\": -1,\\n \\\"cortex of kidney\\\": 0,\\n \\\"small intestine Peyer's patch\\\": 0,\\n \\\"heart\\\": -1,\\n \\\"CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\": -1,\\n \\\"caudate-putamen\\\": -1,\\n \\\"urinary bladder\\\": 1,\\n \\\"ectocervix\\\": 1,\\n \\\"regulatory T cell\\\": -1,\\n \\\"CD38-negative naive B cell\\\": 1,\\n \\\"saliva-secreting gland\\\": 0,\\n \\\"neutrophilic metamyelocyte\\\": -1,\\n \\\"tibial nerve\\\": 0\\n },\\n \\\"is_essential\\\": false,\\n \\\"genetic_constraint\\\": {\\n \\\"syn\\\": -0.12650999426841736,\\n \\\"mis\\\": 4.360300064086914,\\n \\\"lof\\\": 0.9999799728393555\\n },\\n \\\"pharmacovigilance\\\": []\\n },\\n \\\"transcriptome\\\": {\\n \\\"transcripts\\\": {},\\n \\\"isoforms\\\": {\\n \\\"general_localization\\\": {\\n \\\"name\\\": \\\"general_localization\\\",\\n \\\"aliases\\\": [],\\n \\\"status\\\": null,\\n \\\"locations\\\": [\\n \\\"Cytoplasm\\\",\\n \\\"Nucleus\\\"\\n ],\\n \\\"notes\\\": [\\n \\\"Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)\\\"\\n ]\\n }\\n },\\n \\\"avg_exons_per_transcript\\\": null,\\n \\\"transcript_count\\\": 0,\\n \\\"total_exon_count\\\": null,\\n \\\"median_transcript_span_bp\\\": null,\\n \\\"max_transcript_span_bp\\\": null\\n },\\n \\\"gwas_profile\\\": null,\\n \\\"variants\\\": {},\\n \\\"traits\\\": [],\\n \\\"binding_peaks\\\": {},\\n \\\"mirna_targets\\\": {},\\n \\\"alliancegenome_info\\\": [],\\n \\\"viral_interactions\\\": [],\\n \\\"text_summaries_from_tools\\\": [\\n \\\"*Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0\\\",\\n \\\"*Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.\\\",\\n \\\"*ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00\\\",\\n \\\"*ChEMBL: Interpretation Notes\\\\n- Bioactivity values are normalized to nM and aggregated per compound.\\\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\\\n- Reported values are the lowest (strongest) potency observed per assay type.\\\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\\\n- InChIKeys are provided for PubChem enrichment.\\\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\\\n- Schema version = 35.0 (local snapshot).\\\\n- These summaries are heuristic and not a substitute for experimental validation.\\\",\\n \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\\",\\n \\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.\\\",\\n \\\"*OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555\\\",\\n \\\"*GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\\\"\\n ],\\n \\\"tools_run\\\": [\\n \\\"EntityExtraction\\\",\\n \\\"MSigDB\\\",\\n \\\"uniprot_entry\\\",\\n \\\"BioGRID\\\",\\n \\\"OpenTargets\\\",\\n \\\"reactome_pathways\\\",\\n \\\"humanbase_predictions\\\"\\n ]\\n}\"],[\"20251224-191245_ui/genes/SMAD3/summary.txt\",\"• Symbol: SMAD3 | Entrez: 4088 | UniProt: P84022\\n• Transcripts: n_transcripts=0:\\n• Pathways: Cytokine Signaling in Immune system; Interleukin-1 family signaling; SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Viral Infection Pathways; Signaling by TGFBR3; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Signaling by Interleukins; Deubiquitination; Signaling by NOTCH; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; RUNX3 regulates CDKN1A transcription; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; TGFBR3 expression; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; SARS-CoV-1-host interactions; FOXO-mediated transcription; Infectious disease; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; SARS-CoV Infections; Formation of axial mesoderm; SARS-CoV-1 Infection; Germ layer formation at gastrulation; Signaling by NOTCH4; Downregulation of TGF-beta receptor signaling; Interleukin-37 signaling; Formation of definitive endoderm; RUNX3 regulates BCL2L11 (BIM) transcription; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Immune System; SMAD2/3 MH2 Domain Mutants in Cancer; Transcriptional regulation by RUNX3; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL\\n• GO: C:SMAD protein complex; C:chromatin; C:ciliary basal body; C:cytoplasm; C:cytosol; C:heteromeric SMAD protein complex; C:intracellular membrane-bounded organelle; C:nuclear inner membrane; C:nucleoplasm; C:nucleus; C:plasma membrane; C:receptor complex; C:transcription regulator complex; F:DEAD/H-box RNA helicase binding; F:DNA binding; F:DNA-binding transcription activator activity, RNA polymerase II-specific; F:DNA-binding transcription factor activity; F:DNA-binding transcription factor activity, RNA polymerase II-specific; F:DNA-binding transcription factor binding; F:DNA-binding transcription repressor activity; F:I-SMAD binding; F:R-SMAD binding; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; F:RNA polymerase II-specific DNA-binding transcription factor binding; F:bHLH transcription factor binding; F:beta-catenin binding; F:chromatin DNA binding; F:cis-regulatory region sequence-specific DNA binding; F:co-SMAD binding; F:collagen binding; F:identical protein binding; F:nuclear glucocorticoid receptor binding; F:nuclear mineralocorticoid receptor binding; F:nuclear receptor binding; F:phosphatase binding; F:promoter-specific chromatin binding; F:protein homodimerization activity; F:protein kinase binding; F:sequence-specific DNA binding; F:sterol response element binding; F:transcription cis-regulatory region binding; F:transcription coactivator binding; F:transcription corepressor binding; F:transforming growth factor beta receptor binding; F:ubiquitin binding; F:ubiquitin protein ligase binding; F:zinc ion binding; P:JNK cascade; P:SMAD protein signal transduction; P:T cell activation; P:activin receptor signaling pathway; P:adrenal gland development; P:anatomical structure morphogenesis; P:apoptotic signaling pathway; P:cell differentiation; P:cell population proliferation; P:cell-cell junction organization; P:cellular response to glucose stimulus; P:cellular response to transforming growth factor beta stimulus; P:cellular response to virus; P:developmental growth; P:embryonic cranial skeleton morphogenesis; P:embryonic foregut morphogenesis; P:embryonic pattern specification; P:endoderm development; P:extrinsic apoptotic signaling pathway; P:heart looping; P:immune response; P:immune system development; P:in utero embryonic development; P:lens fiber cell differentiation; P:liver development; P:mesoderm formation; P:negative regulation of apoptotic process; P:negative regulation of cardiac muscle hypertrophy in response to stress; P:negative regulation of cell differentiation; P:negative regulation of cell growth; P:negative regulation of cell population proliferation; P:negative regulation of cytosolic calcium ion concentration; P:negative regulation of fat cell differentiation; P:negative regulation of gene expression; P:negative regulation of inflammatory response; P:negative regulation of lung blood pressure; P:negative regulation of miRNA transcription; P:negative regulation of ossification; P:negative regulation of osteoblast differentiation; P:negative regulation of osteoblast proliferation; P:negative regulation of protein catabolic process; P:negative regulation of transcription by RNA polymerase II; P:negative regulation of wound healing; P:nodal signaling pathway; P:osteoblast development; P:paraxial mesoderm morphogenesis; P:pericardium development; P:positive regulation of DNA-templated transcription; P:positive regulation of SMAD protein signal transduction; P:positive regulation of bone mineralization; P:positive regulation of canonical Wnt signaling pathway; P:positive regulation of cell migration; P:positive regulation of chondrocyte differentiation; P:positive regulation of epithelial to mesenchymal transition; P:positive regulation of extracellular matrix assembly; P:positive regulation of focal adhesion assembly; P:positive regulation of gene expression; P:positive regulation of interleukin-1 beta production; P:positive regulation of miRNA transcription; P:positive regulation of nitric oxide biosynthetic process; P:positive regulation of positive chemotaxis; P:positive regulation of protein import into nucleus; P:positive regulation of stress fiber assembly; P:positive regulation of transcription by RNA polymerase II; P:positive regulation of transforming growth factor beta3 production; P:primary miRNA processing; P:protein stabilization; P:regulation of DNA-templated transcription; P:regulation of epithelial cell proliferation; P:regulation of immune response; P:regulation of miRNA transcription; P:regulation of mitochondrial membrane potential; P:regulation of striated muscle tissue development; P:regulation of transcription by RNA polymerase II; P:regulation of transforming growth factor beta receptor signaling pathway; P:regulation of transforming growth factor beta2 production; P:release of cytochrome c from mitochondria; P:response to angiotensin; P:response to hypoxia; P:signal transduction involved in regulation of gene expression; P:somitogenesis; P:thyroid gland development; P:transdifferentiation; P:transforming growth factor beta receptor signaling pathway; P:trophoblast cell migration; P:ureteric bud development; P:wound healing\\n• Interactions from human data (Affinity Capture-Luminescence): BAG3, HIF1A, SMAD2, SMAD4, SMURF1, SMURF2, SP1\\n• Interactions from human data (Affinity Capture-MS): ARID1A, ATG14, ATG16L1, ATXN2L, BUB3, C1ORF116, CD6, CDK11A, CHD8, CIC, CREBBP, CSNK1D, CTNNB1, DCAF4, DCAF7, DDX3X, DDX3Y, DDX4, DHX8, DNAJA2, DOCK9, DYRK1A, DZIP3, EPB41L5, ERBB2IP, EVA1B, EZH2, FAM83G, FURIN, HINT3, HSPA4, IRF7, IRS1, ITGB4, KAT6A, KCTD16, LACRT, LDLRAD4, LEMD3, LRCH1, LSR, MAP2K3, MAPK1, MED16, MED4, NCOA3, NF2, OPA1, OTUB1, OTUD1, PABPC1, PARK2, PJA1, PLEKHA4, PPIE, PRNP, PSPC1, PTPN6, RAB11FIP5, RPL3, RPL4, RPSAP15, SIK3, SLC25A12, SLC9A3R2, SMAD1, SMAD2, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMURF2, SNW1, SQRDL, SUZ12, TAF1, TAF2, TCP1, TGFB1, TMEM192, TRIM33, TRIM67, TRIP4, U2AF2, UGT1A10, USP33, USP7, VAV2, WWP2, YTHDF2, YY1, ZFP69B, ZFYVE9, ZRANB1\\n• Interactions from human data (Affinity Capture-RNA): DDX58, TRIM25\\n• Interactions from human data (Affinity Capture-Western): ACTB, ACVR1B, AKT1, ANAPC10, AR, ATF2, ATF3, BACH1, BRCA1, BRCA2, BTRC, CBL, CDC16, CDC25A, CDC27, CDKN1A, CEBPD, CHRD, CHUK, CITED2, CREBBP, CSNK1D, CSNK1G2, CTCF, CTNNB1, CUL1, DAB2, DACH1, DEDD, DOCK9, E2F4, EID2, ELAC2, EP300, ERBB2IP, ESR1, EZH2, FHL1, FHL2, FHL3, FOS, FOXH1, FOXL2, FOXM1, FOXO1, FOXO3, FOXO4, GRIP1, GSK3B, HDAC4, HDAC5, HGS, HIF1A, HNF4A, HYAL2, ID1, IRF7, JUN, KAT2A, KAT2B, KAT6A, KDM5C, KDM6B, KLF5, KPNB1, LEF1, MAFK, MECOM, MED15, MED24, MED6, MEN1, METTL14, METTL3, MKL1, MYC, MYD88, MYOCD, NCOA1, NEDD4, NEDD4L, NEDD9, NFIC, NFYC, NOTCH1, NOTCH4, NR3C1, NR4A1, NUP214, OTUB1, OTUD1, OVOL2, PAX6, PCK2, PDLIM5, PIAS3, PIAS4, PIN1, PITX1, PITX2, PML, PPARG, PPP1R12C, PRDM16, PRTN3, RARA, RBBP5, RBL1, RBX1, RELB, RGCC, RNF111, RNF31, RUNX1, RUNX2, RUNX3, S100A4, SETD2, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD7, SMARCA4, SMARCC2, SMURF1, SMURF2, SOX9, SP1, SPTBN1, SQSTM1, SREBF2, SRY, STRAP, STUB1, SUV39H1, TCF12, TGFB1I1, TGFBR1, TGFBR2, TGIF1, TGIF2, TOB1, TP53, TRIB3, TRIM24, TRIM33, TRIM62, TSC2, TSC22D4, UCHL1, UCHL5, USP15, USP2, USP7, USP9X, WWOX, WWP1, WWP2, YAP1, ZC3H12A, ZEB1, ZEB2, ZFYVE9, ZMIZ1\\n• Interactions from human data (Biochemical Activity): CDK2, CDK4, CDK8, CDK9, CSNK1D, CSNK1G2, MAPK1, NEDD4, NEDD4L, OTUB1, TGFBR1, USP15, USP7, WWP2\\n• Interactions from human data (Co-crystal Structure): SMAD3, SMAD4, ZFYVE9\\n• Interactions from human data (Co-fractionation): ALKBH2, ANAPC10, APP, ARID1B, CDH1, CREBBP, CTCF, CTNNB1, CUL1, DDR1, FOXO3, HDAC1, HMGA2, IGF1R, ITGB1, JUND, MTA2, NAA15, NT5DC3, PARP1, PRKDC, RBM14, RBX1, RELA, RIPK1, RNMT, SIN3A, SKP1, SMAD2, SMARCA4, SMARCC1, SMARCC2, SNF8, SP1, SUB1, TRIM33, XRCC5, XRCC6, ZFHX3, ZFYVE9\\n• Interactions from human data (Co-localization): AKT1, BMP7, CAMK2G, CDK2, CDK4, EPAS1, ETS1, FOXO3, HIF1A, IRF7, MAP3K7, MAPK8, MAX, TP53, TRIM62\\n• Interactions from human data (Cross-Linking-MS (XL-MS)): RPL10A\\n• Interactions from human data (FRET): SMAD4, STUB1\\n• Interactions from human data (PCA): SMAD4, SMAD7\\n• Interactions from human data (Phenotypic Enhancement): HIF1A, SMAD2, SNW1\\n• Interactions from human data (Phenotypic Suppression): SMAD7, STRAP\\n• Interactions from human data (Positive Genetic): JAK1\\n• Interactions from human data (Protein-RNA): LINC00941\\n• Interactions from human data (Protein-peptide): CREBBP, FOXH1, ITCH, LEF1, NEDD4, PIN1\\n• Interactions from human data (Proximity Label-MS): NFIA\\n• Interactions from human data (Reconstituted Complex): ANAPC10, APP, AR, ATF2, ATF3, BPTF, BRCA1, BRCA2, CEBPA, CEBPB, CEBPD, CITED2, CREBBP, CTCF, DAB2, DDX5, DEDD, DNMT3L, DVL1, E2F4, EID2, EIF4B, EP300, ERBB2IP, FHL1, FHL2, FHL3, FOS, FOXH1, FOXM1, GSK3B, HDAC1, HDAC4, HDAC5, HIF1A, HIPK2, HNF4A, HYAL2, IRF7, ITCH, JUN, JUNB, JUND, KAT2B, KAT6A, KPNB1, LCK, LEF1, LEMD3, MAX, MDM4, MECOM, MYC, MYOCD, NEDD4, NEDD4L, NEDD9, NFIA, NOTCH1, NR3C1, NUP153, NUP214, PARD3, PIAS2, PIAS3, PIAS4, PIK3CA, PIN1, RBL1, RUNX2, S100A4, SH2D2A, SIN3A, SKI, SKIL, SMAD3, SMAD4, SMURF2, SNW1, SP1, STUB1, TFE3, TGFB1I1, TGFBR1, TGIF1, TP53, TRIM24, TRIM33, TRIM62, TSC2, UCHL5, USP15, VDR, WWOX, XPO6, YY1, ZFYVE9, ZMIZ1\\n• Interactions from human data (Two-hybrid): AATF, AES, ANK3, APMAP, APOB, AR, ATF2, BLZF1, C10ORF54, C14ORF105, CCDC33, CDC25A, CFDP1, CFH, CFLAR, CHRD, CORO1A, CPSF7, CPTP, CREBBP, CRX, CSH2, CXXC5, CYP11A1, DEDD, DNAJB4, DNAJB5, EBI3, EP300, EPAS1, FAM90A1, FBLN1, FLI1, FLNA, FOS, FOXH1, GGA1, GIT2, GMEB1, HDAC1, HEY1, HEYL, HIF1A, HIVEP1, HNRNPK, HOXC11, HP, ISL1, JUN, JUNB, KANSL1, KDM2A, KMT2B, LBP, MCM3AP, MEOX2, MTF2, MYC, MYD88, NCOA6, NEDD4, NEDD9, NR4A1, PAPPA, PARP4, PCDH1, PCK2, PHC2, PIAS4, PIN1, PLAG1, PLAGL1, PLG, PPP1R12C, PPP2R1A, PRDM4, PROX1, PSMB1, PSMD11, RANBP9, RBPMS, RBX1, RCVRN, RELA, RIOK2, RNF31, RPA1, RPLP0, SAP130, SBK3, SERTAD1, SETD2, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMURF1, SMURF2, SNRNP70, SNW1, SP1, SQSTM1, SS18L1, ST6GALNAC2, SVEP1, TANK, TDP2, TEKT4, TF, TGM2, TLR4, TMED1, TSC22D4, UBQLN4, USP7, VDR, WWP1, WWP2, XRCC6, ZBTB16, ZBTB3, ZC3H12A, ZCCHC14, ZEB2, ZFYVE9, ZMYND11, ZNF329, ZNF774, ZNF83\\n• Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF6, ARHGEF7, CLASRP, FBXO3, GSC, MAP2K3, PPP2R2D, RAB38, RASD2, RGS3, RRAS2, SMAD2, SMAD3, SQSTM1, TRIM35, WEE1, WWP2\\n• Interactions from additional (non-human) data: (Affinity Capture-MS): ATG16L1, E6, NSP6, OTUB1, SMAD3\\n• Interactions from additional (non-human) data: (Affinity Capture-Western): AXIN1, COL1A1, COL3A1, COL5A1, DDX5, DOK1, E6, E7, EP300, GATA4, GNB2L1, HCVGP1, HDAC4, KLF4, MED15, MELK, N, RNF111, SKI, SMAD3, SMAD3A, SMAD4, TGFB1I1, TOB1, TOB1A, TOB1B, VDR, ZEB1\\n• Interactions from additional (non-human) data: (Co-localization): E7, N\\n• Interactions from additional (non-human) data: (PCA): E6\\n• Interactions from additional (non-human) data: (Phenotypic Enhancement): SMAD3A\\n• Interactions from additional (non-human) data: (Phenotypic Suppression): SMAD3A\\n• Interactions from additional (non-human) data: (Proximity Label-MS): M\\n• Interactions from additional (non-human) data: (Reconstituted Complex): E6, E7, GATA4, N, SIN3A, SMAD3, SOX9, YAP1, ZFP128\\n• Interactions from additional (non-human) data: (Synthetic Growth Defect): MMP9\\n• Interactions from additional (non-human) data: (Two-hybrid): DVL1, E6, ERBB2IP, FOXH1, GATA4, HCVGP1, JUN, MAGI2, PARD3, SMAD3, ZEB2\\n• *Protein: Gene: SMAD3 UniProt ID: P84022 Protein ID: P84022_F1 pLDDT: min=29.87 max=98.82 avg=83.68637647058827 FPocket: min=0.0 max=0.136 avg=0.009874901960784294 SASA: min=0.0 max=259.032 avg=66.18526352941177 total_area=28128.737 Polarity Index: min=-1.0 max=1.0 avg=-0.2885017125237185 Disorder consensus: min=0.0174 max=0.8685 pct_disordered=22.58823529411765 num_regions=4 longest_region=67 avg_short=0.2719049411764705 avg_long=0.30548564705882375 n_disprot_regions=2 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0152 max=0.894 pct_high=13.882352941176471 num_segments=1 longest_segment=59 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: P84022 CysDB Cysteines Entries: detected=5, hyperreactive=0, ligandable=0, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=0\\n• *Protein: Interpretation Notes AlphaFold pLDDT (Predicted Local Distance Difference Test) Per-residue confidence score from AlphaFold (0-100): - >90 : very high reliability - 70-90 : backbone usually correct - <70 : lower confidence, often flexible FPocket Druggability Score (0-1) Estimate of drug-likeness of a pocket. Solvent Accessible Surface Area (SASA) Computed per residue using FreeSASA (A^2). Polarity Index (PI) Derived from polar vs. apolar surface area decomposition. Structural Disorder Consensus Score Integrates IUPred3 and DisProt. MoRF Propensity (ANCHOR2) Regions disordered in isolation but fold on binding. CysDB cysteine chemoproteomics and functional context. Flags are derived from curated chemoproteomics datasets and structural annotations: - detected: cysteine was detected in at least one chemoproteomics experiment. - ligandable: competition with a covalent probe indicates ligandable behavior. - hyperreactive: elevated intrinsic reactivity relative to baseline. - is_act_site: annotated as an active-site (catalytic) cysteine. - near_act_site: spatially close to an active-site residue within a distance threshold. - is_bind_site: lies in a ligand-binding site based on structural or UniProt annotations. - near_bind_site: spatially close to a ligand-binding site residue. Neighbor lists indicate nearby active-site or binding-site residues (for example: G324, G326, S329). For details on CysDB, see: Boatner, L. M. et al. Cell Chem. Biol. 2023, 30(6), 683-698.e3. DOI: 10.1016/j.chembiol.2023.04.004.\\n• *ChEMBL: Gene: SMAD3 UniProt ID: P84022 Bioactivity evidence (normalized to nM): - CHEMBL601757 IC50=38.00 nM (n=1), pChEMBL=7.42 - CHEMBL1334062 IC50=39.00 nM (n=1), pChEMBL=7.41 - CHEMBL6246 (ELLAGIC ACID) IC50=142.00 nM (n=1), pChEMBL=6.85 - CHEMBL1484547 IC50=771.00 nM (n=1), pChEMBL=6.11 - CHEMBL375328 IC50=1250.00 nM (n=1) - CHEMBL1368373 IC50=1770.00 nM (n=1), pChEMBL=5.75 - CHEMBL1498509 IC50=2000.00 nM (n=1), pChEMBL=5.70 - CHEMBL1460342 IC50=2300.00 nM (n=1), pChEMBL=5.64 - CHEMBL1603774 IC50=2500.00 nM (n=1) - CHEMBL1485589 IC50=2500.00 nM (n=2), pChEMBL=4.45 - CHEMBL1490147 IC50=2500.00 nM (n=1) - CHEMBL1502394 IC50=2729.00 nM (n=1), pChEMBL=5.56 - CHEMBL1550490 IC50=2815.00 nM (n=1), pChEMBL=5.55 - CHEMBL210574 (PYROCATECHOL VIOLET) IC50=3276.96 nM (n=1), pChEMBL=5.49 - CHEMBL1609907 IC50=3967.99 nM (n=1), pChEMBL=5.40 - CHEMBL1498705 IC50=4098.00 nM (n=1), pChEMBL=5.39 - CHEMBL1057 IC50=4890.00 nM (n=1), pChEMBL=5.31 - CHEMBL1436701 IC50=6426.92 nM (n=1), pChEMBL=5.19 - CHEMBL1319324 IC50=6510.69 nM (n=1), pChEMBL=5.19 - CHEMBL1360077 IC50=6959.48 nM (n=1), pChEMBL=5.16 - CHEMBL1563062 IC50=8699.00 nM (n=1), pChEMBL=5.06 - CHEMBL1461262 IC50=8777.00 nM (n=1), pChEMBL=5.06 - CHEMBL1449293 IC50=9462.00 nM (n=1), pChEMBL=5.02 - CHEMBL1316752 IC50=9658.01 nM (n=1), pChEMBL=5.01 - CHEMBL417727 IC50=9894.00 nM (n=1), pChEMBL=5.00\\n• *ChEMBL: Interpretation Notes\\n- Bioactivity values are normalized to nM and aggregated per compound.\\n- Only positive numeric IC50 / Ki / EC50 values with molar units were considered.\\n- Reported values are the lowest (strongest) potency observed per assay type.\\n- pChEMBL is -log10(molar potency): higher values = stronger activity.\\n- Molecule type is taken directly from ChEMBL (Small molecule, Protein, Antibody, etc.).\\n- Canonical SMILES are provided for RDKit.js 2D rendering.\\n- InChIKeys are provided for PubChem enrichment.\\n- Includes drug indication, mechanism, approval, withdrawal flag, and black-box info (if available).\\n- Black-box text and FDA label links are retrieved from the openFDA API.\\n- Schema version = 35.0 (local snapshot).\\n- These summaries are heuristic and not a substitute for experimental validation.\\n• *MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD3: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_G2M_CHECKPOINT, HALLMARK_UV_RESPONSE_DN, HALLMARK_TGF_BETA_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD3: chr15q22. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD3: KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, BIOCARTA_NTHI_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, WP_FIBROTIC_RESPONSE_OF_HUMAN_TRABECULAR_MESHWORK_CELLS_TO_TRANSFORMING_GROWTH_FACTORBETA_3_TGFB3_AND_AUTOTAXIN_ENPP2_OR_ATX_IN_AQUEOUS_HUMOR, MITSIADES_RESPONSE_TO_APLIDIN_UP, TSAI_RESPONSE_TO_RADIATION_THERAPY, PUJANA_BREAST_CANCER_LIT_INT_NETWORK, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, PID_TELOMERASE_PATHWAY, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_HEPATITIS_C_AND_HEPATOCELLULAR_CARCINOMA, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, BROWNE_HCMV_INFECTION_4HR_DN, BROWNE_HCMV_INFECTION_14HR_DN, KIM_WT1_TARGETS_UP, RUTELLA_RESPONSE_TO_HGF_DN, DESERT_PERIVENOUS_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, LEI_MYB_TARGETS, FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, MARTINEZ_RESPONSE_TO_TRABECTEDIN, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, REACTOME_INFECTIOUS_DISEASE, REACTOME_SIGNALING_BY_INTERLEUKINS, SANA_TNF_SIGNALING_UP, REACTOME_SARS_COV_1_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS, JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_UP, WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES, REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, NAKAMURA_ADIPOGENESIS_LATE_DN, REACTOME_SARS_COV_1_HOST_INTERACTIONS, REACTOME_SIGNALING_BY_NODAL, REACTOME_RUNX3_REGULATES_CDKN1A_TRANSCRIPTION, PID_SMAD2_3NUCLEAR_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION, REACTOME_FORMATION_OF_AXIAL_MESODERM, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN, WP_CELL_CYCLE, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, CAIRO_HEPATOBLASTOMA_CLASSES_DN, PID_MYC_ACTIV_PATHWAY, SHEPARD_CRASH_AND_BURN_MUTANT_DN, ZHENG_BOUND_BY_FOXP3, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, RYAN_MANTLE_CELL_LYMPHOMA_NOTCH_DIRECT_UP, REACTOME_INTERLEUKIN_37_SIGNALING, FLORIO_NEOCORTEX_BASAL_RADIAL_GLIA_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, DACOSTA_UV_RESPONSE_VIA_ERCC3_DN, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, GENTILE_UV_RESPONSE_CLUSTER_D6, GENTILE_UV_HIGH_DOSE_DN, REACTOME_DEUBIQUITINATION, REACTOME_SARS_COV_INFECTIONS, BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, PULVER_FOREY_CELLCYCLE_PEAKING_M, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, BENPORATH_NANOG_TARGETS, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, DOANE_RESPONSE_TO_ANDROGEN_DN, REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING, MARTENS_BOUND_BY_PML_RARA_FUSION, FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS, MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN, RIZ_ERYTHROID_DIFFERENTIATION_6HR, REACTOME_SARS_COV_1_INFECTION, WP_HIPPO_SIGNALING_REGULATION, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP, JINESH_BLEBBISHIELD_TO_IMMUNE_CELL_FUSION_PBSHMS_UP, PID_MYC_REPRESS_PATHWAY, WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE, ONKEN_UVEAL_MELANOMA_UP, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_S2, PHONG_TNF_RESPONSE_VIA_P38_PARTIAL, JOHNSTONE_PARVB_TARGETS_2_UP, OKUMURA_INFLAMMATORY_RESPONSE_LPS, BIOCARTA_TOB1_PATHWAY, GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_DN, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, DAZARD_RESPONSE_TO_UV_NHEK_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, FIGUEROA_AML_METHYLATION_CLUSTER_3_UP, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, BENPORATH_MYC_MAX_TARGETS, WP_INTEGRATED_CANCER_PATHWAY, KEGG_CHRONIC_MYELOID_LEUKEMIA, REACTOME_SIGNALING_BY_TGFBR3, BENPORATH_SOX2_TARGETS, KEGG_TGF_BETA_SIGNALING_PATHWAY, WP_ANDROGEN_RECEPTOR_SIGNALING, PULVER_FOREY_CELLCYCLE_ENRICHED_TFS_G2, JOHNSTONE_PARVB_TARGETS_3_UP, BIOCARTA_TGFB_PATHWAY, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, TSAI_RESPONSE_TO_IONIZING_RADIATION, LAMB_CCND1_TARGETS, REACTOME_VIRAL_INFECTION_PATHWAYS, WP_TGFB_SMAD_SIGNALING, DAZARD_UV_RESPONSE_CLUSTER_G6, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, REACTOME_SIGNALING_BY_NOTCH, FRASOR_RESPONSE_TO_ESTRADIOL_DN, ZIRN_TRETINOIN_RESPONSE_WT1_UP, KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3, BROWNE_HCMV_INFECTION_8HR_DN, ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF, REN_ALVEOLAR_RHABDOMYOSARCOMA_DN, REACTOME_RUNX3_REGULATES_BCL2L11_BIM_TRANSCRIPTION, PID_HIF1_TFPATHWAY, GRUETZMANN_PANCREATIC_CANCER_UP, CHICAS_RB1_TARGETS_CONFLUENT, YEMELYANOV_GR_TARGETS_DN, WP_OVARIAN_INFERTILITY, PHONG_TNF_RESPONSE_NOT_VIA_P38, WP_ADIPOGENESIS, DANG_BOUND_BY_MYC, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN, BIOCARTA_G1_PATHWAY, REACTOME_SIGNALING_BY_NOTCH4, SERVITJA_ISLET_HNF1A_TARGETS_UP, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, WP_ANGIOTENSIN_II_RECEPTOR_TYPE_1_PATHWAY, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, CHANDRAN_METASTASIS_DN, WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT, PEREZ_TP53_TARGETS, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, KIM_WT1_TARGETS_12HR_UP, WP_BURN_WOUND_HEALING, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_SENESCENCE_AND_AUTOPHAGY_IN_CANCER, PID_TGFBR_PATHWAY, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, BROWNE_HCMV_INFECTION_6HR_DN, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, REACTOME_TGFBR3_EXPRESSION, SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1, KEGG_COLORECTAL_CANCER, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN, REACTOME_SIGNALING_BY_ACTIVIN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD3: WGGAATGY_TEF1_Q6, MIR302D_5P, GTTAAAG_MIR302B, MIR8080, PXR_Q2, SRY_02, GGCAGAC_MIR346, HDAC4_TARGET_GENES, ZNF563_TARGET_GENES, ZNF766_TARGET_GENES, MEF2C_TARGET_GENES, ZFHX3_TARGET_GENES, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, MIR524_5P, MIR6129, ZFP3_TARGET_GENES, E12_Q6, ZSCAN30_TARGET_GENES, GREB1_TARGET_GENES, MIR3120_5P, MIR668_3P, MYOD_Q6_01, RYTTCCTG_ETS2_B, MIR6127, MIR145_5P, TAL1BETAE47_01, SKIL_TARGET_GENES, MIR6130, ZNF436_TARGET_GENES, AACTGGA_MIR145, NR0B1_TARGET_GENES, KMT2D_TARGET_GENES, SNAI1_TARGET_GENES, TAL1ALPHAE47_01, MED25_TARGET_GENES, MIR20A_3P, TFEB_TARGET_GENES, TBX1_TARGET_GENES, MIR6886_3P, AATGTGA_MIR23A_MIR23B, SUPT16H_TARGET_GENES, AGCTCCT_MIR28, NGFIC_01, MIR3194_3P, ZNF512B_TARGET_GENES, TAL1BETAITF2_01, GATA1_05, ZNF282_TARGET_GENES, ZNF740_TARGET_GENES, ZSCAN2_TARGET_GENES, MIR6762_5P, MIR561_3P, MIR617, ZNF92_TARGET_GENES, HMX1_01, LFA1_Q6, MIR6845_5P, DLX2_TARGET_GENES, SALL4_TARGET_GENES, MIR520D_5P, MIR4778_3P, MIR302B_5P, MIR6765_3P, CTTTGTA_MIR524, MIR4510, MIR520G_3P_MIR520H, MIR6133, MIR5195_3P, CTAWWWATA_RSRFC4_Q2, SFMBT1_TARGET_GENES, ARID5B_TARGET_GENES, EWSR1_TARGET_GENES, COUP_DR1_Q6, MIR3658, GCTNWTTGK_UNKNOWN, ZNF596_TARGET_GENES, ZSCAN5DP_TARGET_GENES, ATGTCAC_MIR489, NAB2_TARGET_GENES, ZNF746_TARGET_GENES, PBXIP1_TARGET_GENES, MIR3154, FXR_IR1_Q6, MIR5787, ADNP_TARGET_GENES, MIR4505. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD3: MODULE_378, MODULE_37, MODULE_57, MODULE_129, MODULE_179, MODULE_3, MODULE_69, MODULE_70, MODULE_117, MODULE_138, MODULE_255, MODULE_459, MODULE_532, MODULE_18, MODULE_136, MODULE_33, MODULE_317. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD3: RPS14_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD3: GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE39820_CTRL_VS_IL1B_IL6_CD4_TCELL_DN, GSE29949_MICROGLIA_VS_DC_BRAIN_DN, GSE22886_NAIVE_BCELL_VS_DC_UP, GSE4535_BM_DERIVED_DC_VS_FOLLICULAR_DC_UP, GSE9946_LISTERIA_INF_MATURE_VS_PROSTAGLANDINE2_TREATED_MATURE_DC_UP, GSE20366_TREG_VS_TCONV_UP, GSE12963_UNINF_VS_ENV_AND_NEF_DEFICIENT_HIV1_INF_CD4_TCELL_UP, GSE40443_INDUCED_VS_TOTAL_TREG_UP, GSE21360_NAIVE_VS_PRIMARY_MEMORY_CD8_TCELL_UP, GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE1460_DP_VS_CD4_THYMOCYTE_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_48H_CD8_T_CELL_DN, GSE21360_SECONDARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN, GSE12845_PRE_GC_VS_DARKZONE_GC_TONSIL_BCELL_UP, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP, GSE13306_RA_VS_UNTREATED_MEM_CD4_TCELL_UP, GSE26030_TH1_VS_TH17_DAY5_POST_POLARIZATION_DN, GSE3982_MAC_VS_TH1_DN, GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP, GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN, GSE20727_CTRL_VS_H2O2_TREATED_DC_DN, GSE17721_LPS_VS_PAM3CSK4_4H_BMDC_UP, GSE41867_NAIVE_VS_DAY6_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN, GSE369_IFNG_KO_VS_WT_LIVER_UP, GSE9946_MATURE_STIMULATORY_VS_LISTERIA_INF_MATURE_DC_UP, NAKAYA_B_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE36078_WT_VS_IL1R_KO_LUNG_DC_AFTER_AD5_INF_UP, GSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP, GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_UP, GSE7852_LN_VS_FAT_TREG_DN, GSE17186_NAIVE_VS_CD21LOW_TRANSITIONAL_BCELL_UP, GSE43955_1H_VS_20H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP, GSE26495_NAIVE_VS_PD1LOW_CD8_TCELL_DN, GSE30962_ACUTE_VS_CHRONIC_LCMV_PRIMARY_INF_CD8_TCELL_UP, GSE2585_CTEC_VS_THYMIC_DC_DN, GSE27291_0H_VS_7D_STIM_GAMMADELTA_TCELL_DN, GSE14350_TREG_VS_TEFF_UP, GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IFNG_TNF_TREATED_MACROPHAGE_DN, GSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_6H_DN, GSE14415_INDUCED_TREG_VS_TCONV_DN, GSE16385_MONOCYTE_VS_12H_ROSIGLITAZONE_IL4_TREATED_MACROPHAGE_DN, GSE19941_UNSTIM_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP, GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP, GSE36826_NORMAL_VS_STAPH_AUREUS_INF_SKIN_UP, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE26495_NAIVE_VS_PD1HIGH_CD8_TCELL_DN, GSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP, GSE29949_MICROGLIA_BRAIN_VS_MONOCYTE_BONE_MARROW_DN, GSE7548_NAIVE_VS_DAY7_PCC_IMMUNIZATION_CD4_TCELL_DN, GSE3039_ALPHAALPHA_CD8_TCELL_VS_B1_BCELL_DN, GSE17721_PAM3CSK4_VS_GADIQUIMOD_4H_BMDC_DN, GSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_UP, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_4H_DN, NAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_DN, GSE17186_MEMORY_VS_NAIVE_BCELL_UP, GSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP, GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN, GSE9988_ANTI_TREM1_AND_LPS_VS_CTRL_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_BM_PLASMA_CELL_UP, GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP, GSE7219_UNSTIM_VS_LPS_AND_ANTI_CD40_STIM_DC_UP, GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN, GSE7768_OVA_ALONE_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_UP, GSE18791_UNSTIM_VS_NEWCATSLE_VIRUS_DC_6H_DN, GSE17186_NAIVE_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN, GSE7852_THYMUS_VS_FAT_TREG_DN, GSE36392_TYPE_2_MYELOID_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP, GSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_UP, GSE23114_WT_VS_SLE2C1_MOUSE_PERITONEAL_CAVITY_B1A_BCELL_UP, GSE43863_TH1_VS_TFH_MEMORY_CD4_TCELL_UP, GSE360_CTRL_VS_L_MAJOR_MAC_UP, GSE12003_4D_VS_8D_CULTURE_MIR223_KO_BM_PROGENITOR_DN, GSE11057_NAIVE_VS_MEMORY_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_CD8_TCELL_UP, GSE41087_WT_VS_FOXP3_MUT_ANTI_CD3_CD28_STIM_CD4_TCELL_UP, GSE6259_FLT3L_INDUCED_VS_WT_SPLENIC_DC_33D1_POS_UP, GSE3920_IFNA_VS_IFNG_TREATED_FIBROBLAST_UP, GSE1460_DP_THYMOCYTE_VS_THYMIC_STROMAL_CELL_DN, GSE40273_EOS_KO_VS_WT_TREG_UP, GSE25123_WT_VS_PPARG_KO_MACROPHAGE_UP, GSE43955_1H_VS_60H_ACT_CD4_TCELL_UP, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, GSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN, GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_UP, GSE39820_TGFBETA1_VS_TGFBETA3_IN_IL6_TREATED_CD4_TCELL_UP, GSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN, GSE3982_EFF_MEMORY_CD4_TCELL_VS_NKCELL_UP, GSE15324_NAIVE_VS_ACTIVATED_ELF4_KO_CD8_TCELL_UP, GSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN, GSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN, GSE12505_WT_VS_E2_2_HET_PDC_UP, GSE22886_NAIVE_VS_IGM_MEMORY_BCELL_UP, GSE40274_FOXP3_VS_FOXP3_AND_IRF4_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE7768_OVA_WITH_LPS_VS_OVA_WITH_MPL_IMMUNIZED_MOUSE_WHOLE_SPLEEN_6H_UP, GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN, GSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_1H_UP, GSE25123_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_MACROPHAGE_UP, GSE3039_CD4_TCELL_VS_ALPHABETA_CD8_TCELL_UP, GSE27786_CD4_TCELL_VS_NKTCELL_DN, GSE17721_CPG_VS_GARDIQUIMOD_24H_BMDC_DN, GSE26030_UNSTIM_VS_RESTIM_TH1_DAY15_POST_POLARIZATION_UP, NAKAYA_MYELOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN, GSE2585_CTEC_VS_MTEC_THYMUS_UP, GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP, GSE43863_TFH_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_TH1_CD4_TCELL_UP, GSE7764_NKCELL_VS_SPLENOCYTE_UP, GSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_DN, GSE7460_CTRL_VS_TGFB_TREATED_ACT_FOXP3_MUT_TCONV_UP, GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN, GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN, GSE43863_DAY6_EFF_VS_DAY150_MEM_LY6C_INT_CXCR5POS_CD4_TCELL_UP, GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_DN, GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN, GSE22886_NAIVE_BCELL_VS_NEUTROPHIL_UP, GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD3: FAN_OVARY_CL11_MURAL_GRANULOSA_CELL, MURARO_PANCREAS_DUCTAL_CELL, GAUTAM_EYE_CORNEA_ELF3_HIGH_EPITHELIAL_CELLS, FAN_OVARY_CL8_MATURE_CUMULUS_GRANULOSA_CELL_2, HE_LIM_SUN_FETAL_LUNG_C6_MUC16_POS_CILIATED_CELL, HU_FETAL_RETINA_FIBROBLAST, HE_LIM_SUN_FETAL_LUNG_C7_PROLIFERATING_SCHWANN_CELL, MURARO_PANCREAS_ACINAR_CELL, HE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL, HU_FETAL_RETINA_RPE.\\n• *UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) Associated diseases: Colorectal cancer, Loeys-Dietz syndrome 3.\\n• *OpenTargets: Direct disease associations for SMAD3: Large for gestational age, Alopecia, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Right ventricular hypertrophy, Myocardial fibrosis, Hallux valgus, Increased total eosinophil count, Acute kidney injury, Renal artery stenosis, Hypoglycemia, Glucose intolerance, Abnormal thrombosis, Rectal prolapse, Esophageal stricture, Pulmonary hypoplasia, Asthma, Cerebral cortical atrophy, Ischemic stroke, Aortic root aneurysm, Aortic dissection, Spontaneous pneumothorax, Vascular dilatation, Cerebral ischemia, Immunodeficiency, Systemic lupus erythematosus, Oral leukoplakia, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Back pain, Muscular dystrophy, Hernia of the abdominal wall, Cachexia, Ascending aortic dissection, Venous thrombosis, Ascending tubular aorta aneurysm, Ureteral obstruction, Airway obstruction, Pituitary prolactin cell adenoma, Premature ovarian insufficiency, Intervertebral disk degeneration, Lipodystrophy, Hamartoma, Chordoma, Stress urinary incontinence, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Urethral stricture, Allergy, Renal atrophy, Pulmonary bulla, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Hernia, Sepsis, Skin ulcer, Left ventricular dilatation, colorectal adenoma, airway hyperresponsiveness, skin aging, adolescent idiopathic scoliosis, triple-negative breast cancer, bile duct carcinoma, glioma, gamma chain deficiency, seborrheic keratosis, rectal adenocarcinoma, intracerebral hemorrhage, smoking initiation, Staphylococcus aureus infection, rheumatic disease, lupus nephritis, pulse pressure measurement, neurodegenerative disease, retinal detachment, Autoimmune Hepatitis, non-high density lipoprotein cholesterol measurement, brain disease, aortic disease, neonatal abstinence syndrome, allergic rhinitis, esophageal squamous cell carcinoma, non-Hodgkins lymphoma, breast ductal adenocarcinoma, systolic blood pressure, diastolic blood pressure, pulmonary artery enlargement, laryngeal squamous cell carcinoma, cystadenocarcinoma, ovarian mucinous adenocarcinoma, smoking status measurement, bladder transitional cell carcinoma, brain glioblastoma, cerebral amyloid angiopathy, autoimmune thyroid disease, stricture, head and neck malignant neoplasia, urgency urinary incontinence, fibrosis, diastolic blood pressure change measurement, drug use measurement, allergic conjunctivitis, aortic valve insufficiency, Balkan nephropathy, bronchiolitis obliterans, congenital rubella, coronavirus infectious disease, echinococcosis, endodermal sinus tumor, Gerstmann syndrome, Guillain-Barre syndrome, influenza, intestinal cancer, legionellosis, lymphatic system disease, male reproductive organ cancer, aneurysm-osteoarthritis syndrome, autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome, hyperuricemic nephropathy, familial juvenile type 3, graft versus host disease, autoimmune lymphoproliferative syndrome type 4, combined immunodeficiency due to LRBA deficiency, adenine phosphoribosyltransferase deficiency, karyomegalic interstitial nephritis, dyskeratosis congenita, autosomal recessive 5, TCR-alpha-beta-positive T-cell deficiency, severe combined immunodeficiency due to IKK2 deficiency, immunodeficiency 18, immunodeficiency 23, severe combined immunodeficiency due to CTPS1 deficiency, severe neurodegenerative syndrome with lipodystrophy, periodic fever-infantile enterocolitis-autoinflammatory syndrome, immunodeficiency 37, chronic atrial and intestinal dysrhythmia, DOCK2 deficiency, DDX41-related hematologic malignancy predisposition syndrome, fibrochondrogenesis 2, C3 glomerulonephritis, agammaglobulinemia 7, autosomal recessive, autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency, infantile-onset periodic fever-panniculitis-dermatosis syndrome, lung disease, immunodeficiency, and chromosome breakage syndrome;, neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade, chronic diarrhea due to glucoamylase deficiency, Bardet-Biedl syndrome, familial pancreatic carcinoma, nasopharyngeal carcinoma, craniosynostosis, keratoconus, common variable immunodeficiency, hyperplastic polyposis syndrome, dentin dysplasia, T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, qualitative or quantitative defects of dysferlin, holoprosencephaly, attenuated familial adenomatous polyposis, isolated agammaglobulinemia, pachyonychia congenita, familial hyperaldosteronism, hypohidrotic ectodermal dysplasia, primary ciliary dyskinesia, APC-related attenuated familial adenomatous polyposis, meningioma, multiple epiphyseal dysplasia, hemangioblastoma, Moyamoya disease, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, IgG4-related disease, juvenile polyposis syndrome, pituitary tumor, ameloblastoma, exstrophy-epispadias complex, autoimmune lymphoproliferative syndrome, syringomyelia, selective IgM deficiency, persistent truncus arteriosus, colorectal adenocarcinoma, congestive heart failure, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, embryonal rhabdomyosarcoma, emphysema, epilepsy, fetal growth restriction, ganglioneuroma, gastric adenocarcinoma, esophageal adenocarcinoma, gastric intestinal type adenocarcinoma, glioblastoma multiforme, hypertension, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, tuberculosis, glioblastoma, chronic granulomatous disease, liver mesenchymal hamartoma, activated PI3K-delta syndrome, carcinoma of liver and intrahepatic biliary tract, cutaneous polyarteritis nodosa, hereditary nonpolyposis colon cancer, Polymerase proofreading-related adenomatous polyposis, Zika virus infectious disease, regressive spondylometaphyseal dysplasia, Jeune syndrome, Li-Fraumeni syndrome, posterior cortical atrophy, 22q11.2 deletion syndrome, Loeys-Dietz syndrome, congenital membranous nephropathy due to maternal anti-neutral endopeptidase alloimmunization, intrahepatic cholestasis, bronchopulmonary dysplasia, Hirschsprung disease, mucinous adenocarcinoma of the appendix, Lhermitte-Duclos disease, sarcoidosis, peeling skin syndrome, Fanconi anemia, dysspondyloenchondromatosis, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, acute liver failure, discoid lupus erythematosus, familial thoracic aortic aneurysm and aortic dissection, renal hypoplasia, renal dysplasia, spondyloepiphyseal dysplasia tarda, ulnar hemimelia, radial hemimelia, growth hormone-producing pituitary gland neoplasm, encephalitis, Ehlers-Danlos syndrome, muscular dystrophy, autosomal dominant cerebellar ataxia, precursor B-cell acute lymphoblastic leukemia, chronic graft versus host disease, superficial spreading melanoma, renal pelvis/ureter urothelial carcinoma, tubulointerstitial kidney disease, autosomal dominant, 2, lung neoplasm, intestinal neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, neoplasm of esophagus, tumor of parathyroid gland, polyp of colon, low grade glioma, coronary atherosclerosis, gram-negative bacterial infections, sexually transmitted disease, radiculitis, viral myocarditis, lip and oral cavity carcinoma, immunodeficiency 14b, autosomal recessive, corneal infection, pseudoxanthoma elasticum (inherited or acquired), respiratory tract infectious disorder, chondrogenic neoplasm, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, synucleinopathy, pulmonary sarcoidosis, gonorrhea, chronic lymphocytic leukemia, neoplasm of mature B-cells, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, metastatic prostate cancer, T-cell acute lymphoblastic leukemia, unspecified peripheral T-cell lymphoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, oral squamous cell carcinoma, acute lymphoblastic leukemia, acute myeloid leukemia, adenocarcinoma, adenoma, adenosquamous lung carcinoma, adrenal gland pheochromocytoma, alveolar rhabdomyosarcoma, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, benign prostatic hyperplasia, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, Burkitts lymphoma, carcinoma, cardiomyopathy, cardiovascular disease, chondrosarcoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, chronic pancreatitis, clear cell renal carcinoma, endometrial carcinoma, renal fibrosis, Adenomyosis, immunoproliferative small intestinal disease, Posterior Leukoencephalopathy Syndrome, amyloidosis, neuroendocrine neoplasm, Spinal cord injury, B-cell non-Hodgkins lymphoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, intrahepatic cholangiocarcinoma, pharyngeal squamous cell carcinoma, connective tissue disease, pneumonitis, Carcinoma, Lewis Lung, soft tissue sarcoma, adult onset asthma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, renal hypertension, glomerular disease, nephritis, positive regulation of ovulation, Neurogenic bladder, Inguinal hernia, Abnormality of the urinary system, Renal insufficiency, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Nephrocalcinosis, Uterine leiomyoma, Cleft palate, Retrognathia, Strabismus, Cataract, Proptosis, Myopia, Pectus excavatum, Infertility, Hematuria, Diabetes mellitus, Hyperinsulinemia, Insulin resistance, Abnormality of the skeletal system, Osteopenia, Osteoporosis, Jaundice, Eczematoid dermatitis, Global developmental delay, Stroke, Encephalopathy, Parkinsonism, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Cholestasis, Hepatic steatosis, Obesity, ornithine carbamoyltransferase deficiency, pseudomyxoma peritonei, silicosis, spinal stenosis, BMI-adjusted waist-hip ratio, BMI-adjusted waist circumference, body fat percentage, balding measurement, liver dysplastic nodule, wellbeing measurement, insomnia measurement, eosinophil percentage of leukocytes, eosinophil percentage of granulocytes, BMI-adjusted hip circumference, calf circumference measurement, chronic hepatitis, dysplasia, interstitial cystitis, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, oral lichen planus, rhinitis, small cell carcinoma, status epilepticus, steatosis, urothelial carcinoma, Hepatobiliary Neoplasm, acute myocardial infarction, peritonitis, pemphigus foliaceus, paraneoplastic pemphigus, cystic kidney disease, ovarian dysfunction, Arteritis, Polyarteritis Nodosa, arteriosclerosis, idiopathic dilated cardiomyopathy, hyperuricemia, female reproductive endometrioid cancer, skin carcinoma, heel bone mineral density, marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections, central nervous system disease, sum of eosinophil and basophil counts, lower respiratory tract disease, pulmonary fibrosis, infarction, corneal disease, vertebral joint disease, aortic valve disease, cervical disc degenerative disorder, hemorrhoid, mitral valve disease, feeling nervous measurement, stomach disease, myocarditis, aneurysm, laryngeal disease, musculoskeletal system disease, Gallbladder Adenocarcinoma, Gallbladder Adenoma, Gastric Neuroendocrine Tumor G1, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Mast Cell Sarcoma, Nasal Cavity Polyp, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Ovarian Granulosa Cell Tumor, Peritoneal Multicystic Mesothelioma, Pituitary Gland Adenoma, Placental Choriocarcinoma, Pleural Epithelioid Mesothelioma, Poorly Differentiated Thyroid Gland Carcinoma, Rectal Tubular Adenoma, Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions, Signet Ring Cell Gastric Adenocarcinoma, small intestinal adenocarcinoma, Spinal Chordoma, Testicular Embryonal Carcinoma, Thyroid Gland Oncocytic Follicular Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vaginal Melanoma, hamartoma, acute respiratory distress syndrome, rectum cancer, acanthosis nigricans, cholesteatoma, Primary Pulmonary Diffuse Large B-Cell Lymphoma, developmental dysplasia of the hip, sarcopenia, mucous membrane pemphigoid, osteoarthritis, hip, osteoarthritis, spine, adrenal cortex carcinoma, adrenal gland hyperfunction, alcoholic cardiomyopathy, aortitis, atrial heart septal defect, causalgia, coronary aneurysm, diastolic heart failure, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, joint disease, lipoid nephrosis, mouth disease, multiple system atrophy, myeloid sarcoma, ocular hypertension, parathyroid adenoma, proliferative vitreoretinopathy, pulmonary edema, pulpitis, Raynaud disease, renovascular hypertension, rheumatic heart disease, Schnitzler syndrome, thromboangiitis obliterans, ulcerative proctosigmoiditis, uremia, non-alcoholic steatohepatitis, rotator cuff tear, Anemia, Hemolytic, Autoimmune, Cardiac Tamponade, End Stage Liver Disease, Endometritis, Escherichia coli Infections, Genital neoplasm, female, Heavy Chain Disease, Hepatopulmonary Syndrome, Lentivirus Infections, Myocardial Ischemia, Periapical Periodontitis, Peritoneal Fibrosis, Tularemia, diabetic cardiomyopathy, endothelial dysfunction, gliosarcoma, Mantle cell lymphoma, Merkel cell skin cancer, metastatic colorectal cancer, enterocolitis, primary biliary cirrhosis, abortion, psoriasis vulgaris, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, primary hyperoxaluria type 2, hyperimmunoglobulinemia D with periodic fever, autosomal recessive polycystic kidney disease, Senior-Loken syndrome 1, reticular dysgenesis, schneckenbecken dysplasia, combined immunodeficiency due to ZAP70 deficiency, familial isolated congenital asplenia, brachyolmia type 1, Hobaek type, brachyolmia type 1, toledo type, spondyloperipheral dysplasia, thoracomelic dysplasia, congenital bilateral aplasia of vas deferens from CFTR mutation, Wilson disease, X-linked spondyloepimetaphyseal dysplasia, hypoxanthine guanine phosphoribosyltransferase partial deficiency, Bruton-type agammaglobulinemia, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, combined immunodeficiency due to moesin deficiency, Wiskott-Aldrich syndrome, Aarskog-Scott syndrome, X-linked, hyper-IgM syndrome type 1, Melnick-Needles syndrome, Bartsocas-Papas syndrome 1, pulmonary venoocclusive disease, spondyloepimetaphyseal dysplasia, Irapa type, SHOX-related short stature, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, spondyloepiphyseal dysplasia tarda, X-linked, T-B+ severe combined immunodeficiency due to JAK3 deficiency, Timothy syndrome, supranuclear palsy, progressive, 1, skeletal dysplasia-epilepsy-short stature syndrome, hereditary mixed polyposis syndrome, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive, Ehlers-Danlos syndrome, musculocontractural type, spondyloepimetaphyseal dysplasia, Missouri type, axial spondylometaphyseal dysplasia, severe combined immunodeficiency due to DCLRE1C deficiency, spondyloepimetaphyseal dysplasia, Shohat type, myotonic dystrophy type 2, radioulnar synostosis-microcephaly-scoliosis syndrome, spondyloepimetaphyseal dysplasia with multiple dislocations, Omenn syndrome, xanthinuria type II, autoimmune lymphoproliferative syndrome type 2A, nephronophthisis 3, pyogenic arthritis-pyoderma gangrenosum-acne syndrome, hyper-IgM syndrome type 2, immunodeficiency due to CD25 deficiency, lymphangioleiomyomatosis, gastrointestinal stromal tumor, hyper-IgM syndrome type 3, multiple epiphyseal dysplasia type 5, anauxetic dysplasia, autoimmune lymphoproliferative syndrome type 2B, Smith-McCort dysplasia 1, granular corneal dystrophy type II, acrocapitofemoral dysplasia, endometrial cancer, hyper-IgM syndrome type 5, hyper-IgM syndrome type 4, neutrophil immunodeficiency syndrome, familial adenomatous polyposis 2, spondyloepimetaphyseal dysplasia, matrilin-3 type, familial avascular necrosis of femoral head, immunodeficiency 104, spondylometaphyseal dysplasia, A4 type, epidermolysis bullosa simplex 7, with nephropathy and deafness, permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome, mesoaxial synostotic syndactyly with phalangeal reduction, hyperinsulinemic hypoglycemia, familial, 4, Mungan syndrome, familial cold autoinflammatory syndrome 2, aortic aneurysm, familial thoracic 6, hypouricemia, renal, 2, dopa-responsive dystonia due to sepiapterin reductase deficiency, combined immunodeficiency due to STIM1 deficiency, atypical hemolytic-uremic syndrome with MCP/CD46 anomaly, atypical hemolytic-uremic syndrome with I factor anomaly, atypical hemolytic-uremic syndrome with B factor anomaly, atypical hemolytic-uremic syndrome with C3 anomaly, atypical hemolytic-uremic syndrome with thrombomodulin anomaly, lymphoproliferative syndrome 1, purine nucleoside phosphorylase deficiency, spondylo-megaepiphyseal-metaphyseal dysplasia, brachydactylous dwarfism, Mseleni type, spondyloepimetaphyseal dysplasia, Handigodu type, hemolytic anemia due to glucophosphate isomerase deficiency, alpha 1-antitrypsin deficiency, occult macular dystrophy, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, polyp, preeclampsia, prostate adenocarcinoma, psoriasis, renal cell carcinoma, respiratory system disease, sarcoma, severe acute respiratory syndrome, Sjogren syndrome, skin disease, small cell lung carcinoma, rheumatoid arthritis, spindle cell tumor, spondyloarthropathy, squamous cell carcinoma, squamous cell lung carcinoma, systemic scleroderma, ulcerative colitis, uterine fibroid, melanoma, malignant peripheral nerve sheath tumor, viral disease, HIV infection, AIDS, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, temporal lobe epilepsy, myositis, leprosy, celiac disease, cervical carcinoma, cytomegalovirus infection, Down syndrome, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, lung carcinoma, ovarian carcinoma, post-traumatic stress disorder, pulmonary arterial hypertension, synovial sarcoma, autosomal dominant polycystic liver disease, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, small intestinal neuroendocrine tumor G1, breast benign neoplasm, central nervous system primitive neuroectodermal neoplasm, vertebral column disorder, cerebral cavernous malformation, interstitial emphysema, gastric cancer, essential hypertension, hypertensive heart disease, familial hyperlipidemia, impaired renal function disease, myopia, nephrocalcinosis, leiomyoma, prolapse of female genital organ, brain cancer, nontoxic goiter, pure red-cell aplasia, crescentic glomerulonephritis, tuberous sclerosis, depressive disorder, ventricular septal defect, pneumothorax, Richter syndrome, thyroid cancer, giant cell tumor, spondylosis, papilloma, kidney cancer, dermatitis, prostatic adenoma, lobular neoplasia, gingival overgrowth, papillary adenocarcinoma, digestive system cancer, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratocarcinoma, teratoma, bone inflammation disease, small cell osteogenic sarcoma, cerebral infarction, liver cancer, uterine cancer, anal canal adenocarcinoma, skin cancer, cerebellar neoplasm, cervical cancer, breast angiosarcoma, bile duct adenocarcinoma, thoracic cancer, colonic disorder, functioning pituitary gland adenoma, anal canal squamous cell carcinoma, pancreatic intraductal papillary-mucinous neoplasm, muscular atrophy, female breast carcinoma, retinal degeneration, MHC class II deficiency 4, immunodeficiency 122, inflammation, circulating fibrinogen levels, glomerular filtration rate, fat pad mass, hip circumference, bone tissue density, von Willebrand factor quality, waist circumference, age of onset of asthma, level of serum globulin type protein, red blood cell density, serum alanine aminotransferase amount, heart rate, age of onset of allergic disease, brain volume, serum albumin amount, serum creatinine amount, body height, cyst, X-linked hyper-IgM syndrome, Brachydactyly - elbow wrist dysplasia, Chronic mucocutaneous candidosis, Desbuquois syndrome, Chédiak-Higashi syndrome, Recurrent infection due to specific granule deficiency, Immunodeficiency syndrome with autoimmunity, Metaphyseal chondrodysplasia, Schmid type, Åland Islands eye disease, Ichthyosis - intellectual disability - dwarfism - renal impairment, Autosomal recessive early-onset inflammatory bowel disease, X-linked lymphoproliferative disease, Metaphyseal dysostosis - intellectual disability - conductive deafness, CHST3-related skeletal dysplasia, Cyclic neutropenia, Severe combined immunodeficiency due to adenosine deaminase deficiency, Aneurysm - osteoarthritis syndrome, Rare disease with thoracic aortic aneurysm and aortic dissection, Multiple osteochondromas, Recurrent infections-myelofibrosis-nephromegaly syndrome, Acromesomelic dysplasia, Maroteaux type, Hyperlipoproteinemia type 1, X-linked agammaglobulinemia, Familial hemophagocytic lymphohistiocytosis, Immunodeficiency by defective expression of HLA class 2, Pyogenic arthritis - pyoderma gangrenosum - acne, Familial adenomatous polyposis, Thymic aplasia, Other metabolic disease, Spondyloepimetaphyseal dysplasia - short limb - abnormal calcification, Hypohidrotic ectodermal dysplasia with immunodeficiency, Leukocyte adhesion deficiency type III, hematocrit, C-reactive protein measurement, glucose measurement, hemoglobin measurement, bone quantitative ultrasound measurement, triglyceride measurement, alkaline phosphatase measurement, creatine kinase measurement, cryptorchidism, total cholesterol measurement, gestational diabetes, low density lipoprotein cholesterol measurement, lymphocyte count, acute lung injury, high density lipoprotein cholesterol measurement, osteoarthritis, knee, cystatin C measurement, factor VII measurement, IGF-1 measurement, factor VIII measurement, white matter integrity, hip geometry, factor XI measurement, intraocular pressure measurement, sex hormone-binding globulin measurement, age at menarche, pelvic organ prolapse, FEV/FVC ratio, prion disease, aspartate aminotransferase measurement, protein measurement, neutrophil count, eosinophil count, lymph node metastatic carcinoma, appendicular lean mass, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, autoimmune disease, congenital heart disease, central corneal thickness, cholangiocarcinoma, reading, anxiety, primitive neuroectodermal tumor, aortic valve calcification, non-small cell lung adenocarcinoma, axial length measurement, contact dermatitis, vein disorder, in situ carcinoma, inborn disorder of amino acid metabolism, allergic asthma, fatty liver disease, alopecia, hypoplastic left heart syndrome, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, upper respiratory tract disorder, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, Parkinson disease, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, allergic disease, multiple sclerosis, skin basal cell carcinoma, childhood onset asthma, colorectal cancer, Lynch syndrome, Wilms tumor, prune belly syndrome, Adams-Oliver syndrome, Acropectorovertebral dysplasia, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency, Tietz syndrome, autosomal dominant Alport syndrome, Townes-Brocks syndrome, atelosteogenesis type III, Osebold-Remondini syndrome, brachydactyly type C, autosomal dominant brachyolmia, Gordon syndrome, breast cancer, chondrocalcinosis 2, congenital contractural arachnodactyly, fleck corneal dystrophy, Duane retraction syndrome, Leri-Weill dyschondrosteosis, Beckwith-Wiedemann syndrome, esophageal cancer, autoinflammatory syndrome, familial, X-linked, Behcet-like 2, immunodeficiency 98 with autoinflammation, X-linked, metastatic malignant neoplasm, granulomatous disease, chronic, autosomal recessive, 5, hyper-IgE recurrent infection syndrome 5, autosomal recessive, immunodeficiency 81, immunodeficiency 82 with systemic inflammation, inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive, immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias, immunodeficiency 75, immunodeficiency 76, nephrotic syndrome 16, immunodeficiency 69, immunodeficiency 78 with autoimmunity and developmental delay, immunodeficiency 70, immunodeficiency 72 with autoinflammation, immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia, autoinflammation, immune dysregulation, and eosinophilia, severe combined immunodeficiency due to CD70 deficiency, myofibroblastoma, invasive carcinoma, adenoviridae infectious disease, brain injury, nosocomial infection, enteritis, ulcer disease, radiation pneumonitis, familial adenomatous polyposis 4, severe combined immunodeficiency due to LAT deficiency, desmoplastic melanoma, myelofibrosis, salivary duct carcinoma, oral cavity carcinoma, rectal carcinoma, vertebral disorder, digestive system melanoma, short-rib thoracic dysplasia 17 with or without polydactyly, platelet abnormalities with eosinophilia and immune-mediated inflammatory disease, COVID-19, liver failure, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, spondyloepimetaphyseal dysplasia, gastrointestinal defects and immunodeficiency syndrome 1, immunodeficiency 105, autoinflammatory disease, X-linked, autoinflammatory syndrome with immunodeficiency, achalasia-alacrima syndrome, choroidal neovascularization, rhizomelic dysplasia, Ain-Naz type, autoinflammatory disease, multisystem, with immune dysregulation, X-linked, hyper-IgE syndrome 6, autosomal dominant, with recurrent infections, immunodeficiency 113 with autoimmunity and autoinflammation, immunodeficiency 117, neutropenia, severe congenital, 11, autosomal dominant, autoinflammation with episodic fever and immune dysregulation, immunodeficiency 119, postmenopausal osteoporosis, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, ankylosing spondylitis, deep vein thrombosis, angina pectoris, atherosclerosis, necrotizing enterocolitis, gastroesophageal reflux disease, seasonal allergic rhinitis, breast neoplasm, left ventricular hypertrophy, stomach neoplasm, obstructive sleep apnea, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, neuropathy, open-angle glaucoma, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Vitiligo, hypospadias, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, exfoliation syndrome, focal segmental glomerulosclerosis, chronic hepatitis B virus infection, interstitial lung disease, mucocutaneous lymph node syndrome, meningococcal infection, membranous glomerulonephritis, nephrotic syndrome, osteonecrosis, bone disease, vascular disease, peripheral arterial disease, sclerosing cholangitis, scoliosis, brain infarction, thoracic aortic aneurysm, ventricular fibrillation, colonic neoplasm, erythrocyte count, platelet count, vital capacity, forced expiratory volume, smoking behavior, body weight, body mass index, body fat distribution, waist-hip ratio, corneal topography, neuroimaging measurement, metastatic neoplasm, wheezing, enthesitis-related juvenile idiopathic arthritis, Chronic Obstructive Asthma, carotid atherosclerosis, pulse wave reflection index measurement, total hip arthroplasty, kidney injury, muscle atrophy, chromosomal aberration frequency, bone metastasis, HMG CoA reductase inhibitor use measurement, Inhalant adrenergic use measurement, Glucocorticoid use measurement, low density lipoprotein triglyceride measurement, diverticular disease, corneal resistance factor, citrate measurement, cholesteryl ester measurement, glucuronate measurement, isocitrate measurement, atopic asthma, coinfection, total joint arthroplasty, aspartate aminotransferase to alanine aminotransferase ratio, nephrotoxicity, inflammatory bowel disease, immunodeficiency, and encephalopathy, severe malarial anemia, total knee arthroplasty, palmitate 16:0 measurement, sexual dimorphism measurement, body surface area, serum lipopolysaccharide activity, Birt-Hogg-Dube syndrome, 25-hydroxyvitamin D3 measurement, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, granulosa cell tumor, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, pulmonary tuberculosis, tongue squamous cell carcinoma, nasopharyngeal squamous cell carcinoma, Acute Leukemia, Ampulla of Vater Carcinoma, Appendix Adenocarcinoma, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Cavernous Hemangioma, Central Nervous System Lymphoma, Cervical Adenosquamous Carcinoma, cervical squamous cell carcinoma, Colon Dysplasia, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Undifferentiated Carcinoma, Fibroblastic Neoplasm, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, nonpapillary renal cell carcinoma, Pallister-Hall syndrome, periodic fever, immunodeficiency, and thrombocytopenia syndrome, platyspondylic dysplasia, Torrance type, systemic lupus erythematosus, Marfan syndrome, melorheostosis, mesomelic dysplasia, Kantaputra type, metatropic dysplasia, Mobius syndrome, Muir-Torre syndrome, Cowden syndrome 1, myotonic dystrophy type 1, nail-patella syndrome, autosomal dominant progressive nephropathy with hypertension, ovarian cancer, Peyronie disease, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, Hutchinson-Gilford progeria syndrome, familial juvenile hyperuricemic nephropathy type 1, Peutz-Jeghers syndrome, prostate cancer, pseudoachondroplasia, autosomal dominant distal renal tubular acidosis, retinoblastoma, Smith-Magenis syndrome, spondyloepiphyseal dysplasia tarda, autosomal dominant, spondyloepimetaphyseal dysplasia, Strudwick type, spondylometaphyseal dysplasia, Kozlowski type, spondylometaphyseal dysplasia, Schmidt type, proximal symphalangism, syndactyly type 5, brachydactyly-elbow wrist dysplasia syndrome, tarsal-carpal coalition syndrome, thoracolaryngopelvic dysplasia, tooth and nail syndrome, volvulus of midgut, short-limb skeletal dysplasia with severe combined immunodeficiency, acrocallosal syndrome, acrodermatitis enteropathica, acromesomelic dysplasia 2C, Hunter-Thompson type, agnathia-otocephaly complex, autosomal recessive Alport syndrome, amelogenesis imperfecta type 1G, microphthalmia with limb anomalies, progressive pseudorheumatoid arthropathy of childhood, Bloom syndrome, kyphomelic dysplasia, lung cancer, heart defects-limb shortening syndrome, chordoma, Juberg-Hayward syndrome, Costello syndrome, cystic fibrosis, hereditary renal hypouricemia, diastrophic dysplasia, Dyggve-Melchior-Clausen disease, Ehlers-Danlos syndrome, dermatosparaxis type, multiple epiphyseal dysplasia type 4, classic Hodgkin lymphoma, immunodeficiency, common variable, 2, ichthyosis-intellectual disability-dwarfism-renal impairment syndrome, Nezelof syndrome, spondylometaphyseal dysplasia, Sedaghatian type, metaphyseal dysostosis-intellectual disability-conductive deafness syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, carnitine palmitoyl transferase II deficiency, myopathic form, Schwartz-Jampel syndrome, Leigh syndrome, nail-patella-like renal disease, nephronophthisis 1, congenital nephrotic syndrome, Finnish type, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, human papilloma virus infection, fibrosarcoma, benign neoplasm, hypertrophy, anaplastic astrocytoma, cardiac hypertrophy, medical procedure, AIDS dementia, juvenile idiopathic arthritis, insulin resistance, prostate intraepithelial neoplasia, septic peritonitis, vulvar intraepithelial neoplasia, renal carcinoma, thyroid carcinoma, metastatic melanoma, pancreatic carcinoma, rotavirus infection, Cutaneous T-cell lymphoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, muscular disease, transitional cell carcinoma of kidney, anaplastic large cell lymphoma, bacteriemia, hepatitis C virus infection, non-small cell lung carcinoma, kidney disease, non-alcoholic fatty liver disease, peripheral neuropathy, testicular seminoma, pneumonia, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, refractory anemia with ringed sideroblasts, laryngeal neoplasm, lung disease, brain neoplasm, calcification, retinopathy, thyroid neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD3 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'breast': 0, 'atrium auricular region': 1, 'liver': 0, 'skeletal muscle tissue': 1, 'EBV-transformed lymphocyte': 0, 'esophagus mucosa': 1, 'macrophage': -1, 'adipose tissue': 0, 'segmented neutrophil of bone marrow': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': -1, 'class switched memory B cell': 0, 'CD14-positive, CD16-negative classical monocyte': 3, 'Brodmann (1909) area 9': 0, 'CD4-positive, alpha-beta thymocyte': 1, 'zone of skin': 1, 'leukocyte': 0, 'nasopharynx': -1, 'tonsil': 0, 'frontal lobe': 0, 'cerebellar hemisphere': -1, 'putamen': 0, 'hematopoietic stem cell': -1, 'effector memory CD4-positive, alpha-beta T cell': 0, 'testis': -1, 'bronchus': -1, 'sigmoid colon': 0, 'fallopian tube': 0, 'plasma cell': -1, 'aorta': 0, 'adrenal gland': -1, 'kidney': 0, 'endometrium': 0, 'smooth muscle tissue': 0, 'tibial artery': 0, 'prefrontal cortex': 0, 'CD8-positive, alpha-beta T cell': -1, 'vermiform appendix': 0, 'lymph node': 0, 'duodenum': 0, 'mature eosinophil': 0, 'prostate gland': 1, 'C1 segment of cervical spinal cord': -1, 'lung': 0, 'inflammatory macrophage': -1, 'rectum': 0, 'suprapubic skin': 0, 'brain': -1, 'coronary artery': 0, 'parathyroid gland': -1, 'Brodmann (1909) area 24': 0, 'esophagus muscularis mucosa': 0, 'esophagus': 1, 'transformed skin fibroblast': 1, 'heart muscle': -1, 'pancreas': 0, 'uterus': 0, 'placenta': 0, 'seminal vesicle': -1, 'hippocampus': -1, 'effector memory CD8-positive, alpha-beta T cell': 0, 'endothelial cell of umbilical vein (resting)': 0, 'minor salivary gland': 0, 'endocervix': 1, 'central memory CD8-positive, alpha-beta T cell': 0, 'CD8-positive, alpha-beta thymocyte': -1, 'granulocyte monocyte progenitor cell': -1, 'caudate nucleus': 0, 'amygdala': 0, 'temporal lobe': 0, 'substantia nigra': -1, 'abdomen': -1, 'common lymphoid progenitor': 0, 'cerebral cortex': 0, 'endothelial cell of umbilical vein (proliferating)': 0, 'blood': -1, 'nucleus accumbens': 0, 'stomach': 0, 'oral mucosa': -1, 'mature neutrophil': 0, 'central memory CD4-positive, alpha-beta T cell': 0, 'bone marrow': -1, 'gall bladder': 1, 'colon': 0, 'cytotoxic CD56-dim natural killer cell': -1, 'pituitary gland': 0, 'transverse colon': 0, 'heart left ventricle': 0, 'erythroblast': -1, 'vagina': 1, 'ovary': 1, 'megakaryocyte-erythroid progenitor cell': -1, 'subcutaneous adipose tissue': 1, 'cerebellum': -1, 'hypothalamus': -1, 'common myeloid progenitor': -1, 'hematopoietic multipotent progenitor cell': -1, 'alternatively activated macrophage': -1, 'thyroid gland': 1, 'lower leg skin': 0, 'epididymis': -1, 'spleen': 0, 'esophagogastric junction': 0, 'greater omentum': 1, 'memory B cell': 0, 'hippocampus proper': -1, 'CD4-positive, alpha-beta T cell': -1, 'small intestine': 1, 'conventional dendritic cell': -1, 'cortex of kidney': 0, \\\"small intestine Peyer's patch\\\": 0, 'heart': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': -1, 'caudate-putamen': -1, 'urinary bladder': 1, 'ectocervix': 1, 'regulatory T cell': -1, 'CD38-negative naive B cell': 1, 'saliva-secreting gland': 0, 'neutrophilic metamyelocyte': -1, 'tibial nerve': 0}. *OpenTargets: SMAD3 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): -0.12650999426841736 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.360300064086914 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD3; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.9999799728393555\\n• *GO: SMAD3 representative GO terms: C:ciliary basal body, C:intracellular membrane-bounded organelle, C:plasma membrane, C:nucleus, C:chromatin, C:transcription regulator complex, F:protein homodimerization activity, F:co-SMAD binding, F:DNA-binding transcription activator activity, RNA polymerase II-specific, F:chromatin DNA binding, F:RNA polymerase II cis-regulatory region sequence-specific DNA binding, F:sterol response element binding, P:embryonic pattern specification, P:positive regulation of transforming growth factor beta3 production, P:primary miRNA processing, P:response to hypoxia, P:regulation of striated muscle tissue development, P:wound healing.\"],[\"20251224-191245_ui/genes/SMAD3/transcripts.tsv\",\"transcript_id\\tn_exons\\tname\\tstatus\\taliases\\tlocations\\tnotes\\tsource\\r\\ngeneral_localization\\t\\tgeneral_localization\\t\\t\\tCytoplasm,Nucleus\\tCytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Co-localizes with LEMD3 at the nucleus inner membrane . MAPK-mediated phosphorylation appears to have no effect on nuclear import . PDPK1 prevents its nuclear translocation in response to TGF-beta . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity)\\tisoforms\\r\\n\"],[\"20251224-191245_ui/genes/SMAD2/interactions_nonhuman.tsv\",\"experiment_type\\tpartner_symbol\\r\\nAffinity Capture-Luminescence\\tARHGEF1\\r\\nAffinity Capture-Luminescence\\tARHGEF6\\r\\nAffinity Capture-Luminescence\\tARHGEF7\\r\\nAffinity Capture-Luminescence\\tARL4D\\r\\nAffinity Capture-Luminescence\\tCDC40\\r\\nAffinity Capture-Luminescence\\tFBXO3\\r\\nAffinity Capture-Luminescence\\tIRAK2\\r\\nAffinity Capture-Luminescence\\tLHX9\\r\\nAffinity Capture-Luminescence\\tLMO2\\r\\nAffinity Capture-Luminescence\\tMAP2K3\\r\\nAffinity Capture-Luminescence\\tNUAK2\\r\\nAffinity Capture-Luminescence\\tPPP2R2D\\r\\nAffinity Capture-Luminescence\\tRAB34\\r\\nAffinity Capture-Luminescence\\tRAB38\\r\\nAffinity Capture-Luminescence\\tRASD2\\r\\nAffinity Capture-Luminescence\\tRGS3\\r\\nAffinity Capture-Luminescence\\tRHEBL1\\r\\nAffinity Capture-Luminescence\\tRHOBTB1\\r\\nAffinity Capture-Luminescence\\tRHOD\\r\\nAffinity Capture-Luminescence\\tRHOJ\\r\\nAffinity Capture-Luminescence\\tRPS27A\\r\\nAffinity Capture-Luminescence\\tSMAD2\\r\\nAffinity Capture-Luminescence\\tSMAD3\\r\\nAffinity Capture-Luminescence\\tSQSTM1\\r\\nAffinity Capture-Luminescence\\tTRIM35\\r\\nAffinity Capture-Luminescence\\tUHMK1\\r\\nAffinity Capture-Luminescence\\tWWP2\\r\\nAffinity Capture-MS\\tALDH4A1\\r\\nAffinity Capture-MS\\tBACH1\\r\\nAffinity Capture-MS\\tE6\\r\\nAffinity Capture-MS\\tFANCD2\\r\\nAffinity Capture-MS\\tNSP16AB\\r\\nAffinity Capture-MS\\tOTUB1\\r\\nAffinity Capture-MS\\tPAXIP1\\r\\nAffinity Capture-MS\\tRUNX1\\r\\nAffinity Capture-Western\\tCOL1A1\\r\\nAffinity Capture-Western\\tCOL3A1\\r\\nAffinity Capture-Western\\tCOL5A1\\r\\nAffinity Capture-Western\\tDOK1\\r\\nAffinity Capture-Western\\tE6\\r\\nAffinity Capture-Western\\tE7\\r\\nAffinity Capture-Western\\tGATA4\\r\\nAffinity Capture-Western\\tHCVGP1\\r\\nAffinity Capture-Western\\tKAP-ALPHA3\\r\\nAffinity Capture-Western\\tKLF4\\r\\nAffinity Capture-Western\\tLEF1\\r\\nAffinity Capture-Western\\tMED\\r\\nAffinity Capture-Western\\tMED15\\r\\nAffinity Capture-Western\\tMEF2A\\r\\nAffinity Capture-Western\\tRNF111\\r\\nAffinity Capture-Western\\tSKI\\r\\nAffinity Capture-Western\\tSMAD2\\r\\nAffinity Capture-Western\\tSMAD4\\r\\nAffinity Capture-Western\\tSMOX\\r\\nAffinity Capture-Western\\tSNOO\\r\\nAffinity Capture-Western\\tUBX\\r\\nAffinity Capture-Western\\tVIS\\r\\nAffinity Capture-Western\\tWWTR1\\r\\nAffinity Capture-Western\\tYAP1\\r\\nCo-localization\\tE7\\r\\nCo-localization\\tEZH2-A\\r\\nCo-localization\\tKLF4\\r\\nPCA\\tE6\\r\\nPCA\\tSMOX\\r\\nPhenotypic Enhancement\\tBABO\\r\\nPhenotypic Enhancement\\tINR\\r\\nPhenotypic Enhancement\\tSMOX\\r\\nPhenotypic Enhancement\\tYKI\\r\\nPhenotypic Suppression\\tBABO\\r\\nPhenotypic Suppression\\tHPO\\r\\nPhenotypic Suppression\\tINR\\r\\nPhenotypic Suppression\\tMYO\\r\\nPhenotypic Suppression\\tPLUM\\r\\nPhenotypic Suppression\\tPTEN\\r\\nPhenotypic Suppression\\tSCGDELTA\\r\\nPhenotypic Suppression\\tSMOX\\r\\nReconstituted Complex\\tE7\\r\\nReconstituted Complex\\tLEMD3\\r\\nReconstituted Complex\\tSMAD2\\r\\nReconstituted Complex\\tSOX9\\r\\nReconstituted Complex\\tUBX\\r\\nReconstituted Complex\\tZFP128\\r\\nTwo-hybrid\\tCG18095\\r\\nTwo-hybrid\\tD\\r\\nTwo-hybrid\\tE6\\r\\nTwo-hybrid\\tEG\\r\\nTwo-hybrid\\tFOXH1\\r\\nTwo-hybrid\\tHOXA13\\r\\nTwo-hybrid\\tHOXD13\\r\\nTwo-hybrid\\tHR78\\r\\nTwo-hybrid\\tSMAD2\\r\\nTwo-hybrid\\tSMOX\\r\\nTwo-hybrid\\tUBX\\r\\nTwo-hybrid\\tZEB2\\r\\nTwo-hybrid\\tZEN\\r\\n\"],[\"20251224-191245_ui/genes/SMAD2/interactions_human.tsv\",\"experiment_type\\tpartner_symbol\\r\\nAffinity Capture-Luminescence\\tSMAD3\\r\\nAffinity Capture-Luminescence\\tSMAD4\\r\\nAffinity Capture-Luminescence\\tSMURF2\\r\\nAffinity Capture-MS\\tARID1A\\r\\nAffinity Capture-MS\\tARID1B\\r\\nAffinity Capture-MS\\tASH2L\\r\\nAffinity Capture-MS\\tATAD3B\\r\\nAffinity Capture-MS\\tBCL7A\\r\\nAffinity Capture-MS\\tBTBD9\\r\\nAffinity Capture-MS\\tBUB3\\r\\nAffinity Capture-MS\\tC1ORF116\\r\\nAffinity Capture-MS\\tCAD\\r\\nAffinity Capture-MS\\tCCT6A\\r\\nAffinity Capture-MS\\tCDC27\\r\\nAffinity Capture-MS\\tCGA\\r\\nAffinity Capture-MS\\tCPSF7\\r\\nAffinity Capture-MS\\tCREBBP\\r\\nAffinity Capture-MS\\tCSNK1D\\r\\nAffinity Capture-MS\\tCTNNB1\\r\\nAffinity Capture-MS\\tCUL4A\\r\\nAffinity Capture-MS\\tCUL4B\\r\\nAffinity Capture-MS\\tDCAF7\\r\\nAffinity Capture-MS\\tDDX3Y\\r\\nAffinity Capture-MS\\tDGKA\\r\\nAffinity Capture-MS\\tDHX8\\r\\nAffinity Capture-MS\\tDNAJA2\\r\\nAffinity Capture-MS\\tDOCK9\\r\\nAffinity Capture-MS\\tDYRK1A\\r\\nAffinity Capture-MS\\tEPB41L5\\r\\nAffinity Capture-MS\\tERBB2IP\\r\\nAffinity Capture-MS\\tEZH2\\r\\nAffinity Capture-MS\\tFAM83G\\r\\nAffinity Capture-MS\\tFLOT1\\r\\nAffinity Capture-MS\\tFLOT2\\r\\nAffinity Capture-MS\\tFYN\\r\\nAffinity Capture-MS\\tGSK3A\\r\\nAffinity Capture-MS\\tGTF3C2\\r\\nAffinity Capture-MS\\tGTF3C6\\r\\nAffinity Capture-MS\\tHCFC1\\r\\nAffinity Capture-MS\\tHDAC2\\r\\nAffinity Capture-MS\\tHDAC4\\r\\nAffinity Capture-MS\\tHINT3\\r\\nAffinity Capture-MS\\tHSPA4\\r\\nAffinity Capture-MS\\tITGB4\\r\\nAffinity Capture-MS\\tKLF5\\r\\nAffinity Capture-MS\\tKMT2C\\r\\nAffinity Capture-MS\\tLDLRAD4\\r\\nAffinity Capture-MS\\tLEMD3\\r\\nAffinity Capture-MS\\tMED15\\r\\nAffinity Capture-MS\\tMED16\\r\\nAffinity Capture-MS\\tMED17\\r\\nAffinity Capture-MS\\tMED19\\r\\nAffinity Capture-MS\\tMED20\\r\\nAffinity Capture-MS\\tMED22\\r\\nAffinity Capture-MS\\tMED25\\r\\nAffinity Capture-MS\\tMED31\\r\\nAffinity Capture-MS\\tMED4\\r\\nAffinity Capture-MS\\tMED9\\r\\nAffinity Capture-MS\\tMEN1\\r\\nAffinity Capture-MS\\tMTMR4\\r\\nAffinity Capture-MS\\tNCOA3\\r\\nAffinity Capture-MS\\tOGT\\r\\nAffinity Capture-MS\\tOPA1\\r\\nAffinity Capture-MS\\tOTUB1\\r\\nAffinity Capture-MS\\tPARK2\\r\\nAffinity Capture-MS\\tPCBP1\\r\\nAffinity Capture-MS\\tPCID2\\r\\nAffinity Capture-MS\\tPLEKHA4\\r\\nAffinity Capture-MS\\tPSPC1\\r\\nAffinity Capture-MS\\tRIN1\\r\\nAffinity Capture-MS\\tSGSH\\r\\nAffinity Capture-MS\\tSIK3\\r\\nAffinity Capture-MS\\tSKI\\r\\nAffinity Capture-MS\\tSKIL\\r\\nAffinity Capture-MS\\tSLC25A3\\r\\nAffinity Capture-MS\\tSLC25A5\\r\\nAffinity Capture-MS\\tSLC25A6\\r\\nAffinity Capture-MS\\tSMAD1\\r\\nAffinity Capture-MS\\tSMAD3\\r\\nAffinity Capture-MS\\tSMAD4\\r\\nAffinity Capture-MS\\tSMAD5\\r\\nAffinity Capture-MS\\tSMAD9\\r\\nAffinity Capture-MS\\tSMARCA4\\r\\nAffinity Capture-MS\\tSMARCC1\\r\\nAffinity Capture-MS\\tSMARCC2\\r\\nAffinity Capture-MS\\tSMARCD2\\r\\nAffinity Capture-MS\\tSMPDL3B\\r\\nAffinity Capture-MS\\tSMURF2\\r\\nAffinity Capture-MS\\tSNW1\\r\\nAffinity Capture-MS\\tSNX27\\r\\nAffinity Capture-MS\\tSQRDL\\r\\nAffinity Capture-MS\\tTAF1\\r\\nAffinity Capture-MS\\tTAF2\\r\\nAffinity Capture-MS\\tTAF3\\r\\nAffinity Capture-MS\\tTAF5\\r\\nAffinity Capture-MS\\tTAF6\\r\\nAffinity Capture-MS\\tTMED8\\r\\nAffinity Capture-MS\\tTMOD1\\r\\nAffinity Capture-MS\\tTRIM28\\r\\nAffinity Capture-MS\\tTRIM33\\r\\nAffinity Capture-MS\\tTRIM67\\r\\nAffinity Capture-MS\\tU2AF2\\r\\nAffinity Capture-MS\\tWDR82\\r\\nAffinity Capture-MS\\tWRNIP1\\r\\nAffinity Capture-MS\\tWWP2\\r\\nAffinity Capture-MS\\tYAF2\\r\\nAffinity Capture-MS\\tYY1\\r\\nAffinity Capture-MS\\tZFYVE9\\r\\nAffinity Capture-RNA\\tDDX58\\r\\nAffinity Capture-RNA\\tELAVL1\\r\\nAffinity Capture-Western\\tACVR1B\\r\\nAffinity Capture-Western\\tACVR2B\\r\\nAffinity Capture-Western\\tAKT1\\r\\nAffinity Capture-Western\\tANAPC10\\r\\nAffinity Capture-Western\\tATF3\\r\\nAffinity Capture-Western\\tBRCA2\\r\\nAffinity Capture-Western\\tCDC16\\r\\nAffinity Capture-Western\\tCDC27\\r\\nAffinity Capture-Western\\tCHUK\\r\\nAffinity Capture-Western\\tCITED2\\r\\nAffinity Capture-Western\\tCREBBP\\r\\nAffinity Capture-Western\\tCSNK1D\\r\\nAffinity Capture-Western\\tCTNNB1\\r\\nAffinity Capture-Western\\tDAB2\\r\\nAffinity Capture-Western\\tDOCK9\\r\\nAffinity Capture-Western\\tEID2\\r\\nAffinity Capture-Western\\tELAC2\\r\\nAffinity Capture-Western\\tEP300\\r\\nAffinity Capture-Western\\tERBB2IP\\r\\nAffinity Capture-Western\\tESR1\\r\\nAffinity Capture-Western\\tETV4\\r\\nAffinity Capture-Western\\tEZH2\\r\\nAffinity Capture-Western\\tFHL1\\r\\nAffinity Capture-Western\\tFHL2\\r\\nAffinity Capture-Western\\tFHL3\\r\\nAffinity Capture-Western\\tFOXH1\\r\\nAffinity Capture-Western\\tFOXP1\\r\\nAffinity Capture-Western\\tGLI1\\r\\nAffinity Capture-Western\\tGTF2I\\r\\nAffinity Capture-Western\\tGTF2IRD1\\r\\nAffinity Capture-Western\\tHDAC1\\r\\nAffinity Capture-Western\\tHGS\\r\\nAffinity Capture-Western\\tHYAL2\\r\\nAffinity Capture-Western\\tING2\\r\\nAffinity Capture-Western\\tINSR\\r\\nAffinity Capture-Western\\tIRF3\\r\\nAffinity Capture-Western\\tIRF7\\r\\nAffinity Capture-Western\\tITCH\\r\\nAffinity Capture-Western\\tJUN\\r\\nAffinity Capture-Western\\tKAT2A\\r\\nAffinity Capture-Western\\tKAT2B\\r\\nAffinity Capture-Western\\tKDM6B\\r\\nAffinity Capture-Western\\tKLF5\\r\\nAffinity Capture-Western\\tLEF1\\r\\nAffinity Capture-Western\\tMAPT\\r\\nAffinity Capture-Western\\tMED15\\r\\nAffinity Capture-Western\\tMED24\\r\\nAffinity Capture-Western\\tMED6\\r\\nAffinity Capture-Western\\tMEF2A\\r\\nAffinity Capture-Western\\tMETTL14\\r\\nAffinity Capture-Western\\tMETTL3\\r\\nAffinity Capture-Western\\tMYC\\r\\nAffinity Capture-Western\\tNEDD4\\r\\nAffinity Capture-Western\\tNEDD4L\\r\\nAffinity Capture-Western\\tNEDD9\\r\\nAffinity Capture-Western\\tNFYC\\r\\nAffinity Capture-Western\\tNOTCH4\\r\\nAffinity Capture-Western\\tNUP214\\r\\nAffinity Capture-Western\\tOTUB1\\r\\nAffinity Capture-Western\\tOVOL2\\r\\nAffinity Capture-Western\\tPIAS3\\r\\nAffinity Capture-Western\\tPIAS4\\r\\nAffinity Capture-Western\\tPIN1\\r\\nAffinity Capture-Western\\tPML\\r\\nAffinity Capture-Western\\tPRDM16\\r\\nAffinity Capture-Western\\tRBBP5\\r\\nAffinity Capture-Western\\tRELB\\r\\nAffinity Capture-Western\\tRGCC\\r\\nAffinity Capture-Western\\tRNF111\\r\\nAffinity Capture-Western\\tRUNX1\\r\\nAffinity Capture-Western\\tRUNX2\\r\\nAffinity Capture-Western\\tRUNX3\\r\\nAffinity Capture-Western\\tS100A4\\r\\nAffinity Capture-Western\\tSH2D2A\\r\\nAffinity Capture-Western\\tSKI\\r\\nAffinity Capture-Western\\tSKIL\\r\\nAffinity Capture-Western\\tSMAD2\\r\\nAffinity Capture-Western\\tSMAD3\\r\\nAffinity Capture-Western\\tSMAD4\\r\\nAffinity Capture-Western\\tSMAD6\\r\\nAffinity Capture-Western\\tSMAD7\\r\\nAffinity Capture-Western\\tSMARCA4\\r\\nAffinity Capture-Western\\tSMURF1\\r\\nAffinity Capture-Western\\tSMURF2\\r\\nAffinity Capture-Western\\tSOX9\\r\\nAffinity Capture-Western\\tSP1\\r\\nAffinity Capture-Western\\tSPTBN1\\r\\nAffinity Capture-Western\\tSTRAP\\r\\nAffinity Capture-Western\\tTCF12\\r\\nAffinity Capture-Western\\tTGFBR1\\r\\nAffinity Capture-Western\\tTGFBR2\\r\\nAffinity Capture-Western\\tTGIF1\\r\\nAffinity Capture-Western\\tTP53\\r\\nAffinity Capture-Western\\tTRIM28\\r\\nAffinity Capture-Western\\tTRIM33\\r\\nAffinity Capture-Western\\tTSC2\\r\\nAffinity Capture-Western\\tUCHL1\\r\\nAffinity Capture-Western\\tUSP15\\r\\nAffinity Capture-Western\\tUSP2\\r\\nAffinity Capture-Western\\tUSP7\\r\\nAffinity Capture-Western\\tUSP9X\\r\\nAffinity Capture-Western\\tWWP1\\r\\nAffinity Capture-Western\\tWWP2\\r\\nAffinity Capture-Western\\tYAP1\\r\\nAffinity Capture-Western\\tZEB1\\r\\nAffinity Capture-Western\\tZFYVE9\\r\\nBiochemical Activity\\tACVR1B\\r\\nBiochemical Activity\\tCAMK2G\\r\\nBiochemical Activity\\tCDK2\\r\\nBiochemical Activity\\tCDK4\\r\\nBiochemical Activity\\tCDK8\\r\\nBiochemical Activity\\tCDK9\\r\\nBiochemical Activity\\tCSNK1D\\r\\nBiochemical Activity\\tITCH\\r\\nBiochemical Activity\\tTGFBR1\\r\\nCo-crystal Structure\\tSMAD4\\r\\nCo-fractionation\\tAP1M1\\r\\nCo-fractionation\\tARID1B\\r\\nCo-fractionation\\tCAV1\\r\\nCo-fractionation\\tCREBBP\\r\\nCo-fractionation\\tCTNNB1\\r\\nCo-fractionation\\tHDAC1\\r\\nCo-fractionation\\tHMGA2\\r\\nCo-fractionation\\tMTA2\\r\\nCo-fractionation\\tNAA15\\r\\nCo-fractionation\\tNCOA3\\r\\nCo-fractionation\\tPARP1\\r\\nCo-fractionation\\tPML\\r\\nCo-fractionation\\tPRKDC\\r\\nCo-fractionation\\tRBM14\\r\\nCo-fractionation\\tRELA\\r\\nCo-fractionation\\tSMAD3\\r\\nCo-fractionation\\tSMAD4\\r\\nCo-fractionation\\tSMARCA4\\r\\nCo-fractionation\\tSMARCC1\\r\\nCo-fractionation\\tSMARCC2\\r\\nCo-fractionation\\tSNF8\\r\\nCo-fractionation\\tSUB1\\r\\nCo-fractionation\\tTGFBR1\\r\\nCo-fractionation\\tTRIM33\\r\\nCo-fractionation\\tXRCC6\\r\\nCo-fractionation\\tZFYVE9\\r\\nCo-localization\\tCAMK2A\\r\\nCo-localization\\tTGFBR1\\r\\nCo-localization\\tTP53\\r\\nFRET\\tBECN1\\r\\nFRET\\tLATS2\\r\\nFRET\\tMYC\\r\\nFRET\\tSMAD1\\r\\nPhenotypic Enhancement\\tSMAD3\\r\\nPhenotypic Enhancement\\tSNW1\\r\\nPhenotypic Suppression\\tSMAD7\\r\\nPhenotypic Suppression\\tSTRAP\\r\\nPositive Genetic\\tSPPL3\\r\\nProximity Label-MS\\tCCNF\\r\\nProximity Label-MS\\tEPHA2\\r\\nProximity Label-MS\\tOPTN\\r\\nProximity Label-MS\\tRAB7A\\r\\nProximity Label-MS\\tSNCA\\r\\nProximity Label-MS\\tTGOLN2\\r\\nReconstituted Complex\\tANAPC10\\r\\nReconstituted Complex\\tANP32B\\r\\nReconstituted Complex\\tANP32E\\r\\nReconstituted Complex\\tATP5I\\r\\nReconstituted Complex\\tBPTF\\r\\nReconstituted Complex\\tCREBBP\\r\\nReconstituted Complex\\tDAB2\\r\\nReconstituted Complex\\tDVL1\\r\\nReconstituted Complex\\tELAC2\\r\\nReconstituted Complex\\tERBB2IP\\r\\nReconstituted Complex\\tESR1\\r\\nReconstituted Complex\\tFHL1\\r\\nReconstituted Complex\\tFHL2\\r\\nReconstituted Complex\\tFHL3\\r\\nReconstituted Complex\\tFOXH1\\r\\nReconstituted Complex\\tHDAC2\\r\\nReconstituted Complex\\tHIPK2\\r\\nReconstituted Complex\\tHYAL2\\r\\nReconstituted Complex\\tINSR\\r\\nReconstituted Complex\\tIRF7\\r\\nReconstituted Complex\\tJUN\\r\\nReconstituted Complex\\tKAT2B\\r\\nReconstituted Complex\\tLCK\\r\\nReconstituted Complex\\tLEF1\\r\\nReconstituted Complex\\tMECOM\\r\\nReconstituted Complex\\tMEF2A\\r\\nReconstituted Complex\\tMEF2C\\r\\nReconstituted Complex\\tMYC\\r\\nReconstituted Complex\\tMYOCD\\r\\nReconstituted Complex\\tNEDD4L\\r\\nReconstituted Complex\\tNEFM\\r\\nReconstituted Complex\\tNFIA\\r\\nReconstituted Complex\\tNUP214\\r\\nReconstituted Complex\\tOTUB1\\r\\nReconstituted Complex\\tPARD3\\r\\nReconstituted Complex\\tPIAS3\\r\\nReconstituted Complex\\tPIK3CA\\r\\nReconstituted Complex\\tPIN1\\r\\nReconstituted Complex\\tPTMS\\r\\nReconstituted Complex\\tRHOA\\r\\nReconstituted Complex\\tSH2D2A\\r\\nReconstituted Complex\\tSKI\\r\\nReconstituted Complex\\tSMAD4\\r\\nReconstituted Complex\\tSMAD7\\r\\nReconstituted Complex\\tSMURF2\\r\\nReconstituted Complex\\tSNW1\\r\\nReconstituted Complex\\tSOD1\\r\\nReconstituted Complex\\tSP1\\r\\nReconstituted Complex\\tSTUB1\\r\\nReconstituted Complex\\tSYT1\\r\\nReconstituted Complex\\tTP53\\r\\nReconstituted Complex\\tTUBA1B\\r\\nReconstituted Complex\\tUCHL5\\r\\nReconstituted Complex\\tYY1\\r\\nReconstituted Complex\\tZFYVE9\\r\\nTwo-hybrid\\tABTB1\\r\\nTwo-hybrid\\tAKT1\\r\\nTwo-hybrid\\tANAPC2\\r\\nTwo-hybrid\\tANK3\\r\\nTwo-hybrid\\tANTXR2\\r\\nTwo-hybrid\\tBAZ1A\\r\\nTwo-hybrid\\tBTBD2\\r\\nTwo-hybrid\\tC22ORF46\\r\\nTwo-hybrid\\tC9ORF156\\r\\nTwo-hybrid\\tCISH\\r\\nTwo-hybrid\\tCOPS5\\r\\nTwo-hybrid\\tCORO2A\\r\\nTwo-hybrid\\tCREBBP\\r\\nTwo-hybrid\\tCSH1\\r\\nTwo-hybrid\\tCSH2\\r\\nTwo-hybrid\\tCUL5\\r\\nTwo-hybrid\\tCYLC2\\r\\nTwo-hybrid\\tCYP11A1\\r\\nTwo-hybrid\\tDCUN1D1\\r\\nTwo-hybrid\\tDNAJB5\\r\\nTwo-hybrid\\tDNAJC7\\r\\nTwo-hybrid\\tDOCK8\\r\\nTwo-hybrid\\tDYNC1H1\\r\\nTwo-hybrid\\tDYRK1A\\r\\nTwo-hybrid\\tEEF1A1\\r\\nTwo-hybrid\\tEIF3L\\r\\nTwo-hybrid\\tEP300\\r\\nTwo-hybrid\\tETV4\\r\\nTwo-hybrid\\tFAM161B\\r\\nTwo-hybrid\\tFBP2\\r\\nTwo-hybrid\\tFOXH1\\r\\nTwo-hybrid\\tGATAD2B\\r\\nTwo-hybrid\\tGFER\\r\\nTwo-hybrid\\tHSD17B3\\r\\nTwo-hybrid\\tINSR\\r\\nTwo-hybrid\\tKHDRBS1\\r\\nTwo-hybrid\\tKIAA1033\\r\\nTwo-hybrid\\tKPNB1\\r\\nTwo-hybrid\\tLAMA5\\r\\nTwo-hybrid\\tLEMD3\\r\\nTwo-hybrid\\tMAP2K1\\r\\nTwo-hybrid\\tMLLT4\\r\\nTwo-hybrid\\tMYC\\r\\nTwo-hybrid\\tNAGK\\r\\nTwo-hybrid\\tNCOA6\\r\\nTwo-hybrid\\tNEDD4L\\r\\nTwo-hybrid\\tOS9\\r\\nTwo-hybrid\\tPAPOLA\\r\\nTwo-hybrid\\tPAPPA\\r\\nTwo-hybrid\\tPAXIP1\\r\\nTwo-hybrid\\tPEX19\\r\\nTwo-hybrid\\tPIAS4\\r\\nTwo-hybrid\\tPLIN3\\r\\nTwo-hybrid\\tPOU2AF1\\r\\nTwo-hybrid\\tPPP2R1A\\r\\nTwo-hybrid\\tPRKAR1A\\r\\nTwo-hybrid\\tPSAP\\r\\nTwo-hybrid\\tPSG9\\r\\nTwo-hybrid\\tPSMD11\\r\\nTwo-hybrid\\tPSMD8\\r\\nTwo-hybrid\\tRANBP6\\r\\nTwo-hybrid\\tRANBP9\\r\\nTwo-hybrid\\tRARB\\r\\nTwo-hybrid\\tRASA1\\r\\nTwo-hybrid\\tRNF123\\r\\nTwo-hybrid\\tRNPC3\\r\\nTwo-hybrid\\tROCK1\\r\\nTwo-hybrid\\tRPS14\\r\\nTwo-hybrid\\tRPS27A\\r\\nTwo-hybrid\\tRXRA\\r\\nTwo-hybrid\\tSKI\\r\\nTwo-hybrid\\tSKIL\\r\\nTwo-hybrid\\tSMAD1\\r\\nTwo-hybrid\\tSMAD2\\r\\nTwo-hybrid\\tSMAD3\\r\\nTwo-hybrid\\tSMAD4\\r\\nTwo-hybrid\\tSMAD9\\r\\nTwo-hybrid\\tSMURF1\\r\\nTwo-hybrid\\tSMURF2\\r\\nTwo-hybrid\\tSNAPIN\\r\\nTwo-hybrid\\tSNIP1\\r\\nTwo-hybrid\\tSNRNP70\\r\\nTwo-hybrid\\tSNW1\\r\\nTwo-hybrid\\tSP1\\r\\nTwo-hybrid\\tSRI\\r\\nTwo-hybrid\\tST13\\r\\nTwo-hybrid\\tST5\\r\\nTwo-hybrid\\tTBC1D1\\r\\nTwo-hybrid\\tTGIF1\\r\\nTwo-hybrid\\tTGM2\\r\\nTwo-hybrid\\tTRIM62\\r\\nTwo-hybrid\\tUBA52\\r\\nTwo-hybrid\\tUBR5\\r\\nTwo-hybrid\\tXPA\\r\\nTwo-hybrid\\tZEB2\\r\\nTwo-hybrid\\tZFYVE9\\r\\nTwo-hybrid\\tZMYND11\\r\\nTwo-hybrid\\tZNF41\\r\\nTwo-hybrid\\tZNF510\\r\\nTwo-hybrid\\tZNHIT6\\r\\n\"],[\"20251224-191245_ui/genes/SMAD2/gene.json\",\"{\\n \\\"identifiers\\\": {\\n \\\"symbol\\\": \\\"SMAD2\\\",\\n \\\"entrez_id\\\": \\\"4087\\\",\\n \\\"uniprot_id\\\": \\\"Q15796\\\",\\n \\\"ensembl_id\\\": null,\\n \\\"aliases\\\": [],\\n \\\"gene_type\\\": null\\n },\\n \\\"location\\\": null,\\n \\\"annotations\\\": {\\n \\\"go_annotations\\\": [\\n \\\"C:SMAD protein complex\\\",\\n \\\"C:activin responsive factor complex\\\",\\n \\\"C:chromatin\\\",\\n \\\"C:cytoplasm\\\",\\n \\\"C:cytosol\\\",\\n \\\"C:heteromeric SMAD protein complex\\\",\\n \\\"C:homomeric SMAD protein complex\\\",\\n \\\"C:intracellular membrane-bounded organelle\\\",\\n \\\"C:nucleoplasm\\\",\\n \\\"C:nucleus\\\",\\n \\\"C:protein-containing complex\\\",\\n \\\"C:transcription regulator complex\\\",\\n \\\"F:DNA-binding transcription activator activity, RNA polymerase II-specific\\\",\\n \\\"F:DNA-binding transcription factor activity\\\",\\n \\\"F:DNA-binding transcription factor activity, RNA polymerase II-specific\\\",\\n \\\"F:DNA-binding transcription factor binding\\\",\\n \\\"F:I-SMAD binding\\\",\\n \\\"F:R-SMAD binding\\\",\\n \\\"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding\\\",\\n \\\"F:RNA polymerase II-specific DNA-binding transcription factor binding\\\",\\n \\\"F:SMAD binding\\\",\\n \\\"F:chromatin binding\\\",\\n \\\"F:cis-regulatory region sequence-specific DNA binding\\\",\\n \\\"F:co-SMAD binding\\\",\\n \\\"F:disordered domain specific binding\\\",\\n \\\"F:double-stranded DNA binding\\\",\\n \\\"F:identical protein binding\\\",\\n \\\"F:metal ion binding\\\",\\n \\\"F:phosphatase binding\\\",\\n \\\"F:tau protein binding\\\",\\n \\\"F:transforming growth factor beta receptor binding\\\",\\n \\\"F:type I transforming growth factor beta receptor binding\\\",\\n \\\"F:ubiquitin protein ligase binding\\\",\\n \\\"P:DNA-templated transcription\\\",\\n \\\"P:SMAD protein signal transduction\\\",\\n \\\"P:activin receptor signaling pathway\\\",\\n \\\"P:anatomical structure morphogenesis\\\",\\n \\\"P:anterior/posterior pattern specification\\\",\\n \\\"P:aortic valve morphogenesis\\\",\\n \\\"P:cell differentiation\\\",\\n \\\"P:cell fate commitment\\\",\\n \\\"P:cell population proliferation\\\",\\n \\\"P:determination of left/right asymmetry in lateral mesoderm\\\",\\n \\\"P:embryonic cranial skeleton morphogenesis\\\",\\n \\\"P:embryonic foregut morphogenesis\\\",\\n \\\"P:endocardial cushion morphogenesis\\\",\\n \\\"P:endoderm formation\\\",\\n \\\"P:gastrulation\\\",\\n \\\"P:in utero embryonic development\\\",\\n \\\"P:insulin secretion\\\",\\n \\\"P:intracellular signal transduction\\\",\\n \\\"P:lung development\\\",\\n \\\"P:mesoderm formation\\\",\\n \\\"P:negative regulation of DNA-templated transcription\\\",\\n \\\"P:negative regulation of cell differentiation\\\",\\n \\\"P:negative regulation of ossification\\\",\\n \\\"P:nodal signaling pathway\\\",\\n \\\"P:odontoblast differentiation\\\",\\n \\\"P:organ growth\\\",\\n \\\"P:pancreas development\\\",\\n \\\"P:paraxial mesoderm morphogenesis\\\",\\n \\\"P:pericardium development\\\",\\n \\\"P:positive regulation of BMP signaling pathway\\\",\\n \\\"P:positive regulation of DNA-templated transcription\\\",\\n \\\"P:positive regulation of epithelial to mesenchymal transition\\\",\\n \\\"P:positive regulation of gene expression\\\",\\n \\\"P:positive regulation of transcription by RNA polymerase II\\\",\\n \\\"P:post-embryonic development\\\",\\n \\\"P:primary miRNA processing\\\",\\n \\\"P:pulmonary valve morphogenesis\\\",\\n \\\"P:regulation of DNA-templated transcription\\\",\\n \\\"P:regulation of transforming growth factor beta receptor signaling pathway\\\",\\n \\\"P:response to cholesterol\\\",\\n \\\"P:response to glucose\\\",\\n \\\"P:secondary palate development\\\",\\n \\\"P:transforming growth factor beta receptor signaling pathway\\\",\\n \\\"P:trophoblast cell migration\\\",\\n \\\"P:ureteric bud development\\\",\\n \\\"P:zygotic specification of dorsal/ventral axis\\\"\\n ],\\n \\\"functions\\\": [\\n \\\"Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma\\\"\\n ],\\n \\\"diseases\\\": [\\n \\\"Congenital heart defects, multiple types, 8, with or without heterotaxy\\\",\\n \\\"Loeys-Dietz syndrome 6\\\"\\n ],\\n \\\"pathways\\\": [\\n \\\"SMAD2/3 Phosphorylation Motif Mutants in Cancer\\\",\\n \\\"Developmental Biology\\\",\\n \\\"Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer\\\",\\n \\\"Deubiquitination\\\",\\n \\\"TGF-beta receptor signaling activates SMADs\\\",\\n \\\"Signaling by TGFB family members\\\",\\n \\\"Loss of Function of TGFBR1 in Cancer\\\",\\n \\\"Signaling by TGF-beta Receptor Complex\\\",\\n \\\"TGFBR1 KD Mutants in Cancer\\\",\\n \\\"Post-translational protein modification\\\",\\n \\\"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes\\\",\\n \\\"Disease\\\",\\n \\\"Generic Transcription Pathway\\\",\\n \\\"Metabolism of proteins\\\",\\n \\\"Gene expression (Transcription)\\\",\\n \\\"Signal Transduction\\\",\\n \\\"FOXO-mediated transcription\\\",\\n \\\"Gastrulation\\\",\\n \\\"RNA Polymerase II Transcription\\\",\\n \\\"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription\\\",\\n \\\"FOXO-mediated transcription of cell cycle genes\\\",\\n \\\"Loss of Function of SMAD2/3 in Cancer\\\",\\n \\\"Transcriptional regulation of pluripotent stem cells\\\",\\n \\\"SMAD4 MH2 Domain Mutants in Cancer\\\",\\n \\\"Diseases of signal transduction by growth factor receptors and second messengers\\\",\\n \\\"Formation of axial mesoderm\\\",\\n \\\"Germ layer formation at gastrulation\\\",\\n \\\"Downregulation of TGF-beta receptor signaling\\\",\\n \\\"Formation of definitive endoderm\\\",\\n \\\"Ub-specific processing proteases\\\",\\n \\\"Loss of Function of SMAD4 in Cancer\\\",\\n \\\"Downregulation of SMAD2/3:SMAD4 transcriptional activity\\\",\\n \\\"SMAD2/3 MH2 Domain Mutants in Cancer\\\",\\n \\\"Signaling by Activin\\\",\\n \\\"Signaling by TGF-beta Receptor Complex in Cancer\\\",\\n \\\"Signaling by NODAL\\\"\\n ],\\n \\\"cell_localizations\\\": [],\\n \\\"predicted_go\\\": [\\n \\\"regulation of production of miRNAs involved in gene silencing by miRNA\\\",\\n \\\"transmembrane receptor protein serine/threonine kinase signaling pathway\\\",\\n \\\"positive regulation of transcription from RNA polymerase II promoter in response to stress\\\",\\n \\\"negative regulation of MAPK cascade\\\",\\n \\\"negative regulation of protein phosphorylation\\\",\\n \\\"negative regulation of protein modification process\\\",\\n \\\"regulation of transcription from RNA polymerase II promoter in response to stress\\\",\\n \\\"negative regulation of DNA binding transcription factor activity\\\",\\n \\\"positive regulation of pathway-restricted SMAD protein phosphorylation\\\",\\n \\\"negative regulation of phosphorylation\\\",\\n \\\"regulation of kidney development\\\",\\n \\\"regulation of epidermis development\\\",\\n \\\"positive regulation of protein modification by small protein conjugation or removal\\\",\\n \\\"I-kappaB kinase/NF-kappaB signaling\\\",\\n \\\"regulation of transforming growth factor beta2 production\\\",\\n \\\"nodal signaling pathway\\\",\\n \\\"transforming growth factor beta receptor signaling pathway\\\",\\n \\\"gene silencing by miRNA\\\",\\n \\\"regulation of pathway-restricted SMAD protein phosphorylation\\\",\\n \\\"negative regulation of activin receptor signaling pathway\\\",\\n \\\"regulation of SMAD protein signal transduction\\\",\\n \\\"negative regulation of pathway-restricted SMAD protein phosphorylation\\\",\\n \\\"regulation of gene silencing by miRNA\\\",\\n \\\"negative regulation of cellular response to growth factor stimulus\\\",\\n \\\"regulation of epidermal cell differentiation\\\",\\n \\\"proteasomal protein catabolic process\\\",\\n \\\"regulation of production of small RNA involved in gene silencing by RNA\\\",\\n \\\"cellular response to transforming growth factor beta stimulus\\\",\\n \\\"positive regulation of protein catabolic process\\\",\\n \\\"regulation of protein modification by small protein conjugation or removal\\\",\\n \\\"positive regulation of MAPK cascade\\\",\\n \\\"regulation of DNA-templated transcription in response to stress\\\",\\n \\\"positive regulation of I-kappaB kinase/NF-kappaB signaling\\\",\\n \\\"negative regulation of fat cell differentiation\\\",\\n \\\"pathway-restricted SMAD protein phosphorylation\\\",\\n \\\"negative regulation of cell proliferation\\\",\\n \\\"regulation of transforming growth factor beta receptor signaling pathway\\\",\\n \\\"cellular response to BMP stimulus\\\",\\n \\\"regulation of cellular response to transforming growth factor beta stimulus\\\",\\n \\\"regulation of DNA binding transcription factor activity\\\",\\n \\\"regulation of BMP signaling pathway\\\",\\n \\\"negative regulation of intracellular signal transduction\\\",\\n \\\"regulation of posttranscriptional gene silencing\\\",\\n \\\"activation of MAPKK activity\\\",\\n \\\"negative regulation of transcription by competitive promoter binding\\\",\\n \\\"response to BMP\\\",\\n \\\"regulation of protein ubiquitination\\\",\\n \\\"histone modification\\\",\\n \\\"regulation of gene silencing by RNA\\\",\\n \\\"BMP signaling pathway\\\",\\n \\\"stress-activated MAPK cascade\\\",\\n \\\"positive regulation of SMAD protein signal transduction\\\",\\n \\\"response to transforming growth factor beta\\\",\\n \\\"regulation of vasculature development\\\",\\n \\\"positive regulation of epidermal cell differentiation\\\",\\n \\\"negative regulation of androgen receptor signaling pathway\\\",\\n \\\"SMAD protein signal transduction\\\",\\n \\\"negative regulation of myosin-light-chain-phosphatase activity\\\",\\n \\\"positive regulation of DNA binding transcription factor activity\\\",\\n \\\"regulation of angiogenesis\\\",\\n \\\"regulation of cellular response to growth factor stimulus\\\",\\n \\\"regulation of transmembrane receptor protein serine/threonine kinase signaling pathway\\\",\\n \\\"regulation of keratinocyte differentiation\\\",\\n \\\"activin receptor signaling pathway\\\",\\n \\\"regulation of epithelial cell differentiation\\\",\\n \\\"positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway\\\",\\n \\\"positive regulation of proteasomal ubiquitin-dependent protein catabolic process\\\",\\n \\\"regulation of stress-activated MAPK cascade\\\",\\n \\\"negative regulation of BMP signaling pathway\\\",\\n \\\"positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus\\\",\\n \\\"SMAD protein complex assembly\\\"\\n ],\\n \\\"predicted_disease\\\": [\\n \\\"aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709)\\\"\\n ]\\n },\\n \\\"interactions\\\": {\\n \\\"human_interactions\\\": {\\n \\\"Affinity Capture-Luminescence\\\": [\\n \\\"SMAD3\\\",\\n \\\"SMAD4\\\",\\n \\\"SMURF2\\\"\\n ],\\n \\\"Affinity Capture-MS\\\": [\\n \\\"ARID1A\\\",\\n \\\"ARID1B\\\",\\n \\\"ASH2L\\\",\\n \\\"ATAD3B\\\",\\n \\\"BCL7A\\\",\\n \\\"BTBD9\\\",\\n \\\"BUB3\\\",\\n \\\"C1ORF116\\\",\\n \\\"CAD\\\",\\n \\\"CCT6A\\\",\\n \\\"CDC27\\\",\\n \\\"CGA\\\",\\n \\\"CPSF7\\\",\\n \\\"CREBBP\\\",\\n \\\"CSNK1D\\\",\\n \\\"CTNNB1\\\",\\n \\\"CUL4A\\\",\\n \\\"CUL4B\\\",\\n \\\"DCAF7\\\",\\n \\\"DDX3Y\\\",\\n \\\"DGKA\\\",\\n \\\"DHX8\\\",\\n \\\"DNAJA2\\\",\\n \\\"DOCK9\\\",\\n \\\"DYRK1A\\\",\\n \\\"EPB41L5\\\",\\n \\\"ERBB2IP\\\",\\n \\\"EZH2\\\",\\n \\\"FAM83G\\\",\\n \\\"FLOT1\\\",\\n \\\"FLOT2\\\",\\n \\\"FYN\\\",\\n \\\"GSK3A\\\",\\n \\\"GTF3C2\\\",\\n \\\"GTF3C6\\\",\\n \\\"HCFC1\\\",\\n \\\"HDAC2\\\",\\n \\\"HDAC4\\\",\\n \\\"HINT3\\\",\\n \\\"HSPA4\\\",\\n \\\"ITGB4\\\",\\n \\\"KLF5\\\",\\n \\\"KMT2C\\\",\\n \\\"LDLRAD4\\\",\\n \\\"LEMD3\\\",\\n \\\"MED15\\\",\\n \\\"MED16\\\",\\n \\\"MED17\\\",\\n \\\"MED19\\\",\\n \\\"MED20\\\",\\n \\\"MED22\\\",\\n \\\"MED25\\\",\\n \\\"MED31\\\",\\n \\\"MED4\\\",\\n \\\"MED9\\\",\\n \\\"MEN1\\\",\\n \\\"MTMR4\\\",\\n \\\"NCOA3\\\",\\n \\\"OGT\\\",\\n \\\"OPA1\\\",\\n \\\"OTUB1\\\",\\n \\\"PARK2\\\",\\n \\\"PCBP1\\\",\\n \\\"PCID2\\\",\\n \\\"PLEKHA4\\\",\\n \\\"PSPC1\\\",\\n \\\"RIN1\\\",\\n \\\"SGSH\\\",\\n \\\"SIK3\\\",\\n \\\"SKI\\\",\\n \\\"SKIL\\\",\\n \\\"SLC25A3\\\",\\n \\\"SLC25A5\\\",\\n \\\"SLC25A6\\\",\\n \\\"SMAD1\\\",\\n \\\"SMAD3\\\",\\n \\\"SMAD4\\\",\\n \\\"SMAD5\\\",\\n \\\"SMAD9\\\",\\n \\\"SMARCA4\\\",\\n \\\"SMARCC1\\\",\\n \\\"SMARCC2\\\",\\n \\\"SMARCD2\\\",\\n \\\"SMPDL3B\\\",\\n \\\"SMURF2\\\",\\n \\\"SNW1\\\",\\n \\\"SNX27\\\",\\n \\\"SQRDL\\\",\\n \\\"TAF1\\\",\\n \\\"TAF2\\\",\\n \\\"TAF3\\\",\\n \\\"TAF5\\\",\\n \\\"TAF6\\\",\\n \\\"TMED8\\\",\\n \\\"TMOD1\\\",\\n \\\"TRIM28\\\",\\n \\\"TRIM33\\\",\\n \\\"TRIM67\\\",\\n \\\"U2AF2\\\",\\n \\\"WDR82\\\",\\n \\\"WRNIP1\\\",\\n \\\"WWP2\\\",\\n \\\"YAF2\\\",\\n \\\"YY1\\\",\\n \\\"ZFYVE9\\\"\\n ],\\n \\\"Affinity Capture-RNA\\\": [\\n \\\"DDX58\\\",\\n \\\"ELAVL1\\\"\\n ],\\n \\\"Affinity Capture-Western\\\": [\\n \\\"ACVR1B\\\",\\n \\\"ACVR2B\\\",\\n \\\"AKT1\\\",\\n \\\"ANAPC10\\\",\\n \\\"ATF3\\\",\\n \\\"BRCA2\\\",\\n \\\"CDC16\\\",\\n \\\"CDC27\\\",\\n \\\"CHUK\\\",\\n \\\"CITED2\\\",\\n \\\"CREBBP\\\",\\n \\\"CSNK1D\\\",\\n \\\"CTNNB1\\\",\\n \\\"DAB2\\\",\\n \\\"DOCK9\\\",\\n \\\"EID2\\\",\\n \\\"ELAC2\\\",\\n \\\"EP300\\\",\\n \\\"ERBB2IP\\\",\\n \\\"ESR1\\\",\\n \\\"ETV4\\\",\\n \\\"EZH2\\\",\\n \\\"FHL1\\\",\\n \\\"FHL2\\\",\\n \\\"FHL3\\\",\\n \\\"FOXH1\\\",\\n \\\"FOXP1\\\",\\n \\\"GLI1\\\",\\n \\\"GTF2I\\\",\\n \\\"GTF2IRD1\\\",\\n \\\"HDAC1\\\",\\n \\\"HGS\\\",\\n \\\"HYAL2\\\",\\n \\\"ING2\\\",\\n \\\"INSR\\\",\\n \\\"IRF3\\\",\\n \\\"IRF7\\\",\\n \\\"ITCH\\\",\\n \\\"JUN\\\",\\n \\\"KAT2A\\\",\\n \\\"KAT2B\\\",\\n \\\"KDM6B\\\",\\n \\\"KLF5\\\",\\n \\\"LEF1\\\",\\n \\\"MAPT\\\",\\n \\\"MED15\\\",\\n \\\"MED24\\\",\\n \\\"MED6\\\",\\n \\\"MEF2A\\\",\\n \\\"METTL14\\\",\\n \\\"METTL3\\\",\\n \\\"MYC\\\",\\n \\\"NEDD4\\\",\\n \\\"NEDD4L\\\",\\n \\\"NEDD9\\\",\\n \\\"NFYC\\\",\\n \\\"NOTCH4\\\",\\n \\\"NUP214\\\",\\n \\\"OTUB1\\\",\\n \\\"OVOL2\\\",\\n \\\"PIAS3\\\",\\n \\\"PIAS4\\\",\\n \\\"PIN1\\\",\\n \\\"PML\\\",\\n \\\"PRDM16\\\",\\n \\\"RBBP5\\\",\\n \\\"RELB\\\",\\n \\\"RGCC\\\",\\n \\\"RNF111\\\",\\n \\\"RUNX1\\\",\\n \\\"RUNX2\\\",\\n \\\"RUNX3\\\",\\n \\\"S100A4\\\",\\n \\\"SH2D2A\\\",\\n \\\"SKI\\\",\\n \\\"SKIL\\\",\\n \\\"SMAD2\\\",\\n \\\"SMAD3\\\",\\n \\\"SMAD4\\\",\\n \\\"SMAD6\\\",\\n \\\"SMAD7\\\",\\n \\\"SMARCA4\\\",\\n \\\"SMURF1\\\",\\n \\\"SMURF2\\\",\\n \\\"SOX9\\\",\\n \\\"SP1\\\",\\n \\\"SPTBN1\\\",\\n \\\"STRAP\\\",\\n \\\"TCF12\\\",\\n \\\"TGFBR1\\\",\\n \\\"TGFBR2\\\",\\n \\\"TGIF1\\\",\\n \\\"TP53\\\",\\n \\\"TRIM28\\\",\\n \\\"TRIM33\\\",\\n \\\"TSC2\\\",\\n \\\"UCHL1\\\",\\n \\\"USP15\\\",\\n \\\"USP2\\\",\\n \\\"USP7\\\",\\n \\\"USP9X\\\",\\n \\\"WWP1\\\",\\n \\\"WWP2\\\",\\n \\\"YAP1\\\",\\n \\\"ZEB1\\\",\\n \\\"ZFYVE9\\\"\\n ],\\n \\\"Biochemical Activity\\\": [\\n \\\"ACVR1B\\\",\\n \\\"CAMK2G\\\",\\n \\\"CDK2\\\",\\n \\\"CDK4\\\",\\n \\\"CDK8\\\",\\n \\\"CDK9\\\",\\n \\\"CSNK1D\\\",\\n \\\"ITCH\\\",\\n \\\"TGFBR1\\\"\\n ],\\n \\\"Co-crystal Structure\\\": [\\n \\\"SMAD4\\\"\\n ],\\n \\\"Co-fractionation\\\": [\\n \\\"AP1M1\\\",\\n \\\"ARID1B\\\",\\n \\\"CAV1\\\",\\n \\\"CREBBP\\\",\\n \\\"CTNNB1\\\",\\n \\\"HDAC1\\\",\\n \\\"HMGA2\\\",\\n \\\"MTA2\\\",\\n \\\"NAA15\\\",\\n \\\"NCOA3\\\",\\n \\\"PARP1\\\",\\n \\\"PML\\\",\\n \\\"PRKDC\\\",\\n \\\"RBM14\\\",\\n \\\"RELA\\\",\\n \\\"SMAD3\\\",\\n \\\"SMAD4\\\",\\n \\\"SMARCA4\\\",\\n \\\"SMARCC1\\\",\\n \\\"SMARCC2\\\",\\n \\\"SNF8\\\",\\n \\\"SUB1\\\",\\n \\\"TGFBR1\\\",\\n \\\"TRIM33\\\",\\n \\\"XRCC6\\\",\\n \\\"ZFYVE9\\\"\\n ],\\n \\\"Co-localization\\\": [\\n \\\"CAMK2A\\\",\\n \\\"TGFBR1\\\",\\n \\\"TP53\\\"\\n ],\\n \\\"FRET\\\": [\\n \\\"BECN1\\\",\\n \\\"LATS2\\\",\\n \\\"MYC\\\",\\n \\\"SMAD1\\\"\\n ],\\n \\\"Phenotypic Enhancement\\\": [\\n \\\"SMAD3\\\",\\n \\\"SNW1\\\"\\n ],\\n \\\"Phenotypic Suppression\\\": [\\n \\\"SMAD7\\\",\\n \\\"STRAP\\\"\\n ],\\n \\\"Positive Genetic\\\": [\\n \\\"SPPL3\\\"\\n ],\\n \\\"Proximity Label-MS\\\": [\\n \\\"CCNF\\\",\\n \\\"EPHA2\\\",\\n \\\"OPTN\\\",\\n \\\"RAB7A\\\",\\n \\\"SNCA\\\",\\n \\\"TGOLN2\\\"\\n ],\\n \\\"Reconstituted Complex\\\": [\\n \\\"ANAPC10\\\",\\n \\\"ANP32B\\\",\\n \\\"ANP32E\\\",\\n \\\"ATP5I\\\",\\n \\\"BPTF\\\",\\n \\\"CREBBP\\\",\\n \\\"DAB2\\\",\\n \\\"DVL1\\\",\\n \\\"ELAC2\\\",\\n \\\"ERBB2IP\\\",\\n \\\"ESR1\\\",\\n \\\"FHL1\\\",\\n \\\"FHL2\\\",\\n \\\"FHL3\\\",\\n \\\"FOXH1\\\",\\n \\\"HDAC2\\\",\\n \\\"HIPK2\\\",\\n \\\"HYAL2\\\",\\n \\\"INSR\\\",\\n \\\"IRF7\\\",\\n \\\"JUN\\\",\\n \\\"KAT2B\\\",\\n \\\"LCK\\\",\\n \\\"LEF1\\\",\\n \\\"MECOM\\\",\\n \\\"MEF2A\\\",\\n \\\"MEF2C\\\",\\n \\\"MYC\\\",\\n \\\"MYOCD\\\",\\n \\\"NEDD4L\\\",\\n \\\"NEFM\\\",\\n \\\"NFIA\\\",\\n \\\"NUP214\\\",\\n \\\"OTUB1\\\",\\n \\\"PARD3\\\",\\n \\\"PIAS3\\\",\\n \\\"PIK3CA\\\",\\n \\\"PIN1\\\",\\n \\\"PTMS\\\",\\n \\\"RHOA\\\",\\n \\\"SH2D2A\\\",\\n \\\"SKI\\\",\\n \\\"SMAD4\\\",\\n \\\"SMAD7\\\",\\n \\\"SMURF2\\\",\\n \\\"SNW1\\\",\\n \\\"SOD1\\\",\\n \\\"SP1\\\",\\n \\\"STUB1\\\",\\n \\\"SYT1\\\",\\n \\\"TP53\\\",\\n \\\"TUBA1B\\\",\\n \\\"UCHL5\\\",\\n \\\"YY1\\\",\\n \\\"ZFYVE9\\\"\\n ],\\n \\\"Two-hybrid\\\": [\\n \\\"ABTB1\\\",\\n \\\"AKT1\\\",\\n \\\"ANAPC2\\\",\\n \\\"ANK3\\\",\\n \\\"ANTXR2\\\",\\n \\\"BAZ1A\\\",\\n \\\"BTBD2\\\",\\n \\\"C22ORF46\\\",\\n \\\"C9ORF156\\\",\\n \\\"CISH\\\",\\n \\\"COPS5\\\",\\n \\\"CORO2A\\\",\\n \\\"CREBBP\\\",\\n \\\"CSH1\\\",\\n \\\"CSH2\\\",\\n \\\"CUL5\\\",\\n \\\"CYLC2\\\",\\n \\\"CYP11A1\\\",\\n \\\"DCUN1D1\\\",\\n \\\"DNAJB5\\\",\\n \\\"DNAJC7\\\",\\n \\\"DOCK8\\\",\\n \\\"DYNC1H1\\\",\\n \\\"DYRK1A\\\",\\n 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\\\"MIR6511A_5P\\\",\\n \\\"MIR12136\\\",\\n \\\"MIR3919\\\",\\n \\\"MIR3679_3P\\\",\\n \\\"MIR93_3P\\\",\\n \\\"MIR4272\\\",\\n \\\"MIR6731_5P\\\",\\n \\\"MIR208B_5P\\\",\\n \\\"MIR6792_5P\\\"\\n ],\\n \\\"C4\\\": [\\n \\\"GCM_UBE2N\\\",\\n \\\"MORF_PPP2R5E\\\",\\n \\\"MORF_BECN1\\\",\\n \\\"MORF_PRKAG1\\\",\\n \\\"MORF_RAB1A\\\",\\n \\\"MORF_UBE2A\\\",\\n \\\"MORF_TERF2IP\\\",\\n \\\"MORF_DDB1\\\",\\n \\\"MORF_SS18\\\",\\n \\\"MORF_TPR\\\",\\n \\\"GCM_MAX\\\",\\n \\\"GCM_DFFA\\\",\\n \\\"GCM_ZNF198\\\",\\n \\\"MORF_RAB11A\\\"\\n ],\\n \\\"C6\\\": [\\n \\\"SNF5_DN.V1_UP\\\"\\n ],\\n \\\"C7\\\": [\\n \\\"GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP\\\",\\n \\\"GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN\\\",\\n \\\"GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN\\\",\\n \\\"GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN\\\",\\n \\\"GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP\\\",\\n \\\"GSE36009_UNSTIM_VS_LPS_STIM_DC_DN\\\",\\n \\\"GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN\\\",\\n \\\"GSE339_CD4POS_VS_CD8POS_DC_DN\\\",\\n \\\"GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN\\\",\\n \\\"GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP\\\",\\n \\\"GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP\\\",\\n \\\"GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP\\\",\\n \\\"GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN\\\",\\n \\\"GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN\\\",\\n \\\"NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP\\\",\\n \\\"GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP\\\",\\n \\\"GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP\\\",\\n \\\"GSE27786_LIN_NEG_VS_CD4_TCELL_DN\\\",\\n \\\"GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN\\\",\\n \\\"GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN\\\",\\n \\\"GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN\\\",\\n \\\"GSE17721_LPS_VS_CPG_6H_BMDC_UP\\\",\\n \\\"NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP\\\",\\n \\\"GSE22886_IL2_VS_IL15_STIM_NKCELL_DN\\\",\\n \\\"GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN\\\",\\n \\\"GSE17721_12H_VS_24H_POLYIC_BMDC_UP\\\",\\n \\\"GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN\\\",\\n \\\"GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP\\\",\\n \\\"GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN\\\",\\n \\\"GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP\\\",\\n \\\"GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN\\\",\\n \\\"GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN\\\",\\n \\\"GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP\\\",\\n \\\"GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP\\\",\\n \\\"GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP\\\",\\n \\\"GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP\\\",\\n \\\"GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN\\\",\\n \\\"GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN\\\",\\n \\\"GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP\\\",\\n \\\"GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP\\\",\\n \\\"GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN\\\",\\n \\\"GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN\\\",\\n \\\"GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN\\\",\\n \\\"GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN\\\",\\n \\\"GSE17721_12H_VS_24H_CPG_BMDC_UP\\\",\\n \\\"GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN\\\",\\n \\\"GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN\\\",\\n \\\"GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP\\\",\\n \\\"GSE11818_WT_VS_DICER_KO_TREG_DN\\\",\\n \\\"GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP\\\",\\n \\\"GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP\\\",\\n \\\"GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP\\\",\\n \\\"GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP\\\",\\n \\\"GSE17721_POLYIC_VS_CPG_4H_BMDC_DN\\\",\\n \\\"GSE22886_TH1_VS_TH2_48H_ACT_DN\\\",\\n \\\"GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN\\\",\\n \\\"GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP\\\",\\n \\\"GSE27786_NKTCELL_VS_MONO_MAC_DN\\\",\\n \\\"GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN\\\",\\n \\\"GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN\\\",\\n \\\"GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN\\\",\\n \\\"GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP\\\",\\n \\\"GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN\\\",\\n \\\"GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP\\\",\\n \\\"GSE17721_LPS_VS_CPG_24H_BMDC_DN\\\",\\n \\\"GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP\\\"\\n ],\\n \\\"C8\\\": []\\n }\\n },\\n \\\"omim\\\": {\\n \\\"phenotype_annotations\\\": []\\n },\\n \\\"disgenet\\\": {\\n \\\"disease_annotations\\\": []\\n },\\n \\\"open_targets\\\": {\\n \\\"disease_annotations\\\": [\\n \\\"Overgrowth\\\",\\n \\\"Abnormality of the cardiovascular system\\\",\\n \\\"Mitral valve prolapse\\\",\\n \\\"Congestive heart failure\\\",\\n \\\"Patent ductus arteriosus\\\",\\n \\\"Dilated cardiomyopathy\\\",\\n \\\"Bicuspid aortic valve\\\",\\n \\\"Myocardial fibrosis\\\",\\n \\\"Increased total eosinophil count\\\",\\n \\\"Thrombocytosis\\\",\\n \\\"Anemia\\\",\\n \\\"Acute kidney injury\\\",\\n \\\"Glucose intolerance\\\",\\n \\\"Pulmonary hypoplasia\\\",\\n \\\"Pneumonia\\\",\\n \\\"Asthma\\\",\\n \\\"Ischemic stroke\\\",\\n \\\"Cerebral ischemia\\\",\\n \\\"Vascular dilatation\\\",\\n \\\"Aortic dissection\\\",\\n \\\"Systemic lupus erythematosus\\\",\\n \\\"Autoimmunity\\\",\\n \\\"Hyperglycemia\\\",\\n \\\"Hyperlipidemia\\\",\\n \\\"Hypercholesterolemia\\\",\\n \\\"Skeletal muscle atrophy\\\",\\n \\\"Muscular dystrophy\\\",\\n \\\"Cachexia\\\",\\n \\\"Thrombophlebitis\\\",\\n \\\"Miscarriage\\\",\\n \\\"Ureteral obstruction\\\",\\n \\\"Airway obstruction\\\",\\n \\\"Amyotrophic lateral sclerosis\\\",\\n \\\"Peripheral demyelination\\\",\\n \\\"Inflammatory abnormality of the skin\\\",\\n \\\"Arrhythmia\\\",\\n \\\"Myelofibrosis\\\",\\n \\\"Hepatitis\\\",\\n \\\"Reduced sperm motility\\\",\\n \\\"Urethral stricture\\\",\\n \\\"Renal atrophy\\\",\\n \\\"Cervical polyp\\\",\\n \\\"Shock\\\",\\n \\\"Granuloma\\\",\\n \\\"Chronic colitis\\\",\\n \\\"Neoplasm of the lung\\\",\\n \\\"Cognitive impairment\\\",\\n \\\"Sepsis\\\",\\n \\\"geleophysic dysplasia\\\",\\n \\\"colorectal adenoma\\\",\\n \\\"airway hyperresponsiveness\\\",\\n \\\"skin aging\\\",\\n \\\"triple-negative breast cancer\\\",\\n \\\"bile duct carcinoma\\\",\\n \\\"glioma\\\",\\n \\\"hydronephrosis\\\",\\n \\\"rectal adenocarcinoma\\\",\\n \\\"intracerebral hemorrhage\\\",\\n \\\"renal cell adenocarcinoma\\\",\\n \\\"Autoimmune Hepatitis\\\",\\n \\\"neurodegenerative disease\\\",\\n \\\"brain disease\\\",\\n \\\"aortic disease\\\",\\n \\\"allergic rhinitis\\\",\\n \\\"esophageal squamous cell carcinoma\\\",\\n \\\"head and neck neoplasia\\\",\\n \\\"breast ductal adenocarcinoma\\\",\\n \\\"laryngeal squamous cell carcinoma\\\",\\n \\\"ovarian adenocarcinoma\\\",\\n \\\"ovarian mucinous adenocarcinoma\\\",\\n \\\"ovarian teratoma\\\",\\n \\\"bladder transitional cell carcinoma\\\",\\n \\\"brain glioblastoma\\\",\\n \\\"dysplastic oral keratinocyte\\\",\\n \\\"undifferentiated carcinoma\\\",\\n \\\"cerebral amyloid angiopathy\\\",\\n \\\"head and neck malignant neoplasia\\\",\\n \\\"breastfeeding duration\\\",\\n \\\"urgency urinary incontinence\\\",\\n \\\"fibrosis\\\",\\n \\\"Balkan nephropathy\\\",\\n \\\"congenital rubella\\\",\\n \\\"echinococcosis\\\",\\n \\\"Gerstmann syndrome\\\",\\n \\\"inclusion body myositis\\\",\\n \\\"muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10\\\",\\n \\\"severe neurodegenerative syndrome with lipodystrophy\\\",\\n \\\"Diamond-Blackfan anemia\\\",\\n \\\"cardiofaciocutaneous syndrome\\\",\\n \\\"adrenomyeloneuropathy\\\",\\n \\\"hereditary sensory and autonomic neuropathy\\\",\\n \\\"nasopharyngeal carcinoma\\\",\\n \\\"keratoconus\\\",\\n \\\"dentin dysplasia\\\",\\n \\\"T-cell non-Hodgkin lymphoma\\\",\\n \\\"dyskeratosis congenita\\\",\\n \\\"pneumoconiosis\\\",\\n \\\"early myoclonic encephalopathy\\\",\\n \\\"laryngotracheoesophageal cleft\\\",\\n \\\"cleft palate\\\",\\n \\\"cryopyrin-associated periodic syndrome\\\",\\n \\\"holoprosencephaly\\\",\\n \\\"pachyonychia congenita\\\",\\n \\\"familial rhabdoid tumor\\\",\\n \\\"familial hyperaldosteronism\\\",\\n \\\"primary ciliary dyskinesia\\\",\\n \\\"meningioma\\\",\\n \\\"pilocytic astrocytoma\\\",\\n \\\"hemangioblastoma\\\",\\n \\\"microcephaly-brain defect-spasticity-hypernatremia syndrome\\\",\\n \\\"thanatophoric dysplasia\\\",\\n \\\"idiopathic pulmonary arterial hypertension\\\",\\n \\\"heritable pulmonary arterial hypertension\\\",\\n \\\"juvenile polyposis syndrome\\\",\\n \\\"congenital herpes simplex virus infection\\\",\\n \\\"popliteal pterygium syndrome\\\",\\n \\\"ameloblastoma\\\",\\n \\\"hypersensitivity pneumonitis\\\",\\n \\\"persistent truncus arteriosus\\\",\\n \\\"colorectal adenocarcinoma\\\",\\n \\\"Crohn's disease\\\",\\n \\\"cutaneous melanoma\\\",\\n \\\"diabetes mellitus\\\",\\n \\\"diabetic nephropathy\\\",\\n \\\"diffuse gastric adenocarcinoma\\\",\\n \\\"diffuse large B-cell lymphoma\\\",\\n \\\"breast ductal carcinoma in situ\\\",\\n \\\"emphysema\\\",\\n \\\"epilepsy\\\",\\n \\\"esophageal adenocarcinoma\\\",\\n \\\"fetal growth restriction\\\",\\n \\\"follicular thyroid adenoma\\\",\\n \\\"ganglioneuroma\\\",\\n \\\"follicular thyroid carcinoma\\\",\\n \\\"gastric adenocarcinoma\\\",\\n \\\"gastric intestinal type adenocarcinoma\\\",\\n \\\"genetic disorder\\\",\\n \\\"germ cell tumor\\\",\\n \\\"glioblastoma multiforme\\\",\\n \\\"hypertrophic cardiomyopathy\\\",\\n \\\"immune system disease\\\",\\n \\\"infection\\\",\\n \\\"infertility\\\",\\n \\\"injury\\\",\\n \\\"insulinoma\\\",\\n \\\"intracranial hemorrhage\\\",\\n \\\"ischemia\\\",\\n \\\"large cell neuroendocrine carcinoma\\\",\\n \\\"leukemia\\\",\\n \\\"lung adenocarcinoma\\\",\\n \\\"lymphoma\\\",\\n \\\"mesothelioma\\\",\\n \\\"metabolic disease\\\",\\n \\\"myocardial infarction\\\",\\n \\\"neoplasm\\\",\\n \\\"nervous system disease\\\",\\n \\\"neuroblastoma\\\",\\n \\\"oligodendroglioma\\\",\\n \\\"osteosarcoma\\\",\\n \\\"neural tube defect\\\",\\n \\\"tuberculosis\\\",\\n \\\"glioblastoma\\\",\\n \\\"carcinoma of liver and intrahepatic biliary tract\\\",\\n \\\"hereditary nonpolyposis colon cancer\\\",\\n \\\"Zika virus infectious disease\\\",\\n \\\"left ventricular noncompaction\\\",\\n \\\"multiminicore myopathy\\\",\\n \\\"Loeys-Dietz syndrome\\\",\\n \\\"neurofibromatosis type 1\\\",\\n \\\"Leber congenital amaurosis\\\",\\n \\\"osteogenesis imperfecta\\\",\\n \\\"progressive supranuclear palsy\\\",\\n \\\"intrahepatic cholestasis\\\",\\n \\\"lymphedema\\\",\\n \\\"posterior cortical atrophy\\\",\\n \\\"follicular lymphoma\\\",\\n \\\"kidney Wilms tumor\\\",\\n \\\"bronchopulmonary dysplasia\\\",\\n \\\"sarcoidosis\\\",\\n \\\"peeling skin syndrome\\\",\\n \\\"lissencephaly with cerebellar hypoplasia\\\",\\n \\\"aggressive NK-cell leukemia\\\",\\n \\\"adult T-cell leukemia/lymphoma\\\",\\n \\\"extranodal nasal NK/T cell lymphoma\\\",\\n \\\"Turner syndrome\\\",\\n \\\"familial thoracic aortic aneurysm and aortic dissection\\\",\\n \\\"Ehlers-Danlos syndrome\\\",\\n \\\"muscular dystrophy\\\",\\n \\\"precursor B-cell acute lymphoblastic leukemia\\\",\\n \\\"superficial spreading melanoma\\\",\\n \\\"lung neoplasm\\\",\\n \\\"intestinal neoplasm\\\",\\n \\\"odontogenic neoplasm\\\",\\n \\\"disorder of ear\\\",\\n \\\"endometrium neoplasm\\\",\\n \\\"prostate neoplasm\\\",\\n \\\"mucoepidermoid carcinoma of parotid gland\\\",\\n \\\"carcinoma of pharynx\\\",\\n \\\"polyp of colon\\\",\\n \\\"low grade glioma\\\",\\n \\\"corticobasal degeneration disorder\\\",\\n \\\"cervical intraepithelial neoplasia\\\",\\n \\\"viral myocarditis\\\",\\n \\\"lip and oral cavity carcinoma\\\",\\n \\\"corneal infection\\\",\\n \\\"pseudoxanthoma elasticum (inherited or acquired)\\\",\\n \\\"chondrogenic neoplasm\\\",\\n \\\"intraepithelial neoplasia\\\",\\n \\\"squamous cell intraepithelial neoplasia\\\",\\n \\\"liver and intrahepatic bile duct neoplasm\\\",\\n \\\"hypertensive nephropathy\\\",\\n \\\"myocardial disorder\\\",\\n \\\"tubular adenoma\\\",\\n \\\"pulmonary sarcoidosis\\\",\\n \\\"gonorrhea\\\",\\n \\\"B-cell acute lymphoblastic leukemia\\\",\\n \\\"chronic lymphocytic leukemia\\\",\\n \\\"gastric carcinoma\\\",\\n \\\"head and neck squamous cell carcinoma\\\",\\n \\\"hepatocellular carcinoma\\\",\\n \\\"Hodgkins lymphoma\\\",\\n \\\"invasive breast ductal carcinoma\\\",\\n \\\"metabolic syndrome\\\",\\n \\\"myelodysplastic syndrome\\\",\\n \\\"oral squamous cell carcinoma\\\",\\n \\\"gastritis\\\",\\n \\\"acute lymphoblastic leukemia\\\",\\n \\\"acute myeloid leukemia\\\",\\n \\\"acute promyelocytic leukemia\\\",\\n \\\"adenocarcinoma\\\",\\n \\\"adenoma\\\",\\n \\\"age\\\",\\n \\\"aortic stenosis\\\",\\n \\\"astrocytoma\\\",\\n \\\"atopic eczema\\\",\\n \\\"atrial fibrillation\\\",\\n \\\"Barrett's esophagus\\\",\\n \\\"benign prostatic hyperplasia\\\",\\n \\\"bladder tumor\\\",\\n \\\"breast adenocarcinoma\\\",\\n \\\"breast carcinoma\\\",\\n \\\"bronchoalveolar adenocarcinoma\\\",\\n \\\"carcinoma\\\",\\n \\\"cardiomyopathy\\\",\\n \\\"cardiovascular disease\\\",\\n \\\"central nervous system cancer\\\",\\n \\\"chondrosarcoma\\\",\\n \\\"chromophobe renal cell carcinoma\\\",\\n \\\"chronic myelogenous leukemia\\\",\\n \\\"chronic obstructive pulmonary disease\\\",\\n \\\"clear cell renal carcinoma\\\",\\n \\\"endometrial carcinoma\\\",\\n \\\"ovarian serous carcinoma\\\",\\n \\\"renal fibrosis\\\",\\n \\\"Abruptio Placentae\\\",\\n \\\"Adenomyosis\\\",\\n \\\"Carcinoma, Lewis Lung\\\",\\n \\\"chronic myelomonocytic leukemia\\\",\\n \\\"Marchiafava-Bignami Disease\\\",\\n \\\"oral submucous fibrosis\\\",\\n \\\"osteoradionecrosis\\\",\\n \\\"renal nutcracker syndrome\\\",\\n \\\"amyloidosis\\\",\\n \\\"mucositis\\\",\\n \\\"neuroendocrine neoplasm\\\",\\n \\\"neuromuscular disease\\\",\\n \\\"oral mucositis\\\",\\n \\\"Spinal cord injury\\\",\\n \\\"cutaneous squamous cell carcinoma\\\",\\n \\\"Barrett adenocarcinoma\\\",\\n \\\"colon adenocarcinoma\\\",\\n \\\"colon carcinoma\\\",\\n \\\"colorectal carcinoma\\\",\\n \\\"pharyngeal squamous cell carcinoma\\\",\\n \\\"soft tissue sarcoma\\\",\\n \\\"undifferentiated pleomorphic sarcoma\\\",\\n \\\"connective tissue disease\\\",\\n \\\"pneumonitis\\\",\\n \\\"intrahepatic cholangiocarcinoma\\\",\\n \\\"chronic rhinosinusitis with nasal polyps\\\",\\n \\\"chronic rhinosinusitis without nasal polyps\\\",\\n \\\"glomerular disease\\\",\\n \\\"nephritis\\\",\\n \\\"Neurogenic bladder\\\",\\n \\\"Glomerular sclerosis\\\",\\n \\\"Glomerulonephritis\\\",\\n \\\"Nephropathy\\\",\\n \\\"Uterine leiomyoma\\\",\\n \\\"Cleft palate\\\",\\n \\\"Hydrocephalus\\\",\\n \\\"Cataract\\\",\\n \\\"Myopia\\\",\\n \\\"Autism\\\",\\n \\\"Infertility\\\",\\n \\\"Diabetes mellitus\\\",\\n \\\"Insulin resistance\\\",\\n \\\"Osteoporosis\\\",\\n \\\"Hyperkeratosis\\\",\\n \\\"Intellectual disability\\\",\\n \\\"Ataxia\\\",\\n \\\"Mental deterioration\\\",\\n \\\"Stroke\\\",\\n \\\"Rheumatoid arthritis\\\",\\n \\\"Cirrhosis\\\",\\n \\\"Hepatic fibrosis\\\",\\n \\\"Hepatic steatosis\\\",\\n \\\"Obesity\\\",\\n \\\"mixed connective tissue disease\\\",\\n \\\"pneumocystosis\\\",\\n \\\"pseudomyxoma peritonei\\\",\\n \\\"silicosis\\\",\\n \\\"toxoplasmosis\\\",\\n \\\"hemoglobin A1 measurement\\\",\\n \\\"BMI-adjusted waist-hip ratio\\\",\\n \\\"liver dysplastic nodule\\\",\\n \\\"gut microbiome measurement\\\",\\n \\\"platelet crit\\\",\\n \\\"allergen exposure measurement\\\",\\n \\\"calf circumference measurement\\\",\\n \\\"dysplasia\\\",\\n \\\"lobular breast carcinoma\\\",\\n \\\"nodular melanoma\\\",\\n \\\"non-functioning pituitary adenoma\\\",\\n \\\"status epilepticus\\\",\\n \\\"steatosis\\\",\\n \\\"urothelial carcinoma\\\",\\n \\\"digestive system neoplasm\\\",\\n \\\"Hepatobiliary Neoplasm\\\",\\n \\\"American trypanosomiasis\\\",\\n \\\"acute myocardial infarction\\\",\\n \\\"pemphigus foliaceus\\\",\\n \\\"cystic kidney disease\\\",\\n \\\"Polycystic Kidney Disease\\\",\\n \\\"arteriosclerosis\\\",\\n \\\"hyperuricemia\\\",\\n \\\"skin carcinoma\\\",\\n \\\"heel bone mineral density\\\",\\n \\\"pulmonary fibrosis\\\",\\n \\\"hyperaldosteronism\\\",\\n \\\"gastric ulcer\\\",\\n \\\"infarction\\\",\\n \\\"aortic valve disease\\\",\\n \\\"heart valve disease\\\",\\n \\\"mitral valve disease\\\",\\n \\\"urinary tract obstruction\\\",\\n \\\"prostate disease\\\",\\n \\\"stomach disease\\\",\\n \\\"myocarditis\\\",\\n \\\"aneurysm\\\",\\n \\\"enthesopathy\\\",\\n \\\"musculoskeletal system disease\\\",\\n \\\"metastasis\\\",\\n \\\"Gallbladder Adenocarcinoma\\\",\\n \\\"Granular Cell Tumor\\\",\\n \\\"Hepatoblastoma\\\",\\n \\\"HER2 Positive Breast Carcinoma\\\",\\n \\\"Invasive Breast Carcinoma\\\",\\n \\\"Malignant Mesothelioma\\\",\\n \\\"Malignant Pancreatic Neoplasm\\\",\\n \\\"Medullomyoblastoma with Myogenic Differentiation\\\",\\n \\\"Microcystic Meningioma\\\",\\n \\\"Mixed Tumor of the Salivary Gland\\\",\\n \\\"Nasal Cavity Polyp\\\",\\n \\\"Osteoblastoma\\\",\\n \\\"Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation\\\",\\n \\\"Ovarian Endometriosis\\\",\\n \\\"Paraganglioma\\\",\\n \\\"Placental Choriocarcinoma\\\",\\n \\\"Rectal Tubular Adenoma\\\",\\n \\\"Sarcomatoid Carcinoma\\\",\\n \\\"Signet Ring Cell Gastric Adenocarcinoma\\\",\\n \\\"Synovial Chondromatosis\\\",\\n \\\"Testicular Non-Seminomatous Germ Cell Tumor\\\",\\n \\\"Testicular Yolk Sac Tumor\\\",\\n \\\"Thyroid Gland Undifferentiated (Anaplastic) Carcinoma\\\",\\n \\\"Uterine Carcinosarcoma\\\",\\n \\\"Vulvar Squamous Cell Carcinoma\\\",\\n \\\"acute respiratory distress syndrome\\\",\\n \\\"sarcopenia\\\",\\n \\\"rectum cancer\\\",\\n \\\"acanthosis nigricans\\\",\\n \\\"mucous membrane pemphigoid\\\",\\n \\\"punctate palmoplantar keratoderma type III\\\",\\n \\\"adrenal cortex carcinoma\\\",\\n \\\"alcoholic liver cirrhosis\\\",\\n \\\"atrophic gastritis\\\",\\n \\\"dental fluorosis\\\",\\n \\\"dry eye syndrome\\\",\\n \\\"Helicobacter pylori infectious disease\\\",\\n \\\"inflammatory breast carcinoma\\\",\\n \\\"multiple system atrophy\\\",\\n \\\"myeloid sarcoma\\\",\\n \\\"nodular goiter\\\",\\n \\\"periapical granuloma\\\",\\n \\\"pulmonary edema\\\",\\n \\\"renovascular hypertension\\\",\\n \\\"retinopathy of prematurity\\\",\\n \\\"rheumatic heart disease\\\",\\n \\\"thromboangiitis obliterans\\\",\\n \\\"tooth disease\\\",\\n \\\"uremia\\\",\\n \\\"non-alcoholic steatohepatitis\\\",\\n \\\"Cryptogenic Organizing Pneumonia\\\",\\n \\\"Fascioliasis\\\",\\n \\\"Follicular Cyst\\\",\\n \\\"Heavy Chain Disease\\\",\\n \\\"Hepatopulmonary Syndrome\\\",\\n \\\"Myocardial Ischemia\\\",\\n \\\"Pelvic Inflammatory Disease\\\",\\n \\\"Periapical Periodontitis\\\",\\n \\\"Peritoneal Fibrosis\\\",\\n \\\"Pneumonia, Aspiration\\\",\\n \\\"Respiratory Syncytial Virus Infection\\\",\\n \\\"diabetic cardiomyopathy\\\",\\n \\\"diabetic foot\\\",\\n \\\"endothelial dysfunction\\\",\\n \\\"Mantle cell lymphoma\\\",\\n \\\"Merkel cell skin cancer\\\",\\n \\\"schistosomiasis\\\",\\n \\\"abortion\\\",\\n \\\"Autosomal dominant polycystic kidney disease\\\",\\n \\\"osteoporosis-pseudoglioma syndrome\\\",\\n \\\"Bartsocas-Papas syndrome 1\\\",\\n \\\"congenital bilateral aplasia of vas deferens from CFTR mutation\\\",\\n \\\"SHOX-related short stature\\\",\\n \\\"intellectual disability, X-linked syndromic, Turner type\\\",\\n \\\"Fabry disease\\\",\\n \\\"X-linked corneal dermoid\\\",\\n \\\"Aarskog-Scott syndrome, X-linked\\\",\\n \\\"holoprosencephaly-hypokinesia-congenital contractures syndrome\\\",\\n \\\"Melnick-Needles syndrome\\\",\\n \\\"Duchenne muscular dystrophy\\\",\\n \\\"X-linked retinoschisis\\\",\\n \\\"Wilson disease\\\",\\n \\\"adenomyosis\\\",\\n \\\"Timothy syndrome\\\",\\n \\\"supranuclear palsy, progressive, 1\\\",\\n \\\"Ehlers-Danlos syndrome, musculocontractural type\\\",\\n \\\"tetrasomy 12p\\\",\\n \\\"sickle cell anemia\\\",\\n \\\"hypotonia-cystinuria syndrome\\\",\\n \\\"lymphangioleiomyomatosis\\\",\\n \\\"gastrointestinal stromal tumor\\\",\\n \\\"autoimmune lymphoproliferative syndrome type 2B\\\",\\n \\\"endometrial cancer\\\",\\n \\\"Loeys-Dietz syndrome 1\\\",\\n \\\"hyperinsulinemic hypoglycemia, familial, 4\\\",\\n \\\"preterm premature rupture of the membranes\\\",\\n \\\"Mungan syndrome\\\",\\n \\\"Crouzon syndrome-acanthosis nigricans syndrome\\\",\\n \\\"papillary renal cell carcinoma\\\",\\n \\\"papillary thyroid carcinoma\\\",\\n \\\"periodontitis\\\",\\n \\\"polycystic ovary syndrome\\\",\\n \\\"preeclampsia\\\",\\n \\\"prostate adenocarcinoma\\\",\\n \\\"psoriasis\\\",\\n \\\"pterygium\\\",\\n \\\"renal cell carcinoma\\\",\\n \\\"rheumatoid arthritis\\\",\\n \\\"sarcoma\\\",\\n \\\"severe acute respiratory syndrome\\\",\\n \\\"small cell lung carcinoma\\\",\\n \\\"squamous cell carcinoma\\\",\\n \\\"squamous cell lung carcinoma\\\",\\n \\\"spondyloarthropathy\\\",\\n \\\"stroke\\\",\\n \\\"subarachnoid hemorrhage\\\",\\n \\\"systemic scleroderma\\\",\\n \\\"ulcerative colitis\\\",\\n \\\"melanoma\\\",\\n \\\"hepatocellular adenoma\\\",\\n \\\"viral disease\\\",\\n \\\"HIV infection\\\",\\n \\\"idiopathic pulmonary fibrosis\\\",\\n \\\"malignant pleural mesothelioma\\\",\\n \\\"bacterial disease\\\",\\n \\\"pneumococcal infection\\\",\\n \\\"temporal lobe epilepsy\\\",\\n \\\"celiac disease\\\",\\n \\\"cervical carcinoma\\\",\\n \\\"cytomegalovirus infection\\\",\\n \\\"endometriosis\\\",\\n \\\"experimental autoimmune encephalomyelitis\\\",\\n \\\"parasitic infection\\\",\\n \\\"malaria\\\",\\n \\\"folate deficiency\\\",\\n \\\"lung carcinoma\\\",\\n \\\"ovarian carcinoma\\\",\\n \\\"familial amyotrophic lateral sclerosis\\\",\\n \\\"pulmonary arterial hypertension\\\",\\n \\\"age-related macular degeneration\\\",\\n \\\"synovial sarcoma\\\",\\n \\\"cerebral creatine deficiency syndrome\\\",\\n \\\"arterial disorder\\\",\\n \\\"glomerulosclerosis\\\",\\n \\\"villous adenoma\\\",\\n \\\"mucosal melanoma\\\",\\n \\\"ovarian clear cell cancer\\\",\\n \\\"central nervous system primitive neuroectodermal neoplasm\\\",\\n \\\"Crohn ileitis\\\",\\n \\\"vertebral column disorder\\\",\\n \\\"endometrial disorder\\\",\\n \\\"gastric cancer\\\",\\n \\\"penile cancer\\\",\\n \\\"myopia\\\",\\n \\\"pulmonary alveolar proteinosis\\\",\\n \\\"Chagas disease\\\",\\n \\\"leiomyoma\\\",\\n \\\"brain cancer\\\",\\n \\\"tuberous sclerosis\\\",\\n \\\"sick sinus syndrome\\\",\\n \\\"arteriovenous hemangioma/malformation\\\",\\n \\\"hypertensive heart disease\\\",\\n \\\"head and neck carcinoma\\\",\\n \\\"depressive disorder\\\",\\n \\\"pneumothorax\\\",\\n \\\"Richter syndrome\\\",\\n \\\"peritoneum cancer\\\",\\n \\\"thyroid cancer\\\",\\n \\\"disorder of sexual differentiation\\\",\\n \\\"vulvar melanoma\\\",\\n \\\"papilloma\\\",\\n \\\"rectosigmoid junction neoplasm\\\",\\n \\\"Treacher-Collins syndrome\\\",\\n \\\"prostatic acinar adenocarcinoma\\\",\\n \\\"gingival overgrowth\\\",\\n \\\"inherited lipid metabolism disorder\\\",\\n \\\"skin squamous cell carcinoma\\\",\\n \\\"teratoma\\\",\\n \\\"bone inflammation disease\\\",\\n \\\"extraosseous osteosarcoma\\\",\\n \\\"chondroblastic osteosarcoma\\\",\\n \\\"cerebral infarction\\\",\\n \\\"liver cancer\\\",\\n \\\"uterine cancer\\\",\\n \\\"lung benign neoplasm\\\",\\n \\\"skin cancer\\\",\\n \\\"cervical cancer\\\",\\n \\\"seminoma\\\",\\n \\\"breast angiosarcoma\\\",\\n \\\"cerebellar pilocytic astrocytoma\\\",\\n \\\"salivary gland adenoid cystic carcinoma\\\",\\n \\\"bile duct adenocarcinoma\\\",\\n \\\"gastroesophageal junction adenocarcinoma\\\",\\n \\\"thoracic cancer\\\",\\n \\\"acral lentiginous melanoma\\\",\\n \\\"endometrial mixed adenocarcinoma\\\",\\n \\\"female breast carcinoma\\\",\\n \\\"inflammation\\\",\\n \\\"erythrocyte volume\\\",\\n \\\"glomerular filtration rate\\\",\\n \\\"bone tissue density\\\",\\n \\\"progesterone amount\\\",\\n \\\"serum alanine aminotransferase amount\\\",\\n \\\"serum urea amount\\\",\\n \\\"serum creatinine amount\\\",\\n \\\"body height\\\",\\n \\\"cyst\\\",\\n \\\"Hypotonia - cystinuria syndrome\\\",\\n \\\"Chédiak-Higashi syndrome\\\",\\n \\\"Åland Islands eye disease\\\",\\n \\\"Hydrocephalus with stenosis of the aqueduct of Sylvius\\\",\\n \\\"Autoimmune lymphoproliferative syndrome with recurrent viral infections\\\",\\n \\\"Rare disease with thoracic aortic aneurysm and aortic dissection\\\",\\n \\\"Persistent Müllerian duct syndrome\\\",\\n \\\"WHIM syndrome\\\",\\n \\\"Familial adenomatous polyposis\\\",\\n \\\"Other metabolic disease\\\",\\n \\\"hematocrit\\\",\\n \\\"C-reactive protein measurement\\\",\\n \\\"hematological measurement\\\",\\n \\\"alkaline phosphatase measurement\\\",\\n \\\"cryptorchidism\\\",\\n \\\"lymphocyte count\\\",\\n \\\"gestational diabetes\\\",\\n \\\"acute lung injury\\\",\\n \\\"serum gamma-glutamyl transferase measurement\\\",\\n \\\"HbA1c measurement\\\",\\n \\\"high density lipoprotein cholesterol measurement\\\",\\n \\\"osteoarthritis, knee\\\",\\n \\\"wet macular degeneration\\\",\\n \\\"insomnia\\\",\\n \\\"hypothyroidism\\\",\\n \\\"pelvic organ prolapse\\\",\\n \\\"metabolite measurement\\\",\\n \\\"eosinophil count\\\",\\n \\\"lymph node metastatic carcinoma\\\",\\n \\\"embryonal carcinoma\\\",\\n \\\"lumbar disc degeneration\\\",\\n \\\"lean body mass\\\",\\n \\\"type 2 diabetes nephropathy\\\",\\n \\\"monocyte count\\\",\\n \\\"autoimmune disease\\\",\\n \\\"congenital heart disease\\\",\\n \\\"cholangiocarcinoma\\\",\\n \\\"human african trypanosomiasis\\\",\\n \\\"reading\\\",\\n \\\"congenital heart malformation\\\",\\n \\\"temporomandibular joint disorder\\\",\\n \\\"axial length measurement\\\",\\n \\\"myeloid leukemia\\\",\\n \\\"lupus erythematosus\\\",\\n \\\"allergic asthma\\\",\\n \\\"fatty liver disease\\\",\\n \\\"Alzheimer disease\\\",\\n \\\"asthma\\\",\\n \\\"urinary bladder carcinoma\\\",\\n \\\"cancer\\\",\\n \\\"glaucoma\\\",\\n \\\"schizophrenia\\\",\\n \\\"cataract\\\",\\n \\\"type 1 diabetes mellitus\\\",\\n \\\"type 2 diabetes mellitus\\\",\\n \\\"pulmonary hypertension\\\",\\n \\\"osteoarthritis\\\",\\n \\\"pancreatic ductal adenocarcinoma\\\",\\n \\\"bacterial urinary tract infection\\\",\\n \\\"multiple sclerosis\\\",\\n \\\"skin basal cell carcinoma\\\",\\n \\\"brain glioma\\\",\\n \\\"colorectal cancer\\\",\\n \\\"Wilms tumor\\\",\\n \\\"Townes-Brocks syndrome\\\",\\n \\\"nevoid basal cell carcinoma syndrome\\\",\\n \\\"breast cancer\\\",\\n \\\"congenital contractural arachnodactyly\\\",\\n \\\"Duane retraction syndrome\\\",\\n \\\"dyschromatosis symmetrica hereditaria\\\",\\n \\\"metastatic malignant neoplasm\\\",\\n \\\"Loeys-Dietz syndrome 6\\\",\\n \\\"cervical squamous intraepithelial neoplasia\\\",\\n \\\"leukoplakia\\\",\\n \\\"spinal cord injury\\\",\\n \\\"ulcer disease\\\",\\n \\\"desmoplastic melanoma\\\",\\n \\\"myelofibrosis\\\",\\n \\\"oral cavity carcinoma\\\",\\n \\\"rectal carcinoma\\\",\\n \\\"hydrocephalus, congenital, 3, with brain anomalies\\\",\\n \\\"nasal cavity and paranasal sinus carcinoma\\\",\\n \\\"COVID-19\\\",\\n \\\"Dravet syndrome\\\",\\n \\\"COVID-19–associated multisystem inflammatory syndrome in adults\\\",\\n \\\"disease arising from reactivation of latent virus\\\",\\n \\\"Friedreich ataxia\\\",\\n \\\"malignant glioma\\\",\\n \\\"achalasia-alacrima syndrome\\\",\\n \\\"metabolic bone disorder\\\",\\n \\\"congenital heart defects, multiple types, 8, with or without heterotaxy\\\",\\n \\\"postmenopausal osteoporosis\\\",\\n \\\"intestinal polyp\\\",\\n \\\"dissection\\\",\\n \\\"uterine neoplasm\\\",\\n \\\"pancreatic neoplasm\\\",\\n \\\"kidney neoplasm\\\",\\n \\\"breast neoplasm\\\",\\n \\\"brain aneurysm\\\",\\n \\\"colitis\\\",\\n \\\"osteoporosis\\\",\\n \\\"chronic kidney disease\\\",\\n \\\"ovarian neoplasm\\\",\\n \\\"acne\\\",\\n \\\"stomach neoplasm\\\",\\n \\\"ankylosing spondylitis\\\",\\n \\\"ciliopathy\\\",\\n \\\"deep vein thrombosis\\\",\\n \\\"obstructive sleep apnea\\\",\\n \\\"necrotizing enterocolitis\\\",\\n \\\"relapsing-remitting multiple sclerosis\\\",\\n \\\"angiosarcoma\\\",\\n \\\"colorectal neoplasm\\\",\\n \\\"atherosclerosis\\\",\\n \\\"open-angle glaucoma\\\",\\n \\\"androgenetic alopecia\\\",\\n \\\"basal cell carcinoma\\\",\\n \\\"IGA glomerulonephritis\\\",\\n \\\"hepatitis B virus infection\\\",\\n \\\"skin neoplasm\\\",\\n \\\"Keloid\\\",\\n \\\"Abdominal Aortic Aneurysm\\\",\\n \\\"chronic hepatitis C virus infection\\\",\\n \\\"eosinophilic esophagitis\\\",\\n \\\"focal segmental glomerulosclerosis\\\",\\n \\\"interstitial lung disease\\\",\\n \\\"mucocutaneous lymph node syndrome\\\",\\n \\\"myeloproliferative disorder\\\",\\n \\\"nephrotic syndrome\\\",\\n \\\"vascular disease\\\",\\n \\\"thoracic aortic aneurysm\\\",\\n \\\"venous thromboembolism\\\",\\n \\\"platelet count\\\",\\n \\\"body mass index\\\",\\n \\\"neuroimaging measurement\\\",\\n \\\"metastatic neoplasm\\\",\\n \\\"whole body water mass\\\",\\n \\\"kidney injury\\\",\\n \\\"bone metastasis\\\",\\n \\\"gastrointestinal disease\\\",\\n \\\"aspartate aminotransferase to alanine aminotransferase ratio\\\",\\n \\\"urea measurement\\\",\\n \\\"viral load\\\",\\n \\\"2-hydroxyacetaminophen sulfate measurement\\\",\\n \\\"aging\\\",\\n \\\"serum lipopolysaccharide activity\\\",\\n \\\"cecum adenocarcinoma\\\",\\n \\\"chronic rhinosinusitis\\\",\\n \\\"cystitis\\\",\\n \\\"ependymoma\\\",\\n \\\"granulosa cell tumor\\\",\\n \\\"metaplastic breast carcinoma\\\",\\n \\\"ovarian clear cell adenocarcinoma\\\",\\n \\\"pancreatic adenocarcinoma\\\",\\n \\\"pancreatic neuroendocrine tumor\\\",\\n \\\"ACTH-Producing Pituitary Gland Adenoma\\\",\\n \\\"Adenomatoid Odontogenic Tumor\\\",\\n \\\"Ampulla of Vater Carcinoma\\\",\\n \\\"Anal Squamous Cell Carcinoma\\\",\\n \\\"Anaplastic (Malignant) Meningioma\\\",\\n \\\"Appendix Adenocarcinoma\\\",\\n \\\"Appendix Goblet Cell Carcinoid\\\",\\n \\\"Atrophy\\\",\\n \\\"Atypical Meningioma\\\",\\n \\\"Bladder Small Cell Neuroendocrine Carcinoma\\\",\\n \\\"Breast Carcinoma by Gene Expression Profile\\\",\\n \\\"cervical squamous cell carcinoma\\\",\\n \\\"Columnar Cell Hyperplasia of the Breast\\\",\\n \\\"Duodenal Adenocarcinoma\\\",\\n \\\"Endometrial Clear Cell Adenocarcinoma\\\",\\n \\\"Endometrial Endometrioid Adenocarcinoma\\\",\\n \\\"Extramammary Paget Disease\\\",\\n \\\"fibrodysplasia ossificans progressiva\\\",\\n \\\"hereditary diffuse gastric adenocarcinoma\\\",\\n \\\"Holt-Oram syndrome\\\",\\n \\\"Huntington disease\\\",\\n \\\"Pallister-Hall syndrome\\\",\\n \\\"Nager acrofacial dysostosis\\\",\\n \\\"Marfan syndrome\\\",\\n \\\"Cowden syndrome 1\\\",\\n \\\"nail-patella syndrome\\\",\\n \\\"ovarian cancer\\\",\\n \\\"Andersen-Tawil syndrome\\\",\\n \\\"polyostotic fibrous dysplasia\\\",\\n \\\"juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome\\\",\\n \\\"nonpapillary renal cell carcinoma\\\",\\n \\\"Mobius syndrome\\\",\\n \\\"Peyronie disease\\\",\\n \\\"prostate cancer\\\",\\n \\\"retinoblastoma\\\",\\n \\\"acrodermatitis enteropathica\\\",\\n \\\"mitochondrial DNA depletion syndrome 4a\\\",\\n \\\"Alstrom syndrome\\\",\\n \\\"anencephaly 1\\\",\\n \\\"microphthalmia with limb anomalies\\\",\\n \\\"Bloom syndrome\\\",\\n \\\"lung cancer\\\",\\n \\\"cerebrotendinous xanthomatosis\\\",\\n \\\"cystic fibrosis\\\",\\n \\\"recessive dystrophic epidermolysis bullosa\\\",\\n \\\"Haim-Munk syndrome\\\",\\n \\\"Laurence-Moon syndrome\\\",\\n \\\"Nijmegen breakage syndrome\\\",\\n \\\"Miyoshi myopathy\\\",\\n \\\"Schwartz-Jampel syndrome\\\",\\n \\\"Leigh syndrome\\\",\\n \\\"multiple myeloma\\\",\\n \\\"cervical adenocarcinoma\\\",\\n \\\"liver disease\\\",\\n \\\"cirrhosis of liver\\\",\\n \\\"ischemic cardiomyopathy\\\",\\n \\\"lymphoid neoplasm\\\",\\n \\\"coronary artery disease\\\",\\n \\\"prostate carcinoma\\\",\\n \\\"aortic aneurysm\\\",\\n \\\"fibrosarcoma\\\",\\n \\\"hypertrophy\\\",\\n \\\"actinic keratosis\\\",\\n \\\"anaplastic astrocytoma\\\",\\n \\\"anaplastic oligodendroglioma\\\",\\n \\\"cardiac hypertrophy\\\",\\n \\\"AIDS dementia\\\",\\n \\\"pancreatic carcinoma\\\",\\n \\\"prostate intraepithelial neoplasia\\\",\\n \\\"thyroid carcinoma\\\",\\n \\\"insulin resistance\\\",\\n \\\"esophageal carcinoma\\\",\\n \\\"ovarian serous adenocarcinoma\\\",\\n \\\"rhabdomyosarcoma\\\",\\n \\\"medulloblastoma\\\",\\n \\\"acute megakaryoblastic leukaemia\\\",\\n \\\"hepatitis C virus infection\\\",\\n \\\"non-small cell lung carcinoma\\\",\\n \\\"pleomorphic liposarcoma\\\",\\n \\\"kidney disease\\\",\\n \\\"non-alcoholic fatty liver disease\\\",\\n \\\"Pick disease\\\",\\n \\\"testicular seminoma\\\",\\n \\\"osteomyelitis\\\",\\n \\\"spina bifida\\\",\\n \\\"heart failure\\\",\\n \\\"vitamin D deficiency\\\",\\n \\\"inflammatory bowel disease\\\",\\n \\\"diabetic retinopathy\\\",\\n \\\"heart disease\\\",\\n \\\"psoriatic arthritis\\\",\\n \\\"lung disease\\\",\\n \\\"dental caries\\\",\\n \\\"serous adenocarcinoma\\\",\\n \\\"retinopathy\\\",\\n \\\"adrenal gland neoplasm\\\"\\n ],\\n \\\"tissue_specific_expression\\\": {\\n \\\"frontal lobe\\\": -1,\\n \\\"endothelial cell of umbilical vein (resting)\\\": 2,\\n \\\"zone of skin\\\": 0,\\n \\\"regulatory T cell\\\": 1,\\n \\\"pancreas\\\": -1,\\n \\\"suprapubic skin\\\": -1,\\n \\\"temporal lobe\\\": -1,\\n \\\"parathyroid gland\\\": -1,\\n \\\"spleen\\\": -1,\\n \\\"Brodmann (1909) area 9\\\": -1,\\n \\\"breast\\\": -1,\\n \\\"Brodmann (1909) area 24\\\": -1,\\n \\\"alternatively activated macrophage\\\": 2,\\n \\\"segmented neutrophil of bone marrow\\\": 4,\\n \\\"placenta\\\": -1,\\n \\\"mature eosinophil\\\": 1,\\n \\\"granulocyte monocyte progenitor cell\\\": 0,\\n \\\"gall bladder\\\": -1,\\n \\\"esophagus muscularis mucosa\\\": -1,\\n \\\"seminal vesicle\\\": -1,\\n \\\"endocervix\\\": -1,\\n \\\"lower leg skin\\\": -1,\\n \\\"megakaryocyte-erythroid progenitor cell\\\": 0,\\n \\\"endothelial cell of umbilical vein (proliferating)\\\": 2,\\n \\\"CD8-positive, alpha-beta T cell\\\": 3,\\n \\\"cerebral cortex\\\": -1,\\n \\\"CD34-negative, CD41-positive, CD42-positive megakaryocyte cell\\\": 4,\\n \\\"hippocampus proper\\\": -1,\\n \\\"uterus\\\": -1,\\n \\\"CD4-positive, alpha-beta T cell\\\": 3,\\n \\\"tonsil\\\": -1,\\n \\\"esophagus\\\": 0,\\n \\\"transverse colon\\\": -1,\\n \\\"pituitary gland\\\": -1,\\n \\\"coronary artery\\\": -1,\\n \\\"memory B cell\\\": 0,\\n \\\"sigmoid colon\\\": -1,\\n \\\"cerebellum\\\": -1,\\n \\\"erythroblast\\\": 2,\\n \\\"prefrontal cortex\\\": -1,\\n \\\"nucleus accumbens\\\": -1,\\n \\\"adipose tissue\\\": 0,\\n \\\"effector memory CD8-positive, alpha-beta T cell\\\": 1,\\n \\\"vermiform appendix\\\": -1,\\n \\\"greater omentum\\\": -1,\\n \\\"hematopoietic multipotent progenitor cell\\\": 1,\\n \\\"leukocyte\\\": 2,\\n \\\"adrenal gland\\\": -1,\\n \\\"atrium auricular region\\\": -1,\\n \\\"thyroid gland\\\": 0,\\n \\\"tibial artery\\\": -1,\\n \\\"common lymphoid progenitor\\\": 3,\\n \\\"urinary bladder\\\": -1,\\n \\\"duodenum\\\": -1,\\n \\\"heart muscle\\\": -1,\\n \\\"small intestine\\\": -1,\\n \\\"neutrophilic metamyelocyte\\\": 3,\\n \\\"minor salivary gland\\\": -1,\\n \\\"rectum\\\": 0,\\n \\\"ovary\\\": -1,\\n \\\"substantia nigra\\\": -1,\\n \\\"subcutaneous adipose tissue\\\": -1,\\n \\\"class switched memory B cell\\\": 1,\\n \\\"fallopian tube\\\": -1,\\n \\\"esophagus mucosa\\\": -1,\\n \\\"CD38-negative naive B cell\\\": 0,\\n \\\"bronchus\\\": -1,\\n \\\"EBV-transformed lymphocyte\\\": 0,\\n \\\"small intestine Peyer's patch\\\": -1,\\n \\\"kidney\\\": -1,\\n \\\"hippocampus\\\": -1,\\n \\\"macrophage\\\": 1,\\n \\\"aorta\\\": -1,\\n \\\"skeletal muscle tissue\\\": -1,\\n \\\"CD3-positive, CD4-positive, CD8-positive, double positive thymocyte\\\": 4,\\n \\\"caudate-putamen\\\": -1,\\n \\\"liver\\\": -1,\\n \\\"cytotoxic CD56-dim natural killer cell\\\": 2,\\n \\\"mature neutrophil\\\": 2,\\n \\\"hypothalamus\\\": -1,\\n \\\"transformed skin fibroblast\\\": -1,\\n \\\"bone marrow\\\": -1,\\n \\\"inflammatory macrophage\\\": 0,\\n \\\"cortex of kidney\\\": -1,\\n \\\"lung\\\": -1,\\n \\\"epididymis\\\": -1,\\n \\\"abdomen\\\": -1,\\n \\\"saliva-secreting gland\\\": -1,\\n \\\"nasopharynx\\\": -1,\\n \\\"colon\\\": 0,\\n \\\"cerebellar hemisphere\\\": -1,\\n \\\"stomach\\\": -1,\\n \\\"testis\\\": -1,\\n \\\"smooth muscle tissue\\\": 0,\\n \\\"putamen\\\": -1,\\n \\\"CD4-positive, alpha-beta thymocyte\\\": 5,\\n \\\"C1 segment of cervical spinal cord\\\": 0,\\n \\\"blood\\\": -1,\\n \\\"hematopoietic stem cell\\\": 1,\\n \\\"caudate nucleus\\\": -1,\\n \\\"amygdala\\\": -1,\\n \\\"brain\\\": 0,\\n \\\"central memory CD8-positive, alpha-beta T cell\\\": 1,\\n \\\"effector memory CD4-positive, alpha-beta T cell\\\": 1,\\n \\\"ectocervix\\\": -1,\\n \\\"prostate gland\\\": -1,\\n \\\"conventional dendritic cell\\\": 4,\\n \\\"central memory CD4-positive, alpha-beta T cell\\\": 1,\\n \\\"heart left ventricle\\\": -1,\\n \\\"CD14-positive, CD16-negative classical monocyte\\\": 0,\\n \\\"vagina\\\": -1,\\n \\\"esophagogastric junction\\\": -1,\\n \\\"lymph node\\\": -1,\\n \\\"endometrium\\\": -1,\\n \\\"heart\\\": -1,\\n \\\"oral mucosa\\\": -1,\\n \\\"CD8-positive, alpha-beta thymocyte\\\": 4,\\n \\\"common myeloid progenitor\\\": 0,\\n \\\"tibial nerve\\\": -1,\\n \\\"plasma cell\\\": -1\\n },\\n \\\"is_essential\\\": false,\\n \\\"genetic_constraint\\\": {\\n \\\"syn\\\": 0.11195000261068344,\\n \\\"mis\\\": 4.47730016708374,\\n \\\"lof\\\": 1.0\\n },\\n \\\"pharmacovigilance\\\": []\\n },\\n \\\"transcriptome\\\": {\\n \\\"transcripts\\\": {},\\n \\\"isoforms\\\": {\\n \\\"general_localization\\\": {\\n \\\"name\\\": \\\"general_localization\\\",\\n \\\"aliases\\\": [],\\n \\\"status\\\": null,\\n \\\"locations\\\": [\\n \\\"Cytoplasm\\\",\\n \\\"Nucleus\\\"\\n ],\\n \\\"notes\\\": [\\n \\\"Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity)\\\",\\n \\\"TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta\\\"\\n ]\\n }\\n },\\n \\\"avg_exons_per_transcript\\\": null,\\n \\\"transcript_count\\\": 0,\\n \\\"total_exon_count\\\": null,\\n \\\"median_transcript_span_bp\\\": null,\\n \\\"max_transcript_span_bp\\\": null\\n },\\n \\\"gwas_profile\\\": null,\\n \\\"variants\\\": {},\\n \\\"traits\\\": [],\\n \\\"binding_peaks\\\": {},\\n \\\"mirna_targets\\\": {},\\n \\\"alliancegenome_info\\\": [],\\n \\\"viral_interactions\\\": [],\\n \\\"text_summaries_from_tools\\\": [\\n \\\"*Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74\\\",\\n \\\"*ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\\",\\n \\\"*MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\\",\\n \\\"*UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.\\\",\\n \\\"*OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\\\\\"small intestine Peyer's patch\\\\\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0\\\",\\n \\\"*HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709).\\\",\\n \\\"*GO: SMAD2 representative GO terms: C:cytoplasm, C:nucleus, C:chromatin, C:heteromeric SMAD protein complex, C:cytosol, C:nucleoplasm, F:DNA-binding transcription factor activity, F:disordered domain specific binding, F:identical protein binding, F:transforming growth factor beta receptor binding, F:cis-regulatory region sequence-specific DNA binding, F:metal ion binding, P:primary miRNA processing, P:lung development, P:endoderm formation, P:odontoblast differentiation, P:determination of left/right asymmetry in lateral mesoderm, P:gastrulation.\\\"\\n ],\\n \\\"tools_run\\\": [\\n \\\"EntityExtraction\\\",\\n \\\"MSigDB\\\",\\n \\\"uniprot_entry\\\",\\n \\\"BioGRID\\\",\\n \\\"OpenTargets\\\",\\n \\\"reactome_pathways\\\",\\n \\\"humanbase_predictions\\\"\\n ]\\n}\"],[\"20251224-191245_ui/genes/SMAD2/summary.txt\",\"• Symbol: SMAD2 | Entrez: 4087 | UniProt: Q15796\\n• Transcripts: n_transcripts=0:\\n• Pathways: SMAD2/3 Phosphorylation Motif Mutants in Cancer; Developmental Biology; Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer; Deubiquitination; TGF-beta receptor signaling activates SMADs; Signaling by TGFB family members; Loss of Function of TGFBR1 in Cancer; Signaling by TGF-beta Receptor Complex; TGFBR1 KD Mutants in Cancer; Post-translational protein modification; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Disease; Generic Transcription Pathway; Metabolism of proteins; Gene expression (Transcription); Signal Transduction; FOXO-mediated transcription; Gastrulation; RNA Polymerase II Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of cell cycle genes; Loss of Function of SMAD2/3 in Cancer; Transcriptional regulation of pluripotent stem cells; SMAD4 MH2 Domain Mutants in Cancer; Diseases of signal transduction by growth factor receptors and second messengers; Formation of axial mesoderm; Germ layer formation at gastrulation; Downregulation of TGF-beta receptor signaling; Formation of definitive endoderm; Ub-specific processing proteases; Loss of Function of SMAD4 in Cancer; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SMAD2/3 MH2 Domain Mutants in Cancer; Signaling by Activin; Signaling by TGF-beta Receptor Complex in Cancer; Signaling by NODAL\\n• GO: C:SMAD protein complex; C:activin responsive factor complex; C:chromatin; C:cytoplasm; C:cytosol; C:heteromeric SMAD protein complex; C:homomeric SMAD protein complex; C:intracellular membrane-bounded organelle; C:nucleoplasm; C:nucleus; C:protein-containing complex; C:transcription regulator complex; F:DNA-binding transcription activator activity, RNA polymerase II-specific; F:DNA-binding transcription factor activity; F:DNA-binding transcription factor activity, RNA polymerase II-specific; F:DNA-binding transcription factor binding; F:I-SMAD binding; F:R-SMAD binding; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; F:RNA polymerase II-specific DNA-binding transcription factor binding; F:SMAD binding; F:chromatin binding; F:cis-regulatory region sequence-specific DNA binding; F:co-SMAD binding; F:disordered domain specific binding; F:double-stranded DNA binding; F:identical protein binding; F:metal ion binding; F:phosphatase binding; F:tau protein binding; F:transforming growth factor beta receptor binding; F:type I transforming growth factor beta receptor binding; F:ubiquitin protein ligase binding; P:DNA-templated transcription; P:SMAD protein signal transduction; P:activin receptor signaling pathway; P:anatomical structure morphogenesis; P:anterior/posterior pattern specification; P:aortic valve morphogenesis; P:cell differentiation; P:cell fate commitment; P:cell population proliferation; P:determination of left/right asymmetry in lateral mesoderm; P:embryonic cranial skeleton morphogenesis; P:embryonic foregut morphogenesis; P:endocardial cushion morphogenesis; P:endoderm formation; P:gastrulation; P:in utero embryonic development; P:insulin secretion; P:intracellular signal transduction; P:lung development; P:mesoderm formation; P:negative regulation of DNA-templated transcription; P:negative regulation of cell differentiation; P:negative regulation of ossification; P:nodal signaling pathway; P:odontoblast differentiation; P:organ growth; P:pancreas development; P:paraxial mesoderm morphogenesis; P:pericardium development; P:positive regulation of BMP signaling pathway; P:positive regulation of DNA-templated transcription; P:positive regulation of epithelial to mesenchymal transition; P:positive regulation of gene expression; P:positive regulation of transcription by RNA polymerase II; P:post-embryonic development; P:primary miRNA processing; P:pulmonary valve morphogenesis; P:regulation of DNA-templated transcription; P:regulation of transforming growth factor beta receptor signaling pathway; P:response to cholesterol; P:response to glucose; P:secondary palate development; P:transforming growth factor beta receptor signaling pathway; P:trophoblast cell migration; P:ureteric bud development; P:zygotic specification of dorsal/ventral axis\\n• Interactions from human data (Affinity Capture-Luminescence): SMAD3, SMAD4, SMURF2\\n• Interactions from human data (Affinity Capture-MS): ARID1A, ARID1B, ASH2L, ATAD3B, BCL7A, BTBD9, BUB3, C1ORF116, CAD, CCT6A, CDC27, CGA, CPSF7, CREBBP, CSNK1D, CTNNB1, CUL4A, CUL4B, DCAF7, DDX3Y, DGKA, DHX8, DNAJA2, DOCK9, DYRK1A, EPB41L5, ERBB2IP, EZH2, FAM83G, FLOT1, FLOT2, FYN, GSK3A, GTF3C2, GTF3C6, HCFC1, HDAC2, HDAC4, HINT3, HSPA4, ITGB4, KLF5, KMT2C, LDLRAD4, LEMD3, MED15, MED16, MED17, MED19, MED20, MED22, MED25, MED31, MED4, MED9, MEN1, MTMR4, NCOA3, OGT, OPA1, OTUB1, PARK2, PCBP1, PCID2, PLEKHA4, PSPC1, RIN1, SGSH, SIK3, SKI, SKIL, SLC25A3, SLC25A5, SLC25A6, SMAD1, SMAD3, SMAD4, SMAD5, SMAD9, SMARCA4, SMARCC1, SMARCC2, SMARCD2, SMPDL3B, SMURF2, SNW1, SNX27, SQRDL, TAF1, TAF2, TAF3, TAF5, TAF6, TMED8, TMOD1, TRIM28, TRIM33, TRIM67, U2AF2, WDR82, WRNIP1, WWP2, YAF2, YY1, ZFYVE9\\n• Interactions from human data (Affinity Capture-RNA): DDX58, ELAVL1\\n• Interactions from human data (Affinity Capture-Western): ACVR1B, ACVR2B, AKT1, ANAPC10, ATF3, BRCA2, CDC16, CDC27, CHUK, CITED2, CREBBP, CSNK1D, CTNNB1, DAB2, DOCK9, EID2, ELAC2, EP300, ERBB2IP, ESR1, ETV4, EZH2, FHL1, FHL2, FHL3, FOXH1, FOXP1, GLI1, GTF2I, GTF2IRD1, HDAC1, HGS, HYAL2, ING2, INSR, IRF3, IRF7, ITCH, JUN, KAT2A, KAT2B, KDM6B, KLF5, LEF1, MAPT, MED15, MED24, MED6, MEF2A, METTL14, METTL3, MYC, NEDD4, NEDD4L, NEDD9, NFYC, NOTCH4, NUP214, OTUB1, OVOL2, PIAS3, PIAS4, PIN1, PML, PRDM16, RBBP5, RELB, RGCC, RNF111, RUNX1, RUNX2, RUNX3, S100A4, SH2D2A, SKI, SKIL, SMAD2, SMAD3, SMAD4, SMAD6, SMAD7, SMARCA4, SMURF1, SMURF2, SOX9, SP1, SPTBN1, STRAP, TCF12, TGFBR1, TGFBR2, TGIF1, TP53, TRIM28, TRIM33, TSC2, UCHL1, USP15, USP2, USP7, USP9X, WWP1, WWP2, YAP1, ZEB1, ZFYVE9\\n• Interactions from human data (Biochemical Activity): ACVR1B, CAMK2G, CDK2, CDK4, CDK8, CDK9, CSNK1D, ITCH, TGFBR1\\n• Interactions from human data (Co-crystal Structure): SMAD4\\n• Interactions from human data (Co-fractionation): AP1M1, ARID1B, CAV1, CREBBP, CTNNB1, HDAC1, HMGA2, MTA2, NAA15, NCOA3, PARP1, PML, PRKDC, RBM14, RELA, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, SNF8, SUB1, TGFBR1, TRIM33, XRCC6, ZFYVE9\\n• Interactions from human data (Co-localization): CAMK2A, TGFBR1, TP53\\n• Interactions from human data (FRET): BECN1, LATS2, MYC, SMAD1\\n• Interactions from human data (Phenotypic Enhancement): SMAD3, SNW1\\n• Interactions from human data (Phenotypic Suppression): SMAD7, STRAP\\n• Interactions from human data (Positive Genetic): SPPL3\\n• Interactions from human data (Proximity Label-MS): CCNF, EPHA2, OPTN, RAB7A, SNCA, TGOLN2\\n• Interactions from human data (Reconstituted Complex): ANAPC10, ANP32B, ANP32E, ATP5I, BPTF, CREBBP, DAB2, DVL1, ELAC2, ERBB2IP, ESR1, FHL1, FHL2, FHL3, FOXH1, HDAC2, HIPK2, HYAL2, INSR, IRF7, JUN, KAT2B, LCK, LEF1, MECOM, MEF2A, MEF2C, MYC, MYOCD, NEDD4L, NEFM, NFIA, NUP214, OTUB1, PARD3, PIAS3, PIK3CA, PIN1, PTMS, RHOA, SH2D2A, SKI, SMAD4, SMAD7, SMURF2, SNW1, SOD1, SP1, STUB1, SYT1, TP53, TUBA1B, UCHL5, YY1, ZFYVE9\\n• Interactions from human data (Two-hybrid): ABTB1, AKT1, ANAPC2, ANK3, ANTXR2, BAZ1A, BTBD2, C22ORF46, C9ORF156, CISH, COPS5, CORO2A, CREBBP, CSH1, CSH2, CUL5, CYLC2, CYP11A1, DCUN1D1, DNAJB5, DNAJC7, DOCK8, DYNC1H1, DYRK1A, EEF1A1, EIF3L, EP300, ETV4, FAM161B, FBP2, FOXH1, GATAD2B, GFER, HSD17B3, INSR, KHDRBS1, KIAA1033, KPNB1, LAMA5, LEMD3, MAP2K1, MLLT4, MYC, NAGK, NCOA6, NEDD4L, OS9, PAPOLA, PAPPA, PAXIP1, PEX19, PIAS4, PLIN3, POU2AF1, PPP2R1A, PRKAR1A, PSAP, PSG9, PSMD11, PSMD8, RANBP6, RANBP9, RARB, RASA1, RNF123, RNPC3, ROCK1, RPS14, RPS27A, RXRA, SKI, SKIL, SMAD1, SMAD2, SMAD3, SMAD4, SMAD9, SMURF1, SMURF2, SNAPIN, SNIP1, SNRNP70, SNW1, SP1, SRI, ST13, ST5, TBC1D1, TGIF1, TGM2, TRIM62, UBA52, UBR5, XPA, ZEB2, ZFYVE9, ZMYND11, ZNF41, ZNF510, ZNHIT6\\n• Interactions from additional (non-human) data: (Affinity Capture-Luminescence): ARHGEF1, ARHGEF6, ARHGEF7, ARL4D, CDC40, FBXO3, IRAK2, LHX9, LMO2, MAP2K3, NUAK2, PPP2R2D, RAB34, RAB38, RASD2, RGS3, RHEBL1, RHOBTB1, RHOD, RHOJ, RPS27A, SMAD2, SMAD3, SQSTM1, TRIM35, UHMK1, WWP2\\n• Interactions from additional (non-human) data: (Affinity Capture-MS): ALDH4A1, BACH1, E6, FANCD2, NSP16AB, OTUB1, PAXIP1, RUNX1\\n• Interactions from additional (non-human) data: (Affinity Capture-Western): COL1A1, COL3A1, COL5A1, DOK1, E6, E7, GATA4, HCVGP1, KAP-ALPHA3, KLF4, LEF1, MED, MED15, MEF2A, RNF111, SKI, SMAD2, SMAD4, SMOX, SNOO, UBX, VIS, WWTR1, YAP1\\n• Interactions from additional (non-human) data: (Co-localization): E7, EZH2-A, KLF4\\n• Interactions from additional (non-human) data: (PCA): E6, SMOX\\n• Interactions from additional (non-human) data: (Phenotypic Enhancement): BABO, INR, SMOX, YKI\\n• Interactions from additional (non-human) data: (Phenotypic Suppression): BABO, HPO, INR, MYO, PLUM, PTEN, SCGDELTA, SMOX\\n• Interactions from additional (non-human) data: (Reconstituted Complex): E7, LEMD3, SMAD2, SOX9, UBX, ZFP128\\n• Interactions from additional (non-human) data: (Two-hybrid): CG18095, D, E6, EG, FOXH1, HOXA13, HOXD13, HR78, SMAD2, SMOX, UBX, ZEB2, ZEN\\n• *Protein: Gene: SMAD2 UniProt ID: Q15796 Protein ID: Q15796_F1 pLDDT: min=24.84 max=98.76 avg=77.33573875803002 FPocket: min=0.0 max=0.713 avg=0.03704122055674514 SASA: min=0.0 max=252.974 avg=71.54862955032118 total_area=33413.20999999999 Polarity Index: min=-1.0 max=1.0 avg=-0.26971827527401165 Disorder consensus: min=0.01935 max=0.8895 pct_disordered=22.698072805139187 num_regions=3 longest_region=68 avg_short=0.2857047109207708 avg_long=0.31360449678800856 n_disprot_regions=3 threshold=0.5 min_segment_len=5.0 MoRF propensity: min=0.0164 max=0.8437 pct_high=14.132762312633833 num_segments=1 longest_segment=66 threshold=0.5 min_segment_len=5.0 CysDB cysteine chemoproteomics summary: UniProt: Q15796 CysDB Cysteines Entries: detected=14, hyperreactive=0, ligandable=2, is_act_site=0, near_act_site=0, is_bind_site=3, near_bind_site=2 Ligandable: Q15796_C74 Q15796_C81 Near binding-site cysteines: Q15796_C70 C74 Q15796_C81 C74\\n• *ChEMBL: Gene: SMAD2 UniProt ID: Q15796 No ChEMBL druggability data found.\\n• *MSigDB: Collection H (Hallmark gene sets - Summarize and represent specific well-defined biological states or processes and display coherent expression. These gene sets were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.) for SMAD2: HALLMARK_PI3K_AKT_MTOR_SIGNALING. *MSigDB: Collection C1 (Positional gene sets - Gene sets corresponding to human chromosome cytogenetic bands.) for SMAD2: chr18q21. *MSigDB: Collection C2 (Curated gene sets - Gene sets in this collection are curated from various sources, including online pathway databases and the biomedical literature. Many sets are also contributed by individual domain experts.) for SMAD2: SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, KEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY, WP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING, REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING, RAMALHO_STEMNESS_UP, WP_PANCREATIC_ADENOCARCINOMA_PATHWAY, WP_TH17_CELL_DIFFERENTIATION_PATHWAY, GU_PDEF_TARGETS_UP, REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION, KEGG_ADHERENS_JUNCTION, KEGG_WNT_SIGNALING_PATHWAY, REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS, WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING, WP_PROGERIAASSOCIATED_LIPODYSTROPHY, WP_IL26_SIGNALING, REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER, WP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA, REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES, WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING, BENPORATH_PROLIFERATION, WP_ENDODERM_DIFFERENTIATION, WP_TGFBETA_RECEPTOR_SIGNALING, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3, WP_HEPATITIS_B_INFECTION, WP_CANCER_PATHWAYS, WP_LDLRAD4_AND_WHAT_WE_KNOW_ABOUT_IT, WP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP, REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION, REACTOME_SIGNALING_BY_NODAL, PID_SMAD2_3NUCLEAR_PATHWAY, REACTOME_FORMATION_OF_AXIAL_MESODERM, WP_CELL_CYCLE, WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES, OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP, WP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER, REACTOME_FORMATION_OF_DEFINITIVE_ENDODERM, REACTOME_DEUBIQUITINATION, WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS, TURJANSKI_MAPK1_AND_MAPK2_TARGETS, REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES, REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES, WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER, HOSHIDA_LIVER_CANCER_SUBCLASS_S1, WP_HIPPO_SIGNALING_REGULATION, PID_MYC_REPRESS_PATHWAY, WP_INTEGRATED_BREAST_CANCER_PATHWAY, BLALOCK_ALZHEIMERS_DISEASE_UP, POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_UP, KEGG_CELL_CYCLE, WP_1P36_COPY_NUMBER_VARIATION_SYNDROME, YOSHIMURA_MAPK8_TARGETS_DN, WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY, WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS, WP_AGERAGE_PATHWAY, KEGG_PANCREATIC_CANCER, REACTOME_GASTRULATION, REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION, WP_INTEGRATED_CANCER_PATHWAY, HOUNKPE_HOUSEKEEPING_GENES, KEGG_TGF_BETA_SIGNALING_PATHWAY, PID_GLYPICAN_1PATHWAY, BIOCARTA_TGFB_PATHWAY, REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY, KEGG_PATHWAYS_IN_CANCER, ZAMORA_NOS2_TARGETS_UP, WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE, WP_UROTENSINIIMEDIATED_SIGNALING, WP_MESODERMAL_COMMITMENT_PATHWAY, WP_TGFB_SMAD_SIGNALING, REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS, HORIUCHI_WTAP_TARGETS_DN, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX, WP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION, WP_TGIF_DISRUPTION_OF_SHH_SIGNALING, WP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING, WP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, WP_NEOVASCULARIZATION_PROCESSES, REACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER, PUJANA_ATM_PCC_NETWORK, TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C, KEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY, PID_SMAD2_3PATHWAY, PUJANA_BRCA1_PCC_NETWORK, KEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY, PULVER_FOREY_CELLCYCLE_PEAKING_S2, DIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP, REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER, WP_INFLAMMATORY_BOWEL_DISEASE_SIGNALING, PID_TGFBR_PATHWAY, REACTOME_TRANSCRIPTIONAL_REGULATION_OF_PLURIPOTENT_STEM_CELLS, WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY, WP_HDAC6_INTERACTIONS_IN_THE_CENTRAL_NERVOUS_SYSTEM, REACTOME_FOXO_MEDIATED_TRANSCRIPTION, KEGG_COLORECTAL_CANCER, REACTOME_SIGNALING_BY_ACTIVIN, SHEN_SMARCA2_TARGETS_UP, FAELT_B_CLL_WITH_VH3_21_DN, REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS, BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP. *MSigDB: Collection C3 (Regulatory target gene sets - Gene sets representing potential targets of regulation by transcription factors or microRNAs. The sets consist of genes grouped by elements they share in their non-protein coding regions. The elements represent known or likely cis-regulatory elements in promoters and 3'-UTRs.) for SMAD2: MIR95_5P, MIR302D_5P, MIR216A_3P, MIR3913_5P, MIR522_3P, GATTGGY_NFY_Q6_01, MIR7159_5P, MIR374B_5P, MIR3671, MIR6716_5P, MYCMAX_02, MIR3184_3P, KLF7_TARGET_GENES, MIR524_5P, MIR223_5P, NFY_Q6, MIR450A_1_3P, ZSCAN30_TARGET_GENES, MIR4773, MIR624_3P, MIR224_3P, MIR498_3P, MIR409_3P, MIR3942_3P, NFY_C, POU2AF1_TARGET_GENES, MIR3714, MIR8485, MIR6868_3P, MIR3065_5P, MIR1264, MIR9500, MIR155_5P, ZNF423_TARGET_GENES, MIR340_5P, MIR548AG, MIR5584_5P, MIR4422, MIR8085, MIR30A_3P, MIR497_3P, MIR6074, MIR208A_5P, MIR4298, MIR6134, MIR365B_5P, NFY_Q6_01, AHRR_TARGET_GENES, MIR6878_5P, MIR4761_5P, AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D, MIR5590_3P, MIR103A_1_5P, MIR4305, MIR365A_5P, MIR1302, ZNF592_TARGET_GENES, MAX_01, MIR374A_5P, MIR769_5P, MIR4496, MIR30E_3P, ZNF282_TARGET_GENES, CAGCACT_MIR5123P, TOP2B_TARGET_GENES, MIR5002_5P, MIR656_3P, MIR302A_5P, MYCMAX_01, MIR520E_5P, MIR374B_3P, MIR551B_5P, HMX1_01, MIR30D_3P, MIR12124, NFY_01, MIR4799_5P, GGTGTGT_MIR329, MIR607, GGGTGGRR_PAX4_03, MIR4724_3P, ZNF407_TARGET_GENES, MIR520D_5P, MIR548AI_MIR570_5P, AACTTT_UNKNOWN, MIR302B_5P, MIR4735_3P, CCAATNNSNNNGCG_UNKNOWN, MIR18A_5P_MIR18B_5P, MIR103A_2_5P, MIR548BA, MIR1910_3P, MIR34C_3P, MIR3121_3P, MIR142_5P, MIR3122, MIR128_3P, GCTNWTTGK_UNKNOWN, CEBPZ_TARGET_GENES, SMARCA1_TARGET_GENES, GCACCTT_MIR18A_MIR18B, MIR3913_3P, MIR190B_3P, ALPHACP1_01, MIR4719, MIR3692_5P, MIR1237_3P, MIR5692B_MIR5692C, MIR5004_5P, MIR767_3P, ZNF549_TARGET_GENES, CACGTG_MYC_Q2, MIR6511A_5P, MIR12136, MIR3919, MIR3679_3P, MIR93_3P, MIR4272, MIR6731_5P, MIR208B_5P, MIR6792_5P. *MSigDB: Collection C4 (Computational gene sets - Computational gene sets defined by mining large collections of cancer-oriented expression data.) for SMAD2: GCM_UBE2N, MORF_PPP2R5E, MORF_BECN1, MORF_PRKAG1, MORF_RAB1A, MORF_UBE2A, MORF_TERF2IP, MORF_DDB1, MORF_SS18, MORF_TPR, GCM_MAX, GCM_DFFA, GCM_ZNF198, MORF_RAB11A. *MSigDB: Collection C6 (Oncogenic signature gene sets - Gene sets that represent signatures of cellular pathways which are often dis-regulated in cancer. The majority of signatures were generated directly from microarray data from NCBI GEO or from internal unpublished profiling experiments involving perturbation of known cancer genes.) for SMAD2: SNF5_DN.V1_UP. *MSigDB: Collection C7 (Immunologic signature gene sets - Gene sets that represent cell states and perturbations within the immune system.) for SMAD2: GSE15624_CTRL_VS_3H_HALOFUGINONE_TREATED_CD4_TCELL_UP, GSE22025_PROGESTERONE_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN, GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN, GSE15930_STIM_VS_STIM_AND_IFNAB_72H_CD8_T_CELL_DN, GSE8515_CTRL_VS_IL6_4H_STIM_MAC_UP, GSE36009_UNSTIM_VS_LPS_STIM_DC_DN, GSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN, GSE339_CD4POS_VS_CD8POS_DC_DN, GSE26030_TH1_VS_TH17_RESTIMULATED_DAY15_POST_POLARIZATION_DN, GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_3H_UP, GSE8868_SPLEEN_VS_INTESTINE_CD11B_POS_CD11C_NEG_DC_UP, GSE12198_LOW_IL2_STIM_NK_CELL_VS_HIGH_IL2_STIM_NK_CELL_UP, GSE14769_UNSTIM_VS_40MIN_LPS_BMDM_DN, GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN, NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_UP, GSE40274_CTRL_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP, GSE27786_LIN_NEG_VS_CD4_TCELL_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_DN, GSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN, GSE7831_UNSTIM_VS_INFLUENZA_STIM_PDC_1H_DN, GSE17721_LPS_VS_CPG_6H_BMDC_UP, NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP, GSE22886_IL2_VS_IL15_STIM_NKCELL_DN, GSE6566_STRONG_VS_WEAK_DC_STIMULATED_CD4_TCELL_DN, GSE17721_12H_VS_24H_POLYIC_BMDC_UP, GSE5589_WT_VS_IL6_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN, GSE11864_UNTREATED_VS_CSF1_IN_MAC_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_PRO_BCELL_DN, GSE1460_INTRATHYMIC_T_PROGENITOR_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP, GSE17721_CTRL_VS_GARDIQUIMOD_4H_BMDC_DN, GSE18281_MEDULLARY_THYMOCYTE_VS_WHOLE_MEDULLA_THYMUS_DN, GSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP, GSE29949_CD8_POS_DC_SPLEEN_VS_DC_BRAIN_UP, GSE6090_UNSTIM_VS_DC_SIGN_STIM_DC_UP, GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_UP, GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_24H_CD8_T_CELL_DN, GSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GSE37416_12H_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_DN, GSE17721_LPS_VS_GARDIQUIMOD_24H_BMDC_DN, GSE29618_PRE_VS_DAY7_FLU_VACCINE_PDC_DN, GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_DN, GSE17721_12H_VS_24H_CPG_BMDC_UP, GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_180MIN_DN, GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_DN, GSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_UP, GSE11818_WT_VS_DICER_KO_TREG_DN, GSE14908_RESTING_VS_HDM_STIM_CD4_TCELL_NONATOPIC_PATIENT_UP, GSE2770_TGFB_AND_IL4_VS_IL4_TREATED_ACT_CD4_TCELL_6H_UP, GSE4984_GALECTIN1_VS_VEHICLE_CTRL_TREATED_DC_UP, GSE2770_TGFB_AND_IL4_ACT_VS_ACT_CD4_TCELL_6H_UP, GSE17721_POLYIC_VS_CPG_4H_BMDC_DN, GSE22886_TH1_VS_TH2_48H_ACT_DN, GSE15930_STIM_VS_STIM_AND_TRICHOSTATINA_72H_CD8_T_CELL_DN, GSE339_EX_VIVO_VS_IN_CULTURE_CD8POS_DC_UP, GSE27786_NKTCELL_VS_MONO_MAC_DN, GSE411_WT_VS_SOCS3_KO_MACROPHAGE_DN, GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_180MIN_DN, GSE40274_FOXP3_VS_FOXP3_AND_SATB1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN, GSE36078_WT_VS_IL1R_KO_LUNG_DC_UP, GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN, GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_AT_DX_UP, GSE17721_LPS_VS_CPG_24H_BMDC_DN, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_12H_ACT_CD4_TCELL_UP. *MSigDB: Collection C8 (C8 cell type signature gene sets - Gene sets that contain curated cluster markers for cell types identified in single-cell sequencing studies of human tissue.) for SMAD2: .\\n• *UniProt: Information collected from UniProt: Isoform localizations: General locations: Cytoplasm, Nucleus — Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) — TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta Associated diseases: Congenital heart defects, multiple types, 8, with or without heterotaxy, Loeys-Dietz syndrome 6.\\n• *OpenTargets: Direct disease associations for SMAD2: Overgrowth, Abnormality of the cardiovascular system, Mitral valve prolapse, Congestive heart failure, Patent ductus arteriosus, Dilated cardiomyopathy, Bicuspid aortic valve, Myocardial fibrosis, Increased total eosinophil count, Thrombocytosis, Anemia, Acute kidney injury, Glucose intolerance, Pulmonary hypoplasia, Pneumonia, Asthma, Ischemic stroke, Cerebral ischemia, Vascular dilatation, Aortic dissection, Systemic lupus erythematosus, Autoimmunity, Hyperglycemia, Hyperlipidemia, Hypercholesterolemia, Skeletal muscle atrophy, Muscular dystrophy, Cachexia, Thrombophlebitis, Miscarriage, Ureteral obstruction, Airway obstruction, Amyotrophic lateral sclerosis, Peripheral demyelination, Inflammatory abnormality of the skin, Arrhythmia, Myelofibrosis, Hepatitis, Reduced sperm motility, Urethral stricture, Renal atrophy, Cervical polyp, Shock, Granuloma, Chronic colitis, Neoplasm of the lung, Cognitive impairment, Sepsis, geleophysic dysplasia, colorectal adenoma, airway hyperresponsiveness, skin aging, triple-negative breast cancer, bile duct carcinoma, glioma, hydronephrosis, rectal adenocarcinoma, intracerebral hemorrhage, renal cell adenocarcinoma, Autoimmune Hepatitis, neurodegenerative disease, brain disease, aortic disease, allergic rhinitis, esophageal squamous cell carcinoma, head and neck neoplasia, breast ductal adenocarcinoma, laryngeal squamous cell carcinoma, ovarian adenocarcinoma, ovarian mucinous adenocarcinoma, ovarian teratoma, bladder transitional cell carcinoma, brain glioblastoma, dysplastic oral keratinocyte, undifferentiated carcinoma, cerebral amyloid angiopathy, head and neck malignant neoplasia, breastfeeding duration, urgency urinary incontinence, fibrosis, Balkan nephropathy, congenital rubella, echinococcosis, Gerstmann syndrome, inclusion body myositis, muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10, severe neurodegenerative syndrome with lipodystrophy, Diamond-Blackfan anemia, cardiofaciocutaneous syndrome, adrenomyeloneuropathy, hereditary sensory and autonomic neuropathy, nasopharyngeal carcinoma, keratoconus, dentin dysplasia, T-cell non-Hodgkin lymphoma, dyskeratosis congenita, pneumoconiosis, early myoclonic encephalopathy, laryngotracheoesophageal cleft, cleft palate, cryopyrin-associated periodic syndrome, holoprosencephaly, pachyonychia congenita, familial rhabdoid tumor, familial hyperaldosteronism, primary ciliary dyskinesia, meningioma, pilocytic astrocytoma, hemangioblastoma, microcephaly-brain defect-spasticity-hypernatremia syndrome, thanatophoric dysplasia, idiopathic pulmonary arterial hypertension, heritable pulmonary arterial hypertension, juvenile polyposis syndrome, congenital herpes simplex virus infection, popliteal pterygium syndrome, ameloblastoma, hypersensitivity pneumonitis, persistent truncus arteriosus, colorectal adenocarcinoma, Crohn's disease, cutaneous melanoma, diabetes mellitus, diabetic nephropathy, diffuse gastric adenocarcinoma, diffuse large B-cell lymphoma, breast ductal carcinoma in situ, emphysema, epilepsy, esophageal adenocarcinoma, fetal growth restriction, follicular thyroid adenoma, ganglioneuroma, follicular thyroid carcinoma, gastric adenocarcinoma, gastric intestinal type adenocarcinoma, genetic disorder, germ cell tumor, glioblastoma multiforme, hypertrophic cardiomyopathy, immune system disease, infection, infertility, injury, insulinoma, intracranial hemorrhage, ischemia, large cell neuroendocrine carcinoma, leukemia, lung adenocarcinoma, lymphoma, mesothelioma, metabolic disease, myocardial infarction, neoplasm, nervous system disease, neuroblastoma, oligodendroglioma, osteosarcoma, neural tube defect, tuberculosis, glioblastoma, carcinoma of liver and intrahepatic biliary tract, hereditary nonpolyposis colon cancer, Zika virus infectious disease, left ventricular noncompaction, multiminicore myopathy, Loeys-Dietz syndrome, neurofibromatosis type 1, Leber congenital amaurosis, osteogenesis imperfecta, progressive supranuclear palsy, intrahepatic cholestasis, lymphedema, posterior cortical atrophy, follicular lymphoma, kidney Wilms tumor, bronchopulmonary dysplasia, sarcoidosis, peeling skin syndrome, lissencephaly with cerebellar hypoplasia, aggressive NK-cell leukemia, adult T-cell leukemia/lymphoma, extranodal nasal NK/T cell lymphoma, Turner syndrome, familial thoracic aortic aneurysm and aortic dissection, Ehlers-Danlos syndrome, muscular dystrophy, precursor B-cell acute lymphoblastic leukemia, superficial spreading melanoma, lung neoplasm, intestinal neoplasm, odontogenic neoplasm, disorder of ear, endometrium neoplasm, prostate neoplasm, mucoepidermoid carcinoma of parotid gland, carcinoma of pharynx, polyp of colon, low grade glioma, corticobasal degeneration disorder, cervical intraepithelial neoplasia, viral myocarditis, lip and oral cavity carcinoma, corneal infection, pseudoxanthoma elasticum (inherited or acquired), chondrogenic neoplasm, intraepithelial neoplasia, squamous cell intraepithelial neoplasia, liver and intrahepatic bile duct neoplasm, hypertensive nephropathy, myocardial disorder, tubular adenoma, pulmonary sarcoidosis, gonorrhea, B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, gastric carcinoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, Hodgkins lymphoma, invasive breast ductal carcinoma, metabolic syndrome, myelodysplastic syndrome, oral squamous cell carcinoma, gastritis, acute lymphoblastic leukemia, acute myeloid leukemia, acute promyelocytic leukemia, adenocarcinoma, adenoma, age, aortic stenosis, astrocytoma, atopic eczema, atrial fibrillation, Barrett's esophagus, benign prostatic hyperplasia, bladder tumor, breast adenocarcinoma, breast carcinoma, bronchoalveolar adenocarcinoma, carcinoma, cardiomyopathy, cardiovascular disease, central nervous system cancer, chondrosarcoma, chromophobe renal cell carcinoma, chronic myelogenous leukemia, chronic obstructive pulmonary disease, clear cell renal carcinoma, endometrial carcinoma, ovarian serous carcinoma, renal fibrosis, Abruptio Placentae, Adenomyosis, Carcinoma, Lewis Lung, chronic myelomonocytic leukemia, Marchiafava-Bignami Disease, oral submucous fibrosis, osteoradionecrosis, renal nutcracker syndrome, amyloidosis, mucositis, neuroendocrine neoplasm, neuromuscular disease, oral mucositis, Spinal cord injury, cutaneous squamous cell carcinoma, Barrett adenocarcinoma, colon adenocarcinoma, colon carcinoma, colorectal carcinoma, pharyngeal squamous cell carcinoma, soft tissue sarcoma, undifferentiated pleomorphic sarcoma, connective tissue disease, pneumonitis, intrahepatic cholangiocarcinoma, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps, glomerular disease, nephritis, Neurogenic bladder, Glomerular sclerosis, Glomerulonephritis, Nephropathy, Uterine leiomyoma, Cleft palate, Hydrocephalus, Cataract, Myopia, Autism, Infertility, Diabetes mellitus, Insulin resistance, Osteoporosis, Hyperkeratosis, Intellectual disability, Ataxia, Mental deterioration, Stroke, Rheumatoid arthritis, Cirrhosis, Hepatic fibrosis, Hepatic steatosis, Obesity, mixed connective tissue disease, pneumocystosis, pseudomyxoma peritonei, silicosis, toxoplasmosis, hemoglobin A1 measurement, BMI-adjusted waist-hip ratio, liver dysplastic nodule, gut microbiome measurement, platelet crit, allergen exposure measurement, calf circumference measurement, dysplasia, lobular breast carcinoma, nodular melanoma, non-functioning pituitary adenoma, status epilepticus, steatosis, urothelial carcinoma, digestive system neoplasm, Hepatobiliary Neoplasm, American trypanosomiasis, acute myocardial infarction, pemphigus foliaceus, cystic kidney disease, Polycystic Kidney Disease, arteriosclerosis, hyperuricemia, skin carcinoma, heel bone mineral density, pulmonary fibrosis, hyperaldosteronism, gastric ulcer, infarction, aortic valve disease, heart valve disease, mitral valve disease, urinary tract obstruction, prostate disease, stomach disease, myocarditis, aneurysm, enthesopathy, musculoskeletal system disease, metastasis, Gallbladder Adenocarcinoma, Granular Cell Tumor, Hepatoblastoma, HER2 Positive Breast Carcinoma, Invasive Breast Carcinoma, Malignant Mesothelioma, Malignant Pancreatic Neoplasm, Medullomyoblastoma with Myogenic Differentiation, Microcystic Meningioma, Mixed Tumor of the Salivary Gland, Nasal Cavity Polyp, Osteoblastoma, Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation, Ovarian Endometriosis, Paraganglioma, Placental Choriocarcinoma, Rectal Tubular Adenoma, Sarcomatoid Carcinoma, Signet Ring Cell Gastric Adenocarcinoma, Synovial Chondromatosis, Testicular Non-Seminomatous Germ Cell Tumor, Testicular Yolk Sac Tumor, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Uterine Carcinosarcoma, Vulvar Squamous Cell Carcinoma, acute respiratory distress syndrome, sarcopenia, rectum cancer, acanthosis nigricans, mucous membrane pemphigoid, punctate palmoplantar keratoderma type III, adrenal cortex carcinoma, alcoholic liver cirrhosis, atrophic gastritis, dental fluorosis, dry eye syndrome, Helicobacter pylori infectious disease, inflammatory breast carcinoma, multiple system atrophy, myeloid sarcoma, nodular goiter, periapical granuloma, pulmonary edema, renovascular hypertension, retinopathy of prematurity, rheumatic heart disease, thromboangiitis obliterans, tooth disease, uremia, non-alcoholic steatohepatitis, Cryptogenic Organizing Pneumonia, Fascioliasis, Follicular Cyst, Heavy Chain Disease, Hepatopulmonary Syndrome, Myocardial Ischemia, Pelvic Inflammatory Disease, Periapical Periodontitis, Peritoneal Fibrosis, Pneumonia, Aspiration, Respiratory Syncytial Virus Infection, diabetic cardiomyopathy, diabetic foot, endothelial dysfunction, Mantle cell lymphoma, Merkel cell skin cancer, schistosomiasis, abortion, Autosomal dominant polycystic kidney disease, osteoporosis-pseudoglioma syndrome, Bartsocas-Papas syndrome 1, congenital bilateral aplasia of vas deferens from CFTR mutation, SHOX-related short stature, intellectual disability, X-linked syndromic, Turner type, Fabry disease, X-linked corneal dermoid, Aarskog-Scott syndrome, X-linked, holoprosencephaly-hypokinesia-congenital contractures syndrome, Melnick-Needles syndrome, Duchenne muscular dystrophy, X-linked retinoschisis, Wilson disease, adenomyosis, Timothy syndrome, supranuclear palsy, progressive, 1, Ehlers-Danlos syndrome, musculocontractural type, tetrasomy 12p, sickle cell anemia, hypotonia-cystinuria syndrome, lymphangioleiomyomatosis, gastrointestinal stromal tumor, autoimmune lymphoproliferative syndrome type 2B, endometrial cancer, Loeys-Dietz syndrome 1, hyperinsulinemic hypoglycemia, familial, 4, preterm premature rupture of the membranes, Mungan syndrome, Crouzon syndrome-acanthosis nigricans syndrome, papillary renal cell carcinoma, papillary thyroid carcinoma, periodontitis, polycystic ovary syndrome, preeclampsia, prostate adenocarcinoma, psoriasis, pterygium, renal cell carcinoma, rheumatoid arthritis, sarcoma, severe acute respiratory syndrome, small cell lung carcinoma, squamous cell carcinoma, squamous cell lung carcinoma, spondyloarthropathy, stroke, subarachnoid hemorrhage, systemic scleroderma, ulcerative colitis, melanoma, hepatocellular adenoma, viral disease, HIV infection, idiopathic pulmonary fibrosis, malignant pleural mesothelioma, bacterial disease, pneumococcal infection, temporal lobe epilepsy, celiac disease, cervical carcinoma, cytomegalovirus infection, endometriosis, experimental autoimmune encephalomyelitis, parasitic infection, malaria, folate deficiency, lung carcinoma, ovarian carcinoma, familial amyotrophic lateral sclerosis, pulmonary arterial hypertension, age-related macular degeneration, synovial sarcoma, cerebral creatine deficiency syndrome, arterial disorder, glomerulosclerosis, villous adenoma, mucosal melanoma, ovarian clear cell cancer, central nervous system primitive neuroectodermal neoplasm, Crohn ileitis, vertebral column disorder, endometrial disorder, gastric cancer, penile cancer, myopia, pulmonary alveolar proteinosis, Chagas disease, leiomyoma, brain cancer, tuberous sclerosis, sick sinus syndrome, arteriovenous hemangioma/malformation, hypertensive heart disease, head and neck carcinoma, depressive disorder, pneumothorax, Richter syndrome, peritoneum cancer, thyroid cancer, disorder of sexual differentiation, vulvar melanoma, papilloma, rectosigmoid junction neoplasm, Treacher-Collins syndrome, prostatic acinar adenocarcinoma, gingival overgrowth, inherited lipid metabolism disorder, skin squamous cell carcinoma, teratoma, bone inflammation disease, extraosseous osteosarcoma, chondroblastic osteosarcoma, cerebral infarction, liver cancer, uterine cancer, lung benign neoplasm, skin cancer, cervical cancer, seminoma, breast angiosarcoma, cerebellar pilocytic astrocytoma, salivary gland adenoid cystic carcinoma, bile duct adenocarcinoma, gastroesophageal junction adenocarcinoma, thoracic cancer, acral lentiginous melanoma, endometrial mixed adenocarcinoma, female breast carcinoma, inflammation, erythrocyte volume, glomerular filtration rate, bone tissue density, progesterone amount, serum alanine aminotransferase amount, serum urea amount, serum creatinine amount, body height, cyst, Hypotonia - cystinuria syndrome, Chédiak-Higashi syndrome, Åland Islands eye disease, Hydrocephalus with stenosis of the aqueduct of Sylvius, Autoimmune lymphoproliferative syndrome with recurrent viral infections, Rare disease with thoracic aortic aneurysm and aortic dissection, Persistent Müllerian duct syndrome, WHIM syndrome, Familial adenomatous polyposis, Other metabolic disease, hematocrit, C-reactive protein measurement, hematological measurement, alkaline phosphatase measurement, cryptorchidism, lymphocyte count, gestational diabetes, acute lung injury, serum gamma-glutamyl transferase measurement, HbA1c measurement, high density lipoprotein cholesterol measurement, osteoarthritis, knee, wet macular degeneration, insomnia, hypothyroidism, pelvic organ prolapse, metabolite measurement, eosinophil count, lymph node metastatic carcinoma, embryonal carcinoma, lumbar disc degeneration, lean body mass, type 2 diabetes nephropathy, monocyte count, autoimmune disease, congenital heart disease, cholangiocarcinoma, human african trypanosomiasis, reading, congenital heart malformation, temporomandibular joint disorder, axial length measurement, myeloid leukemia, lupus erythematosus, allergic asthma, fatty liver disease, Alzheimer disease, asthma, urinary bladder carcinoma, cancer, glaucoma, schizophrenia, cataract, type 1 diabetes mellitus, type 2 diabetes mellitus, pulmonary hypertension, osteoarthritis, pancreatic ductal adenocarcinoma, bacterial urinary tract infection, multiple sclerosis, skin basal cell carcinoma, brain glioma, colorectal cancer, Wilms tumor, Townes-Brocks syndrome, nevoid basal cell carcinoma syndrome, breast cancer, congenital contractural arachnodactyly, Duane retraction syndrome, dyschromatosis symmetrica hereditaria, metastatic malignant neoplasm, Loeys-Dietz syndrome 6, cervical squamous intraepithelial neoplasia, leukoplakia, spinal cord injury, ulcer disease, desmoplastic melanoma, myelofibrosis, oral cavity carcinoma, rectal carcinoma, hydrocephalus, congenital, 3, with brain anomalies, nasal cavity and paranasal sinus carcinoma, COVID-19, Dravet syndrome, COVID-19–associated multisystem inflammatory syndrome in adults, disease arising from reactivation of latent virus, Friedreich ataxia, malignant glioma, achalasia-alacrima syndrome, metabolic bone disorder, congenital heart defects, multiple types, 8, with or without heterotaxy, postmenopausal osteoporosis, intestinal polyp, dissection, uterine neoplasm, pancreatic neoplasm, kidney neoplasm, breast neoplasm, brain aneurysm, colitis, osteoporosis, chronic kidney disease, ovarian neoplasm, acne, stomach neoplasm, ankylosing spondylitis, ciliopathy, deep vein thrombosis, obstructive sleep apnea, necrotizing enterocolitis, relapsing-remitting multiple sclerosis, angiosarcoma, colorectal neoplasm, atherosclerosis, open-angle glaucoma, androgenetic alopecia, basal cell carcinoma, IGA glomerulonephritis, hepatitis B virus infection, skin neoplasm, Keloid, Abdominal Aortic Aneurysm, chronic hepatitis C virus infection, eosinophilic esophagitis, focal segmental glomerulosclerosis, interstitial lung disease, mucocutaneous lymph node syndrome, myeloproliferative disorder, nephrotic syndrome, vascular disease, thoracic aortic aneurysm, venous thromboembolism, platelet count, body mass index, neuroimaging measurement, metastatic neoplasm, whole body water mass, kidney injury, bone metastasis, gastrointestinal disease, aspartate aminotransferase to alanine aminotransferase ratio, urea measurement, viral load, 2-hydroxyacetaminophen sulfate measurement, aging, serum lipopolysaccharide activity, cecum adenocarcinoma, chronic rhinosinusitis, cystitis, ependymoma, granulosa cell tumor, metaplastic breast carcinoma, ovarian clear cell adenocarcinoma, pancreatic adenocarcinoma, pancreatic neuroendocrine tumor, ACTH-Producing Pituitary Gland Adenoma, Adenomatoid Odontogenic Tumor, Ampulla of Vater Carcinoma, Anal Squamous Cell Carcinoma, Anaplastic (Malignant) Meningioma, Appendix Adenocarcinoma, Appendix Goblet Cell Carcinoid, Atrophy, Atypical Meningioma, Bladder Small Cell Neuroendocrine Carcinoma, Breast Carcinoma by Gene Expression Profile, cervical squamous cell carcinoma, Columnar Cell Hyperplasia of the Breast, Duodenal Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Extramammary Paget Disease, fibrodysplasia ossificans progressiva, hereditary diffuse gastric adenocarcinoma, Holt-Oram syndrome, Huntington disease, Pallister-Hall syndrome, Nager acrofacial dysostosis, Marfan syndrome, Cowden syndrome 1, nail-patella syndrome, ovarian cancer, Andersen-Tawil syndrome, polyostotic fibrous dysplasia, juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome, nonpapillary renal cell carcinoma, Mobius syndrome, Peyronie disease, prostate cancer, retinoblastoma, acrodermatitis enteropathica, mitochondrial DNA depletion syndrome 4a, Alstrom syndrome, anencephaly 1, microphthalmia with limb anomalies, Bloom syndrome, lung cancer, cerebrotendinous xanthomatosis, cystic fibrosis, recessive dystrophic epidermolysis bullosa, Haim-Munk syndrome, Laurence-Moon syndrome, Nijmegen breakage syndrome, Miyoshi myopathy, Schwartz-Jampel syndrome, Leigh syndrome, multiple myeloma, cervical adenocarcinoma, liver disease, cirrhosis of liver, ischemic cardiomyopathy, lymphoid neoplasm, coronary artery disease, prostate carcinoma, aortic aneurysm, fibrosarcoma, hypertrophy, actinic keratosis, anaplastic astrocytoma, anaplastic oligodendroglioma, cardiac hypertrophy, AIDS dementia, pancreatic carcinoma, prostate intraepithelial neoplasia, thyroid carcinoma, insulin resistance, esophageal carcinoma, ovarian serous adenocarcinoma, rhabdomyosarcoma, medulloblastoma, acute megakaryoblastic leukaemia, hepatitis C virus infection, non-small cell lung carcinoma, pleomorphic liposarcoma, kidney disease, non-alcoholic fatty liver disease, Pick disease, testicular seminoma, osteomyelitis, spina bifida, heart failure, vitamin D deficiency, inflammatory bowel disease, diabetic retinopathy, heart disease, psoriatic arthritis, lung disease, dental caries, serous adenocarcinoma, retinopathy, adrenal gland neoplasm. *OpenTargets: Tissue-specific expression binned z-scores for SMAD2 (>=2 indicates 75th percentile and is tissue-specific; z-scores per gene per tissue, binned into 10 quantile-based bins): {'frontal lobe': -1, 'endothelial cell of umbilical vein (resting)': 2, 'zone of skin': 0, 'regulatory T cell': 1, 'pancreas': -1, 'suprapubic skin': -1, 'temporal lobe': -1, 'parathyroid gland': -1, 'spleen': -1, 'Brodmann (1909) area 9': -1, 'breast': -1, 'Brodmann (1909) area 24': -1, 'alternatively activated macrophage': 2, 'segmented neutrophil of bone marrow': 4, 'placenta': -1, 'mature eosinophil': 1, 'granulocyte monocyte progenitor cell': 0, 'gall bladder': -1, 'esophagus muscularis mucosa': -1, 'seminal vesicle': -1, 'endocervix': -1, 'lower leg skin': -1, 'megakaryocyte-erythroid progenitor cell': 0, 'endothelial cell of umbilical vein (proliferating)': 2, 'CD8-positive, alpha-beta T cell': 3, 'cerebral cortex': -1, 'CD34-negative, CD41-positive, CD42-positive megakaryocyte cell': 4, 'hippocampus proper': -1, 'uterus': -1, 'CD4-positive, alpha-beta T cell': 3, 'tonsil': -1, 'esophagus': 0, 'transverse colon': -1, 'pituitary gland': -1, 'coronary artery': -1, 'memory B cell': 0, 'sigmoid colon': -1, 'cerebellum': -1, 'erythroblast': 2, 'prefrontal cortex': -1, 'nucleus accumbens': -1, 'adipose tissue': 0, 'effector memory CD8-positive, alpha-beta T cell': 1, 'vermiform appendix': -1, 'greater omentum': -1, 'hematopoietic multipotent progenitor cell': 1, 'leukocyte': 2, 'adrenal gland': -1, 'atrium auricular region': -1, 'thyroid gland': 0, 'tibial artery': -1, 'common lymphoid progenitor': 3, 'urinary bladder': -1, 'duodenum': -1, 'heart muscle': -1, 'small intestine': -1, 'neutrophilic metamyelocyte': 3, 'minor salivary gland': -1, 'rectum': 0, 'ovary': -1, 'substantia nigra': -1, 'subcutaneous adipose tissue': -1, 'class switched memory B cell': 1, 'fallopian tube': -1, 'esophagus mucosa': -1, 'CD38-negative naive B cell': 0, 'bronchus': -1, 'EBV-transformed lymphocyte': 0, \\\"small intestine Peyer's patch\\\": -1, 'kidney': -1, 'hippocampus': -1, 'macrophage': 1, 'aorta': -1, 'skeletal muscle tissue': -1, 'CD3-positive, CD4-positive, CD8-positive, double positive thymocyte': 4, 'caudate-putamen': -1, 'liver': -1, 'cytotoxic CD56-dim natural killer cell': 2, 'mature neutrophil': 2, 'hypothalamus': -1, 'transformed skin fibroblast': -1, 'bone marrow': -1, 'inflammatory macrophage': 0, 'cortex of kidney': -1, 'lung': -1, 'epididymis': -1, 'abdomen': -1, 'saliva-secreting gland': -1, 'nasopharynx': -1, 'colon': 0, 'cerebellar hemisphere': -1, 'stomach': -1, 'testis': -1, 'smooth muscle tissue': 0, 'putamen': -1, 'CD4-positive, alpha-beta thymocyte': 5, 'C1 segment of cervical spinal cord': 0, 'blood': -1, 'hematopoietic stem cell': 1, 'caudate nucleus': -1, 'amygdala': -1, 'brain': 0, 'central memory CD8-positive, alpha-beta T cell': 1, 'effector memory CD4-positive, alpha-beta T cell': 1, 'ectocervix': -1, 'prostate gland': -1, 'conventional dendritic cell': 4, 'central memory CD4-positive, alpha-beta T cell': 1, 'heart left ventricle': -1, 'CD14-positive, CD16-negative classical monocyte': 0, 'vagina': -1, 'esophagogastric junction': -1, 'lymph node': -1, 'endometrium': -1, 'heart': -1, 'oral mucosa': -1, 'CD8-positive, alpha-beta thymocyte': 4, 'common myeloid progenitor': 0, 'tibial nerve': -1, 'plasma cell': -1}. *OpenTargets: SMAD2 is not a core essential gene (inhibition/knockout not consistently lethal across most cell lines; not universally vital for survival). *OpenTargets: Genetic constraint score for syn variants (Synonymous (silent) variants - don't change amino acid sequence of a protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 0.11195000261068344 *OpenTargets: Genetic constraint score for mis variants (Missense variants - lead to amino acid substitution in the protein) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 4.47730016708374 *OpenTargets: Genetic constraint score for lof variants (Loss-of-function variants - include nonsense, frameshift, and canonical splice site variants) in SMAD2; scores -1 to 1 map to LOEUF rank (lower = less tolerant): 1.0\\n• *HumanBase: Predicted disease associations for SMAD2 (score>0.7): aortic disease: An artery disease that is characterized by degeneration of the cells composing the aortic wall. (score=0.709).\\n• *GO: SMAD2 representative GO terms: C:cytoplasm, C:nucleus, C:chromatin, C:heteromeric SMAD protein complex, C:cytosol, C:nucleoplasm, F:DNA-binding transcription factor activity, F:disordered domain specific binding, F:identical protein binding, F:transforming growth factor beta receptor binding, F:cis-regulatory region sequence-specific DNA binding, F:metal ion binding, P:primary miRNA processing, P:lung development, P:endoderm formation, P:odontoblast differentiation, P:determination of left/right asymmetry in lateral mesoderm, P:gastrulation.\"],[\"20251224-191245_ui/genes/SMAD2/transcripts.tsv\",\"transcript_id\\tn_exons\\tname\\tstatus\\taliases\\tlocations\\tnotes\\tsource\\r\\ngeneral_localization\\t\\tgeneral_localization\\t\\t\\tCytoplasm,Nucleus\\tCytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) | TISSUE SPECIFICITY: Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta\\tisoforms\\r\\n\"]]"))) LOCAL_FILES.set(k, v); }catch(e){ console.warn('LOCAL_FILES restore failed:', e); } try{ FILE_CACHE.clear(); for (const [k, v] of JSON.parse(JSON.parse("[]"))) FILE_CACHE.set(k, v); }catch(e){ console.warn('FILE_CACHE restore failed:', e); } // Keep window aliases for debugging window.STATE = STATE; window.LOCAL_FILES = LOCAL_FILES; window.FILE_CACHE = FILE_CACHE; if(true) document.body.classList.add('light'); else document.body.classList.remove('light'); // Ensure we start with grid visible (not hero) HERO_SHOWN = false; // Wait for DOMContentLoaded if refresh is defined, otherwise use polling if (document.readyState === 'loading') { document.addEventListener('DOMContentLoaded', function() { // Show grid, hide hero (in case CSS didn't handle it) var hero = document.getElementById('hero'); var grid = document.getElementById('grid'); var toolbar = document.getElementById('toolbar'); if (hero) hero.style.display = 'none'; if (grid) grid.style.display = 'block'; if (toolbar) toolbar.style.display = 'flex'; if (typeof refresh === 'function') refresh(); }); } else { // Document already loaded var hero = document.getElementById('hero'); var grid = document.getElementById('grid'); var toolbar = document.getElementById('toolbar'); if (hero) hero.style.display = 'none'; if (grid) grid.style.display = 'block'; if (toolbar) toolbar.style.display = 'flex'; // Check if refresh exists let attempts = 0; const tryRefresh = setInterval(function() { attempts++; if (typeof refresh === 'function') { refresh(); clearInterval(tryRefresh); } else if (attempts > 20) { console.warn('refresh() function not found after 20 attempts'); clearInterval(tryRefresh); } }, 100); } }catch(e){ console.error('Snapshot boot failed:', e); alert('Failed to restore saved state. 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